Research and Technology 1997

NASA Technical Reports Server (NTRS)

1998-01-01

This report highlights the challenging work accomplished during fiscal year 1997 by Ames research scientists and engineers. The work is divided into accomplishments that support the goals of NASA s four Strategic Enterprises: Aeronautics and Space Transportation Technology, Space Science, Human Exploration and Development of Space (HEDS), and Earth Science. NASA Ames Research Center s research effort in the Space, Earth, and HEDS Enterprises is focused i n large part to support Ames lead role for Astrobiology, which broadly defined is the scientific study of the origin, distribution, and future of life in the universe. This NASA initiative in Astrobiology is a broad science effort embracing basic research, technology development, and flight missions. Ames contributions to the Space Science Enterprise are focused in the areas of exobiology, planetary systems, astrophysics, and space technology. Ames supports the Earth Science Enterprise by conducting research and by developing technology with the objective of expanding our knowledge of the Earth s atmosphere and ecosystems. Finallv, Ames supports the HEDS Enterprise by conducting research, managing spaceflight projects, and developing technologies. A key objective is to understand the phenomena surrounding the effects of gravity on living things. Ames has also heen designated the Agency s Center of Evcellence for Information Technnlogv. The three cornerstones of Information Technology research at Ames are automated reasoning, human-centered computing, and high performance computing and networking.

ACD16-0001-018

NASA Image and Video Library

2016-01-06

This Nissan LEAF vehicle being tested on the Ames campus is equipped with cameras, sensors and cellular data networking, and uses robotics software originally developed for Ames’ K-10 and K-REX planetary rovers to operate autonomously. Shown here are Kathy Sun and Liam Pedersen, Nissan who are awaiting the arrival of the visiting group from Renault-Nissan Alliance for a demo ride across Ames.

AmeriFlux US-Br1 Brooks Field Site 10- Ames

DOE Data Explorer

Parkin, Tim [USDA; Prueger, John [National Laboratory for Agriculture and the Environment

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Br1 Brooks Field Site 10- Ames. Site Description - The Brooks Field Site 10 - Ames Site is one of three sites (Brooks Field Site 11 and Brooks Field Site 1011) located in a corn/soybean agricultural landscape of central Iowa. The farming systems, associated tillage, and nutrient management practices for soybean/corn production are typical of those throughout Upper Midwest Corn Belt. All three sites are members of the AmeriFlux network. Information for all three can be found in synchronous pages of this website.

AmeriFlux US-Br3 Brooks Field Site 11- Ames

DOE Data Explorer

Parkin, Tim [USDA; Prueger, John [National Laboratory for Agriculture and the Environment

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Br3 Brooks Field Site 11- Ames. Site Description - The Brooks Field Site 11 - Ames Site is one of three sites (Brooks Field Site 10 and Brooks Field Site 1011) located in a corn/soybean agricultural landscape of central Iowa. The farming systems, associated tillage, and nutrient management practices for soybean/corn production are typical of those throughout Upper Midwest Corn Belt. All three sites are members of the AmeriFlux network. Information for all three can be found in synchronous pages of this website.

Simulation of Ames Backbone Network

NASA Technical Reports Server (NTRS)

Shahnasser, Hamid

1998-01-01

The networking demands of Ames Research Center are dramatically increasing. More and more workstations are requested to run video and audio applications on the network. These applications require a much greater bandwidth than data applications. The existing ARCLAN 2000 network bandwidth is insufficient, due to the use of FDDI as its backbone, for accommodating video applications. Operating at a maximum of 100 Mbps, FDDI can handle only a few workstations running multimedia applications. The ideal solution is to replace the current ARCLAN 2000 FDDI backbone with an ATM backbone. ATM has the capability to handle the increasing traffic loads on the ARCLAN 2000 that results from these new applications. As it can be seen from Figure 1, ARCLAN 2000 have a total of 32 routers (5 being core routers) each connected to the FDDI backbone via a 100 Mbps link. This network serves 34 different locations by using 34 hubs that are connected to secondary routers. End users are connected to the secondary routers with 10 Mbps links.

Visualization of fluid dynamics at NASA Ames

NASA Technical Reports Server (NTRS)

Watson, Val

1989-01-01

The hardware and software currently used for visualization of fluid dynamics at NASA Ames is described. The software includes programs to create scenes (for example particle traces representing the flow over an aircraft), programs to interactively view the scenes, and programs to control the creation of video tapes and 16mm movies. The hardware includes high performance graphics workstations, a high speed network, digital video equipment, and film recorders.

Atmosphere of Freedom: Sixty Years at the NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Bugos, Glenn E.; Launius, Roger (Technical Monitor)

2000-01-01

Throughout Ames History, four themes prevail: a commitment to hiring the best people; cutting-edge research tools; project management that gets things done faster, better and cheaper; and outstanding research efforts that serve the scientific professions and the nation. More than any other NASA Center, Ames remains shaped by its origins in the NACA (National Advisory Committee for Aeronautics). Not that its missions remain the same. Sure, Ames still houses the world's greatest collection of wind tunnels and simulation facilities, its aerodynamicists remain among the best in the world, and pilots and engineers still come for advice on how to build better aircraft. But that is increasingly part of Ames' past. Ames people have embraced two other missions for its future. First, intelligent systems and information science will help NASA use new tools in supercomputing, networking, telepresence and robotics. Second, astrobiology will explore lore the prospects for life on Earth and beyond. Both new missions leverage Ames long-standing expertise in computation and in the life sciences, as well as its relations with the computing and biotechnology firms working in the Silicon Valley community that has sprung up around the Center. Rather than the NACA missions, it is the NACA culture that still permeates Ames. The Ames way of research management privileges the scientists and engineers working in the laboratories. They work in an atmosphere of freedom, laced with the expectation of integrity and responsibility. Ames researchers are free to define their research goals and define how they contribute to the national good. They are expected to keep their fingers on the pulse of their disciplines, to be ambitious yet frugal in organizing their efforts, and to always test their theories in the laboratory or in the field. Ames' leadership ranks, traditionally, are cultivated within this scientific community. Rather than manage and supervise these researchers, Ames leadership merely guided them, represents them to NASA headquarters and the world outside, then steps out of the way before they get run over.

Report of the Interagency Optical Network Testbeds Workshop 2, NASA Ames Research Center, September 12-14, 2005

NASA Technical Reports Server (NTRS)

2005-01-01

The Optical Network Testbeds Workshop 2 (ONT2), held on September 12-14, 2005, was cosponsored by the Department of Energy Office of Science (DOE/SC) and the National Aeronautics and Space Administration (NASA), in cooperation with the Joint Engineering Team (JET) of the Federal Networking and Information Technology Research and Development (NITRD) Program's Large Scale Networking (LSN) Coordinating Group. The ONT2 workshop was a follow-on to an August 2004 Workshop on Optical Network Testbeds (ONT1). ONT1 recommended actions by the Federal agencies to assure timely development and implementation of optical networking technologies and infrastructure. Hosted by the NASA Ames Research Center in Mountain View, California, the ONT2 workshop brought together representatives of the U.S. advanced research and education (R&E) networks, regional optical networks (RONs), service providers, international networking organizations, and senior engineering and R&D managers from Federal agencies and national research laboratories. Its purpose was to develop a common vision of the optical network technologies, services, infrastructure, and organizations needed to enable widespread use of optical networks; recommend activities for transitioning the optical networking research community and its current infrastructure to leading-edge optical networks over the next three to five years; and present information enabling commercial network infrastructure providers to plan for and use leading-edge optical network services in that time frame.

Effect of Achillea millefolium-loaded nanophytosome in the post-thawing sperm quality and oxidative status of rooster semen.

PubMed

Najafi, Davood; Taheri, Ramezan Ali; Najafi, Abouzar; Rouhollahi, Abbas Abbas; Alvarez-Rodriguez, Manuel

2018-04-17

The aim of this study was to compare the effectiveness of antioxidants including Achillea millefolium extract (AmE) (n0t1.5: 1.5, n0t3: 3 and n0t4.5: 4.5 mg/L) and AmE loaded in nano phytosome (n1t1.5: 1.5, n1t3: 3 and n1t4.5: 4.5 mg/L) in the freezing of Ross 308 rooster semen. Sperm motility (CASA), membrane integrity (HOS test), viability, total abnormality and enzymatic parameters (SOD, CAT and GPx) were assessed after thawing. AmE-loaded nano phytosome at a concentration of 3 mg/l resulted in significantly (P < 0.05) higher total motility (MOT) (73.78 ± 2.92) and at concentrations of 1.5 mg/L and 3 mg/L in progressive motility (PROG) (14.12 ± 0.38, 16.78 ± 0.38) in comparison with the control group (MOT: 58.48 ± 2.92; PROG: 9.08 ± 0.38). Sperm viability (Vi) was higher (P < 0.05) in n1t3 (74.62 ± 1.55) and membrane integrity (Mi) in n0t3 and n1t3 groups (65.91 ± 1.91, 63.73 ± 1.91, respectively) compared to the control groups (Vi: 66.85 ± 1.55; Mi: 53.18 ± 1.91). Moreover, the lowest percentage of MDA was measured in n1t3 group (1.31 ± 0.31). There was no significant difference for SOD and CAT values with the use of various extenders. In conclusion, we suggest that AmE loaded in nano phytosome at 3 mg/l dose can be added to basic extender for improving rooster sperm motility, viability and oxidative stress values during the freezing procedure. Copyright © 2018 Elsevier Inc. All rights reserved.

The IBM PC at NASA Ames

NASA Technical Reports Server (NTRS)

Peredo, James P.

1988-01-01

Like many large companies, Ames relies very much on its computing power to get work done. And, like many other large companies, finding the IBM PC a reliable tool, Ames uses it for many of the same types of functions as other companies. Presentation and clarification needs demand much of graphics packages. Programming and text editing needs require simpler, more-powerful packages. The storage space needed by NASA's scientists and users for the monumental amounts of data that Ames needs to keep demand the best database packages that are large and easy to use. Availability to the Micom Switching Network combines the powers of the IBM PC with the capabilities of other computers and mainframes and allows users to communicate electronically. These four primary capabilities of the PC are vital to the needs of NASA's users and help to continue and support the vast amounts of work done by the NASA employees.

NSI directed to continue SPAN's functions

NASA Technical Reports Server (NTRS)

Rounds, Fred

1991-01-01

During a series of network management retreats in June and July 1990, representatives from NASA Headquarters Codes O and S agreed on networking roles and responsibilities for their respective organizations. The representatives decided that NASA Science Internet (NSI) will assume management of both the Space Physics Analysis Network (SPAN) and the NASA Science Network (NSN). SPAN is now known as the NSI/DECnet, and NSN is now known as the NSI/IP. Some management functions will be distributed between Ames Research Center (ARC) and Goddard Space Flight Center (GSFC). NSI at ARC has the lead role for requirements generation and networking engineering. Advanced Applications and the Network Information Center is being developed at GSFC. GSFC will lead the NSI User Services, but NSI at Ames will continue to provide the User Services during the transition. The transition will be made as transparent as possible for the users. DECnet service will continue, but is now directly managed by NSI at Ames. NSI will continue to work closely with routing center managers at other NASA centers, and has formed a transition team to address the change in management. An NSI/DECnet working group had also been formed as a separate engineering group within NSI to plan the transition to Phase 5, DECnet's approach to Open System Integration (OSI). Transition is not expected for a year or more due to delays in produce releases. Plans to upgrade speeds in tail circuits and the backbone are underway. The proposed baseline service for new connections is up to 56 Kbps; 9.6 Kbps lines will gradually be upgraded as requirements dictate. NSI is in the process of consolidating protocol traffic, tail circuits, and the backbone. Currently NSI's backbone is fractional T1; NSI will go to full T1 service as soon as it is feasible.

Earlinet validation of CATS L2 product

NASA Astrophysics Data System (ADS)

Proestakis, Emmanouil; Amiridis, Vassilis; Kottas, Michael; Marinou, Eleni; Binietoglou, Ioannis; Ansmann, Albert; Wandinger, Ulla; Yorks, John; Nowottnick, Edward; Makhmudov, Abduvosit; Papayannis, Alexandros; Pietruczuk, Aleksander; Gialitaki, Anna; Apituley, Arnoud; Muñoz-Porcar, Constantino; Bortoli, Daniele; Dionisi, Davide; Althausen, Dietrich; Mamali, Dimitra; Balis, Dimitris; Nicolae, Doina; Tetoni, Eleni; Luigi Liberti, Gian; Baars, Holger; Stachlewska, Iwona S.; Voudouri, Kalliopi-Artemis; Mona, Lucia; Mylonaki, Maria; Rita Perrone, Maria; João Costa, Maria; Sicard, Michael; Papagiannopoulos, Nikolaos; Siomos, Nikolaos; Burlizzi, Pasquale; Engelmann, Ronny; Abdullaev, Sabur F.; Hofer, Julian; Pappalardo, Gelsomina

2018-04-01

The Cloud-Aerosol Transport System (CATS) onboard the International Space Station (ISS), is a lidar system providing vertically resolved aerosol and cloud profiles since February 2015. In this study, the CATS aerosol product is validated against the aerosol profiles provided by the European Aerosol Research Lidar Network (EARLINET). This validation activity is based on collocated CATS-EARLINET measurements and the comparison of the particle backscatter coefficient at 1064nm.

Flight test evaluation of the E-systems Differential GPS category 3 automatic landing system

NASA Technical Reports Server (NTRS)

Kaufmann, David N.; Mcnally, B. David

1995-01-01

Test flights were conducted to evaluate the capability of Differential Global Positioning System (DGPS) to provide the accuracy and integrity required for International Civil Aviation Organization (ICAO) Category (CAT) III precision approach and landings. These test flights were part of a Federal Aviation Administration (FAA) program to evaluate the technical feasibility of using DGPS based technology for CAT III precision approach and landing applications. An IAI Westwind 1124 aircraft (N24RH) was equipped with DGPS receiving equipment and additional computing capability provided by E-Systems. The test flights were conducted at NASA Ames Research Center's Crows Landing Flight Facility, Crows Landing, California. The flight test evaluation was based on completing 100 approaches and landings. The navigation sensor error accuracy requirements were based on ICAO requirements for the Microwave Landing System (MLS). All of the approaches and landings were evaluated against ground truth reference data provided by a laser tracker. Analysis of these approaches and landings shows that the E-Systems DGPS system met the navigation sensor error requirements for a successful approach and landing 98 out of 100 approaches and landings, based on the requirements specified in the FAA CAT III Level 2 Flight Test Plan. In addition, the E-Systems DGPS system met the integrity requirements for a successful approach and landing or stationary trial for all 100 approaches and landings and all ten stationary trials, based on the requirements specified in the FAA CAT III Level 2 Flight Test Plan.

Chimera-like states in a neuronal network model of the cat brain

NASA Astrophysics Data System (ADS)

Santos, M. S.; Szezech, J. D.; Borges, F. S.; Iarosz, K. C.; Caldas, I. L.; Batista, A. M.; Viana, R. L.; Kurths, J.

2017-08-01

Neuronal systems have been modeled by complex networks in different description levels. Recently, it has been verified that networks can simultaneously exhibit one coherent and other incoherent domain, known as chimera states. In this work, we study the existence of chimera states in a network considering the connectivity matrix based on the cat cerebral cortex. The cerebral cortex of the cat can be separated in 65 cortical areas organised into the four cognitive regions: visual, auditory, somatosensory-motor and frontolimbic. We consider a network where the local dynamics is given by the Hindmarsh-Rose model. The Hindmarsh-Rose equations are a well known model of neuronal activity that has been considered to simulate membrane potential in neuron. Here, we analyse under which conditions chimera states are present, as well as the affects induced by intensity of coupling on them. We observe the existence of chimera states in that incoherent structure can be composed of desynchronised spikes or desynchronised bursts. Moreover, we find that chimera states with desynchronised bursts are more robust to neuronal noise than with desynchronised spikes.

Pilots Rate Augmented Generalized Predictive Control for Reconfiguration

NASA Technical Reports Server (NTRS)

Soloway, Don; Haley, Pam

2004-01-01

The objective of this paper is to report the results from the research being conducted in reconfigurable fight controls at NASA Ames. A study was conducted with three NASA Dryden test pilots to evaluate two approaches of reconfiguring an aircraft's control system when failures occur in the control surfaces and engine. NASA Ames is investigating both a Neural Generalized Predictive Control scheme and a Neural Network based Dynamic Inverse controller. This paper highlights the Predictive Control scheme where a simple augmentation to reduce zero steady-state error led to the neural network predictor model becoming redundant for the task. Instead of using a neural network predictor model, a nominal single point linear model was used and then augmented with an error corrector. This paper shows that the Generalized Predictive Controller and the Dynamic Inverse Neural Network controller perform equally well at reconfiguration, but with less rate requirements from the actuators. Also presented are the pilot ratings for each controller for various failure scenarios and two samples of the required control actuation during reconfiguration. Finally, the paper concludes by stepping through the Generalized Predictive Control's reconfiguration process for an elevator failure.

Network Computer Technology. Phase I: Viability and Promise within NASA's Desktop Computing Environment

NASA Technical Reports Server (NTRS)

Paluzzi, Peter; Miller, Rosalind; Kurihara, West; Eskey, Megan

1998-01-01

Over the past several months, major industry vendors have made a business case for the network computer as a win-win solution toward lowering total cost of ownership. This report provides results from Phase I of the Ames Research Center network computer evaluation project. It identifies factors to be considered for determining cost of ownership; further, it examines where, when, and how network computer technology might fit in NASA's desktop computing architecture.

Evaluation of supervised machine-learning algorithms to distinguish between inflammatory bowel disease and alimentary lymphoma in cats.

PubMed

Awaysheh, Abdullah; Wilcke, Jeffrey; Elvinger, François; Rees, Loren; Fan, Weiguo; Zimmerman, Kurt L

2016-11-01

Inflammatory bowel disease (IBD) and alimentary lymphoma (ALA) are common gastrointestinal diseases in cats. The very similar clinical signs and histopathologic features of these diseases make the distinction between them diagnostically challenging. We tested the use of supervised machine-learning algorithms to differentiate between the 2 diseases using data generated from noninvasive diagnostic tests. Three prediction models were developed using 3 machine-learning algorithms: naive Bayes, decision trees, and artificial neural networks. The models were trained and tested on data from complete blood count (CBC) and serum chemistry (SC) results for the following 3 groups of client-owned cats: normal, inflammatory bowel disease (IBD), or alimentary lymphoma (ALA). Naive Bayes and artificial neural networks achieved higher classification accuracy (sensitivities of 70.8% and 69.2%, respectively) than the decision tree algorithm (63%, p < 0.0001). The areas under the receiver-operating characteristic curve for classifying cases into the 3 categories was 83% by naive Bayes, 79% by decision tree, and 82% by artificial neural networks. Prediction models using machine learning provided a method for distinguishing between ALA-IBD, ALA-normal, and IBD-normal. The naive Bayes and artificial neural networks classifiers used 10 and 4 of the CBC and SC variables, respectively, to outperform the C4.5 decision tree, which used 5 CBC and SC variables in classifying cats into the 3 classes. These models can provide another noninvasive diagnostic tool to assist clinicians with differentiating between IBD and ALA, and between diseased and nondiseased cats. © 2016 The Author(s).

Software Sharing Enables Smarter Content Management

NASA Technical Reports Server (NTRS)

2007-01-01

In 2004, NASA established a technology partnership with Xerox Corporation to develop high-tech knowledge management systems while providing new tools and applications that support the Vision for Space Exploration. In return, NASA provides research and development assistance to Xerox to progress its product line. The first result of the technology partnership was a new system called the NX Knowledge Network (based on Xerox DocuShare CPX). Created specifically for NASA's purposes, this system combines Netmark-practical database content management software created by the Intelligent Systems Division of NASA's Ames Research Center-with complementary software from Xerox's global research centers and DocuShare. NX Knowledge Network was tested at the NASA Astrobiology Institute, and is widely used for document management at Ames, Langley Research Center, within the Mission Operations Directorate at Johnson Space Center, and at the Jet Propulsion Laboratory, for mission-related tasks.

The Laplacian spectrum of neural networks

PubMed Central

de Lange, Siemon C.; de Reus, Marcel A.; van den Heuvel, Martijn P.

2014-01-01

The brain is a complex network of neural interactions, both at the microscopic and macroscopic level. Graph theory is well suited to examine the global network architecture of these neural networks. Many popular graph metrics, however, encode average properties of individual network elements. Complementing these “conventional” graph metrics, the eigenvalue spectrum of the normalized Laplacian describes a network's structure directly at a systems level, without referring to individual nodes or connections. In this paper, the Laplacian spectra of the macroscopic anatomical neuronal networks of the macaque and cat, and the microscopic network of the Caenorhabditis elegans were examined. Consistent with conventional graph metrics, analysis of the Laplacian spectra revealed an integrative community structure in neural brain networks. Extending previous findings of overlap of network attributes across species, similarity of the Laplacian spectra across the cat, macaque and C. elegans neural networks suggests a certain level of consistency in the overall architecture of the anatomical neural networks of these species. Our results further suggest a specific network class for neural networks, distinct from conceptual small-world and scale-free models as well as several empirical networks. PMID:24454286

Flight test evaluation of the Stanford University/United Airlines differential GPS Category 3 automatic landing system

NASA Technical Reports Server (NTRS)

Kaufmann, David N.; Ncnally, B. David

1995-01-01

Test flights were conducted to evaluate the capability of Differential Global Positioning System (DGPS) to provide the accuracy and integrity required for International Civil Aviation Organization (ICAO) Category (CAT) 3 precision approach and landings. These test flights were part of a Federal Aviation Administration (FAA) program to evaluate the technical feasibility of using DGPS based technology for CAT 3 precision approach and landing applications. A United Airlines Boeing 737-300 (N304UA) was equipped with DGPS receiving equipment and additional computing capability provided by Stanford University. The test flights were conducted at NASA Ames Research Center's Crows Landing Flight Facility, Crows Landing, California. The flight test evaluation was based on completing 100 approaches and autolandings; 90 touch and go, and 10 terminating with a full stop. Two types of accuracy requirements were evaluated: 1) Total system error, based on the Required Navigation Performance (RNP), and 2) Navigation sensor error, based on ICAO requirements for the Microwave Landing System (MLS). All of the approaches and autolandings were evaluated against ground truth reference data provided by a laser tracker. Analysis of these approaches and autolandings shows that the Stanford University/United Airlines system met the requirements for a successful approach and autolanding 98 out of 100 approaches and autolandings, based on the total system error requirements as specified in the FAA CAT 3 Level 2 Flight Test Plan.

NASA/ARC proposed training in intelligent control

NASA Technical Reports Server (NTRS)

Berenji, Hamid R.

1990-01-01

Viewgraphs on NASA Ames Research Center proposed training in intelligent control was presented. Topics covered include: fuzzy logic control; neural networks in control; artificial intelligence in control; hybrid approaches; hands on experience; and fuzzy controllers.

Integration of a MicroCAT Propulsion System and a PhoneSat Bus into a 1.5U CubeSat

NASA Technical Reports Server (NTRS)

Agasid, Elwood Floyd; Perez, Andres Dono; Gazulla, Oriol Tintore; Trinh, Greenfield Tran; Uribe, Eddie Anthony; Keidar, Michael; Haque, Samudra; Teel, George

2014-01-01

NASA Ames Research Center and the George Washington University have developed an electric propulsion subsystem that can be integrated into the PhoneSat bus. Experimental tests have shown a reliable performance by firing three different thrusters at various frequencies in vacuum conditions. The three thrusters were controlled by a SmartPhone that was running the PhoneSat software. The subsystem is fully operational and it requires low average power to function (about 0.1 W). The interface consists of a microcontroller that sends a trigger pulses to the PPU (Plasma Processing Unit), which is responsible for the thruster operation. Frequencies ranging from 1 to 50Hz have been tested, showing a strong flexibility. A SmartPhone acts as the main user interface for the selection of commands that control the entire system. The micro cathode arc thruster MicroCAT provides a high 1(sub sp) of 3000s that allows a 4kg satellite to obtain a (delta)V of 300m/s. The system mass is only 200g with a total of volume of 200(cu cm). The propellant is based on a solid cylinder made of Titanium, which is the cathode at the same time. This simplicity in the design avoids miniaturization and manufacturing problems. The characteristics of this thruster allow an array of MicroCATs to perform attitude control and orbital correcton maneuvers that will open the door for the implementation of an extensive collection of new mission concepts and space applications for CubeSats. NASA Ames is currently working on the integration of the system to fit the thrusters and PPU inside a 1.5U CubeSat together with the PhoneSat bus into a 1.5U CubeSat. This satellite is intended to be deployed from the ISS in 2015 and test the functionality of the thrusters by spinning the satellite around its long axis and measure the rotational speed with the phone byros. This test flight will raise the TRL of the propulsion system from 5 to 7 and will be a first test for further CubeSats with propulsion systems, a key subsystem for long duration or interplanetary CubeSat missions.

Statistical mechanics of a cat's cradle

NASA Astrophysics Data System (ADS)

Shen, Tongye; Wolynes, Peter G.

2006-11-01

It is believed that, much like a cat's cradle, the cytoskeleton can be thought of as a network of strings under tension. We show that both regular and random bond-disordered networks having bonds that buckle upon compression exhibit a variety of phase transitions as a function of temperature and extension. The results of self-consistent phonon calculations for the regular networks agree very well with computer simulations at finite temperature. The analytic theory also yields a rigidity onset (mechanical percolation) and the fraction of extended bonds for random networks. There is very good agreement with the simulations by Delaney et al (2005 Europhys. Lett. 72 990). The mean field theory reveals a nontranslationally invariant phase with self-generated heterogeneity of tautness, representing 'antiferroelasticity'.

Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network

PubMed Central

Widhalm, Joshua R.; Gutensohn, Michael; Yoo, Heejin; Adebesin, Funmilayo; Qian, Yichun; Guo, Longyun; Jaini, Rohit; Lynch, Joseph H.; McCoy, Rachel M.; Shreve, Jacob T.; Thimmapuram, Jyothi; Rhodes, David; Morgan, John A.; Dudareva, Natalia

2015-01-01

In addition to proteins, L-phenylalanine is a versatile precursor for thousands of plant metabolites. Production of phenylalanine-derived compounds is a complex multi-compartmental process using phenylalanine synthesized predominantly in plastids as precursor. The transporter(s) exporting phenylalanine from plastids, however, remains unknown. Here, a gene encoding a Petunia hybrida plastidial cationic amino-acid transporter (PhpCAT) functioning in plastidial phenylalanine export is identified based on homology to an Escherichia coli phenylalanine transporter and co-expression with phenylalanine metabolic genes. Radiolabel transport assays show that PhpCAT exports all three aromatic amino acids. PhpCAT downregulation and overexpression result in decreased and increased levels, respectively, of phenylalanine-derived volatiles, as well as phenylalanine, tyrosine and their biosynthetic intermediates. Metabolic flux analysis reveals that flux through the plastidial phenylalanine biosynthetic pathway is reduced in PhpCAT RNAi lines, suggesting that the rate of phenylalanine export from plastids contributes to regulating flux through the aromatic amino-acid network. PMID:26356302

Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Widhalm, Joshua R.; Gutensohn, Michael; Yoo, Heejin

In addition to proteins, L-phenylalanine is a versatile precursor for thousands of plant metabolites. Production of phenylalanine-derived compounds is a complex multi-compartmental process using phenylalanine synthesized predominantly in plastids as precursor. The transporter(s) exporting phenylalanine from plastids, however, remains unknown. Here, a gene encoding a Petunia hybrida plastidial cationic amino-acid transporter (PhpCAT) functioning in plastidial phenylalanine export is identified based on homology to an Escherichia coli phenylalanine transporter and co-expression with phenylalanine metabolic genes. Radiolabel transport assays show that PhpCAT exports all three aromatic amino acids. PhpCAT downregulation and overexpression result in decreased and increased levels, respectively, of phenylalanine-derived volatiles,more » as well as phenylalanine, tyrosine and their biosynthetic intermediates. Metabolic flux analysis reveals that flux through the plastidial phenylalanine biosynthetic pathway is reduced in PhpCAT RNAi lines, suggesting that the rate of phenylalanine export from plastids contributes to regulating flux through the aromatic amino-acid network.« less

Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network

DOE PAGES

Widhalm, Joshua R.; Gutensohn, Michael; Yoo, Heejin; ...

2015-09-10

In addition to proteins, L-phenylalanine is a versatile precursor for thousands of plant metabolites. Production of phenylalanine-derived compounds is a complex multi-compartmental process using phenylalanine synthesized predominantly in plastids as precursor. The transporter(s) exporting phenylalanine from plastids, however, remains unknown. Here, a gene encoding a Petunia hybrida plastidial cationic amino-acid transporter (PhpCAT) functioning in plastidial phenylalanine export is identified based on homology to an Escherichia coli phenylalanine transporter and co-expression with phenylalanine metabolic genes. Radiolabel transport assays show that PhpCAT exports all three aromatic amino acids. PhpCAT downregulation and overexpression result in decreased and increased levels, respectively, of phenylalanine-derived volatiles,more » as well as phenylalanine, tyrosine and their biosynthetic intermediates. Metabolic flux analysis reveals that flux through the plastidial phenylalanine biosynthetic pathway is reduced in PhpCAT RNAi lines, suggesting that the rate of phenylalanine export from plastids contributes to regulating flux through the aromatic amino-acid network.« less

Composite Social Network for Predicting Mobile Apps Installation

DTIC Science & Technology

2011-06-02

analysis used by social scientists such as matched sample estimation (Aral, Muchnik, and Sundararajan 2009) are only for identifying network effects and...ar X iv :1 10 6. 03 59 v1 [ cs .S I] 2 J un 2 01 1 Composite Social Network for Predicting Mobile Apps Installation Wei Pan and Nadav Aharony...and Alex (Sandy) Pentland MIT Media Laboratory 20 Ames Street Cambridge, Massachusetts 02139 Abstract We have carefully instrumented a large portion of

Verification and Validation of Neural Networks for Aerospace Systems

NASA Technical Reports Server (NTRS)

Mackall, Dale; Nelson, Stacy; Schumman, Johann; Clancy, Daniel (Technical Monitor)

2002-01-01

The Dryden Flight Research Center V&V working group and NASA Ames Research Center Automated Software Engineering (ASE) group collaborated to prepare this report. The purpose is to describe V&V processes and methods for certification of neural networks for aerospace applications, particularly adaptive flight control systems like Intelligent Flight Control Systems (IFCS) that use neural networks. This report is divided into the following two sections: 1) Overview of Adaptive Systems; and 2) V&V Processes/Methods.

Verification and Validation of Neural Networks for Aerospace Systems

NASA Technical Reports Server (NTRS)

Mackall, Dale; Nelson, Stacy; Schumann, Johann

2002-01-01

The Dryden Flight Research Center V&V working group and NASA Ames Research Center Automated Software Engineering (ASE) group collaborated to prepare this report. The purpose is to describe V&V processes and methods for certification of neural networks for aerospace applications, particularly adaptive flight control systems like Intelligent Flight Control Systems (IFCS) that use neural networks. This report is divided into the following two sections: Overview of Adaptive Systems and V&V Processes/Methods.

Neural processing of gravity information

NASA Technical Reports Server (NTRS)

Schor, Robert H.

1992-01-01

The goal of this project was to use the linear acceleration capabilities of the NASA Vestibular Research Facility (VRF) at Ames Research Center to directly examine encoding of linear accelerations in the vestibular system of the cat. Most previous studies, including my own, have utilized tilt stimuli, which at very low frequencies (e.g., 'static tilt') can be considered a reasonably pure linear acceleration (e.g., 'down'); however, higher frequencies of tilt, necessary for understanding the dynamic processing of linear acceleration information, necessarily involves rotations which can stimulate the semicircular canals. The VRF, particularly the Long Linear Sled, has promise to provide controlled pure linear accelerations at a variety of stimulus frequencies, with no confounding angular motion.

Multistate matrix population model to assess the contributions and impacts on population abundance of domestic cats in urban areas including owned cats, unowned cats, and cats in shelters

PubMed Central

Coe, Jason B.

2018-01-01

Concerns over cat homelessness, over-taxed animal shelters, public health risks, and environmental impacts has raised attention on urban-cat populations. To truly understand cat population dynamics, the collective population of owned cats, unowned cats, and cats in the shelter system must be considered simultaneously because each subpopulation contributes differently to the overall population of cats in a community (e.g., differences in neuter rates, differences in impacts on wildlife) and cats move among categories through human interventions (e.g., adoption, abandonment). To assess this complex socio-ecological system, we developed a multistate matrix model of cats in urban areas that include owned cats, unowned cats (free-roaming and feral), and cats that move through the shelter system. Our model requires three inputs—location, number of human dwellings, and urban area—to provide testable predictions of cat abundance for any city in North America. Model-predicted population size of unowned cats in seven Canadian cities were not significantly different than published estimates (p = 0.23). Model-predicted proportions of sterile feral cats did not match observed sterile cat proportions for six USA cities (p = 0.001). Using a case study from Guelph, Ontario, Canada, we compared model-predicted to empirical estimates of cat abundance in each subpopulation and used perturbation analysis to calculate relative sensitivity of vital rates to cat abundance to demonstrate how management or mismanagement in one portion of the population could have repercussions across all portions of the network. Our study provides a general framework to consider cat population abundance in urban areas and, with refinement that includes city-specific parameter estimates and modeling, could provide a better understanding of population dynamics of cats in our communities. PMID:29489854

Multistate matrix population model to assess the contributions and impacts on population abundance of domestic cats in urban areas including owned cats, unowned cats, and cats in shelters.

PubMed

Flockhart, D T Tyler; Coe, Jason B

2018-01-01

Concerns over cat homelessness, over-taxed animal shelters, public health risks, and environmental impacts has raised attention on urban-cat populations. To truly understand cat population dynamics, the collective population of owned cats, unowned cats, and cats in the shelter system must be considered simultaneously because each subpopulation contributes differently to the overall population of cats in a community (e.g., differences in neuter rates, differences in impacts on wildlife) and cats move among categories through human interventions (e.g., adoption, abandonment). To assess this complex socio-ecological system, we developed a multistate matrix model of cats in urban areas that include owned cats, unowned cats (free-roaming and feral), and cats that move through the shelter system. Our model requires three inputs-location, number of human dwellings, and urban area-to provide testable predictions of cat abundance for any city in North America. Model-predicted population size of unowned cats in seven Canadian cities were not significantly different than published estimates (p = 0.23). Model-predicted proportions of sterile feral cats did not match observed sterile cat proportions for six USA cities (p = 0.001). Using a case study from Guelph, Ontario, Canada, we compared model-predicted to empirical estimates of cat abundance in each subpopulation and used perturbation analysis to calculate relative sensitivity of vital rates to cat abundance to demonstrate how management or mismanagement in one portion of the population could have repercussions across all portions of the network. Our study provides a general framework to consider cat population abundance in urban areas and, with refinement that includes city-specific parameter estimates and modeling, could provide a better understanding of population dynamics of cats in our communities.

Populating the Advanced National Seismic System Comprehensive Earthquake Catalog

NASA Astrophysics Data System (ADS)

Earle, P. S.; Perry, M. R.; Andrews, J. R.; Withers, M. M.; Hellweg, M.; Kim, W. Y.; Shiro, B.; West, M. E.; Storchak, D. A.; Pankow, K. L.; Huerfano Moreno, V. A.; Gee, L. S.; Wolfe, C. J.

2016-12-01

The U.S. Geological Survey maintains a repository of earthquake information produced by networks in the Advanced National Seismic System with additional data from the ISC-GEM catalog and many non-U.S. networks through their contributions to the National Earthquake Information Center PDE bulletin. This Comprehensive Catalog (ComCat) provides a unified earthquake product while preserving attribution and contributor information. ComCat contains hypocenter and magnitude information with supporting phase arrival-time and amplitude measurements (when available). Higher-level products such as focal mechanisms, earthquake slip models, "Did You Feel It?" reports, ShakeMaps, PAGER impact estimates, earthquake summary posters, and tectonic summaries are also included. ComCat is updated as new events are processed and the catalog can be accesed at http://earthquake.usgs.gov/earthquakes/search/. Throughout the past few years, a concentrated effort has been underway to expand ComCat by integrating global and regional historic catalogs. The number of earthquakes in ComCat has more than doubled in the past year and it presently contains over 1.6 million earthquake hypocenters. We will provide an overview of catalog contents and a detailed description of numerous tools and semi-automated quality-control procedures developed to uncover errors including systematic magnitude biases, missing time periods, duplicate postings for the same events, and incorrectly associated events.

ARC-2010-ACD10-0243-002

NASA Image and Video Library

2010-12-22

Wireless crop water monitoring project: Dr. Chris Lund and Forrest Melton, California State University Monterey Bay research scientists who work at NASA Ames Research Center, check data being returned from a wireless soil moisture monitoring network, installed in an agricultural field. Data from the soil moisture sensor network will be used to assist in interpretation of the satellite estimates of crop water demand. Image of courtesy of Forrest S. Melton

Microcomputer Network for Computerized Adaptive Testing (CAT). [Final Report, FY81-83].

ERIC Educational Resources Information Center

Quan, Baldwin; And Others

Computerized adaptive testing (CAT) offers the opportunity to replace paper-and-pencil aptitude tests such as the Armed Services Vocational Aptitude Battery with shorter, more accurate, and more secure computer-administered tests. Its potential advantages need to be verified by experimental administration of automated tests to military recruit…

What WorldCat (The OCLC Online Union Catalog) Means to Me.

ERIC Educational Resources Information Center

Bishop, George E.; Case, Donald O.; Hassan, Patricia L.; Smith, Jeanette C.; Zhang, Daofu

1998-01-01

Marking the 25th anniversary (August 26, 1996) of WorldCat (the Online Computer Library Center (OCLC) Online Union Catalog) OCLC and the U.S. regional networks sponsored an essay contest for librarians and library users to write essays describing their impressions of the OCLC Online Union Catalog. Four prize-winning essays from Michigan, Kentucky,…

Pilot project for a hybrid road-flooding forecasting system on Squaw Creek.

DOT National Transportation Integrated Search

2014-09-01

A network of 25 sonic stage sensors were deployed in the Squaw Creek basin upstream from Ames Iowa to determine : if the state-of-the-art distributed hydrological model CUENCAS can produce reliable information for all road crossings : including those...

Development of an integrated set of research facilities for the support of research flight test

NASA Technical Reports Server (NTRS)

Moore, Archie L.; Harney, Constance D.

1988-01-01

The Ames-Dryden Flight Research Facility (DFRF) serves as the site for high-risk flight research on many one-of-a-kind test vehicles like the X-29A advanced technology demonstrator, F-16 advanced fighter technology integration (AFTI), AFTI F-111 mission adaptive wing, and F-18 high-alpha research vehicle (HARV). Ames-Dryden is on a section of the historic Muroc Range. The facility is oriented toward the testing of high-performance aircraft, as shown by its part in the development of the X-series aircraft. Given the cost of research flight tests and the complexity of today's systems-driven aircraft, an integrated set of ground support experimental facilities is a necessity. In support of the research flight test of highly advanced test beds, the DFRF is developing a network of facilities to expedite the acquisition and distribution of flight research data to the researcher. The network consists of an array of experimental ground-based facilities and systems as nodes and the necessary telecommunications paths to pass research data and information between these facilities. This paper presents the status of the current network, an overview of current developments, and a prospectus on future major enhancements.

Live-cell imaging of conidial anastomosis tube fusion during colony initiation in Fusarium oxysporum

PubMed Central

Kurian, Smija M.; Di Pietro, Antonio

2018-01-01

Fusarium oxysporum exhibits conidial anastomosis tube (CAT) fusion during colony initiation to form networks of conidial germlings. Here we determined the optimal culture conditions for this fungus to undergo CAT fusion between microconidia in liquid medium. Extensive high resolution, confocal live-cell imaging was performed to characterise the different stages of CAT fusion, using genetically encoded fluorescent labelling and vital fluorescent organelle stains. CAT homing and fusion were found to be dependent on adhesion to the surface, in contrast to germ tube development which occurs in the absence of adhesion. Staining with fluorescently labelled concanavalin A indicated that the cell wall composition of CATs differs from that of microconidia and germ tubes. The movement of nuclei, mitochondria, vacuoles and lipid droplets through fused germlings was observed by live-cell imaging. PMID:29734342

Live-cell imaging of conidial anastomosis tube fusion during colony initiation in Fusarium oxysporum.

PubMed

Kurian, Smija M; Di Pietro, Antonio; Read, Nick D

2018-01-01

Fusarium oxysporum exhibits conidial anastomosis tube (CAT) fusion during colony initiation to form networks of conidial germlings. Here we determined the optimal culture conditions for this fungus to undergo CAT fusion between microconidia in liquid medium. Extensive high resolution, confocal live-cell imaging was performed to characterise the different stages of CAT fusion, using genetically encoded fluorescent labelling and vital fluorescent organelle stains. CAT homing and fusion were found to be dependent on adhesion to the surface, in contrast to germ tube development which occurs in the absence of adhesion. Staining with fluorescently labelled concanavalin A indicated that the cell wall composition of CATs differs from that of microconidia and germ tubes. The movement of nuclei, mitochondria, vacuoles and lipid droplets through fused germlings was observed by live-cell imaging.

The Situation Awareness Weighted Network (SAWN) Model

DTIC Science & Technology

2014-06-01

Administration Task Load Index (NASA- TLX ), a validated research instrument [Human Performance Research Group 1988]. The participants were asked to rate their...analysis”, Human Factors 40(2): 254–276. 17 Human Performance Research Group (1988) NASA- TLX , NASA Ames Research Center, Moffett Field, CA. Jin, Y. and

Review of gunshot injuries in cats and dogs and utility of a triage scoring system to predict short-term outcome: 37 cases (2003-2008).

PubMed

Olsen, Lisa E; Streeter, Elizabeth M; DeCook, Rhonda R

2014-10-15

To describe the signalment, wound characteristics, and treatment of gunshot injuries in cats and dogs in urban and rural environments, and to evaluate the utility of the animal trauma triage (ATT) score as an early predictor of survival to discharge from the hospital. Retrospective case series. 29 dogs and 8 cats. Medical records of cats and dogs evaluated for gunshot wounds from 2003 and 2008 at a private urban referral practice in Cedar Rapids, Iowa, and an urban veterinary teaching hospital in Ames, Iowa, were reviewed. Information collected included signalment, chief reason for evaluation, circumstance of the injury, general physical examination findings, wound characteristics, treatments provided, cost of care, survival to discharge from the hospital (yes vs no), and duration of hospital stay. For each animal, ATT scores were calculated and evaluated as a prognostic tool. 37 animals met study inclusion criteria. Animals with higher ATT scores had a greater likelihood of poor outcome following gunshot injury. Animals with higher ATT scores, classified as low (< 4.5) or high (> 4.5), were found to have a longer duration of stay, classified as zero (0 days), short (1 to 3 days), or long (> 3 days). Young male dogs generally considered working breeds were overrepresented (29/37 [78.4%]). A preference for low-velocity, low-kinetic-energy firearms was identified (19/37 [52%]). The most numerous wounds were those inflicted to the limbs (12/37 [32.4%]), during low-visibility hours or hunting excursions. Calculated ATT scores on admission were higher in animals requiring blood products or surgical procedures and in nonsurvivors. Results of the present study suggested that regional preferences in breed ownership and firearm choice are responsible for variation in gunshot injury characteristics and management in animals sustaining injuries in rural and urban settings in Iowa. In cats and dogs, calculation of an ATT score may provide a useful predictor of the need for surgery or blood products, duration of stay, and likelihood of survival to discharge from the hospital.

Modeling of the Space Station Freedom data management system

NASA Technical Reports Server (NTRS)

Johnson, Marjory J.

1990-01-01

The Data Management System (DMS) is the information and communications system onboard Space Station Freedom (SSF). Extensive modeling of the DMS is being conducted throughout NASA to aid in the design and development of this vital system. Activities discussed at NASA Ames Research Center to model the DMS network infrastructure are discussed with focus on the modeling of the Fiber Distributed Data Interface (FDDI) token-ring protocol and experimental testbedding of networking aspects of the DMS.

Research Institute for Advanced Computer Science

NASA Technical Reports Server (NTRS)

Gross, Anthony R. (Technical Monitor); Leiner, Barry M.

2000-01-01

The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. RIACS is located at the NASA Ames Research Center. It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in the year 2002. Ames has been designated NASA's Center of Excellence in Information Technology. In this capacity, Ames is charged with the responsibility to build an Information Technology Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA Ames and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of information technology research necessary to meet the future challenges of NASA missions: (1) Automated Reasoning for Autonomous Systems. Techniques are being developed enabling spacecraft that will be self-guiding and self-correcting to the extent that they will require little or no human intervention. Such craft will be equipped to independently solve problems as they arise, and fulfill their missions with minimum direction from Earth; (2) Human-Centered Computing. Many NASA missions require synergy between humans and computers, with sophisticated computational aids amplifying human cognitive and perceptual abilities; (3) High Performance Computing and Networking. Advances in the performance of computing and networking continue to have major impact on a variety of NASA endeavors, ranging from modeling and simulation to data analysis of large datasets to collaborative engineering, planning and execution. In addition, RIACS collaborates with NASA scientists to apply information technology research to a variety of NASA application domains. RIACS also engages in other activities, such as workshops, seminars, and visiting scientist programs, designed to encourage and facilitate collaboration between the university and NASA information technology research communities.

Study of Tools for Network Discovery and Network Mapping

DTIC Science & Technology

2003-11-01

connected to the switch. iv. Accessibility of historical data and event data In general, network discovery tools keep a history of the collected...has the following software dependencies: - Java Virtual machine 76 - Perl modules - RRD Tool - TomCat - PostgreSQL STRENGTHS AND...systems - provide a simple view of the current network status - generate alarms on status change - generate history of status change VISUAL MAP

Efficiently explore the energy landscape of proteins in molecular dynamics simulations by amplifying collective motions

NASA Astrophysics Data System (ADS)

He, Jianbin; Zhang, Zhiyong; Shi, Yunyu; Liu, Haiyan

2003-08-01

We describe a method for efficient sampling of the energy landscape of a protein in atomic molecular dynamics simulations. A simulation is divided into alternatively occurring relaxation phases and excitation phases. In the relaxation phase (conventional simulation), we use a frequently updated reference structure and deviations from this reference structure to mark whether the system has been trapped in a local minimum. In that case, the simulation enters the excitation phase, during which a few slow collective modes of the system are coupled to a higher temperature bath. After the system has escaped from the minimum (also judged by deviations from the reference structure) the simulation reenters the relaxation phase. The collective modes are obtained from a coarse-grained Gaussian elastic network model. The scheme, which we call ACM-AME (amplified collective motion-assisted minimum escaping), is compared with conventional simulations as well as an alternative scheme that elevates the temperature of all degrees of freedom during the excitation phase (amplified overall motion-assisted minimum escaping, or AOM-AME). Comparison is made using simulations on four peptides starting from non-native extended or all helical structures. In terms of sampling low energy conformations and continuously sampling new conformations throughout a simulation, the ACM-AME scheme demonstrates very good performance while the AOM-AME scheme shows little improvement upon conventional simulations. Limited success is achieved in producing structures close to the native structures of the peptides: for an S-peptide analog, the ACM-AME approach is able to reproduce its native helical structure, and starting from an all-helical structure of the villin headpiece subdomain (HP-36) in implicit solvent, two out of three 150 ns ACM-AME runs are able to sample structures with 3-4 Å backbone root-mean-square deviations from the nuclear magnetic resonance structure of the protein.

An automated calibration laboratory - Requirements and design approach

NASA Technical Reports Server (NTRS)

O'Neil-Rood, Nora; Glover, Richard D.

1990-01-01

NASA's Dryden Flight Research Facility (Ames-Dryden), operates a diverse fleet of research aircraft which are heavily instrumented to provide both real time data for in-flight monitoring and recorded data for postflight analysis. Ames-Dryden's existing automated calibration (AUTOCAL) laboratory is a computerized facility which tests aircraft sensors to certify accuracy for anticipated harsh flight environments. Recently, a major AUTOCAL lab upgrade was initiated; the goal of this modernization is to enhance productivity and improve configuration management for both software and test data. The new system will have multiple testing stations employing distributed processing linked by a local area network to a centralized database. The baseline requirements for the new AUTOCAL lab and the design approach being taken for its mechanization are described.

Anti-Hassle Chip

NASA Technical Reports Server (NTRS)

1998-01-01

With assistance from NASA's Ames Research Center, the iTV Corporation has developed a full custom microprocessor that enables access to the Internet through a $49 device. The microprocessor is supported with a compliment of design tools for customization and adaptation as either a licensable core or as a complete microprocessor. Other uses include cell phones, DVD (digital versatile disk) players, cable modems, video conferencing equipment, digital cameras, wireless LANs (Local Area Network) and WANs (Wide Area Network). iTV continues to design new, low-cost consumer products.

The Aerospace Energy Systems Laboratory: A BITBUS networking application

NASA Technical Reports Server (NTRS)

Glover, Richard D.; Oneill-Rood, Nora

1989-01-01

The NASA Ames-Dryden Flight Research Facility developed a computerized aircraft battery servicing facility called the Aerospace Energy Systems Laboratory (AESL). This system employs distributed processing with communications provided by a 2.4-megabit BITBUS local area network. Customized handlers provide real time status, remote command, and file transfer protocols between a central system running the iRMX-II operating system and ten slave stations running the iRMX-I operating system. The hardware configuration and software components required to implement this BITBUS application are required.

Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers*

PubMed Central

Panwar, Preety; Du, Xin; Sharma, Vidhu; Lamour, Guillaume; Castro, Mickael; Li, Hongbin; Brömme, Dieter

2013-01-01

Excessive cathepsin K (catK)-mediated turnover of fibrillar type I and II collagens in bone and cartilage leads to osteoporosis and osteoarthritis. However, little is known about how catK degrades compact collagen macromolecules. The present study is aimed to explore the structural and mechanical consequences of collagen fiber degradation by catK. Mouse tail type I collagen fibers were incubated with either catK or non-collagenase cathepsins. Methods used include scanning electron microscopy, protein electrophoresis, atomic force microscopy, and tensile strength testing. Our study revealed evidence of proteoglycan network degradation, followed by the progressive disassembly of macroscopic collagen fibers into primary structural elements by catK. Proteolytically released GAGs are involved in the generation of collagenolytically active catK-GAG complexes as shown by AFM. In addition to their structural disintegration, a decrease in the tensile properties of fibers was observed due to the action of catK. The Young's moduli of untreated collagen fibers versus catK-treated fibers in dehydrated conditions were 3.2 ± 0.68 GPa and 1.9 ± 0.65 GPa, respectively. In contrast, cathepsin L, V, B, and S revealed no collagenase activity, except the disruption of proteoglycan-GAG interfibrillar bridges, which slightly decreased the tensile strength of fibers. PMID:23297404

Surveillance of diarrhoea in small animal practice through the Small Animal Veterinary Surveillance Network (SAVSNET).

PubMed

Jones, P H; Dawson, S; Gaskell, R M; Coyne, K P; Tierney, A; Setzkorn, C; Radford, A D; Noble, P-J M

2014-09-01

Using the Small Animal Veterinary Surveillance Network (SAVSNET), a national small animal disease-surveillance scheme, information on gastrointestinal disease was collected for a total of 76 days between 10 May 2010 and 8 August 2011 from 16,223 consultations (including data from 9115 individual dogs and 3462 individual cats) from 42 premises belonging to 19 UK veterinary practices. During that period, 7% of dogs and 3% of cats presented with diarrhoea. Adult dogs had a higher proportional morbidity of diarrhoea (PMD) than adult cats (P <0.001). This difference was not observed in animals <1 year old. Younger animals in both species had higher PMDs than adult animals (P < 0.001). Neutering was associated with reduced PMD in young male dogs. In adult dogs, miniature Schnauzers had the highest PMD. Most animals with diarrhoea (51%) presented having been ill for 2-4 days, but a history of vomiting or haemorrhagic diarrhoea was associated with a shorter time to presentation. The most common treatments employed were dietary modification (66% of dogs; 63% of cats) and antibacterials (63% of dogs; 49% of cats). There was variability in PMD between different practices. The SAVNET methodology facilitates rapid collection of cross-sectional data regarding diarrhoea, a recognised sentinel for infectious disease, and characterises data that could benchmark clinical practice and support the development of evidence-based medicine. Copyright © 2014 Elsevier Ltd. All rights reserved.

The Pilot Land Data System (PLDS) at the Ames Research Center manages aircraft data in collaboration with an ecosystem research project

NASA Technical Reports Server (NTRS)

Angelici, Gary; Popovici, Lidia; Skiles, Jay

1991-01-01

The Pilot Land Data System (PLDS) is a data and information system serving NASA-supported investigators in the land science community. The three nodes of the PLDS, one each at the Ames Research Center (ARC), the Goddard Space Flight Center (GSFC) and the Jet Propulsion Laboratory (JPL), cooperate in providing consistent information describing the various data holding in the hardware and software (accessible via network and modem) that provide information about and access to PLDS-held data, which is available for distribution. A major new activity of the PLDS node at the Ames Research Center involves the interaction of the PLDS with an active NASA ecosystem science project, the Oregon Transect Ecosystems Research involves the management of, access to, and distribution of the large volume of widely-varying aircraft data collected by OTTER. The OTTER project, is managed by researchers at the Ames Research Center and Oregon State University. Its principal objective is to estimate major fluxes of carbon, nitrogen, and water of forest ecosystems using an ecosystem process model driven by remote sensing data. Ten researchers at NASA centers and universities are analyzing data for six sites along a temperature-moisture gradient across the western half of central Oregon (called the Oregon Transect). Sensors mounted on six different aircraft have acquired data over the Oregon Transect in support of the OTTER project.

Design of Hybrid Mobile Communication Networks for Planetary Exploration

NASA Technical Reports Server (NTRS)

Alena, Richard L.; Ossenfort, John; Lee, Charles; Walker, Edward; Stone, Thom

2004-01-01

The Mobile Exploration System Project (MEX) at NASA Ames Research Center has been conducting studies into hybrid communication networks for future planetary missions. These networks consist of space-based communication assets connected to ground-based Internets and planetary surface-based mobile wireless networks. These hybrid mobile networks have been deployed in rugged field locations in the American desert and the Canadian arctic for support of science and simulation activities on at least six occasions. This work has been conducted over the past five years resulting in evolving architectural complexity, improved component characteristics and better analysis and test methods. A rich set of data and techniques have resulted from the development and field testing of the communication network during field expeditions such as the Haughton Mars Project and NASA Mobile Agents Project.

Intelligent detectors modelled from the cat's eye

NASA Astrophysics Data System (ADS)

Lindblad, Th.; Becanovic, V.; Lindsey, C. S.; Szekely, G.

1997-02-01

Biologically inspired image/signal processing, in particular neural networks like the Pulse-Coupled Neural Network (PCNN), are revisited. Their use with high granularity high-energy physics detectors, as well as optical sensing devices, for filtering, de-noising, segmentation, object isolation and edge detection is discussed.

Network protocols for real-time applications

NASA Technical Reports Server (NTRS)

Johnson, Marjory J.

1987-01-01

The Fiber Distributed Data Interface (FDDI) and the SAE AE-9B High Speed Ring Bus (HSRB) are emerging standards for high-performance token ring local area networks. FDDI was designed to be a general-purpose high-performance network. HSRB was designed specifically for military real-time applications. A workshop was conducted at NASA Ames Research Center in January, 1987 to compare and contrast these protocols with respect to their ability to support real-time applications. This report summarizes workshop presentations and includes an independent comparison of the two protocols. A conclusion reached at the workshop was that current protocols for the upper layers of the Open Systems Interconnection (OSI) network model are inadequate for real-time applications.

Signal propagation in cortical networks: a digital signal processing approach.

PubMed

Rodrigues, Francisco Aparecido; da Fontoura Costa, Luciano

2009-01-01

This work reports a digital signal processing approach to representing and modeling transmission and combination of signals in cortical networks. The signal dynamics is modeled in terms of diffusion, which allows the information processing undergone between any pair of nodes to be fully characterized in terms of a finite impulse response (FIR) filter. Diffusion without and with time decay are investigated. All filters underlying the cat and macaque cortical organization are found to be of low-pass nature, allowing the cortical signal processing to be summarized in terms of the respective cutoff frequencies (a high cutoff frequency meaning little alteration of signals through their intermixing). Several findings are reported and discussed, including the fact that the incorporation of temporal activity decay tends to provide more diversified cutoff frequencies. Different filtering intensity is observed for each community in those networks. In addition, the brain regions involved in object recognition tend to present the highest cutoff frequencies for both the cat and macaque networks.

Lumping of degree-based mean-field and pair-approximation equations for multistate contact processes

NASA Astrophysics Data System (ADS)

Kyriakopoulos, Charalampos; Grossmann, Gerrit; Wolf, Verena; Bortolussi, Luca

2018-01-01

Contact processes form a large and highly interesting class of dynamic processes on networks, including epidemic and information-spreading networks. While devising stochastic models of such processes is relatively easy, analyzing them is very challenging from a computational point of view, particularly for large networks appearing in real applications. One strategy to reduce the complexity of their analysis is to rely on approximations, often in terms of a set of differential equations capturing the evolution of a random node, distinguishing nodes with different topological contexts (i.e., different degrees of different neighborhoods), such as degree-based mean-field (DBMF), approximate-master-equation (AME), or pair-approximation (PA) approaches. The number of differential equations so obtained is typically proportional to the maximum degree kmax of the network, which is much smaller than the size of the master equation of the underlying stochastic model, yet numerically solving these equations can still be problematic for large kmax. In this paper, we consider AME and PA, extended to cope with multiple local states, and we provide an aggregation procedure that clusters together nodes having similar degrees, treating those in the same cluster as indistinguishable, thus reducing the number of equations while preserving an accurate description of global observables of interest. We also provide an automatic way to build such equations and to identify a small number of degree clusters that give accurate results. The method is tested on several case studies, where it shows a high level of compression and a reduction of computational time of several orders of magnitude for large networks, with minimal loss in accuracy.

Aeronautical-Satellite-Assisted Process Being Developed for Information Exchange Through Network Technologies (Aero-SAPIENT)

NASA Technical Reports Server (NTRS)

Zernic, Michael J.

