The J3 SCR model applied to resonant converter simulation

NASA Technical Reports Server (NTRS)

Avant, R. L.; Lee, F. C. Y.

1985-01-01

The J3 SCR model is a continuous topology computer model for the SCR. Its circuit analog and parameter estimation procedure are uniformly applicable to popular computer-aided design and analysis programs such as SPICE2 and SCEPTRE. The circuit analog is based on the intrinsic three pn junction structure of the SCR. The parameter estimation procedure requires only manufacturer's specification sheet quantities as a data base.

ENGINEERING APPLICATIONS OF ANALOG COMPUTERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bryant, L.T.; Janicke, M.J.; Just, L.C.

1961-02-01

Six examples are given of the application of analog computers in the fields of reactor engineering, heat transfer, and dynamics: deceleration of a reactor control rod by dashpot, pressure variations through a packed bed, reactor kinetics over many decades with thermal feedback (simulation of a TREAT transient), vibrating system with two degrees of freedom, temperature distribution in a radiating fin, and temperature distribution in an irfinite slab with variable thermal properties. (D.L.C.)

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay.

PubMed

Hsu, Chia-Jen; Hsu, Wen-Chi; Lee, Der-Jay; Liu, An-Lun; Chang, Chia-Ming; Shih, Huei-Jhen; Huang, Wun-Han; Lee-Chen, Guey-Jen; Hsieh-Li, Hsiu Mei; Lee, Guan-Chiun; Sun, Ying-Chieh

2017-08-01

GSK3β kinase is a noteworthy target for discovery of the drugs that will be used to treat several diseases. In the effort to identify a new inhibitor lead compound, we utilized thermodynamic integration (TI)-molecular dynamics (MD) simulation and kinase assay to investigate the bindings between GSK3β kinase and five compounds that were analogous to a known inhibitor with an available crystal structure. TI-MD simulations of the first two compounds (analogs 1 and 2) were used for calibration. The computed binding affinities of analogs 1 and 2 agreed well with the experimental results. The rest three compounds (analogs 3-5) were newly obtained from a database search, and their affinity data were newly measured in our labs. TI-MD simulations predicted the binding modes and the computed ΔΔG values have a reasonably good correlation with the experimental affinity data. These newly identified inhibitors appear to be new leads according to our survey of GSK3β inhibitors listed in recent review articles. The predicted binding modes of these compounds should aid in designing new derivatives of these compounds in the future. © 2017 John Wiley & Sons A/S.

Demonstration of Inexact Computing Implemented in the JPEG Compression Algorithm using Probabilistic Boolean Logic applied to CMOS Components

DTIC Science & Technology

2015-12-24

Signal to Noise Ratio SPICE Simulation Program with Integrated Circuit Emphasis TIFF Tagged Image File Format USC University of Southern California xvii...sources can create errors in digital circuits. These effects can be simulated using Simulation Program with Integrated Circuit Emphasis ( SPICE ) or...compute summary statistics. 4.1 Circuit Simulations Noisy analog circuits can be simulated in SPICE or Cadence SpectreTM software via noisy voltage

Xyce

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomquist, Heidi K.; Fixel, Deborah A.; Fett, David Brian

The Xyce Parallel Electronic Simulator simulates electronic circuit behavior in DC, AC, HB, MPDE and transient mode using standard analog (DAE) and/or device (PDE) device models including several age and radiation aware devices. It supports a variety of computing platforms (both serial and parallel) computers. Lastly, it uses a variety of modern solution algorithms dynamic parallel load-balancing and iterative solvers.

Analog Computation by DNA Strand Displacement Circuits.

PubMed

Song, Tianqi; Garg, Sudhanshu; Mokhtar, Reem; Bui, Hieu; Reif, John

2016-08-19

DNA circuits have been widely used to develop biological computing devices because of their high programmability and versatility. Here, we propose an architecture for the systematic construction of DNA circuits for analog computation based on DNA strand displacement. The elementary gates in our architecture include addition, subtraction, and multiplication gates. The input and output of these gates are analog, which means that they are directly represented by the concentrations of the input and output DNA strands, respectively, without requiring a threshold for converting to Boolean signals. We provide detailed domain designs and kinetic simulations of the gates to demonstrate their expected performance. On the basis of these gates, we describe how DNA circuits to compute polynomial functions of inputs can be built. Using Taylor Series and Newton Iteration methods, functions beyond the scope of polynomials can also be computed by DNA circuits built upon our architecture.

The Energy-Environment Simulator as a Classroom Aid.

ERIC Educational Resources Information Center

Sell, Nancy J.; Van Koevering, Thomas E.

1981-01-01

Describes the use, availability, and flexibility of the Energy-Environment Simulator, a specially designed analog computer which simulates the real-world energy situation and which is programed with estimated United States and world supplies of energy sources and estimated United States energy demands. (MP)

Tomographic and analog 3-D simulations using NORA. [Non-Overlapping Redundant Image Array formed by multiple pinholes

NASA Technical Reports Server (NTRS)

Yin, L. I.; Trombka, J. I.; Bielefeld, M. J.; Seltzer, S. M.

1984-01-01

The results of two computer simulations demonstrate the feasibility of using the nonoverlapping redundant array (NORA) to form three-dimensional images of objects with X-rays. Pinholes admit the X-rays to nonoverlapping points on a detector. The object is reconstructed in the analog mode by optical correlation and in the digital mode by tomographic computations. Trials were run with a stick-figure pyramid and extended objects with out-of-focus backgrounds. Substitution of spherical optical lenses for the pinholes increased the light transmission sufficiently that objects could be easily viewed in a dark room. Out-of-focus aberrations in tomographic reconstruction could be eliminated using Chang's (1976) algorithm.

Numerical Simulation Of Cutting Of Gear Teeth

NASA Technical Reports Server (NTRS)

Oswald, Fred B.; Huston, Ronald L.; Mavriplis, Dimitrios

1994-01-01

Shapes of gear teeth produced by gear cutters of specified shape simulated computationally, according to approach based on principles of differential geometry. Results of computer simulation displayed as computer graphics and/or used in analyses of design, manufacturing, and performance of gears. Applicable to both standard and non-standard gear-tooth forms. Accelerates and facilitates analysis of alternative designs of gears and cutters. Simulation extended to study generation of surfaces other than gears. Applied to cams, bearings, and surfaces of arbitrary rolling elements as well as to gears. Possible to develop analogous procedures for simulating manufacture of skin surfaces like automobile fenders, airfoils, and ship hulls.

Video signal processing system uses gated current mode switches to perform high speed multiplication and digital-to-analog conversion

NASA Technical Reports Server (NTRS)

Gilliland, M. G.; Rougelot, R. S.; Schumaker, R. A.

1966-01-01

Video signal processor uses special-purpose integrated circuits with nonsaturating current mode switching to accept texture and color information from a digital computer in a visual spaceflight simulator and to combine these, for display on color CRT with analog information concerning fading.

Performance evaluation of digital phase-locked loops for advanced deep space transponders

NASA Technical Reports Server (NTRS)

Nguyen, T. M.; Hinedi, S. M.; Yeh, H.-G.; Kyriacou, C.

1994-01-01

The performances of the digital phase-locked loops (DPLL's) for the advanced deep-space transponders (ADT's) are investigated. DPLL's considered in this article are derived from the analog phase-locked loop, which is currently employed by the NASA standard deep space transponder, using S-domain to Z-domain mapping techniques. Three mappings are used to develop digital approximations of the standard deep space analog phase-locked loop, namely the bilinear transformation (BT), impulse invariant transformation (IIT), and step invariant transformation (SIT) techniques. The performance in terms of the closed loop phase and magnitude responses, carrier tracking jitter, and response of the loop to the phase offset (the difference between in incoming phase and reference phase) is evaluated for each digital approximation. Theoretical results of the carrier tracking jitter for command-on and command-off cases are then validated by computer simulation. Both theoretical and computer simulation results show that at high sampling frequency, the DPLL's approximated by all three transformations have the same tracking jitter. However, at low sampling frequency, the digital approximation using BT outperforms the others. The minimum sampling frequency for adequate tracking performance is determined for each digital approximation of the analog loop. In addition, computer simulation shows that the DPLL developed by BT provides faster response to the phase offset than IIT and SIT.

Programs for Testing an SSME-Monitoring System

NASA Technical Reports Server (NTRS)

Lang, Andre; Cecil, Jimmie; Heusinger, Ralph; Freestone, Kathleen; Blue, Lisa; Wilkerson, DeLisa; McMahon, Leigh Anne; Hall, Richard B.; Varnavas, Kosta; Smith, Keary;

The Energy-Environment Simulator as a Classroom Aid.

ERIC Educational Resources Information Center

Sell, Nancy J.; Van Koevering, Thomas E.

1981-01-01

Energy-Environment Simulators, provided by the U.S. Department of Energy, can be used to help individuals experience the effects of unbridled energy consumption for the next century on a national or worldwide scale. The simulator described is a specially designed analog computer which models the real-world energy situation. (MP)

Generalized simulation technique for turbojet engine system analysis

NASA Technical Reports Server (NTRS)

Seldner, K.; Mihaloew, J. R.; Blaha, R. J.

1972-01-01

A nonlinear analog simulation of a turbojet engine was developed. The purpose of the study was to establish simulation techniques applicable to propulsion system dynamics and controls research. A schematic model was derived from a physical description of a J85-13 turbojet engine. Basic conservation equations were applied to each component along with their individual performance characteristics to derive a mathematical representation. The simulation was mechanized on an analog computer. The simulation was verified in both steady-state and dynamic modes by comparing analytical results with experimental data obtained from tests performed at the Lewis Research Center with a J85-13 engine. In addition, comparison was also made with performance data obtained from the engine manufacturer. The comparisons established the validity of the simulation technique.

Comparison of digital controllers used in magnetic suspension and balance systems

NASA Technical Reports Server (NTRS)

Kilgore, William A.

1990-01-01

Dynamic systems that were once controlled by analog circuits are now controlled by digital computers. Presented is a comparison of the digital controllers presently used with magnetic suspension and balance systems. The overall responses of the systems are compared using a computer simulation of the magnetic suspension and balance system and the digital controllers. The comparisons include responses to both simulated force and position inputs. A preferred digital controller is determined from the simulated responses.

Analysis of Experimental Sea-level Transient Data and Analog Method of Obtaining Altitude Response for Turbine-propeller Engine with Relay-type Speed Control

NASA Technical Reports Server (NTRS)

Vasu, George; Pack, George J

1951-01-01

Correlation has been established between transient engine and control data obtained experimentally and data obtained by simulating the engine and control with an analog computer. This correlation was established at sea-level conditions for a turbine-propeller engine with a relay-type speed control. The behavior of the controlled engine at altitudes of 20,000 and 35,000 feet was determined with an analog computer using the altitude pressure and temperature generalization factors to calculate the new engine constants for these altitudes. Because the engine response varies considerably at altitude some type of compensation appears desirable and four methods of compensation are discussed.

Digital-computer normal shock position and restart control of a Mach 2.5 axisymmetric mixed-compression inlet

NASA Technical Reports Server (NTRS)

Neiner, G. H.; Cole, G. L.; Arpasi, D. J.