2001-01-01

Communications technologies are being developed to address safety issues during aviation travel. Some of these technologies enable the aircraft to be in constant bidirectional communications with necessary systems, people, and other aircraft that are not currently in place today. Networking technologies, wireless datalinks, and advanced avionics techniques are areas of particular importance that the NASA Glenn Research Center has contributed. Glenn, in conjunction with the NASA Ames Research Center, NASA Dryden Flight Research Center, and NASA Langley Research Center, is investigating methods and applications that would utilize these communications technologies. In mid-June 2000, the flight readiness of the network and communications technologies were demonstrated via a simulated aircraft. A van simulating an aircraft was equipped with advanced phased-array antennas (Advanced Communications/Air Traffic Management (AC/ATM) Advanced Air Transportation Technologies (AATT) project) that used commercial Ku-band satellite communications to connect Glenn, Dryden, and Ames in a combined system ground test. This test simulated air-ground bidirectional transport of real-time digital audio, text, and video data via a hybrid network configuration that demonstrated the flight readiness of the network and communications technologies. Specifically, a Controller Pilot Data Link Communications application was used with other applications to demonstrate a multiprotocol capability via Internet-protocol encapsulated ATN (Aeronautical Telecommunications Network) data packets. The significance of this combined ground test is its contribution to the Aero Information Technology Base Program Level I milestone (Software Technology investment area) of a real-time data link for the National Airspace System. The objective of this milestone was to address multiprotocol technology applicable for real-time data links between aircraft, a satellite, and the ground as well as the ability to distribute flight data with multilevel priorities among several sites.

Stochastic surface walking reaction sampling for resolving heterogeneous catalytic reaction network: A revisit to the mechanism of water-gas shift reaction on Cu

NASA Astrophysics Data System (ADS)

Zhang, Xiao-Jie; Shang, Cheng; Liu, Zhi-Pan

2017-10-01

Heterogeneous catalytic reactions on surface and interfaces are renowned for ample intermediate adsorbates and complex reaction networks. The common practice to reveal the reaction mechanism is via theoretical computation, which locates all likely transition states based on the pre-guessed reaction mechanism. Here we develop a new theoretical method, namely, stochastic surface walking (SSW)-Cat method, to resolve the lowest energy reaction pathway of heterogeneous catalytic reactions, which combines our recently developed SSW global structure optimization and SSW reaction sampling. The SSW-Cat is automated and massively parallel, taking a rough reaction pattern as input to guide reaction search. We present the detailed algorithm, discuss the key features, and demonstrate the efficiency in a model catalytic reaction, water-gas shift reaction on Cu(111) (CO + H2O → CO2 + H2). The SSW-Cat simulation shows that water dissociation is the rate-determining step and formic acid (HCOOH) is the kinetically favorable product, instead of the observed final products, CO2 and H2. It implies that CO2 and H2 are secondary products from further decomposition of HCOOH at high temperatures. Being a general purpose tool for reaction prediction, the SSW-Cat may be utilized for rational catalyst design via large-scale computations.

Using high-performance networks to enable computational aerosciences applications

NASA Technical Reports Server (NTRS)

Johnson, Marjory J.

1992-01-01

One component of the U.S. Federal High Performance Computing and Communications Program (HPCCP) is the establishment of a gigabit network to provide a communications infrastructure for researchers across the nation. This gigabit network will provide new services and capabilities, in addition to increased bandwidth, to enable future applications. An understanding of these applications is necessary to guide the development of the gigabit network and other high-performance networks of the future. In this paper we focus on computational aerosciences applications run remotely using the Numerical Aerodynamic Simulation (NAS) facility located at NASA Ames Research Center. We characterize these applications in terms of network-related parameters and relate user experiences that reveal limitations imposed by the current wide-area networking infrastructure. Then we investigate how the development of a nationwide gigabit network would enable users of the NAS facility to work in new, more productive ways.

Queuing theory models for computer networks

NASA Technical Reports Server (NTRS)

Galant, David C.

1989-01-01

A set of simple queuing theory models which can model the average response of a network of computers to a given traffic load has been implemented using a spreadsheet. The impact of variations in traffic patterns and intensities, channel capacities, and message protocols can be assessed using them because of the lack of fine detail in the network traffic rates, traffic patterns, and the hardware used to implement the networks. A sample use of the models applied to a realistic problem is included in appendix A. Appendix B provides a glossary of terms used in this paper. This Ames Research Center computer communication network is an evolving network of local area networks (LANs) connected via gateways and high-speed backbone communication channels. Intelligent planning of expansion and improvement requires understanding the behavior of the individual LANs as well as the collection of networks as a whole.

Identification and classification of hubs in brain networks.

PubMed

Sporns, Olaf; Honey, Christopher J; Kötter, Rolf

2007-10-17

Brain regions in the mammalian cerebral cortex are linked by a complex network of fiber bundles. These inter-regional networks have previously been analyzed in terms of their node degree, structural motif, path length and clustering coefficient distributions. In this paper we focus on the identification and classification of hub regions, which are thought to play pivotal roles in the coordination of information flow. We identify hubs and characterize their network contributions by examining motif fingerprints and centrality indices for all regions within the cerebral cortices of both the cat and the macaque. Motif fingerprints capture the statistics of local connection patterns, while measures of centrality identify regions that lie on many of the shortest paths between parts of the network. Within both cat and macaque networks, we find that a combination of degree, motif participation, betweenness centrality and closeness centrality allows for reliable identification of hub regions, many of which have previously been functionally classified as polysensory or multimodal. We then classify hubs as either provincial (intra-cluster) hubs or connector (inter-cluster) hubs, and proceed to show that lesioning hubs of each type from the network produces opposite effects on the small-world index. Our study presents an approach to the identification and classification of putative hub regions in brain networks on the basis of multiple network attributes and charts potential links between the structural embedding of such regions and their functional roles.

Aviation Simulators for the Desktop: Panel and Demonstrations

NASA Technical Reports Server (NTRS)

Pisanich, Greg; Rosekind, Marl R. (Technical Monitor)

1997-01-01

Panel Members are: Christine M. Mitchell (Georgia Tech), Michael T. Palmer (NASA Langley), Greg Pisani (NASA Ames), and Amy R. Pritchett (MIT). The Panel members are affiliated with aviation human factors groups from NASA Ames, NASA Langley, MITCHELL Department of Aerospace and Aeronautical Engineering, and Georgia Technics Center for Human-Machine Systems Research. Panelists will describe the simulator(s) used in their respective institutions including a description of the FMS aircraft models, software, hardware, and displays. Panelists will summarize previous, on-going, and planned empirical studies conducted with the simulators. Greg Pisanich will describe two NASA Ames simulation systems: the Stone Soup Simulator (SSS), and the Airspace Operations Human Factors Simulation Laboratory. The the Stone Soup Simulator is a desktop-based, research flight simulator that includes mode control, flight management, and datalink functionality. It has been developed as a non-proprietary simulator that can be easily distributed to academic and industry researchers who are collaborating on NASA research projects. It will be used and extended by research groups represented by at least two panelists (Mitchell and Palmer). The Airspace Operations Simulator supports the study of air traffic control in conjunction with the flight deck. This simulator will be used provide an environment in which many AATT and free flight concepts can be demonstrated and evaluated. Mike Palmer will describe two NASA Langley efforts: The Langley Simulator and MD-11 extensions to the NASA Amesbury simulator. The first simulator is publicly available and combines a B-737 model with a high fidelity flight management system. The second simulator enhances the S3 simulator with MD-11 electronic flight displays together with modifications to the flight and FMS models to emulate MD-11 dynamics and operations. Chris Mitchell will describe GT-EFIRT (Georgia Tech-Electronic Flight Instrument Research Tool) and B-757 enhancements to the NASA Ames S3. GT-EFIRT is a medium fidelity simulator used to conduct preliminary studies of the CATS (crew activity tracking system). Like the Langley efforts with S3, the Georgia Tech enhancements will allow it to emulate the dynamics and operations of a widely used glass cockpit. Amy Pritchett will describe the MIT simulator(s) that have been used in a range of research investigating cockpit displays, warning devices, and flight deck-ATC interaction.

Control Software

NASA Technical Reports Server (NTRS)

1997-01-01

Real-Time Innovations, Inc. (RTI) collaborated with Ames Research Center, the Jet Propulsion Laboratory and Stanford University to leverage NASA research to produce ControlShell software. RTI is the first "graduate" of Ames Research Center's Technology Commercialization Center. The ControlShell system was used extensively on a cooperative project to enhance the capabilities of a Russian-built Marsokhod rover being evaluated for eventual flight to Mars. RTI's ControlShell is complex, real-time command and control software, capable of processing information and controlling mechanical devices. One ControlShell tool is StethoScope. As a real-time data collection and display tool, StethoScope allows a user to see how a program is running without changing its execution. RTI has successfully applied its software savvy in other arenas, such as telecommunications, networking, video editing, semiconductor manufacturing, automobile systems, and medical imaging.

An automated calibration laboratory for flight research instrumentation: Requirements and a proposed design approach

NASA Technical Reports Server (NTRS)

Oneill-Rood, Nora; Glover, Richard D.

1990-01-01

NASA's Dryden Flight Research Facility (Ames-Dryden), operates a diverse fleet of research aircraft which are heavily instrumented to provide both real time data for in-flight monitoring and recorded data for postflight analysis. Ames-Dryden's existing automated calibration (AUTOCAL) laboratory is a computerized facility which tests aircraft sensors to certify accuracy for anticipated harsh flight environments. Recently, a major AUTOCAL lab upgrade was initiated; the goal of this modernization is to enhance productivity and improve configuration management for both software and test data. The new system will have multiple testing stations employing distributed processing linked by a local area network to a centralized database. The baseline requirements for the new AUTOCAL lab and the design approach being taken for its mechanization are described.

Team Modelling: Survey of Experimental Platforms (Modelisation d’equipes : Examen de plate-formes experimentales)

DTIC Science & Technology

2006-09-01

Control Force Agility Shared Situational Awareness Attentional Demand Interoperability Network Based Operations Effect Based Operations Speed of...Command Self Synchronization Reach Back Reach Forward Information Superiority Increased Mission Effectiveness Humansystems® Team Modelling...communication effectiveness and Distributed Mission Training (DMT) effectiveness . The NASA Ames Centre - Distributed Research Facilities platform could

A mass storage system for supercomputers based on Unix

NASA Technical Reports Server (NTRS)

Richards, J.; Kummell, T.; Zarlengo, D. G.

1988-01-01

The authors present the design, implementation, and utilization of a large mass storage subsystem (MSS) for the numerical aerodynamics simulation. The MSS supports a large networked, multivendor Unix-based supercomputing facility. The MSS at Ames Research Center provides all processors on the numerical aerodynamics system processing network, from workstations to supercomputers, the ability to store large amounts of data in a highly accessible, long-term repository. The MSS uses Unix System V and is capable of storing hundreds of thousands of files ranging from a few bytes to 2 Gb in size.

RIACS FY2002 Annual Report

NASA Technical Reports Server (NTRS)

Leiner, Barry M.; Gross, Anthony R. (Technical Monitor)

2002-01-01

The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. Operated by the Universities Space Research Association (a non-profit university consortium), RIACS is located at the NASA Ames Research Center, Moffett Field, California. It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in September 2003. Ames has been designated NASA's Center of Excellence in Information Technology. In this capacity, Ames is charged with the responsibility to build an Information Technology (IT) Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA Ames and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of IT research necessary to meet the future challenges of NASA missions: 1) Automated Reasoning for Autonomous Systems; 2) Human-Centered Computing; and 3) High Performance Computing and Networking. In addition, RIACS collaborates with NASA scientists to apply IT research to a variety of NASA application domains including aerospace technology, earth science, life sciences, and astrobiology. RIACS also engages in other activities, such as workshops, seminars, visiting scientist programs and student summer programs, designed to encourage and facilitate collaboration between the university and NASA IT research communities.

Lumping of degree-based mean-field and pair-approximation equations for multistate contact processes.

PubMed

Kyriakopoulos, Charalampos; Grossmann, Gerrit; Wolf, Verena; Bortolussi, Luca

2018-01-01

Contact processes form a large and highly interesting class of dynamic processes on networks, including epidemic and information-spreading networks. While devising stochastic models of such processes is relatively easy, analyzing them is very challenging from a computational point of view, particularly for large networks appearing in real applications. One strategy to reduce the complexity of their analysis is to rely on approximations, often in terms of a set of differential equations capturing the evolution of a random node, distinguishing nodes with different topological contexts (i.e., different degrees of different neighborhoods), such as degree-based mean-field (DBMF), approximate-master-equation (AME), or pair-approximation (PA) approaches. The number of differential equations so obtained is typically proportional to the maximum degree k_{max} of the network, which is much smaller than the size of the master equation of the underlying stochastic model, yet numerically solving these equations can still be problematic for large k_{max}. In this paper, we consider AME and PA, extended to cope with multiple local states, and we provide an aggregation procedure that clusters together nodes having similar degrees, treating those in the same cluster as indistinguishable, thus reducing the number of equations while preserving an accurate description of global observables of interest. We also provide an automatic way to build such equations and to identify a small number of degree clusters that give accurate results. The method is tested on several case studies, where it shows a high level of compression and a reduction of computational time of several orders of magnitude for large networks, with minimal loss in accuracy.

Evolutionary Ensemble for In Silico Prediction of Ames Test Mutagenicity

NASA Astrophysics Data System (ADS)

Chen, Huanhuan; Yao, Xin

Driven by new regulations and animal welfare, the need to develop in silico models has increased recently as alternative approaches to safety assessment of chemicals without animal testing. This paper describes a novel machine learning ensemble approach to building an in silico model for the prediction of the Ames test mutagenicity, one of a battery of the most commonly used experimental in vitro and in vivo genotoxicity tests for safety evaluation of chemicals. Evolutionary random neural ensemble with negative correlation learning (ERNE) [1] was developed based on neural networks and evolutionary algorithms. ERNE combines the method of bootstrap sampling on training data with the method of random subspace feature selection to ensure diversity in creating individuals within an initial ensemble. Furthermore, while evolving individuals within the ensemble, it makes use of the negative correlation learning, enabling individual NNs to be trained as accurate as possible while still manage to maintain them as diverse as possible. Therefore, the resulting individuals in the final ensemble are capable of cooperating collectively to achieve better generalization of prediction. The empirical experiment suggest that ERNE is an effective ensemble approach for predicting the Ames test mutagenicity of chemicals.

Interactions between neurons in the frontal cortex and hippocampus in cats trained to select reinforcements of different value in conditions of cholinergic deficiency.

PubMed

Dolbakyan, E E; Merzhanova, G Kh

2007-09-01

An operant food-related conditioned reflex was developed in six cats by the "active choice" protocol: short-latency pedal presses were followed by presentation of low-quality reinforcement (bread-meat mix), while long-latency pedal presses were followed by presentation of high-quality reinforcement (meat). Animals differed in terms of their food-procuring strategies, displaying "self-control," "ambivalence," or "impulsivity." Multineuron activity was recorded from the frontal cortex and hippocampus (field CA3). Cross-correlation analysis of interneuronal interactions within (local networks) and between (distributed networks) study structures showed that the numbers of interneuronal interactions in both local and distributed networks were maximal in animals with "self-control." On the background of systemic administration of the muscarinic cholinoreceptor blockers scopolamine and trihexyphenidyl, the numbers of interneuronal interactions decreased, while "common source" influences increased. This correlated with impairment of the reproduction of the selected strategy, primarily affecting the animals' self-controlled behavior. These results show that the "self-control" strategy is determined by the organization of local and distributed networks in the frontal cortex and hippocampus.

Networks for image acquisition, processing and display

NASA Technical Reports Server (NTRS)

Ahumada, Albert J., Jr.

1990-01-01

The human visual system comprises layers of networks which sample, process, and code images. Understanding these networks is a valuable means of understanding human vision and of designing autonomous vision systems based on network processing. Ames Research Center has an ongoing program to develop computational models of such networks. The models predict human performance in detection of targets and in discrimination of displayed information. In addition, the models are artificial vision systems sharing properties with biological vision that has been tuned by evolution for high performance. Properties include variable density sampling, noise immunity, multi-resolution coding, and fault-tolerance. The research stresses analysis of noise in visual networks, including sampling, photon, and processing unit noises. Specific accomplishments include: models of sampling array growth with variable density and irregularity comparable to that of the retinal cone mosaic; noise models of networks with signal-dependent and independent noise; models of network connection development for preserving spatial registration and interpolation; multi-resolution encoding models based on hexagonal arrays (HOP transform); and mathematical procedures for simplifying analysis of large networks.

Validation of PROMIS ® Physical Function computerized adaptive tests for orthopaedic foot and ankle outcome research.

PubMed

Hung, Man; Baumhauer, Judith F; Latt, L Daniel; Saltzman, Charles L; SooHoo, Nelson F; Hunt, Kenneth J

2013-11-01

In 2012, the American Orthopaedic Foot & Ankle Society(®) established a national network for collecting and sharing data on treatment outcomes and improving patient care. One of the network's initiatives is to explore the use of computerized adaptive tests (CATs) for patient-level outcome reporting. We determined whether the CAT from the NIH Patient Reported Outcome Measurement Information System(®) (PROMIS(®)) Physical Function (PF) item bank provides efficient, reliable, valid, precise, and adequately covered point estimates of patients' physical function. After informed consent, 288 patients with a mean age of 51 years (range, 18-81 years) undergoing surgery for common foot and ankle problems completed a web-based questionnaire. Efficiency was determined by time for test administration. Reliability was assessed with person and item reliability estimates. Validity evaluation included content validity from expert review and construct validity measured against the PROMIS(®) Pain CAT and patient responses based on tradeoff perceptions. Precision was assessed by standard error of measurement (SEM) across patients' physical function levels. Instrument coverage was based on a person-item map. Average time of test administration was 47 seconds. Reliability was 0.96 for person and 0.99 for item. Construct validity against the Pain CAT had an r value of -0.657 (p < 0.001). Precision had an SEM of less than 3.3 (equivalent to a Cronbach's alpha of ≥ 0.90) across a broad range of function. Concerning coverage, the ceiling effect was 0.32% and there was no floor effect. The PROMIS(®) PF CAT appears to be an excellent method for measuring outcomes for patients with foot and ankle surgery. Further validation of the PROMIS(®) item banks may ultimately provide a valid and reliable tool for measuring patient-reported outcomes after injuries and treatment.

U.S. Tank Platoon Training for the 1987 Canadian Army Trophy (CAT) competition Using a Simulation Networking (SIMNET) System

DTIC Science & Technology

1987-10-01

will be addressed as the Testbed is constructed: 0. (1) How can a large cluster of simulators be networked at a singie " site ? [For example, a battalion... network and its subject LAN sites networked with Lt-N technology. *-" m-artter were based umDn technical and military There will be 324 simulators in all...If all sites "Cori consicerations. were active at one time, 1,400 troops would be involved- The technical assessment was that a local area network

Alcohol mixed with energy drink (AMED): A critical review and meta‐analysis

PubMed Central

Benson, Sarah; Johnson, Sean J.; Alford, Chris; Godefroy, Samuel Benrejeb; Scholey, Andrew

2018-01-01

Abstract The purpose of this systematic review and meta‐analysis was to critically review the (1) prevalence of alcohol mixed with energy drink (AMED) consumption, (2) motives for AMED consumption, (3) correlates of AMED consumption, and (4) whether AMED consumption has an impact on (a) alcohol consumption, (b) subjective intoxication, and (c) risk‐taking behavior. Overall a minority of the population consumes AMED, typically infrequently. Motives for AMED consumption are predominantly hedonistic and social. Meta‐analyses revealed that AMED consumers drink significantly more alcohol than alcohol‐only (AO) consumers. Within‐subject comparisons restricted to AMED consumers revealed that alcohol consumption does not significantly differ between typical AMED and AO occasions. On past month heaviest drinking occasions, AMED users consume significantly less alcohol on AMED occasions when compared to AO occasions. AMED consumers experience significantly fewer negative consequences and risk‐taking behavior on AMED occasions compared with AO occasions. Meta‐analyses of subjective intoxication studies suggest that AMED consumption does not differentially affect subjective intoxication when compared to AO consumption. In conclusion, when compared to AO consumption, mixing alcohol with energy drink does not affect subjective intoxication and seems unlikely to increase total alcohol consumption, associated risk‐taking behavior, nor other negative alcohol‐related consequences. Further research may be necessary to fully reveal the effects of AMED. PMID:29417616

Fault Tolerance in ZigBee Wireless Sensor Networks

NASA Technical Reports Server (NTRS)

Alena, Richard; Gilstrap, Ray; Baldwin, Jarren; Stone, Thom; Wilson, Pete

2011-01-01

Wireless sensor networks (WSN) based on the IEEE 802.15.4 Personal Area Network standard are finding increasing use in the home automation and emerging smart energy markets. The network and application layers, based on the ZigBee 2007 PRO Standard, provide a convenient framework for component-based software that supports customer solutions from multiple vendors. This technology is supported by System-on-a-Chip solutions, resulting in extremely small and low-power nodes. The Wireless Connections in Space Project addresses the aerospace flight domain for both flight-critical and non-critical avionics. WSNs provide the inherent fault tolerance required for aerospace applications utilizing such technology. The team from Ames Research Center has developed techniques for assessing the fault tolerance of ZigBee WSNs challenged by radio frequency (RF) interference or WSN node failure.

Multi-crop area estimation and mapping on a microprocessor/mainframe network

NASA Technical Reports Server (NTRS)

Sheffner, E.

1985-01-01

The data processing system is outlined for a 1985 test aimed at determining the performance characteristics of area estimation and mapping procedures connected with the California Cooperative Remote Sensing Project. The project is a joint effort of the USDA Statistical Reporting Service-Remote Sensing Branch, the California Department of Water Resources, NASA-Ames Research Center, and the University of California Remote Sensing Research Program. One objective of the program was to study performance when data processing is done on a microprocessor/mainframe network under operational conditions. The 1985 test covered the hardware, software, and network specifications and the integration of these three components. Plans for the year - including planned completion of PEDITOR software, testing of software on MIDAS, and accomplishment of data processing on the MIDAS-VAX-CRAY network - are discussed briefly.

Alcohol mixed with energy drink (AMED): A critical review and meta-analysis.

PubMed

Verster, Joris C; Benson, Sarah; Johnson, Sean J; Alford, Chris; Godefroy, Samuel Benrejeb; Scholey, Andrew

2018-03-01

The purpose of this systematic review and meta-analysis was to critically review the (1) prevalence of alcohol mixed with energy drink (AMED) consumption, (2) motives for AMED consumption, (3) correlates of AMED consumption, and (4) whether AMED consumption has an impact on (a) alcohol consumption, (b) subjective intoxication, and (c) risk-taking behavior. Overall a minority of the population consumes AMED, typically infrequently. Motives for AMED consumption are predominantly hedonistic and social. Meta-analyses revealed that AMED consumers drink significantly more alcohol than alcohol-only (AO) consumers. Within-subject comparisons restricted to AMED consumers revealed that alcohol consumption does not significantly differ between typical AMED and AO occasions. On past month heaviest drinking occasions, AMED users consume significantly less alcohol on AMED occasions when compared to AO occasions. AMED consumers experience significantly fewer negative consequences and risk-taking behavior on AMED occasions compared with AO occasions. Meta-analyses of subjective intoxication studies suggest that AMED consumption does not differentially affect subjective intoxication when compared to AO consumption. In conclusion, when compared to AO consumption, mixing alcohol with energy drink does not affect subjective intoxication and seems unlikely to increase total alcohol consumption, associated risk-taking behavior, nor other negative alcohol-related consequences. Further research may be necessary to fully reveal the effects of AMED. © 2018 The Authors Human Psychopharmacology: Clinical and Experimental Published by John Wiley & Sons Ltd.

Feature combination networks for the interpretation of statistical machine learning models: application to Ames mutagenicity.

PubMed

Webb, Samuel J; Hanser, Thierry; Howlin, Brendan; Krause, Paul; Vessey, Jonathan D

2014-03-25

A new algorithm has been developed to enable the interpretation of black box models. The developed algorithm is agnostic to learning algorithm and open to all structural based descriptors such as fragments, keys and hashed fingerprints. The algorithm has provided meaningful interpretation of Ames mutagenicity predictions from both random forest and support vector machine models built on a variety of structural fingerprints.A fragmentation algorithm is utilised to investigate the model's behaviour on specific substructures present in the query. An output is formulated summarising causes of activation and deactivation. The algorithm is able to identify multiple causes of activation or deactivation in addition to identifying localised deactivations where the prediction for the query is active overall. No loss in performance is seen as there is no change in the prediction; the interpretation is produced directly on the model's behaviour for the specific query. Models have been built using multiple learning algorithms including support vector machine and random forest. The models were built on public Ames mutagenicity data and a variety of fingerprint descriptors were used. These models produced a good performance in both internal and external validation with accuracies around 82%. The models were used to evaluate the interpretation algorithm. Interpretation was revealed that links closely with understood mechanisms for Ames mutagenicity. This methodology allows for a greater utilisation of the predictions made by black box models and can expedite further study based on the output for a (quantitative) structure activity model. Additionally the algorithm could be utilised for chemical dataset investigation and knowledge extraction/human SAR development.

Photographer: NASA Ames On 20 December 1989, Ames buried a time capsule and unveiled a sculpture at

NASA Technical Reports Server (NTRS)

1989-01-01

Photographer: NASA Ames On 20 December 1989, Ames buried a time capsule and unveiled a sculpture at the spot where, fifty years earlier, Russel Robinson had turned the first spade of dirt for the Ames construction shack: Robinson (left) Ames Director Dale Compton (center) and Ames Deputy Director Sy Syvertson (right)

Integrated Fatigue Damage Diagnosis and Prognosis Under Uncertainties

DTIC Science & Technology

2012-09-01

Integrated fatigue damage diagnosis and prognosis under uncertainties Tishun Peng 1 , Jingjing He 1 , Yongming Liu 1 , Abhinav Saxena 2 , Jose...Ames Research Center, Moffett Field, CA, 94035, USA kai.goebel@nasa.gov ABSTRACT An integrated fatigue damage diagnosis and prognosis framework is...remaining useful life (RUL) prediction. First, a piezoelectric sensor network is used to detect the fatigue crack size near the rivet holes in fuselage

High performance computing for advanced modeling and simulation of materials

NASA Astrophysics Data System (ADS)

Wang, Jue; Gao, Fei; Vazquez-Poletti, Jose Luis; Li, Jianjiang

2017-02-01

The First International Workshop on High Performance Computing for Advanced Modeling and Simulation of Materials (HPCMS2015) was held in Austin, Texas, USA, Nov. 18, 2015. HPCMS 2015 was organized by Computer Network Information Center (Chinese Academy of Sciences), University of Michigan, Universidad Complutense de Madrid, University of Science and Technology Beijing, Pittsburgh Supercomputing Center, China Institute of Atomic Energy, and Ames Laboratory.

Experimental investigation into infrasonic emissions from atmospheric turbulence.

PubMed

Shams, Qamar A; Zuckerwar, Allan J; Burkett, Cecil G; Weistroffer, George R; Hugo, Derek R

2013-03-01

Clear air turbulence (CAT) is the leading cause of in-flight injuries and in severe cases can result in fatalities. The purpose of this work is to design and develop an infrasonic array network for early warning of clear air turbulence. The infrasonic system consists of an infrasonic three-microphone array, compact windscreens, and data management system. Past experimental efforts to detect acoustic emissions from CAT have been limited. An array of three infrasonic microphones, operating in the field at NASA Langley Research Center, on several occasions received signals interpreted as infrasonic emissions from CAT. Following comparison with current lidar and other past methods, the principle of operation, the experimental methods, and experimental data are presented for case studies and confirmed by pilot reports. The power spectral density of the received signals was found to fit a power law having an exponent of -6 to -7, which is found to be characteristics of infrasonic emissions from CAT, in contrast to findings of the past.

Scientific Visualization in High Speed Network Environments

NASA Technical Reports Server (NTRS)

Vaziri, Arsi; Kutler, Paul (Technical Monitor)

1997-01-01

In several cases, new visualization techniques have vastly increased the researcher's ability to analyze and comprehend data. Similarly, the role of networks in providing an efficient supercomputing environment have become more critical and continue to grow at a faster rate than the increase in the processing capabilities of supercomputers. A close relationship between scientific visualization and high-speed networks in providing an important link to support efficient supercomputing is identified. The two technologies are driven by the increasing complexities and volume of supercomputer data. The interaction of scientific visualization and high-speed networks in a Computational Fluid Dynamics simulation/visualization environment are given. Current capabilities supported by high speed networks, supercomputers, and high-performance graphics workstations at the Numerical Aerodynamic Simulation Facility (NAS) at NASA Ames Research Center are described. Applied research in providing a supercomputer visualization environment to support future computational requirements are summarized.

Experiences with the AEROnet/PSCN ATM Prototype

NASA Technical Reports Server (NTRS)

Kurak, Richard S.; Lisotta, Anthony J.; McCabe, James D.; Nothaft, Alfred E.; Russell, Kelly R.; Lasinski, T. A. (Technical Monitor)

1995-01-01

This paper discusses the experience gained by the AEROnet/PSCN networking team in deploying a prototype Asynchronous Transfer Mode (ATM) based network as part of the wide-area network for the Numerical Aerodynamic Simulation (NAS) Program at NASA Ames Research Center. The objectives of this prototype were to test concepts in using ATM over wide-area Internet Protocol (IP) networks and measure end-to-end system performance. This testbed showed that end-to-end ATM over a DS3 reaches approximately 80% of the throughput achieved from a FDDI to DS3 network. The 20% reduction in through-put can be attributed to the overhead associated with running ATM. As a result, we conclude that if the loss in capacity due to ATM overhead is balanced by the reduction in cost of ATM services, as compared to dedicated circuits, then ATM can be a viable alternative.

Improving Situational Awareness for First Responders via Mobile Computing

NASA Technical Reports Server (NTRS)

Betts, Bradley J.; Mah, Robert W.; Papasin, Richard; Del Mundo, Rommel; McIntosh, Dawn M.; Jorgensen, Charles

2005-01-01

This project looks to improve first responder situational awareness using tools and techniques of mobile computing. The prototype system combines wireless communication, real-time location determination, digital imaging, and three-dimensional graphics. Responder locations are tracked in an outdoor environment via GPS and uploaded to a central server via GPRS or an 802.11 network. Responders can also wirelessly share digital images and text reports, both with other responders and with the incident commander. A pre-built three dimensional graphics model of a particular emergency scene is used to visualize responder and report locations. Responders have a choice of information end points, ranging from programmable cellular phones to tablet computers. The system also employs location-aware computing to make responders aware of particular hazards as they approach them. The prototype was developed in conjunction with the NASA Ames Disaster Assistance and Rescue Team and has undergone field testing during responder exercise at NASA Ames.

Improving Situational Awareness for First Responders via Mobile Computing

NASA Technical Reports Server (NTRS)

Betts, Bradley J.; Mah, Robert W.; Papasin, Richard; Del Mundo, Rommel; McIntosh, Dawn M.; Jorgensen, Charles

2006-01-01

This project looks to improve first responder incident command, and an appropriately managed flow of situational awareness using mobile computing techniques. The prototype system combines wireless communication, real-time location determination, digital imaging, and three-dimensional graphics. Responder locations are tracked in an outdoor environment via GPS and uploaded to a central server via GPRS or an 802. II network. Responders can also wireless share digital images and text reports, both with other responders and with the incident commander. A pre-built three dimensional graphics model of the emergency scene is used to visualize responder and report locations. Responders have a choice of information end points, ranging from programmable cellular phones to tablet computers. The system also employs location-aware computing to make responders aware of particular hazards as they approach them. The prototype was developed in conjunction with the NASA Ames Disaster Assistance and Rescue Team and has undergone field testing during responder exercises at NASA Ames.

Using Neural Net Technology To Enhance the Efficiency of a Computer Adaptive Testing Application.

ERIC Educational Resources Information Center

Van Nelson, C.; Henriksen, Larry W.

The potential for computer adaptive testing (CAT) has been well documented. In order to improve the efficiency of this process, it may be possible to utilize a neural network, or more specifically, a back propagation neural network. The paper asserts that in order to accomplish this end, it must be shown that grouping examinees by ability as…

Contrast radiographic study of venous drainage of the corpus cavernosum and the corpus spongiosum of the cat penis.

PubMed

Amiri, Ali Akbar; Gilanpour, Hassan; Veshkini, Abbas

2014-01-01

The aim of this study was to determine the drainage routes of the corpus cvernosum penis and the corpus spongiosum penis in the cat using contrast cavernosography. Five male cats, 1.5-2.5 years old, weighing between 4.5 and 5.5 kg were investigated. The cats were anesthetized and the root and the proximal part of the penis were exposed by an incision on the perineum reaching the scrotum. Each cat was radiographed in lateral and dorsal recumbency before and during injection of contrast medium into the erectile bodies. The corpus spongiosum penis was injected at the bulb of the penis and the corpus cavernosum penis at the root. Injection of contrast media into the cavernous bodies showed that both the external and internal iliac veins drain the erectile bodies into the caudal vena cava. Drainage from the corpus spongiosum penis was from the bulb for the proximal part and from the glans for the distal part. The corpus cavernosum penis was drained only proximally, from the crura. There was a network of veins above the pelvic symphysis and the drainage of erectile bodies where through various routes into the internal and external iliac veins.

Toward Real Time Neural Net Flight Controllers

NASA Technical Reports Server (NTRS)

Jorgensen, C. C.; Mah, R. W.; Ross, J.; Lu, Henry, Jr. (Technical Monitor)

1994-01-01

NASA Ames Research Center has an ongoing program in neural network control technology targeted toward real time flight demonstrations using a modified F-15 which permits direct inner loop control of actuators, rapid switching between alternative control designs, and substitutable processors. An important part of this program is the ACTIVE flight project which is examining the feasibility of using neural networks in the design, control, and system identification of new aircraft prototypes. This paper discusses two research applications initiated with this objective in mind: utilization of neural networks for wind tunnel aircraft model identification and rapid learning algorithms for on line reconfiguration and control. The first application involves the identification of aerodynamic flight characteristics from analysis of wind tunnel test data. This identification is important in the early stages of aircraft design because complete specification of control architecture's may not be possible even though concept models at varying scales are available for aerodynamic wind tunnel testing. Testing of this type is often a long and expensive process involving measurement of aircraft lift, drag, and moment of inertia at varying angles of attack and control surface configurations. This information in turn can be used in the design of the flight control systems by applying the derived lookup tables to generate piece wise linearized controllers. Thus, reduced costs in tunnel test times and the rapid transfer of wind tunnel insights into prototype controllers becomes an important factor in more efficient generation and testing of new flight systems. NASA Ames Research Center is successfully applying modular neural networks as one way of anticipating small scale aircraft model performances prior to testing, thus reducing the number of in tunnel test hours and potentially, the number of intermediate scaled models required for estimation of surface flow effects.

Microbiology and potential applications of aerobic methane oxidation coupled to denitrification (AME-D) process: A review.

PubMed

Zhu, Jing; Wang, Qian; Yuan, Mengdong; Tan, Giin-Yu Amy; Sun, Faqian; Wang, Cheng; Wu, Weixiang; Lee, Po-Heng

2016-03-01

Aerobic methane oxidation coupled to denitrification (AME-D) is an important link between the global methane and nitrogen cycles. This mini-review updates discoveries regarding aerobic methanotrophs and denitrifiers, as a prelude to spotlight the microbial mechanism and the potential applications of AME-D. Until recently, AME-D was thought to be accomplished by a microbial consortium where denitrifying bacteria utilize carbon intermediates, which are excreted by aerobic methanotrophs, as energy and carbon sources. Potential carbon intermediates include methanol, citrate and acetate. This mini-review presents microbial thermodynamic estimations and postulates that methanol is the ideal electron donor for denitrification, and may serve as a trophic link between methanotrophic bacteria and denitrifiers. More excitingly, new discoveries have revealed that AME-D is not only confined to the conventional synergism between methanotrophic bacteria and denitrifiers. Specifically, an obligate aerobic methanotrophic bacterium, Methylomonas denitrificans FJG1, has been demonstrated to couple partial denitrification with methane oxidation, under hypoxia conditions, releasing nitrous oxide as a terminal product. This finding not only substantially advances the understanding of AME-D mechanism, but also implies an important but unknown role of aerobic methanotrophs in global climate change through their influence on both the methane and nitrogen cycles in ecosystems. Hence, further investigation on AME-D microbiology and mechanism is essential to better understand global climate issues and to develop niche biotechnological solutions. This mini-review also presents traditional microbial techniques, such as pure cultivation and stable isotope probing, and powerful microbial techniques, such as (meta-) genomics and (meta-) transcriptomics, for deciphering linked methane oxidation and denitrification. Although AME-D has immense potential for nitrogen removal from wastewater, drinking water and groundwater, bottlenecks and potential issues are also discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.

[Met]- and [Leu]enkephalin-like immunoreactive cell bodies and nerve fibres in the coeliac ganglion of the cat.

PubMed

Julé, Y; Clerc, N; Niel, J P; Condamin, M

1986-06-01

The occurrence and distribution of methionine- and leucine-enkephalin-like immunoreactivity were investigated in the cat coeliac ganglion using either the indirect immunoperoxidase method or the peroxidase-antiperoxidase technique. Several antisera raised to methionine- and leucine-enkephalin were used. Their specificity was assessed by incubating sections of the coeliac ganglion with increasing dilutions of antisera and with antisera saturated with their respective antigen. The present study was performed both in untreated and in colchicine-treated cats. Immunoreactive methionine- and leucine-enkephalin-like cell bodies were only visualized in colchicine-treated cats. Two types of labeled cells were observed. The first type had a size similar to that of unlabeled principal ganglion cells. These labeled cells were numerous and scattered throughout the ganglion; they probably represented enkephalin-containing ganglion cells. The second type of immunoreactive cells were of a much smaller size. They were always gathered in small clusters of about 5-15 cells and were not numerous; they presumably represented enkephalin-containing small intensely fluorescent cells. Immunoreactive nerve fibres were mainly observed in untreated cats and accessorily in colchicine-treated cats. In untreated animals dense networks of methionine- and leucine-enkephalin-like immunoreactive fibres were found in the coeliac ganglion. These fibres had numerous varicosities which often closely surrounded unlabeled principal ganglion cells. In colchicine-treated cats some immunoreactive fibres surrounded labeled principal ganglion cell bodies. The present results establish for the first time the presence of enkephalin-like immunoreactive principal ganglion cells in a mammalian sympathetic prevertebral ganglion. The presence of enkephalin-containing principal ganglion cells, small intensely fluorescent cells and nerve terminals, supports an important role of enkephalins in the integrative synaptic activities of cat coeliac ganglion cells.

Micro Cathode Arc Thruster for PhoneSat: Development and Potential Applications

NASA Technical Reports Server (NTRS)

Gazulla, Oriol Tintore; Perez, Andres Dono; Agasid, Elwood; Uribe, Eddie; Trinh, Greenfield; Keidar, Michael; Teel, George; Haque, Samudra; Lukas, Joseph; Salas, Alberto Guillen;

Particle simulation on heterogeneous distributed supercomputers

NASA Technical Reports Server (NTRS)

Becker, Jeffrey C.; Dagum, Leonardo

1993-01-01

We describe the implementation and performance of a three dimensional particle simulation distributed between a Thinking Machines CM-2 and a Cray Y-MP. These are connected by a combination of two high-speed networks: a high-performance parallel interface (HIPPI) and an optical network (UltraNet). This is the first application to use this configuration at NASA Ames Research Center. We describe our experience implementing and using the application and report the results of several timing measurements. We show that the distribution of applications across disparate supercomputing platforms is feasible and has reasonable performance. In addition, several practical aspects of the computing environment are discussed.

Modular Pulsed Plasma Electric Propulsion System for Cubesats

NASA Technical Reports Server (NTRS)

Perez, Andres Dono; Gazulla, Oriol Tintore; Teel, George Lewis; Mai, Nghia; Lukas, Joseph; Haque, Sumadra; Uribe, Eddie; Keidar, Michael; Agasid, Elwood

2014-01-01

Current capabilities of CubeSats must be improved in order to perform more ambitious missions. Electric propulsion systems will play a key role due to their large specific impulse. Compared to other propulsion alternatives, their simplicity allows an easier miniaturization and manufacturing of autonomous modules into the nano and pico-satellite platform. Pulsed Plasma Thrusters (PPTs) appear as one of the most promising technologies for the near term. The utilization of solid and non-volatile propellants, their low power requirements and their proven reliability in the large scale make them great candidates for rapid implementation. The main challenges are the integration and miniaturization of all the electronic circuitry into a printed circuit board (PCB) that can satisfy the strict requirements that CubeSats present. NASA Ames and the George Washington University have demonstrated functionality and control of three discrete Micro-Cathode Arc Thrusters (CAT) using a bench top configuration that was compatible with the ARC PhoneSat Bus. This demonstration was successfully conducted in a vaccum chamber at the ARC Environmental Test Laboratory. A new effort will integrate a low power Plasma Processing Unit and two plasma thrusters onto a single printed circuit board that will utilize less than 13 U of Bus volume. The target design will be optimized for the accommodation into the PhoneSatEDISON Demonstration of SmallSatellite Networks (EDSN) bus as it uses the same software interface application, which was demonstrated in the previous task. This paper describes the design, integration and architecture of the proposed propulsion subsystem for a planned Technology Demonstration Mission. In addition, a general review of the Pulsed Plasma technology available for CubeSats is presented in order to assess the necessary challenges to overcome further development.

Organization of excitable dynamics in hierarchical biological networks.

PubMed

Müller-Linow, Mark; Hilgetag, Claus C; Hütt, Marc-Thorsten

2008-09-26

This study investigates the contributions of network topology features to the dynamic behavior of hierarchically organized excitable networks. Representatives of different types of hierarchical networks as well as two biological neural networks are explored with a three-state model of node activation for systematically varying levels of random background network stimulation. The results demonstrate that two principal topological aspects of hierarchical networks, node centrality and network modularity, correlate with the network activity patterns at different levels of spontaneous network activation. The approach also shows that the dynamic behavior of the cerebral cortical systems network in the cat is dominated by the network's modular organization, while the activation behavior of the cellular neuronal network of Caenorhabditis elegans is strongly influenced by hub nodes. These findings indicate the interaction of multiple topological features and dynamic states in the function of complex biological networks.

Management process invaded Ames as the Center shifted from NACA to NASA oversight. Ames constructed

NASA Technical Reports Server (NTRS)

1968-01-01

Management process invaded Ames as the Center shifted from NACA to NASA oversight. Ames constructed a review room in its headquarters building where, in the graphical style that prevailed in the 1960's, Ames leadership could review progress against schedule, budget and performance measures. Shown, in October 1965 is Merrill Mead chief of Ames' program and resources office. (for H Julian Allen Retirement album)

Modeling Nitrogen Processing in Northeast US River Networks

NASA Astrophysics Data System (ADS)

Whittinghill, K. A.; Stewart, R.; Mineau, M.; Wollheim, W. M.; Lammers, R. B.

2013-12-01

Due to increased nitrogen (N) pollution from anthropogenic sources, the need for aquatic ecosystem services such as N removal has also increased. River networks provide a buffering mechanism that retains or removes anthropogenic N inputs. However, the effectiveness of N removal in rivers may decline with increased loading and, consequently, excess N is eventually delivered to estuaries. We used a spatially distributed river network N removal model developed within the Framework for Aquatic Modeling in the Earth System (FrAMES) to examine the geography of N removal capacity of Northeast river systems under various land use and climate conditions. FrAMES accounts for accumulation and routing of runoff, water temperatures, and serial biogeochemical processing using reactivity derived from the Lotic Intersite Nitrogen Experiment (LINX2). Nonpoint N loading is driven by empirical relationships with land cover developed from previous research in Northeast watersheds. Point source N loading from wastewater treatment plants is estimated as a function of the population served and the volume of water discharged. We tested model results using historical USGS discharge data and N data from historical grab samples and recently initiated continuous measurements from in-situ aquatic sensors. Model results for major Northeast watersheds illustrate hot spots of ecosystem service activity (i.e. N removal) using high-resolution maps and basin profiles. As expected, N loading increases with increasing suburban or agricultural land use area. Network scale N removal is highest during summer and autumn when discharge is low and river temperatures are high. N removal as the % of N loading increases with catchment size and decreases with increasing N loading, suburban land use, or agricultural land use. Catchments experiencing the highest network scale N removal generally have N inputs (both point and non-point sources) located in lower order streams. Model results can be used to better predict nutrient loading to the coastal ocean across a broad range of current and future climate variability.

The State-of-Play of Anomalous Microwave Emission (AME) research

NASA Astrophysics Data System (ADS)

Dickinson, Clive; Ali-Haïmoud, Y.; Barr, A.; Battistelli, E. S.; Bell, A.; Bernstein, L.; Casassus, S.; Cleary, K.; Draine, B. T.; Génova-Santos, R.; Harper, S. E.; Hensley, B.; Hill-Valler, J.; Hoang, Thiem; Israel, F. P.; Jew, L.; Lazarian, A.; Leahy, J. P.; Leech, J.; López-Caraballo, C. H.; McDonald, I.; Murphy, E. J.; Onaka, T.; Paladini, R.; Peel, M. W.; Perrott, Y.; Poidevin, F.; Readhead, A. C. S.; Rubiño-Martín, J.-A.; Taylor, A. C.; Tibbs, C. T.; Todorović, M.; Vidal, Matias

2018-02-01

Anomalous Microwave Emission (AME) is a component of diffuse Galactic radiation observed at frequencies in the range ≈ 10-60 GHz. AME was first detected in 1996 and recognised as an additional component of emission in 1997. Since then, AME has been observed by a range of experiments and in a variety of environments. AME is spatially correlated with far-IR thermal dust emission but cannot be explained by synchrotron or free-free emission mechanisms, and is far in excess of the emission contributed by thermal dust emission with the power-law opacity consistent with the observed emission at sub-mm wavelengths. Polarization observations have shown that AME is very weakly polarized ( ≲ 1 %). The most natural explanation for AME is rotational emission from ultra-small dust grains ("spinning dust"), first postulated in 1957. Magnetic dipole radiation from thermal fluctuations in the magnetization of magnetic grain materials may also be contributing to the AME, particularly at higher frequencies ( ≳ 50 GHz). AME is also an important foreground for Cosmic Microwave Background analyses. This paper presents a review and the current state-of-play in AME research, which was discussed in an AME workshop held at ESTEC, The Netherlands, June 2016.

PROMIS PF CAT Outperforms the ODI and SF-36 Physical Function Domain in Spine Patients.

PubMed

Brodke, Darrel S; Goz, Vadim; Voss, Maren W; Lawrence, Brandon D; Spiker, William Ryan; Hung, Man

2017-06-15

The Oswestry Disability Index v2.0 (ODI), SF36 Physical Function Domain (SF-36 PFD), and PROMIS Physical Function CAT v1.2 (PF CAT) questionnaires were prospectively collected from 1607 patients complaining of back or leg pain, visiting a university-based spine clinic. All questionnaires were collected electronically, using a tablet computer. The aim of this study was to compare the psychometric properties of the PROMIS PF CAT with the ODI and SF36 Physical Function Domain in the same patient population. Evidence-based decision-making is improved by using high-quality patient-reported outcomes measures. Prior studies have revealed the shortcomings of the ODI and SF36, commonly used in spine patients. The PROMIS Network has developed measures with excellent psychometric properties. The Physical Function domain, delivered by Computerized Adaptive Testing (PF CAT), performs well in the spine patient population, though to-date direct comparisons with common measures have not been performed. Standard Rasch analysis was performed to directly compare the psychometrics of the PF CAT, ODI, and SF36 PFD. Spearman correlations were computed to examine the correlations of the three instruments. Time required for administration was also recorded. One thousand six hundred seven patients were administered all assessments. The time required to answer all items in the PF CAT, ODI, and SF-36 PFD was 44, 169, and 99 seconds. The ceiling and floor effects were excellent for the PF CAT (0.81%, 3.86%), while the ceiling effects were marginal and floor effects quite poor for the ODI (6.91% and 44.24%) and SF-36 PFD (5.97% and 23.65%). All instruments significantly correlated with each other. The PROMIS PF CAT outperforms the ODI and SF-36 PFD in the spine patient population and is highly correlated. It has better coverage, while taking less time to administer with fewer questions to answer. 2.

IsoWAN: A NASA Science and Engineering Information and Services Framework

NASA Technical Reports Server (NTRS)

Korsmeyer, David J.; Chow, Edward T.; Conroy, Michael P.; Swanson, Keith (Technical Monitor)

2000-01-01

We believe that the next evolutionary step in supporting wide-area application and services delivery to customers is a network framework that provides for collocation of applications and services at distinct sites in the network, an interconnection between these sites that is performance optimized for these applications, and value-added services for applications. We use the term IsoWAN to describe an advanced, isolated network interconnect services framework that will enable applications to be more secure, and able to access and be in use in both local and remote environments. The main functions of an IsoWAN are virtual localization of application services, an application service interface, coordinated delivery of applications and associated data to the customer, and supporting collaborative application development for customers. An initial pilot network between three NASA Centers: Ames Research Center, the Jet Propulsion Laboratory, and Marshall Space Flight Center, has been built and its properties will be discussed.

A CASE AGAINST SPINNING PAHS AS THE SOURCE OF THE ANOMALOUS MICROWAVE EMISSION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hensley, Brandon S.; Draine, B. T.; Meisner, Aaron M., E-mail: brandon.s.hensley@jpl.nasa.gov

2016-08-10

We employ an all-sky map of the anomalous microwave emission (AME) produced by component separation of the microwave sky to study correlations between the AME and Galactic dust properties. We find that while the AME is highly correlated with all tracers of dust emission, the best predictor of the AME strength is the dust radiance. Fluctuations in the AME intensity per dust radiance are uncorrelated with fluctuations in the emission from polycyclic aromatic hydrocarbons (PAHs), casting doubt on the association between AME and PAHs. The PAH abundance is strongly correlated with the dust optical depth and dust radiance, consistent withmore » PAH destruction in low density regions. We find that the AME intensity increases with increasing radiation field strength, at variance with predictions from the spinning dust hypothesis. Finally, the temperature dependence of the AME per dust radiance disfavors the interpretation of the AME as thermal emission. A reconsideration of other AME carriers, such as ultrasmall silicates, and other emission mechanisms, such as magnetic dipole emission, is warranted.« less

Application of fuzzy logic-neural network based reinforcement learning to proximity and docking operations

NASA Technical Reports Server (NTRS)

Jani, Yashvant

1992-01-01

As part of the Research Institute for Computing and Information Systems (RICIS) activity, the reinforcement learning techniques developed at Ames Research Center are being applied to proximity and docking operations using the Shuttle and Solar Max satellite simulation. This activity is carried out in the software technology laboratory utilizing the Orbital Operations Simulator (OOS). This interim report provides the status of the project and outlines the future plans.

Report of the Interagency Optical Network Testbeds Workshop 2 September 12-14, 2006 NASA Ames Research Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joe Mambretti Richard desJardins

2006-05-01

A new generation of optical networking services and technologies is rapidly changing the world of communications. National and international networks are implementing optical services to supplement traditional packet routed services. On September 12-14, 2005, the Optical Network Testbeds Workshop 2 (ONT2), an invitation-only forum hosted by the NASA Research and Engineering Network (NREN) and co-sponsored by the Department of Energy (DOE), was held at NASA Ames Research Center in Mountain View, California. The aim of ONT2 was to help the Federal Large Scale Networking Coordination Group (LSN) and its Joint Engineering Team (JET) to coordinate testbed and network roadmaps describingmore » agency and partner organization views and activities for moving toward next generation communication services based on leading edge optical networks in the 3-5 year time frame. ONT2 was conceived and organized as a sequel to the first Optical Network Testbeds Workshop (ONT1, August 2004, www.nren.nasa.gov/workshop7). ONT1 resulted in a series of recommendations to LSN. ONT2 was designed to move beyond recommendations to agree on a series of “actionable objectives” that would proactively help federal and partner optical network testbeds and advanced research and education (R&E) networks to begin incorporating technologies and services representing the next generation of advanced optical networks in the next 1-3 years. Participants in ONT2 included representatives from innovative prototype networks (Panel A), basic optical network research testbeds (Panel B), and production R&D networks (Panels C and D), including “JETnets,” selected regional optical networks (RONs), international R&D networks, commercial network technology and service providers (Panel F), and senior engineering and R&D managers from LSN agencies and partner organizations. The overall goal of ONT2 was to identify and coordinate short and medium term activities and milestones for researching, developing, identifying, evaluating, and implementing the services, technologies, and interoperability mechanisms required. The roadmaps were formulated and presented not so much to reconcile the roadmaps with each other but rather to provide a means to compare the major ongoing and planned optical networking activities in the R&E community, organized by categories of activities and communities of interest. In addition, a 5-15 year network research perspective was provided by Panel E, which presented a report on two recent National Science Foundation workshops that examined long term research goals and directions, and industry perspectives on forthcoming optical networking technologies and services were presented in Panel F by representatives from optical technologies and network services industries. The report, “Mapping a Future for Optical Networking and Communications” is available on the NSF website (www.nsf.gov), and the industry perspectives will be available on the ONT2 website.« less

Image Understanding by Image-Seeking Adaptive Networks (ISAN).

DTIC Science & Technology

1987-08-10

our reserch on adaptive neural networks in the visual and sensory-motor cortex of cats. We demonstrate that, under certain conditions, plasticity is...understanding in organisms proceeds directly from adaptively seeking whole images and not via a preliminary analysis of elementary features, followed by object...empirical reserch has always been that ultimately any neural system has to serve behavior and that behavior serves survival. Evolutionary selection makes it

Ames Engineering Directorate

NASA Technical Reports Server (NTRS)

Phillips, Veronica J.

2017-01-01

The Ames Engineering Directorate is the principal engineering organization supporting aerospace systems and spaceflight projects at NASA's Ames Research Center in California's Silicon Valley. The Directorate supports all phases of engineering and project management for flight and mission projects-from R&D to Close-out-by leveraging the capabilities of multiple divisions and facilities.The Mission Design Center (MDC) has full end-to-end mission design capability with sophisticated analysis and simulation tools in a collaborative concurrent design environment. Services include concept maturity level (CML) maturation, spacecraft design and trades, scientific instruments selection, feasibility assessments, and proposal support and partnerships. The Engineering Systems Division provides robust project management support as well as systems engineering, mechanical and electrical analysis and design, technical authority and project integration support to a variety of programs and projects across NASA centers. The Applied Manufacturing Division turns abstract ideas into tangible hardware for aeronautics, spaceflight and science applications, specializing in fabrication methods and management of complex fabrication projects. The Engineering Evaluation Lab (EEL) provides full satellite or payload environmental testing services including vibration, temperature, humidity, immersion, pressure/altitude, vacuum, high G centrifuge, shock impact testing and the Flight Processing Center (FPC), which includes cleanrooms, bonded stores and flight preparation resources. The Multi-Mission Operations Center (MMOC) is composed of the facilities, networks, IT equipment, software and support services needed by flight projects to effectively and efficiently perform all mission functions, including planning, scheduling, command, telemetry processing and science analysis.

Performance Evaluation of Communication Software Systems for Distributed Computing

NASA Technical Reports Server (NTRS)

Fatoohi, Rod

1996-01-01

In recent years there has been an increasing interest in object-oriented distributed computing since it is better quipped to deal with complex systems while providing extensibility, maintainability, and reusability. At the same time, several new high-speed network technologies have emerged for local and wide area networks. However, the performance of networking software is not improving as fast as the networking hardware and the workstation microprocessors. This paper gives an overview and evaluates the performance of the Common Object Request Broker Architecture (CORBA) standard in a distributed computing environment at NASA Ames Research Center. The environment consists of two testbeds of SGI workstations connected by four networks: Ethernet, FDDI, HiPPI, and ATM. The performance results for three communication software systems are presented, analyzed and compared. These systems are: BSD socket programming interface, IONA's Orbix, an implementation of the CORBA specification, and the PVM message passing library. The results show that high-level communication interfaces, such as CORBA and PVM, can achieve reasonable performance under certain conditions.

Advanced Therapy Medicinal Products: How to Bring Cell-Based Medicinal Products Successfully to the Market - Report from the CAT-DGTI-GSCN Workshop at the DGTI Annual Meeting 2014.

PubMed

Celis, Patrick; Ferry, Nicolas; Hystad, Marit; Schüßler-Lenz, Martina; Doevendans, Pieter A; Flory, Egbert; Beuneu, Claire; Reischl, Ilona; Salmikangas, Paula

2015-05-01

On September 11, 2014, a workshop entitled 'Advanced Therapy Medicinal Products: How to Bring Cell-Based Medicinal Product Successfully to the Market' was held at the 47th annual meeting of the German Society for Transfusion Medicine and Immunohematology (DGTI), co-organised by the European Medicines Agency (EMA) and the DGTI in collaboration with the German Stem Cell Network (GSCN). The workshop brought together over 160 participants from academia, hospitals, small- or medium-sized enterprise developers and regulators. At the workshop, speakers from EMA, the Committee for Advanced Therapies (CAT), industry and academia addressed the regulatory aspects of development and authorisation of advanced therapy medicinal products (ATMPs), classification of ATMPs and considerations on cell-based therapies for cardiac repair. The open forum discussion session allowed for a direct interaction between ATMP developers and the speakers from EMA and CAT.

Antimicrobial and Antibiofilm Effects of Human Amniotic/Chorionic Membrane Extract on Streptococcus pneumoniae

PubMed Central

Yadav, Mukesh K.; Go, Yoon Y.; Kim, Shin Hye; Chae, Sung-Won; Song, Jae-Jun

2017-01-01

Background: Streptococcus pneumoniae colonize the human nasopharynx in the form of biofilms. The biofilms act as bacterial reservoirs and planktonic bacteria from these biofilms can migrate to other sterile anatomical sites to cause pneumonia, otitis media (OM), bacteremia and meningitis. Human amniotic membrane contains numerous growth factors and antimicrobial activity; however, these have not been studied in detail. In this study, we prepared amniotic membrane extract and chorionic membrane extract (AME/CME) and evaluated their antibacterial and antibiofilm activities against S. pneumoniae using an in vitro biofilm model and in vivo OM rat model. Materials and Methods: The AME/CME were prepared and protein was quantified using DCTM (detergent compatible) method. The minimum inhibitory concentrations were determined using broth dilution method, and the synergistic effect of AME/CME with Penicillin-streptomycin was detected checkerboard. The in vitro biofilm and in vivo colonization of S. pneumoniae were studied using microtiter plate assay and OM rat model, respectively. The AME/CME-treated biofilms were examined using scanning electron microscope and confocal microscopy. To examine the constituents of AME/CME, we determined the proteins and peptides of AME/CME using tandem mass tag-based quantitative mass spectrometry. Results: AME/CME treatment significantly (p < 0.05) inhibited S. pneumoniae growth in planktonic form and in biofilms. Combined application of AME/CME and Penicillin-streptomycin solution had a synergistic effect against S. pneumoniae. Biofilms grown with AME/CME were thin, scattered, and unorganized. AME/CME effectively eradicated pre-established pneumococci biofilms and has a bactericidal effect. AME treatment significantly (p < 0.05) reduced bacterial colonization in the rat middle ear. The proteomics analysis revealed that the AME/CME contains hydrolase, ribonuclease, protease, and other antimicrobial proteins and peptides. Conclusion: AME/CME inhibits S. pneumoniae growth in the planktonic and biofilm states via its antimicrobial proteins and peptides. AME/CME are non-cytotoxic, natural human product; therefore, they may be used alone or with antibiotics to treat S. pneumoniae infections. PMID:29089928

The Ames Project (1942-1946)

ScienceCinema

None

2018-04-26

The Ames Laboratory was officially founded on May 17, 1947, following development of a process to purify uranium metal for the historic Manhattan Project. From 1942 to 1946, Ames Lab scientists produced over two-million pounds of uranium metal. A U.S. Department of Energy national research laboratory, the Ames Laboratory creates materials and energy solutions. Iowa State University operates Ames Laboratory under contract with the DOE.

Alcohol Mixed with Energy Drinks: Daily Context of Use.

PubMed

Linden-Carmichael, Ashley N; Lau-Barraco, Cathy

2017-04-01

The link between use of alcohol mixed with energy drinks (AmEDs) and alcohol-related harms is well established, but limited research has examined the context in which AmEDs are consumed. Identifying the social and environmental characteristics of use may illuminate whether AmEDs are used in settings that could increase the likelihood of engaging in risky behaviors or experiencing harms. This study used a 2-week daily diary assessment to compare days in which AmEDs were consumed ("AmED days") and days where other types of alcohol were used ("non-AmED days") on where, when, and with whom drinking occurred. Participants were 122 (90 women) heavy drinking college students who reported mixing caffeine with alcohol at least once in the past week. Data were collected across 389 drinking days; 40 of these days involved AmED use. Multilevel modeling findings revealed that odds of drinking AmEDs were higher on days where individuals drank at a bar or club and drank at home relative to other locations. In addition, odds of pregaming were higher on AmED days as compared to non-AmED days. AmED use was linked with lower odds of drinking game behavior. Overall, AmEDs appear to be consumed in potentially risky contexts. In combination with prior findings that AmED days are linked with heavier alcohol use and more harms experienced, these findings support the unique nature of AmED consumption in terms of the factors that may predict or maintain potentially hazardous drinking patterns. Copyright © 2017 by the Research Society on Alcoholism.

Numerical aerodynamic simulation program long haul communications prototype

NASA Technical Reports Server (NTRS)

Cmaylo, Bohden K.; Foo, Lee

1987-01-01

This document is a report of the Numerical Aerodynamic Simulation (NAS) Long Haul Communications Prototype (LHCP). It describes the accomplishments of the LHCP group, presents the results from all LHCP experiments and testing activities, makes recommendations for present and future LHCP activities, and evaluates the remote workstation accesses from Langley Research Center, Lewis Research Center, and Colorado State University to Ames Research Center. The report is the final effort of the Long Haul (Wideband) Communications Prototype Plan (PT-1133-02-N00), 3 October 1985, which defined the requirements for the development, test, and operation of the LHCP network and was the plan used to evaluate the remote user bandwidth requirements for the Numerical Aerodynamic Simulation Processing System Network.

Neural Network Based Modeling and Analysis of LP Control Surface Allocation

NASA Technical Reports Server (NTRS)

Langari, Reza; Krishnakumar, Kalmanje; Gundy-Burlet, Karen

2003-01-01

This paper presents an approach to interpretive modeling of LP based control allocation in intelligent flight control. The emphasis is placed on a nonlinear interpretation of the LP allocation process as a static map to support analytical study of the resulting closed loop system, albeit in approximate form. The approach makes use of a bi-layer neural network to capture the essential functioning of the LP allocation process. It is further shown via Lyapunov based analysis that under certain relatively mild conditions the resulting closed loop system is stable. Some preliminary conclusions from a study at Ames are stated and directions for further research are given at the conclusion of the paper.

76 FR 22900 - Decision To Evaluate a Petition To Designate a Class of Employees From Ames Laboratory in Ames...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-25

... as follows: Facility: Ames Laboratory. Location: Ames, Iowa. Job Titles and/or Job Duties: All.... FOR FURTHER INFORMATION CONTACT: Stuart L. Hinnefeld, Director, Division of Compensation Analysis and...

ARC-1965-A-34401

NASA Image and Video Library

1965-04-22

Vance I. Oyama at the Gas Chromatograph in Ames' life detection laboratory, Vance and his brother Jiro both pioneered new areas of life sciences research at Ames. Publication: Ames History; Atmosphere of Freedom; 60 yrs at NASA Ames NASA SP-2000-4314

Microphone Array Phased Processing System (MAPPS): Version 4.0 Manual

NASA Technical Reports Server (NTRS)

Watts, Michael E.; Mosher, Marianne; Barnes, Michael; Bardina, Jorge

1999-01-01

A processing system has been developed to meet increasing demands for detailed noise measurement of individual model components. The Microphone Array Phased Processing System (MAPPS) uses graphical user interfaces to control all aspects of data processing and visualization. The system uses networked parallel computers to provide noise maps at selected frequencies in a near real-time testing environment. The system has been successfully used in the NASA Ames 7- by 10-Foot Wind Tunnel.

Automated Help System For A Supercomputer

NASA Technical Reports Server (NTRS)

Callas, George P.; Schulbach, Catherine H.; Younkin, Michael

1994-01-01

Expert-system software developed to provide automated system of user-helping displays in supercomputer system at Ames Research Center Advanced Computer Facility. Users located at remote computer terminals connected to supercomputer and each other via gateway computers, local-area networks, telephone lines, and satellite links. Automated help system answers routine user inquiries about how to use services of computer system. Available 24 hours per day and reduces burden on human experts, freeing them to concentrate on helping users with complicated problems.

Extraterrestrial intelligence? The search is on

NASA Technical Reports Server (NTRS)

Coulter, Gary R.

1991-01-01

NASA's SETI-Microwave Observing Project, beginning on October 12, 1992, will search the closest solar-type stars for radio signals from extraterrestrial civilizations. When completed in the year 2000, the NASA search will have surpassed the search volume of all prior searches by a factor of 10 exp 10. The world's largest radio telescopes will be employed, in conjunction with the NASA Deep Space Network communications antennas. The program will be led by NASA-Ames, with substantial contribution by JPL.

Ames Lab 101: Danny Shechtman Returns to the Ames Laboratory

ScienceCinema

Shechtman, Danny

2018-05-07

Danny Shechtman, Ames Laboratory Scientist and winner of the Nobel Prize in Chemistry 2011, returned to the Ames Lab on February 14, 2012. During this time, the Nobel Laureate met with the press as well as ISU students.

ARC-2006-ACD06-0113-006

NASA Image and Video Library

2006-07-05

Spaceward Bound Program in Atacama Desert; shown here is a realtime webcast from Yungay, Chile vis satellite involving NASA Scientists and seven NASA Explorer school teachers. On the Ames end we find the Girl Scouts Space cookines robotic team. The robot nicknamed Zoe is looking for life in extreme environments in preparation for what might be encounter on Mars. (back row l-r) Yvonne Clearwater, Ames Education Division, Donald James, Ames Education Division Chief, Pete Worden, Ames Center Director, Angela Diaz, Ames Director of Strategic Communications) see full text on the NASA-Ames News - Research # 04-91AR

Patterns of antimicrobial agent prescription in a sentinel population of canine and feline veterinary practices in the United Kingdom.

PubMed

Singleton, D A; Sánchez-Vizcaíno, F; Dawson, S; Jones, P H; Noble, P J M; Pinchbeck, G L; Williams, N J; Radford, A D

2017-06-01

Antimicrobial resistance is an increasingly important global health threat and the use of antimicrobial agents is a key risk factor in its development. This study describes antimicrobial agent prescription (AAP) patterns over a 2year period using electronic health records (EHRs) from booked consultations in a network of 457 sentinel veterinary premises in the United Kingdom. A semi-automated classification methodology was used to map practitioner defined product codes in 918,333 EHRs from 413,870 dogs and 352,730 EHRs from 200,541 cats, including 289,789 AAPs. AAP as a proportion of total booked consultations was more frequent in dogs (18.8%, 95% confidence interval, CI, 18.2-19.4) than cats (17.5%, 95% CI 16.9-18.1). Prescription of topical antimicrobial agents was more frequent in dogs (7.4%, 95% CI 7.2-7.7) than cats (3.2%, 95% CI 3.1-3.3), whilst prescription of systemic antimicrobial agents was more frequent in cats (14.8%, 95% CI 14.2-15.4) than dogs (12.2%, 95% CI 11.7-12.7). A decreasing temporal pattern was identified for prescription of systemic antimicrobial agents in dogs and cats. Premises which prescribed antimicrobial agents frequently for dogs also prescribed frequently for cats. AAP was most frequent during pruritus consultations in dogs and trauma consultations in cats. Clavulanic acid potentiated amoxicillin was the most frequently prescribed antimicrobial agent in dogs (28.6% of prescriptions, 95% CI 27.4-29.8), whereas cefovecin, a third generation cephalosporin, was the most frequently prescribed antimicrobial agent in cats (36.2%, 95% CI 33.9-38.5). This study demonstrated patterns in AAP over time and for different conditions in a population of companion animals in the United Kingdom. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Network-Guided GWAS Improves Identification of Genes Affecting Free Amino Acids.

PubMed

Angelovici, Ruthie; Batushansky, Albert; Deason, Nicholas; Gonzalez-Jorge, Sabrina; Gore, Michael A; Fait, Aaron; DellaPenna, Dean

2017-01-01

Amino acids are essential for proper growth and development in plants. Amino acids serve as building blocks for proteins but also are important for responses to stress and the biosynthesis of numerous essential compounds. In seed, the pool of free amino acids (FAAs) also contributes to alternative energy, desiccation, and seed vigor; thus, manipulating FAA levels can significantly impact a seed's nutritional qualities. While genome-wide association studies (GWAS) on branched-chain amino acids have identified some regulatory genes controlling seed FAAs, the genetic regulation of FAA levels, composition, and homeostasis in seeds remains mostly unresolved. Hence, we performed GWAS on 18 FAAs from a 313-ecotype Arabidopsis (Arabidopsis thaliana) association panel. Specifically, GWAS was performed on 98 traits derived from known amino acid metabolic pathways (approach 1) and then on 92 traits generated from an unbiased correlation-based metabolic network analysis (approach 2), and the results were compared. The latter approach facilitated the discovery of additional novel metabolic interactions and single-nucleotide polymorphism-trait associations not identified by the former approach. The most prominent network-guided GWAS signal was for a histidine (His)-related trait in a region containing two genes: a cationic amino acid transporter (CAT4) and a polynucleotide phosphorylase resistant to inhibition with fosmidomycin. A reverse genetics approach confirmed CAT4 to be responsible for the natural variation of His-related traits across the association panel. Given that His is a semiessential amino acid and a potent metal chelator, CAT4 orthologs could be considered as candidate genes for seed quality biofortification in crop plants. © 2017 American Society of Plant Biologists. All Rights Reserved.

ARC-2007-ACD07-0073-126

NASA Image and Video Library

2007-08-07

LCROSS flight hardware in clean room at Ames N-240. EEL personnel fabricating testing components with Jerry Wang of Ames, Engineering Evaluation labLCROSS flight hardware in clean room at Ames N-240. EEL personnel fabricating testing components with Jerry Wang of Ames, Engineering Evaluation lab

We Are Ames

NASA Image and Video Library

2015-01-26

Ames Research Center, one of NASA's ten field Centers, is located in the heart of California's Silicon Valley. For 75 years, Ames has led the Agency and the country in conducting world-class research and development. Let some of Ames' employees tell you about the work that they do.

The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC): verification of nasal allergen challenge procedures in a study utilizing an investigational immunotherapy for cat allergy.

PubMed

Neighbour, Helen; Soliman, Mena; Steacy, Lisa M; Hickey, Pascal; Forbes, Beth; Larché, Mark; Ellis, Anne K

2018-01-01

The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a network of experienced Allergic Rhinitis (AR) researchers developing better research tools based on the nasal allergen challenge (NAC). A key objective of such is the ability to detect efficacy in a small population. AR-CIC sought to test its NAC protocol as a secondary objective in two small mechanistic research trials of a novel form of immunotherapy [Cat Peptide Antigen Desensitisation (Cat-PAD)] for which efficacy had previously been demonstrated. The primary objective (not presented here) was to identify potential biomarkers of efficacy for peptide immunotherapy, and this provided an ideal opportunity to corroborate the NAC protocol. We aim to clinically validate the AR-CIC NAC methodology in a pooled analysis of secondary endpoints measured in two open label mechanistic studies of cat allergic participants treated with Cat-PAD. Cat allergic AR sufferers with ongoing cat exposure were included. Participants had to demonstrate a total nasal symptom score (TNSS) of at least 8 (max 12) and/or achieve a reduction in peak nasal inspiratory flow (PNIF) of ≥ 50% during a screening titrated NAC. Eligible participants then underwent a baseline NAC visit with the allergen dose that produced a positive challenge at screening, followed by four monthly injections of 6 nmol Cat-PAD. A follow up NAC visit documented changes in nasal response 1 month following the completion of treatment. Nineteen subjects completed the study protocol in the two studies combined. Four injections of Cat-PAD resulted in a significant reduction in TNSS responses generated via NAC following allergen challenge (15 min p  < 0.05, 30 min p  < 0.05, 1 h p  < 0.01, 2 h p  < 0.05). There was modest correlation between symptom scores and PNIF measurements. This study supports the validity of the AR-CIC's optimised NAC protocol for conducting research of the potential efficacy of novel therapeutics in multi-centre studies. Trial registration Both studies reported herein were registered clinicaltrials.gov (NCT01383590 and NCT01383603).

The "beneficial" effects of locomotor training after various types of spinal lesions in cats and rats.

PubMed

Rossignol, Serge; Martinez, Marina; Escalona, Manuel; Kundu, Aritra; Delivet-Mongrain, Hugo; Alluin, Olivier; Gossard, Jean-Pierre

2015-01-01

This chapter reviews a number of experiments on the recovery of locomotion after various types of spinal lesions and locomotor training mainly in cats. We first recall the major evidence on the recovery of hindlimb locomotion in completely spinalized cats at the T13 level and the role played by the spinal locomotor network, also known as the central pattern generator, as well as the beneficial effects of locomotor training on this recovery. Having established that hindlimb locomotion can recover, we raise the issue as to whether spinal plastic changes could also contribute to the recovery after partial spinal lesions such as unilateral hemisections. We found that after such hemisection at T10, cats could recover quadrupedal locomotion and that deficits could be improved by training. We further showed that, after a complete spinalization a few segments below the first hemisection (at T13, i.e., the level of previous studies on spinalization), cats could readily walk with the hindlimbs within hours of completely severing the remaining spinal tracts and not days as is usually the case with only a single complete spinalization. This suggests that neuroplastic changes occurred below the first hemisection so that the cat was already primed to walk after the spinalization subsequent to the hemispinalization 3 weeks before. Of interest is the fact that some characteristic kinematic features in trained or untrained hemispinalized cats could remain after complete spinalization, suggesting that spinal changes induced by training could also be durable. Other studies on reflexes and on the pattern of "fictive" locomotion recorded after curarization corroborate this view. More recent work deals with training cats in more demanding situations such as ladder treadmill (vs. flat treadmill) to evaluate how the locomotor training regimen can influence the spinal cord. Finally, we report our recent studies in rats using compressive lesions or surgical complete spinalization and find that some principles of locomotor recovery in cats also apply to rats when adequate locomotor training is provided. © 2015 Elsevier B.V. All rights reserved.

Changes in Structural-Mechanical Properties and Degradability of Collagen during Aging-associated Modifications*

PubMed Central

Panwar, Preety; Lamour, Guillaume; Mackenzie, Neil C. W.; Yang, Heejae; Ko, Frank; Li, Hongbin; Brömme, Dieter

2015-01-01

During aging, changes occur in the collagen network that contribute to various pathological phenotypes in the skeletal, vascular, and pulmonary systems. The aim of this study was to investigate the consequences of age-related modifications on the mechanical stability and in vitro proteolytic degradation of type I collagen. Analyzing mouse tail and bovine bone collagen, we found that collagen at both fibril and fiber levels varies in rigidity and Young's modulus due to different physiological changes, which correlate with changes in cathepsin K (CatK)-mediated degradation. A decreased susceptibility to CatK-mediated hydrolysis of fibrillar collagen was observed following mineralization and advanced glycation end product-associated modification. However, aging of bone increased CatK-mediated osteoclastic resorption by ∼27%, and negligible resorption was observed when osteoclasts were cultured on mineral-deficient bone. We observed significant differences in the excavations generated by osteoclasts and C-terminal telopeptide release during bone resorption under distinct conditions. Our data indicate that modification of collagen compromises its biomechanical integrity and affects CatK-mediated degradation both in bone and tissue, thus contributing to our understanding of extracellular matrix aging. PMID:26224630

Synaptic Plasticity in Visual Cortex: Comparison of Theory with Experiment

DTIC Science & Technology

1990-01-01

Hubel DH, Wiesel TN (1961) Integrative action in the cat’s lateral geniculate body . J. Physiol. 155:385-398. Hubel DH, Wiesel TN (1962) Receptive...fibers from the lateral geniculate nucleus (LGN) onto a single cortical neuron. Scofield and Cooper (1985) extended this to a network of interconnected...connected network was later 1 simplified by Cooper and Scofield (1988) with the introduction of a mean-field theory, which in effect replaces all of the

(New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Meets with

NASA Technical Reports Server (NTRS)

2002-01-01

(New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Meets with Roberto Cruz, National Hispanic University (seated, right) and Ames Center Director Dr. Henry McDonald follow the signing of the educational MOU between NHU and Ames.

(New) NASA Director Sean O'Keefe comes to Ames for employee briefing and tour. Meets with Roberto

NASA Technical Reports Server (NTRS)

2002-01-01

(New) NASA Director Sean O'Keefe comes to Ames for employee briefing and tour. Meets with Roberto Cruz, National Hispanic University (seated, right) and Ames Center Director Dr. Henry McDonald follow the signing of the educational MOU between NHU and Ames.

NASA Ames Environmental Sustainability Report 2011

NASA Technical Reports Server (NTRS)

Clarke, Ann H.

2011-01-01

The 2011 Ames Environmental Sustainability Report is the second in a series of reports describing the steps NASA Ames Research Center has taken toward assuring environmental sustainability in NASA Ames programs, projects, and activities. The Report highlights Center contributions toward meeting the Agency-wide goals under the 2011 NASA Strategic Sustainability Performance Program.

Welcome to Ames Research Center (1987 forum on Federal technology transfer)

NASA Technical Reports Server (NTRS)

Ballhaus, William F., Jr.

1988-01-01

NASA Ames Research Center has a long and distinguished history of technology development and transfer. Recently, in a welcoming speech to the Forum on Federal Technology Transfer, Director Ballhouse of Ames described significant technologies which have been transferred from Ames to the private sector and identifies future opportunities.

Nanotechnology at NASA Ames

NASA Technical Reports Server (NTRS)

Srivastava, Deepak; Meyyappan, Meyya; Yan, Jerry (Technical Monitor)

2000-01-01

Advanced miniaturization, a key thrust area to enable new science and exploration missions, provides ultrasmall sensors, power sources, communication, navigation, and propulsion systems with very low mass, volume, and power consumption. Revolutions in electronics and computing will allow reconfigurable, autonomous, 'thinking' spacecraft. Nanotechnology presents a whole new spectrum of opportunities to build device components and systems for entirely new space architectures: (1) networks of ultrasmall probes on planetary surfaces; (2) micro-rovers that drive, hop, fly, and burrow; and (3) collections of microspacecraft making a variety of measurements.

Ames Lab 101: Technology Transfer

ScienceCinema

Covey, Debra

2017-12-13

Ames Laboratory Associate Laboratory Director, Sponsored Research Administration, Debra Covey discusses technology transfer. Covey also discusses Ames Laboratory's most successful transfer, lead-free solder.

Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice

PubMed Central

McFadden, Samuel; Fang, Yimin; Huber, Joshua A.; Zhang, Chi; Sun, Liou Y.; Bartke, Andrzej

2016-01-01

Ames dwarf mice (Prop1df/df) are long-lived due to a loss of function mutation, resulting in deficiency of GH, TSH, and prolactin. Along with a marked extension of longevity, Ames dwarf mice have improved energy metabolism as measured by an increase in their oxygen consumption and heat production, as well as a decrease in their respiratory quotient. Along with alterations in energy metabolism, Ames dwarf mice have a lower core body temperature. Moreover, Ames dwarf mice have functionally altered epididymal white adipose tissue (WAT) that improves, rather than impairs, their insulin sensitivity due to a shift from pro- to anti-inflammatory cytokine secretion. Given the unique phenotype of Ames dwarf epididymal WAT, their improved energy metabolism, and lower core body temperature, we hypothesized that Ames dwarf brown adipose tissue (BAT) may function differently from that of their normal littermates. Here we use histology and RT-PCR to demonstrate that Ames dwarf mice have enhanced BAT function. We also use interscapular BAT removal to demonstrate that BAT is necessary for Ames dwarf energy metabolism and thermogenesis, whereas it is less important for their normal littermates. Furthermore, we show that Ames dwarf mice are able to compensate for loss of interscapular BAT by using their WAT depots as an energy source. These findings demonstrate enhanced BAT function in animals with GH and thyroid hormone deficiencies, chronic reduction of body temperature, and remarkably extended longevity. PMID:27740871

Motives for mixing alcohol with energy drinks and other non-alcoholic beverages and its effects on overall alcohol consumption among UK students.

PubMed

Johnson, Sean J; Alford, Chris; Verster, Joris C; Stewart, Karina

2016-01-01

A UK student survey examined the motivations for consuming energy drinks alone and mixed with alcohol, and aimed to determine whether the type of motive had a differential effect on overall alcohol consumption. The online survey (N = 1873) assessed alcohol consumption and motivations for consumption when mixed with energy drinks (AMED) and mixed with other non-alcoholic beverages (AMOB) using a within-subject design. The most frequent neutral motives reported for AMED consumption included "I like the taste" (66.5%), and "to celebrate a special occasion" (35.2%). 52.6% of AMED consumers reported consuming AMED for at least one of five negative motives, primarily "to get drunk" (45.6%). Despite these negative motives those students reported consuming significantly less alcohol and fewer negative alcohol-related consequences on AMED occasions compared to alcohol-only (AO) occasions. Although the motives for consuming AMED and AMOB were comparable, more participants reported consuming AMED "to celebrate a special occasion", "to get drunk", because they "received the drink from someone else" or "because others drink it as well". However, significantly more students reported consuming AMOB than AMED because "It feels like I can drink more alcohol". Alcohol consumption was significantly less on AMED occasions compared to AMOB occasions, and both occasions significantly less than AO occasions. The majority of reasons for consuming AMED relate to neutral motives. Although 52.6% of students reported one or more negative motives for AMED consumption (predominantly "to get drunk") this had no differential effect on total alcohol consumption. The differences in motives suggest AMED is consumed more to enjoy special occasions and as a group-bonding experience, however alcohol consumption is significantly lower on such occasions in comparison to when AMOB or AO are consumed. Copyright © 2015. Published by Elsevier Ltd.

A pulse-forming network for particle path visualization. [at Ames Aeromechanics Water Tunnel Facility

NASA Technical Reports Server (NTRS)

Mcalister, K. W.

1981-01-01

A procedure is described for visualizing nonsteady fluid flow patterns over a wide velocity range using discrete nonluminous particles. The paramount element responsible for this capability is a pulse-forming network with variable inductance that is used to modulate the discharge of a fixed amount of electrical energy through a xenon flashtube. The selectable duration of the resultant light emission functions as a variable shutter so that particle path images of constant length can be recorded. The particles employed as flow markers are hydrogen bubbles that are generated by electrolysis in a water tunnel. Data are presented which document the characteristics of the electrical circuit and establish the relation of particle velocity to both section inductance and film exposure.

Structural and magnetic properties of two- and three-dimensional molecule-based magnets (cat) +[M IIM III(C 2O 4) 3] -

NASA Astrophysics Data System (ADS)

Ovanesyan, Nikolai S.; Shilov, Gena V.; Pyalling, Alex A.; Train, Cyrille; Gredin, Patrick; Gruselle, Michel; Kiss, László F.; Bottyán, László

2004-05-01

We discuss the different structural arrangements of NBu 4[Fe IICr III(C 2O 4) 3] layered compounds in their racemic and enantiomeric forms and related magnetic properties. For [Mn IIFe III(C 2O 4) 3] networks of dimensionalities 2 and 3 Mössbauer spectroscopy was applied to study the Fe III sublattice magnetization. Unusual magnetic relaxation phenomena below TN were observed for both 2D and 3D networks.

NSI customer service representatives and user support office: NASA Science Internet

NASA Technical Reports Server (NTRS)

1991-01-01

The NASA Science Internet, (NSI) was established in 1987 to provide NASA's Offices of Space Science and Applications (OSSA) missions with transparent wide-area data connectivity to NASA's researchers, computational resources, and databases. The NSI Office at NASA/Ames Research Center has the lead responsibility for implementing a total, open networking program to serve the OSSA community. NSI is a full-service communications provider whose services include science network planning, network engineering, applications development, network operations, and network information center/user support services. NSI's mission is to provide reliable high-speed communications to the NASA science community. To this end, the NSI Office manages and operates the NASA Science Internet, a multiprotocol network currently supporting both DECnet and TCP/IP protocols. NSI utilizes state-of-the-art network technology to meet its customers' requirements. THe NASA Science Internet interconnects with other national networks including the National Science Foundation's NSFNET, the Department of Energy's ESnet, and the Department of Defense's MILNET. NSI also has international connections to Japan, Australia, New Zealand, Chile, and several European countries. NSI cooperates with other government agencies as well as academic and commercial organizations to implement networking technologies which foster interoperability, improve reliability and performance, increase security and control, and expedite migration to the OSI protocols.

A chaotic cryptosystem for images based on Henon and Arnold cat map.

PubMed

Soleymani, Ali; Nordin, Md Jan; Sundararajan, Elankovan

2014-01-01

The rapid evolution of imaging and communication technologies has transformed images into a widespread data type. Different types of data, such as personal medical information, official correspondence, or governmental and military documents, are saved and transmitted in the form of images over public networks. Hence, a fast and secure cryptosystem is needed for high-resolution images. In this paper, a novel encryption scheme is presented for securing images based on Arnold cat and Henon chaotic maps. The scheme uses Arnold cat map for bit- and pixel-level permutations on plain and secret images, while Henon map creates secret images and specific parameters for the permutations. Both the encryption and decryption processes are explained, formulated, and graphically presented. The results of security analysis of five different images demonstrate the strength of the proposed cryptosystem against statistical, brute force and differential attacks. The evaluated running time for both encryption and decryption processes guarantee that the cryptosystem can work effectively in real-time applications.

A Chaotic Cryptosystem for Images Based on Henon and Arnold Cat Map

PubMed Central

Sundararajan, Elankovan

2014-01-01

The rapid evolution of imaging and communication technologies has transformed images into a widespread data type. Different types of data, such as personal medical information, official correspondence, or governmental and military documents, are saved and transmitted in the form of images over public networks. Hence, a fast and secure cryptosystem is needed for high-resolution images. In this paper, a novel encryption scheme is presented for securing images based on Arnold cat and Henon chaotic maps. The scheme uses Arnold cat map for bit- and pixel-level permutations on plain and secret images, while Henon map creates secret images and specific parameters for the permutations. Both the encryption and decryption processes are explained, formulated, and graphically presented. The results of security analysis of five different images demonstrate the strength of the proposed cryptosystem against statistical, brute force and differential attacks. The evaluated running time for both encryption and decryption processes guarantee that the cryptosystem can work effectively in real-time applications. PMID:25258724

ARC-2008-ACD08-0214-004

NASA Image and Video Library

2008-09-24

Director's Colloquium: Ruslan Belikov, Ames Astrophysicist presents 'Imaging other Earths and High Contrast Coronagraphy at Ames abstract: Exoplanet detection over the past decade - Audio available through Ames Library

High-risk cocktails and high-risk sex: examining the relation between alcohol mixed with energy drink consumption, sexual behavior, and drug use in college students.

PubMed

Snipes, Daniel J; Benotsch, Eric G

2013-01-01

Alcohol mixed with energy drink (AmED) consumption has garnered considerable attention in the literature in recent years. Drinking AmED beverages has been associated with a host of negative outcomes. The present study sought to examine associations between AmED consumption and high-risk sexual behaviors in a sample of young adults. Participants (N=704; 59.9% female) completed an online survey assessing AmED consumption, other drug use, and sexual behavior. A total of 19.4% of the entire sample (and 28.8% of those who reported using alcohol) reported consuming AmED. Participants who reported consuming AmED were significantly more likely to report marijuana, cocaine, and ecstasy use. Those who reported consuming AmED also had increased odds of engaging in high-risk sexual behaviors, including unprotected sex, sex while under the influence of drugs, and sex after having too much to drink. Relationships between AmED consumption and sexual behavior remained significant after accounting for the influence of demographic factors and other substance use. Results add to the literature documenting negative consequences for AmED consumers, which may include alcohol dependence, binge drinking, and the potential for sexually transmitted infections via high-risk sexual behavior. Copyright © 2012 Elsevier Ltd. All rights reserved.

The Ames Power Monitoring System

NASA Technical Reports Server (NTRS)

Osetinsky, Leonid; Wang, David

2003-01-01

The Ames Power Monitoring System (APMS) is a centralized system of power meters, computer hardware, and specialpurpose software that collects and stores electrical power data by various facilities at Ames Research Center (ARC). This system is needed because of the large and varying nature of the overall ARC power demand, which has been observed to range from 20 to 200 MW. Large portions of peak demand can be attributed to only three wind tunnels (60, 180, and 100 MW, respectively). The APMS helps ARC avoid or minimize costly demand charges by enabling wind-tunnel operators, test engineers, and the power manager to monitor total demand for center in real time. These persons receive the information they need to manage and schedule energy-intensive research in advance and to adjust loads in real time to ensure that the overall maximum allowable demand is not exceeded. The APMS (see figure) includes a server computer running the Windows NT operating system and can, in principle, include an unlimited number of power meters and client computers. As configured at the time of reporting the information for this article, the APMS includes more than 40 power meters monitoring all the major research facilities, plus 15 Windows-based client personal computers that display real-time and historical data to users via graphical user interfaces (GUIs). The power meters and client computers communicate with the server using Transmission Control Protocol/Internet Protocol (TCP/IP) on Ethernet networks, variously, through dedicated fiber-optic cables or through the pre-existing ARC local-area network (ARCLAN). The APMS has enabled ARC to achieve significant savings ($1.2 million in 2001) in the cost of power and electric energy by helping personnel to maintain total demand below monthly allowable levels, to manage the overall power factor to avoid low power factor penalties, and to use historical system data to identify opportunities for additional energy savings. The APMS also provides power engineers and electricians with the information they need to plan modifications in advance and perform day-to-day maintenance of the ARC electric-power distribution system.

ARC-1968-A-41727-6-4

NASA Image and Video Library

1968-10-24

Management process invaded Ames as the Center shifted from NACA to NASA oversight. Ames constructed a review room in its headquarters building where, in the graphical style that prevailed in the 1960's, Ames leadership could review progress against schedule, budget and performance measures. Shown, in October 1965 is Merrill Mead chief of Ames' program and resources office. (for H Julian Allen Retirement album)

ARC-1969-AC-31031

NASA Image and Video Library

1963-06-11

Ames aerodynamicists tested a wide variety of VTOL aircraft and helicopters during the 1960's. Here the Hiller rotorcycle YROE-1, made by Hiller Helicopter in nearby PaloAlto, California, hovers in front of the Ames Hangar. (4020, 4021, 4024) Published in NASA SP Flight Research at Ames: 57 Years of Development and Validation of Aeronautical Technology and Ames 60yr History Atmosphere of Freedom.

A UK student survey investigating the effects of consuming alcohol mixed with energy drinks on overall alcohol consumption and alcohol-related negative consequences.

PubMed

Johnson, Sean J; Alford, Chris; Stewart, Karina; Verster, Joris C

2016-12-01

Previous research reported positive associations between alcohol mixed with energy drink (AMED) consumption and overall alcohol consumption. However, results were largely based on between-subjects comparisons comparing AMED consumers with alcohol-only (AO) consumers, and therefore cannot sufficiently control for differences in personal characteristics between these groups. In order to determine whether AMED consumers drink more alcohol on occasions they consume AMED compared to those when they drink AO additional within-subjects comparisons are required. Therefore, this UK student survey assessed both alcohol consumption and alcohol-related negative consequences when consumed alone and when mixed with energy drinks, using a within-subject design. A total of 1873 students completed the survey, including 732 who consumed AMED. It was found that AMED consumers drank significantly less alcohol when they consumed AMED compared to when they drank AO (p < 0.001). In line with reduced alcohol consumption significantly fewer negative alcohol-related consequences were reported on AMED occasions compared to AO occasions (p < 0.001). These findings suggest that mixing alcohol with energy drinks does not increase total alcohol consumption or alcohol-related negative consequences.

Hypothalamic hypocretinergic/orexinergic neurons projecting to the oral pontine rapid eye movement sleep inducing site in the cat.

PubMed

García-García, Berta; Reinoso-Suárez, Fernando; Rodrigo-Angulo, Margarita L

2013-05-01

The cat ventral oral pontine reticular nucleus (vRPO) is responsible for the generation and maintenance of rapid eye movement (REM) sleep. Hypothalamic neurons containing the peptide hypocretin-1 (also called orexin-A) which will be herewith defined as orexinergic (Orx) neurons, occupy a pre-eminent place in the integration and stabilization of arousal networks as well as in the physiopathology of narcolepsy/cataplexy. In the previous investigations, low-volume and dose microinjections of hypocretin-1 in cat vRPO produced a specific and significant suppression of REM sleep. The aim of this study is to map the hypothalamic Orx neurons that project to the vRPO and suppress REM sleep generation in the cat. Five adult cats received microinjections of the retrograde tracer cholera toxin (CTb) into the vRPO. Brains were processed employing both CTb staining and antiorexin-A immunocytochemistry techniques. A large number of double-labeled neurons (Orx-CTb) intermingled with the single CTb-positive and single Orx neurons were detected in the ipsilateral lateral, perifornical, dorsal, anterior, perimammillothalamic, and posterior hypothalamic areas but were very scarce in the paraventricular, dorsomedial, ventromedial, and periventricular hypothalamic nuclei. A considerable number of double-labeled neurons were also observed in both the dorsal and the lateral hypothalamic areas in the contralateral hypothalamus. Our results suggest that the widely distributed Orx neuronal hypothalamic groups could physiologically inhibit REM sleep generation in vRPO. Copyright © 2013 Wiley Periodicals, Inc.

Tiger Team Assessment of the Ames Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-03-01

This report documents the Tiger Assessment of the Ames Laboratory (Ames), located in Ames, Iowa. Ames is operated for the US Department of Energy (DOE) by Iowa State University. The assessment was conducted from February 10 to March 5, 1992, under the auspices of the Office of Special Projects, Office of the Assistant Secretary of Environment, Safety and Health, Headquarters, DOE. The assessment was comprehensive, encompassing Environment, Safety, and Health (ES H) disciplines; management practices; and contractor and DOE self-assessments. Compliance with applicable Federal, State of Iowa, and local regulations; applicable DOE Orders; best management practices; and internal requirements atmore » Ames Laboratory were assessed. In addition, an evaluation of the adequacy and effectiveness of DOE and the site contractor's management of ES H/quality assurance program was conducted.« less

ARC-2008-ACD08-0205-069

NASA Image and Video Library

2008-09-16

NASA's 50th Anniversay year. Panel discussion with four of NASA AMES's past center directors on how their tenure effected Ames and NASA. On the projects they pushed for and/or pushed forward and the culture of the center and the agency and how that worked for or against Ames, as well as major contributions of the time made by Ames Research Center. Panel L-R; Hans Mark, Sy Syvertson, Dale Compton, Scott Hubbard and Pete Worden, present director. (Past Directors served for periods from 1969 thru 2006) Sy Syverson posses with his portrait hanging in the hall of NASA Ames Administration Building N-200.

Ames life science telescience testbed evaluation

NASA Technical Reports Server (NTRS)

Haines, Richard F.; Johnson, Vicki; Vogelsong, Kristofer H.; Froloff, Walt

1989-01-01

Eight surrogate spaceflight mission specialists participated in a real-time evaluation of remote coaching using the Ames Life Science Telescience Testbed facility. This facility consisted of three remotely located nodes: (1) a prototype Space Station glovebox; (2) a ground control station; and (3) a principal investigator's (PI) work area. The major objective of this project was to evaluate the effectiveness of telescience techniques and hardware to support three realistic remote coaching science procedures: plant seed germinator charging, plant sample acquisition and preservation, and remote plant observation with ground coaching. Each scenario was performed by a subject acting as flight mission specialist, interacting with a payload operations manager and a principal investigator expert. All three groups were physically isolated from each other yet linked by duplex audio and color video communication channels and networked computer workstations. Workload ratings were made by the flight and ground crewpersons immediately after completing their assigned tasks. Time to complete each scientific procedural step was recorded automatically. Two expert observers also made performance ratings and various error assessments. The results are presented and discussed.

Real-Time 3D Visualization

NASA Technical Reports Server (NTRS)

1997-01-01

Butler Hine, former director of the Intelligent Mechanism Group (IMG) at Ames Research Center, and five others partnered to start Fourth Planet, Inc., a visualization company that specializes in the intuitive visual representation of dynamic, real-time data over the Internet and Intranet. Over a five-year period, the then NASA researchers performed ten robotic field missions in harsh climes to mimic the end- to-end operations of automated vehicles trekking across another world under control from Earth. The core software technology for these missions was the Virtual Environment Vehicle Interface (VEVI). Fourth Planet has released VEVI4, the fourth generation of the VEVI software, and NetVision. VEVI4 is a cutting-edge computer graphics simulation and remote control applications tool. The NetVision package allows large companies to view and analyze in virtual 3D space such things as the health or performance of their computer network or locate a trouble spot on an electric power grid. Other products are forthcoming. Fourth Planet is currently part of the NASA/Ames Technology Commercialization Center, a business incubator for start-up companies.

Predicting the digestible energy of corn determined with growing swine from nutrient composition and cross-species measurements.

PubMed

Smith, B; Hassen, A; Hinds, M; Rice, D; Jones, D; Sauber, T; Iiams, C; Sevenich, D; Allen, R; Owens, F; McNaughton, J; Parsons, C

2015-03-01

The DE values of corn grain for pigs will differ among corn sources. More accurate prediction of DE may improve diet formulation and reduce diet cost. Corn grain sources ( = 83) were assayed with growing swine (20 kg) in DE experiments with total collection of feces, with 3-wk-old broiler chick in nitrogen-corrected apparent ME (AME) trials and with cecectomized adult roosters in nitrogen-corrected true ME (TME) studies. Additional AME data for the corn grain source set was generated based on an existing near-infrared transmittance prediction model (near-infrared transmittance-predicted AME [NIT-AME]). Corn source nutrient composition was determined by wet chemistry methods. These data were then used to 1) test the accuracy of predicting swine DE of individual corn sources based on available literature equations and nutrient composition and 2) develop models for predicting DE of sources from nutrient composition and the cross-species information gathered above (AME, NIT-AME, and TME). The overall measured DE, AME, NIT-AME, and TME values were 4,105 ± 11, 4,006 ± 10, 4,004 ± 10, and 4,086 ± 12 kcal/kg DM, respectively. Prediction models were developed using 80% of the corn grain sources; the remaining 20% was reserved for validation of the developed prediction equation. Literature equations based on nutrient composition proved imprecise for predicting corn DE; the root mean square error of prediction ranged from 105 to 331 kcal/kg, an equivalent of 2.6 to 8.8% error. Yet among the corn composition traits, 4-variable models developed in the current study provided adequate prediction of DE (model ranging from 0.76 to 0.79 and root mean square error [RMSE] of 50 kcal/kg). When prediction equations were tested using the validation set, these models had a 1 to 1.2% error of prediction. Simple linear equations from AME, NIT-AME, or TME provided an accurate prediction of DE for individual sources ( ranged from 0.65 to 0.73 and RMSE ranged from 50 to 61 kcal/kg). Percentage error of prediction based on the validation data set was greater (1.4%) for the TME model than for the NIT-AME or AME models (1 and 1.2%, respectively), indicating that swine DE values could be accurately predicted by using AME or NIT-AME. In conclusion, regression equations developed from broiler measurements or from analyzed nutrient composition proved adequate to reliably predict the DE of commercially available corn hybrids for growing pigs.

NASA Ames Research Center: An Overview

NASA Technical Reports Server (NTRS)

Tu, Eugene; Yan, Jerry Chi Yiu

2017-01-01

This overview of NASA Ames Research Center is intended to give the target audience of university students a general understanding of the mission, core competencies, and research goals of NASA and Ames.

ARC-2008-ACD08-0260-007

NASA Image and Video Library

2008-11-05

K-10 'Red' planetary rover in the Nasa Ames Marscape: operations tests at Marscape (Ames Mars Yard) with remote operations from Ames Future Flight Centeral (FFC) Simulator with Susan Y. Lee observing.

Are energy drinks unique mixers in terms of their effects on alcohol consumption and negative alcohol-related consequences?

PubMed

Johnson, Sean J; Alford, Chris; Stewart, Karina; Verster, Joris C

2018-01-01

Previous research has suggested that consuming alcohol mixed with energy drinks (AMED) increases overall alcohol consumption. However, there is limited research examining whether energy drinks are unique in their effects when mixed with alcohol, when compared with alcohol mixed with other caffeinated mixers (AOCM). Therefore, the aim of this survey was to investigate alcohol consumption on AMED occasions, to that on other occasions when the same individuals consumed AOCM or alcohol only (AO). A UK-wide online student survey collected data on the frequency of alcohol consumption and quantity consumed, as well as the number of negative alcohol-related consequences reported on AO, AMED and AOCM occasions (N=250). Within-subjects analysis revealed that there were no significant differences in the number of alcoholic drinks consumed on a standard and a heavy drinking session between AMED and AOCM drinking occasions. However, the number of standard mixers typically consumed was significantly lower on AMED occasions compared with AOCM occasions. In addition, when consuming AMED, students reported significantly fewer days consuming 5 or more alcohol drinks, fewer days mixing drinks, and fewer days being drunk, compared with when consuming AOCM. There were no significant differences in the number of reported negative alcohol-related consequences on AMED occasions to AOCM occasions. Of importance, alcohol consumption and negative alcohol-related consequences were significantly less on both AMED and AOCM occasions compared with AO occasions. The findings that heavy alcohol consumption occurs significantly less often on AMED occasions compared with AOCM occasions is in opposition to some earlier claims implying that greatest alcohol consumption occurs with AMED. The overall greatest alcohol consumption and associated negative consequences were clearly associated with AO occasions. Negative consequences for AMED and AOCM drinking occasions were similar, suggesting that energy drink was comparable with AOCM in this regard.

Evaluation of the sensitivity and specificity of in vivo erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogens.

PubMed

Morita, Takeshi; Hamada, Shuichi; Masumura, Kenichi; Wakata, Akihiro; Maniwa, Jiro; Takasawa, Hironao; Yasunaga, Katsuaki; Hashizume, Tsuneo; Honma, Masamitsu

2016-05-01

Sensitivity and/or specificity of the in vivo erythrocyte micronucleus (MN) and transgenic rodent mutation (TGR) tests to detect rodent carcinogens and non-carcinogens were investigated. The Carcinogenicity and Genotoxicity eXperience (CGX) dataset created by Kirkland et al. was used for the carcinogenicity and in vitro genotoxicity data, i.e., Ames and chromosome aberration (CA) tests. Broad literature surveys were conducted to gather in vivo MN or TGR test data to add to the CGX dataset. Genotoxicity data in vitro were also updated slightly. Data on 379 chemicals (293 carcinogens and 86 non-carcinogens) were available for the in vivo MN test; sensitivity, specificity or concordances were calculated as 41.0%, 60.5% or 45.4%, respectively. For the TGR test, data on 80 chemicals (76 carcinogens and 4 non-carcinogens) were available; sensitivity was calculated as 72.4%. Based on the recent guidance on genotoxicity testing strategies, performance (sensitivity/specificity) of the following combinations was calculated; Ames+in vivo MN (68.7%/45.3%), Ames+TGR (83.8%/not calculated (nc)), Ames+in vitro CA+in vivo MN (80.8%/21.3%), Ames+in vitro CA+TGR (89.1%/nc), Ames+in vivo MN+TGR (87.5%/nc), Ames+in vitro CA+in vivo MN+TGR (89.3%/nc). Relatively good balance in performance was shown by the Ames+in vivo MN in comparison with Ames+in vitro CA (74.3%/37.5%). Ames+TGR and Ames+in vivo MN+TGR gave even higher sensitivity, but the specificity could not be calculated (too few TGR data on non-carcinogens). This indicates that in vivo MN and TGR tests are both useful as in vivo tests to detect rodent carcinogens. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Flexion Reflex Can Interrupt and Reset the Swimming Rhythm.

PubMed

Elson, Matthew S; Berkowitz, Ari

2016-03-02

The spinal cord can generate the hip flexor nerve activity underlying leg withdrawal (flexion reflex) and the rhythmic, alternating hip flexor and extensor activities underlying locomotion and scratching, even in the absence of brain inputs and movement-related sensory feedback. It has been hypothesized that a common set of spinal interneurons mediates flexion reflex and the flexion components of locomotion and scratching. Leg cutaneous stimuli that evoke flexion reflex can alter the timing of (i.e., reset) cat walking and turtle scratching rhythms; in addition, reflex responses to leg cutaneous stimuli can be modified during cat and human walking and turtle scratching. Both of these effects depend on the phase (flexion or extension) of the rhythm in which the stimuli occur. However, similar interactions between leg flexion reflex and swimming have not been reported. We show here that a tap to the foot interrupted and reset the rhythm of forward swimming in spinal, immobilized turtles if the tap occurred during the swim hip extensor phase. In addition, the hip flexor nerve response to an electrical foot stimulus was reduced or eliminated during the swim hip extensor phase. These two phase-dependent effects of flexion reflex on the swim rhythm and vice versa together demonstrate that the flexion reflex spinal circuit shares key components with or has strong interactions with the swimming spinal network, as has been shown previously for cat walking and turtle scratching. Therefore, leg flexion reflex circuits likely share key spinal interneurons with locomotion and scratching networks across limbed vertebrates generally. The spinal cord can generate leg withdrawal (flexion reflex), locomotion, and scratching in limbed vertebrates. It has been hypothesized that there is a common set of spinal cord neurons that produce hip flexion during flexion reflex, locomotion, and scratching based on evidence from studies of cat and human walking and turtle scratching. We show here that flexion reflex and swimming also share key spinal cord components based on evidence from turtles. Foot stimulation can reset the timing of the swimming rhythm and the response to each foot stimulation can itself be altered by the swim rhythm. Collectively, these studies suggest that spinal cord neuronal networks underlying flexion reflex, multiple forms of locomotion, and scratching share key components. Copyright © 2016 the authors 0270-6474/16/362819-08$15.00/0.

Combined use of alcohol and energy drinks: Dose relationship with self-reported physiological stimulation and sedation side effects.

PubMed

Droste, Nicolas; Peacock, Amy; Bruno, Raimondo; Pennay, Amy; Zinkiewicz, Lucy; Lubman, Dan I; Miller, Peter

2017-08-01

Negative physiological stimulation and sedation side effects are experienced by a significant proportion of consumers who consume alcohol mixed with energy drinks (AmED). Few studies have compared the frequency of side effects between sessions of AmED and sessions of alcohol only within-subject, and none have explored a dose relationship. Explore the occurrence of self-reported physiological stimulant and sedative side effects between sessions of AmED and alcohol only, and at varying ED dosage levels within AmED sessions. A convenience sample of 2953 residents of New South Wales, Australia completed an online survey. N=731 AmED users reported daily caffeine intake, typical alcohol and AmED consumption, and past 12-month experience of physiological stimulation and sedation side effects during AmED and alcohol only sessions. Within-subject analyses compared occurrence of side effects between session types. Hierarchical binary logistic regression analyses explored the association of ED dose during AmED sessions with the experience of physiological side effects. There were greater odds of most stimulant side effects, and lower odds of sedation side effects, during AmED sessions compared to alcohol only sessions. Compared to one ED, consumption of three or more EDs was significantly associated with the majority of both stimulant and alcohol intoxication side effects after controlling for demographics and consumption covariates. AmED is associated with perceived changes in physiological stimulant and sedation side effects of alcohol. Experience of side effects is positively associated with ED dosage. Future research should account for varying ED dosage, and reflect real world consumption levels. Copyright © 2017 Elsevier Ltd. All rights reserved.

Environmental contexts of combined alcohol and energy drink use: Associations with intoxication in licensed venues.

PubMed

Droste, Nicolas; Miller, Peter; Pennay, Amy; Zinkiewicz, Lucy; Lubman, Dan I

2016-10-01

Environmental factors inside licensed venues have been found to influence the intoxication levels and consumption practices of patrons. The consumption of alcohol mixed with energy drinks (AmED) occurs primarily at or prior to attending licensed venues, however there is a lack of in situ research investigating AmED use in these contexts. Given that AmED use has been linked with increased alcohol consumption, intoxication, illicit substance use, and risk taking behaviours, this paper explores the environmental correlates and levels of intoxication associated with AmED use in licensed venues. Structured observations were undertaken in five Australian cities on Friday and Saturday nights. Covert teams spent 4-5h in venues and recorded hourly observations on patron, venue, and staff characteristics, alcohol, illicit drug and AmED consumption patterns and intoxication levels. 898 hourly observations were recorded across 68 venues. All but one venue served energy drinks, and patron AmED use was observed during 34.9% of hourly records. AmED use was more prevalent after 12am and in nightclub venues compared to bars and pubs, and was positively associated with high intoxication levels, illicit drug use, and younger crowds. After controlling for environmental factors (i.e. venue crowding, service practices, venue characteristics, patron demographics and behaviour) AmED use did not predict high intoxication at a venue level in multivariable models. AmED consumption is ubiquitous in the licensed venues of Australian night-time entertainment districts, particularly busy nightclub venues where intoxication and risky consumption are heightened. However, AmED use was not associated with high patron intoxication when environmental factors were considered. Copyright © 2016 Elsevier B.V. All rights reserved.

Combined alcohol and energy drink use: hedonistic motives, adenosine, and alcohol dependence.

PubMed

Marczinski, Cecile A

2014-07-01

Consumption of alcohol mixed with energy drinks (AmED) has been associated with both short- and long-term risks beyond those observed with alcohol alone. AmED use has been associated with heavy episodic (binge) drinking, risky behaviors, and risk of alcohol dependence. Laboratory research has demonstrated that AmED beverages lead to greater motivation to drink versus the same amount of alcohol consumed alone. However, the reason consumers find AmED beverages particularly appealing has been unclear. A recent report by Droste and colleagues (Alcohol Clin Exp Res 2014; 38:2087-2095) is the first study to investigate motivations related to AmED consumption and to determine which motives predict AmED consumption patterns, experience of drinking-related harms, and risk of alcohol dependence. The findings of this study significantly enhance our understanding of why AmED consumption is related to the risk of alcohol dependence and change our understanding of why consumers choose AmED beverages. The authors report that hedonistic motives strongly predicted AmED use and the harms associated with use. While intoxication-reduction motives predicted self-reported accidents and injuries, these motives did not predict AmED consumption patterns and risk of dependence. The risk of alcohol dependence may arise from repeated experiences when drinking alcohol is more pleasurable when energy drinks are consumed with the alcohol. This commentary will focus on why energy drinks might increase the rewarding properties of alcohol in social drinkers. In addition, discussion is provided explaining why more research on the neurotransmitter, adenosine, may actually inform us about the mechanisms contributing to the development of alcohol dependence. Copyright © 2014 by the Research Society on Alcoholism.

Alcohol mixed with energy drink use among u.s. 12th-grade students: prevalence, correlates, and associations with unsafe driving.

PubMed

Martz, Meghan E; Patrick, Megan E; Schulenberg, John E

2015-05-01

The consumption of alcohol mixed with energy drinks (AmED) is a risky drinking behavior, most commonly studied using college samples. We know little about rates of AmED use and its associations with other risk behaviors, including unsafe driving, among high school students. This study examined the prevalence and correlates of AmED use among high school seniors in the United States. Nationally representative analytic samples included 6,498 12th-grade students who completed Monitoring the Future surveys in 2012 and 2013. Focal measures included AmED use, sociodemographic characteristics, academic and social factors, other substance use, and unsafe driving (i.e., tickets/warnings and accidents) after alcohol consumption. Approximately one in four students (24.8%) reported AmED use during the past 12 months. Rates of AmED use were highest among males and white students. Using multivariable logistic regression models controlling for sociodemographic characteristics, results indicate that students who cut class, spent more evenings out for fun and recreation, and reported binge drinking, marijuana use, and illicit drug use had a greater likelihood of AmED use. AmED use was also associated with greater odds of alcohol-related unsafe driving, even after controlling for sociodemographic, academic, and social factors and other substance use. AmED use among 12th-grade students is common and associated with certain sociodemographic, academic, social, and substance use factors. AmED use is also related to alcohol-related unsafe driving, which is a serious public health concern. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Intraspinal Microstimulation Produces Over-ground Walking in Anesthetized Cats

PubMed Central

Holinski, B.J.; Mazurek, K.A.; Everaert, D.G.; Toossi, A.; Lucas-Osma, A.M.; Troyk, P.; Etienne-Cummings, R.; Stein, R.B.; Mushahwar, V.K.

2016-01-01

Objective Spinal cord injury causes a drastic loss of motor, sensory and autonomic function. The goal of this project was to investigate the use of intraspinal microstimulation (ISMS) for producing long distances of walking over ground. ISMS is an electrical stimulation method developed for restoring motor function by activating spinal networks below the level of an injury. It produces movements of the legs by stimulating the ventral horn of the lumbar enlargement using fine penetrating electrodes (≤ 50µm diameter). Approach In each of five adult cats (4.2–5.5kg), ISMS was applied through 16 electrodes implanted with tips targeting lamina IX in the ventral horn bilaterally. A desktop system implemented a physiologically-based control strategy that delivered different stimulation patterns through groups of electrodes to evoke walking movements with appropriate limb kinematics and forces corresponding to swing and stance. Each cat walked over an instrumented 2.9m walkway and limb kinematics and forces were recorded. Main Results Both propulsive and supportive forces were required for over-ground walking. Cumulative walking distances ranging from 609m to 835m (longest tested) were achieved in three animals. In these three cats, the mean peak supportive force was 3.5±0.6N corresponding to full-weight-support of the hind legs, while the angular range of the hip, knee, and ankle joints were 23.1±2.0°, 29.1±0.2°, and 60.3±5.2°, respectively. To further demonstrate the viability of ISMS for future clinical use, a prototype implantable module was successfully implemented in a subset of trials and produced comparable walking performance. Significance By activating inherent locomotor networks within the lumbosacral spinal cord, ISMS was capable of producing bilaterally coordinated and functional over-ground walking with current amplitudes <100 µA. These exciting results suggest that ISMS may be an effective intervention for restoring functional walking after spinal cord injury. PMID:27619069

A non-randomized [corrected] controlled trial of the active music engagement (AME) intervention on children with cancer.

PubMed

Robb, Sheri L; Clair, Alicia A; Watanabe, Masayo; Monahan, Patrick O; Azzouz, Faouzi; Stouffer, Janice W; Ebberts, Allison; Darsie, Emily; Whitmer, Courtney; Walker, Joey; Nelson, Kirsten; Hanson-Abromeit, Deanna; Lane, Deforia; Hannan, Ann

2008-07-01

Coping theorists argue that environmental factors affect how children perceive and respond to stressful events such as cancer. However, few studies have investigated how particular interventions can change coping behaviors. The active music engagement (AME) intervention was designed to counter stressful qualities of the in-patient hospital environment by introducing three forms of environmental support. The purpose of this multi-site randomized controlled trial was to determine the efficacy of the AME intervention on three coping-related behaviors (i.e. positive facial affect, active engagement, and initiation). Eighty-three participants, ages 4-7, were randomly assigned to one of three conditions: AME (n = 27), music listening (ML; n = 28), or audio storybooks (ASB; n = 28). Conditions were videotaped to facilitate behavioral data collection using time-sampling procedures. After adjusting for baseline differences, repeated measure analyses indicated that AME participants had a significantly higher frequency of coping-related behaviors compared with ML or ASB. Positive facial affect and active engagement were significantly higher during AME compared with ML and ASB (p<0.0001). Initiation was significantly higher during AME than ASB (p<0.05). This study supports the use of the AME intervention to encourage coping-related behaviors in hospitalized children aged 4-7 receiving cancer treatment. (c) 2007 John Wiley & Sons, Ltd.

The Influence of the Phonological Neighborhood Clustering Coefficient on Spoken Word Recognition

ERIC Educational Resources Information Center

Chan, Kit Ying; Vitevitch, Michael S.

2009-01-01

Clustering coefficient--a measure derived from the new science of networks--refers to the proportion of phonological neighbors of a target word that are also neighbors of each other. Consider the words "bat", "hat", and "can", all of which are neighbors of the word "cat"; the words "bat" and…

A Mapping of the Federal Financial Institutions Examination Council (FFIEC) Cybersecurity Assessment Tool (CAT) to the Cyber Resilience Review (CRR)

DTIC Science & Technology

2016-10-01

rooted detection). (*N/A if mobile devices are not used.) Gap Mobile devices connecting to the corporate network for storing and accessing...actions, resources, and time parameters. SCM:G1.Q1 The corporate disaster recovery, business continuity, and crisis management plans have

Earth Observations taken by the Expedition 17 Crew

NASA Image and Video Library

2008-05-03

ISS017-E-006184 (3 May 2008) --- NASA Ames Research Center, Moffett Field, CA is featured in this image photographed by an Expedition 17 crewmember on the International Space Station. This view illustrates the diverse built environment surrounding NASA's Ames Research Center, or ARC located at the southernmost end of the San Francisco Bay. Founded in 1939 as an aircraft research laboratory, Ames became a NASA facility in 1958. Its original aircraft research focus was enhanced by the adjacent Moffett Field -- an active Naval Air Station until 1994 and original home of the Navy dirigible U.S.S. Macon. The large hanger for docking the U.S.S. Macon is still present at Moffett Field, and is visible in this image (center). Today, NASA ARC includes the former Naval Air Station, and continues its focus on aeronautics in addition to nanotechnology, information technology, fundamental space biology, biotechnology, thermal protection systems, and human factors research. Land use and land cover in the southern San Francisco Bay area is a diverse mix of industrial, institutional, and residential patterns. Industrial lots -- characterized by lack of green vegetation and large buildings with highly reflective white rooftops -- border NASA ARC to the west, east, and south. The city of Mountain View directly to the south appears as a dense gray-brown network of streets and residential properties with interspersed green parks. The northern boundary of NASA ARC consists of former salt ponds in the process of being returned to tidal wetlands (right). Drainage channels that predate the salt pond levees are visible at right.