1972-01-01

Digital computer control of a mixed-compression inlet is discussed. The inlet was terminated with a choked orifice at the compressor face station to dynamically simulate a turbojet engine. Inlet diffuser exit airflow disturbances were used. A digital version of a previously tested analog control system was used for both normal shock and restart control. Digital computer algorithms were derived using z-transform and finite difference methods. Using a sample rate of 1000 samples per second, the digital normal shock and restart controls essentially duplicated the inlet analog computer control results. At a sample rate of 100 samples per second, the control system performed adequately but was less stable.

Enhanced Master Controller Unit Tester

NASA Technical Reports Server (NTRS)

Benson, Patricia; Johnson, Yvette; Johnson, Brian; Williams, Philip; Burton, Geoffrey; McCoy, Anthony

2007-01-01

The Enhanced Master Controller Unit Tester (EMUT) software is a tool for development and testing of software for a master controller (MC) flight computer. The primary function of the EMUT software is to simulate interfaces between the MC computer and external analog and digital circuitry (including other computers) in a rack of equipment to be used in scientific experiments. The simulations span the range of nominal, off-nominal, and erroneous operational conditions, enabling the testing of MC software before all the equipment becomes available.

Fluid-line math model

NASA Technical Reports Server (NTRS)

Kandelman, A.; Nelson, D. J.

1977-01-01

Simplified mathematical model simulates large hydraulic systems on either analog or digital computers. Models of pumps, servoactuators, reservoirs, accumulators, and valves are connected generating systems containing six hundred elements.

Designing artificial enzymes from scratch: Experimental study and mesoscale simulation

NASA Astrophysics Data System (ADS)

Komarov, Pavel V.; Zaborina, Olga E.; Klimova, Tamara P.; Lozinsky, Vladimir I.; Khalatur, Pavel G.; Khokhlov, Alexey R.

2016-09-01

We present a new concept for designing biomimetic analogs of enzymatic proteins; these analogs are based on the synthetic protein-like copolymers. α-Chymotrypsin is used as a prototype of the artificial catalyst. Our experimental study shows that in the course of free radical copolymerization of hydrophobic and hydrophilic monomers the target globular nanostructures of a "core-shell" morphology appear in a selective solvent. Using a mesoscale computer simulation, we show that the protein-like globules can have a large number of catalytic centers located at the hydrophobic core/hydrophilic shell interface.

Physics Notes.

ERIC Educational Resources Information Center

School Science Review, 1983

1983-01-01

Discusses the Rugby clock as a source of project material, use of ZX81 for experimental science, computer dice analog, oil recovery from reservoirs, and computer simulation of Thompson's experiment for determining e/m for an electron. Activities/procedures are provided when applicable. Also presents questions (and answers) related to time-coded…

A Computationally Efficient Visual Saliency Algorithm Suitable for an Analog CMOS Implementation.

PubMed

D'Angelo, Robert; Wood, Richard; Lowry, Nathan; Freifeld, Geremy; Huang, Haiyao; Salthouse, Christopher D; Hollosi, Brent; Muresan, Matthew; Uy, Wes; Tran, Nhut; Chery, Armand; Poppe, Dorothy C; Sonkusale, Sameer

2018-06-27

Computer vision algorithms are often limited in their application by the large amount of data that must be processed. Mammalian vision systems mitigate this high bandwidth requirement by prioritizing certain regions of the visual field with neural circuits that select the most salient regions. This work introduces a novel and computationally efficient visual saliency algorithm for performing this neuromorphic attention-based data reduction. The proposed algorithm has the added advantage that it is compatible with an analog CMOS design while still achieving comparable performance to existing state-of-the-art saliency algorithms. This compatibility allows for direct integration with the analog-to-digital conversion circuitry present in CMOS image sensors. This integration leads to power savings in the converter by quantizing only the salient pixels. Further system-level power savings are gained by reducing the amount of data that must be transmitted and processed in the digital domain. The analog CMOS compatible formulation relies on a pulse width (i.e., time mode) encoding of the pixel data that is compatible with pulse-mode imagers and slope based converters often used in imager designs. This letter begins by discussing this time-mode encoding for implementing neuromorphic architectures. Next, the proposed algorithm is derived. Hardware-oriented optimizations and modifications to this algorithm are proposed and discussed. Next, a metric for quantifying saliency accuracy is proposed, and simulation results of this metric are presented. Finally, an analog synthesis approach for a time-mode architecture is outlined, and postsynthesis transistor-level simulations that demonstrate functionality of an implementation in a modern CMOS process are discussed.

Optimal mapping of irregular finite element domains to parallel processors

NASA Technical Reports Server (NTRS)

Flower, J.; Otto, S.; Salama, M.

1987-01-01

Mapping the solution domain of n-finite elements into N-subdomains that may be processed in parallel by N-processors is an optimal one if the subdomain decomposition results in a well-balanced workload distribution among the processors. The problem is discussed in the context of irregular finite element domains as an important aspect of the efficient utilization of the capabilities of emerging multiprocessor computers. Finding the optimal mapping is an intractable combinatorial optimization problem, for which a satisfactory approximate solution is obtained here by analogy to a method used in statistical mechanics for simulating the annealing process in solids. The simulated annealing analogy and algorithm are described, and numerical results are given for mapping an irregular two-dimensional finite element domain containing a singularity onto the Hypercube computer.

Analog Computer-Aided Detection (CAD) information can be more effective than binary marks.

PubMed

Cunningham, Corbin A; Drew, Trafton; Wolfe, Jeremy M

2017-02-01

In socially important visual search tasks, such as baggage screening and diagnostic radiology, experts miss more targets than is desirable. Computer-aided detection (CAD) programs have been developed specifically to improve performance in these professional search tasks. For example, in breast cancer screening, many CAD systems are capable of detecting approximately 90% of breast cancer, with approximately 0.5 false-positive detections per image. Nevertheless, benefits of CAD in clinical settings tend to be small (Birdwell, 2009) or even absent (Meziane et al., 2011; Philpotts, 2009). The marks made by a CAD system can be "binary," giving the same signal to any location where the signal is above some threshold. Alternatively, a CAD system presents an analog signal that reflects strength of the signal at a location. In the experiments reported, we compare analog and binary CAD presentations using nonexpert observers and artificial stimuli defined by two noisy signals: a visible color signal and an "invisible" signal that informed our simulated CAD system. We found that analog CAD generally yielded better overall performance than binary CAD. The analog benefit is similar at high and low target prevalence. Our data suggest that the form of the CAD signal can directly influence performance. Analog CAD may allow the computer to be more helpful to the searcher.

Noise studies of communication systems using the SYSTID computer aided analysis program

NASA Technical Reports Server (NTRS)

Tranter, W. H.; Dawson, C. T.

1973-01-01

SYSTID computer aided design is a simple program for simulating data systems and communication links. A trial of the efficiency of the method was carried out by simulating a linear analog communication system to determine its noise performance and by comparing the SYSTID result with the result arrived at by theoretical calculation. It is shown that the SYSTID program is readily applicable to the analysis of these types of systems.

Methods of sound simulation and applications in flight simulators

NASA Technical Reports Server (NTRS)

Gaertner, K. P.

1980-01-01

An overview of methods for electronically synthesizing sounds is presented. A given amount of hardware and computer capacity places an upper limit on the degree and fidelity of realism of sound simulation which is attainable. Good sound realism for aircraft simulators can be especially expensive because of the complexity of flight sounds and their changing patterns through time. Nevertheless, the flight simulator developed at the Research Institute for Human Engineering, West Germany, shows that it is possible to design an inexpensive sound simulator with the required acoustic properties using analog computer elements. The characteristics of the sub-sound elements produced by this sound simulator for take-off, cruise and approach are discussed.

Memristor-Based Analog Computation and Neural Network Classification with a Dot Product Engine.

PubMed

Hu, Miao; Graves, Catherine E; Li, Can; Li, Yunning; Ge, Ning; Montgomery, Eric; Davila, Noraica; Jiang, Hao; Williams, R Stanley; Yang, J Joshua; Xia, Qiangfei; Strachan, John Paul

2018-03-01

Using memristor crossbar arrays to accelerate computations is a promising approach to efficiently implement algorithms in deep neural networks. Early demonstrations, however, are limited to simulations or small-scale problems primarily due to materials and device challenges that limit the size of the memristor crossbar arrays that can be reliably programmed to stable and analog values, which is the focus of the current work. High-precision analog tuning and control of memristor cells across a 128 × 64 array is demonstrated, and the resulting vector matrix multiplication (VMM) computing precision is evaluated. Single-layer neural network inference is performed in these arrays, and the performance compared to a digital approach is assessed. Memristor computing system used here reaches a VMM accuracy equivalent of 6 bits, and an 89.9% recognition accuracy is achieved for the 10k MNIST handwritten digit test set. Forecasts show that with integrated (on chip) and scaled memristors, a computational efficiency greater than 100 trillion operations per second per Watt is possible. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Acoustic analog computing based on a reflective metasurface with decoupled modulation of phase and amplitude

NASA Astrophysics Data System (ADS)

Zuo, Shu-Yu; Tian, Ye; Wei, Qi; Cheng, Ying; Liu, Xiao-Jun

2018-03-01

The use of metasurfaces has allowed the provision of a variety of functionalities by ultrathin structures, paving the way toward novel highly compact analog computing devices. Here, we conceptually realize analog computing using an acoustic reflective computational metasurface (RCM) that can independently manipulate the reflection phase and amplitude of an incident acoustic signal. This RCM is composed of coating unit cells and perforated panels, where the first can tune the transmission phase within the full range of 2π and the second can adjust the reflection amplitude in the range of 0-1. We show that this RCM can achieve arbitrary reflection phase and amplitude and can be used to realize a unique linear spatially invariant transfer function. Using the spatial Fourier transform (FT), an acoustic analog computing (AAC) system is proposed based on the RCM together with a focusing lens. Based on numerical simulations, we demonstrate that this AAC system can perform mathematical operations such as spatial differentiation, integration, and convolution on an incident acoustic signal. The proposed system has low complexity and reduced size because the RCM is able to individually adjust the reflection phase and amplitude and because only one block is involved in performing the spatial FT. Our work may offer a practical, efficient, and flexible approach to the design of compact devices for acoustic computing applications, signal processing, equation solving, and acoustic wave manipulations.

Electrostatic Solvation Free Energy of Amino Acid Side Chain Analogs: Implications for the Validity of Electrostatic Linear Response in Water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Bin; Pettitt, Bernard M.

Electrostatic free energies of solvation for 15 neutral amino acid side chain analogs are computed. We compare three methods of varying computational complexity and accuracy for three force fields: free energy simulations, Poisson-Boltzmann (PB), and linear response approximation (LRA) using AMBER, CHARMM, and OPLSAA force fields. We find that deviations from simulation start at low charges for solutes. The approximate PB and LRA produce an overestimation of electrostatic solvation free energies for most of molecules studied here. These deviations are remarkably systematic. The variations among force fields are almost as large as the variations found among methods. Our study confirmsmore » that success of the approximate methods for electrostatic solvation free energies comes from their ability to evaluate free energy differences accurately.« less

COED Transactions, Vol. X, No. 7 & 8, July/August 1978. Bridging Theory and Reality: Analog Simulation as an Aid to Heuristic Understanding.

ERIC Educational Resources Information Center

Marcovitz, Alan B., Ed.