ARC-2006-ACD06-0230-018

NASA Image and Video Library

2006-12-15

Kick-off event for Google NASA collaboration (held in the Ames Exploration Center 943A) with Chris Kemp, Ames Business Development (L) Ames Center Director Pete Worden (M) and Dan Clancy, Director of engineering Google (R)

ARC-2006-ACD06-0230-019

NASA Image and Video Library

2006-12-15

Kick-off event for Google NASA collaboration (held in the Ames Exploration Center 943A) with Chris Kemp, Ames Business Development (L) Ames Center Director Pete Worden (M) and Dan Clancy, Director of engineering Google (R)

ACD16-0001-019

NASA Image and Video Library

2016-01-06

Senior executives from the Renault-Nissan Alliance visited Ames meet with Ames management and gather for a Autonomous Drive demo. Shown here left to right is Terry Fong, Ames Research Center and Jose Munoz, Chairman, Nissan North America.

Energy Drinks Mixed with Alcohol: What are the Risks?

PubMed Central

Marczinski, Cecile A.; Fillmore, Mark T.

2014-01-01

Energy drinks are popular beverages that typically include high levels of caffeine and other ingredients such as taurine, or caffeine-containing herbs, such as guarana. While energy drinks are often consumed alone, they are also frequently used as mixers for alcoholic beverages. This review summarizes what is known about the scope of use of alcohol mixed with energy drinks (AmED), the risks associated with AmED, and the objective laboratory data examining how AmED differs from alcohol alone. The weight of the evidence reveals that AmED beverages are riskier than alcohol alone and constitute a public health concern. AmED beverage consumption is frequent, especially in young and underage drinkers. AmED use is associated with elevated rates of binge drinking, impaired driving, risky sexual behavior, and risk of alcohol dependence when compared with alcohol alone. Laboratory research (human and animal) has demonstrated that AmED beverages lead to altered subjective states including decreased perceived intoxication, enhanced stimulation, and increased desire to drink/increased drinking compared to alcohol alone. Possible underlying mechanisms explaining these observations are highlighted. PMID:25293549

Optical information processing for NASA's space exploration

NASA Technical Reports Server (NTRS)

Chao, Tien-Hsin; Ochoa, Ellen; Juday, Richard

1990-01-01

The development status of optical processing techniques under development at NASA-JPL, NASA-Ames, and NASA-Johnson, is evaluated with a view to their potential applications in future NASA planetary exploration missions. It is projected that such optical processing systems can yield major reductions in mass, volume, and power requirements relative to exclusively electronic systems of comparable processing capabilities. Attention is given to high-order neural networks for distortion-invariant classification and pattern recognition, multispectral imaging using an acoustooptic tunable filter, and an optical matrix processor for control problems.

The path to producing pharmaceuticals from natural products uncovered by academia-from the perspective of a science coordinator.

PubMed

Fujie, Akihiko

2017-01-01

To actualize the invention of all-Japanese medicines, the Department of Innovative Drug Discovery and Development (iD3) in the Japan Agency for Medical Research and Development (AMED) serves as the headquarters for the Drug Discovery Support Network. iD3 assists with creating research strategies for the seeds of medicines discovered by academia and provides technological support, intellectual property management, and aid for applying the seeds through industry-led efforts. In this review, from the perspective of a science coordinator, I will describe the current activities of the drug discovery support network and iD3 as well as the challenges and future developments of pharmaceutical research and development using the natural product drug discovery method.

Workstations take over conceptual design

NASA Technical Reports Server (NTRS)

Kidwell, George H.

1987-01-01

Workstations provide sufficient computing memory and speed for early evaluations of aircraft design alternatives to identify those worthy of further study. It is recommended that the programming of such machines permit integrated calculations of the configuration and performance analysis of new concepts, along with the capability of changing up to 100 variables at a time and swiftly viewing the results. Computations can be augmented through links to mainframes and supercomputers. Programming, particularly debugging operations, are enhanced by the capability of working with one program line at a time and having available on-screen error indices. Workstation networks permit on-line communication among users and with persons and computers outside the facility. Application of the capabilities is illustrated through a description of NASA-Ames design efforts for an oblique wing for a jet performed on a MicroVAX network.

ARC-2010-ACD10-0015-109

NASA Image and Video Library

2010-01-28

Ames 70th Anniversary Turn Back the Clock Day with antique Class Cars and Classic Car parade around the center. Lewis Braxton III, Ames Deputy Center Director and Jack Boyd, Ames Historian lead the parade in Lew's Mustang.

Who uses alcohol mixed with energy drinks? Characteristics of college student users.

PubMed

Patrick, Megan E; Macuada, Carlos; Maggs, Jennifer L

2016-01-01

To examine characteristics associated with alcohol mixed with energy drink (AmED) use in a sample of college students. College students (N = 614, 53% female) in their second year of college participated during the fall of 2008. Students completed a cross-sectional survey with questions regarding AmED use. AmED use in the last 30 days was reported by 27% of participants. Logistic regression analyses found that risk factors for AmED included participating in a fraternity/sorority; participating in athletics; living off-campus; having greater fun/social, relax, and image motives for alcohol consumption; and binge drinking. Protective factors included early morning classes, honors program participation, and greater physical/behavioral motives for not drinking. Risk factors for AmED use can identify college students most likely to consume AmEDs and thereby inform screening and intervention efforts to reduce negative AmED-related consequences.

Proper expression of metabolizable energy in avian energetics

USGS Publications Warehouse

Miller, M.R.; Reinecke, K.J.

1984-01-01

We review metabolizable energy (ME) concepts and present evidence suggesting that the form of ME used for analyses of avian energetics can affect interpretation of results. Apparent ME (AME) is the most widely used measure of food energy available to birds. True ME(TME) differs from AME in recognizing fecal and urinary energy of nonfood origin as metabolized energy. Only AME values obtained from test birds fed at maintenance levels should be used for energy analyses. A practical assay for TME has shown that TME estimates are less sensitive than AME to variation in food intake. The TME assay may be particularly useful in studies of natural foods that are difficult to obtain in quantities large enough to supply test birds with maintenance requirements. Energy budgets calculated from existence metabolism should be expressed as kJ of AME and converted to food requirements with estimates of metabolizability given in kJ AME/g.

Ames-2016 line lists for 13 isotopologues of CO2: Updates, consistency, and remaining issues

NASA Astrophysics Data System (ADS)

Huang (黄新川), Xinchuan; Schwenke, David W.; Freedman, Richard S.; Lee, Timothy J.

2017-12-01

A new 626-based Ames-2 PES refinement and Ames-2016 line lists for 13 CO2 isotopologues are reported. A consistent σRMS = ±0.02 cm-1 is established for hundreds of isotopologue band origins using the Ames-2 PES. Ames-2016 line lists are computed at 296 K, 1000 K and 4000 K using the Ames-2 PES and the same DMS-N2 dipole surface used previously, with J up to 150, E‧ up to 24,000 cm-1 or 18,000 cm-1 and appropriate intensity cutoffs. The lists are compared to the CDSD-296, CDSD-4000 databases, UCL line lists, and a few recent highly accurate CO2 intensity measurements. Both agreements and discrepancies are discussed. Compared to the old Ames CO2 lists, the Ames-2016 line lists have line position deviations reduced by 50% or more, which consequently leads to more reliable intensities. The line shape parameters in the Ames-2016 line lists are predicted using the newly assigned conventional vibrational polyad quantum numbers for rovibrational levels below 12,000 cm-1 so the quality of the line shape parameters is similar to that of CDSD or HITRAN. This study further proves that a semi-empirically refined PES (Ames-1 and Ames-2) coupled with a high quality ab initio DMS (DMS-N2 and UCL) may generate IR predictions with consistent accuracy and is thus helpful in the analysis of laboratory spectra and simulations of various isotopologues. The Ames-2016 lists based on DMS-N2 have reached the ∼1% intensity prediction accuracy level for the recent 626 30013-00001 and 20013-00001 bands, but further quantification and improvements require sub-percent or sub-half-percent accurate experimental intensities. The inter-isotopologue consistency of the intensity prediction accuracies should have reached better than 1-3% for regular bands not affected by resonances. Since the Effective Dipole Models (EDM) in CDSD and HITRAN have 1-20% or even larger uncertainties, we show that the Ames lists can provide better alternative IR data for many hard-to-determine isotopologue bands. Comparison at 4000 K suggests that the Ames-4000 K 12C16O2 line list is reliable and consistent within the current cutoffs of J ≤ 150 and E‧ ≤ 24,000 cm-1, but intensity contributions involving higher energy levels should not be omitted and future computations need to be converged up to at least 32,000 cm-1 or higher. The remaining issues are discussed regarding the source of energy level discrepancies, intensity underestimations by ∼50% for some weak bands, etc. and also future work.

Alcohol mixed with energy drink: Use may be a consequence of heavy drinking.

PubMed

Rossheim, Matthew E; Thombs, Dennis L; Weiler, Robert M; Barry, Adam E; Suzuki, Sumihiro; Walters, Scott T; Barnett, Tracey E; Paxton, Raheem J; Pealer, Lisa N; Cannell, Brad

2016-06-01

In recent years, studies have indicated that consumers of alcohol mixed with energy drink (AmED) are more likely to drink heavily and experience more negative consequences than consumers who avoid these beverages. Although researchers have identified a number of plausible hypotheses that explain how alcohol-energy drink co-ingestion could cause greater alcohol consumption, there has been no postulation about reverse causal relations. This paper identifies several plausible hypotheses for the observed associations between AmED consumption and greater alcohol consumption, and provides initial evidence for one such hypothesis suggesting that heavy drinking may be a determinant of AmED use. Data collected from 511bar patrons were used to examine the plausibility of one of the proposed hypotheses, i.e., AmED is an artifact of heavy drinking. Associations between the consumption of an assortment of alcoholic beverage types and total alcohol consumption were examined at the event-level, to assess whether AmED is uniquely related with greater alcohol consumption. Increased alcohol consumption was associated with greater odds of consuming most alcoholic beverage types; this association was not unique to AmED. Results support the overlooked hypothesis that AmED use is an artifact of heavy drinking. Thus, AmED consumption may be a consequence or marker of heavier drinking. Much of the existing research on alcoholic beverage types is limited in its ability to implicate any specific type of drink, including AmED, as a cause of increased alcohol consumption and related harm. More rigorous study designs are needed to examine causal relationships. Copyright © 2016 Elsevier Ltd. All rights reserved.

2017 Solar Eclipse, Ames Research Center

NASA Image and Video Library

2017-08-21

Taking a break from their duties at the Ames Vertical Gun Range to look up at the eclipse over Ames Research Center in Mountain View are from left to right are Alfredo "Freddie" Perez, Chuck Cornelison, Don Bowling, Adam Parish

ARC-2010-ACD10-0015-111

NASA Image and Video Library

2010-01-28

Ames 70th Anniversary Turn Back the Clock Day with antique Class Cars and Classic Car parade around the center. Lewis Braxton III, Ames Deputy Center Director and Jack Boyd, Ames Historian pose by Lew's Mustang before leading the parade.

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

PubMed Central

Csiszar, Anna; Labinskyy, Nazar; Perez, Viviana; Recchia, Fabio A.; Podlutsky, Andrej; Mukhopadhyay, Partha; Losonczy, Gyorgy; Pacher, Pal; Austad, Steven N.; Bartke, Andrzej; Ungvari, Zoltan

2008-01-01

Hypopituitary Ames dwarf mice have low circulating growth hormone (GH)/IGF-I levels, and they have extended longevity and exhibit many symptoms of delayed aging. To elucidate the vascular consequences of Ames dwarfism we compared endothelial O2•− and H2O2 production, mitochondrial reactive oxygen species (ROS) generation, expression of antioxidant enzymes, and nitric oxide (NO) production in aortas of Ames dwarf and wild-type control mice. In Ames dwarf aortas endothelial O2•− and H2O2 production and ROS generation by mitochondria were enhanced compared with those in vessels of wild-type mice. In Ames dwarf aortas there was a less abundant expression of Mn-SOD, Cu,Zn-SOD, glutathione peroxidase (GPx)-1, and endothelial nitric oxide synthase (eNOS). NO production and acetylcholine-induced relaxation were also decreased in aortas of Ames dwarf mice. In cultured wild-type mouse aortas and in human coronary arterial endothelial cells treatment with GH and IGF significantly reduced cellular O2•− and H2O2 production and ROS generation by mitochondria and upregulated expression of Mn-SOD, Cu,Zn-SOD, GPx-1, and eNOS. Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress. PMID:18757483

Effects of mixing alcohol with energy drink on objective and subjective intoxication: results from a Dutch on-premise study.

PubMed

Verster, J C; Benjaminsen, J M E; van Lanen, J H M; van Stavel, N M D; Olivier, B

2015-03-01

The purpose of this on-premise study was to determine if alcohol mixed with energy drink (AMED) consumption masks the subjective feelings of intoxication when compared to consuming alcohol only. The study was conducted on five nights in the city center of Utrecht. N = 997 people leaving bars were interviewed about their alcohol consumption with and without energy drinks, for that particular evening and for other occasions. People reporting drug and medication use were excluded (N = 84). Subjective intoxication was rated on a 10-point scale. Objective intoxication (breath alcohol concentration, BrAC) was determined with a breath alcohol test. Three groups were identified: (1) the AMED-tonight group (N = 185, 20.2 %), (2) the AMED-other-nights group (N = 246, 27.1 %), and (3) the no-AMED group (N = 482, 52.7 %). Objective intoxication (BrAC) did not significantly differ (p = 0.94) between the AMED-tonight group (0.074 % ± 0.05), AMED-other-nights group (0.073 % ± 0.05), and the no-AMED group (0.074 % ± 0.05). In line, subjective intoxication was not significantly different (p = 0.96) between the AMED-tonight group (4.5 ± 2.2), AMED-other-nights group (4.6 ± 2.3), and no-AMED group (4.6 ± 2.2). Within-subjects comparisons revealed no significant differences in total alcohol consumption between AMED occasions and alcohol only occasions. Regression analyses showed that "gender" (beta = 0.078, p = 0.016), "time of testing" (beta = 0.085, p = 0.009,) and "BrAC" (beta = 0.574, p = 0.0001) together explained 37.7 % of variance of subjective intoxication scores (Cohen's f (2) = 0.605). Whether or not subjects consumed energy drinks did not predict subjective intoxication scores. The data suggests that mixing alcohol with energy drink does not mask subjective intoxication.

AKARI and Spinning Dust: A look at microwave dust emission via the Infrared

NASA Astrophysics Data System (ADS)

Bell, Aaron Christopher; Onaka, Takashi; Wu, Ronin; Doi, Yasuo

2015-08-01

Rapidly spinning dust particles having a permanent electric dipole moment have been shown to be a likely carrier of the anomalous microwave emission (AME), a continuous excess of microwave flux in the 10 to 90 GHz range. Small grains, possibly polycyclic aromatic hydrocarbons (PAHs), are a leading suspect. Due to the overlap frequency overlap with the CMB, the AME is requiring cosmologists to consider the ISM with more care. ISM astronomers are also needing to consider the contribution of cosmological radiation to large-scale dust investigations. We present data from AKARI/Infrared Camera (IRC) due to the effective PAH band coverage of its 9 um survey to investigate PAH emission within 98 AME candidate regions identified by Planck Collaboration et al. (2014). We supplement AKARI data with the four Infrared Astronomical Satellite (IRAS) all-sky maps and complement with the Planck High Frequency Instrument (HFI) bands at 857 and 545GHz to constrain the full dust SED. We sample analyse the SEDs of all 98 regions. We utilize all 7 AKARI photometric bands, as well as the 4 IRAS bands and 2 HFI. We carry out a modified blackbody fitting, and estimate the optical depth of thermal dust at 250 um, and compare this to AME parameters. We also show plots of each band's average intensity for all 98 regions vs. AME parameters. We find a positive trend between the optical depth and AME. In the band-by-band comparison the AKARI 9 um intensity shows a weaker trend with AME. In general, the MIR correlates less strongly with AME than the FIR. The optical depth vs. AME trend improves slightly when looking only at significant AME regions. Scaling the IR intensities by the ISRF strength G0 does not improve the correlations. We cannot offer strong support of a spinning dust model. The results highlight the need for full dust SED modelling, and for a better understanding of the role that magnetic dipole emission from dust grains could play in producing the AME.

Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight

NASA Technical Reports Server (NTRS)

2002-01-01

Human Robotic Study at Houghton Crater - virtual reality study from NASA Ames (FFC) Future Fight Central simulator tower L-R: Dr Geoffrey Briggs; Jen Jasper (seated); Dr Jan Akins and Mr. Tony Gross, Ames

(New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Meets with

NASA Technical Reports Server (NTRS)

2002-01-01

(New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Meets with Roberto Cruz, National Hispanic University (left) at Amesto sign the educational MOU between NHU and Ames.

ARC-2006-ACD06-0230-021

NASA Image and Video Library

2006-12-15

Kick-off event for Google NASA collaboration (held in the Ames Exploration Center 943A) with Chris Kemp, Ames Business Development (L) Ames Center Director Pete Worden (L-M) Tiffany Montage, Project Manager Engineering, Google (R-M) and Dan Clancy, Director of engineering Google (R)

Center Overview and UAV Highlights at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Feng, Deborah; Yan, Jerry Chi Yiu

2017-01-01

The PowerPoint presentation gives an overview of NASA Ames Research Center and its core competencies, as well as some of the highlights of Unmanned Aerial Vehicle (UAV) and Unmanned Aircraft Systems (UAS) accomplishments and innovations by researchers at Ames.

Research and Technology

NASA Technical Reports Server (NTRS)

1987-01-01

Selected achievements at the Ames-Moffett and Ames-Dryden sites of the Ames Research Center are illustrated. The challenging work that was accomplished in the past year is presented for the following areas: engineering and technical services, aerospace systems, flight operations and research, aerophysics, and space research.

ARC-2006-ACD06-0179-003

NASA Image and Video Library

2006-10-12

Ames holds a Media Day at the Hypervelocity Free Flight facility where Ames is conducting high-speed tests of small models of the agency's new Orion CEV to learn about stability during flight. The hypervelocity test facility uses a gun to shoot Orion models between 0.5 and l.5 inches (1.25 - 3.75 centimeters in diameter. The facility can conduct experiments with speeds up to 19,000 miles per hour (30,400 kilometers per hour) with John Bluck (Ames PAO) and Chuck Cornelison Ames Engineer

Connective Auxin Transport in the Shoot Facilitates Communication between Shoot Apices

PubMed Central

Bennett, Tom; Hines, Geneviève; van Rongen, Martin; Sawchuk, Megan G.; Scarpella, Enrico; Ljung, Karin

2016-01-01

The bulk polar movement of the plant signaling molecule auxin through the stem is a long-recognized but poorly understood phenomenon. Here we show that the highly polar, high conductance polar auxin transport stream (PATS) is only part of a multimodal auxin transport network in the stem. The dynamics of auxin movement through stems are inconsistent with a single polar transport regime and instead suggest widespread low conductance, less polar auxin transport in the stem, which we term connective auxin transport (CAT). The bidirectional movement of auxin between the PATS and the surrounding tissues, mediated by CAT, can explain the complex auxin transport kinetics we observe. We show that the auxin efflux carriers PIN3, PIN4, and PIN7 are major contributors to this auxin transport connectivity and that their activity is important for communication between shoot apices in the regulation of shoot branching. We propose that the PATS provides a long-range, consolidated stream of information throughout the plant, while CAT acts locally, allowing tissues to modulate and be modulated by information in the PATS. PMID:27119525

The influence of energy standardisation on the alternate Mediterranean diet score and its association with mortality in the Multiethnic Cohort.

PubMed

Shvetsov, Yurii B; Harmon, Brook E; Ettienne, Reynolette; Wilkens, Lynne R; Le Marchand, Loic; Kolonel, Laurence N; Boushey, Carol J

2016-11-01

The alternate Mediterranean diet (aMED) score is an adaptation of the original Mediterranean diet score. Raw (aMED) and energy-standardised (aMED-e) versions have been used. How the diet scores and their association with health outcomes differ between the two versions is unclear. We examined differences in participants' total and component scores and compared the association of aMED and aMED-e with all-cause, CVD and cancer mortality. As part of the Multiethnic Cohort, 193 527 men and women aged 45-75 years from Hawaii and Los Angeles completed a baseline FFQ and were followed up for 13-18 years. The association of aMED and aMED-e with mortality was examined using Cox's regression, with adjustment for total energy intake. The correlation between aMED and aMED-e total scores was lower among people with higher BMI. Participants who were older, leaner, more educated and consumed less energy scored higher on aMED-e components compared with aMED, except for the red and processed meat and alcohol components. Men reporting more physical activity scored lower on most aMED-e components compared with aMED, whereas the opposite was observed for the meat component. Higher scores of both aMED and aMED-e were associated with lower risk of all-cause, CVD and cancer mortality. Although individuals may score differently with aMED and aMED-e, both scores show similar reductions in mortality risk for persons scoring high on the index scale. Either version can be used in studies of diet and mortality. Comparisons can be performed across studies using different versions of the score.

Alcohol mixed with energy drinks: Associations with risky drinking and functioning in high school.

PubMed

Tucker, Joan S; Troxel, Wendy M; Ewing, Brett A; D'Amico, Elizabeth J

2016-10-01

Mixing alcohol with energy drinks is associated with heavier drinking and related problems among college students. However, little is known about how high school drinkers who mix alcohol with energy drinks (AmED) compare to those who do not (AwoED). This study compares high school AmED and AwoED users on their alcohol use during middle and high school, as well as key domains of functioning in high school. Two surveys were conducted three years apart in adolescents initially recruited from 16 middle schools in Southern California. The analytic sample consists of 696 past month drinkers. Multivariable models compared AmED and AwoED users on alcohol use, mental health, social functioning, academic orientation, delinquency and other substance use at age 17, and on their alcohol use and related cognitions at age 14. AmED was reported by 13% of past month drinkers. AmED and AwoED users did not differ on alcohol use or cognitions in middle school, but AmED users drank more often, more heavily, and reported more negative consequences in high school. AmED users were also more likely to report poor grades, delinquent behavior, substance use-related unsafe driving, public intoxication, and drug use than AwoED users in high school. Group differences were not found on mental health, social functioning, or academic aspirations. AmED use is common among high school drinkers. The higher risk behavioral profile of these young AmED users, which includes drug use and substance use-related unsafe driving, is a significant cause for concern and warrants further attention. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus.

PubMed

Carasatorre, Mariana; Ochoa-Alvarez, Adrian; Velázquez-Campos, Giovanna; Lozano-Flores, Carlos; Ramírez-Amaya, Víctor; Díaz-Cintra, Sofía Y

2015-01-01

Spatial water maze (WM) overtraining induces hippocampal mossy fiber (MF) expansion, and it has been suggested that spatial pattern separation depends on the MF pathway. We hypothesized that WM experience inducing MF expansion in rats would improve spatial pattern separation in the hippocampal network. We first tested this by using the the delayed non-matching to place task (DNMP), in animals that had been previously trained on the water maze (WM) and found that these animals, as well as animals treated as swim controls (SC), performed better than home cage control animals the DNMP task. The "catFISH" imaging method provided neurophysiological evidence that hippocampal pattern separation improved in animals treated as SC, and this improvement was even clearer in animals that experienced the WM training. Moreover, these behavioral treatments also enhance network reliability and improve partial pattern separation in CA1 and pattern completion in CA3. By measuring the area occupied by synaptophysin staining in both the stratum oriens and the stratun lucidum of the distal CA3, we found evidence of structural synaptic plasticity that likely includes MF expansion. Finally, the measures of hippocampal network coding obtained with catFISH correlate significantly with the increased density of synaptophysin staining, strongly suggesting that structural synaptic plasticity in the hippocampus induced by the WM and SC experience is related to the improvement of spatial information processing in the hippocampus.

Neural Network Modeling of UH-60A Pilot Vibration

NASA Technical Reports Server (NTRS)

Kottapalli, Sesi

2003-01-01

Full-scale flight-test pilot floor vibration is modeled using neural networks and full-scale wind tunnel test data for low speed level flight conditions. Neural network connections between the wind tunnel test data and the tlxee flight test pilot vibration components (vertical, lateral, and longitudinal) are studied. Two full-scale UH-60A Black Hawk databases are used. The first database is the NASMArmy UH-60A Airloads Program flight test database. The second database is the UH-60A rotor-only wind tunnel database that was acquired in the NASA Ames SO- by 120- Foot Wind Tunnel with the Large Rotor Test Apparatus (LRTA). Using neural networks, the flight-test pilot vibration is modeled using the wind tunnel rotating system hub accelerations, and separately, using the hub loads. The results show that the wind tunnel rotating system hub accelerations and the operating parameters can represent the flight test pilot vibration. The six components of the wind tunnel N/rev balance-system hub loads and the operating parameters can also represent the flight test pilot vibration. The present neural network connections can significandy increase the value of wind tunnel testing.

Mass balances of dissolved gases at river network scales across biomes.

NASA Astrophysics Data System (ADS)

Wollheim, W. M.; Stewart, R. J.; Sheehan, K.

2016-12-01

Estimating aquatic metabolism and gas fluxes at broad spatial scales is needed to evaluate the role of aquatic ecosystems in continental carbon cycles. We applied a river network model, FrAMES, to quantify the mass balances of dissolved oxygen at river network scales across five river networks in different biomes. The model accounts for hydrology; spatially varying re-aeration rates due to flow, slope, and water temperature; gas inputs via terrestrial runoff; variation in light due to canopy cover and water depth; benthic gross primary production; and benthic respiration. The model was parameterized using existing groundwater information and empirical relationships of GPP, R, and re-aeration, and was tested using dissolved oxygen patterns measured throughout river networks. We found that during summers, internal aquatic production dominates the river network mass balance of Kings Cr., Konza Prairie, KS (16.3 km2), whereas terrestrial inputs and aeration dominate the network mass balance at Coweeta Cr., Coweeta Forest, NC (15.7 km2). At network scales, both river networks are net heterotrophic, with Coweeta more so than Kings Cr. (P:R 0.6 vs. 0.7, respectively). The river network of Kings Creek showed higher network-scale GPP and R compared to Coweeta, despite having a lower drainage density because streams are on average wider so cumulative benthic surface areas are similar. Our findings suggest that the role of aquatic systems in watershed carbon balances will depend on interactions of drainage density, channel hydraulics, terrestrial vegetation, and biological activity.

Semantic Web Infrastructure Supporting NextFrAMES Modeling Platform

NASA Astrophysics Data System (ADS)

Lakhankar, T.; Fekete, B. M.; Vörösmarty, C. J.

2008-12-01

Emerging modeling frameworks offer new ways to modelers to develop model applications by offering a wide range of software components to handle common modeling tasks such as managing space and time, distributing computational tasks in parallel processing environment, performing input/output and providing diagnostic facilities. NextFrAMES, the next generation updates to the Framework for Aquatic Modeling of the Earth System originally developed at University of New Hampshire and currently hosted at The City College of New York takes a step further by hiding most of these services from modeler behind a platform agnostic modeling platform that allows scientists to focus on the implementation of scientific concepts in the form of a new modeling markup language and through a minimalist application programming interface that provide means to implement model processes. At the core of the NextFrAMES modeling platform there is a run-time engine that interprets the modeling markup language loads the module plugins establishes the model I/O and executes the model defined by the modeling XML and the accompanying plugins. The current implementation of the run-time engine is designed for single processor or symmetric multi processing (SMP) systems but future implementation of the run-time engine optimized for different hardware architectures are anticipated. The modeling XML and the accompanying plugins define the model structure and the computational processes in a highly abstract manner, which is not only suitable for the run-time engine, but has the potential to integrate into semantic web infrastructure, where intelligent parsers can extract information about the model configurations such as input/output requirements applicable space and time scales and underlying modeling processes. The NextFrAMES run-time engine itself is also designed to tap into web enabled data services directly, therefore it can be incorporated into complex workflow to implement End-to-End application from observation to the delivery of highly aggregated information. Our presentation will discuss the web services ranging from OpenDAP and WaterOneFlow data services to metadata provided through catalog services that could serve NextFrAMES modeling applications. We will also discuss the support infrastructure needed to streamline the integration of NextFrAMES into an End-to-End application to deliver highly processed information to end users. The End-to-End application will be demonstrated through examples from the State-of-the Global Water System effort that builds on data services provided through WMO's Global Terrestrial Network for Hydrology to deliver water resources related information to policy makers for better water management. Key components of this E2E system are promoted as Community of Practice examples for the Global Observing System of Systems therefore the State-of-the Global Water System can be viewed as test case for the interoperability of the incorporated web service components.

AMES Stereo Pipeline Derived DEM Accuracy Experiment Using LROC-NAC Stereopairs and Weighted Spatial Dependence Simulation for Lunar Site Selection

NASA Astrophysics Data System (ADS)

Laura, J. R.; Miller, D.; Paul, M. V.

2012-03-01

An accuracy assessment of AMES Stereo Pipeline derived DEMs for lunar site selection using weighted spatial dependence simulation and a call for outside AMES derived DEMs to facilitate a statistical precision analysis.

Characteristics of university students who mix alcohol and energy drinks.

PubMed

Bonar, Erin E; Green, Michaela R; Ashrafioun, Lisham

2017-01-01

Research has identified correlates (eg, drug use, risky sex, smoking) of using alcohol mixed with energy drinks (AMEDs). Few studies have investigated common mental health-related concerns (eg, depression, sleep). Alcohol-using college students (n = 380 never used AMEDs, n = 180 used AMEDs) were recruited in the study during the fall 2011 semester. The study examined demographics, substance use, depressive symptoms, and sleep problems in association with AMED use. Multivariable logistic regression indicated that alcohol use severity (AOR = 1.24; 95% CI = 1.14+1.34), drug use severity (AOR = 1.20; 95% CI = 1.04-1.39), depressive symptoms (AOR = 1.06; 95% CI = 1.01-1.12), and smoking (AOR = 2.12; 95% CI = 1.22-3.68) were independently associated with AMED use; sleep problems were non-significant. Administrators may consider policies regarding energy drink availability on campus, and campus health personnel may increase screening and education surrounding AMED use to reduce risks among students.

Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008.

PubMed

2012-12-14

Quality surveillance is critical to the control and elimination of vaccine-preventable diseases (VPDs). A key strategy for enhancing VPD surveillance, outlined in the World Health Organization (WHO) Global Framework for Immunization Monitoring and Surveillance (GFIMS), is to expand and link existing VPD surveillance systems (particularly those developed for polio eradication and measles elimination) to include other priority VPDs. Since the launch of the Global Polio Eradication Initiative in 1988, the incidence of polio has decrease by 99% worldwide. A cornerstone of this success is a sensitive surveillance system based on the rapid and timely reporting of all acute flaccid paralysis (AFP) cases in children aged <15 years, with confirmatory diagnostic testing performed by laboratories that are part of a global network. As countries achieve polio-free status, many have expanded syndromic surveillance to include persons with rash and fever, and have built measles diagnostic capacity in existing polio reference laboratories. Acute meningitis/encephalitis syndrome (AMES) and acute encephalitis syndrome (AES) are candidates for expanded surveillance because they are most often caused by VPDs of public health importance for which confirmatory laboratory tests exist. Vaccine-preventable cases of encephalitis include approximately 68,000 Japanese encephalitis (JE) cases, resulting in 13,000-20,000 deaths each year in Asia. Moreover, although bacterial meningitis incidence in Asia is not as well-documented, pneumococcal and meningococcal meningitis outbreaks have been reported in Bangladesh and China, and the incidence of Haemophilus influenzae type b (Hib) meningitis in children aged <5 years in India has been estimated to be 7.1 per 100,000 population, similar to that in European countries before the introduction of vaccine. This report describes a prototype for expanding existing polio and measles surveillance networks in Bangladesh, China, and India to include surveillance for viral and bacterial vaccine-preventable causes of AMES and AES and presents data from 2006-2008.

Peroxisomal membrane ascorbate peroxidase is sorted to a membranous network that resembles a subdomain of the endoplasmic reticulum.

PubMed Central

Mullen, R T; Lisenbee, C S; Miernyk, J A; Trelease, R N

1999-01-01

The peroxisomal isoform of ascorbate peroxidase (APX) is a novel membrane isoform that functions in the regeneration of NAD(+) and protection against toxic reactive oxygen species. The intracellular localization and sorting of peroxisomal APX were examined both in vivo and in vitro. Epitope-tagged peroxisomal APX, which was expressed transiently in tobacco BY-2 cells, localized to a reticular/circular network that resembled endoplasmic reticulum (ER; 3,3'-dihexyloxacarbocyanine iodide-stained membranes) and to peroxisomes. The reticular network did not colocalize with other organelle marker proteins, including three ER reticuloplasmins. However, in vitro, peroxisomal APX inserted post-translationally into the ER but not into other purified organelle membranes (including peroxisomal membranes). Insertion into the ER depended on the presence of molecular chaperones and ATP. These results suggest that regions of the ER serve as a possible intermediate in the sorting pathway of peroxisomal APX. Insight into this hypothesis was obtained from in vivo experiments with brefeldin A (BFA), a toxin that blocks vesicle-mediated protein export from ER. A transiently expressed chloramphenicol acetyltransferase-peroxisomal APX (CAT-pAPX) fusion protein accumulated only in the reticular/circular network in BFA-treated cells; after subsequent removal of BFA from these cells, the CAT-pAPX was distributed to preexisting peroxisomes. Thus, plant peroxisomal APX, a representative enzymatic peroxisomal membrane protein, is sorted to peroxisomes through an indirect pathway involving a preperoxisomal compartment with characteristics of a distinct subdomain of the ER, possibly a peroxisomal ER subdomain. PMID:10559442

Ames Lab 101: Lanthanum Decanting

ScienceCinema

Riedemann, Trevor

2018-04-27

Ames Laboratory scientist Trevor Riedemann explains the process that allows Ames Laboratory to produce some of the purest lanthanum in the world. This and other high-purity rare-earth elements are used to create alloys used in various research projects and play a crucial role in the Planck satellite mission.

ARC-2009-ACD09-0141-016

NASA Image and Video Library

2009-07-16

Dr William 'Bill' Borucki, NASA Ames Scientist on the Kepler Mission and John W. 'Jack' Boyd, NASA Ames Historian at the Ames Arc Jet Complex, Aerodynamic Heating Facility talking with a Mercury News photographer about the Kepler Mission and the 40th Anniversary of the Apollo 11 Mission.

ARC-2009-ACD09-0141-015

NASA Image and Video Library

2009-07-16

Dr William 'Bill' Borucki, NASA Ames Scientist on the Kepler Mission and John W. 'Jack' Boyd, NASA Ames Historian at the Ames Arc Jet Complex, Aerodynamic Heating Facility talking with a Mercury News photographer about the Kepler Mission and the 40th Anniversary of the Apollo 11 Mission.

ARC-2007-ACD07-0065-028

NASA Image and Video Library

2007-04-12

Ames Video group during interviewing Dave Lathem, Harvard Smithsonian Center for Astrophysics, Cambridge, MR at the SETI Institute during a NASA Ames Kepler Mission conference. Dave Maurantonio, Ed Schilling, Bill Moede, and Eric Land, Ames/Planners Video crew (Kepler a search for habitable planets was selected for Discovery Program)

(New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Here he welcomes

NASA Technical Reports Server (NTRS)

2002-01-01

(New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Here he welcomes JASON kids to NASA while handing out patches and pins. Tom Clausen and Donald James, Ames Education Office in background.

Ames Lab 101: Rare Earths

ScienceCinema

Gschneidner, Karl

2017-12-11

"Mr. Rare Earth," Ames Laboratory scientist Karl Gschneidner Jr., explains the importance of rare-earth materials in many of the technologies we use today -- ranging from computers to hybrid cars to wind turbines. Gschneidner is a world renowned rare-earths expert at the U.S. Department of Energy's Ames Laboratory.

Quantifying Climate Change Hydrologic Risk at NASA Ames Research Center

NASA Astrophysics Data System (ADS)

Mills, W. B.; Bromirski, P. D.; Coats, R. N.; Costa-Cabral, M.; Fong, J.; Loewenstein, M.; Milesi, C.; Miller, N.; Murphy, N.; Roy, S.

2013-12-01

In response to 2009 Executive Order 13514 mandating U.S. federal agencies to evaluate infrastructure vulnerabilities due to climate variability and change we provide an analysis of future climate flood risk at NASA Ames Research Center (Ames) along South S.F. Bay. This includes likelihood analysis of large-scale water vapor transport, statistical analysis of intense precipitation, high winds, sea level rise, storm surge, estuary dynamics, saturated overland flooding, and likely impacts to wetlands and habitat loss near Ames. We use the IPCC CMIP5 data from three Atmosphere-Ocean General Circulation Models with Radiative Concentration Pathways of 8.5 Wm-2 and 4.5 Wm-2 and provide an analysis of climate variability and change associated with flooding and impacts at Ames. Intense storms impacting Ames are due to two large-scale processes, sub-tropical atmospheric rivers (AR) and north Pacific Aleutian low-pressure (AL) storm systems, both of which are analyzed here in terms of the Integrated Water Vapor (IWV) exceeding a critical threshold within a search domain and the wind vector transporting the IWV from southerly to westerly to northwesterly for ARs and northwesterly to northerly for ALs and within the Ames impact area during 1970-1999, 2040-2069, and 2070-2099. We also include a statistical model of extreme precipitation at Ames based on large-scale climatic predictors, and characterize changes using CMIP5 projections. Requirements for levee height to protect Ames are projected to increase and continually accelerate throughout this century as sea level rises. We use empirical statistical and analytical methods to determine the likelihood, in each year from present through 2099, of water level surpassing different threshold values in SF Bay near NASA Ames. We study the sensitivity of the water level corresponding to a 1-in-10 and 1-in-100 likelihood of exceedance to changes in the statistical distribution of storm surge height and ENSO height, in addition to increasing mean sea level. We examine the implications in the face of the CMIP5 projections. Storm intensification may result in increased flooding hazards at Ames. We analyze how the changes in precipitation intensity will impact the storm drainage system at Ames through continuous stormwater modeling of runoff with the EPA model SWMM 5 and projected downscaled daily precipitation data. Although extreme events will not adversely affect wetland habitats, adaptation projects--especially levee construction and improvement--will require filling of wetlands. Federal law mandates mitigation for fill placed in wetlands. We are currently calculating the potential mitigation burden by habitat type.

SSBRP User Operations Facility (UOF) Overview and Development Strategy

NASA Technical Reports Server (NTRS)

Picinich, Lou; Stone, Thom; Sun, Charles; Windrem, May; Givens, John J. (Technical Monitor)

1995-01-01

This paper will present the Space Station Biological Research Project (SSBRP) User Operations Facility (UOF) architecture and development strategy. A major element of the UOF at NASA Ames Research Center, the Communication and Data System (CDS) will be the primary focus of the discussions. CDS operational, telescience, security, and development objectives will be discussed along with CDS implementation strategy. The implementation strategy discussions will include: Object Oriented Analysis & Design, System & Software Prototyping, and Technology Utilization. A CDS design overview that includes: CDS Context Diagram, CDS Architecture, Object Models, Use Cases, and User Interfaces will also be presented. CDS development brings together "cutting edge" technologies and techniques such as: object oriented development, network security, multimedia networking, web-based data distribution, JAVA, and graphical user interfaces. Use of these "cutting edge" technologies and techniques translates directly to lower development and operations costs.

Recent Geological and Hydrological Activity in Amazonis and Elysium Basins and Their Link, Marte Valles (AME): Prime Target for Future Reconnaissance

NASA Astrophysics Data System (ADS)

Dohm, J. M.; Robbins, S. J.; Hynek, B. M.

2012-03-01

Amazonis and Elysium basins and their link, Marte Vallis (AME), uniquely point to a geologically and hydrologically active Mars. We will present evidence for why AME reconnaissance can help address whether Mars is geologically, hydrologically, and biologically active.

NASA Ames and Traveling Space Museum Host Space Day at Bay Area Schools (Version 2 - Final)

NASA Image and Video Library

2010-08-10

NASA Ames and the Traveling Space Museum visited under-represented students in the Bay Area in an effort to excite them to the possibilities in science, technology, engineering and mathematics. Includes soundbites from Lewis Braxton III (NASA Ames) and actress Nichelle Nichols (TSM).

2017 Solar Eclipse, Ames Research Center

NASA Image and Video Library

2017-08-21

Taking a break from his duties at the Ames Vertical Gun Range to look up at the eclipse over Ames Research Center in Mountain View Adam Parrish not only views but wears, on his forehead, the image of the 2017 Solar eclipse at 09:20:56 on August 21, 2017.

NASA Administrator Visits Ames Research Center (Reporter Pkg - May 2013)

NASA Image and Video Library

2013-05-24

NASA Administrator Charles Bolden and Congressman Mike Honda (D-San Jose, CA) were special guests at Ames Research Center recently. During their visit, they visited the SpaceShop, where they were shown demonstrations of Ames' contributions to the PhoneSat nano-satellite mission and 3D printing activity

Department of Energy National Laboratories A - L

Science.gov Websites

contributors to science and research. This high-level compilation of their history and achievements provides insights into their previous successes and continuing efforts. dropdown listing Ames Laboratory Our History The Ames Project (1942-1946) Ames Laboratory Hot Canyon A History of Innovation Points of Pride Recent

A note on the revised galactic neutron spectrum of the Ames collaborative study

NASA Technical Reports Server (NTRS)

Schaefer, H. J.

1980-01-01

Energy distributions of the neutron dose equivalents in the 0.1 to 300 Mev interval for the Ames and Hess spectra are compared. The Ames spectrum shows no evaporation peak, moves the bulk of the flux away from the region of elastic collision and spreads it more evenly over higher energies. The neutron spectrum in space does not seem to hear out the Ames model. Emulsion findings on all manned missions of the past consistently indicate that evaporation events are a prolific source of neutrons in space.

ARC-2006-ACD06-0179-007

NASA Image and Video Library

2006-10-12

Ames holds a Media Day at the Hypervelocity Free Flight facility where Ames is conducting high-speed tests of small models of the agency's new Orion CEV to learn about stability during flight. The hypervelocity test facility uses a gun to shoot Orion models between 0.5 and l.5 inches (1.25 - 3.75 centimeters in diameter. The facility can conduct experiments with speeds up to 19,000 miles per hour (30,400 kilometers per hour) - ABC Camerman in forground, Wayne Freedman ABC reporter, Jeff Brown (Ames-ASA), John Bluck (AMES PAO)

The microRNA ame-miR-279a regulates sucrose responsiveness of forager honey bees (Apis mellifera).

PubMed

Liu, Fang; Shi, Tengfei; Yin, Wei; Su, Xin; Qi, Lei; Huang, Zachary Y; Zhang, Shaowu; Yu, Linsheng

2017-11-01

Increasing evidence demonstrates that microRNAs (miRNA) play an important role in the regulation of animal behaviours. Honey bees (Apis mellifera) are eusocial insects, with honey bee workers displaying age-dependent behavioural maturation. Many different miRNAs have been implicated in the change of behaviours in honey bees and ame-miR-279a was previously shown to be more highly expressed in nurse bee heads than in those of foragers. However, it was not clear whether this difference in expression was associated with age or task performance. Here we show that ame-miR-279a shows significantly higher expression in the brains of nurse bees relative to forager bees regardless of their ages, and that ame-miR-279a is primarily localized in the Kenyon cells of the mushroom body in both foragers and nurses. Overexpression of ame-miR-279a attenuates the sucrose responsiveness of foragers, while its absence enhances their sucrose responsiveness. Lastly, we determined that ame-miR-279a directly target the mRNA of Mblk-1. These findings suggest that ame-miR-279a plays important roles in regulating honey bee division of labour. Copyright © 2017 Elsevier Ltd. All rights reserved.

Developing Global Building Exposure for Disaster Forecasting, Mitigation, and Response

NASA Astrophysics Data System (ADS)

Huyck, C. K.

2016-12-01

Nongovernmental organizations and governments are recognizing the importance of insurance penetration in developing countries to mitigate the tremendous setbacks that follow natural disasters., but to effectively manage risk stakeholders must accurately quantify the built environment. Although there are countless datasets addressing elements of buildings, there are surprisingly few that are directly applicable to assessing vulnerability to natural disasters without skewing the spatial distribution of risk towards known assets. Working with NASA center partners Center for International Earth Science Information Network (CIESIN) at Columbia University in New York (http://www.ciesin.org), ImageCat have developed a novel method of developing Global Exposure Data (GED) from EO sources. The method has been applied to develop exposure datasets for GFDRR, CAT modelers, and aid in post-earthquake allocation of resources for UNICEF.

Tools for 3D scientific visualization in computational aerodynamics

NASA Technical Reports Server (NTRS)

Bancroft, Gordon; Plessel, Todd; Merritt, Fergus; Watson, Val

1989-01-01

The purpose is to describe the tools and techniques in use at the NASA Ames Research Center for performing visualization of computational aerodynamics, for example visualization of flow fields from computer simulations of fluid dynamics about vehicles such as the Space Shuttle. The hardware used for visualization is a high-performance graphics workstation connected to a super computer with a high speed channel. At present, the workstation is a Silicon Graphics IRIS 3130, the supercomputer is a CRAY2, and the high speed channel is a hyperchannel. The three techniques used for visualization are post-processing, tracking, and steering. Post-processing analysis is done after the simulation. Tracking analysis is done during a simulation but is not interactive, whereas steering analysis involves modifying the simulation interactively during the simulation. Using post-processing methods, a flow simulation is executed on a supercomputer and, after the simulation is complete, the results of the simulation are processed for viewing. The software in use and under development at NASA Ames Research Center for performing these types of tasks in computational aerodynamics is described. Workstation performance issues, benchmarking, and high-performance networks for this purpose are also discussed as well as descriptions of other hardware for digital video and film recording.

Comprehensive Software Eases Air Traffic Management

NASA Technical Reports Server (NTRS)

2007-01-01

To help air traffic control centers improve the safety and the efficiency of the National Airspace System, Ames Research Center developed the Future Air Traffic Management Concepts Evaluation Tool (FACET) software, which won NASA's 2006 "Software of the Year" competition. In 2005, Ames licensed FACET to Flight Explorer Inc., for integration into its Flight Explorer (version 6.0) software. The primary FACET features incorporated in the Flight Explorer software system alert airspace users to forecasted demand and capacity imbalances. Advance access to this information helps dispatchers anticipate congested sectors (airspace) and delays at airports, and decide if they need to reroute flights. FACET is now a fully integrated feature in the Flight Explorer Professional Edition (version 7.0). Flight Explorer Professional offers end-users other benefits, including ease of operation; automatic alerts to inform users of important events such as weather conditions and potential airport delays; and international, real-time flight coverage over Canada, the United Kingdom, New Zealand, and sections of the Atlantic and Pacific Oceans. Flight Explorer Inc. recently broadened coverage by partnering with Honeywell International Inc.'s Global Data Center, Blue Sky Network, Sky Connect LLC, SITA, ARINC Incorporated, Latitude Technologies Corporation, and Wingspeed Corporation, to track their aircraft anywhere in the world.

Minimization of Basis Risk in Parametric Earthquake Cat Bonds

NASA Astrophysics Data System (ADS)

Franco, G.

2009-12-01

A catastrophe -cat- bond is an instrument used by insurance and reinsurance companies, by governments or by groups of nations to cede catastrophic risk to the financial markets, which are capable of supplying cover for highly destructive events, surpassing the typical capacity of traditional reinsurance contracts. Parametric cat bonds, a specific type of cat bonds, use trigger mechanisms or indices that depend on physical event parameters published by respected third parties in order to determine whether a part or the entire bond principal is to be paid for a certain event. First generation cat bonds, or cat-in-a-box bonds, display a trigger mechanism that consists of a set of geographic zones in which certain conditions need to be met by an earthquake’s magnitude and depth in order to trigger payment of the bond principal. Second generation cat bonds use an index formulation that typically consists of a sum of products of a set of weights by a polynomial function of the ground motion variables reported by a geographically distributed seismic network. These instruments are especially appealing to developing countries with incipient insurance industries wishing to cede catastrophic losses to the financial markets because the payment trigger mechanism is transparent and does not involve the parties ceding or accepting the risk, significantly reducing moral hazard. In order to be successful in the market, however, parametric cat bonds have typically been required to specify relatively simple trigger conditions. The consequence of such simplifications is the increase of basis risk. This risk represents the possibility that the trigger mechanism fails to accurately capture the actual losses of a catastrophic event, namely that it does not trigger for a highly destructive event or vice versa, that a payment of the bond principal is caused by an event that produced insignificant losses. The first case disfavors the sponsor who was seeking cover for its losses while the second disfavors the investor who loses part of the investment without a reasonable cause. A streamlined and fairly automated methodology has been developed to design parametric triggers that minimize the basis risk while still maintaining their level of relative simplicity. Basis risk is minimized in both, first and second generation, parametric cat bonds through an optimization procedure that aims to find the most appropriate magnitude thresholds, geographic zones, and weight index values. Sensitivity analyses to different design assumptions show that first generation cat bonds are typically affected by a large negative basis risk, namely the risk that the bond will not trigger for events within the risk level transferred, unless a sufficiently small geographic resolution is selected to define the trigger zones. Second generation cat bonds in contrast display a bias towards negative or positive basis risk depending on the degree of the polynomial used as well as on other design parameters. Two examples are presented, the construction of a first generation parametric trigger mechanism for Costa Rica and the design of a second generation parametric index for Japan.

Atomistic Texture of Amorphous Manganese Oxides for Electrochemical Water Splitting Revealed by Ab Initio Calculations Combined with X-ray Spectroscopy.

PubMed

Mattioli, Giuseppe; Zaharieva, Ivelina; Dau, Holger; Guidoni, Leonardo

2015-08-19

Amorphous transition-metal (hydr)oxides are considered as the most promising catalysts that promote the oxidation of water to molecular oxygen, protons, and "energized" electrons, and, in turn, as fundamental parts of "artificial leaves" that can be exploited for large scale generation of chemical fuels (e.g., hydrogen) directly from sunlight. We present here a joint theoretical-experimental investigation of electrodeposited amorphous manganese oxides with different catalytic activities toward water oxidation (MnCats). Combining the information content of X-ray absorption fine structure (XAFS) measurements with the predictive power of ab initio calculations based on density functional theory, we have been able to identify the essential structural and electronic properties of MnCats. We have elucidated (i) the localization and structural connection of Mn(II), Mn(III), and Mn(IV) ions in such amorphous oxides and (ii) the distribution of protons at the MnCat/water interface. Our calculations result in realistic 3D models of the MnCat atomistic texture, formed by the interconnection of small planar Mn-oxo sheets cross-linked through different kinds of defective Mn atoms, isolated or arranged in closed cubane-like units. Essential for the catalytic activity is the presence of undercoordinated Mn(III)O5 units located at the boundary of the amorphous network, where they are ready to act as hole traps that trigger the oxidation of neighboring water molecules when the catalyst is exposed to an external positive potential. The present validation of a sound 3D model of MnCat improves the accuracy of XAFS fits and opens the way for the development of mechanistic schemes of its functioning beyond a speculative level.

Embedded Data Processor and Portable Computer Technology testbeds

NASA Technical Reports Server (NTRS)

Alena, Richard; Liu, Yuan-Kwei; Goforth, Andre; Fernquist, Alan R.

1993-01-01

Attention is given to current activities in the Embedded Data Processor and Portable Computer Technology testbed configurations that are part of the Advanced Data Systems Architectures Testbed at the Information Sciences Division at NASA Ames Research Center. The Embedded Data Processor Testbed evaluates advanced microprocessors for potential use in mission and payload applications within the Space Station Freedom Program. The Portable Computer Technology (PCT) Testbed integrates and demonstrates advanced portable computing devices and data system architectures. The PCT Testbed uses both commercial and custom-developed devices to demonstrate the feasibility of functional expansion and networking for portable computers in flight missions.

The CSM testbed software system: A development environment for structural analysis methods on the NAS CRAY-2

NASA Technical Reports Server (NTRS)

Gillian, Ronnie E.; Lotts, Christine G.

1988-01-01

The Computational Structural Mechanics (CSM) Activity at Langley Research Center is developing methods for structural analysis on modern computers. To facilitate that research effort, an applications development environment has been constructed to insulate the researcher from the many computer operating systems of a widely distributed computer network. The CSM Testbed development system was ported to the Numerical Aerodynamic Simulator (NAS) Cray-2, at the Ames Research Center, to provide a high end computational capability. This paper describes the implementation experiences, the resulting capability, and the future directions for the Testbed on supercomputers.

Airport Simulations Using Distributed Computational Resources

NASA Technical Reports Server (NTRS)

McDermott, William J.; Maluf, David A.; Gawdiak, Yuri; Tran, Peter; Clancy, Daniel (Technical Monitor)

2002-01-01

The Virtual National Airspace Simulation (VNAS) will improve the safety of Air Transportation. In 2001, using simulation and information management software running over a distributed network of super-computers, researchers at NASA Ames, Glenn, and Langley Research Centers developed a working prototype of a virtual airspace. This VNAS prototype modeled daily operations of the Atlanta airport by integrating measured operational data and simulation data on up to 2,000 flights a day. The concepts and architecture developed by NASA for this prototype are integral to the National Airspace Simulation to support the development of strategies improving aviation safety, identifying precursors to component failure.

Quantitative analysis of precipitation over Fukushima to understand the wet deposition process in March 2011

NASA Astrophysics Data System (ADS)

Yatagai, A.; Onda, Y.; Watanabe, A.

2012-04-01

The Great East Japan Earthquake caused a severe accident at the Fukushima-Daiichi nuclear power plant (NPP), leading to the emission of large amounts of radioactive pollutants into the environment. The transport and diffusion of these radioactive pollutants in the atmosphere caused a disaster for residents in and around Fukushima. Studies have sought to understand the transport, diffusion, and deposition process, and to understand the movement of radioactive pollutants through the soil, vegetation, rivers, and groundwater. However, a detailed simulation and understanding of the distribution of radioactive compounds depend on a simulation of precipitation and on the information on the timing of the emission of these radioactive pollutants from the NPP. Past nuclear expansion studies have demonstrated the importance of wet deposition in distributing pollutants. Hence, this study examined the quantitative precipitation pattern in March 2011 using rain-gauge observations and X-band radar data from Fukushima University. We used the AMeDAS rain-gauge network data of 1) the Japan Meteorological Agency (1273 stations in Japan) and 2) the Water Information System (47 stations in Fukushima prefecture) and 3) the rain-gauge data of the Environmental Information Network of NTT Docomo (30 stations in Fukushima) to construct 0.05-degree mesh data using the same method used to create the APHRODITE daily grid precipitation data (Yatagai et al., 2009). Since some AMeDAS data for the coastal region were lost due to the earthquake, the complementary network of 2) and 3) yielded better precipitation estimates. The data clarified that snowfall was observed on the night of Mar 15 into the morning of Mar 16 throughout Fukushima prefecture. This had an important effect on the radioactive contamination pattern in Fukushima prefecture. The precipitation pattern itself does not show one-on-one correspondence with the contamination pattern. While the pollutants transported northeast of the NPP and through north Kanto (about 200 km southwest of Fukushima and, 100 km north of Tokyo) went to the northwest, the timing of the precipitation causing the fallout, i.e., wet-deposition, is important. Although the hourly Radar-AMeDAS 1-km-mesh precipitation data of JMA are available publically, it does not represent the precipitation pattern in Nakadori, in central Fukushima prefecture. Hence, we used 10-minute interval X-band radar, located in north Nakadori to determine the start and detailed horizontal pattern (120-m mesh) of the precipitation. Since 1) and 3) are 10-minute intervals and 2) is hourly data, we are developing hourly gridded data and using 1-3) to verify and quantify the rain rate observed by the Fukushima University X-band data.

"High" motivation for alcohol: what are the practical effects of energy drinks on alcohol priming?

PubMed

Peacock, Amy; Bruno, Raimondo

2013-02-01

While several researchers have proposed a causal relationship between alcohol mixed with energy drink (AmED) consumption and subsequent alcohol intake, there is a dearth of research exploring the potential mechanisms underpinning this association. Marczinski and colleagues (in press) report the results of a double-blind, placebo-controlled, between-groups study assessing whether an initial AmED dose primes an increased motivation to drink relative to alcohol alone. Participants (n = 80) received either alcohol (0.91 ml/kg vodka), energy drink (ED; 1.82 ml/kg Red Bull(®) ), AmED, or a placebo beverage and then self-reported their motivation to drink via the Desire-for-Drug scale. Subjective ratings of "desire more alcohol" were significantly higher than predrink in the placebo, alcohol, and AmED conditions, with this effect apparent at more time points in the AmED condition. While it was concluded that EDs may increase alcohol priming, between-condition analyses revealed that ratings did not differ significantly in AmED and alcohol conditions, with moderate magnitude treatment effects at most, and ratings of desire generally closer to 0 (absence of desire) than 100 (very much desire). While the study by Marczinski and colleagues fills an important gap in the literature, direct measurement of AmED priming's effect on subsequent alcohol consumption using a within-subjects design and appropriate statistical comparison is required to (i) establish the practical implications of these results for AmED consumers and (ii) discount any individual differences in such priming effects. Copyright © 2012 by the Research Society on Alcoholism.

Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 deficiency.