A particularly difficult area for many engineering students is the approximate nature of the relation between models and physical systems. This is notably true when the models consist of differential equations. An approach applied to this problem has been to use analog computers to assist in portraying the output of a model as it is progressively…

Lie group model neuromorphic geometric engine for real-time terrain reconstruction from stereoscopic aerial photos

NASA Astrophysics Data System (ADS)

Tsao, Thomas R.; Tsao, Doris

1997-04-01

In the 1980's, neurobiologist suggested a simple mechanism in primate visual cortex for maintaining a stable and invariant representation of a moving object. The receptive field of visual neurons has real-time transforms in response to motion, to maintain a stable representation. When the visual stimulus is changed due to motion, the geometric transform of the stimulus triggers a dual transform of the receptive field. This dual transform in the receptive fields compensates geometric variation in the stimulus. This process can be modelled using a Lie group method. The massive array of affine parameter sensing circuits will function as a smart sensor tightly coupled to the passive imaging sensor (retina). Neural geometric engine is a neuromorphic computing device simulating our Lie group model of spatial perception of primate's primal visual cortex. We have developed the computer simulation and experimented on realistic and synthetic image data, and performed a preliminary research of using analog VLSI technology for implementation of the neural geometric engine. We have benchmark tested on DMA's terrain data with their result and have built an analog integrated circuit to verify the computational structure of the engine. When fully implemented on ANALOG VLSI chip, we will be able to accurately reconstruct a 3D terrain surface in real-time from stereoscopic imagery.

Optimization behavior of brainstem respiratory neurons. A cerebral neural network model.

PubMed

Poon, C S

1991-01-01

A recent model of respiratory control suggested that the steady-state respiratory responses to CO2 and exercise may be governed by an optimal control law in the brainstem respiratory neurons. It was not certain, however, whether such complex optimization behavior could be accomplished by a realistic biological neural network. To test this hypothesis, we developed a hybrid computer-neural model in which the dynamics of the lung, brain and other tissue compartments were simulated on a digital computer. Mimicking the "controller" was a human subject who pedalled on a bicycle with varying speed (analog of ventilatory output) with a view to minimize an analog signal of the total cost of breathing (chemical and mechanical) which was computed interactively and displayed on an oscilloscope. In this manner, the visuomotor cortex served as a proxy (homolog) of the brainstem respiratory neurons in the model. Results in 4 subjects showed a linear steady-state ventilatory CO2 response to arterial PCO2 during simulated CO2 inhalation and a nearly isocapnic steady-state response during simulated exercise. Thus, neural optimization is a plausible mechanism for respiratory control during exercise and can be achieved by a neural network with cognitive computational ability without the need for an exercise stimulus.

Analog Computer-Aided Detection (CAD) information can be more effective than binary marks

PubMed Central

Cunningham, Corbin A.; Drew, Trafton; Wolfe, Jeremy M.

2017-01-01

In socially important visual search tasks such as baggage screening and diagnostic radiology, experts miss more targets than is desirable. Computer Aided Detection (CAD) programs have been developed specifically to help improve performance in these professional search tasks. For example, in breast cancer screening, many CAD systems are capable of detecting approximately 90% of breast cancer, with approximately 0.5 false positive detections per image. Nevertheless, benefits of CAD in clinical settings tend to be small (Birdwell, 2009) or even absent (Meziane et al., 2011; Philpotts, 2009). The marks made by a CAD system can be “Binary”, giving the same signal to any location where the signal is above some threshold. Alternatively, a CAD system present an Analog signal that reflected strength of the signal at a location. In the experiments reported here, we compare analog and binary CAD presentations using non-expert observers and artificial stimuli defined by two noisy signals: a visible color signal and an "invisible" signal that informed our simulated CAD system. We found that analog CAD generally yielded better overall performance than binary CAD. The analog benefit is similar at high and low target prevalence. Our data suggest that the form of the CAD signal can directly influence performance. Analog CAD may allow the computer to be more helpful to the searcher. PMID:27928658

Flight instrument and telemetry response and its inversion

NASA Technical Reports Server (NTRS)

Weinberger, M. R.

1971-01-01

Mathematical models of rate gyros, servo accelerometers, pressure transducers, and telemetry systems were derived and their parameters were obtained from laboratory tests. Analog computer simulations were used extensively for verification of the validity for fast and large input signals. An optimal inversion method was derived to reconstruct input signals from noisy output signals and a computer program was prepared.

50 Years of Army Computing From ENIAC to MSRC

DTIC Science & Technology

2000-09-01

processing capability. The scientifi c visualization program was started in 1984 to provide tools and expertise to help researchers graphically...and materials, forces modeling, nanoelectronics, electromagnetics and acoustics, signal image processing , and simulation and modeling. The ARL...mechanical and electrical calculating equipment, punch card data processing equipment, analog computers, and early digital machines. Before beginning, we

Impaired Oral Reading in Two Atypical Dyslexics: A Comparison with a Computational Lexical-Analogy Model

ERIC Educational Resources Information Center

Marchand, Y.; Friedman, R.B.

2005-01-01

A computational model of reading was developed based upon the notion that the structural relationship between orthography and phonology is of greater importance than the dimension of semantics for the reading aloud of single words. Degradation of this model successfully simulated the reading performance of two patients with atypical acquired…

An analog retina model for detecting dim moving objects against a bright moving background

NASA Technical Reports Server (NTRS)

Searfus, R. M.; Colvin, M. E.; Eeckman, F. H.; Teeters, J. L.; Axelrod, T. S.

1991-01-01

We are interested in applications that require the ability to track a dim target against a bright, moving background. Since the target signal will be less than or comparable to the variations in the background signal intensity, sophisticated techniques must be employed to detect the target. We present an analog retina model that adapts to the motion of the background in order to enhance targets that have a velocity difference with respect to the background. Computer simulation results and our preliminary concept of an analog 'Z' focal plane implementation are also presented.

Broadening the interface bandwidth in simulation based training

NASA Technical Reports Server (NTRS)

Somers, Larry E.

1989-01-01

Currently most computer based simulations rely exclusively on computer generated graphics to create the simulation. When training is involved, the method almost exclusively used to display information to the learner is text displayed on the cathode ray tube. MICROEXPERT Systems is concentrating on broadening the communications bandwidth between the computer and user by employing a novel approach to video image storage combined with sound and voice output. An expert system is used to combine and control the presentation of analog video, sound, and voice output with computer based graphics and text. Researchers are currently involved in the development of several graphics based user interfaces for NASA, the U.S. Army, and the U.S. Navy. Here, the focus is on the human factors considerations, software modules, and hardware components being used to develop these interfaces.

Analog Design for Digital Deployment of a Serious Leadership Game

NASA Technical Reports Server (NTRS)

Maxwell, Nicholas; Lang, Tristan; Herman, Jeffrey L.; Phares, Richard

2012-01-01

This paper presents the design, development, and user testing of a leadership development simulation. The authors share lessons learned from using a design process for a board game to allow for quick and inexpensive revision cycles during the development of a serious leadership development game. The goal of this leadership simulation is to accelerate the development of leadership capacity in high-potential mid-level managers (GS-15 level) in a federal government agency. Simulation design included a mixed-method needs analysis, using both quantitative and qualitative approaches to determine organizational leadership needs. Eight design iterations were conducted, including three user testing phases. Three re-design iterations followed initial development, enabling game testing as part of comprehensive instructional events. Subsequent design, development and testing processes targeted digital application to a computer- and tablet-based environment. Recommendations include pros and cons of development and learner testing of an initial analog simulation prior to full digital simulation development.

First-Order-hold interpolation digital-to-analog converter with application to aircraft simulation

NASA Technical Reports Server (NTRS)

Cleveland, W. B.

1976-01-01

Those who design piloted aircraft simulations must contend with the finite size and speed of the available digital computer and the requirement for simulation reality. With a fixed computational plant, the more complex the model, the more computing cycle time is required. While increasing the cycle time may not degrade the fidelity of the simulated aircraft dynamics, the larger steps in the pilot cue feedback variables (such as the visual scene cues), may be disconcerting to the pilot. The first-order-hold interpolation (FOHI) digital-to-analog converter (DAC) is presented as a device which offers smooth output, regardless of cycle time. The Laplace transforms of these three conversion types are developed and their frequency response characteristics and output smoothness are compared. The FOHI DAC exhibits a pure one-cycle delay. Whenever the FOHI DAC input comes from a second-order (or higher) system, a simple computer software technique can be used to compensate for the DAC phase lag. When so compensated, the FOHI DAC has (1) an output signal that is very smooth, (2) a flat frequency response in frequency ranges of interest, and (3) no phase error. When the input comes from a first-order system, software compensation may cause the FOHI DAC to perform as an FOHE DAC, which, although its output is not as smooth as that of the FOHI DAC, has a smoother output than that of the ZOH DAC.

Early differentiation of the Moon: Experimental and modeling studies

NASA Technical Reports Server (NTRS)

Longhi, J.

1986-01-01

Major accomplishments include the mapping out of liquidus boundaries of lunar and meteoritic basalts at low pressure; the refinement of computer models that simulate low pressure fractional crystallization; the development of a computer model to calculate high pressure partial melting of the lunar and Martian interiors; and the proposal of a hypothesis of early lunar differentiation based upon terrestrial analogs.

Simulating Soft Shadows with Graphics Hardware,

DTIC Science & Technology

1997-01-15

This radiance texture is analogous to the mesh of radiosity values computed in a radiosity algorithm. Unlike a radiosity algorithm, however, our...discretely. Several researchers have explored continuous visibility methods for soft shadow computation and radiosity mesh generation. With this approach...times of several seconds [9]. Most radiosity methods discretize each surface into a mesh of elements and then use discrete methods such as ray

Noise in Neuronal and Electronic Circuits: A General Modeling Framework and Non-Monte Carlo Simulation Techniques.

PubMed

Kilinc, Deniz; Demir, Alper

2017-08-01

The brain is extremely energy efficient and remarkably robust in what it does despite the considerable variability and noise caused by the stochastic mechanisms in neurons and synapses. Computational modeling is a powerful tool that can help us gain insight into this important aspect of brain mechanism. A deep understanding and computational design tools can help develop robust neuromorphic electronic circuits and hybrid neuroelectronic systems. In this paper, we present a general modeling framework for biological neuronal circuits that systematically captures the nonstationary stochastic behavior of ion channels and synaptic processes. In this framework, fine-grained, discrete-state, continuous-time Markov chain models of both ion channels and synaptic processes are treated in a unified manner. Our modeling framework features a mechanism for the automatic generation of the corresponding coarse-grained, continuous-state, continuous-time stochastic differential equation models for neuronal variability and noise. Furthermore, we repurpose non-Monte Carlo noise analysis techniques, which were previously developed for analog electronic circuits, for the stochastic characterization of neuronal circuits both in time and frequency domain. We verify that the fast non-Monte Carlo analysis methods produce results with the same accuracy as computationally expensive Monte Carlo simulations. We have implemented the proposed techniques in a prototype simulator, where both biological neuronal and analog electronic circuits can be simulated together in a coupled manner.

Computation of the sound generated by isotropic turbulence

NASA Technical Reports Server (NTRS)

Sarkar, S.; Hussaini, M. Y.