PubMed

Yau, Mabel; Haider, Shozeb; Khattab, Ahmed; Ling, Chen; Mathew, Mehr; Zaidi, Samir; Bloch, Madison; Patel, Monica; Ewert, Sinead; Abdullah, Wafa; Toygar, Aysenur; Mudryi, Vitalii; Al Badi, Maryam; Alzubdi, Mouch; Wilson, Robert C; Al Azkawi, Hanan Said; Ozdemir, Hatice Nur; Abu-Amer, Wahid; Hertecant, Jozef; Razzaghy-Azar, Maryam; Funder, John W; Al Senani, Aisha; Sun, Li; Kim, Se-Min; Yuen, Tony; Zaidi, Mone; New, Maria I

2017-12-26

Mutations in 11β-hydroxysteroid dehydrogenase type 2 gene ( HSD11B2 ) cause an extraordinarily rare autosomal recessive disorder, apparent mineralocorticoid excess (AME). AME is a form of low renin hypertension that is potentially fatal if untreated. Mutations in the HSD11B2 gene result either in severe AME or a milder phenotype (type 2 AME). To date, ∼40 causative mutations have been identified. As part of the International Consortium for Rare Steroid Disorders, we have diagnosed and followed the largest single worldwide cohort of 36 AME patients. Here, we present the genotype and clinical phenotype of these patients, prominently from consanguineous marriages in the Middle East, who display profound hypertension and hypokalemic alkalosis. To correlate mutations with phenotypic severity, we constructed a computational model of the HSD11B2 protein. Having used a similar strategy for the in silico evaluation of 150 mutations of CYP21A2 , the disease-causing gene in congenital adrenal hyperplasia, we now provide a full structural explanation for the clinical severity of AME resulting from each known HSD11B2 missense mutation. We find that mutations that allow the formation of an inactive dimer, alter substrate/coenzyme binding, or impair structural stability of HSD11B2 yield severe AME. In contrast, mutations that cause an indirect disruption of substrate binding or mildly alter intramolecular interactions result in type 2 AME. A simple in silico evaluation of novel missense mutations could help predict the often-diverse phenotypes of an extremely rare monogenic disorder.

The AME2016 atomic mass evaluation (I). Evaluation of input data; and adjustment procedures

NASA Astrophysics Data System (ADS)

Huang, W. J.; Audi, G.; Wang, Meng; Kondev, F. G.; Naimi, S.; Xu, Xing

2017-03-01

This paper is the first of two articles (Part I and Part II) that presents the results of the new atomic mass evaluation, AME2016. It includes complete information on the experimental input data (also including unused and rejected ones), as well as details on the evaluation procedures used to derive the tables of recommended values given in the second part. This article describes the evaluation philosophy and procedures that were implemented in the selection of specific nuclear reaction, decay and mass-spectrometric results. These input values were entered in the least-squares adjustment for determining the best values for the atomic masses and their uncertainties. Details of the calculation and particularities of the AME are then described. All accepted and rejected data, including outweighted ones, are presented in a tabular format and compared with the adjusted values obtained using the least-squares fit analysis. Differences with the previous AME2012 evaluation are discussed and specific information is presented for several cases that may be of interest to AME users. The second AME2016 article gives a table with the recommended values of atomic masses, as well as tables and graphs of derived quantities, along with the list of references used in both the AME2016 and the NUBASE2016 evaluations (the first paper in this issue). AMDC: http://amdc.impcas.ac.cn/ Contents The AME2016 atomic mass evaluation (I). Evaluation of input data; and adjustment proceduresAcrobat PDF (1.2 MB) Table I. Input data compared with adjusted valuesAcrobat PDF (1.3 MB)

ARC-2010-ACD10-0123-001

NASA Image and Video Library

2010-06-24

Park Avenue Elementary Teachers Visit / Thank You for Donation of Computers. From left to right are Dennis Wingo, Skycorp, Damon Reid, Property Disposal Officer NASA Ames, Andy Dominguez, Property Disposal Specialist NASA Ames, Kenneth Zin, PKZ Corp. Pete Worden, Director, NASA Ames Research Center, Sergio Torres, Vice Principle Park Avenue Elementary, unkown, Betty Maxwell, Speech Languare Pathologist.

Characteristics of University Students Who Mix Alcohol and Energy Drinks

ERIC Educational Resources Information Center

Bonar, Erin E.; Green, Michaela R.; Ashrafioun, Lisham

2017-01-01

Objective: Research has identified correlates (e.g., drug use, risky sex, smoking) of using alcohol mixed with energy drinks (AMEDs). Few studies have investigated common mental health-related concerns (e.g., depression, sleep). Participants: Alcohol-using college students (n = 380 never used AMEDs, n = 180 used AMEDs) were recruited in the study…

The Alternaria alternata Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation

PubMed Central

Grover, Shivani; Lawrence, Christopher B.

2017-01-01

The Alternaria mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) have been shown to possess genotoxic and cytotoxic properties. In this study, the ability of AOH and AME to modulate innate immunity in the human bronchial epithelial cell line (BEAS-2B) and mouse macrophage cell line (RAW264.7) were investigated. During these studies, it was discovered that AOH and to a lesser extent AME potently suppressed lipopolysaccharide (LPS)-induced innate immune responses in a dose-dependent manner. Treatment of BEAS-2B cells with AOH resulted in morphological changes including a detached pattern of growth as well as elongated arms. AOH/AME-related immune suppression and morphological changes were linked to the ability of these mycotoxins to cause cell cycle arrest at the G2/M phase. This model was also used to investigate the AOH/AME mechanism of immune suppression in relation to aryl hydrocarbon receptor (AhR). AhR was not found to be important for the immunosuppressive properties of AOH/AME, but appeared important for the low levels of cell death observed in BEAS-2B cells. PMID:28726766

Alcohol Mixed with Energy Drink Use as an Event-Level Predictor of Physical and Verbal Aggression in Bar Conflicts.

PubMed

Miller, Kathleen E; Quigley, Brian M; Eliseo-Arras, Rebecca K; Ball, Natalie J

2016-01-01

Young adult use of alcohol mixed with caffeinated energy drinks (AmEDs) has been globally linked with increased odds of interpersonal aggression, compared with the use of alcohol alone. However, no prior research has linked these behaviors at the event level in bar drinking situations. The present study assessed whether AmED use is associated with the perpetration of verbal and physical aggression in bar conflicts at the event level. In Fall 2014, a community sample of 175 young adult AmED users (55% female) completed a web survey describing a recent conflict experienced while drinking in a bar. Use of both AmED and non-AmED alcoholic drinks in the incident were assessed, allowing calculation of our main predictor variable, the proportion of AmEDs consumed (AmED/total drinks consumed). To measure perpetration of aggression, participants reported on the occurrence of 6 verbal and 6 physical acts during the bar conflict incident. Linear regression analyses showed that the proportion of AmEDs consumed predicted scores for perpetration of both verbal aggression (β = 0.16, p < 0.05) and physical aggression (β = 0.19, p < 0.01) after controlling for gender, age, sensation-seeking and aggressive personality traits, aggressive alcohol expectancies, aggressogenic physical and social bar environments, and total number of drinks. Results of this study suggest that in alcohol-related bar conflicts, higher levels of young adult AmED use are associated with higher levels of aggression perpetration than alcohol use alone and that the elevated risk is not attributable to individual differences between AmED users and nonusers or to contextual differences in bar drinking settings. While future research is needed to identify motivations, dosages, and sequencing issues associated with AmED use, these beverages should be considered a potential risk factor in the escalation of aggressive bar conflicts. Copyright © 2016 by the Research Society on Alcoholism.

ARC-2008-ACD08-0205-060

NASA Image and Video Library

2008-09-16

NASA's 50th Anniversay year. Panel discussion with four of NASA AMES's past center directors on how their tenure effected Ames and NASA. On the projects they pushed for and/or pushed forward and the culture of the center and the agency and how that worked for or against Ames, as well as major contributions of the time made by Ames Research Center. Panel L-R; Hans Mark, Sy Syvertson, Dale Compton, Scott Hubbard and Pete Worden, present director. (Past Directors served for periods from 1969 thru 2006) at a round table in the Boyd Room of N-200.

NASA Ames Research Center Overview

NASA Technical Reports Server (NTRS)

Boyd, Jack

2006-01-01

A general overview of the NASA Ames Research Center is presented. The topics include: 1) First Century of Flight, 1903-2003; 2) NACA Research Centers; 3) 65 Years of Innovation; 4) Ames Projects; 5) NASA Ames Research Center Today-founded; 6) Astrobiology; 7) SOFIA; 8) To Explore the Universe and Search for Life: Kepler: The Search for Habitable Planets; 9) Crew Exploration Vehicle/Crew Launch Vehicle; 10) Lunar Crater Observation and Sensing Satellite (LCROSS); 11) Thermal Protection Materials and Arc-Jet Facility; 12) Information Science & Technology; 13) Project Columbia Integration and Installation; 14) Air Traffic Management/Air Traffic Control; and 15) New Models-UARC.

The role of symmetry in neural networks and their Laplacian spectra.

PubMed

de Lange, Siemon C; van den Heuvel, Martijn P; de Reus, Marcel A

2016-11-01

Human and animal nervous systems constitute complexly wired networks that form the infrastructure for neural processing and integration of information. The organization of these neural networks can be analyzed using the so-called Laplacian spectrum, providing a mathematical tool to produce systems-level network fingerprints. In this article, we examine a characteristic central peak in the spectrum of neural networks, including anatomical brain network maps of the mouse, cat and macaque, as well as anatomical and functional network maps of human brain connectivity. We link the occurrence of this central peak to the level of symmetry in neural networks, an intriguing aspect of network organization resulting from network elements that exhibit similar wiring patterns. Specifically, we propose a measure to capture the global level of symmetry of a network and show that, for both empirical networks and network models, the height of the main peak in the Laplacian spectrum is strongly related to node symmetry in the underlying network. Moreover, examination of spectra of duplication-based model networks shows that neural spectra are best approximated using a trade-off between duplication and diversification. Taken together, our results facilitate a better understanding of neural network spectra and the importance of symmetry in neural networks. Copyright © 2016 Elsevier Inc. All rights reserved.

The AME2016 atomic mass evaluation (I). Evaluation of input data; and adjustment procedures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, W. J.; Audi, G.; Wang, Meng

This paper is the first of two articles (Part I and Part II) that presents the results of the new atomic mass evaluation, Ame2016. It includes complete information on the experimental input data (also including unused and rejected ones), as well as details on the evaluation procedures used to derive the tables of recommended values given in the second part. This article describes the evaluation philosophy and procedures that were implemented in the selection of specific nuclear reaction, decay and mass-spectrometric results. These input values were entered in the least-squares adjustment for determining the best values for the atomic massesmore » and their uncertainties. Details of the calculation and particularities of the Ame are then described. All accepted and rejected data, including outweighted ones, are presented in a tabular format and compared with the adjusted values obtained using the least-squares fit analysis. Differences with the previous Ame2012 evaluation are discussed and specific information is presented for several cases that may be of interest to Ame users. The second Ame2016 article gives a table with the recommended values of atomic masses, as well as tables and graphs of derived quantities, along with the list of references used in both the Ame2016 and the Nubase2016 evaluations (the first paper in this issue). Amdc: http://amdc.impcas.ac.cn/« less

The effects of alcohol mixed with energy drink (AMED) on subjective intoxication and alertness: results from a double-blind placebo-controlled clinical trial.

PubMed

van de Loo, Aurora J A E; van Andel, Nienke; van Gelder, Charlotte A G H; Janssen, Boris S G; Titulaer, Joep; Jansen, Jimmy; Verster, Joris C

2016-05-01

The purpose of this double blind placebo controlled study was to examine if specific effects on subjective intoxication and alertness-sleepiness ratings could be demonstrated after consuming alcohol mixed with energy drink (AMED) when compared to consuming alcohol only (AO). 56 healthy volunteers rated their subjective intoxication on a scale ranging from 0 (sober) to 10 (highly intoxicated) at baseline, breath alcohol concentration (BAC) of 0%, and at BAC 0.08%, 0.05%, and 0.02%. Alertness-sleepiness was assessed with the Karolinska sleepiness scale. Scores of the AMED and AO condition, at each BAC level, were compared. Subjective intoxication for AMED and AO did not differ significantly from each other at any BAC level, except for BAC 0.02%. A significant increase in sleepiness scores was found in the AO condition, whereas scores remained stable in the AMED condition. Sleepiness scores at BAC0.08% and 0.05% were significantly lower after AMED when compared to AO. However, the observed differences between AMED and AO were small and have no clinical relevance. Mixing alcohol with energy drink had no overall masking effect on subjective intoxication caused by alcohol, nor had a relevant effect on subjective alertness-sleepiness ratings. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension.

PubMed

Cebova, Martina; Klimentova, Jana; Janega, Pavol; Pechanova, Olga

2017-01-01

Aronia melanocarpa has attracted scientific interest due to its dense contents of different polyphenols. We aimed to analyse effects of Aronia melanocarpa (AME) extract on blood pressure (BP), lipid peroxidation, cytokine level, total NOS activity in the left ventricle (LV), and aorta of L-NAME-induced hypertensive rats. 12-week-old male WKY rats were assigned to the control group and groups treated with AME extract (57.90 mg/kg/day), L-NAME (40 mg/kg/day), or combination of L-NAME (40 mg/kg/day) and AME (57.90 mg/kg/day) in tap water for 3 weeks. NOS activity, eNOS protein expression, and conjugated diene (CD) concentration were determined in the LV and aorta. After 3 weeks of L-NAME treatment, BP was increased by 28% and concomitant treatment with AME reduced it by 21%. NOS activity of the LV and aorta in the L-NAME group was decreased by about 40%, while AME increased it almost on the control level. AME-induced eNOS upregulation may contribute to increase NOS activity. Moreover, AME decreased CD concentration in the LV and aorta and TNF- α and IL-6 production in the plasma were increased by L-NAME treatment. In conclusion, our results showed that active substances of Aronia melanocarpa may have a positive effect on blood pressure, NOS activity, and proinflammatory processes in L-NAME-induced hypertension.

The spinal control of locomotion and step-to-step variability in left-right symmetry from slow to moderate speeds

PubMed Central

Dambreville, Charline; Labarre, Audrey; Thibaudier, Yann; Hurteau, Marie-France

2015-01-01

When speed changes during locomotion, both temporal and spatial parameters of the pattern must adjust. Moreover, at slow speeds the step-to-step pattern becomes increasingly variable. The objectives of the present study were to assess if the spinal locomotor network adjusts both temporal and spatial parameters from slow to moderate stepping speeds and to determine if it contributes to step-to-step variability in left-right symmetry observed at slow speeds. To determine the role of the spinal locomotor network, the spinal cord of 6 adult cats was transected (spinalized) at low thoracic levels and the cats were trained to recover hindlimb locomotion. Cats were implanted with electrodes to chronically record electromyography (EMG) in several hindlimb muscles. Experiments began once a stable hindlimb locomotor pattern emerged. During experiments, EMG and bilateral video recordings were made during treadmill locomotion from 0.1 to 0.4 m/s in 0.05 m/s increments. Cycle and stance durations significantly decreased with increasing speed, whereas swing duration remained unaffected. Extensor burst duration significantly decreased with increasing speed, whereas sartorius burst duration remained unchanged. Stride length, step length, and the relative distance of the paw at stance offset significantly increased with increasing speed, whereas the relative distance at stance onset and both the temporal and spatial phasing between hindlimbs were unaffected. Both temporal and spatial step-to-step left-right asymmetry decreased with increasing speed. Therefore, the spinal cord is capable of adjusting both temporal and spatial parameters during treadmill locomotion, and it is responsible, at least in part, for the step-to-step variability in left-right symmetry observed at slow speeds. PMID:26084910

Giving E-Commerce a Boost

NASA Technical Reports Server (NTRS)

2000-01-01

A former Ames employee, Monte Zweben, founded a new company, Blue Martini Software, that provides software to companies seeking to personalize their products to individual customers. This customer targeting approach is accomplished through the use of artificial intelligence concepts Zweben worked on while at Ames. The Ames AI research has found applications in clickstream mining and purchasing behavior data collection.

Aerodynamic Characteristics of SC1095 and SC1094 R8 Airfoils

DTIC Science & Technology

2003-12-01

Development, and Engineering Command Ames Research Center Moffett Field, California December 2003 National Aeronautics and Space Administration Ames...60A ROTOR BLADE AND AIRFOILS ................................................................................... 2 EVALUATION OF SECTION CHARACTERISTICS...Characteristics of SC1095 and SC1094 R8 Airfoils WILLIAM G. BOUSMAN Aeroflightdynamics Directorate U.S. Army Research, Development, and Engineering Command Ames

ARC-2010-ACD10-0244-003

NASA Image and Video Library

2010-10-18

From left, Giovanni Minelli with the NASA's Ames Research Center; Center: Kitty Sedam with Aerospace Corp.; and Charlie Friedericks with Ames inspect the packing list and instructions for the Ames-managed O/OREOS and NanoSail-D from NASA's Marshall Space Flgith Center nano satellites at Kodiak Launch Complex, Alaska . Image credit: U.S. Air Force/Lou Hernandez

Intoxication-Related AmED (Alcohol Mixed with Energy Drink) Expectancies Scale: Initial Development and Validation

PubMed Central

Miller, Kathleen E.; Dermen, Kurt H.; Lucke, Joseph F.

2017-01-01

BACKGROUND Young adult use of alcohol mixed with energy drinks (AmEDs) has been linked with elevated risks for a constellation of problem behaviors. These risks may be conditioned by expectancies regarding the effects of caffeine in conjunction with alcohol consumption. The aim of this study was to describe the construction and psychometric evaluation of the Intoxication-Related AmED Expectancies Scale (AmED_EXPI), 15 self-report items measuring beliefs about how the experience of AmED intoxication differs from the experience of noncaffeinated alcohol (NCA) intoxication. METHODS Scale development and testing were conducted using data from a U.S. national sample of 3,105 adolescents and emerging adults aged 13–25. Exploratory and confirmatory factor analyses were conducted to evaluate the factor structure and establish factor invariance across gender, age, and prior experience with AmED use. Cross-sectional and longitudinal analyses examining correlates of AmED use were used to assess construct and predictive validity. RESULTS In confirmatory factor analyses, fit indices for the hypothesized four-factor structure (i.e., Intoxication Management [IM], Alertness [AL], Sociability [SO], and Jitters [JT]) revealed a moderately good fit to the data. Together, these factors accounted for 75.3% of total variance. The factor structure was stable across male/female, teen/young adult, and AmED experience/no experience subgroups. The resultant unit-weighted subscales showed strong internal consistency and satisfactory convergent validity. Baseline scores on the IM, SO, and JT subscales predicted changes in AmED use over a subsequent three-month period. CONCLUSIONS The AmED_EXPI appears to be a reliable and valid tool for measuring expectancies about the effects of caffeine during alcohol intoxication. PMID:28421613

Correlates of use of alcohol mixed with energy drinks among youth across 10 US metropolitan areas.

PubMed

Khan, Shivani R; Cottler, Linda B; Striley, Catherine W

2016-06-01

Predictors of use of alcohol mixed with energy drinks (AmED) among youth have been understudied. The current analyses investigated the prevalence of and correlates for use of AmED among alcohol users from a national study of stimulant use among youth. The National Monitoring of Adolescent Prescription Stimulants Study (N-MAPSS) assessed behaviors and risk factors for stimulant use from 11,048 youth, 10-18 years of age recruited from entertainment venues across 10 US cities. Of the four cross sections, two had questions on having alcohol mixed with energy drinks (AmED) in the past 30 days along with sociodemographic characteristics, current tobacco and marijuana use and current nonmedical use of prescription opioids, anxiolytics, and stimulants. Only 13 to18 year olds and those who reported alcohol use were included in the analyses. Overall, 28.4% (1392 out of 4905) of the 13 to18 year olds reported past 30-day alcohol use. Among alcohol users, 27% reported having alcohol mixed with energy drinks in the past 30 days. Multivariate logistic regression indicated that use of AmED was significantly associated with tobacco and marijuana use and nonmedical use of prescription stimulants. Underage drinking is common among youth and more than a quarter of these drinkers use AmED. Use of AmED is significantly associated with tobacco and marijuana use and nonmedical use of prescription stimulants. Drug and alcohol intervention programs should educate on the risks of AmED, as the same population is at high-risk for use of AmED and alcohol/drug use. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The multiplicative effect of combining alcohol with energy drinks on adolescent gambling.

PubMed

Vieno, Alessio; Canale, Natale; Potente, Roberta; Scalese, Marco; Griffiths, Mark D; Molinaro, Sabrina

2018-07-01

There has been increased concern about the negative effects of adolescents consuming a combination of alcohol mixed with energy drinks (AmED). To date, few studies have focused on AmED use and gambling. The present study analyzed the multiplicative effect of AmED consumption, compared to alcohol alone, on the likelihood of at-risk or problem gambling during adolescence. Data from the ESPAD®Italia 2015 study, a cross-sectional survey conducted in a nationally representative sample of students (ages 15 to 19years) were used to examine the association between self-reported AmED use (≥6 times,≥10 times, and ≥20 times during the last month) and self-reported gambling severity. Multivariate models were used to calculate adjusted prevalence ratios to evaluate the association between alcohol use, AmED use, and gambling among a representative sample of adolescents who reported gambling in the last year and completed a gambling severity scale (n=4495). Among the 19% students classed as at-risk and problem gamblers, 43.9% were classed as AmED consumers, while 23.6% were classed as alcohol consumers (i.e. did not mix alcohol with energy drinks). In multivariate analyses that controlled for covariates, AmED consumers were three times more likely to be at-risk and problem gamblers (OR=3.05) compared to non-consuming adolescents, while the effect became less pronounced with considering those who consumed alcohol without the addition of energy drinks (OR=1.37). The present study clearly established that consuming AmED might pose a significantly greater risk of experiencing gambling-related problems among adolescents. Copyright © 2018 Elsevier Ltd. All rights reserved.

Energy Drink and Alcohol mixed Energy Drink use among high school adolescents: Association with risk taking behavior, social characteristics.

PubMed

Scalese, Marco; Denoth, Francesca; Siciliano, Valeria; Bastiani, Luca; Cotichini, Rodolfo; Cutilli, Arianna; Molinaro, Sabrina

2017-09-01

The aims of the study were to: a) examine the prevalence of energy drink (ED) and alcohol mixed with energy drink (AmED) consumption; b) investigate the relationships between ED and AmED with alcohol, binge drinking and drugs accounting for at risk behaviors among a representative sample of Italian adolescents. A representative sample of 30,588 Italian high school students, aged 15-19years, was studied. Binary and multivariate logistic regression analyses were performed to determine the independent association of the potential predictors' characteristics with the ED and AmED drinking during the last year. Respectively 41.4% and 23.2% of respondents reported drinking EDs and AmEDs in the last year. Multivariate analysis revealed that consumption of EDs and AmEDs during the last year were significantly associated with daily smoking, binge drinking, use of cannabis and other psychotropic drugs. Among life habits and risky behaviors the following were positively associated: going out with friends for fun, participating in sports, experiencing physical fights/accidents or injury, engaging in sexual intercourse without protection and being involved in accidents while driving. This study demonstrates the popularity of ED and AmED consumption among the Italian school population aged 15-19years old: 4 out of 10 students consumed EDs in the last year and 2 out of 10 AmED. Multivariate analysis highlighted the association with illicit drug consumption and harming behaviors, confirming that consumption of EDs and AmEDs is a compelling issue especially during adolescence, as it can effect health as well as risk taking behaviors. Copyright © 2017 Elsevier Ltd. All rights reserved.

The effects of alcohol mixed with energy drinks (AmED) on traffic behaviors among Brazilian college students: a national survey.

PubMed

Eckschmidt, Frederico; de Andrade, Arthur Guerra; dos Santos, Bernardo; de Oliveira, Lúcio Garcia

2013-01-01

Drinking alcohol mixed with energy drinks (AmED) may be contributing to hazardous drinking practices and risk-taking behaviors among college students. In this regard, this study aimed to assess the frequency of AmED consumption in a national sample of Brazilian college students and to estimate the risk that energy drinks pose on drinking and traffic behaviors. A sample of 12,711 college students from across the country was asked to complete a research questionnaire on the use of drugs and other behaviors. Students who reported drinking in the previous 12 months (N = 8672) were divided into 2 groups: (a) those who reported drinking only alcohol (N = 4192) and (b) those who reported drinking AmED (N = 1119). The college students who reported the use of at least one illicit drug were excluded from data analysis. Descriptive and inferential analyses were subsequently carried out using the R library survey software 2.15.0. The null hypothesis was rejected at the level of P < .05. AmED users are more likely to be hazardous drinkers. Being male, single, and involved with high-risk drinking behaviors are associated to AmED. After adjusting for demographic and drinking variables, the odds of being involved in high-risk traffic behaviors--for example, driving at high speed (odds ratio [OR] = 2.6; P < .001) and driving after binge drinking (OR = 2.8; P < .001)--were higher among AmED users than alcohol only users (AUs). The current findings are consistent with the results of previous studies. Drinking AmED may make college students more vulnerable to the occurrence of risky drinking and traffic behaviors. Educational campaigns targeted to young people should be developed warning them about the potential risks of mixing alcohol with energy drinks.

Driving under the influence behaviours among high school students who mix alcohol with energy drinks.

PubMed

Wilson, Maria N; Cumming, Tammy; Burkhalter, Robin; Langille, Donald B; Ogilvie, Rachel; Asbridge, Mark

2018-06-01

Alcohol and energy drinks are commonly used substances by youth in Canada, and are often mixed (AmED). While several studies have shown that AmED can have dangerous effects, less well understood is how AmED is associated with driving under the influence of either alcohol or drugs. This study sought to determine whether youth who use AmED were more likely to engage in driving, or being a passenger of a driver, under the influence of alcohol or cannabis compared to youth who use either alcohol or energy drinks alone. This study used data from grade 10-12 students who took part in the 2014/2015 Canadian Student Tobacco, Alcohol and Drugs Survey (N=17,450). The association of past-year AmED use with past-30day: driving under the influence of alcohol or cannabis, and riding with an alcohol- or cannabis-influenced driver, was assessed using logistic regression. One in four youth had consumed AmED in the previous 12months. AmED users were more likely to engage in all risk behaviours except riding with a drinking driver, relative to youth who only consumed alcohol. No association was observed for youth who consumed alcohol and energy drinks on separate occasions. Youth who use AmED demonstrate a higher risk profile for driving under the influence of alcohol or cannabis, than youth who use alcohol alone. Future research should explore the biopsychosocial pathways that may explain why using energy drinks enhances the already heightened risk posed by alcohol on other health-related behaviours such as driving under the influence. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Making Stuff Outreach at the Ames Laboratory and Iowa State University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ament, Katherine; Karsjen, Steven; Leshem-Ackerman, Adah

The U. S. Department of Energy's Ames Laboratory in Ames, Iowa was a coalition partner for outreach activities connected with NOVA's Making Stuff television series on PBS. Volunteers affiliated with the Ames Laboratory and Iowa State University, with backgrounds in materials science, took part in activities including a science-themed Family Night at a local mall, Science Cafes at the Science Center of Iowa, teacher workshops, demonstrations at science nights in elementary and middle schools, and various other events. We describe a selection of the activities and present a summary of their outcomes and extent of their impact on Ames, Desmore » Moines and the surrounding communities in Iowa. In Part 2, results of a volunteer attitude survey are presented, which shed some light on the volunteer experience and show how the volunteers participation in outreach activities has affected their views of materials education.« less

Ames Fitness Program

NASA Technical Reports Server (NTRS)

Pratt, Randy

1993-01-01

The Ames Fitness Program services 5,000 civil servants and contractors working at Ames Research Center. A 3,000 square foot fitness center, equipped with cardiovascular machines, weight training machines, and free weight equipment is on site. Thirty exercise classes are held each week at the Center. A weight loss program is offered, including individual exercise prescriptions, fitness testing, and organized monthly runs. The Fitness Center is staffed by one full-time program coordinator and 15 hours per week of part-time help. Membership is available to all employees at Ames at no charge, and there are no fees for participation in any of the program activities. Prior to using the Center, employees must obtain a physical examination and complete a membership package. Funding for the Ames Fitness Program was in jeopardy in December 1992; however, the employees circulated a petition in support of the program and collected more than 1500 signatures in only three days. Funding has been approved through October 1993.

Analysis of Returned Comet Nucleus Samples

NASA Astrophysics Data System (ADS)

Chang, Sherwood

1997-12-01

This volume contains abstracts that have been accepted by the Program Committee for presentation at the Workshop on Analysis of Returned Comet Nucleus Samples, held in Milpitas, California, January 16-18, 1989. Conveners are Sherwood Chang (NASA Ames Research Center) and Larry Nyquist (NASA Johnson Space Center). Program Committee members are Thomas Ahrens (ex-officio; California Institute of Technology), Lou Allamandola (NASA Ames Research Center), David Blake (NASA Ames Research Center), Donald Brownlee (University of Washington, Seattle), Theodore E. Bunch (NASA Ames Research Center), Humberto Campins (Planetary Science Institute), Jeff Cuzzi (NASA Ames Research Center), Eberhard Griin (Max-Plank-Institut fiir Kemphysik), Martha Hanner (Jet Propulsion Laboratory), Alan Harris (Jet Propulsion Laboratory), John Kerrid-e (University of Califomia, Los Angeles), Yves Langevin (University of Paris), Gerhard Schwehm (ESTEC), and Paul Weissman (Jet Propulsion Laboratory). Logistics and administrative support for the workshop were provided by the Lunar and Planetary Institute Projects Office.

Analysis of Returned Comet Nucleus Samples

NASA Technical Reports Server (NTRS)

Chang, Sherwood (Compiler)

1997-01-01

This volume contains abstracts that have been accepted by the Program Committee for presentation at the Workshop on Analysis of Returned Comet Nucleus Samples, held in Milpitas, California, January 16-18, 1989. Conveners are Sherwood Chang (NASA Ames Research Center) and Larry Nyquist (NASA Johnson Space Center). Program Committee members are Thomas Ahrens (ex-officio; California Institute of Technology), Lou Allamandola (NASA Ames Research Center), David Blake (NASA Ames Research Center), Donald Brownlee (University of Washington, Seattle), Theodore E. Bunch (NASA Ames Research Center), Humberto Campins (Planetary Science Institute), Jeff Cuzzi (NASA Ames Research Center), Eberhard Griin (Max-Plank-Institut fiir Kemphysik), Martha Hanner (Jet Propulsion Laboratory), Alan Harris (Jet Propulsion Laboratory), John Kerrid-e (University of Califomia, Los Angeles), Yves Langevin (University of Paris), Gerhard Schwehm (ESTEC), and Paul Weissman (Jet Propulsion Laboratory). Logistics and administrative support for the workshop were provided by the Lunar and Planetary Institute Projects Office.

Ames Research Center Research and Technology 2000

NASA Technical Reports Server (NTRS)

2002-01-01

This report highlights the challenging work accomplished during fiscal year 2000 by Ames research scientists,engineers, and technologists. It discusses research and technologies that enable the Information Age, that expand the frontiers of knowledge for aeronautics and space, and that help to maintain U.S. leadership in aeronautics and space research and technology development. The accomplishments are grouped into four categories based on four of NASA's Strategic Enterprises: Aerospace Technology, Space Science, Biological and Physical Research, and Earth Science. The primary purpose of this report is to communicate knowledge-to inform our stakeholders, customer, and partners, and the people of the United States about the scope and diversity of Ames' mission,the nature of Ames' research and technolog) activities,and the stimulating challenges ahead. The accomplishments cited illustrate the contributions that Ames is willing to improve the quality of life for our citizens and the economic position of the United States in the world marketplace.

Status epilepticus in dogs and cats, part 1: etiopathogenesis, epidemiology, and diagnosis.

PubMed

Blades Golubovic, Susan; Rossmeisl, John H

2017-05-01

To review current knowledge of the etiopathogenesis, diagnosis, and consequences of status epilepticus (SE) in veterinary patients. Human and veterinary literature, including clinical and laboratory research and reviews. Status epilepticus is a common emergency in dogs and cats, and may be the first manifestation of a seizure disorder. It results from the failure of termination of an isolated seizure. Multiple factors are involved in SE, including initiation and maintenance of neuronal excitability, neuronal network synchronization, and brain microenvironmental contributions to ictogenesis. Underlying etiologies of epilepsy and SE in dogs and cats are generally classified as genetic (idiopathic), structural-metabolic, or unknown. Diagnosis of convulsive SE is usually made based on historical information and the nature of the seizures. Patient specific variables, such as the history, age of seizure onset, and physical and interictal neurological examination findings can help hone the rule out list, and are used to guide selection and prioritization of diagnostic tests. Electroencephalographic monitoring is routinely used in people to diagnose SE and guide patient care decisions, but is infrequently performed in veterinary medicine. Nonconvulsive status epilepticus has been recognized in veterinary patients; routine electroencephalography would aid in the diagnosis of this phenomenon in dogs and cats. Status epilepticus is a medical emergency that can result in life-threatening complications involving the brain and systemic organs. Status epilepticus often requires comprehensive diagnostic testing, treatment with multiple anticonvulsant agents, and intensive supportive care. © Veterinary Emergency and Critical Care Society 2017.

NASA Ames Research Center Air Traffic Management Research Overview

NASA Technical Reports Server (NTRS)

Lozito, Sandy

2017-01-01

This is a presentation to the Owl Feather Society, a group of people who are retired from NASA Ames Research Center. I am providing a summary of the ATM research here at NASA Ames to this group as part of a lunch time talk series. The presentation will be at Michael's Restaurant in Mountain View, CA on July 18.

Aviation Structural Mechanic E 3 & 2. Rate Training Manual.

ERIC Educational Resources Information Center

Naval Training Publications Center, Memphis, TN.

This manual is one of a series of training manuals prepared for enlisted personnel in the Navy and Naval Reserve who are studying for advancement according to the Aviation Structural Mechanic E (AME) rating. The text is based on the professional qualifications for the rates AME3 and AME2. Contents include a 10-chapter text and a reading list…

ARC-1958-A-23928

NASA Image and Video Library

1958-05-21

NACA Photographer Thrust reverser on F-94C-1 (AF50-956 NACA 156) Starfire (l to R) Air Force Major E. Sommerich; Ames Engineer Seth Anderson, Lt. Col. Tavasti; and Ames Chief test pilot George Cooper discussing phases of flight evaluation tests. Note: Used in publication in Flight Research at Ames; 57 Years of Development and Validation of Aeronautical Technology NASA SP-1998-3300 fig 91

Briefing to University of Porto on NASA Airborne Science Program and Ames UAVs

NASA Technical Reports Server (NTRS)

Fladeland, Matthew

2015-01-01

NASA Ames is exploring a partnership with the University of Portugal to jointly develop and test new autonomous vehicle technologies. As part of the discussions I will be briefing the University of Portugal faculty on the NASA Airborne Science Program (ASP) and associated activities at NASA Ames Research Center. The presentation will communicate the requirements that drive the program, the assets available to NASA researchers, and discuss research projects that have used unmanned aircraft systems including MIZOPEX, Surprise Valley, and Florida Keys Coral Reef assessment. Other topics will include the SIERRA and Dragon Eye UAV projects operated at Ames.

Optimal quantum error correcting codes from absolutely maximally entangled states

NASA Astrophysics Data System (ADS)

Raissi, Zahra; Gogolin, Christian; Riera, Arnau; Acín, Antonio

2018-02-01

Absolutely maximally entangled (AME) states are pure multi-partite generalizations of the bipartite maximally entangled states with the property that all reduced states of at most half the system size are in the maximally mixed state. AME states are of interest for multipartite teleportation and quantum secret sharing and have recently found new applications in the context of high-energy physics in toy models realizing the AdS/CFT-correspondence. We work out in detail the connection between AME states of minimal support and classical maximum distance separable (MDS) error correcting codes and, in particular, provide explicit closed form expressions for AME states of n parties with local dimension \

Alcohol Mixed With Energy Drinks and Sexually Related Causes of Conflict in the Barroom.

PubMed

Ball, Natalie J; Miller, Kathleen E; Quigley, Brian M; Eliseo-Arras, Rebecca K

2018-05-01

The popularity of alcohol mixed with energy drinks (AmED) among young adults has spurred studies that focus on its links to aggression and risk-taking behaviors, including risky sex and sexual victimization. However, no studies to date have looked at the relationship between AmED and causes of interpersonal conflict in bars at the event level. The present study evaluated whether AmED use at the time of the bar conflict was associated with greater odds that a bar conflict would be precipitated by sexually related causes. Online survey data, including a description of a recent bar conflict, were collected from a community sample of 175 young adult (97 female) AmED users age 18 to 30 in western New York state. Qualitative findings included the natural categorization of sexually related causes of conflict, consisting of unwanted sexual advances and jealousy, and the prominence of sexual competition in these conflicts. Proportion of AmED use (out of the total quantity of alcoholic drinks) predicted the odds that the bar conflict would have a sexually related cause, above and beyond control variables. How AmED use might be associated with sexual competition and conflict in the bar is discussed.

Proper expression of metabolizable energy in avian energetics

USGS Publications Warehouse

Miller, M.R.; Reinecke, K.J.

1984-01-01

We review metabolizable energy (ME) concepts and present evidence suggesting that the form of ME used for analyses of avian energetics can affect interpretation of results. Apparent ME (AME) is the most widely used measure of food energy available to birds. True ME (TME) differs from AME in recognizing fecal and urinary energy of nonfood origin as metabolized energy. Only AME values obtained from test birds fed at maintenance levels should be used for energy analyses. A practical assay for TME has shown that TME estimates are less sensitive than AME to variation in food intake. The TME assay may be particularly useful in studies of natural foods that are difficult to obtain in quantities large enough to supply test birds with maintenance requirements. Energy budgets calculated from existence metabolism should be expressed as kJ of AME and converted to food requirements with estimates of metabolizability given in kJ AME/g. Energy budgets calculated from multiples of basal metabolic rate (a component of maintenance energy), however, should be expressed as kJ of either TME or net energy depending on ambient temperature. Energy units should be stated explicitly to improve comparability and in some cases accuracy of energy analyses.

Typology of alcohol mixed with energy drink consumers: motivations for use.

PubMed

Peacock, Amy; Droste, Nicolas; Pennay, Amy; Miller, Peter; Lubman, Dan I; Bruno, Raimondo

2015-06-01

Previous research on alcohol mixed with energy drinks (AmED) has shown that use is typically driven by hedonistic, social, functional, and intoxication-related motives, with differential associations with alcohol-related harm across these constructs. There has been no research looking at whether there are subgroups of consumers based on patterns of motivations. Consequently, the aims were to determine the typology of motivations for AmED use among a community sample and to identify correlates of subgroup membership. In addition, we aimed to determine whether this structure of motivations applied to a university student sample. Data were used from an Australian community sample (n = 731) and an Australian university student sample (n = 594) who were identified as AmED consumers when completing an online survey about their alcohol and ED use. Participants reported their level of agreement with 14 motivations for AmED use; latent classes of AmED consumers were identified based on patterns of motivation endorsement using latent class analysis. A 4-class model was selected using data from the community sample: (i) taste consumers (31%): endorsed pleasurable taste; (ii) energy-seeking consumers (24%): endorsed functional and taste motives; (iii) hedonistic consumers (33%): endorse pleasure and sensation-seeking motives, as well as functional and taste motives; and (iv) intoxication-related consumers (12%): endorsed motives related to feeling in control of intoxication, as well as hedonistic, functional, and taste motives. The consumer subgroups typically did not differ on demographics, other drug use, alcohol and ED use, and AmED risk taking. The patterns of motivations for the 4-class model were similar for the university student sample. This study indicated the existence of 4 subgroups of AmED consumers based on their patterns of motivations for AmED use consistently structured across the community and university student sample. These findings lend support to the growing conceptualization of AmED consumers as a heterogeneous group in regard to motivations for use, with a hierarchical and cumulative class order in regard to the number of types of motivation for AmED use. Prospective research may endeavor to link session-specific motives and outcomes, as it is apparent that primary consumption motives may be fluid between sessions. Copyright © 2015 by the Research Society on Alcoholism.

High-Lift Optimization Design Using Neural Networks on a Multi-Element Airfoil

NASA Technical Reports Server (NTRS)

Greenman, Roxana M.; Roth, Karlin R.; Smith, Charles A. (Technical Monitor)

1998-01-01

The high-lift performance of a multi-element airfoil was optimized by using neural-net predictions that were trained using a computational data set. The numerical data was generated using a two-dimensional, incompressible, Navier-Stokes algorithm with the Spalart-Allmaras turbulence model. Because it is difficult to predict maximum lift for high-lift systems, an empirically-based maximum lift criteria was used in this study to determine both the maximum lift and the angle at which it occurs. Multiple input, single output networks were trained using the NASA Ames variation of the Levenberg-Marquardt algorithm for each of the aerodynamic coefficients (lift, drag, and moment). The artificial neural networks were integrated with a gradient-based optimizer. Using independent numerical simulations and experimental data for this high-lift configuration, it was shown that this design process successfully optimized flap deflection, gap, overlap, and angle of attack to maximize lift. Once the neural networks were trained and integrated with the optimizer, minimal additional computer resources were required to perform optimization runs with different initial conditions and parameters. Applying the neural networks within the high-lift rigging optimization process reduced the amount of computational time and resources by 83% compared with traditional gradient-based optimization procedures for multiple optimization runs.

[Promoting Research Integrity].

PubMed

Suzuki, Hiromichi

2018-01-01

　Japan Agency for Medical Research and Development (AMED) was launched in April 2015 to promote integrated medical research and development (R&D) ranging from basic research to practical applications, in order to smoothly achieve the nationwide application of research outcomes, and to establish an environment therefor. AMED consolidates budgets for R&D expenses, which had previously been allocated from different sources, such as the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labour and Welfare, and the Ministry of Economy, Trade and Industry. It provides funds strategically to universities, research institutions, etc. By promoting medical R&D, AMED aims to achieve the world's highest level of medical care/services to contribute to a society in which people live long and healthy lives. To achieve this mission, it is imperative that R&D funded by AMED is widely understood and supported. Maintaining and improving research integrity is a prerequisite to this end. AMED is taking various measures to ensure fair and appropriate R&D. It is asking researchers to participate in its responsible conduct in research (RCR) education program and to comply with its rules for managing conflicts of interest (COI). In addition, AMED also conducts a grant program to create and distribute a variety of educational materials on RCR and other matters. Further, AMED is establishing a platform that allows researchers to exchange information about research integrity, and it is undertaking additional measures, such as holding meetings and international symposia on research integrity.

Mixing an energy drink with an alcoholic beverage increases motivation for more alcohol in college students.

PubMed

Marczinski, Cecile A; Fillmore, Mark T; Henges, Amy L; Ramsey, Meagan A; Young, Chelsea R

2013-02-01

There has been a dramatic rise in the consumption of alcohol mixed with energy drinks (AmEDs) in social drinkers. It has been suggested that AmED beverages might lead individuals to drink greater quantities of alcohol. This experiment was designed to investigate whether the consumption of AmEDs would alter alcohol priming (i.e., increasing ratings of wanting another drink) compared with alcohol alone. Participants (n = 80) of equal gender attended 1 session where they were randomly assigned to receive 1 of 4 doses (0.91 ml/kg vodka, 1.82 ml/kg energy drink, 0.91 ml/kg vodka mixed with 1.82 ml/kg energy drink [AmED], or a placebo beverage). Alcohol-induced priming of the motivation to drink was assessed by self-reported ratings on the Desire for Drug questionnaire. The priming dose of alcohol increased the subjective ratings of "desire" for more alcohol, consistent with previous research that small doses of alcohol can increase the motivation to drink. Furthermore, higher desire ratings over time were observed with AmEDs compared with alcohol alone. Finally, ratings of liking the drink were similar for the alcohol and AmED conditions. An energy drink may elicit increased alcohol priming. This study provides laboratory evidence that AmED beverages may lead to greater motivation to drink versus the same amount of alcohol consumed alone. Copyright © 2012 by the Research Society on Alcoholism.

Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension

PubMed Central

Klimentova, Jana; Janega, Pavol

2017-01-01

Aronia melanocarpa has attracted scientific interest due to its dense contents of different polyphenols. We aimed to analyse effects of Aronia melanocarpa (AME) extract on blood pressure (BP), lipid peroxidation, cytokine level, total NOS activity in the left ventricle (LV), and aorta of L-NAME-induced hypertensive rats. 12-week-old male WKY rats were assigned to the control group and groups treated with AME extract (57.90 mg/kg/day), L-NAME (40 mg/kg/day), or combination of L-NAME (40 mg/kg/day) and AME (57.90 mg/kg/day) in tap water for 3 weeks. NOS activity, eNOS protein expression, and conjugated diene (CD) concentration were determined in the LV and aorta. After 3 weeks of L-NAME treatment, BP was increased by 28% and concomitant treatment with AME reduced it by 21%. NOS activity of the LV and aorta in the L-NAME group was decreased by about 40%, while AME increased it almost on the control level. AME-induced eNOS upregulation may contribute to increase NOS activity. Moreover, AME decreased CD concentration in the LV and aorta and TNF-α and IL-6 production in the plasma were increased by L-NAME treatment. In conclusion, our results showed that active substances of Aronia melanocarpa may have a positive effect on blood pressure, NOS activity, and proinflammatory processes in L-NAME-induced hypertension. PMID:29333212

Selected Topics in Overset Technology Development and Applications At NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Chan, William M.; Kwak, Dochan (Technical Monitor)

2002-01-01

This paper presents a general overview of overset technology development and applications at NASA Ames Research Center. The topics include: 1) Overview of overset activities at NASA Ames; 2) Recent developments in Chimera Grid Tools; 3) A general framework for multiple component dynamics; 4) A general script module for automating liquid rocket sub-systems simulations; and 5) Critical future work.

ACD16-0001-043

NASA Image and Video Library

2016-01-06

Senior executives from the Renault-Nissan Alliance, including Carlos Ghosn, chairman and CEO of Nissan, and Jose Munoz, chairman of Nissan North America, visited Ames for meetings and a showcase of the technical partnership between NASA and Nissan North America. Shown here on left is Carlos Ghosn, CEO, Nissan on right Eugene Tu, Ames Center Director in front to the NASA sign at the VMS Facility at Ames Research Center ,CA.

Flight Simulation.

DTIC Science & Technology

1986-09-01

TECHNICAL EVALUATION REPORT OF THE SYMPOSIUM ON "FLIGHT SIMULATION" A. M. Cook. NASA -Ames Research Center 1. INTRODUCIL𔃻N This report evaluates the 67th...John C. Ousterberry* NASA Ames Research Center Moffett Field, California 94035, U.S.A. SUMMARY Early AGARD papers on manned flight simulation...and developffent simulators. VISUAL AND MOTION CUEING IN HELICOPTER SIMULATION Nichard S. Bray NASA Ames Research Center Moffett Field, California

AME - Asteroseismology Made Easy. Estimating stellar properties by using scaled models

NASA Astrophysics Data System (ADS)

Lundkvist, Mia; Kjeldsen, Hans; Silva Aguirre, Victor

2014-06-01

Context. Stellar properties and, in particular stellar radii of exoplanet host stars, are essential for measuring the properties of exoplanets, therefore it is becoming increasingly important to be able to supply reliable stellar radii fast. Grid-modelling is an obvious choice for this, but that only offers a low degree of transparency to non-specialists. Aims: Here we present a new, easy, fast, and transparent method of obtaining stellar properties for stars exhibiting solar-like oscillations. The method, called Asteroseismology Made Easy (AME), can determine stellar masses, mean densities, radii, and surface gravities, as well as estimate ages. We present AME as a visual and powerful tool that could be useful, in particular, in light of the large number of exoplanets being found. Methods: AME consists of a set of figures from which the stellar parameters can be deduced. These figures are made from a grid of stellar evolutionary models that cover masses ranging from 0.7 M⊙ to 1.6 M⊙ in steps of 0.1 M⊙ and metallicities in the interval -0.3 dex ≤ [Fe/H] ≤ +0.3 dex in increments of 0.1 dex. The stellar evolutionary models are computed using the Modules for Experiments in Stellar Astrophysics (MESA) code with simple input physics. Results: We have compared the results from AME with results for three groups of stars: stars with radii determined from interferometry (and measured parallaxes), stars with radii determined from measurements of their parallaxes (and calculated angular diameters), and stars with results based on modelling their individual oscillation frequencies. We find that a comparison of the radii from interferometry to those from AME yields a weighted mean of the fractional differences of just 2%. This is also the level of deviation that we find when we compare the parallax-based radii to the radii determined from AME. Conclusions: The comparison between independently determined stellar parameters and those found using AME show that our method can provide reliable stellar masses, radii, and ages, with median uncertainties in the order of 4%, 2%, and 25%, respectively. http://sac.au.dk/scientific-data/ame

Building Climate Resilience at NASA Ames Research Center

NASA Astrophysics Data System (ADS)

Iraci, L. T.; Mueller, C.; Podolske, J. R.; Milesi, C.

2016-12-01

NASA Ames Research Center, located at the southern end of the San Francisco Bay (SFB) estuary, has identified three primary vulnerabilities to changes in climate. The Ames Climate Adaptation Science Investigator (CASI) workgroup has studied each of these challenges to operations and the potential exposure of infrastructure and employees to an increased frequency of hazards. Sea level rise inundation scenarios for the SFB Area generally refer to projected scenarios in mean sea level rather than changes in extreme tides that could occur during future storm conditions. In the summer of 2014, high resolution 3-D mapping of the low-lying portion of Ames was performed. Those data are integrated with improved sea level inundation scenarios to identify the buildings, basements and drainage systems potentially affected. We will also identify the impacts of sea level and storm surge effects on transportation to and from the Center. This information will help Center management develop future master plans. Climate change will also lead to changes in temperature, storm frequency and intensity. These changes have potential impacts on localized floods and ecosystems, as well as on electricity and water availability. Over the coming decades, these changes will be imposed on top of ongoing land use and land cover changes, especially those deriving from continued urbanization and increase in impervious surface areas. These coupled changes have the potential to create a series of cascading impacts on ecosystems, including changes in primary productivity and disturbance of hydrological properties and increased flood risk. The majority of the electricity used at Ames is supplied by hydroelectric dams, which will be influenced by reductions in precipitation or changes in the timing or phase of precipitation which reduces snow pack. Coupled with increased demand for summertime air conditioning and other cooling needs, NASA Ames is at risk for electricity shortfalls. To assess the anticipated energy usage as climate changes, the Ames CASI team is collecting historical energy usage data from Ames facilities, historical weather data, and projected future weather parameters from the CASI Climate subgroup. This data will be incorporated into the RETScreen model to predict how energy usage at Ames will change over the coming century.

Infant Transport Monitoring

NASA Technical Reports Server (NTRS)

1978-01-01

The photo sequence illustrates the movement of an ill infant to a special care hospital by means of a new Pediatric Monitoring and Transport System, in which NASA technology and technical assistance are being applied to an urgent medical problem. Development of the system is a collaborative effort involving several organizations, principally, NASA Ames Research Center and Children's Hospital Medical Center, Oakland, California. Key to the system's efficacy is a custom-designed ambulance-to-hospital and hospital-to-hospital communications network, including two-way voice capability and space-derived biotelemetry; it allows a specialist at the destination hospital to monitor continuously the vital signs of the patient during transit.

Optimizing Dynamical Network Structure for Pinning Control

NASA Astrophysics Data System (ADS)

Orouskhani, Yasin; Jalili, Mahdi; Yu, Xinghuo

2016-04-01

Controlling dynamics of a network from any initial state to a final desired state has many applications in different disciplines from engineering to biology and social sciences. In this work, we optimize the network structure for pinning control. The problem is formulated as four optimization tasks: i) optimizing the locations of driver nodes, ii) optimizing the feedback gains, iii) optimizing simultaneously the locations of driver nodes and feedback gains, and iv) optimizing the connection weights. A newly developed population-based optimization technique (cat swarm optimization) is used as the optimization method. In order to verify the methods, we use both real-world networks, and model scale-free and small-world networks. Extensive simulation results show that the optimal placement of driver nodes significantly outperforms heuristic methods including placing drivers based on various centrality measures (degree, betweenness, closeness and clustering coefficient). The pinning controllability is further improved by optimizing the feedback gains. We also show that one can significantly improve the controllability by optimizing the connection weights.

NASA Ames Participates in Two Major Bay Area Events (Reporter Package)NASA Ames Research Center participated in two important outreach events: Maker Faire and a gathering of hardware and software industry professionals called the Solid Conference. The conference was an opportunity for the Intelligent Robotics Group from NASA Ames to publicly unveil their latest version of the free flying robot used on the International Space Station. NASA also participated at the Bay Area Maker Faire, a gathering of more than 120,000 innovators, enthusiasts, crafters, hobbyists and tinkerers to share what they have invented and made.

NASA Image and Video Library

2014-05-28

NASA Ames Research Center participated in two important outreach events: Maker Faire and a gathering of hardware and software industry professionals called the Solid Conference. The conference was an opportunity for the Intelligent Robotics Group from NASA Ames to publicly unveil their latest version of the free flying robot used on the International Space Station. NASA also participated at the Bay Area Maker Faire, a gathering of more than 120,000 innovators, enthusiasts, crafters, hobbyists and tinkerers to share what they have invented and made.

NASA Ames DEVELOP Interns: Helping the Western United States Manage Natural Resources One Project at a Time

NASA Technical Reports Server (NTRS)

Justice, Erin; Newcomer, Michelle

2010-01-01

The western half of the United States is made up of a number of diverse ecosystems ranging from arid desert to coastal wetlands and rugged forests. Every summer for the past 7 years students ranging from high school to graduate level gather at NASA Ames Research Center (ARC) as part of the DEVELOP Internship Program. Under the guidance of Jay Skiles [Ames Research Center (ARC) - Ames DEVELOP Manager] and Cindy Schmidt [ARC/San Jose State University Ames DEVELOP Coordinator] they work as a team on projects exploring topics including: invasive species, carbon flux, wetland restoration, air quality monitoring, storm visualizations, and forest fires. The study areas for these projects have been in Washington, Utah, Oregon, Nevada, Hawaii, Alaska and California. Interns combine data from NASA and partner satellites with models and in situ measurements to complete prototype projects demonstrating how NASA data and resources can help communities tackle their Earth Science related problems.

NASA Ames Celebrates Curiosity Rover's Landing on Mars (Reporter Package)

NASA Image and Video Library

2012-08-08

Nearly 7,000 people came to NASA Ames Research Center, Moffett Field, Calif., to watch the Mars Science Laboratory rover Curiosity land on Mars. A full day's worth of activities and discussions with local Mars experts informed attendees about the contributions NASA Ames made to the mission. The highlight of the event was the live NASA TV broadcast of MSL's entry, descent and landing on the Martian surface.

ARC-2008-ACD08-0186-005

NASA Image and Video Library

2008-07-30

NASA Ames Robotics Academy Interns at the Lunar Science Institute (LSI) building 17 Interns: David Black, Michael Zwach, Guy Chriqui, Mark Mordarski Jr., Katy Levinson, Daniela Buchman, Scott Strutner, Patrick Crownover, Neil Bhateja, Michael Buchman, John Mueller, Michelle Grau, Ben Silver, Jacques Dolan, Alex Golec Windell Jones, Colin Wilson, Joe DeBlasio, Nick Hayes, Jordan Olive, William Shaw, Ames Education Dept., Mark Leon, Ames Robotics, Josh Weiner, jack Biesiadecki, Andrew Pilloud

Aviation Medical Examiner 2012 Feedback Survey: Content Analysis of Recommendations

DTIC Science & Technology

2013-06-01

not for the purpose of comparison but due to different operational conditions. Results provide a programmatic view of AME-recommended improvements...type of AME, not for purposes of comparison, but due to different operational conditions. Two AME groups were created--a domestic group and a combined...were distinct differences between the groups (Table 22), which likely reflects differences in levels of experience with the various systems /tools

ARC-2010-ACD10-0066-001

NASA Image and Video Library

2010-04-09

Netherlands Memorandum of Record (MOR) agreement signing and visit to the NASA Ames Research Center, Mofffett Field, California. At the table are left to right, Dr. Scott Sanford, NASA Ames, Dr Alexander Tielens, former NASA Civil Servant and former SOFIA Project Scientist, Dr Andrew Mattioda, NASA Ames, Dr. Louis B.J.Vertegaal, Director of Physical Sciences, Chemistry, and Advanced Chemical Technologies for Sustainability, of the Netherlands Organisation for Scientific Research (NWO)

Some innovations and accomplishments of Ames Research Center since its inception

NASA Technical Reports Server (NTRS)

1987-01-01

The innovations and accomplishments of Ames Research Center from 1940 through 1966 are summarized and illustrated. It should be noted that a number of accomplishments were begun at the NASA Dryden Flight Research Facility before that facility became part of the Ames Research Center. Such accomplishments include the first supersonic flight, the first hypersonic flight, the lunar landing research vehicle, and the first digital fly-by-wire aircraft.

IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity.

PubMed

Papaconstantinou, John; Hsieh, Ching-Chyuan

2015-11-03

Insulin/IGF-1 signaling involves phosphorylation/dephosphorylation of serine/threonine or tyrosine residues of the insulin receptor substrate (IRS) proteins and is associated with hormonal control of longevity determination of certain long-lived mice. The stimulation of serine phosphorylations by IGF-1 suggests there is insulin/IGF-1 crosstalk that involves the phosphorylation of the same serine residues. By this mechanism, insulin and IGF-1 mediated phosphorylation of specific IRS-1 serines could play a role in longevity determination.We used fibroblasts from WT and Ames dwarf mice to examine whether: (a) IGF-1 stimulates phosphorylation of IRS-1 serines targeted by insulin; (b) the levels of serine phosphorylation differ in WT vs. Ames fibroblasts; and (c) aging affects the levels of these serine phosphorylations which are altered in the Ames dwarf mutant. We have shown that IRS-1 is a substrate for IGF-1 induced phosphorylation of Ser307, Ser612, Ser636/639, and Ser1101; that the levels of phosphorylation of these serines are significantly lower in Ames vs. WT cells; that IGF-1 mediated phosphorylation of these serines increases with age in WT cells. We propose that insulin/IGF-1 cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf longevity phenotype.

RIACS

NASA Technical Reports Server (NTRS)

Moore, Robert C.

1998-01-01

The Research Institute for Advanced Computer Science (RIACS) was established by the Universities Space Research Association (USRA) at the NASA Ames Research Center (ARC) on June 6, 1983. RIACS is privately operated by USRA, a consortium of universities that serves as a bridge between NASA and the academic community. Under a five-year co-operative agreement with NASA, research at RIACS is focused on areas that are strategically enabling to the Ames Research Center's role as NASA's Center of Excellence for Information Technology. The primary mission of RIACS is charted to carry out research and development in computer science. This work is devoted in the main to tasks that are strategically enabling with respect to NASA's bold mission in space exploration and aeronautics. There are three foci for this work: (1) Automated Reasoning. (2) Human-Centered Computing. and (3) High Performance Computing and Networking. RIACS has the additional goal of broadening the base of researcher in these areas of importance to the nation's space and aeronautics enterprises. Through its visiting scientist program, RIACS facilitates the participation of university-based researchers, including both faculty and students, in the research activities of NASA and RIACS. RIACS researchers work in close collaboration with NASA computer scientists on projects such as the Remote Agent Experiment on Deep Space One mission, and Super-Resolution Surface Modeling.

Anatomy and physiology of neurons with processes in the accessory medulla of the cockroach Leucophaea maderae.

PubMed

Loesel, R; Homberg, U

2001-10-15

The accessory medulla (AMe), a small neuropil in the insect optic lobe, has been proposed to serve a circadian pacemaker function analogous to the role of the suprachiasmatic nucleus in mammals. Building upon considerable knowledge of the circadian system of the cockroach Leucophaea maderae, we investigated the properties of AMe neurons in this insect with intracellular recordings combined with dye injections. Responses of neurons with processes in the AMe to visual stimuli, including stationary white light, moving objects, and polarized light were compared with the responses of adjacent medulla tangential neurons. Neurons with processes in the AMe and additional ramifications in the medulla strongly responded to stationary light stimuli and might, therefore, be part of photic entrainment pathways to the clock. Accessory medulla neurons lacking significant processes in the medulla but with projections to the midbrain or to the contralateral optic lobe, in contrast, responded weakly or not at all to light and, thus, seem to be part of the clock's output pathway. Two types of commissural neurons with tangential arborizations in both medullae were sensitive to polarized light, suggesting a role of these neurons in celestial navigation. Sidebranches in the AMae of one of the two cell types are discussed with respect to a possible involvement of the AMe in polarization vision. Finally, neurons responding to movement stimuli did not arborize in the AMe. The results show that the AMe receives photic input and support a role of this neuropil in circadian timekeeping functions. Copyright 2001 Wiley-Liss, Inc.

E-Unification of Koreas: Dreams, Plans and Realities

DTIC Science & Technology

2005-08-01

interesting political and social ramifications, which must be brought into the picture. North and South Korea present very contrasting pictures in...Seoul, ROK, May 22, 2002 Timothy Beal 384 Figure 19.4. Dinga the Lazy Cat Source: <http://english.joins.com/nk/col/ Media /Img/dingae.jpg...Calculation, OA; • Medical Electronic Appliances &Program Section - Diagnosis & Treatment Appliances; • Network & Communication / Security, B2B , B2C

Association between the Presence of Aminoglycoside-Modifying Enzymes and In Vitro Activity of Gentamicin, Tobramycin, Amikacin, and Plazomicin against Klebsiella pneumoniae Carbapenemase- and Extended-Spectrum-β-Lactamase-Producing Enterobacter Species.

PubMed

Haidar, Ghady; Alkroud, Ammar; Cheng, Shaoji; Churilla, Travis M; Churilla, Bryce M; Shields, Ryan K; Doi, Yohei; Clancy, Cornelius J; Nguyen, M Hong

2016-09-01

We compared the in vitro activities of gentamicin (GEN), tobramycin (TOB), amikacin (AMK), and plazomicin (PLZ) against 13 Enterobacter isolates possessing both Klebsiella pneumoniae carbapenemase and extended-spectrum β-lactamase (KPC+/ESBL+) with activity against 8 KPC+/ESBL-, 6 KPC-/ESBL+, and 38 KPC-/ESBL- isolates. The rates of resistance to GEN and TOB were higher for KPC+/ESBL+ (100% for both) than for KPC+/ESBL- (25% and 38%, respectively), KPC-/ESBL+ (50% and 17%, respectively), and KPC-/ESBL- (0% and 3%, respectively) isolates. KPC+/ESBL+ isolates were more likely than others to possess an aminoglycoside-modifying enzyme (AME) (100% versus 38%, 67%, and 5%; P = 0.007, 0.06, and <0.0001, respectively) or multiple AMEs (100% versus 13%, 33%, and 0%, respectively; P < 0.01 for all). KPC+/ESBL+ isolates also had a greater number of AMEs (mean of 4.6 versus 1.5, 0.9, and 0.05, respectively; P < 0.01 for all). GEN and TOB MICs were higher against isolates with >1 AME than with ≤1 AME. The presence of at least 2/3 of KPC, SHV, and TEM predicted the presence of AMEs. PLZ MICs against all isolates were ≤4 μg/ml, regardless of KPC/ESBL pattern or the presence of AMEs. In conclusion, GEN and TOB are limited as treatment options against KPC+ and ESBL+ Enterobacter PLZ may represent a valuable addition to the antimicrobial armamentarium. A full understanding of AMEs and other aminoglycoside resistance mechanisms will allow clinicians to incorporate PLZ rationally into treatment regimens. The development of molecular assays that accurately and rapidly predict antimicrobial responses among KPC- and ESBL-producing Enterobacter spp. should be a top research priority. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Association between the Presence of Aminoglycoside-Modifying Enzymes and In Vitro Activity of Gentamicin, Tobramycin, Amikacin, and Plazomicin against Klebsiella pneumoniae Carbapenemase- and Extended-Spectrum-β-Lactamase-Producing Enterobacter Species

PubMed Central

Haidar, Ghady; Alkroud, Ammar; Cheng, Shaoji; Churilla, Travis M.; Churilla, Bryce M.; Shields, Ryan K.; Doi, Yohei; Clancy, Cornelius J.

2016-01-01

We compared the in vitro activities of gentamicin (GEN), tobramycin (TOB), amikacin (AMK), and plazomicin (PLZ) against 13 Enterobacter isolates possessing both Klebsiella pneumoniae carbapenemase and extended-spectrum β-lactamase (KPC+/ESBL+) with activity against 8 KPC+/ESBL−, 6 KPC−/ESBL+, and 38 KPC−/ESBL− isolates. The rates of resistance to GEN and TOB were higher for KPC+/ESBL+ (100% for both) than for KPC+/ESBL− (25% and 38%, respectively), KPC−/ESBL+ (50% and 17%, respectively), and KPC−/ESBL− (0% and 3%, respectively) isolates. KPC+/ESBL+ isolates were more likely than others to possess an aminoglycoside-modifying enzyme (AME) (100% versus 38%, 67%, and 5%; P = 0.007, 0.06, and <0.0001, respectively) or multiple AMEs (100% versus 13%, 33%, and 0%, respectively; P < 0.01 for all). KPC+/ESBL+ isolates also had a greater number of AMEs (mean of 4.6 versus 1.5, 0.9, and 0.05, respectively; P < 0.01 for all). GEN and TOB MICs were higher against isolates with >1 AME than with ≤1 AME. The presence of at least 2/3 of KPC, SHV, and TEM predicted the presence of AMEs. PLZ MICs against all isolates were ≤4 μg/ml, regardless of KPC/ESBL pattern or the presence of AMEs. In conclusion, GEN and TOB are limited as treatment options against KPC+ and ESBL+ Enterobacter. PLZ may represent a valuable addition to the antimicrobial armamentarium. A full understanding of AMEs and other aminoglycoside resistance mechanisms will allow clinicians to incorporate PLZ rationally into treatment regimens. The development of molecular assays that accurately and rapidly predict antimicrobial responses among KPC- and ESBL-producing Enterobacter spp. should be a top research priority. PMID:27297487

Real time measurement of transient event emissions of air toxics by tomographic remote sensing in tandem with mobile monitoring

NASA Astrophysics Data System (ADS)

Olaguer, Eduardo P.; Stutz, Jochen; Erickson, Matthew H.; Hurlock, Stephen C.; Cheung, Ross; Tsai, Catalina; Colosimo, Santo F.; Festa, James; Wijesinghe, Asanga; Neish, Bradley S.

2017-02-01

During the Benzene and other Toxics Exposure (BEE-TEX) study, a remote sensing network based on long path Differential Optical Absorption Spectroscopy (DOAS) was set up in the Manchester neighborhood beside the Ship Channel of Houston, Texas in order to perform Computer Aided Tomography (CAT) scans of hazardous air pollutants. On 18-19 February 2015, the CAT scan network detected large nocturnal plumes of toluene and xylenes most likely associated with railcar loading and unloading operations at Ship Channel petrochemical facilities. The presence of such plumes during railcar operations was confirmed by a mobile laboratory equipped with a Proton Transfer Reaction-Mass Spectrometer (PTR-MS), which measured transient peaks of toluene and C2-benzenes of 50 ppb and 57 ppb respectively around 4 a.m. LST on 19 February 2015. Plume reconstruction and source attribution were performed using the 4D variational data assimilation technique and a 3D micro-scale forward and adjoint air quality model based on both tomographic and PTR-MS data. Inverse model estimates of fugitive emissions associated with railcar transfer emissions ranged from 2.0 to 8.2 kg/hr for toluene and from 2.2 to 3.5 kg/hr for xylenes in the early morning of 19 February 2015.

Research and technology

NASA Technical Reports Server (NTRS)

1986-01-01

This report describes various research and technology activities at Ames Moffett and Ames Dryden. Highlights of these accomplishments indicate the Center's varied and highly productive research efforts for 1985.

Perceptual Performance Impact of GPU-Based WARP and Anti-Aliasing for Image Generators

DTIC Science & Technology

2016-06-29

with the Air Force Research Laboratory (AFRL) and NASA AMES, constructed the Operational Based Vision Assessment (OBVA) simulator. This 15-channel, 150...ABSTRACT In 2012 the U.S. Air Force School of Aerospace Medicine, in partnership with the Air Force Research Laboratory (AFRL) and NASA AMES...with the Air Force Research Laboratory (AFRL) and NASA AMES, constructed the Operational Based Vision Assessment (OBVA) simulator to evaluate the

1993 Technical Paper Contest for Women. Gear Up 2000: Women in Motion

NASA Technical Reports Server (NTRS)

Orans, Robin (Editor); Duckett, Sophie (Editor); White, Susan (Editor)

1994-01-01

The NASA Ames Research Center Advisory Committee for Women (ACW) sponsored the second ACW Technical paper Contest for Ames women in order to increase the visibility of, and to encourage writing for publication by Ames women scientists, engineers, and technicians. The topics of the contest paper mirrored in the topics of the 1993 Society for Women Engineers (SWE) National Convention, which included technological, workplace, global, and family issues.

The viability of establishing collaborative, reconfigurable research environments for the Human Performance Research Laboratory at NASA Ames

NASA Technical Reports Server (NTRS)

Clipson, Colin

1994-01-01

This paper will review and summarize research initiatives conducted between 1987 and 1992 at NASA Ames Research Center by a research team from the University of Michigan Architecture Research Laboratory. These research initiatives, funded by a NASA grant NAG2-635, examined the viability of establishing collaborative, reconfigurable research environments for the Human Performance Research Laboratory at NASA Ames in California. Collaborative Research Environments are envisioned as a way of enhancing the work of NASA research teams, optimizing the use of shared resources, and providing superior environments for housing research activities. The Integrated Simulation Project at NASA, Ames Human Performance Research Laboratory is one of the current realizations of this initiative.

The resolving power of in vitro genotoxicity assays for cigarette smoke particulate matter.

PubMed

Scott, K; Saul, J; Crooks, I; Camacho, O M; Dillon, D; Meredith, C

2013-06-01

In vitro genotoxicity assays are often used to compare tobacco smoke particulate matter (PM) from different cigarettes. The quantitative aspect of the comparisons requires appropriate statistical methods and replication levels, to support the interpretation in terms of power and significance. This paper recommends a uniform statistical analysis for the Ames test, mouse lymphoma mammalian cell mutation assay (MLA) and the in vitro micronucleus test (IVMNT); involving a hierarchical decision process with respect to slope, fixed effect and single dose comparisons. With these methods, replication levels of 5 (Ames test TA98), 4 (Ames test TA100), 10 (Ames test TA1537), 6 (MLA) and 4 (IVMNT) resolved a 30% difference in PM genotoxicity. Copyright © 2013 Elsevier Ltd. All rights reserved.

Bacteriorhodopsin films for optical signal processing and data storage

NASA Technical Reports Server (NTRS)

Walkup, John F. (Principal Investigator); Mehrl, David J. (Principal Investigator)

1996-01-01

This report summarizes the research results obtained on NASA Ames Grant NAG 2-878 entitled 'Investigations of Bacteriorhodopsin Films for Optical Signal Processing and Data Storage.' Specifically we performed research, at Texas Tech University, on applications of Bacteriorhodopisin film to both (1) dynamic spatial filtering and (2) holographic data storage. In addition, measurements of the noise properties of an acousto-optical matrix-vestor multiplier built for NASA Ames by Photonic Systems Inc. were performed at NASA Ames' Photonics Laboratory. This research resulted in two papers presented at major optical data processing conferences and a journal paper which is to appear in APPLIED OPTICS. A new proposal for additional BR research has recently been submitted to NASA Ames Research Center.

A Small World of Neuronal Synchrony

PubMed Central

Yu, Shan; Huang, Debin; Singer, Wolf

2008-01-01

A small-world network has been suggested to be an efficient solution for achieving both modular and global processing—a property highly desirable for brain computations. Here, we investigated functional networks of cortical neurons using correlation analysis to identify functional connectivity. To reconstruct the interaction network, we applied the Ising model based on the principle of maximum entropy. This allowed us to assess the interactions by measuring pairwise correlations and to assess the strength of coupling from the degree of synchrony. Visual responses were recorded in visual cortex of anesthetized cats, simultaneously from up to 24 neurons. First, pairwise correlations captured most of the patterns in the population's activity and, therefore, provided a reliable basis for the reconstruction of the interaction networks. Second, and most importantly, the resulting networks had small-world properties; the average path lengths were as short as in simulated random networks, but the clustering coefficients were larger. Neurons differed considerably with respect to the number and strength of interactions, suggesting the existence of “hubs” in the network. Notably, there was no evidence for scale-free properties. These results suggest that cortical networks are optimized for the coexistence of local and global computations: feature detection and feature integration or binding. PMID:18400792

Creating Efficient Instrumentation Networks to Support Parametric Risk Transfer

NASA Astrophysics Data System (ADS)

Rockett, P.

2009-04-01

The development and institutionalisation of Catastrophe modelling during the 1990s opened the way for Catastrophe risk securitization transactions in which catastrophe risk held by insurers is transferred to the capital markets in the form of a bond. Cat Bonds have been one of the few areas of the capital markets in which the risk modelling has remained secure and the returns on the bonds have held up well through the 2008 Credit Crunch. There are three ways of structuring the loss triggers on bonds: ‘indemnity triggers' - reflecting the actual losses to the issuers; ‘index triggers' reflecting the losses to some index such as reported insurance industry loss and ‘parametric triggers' reflecting the parameters of the underlying catastrophe event itself. Indemnity triggers require that the investors trust that the insurer is reporting all their underlying exposures, while both indemnity and index losses may take 1-2 years to settle before all the claims are reported and resolved. Therefore parametric structures have many advantages, in particular in that the bond can be settled rapidly after an event. The challenge is to create parametric indices that closely reflect the actual losses to the insurer - ie that minimise ‘basis risk'. First generation parametric indices had high basis risk as they were crudely based on the magnitude of an earthquake occurring within some defined geographical box, or the intensity of a hurricane relative to the distance of the storm from some location. Second generation triggers involve taking measurements of ground motion or windspeed or flood depths at many locations and weighting each value so that the overall index closely mimics insurance loss. Cat bonds with second generation parametric triggers have been successfully issued for European Windstorm, UK Flood and California and Japan Earthquake. However the spread of second generation parametric structures is limited by the availability of suitable networks of instrumentation. For example, even along the US coast, National Weather Service windspeed recorders are not designed to withstand the most intense hurricane winds, and with only 30 minutes of battery life, fail to record through major storms with their ubiquitous power outages. New, privately financed, windspeed recording networks are now being installed that are hurricane resistant and have long-life batteries to ensure that windspeeds will always be recorded and can then be employed in Cat bond triggers. For the developing world, the installation and maintenance of resilient recording networks can kick-start risk transfer mechanisms even in the absence of insurance.

Demographics of dogs, cats, and rabbits attending veterinary practices in Great Britain as recorded in their electronic health records.

PubMed

Sánchez-Vizcaíno, Fernando; Noble, Peter-John M; Jones, Phil H; Menacere, Tarek; Buchan, Iain; Reynolds, Suzanna; Dawson, Susan; Gaskell, Rosalind M; Everitt, Sally; Radford, Alan D

2017-07-11

Understanding the distribution and determinants of disease in animal populations must be underpinned by knowledge of animal demographics. For companion animals, these data have been difficult to collect because of the distributed nature of the companion animal veterinary industry. Here we describe key demographic features of a large veterinary-visiting pet population in Great Britain as recorded in electronic health records, and explore the association between a range of animal's characteristics and socioeconomic factors. Electronic health records were captured by the Small Animal Veterinary Surveillance Network (SAVSNET), from 143 practices (329 sites) in Great Britain. Mixed logistic regression models were used to assess the association between socioeconomic factors and species and breed ownership, and preventative health care interventions. Dogs made up 64.8% of the veterinary-visiting population, with cats, rabbits and other species making up 30.3, 2.0 and 1.6% respectively. Compared to cats, dogs and rabbits were more likely to be purebred and younger. Neutering was more common in cats (77.0%) compared to dogs (57.1%) and rabbits (45.8%). The insurance and microchipping relative frequency was highest in dogs (27.9 and 53.1%, respectively). Dogs in the veterinary-visiting population belonging to owners living in least-deprived areas of Great Britain were more likely to be purebred, neutered, insured and microchipped. The same association was found for cats in England and for certain parameters in Wales and Scotland. The differences we observed within these populations are likely to impact on the clinical diseases observed within individual veterinary practices that care for them. Based on this descriptive study, there is an indication that the population structures of companion animals co-vary with human and environmental factors such as the predicted socioeconomic level linked to the owner's address. This 'co-demographic' information suggests that further studies of the relationship between human demographics and pet ownership are warranted.

Renal pelvic and ureteral ultrasonographic characteristics of cats with chronic kidney disease in comparison with normal cats, and cats with pyelonephritis or ureteral obstruction.

PubMed

Quimby, Jessica M; Dowers, Kristy; Herndon, Andrea K; Randall, Elissa K

2017-08-01

Objectives The objective was to describe ultrasonographic characteristics of cats with stable chronic kidney disease (CKD) and determine if these were significantly different from cats with pyelonephritis (Pyelo) and ureteral obstruction (UO), to aid in clinical assessment during uremic crisis. Methods Sixty-six cats with stable CKD were prospectively enrolled, as well as normal control cats (n = 10), cats with a clinical diagnosis of Pyelo (n = 13) and cats with UO confirmed by surgical resolution (n = 11). Renal ultrasound was performed and routine still images and cine loops were obtained. Analysis included degree of pelvic dilation, and presence and degree of ureteral dilation. Measurements were compared between groups using non-parametric one-way ANOVA with Dunn's post-hoc analysis. Results In total, 66.6% of CKD cats had measurable renal pelvic dilation compared with 30.0% of normal cats, 84.6% of Pyelo cats and 100% of UO cats. There was no statistically significant difference in renal pelvic widths between CKD cats and normal cats, or CKD cats and Pyelo cats. On almost all measurement categories, UO cats had significantly greater renal pelvic widths compared with CKD cats and normal cats ( P <0.05) but not Pyelo cats. Six percent of stable CKD cats had measurable proximal ureteral dilation on one or both sides vs 46.2% of Pyelo cats and 81.8% of UO cats. There was no statistically significant difference in proximal ureteral width between normal and CKD cats, or between Pyelo and UO cats. There was a statistically significant difference in proximal ureteral width between CKD and Pyelo cats, CKD and UO cats, normal and UO cats, and normal and Pyelo cats. Conclusions and relevance No significant difference in renal pelvic widths between CKD cats and Pyelo cats was seen. These data suggest CKD cats should have a baseline ultrasonography performed so that abnormalities documented during a uremic crisis can be better interpreted.

Ames Research Center Publications-1976

NASA Technical Reports Server (NTRS)

Sherwood, B.

1978-01-01

Bibliography of the publications of Ames Research Center authors and contractors, which appeared in formal NASA publications, journal articles, books, chapters of books, patents, and contractor reports. Covers 1976.

Research and technology

NASA Technical Reports Server (NTRS)

1988-01-01

This report describes various research and technology activities at Ames Moffett and Ames Dryden Research Centers. Highlights of these accomplishments indicate the Centers' varied and highly productive research efforts for 1987.

Corrective Action Plan in response to the March 1992 Tiger Team Assessment of the Ames Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-11-20

On March 5, 1992, a Department of Energy (DOE) Tiger Team completed an assessment of the Ames Laboratory, located in Ames, Iowa. The purpose of the assessment was to provide the Secretary of Energy with a report on the status and performance of Environment, Safety and Health (ES H) programs at Ames Laboratory. Detailed findings of the assessment are presented in the report, DOE/EH-0237, Tiger Team Assessment of the Ames Laboratory. This document, the Ames Laboratory Corrective Action Plan (ALCAP), presents corrective actions to overcome deficiencies cited in the Tiger Team Assessment. The Tiger Team identified 53 Environmental findings, frommore » which the Team derived four key findings. In the Safety and Health (S H) area, 126 concerns were identified, eight of which were designated Category 11 (there were no Category I concerns). Seven key concerns were derived from the 126 concerns. The Management Subteam developed 19 findings which have been summarized in four key findings. The eight S H Category 11 concerns identified in the Tiger Team Assessment were given prompt management attention. Actions to address these deficiencies have been described in individual corrective action plans, which were submitted to DOE Headquarters on March 20, 1992. The ALCAP includes actions described in this early response, as well as a long term strategy and framework for correcting all remaining deficiencies. Accordingly, the ALCAP presents the organizational structure, management systems, and specific responses that are being developed to implement corrective actions and to resolve root causes identified in the Tiger Team Assessment. The Chicago Field Office (CH), IowaState University (ISU), the Institute for Physical Research and Technology (IPRT), and Ames Laboratory prepared the ALCAP with input from the DOE Headquarters, Office of Energy Research (ER).« less

Corrective Action Plan in response to the March 1992 Tiger Team Assessment of the Ames Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-11-20

On March 5, 1992, a Department of Energy (DOE) Tiger Team completed an assessment of the Ames Laboratory, located in Ames, Iowa. The purpose of the assessment was to provide the Secretary of Energy with a report on the status and performance of Environment, Safety and Health (ES&H) programs at Ames Laboratory. Detailed findings of the assessment are presented in the report, DOE/EH-0237, Tiger Team Assessment of the Ames Laboratory. This document, the Ames Laboratory Corrective Action Plan (ALCAP), presents corrective actions to overcome deficiencies cited in the Tiger Team Assessment. The Tiger Team identified 53 Environmental findings, from whichmore » the Team derived four key findings. In the Safety and Health (S&H) area, 126 concerns were identified, eight of which were designated Category 11 (there were no Category I concerns). Seven key concerns were derived from the 126 concerns. The Management Subteam developed 19 findings which have been summarized in four key findings. The eight S&H Category 11 concerns identified in the Tiger Team Assessment were given prompt management attention. Actions to address these deficiencies have been described in individual corrective action plans, which were submitted to DOE Headquarters on March 20, 1992. The ALCAP includes actions described in this early response, as well as a long term strategy and framework for correcting all remaining deficiencies. Accordingly, the ALCAP presents the organizational structure, management systems, and specific responses that are being developed to implement corrective actions and to resolve root causes identified in the Tiger Team Assessment. The Chicago Field Office (CH), IowaState University (ISU), the Institute for Physical Research and Technology (IPRT), and Ames Laboratory prepared the ALCAP with input from the DOE Headquarters, Office of Energy Research (ER).« less

Intoxication-Related Alcohol Mixed with Energy Drink Expectancies Scale: Initial Development and Validation.

PubMed

Miller, Kathleen E; Dermen, Kurt H; Lucke, Joseph F

2017-06-01

Young adult use of alcohol mixed with energy drinks (AmEDs) has been linked with elevated risks of a constellation of problem behaviors. These risks may be conditioned by expectancies regarding the effects of caffeine in conjunction with alcohol consumption. The aim of this study was to describe the construction and psychometric evaluation of the Intoxication-Related AmED Expectancies Scale (AmED_EXPI), 15 self-report items measuring beliefs about how the experience of AmED intoxication differs from the experience of noncaffeinated alcohol (NCA) intoxication. Scale development and testing were conducted using data from a U.S. national sample of 3,105 adolescents and emerging adults aged 13 to 25. Exploratory and confirmatory factor analyses were conducted to evaluate the factor structure and establish factor invariance across gender, age, and prior experience with AmED use. Cross-sectional and longitudinal analyses examining correlates of AmED use were used to assess construct and predictive validity. In confirmatory factor analyses, fit indices for the hypothesized 4-factor structure (i.e., Intoxication Management [IM], Alertness [AL], Sociability [SO], and Jitters [JT]) revealed a moderately good fit to the data. Together, these factors accounted for 75.3% of total variance. The factor structure was stable across male/female, teen/young adult, and AmED experience/no experience subgroups. The resultant unit-weighted subscales showed strong internal consistency and satisfactory convergent validity. Baseline scores on the IM, SO, and JT subscales predicted changes in AmED use over a subsequent 3-month period. The AmED_EXPI appears to be a reliable and valid tool for measuring expectancies about the effects of caffeine during alcohol intoxication. Copyright © 2017 by the Research Society on Alcoholism.

VizieR Online Data Catalog: Optically Bright extragalactic Radio Sources II (Petrov, 2013)

NASA Astrophysics Data System (ADS)

Petrov, L.

2014-06-01

The first VLBI (Very Long Baseline Interferometry) observing campaign in 2007 resulted in the detection of 398 targets with the European VLBI Network (EVN; Bourda et al., 2010, cat. J/A+A/520/A113). During the second observing campaign, a subset of 105 sources detected in the previous campaign was observed (Bourda et al., 2011, cat. J/A+A/526/A102). Their positions were derived by Petrov (2011, cat. J/AJ/142/105) and formed the OBRS-1 (Optically Bright extragalactic Radio Sources) catalog. The remaining sources were observed in the third campaign, called OBRS-2. During the OBRS-2 campaign, there were three observing sessions with 10 VLBA (Very Long Baseline Array) stations and 5-6 EVN stations from this list: EFLSBERG, MEDICINA, ONSALA60, YEBES40M, DSS63, HARTRAO, and NOTO. Observations were made on 2010 Mar 23 (session ID gc034a), on 2011 Nov 8 (gc034bcd), and on 2011 Mar 15 (gc034ef). The OBRS-2 catalog presents precise positions of the 295 extragalactic radio sources as well as median correlated flux densities at 8.4 and 2.2GHz at baseline lengths shorter than 900km and at baseline lengths longer than 5000km. (1 data file).

Inhalation Anthrax (Ames aerosol) in Naive and Vaccinated New Zealand Rabbits: Characterizing the Spread of Bacteria from Lung Deposition to Bacteremia

DTIC Science & Technology

2012-06-28

York City anthrax investigation working group. (2003). Isolated case of bioterrorism-related inhalational anthrax, New York City , 2001. Emerg. Infect...ORIGINAL RESEARCH ARTICLE published: 28 June 2012 doi: 10.3389/fcimb.2012.00087 Inhalational anthrax(Ames aerosol) in naïve and vaccinated New ...Inhalation Antrax (Ames aerosol) In Naive and Vaccinated New Zealand Rabbits: Characterizing The Spread Of Bacteria From Lung Deposition To Bacteremia

Can energy drinks increase the desire for more alcohol?

PubMed

Marczinski, Cecile A

2015-01-01

Energy drinks, the fastest growing segment in the beverage market, have become popular mixers with alcohol. The emerging research examining the use of alcohol mixed with energy drinks (AmEDs) indicates that the combination of caffeine-containing energy drinks with alcohol may be riskier than the use of alcohol alone. The public health concerns arising from AmED use are documented in different research domains. Epidemiologic studies reveal that the consumption of AmEDs is frequent among young and underage drinkers, demographic groups that are more likely to experience the harms and hazards associated with alcohol use. In addition, for all consumers, elevated rates of binge drinking and risk of alcohol dependence have been associated with AmED use when compared to alcohol alone. Results from laboratory studies help explain why AmED use is associated with excessive intake of alcohol. When an energy drink (or caffeine) is combined with alcohol, the desire (or urge) to drink more alcohol is more pronounced in both humans and animals than with the same dose of alcohol alone. The experience of drinking alcohol appears to be more rewarding when combined with energy drinks. Given that caffeine in other foods and beverages increases preference for those products, further research on AmEDs may elucidate the underlying mechanisms that contribute to alcohol dependence. © 2015 American Society for Nutrition.

Constitutive expression of catABC genes in the aniline-assimilating bacterium Rhodococcus species AN-22: production, purification, characterization and gene analysis of CatA, CatB and CatC

PubMed Central

Matsumura, Eitaro; Sakai, Masashi; Hayashi, Katsuaki; Murakami, Shuichiro; Takenaka, Shinji; Aoki, Kenji

2005-01-01

The aniline-assimilating bacterium Rhodococcus sp. AN-22 was found to constitutively synthesize CatB (cis,cis-muconate cycloisomerase) and CatC (muconolactone isomerase) in its cells growing on non-aromatic substrates, in addition to the previously reported CatA (catechol 1,2-dioxygenase). The bacterium maintained the specific activity of the three enzymes at an almost equal level during cultivation on succinate. CatB and CatC were purified to homogeneity and characterized. CatB was a monomer with a molecular mass of 44 kDa. The enzyme was activated by Mn2+, Co2+ and Mg2+. Native CatC was a homo-octamer with a molecular mass of 100 kDa. The enzyme was stable between pH 7.0 and 10.5 and was resistant to heating up to 90 °C. Genes coding for CatA, CatB and CatC were cloned and named catA, catB and catC respectively. The catABC genes were transcribed as one operon. The deduced amino acid sequences of CatA, CatB and CatC showed high identities with those from other Gram-positive micro-organisms. A regulator gene such as catR encoding a regulatory protein was not observed around the cat gene cluster of Rhodococcus sp. AN-22, but a possible relic of catR was found in the upstream region of catA. Reverse transcriptase-PCR and primer extension analyses showed that the transcriptional start site of the cat gene cluster was located 891 bp upstream of the catA initiation codon in the AN-22 strain growing on both aniline and succinate. Based on these data, we concluded that the bacterium constitutively transcribed the catABC genes and translated its mRNA into CatA, CatB and CatC. PMID:16156722

Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects.

PubMed

Payne, Christopher D; Deeg, Mark A; Chan, Melanie; Tan, Lai Hock; LaBell, Elizabeth Smith; Shen, Tong; DeBrota, David J

2014-12-01

The aim of this study was to assess the safety and tolerability, pharmacokinetics and pharmacodynamics of LY3000328 when administered as single escalating doses to healthy volunteers. This was a phase 1, placebo-controlled, dose escalation study with LY3000328 in 21 healthy male volunteers. Subjects were administered escalating LY3000328 doses up to 300 mg with food in this single dose study. Blood samples were collected at set times post-dose for the assessment of LY3000328 pharmacokinetics and the measurement of cathepsin S (CatS) activity, CatS mass and calculated CatS specific activity. All doses of LY3000328 were well tolerated, with linear pharmacokinetics up to the 300 mg dose. The pharmacodynamic activity of LY3000328 was measured ex vivo showing a biphasic response to LY3000328, where CatS activity declines, then returns to baseline, and then increases to a level above baseline. CatS mass was also assessed post-dose which increased in a dose-dependent manner, and continued to increase after LY3000328 had been cleared from the body. CatS specific activity was additionally calculated to normalize CatS activity for changes in CatS mass. This demonstrated the increase in CatS activity was attributable to the increase in CatS mass detected in plasma. A specific inhibitor of CatS which is cleared quickly from plasma may produce a transient decrease in plasma CatS activity which is followed by a more prolonged increase in plasma CatS mass which may have implications for the future clinical development of inhibitors of CatS. © 2014 The British Pharmacological Society.

Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects

PubMed Central

Payne, Christopher D; Deeg, Mark A; Chan, Melanie; Tan, Lai Hock; LaBell, Elizabeth Smith; Shen, Tong; DeBrota, David J

2014-01-01

Aim The aim of this study was to assess the safety and tolerability, pharmacokinetics and pharmacodynamics of LY3000328 when administered as single escalating doses to healthy volunteers. Methods This was a phase 1, placebo-controlled, dose escalation study with LY3000328 in 21 healthy male volunteers. Subjects were administered escalating LY3000328 doses up to 300 mg with food in this single dose study. Blood samples were collected at set times post-dose for the assessment of LY3000328 pharmacokinetics and the measurement of cathepsin S (CatS) activity, CatS mass and calculated CatS specific activity. Results All doses of LY3000328 were well tolerated, with linear pharmacokinetics up to the 300 mg dose. The pharmacodynamic activity of LY3000328 was measured ex vivo showing a biphasic response to LY3000328, where CatS activity declines, then returns to baseline, and then increases to a level above baseline. CatS mass was also assessed post-dose which increased in a dose-dependent manner, and continued to increase after LY3000328 had been cleared from the body. CatS specific activity was additionally calculated to normalize CatS activity for changes in CatS mass. This demonstrated the increase in CatS activity was attributable to the increase in CatS mass detected in plasma. Conclusion A specific inhibitor of CatS which is cleared quickly from plasma may produce a transient decrease in plasma CatS activity which is followed by a more prolonged increase in plasma CatS mass which may have implications for the future clinical development of inhibitors of CatS. PMID:25039273

N-232 Sustainability Base Construction

NASA Image and Video Library

2011-11-10

Construction of the new NASA Ames Green Building dubbed Sustainability Base located on the Ames Research Center campus at Moffett Field, CA. Bloom Energy, Inc. powers the building. Bloom Energy equipment

The AME2016 atomic mass evaluation (II). Tables, graphs and references

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Meng; Audi, G.; Kondev, F. G.

This paper is the second part of the new evaluation of atomic masses, Ame2016. Using least-squares adjustments to all evaluated and accepted experimental data, described in Part I, we derive tables with numerical values and graphs to replace those given in Ame2012. The first table lists the recommended atomic mass values and their uncertainties. It is followed by a table of the influences of data on primary nuclides, a table of various reaction and decay energies, and finally, a series of graphs of separation and decay energies. The last section of this paper lists all references of the input datamore » used in the Ame2016 and the Nubase2016 evaluations (first paper in this issue). Amdc: http://amdc.impcas.ac.cn/« less

Neural Networks for Flight Control

NASA Technical Reports Server (NTRS)

Jorgensen, Charles C.

1996-01-01

Neural networks are being developed at NASA Ames Research Center to permit real-time adaptive control of time varying nonlinear systems, enhance the fault-tolerance of mission hardware, and permit online system reconfiguration. In general, the problem of controlling time varying nonlinear systems with unknown structures has not been solved. Adaptive neural control techniques show considerable promise and are being applied to technical challenges including automated docking of spacecraft, dynamic balancing of the space station centrifuge, online reconfiguration of damaged aircraft, and reducing cost of new air and spacecraft designs. Our experiences have shown that neural network algorithms solved certain problems that conventional control methods have been unable to effectively address. These include damage mitigation in nonlinear reconfiguration flight control, early performance estimation of new aircraft designs, compensation for damaged planetary mission hardware by using redundant manipulator capability, and space sensor platform stabilization. This presentation explored these developments in the context of neural network control theory. The discussion began with an overview of why neural control has proven attractive for NASA application domains. The more important issues in control system development were then discussed with references to significant technical advances in the literature. Examples of how these methods have been applied were given, followed by projections of emerging application needs and directions.

Real-Time, Interactive Echocardiography Over High-Speed Networks: Feasibility and Functional Requirements

NASA Technical Reports Server (NTRS)

Bobinsky, Eric A.

1998-01-01

Real-time, Interactive Echocardiography Over High Speed Networks: Feasibility and Functional Requirements is an experiment in advanced telemedicine being conducted jointly by the NASA Lewis Research Center, the NASA Ames Research Center, and the Cleveland Clinic Foundation. In this project, a patient undergoes an echocardiographic examination in Cleveland while being diagnosed remotely by a cardiologist in California viewing a real-time display of echocardiographic video images transmitted over the broadband NASA Research and Education Network (NREN). The remote cardiologist interactively guides the sonographer administering the procedure through a two-way voice link between the two sites. Echocardiography is a noninvasive medical technique that applies ultrasound imaging to the heart, providing a "motion picture" of the heart in action. Normally, echocardiographic examinations are performed by a sonographer and cardiologist who are located in the same medical facility as the patient. The goal of telemedicine is to allow medical specialists to examine patients located elsewhere, typically in remote or medically underserved geographic areas. For example, a small, rural clinic might have access to an echocardiograph machine but not a cardiologist. By connecting this clinic to a major metropolitan medical facility through a communications network, a minimally trained technician would be able to carry out the procedure under the supervision and guidance of a qualified cardiologist.

ARC-2008-ACD08-0260-036

NASA Image and Video Library

2008-11-06

K-10 (red) robot operations tests at Marscape (Ames Mars Yard) with remote operations from Ames Future Flight Centeral (FFC) Simulator, with Melissa Rice and Harrison 'Jack' Schmitt (Apollo 17 Astronaut)

Ames Lab 101: osgBullet

ScienceCinema

McCorkle, Doug

2017-12-27

Ames Laboratory scientist Doug McCorkle explains osgBullet, a 3-D virtual simulation software, and how it helps engineers design complex products and systems in a realistic, real-time virtual environment.

Functional complexity emerging from anatomical constraints in the brain: the significance of network modularity and rich-clubs

NASA Astrophysics Data System (ADS)

Zamora-López, Gorka; Chen, Yuhan; Deco, Gustavo; Kringelbach, Morten L.; Zhou, Changsong

2016-12-01

The large-scale structural ingredients of the brain and neural connectomes have been identified in recent years. These are, similar to the features found in many other real networks: the arrangement of brain regions into modules and the presence of highly connected regions (hubs) forming rich-clubs. Here, we examine how modules and hubs shape the collective dynamics on networks and we find that both ingredients lead to the emergence of complex dynamics. Comparing the connectomes of C. elegans, cats, macaques and humans to surrogate networks in which either modules or hubs are destroyed, we find that functional complexity always decreases in the perturbed networks. A comparison between simulated and empirically obtained resting-state functional connectivity indicates that the human brain, at rest, lies in a dynamical state that reflects the largest complexity its anatomical connectome can host. Last, we generalise the topology of neural connectomes into a new hierarchical network model that successfully combines modular organisation with rich-club forming hubs. This is achieved by centralising the cross-modular connections through a preferential attachment rule. Our network model hosts more complex dynamics than other hierarchical models widely used as benchmarks.

Functional complexity emerging from anatomical constraints in the brain: the significance of network modularity and rich-clubs

PubMed Central

Zamora-López, Gorka; Chen, Yuhan; Deco, Gustavo; Kringelbach, Morten L.; Zhou, Changsong

2016-01-01

The large-scale structural ingredients of the brain and neural connectomes have been identified in recent years. These are, similar to the features found in many other real networks: the arrangement of brain regions into modules and the presence of highly connected regions (hubs) forming rich-clubs. Here, we examine how modules and hubs shape the collective dynamics on networks and we find that both ingredients lead to the emergence of complex dynamics. Comparing the connectomes of C. elegans, cats, macaques and humans to surrogate networks in which either modules or hubs are destroyed, we find that functional complexity always decreases in the perturbed networks. A comparison between simulated and empirically obtained resting-state functional connectivity indicates that the human brain, at rest, lies in a dynamical state that reflects the largest complexity its anatomical connectome can host. Last, we generalise the topology of neural connectomes into a new hierarchical network model that successfully combines modular organisation with rich-club forming hubs. This is achieved by centralising the cross-modular connections through a preferential attachment rule. Our network model hosts more complex dynamics than other hierarchical models widely used as benchmarks. PMID:27917958

ARC-2006-ACD06-0179-016

NASA Image and Video Library

2006-10-12

Ames holds a Media Day at the Hypervelocity Free Flight facility where Ames is conducting high-speed tests of small models of the agency's new Orion CEV to learn about stability during flight. The hypervelocity test facility uses a gun to shoot Orion models between 0.5 and l.5 inches (1.25 - 3.75 centimeters in diameter. The facility can conduct experiments with speeds up to 19,000 miles per hour (30,400 kilometers per hour) - Wayne Freedman, ABC Channel 7 news inerviews Jeff Brown of Ames

NASA Ames 2016 Highlights

NASA Image and Video Library

2016-12-28

2016 presented the opportunity for NASA's Ames Research Center to meet its challenges and opportunities head on. Projects ranged from testing the next generation of air traffic control software to studying the stars of our galaxy. From developing life science experiments that flew aboard the International Space Station to helping protect our planet through airborne Earth observation campaigns. NASA's missions and programs are challenging and the people at NASA Ames Research Center continue to reach new heights and reveal the unknown for the benefit of all humankind!

ARC-2009-ACD09-0261-006

NASA Image and Video Library

2009-12-10

Korean High Level Delegation Visit Ames Certer Director and variou Senior staff: from left to right; Gary Martin, Director of New Ventures and Communication, NASA. Ames, Chris Giulietti, NASA Headquarters, Soon-Duk Bae, Deputy Director, Big Science Policy Division, Ministry of Educaiton, Science Technology, Young-Mok Hyun, Deputy Director, Space Development Division, Ministry of Educaiton, Science Technology, Yvonne Pendleton, Director of Lunar Science Institute, Terry Pagaduan, Ames Government Relations/Legislative Affairs Office, Seorium Lee, Senior Researcher, International Relations Korea Aerospace Research Institute

Harrison Ford Tapes Climate Change Show at Ames (Reporter Package)

NASA Image and Video Library

2014-04-11

Hollywood legend Harrison Ford made a special visit to NASA's Ames Research Center to shoot an episode for a new documentary series about climate change called 'Years of Living Dangerously.' After being greeted by Center Director Pete Worden, Ford was filmed meeting with NASA climate scientists and discussed global temperature prediction data processed using one of the world's fastest supercomputers at Ames. Later he flew in the co-pilot seat in a jet used to gather data for NASA air quality studies.

A review of over three decades of research on cat-human and human-cat interactions and relationships.

PubMed

Turner, Dennis C

2017-08-01

This review article covers research conducted over the last three decades on cat-human and human-cat interactions and relationships, especially from an ethological point of view. It includes findings on cat-cat and cat-human communication, cat personalities and cat-owner personalities, the effects of cats on humans, and problems caused by cats. Copyright © 2017 Elsevier B.V. All rights reserved.

Cultivating a Grassroots Aerospace Innovation Culture at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

D'Souza, Sarah; Sanchez, Hugo; Lewis, Ryan

2017-01-01

This paper details the adaptation of specific 'knowledge production' methods to implement a first of its kind, grassroots event that provokes a cultural change in how the NASA Ames civil servant community engages in the creation and selection of innovative ideas. Historically, selection of innovative proposals at NASA Ames Research Center is done at the highest levels of management, isolating the views and perspectives of the larger civil servant community. Additionally, NASA innovation programs are typically open to technical organizations and do not engage non-technical organizations to bring forward innovative processes/business practices. Finally, collaboration on innovative ideas and associated solutions tend to be isolated to organizational silos. In this environment, not all Ames employees feel empowered to innovate and opportunities for employee collaboration are limited. In order to address these issues, the 'innovation contest' method was adapted to create the NASA Ames Innovation Fair, a unique, grassroots innovation opportunity for the civil servant community. The Innovation Fair consisted of a physical event with a virtual component. The physical event provided innovators the opportunity to collaborate and pitch their innovations to the NASA Ames community. The civil servant community then voted for the projects that they viewed as innovative and would contribute to NASA's core mission, making this event a truly grassroots effort. The Innovation Fair website provided a location for additional knowledge sharing, discussion, and voting. On March 3rd, 2016, the 'First Annual NASA Ames Innovation Fair' was held with 49 innovators and more than 300 participants collaborating and/or voting for the best innovations. Based on the voting results, seven projects were awarded seed funding for projects ranging from innovative cost models to innovations in aerospace technology. Surveys of both innovators and Fair participants show the Innovation Fair was successful in fostering cross-organizational collaborations, soliciting participation of non-technical innovations, and increasing employee engagement in influencing the future of NASA Ames Research Center. The grassroots component of the Innovation Fair has been bench marked by the agency as a solid foundation for increasing employee engagement in the development of game changing aerospace technology and processes in support of NASA's mission.

A Survey of Public Opinion on Cat (Felis catus) Predation and the Future Direction of Cat Management in New Zealand

PubMed Central

Walker, Jessica K.; Bruce, Stephanie J.; Dale, Arnja R.

2017-01-01

Simple Summary The need to balance the benefits of cat ownership with the prevention of wildlife predation in New Zealand evokes strong and opposing views. This paper evaluates public concern for wildlife predation by four categories of cats; owned cats, managed-stray cats, unmanaged-stray cats, and feral cats. In addition, public support for a National Cat Management Strategy and a range of management techniques are investigated. Although the participants expressed concern regarding wildlife predation by all four categories of cats, the highest levels of concern were predation by feral cats, followed by unmanaged stray cats, then managed stray cats, and finally owned cats. The large majority of participants were found to support the implementation of a National Cat Management Strategy. Management techniques for owned cats that obtained public support included; cat exclusion zones, limits on ownership numbers, microchipping, Council registration, and de-sexing. Trap-Neuter-Return (TNR) was the favoured management technique for managed stray cats, while TNR and lethal management techniques were equally favoured for unmanaged stray cats. Lethal control methods were favoured for feral cats. The findings presented in this paper will be useful to consider during the development of legislation relating to cat management and predation in New Zealand. Abstract Cat predation is a prominent issue in New Zealand that provokes strong and opposing views. We explored, via 1011 face-to-face questionnaires, public opinion on (a) support for a National Cat Management Strategy (78% support); (b) concern regarding predation of wildlife by owned and un-owned cats (managed stray, unmanaged stray, and feral cats); (c) the acceptability of management techniques for owned cats; and (d) the acceptability of population management techniques for un-owned cats. The highest concern was expressed regarding the predation of non-native and native wildlife by feral cats (60 and 86% repectively), followed by unmanaged stray cats (59 and 86% respectively), managed stray cats (54 and 82% respectively), and finally owned cats (38 and 69% repectively). Limits to the number of cats owned and cat restriction zones received high levels of support (>65%), and compulsory microchipping, Council registration, and de-sexing were supported by the majority (>58%). Public support of population control methods for unowned cats was explored, and the influence of participant demographic variables on responses is described. These findings provide insight into public opinion regarding the management of cats in New Zealand, which should be considered during the development of legislation in this area. PMID:28671609

Ames Lab 101: BAM (Boron-Aluminum-Magnesium)

ScienceCinema

Cook, Bruce

2017-12-13

Materials scientist, Bruce Cook, discusses the super hard, low friction, and lubricious alloy know as BAM (Boron-Aluminum-Magnesium). BAM was discovered by Bruce Cook and his team at the Ames Laboratory.

ARC-2008-ACD08-0260-019

NASA Image and Video Library

2008-11-04

K-10 (red) plaentary rover at Marscape (Ames Mars Yard): with prototype flight control team remotely operating K-10 'Red' from Ames Future Flight Centeral (FFC) Simulator, with Rob Landis and Steve Riley.

N-232 Sustainability Base Construction

NASA Image and Video Library

2011-11-10

Construction of the new NASA Ames Green Building dubbed Sustainability Base located on the Ames Research Center campus at Moffett Field, CA. interior view as cubicles are being set up and open spaces arranged.

Ames Lab 101: Reinventing the Power Cable

ScienceCinema

Russell, Alan

2018-01-16

Ames Laboratory researchers are working to develop new electrical power cables that are stronger and lighter than the cables currently used in the nation's power grid. Nano Tube animation by Iain Goodyear

Overview of the Telescience Testbed Program

NASA Technical Reports Server (NTRS)

Rasmussen, Daryl N.; Mian, Arshad; Leiner, Barry M.

1991-01-01

The NASA's Telescience Testbed Program (TTP) conducted by the Ames Research Center is described with particular attention to the objectives, the approach used to achieve these objectives, and the expected benefits of the program. The goal of the TTP is to gain operational experience for the Space Station Freedom and the Earth Observing System programs, using ground testbeds, and to define the information and communication systems requirements for the development and operation of these programs. The results of TTP are expected to include the requirements for the remote coaching, command and control, monitoring and maintenance, payload design, and operations management. In addition, requirements for technologies such as workstations, software, video, automation, data management, and networking will be defined.

MIDAS - A microcomputer-based image display and analysis system with full Landsat frame processing capabilities

NASA Technical Reports Server (NTRS)

Hofman, L. B.; Erickson, W. K.; Donovan, W. E.

1984-01-01

Image Display and Analysis Systems (MIDAS) developed at NASA/Ames for the analysis of Landsat MSS images is described. The MIDAS computer power and memory, graphics, resource-sharing, expansion and upgrade, environment and maintenance, and software/user-interface requirements are outlined; the implementation hardware (including 32-bit microprocessor, 512K error-correcting RAM, 70 or 140-Mbyte formatted disk drive, 512 x 512 x 24 color frame buffer, and local-area-network transceiver) and applications software (ELAS, CIE, and P-EDITOR) are characterized; and implementation problems, performance data, and costs are examined. Planned improvements in MIDAS hardware and design goals and areas of exploration for MIDAS software are discussed.

The EDSN Intersatellite Communications Architecture

NASA Technical Reports Server (NTRS)

Hanson, John; Chartres, James; Sanchez, Hugo; Oyadomari, Ken

2014-01-01

The Edison Demonstration of Smallsat Networks (EDSN) is a swarm of eight 1.5U Cubesats developed by the NASA Ames Research Center under the Small Spacecraft Technology Program (SSTP) within NASA Space Technology Mission Directorate (STMD). EDSN, scheduled for launch in late 2014, is designed to explore the use of small spacecraft networks to make synchronized, multipoint scientific measurements, and to organize and pass those data to the ground through their network. Networked swarms of these small spacecraft will open new horizons in astronomy, Earth observations and solar physics. Their range of applications include the formation of synthetic aperture radars for Earth sensing systems, large aperture observatories for next generation telescopes and the collection of spatially distributed measurements of time varying systems, probing the Earth's magnetosphere, Earth-Sun interactions and the Earth's geopotential. The EDSN communications network is maintained and operated by a simple set of predefined rules operating independently on all eight spacecraft without direction from ground based systems. One spacecraft serves as a central node, requesting and collecting data from the other seven spacecraft, organizing the data and passing it to a ground station at regular intervals. The central node is rotated among the spacecraft on a regular basis, providing robustness against the failure of a single spacecraft. This paper describes the communication architecture of the EDSN network and its operation with small spacecraft of limited electrical power, computing power and communication range. Furthermore, the problems of collecting and prioritizing data through a system that has data throughput bottlenecks are addressed. Finally, future network enhancements that can be built on top of the current EDSN hardware are discussed.

Ames Lab 101: Next Generation Power Lines

ScienceCinema

Russell, Alan

2017-12-22

Ames Laboratory scientist Alan Russell discusses the need to develop new power lines that are stronger and more conductive as a way to address the problem of the nation's aging and inadequate power grid.

State of the Lab 2012

ScienceCinema

King, Alex

2018-05-07

Ames Laboratory Director Alex King delivers the annual State of the Lab address on Thursday, May 17, 2012, the 65th Anniversary of the founding of The Ames Laboratory. This video contains highlights from the address.

Autonomy @ Ames

NASA Technical Reports Server (NTRS)

Van Dalsem, William; Krishnakumar, Kalmanje Srinivas

2016-01-01

This is a powerpoint presentation that highlights autonomy across the 15 NASA technology roadmaps, including specific examples of projects (past and present) at NASA Ames Research Center. The NASA technology roadmaps are located here: http:www.nasa.govofficesocthomeroadmapsindex.html

State of the Lab 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, Alex

2012-01-01

Ames Laboratory Director Alex King delivers the annual State of the Lab address on Thursday, May 17, 2012, the 65th Anniversary of the founding of The Ames Laboratory. This video contains highlights from the address.

ARC-2007-ACD07-0064-073

NASA Image and Video Library

2007-04-13

Yuri's Night at Ames a celebration of the first human in space. Ames Planetary Scientist with the Space Science Division Dr Chris McKay addresses a audience about Mars and life in extreme environments.

ARC-2008-ACD08-0260-040

NASA Image and Video Library

2008-11-06

K-10 (red) robot operations tests at Marscape (Ames Mars Yard) with remote operations from Ames Future Flight Centeral (FFC) Simulator, L-R; Terry Fong, Melissa Rice and Harrison 'Jack' Schmitt (Apollo 17 Astronaut).

ARC-2011-ACD11-0016-006

NASA Image and Video Library

2011-02-03

The 14 member 2009 class of NASA astronauts, Japan Aerospace Explortion Agency (JAXA) astronauts and Canadian Space Agency astronauts visit Ames Research Center. Pete Worden, Ames Center Director joins the candidates during the round table.

ARC-2008-ACD08-0219-021

NASA Image and Video Library

2008-09-26

Professor John Beddington, UK (United Kingdom) Government Chief Scientist Advisor visit to Ames on tour of the Small Satellites area Bldg 45 with ______and Ames Center Director Pete Worden (and a lunar lander prototype)

Aerial Survey of Ames Research Center - Flight Simulation Complex' Flight simulators create an

NASA Technical Reports Server (NTRS)

1967-01-01

Aerial Survey of Ames Research Center - Flight Simulation Complex' Flight simulators create an authentic aircraft environment by generating the appropriate physical cues that provide the sensations of flight.

Factors influencing young people's use of alcohol mixed with energy drinks.

PubMed

Pettigrew, Simone; Biagioni, Nicole; Jones, Sandra C; Stafford, Julia; Chikritzhs, Tanya; Daube, Mike

2016-01-01

A growing evidence base demonstrates the negative health outcomes associated with the consumption of energy drinks (ED) and alcohol mixed with energy drinks (AMED), especially among young people. Work to date has focused on the physiological effects of ED and AMED use and the motivations associated with consumption, typically among college students. The present study adopted an exploratory, qualitative approach with a community sample of 18-21 year olds to identify relevant barriers, motivators, and facilitators to AMED use and to explicate the decision-making processes involved. The sensitisation method was used to collect data from a cohort of 60 young adult drinkers over a period of six months via individual interviews, focus groups, and introspections. The findings indicate that there may be a general understanding of the negative consequences of AMED use, and that these consequences can constitute barriers that serve to discourage frequent consumption among young people. This outcome suggests the potential application of positive deviance and social norms approaches in interventions designed to reduce AMED use among this population segment. The results are promising in the identification of a large number of concerns among young adults relating to AMED use. These concerns can constitute the focus of future communications with this target group. The results are likely to have relevance to other countries, such as the US and the UK, that share similar alcohol cultures and where energy drinks have achieved comparable market penetration rates. Copyright © 2015 Elsevier Ltd. All rights reserved.

Loss of 3-D shape constancy in interior spaces: the basis of the Ames-room illusion.

PubMed

Dorward, F M; Day, R H

1997-01-01

The apparently rectangular form of the irregularly shaped Ames room is explained in terms of a loss of interior 3-D shape constancy consequent on viewing the room with one eye through a small specifically positioned aperture. In the absence of retinal disparity and motion parallax the appearance of the room is held to shift markedly toward the rectangular dimensions of its retinal image. Three experiments designed to test this explanation with a miniature (one-tenth size) version of the Ames room No 1 with the matched 2-D shape of the back wall and as an index of interior 3-D shape are reported. The experiments showed that interior constancy was almost fully restored with binocular viewing of the room (experiment 1). The effect with a 'skeletal' version of the room was about the same as that with the conventional version and was clearly evident when the back wall or its frame version was presented alone (experiment 2), and it varied according to whether the interior perspective corresponded with that of the Ames or a rectangular room (experiment 3). Experiment 3 also showed that a rectangular room is significantly distorted when the interior perspective accords with that of the Ames room. These outcomes are construed as supporting the loss-of-constancy explanation and as showing that the Ames-room effect is one of a class of illusions attributable to the absence of stimulus correlates that normally sustain visual shape constancy.

The Feline Mystique: Dispelling the Myth of the Independent Cat.

ERIC Educational Resources Information Center

Soltow, Willow

1984-01-01

Describes learning activities about cats for primary and intermediate grades. Primary grade activity subjects include cat behavior, needs, breeds, storybook cats, and celestial cats. Intermediate grade activity subjects include cat history, care, language, literary cats, and cats in art. (BC)

Comparative study of aural microflora in healthy cats, allergic cats and cats with systemic disease.

PubMed

Pressanti, Charline; Drouet, Clémence; Cadiergues, Marie-Christine

2014-12-01

Twenty healthy cats (group 1) with clinically normal ears, 15 cats with systemic disease (group 2) and 15 allergic cats (group 3) were included in a prospective study. The experimental unit was the ear. A clinical score was established for each ear canal after otoscopic examination. Microbial population was assessed on cytological examination of smears performed with the cotton-tipped applicator smear technique. Fungal population was significantly more prominent in allergic cats (P <0.001) and in diseased cats compared with healthy cats (P <0.02). Bacterial population was significantly higher in allergic cats than in healthy cats (P <0.001) and cats suffering from systemic disease (P <0.001). Bacterial overgrowth was also higher in cats with systemic disease than healthy cats. In cats from group 2, only fungal overgrowth was associated with otitis severity. In group 3, only bacterial overgrowth was associated with otitis severity. © ISFM and AAFP 2014.

Cat Ownership Perception and Caretaking Explored in an Internet Survey of People Associated with Cats

PubMed Central

Zito, Sarah; Vankan, Dianne

2015-01-01

People who feed cats that they do not perceive they own (sometimes called semi-owners) are thought to make a considerable contribution to unwanted cat numbers because the cats they support are generally not sterilized. Understanding people’s perception of cat ownership and the psychology underlying cat semi-ownership could inform approaches to mitigate the negative effects of cat semi-ownership. The primary aims of this study were to investigate cat ownership perception and to examine its association with human-cat interactions and caretaking behaviours. A secondary aim was to evaluate a definition of cat semi-ownership (including an association time of ≥1 month and frequent feeding), revised from a previous definition proposed in the literature to distinguish cat semi-ownership from casual interactions with unowned cats. Cat owners and semi-owners displayed similar types of interactions and caretaking behaviours. Nevertheless, caretaking behaviours were more commonly displayed towards owned cats than semi-owned cats, and semi-owned cats were more likely to have produced kittens (p<0.01). All interactions and caretaking behaviours were more likely to be displayed towards cats in semi-ownership relationships compared to casual interaction relationships. Determinants of cat ownership perception were identified (p<0.05) and included association time, attachment, perceived cat friendliness and health, and feelings about unowned cats, including the acceptability of feeding unowned cats. Encouraging semi-owners to have the cats they care for sterilized may assist in reducing the number of unwanted kittens and could be a valuable alternative to trying to prevent semi-ownership entirely. Highly accessible semi-owner “gatekeepers” could help to deliver education messages and facilitate the provision of cat sterilization services to semi-owners. This research enabled semi-ownership to be distinguished from casual interaction relationships and can assist welfare and government agencies to identify cat semi-owners in order to develop strategies to address this source of unwanted cats. PMID:26218243

Developing a computer-controlled simulated digestion system to predict the concentration of metabolizable energy of feedstuffs for rooster.