1993-01-01

The acoustic radiation from isotropic turbulence is computed numerically. A hybrid direct numerical simulation approach which combines direct numerical simulation (DNS) of the turbulent flow with the Lighthill acoustic analogy is utilized. It is demonstrated that the hybrid DNS method is a feasible approach to the computation of sound generated by turbulent flows. The acoustic efficiency in the simulation of isotropic turbulence appears to be substantially less than that in subsonic jet experiments. The dominant frequency of the computed acoustic pressure is found to be somewhat larger than the dominant frequency of the energy-containing scales of motion. The acoustic power in the simulations is proportional to epsilon (M(sub t))(exp 5) where epsilon is the turbulent dissipation rate and M(sub t) is the turbulent Mach number. This is in agreement with the analytical result of Proudman (1952), but the constant of proportionality is smaller than the analytical result. Two different methods of computing the acoustic power from the DNS data bases yielded consistent results.

Water immersion and its computer simulation as analogs of weightlessness

NASA Technical Reports Server (NTRS)

Leonard, J. I.

1982-01-01

Experimental studies and computer simulations of water immersion are summarized and discussed with regard to their utility as analogs of weightlessness. Emphasis is placed on describing and interpreting the renal, endocrine, fluid, and circulatory changes that take place during immersion. A mathematical model, based on concepts of fluid volume regulation, is shown to be well suited to simulate the dynamic responses to water immersion. Further, it is shown that such a model provides a means to study specific mechanisms and pathways involved in the immersion response. A number of hypotheses are evaluated with the model related to the effects of dehydration, venous pressure disturbances, the control of ADH, and changes in plasma-interstitial volume. By inference, it is suggested that most of the model's responses to water immersion are plausible predictions of the acute changes expected, but not yet measured, during space flight. One important prediction of the model is that previous attempts to measure a diuresis during space flight failed because astronauts may have been dehydrated and urine samples were pooled over 24-hour periods.

An investigation of potential applications of OP-SAPS: Operational sampled analog processors

NASA Technical Reports Server (NTRS)

Parrish, E. A.; Mcvey, E. S.

1976-01-01

The impact of charge-coupled device (CCD) processors on future instrumentation was investigated. The CCD devices studied process sampled analog data and are referred to as OP-SAPS - operational sampled analog processors. Preliminary studies into various architectural configurations for systems composed of OP-SAPS show that they have potential in such diverse applications as pattern recognition and automatic control. It appears probable that OP-SAPS may be used to construct computing structures which can serve as special peripherals to large-scale computer complexes used in real time flight simulation. The research was limited to the following benchmark programs: (1) face recognition, (2) voice command and control, (3) terrain classification, and (4) terrain identification. A small amount of effort was spent on examining a method by which OP-SAPS may be used to decrease the limiting ground sampling distance encountered in remote sensing from satellites.

Can one trust quantum simulators?

PubMed

Hauke, Philipp; Cucchietti, Fernando M; Tagliacozzo, Luca; Deutsch, Ivan; Lewenstein, Maciej

2012-08-01

Various fundamental phenomena of strongly correlated quantum systems such as high-T(c) superconductivity, the fractional quantum-Hall effect and quark confinement are still awaiting a universally accepted explanation. The main obstacle is the computational complexity of solving even the most simplified theoretical models which are designed to capture the relevant quantum correlations of the many-body system of interest. In his seminal 1982 paper (Feynman 1982 Int. J. Theor. Phys. 21 467), Richard Feynman suggested that such models might be solved by 'simulation' with a new type of computer whose constituent parts are effectively governed by a desired quantum many-body dynamics. Measurements on this engineered machine, now known as a 'quantum simulator,' would reveal some unknown or difficult to compute properties of a model of interest. We argue that a useful quantum simulator must satisfy four conditions: relevance, controllability, reliability and efficiency. We review the current state of the art of digital and analog quantum simulators. Whereas so far the majority of the focus, both theoretically and experimentally, has been on controllability of relevant models, we emphasize here the need for a careful analysis of reliability and efficiency in the presence of imperfections. We discuss how disorder and noise can impact these conditions, and illustrate our concerns with novel numerical simulations of a paradigmatic example: a disordered quantum spin chain governed by the Ising model in a transverse magnetic field. We find that disorder can decrease the reliability of an analog quantum simulator of this model, although large errors in local observables are introduced only for strong levels of disorder. We conclude that the answer to the question 'Can we trust quantum simulators?' is … to some extent.

Design and Analysis of Compact DNA Strand Displacement Circuits for Analog Computation Using Autocatalytic Amplifiers.

PubMed

Song, Tianqi; Garg, Sudhanshu; Mokhtar, Reem; Bui, Hieu; Reif, John

2018-01-19

A main goal in DNA computing is to build DNA circuits to compute designated functions using a minimal number of DNA strands. Here, we propose a novel architecture to build compact DNA strand displacement circuits to compute a broad scope of functions in an analog fashion. A circuit by this architecture is composed of three autocatalytic amplifiers, and the amplifiers interact to perform computation. We show DNA circuits to compute functions sqrt(x), ln(x) and exp(x) for x in tunable ranges with simulation results. A key innovation in our architecture, inspired by Napier's use of logarithm transforms to compute square roots on a slide rule, is to make use of autocatalytic amplifiers to do logarithmic and exponential transforms in concentration and time. In particular, we convert from the input that is encoded by the initial concentration of the input DNA strand, to time, and then back again to the output encoded by the concentration of the output DNA strand at equilibrium. This combined use of strand-concentration and time encoding of computational values may have impact on other forms of molecular computation.

Digital computer technique for setup and checkout of an analog computer

NASA Technical Reports Server (NTRS)

Ambaruch, R.

1968-01-01

Computer program technique, called Analog Computer Check-Out Routine Digitally /ACCORD/, generates complete setup and checkout data for an analog computer. In addition, the correctness of the analog program implementation is validated.

Principles for Integrating Mars Analog Science, Operations, and Technology Research

NASA Technical Reports Server (NTRS)

Clancey, William J.

2003-01-01

During the Apollo program, the scientific community and NASA used terrestrial analog sites for understanding planetary features and for training astronauts to be scientists. Human factors studies (Harrison, Clearwater, & McKay 1991; Stuster 1996) have focused on the effects of isolation in extreme environments. More recently, with the advent of wireless computing, we have prototyped advanced EVA technologies for navigation, scheduling, and science data logging (Clancey 2002b; Clancey et al., in press). Combining these interests in a single expedition enables tremendous synergy and authenticity, as pioneered by Pascal Lee's Haughton-Mars Project (Lee 2001; Clancey 2000a) and the Mars Society s research stations on a crater rim on Devon Island in the High Canadian Arctic (Clancey 2000b; 2001b) and the Morrison Formation of southeast Utah (Clancey 2002a). Based on this experience, the following principles are proposed for conducting an integrated science, operations, and technology research program at analog sites: 1) Authentic work; 2) PI-based projects; 3) Unencumbered baseline studies; 4) Closed simulations; and 5) Observation and documentation. Following these principles, we have been integrating field science, operations research, and technology development at analog sites on Devon Island and in Utah over the past five years. Analytic methods include work practice simulation (Clancey 2002c; Sierhuis et a]., 2000a;b), by which the interaction of human behavior, facilities, geography, tools, and procedures are formalized in computer models. These models are then converted into the runtime EVA system we call mobile agents (Clancey 2002b; Clancey et al., in press). Furthermore, we have found that the Apollo Lunar Surface Journal (Jones, 1999) provides a vast repository or understanding astronaut and CapCom interactions, serving as a baseline for Mars operations and quickly highlighting opportunities for computer automation (Clancey, in press).

Mechanical Analog Approach to Parameter Estimation of Lateral Spacecraft Fuel Slosh

NASA Technical Reports Server (NTRS)

Chatman, Yadira; Gangadharan, Sathya; Schlee, Keith; Sudermann, James; Walker, Charles; Ristow, James; Hubert, Carl

2007-01-01

The nutation (wobble) of a spinning spacecraft in the presence of energy dissipation is a well-known problem in dynamics and is of particular concern for space missions. Even with modern computing systems, CFD type simulations are not fast enough to allow for large scale Monte Carlo analyses of spacecraft and launch vehicle dynamic behavior with slosh included. Simplified mechanical analogs for the slosh are preferred during the initial stages of design to reduce computational time and effort to evaluate the Nutation Time Constant (NTC). Analytic determination of the slosh analog parameters has met with mixed success and is made even more difficult by the introduction of propellant management devices such as elastomeric diaphragms. By subjecting full-sized fuel tanks with actual flight fuel loads to motion similar to that experienced in flight and measuring the forces experienced by the tanks, these parameters can be determined experimentally. Currently, the identification of the model parameters is a laborious trial-and-error process in which the hand-derived equations of motion for the mechanical analog are evaluated and their results compared with the experimental results. Of particular interest is the effect of diaphragms and bladders on the slosh dynamics and how best to model these devices. An experimental set-up is designed and built to include a diaphragm in the simulated spacecraft fuel tank subjected to lateral slosh. This research paper focuses on the parameter estimation of a SimMechanics model of the simulated spacecraft propellant tank with and without diaphragms using lateral fuel slosh experiments. Automating the parameter identification process will save time and thus allow earlier identification of potential vehicle problems.

Shock and vibration technology with applications to electrical systems

NASA Technical Reports Server (NTRS)

Eshleman, R. L.

1972-01-01

A survey is presented of shock and vibration technology for electrical systems developed by the aerospace programs. The shock environment is surveyed along with new techniques for modeling, computer simulation, damping, and response analysis. Design techniques based on the use of analog computers, shock spectra, optimization, and nonlinear isolation are discussed. Shock mounting of rotors for performance and survival, and vibration isolation techniques are reviewed.

Can one trust quantum simulators?

NASA Astrophysics Data System (ADS)

Hauke, Philipp; Cucchietti, Fernando M.; Tagliacozzo, Luca; Deutsch, Ivan; Lewenstein, Maciej

2012-08-01

Various fundamental phenomena of strongly correlated quantum systems such as high-Tc superconductivity, the fractional quantum-Hall effect and quark confinement are still awaiting a universally accepted explanation. The main obstacle is the computational complexity of solving even the most simplified theoretical models which are designed to capture the relevant quantum correlations of the many-body system of interest. In his seminal 1982 paper (Feynman 1982 Int. J. Theor. Phys. 21 467), Richard Feynman suggested that such models might be solved by ‘simulation’ with a new type of computer whose constituent parts are effectively governed by a desired quantum many-body dynamics. Measurements on this engineered machine, now known as a ‘quantum simulator,’ would reveal some unknown or difficult to compute properties of a model of interest. We argue that a useful quantum simulator must satisfy four conditions: relevance, controllability, reliability and efficiency. We review the current state of the art of digital and analog quantum simulators. Whereas so far the majority of the focus, both theoretically and experimentally, has been on controllability of relevant models, we emphasize here the need for a careful analysis of reliability and efficiency in the presence of imperfections. We discuss how disorder and noise can impact these conditions, and illustrate our concerns with novel numerical simulations of a paradigmatic example: a disordered quantum spin chain governed by the Ising model in a transverse magnetic field. We find that disorder can decrease the reliability of an analog quantum simulator of this model, although large errors in local observables are introduced only for strong levels of disorder. We conclude that the answer to the question ‘Can we trust quantum simulators?’ is … to some extent.

Using NCAR Yellowstone for PhotoVoltaic Power Forecasts with Artificial Neural Networks and an Analog Ensemble

NASA Astrophysics Data System (ADS)

Cervone, G.; Clemente-Harding, L.; Alessandrini, S.; Delle Monache, L.