PubMed

Zhao, F; Ren, L Q; Mi, B M; Tan, H Z; Zhao, J T; Li, H; Zhang, H F; Zhang, Z Y

2014-04-01

Four experiments were conducted to evaluate the effectiveness of a computer-controlled simulated digestion system (CCSDS) for predicting apparent metabolizable energy (AME) and true metabolizable energy (TME) using in vitro digestible energy (IVDE) content of feeds for roosters. In Exp. 1, the repeatability of the IVDE assay was tested in corn, wheat, rapeseed meal, and cottonseed meal with 3 assays of each sample and each with 5 replicates of the same sample. In Exp. 2, the additivity of IVDE concentration in corn, soybean meal, and cottonseed meal was tested by comparing determined IVDE values of the complete diet with values predicted from measurements on individual ingredients. In Exp. 3, linear models to predict AME and TME based on IVDE were developed with 16 calibration samples. In Exp. 4, the accuracy of prediction models was tested by the differences between predicted and determined values for AME or TME of 6 ingredients and 4 diets. In Exp. 1, the mean CV of IVDE was 0.88% (range = 0.20 to 2.14%) for corn, wheat, rapeseed meal, and cottonseed meal. No difference in IVDE was observed between 3 assays of an ingredient, indicating that the IVDE assay is repeatable under these conditions. In Exp. 2, minimal differences (<21 kcal/kg) were observed between determined and calculated IVDE of 3 complete diets formulated with corn, soybean meal, and cottonseed meal, demonstrating that the IVDE values are additive in a complete diet. In Exp. 3, linear relationships between AME and IVDE and between TME and IVDE were observed in 16 calibration samples: AME = 1.062 × IVDE - 530 (R(2) = 0.97, residual standard deviation [RSD] = 146 kcal/kg, P < 0.001) and TME = 1.050 × IVDE - 16 (R(2) = 0.97, RSD = 148 kcal/kg, P < 0.001). Differences of less than 100 kcal/kg were observed between determined and predicted values in 10 and 9 of the 16 calibration samples for AME and TME, respectively. In Exp. 4, differences of less than 100 kcal/kg between determined and predicted values were observed in 3 and 4 of the 6 ingredient samples for AME and TME, respectively, and all 4 diets showed the differences of less than 25 kcal/kg between determined and predicted AME or TME. Our results indicate that the CCSDS is repeatable and additive. This system accurately predicted AME or TME on 17 of the 26 samples and may be a promising method to predict the energetic values of feed for poultry.

Direction discrimination learning in normal and visually deprived cats and the effects of lateral suprasylvian lesions.

PubMed

Burnat, K; Zernicki, B

1997-01-01

We used 5 binocularly deprived cats (BD cats), 4 control cats reared also in the laboratory (C cats) and 4 cats reared in a normal environment (N cats). The cats were trained to discriminate an upward or downward-moving light spot versus a stationary spot (detection task) and then an upward versus a downward spot (direction task). The N and C cats learned slowly. The learning was slower than in previously studied discriminations of stationary stimuli. However, all N and C cats mastered the detection task and except one C cat the direction task. In contrast, 4 BD cats failed in the detection task and all in the direction task. This result is consistent with single-cell recording data showing impairment of direction analysis in the visual system in BD cats. After completing the training the upper part of the middle suprasylvian sulcus was removed unilaterally in 7 cats and bilaterally in 6 cats. Surprisingly, the unilateral lesions were more effective: the clear-cut retention deficits were found in 5 cats lesioned unilaterally, whereas only in one cat lesioned bilaterally.

Mechanism of Flavoprotein l-6-Hydroxynicotine Oxidase: pH and Solvent Isotope Effects and Identification of Key Active Site Residues.

PubMed

Fitzpatrick, Paul F; Chadegani, Fatemeh; Zhang, Shengnan; Dougherty, Vi

2017-02-14

The flavoenzyme l-6-hydroxynicotine oxidase is a member of the monoamine oxidase family that catalyzes the oxidation of (S)-6-hydroxynicotine to 6-hydroxypseudooxynicotine during microbial catabolism of nicotine. While the enzyme has long been understood to catalyze oxidation of the carbon-carbon bond, it has recently been shown to catalyze oxidation of a carbon-nitrogen bond [Fitzpatrick, P. F., et al. (2016) Biochemistry 55, 697-703]. The effects of pH and mutagenesis of active site residues have now been utilized to study the mechanism and roles of active site residues. Asn166 and Tyr311 bind the substrate, while Lys287 forms a water-mediated hydrogen bond with flavin N5. The N166A and Y311F mutations result in ∼30- and ∼4-fold decreases in k cat /K m and k red for (S)-6-hydroxynicotine, respectively, with larger effects on the k cat /K m value for (S)-6-hydroxynornicotine. The K287M mutation results in ∼10-fold decreases in these parameters and a 6000-fold decrease in the k cat /K m value for oxygen. The shapes of the pH profiles are not altered by the N166A and Y311F mutations. There is no solvent isotope effect on the k cat /K m value for amines. The results are consistent with a model in which both the charged and neutral forms of the amine can bind, with the former rapidly losing a proton to a hydrogen bond network of water and amino acids in the active site prior to the transfer of hydride to the flavin.

Ames Laboratory site environmental report, calendar year 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mathison, L.K.

1989-05-01

The summarized data and conclusions from the Ames Laboratory environmental monitoring program are presented in this Annual Site Environmental Report. Ames Laboratory is located on the campus of Iowa State University (ISU) and occupies several buildings owned by the Department of Energy. A study is being conducted to identify environmental sampling methods which can characterize and separate the impact of Ames Laboratory's campus activities and that of ISU. This will enable the Laboratory to determine what possible impact it's operations may be having to the environment, if any. Two Pollution Abatement projects were begun in 1988. They were: removal ofmore » thorium contaminated soil resulting from a historical release of thorium at the Laboratory, to the Ames, Iowa Water Pollution Control (sewage) Plant and demolition of a small Blockhouse'' constructed of concrete block which had been used for low level radioactive waste handling. The contaminated soil has been removed and transported to Hanford, WA for disposal. A final site radiological survey for thorium is pending. In addition, contaminated debris was transported to Hanford, WA for disposal and a final site survey is pending. 7 refs., 4 figs., 1 tab.« less

Recovery of locomotion in the cat following spinal cord lesions.

PubMed

Rossignol, S; Bouyer, L; Barthélemy, D; Langlet, C; Leblond, H

2002-10-01

In most species, locomotor function beneath the level of a spinal cord lesion can be restored even if the cord is completely transected. This suggests that there is, within the spinal cord, an autonomous network of neurons capable of generating a locomotor pattern independently of supraspinal inputs. Recent studies suggest that several physiological and neurochemical changes have to occur in the neuronal networks located caudally to the lesion to allow the expression of spinal locomotion. Some evidence of this plasticity will be addressed in this review. In addition, original data on the functional organisation of the lumbar spinal cord will also be presented. Recent works in our lab show that segmental responsiveness of the spinal cord of the cat to locally micro-injected drugs in different lumbar segments, in combination with complete lesions at various level of the spinal cord, suggest a rostro-caudal organisation of spinal locomotor control. Moreover, the integrity of midlumbar segments seems to be crucial for the expression of spinal locomotion. These data suggest that the regions of critical importance for locomotion can be confined to a restricted portion of the spinal cord. Later, these midlumbar segments could be targeted by electrical stimulation or grafts to improve recovery of function. Understanding the changes in spinal cord neurophysiology and neurochemistry after a lesion is of critical importance to the improvement of treatments for locomotor rehabilitation in spinal-cord-injured patients.

ARC-1999-AC99-0013-4

NASA Image and Video Library

1999-01-26

Prince Willem-Alexander van Oranje (Crown Prince of the Netherlands) visits Ames. Shown here with Dr Henry McDonald, Ames Director in lobby of N-243. His visit was prompted by his strong personal interest in aviation.

ARC-2007-ACD07-0145-001

NASA Image and Video Library

2007-08-01

NASA Officials gather at Ames Research Center to discuss Spaceship development progress. Constellation is developing the Orion spacecraft and Ares rockets to support an American return to the moon by 2020. Dolores Beasley, Director NASA Ames PAO

ARC-2007-ACD07-0145-002

NASA Image and Video Library

2007-08-01

NASA Officials gather at Ames Research Center to discuss Spaceship development progress. Constellation is developing the Orion spacecraft and Ares rockets to support an American return to the moon by 2020. Dolores Beasley, Director NASA Ames PAO

ARC-2007-ACD07-0092-038

NASA Image and Video Library

2007-05-24

Dr Condoleezza Rice, United States Secretary of State visits Ames. Takes a demonstration ride in the Tesla Motors Electric Car. Australian Foreign Minister Alexander Downer traveling with Dr Rice addresses the assembled media and Ames staffers

Ames research center publications, 1975

NASA Technical Reports Server (NTRS)

Sherwood, B. R. (Compiler)

1977-01-01

This bibliography cites 851 documents by Ames Research Center personnel and contractors which appeared in formal NASA publications, journals, books, patents, and contractor reports in 1975, or not included in previous annual bibliographies. An author index is provided.

ARC-2008-ACD08-0260-022

NASA Image and Video Library

2008-11-04

K-10 (red) plaentary rover at Marscape (Ames Mars Yard): with prototype flight control team remotely operating K-10 'Red' from Ames Future Flight Centeral (FFC) Simulator, L-R; Pascal Lee, Melissa Rice, David Lees, Trey Smith

17. Woodworking Mill (basement): view looking north showing Ames Iron ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Woodworking Mill (basement): view looking north showing Ames Iron Works steam boiler; note turbine control handle in middle right of photo - Ben Thresher's Mill, State Aid No. 1, Barnet, Caledonia County, VT

ARC-2002-ACD02-0015-070

NASA Image and Video Library

2002-02-01

NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Here he welcomes JASON kids to NASA while handing out patches and pins. Tom Clausen and Donald James, Ames Education Office in background.

Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

NASA Image and Video Library

2017-02-15

(Left): Kyle Botteon (front) and Hunjpp Kim (Behind), NASA JPL. (Right): Gregory Zilliac, Advance Propulsion Technician. NASA Ames, preparing the Peregrine Hybrid Rocket Engine at the Outdoor Aerodynamic Research Facility (OARF, N-249).

ARC-2007-ACD07-0089-364

NASA Image and Video Library

2007-05-11

Disaster preparedness; 'The Great Worden Quake of 2007' Ames Research Center resident staff participate in responding to a simulated disaster, followed by a picnic in front of bldg N-200. Ames DART rescue teams - Deb Feng

ARC-1985-AC85-0186-2

NASA Image and Video Library

1985-03-12

XV-15 Tilt Rotor (NASA-703) in flight at Ames Research Center Note: Used in publication in Flight Research at Ames; 57 Years of Development and Validation of Aeronautical Technology NASA SP-1998-3300 fig 122

Computational Methods Development at Ames

NASA Technical Reports Server (NTRS)

Kwak, Dochan; Smith, Charles A. (Technical Monitor)

1998-01-01

This viewgraph presentation outlines the development at Ames Research Center of advanced computational methods to provide appropriate fidelity computational analysis/design capabilities. Current thrusts of the Ames research include: 1) methods to enhance/accelerate viscous flow simulation procedures, and the development of hybrid/polyhedral-grid procedures for viscous flow; 2) the development of real time transonic flow simulation procedures for a production wind tunnel, and intelligent data management technology; and 3) the validation of methods and the flow physics study gives historical precedents to above research, and speculates on its future course.

The Center for Star Formation Studies

NASA Technical Reports Server (NTRS)

Hollenbach, D.; Bell, K. R.; Laughlin, G.

2002-01-01

The Center for Star Formation Studies, a consortium of scientists from the Space Science Division at Ames and the Astronomy Departments of the University of California at Berkeley and Santa Cruz, conducts a coordinated program of theoretical research on star and planet formation. Under the directorship of D. Hollenbach (Ames), the Center supports postdoctoral fellows, senior visitors, and students; meets regularly at Ames to exchange ideas and to present informal seminars on current research; hosts visits of outside scientists; and conducts a week-long workshop on selected aspects of star and planet formation each summer.

Application of CFD in aeronautics at NASA Ames Research Center

NASA Astrophysics Data System (ADS)

Maksymiuk, Catherine M.; Enomoto, Francis Y.; Vandalsem, William R.

1995-03-01

The role of Computational Fluid Dynamics (CFD) at Ames Research Center has expanded to address a broad range of aeronautical problems, including wind tunnel support, flight test support, design, and analysis. Balancing the requirements of each new problem against the available resources - software, hardware, time, and expertise - is critical to the effective use of CFD. Several case studies of recent applications highlight the depth of CFD capability at Ames, the tradeoffs involved in various approaches, and lessons learned in the use of CFD as an engineering tool.

NASA Ames Science Instrument Launches Aboard New Mars Rover (CheMin)

NASA Image and Video Library

2011-11-23

When NASA's Mars Science Laboratory lands in a region known as Gale Crater in August of 2012, it will be poised to carry out the most sophisticated chemical analysis of the Martian surface to date. One of the 10 instruments on board the rover Curiosity will be CheMin - short for chemistry and mineralogy. Developed by Ames researcher David Blake and his team, it will use new technology to analyze and identify minerals in the Martian rocks and soil. Youtube: NASA Ames Scientists Develop MSL Science Instrument

The NASA Ames Hypervelocity Free Flight Aerodynamic Facility: Experimental Simulation of the Atmospheric Break-Up of Meteors

NASA Technical Reports Server (NTRS)

Wilder, M. C.; Bogdanoff, D. W.

2015-01-01

The Hypervelocity Free Flight Aerodynamic Facility at NASA Ames Research Center provides a potential platform for the experimental simulation of meteor breakup at conditions that closely match full-scale entry condition for select parameters. The poster describes the entry environment simulation capabilities of the Hypervelocity Free Flight Aerodynamic Facility (HFFAF) at NASA Ames Research Center and provides example images of the fragmentation of a hypersonic projectile for which break-up was initiated by mechanical forces (impact with a thin polymer diaphragm).

Diverse Studies in the Reactivated NASA/Ames Radiation Facility: From Shock Layer Spectroscopy to Thermal Protection System Impact

NASA Technical Reports Server (NTRS)

Miller, Robert J.; Hartman, G. Joseph (Technical Monitor)

1994-01-01

NASA/Ames' Hypervelocity Free-Flight Radiation Facility has been reactivated after having been decommissioned for some 15 years, first tests beginning in early 1994. This paper discusses two widely different studies from the first series, one involving spectroscopic analysis of model shock-layer radiation, and the other the production of representative impact damage in space shuttle thermal protection tiles for testing in the Ames arc-jet facilities. These studies emphasize the interorganizational and interdisciplinary value of the facility in the newly-developing structure of NASA.

A SOA broker solution for standard discovery and access services: the GI-cat framework

NASA Astrophysics Data System (ADS)

Boldrini, Enrico

2010-05-01

GI-cat ideal users are data providers or service providers within the geoscience community. The former have their data already available through an access service (e.g. an OGC Web Service) and would have it published through a standard catalog service, in a seamless way. The latter would develop a catalog broker and let users query and access different geospatial resources through one or more standard interfaces and Application Profiles (AP) (e.g. OGC CSW ISO AP, CSW ebRIM/EO AP, etc.). GI-cat actually implements a broker components (i.e. a middleware service) which carries out distribution and mediation functionalities among "well-adopted" catalog interfaces and data access protocols. GI-cat also publishes different discovery interfaces: the OGC CSW ISO and ebRIM Application Profiles (the latter coming with support for the EO and CIM extension packages) and two different OpenSearch interfaces developed in order to explore Web 2.0 possibilities. An extended interface is also available to exploit all available GI-cat features, such as interruptible incremental queries and queries feedback. Interoperability tests performed in the context of different projects have also pointed out the importance to enforce compatibility with existing and wide-spread tools of the open source community (e.g. GeoNetwork and Deegree catalogs), which was then achieved. Based on a service-oriented framework of modular components, GI-cat can effectively be customized and tailored to support different deployment scenarios. In addition to the distribution functionality an harvesting approach has been lately experimented, allowing the user to switch between a distributed and a local search giving thus more possibilities to support different deployment scenarios. A configurator tool is available in order to enable an effective high level configuration of the broker service. A specific geobrowser was also naturally developed, for demonstrating the advanced GI-cat functionalities. This client, called GI-go, is an example of the possible applications which may be built on top of the GI-cat broker component. GI-go allows discovering and browsing of the available datasets, retrieving and evaluating their description and performing distributed queries according to any combination of the following criteria: geographic area, temporal interval, topic of interest (free-text and/or keyword selection are allowed) and data source (i.e. where, when, what, who). The results set of a query (e.g. datasets metadata) are then displayed in an incremental way leveraging the asynchronous interactions approach implemented by GI-cat. This feature allows the user to access the intermediate query results. Query interruption and feedback features are also provided to the user. Alternatively, user may perform a browsing task by selecting a catalog resource from the current configuration and navigate through its aggregated and/or leaf datasets. In both cases datasets metadata, expressed according to ISO 19139 (and also Dublin Core and ebRIM if available), are displayed for download, along with a resource portrayal and actual data access (when this is meaningful and possible). The GI-cat distributed catalog service has been successfully deployed and experimented in the framework of different projects and initiative, including the SeaDataNet FP6 project, GEOSS IP3 (Interoperability Process Pilot Project), GEOSS AIP-2 (Architectural Implementation Project - Phase 2), FP7 GENESI-DR, CNR GIIDA, FP7 EUROGEOSS and ESA HMA project.

Bifurcation-based adiabatic quantum computation with a nonlinear oscillator network.

PubMed

Goto, Hayato

2016-02-22

The dynamics of nonlinear systems qualitatively change depending on their parameters, which is called bifurcation. A quantum-mechanical nonlinear oscillator can yield a quantum superposition of two oscillation states, known as a Schrödinger cat state, via quantum adiabatic evolution through its bifurcation point. Here we propose a quantum computer comprising such quantum nonlinear oscillators, instead of quantum bits, to solve hard combinatorial optimization problems. The nonlinear oscillator network finds optimal solutions via quantum adiabatic evolution, where nonlinear terms are increased slowly, in contrast to conventional adiabatic quantum computation or quantum annealing, where quantum fluctuation terms are decreased slowly. As a result of numerical simulations, it is concluded that quantum superposition and quantum fluctuation work effectively to find optimal solutions. It is also notable that the present computer is analogous to neural computers, which are also networks of nonlinear components. Thus, the present scheme will open new possibilities for quantum computation, nonlinear science, and artificial intelligence.

Bifurcation-based adiabatic quantum computation with a nonlinear oscillator network

NASA Astrophysics Data System (ADS)

Goto, Hayato

2016-02-01

The dynamics of nonlinear systems qualitatively change depending on their parameters, which is called bifurcation. A quantum-mechanical nonlinear oscillator can yield a quantum superposition of two oscillation states, known as a Schrödinger cat state, via quantum adiabatic evolution through its bifurcation point. Here we propose a quantum computer comprising such quantum nonlinear oscillators, instead of quantum bits, to solve hard combinatorial optimization problems. The nonlinear oscillator network finds optimal solutions via quantum adiabatic evolution, where nonlinear terms are increased slowly, in contrast to conventional adiabatic quantum computation or quantum annealing, where quantum fluctuation terms are decreased slowly. As a result of numerical simulations, it is concluded that quantum superposition and quantum fluctuation work effectively to find optimal solutions. It is also notable that the present computer is analogous to neural computers, which are also networks of nonlinear components. Thus, the present scheme will open new possibilities for quantum computation, nonlinear science, and artificial intelligence.

Neural network models for spatial data mining, map production, and cortical direction selectivity

NASA Astrophysics Data System (ADS)

Parsons, Olga

A family of ARTMAP neural networks for incremental supervised learning has been developed over the last decade. The Sensor Exploitation Group of MIT Lincoln Laboratory (LL) has incorporated an early version of this network as the recognition engine of a hierarchical system for fusion and data mining of multiple registered geospatial images. The LL system has been successfully fielded, but it is limited to target vs. non-target identifications and does not produce whole maps. This dissertation expands the capabilities of the LL system so that it learns to identify arbitrarily many target classes at once and can thus produce a whole map. This new spatial data mining system is designed particularly to cope with the highly skewed class distributions of typical mapping problems. Specification of a consistent procedure and a benchmark testbed has permitted the evaluation of candidate recognition networks as well as pre- and post-processing and feature extraction options. The resulting default ARTMAP network and mapping methodology set a standard for a variety of related mapping problems and application domains. The second part of the dissertation investigates the development of cortical direction selectivity. The possible role of visual experience and oculomotor behavior in the maturation of cells in the primary visual cortex is studied. The responses of neurons in the thalamus and cortex of the cat are modeled when natural scenes are scanned by several types of eye movements. Inspired by the Hebbian-like synaptic plasticity, which is based upon correlations between cell activations, the second-order statistical structure of thalamo-cortical activity is examined. In the simulations, patterns of neural activity that lead to a correct refinement of cell responses are observed during visual fixation, when small ocular movements occur, but are not observed in the presence of large saccades. Simulations also replicate experiments in which kittens are reared under stroboscopic illumination. The abnormal fixational eye movements of these cats may account for the puzzling finding of a specific loss of cortical direction selectivity but preservation of orientation selectivity. This work indicates that the oculomotor behavior of visual fixation may play an important role in the refinement of cell response selectivity.

RIACS

NASA Technical Reports Server (NTRS)

Moore, Robert C.

1998-01-01

The Research Institute for Advanced Computer Science (RIACS) was established by the Universities Space Research Association (USRA) at the NASA Ames Research Center (ARC) on June 6, 1983. RIACS is privately operated by USRA, a consortium of universities that serves as a bridge between NASA and the academic community. Under a five-year co-operative agreement with NASA, research at RIACS is focused on areas that are strategically enabling to the Ames Research Center's role as NASA's Center of Excellence for Information Technology. Research is carried out by a staff of full-time scientist,augmented by visitors, students, post doctoral candidates and visiting university faculty. The primary mission of RIACS is charted to carry out research and development in computer science. This work is devoted in the main to tasks that are strategically enabling with respect to NASA's bold mission in space exploration and aeronautics. There are three foci for this work: Automated Reasoning. Human-Centered Computing. and High Performance Computing and Networking. RIACS has the additional goal of broadening the base of researcher in these areas of importance to the nation's space and aeronautics enterprises. Through its visiting scientist program, RIACS facilitates the participation of university-based researchers, including both faculty and students, in the research activities of NASA and RIACS. RIACS researchers work in close collaboration with NASA computer scientists on projects such as the Remote Agent Experiment on Deep Space One mission, and Super-Resolution Surface Modeling.

2002 Computing and Interdisciplinary Systems Office Review and Planning Meeting

NASA Technical Reports Server (NTRS)

Lytle, John; Follen, Gregory; Lopez, Isaac; Veres, Joseph; Lavelle, Thomas; Sehra, Arun; Freeh, Josh; Hah, Chunill

2003-01-01

The technologies necessary to enable detailed numerical simulations of complete propulsion systems are being developed at the NASA Glenn Research Center in cooperation with NASA Glenn s Propulsion program, NASA Ames, industry, academia and other government agencies. Large scale, detailed simulations will be of great value to the nation because they eliminate some of the costly testing required to develop and certify advanced propulsion systems. In addition, time and cost savings will be achieved by enabling design details to be evaluated early in the development process before a commitment is made to a specific design. This year s review meeting describes the current status of the NPSS and the Object Oriented Development Kit with specific emphasis on the progress made over the past year on air breathing propulsion applications for aeronautics and space transportation applications. Major accomplishments include the first 3-D simulation of the primary flow path of a large turbofan engine in less than 15 hours, and the formal release of the NPSS Version 1.5 that includes elements of rocket engine systems and a visual based syntax layer. NPSS and the Development Kit are managed by the Computing and Interdisciplinary Systems Office (CISO) at the NASA Glenn Research Center and financially supported in fiscal year 2002 by the Computing, Networking and Information Systems (CNIS) project managed at NASA Ames, the Glenn Aerospace Propulsion and Power Program and the Advanced Space Transportation Program.

Cat's medullary reticulospinal and subnucleus reticularis dorsalis noxious neurons form a coupled neural circuit through collaterals of descending axons

PubMed Central

Leiras, Roberto; Martín-Cora, Francisco; Velo, Patricia; Liste, Tania

2015-01-01

Animals and human beings sense and react to real/potential dangerous stimuli. However, the supraspinal mechanisms relating noxious sensing and nocifensive behavior are mostly unknown. The collateralization and spatial organization of interrelated neurons are important determinants of coordinated network function. Here we electrophysiologically studied medial medullary reticulospinal neurons (mMRF-RSNs) antidromically identified from the cervical cord of anesthetized cats and found that 1) more than 40% (79/183) of the sampled mMRF-RSNs emitted bifurcating axons running within the dorsolateral (DLF) and ventromedial (VMF) ipsilateral fascicles; 2) more than 50% (78/151) of the tested mMRF-RSNs with axons running in the VMF collateralized to the subnucleus reticularis dorsalis (SRD) that also sent ipsilateral descending fibers bifurcating within the DLF and the VMF. This percentage of mMRF collateralization to the SRD increased to more than 81% (53/65) when considering the subpopulation of mMRF-RSNs responsive to noxiously heating the skin; 3) reciprocal monosynaptic excitatory relationships were electrophysiologically demonstrated between noxious sensitive mMRF-RSNs and SRD cells; and 4) injection of the anterograde tracer Phaseolus vulgaris leucoagglutinin evidenced mMRF to SRD and SRD to mMRF projections contacting the soma and proximal dendrites. The data demonstrated a SRD-mMRF network interconnected mainly through collaterals of descending axons running within the VMF, with the subset of noxious sensitive cells forming a reverberating circuit probably amplifying mutual outputs simultaneously regulating motor activity and spinal noxious afferent input. The results provide evidence that noxious stimulation positively engages a reticular SRD-mMRF-SRD network involved in pain-sensory-to-motor transformation and modulation. PMID:26581870

Hemispheric lateralization in top-down attention during spatial relation processing: a Granger causal model approach.

PubMed

Falasca, N W; D'Ascenzo, S; Di Domenico, A; Onofrj, M; Tommasi, L; Laeng, B; Franciotti, R

2015-04-01

Magnetoencephalography was recorded during a matching-to-sample plus cueing paradigm, in which participants judged the occurrence of changes in either categorical (CAT) or coordinate (COO) spatial relations. Previously, parietal and frontal lobes were identified as key areas in processing spatial relations and it was shown that each hemisphere was differently involved and modulated by the scope of the attention window (e.g. a large and small cue). In this study, Granger analysis highlighted the patterns of causality among involved brain areas--the direction of information transfer ran from the frontal to the visual cortex in the right hemisphere, whereas it ran in the opposite direction in the left side. Thus, the right frontal area seems to exert top-down influence, supporting the idea that, in this task, top-down signals are selectively related to the right side. Additionally, for CAT change preceded by a small cue, the right frontal gyrus was not involved in the information transfer, indicating a selective specialization of the left hemisphere for this condition. The present findings strengthen the conclusion of the presence of a remarkable hemispheric specialization for spatial relation processing and illustrate the complex interactions between the lateralized parts of the neural network. Moreover, they illustrate how focusing attention over large or small regions of the visual field engages these lateralized networks differently, particularly in the frontal regions of each hemisphere, consistent with the theory that spatial relation judgements require a fronto-parietal network in the left hemisphere for categorical relations and on the right hemisphere for coordinate spatial processing. © 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Effect of single-cat versus multi-cat home history on perceived behavioral stress in domestic cats (Felis silvestrus catus) in an animal shelter.

PubMed

Broadley, Heidi M; McCobb, Emily C; Slater, Margaret R

2014-02-01

This study investigates the effect of living with other cats in a prior home on stress levels of cats recently surrendered to an animal shelter. A total of 63 cats was evaluated using a Cat-Stress-Score and an approach test. Cats were categorized in terms of previous home history with or without other cats. No significant difference was found in stress scores between cats from single-cat households and those from multiple-cat households, although single cats that had been in the shelter less than 4 days demonstrated higher stress levels. No significant difference was found between the two groups in terms of approach results. Results of this study suggest that, in traditional individual cage settings, cats that are not accustomed to living with other cats may experience more stress in the initial few days of attempting to adjust to shelter existence. Through the use of such assessments, shelter personnel may develop an increased awareness to the needs of these cats and attempt to provide measures to improve their well-being within the shelter environment.

Risk factors for relinquishment of cats to an animal shelter.

PubMed

Patronek, G J; Glickman, L T; Beck, A M; McCabe, G P; Ecker, C

1996-08-01

To identify feline and household characteristics associated with relinquishment of a pet cat to an animal shelter. Case-control study. Households that relinquished cats for adoption (case households) and a random sample of current cat-owning households in the same community (control households). Potentially modifiable risk factors with the highest population attributable risk for relinquishment were owners having specific expectations about the cat's role in the household, allowing the cat outdoors, owning a sexually intact cat, never having read a book about cat behavior, cats having daily or weekly inappropriate elimination, and inappropriate care expectations. Frequency of inappropriate elimination and aggression toward people were not associated with declaw status, but these behaviors were more common among sexually intact cats, compared with sterilized cats. Owners of cats in case households were more likely than owners in control households to cite cost of sterilization as a reason a cat was sexually intact. Cats found as strays and cats acquired with minimal planning were at decreased risk of relinquishment. The identified risk factors can be modified by cat owners and veterinarians to decrease the estimated 4 million cats euthanatized annually in animal shelters. Owner education programs are needed as well as increased awareness on the part of cat owners and veterinarians of the importance of resolving feline inappropriate elimination problems.

Acute measles encephalitis in partially vaccinated adults.

PubMed

Fox, Annette; Hung, Than Manh; Wertheim, Heiman; Hoa, Le Nguyen Minh; Vincent, Angela; Lang, Bethan; Waters, Patrick; Ha, Nguyen Hong; Trung, Nguyen Vu; Farrar, Jeremy; Van Kinh, Nguyen; Horby, Peter

2013-01-01

The pathogenesis of acute measles encephalitis (AME) is poorly understood. Treatment with immune-modulators is based on theories that post-infectious autoimmune responses cause demyelination. The clinical course and immunological parameters of AME were examined during an outbreak in Vietnam. Fifteen measles IgM-positive patients with confusion or Glasgow Coma Scale (GCS) score below 13, and thirteen with uncomplicated measles were enrolled from 2008-2010. Standardized clinical exams were performed and blood collected for lymphocyte and measles- and auto-antibody analysis. The median age of AME patients was 21 years, similar to controls. Eleven reported receiving measles vaccination when aged one year. Confusion developed a median of 4 days after rash. Six patients had GCS <8 and four required mechanical ventilation. CSF showed pleocytosis (64%) and proteinorrhachia (71%) but measles virus RNA was not detected. MRI revealed bilateral lesions in the cerebellum and brain stem in some patients. Most received dexamethasone +/- IVIG within 4 days of admission but symptoms persisted for ≥3 weeks in five. The concentration of voltage gated calcium channel-complex-reactive antibodies was 900 pM in one patient, and declined to 609 pM ∼ 3 months later. Measles-reactive IgG antibody avidity was high in AME patients born after vaccine coverage exceeded 50% (∼ 25 years earlier). AME patients had low CD4 (218/µl, p = 0.029) and CD8 (200/µl, p = 0.012) T-cell counts compared to controls. Young adults presenting with AME in Vietnam reported a history of one prior measles immunization, and those aged <25 years had high measles-reactive IgG avidity indicative of prior vaccination. This suggests that one-dose measles immunization is not sufficient to prevent AME in young adults and reinforces the importance of maintaining high coverage with a two-dose measles immunization schedule. Treatment with corticosteroids and IVIG is common practice, and should be assessed in randomized clinical trials.

Feral Cats: Too Long a Threat to Hawaiian Wildlife

USGS Publications Warehouse

Hess, Steven C.; Banko, Paul C.

2006-01-01

BACKGROUND Domestic cats (Felis catus) were first brought to Hawai`i aboard sailing ships of European explorers and colonists. The job of these predators was to control mice and rats on the ships during the long voyages. As in other places, cats were taken in and adopted by the families of Hawai`i and soon became household pets known as popoki. But cats have always been very well equipped to live and hunt on their own. On tropical archipelagos like the Hawaiian Islands where no other predatory mammals of comparable size existed, abundant and naive prey were particularly easy game, and cats soon thrived in the wild. Although the details of when cats first came to live in the wild remain little known, adventurers, writers, and naturalists of the day recorded some important observations. Feral cats were observed in remote wilderness around K?ilauea volcano on Hawai`i Island as early as 1840 by explorer William Brackenridge. Mark Twain was so impressed by the great abundance of cats when he visited Honolulu in 1866 that he reported his observations in the Sacramento Union newspaper, which were later reprinted in his book Roughing It: I saw... tame cats, wild cats, singed cats, individual cats, groups of cats, platoons of cats, companies of cats, regiments of cats, armies of cats, multitudes of cats, millions of cats...

Demographics, lifestyle and veterinary care of cats in Australia and New Zealand.

PubMed

Johnston, Laura; Szczepanski, Julia; McDonagh, Phillip

2017-12-01

Objectives The aim of this survey was to provide up-to-date information on the demographics, lifestyle and veterinary care of cats in Australia and New Zealand. Methods An online survey consisting of 19 questions was created using SurveyMonkey. Cat owners were invited to participate through advertisements in veterinary clinics and social media. Results The average number of cats in a household was two. The majority of cats lived in free-standing houses (78%) in the suburbs (66%). The majority of cats were desexed (94% [49% female neutered; 45% male neutered]). A total of 57% of cats had been strays or came from an animal shelter. A total of 40% of owners had intended not to let the cats outside when they first acquired them. A total of 63% of cats were described as indoor-outdoor cats. Although owners described 34% of cats as 'indoor only', 58% of those cats had access to the outdoors. The majority of respondents' cats were vaccinated annually (63%) and visited a vet at least annually (79%). The most common reasons to take a cat to the vet were vaccinations or the cat being unwell. The most common reasons not to regularly take the cat to the vet were that the cat was never unwell, cost or stress for the cat. Conclusions and relevance Consideration of the lifestyle of cats is important to optimise veterinary care. Cats across Australia and New Zealand have a variety of different and changing lifestyles. Therefore, careful owner questioning is required at each visit to maximise healthcare outcomes for cats.

Effects of a synthetic facial pheromone on behavior of cats.

PubMed

Griffith, C A; Steigerwald, E S; Buffington, C A

2000-10-15

TO evaluate the effects of a synthetic feline facial pheromone (FFP) on behavior and food intake of healthy versus clinically ill cats. Original study. 20 cats were used in each of 2 studies. In each study, 7 cats were considered healthy, and 13 cats were determined to be clinically ill. In study 1, cats were assigned either to exposure to FFP (treated group; 4 healthy, 6 ill cats) or to exposure to the vehicle (70% ethanol solution; control group; 3 healthy, 7 ill cats). Cats were placed in a cage containing a small cotton towel that had been sprayed with FFP or vehicle 30 minutes previously. Cats were then videotaped for 125 minutes, and food intake was measured during this period. Videotapes were scored at 5-minute intervals for various behaviors. In study 2, cats were categorized in 1 of 2 groups; group 1 (2 healthy, 8 ill cats) had a cat carrier placed in their cages, and group 2 (5 healthy, 5 ill cats) did not. All cats were exposed to FFP, and 24-hour food intake was measured. Differences between behaviors of healthy versus clinically ill cats were not identified. In the first study, significant increases in grooming and interest in food were found in cats exposed to FFP compared with vehicle. For all cats, significant positive correlations were detected between grooming and facial rubbing, walking and facial rubbing, interest in food and facial rubbing, eating and facial rubbing, grooming and interest in food, and grooming and eating. In the second study, 24-hour food intake was significantly greater in cats exposed to FFP and the cat carrier, compared with cats exposed to FFP alone. Results suggest that exposure to FFP may be useful to increase food intake of hospitalized cats.

ARC-2007-ACD07-0145-018

NASA Image and Video Library

2007-08-01

NASA Officials gather at Ames Research Center to discuss Spaceship development progress. Constellation is developing the Orion spacecraft and Ares rockets to support an American return to the moon by 2020. with John Bluck, NASA Ames PAO officer

ARC-2007-ACD07-0145-014

NASA Image and Video Library

2007-08-01

NASA Officials gather at Ames Research Center to discuss Spaceship development progress. Constellation is developing the Orion spacecraft and Ares rockets to support an American return to the moon by 2020. (with Mike Mewhinney, Ames PAO (news chief) Officer)

75 FR 17920 - Decision To Evaluate a Petition to Designate a Class of Employees for the Ames Laboratory, Ames...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

..., production workers, technicians, salaried graduate students, physical plant workers, administrative and..., Spedding Hall, Research and Chemistry Buildings. Period of Employment: January 1, 1955 through December 31...

Ames Lab 101: Real-Time 3D Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Song

2010-08-02

Ames Laboratory scientist Song Zhang explains his real-time 3-D imaging technology. The technique can be used to create high-resolution, real-time, precise, 3-D images for use in healthcare, security, and entertainment applications.

Ames Lab 101: Real-Time 3D Imaging

ScienceCinema

Zhang, Song

2017-12-22

Ames Laboratory scientist Song Zhang explains his real-time 3-D imaging technology. The technique can be used to create high-resolution, real-time, precise, 3-D images for use in healthcare, security, and entertainment applications.

ARC-2008-ACD08-0260-023

NASA Image and Video Library

2008-11-04

K-10 (red) plaentary rover at Marscape (Ames Mars Yard): with prototype flight control team remotely operating K-10 'Red' from Ames Future Flight Centeral (FFC) Simulator. L-R; Jeff Tripp, David Lees, Trey Smith, Mark Helper, Simon Rutishauser

N-232 Sustainability Base Construction

NASA Image and Video Library

2011-11-10

Construction of the new NASA Ames Green Building dubbed Sustainability Base located on the Ames Research Center campus at Moffett Field, CA. interior view as cubicles are being set up and open spaces arranged. skylights, artifical lighting and windows

N-232 Sustainability Base Construction

NASA Image and Video Library

2011-11-10

Construction of the new NASA Ames Green Building dubbed Sustainability Base located on the Ames Research Center campus at Moffett Field, CA. interior view as cubicles are being set up and open spaces arranged. artifical lighting, skylights and windows

Sensors for Ablative Thermal Protection Systems

NASA Technical Reports Server (NTRS)

Smith, Brandon

2015-01-01

This is a chart for the NASA Ames Instrumentation Workshop scheduled for 16-Sept-2015. The workshop template was used to make the chart. The purpose is to communicate STAR lab capabilities to the larger Ames instrumentation community.

Research and Technology 1999

NASA Technical Reports Server (NTRS)

2000-01-01

This report highlights the challenging work accomplished during fiscal year 1999 by Ames research scientists, engineers, and technologists. It discusses research and technologies that enable the Information Age, that expand the frontiers of knowledge for aeronautics and space, and that help to maintain U.S. leadership in aeronautics and space research and technology development. The accomplishments are grouped into four categories based on NASA's four Strategic Enterprises: Aero-Space Technology, Space, Human Exploration and Development of Space, and Earth Science. The primary purpose of this report is to communicate knowledge-to inform our stakeholders, customers, and partners, and the people of the United States about the scope and diversity of Ames' mission, the nature of Ames' research and technology activities, and the stimulating challenges ahead. The accomplishments cited illustrate the contributions that Ames is making to improve the quality of life for our citizens and the economic position of the United States in the world marketplace.

Optimization of the Ames/salmonella mutagenicity assay for use with extracts of aquatic sediments

USGS Publications Warehouse

Papoulias, Diana M.; Buckler, Denny R.; Tillitt, Donald E.

1996-01-01

Non-mutagenic components interfered with the ability of the standard Ames/salmonella assay to detect mutagenicity in extracts of contaminated Great Lakes sediments. The use of gel permeation chromatography (GPC) to remove these macromolecules from methylene chloride extracts prior to Ames testing enhanced the likelihood of transfer of mutagenic components into dimethyl sulf oxide (the assay solvent). Therefore, to optimize the assay's sensitivity we pre-treated sediment extracts using GPC and increased metabolic activity through the use of a 30% S9 mix. Increasing the level of Aroclor 1254-induced rat liver S9, typically used to metabolically activate promutagens, had the additional beneficial effect of reducing the cytotoxicity of the extracts. As applied in this study, the Ames assay can serve as a sensitive test for screening the mutagenic potential of large numbers of uncharacterized sediment extracts.

Reinventing the ames test as a quantitative lab that connects classical and molecular genetics.

PubMed

Goodson-Gregg, Nathan; De Stasio, Elizabeth A

2009-01-01

While many institutions use a version of the Ames test in the undergraduate genetics laboratory, students typically are not exposed to techniques or procedures beyond qualitative analysis of phenotypic reversion, thereby seriously limiting the scope of learning. We have extended the Ames test to include both quantitative analysis of reversion frequency and molecular analysis of revertant gene sequences. By giving students a role in designing their quantitative methods and analyses, students practice and apply quantitative skills. To help students connect classical and molecular genetic concepts and techniques, we report here procedures for characterizing the molecular lesions that confer a revertant phenotype. We suggest undertaking reversion of both missense and frameshift mutants to allow a more sophisticated molecular genetic analysis. These modifications and additions broaden the educational content of the traditional Ames test teaching laboratory, while simultaneously enhancing students' skills in experimental design, quantitative analysis, and data interpretation.

Study of optical techniques for the Ames unitary wind tunnels. Part 3: Angle of attack

NASA Technical Reports Server (NTRS)

Lee, George

1992-01-01

A review of optical sensors that are capable of accurate angle of attack measurements in wind tunnels was conducted. These include sensors being used or being developed at NASA Ames and Langley Research Centers, Boeing Airplane Company, McDonald Aircraft Company, Arnold Engineering Development Center, National Aerospace Laboratory of the Netherlands, National Research Council of Canada, and the Royal Aircraft Establishment of England. Some commercial sensors that may be applicable to accurate angle measurements were also reviewed. It was found that the optical sensor systems were based on interferometers, polarized light detector, linear or area photodiode cameras, position sensing photodetectors, and laser scanners. Several of the optical sensors can meet the requirements of the Ames Unitary Plan Wind Tunnel. Two of these, the Boeing interferometer and the Complere lateral effect photodiode sensors are being developed for the Ames Unitary Plan Wind Tunnel.

Research and Technology 1998

NASA Technical Reports Server (NTRS)

1999-01-01

This report highlights the challenging work accomplished during fiscal year 1998 by Ames research scientists, engineers, and technologists. It discusses research and technologies that enable the Information Age, that expand the frontiers of knowledge for aeronautics and space, and that help to maintain U.S. leadership in aeronautics and space research and technology development. The accomplishments are grouped into four categories based on NASA's four Strategic Enterprises: Aero-Space Technology, Space Science, Human Exploration and Development of Space, and Earth Science. The primary purpose of this report is to communicate knowledge-to inform our stakeholders, customers, and partners, and the people of the United States about the scope and diversity of Ames mission, the nature of Ames research and technology activities, and the stimulating challenges ahead. The accomplishments cited illustrate the contributions that Ames is making to improve the quality of life for our citizens and the economic position of the United States in the world marketplace.

Hebbian based learning with winner-take-all for spiking neural networks

NASA Astrophysics Data System (ADS)

Gupta, Ankur; Long, Lyle

2009-03-01

Learning methods for spiking neural networks are not as well developed as the traditional neural networks that widely use back-propagation training. We propose and implement a Hebbian based learning method with winner-take-all competition for spiking neural networks. This approach is spike time dependent which makes it naturally well suited for a network of spiking neurons. Homeostasis with Hebbian learning is implemented which ensures stability and quicker learning. Homeostasis implies that the net sum of incoming weights associated with a neuron remains the same. Winner-take-all is also implemented for competitive learning between output neurons. We implemented this learning rule on a biologically based vision processing system that we are developing, and use layers of leaky integrate and fire neurons. The network when presented with 4 bars (or Gabor filters) of different orientation learns to recognize the bar orientations (or Gabor filters). After training, each output neuron learns to recognize a bar at specific orientation and responds by firing more vigorously to that bar and less vigorously to others. These neurons are found to have bell shaped tuning curves and are similar to the simple cells experimentally observed by Hubel and Wiesel in the striate cortex of cat and monkey.

Feline immunodeficiency virus testing in stray, feral, and client-owned cats of Ottawa

PubMed Central

2005-01-01

Abstract Feline immunodeficiency virus (FIV) seroprevalence is evaluated in 3 groups of cats. Seventy-four unowned urban strays were tested, as well as 20 cats from a small feral cat colony, and 152 client-owned cats. Of the 246 cats tested, 161 (65%) were male and 85 (35%) were female. Seroprevalence for FIV was 23% in the urban strays, 5% in the feral cat colony, and 5.9% in the client-owned cats. Ten cats (4%) were also positive for Feline leukemia virus (FeLV) antigen, including 2 cats coinfected with FeLV and FIV. Seroprevalence for FIV in cats from Ottawa is similar to that found in other nonrandom studies of cats in North America. PMID:16454381

Feline immunodeficiency virus testing in stray, feral, and client-owned cats of Ottawa.

PubMed

Little, Susan E

2005-10-01

Feline immunodeficiency virus (FIV) seroprevalence is evaluated in 3 groups of cats. Seventy-four unowned urban strays were tested, as well as 20 cats from a small feral cat colony, and 152 client-owned cats. Of the 246 cats tested, 161 (65%) were male and 85 (35%) were female. Seroprevalence for FIV was 23% in the urban strays, 5% in the feral cat colony, and 5.9% in the client-owned cats. Ten cats (4%) were also positive for Feline leukemia virus (FeLV) antigen, including 2 cats coinfected with FeLV and FIV. Seroprevalence for FIV in cats from Ottawa is similar to that found in other nonrandom studies of cats in North America.

Metabolic and hormonal alterations in cats with hepatic lipidosis.

PubMed

Brown, B; Mauldin, G E; Armstrong, J; Moroff, S D; Mauldin, G N

2000-01-01

Hepatic lipidosis in cats is a commonly diagnosed hepatobiliary disease of unknown cause. The purpose of this prospective study was to characterize the blood hormone and lipid status of cats with hepatic lipidosis, and to compare this status to that of cats with other types of liver disease and to control cats. Twenty-three cats with hepatic disease were assigned to 1 of 2 groups on the basis of cytopathologic or histopathologic examination of the liver: group 1, hepatic lipidosis (n = 18); or group 2, cholangiohepatitis (n = 5). Ten healthy young adult cats were used as controls. Food was withheld from control animals for 24 hours before blood collection. Concentrations of plasma glucagon and serum insulin, cortisol, thyroxine, triglycerides, cholesterol, phospholipids, and nonesterified fatty acids (NEFAs) were determined in all cats, in addition to routine hematologic and serum biochemical testing. Cats with hepatic lipidosis had higher serum NEFA concentrations than cats with cholangiohepatitis or control cats (P < .05). Cats with cholangiohepatitis had higher serum cholesterol and phospholipid concentrations than those of cats with lipidosis or control cats (P < .05); their plasma glucagon concentrations were higher than those of control cats (P < .05), but were not different from those of cats with hepatic lipidosis. Serum insulin concentrations were significantly higher in control cats than in diseased cats (P < .05), but neither serum insulin nor the insulin to glucagon ratio was significantly different among the cats with hepatic disease. The high concentration of NEFAs in cats with hepatic lipidosis suggests that at least 1 factor in the pathogenesis of this syndrome may involve the regulation of hormone-sensitive lipase.

Seroprevalence of Coxiella burnetii in domesticated and feral cats in eastern Australia.

PubMed

Shapiro, Amanda J; Bosward, Katrina L; Heller, Jane; Norris, Jacqueline M

2015-05-15

The seroprevalence of Coxiella burnetii (C. burnetii) in cats in eastern Australia is unknown, and the risk of transmission from cats to humans is undetermined. This study aimed to determine the exposure of cats to C. burnetii in four distinct cat subpopulations. An indirect immunofluoresence assay (IFA) and an Enzyme-linked immunosorbent assay (ELISA) used for detection of anti-C. burnetii antibodies in humans were adapted, verified for use on feline serum, and compared. Cat serum samples (n=712) were tested with IFA from four subpopulations [cattery-confined breeding cats, pet cats, feral cats and shelter cats]. The proportions of seropositive cats were; cattery-confined breeding cats (35/376, 9.3%), pets (2/198, 1%), feral cats (0/50), shelter cats (0/88). The significant variables in C. burnetii seropositivity were cattery-confined breeding cat subpopulation and sterilisation status, with infected cats 17.1 (CI 4.2-70.2; P<0.001) times more likely to be cattery-confined breeding cats and 6.00 (CI 2.13-16.89; P<0.001) times more likely to be entire than sterilised. ELISA was used on 143 of 712 sera tested with IFA, and the Cohen's Kappa coefficient of 0.75 indicated 92.2% agreement between the two assays. These results confirm that Australian cats have been exposed to C. burnetii and that a higher seroprevalence of C. burnetii is seen amongst cattery-confined breeding cats. Cat breeders and veterinary personnel involved in feline reproductive procedures may be at higher risk of exposure to C. burnetii. Copyright © 2015 Elsevier B.V. All rights reserved.

Evaluation of inciting causes, alternative targets, and risk factors associated with redirected aggression in cats.

PubMed

Amat, Marta; Manteca, Xavier; Brech, Susana Le; Ruiz de la Torre, José Luís; Mariotti, Valentina M; Fatjó, Jaume

2008-08-15

To identify inciting causes, alternative targets, and risk factors associated with redirected aggression in cats. Case-control study. 19 cats with a history of redirected aggression and 64 cats with no such history. Medical records were reviewed to identify cats evaluated for problems with redirected aggression (case cats), in which the primary inciting stimulus and alternative target of aggression were clearly identifiable. Data obtained from the records and from follow-up interviews included details about the cats and incidents of redirected aggression. Owners of control cats were interviewed via telephone to obtain similar information on their cats. 22 incidents of redirected aggression were reported for the 19 case cats. In 95% of those incidents, loud noises or interactions with other cats were identified as the inciting stimuli. Case cats most commonly redirected their aggression toward the owner, followed by another cat living in the same household. Compared with control cats, case cats were more likely to have a sound phobia but were less likely to be outdoor cats. In addition, case cats were more likely to be from small households (

Reconciling actual and perceived rates of predation by domestic cats

PubMed Central

McDonald, Jennifer L; Maclean, Mairead; Evans, Matthew R; Hodgson, Dave J

2015-01-01

The predation of wildlife by domestic cats (Felis catus) is a complex problem: Cats are popular companion animals in modern society but are also acknowledged predators of birds, herpetofauna, invertebrates, and small mammals. A comprehensive understanding of this conservation issue demands an understanding of both the ecological consequence of owning a domestic cat and the attitudes of cat owners. Here, we determine whether cat owners are aware of the predatory behavior of their cats, using data collected from 86 cats in two UK villages. We examine whether the amount of prey their cat returns influences the attitudes of 45 cat owners toward the broader issue of domestic cat predation. We also contribute to the wider understanding of physiological, spatial, and behavioral drivers of prey returns among cats. We find an association between actual prey returns and owner predictions at the coarse scale of predatory/nonpredatory behavior, but no correlation between the observed and predicted prey-return rates among predatory cats. Cat owners generally disagreed with the statement that cats are harmful to wildlife, and disfavored all mitigation options apart from neutering. These attitudes were uncorrelated with the predatory behavior of their cats. Cat owners failed to perceive the magnitude of their cats’ impacts on wildlife and were not influenced by ecological information. Management options for the mitigation of cat predation appear unlikely to work if they focus on “predation awareness” campaigns or restrictions of cat freedom. PMID:26306163

Study of relapse and failure cases of CAT I retreated with CAT II under RNTCP--an eleven year follow up.

PubMed

Mehra, R K; Dhingra, V K; Nish, Aggarwal; Vashist, R P

2008-10-01

To analyse the treatment outcome of Cat I smear positive relapse and failure cases and their fate when treated with Cat II regimen under RNTCP. All Cat I smear positive relapse and failure TB patients treated with Category II regimen from 1994 to 2005 in a chest clinic of Delhi were analysed in this retrospective study. The re-treatment outcome data for relapse and failure cases of Cat I when treated with Cat II regimen was reviewed. The study population included 5576 registered as Cat I sputum positive cases in Gulabi Bagh chest clinic from 1994 to 2005. A total of 190 (3.4%) failed on Cat I regimen. Further out of 4905 (87.9%) successfully treated Cat I patients, 442 (9%) presented as relapses. The treatment success rate for relapse and failure cases of Cat I when subsequently treated with Cat II regimen were 76.4% and 48.8% respectively, with a significantly higher failure rate (27.6%) among Cat I failures subsequently treated with Cat II regimen. The failure cases of Cat I subsequently treated with Cat II were observed to have a significantly lower success rates (p < 0.05) as compared to relapse cases. The need for reappraisal of Cat II re-treatment regimen for failure cases among Cat I is suggested.

Are cats (Felis catus) from multi-cat households more stressed? Evidence from assessment of fecal glucocorticoid metabolite analysis.

PubMed

Ramos, D; Reche-Junior, A; Fragoso, P L; Palme, R; Yanasse, N K; Gouvêa, V R; Beck, A; Mills, D S

2013-10-02

Given the social and territorial features described in feral cats, it is commonly assumed that life in multi-cat households is stressful for domestic cats and suggested that cats kept as single pets are likely to have better welfare. On the other hand, it has been hypothesized that under high densities cats can organize themselves socially thus preventing stress when spatial dispersion is unavailable. This study was aimed at comparing the general arousal underpinning emotional distress in single housed cats and in cats from multi-cat households (2 and 3-4 cats) on the basis of fecal glucocorticoid metabolites (GCM) measured via enzyme immunoassay (EIA). GCM did not significantly vary as a function of living style (single, double or group-housing); highly stressed individuals were equally likely in the three groups. Young cats in multi-cat households had lower GCM, and overall cats that tolerate (as opposed to dislike) petting by the owners tended to have higher GCM levels. Other environmental aspects within cat houses (e.g. relationship with humans, resource availability) may play a more important role in day to day feline arousal levels than the number of cats per se. © 2013.

Vasa Vasorum Arteriopathy: Relationship With Systemic Arterial Hypertension and Other Vascular Lesions in Cats.

PubMed

Kohnken, R; Scansen, B A; Premanandan, C

2017-05-01

The vasa vasorum is a delicate network of small arterioles that supplies nutrients to the adventitia and outer media of large arteries. In humans, dysfunction of the vasa vasorum contributes to the pathogenesis of aortic dissection and atherosclerosis. Twenty-four cats from 1 to 18 years of age were prospectively evaluated. Cases were divided into 3 cohorts-with systemic hypertension, without systemic hypertension, and uncertain. Histologic sections of the aorta and main pulmonary artery, as well as sections of kidney and lung, were blindly examined by 2 pathologists. The severity of vasa vasorum arteriopathy was compared to the presence of renal arteriosclerosis, aortic medial degeneration, subintimal fibroplasia of the main pulmonary artery, and blood pressure. We found that vasa vasorum arteriopathy correlated strongly with hypertensive status, degree of renal arteriosclerosis, and lesions in the great vessels. The positive predictive value of a severe vasa vasorum score for systemic hypertension was 84.6%. Lesions of vasa vasorum arteriopathy were predictive of renal arteriosclerosis with 100% sensitivity and 64.7% specificity. The positive predictive value of a severe vasa vasorum score for the presence of aortic lesions was 69.2% vs 91.6% for lesions in the main pulmonary artery. The vasa vasorum appears to be an important responder to systemic hypertension in cats, and arteriopathy of this vascular bed has significant implications for the integrity of the great vessels.

Limbic control of aggression in the cat.

PubMed

Adamec, R E; Stark-Adamec, C I

1983-01-01

Over a decade of work by Flynn and colleagues has delineated a network of limbic circuits which function to modulate the expression of predatory aggression and defence in the cat, and aspects of this work are reviewed. In particular, Flynn's work revealed a circuit involving the basomedial amygdala which functions to suppress attack, and at the same time facilitates defence. A second circuit, involving the ventral hippocampus, is involved in attack facilitation. Studies relating stable differences in excitability in these two circuits to developmentally determined behavioural dispositions toward aggression or defence are summarized. Finally, the impact of experimentally induced limbic seizures on interictally maintained expression of aggression and defence behaviourally, and on limbic excitability are reviewed. Taken together, the data indicate that the behavioural balance of attack and defence is under the tonic control of opponent limbic circuits, which are themselves biased in a measureable manner. Developmental studies indicate that adult defensiveness is determined early in life, so early as to suggest some pre-programmed neuro-developmental process. Experimentally induced seizures alter behaviour lastingly, producing an increase in defensive disposition. At the same time there is an equally lasting potentiation of interictal transmission of neural activity from the amygdala to the hypothalamus. Moreover, seizures may reduce interictal transmission of activity through the ventral hippocampus by potentiating recurrent inhibition. These effects of seizures are of interest since seizures reproduce naturally occurring differences in limbic excitability seen in naturally defensive cats.

A cross-sectional study of Tritrichomonas foetus infection in feral and shelter cats in Prince Edward Island, Canada.

PubMed

Raab, Oriana; Greenwood, Spencer; Vanderstichel, Raphael; Gelens, Hans

2016-03-01

A cross-sectional study examined the occurrence of Tritrichomonas foetus, and other intestinal parasites, in feral and shelter cats in Prince Edward Island (PEI). Fecal samples were collected from 100 feral cats, 100 cats from the PEI Humane Society, and 5 cats from a private residence. The occurrence of T. foetus, based on fecal culture, was 0% in feral and shelter cats. A single positive sample was obtained from an owned Abyssinian cat that was imported to PEI. Intestinal parasites were identified via fecal flotation in 76% of feral cats and 39% of cats from the humane society. Feral cats had a higher incidence of Toxocara cati than cats from the humane society (P < 0.001), conversely, shelter cats had a higher incidence of Cystoisospora spp. (P < 0.001). These results suggest that while T. foetus is not of importance in feral and shelter cats in PEI, imported cats could serve as reservoirs.

A cross-sectional study of Tritrichomonas foetus infection in feral and shelter cats in Prince Edward Island, Canada

PubMed Central

Raab, Oriana; Greenwood, Spencer; Vanderstichel, Raphael; Gelens, Hans

2016-01-01

A cross-sectional study examined the occurrence of Tritrichomonas foetus, and other intestinal parasites, in feral and shelter cats in Prince Edward Island (PEI). Fecal samples were collected from 100 feral cats, 100 cats from the PEI Humane Society, and 5 cats from a private residence. The occurrence of T. foetus, based on fecal culture, was 0% in feral and shelter cats. A single positive sample was obtained from an owned Abyssinian cat that was imported to PEI. Intestinal parasites were identified via fecal flotation in 76% of feral cats and 39% of cats from the humane society. Feral cats had a higher incidence of Toxocara cati than cats from the humane society (P < 0.001), conversely, shelter cats had a higher incidence of Cystoisospora spp. (P < 0.001). These results suggest that while T. foetus is not of importance in feral and shelter cats in PEI, imported cats could serve as reservoirs. PMID:26933262

Seroprevalence of Toxoplasma gondii antibodies in cats from Durango City, Mexico.