2016-12-01

A methodology based on Artificial Neural Networks (ANN) and an Analog Ensemble (AnEn) is presented to generate 72-hour deterministic and probabilistic forecasts of power generated by photovoltaic (PV) power plants using input from a numerical weather prediction model and computed astronomical variables. ANN and AnEn are used individually and in combination to generate forecasts for three solar power plant located in Italy. The computational scalability of the proposed solution is tested using synthetic data simulating 4,450 PV power stations. The NCAR Yellowstone supercomputer is employed to test the parallel implementation of the proposed solution, ranging from 1 node (32 cores) to 4,450 nodes (141,140 cores). Results show that a combined AnEn + ANN solution yields best results, and that the proposed solution is well suited for massive scale computation.

Modeling and Parameter Estimation of Spacecraft Fuel Slosh with Diaphragms Using Pendulum Analogs

NASA Technical Reports Server (NTRS)

Chatman, Yadira; Gangadharan, Sathya; Schlee, Keith; Ristow, James; Suderman, James; Walker, Charles; Hubert, Carl

2007-01-01

Prediction and control of liquid slosh in moving containers is an important consideration in the design of spacecraft and launch vehicle control systems. Even with modern computing systems, CFD type simulations are not fast enough to allow for large scale Monte Carlo analyses of spacecraft and launch vehicle dynamic behavior with slosh included. It is still desirable to use some type of simplified mechanical analog for the slosh to shorten computation time. Analytic determination of the slosh analog parameters has met with mixed success and is made even more difficult by the introduction of propellant management devices such as elastomeric diaphragms. By subjecting full-sized fuel tanks with actual flight fuel loads to motion similar to that experienced in flight and measuring the forces experienced by the tanks, these parameters can be determined experimentally. Currently, the identification of the model parameters is a laborious trial-and-error process in which the hand-derived equations of motion for the mechanical analog are evaluated and their results compared with the experimental results. This paper will describe efforts by the university component of a team comprised of NASA's Launch Services Program, Embry Riddle Aeronautical University, Southwest Research Institute and Hubert Astronautics to improve the accuracy and efficiency of modeling techniques used to predict these types of motions. Of particular interest is the effect of diaphragms and bladders on the slosh dynamics and how best to model these devices. The previous research was an effort to automate the process of slosh model parameter identification using a MATLAB/SimMechanics-based computer simulation. These results are the first step in applying the same computer estimation to a full-size tank and vehicle propulsion system. The introduction of diaphragms to this experimental set-up will aid in a better and more complete prediction of fuel slosh characteristics and behavior. Automating the parameter identification process will save time and thus allow earlier identification of potential vehicle performance problems.

Compiling probabilistic, bio-inspired circuits on a field programmable analog array

PubMed Central

Marr, Bo; Hasler, Jennifer

2014-01-01

A field programmable analog array (FPAA) is presented as an energy and computational efficiency engine: a mixed mode processor for which functions can be compiled at significantly less energy costs using probabilistic computing circuits. More specifically, it will be shown that the core computation of any dynamical system can be computed on the FPAA at significantly less energy per operation than a digital implementation. A stochastic system that is dynamically controllable via voltage controlled amplifier and comparator thresholds is implemented, which computes Bernoulli random variables. From Bernoulli variables it is shown exponentially distributed random variables, and random variables of an arbitrary distribution can be computed. The Gillespie algorithm is simulated to show the utility of this system by calculating the trajectory of a biological system computed stochastically with this probabilistic hardware where over a 127X performance improvement over current software approaches is shown. The relevance of this approach is extended to any dynamical system. The initial circuits and ideas for this work were generated at the 2008 Telluride Neuromorphic Workshop. PMID:24847199

Computational approaches to computational aero-acoustics

NASA Technical Reports Server (NTRS)

Hardin, Jay C.

1996-01-01

The various techniques by which the goal of computational aeroacoustics (the calculation and noise prediction of a fluctuating fluid flow) may be achieved are reviewed. The governing equations for compressible fluid flow are presented. The direct numerical simulation approach is shown to be computationally intensive for high Reynolds number viscous flows. Therefore, other approaches, such as the acoustic analogy, vortex models and various perturbation techniques that aim to break the analysis into a viscous part and an acoustic part are presented. The choice of the approach is shown to be problem dependent.

Predictions of the physicochemical properties of amino acid side chain analogs using molecular simulation.

PubMed

Ahmed, Alauddin; Sandler, Stanley I

2016-03-07

A candidate drug compound is released for clinical trails (in vivo activity) only if its physicochemical properties meet desirable bioavailability and partitioning criteria. Amino acid side chain analogs play vital role in the functionalities of protein and peptides and as such are important in drug discovery. We demonstrate here that the predictions of solvation free energies in water, in 1-octanol, and self-solvation free energies computed using force field-based expanded ensemble molecular dynamics simulation provide good accuracy compared to existing empirical and semi-empirical methods. These solvation free energies are then, as shown here, used for the prediction of a wide range of physicochemical properties important in the assessment of bioavailability and partitioning of compounds. In particular, we consider here the vapor pressure, the solubility in both water and 1-octanol, and the air-water, air-octanol, and octanol-water partition coefficients of amino acid side chain analogs computed from the solvation free energies. The calculated solvation free energies using different force fields are compared against each other and with available experimental data. The protocol here can also be used for a newly designed drug and other molecules where force field parameters and charges are obtained from density functional theory.

An analog scrambler for speech based on sequential permutations in time and frequency

NASA Astrophysics Data System (ADS)

Cox, R. V.; Jayant, N. S.; McDermott, B. J.

Permutation of speech segments is an operation that is frequently used in the design of scramblers for analog speech privacy. In this paper, a sequential procedure for segment permutation is considered. This procedure can be extended to two dimensional permutation of time segments and frequency bands. By subjective testing it is shown that this combination gives a residual intelligibility for spoken digits of 20 percent with a delay of 256 ms. (A lower bound for this test would be 10 percent). The complexity of implementing such a system is considered and the issues of synchronization and channel equalization are addressed. The computer simulation results for the system using both real and simulated channels are examined.

Summary of Research 1998, Department of Electrical and Computer Engineering.

DTIC Science & Technology

1999-08-01

Channel Interference," Master’s Thesis, Naval Postgraduate School, December 1998. Erdogan , V, "Time Domain Simulation of MPSK Communications System...1998, several new user interface screens have been designed. Software for reading data from analog tape has been completed and interfaced to the

Analog hardware implementation of neocognitron networks

NASA Astrophysics Data System (ADS)

Inigo, Rafael M.; Bonde, Allen, Jr.; Holcombe, Bradford

1990-08-01

This paper deals with the analog implementation of neocognitron based neural networks. All of Fukushima''s and related work on the neocognitron is based on digital computer simulations. To fully take advantage of the power of this network paradigm an analog electronic approach is proposed. We first implemented a 6-by-6 sensor network with discrete analog components and fixed weights. The network was given weight values to recognize the characters U L and F. These characters are recognized regardless of their location on the sensor and with various levels of distortion and noise. The network performance has also shown an excellent correlation with software simulation results. Next we implemented a variable weight network which can be trained to recognize simple patterns by means of self-organization. The adaptable weights were implemented with PETs configured as voltage-controlled resistors. To implement a variable weight there must be some type of " memory" to store the weight value and hold it while the value is reinforced or incremented. Two methods were evaluated: an analog sample-hold circuit and a digital storage scheme using binary counters. The latter is preferable for VLSI implementation because it uses standard components and does not require the use of capacitors. The analog design and implementation of these small-scale networks demonstrates the feasibility of implementing more complicated ANNs in electronic hardware. The circuits developed can also be designed for VLSI implementation. 1.

Nuclear sensor signal processing circuit

DOEpatents

Kallenbach, Gene A [Bosque Farms, NM; Noda, Frank T [Albuquerque, NM; Mitchell, Dean J [Tijeras, NM; Etzkin, Joshua L [Albuquerque, NM

2007-02-20

An apparatus and method are disclosed for a compact and temperature-insensitive nuclear sensor that can be calibrated with a non-hazardous radioactive sample. The nuclear sensor includes a gamma ray sensor that generates tail pulses from radioactive samples. An analog conditioning circuit conditions the tail-pulse signals from the gamma ray sensor, and a tail-pulse simulator circuit generates a plurality of simulated tail-pulse signals. A computer system processes the tail pulses from the gamma ray sensor and the simulated tail pulses from the tail-pulse simulator circuit. The nuclear sensor is calibrated under the control of the computer. The offset is adjusted using the simulated tail pulses. Since the offset is set to zero or near zero, the sensor gain can be adjusted with a non-hazardous radioactive source such as, for example, naturally occurring radiation and potassium chloride.

Quantum Simulation of Tunneling in Small Systems

PubMed Central

Sornborger, Andrew T.

2012-01-01

A number of quantum algorithms have been performed on small quantum computers; these include Shor's prime factorization algorithm, error correction, Grover's search algorithm and a number of analog and digital quantum simulations. Because of the number of gates and qubits necessary, however, digital quantum particle simulations remain untested. A contributing factor to the system size required is the number of ancillary qubits needed to implement matrix exponentials of the potential operator. Here, we show that a set of tunneling problems may be investigated with no ancillary qubits and a cost of one single-qubit operator per time step for the potential evolution, eliminating at least half of the quantum gates required for the algorithm and more than that in the general case. Such simulations are within reach of current quantum computer architectures. PMID:22916333

Data and results of a laboratory investigation of microprocessor upset caused by simulated lightning-induced analog transients

NASA Technical Reports Server (NTRS)

Belcastro, C. M.

1984-01-01

Advanced composite aircraft designs include fault-tolerant computer-based digital control systems with thigh reliability requirements for adverse as well as optimum operating environments. Since aircraft penetrate intense electromagnetic fields during thunderstorms, onboard computer systems maya be subjected to field-induced transient voltages and currents resulting in functional error modes which are collectively referred to as digital system upset. A methodology was developed for assessing the upset susceptibility of a computer system onboard an aircraft flying through a lightning environment. Upset error modes in a general-purpose microprocessor were studied via tests which involved the random input of analog transients which model lightning-induced signals onto interface lines of an 8080-based microcomputer from which upset error data were recorded. The application of Markov modeling to upset susceptibility estimation is discussed and a stochastic model development.

Closed-Loop HIRF Experiments Performed on a Fault Tolerant Flight Control Computer

NASA Technical Reports Server (NTRS)

Belcastro, Celeste M.

1997-01-01

ABSTRACT Closed-loop HIRF experiments were performed on a fault tolerant flight control computer (FCC) at the NASA Langley Research Center. The FCC used in the experiments was a quad-redundant flight control computer executing B737 Autoland control laws. The FCC was placed in one of the mode-stirred reverberation chambers in the HIRF Laboratory and interfaced to a computer simulation of the B737 flight dynamics, engines, sensors, actuators, and atmosphere in the Closed-Loop Systems Laboratory. Disturbances to the aircraft associated with wind gusts and turbulence were simulated during tests. Electrical isolation between the FCC under test and the simulation computer was achieved via a fiber optic interface for the analog and discrete signals. Closed-loop operation of the FCC enabled flight dynamics and atmospheric disturbances affecting the aircraft to be represented during tests. Upset was induced in the FCC as a result of exposure to HIRF, and the effect of upset on the simulated flight of the aircraft was observed and recorded. This paper presents a description of these closed- loop HIRF experiments, upset data obtained from the FCC during these experiments, and closed-loop effects on the simulated flight of the aircraft.

Analog synthetic biology.

PubMed

Sarpeshkar, R

2014-03-28

We analyse the pros and cons of analog versus digital computation in living cells. Our analysis is based on fundamental laws of noise in gene and protein expression, which set limits on the energy, time, space, molecular count and part-count resources needed to compute at a given level of precision. We conclude that analog computation is significantly more efficient in its use of resources than deterministic digital computation even at relatively high levels of precision in the cell. Based on this analysis, we conclude that synthetic biology must use analog, collective analog, probabilistic and hybrid analog-digital computational approaches; otherwise, even relatively simple synthetic computations in cells such as addition will exceed energy and molecular-count budgets. We present schematics for efficiently representing analog DNA-protein computation in cells. Analog electronic flow in subthreshold transistors and analog molecular flux in chemical reactions obey Boltzmann exponential laws of thermodynamics and are described by astoundingly similar logarithmic electrochemical potentials. Therefore, cytomorphic circuits can help to map circuit designs between electronic and biochemical domains. We review recent work that uses positive-feedback linearization circuits to architect wide-dynamic-range logarithmic analog computation in Escherichia coli using three transcription factors, nearly two orders of magnitude more efficient in parts than prior digital implementations.

SiGe epitaxial memory for neuromorphic computing with reproducible high performance based on engineered dislocations

NASA Astrophysics Data System (ADS)

Choi, Shinhyun; Tan, Scott H.; Li, Zefan; Kim, Yunjo; Choi, Chanyeol; Chen, Pai-Yu; Yeon, Hanwool; Yu, Shimeng; Kim, Jeehwan

2018-01-01

Although several types of architecture combining memory cells and transistors have been used to demonstrate artificial synaptic arrays, they usually present limited scalability and high power consumption. Transistor-free analog switching devices may overcome these limitations, yet the typical switching process they rely on—formation of filaments in an amorphous medium—is not easily controlled and hence hampers the spatial and temporal reproducibility of the performance. Here, we demonstrate analog resistive switching devices that possess desired characteristics for neuromorphic computing networks with minimal performance variations using a single-crystalline SiGe layer epitaxially grown on Si as a switching medium. Such epitaxial random access memories utilize threading dislocations in SiGe to confine metal filaments in a defined, one-dimensional channel. This confinement results in drastically enhanced switching uniformity and long retention/high endurance with a high analog on/off ratio. Simulations using the MNIST handwritten recognition data set prove that epitaxial random access memories can operate with an online learning accuracy of 95.1%.

YF-12 cooperative airframe/propulsion control system program, volume 1

NASA Technical Reports Server (NTRS)

Anderson, D. L.; Connolly, G. F.; Mauro, F. M.; Reukauf, P. J.; Marks, R. (Editor)

1980-01-01

Several YF-12C airplane analog control systems were converted to a digital system. Included were the air data computer, autopilot, inlet control system, and autothrottle systems. This conversion was performed to allow assessment of digital technology applications to supersonic cruise aircraft. The digital system was composed of a digital computer and specialized interface unit. A large scale mathematical simulation of the airplane was used for integration testing and software checkout.

Studying Transonic Gases With a Hydraulic Analog

NASA Technical Reports Server (NTRS)

Wagner, W.; Lepore, F.

1986-01-01

Water table for hydraulic-flow research yields valuable information about gas flow at transonic speeds. Used to study fuel and oxidizer flow in high-pressure rocket engines. Method applied to gas flows in such equipment as furnaces, nozzles, and chemical lasers. Especially suitable when wall contours nonuniform, discontinuous, or unusually shaped. Wall shapes changed quickly for study and evaluated on spot. Method used instead of computer simulation when computer models unavailable, inaccurate, or costly to run.

Grand canonical ensemble Monte Carlo simulation of the dCpG/proflavine crystal hydrate.

PubMed

Resat, H; Mezei, M

1996-09-01

The grand canonical ensemble Monte Carlo molecular simulation method is used to investigate hydration patterns in the crystal hydrate structure of the dCpG/proflavine intercalated complex. The objective of this study is to show by example that the recently advocated grand canonical ensemble simulation is a computationally efficient method for determining the positions of the hydrating water molecules in protein and nucleic acid structures. A detailed molecular simulation convergence analysis and an analogous comparison of the theoretical results with experiments clearly show that the grand ensemble simulations can be far more advantageous than the comparable canonical ensemble simulations.

Research on application of intelligent computation based LUCC model in urbanization process

NASA Astrophysics Data System (ADS)

Chen, Zemin

2007-06-01

Global change study is an interdisciplinary and comprehensive research activity with international cooperation, arising in 1980s, with the largest scopes. The interaction between land use and cover change, as a research field with the crossing of natural science and social science, has become one of core subjects of global change study as well as the front edge and hot point of it. It is necessary to develop research on land use and cover change in urbanization process and build an analog model of urbanization to carry out description, simulation and analysis on dynamic behaviors in urban development change as well as to understand basic characteristics and rules of urbanization process. This has positive practical and theoretical significance for formulating urban and regional sustainable development strategy. The effect of urbanization on land use and cover change is mainly embodied in the change of quantity structure and space structure of urban space, and LUCC model in urbanization process has been an important research subject of urban geography and urban planning. In this paper, based upon previous research achievements, the writer systematically analyzes the research on land use/cover change in urbanization process with the theories of complexity science research and intelligent computation; builds a model for simulating and forecasting dynamic evolution of urban land use and cover change, on the basis of cellular automation model of complexity science research method and multi-agent theory; expands Markov model, traditional CA model and Agent model, introduces complexity science research theory and intelligent computation theory into LUCC research model to build intelligent computation-based LUCC model for analog research on land use and cover change in urbanization research, and performs case research. The concrete contents are as follows: 1. Complexity of LUCC research in urbanization process. Analyze urbanization process in combination with the contents of complexity science research and the conception of complexity feature to reveal the complexity features of LUCC research in urbanization process. Urban space system is a complex economic and cultural phenomenon as well as a social process, is the comprehensive characterization of urban society, economy and culture, and is a complex space system formed by society, economy and nature. It has dissipative structure characteristics, such as opening, dynamics, self-organization, non-balance etc. Traditional model cannot simulate these social, economic and natural driving forces of LUCC including main feedback relation from LUCC to driving force. 2. Establishment of Markov extended model of LUCC analog research in urbanization process. Firstly, use traditional LUCC research model to compute change speed of regional land use through calculating dynamic degree, exploitation degree and consumption degree of land use; use the theory of fuzzy set to rewrite the traditional Markov model, establish structure transfer matrix of land use, forecast and analyze dynamic change and development trend of land use, and present noticeable problems and corresponding measures in urbanization process according to research results. 3. Application of intelligent computation research and complexity science research method in LUCC analog model in urbanization process. On the basis of detailed elaboration of the theory and the model of LUCC research in urbanization process, analyze the problems of existing model used in LUCC research (namely, difficult to resolve many complexity phenomena in complex urban space system), discuss possible structure realization forms of LUCC analog research in combination with the theories of intelligent computation and complexity science research. Perform application analysis on BP artificial neural network and genetic algorithms of intelligent computation and CA model and MAS technology of complexity science research, discuss their theoretical origins and their own characteristics in detail, elaborate the feasibility of them in LUCC analog research, and bring forward improvement methods and measures on existing problems of this kind of model. 4. Establishment of LUCC analog model in urbanization process based on theories of intelligent computation and complexity science. Based on the research on abovementioned BP artificial neural network, genetic algorithms, CA model and multi-agent technology, put forward improvement methods and application assumption towards their expansion on geography, build LUCC analog model in urbanization process based on CA model and Agent model, realize the combination of learning mechanism of BP artificial neural network and fuzzy logic reasoning, express the regulation with explicit formula, and amend the initial regulation through self study; optimize network structure of LUCC analog model and methods and procedures of model parameters with genetic algorithms. In this paper, I introduce research theory and methods of complexity science into LUCC analog research and presents LUCC analog model based upon CA model and MAS theory. Meanwhile, I carry out corresponding expansion on traditional Markov model and introduce the theory of fuzzy set into data screening and parameter amendment of improved model to improve the accuracy and feasibility of Markov model in the research on land use/cover change.

A performance evaluation postprocessor for computer-aided design and analysis of communication systems

NASA Technical Reports Server (NTRS)

Tranter, W. H.

1979-01-01

A technique for estimating the signal-to-noise ratio at a point in a digital simulation of a communication system is described; the technique is essentially a digital realization of a technique proposed by Shepertycki (1964) for the evaluation of analog communication systems. Signals having lowpass or bandpass spectra may be used. Simulation results show the technique to be accurate over a wide range of signal-to-noise ratios.

Method and apparatus for transfer function simulator for testing complex systems

NASA Technical Reports Server (NTRS)

Kavaya, M. J. (Inventor)

1985-01-01

A method and apparatus for testing the operation of a complex stabilization circuit in a closed loop system is presented. The method is comprised of a programmed analog or digital computing system for implementing the transfer function of a load thereby providing a predictable load. The digital computing system employs a table stored in a microprocessor in which precomputed values of the load transfer function are stored for values of input signal from the stabilization circuit over the range of interest. This technique may be used not only for isolating faults in the stabilization circuit, but also for analyzing a fault in a faulty load by so varying parameters of the computing system as to simulate operation of the actual load with the fault.

Analog synthetic biology

PubMed Central

Sarpeshkar, R.

2014-01-01

We analyse the pros and cons of analog versus digital computation in living cells. Our analysis is based on fundamental laws of noise in gene and protein expression, which set limits on the energy, time, space, molecular count and part-count resources needed to compute at a given level of precision. We conclude that analog computation is significantly more efficient in its use of resources than deterministic digital computation even at relatively high levels of precision in the cell. Based on this analysis, we conclude that synthetic biology must use analog, collective analog, probabilistic and hybrid analog–digital computational approaches; otherwise, even relatively simple synthetic computations in cells such as addition will exceed energy and molecular-count budgets. We present schematics for efficiently representing analog DNA–protein computation in cells. Analog electronic flow in subthreshold transistors and analog molecular flux in chemical reactions obey Boltzmann exponential laws of thermodynamics and are described by astoundingly similar logarithmic electrochemical potentials. Therefore, cytomorphic circuits can help to map circuit designs between electronic and biochemical domains. We review recent work that uses positive-feedback linearization circuits to architect wide-dynamic-range logarithmic analog computation in Escherichia coli using three transcription factors, nearly two orders of magnitude more efficient in parts than prior digital implementations. PMID:24567476

Analysis of rotor noise using LES

NASA Astrophysics Data System (ADS)

Keller, Jacob; Kumar, Praveen; Mahesh, Krishnan

2017-11-01

The flow field of a five-bladed marine propeller operating at design condition, obtained using large eddy simulation (LES), is used to calculate far-field sound. Three acoustic formulations are used: a point force dipole model, Curle acoustic analogy, and Ffowcs-Williams and Hawkings acoustic analogy. Each formulation is derived from the Navier-Stokes equations and the effects of the underlying assumptions are examined. The acoustic surface for the Curle and Ffowcs-Williams and Hawkings acoustic analogies is chosen to be the propeller; the propeller is split into a collection of acoustically compact radial strips. The computed sound is analyzed and the physics of sound generation is inspected. Results including far-field sound spectra and directivity will be discussed. This work is supported by the Office of Naval Research.