PubMed

Alvarado-Esquivel, C; Liesenfeld, O; Herrera-Flores, R G; Ramírez-Sánchez, B E; González-Herrera, A; Martínez-García, S A; Dubey, J P

2007-10-01

The prevalence of antibodies to Toxoplasma gondii was determined in sera from 105 domestic cats from Durango City, Mexico. Using a modified agglutination test, antibodies to this parasite were found in 21% of the 105 cats, with titers of 1:25 in 3 cats, 1:50 in 4 cats, 1:200 in 5 cats, 1:400 in 2 cats, 1:800 in 2 cats, 1:1,600 in 4 cats, and 1:3,200 or higher in 2 cats. Cats older than 1 yr had a significantly higher frequency of infection than that found in cats younger than 0.5 yr (41 vs. 13.2%, respectively; odds ratio = 4.55; 95% CI = 1.24-17.18; P = 0.01). Overall, the seroprevalence of T. gondii antibodies in cats in Durango, Mexico, is much lower compared with those reported in other countries.

ARC-2007-ACD07-0145-024

NASA Image and Video Library

2007-08-01

NASA Officials gather at Ames Research Center to discuss Spaceship development progress. Constellation is developing the Orion spacecraft and Ares rockets to support an American return to the moon by 2020. Bill Moede and Jim Taylor, Ames (Planners) Video crew

ARC-2011-ACD11-0206-036

NASA Image and Video Library

2011-12-01

Neil DeGrasse Tyson, Astrophysicist with Hayden Planetarium, the American Museum of Natural History, visits the Ames Kepler Science Team during the 1000 days since Launch Review. at reception speaking with Dr. David Morrison, Ames Serior Scientist, NASA Astrobiology, on right.

ARC-1958-A-23753

NASA Image and Video Library

1958-01-30

Shadowgraph of Finned Hemispherical model in free-flight show shock waves produced by blunt bodies (H. Julian Allen blunt nose theory) (Used in NASA/AMES publication 'Adventures in Research' A history of Ames Research Center 1940 - 1965 by Edwin P. Hartman - SP-4302)

1. Photocopy of photograph (original print located in Pope & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of photograph (original print located in Pope & Talbot Archives. Port Gamble, WA.) Unknown Photographer, Unknown Date. View of Walker-Ames House, house no. 1, facing southwest. - Walker-Ames House, Rainier Avenue, Port Gamble, Kitsap County, WA

ARC-2006-ACD06-0050-055

NASA Image and Video Library

2006-03-14

Space Shuttle 3% scale model to analyze removal of PAL ramp and other effects in the 11 ft. w.t. from left to right Rabi Meha, Ames AO, Grey Potts, Boeing, Bill Van Zuylen, Ames AO, Chris Radbourne and Rob Kornienko

ARC-1986-AC86-0746-2

NASA Image and Video Library

1986-10-10

Ames Director William 'Bill' Ballhaus (center left) joins visitor Sir Jeffrey Pope from Royla Aircraft Industry, England (center right) at the NAS Facility Cray 2 computer with Ron Deiss, NAS Deputy Manager (L) and Vic Peterson, Ames Deputy Director (R).

ARC-2008-ACD08-0260-016

NASA Image and Video Library

2008-11-04

K-10 (red) plaentary rover at Marscape (Ames Mars Yard): with prototype flight control team remotely operating K-10 'Red' from Ames Future Flight Centeral (FFC) Simulator, L-R Eric Park, Debra Schreckenghost, Rob Landis, Tod Milam, Steve Riley, Estrellina Pacis

Ames Lab 101: C6: Virtual Engineering

ScienceCinema

McCorkle, Doug

2018-01-01

Ames Laboratory scientist Doug McCorkle explains the importance of virtual engineering and talks about the C6. The C6 is a three-dimensional, fully-immersive synthetic environment residing in the center atrium of Iowa State University's Howe Hall.

ARC-2009-ACD09-0186-049

NASA Image and Video Library

2009-08-25

Sustainability Base Ground Breaking ceremony with Steve Zornetzer, Associate Director Ames Research Center, Lt. Governor John Garamendi of California, Jane Grant, Architect AECOM, Pete Worden, Director Ames Research Center, Kenvin Burke, Swinerton Builders Rep. ready to turn the first shovel.

ARC-2009-ACD09-0186-047

NASA Image and Video Library

2009-08-25

Sustainability Base Ground Breaking ceremony with Steve Zornetzer, Associate Director Ames Research Center, Lt. Governor John Garamendi of California, Jane Grant, Architect AECOM, Pete Worden, Director Ames Research Center, Kenvin Burke, Swinerton Builders Rep. ready to turn the first shovel.

ARC-2009-ACD09-0186-044

NASA Image and Video Library

2009-08-25

Sustainability Base Ground Breaking ceremony with Steve Zornetzer, Associate Director Ames Research Center, Lt. Governor John Garamendi of California, Kenvin Burke, Jane Grant, Architect AECOM, Pete Worden, Director Ames Research Center, Swinerton Builders Rep. ready to turn the first shovel.

ARC-2009-ACD09-0186-046

NASA Image and Video Library

2009-08-25

Sustainability Base Ground Breaking ceremony with Steve Zornetzer, Associate Director Ames Research Center, Lt. Governor John Garamendi of California, Jane Grant, Architect AECOM, Pete Worden, Director Ames Research Center, Kenvin Burke, Swinerton Builders Rep. ready to turn the first shovel.

ARC-2009-ACD09-0186-048

NASA Image and Video Library

2009-08-25

Sustainability Base Ground Breaking ceremony with Steve Zornetzer, Associate Director Ames Research Center, Lt. Governor John Garamendi of California, Jane Grant, Architect AECOM, Pete Worden, Director Ames Research Center, Kenvin Burke, Swinerton Builders Rep. ready to turn the first shovel.

Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

NASA Image and Video Library

2017-02-15

Ashley Karp, NASA JPL (Left) and Hunjoo Kim, NASA JPL (Right) attaching heat sensors the Peregrine Hybrid Rocket Engine prior to its test at the Outdoor Aerodynamic Research Facility (OARF, N-249) at NASA's Ames Research Center.

Ames Research Center Publications, July 1971 through December 1973

NASA Technical Reports Server (NTRS)

1975-01-01

A bibliography of the publications of Ames Research Center authors and contractors which appeared as formal NASA publications, journal articles, books, chapters of books, patents, and contractor reports is presented. Years covered are July 1971 through December 1973.

ARC-2011-ACD11-0021-029

NASA Image and Video Library

2011-02-11

NASA Ames Tweetup and tour of center by invitation of the NASA Ames Public Affairs Office. Tweeter group visit the Kepler Science Ops Center (SOC), while there recieve a overview and participate in a Q & A from Jeff Van Cleve.

ARC-2009-ACD09-0068-038

NASA Image and Video Library

2009-04-22

Tour DE Ames Bicycle event (start at Macon Road Gate - ending a the Old Mimi Mart on R.T. Jones Road) Deb Feng, Chief Center Operations (acting), starts off the race with fellow bikers on the first Tour de Ames

Apparent metabolizable and net energy values of corn and soybean meal for broiler breeding cocks.

PubMed

Liu, W; Liu, G H; Liao, R B; Chang, Y L; Huang, X Y; Wu, Y B; Yang, H M; Yan, H J; Cai, H Y

2017-01-01

The AME and net energy (NE) values of 4 corn varieties, including 2 normal corn varieties (Zheng Dan 958 and Xian Yu 335), and one each of waxy corn and sweet corn, and 2 soybean meal samples including regular (RSBM) and dehulled soybean meal (DSBM), were determined in 2 experiments for broiler breeding cocks using the indirect calorimetry method. The 4 test diets in Experiment 1 consisted of each test corn, which replaced 40% of the corn-soybean meal basal diet, and the test diets in Experiment 2 contained 25% RSBM or DSBM, which was used to replace the corn basal diet. Thirty (Experiment 1) or 18 (Experiment 2) 50-week-old Arbor Acre (AA) broiler breeding cocks were used in a completely randomized design. After a 7 d dietary adaptation period, 6 birds as replicates from each treatment were assigned to individual respiration chambers for energy measurement via gaseous exchange and total excreta collection for 10 d. In Experiment 1, the AME, ME intake (MEI), retained energy (RE), NE, and NE:AME ratio values were higher (P < 0.001) in the test diets as compared with the corn-soybean meal basal diet. The AME and NE values in the sweet corn diet were higher (P < 0.05) than those values in the other 3 test diets. The heat production (HP), fasting heat production (FHP), and respiration quotient (RQ) were not influenced by the various experimental diets. The respective AME and NE values were 3,785, 3,775, 3,738, and 3,997 kcal/kg (DM basis), and 2,982, 3,006, 2,959, and 3,146 kcal/kg (DM basis) for Zheng Dan 958, Xian Yu 335, waxy corn, and sweet corn. Birds fed a corn basal diet in Experiment 2 had higher AME, MEI, RE, NE, and NE:AME ratio values (P < 0.001). Soybean meal substitution had no effect on HP, FHP, or RQ. The average AME and NE content was 2,492 and 1,581 kcal/kg (DM basis) for RSBM, and 2,580 and 1,654 kcal/kg (DM basis) for DSBM, respectively. © 2016 Poultry Science Association Inc.

Association between characteristics of cats and satisfaction of owners who adopted cats from an animal hospital in Japan.

PubMed

Onodera, Nodoka; Uchida, Keiko; Kakuma, Yoshie

2014-05-01

A follow-up questionnaire survey was conducted with 29 cat owners who adopted cats from an animal hospital in Japan. Physical characteristics were found to be important factors for the owners when choosing a cat. There were significant differences between impression of the cat for the owners at present and images of their ideal cats, and the levels of aggression and activeness of the cats at present were rated higher than their ideal cats. A significant negative correlation was found between the degree of satisfaction with the cat and occurrence of house soiling; thus, some behavioral problems may deteriorate the relationship between the owner and the cat.

Conformational Changes in Orotidine 5-Monophosphate Decarboxylase: "Remote" Residues That Stabilize the Active Conformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wood, B.; Amyes, T; Fedorov, A

2010-01-01

The structural factors responsible for the extraordinary rate enhancement ({approx}10{sup 17}) of the reaction catalyzed by orotidine 5{prime}-monophosphate decarboxylase (OMPDC) have not been defined. Catalysis requires a conformational change that closes an active site loop and 'clamps' the orotate base proximal to hydrogen-bonded networks that destabilize the substrate and stabilize the intermediate. In the OMPDC from Methanobacter thermoautotrophicus, a 'remote' structurally conserved cluster of hydrophobic residues that includes Val 182 in the active site loop is assembled in the closed, catalytically active conformation. Substitution of these residues with Ala decreases k{sub cat}/K{sub m} with a minimal effect on k{sub cat},more » providing evidence that the cluster stabilizes the closed conformation. The intrinsic binding energies of the 5{prime}-phosphate group of orotidine 5{prime}-monophosphate for the mutant enzymes are similar to that for the wild type, supporting this conclusion.« less

Expression of cathepsin S antisense transcripts by adenovirus in retinal pigment epithelial cells.

PubMed

Rakoczy, P E; Lai, M C; Baines, M G; Spilsbury, K; Constable, I J

1998-10-01

To show the production of sense or antisense transcripts by recombinant adenoviruses, to investigate whether the transcripts produced were suitable for downregulating the expression of the targeted gene, cathepsin S (CatS), and to examine the effect of antisense transcript production on the biologic function of retinal pigment epithelial (RPE) cells, including the regulation of endogenous aspartic protease expression. Ad.MLP.CatSAS, Ad.RSV.CatSAS, and Ad.MLP.CatSS recombinant viruses were produced by homologous recombination. The recombinant viruses were tested by restriction enzyme digestion to confirm the orientation of the inserts. The expression of antisense transcripts was tested by northern blot analysis. Western blot analysis was used to study the regulation of the endogenous CatS protein in ARPE19 cells. The biologic effect of CatS downregulation in ARPE19 cells was tested by proliferation and phagocytosis assays, de novo cathepsin D (CatD) synthesis, and measurement of aspartic protease activity. After characterization of the recombinant adenovirus constructs, the production of antisense and sense CatS transcripts was shown in ARPE19 cells. The transcripts appeared at approximately 1.9 kb 48 hours after transduction, and the expression of the antisense transcripts was similar in constructs carrying either the MLP or the RSV promoter. Western blot analysis showed that ARPE19 cells transduced with Ad.MLP.CatSAS and Ad.RSV.CatSAS had no detectable CatS. In contrast, there was a strong signal appearing at 24 kDa in ARPE19 cells transduced with Ad.MLP.CatSS. ARPE19 cells were transduced to a high level. The transduction of ARPE19 cells with the recombinant adenoviruses did not affect the morphologic appearance of the cells, their proliferation, or their phagocytosing ability. However, ARPE19 cells transduced by Ad.MLP.CatSAS recombinant adenovirus showed a significant downregulation of de novo CatD synthesis and a twofold decrease in aspartic protease activity. Recombinant adenoviruses were shown to be suitable for producing antisense CatS transcripts to modulate endogenous CatS expression in RPE cells. It is proposed that CatS may play an important role, directly or indirectly, in the lysosomal digestion of outer segments through the regulation of other lysosomal enzyme activity, such as the expression of CatD.

Generative models for network neuroscience: prospects and promise

PubMed Central

Betzel, Richard F.

2017-01-01

Network neuroscience is the emerging discipline concerned with investigating the complex patterns of interconnections found in neural systems, and identifying principles with which to understand them. Within this discipline, one particularly powerful approach is network generative modelling, in which wiring rules are algorithmically implemented to produce synthetic network architectures with the same properties as observed in empirical network data. Successful models can highlight the principles by which a network is organized and potentially uncover the mechanisms by which it grows and develops. Here, we review the prospects and promise of generative models for network neuroscience. We begin with a primer on network generative models, with a discussion of compressibility and predictability, and utility in intuiting mechanisms, followed by a short history on their use in network science, broadly. We then discuss generative models in practice and application, paying particular attention to the critical need for cross-validation. Next, we review generative models of biological neural networks, both at the cellular and large-scale level, and across a variety of species including Caenorhabditis elegans, Drosophila, mouse, rat, cat, macaque and human. We offer a careful treatment of a few relevant distinctions, including differences between generative models and null models, sufficiency and redundancy, inferring and claiming mechanism, and functional and structural connectivity. We close with a discussion of future directions, outlining exciting frontiers both in empirical data collection efforts as well as in method and theory development that, together, further the utility of the generative network modelling approach for network neuroscience. PMID:29187640

Corrosion Program

DTIC Science & Technology

2010-02-01

April 2010 8-10 June 2010 3-5 August 2010 5 Corrosion Assistance Team ( CAT ) Visits Classroom Briefing • General Corrosion Theory • Preventive Maintenance...MD DC CAT Visit 2009 CAT Visit 2008 CAT Visit 2007 CAT Visit 2006 CAT Visit 2005 CAT Visits (calendar year) ME HI Germany ROK Honduras Egypt Japan DE 8

Differences between vocalization evoked by social stimuli in feral cats and house cats.

PubMed

Yeon, Seong C; Kim, Young K; Park, Se J; Lee, Scott S; Lee, Seung Y; Suh, Euy H; Houpt, Katherine A; Chang, Hong H; Lee, Hee C; Yang, Byung G; Lee, Hyo J

2011-06-01

To investigate how socialization can affect the types and characteristics of vocalization produced by cats, feral cats (n=25) and house cats (n=13) were used as subjects, allowing a comparison between cats socialized to people and non-socialized cats. To record vocalization and assess the cats' responses to behavioural stimuli, five test situations were used: approach by a familiar caretaker, by a threatening stranger, by a large doll, by a stranger with a dog and by a stranger with a cat. Feral cats showed extremely aggressive and defensive behaviour in most test situations, and produced higher call rates than those of house cats in the test situations, which could be attributed to less socialization to other animals and to more sensitivity to fearful situations. Differences were observed in the acoustic parameters of feral cats in comparison to those of house cats. The feral cat produced significantly higher frequency in fundamental frequency, peak frequency, 1st quartile frequency, 3rd quartile frequency of growls and hisses in agonistic test situations. In contrast to the growls and hisses, in meow, all acoustic parameters like fundamental frequency, first formant, peak frequency, 1st quartile frequency, and 3rd quartile frequency of house cats were of significantly higher frequency than those of feral cats. Also, house cats produced calls of significantly shorter in duration than feral cats in agonistic test situations. These results support the conclusion that a lack of socialization may affect usage of types of vocalizations, and the vocal characteristics, so that the proper socialization of cat may be essential to be a suitable companion house cat. Copyright © 2011 Elsevier B.V. All rights reserved.

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications

PubMed Central

Kumar VR, Santhosh; Darisipudi, Murthy N.; Steiger, Stefanie; Devarapu, Satish Kumar; Tato, Maia; Kukarni, Onkar P.; Mulay, Shrikant R.; Thomasova, Dana; Popper, Bastian; Demleitner, Jana; Zuchtriegel, Gabriele; Reichel, Christoph; Cohen, Clemens D.; Lindenmeyer, Maja T.; Liapis, Helen; Moll, Solange; Reid, Emma; Stitt, Alan W.; Schott, Brigitte; Gruner, Sabine; Haap, Wolfgang; Ebeling, Martin; Hartmann, Guido

2016-01-01

Endothelial dysfunction is a central pathomechanism in diabetes-associated complications. We hypothesized a pathogenic role in this dysfunction of cathepsin S (Cat-S), a cysteine protease that degrades elastic fibers and activates the protease-activated receptor-2 (PAR2) on endothelial cells. We found that injection of mice with recombinant Cat-S induced albuminuria and glomerular endothelial cell injury in a PAR2-dependent manner. In vivo microscopy confirmed a role for intrinsic Cat-S/PAR2 in ischemia–induced microvascular permeability. In vitro transcriptome analysis and experiments using siRNA or specific Cat-S and PAR2 antagonists revealed that Cat-S specifically impaired the integrity and barrier function of glomerular endothelial cells selectively through PAR2. In human and mouse type 2 diabetic nephropathy, only CD68+ intrarenal monocytes expressed Cat-S mRNA, whereas Cat-S protein was present along endothelial cells and inside proximal tubular epithelial cells also. In contrast, the cysteine protease inhibitor cystatin C was expressed only in tubules. Delayed treatment of type 2 diabetic db/db mice with Cat-S or PAR2 inhibitors attenuated albuminuria and glomerulosclerosis (indicators of diabetic nephropathy) and attenuated albumin leakage into the retina and other structural markers of diabetic retinopathy. These data identify Cat-S as a monocyte/macrophage–derived circulating PAR2 agonist and mediator of endothelial dysfunction–related microvascular diabetes complications. Thus, Cat-S or PAR2 inhibition might be a novel strategy to prevent microvascular disease in diabetes and other diseases. PMID:26567242

Seroprevalences of antibodies against Bartonella henselae and Toxoplasma gondii and fecal shedding of Cryptosporidium spp, Giardia spp, and Toxocara cati in feral and pet domestic cats.

PubMed

Nutter, Felicia B; Dubey, J P; Levine, Jay F; Breitschwerdt, Edward B; Ford, Richard B; Stoskopf, Michael K

2004-11-01

To compare seroprevalences of antibodies against Bartonella henselae and Toxoplasma gondii and fecal shedding of Cryptosporidium spp, Giardia spp, and Toxocara cati in feral and pet domestic cats. Prospective cross-sectional serologic and coprologic survey. 100 feral cats and 76 pet domestic cats from Randolph County, NC. Blood and fecal samples were collected and tested. Percentages of feral cats seropositive for antibodies against B. henselae and T. gondii (93% and 63%, respectively) were significantly higher than percentages of pet cats (75% and 34%). Percentages of feral and pet cats with Cryptosporidium spp (7% of feral cats; 6% of pet cats), Giardia spp (6% of feral cats; 5% of pet cats), and T. cati ova (21% of feral cats; 18% of pet cats) in their feces were not significantly different between populations. Results of CBCs and serum biochemical analyses were not significantly different between feral and pet cats, except that feral cats had a significantly lower median PCV and significantly higher median neutrophil count. Results suggested that feral and pet cats had similar baseline health status, as reflected by results of hematologic and serum biochemical testing and similar prevalences of infection with Cryptosporidium spp, Giardia spp, and T. cati. Feral cats did have higher seroprevalences of antibodies against B. henselae and T. gondii than did pet cats, but this likely was related to greater exposure to vectors of these organisms.

2005 Tri-Service Infrastructure Systems Conference and Exhibition. Volume 2, Track 2

DTIC Science & Technology

2005-08-04

not produce toxic by-products, including: – UV – E-Beam – Pulsed Corona Discharge R&D Simulation of Fate & Transport of a CB Agent in a Water...Nationwide network of sensors with integration with ASOCC or CATS . – CHPPM - Soldier health, sensors, and fate of agent. – Congressional line-item with Hach...west Nile virus ), birds (avian flu) Public meeting Aug 10. Construction start ~ late Aug – early Sep pending signed MOA P & S complete, some

Association between Characteristics of Cats and Satisfaction of Owners who Adopted Cats from an Animal Hospital in Japan

PubMed Central

ONODERA, Nodoka; UCHIDA, Keiko; KAKUMA, Yoshie

2014-01-01

ABSTRACT A follow-up questionnaire survey was conducted with 29 cat owners who adopted cats from an animal hospital in Japan. Physical characteristics were found to be important factors for the owners when choosing a cat. There were significant differences between impression of the cat for the owners at present and images of their ideal cats, and the levels of aggression and activeness of the cats at present were rated higher than their ideal cats. A significant negative correlation was found between the degree of satisfaction with the cat and occurrence of house soiling; thus, some behavioral problems may deteriorate the relationship between the owner and the cat. PMID:24419973

NASA Ames Fluid Mechanics Laboratory research briefs

NASA Technical Reports Server (NTRS)

Davis, Sanford (Editor)

1994-01-01

The Ames Fluid Mechanics Laboratory research program is presented in a series of research briefs. Nineteen projects covering aeronautical fluid mechanics and related areas are discussed and augmented with the publication and presentation output of the Branch for the period 1990-1993.

ARC-2009-ACD09-0049-174

NASA Image and Video Library

2009-03-14

FIRST Robotics Competition 'Lunacy' hosted by NASA at San Jose State University Event Center. For Inspiration and Recognition of Science and Technology let the games begin. with Mark Leon, Ames Research Robotics Alliance Project Lead encourages the Ames Space Cookies team #1868

ARC-2007-ACD07-0145-016

NASA Image and Video Library

2007-08-01

NASA Officials gather at Ames Research Center to discuss Spaceship development progress. Constellation is developing the Orion spacecraft and Ares rockets to support an American return to the moon by 2020. (with Kelly Humphries, JSC - on detail to Ames PAO '07-'08)

Ames Lab 101: Single Crystal Growth

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schlagel, Deborah

2013-09-27

Ames Laboratory scientist Deborah Schlagel talks about the Lab's research in growing single crystals of various metals and alloys. The single crystal samples are vital to researchers' understanding of the characteristics of a materials and what gives these materials their particular properties.

A Classroom Modification of the Ames Test.

ERIC Educational Resources Information Center

Yavornitzky, Joseph; Trzeciak, Victor

1979-01-01

A modification of the Ames test for detecting carcinogens and mutagens using a strain of bacteria is described. A suggestion is given for checking the correctness of procedures by using particular hair dyes which have been shown to be mutogenic. (Author/SA)

State of the Lab Address

ScienceCinema

King, Alex

2018-05-07

In his third-annual State of the Lab address, Ames Laboratory Director Alex King called the past year one of "quiet but strong progress" and called for Ames Laboratory to continue to build on its strengths while responding to changing expectations for energy research.

Ames Lab 101: Single Crystal Growth

ScienceCinema

Schlagel, Deborah

2018-01-16

Ames Laboratory scientist Deborah Schlagel talks about the Lab's research in growing single crystals of various metals and alloys. The single crystal samples are vital to researchers' understanding of the characteristics of a materials and what gives these materials their particular properties.

State of the Lab Address

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, Alex

2010-01-01

In his third-annual State of the Lab address, Ames Laboratory Director Alex King called the past year one of "quiet but strong progress" and called for Ames Laboratory to continue to build on its strengths while responding to changing expectations for energy research.

ARC-2006-ACD06-0213-013

NASA Image and Video Library

2006-09-25

Ames and Moffett Field (MFA) historical sites and memorials Entry of building N-210 Ames Flight System Research Laboratory architectural detail. Eastside showing NACA brass inset wing over front doors, light fixtures flanking the doors and glass brick window wall above the doors

ARC-2006-ACD06-0213-014

NASA Image and Video Library

2006-09-25

Ames and Moffett Field (MFA) historical sites and memorials Entry of building N-210 Ames Flight System Research Laboratory architectural detail. Eastside showing NACA brass inset wing over front doors, light fixtures flanking the doors and glass brick window wall above the doors

ARC-2009-ACD09-0260-012

NASA Image and Video Library

2009-12-09

2009 Awards Ceremony; 2008 Government Invention of the Year Award, 2009 Software of the Year Award sponsored by Ames Innovative Partnerships Program Office. Patent Awards, Steve Zornetzer, Associate Director Ames Research Center presenting: Anthony Strawa for Photometer for Tracking a Moving Light Source.

ARC-2008-ACD08-0260-024

NASA Image and Video Library

2008-11-04

K-10 (red) plaentary rover at Marscape (Ames Mars Yard): with prototype flight control team remotely operating K-10 'Red' from Ames Future Flight Centeral (FFC) Simulator, L-R; Kip Hodges, Mark Helper, Marwan Hussein, Pascal Lee, Melissa Rice, Trey Smith, David Lees

ARC-2008-ACD07-0073-468

NASA Image and Video Library

2008-01-14

LCROSS in Ames clean room N-240- securing the special made crate for transfer to Northrup Grumman Redondo Beach, CA where more calibration will be done before finally being sent for mating with the LRO spacecraft with Steve Ord, Ames Project Management Office

2016 Summer Series Highlights - Inspire the Imagination

NASA Image and Video Library

2017-01-20

Highlights of the 2016 Summer Series of lectures at NASA's Ames Research Center in Silicon Valley. Sponsored by the Ames Office of the Chief Scientist, the talks are designed to generate innovative discussion, as well as inspire and catalyze scientific progress.

Research and technology

NASA Technical Reports Server (NTRS)

1984-01-01

Various research and technology activities at Ames Moffett and Ames Dryden are described. Highlights of these accomplishments indicate the Center's varied and highly productive research efforts for 1984. The research is divided into three subject areas, which are: Aeronautics, Life Science and Space Science and Applications.

Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

NASA Image and Video Library

2017-02-15

Hunjoo Kim, NASA JPL (Left) and Ashley Karp, NASA JPL (Right) attaching heat sensors the Peregrine Hybrid Rocket Engine prior to its test at the Outdoor Aerodynamic Research Facility (OARF, N-249) at NASA’s Ames Research Center.

Terminal Area ATM Research at NASA Ames

NASA Technical Reports Server (NTRS)

Tobias, Leonard

1997-01-01

The presentation will highlight the following: (1) A brief review of ATC research underway 15 years ago; (2) A summary of Terminal Area ATM Tool Development ongoing at NASA Ames; and (3) A projection of research activities 10-15 years from now.

ARC-2009-ACD09-0054-005

NASA Image and Video Library

2009-04-09

Yuri's Night 2009 held at the California Acaemy of Sciences in San Francisco, California from left in blue NASA jacket Mark Leon, Pete Worden, Lew Braxton, and Dana Bolles of Ames look over the the NASA Ames robotics team the Cheesy Poofs robot)

Task Allocation for Single Pilot Operations: A Role for the Ground

NASA Technical Reports Server (NTRS)

Johnson, Walter; Lachter, Joel; Feary, Mike; Comerford, Doreen; Battiste, Vernol; Mogford, Richard

2012-01-01

Researchers at NASA Ames Research Center and NASA Langley Research Center are jointly investigating issues associated with potential configurations for an environment in which a single pilot, or reduced crew, might operate. The research summarized in this document represents several of the efforts being put forth at NASA Ames Research Center. Specifically, researchers at NASA Ames Research Center coordinated and hosted a technical interchange meeting in order to gain insight from members of the aviation community. A description of this meeting and the findings are presented first. Thereafter, plans for ensuing research are presented.

A Survey of Knowledge Management Research & Development at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Keller, Richard M.; Clancy, Daniel (Technical Monitor)

2002-01-01

This chapter catalogs knowledge management research and development activities at NASA Ames Research Center as of April 2002. A general categorization scheme for knowledge management systems is first introduced. This categorization scheme divides knowledge management capabilities into five broad categories: knowledge capture, knowledge preservation, knowledge augmentation, knowledge dissemination, and knowledge infrastructure. Each of nearly 30 knowledge management systems developed at Ames is then classified according to this system. Finally, a capsule description of each system is presented along with information on deployment status, funding sources, contact information, and both published and internet-based references.

A Survey of Public Opinion on Cat (Felis catus) Predation and the Future Direction of Cat Management in New Zealand.

PubMed

Walker, Jessica K; Bruce, Stephanie J; Dale, Arnja R

2017-07-03

Cat predation is a prominent issue in New Zealand that provokes strong and opposing views. We explored, via 1011 face-to-face questionnaires, public opinion on (a) support for a National Cat Management Strategy (78% support); (b) concern regarding predation of wildlife by owned and un-owned cats (managed stray, unmanaged stray, and feral cats); (c) the acceptability of management techniques for owned cats; and (d) the acceptability of population management techniques for un-owned cats. The highest concern was expressed regarding the predation of non-native and native wildlife by feral cats (60 and 86% repectively), followed by unmanaged stray cats (59 and 86% respectively), managed stray cats (54 and 82% respectively), and finally owned cats (38 and 69% repectively). Limits to the number of cats owned and cat restriction zones received high levels of support (>65%), and compulsory microchipping, Council registration, and de-sexing were supported by the majority (>58%). Public support of population control methods for unowned cats was explored, and the influence of participant demographic variables on responses is described. These findings provide insight into public opinion regarding the management of cats in New Zealand, which should be considered during the development of legislation in this area.

Left atrial function in cats with left-sided cardiac disease and pleural effusion or pulmonary edema.

PubMed

Johns, S M; Nelson, O L; Gay, J M

2012-01-01

Congestive heart failure (CHF) in cats with left-sided heart disease is sometimes manifest as pleural effusion, in other cases as pulmonary edema. Those cats with pleural effusion have more severe left atrial (LA) dysfunction than cats with pulmonary edema. 30 healthy cats, 22 cats with pleural effusion, and 12 cats with pulmonary edema. All cats were client owned. Retrospective study. Measurements of LA size and function were made using commercial software on archived echocardiograms. Cases were identified through searches of medical records and of archived echocardiograms for cats with these conditions. There was no difference (P = .3) in LA size between cats with pleural effusion and cats with pulmonary edema. Cats with pleural effusion had poorer (P = .04) LA active emptying and increased (P = .006) right ventricular (RV) diameter when compared with cats with pulmonary edema and healthy cats. Cats that exhibited LA active emptying of <7.9%, total emptying of <13.6% (diameter) or <19.4% (area), or RV diameter of >3.6 mm were significantly (P < .001) more likely to manifest pleural effusion. Poorer LA function and increased RV dimensions are associated with pleural effusion in cats with left-sided heart disease. Copyright © 2012 by the American College of Veterinary Internal Medicine.

Satellite communications provisions on NASA Ames instrumented aircraft platforms for Earth science research/applications

NASA Technical Reports Server (NTRS)

Shameson, L.; Brass, J. A.; Hanratty, J. J.; Roberts, A. C.; Wegener, S. S.

1995-01-01

Earth science activities at NASA Ames are research in atmospheric and ecosystem science, development of remote sensing and in situ sampling instruments, and their integration into scientific research platform aircraft. The use of satellite communications can greatly extend the capability of these agency research platform aircraft. Current projects and plans involve satellite links on the Perseus UAV and the ER-2 via TDRSS and a proposed experiment on the NASA Advanced Communications Technology Satellite. Provisions for data links on the Perseus research platform, via TDRSS S-band multiple access service, have been developed and are being tested. Test flights at Dryden are planned to demonstrate successful end-to-end data transfer. A Unisys Corp. airborne satcom STARLink system is being integrated into an Ames ER-2 aircraft. This equipment will support multiple data rates up to 43 Mb/s each via the TDRS S Ku-band single access service. The first flight mission for this high-rate link is planned for August 1995. Ames and JPL have proposed an ACTS experiment to use real-time satellite communications to improve wildfire research campaigns. Researchers and fire management teams making use of instrumented aircraft platforms at a prescribed burn site will be able to communicate with experts at Ames, the U.S. Forest Service, and emergency response agencies.

Gap junctions between accessory medulla neurons appear to synchronize circadian clock cells of the cockroach Leucophaea maderae.

PubMed

Schneider, Nils-Lasse; Stengl, Monika

2006-03-01

The temporal organization of physiological and behavioral states is controlled by circadian clocks in apparently all eukaryotic organisms. In the cockroach Leucophaea maderae lesion and transplantation studies located the circadian pacemaker in the accessory medulla (AMe). The AMe is densely innervated by gamma-aminobutyric acid (GABA)-immunoreactive and peptidergic neurons, among them the pigment-dispersing factor immunoreactive circadian pacemaker candidates. The large majority of cells of the cockroach AMe spike regularly and synchronously in the gamma frequency range of 25-70 Hz as a result of synaptic and nonsynaptic coupling. Although GABAergic coupling forms assemblies of phase-locked cells, in the absence of synaptic release the cells remain synchronized but fire now at a stable phase difference. To determine whether these coupling mechanisms of AMe neurons, which are independent of synaptic release, are based on electrical synapses between the circadian pacemaker cells the gap-junction blockers halothane, octanol, and carbenoxolone were used in the presence and absence of synaptic transmission. Here, we show that different populations of AMe neurons appear to be coupled by gap junctions to maintain synchrony at a stable phase difference. This synchronization by gap junctions is a prerequisite to phase-locked assembly formation by synaptic interactions and to synchronous gamma-type action potential oscillations within the circadian clock.

Floods of June 17, 1990, and July 9, 1993, along Squaw Creek and the South Skunk River in Ames, Iowa, and vicinity

USGS Publications Warehouse

Einhellig, R.F.; Eash, D.A.

1996-01-01

Water-surface-elevation profiles and peak discharges for the floods of June 17, 1990, and July 9, 1993, along Squaw Creek and the South Skunk River, in Ames, Iowa, are presented in this report. The maximum flood-peak discharge of 24,300 cubic feet per second for the streamflow-gaging station on Squaw Creek at Ames, Iowa (station number 05470500) occurred on July 9, 1993. This discharge was 80 percent larger than the 100-year recurrence-interval discharge and exceeded the previous record flood-peak discharge of June 17, 1990, by 94 percent. The July 9, 1993, flood-peak discharge of 26,500 cubic feet per second on the South Skunk River below Squaw Creek (station number 05471000) was also a peak of record, exceeding the previous record flood-peak discharge of June 27, 1975, by 80 percent, and the 100-year recurrence-interval discharge by 60 percent. A flood history describes rainfall conditions for floods that occurred during 1990 and 1993. The report also includes information on flood stages and discharges and floodflow frequencies for the active gaging stations in the vicinity of Ames, Iowa, and on temporary bench marks and reference points in the Squaw Creek and South Skunk River Basins near Ames, Iowa.

Plasma free metanephrines in healthy cats, cats with non-adrenal disease and a cat with suspected phaeochromocytoma.

PubMed

Wimpole, Justin A; Adagra, Carl F M; Billson, Mark F; Pillai, Dilo N; Foster, Darren J

2010-06-01

Phaeochromocytomas are catecholamine-secreting tumours of the adrenal glands and are rare in cats. Plasma metanephrine levels are widely considered the diagnostic test of choice for phaeochromocytoma in people but have not been investigated in cats. In this study plasma free normetanephrine and metanephrine levels were measured using high-pressure liquid chromatography in healthy cats, sick cats with non-adrenal disease and in a cat with a suspected phaeochromocytoma. Plasma normetanephrine was significantly higher in sick cats with non-adrenal disease compared to healthy cats (P<0.05) and markedly higher in the cat with a suspected phaeochromocytoma when compared to either group. Plasma metanephrine was not significantly different in any of the groups. This study establishes a first-line guide reference range for plasma metanephrine and normetanephrine levels in healthy cats and cats with non-adrenal disease. These results provide rationale for further studies to establish the use of plasma normetanephrine levels as a potential diagnostic test for phaeochromocytoma in the cat. Copyright 2009 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.

Systolic blood pressure, routine kidney variables and renal ultrasonographic findings in cats naturally infected with feline immunodeficiency virus.

PubMed

Taffin, Elien Rl; Paepe, Dominique; Ghys, Liesbeth Fe; De Roover, Katrien; Van de Maele, Isabel; Saunders, Jimmy H; Duchateau, Luc; Daminet, Sylvie

2017-06-01

Objectives Hypertension is a common cause of proteinuria in HIV-infected people. In cats, feline immunodeficiency virus (FIV) infection appears to be associated with proteinuria. Therefore, the results from systolic blood pressure (SBP) measurements in naturally infected FIV-positive cats were reviewed to assess whether hypertension contributes to the observed proteinuria in these cats. Ultrasonographic findings in FIV-positive cats were reviewed to complete renal assessment and to extend the scant knowledge on renal ultrasonography in cats. Methods Data from client-owned, naturally infected FIV-positive cats were retrospectively reviewed. To obtain a control group, records were reviewed from age-matched, privately owned, FIV-negative cats. Results Data from 91 FIV-infected and 113 control cats were compared. FIV-infected cats showed a significantly lower SBP ( P <0.0001) and significantly fewer FIV-infected cats were hypertensive (⩾160 mmHg) compared with control cats ( P = 0.025). The prevalence of renal azotaemia did not significantly differ between groups, although FIV-infected cats had significantly lower urine specific gravity (USG) ( P = 0.0273) and a higher incidence of USG below 1.035 ( P = 0.043). Urinary protein:creatinine ratio (UPC) was significantly higher in FIV-infected cats ( P = 0.0005) and proteinuria (UPC >0.4) occurred more frequently in FIV-infected cats ( P <0.001). Renal ultrasonography showed abnormalities in 60/91 FIV-infected cats, with hyperechogenic cortices in 39/91 and enlarged kidneys in 31/91. Conclusions and relevance Hypertension can be excluded as a common cause of renal damage leading to proteinuria in FIV-infected cats. Proteinuria and poorly concentrated urine are common in naturally infected FIV-positive cats, in contrast to azotaemia. Clinicians should cautiously interpret ultrasonographic abnormalities as these occur in over half of FIV-infected cats.

Who's behind that mask and cape? The Asian leopard cat's Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed.

PubMed

Gershony, L C; Penedo, M C T; Davis, B W; Murphy, W J; Helps, C R; Lyons, L A

2014-12-01

Coat colours and patterns are highly variable in cats and are determined mainly by several genes with Mendelian inheritance. A 2-bp deletion in agouti signalling protein (ASIP) is associated with melanism in domestic cats. Bengal cats are hybrids between domestic cats and Asian leopard cats (Prionailurus bengalensis), and the charcoal coat colouration/pattern in Bengals presents as a possible incomplete melanism. The complete coding region of ASIP was directly sequenced in Asian leopard, domestic and Bengal cats. Twenty-seven variants were identified between domestic and leopard cats and were investigated in Bengals and Savannahs, a hybrid with servals (Leptailurus serval). The leopard cat ASIP haplotype was distinguished from domestic cat by four synonymous and four non-synonymous exonic SNPs, as well as 19 intronic variants, including a 42-bp deletion in intron 4. Fifty-six of 64 reported charcoal cats were compound heterozygotes at ASIP, with leopard cat agouti (A(P) (be) ) and domestic cat non-agouti (a) haplotypes. Twenty-four Bengals had an additional unique haplotype (A2) for exon 2 that was not identified in leopard cats, servals or jungle cats (Felis chaus). The compound heterozygote state suggests the leopard cat allele, in combination with the recessive non-agouti allele, influences Bengal markings, producing a darker, yet not completely melanistic coat. This is the first validation of a leopard cat allele segregating in the Bengal breed and likely affecting their overall pelage phenotype. Genetic testing services need to be aware of the possible segregation of wild felid alleles in all assays performed on hybrid cats. © 2014 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics.

Efficient Probabilistic Diagnostics for Electrical Power Systems

NASA Technical Reports Server (NTRS)

Mengshoel, Ole J.; Chavira, Mark; Cascio, Keith; Poll, Scott; Darwiche, Adnan; Uckun, Serdar

2008-01-01

We consider in this work the probabilistic approach to model-based diagnosis when applied to electrical power systems (EPSs). Our probabilistic approach is formally well-founded, as it based on Bayesian networks and arithmetic circuits. We investigate the diagnostic task known as fault isolation, and pay special attention to meeting two of the main challenges . model development and real-time reasoning . often associated with real-world application of model-based diagnosis technologies. To address the challenge of model development, we develop a systematic approach to representing electrical power systems as Bayesian networks, supported by an easy-to-use speci.cation language. To address the real-time reasoning challenge, we compile Bayesian networks into arithmetic circuits. Arithmetic circuit evaluation supports real-time diagnosis by being predictable and fast. In essence, we introduce a high-level EPS speci.cation language from which Bayesian networks that can diagnose multiple simultaneous failures are auto-generated, and we illustrate the feasibility of using arithmetic circuits, compiled from Bayesian networks, for real-time diagnosis on real-world EPSs of interest to NASA. The experimental system is a real-world EPS, namely the Advanced Diagnostic and Prognostic Testbed (ADAPT) located at the NASA Ames Research Center. In experiments with the ADAPT Bayesian network, which currently contains 503 discrete nodes and 579 edges, we .nd high diagnostic accuracy in scenarios where one to three faults, both in components and sensors, were inserted. The time taken to compute the most probable explanation using arithmetic circuits has a small mean of 0.2625 milliseconds and standard deviation of 0.2028 milliseconds. In experiments with data from ADAPT we also show that arithmetic circuit evaluation substantially outperforms joint tree propagation and variable elimination, two alternative algorithms for diagnosis using Bayesian network inference.

ARC-2011-ACD11-0150-039

NASA Image and Video Library

2011-08-24

STS-135 Space Shuttle's final crew of Astronauts Ferguson, Hurley, Magnus and Walheim visit Ames for a mission/project briefing and with a meet and greet of Ames personnel. STS-135 Mission Commander Ferguson presents Deb Feng, Acting Deputy Center Director with a mission remembrance.

44. Photograph of an original construction drawing, dated August 1927, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. Photograph of an original construction drawing, dated August 1927, in the possession of Facilities Planning Office, Iowa State University, Ames, Iowa. GROUND FLOOR PLAN; SHEET NO. 2 OF 10 - Dairy Industry Building, Iowa State University campus, Ames, Story County, IA

ARC-2010-ACD10-0242-018

NASA Image and Video Library

2010-12-17

German Deligation visits Ames SOFIA Science Office for briefing and enjoy a Ames tour. .Jochen Homann, Sectretary of State, Federal Ministry of Economics and Technology, speaks with Robert R. 'Bob' Meyer, NASA SOFIA Program Manager (based at the Dryden Aircraft Operations Facility, DAOF, Palmdale, California).

Synthesis of (±)-Tetrapetalone A-Me Aglycon**

PubMed Central

Carlsen, Peter N.; Mann, Tyler J.; Hoveyda, Amir H.

2014-01-01

The first synthesis of (±)-tetrapetalone A-Me aglycon is described. Key bond-forming reactions include Nazarov cyclization, a ring-closing metathesis (RCM) promoted with complete diastereoselectivity by a chiral Mo-based complex, tandem conjugate reduction-intramolecular aldol cyclization, and oxidative dearomatization. PMID:25045072

ARC-1965-AC-36014

NASA Image and Video Library

1965-12-15

6 degree V/STOL Control Systems Research All Axes, Simulator (simulator pilot: Richard K Greif) at the Ames Research Center, Moffett Field, CA Note: Used in publication in Flight Research at Ames; 57 Years of Development and Validation of Aeronautical Technology NASA SP-1998-3300 fig. 113

Evaluation of fenbendazole for treatment of Giardia infection in cats concurrently infected with Cryptosporidium parvum.

PubMed

Keith, Carey L; Radecki, Steven V; Lappin, Michael R

2003-08-01

To determine whether fenbendazole effectively eliminates Giardia organisms from chronically infected cats that have a concurrent Cryptosporidium parvum infection. 16 clinically normal cats. Eight cats with chronic concurrent Giardia and C parvum infections received fenbendazole (50 mg/kg, PO, q 24 h) for 5 days (treatment-group cats). Feces from each cat were collected and processed 3 days weekly for 23 days after treatment. By use of an immunofluorescent assay for detection of Giardia lamblia cysts and C parvum oocysts, organism numbers were counted and scored. Fecal results from treatment-group cats were compared with those of 8 untreated cats with Giardia infection but no C parvum infection (control-group cats). Four of 8 treatment-group cats had consistently negative results for Giardia infection after treatment. These 4 cats had consistently positive results for C parvum oocysts prior to treatment and consistently negative results after treatment. One treatment-group cat had positive results for cysts on all fecal samples, and 3 treatment-group cats had 1 to 3 negative results and then resumed shedding large numbers of cysts; each of these cats had consistently positive results for C parvum oocysts. When compared with control-group cats, treatment-group cats shed less Giardia cysts during week 1 after treatment but not during week 2. Administration of fenbendazole decreases Giardia cyst shedding to less than detectable numbers in some cats. In our study, persistent C parvum infection may have been associated with failure of fenbendazole to eliminate Giardia infection.

Interspecies Transmission of Feline Immunodeficiency Virus from the Domestic Cat to the Tsushima Cat (Felis bengalensis euptilura) in the Wild

PubMed Central

Nishimura, Yoshiaki; Goto, Yuko; Yoneda, Kumiko; Endo, Yasuyuki; Mizuno, Takuya; Hamachi, Masaharu; Maruyama, Hiroyuki; Kinoshita, Hirotoshi; Koga, Susumu; Komori, Mitsuru; Fushuku, Seigo; Ushinohama, Kanji; Akuzawa, Masao; Watari, Toshihiro; Hasegawa, Atsuhiko; Tsujimoto, Hajime

1999-01-01

Feline immunodeficiency virus (FIV) was isolated from a wild-caught Tsushima cat (Felis bengalensis euptilura), an endangered Japanese nondomestic subspecies of leopard cat (F. bengalensis). Phylogenetic analysis of the env gene sequences indicated that the FIV from the Tsushima cat belonged to a cluster of subtype D FIVs from domestic cats. FIVs from both the Tsushima cat and the domestic cat showed similar levels of replication and cytopathicity in lymphoid cell lines derived from these two species. The results indicated the occurrence of interspecies transmission of FIV from the domestic cat to the Tsushima cat in the wild. PMID:10438892

Serum and urinary cystatin C in cats with feline immunodeficiency virus infection and cats with hyperthyroidism.

PubMed

Ghys, Liesbeth Fe; Paepe, Dominique; Taffin, Elien Rl; Vandermeulen, Eva; Duchateau, Luc; Smets, Pascale My; Delanghe, Joris; Daminet, Sylvie

2016-08-01

The objective of this study was to investigate serum cystatin C (sCysC) and urinary cystatin C (uCysC) in cats with hyperthyroidism and cats with feline immunodeficiency virus (FIV). Thirty cats with FIV, 26 hyperthyroid cats and 28 healthy cats were included. sCysC and uCysC:creatinine (uCysC/uCr) ratio were measured with a human particle-enhanced nephelometric immunoassay, previously validated for feline CysC measurement. Routine renal variables (serum creatinine [sCr], urine specific gravity, urinary protein:creatinine ratio [UPC]) were also measured in the three groups. Cats with hyperthyroidism had significantly higher sCysC and higher uCysC/uCr ratio, lower sCr and a higher UPC than healthy cats. Cats with FIV infection did not show a significantly higher sCysC concentration but had a significantly higher sCr and UPC than healthy cats. uCysC could be detected in only four of them. This study demonstrated that sCysC is increased in cats with hyperthyroidism, in contrast with sCr, but not in cats with FIV. Many hyperthyroid cats, but only four cats with FIV, had an elevated uCysC/uCr ratio. Further studies may reveal if uCysC might be a valuable marker for tubular dysfunction in cats. © The Author(s) 2015.

Energy requirement and food intake behaviour in young adult intact male cats with and without predisposition to overweight.

PubMed

Wichert, Brigitta; Trossen, Julia; Uebelhart, Daniel; Wanner, Marcel; Hartnack, Sonja

2012-01-01

Obesity is a common problem in cats. In the experimental cat family of the institute of animal nutrition besides a "normal" lean phenotype, cats with predisposition to an overweight phenotype are present. To investigate energy requirements and food intake behaviour of intact male cats of different phenotypes, six "normal" lean cats (GL) and six cats disposed to overweight (GO) were used. At the beginning of the experiment, all cats had an ideal body condition score of 5. To reach this the GO cats had to pass a weight-loss program. Energy requirements of the cats were determined using respiration chambers, whereas the amount and frequency of food intake was measured with a feeding station recording the data automatically. Energy requirement at weight constancy of the GO cats was even on fat-free mass (FFM) significantly (P = 0.02) lower (162.6 kJ/kg FFM/d) than that of the "normal" lean cats (246 kJ/kg FFM/d). The GO cats also showed a higher food intake 34.5 ± 1.5 g dry matter/kg body weight(0.67) compared to the GL cats (24.0 ± 2.1 g dry matter/kg body weight(0.67))(P = 0.001). In conclusion quantifiable differences in food intake and behaviour in cats predisposed to overweight compared to "normal" lean cats were found.

Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative.

PubMed

Veronese, Nicola; Stubbs, Brendon; Noale, Marianna; Solmi, Marco; Luchini, Claudio; Maggi, Stefania

2016-11-01

The Mediterranean diet has positively influenced various medical conditions, but only a paucity of studies has considered the relation between the Mediterranean diet and quality of life (QOL) among people living in North America. We investigated whether a higher adherence to the Mediterranean diet (aMED) was associated with better QOL and decreased pain, stiffness, disability, and depression in a large cohort of North Americans from the Osteoarthritis Initiative. aMED was evaluated through a validated Mediterranean diet score categorized into quintiles. Outcomes of interest were QOL [assessed with the 12-Item Short-Form Health Outcome Survey (SF-12)]; disability, pain, and stiffness [assessed in both knees with the Western Ontario and McMaster Universities Arthritis Index (WOMAC)]; and depressive symptoms [assessed with the Center for Epidemiologic Studies Depression Scale (CES-D)]. Of the 4470 participants (2605 women; mean age: 61.3 y), those with a higher aMED had significantly more favorable scores on all outcomes investigated (P < 0.0001 for all comparisons). After adjustment for potential confounders in linear regression analyses, a higher aMED was significantly associated with a higher SF-12 physical composite scale value (β: 0.10; 95% CI: 0.05, 0.15; P < 0.0001), lower WOMAC scores (except for stiffness), and lower CES-D scores (β: -0.05; 95% CI: -0.09, -0.01; P = 0.01). An adjusted logistic regression analysis, taking as reference those in the 2 highest quintiles of the aMED score, confirmed these findings. Higher aMED is associated with better QOL and decreased pain, disability, and depressive symptoms. This trial was registered at clinicaltrials.gov as NCT00080171. © 2016 American Society for Nutrition.

Tracking emerging mycotoxins in food: development of an LC-MS/MS method for free and modified Alternaria toxins.

PubMed

Puntscher, Hannes; Kütt, Mary-Liis; Skrinjar, Philipp; Mikula, Hannes; Podlech, Joachim; Fröhlich, Johannes; Marko, Doris; Warth, Benedikt

2018-05-16

Mycotoxins produced by Alternaria fungi are ubiquitous food contaminants, but analytical methods for generating comprehensive exposure data are rare. We describe the development of an LC-MS/MS method covering 17 toxins for investigating the natural occurrence of free and modified Alternaria toxins in tomato sauce, sunflower seed oil, and wheat flour. Target analytes included alternariol (AOH), AOH-3-glucoside, AOH-9-glucoside, AOH-3-sulfate, alternariol monomethyl ether (AME), AME-3-glucoside, AME-3-sulfate, altenuene, isoaltenuene, tenuazonic acid (TeA), tentoxin (TEN), altertoxin I and II, alterperylenol, stemphyltoxin III, altenusin, and altenuic acid III. Extensive optimization resulted in a time- and cost-effective sample preparation protocol and a chromatographic baseline separation of included isomers. Overall, adequate limits of detection (0.03-9 ng/g) and quantitation (0.6-18 ng/g), intermediate precision (9-44%), and relative recovery values (75-100%) were achieved. However, stemphyltoxin III, AOH-3-sulfate, AME-3-sulfate, altenusin, and altenuic acid III showed recoveries in wheat flour below 70%, while their performance was stable and reproducible. Our pilot study with samples from the Austrian retail market demonstrated that tomato sauces (n = 12) contained AOH, AME, TeA, and TEN in concentrations up to 20, 4, 322, and 0.6 ng/g, while sunflower seed oil (n = 7) and wheat flour samples (n = 9) were contaminated at comparatively lower levels. Interestingly and of relevance for risk assessment, AOH-9-glucoside, discovered for the first time in naturally contaminated food items, and AME-3-sulfate were found in concentrations similar to their parent toxins. In conclusion, the established multi-analyte method proved to be fit for purpose for generating comprehensive Alternaria toxin occurrence data in different food matrices. Graphical abstract ᅟ.

Occurrence of aminoglycoside-modifying enzymes among isolates of Escherichia coli exhibiting high levels of aminoglycoside resistance isolated from Korean cattle farms.

PubMed

Belaynehe, Kuastros Mekonnen; Shin, Seung Won; Hong-Tae, Park; Yoo, Han Sang

2017-08-01

This study investigated 247 Escherichia coli isolates collected from four cattle farms to characterize aminoglycoside-modifying enzyme (AME) genes, their plasmid replicons and transferability. Out of 247 isolates a high number of isolates (total 202; 81.78%) were found to be resistant to various antibiotics by disc diffusion. Of the 247 strains, 139 (56.3%) were resistant to streptomycin, and other antibiotic resistances followed as tetracycline (12.15%), ampicillin (7%), chloramphenicol (5.7%) and trimethoprim-sulfamethoxazole (0.8%). Among 247 isolates B1 was the predominant phylogenetic group identified comprising 151 isolates (61.1%), followed by groups A (27.9%), D (7%) and B2 (4%). Out of 139 isolates investigated for AME, 130 (93.5%) isolates carried at least one AME gene. aph3″-1a and aph3″-1b (46%) were the principal genes detected, followed by aac3-IVa (34.5%). ant2″-1a was the least detected gene (2.2%). Nine (6.5%) strains carried no AME genes. Twelve (63.2%) among 19 isolates transferred an AME gene to a recipient and aph3΄-1a was the dominant transferred gene. Transferability mainly occurred via the IncFIB replicon type (52.6%). Pulsed-field gel electrophoresis typing demonstrated a higher degree of diversity with 14 distinct cluster types. This result suggests that commensal microflora from food-producing animals has a tremendous ability to harbor and transfer AME genes, and poses a potential risk by dissemination of resistance to humans through the food chain. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Interlaboratory comparison of mutagenesis testing of coal fly ash derived from differenct coal conversion technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chrisp, C.; Hobbs, C.; Clark, R.

1979-01-01

This experiment showed that mutagenicity of fly ash derived from different coal conversion technologies, as determined by the Ames plate incorporation test, was similar in all three laboratories. The differences in mutagenic activity of each fly ash between laboratories with different solvent extraction methods were no greater than one order of magnitude. In addition, there were much smaller, but still significant differences in mutagenic activity between laboratories when the same solvent extract of a particular fly ash was tested in each laboratory. There were also significant differences in mutagenicity of the positive control mutagen (maximum of fivefold) between laboratories. Becausemore » of this difference in Ames test sensitivity between laboratories, the influence of the solvent extraction methods on differences in mutagenicity was not clear. However, the data suggested that either there were significant differences in the degree of sensitivity of Ames tests for different complex mixtures within each laboratory, or else there were differences in mutagen extraction efficiency between different solvent extraction methods. Both Ames test sensitivity and solvent extraction may be important. Further work would be necessary to separate the contribution of these two factors. An important aspect of further work would be to separate the contribution of the innate sensitivity of substrains of Ames tester strains in each laboratory from the possible effects of differences in Ames testing methodology. This could be done by testing the same extracts of fly ash and positive control mutagens with substrains of tester strains exchanged between laboratories. This work also implies that caution should be exercised in assuming that the same solvent would have the same efficiency for extraction of mutagens from different fly ashes even within the same laboratory.« less

Robotic Rock Classification

NASA Technical Reports Server (NTRS)

Hebert, Martial

1999-01-01

This report describes a three-month research program undertook jointly by the Robotics Institute at Carnegie Mellon University and Ames Research Center as part of the Ames' Joint Research Initiative (JRI.) The work was conducted at the Ames Research Center by Mr. Liam Pedersen, a graduate student in the CMU Ph.D. program in Robotics under the supervision Dr. Ted Roush at the Space Science Division of the Ames Research Center from May 15 1999 to August 15, 1999. Dr. Martial Hebert is Mr. Pedersen's research adviser at CMU and is Principal Investigator of this Grant. The goal of this project is to investigate and implement methods suitable for a robotic rover to autonomously identify rocks and minerals in its vicinity, and to statistically characterize the local geological environment. Although primary sensors for these tasks are a reflection spectrometer and color camera, the goal is to create a framework under which data from multiple sensors, and multiple readings on the same object, can be combined in a principled manner. Furthermore, it is envisioned that knowledge of the local area, either a priori or gathered by the robot, will be used to improve classification accuracy. The key results obtained during this project are: The continuation of the development of a rock classifier; development of theoretical statistical methods; development of methods for evaluating and selecting sensors; and experimentation with data mining techniques on the Ames spectral library. The results of this work are being applied at CMU, in particular in the context of the Winter 99 Antarctica expedition in which the classification techniques will be used on the Nomad robot. Conversely, the software developed based on those techniques will continue to be made available to NASA Ames and the data collected from the Nomad experiments will also be made available.