Computational Analyses in Support of Sub-scale Diffuser Testing for the A-3 Facility. Part 3; Aero-Acoustic Analyses and Experimental Validation

NASA Technical Reports Server (NTRS)

Allgood, Daniel C.; Graham, Jason S.; McVay, Greg P.; Langford, Lester L.

2008-01-01

A unique assessment of acoustic similarity scaling laws and acoustic analogy methodologies in predicting the far-field acoustic signature from a sub-scale altitude rocket test facility at the NASA Stennis Space Center was performed. A directional, point-source similarity analysis was implemented for predicting the acoustic far-field. In this approach, experimental acoustic data obtained from "similar" rocket engine tests were appropriately scaled using key geometric and dynamic parameters. The accuracy of this engineering-level method is discussed by comparing the predictions with acoustic far-field measurements obtained. In addition, a CFD solver was coupled with a Lilley's acoustic analogy formulation to determine the improvement of using a physics-based methodology over an experimental correlation approach. In the current work, steady-state Reynolds-averaged Navier-Stokes calculations were used to model the internal flow of the rocket engine and altitude diffuser. These internal flow simulations provided the necessary realistic input conditions for external plume simulations. The CFD plume simulations were then used to provide the spatial turbulent noise source distributions in the acoustic analogy calculations. Preliminary findings of these studies will be discussed.

Scalable hybrid computation with spikes.

PubMed

Sarpeshkar, Rahul; O'Halloran, Micah

2002-09-01

We outline a hybrid analog-digital scheme for computing with three important features that enable it to scale to systems of large complexity: First, like digital computation, which uses several one-bit precise logical units to collectively compute a precise answer to a computation, the hybrid scheme uses several moderate-precision analog units to collectively compute a precise answer to a computation. Second, frequent discrete signal restoration of the analog information prevents analog noise and offset from degrading the computation. And, third, a state machine enables complex computations to be created using a sequence of elementary computations. A natural choice for implementing this hybrid scheme is one based on spikes because spike-count codes are digital, while spike-time codes are analog. We illustrate how spikes afford easy ways to implement all three components of scalable hybrid computation. First, as an important example of distributed analog computation, we show how spikes can create a distributed modular representation of an analog number by implementing digital carry interactions between spiking analog neurons. Second, we show how signal restoration may be performed by recursive spike-count quantization of spike-time codes. And, third, we use spikes from an analog dynamical system to trigger state transitions in a digital dynamical system, which reconfigures the analog dynamical system using a binary control vector; such feedback interactions between analog and digital dynamical systems create a hybrid state machine (HSM). The HSM extends and expands the concept of a digital finite-state-machine to the hybrid domain. We present experimental data from a two-neuron HSM on a chip that implements error-correcting analog-to-digital conversion with the concurrent use of spike-time and spike-count codes. We also present experimental data from silicon circuits that implement HSM-based pattern recognition using spike-time synchrony. We outline how HSMs may be used to perform learning, vector quantization, spike pattern recognition and generation, and how they may be reconfigured.

A Digitally Programmable Cytomorphic Chip for Simulation of Arbitrary Biochemical Reaction Networks.

PubMed

Woo, Sung Sik; Kim, Jaewook; Sarpeshkar, Rahul

2018-04-01

Prior work has shown that compact analog circuits can faithfully represent and model fundamental biomolecular circuits via efficient log-domain cytomorphic transistor equivalents. Such circuits have emphasized basis functions that are dominant in genetic transcription and translation networks and deoxyribonucleic acid (DNA)-protein binding. Here, we report a system featuring digitally programmable 0.35 μm BiCMOS analog cytomorphic chips that enable arbitrary biochemical reaction networks to be exactly represented thus enabling compact and easy composition of protein networks as well. Since all biomolecular networks can be represented as chemical reaction networks, our protein networks also include the former genetic network circuits as a special case. The cytomorphic analog protein circuits use one fundamental association-dissociation-degradation building-block circuit that can be configured digitally to exactly represent any zeroth-, first-, and second-order reaction including loading, dynamics, nonlinearity, and interactions with other building-block circuits. To address a divergence issue caused by random variations in chip fabrication processes, we propose a unique way of performing computation based on total variables and conservation laws, which we instantiate at both the circuit and network levels. Thus, scalable systems that operate with finite error over infinite time can be built. We show how the building-block circuits can be composed to form various network topologies, such as cascade, fan-out, fan-in, loop, dimerization, or arbitrary networks using total variables. We demonstrate results from a system that combines interacting cytomorphic chips to simulate a cancer pathway and a glycolysis pathway. Both simulations are consistent with conventional software simulations. Our highly parallel digitally programmable analog cytomorphic systems can lead to a useful design, analysis, and simulation tool for studying arbitrary large-scale biological networks in systems and synthetic biology.

In silico design and screening of hypothetical MOF-74 analogs and their experimental synthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witman, Matthew; Ling, Sanliang; Anderson, Samantha

Here, we present the in silico design of metal-organic frameworks (MOFs) exhibiting 1-dimensional rod topologies. We then introduce an algorithm for construction of this family of MOF topologies, and illustrate its application for enumerating MOF-74-type analogs. Furthermore, we perform a broad search for new linkers that satisfy the topological requirements of MOF-74 and consider the largest database of known chemical space for organic compounds, the PubChem database. Our in silico crystal assembly, when combined with dispersion-corrected density functional theory (DFT) calculations, is demonstrated to generate a hypothetical library of open-metal site containing MOF-74 analogs in the 1-D rod topology frommore » which we can simulate the adsorption behavior of CO 2 . We conclude that these hypothetical structures have synthesizable potential through computational identification and experimental validation of a novel MOF-74 analog, Mg 2 (olsalazine).« less

In silico design and screening of hypothetical MOF-74 analogs and their experimental synthesis

DOE PAGES

Witman, Matthew; Ling, Sanliang; Anderson, Samantha; ...

2016-06-21

Here, we present the in silico design of metal-organic frameworks (MOFs) exhibiting 1-dimensional rod topologies. We then introduce an algorithm for construction of this family of MOF topologies, and illustrate its application for enumerating MOF-74-type analogs. Furthermore, we perform a broad search for new linkers that satisfy the topological requirements of MOF-74 and consider the largest database of known chemical space for organic compounds, the PubChem database. Our in silico crystal assembly, when combined with dispersion-corrected density functional theory (DFT) calculations, is demonstrated to generate a hypothetical library of open-metal site containing MOF-74 analogs in the 1-D rod topology frommore » which we can simulate the adsorption behavior of CO 2 . We conclude that these hypothetical structures have synthesizable potential through computational identification and experimental validation of a novel MOF-74 analog, Mg 2 (olsalazine).« less

Fast-response free-running dc-to-dc converter employing a state-trajectory control law

NASA Technical Reports Server (NTRS)

Huffman, S. D.; Burns, W. W., III; Wilson, T. G.; Owen, H. A., Jr.

1977-01-01

A recently proposed state-trajectory control law for a family of energy-storage dc-to-dc converters has been implemented for the voltage step-up configuration. Two methods of realization are discussed; one employs a digital processor and the other uses analog computational circuits. Performance characteristics of experimental voltage step-up converters operating under the control of each of these implementations are reported and compared to theoretical predictions and computer simulations.

Building Synthetic Sterols Computationally – Unlocking the Secrets of Evolution?

PubMed Central

Róg, Tomasz; Pöyry, Sanja; Vattulainen, Ilpo

2015-01-01

Cholesterol is vital in regulating the physical properties of animal cell membranes. While it remains unclear what renders cholesterol so unique, it is known that other sterols are less capable in modulating membrane properties, and there are membrane proteins whose function is dependent on cholesterol. Practical applications of cholesterol include its use in liposomes in drug delivery and cosmetics, cholesterol-based detergents in membrane protein crystallography, its fluorescent analogs in studies of cholesterol transport in cells and tissues, etc. Clearly, in spite of their difficult synthesis, producing the synthetic analogs of cholesterol is of great commercial and scientific interest. In this article, we discuss how synthetic sterols non-existent in nature can be used to elucidate the roles of cholesterol’s structural elements. To this end, we discuss recent atomistic molecular dynamics simulation studies that have predicted new synthetic sterols with properties comparable to those of cholesterol. We also discuss more recent experimental studies that have vindicated these predictions. The paper highlights the strength of computational simulations in making predictions for synthetic biology, thereby guiding experiments. PMID:26347865

Development and application of a non-Gaussian atmospheric turbulence model for use in flight simulators

NASA Technical Reports Server (NTRS)

Reeves, P. M.; Campbell, G. S.; Ganzer, V. M.; Joppa, R. G.

1974-01-01

A method is described for generating time histories which model the frequency content and certain non-Gaussian probability characteristics of atmospheric turbulence including the large gusts and patchy nature of turbulence. Methods for time histories using either analog or digital computation are described. A STOL airplane was programmed into a 6-degree-of-freedom flight simulator, and turbulence time histories from several atmospheric turbulence models were introduced. The pilots' reactions are described.

Energy efficient hybrid computing systems using spin devices

NASA Astrophysics Data System (ADS)

Sharad, Mrigank

Emerging spin-devices like magnetic tunnel junctions (MTJ's), spin-valves and domain wall magnets (DWM) have opened new avenues for spin-based logic design. This work explored potential computing applications which can exploit such devices for higher energy-efficiency and performance. The proposed applications involve hybrid design schemes, where charge-based devices supplement the spin-devices, to gain large benefits at the system level. As an example, lateral spin valves (LSV) involve switching of nanomagnets using spin-polarized current injection through a metallic channel such as Cu. Such spin-torque based devices possess several interesting properties that can be exploited for ultra-low power computation. Analog characteristic of spin current facilitate non-Boolean computation like majority evaluation that can be used to model a neuron. The magneto-metallic neurons can operate at ultra-low terminal voltage of ˜20mV, thereby resulting in small computation power. Moreover, since nano-magnets inherently act as memory elements, these devices can facilitate integration of logic and memory in interesting ways. The spin based neurons can be integrated with CMOS and other emerging devices leading to different classes of neuromorphic/non-Von-Neumann architectures. The spin-based designs involve `mixed-mode' processing and hence can provide very compact and ultra-low energy solutions for complex computation blocks, both digital as well as analog. Such low-power, hybrid designs can be suitable for various data processing applications like cognitive computing, associative memory, and currentmode on-chip global interconnects. Simulation results for these applications based on device-circuit co-simulation framework predict more than ˜100x improvement in computation energy as compared to state of the art CMOS design, for optimal spin-device parameters.

Grand canonical ensemble Monte Carlo simulation of the dCpG/proflavine crystal hydrate.

PubMed Central

Resat, H; Mezei, M

1996-01-01

The grand canonical ensemble Monte Carlo molecular simulation method is used to investigate hydration patterns in the crystal hydrate structure of the dCpG/proflavine intercalated complex. The objective of this study is to show by example that the recently advocated grand canonical ensemble simulation is a computationally efficient method for determining the positions of the hydrating water molecules in protein and nucleic acid structures. A detailed molecular simulation convergence analysis and an analogous comparison of the theoretical results with experiments clearly show that the grand ensemble simulations can be far more advantageous than the comparable canonical ensemble simulations. Images FIGURE 5 FIGURE 7 PMID:8873992

Computer simulation analysis of the behavior of renal-regulating hormones during hypogravic stress

NASA Technical Reports Server (NTRS)

Leonard, J. I.

1982-01-01

A computer simulation of a mathematical circulation model is used to study the alterations of body fluids and their electrolyte composition that occur in weightlessness. The behavior of the renal-regulating hormones which control these alterations is compared in simulations of several one-g analogs of weightlessness and space flight. It is shown that the renal-regulating hormones represent a tightly coupled system that responds acutely to volume disturbances and chronically to electrolyte disturbances. During hypogravic conditions these responses lead to an initial suppression of hormone levels and a long-term effect which varies depending on metabolic factors that can alter the plasma electrolytes. In addition, it is found that if pressure effects normalize rapidly, a transition phase may exist which leads to a dynamic multiphasic endocrine response.

Science beyond fiction. A revolution of knowledge transfer in research, education, and practice is on the horizon.

PubMed

Ammann, Alexander

2016-01-01

"Digitality" (as opposed to "digitalization"--the conversion from the analog domain to the digital domain) will open up a whole new world that does not originate from the analog world. Contemporary research in the field of neural concepts and neuromorphic computing systems will lead to convergences between the world of digitality and the world of neuronality, giving the theme "Knowledge and Culture" a new meaning. The simulation of virtual multidimensional and contextual spaces will transform the transfer of knowledge from a uni- and bidirectional process into an interactive experience. We will learn to learn in a ubiquitous computing environment and will abandon conventional curriculum organization principles. The adaptation of individualized ontologies will result in the emergence of a new world of knowledge in which knowledge evolves from a cultural heritage into a commodity.

From particle condensation to polymer aggregation

NASA Astrophysics Data System (ADS)

Janke, Wolfhard; Zierenberg, Johannes

2018-01-01

We draw an analogy between droplet formation in dilute particle and polymer systems. Our arguments are based on finite-size scaling results from studies of a two-dimensional lattice gas to three-dimensional bead-spring polymers. To set the results in perspective, we compare with in part rigorous theoretical scaling laws for canonical condensation in a supersaturated gas at fixed temperature, and derive corresponding scaling predictions for an undercooled gas at fixed density. The latter allows one to efficiently employ parallel multicanonical simulations and to reach previously not accessible scaling regimes. While the asymptotic scaling can not be observed for the comparably small polymer system sizes, they demonstrate an intermediate scaling regime also observable for particle condensation. Altogether, our extensive results from computer simulations provide clear evidence for the close analogy between particle condensation and polymer aggregation in dilute systems.

Adaptive time steps in trajectory surface hopping simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spörkel, Lasse, E-mail: spoerkel@kofo.mpg.de; Thiel, Walter, E-mail: thiel@kofo.mpg.de

2016-05-21

Trajectory surface hopping (TSH) simulations are often performed in combination with active-space multi-reference configuration interaction (MRCI) treatments. Technical problems may arise in such simulations if active and inactive orbitals strongly mix and switch in some particular regions. We propose to use adaptive time steps when such regions are encountered in TSH simulations. For this purpose, we present a computational protocol that is easy to implement and increases the computational effort only in the critical regions. We test this procedure through TSH simulations of a GFP chromophore model (OHBI) and a light-driven rotary molecular motor (F-NAIBP) on semiempirical MRCI potential energymore » surfaces, by comparing the results from simulations with adaptive time steps to analogous ones with constant time steps. For both test molecules, the number of successful trajectories without technical failures rises significantly, from 53% to 95% for OHBI and from 25% to 96% for F-NAIBP. The computed excited-state lifetime remains essentially the same for OHBI and increases somewhat for F-NAIBP, and there is almost no change in the computed quantum efficiency for internal rotation in F-NAIBP. We recommend the general use of adaptive time steps in TSH simulations with active-space CI methods because this will help to avoid technical problems, increase the overall efficiency and robustness of the simulations, and allow for a more complete sampling.« less

Adaptive time steps in trajectory surface hopping simulations

NASA Astrophysics Data System (ADS)

Spörkel, Lasse; Thiel, Walter

2016-05-01

Trajectory surface hopping (TSH) simulations are often performed in combination with active-space multi-reference configuration interaction (MRCI) treatments. Technical problems may arise in such simulations if active and inactive orbitals strongly mix and switch in some particular regions. We propose to use adaptive time steps when such regions are encountered in TSH simulations. For this purpose, we present a computational protocol that is easy to implement and increases the computational effort only in the critical regions. We test this procedure through TSH simulations of a GFP chromophore model (OHBI) and a light-driven rotary molecular motor (F-NAIBP) on semiempirical MRCI potential energy surfaces, by comparing the results from simulations with adaptive time steps to analogous ones with constant time steps. For both test molecules, the number of successful trajectories without technical failures rises significantly, from 53% to 95% for OHBI and from 25% to 96% for F-NAIBP. The computed excited-state lifetime remains essentially the same for OHBI and increases somewhat for F-NAIBP, and there is almost no change in the computed quantum efficiency for internal rotation in F-NAIBP. We recommend the general use of adaptive time steps in TSH simulations with active-space CI methods because this will help to avoid technical problems, increase the overall efficiency and robustness of the simulations, and allow for a more complete sampling.

ELECTRONIC ANALOG COMPUTER FOR DETERMINING RADIOACTIVE DISINTEGRATION

DOEpatents

Robinson, H.P.

1959-07-14

A computer is presented for determining growth and decay curves for elements in a radioactive disintegration series wherein one unstable element decays to form a second unstable element or isotope, which in turn forms a third element, etc. The growth and decay curves of radioactive elements are simulated by the charge and discharge curves of a resistance-capacitance network. Several such networks having readily adjustable values are connected in series with an amplifier between each successive pair. The time constant of each of the various networks is set proportional to the half-life of a corresponding element in the series represented and the charge and discharge curves of each of the networks simulates the element growth and decay curve.

Interactive NMR: A Simulation Based Teaching Tool for Fundamentals to Applications with Tangible Analogies

NASA Astrophysics Data System (ADS)

Griesse-Nascimento, Sarah; Bridger, Joshua; Brown, Keith; Westervelt, Robert

2011-03-01

Interactive computer simulations increase students' understanding of difficult concepts and their ability to explain complex ideas. We created a module of eight interactive programs and accompanying lesson plans for teaching the fundamental concepts of Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) that we call interactive NMR (iNMR). We begin with an analogy between nuclear spins and metronomes to start to build intuition about the dynamics of spins in a magnetic field. We continue to explain T1, T2, and pulse sequences with the metronome analogy. The final three programs are used to introduce and explain the Magnetic Resonance Switch, a recent diagnostic technique based on NMR. A modern relevant application is useful to generate interest in the topic and confidence in the students' ability to apply their knowledge. The iNMR module was incorporated into a high school AP physics class. In a preliminary evaluation of implementation, students expressed enthusiasm and demonstrated enhanced understanding of the material relative to the previous year. Funded by NSF PHY-0646094 grant.

Neural dynamics in reconfigurable silicon.

PubMed

Basu, A; Ramakrishnan, S; Petre, C; Koziol, S; Brink, S; Hasler, P E

2010-10-01

A neuromorphic analog chip is presented that is capable of implementing massively parallel neural computations while retaining the programmability of digital systems. We show measurements from neurons with Hopf bifurcations and integrate and fire neurons, excitatory and inhibitory synapses, passive dendrite cables, coupled spiking neurons, and central pattern generators implemented on the chip. This chip provides a platform for not only simulating detailed neuron dynamics but also uses the same to interface with actual cells in applications such as a dynamic clamp. There are 28 computational analog blocks (CAB), each consisting of ion channels with tunable parameters, synapses, winner-take-all elements, current sources, transconductance amplifiers, and capacitors. There are four other CABs which have programmable bias generators. The programmability is achieved using floating gate transistors with on-chip programming control. The switch matrix for interconnecting the components in CABs also consists of floating-gate transistors. Emphasis is placed on replicating the detailed dynamics of computational neural models. Massive computational area efficiency is obtained by using the reconfigurable interconnect as synaptic weights, resulting in more than 50 000 possible 9-b accurate synapses in 9 mm(2).

Reconfigurable Analog PDE computation for Baseband and RFComputation

DTIC Science & Technology

2017-03-01

waveguiding PDEs. One-dimensional ladder topologies enable linear delays, linear-phase analog filters , as well as analog beamforming, potentially at RF...performance. This discussion focuses on ODE / PDE analog computation available in SoC FPAA structures. One such computation is a ladder filter (Fig...Implementation of a one-dimensional ladder filter for computing inductor (L) and capacitor (C) lines. These components can be implemented in CABs or as

On zero variance Monte Carlo path-stretching schemes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lux, I.

1983-08-01

A zero variance path-stretching biasing scheme proposed for a special case by Dwivedi is derived in full generality. The procedure turns out to be the generalization of the exponential transform. It is shown that the biased game can be interpreted as an analog simulation procedure, thus saving some computational effort in comparison with the corresponding nonanalog game.

Brake control system modification, augmentor Wing Jet STOL Research Airplane (AWJSRA)

NASA Technical Reports Server (NTRS)

Amberg, R. L.; Arline, J. A.; Jenny, R. W.

1974-01-01

The braking system for a short takeoff aircraft is discussed and the deficiencies are described. The installation of a Boeing 727 aircraft brake system was made to correct the deficiencies. Tests of the modified system were conducted using an analog computer/hardware simulator. Actual performance tests were conducted and the characteristics of the system were satisfactory.

Classical problems in computational aero-acoustics

NASA Technical Reports Server (NTRS)

Hardin, Jay C.

1996-01-01

In relation to the expected problems in the development of computational aeroacoustics (CAA), the preliminary applications were to classical problems where the known analytical solutions could be used to validate the numerical results. Such comparisons were used to overcome the numerical problems inherent in these calculations. Comparisons were made between the various numerical approaches to the problems such as direct simulations, acoustic analogies and acoustic/viscous splitting techniques. The aim was to demonstrate the applicability of CAA as a tool in the same class as computational fluid dynamics. The scattering problems that occur are considered and simple sources are discussed.

Enhancing programming logic thinking using analogy mapping

NASA Astrophysics Data System (ADS)

Sukamto, R. A.; Megasari, R.

2018-05-01

Programming logic thinking is the most important competence for computer science students. However, programming is one of the difficult subject in computer science program. This paper reports our work about enhancing students' programming logic thinking using Analogy Mapping for basic programming subject. Analogy Mapping is a computer application which converts source code into analogies images. This research used time series evaluation and the result showed that Analogy Mapping can enhance students' programming logic thinking.

Programming of a flexible computer simulation to visualize pharmacokinetic-pharmacodynamic models.

PubMed

Lötsch, J; Kobal, G; Geisslinger, G

2004-01-01

Teaching pharmacokinetic-pharmacodynamic (PK/PD) models can be made more effective using computer simulations. We propose the programming of educational PK or PK/PD computer simulations as an alternative to the use of pre-built simulation software. This approach has the advantage of adaptability to non-standard or complicated PK or PK/PD models. Simplicity of the programming procedure was achieved by selecting the LabVIEW programming environment. An intuitive user interface to visualize the time courses of drug concentrations or effects can be obtained with pre-built elements. The environment uses a wiring analogy that resembles electrical circuit diagrams rather than abstract programming code. The goal of high interactivity of the simulation was attained by allowing the program to run in continuously repeating loops. This makes the program behave flexibly to the user input. The programming is described with the aid of a 2-compartment PK simulation. Examples of more sophisticated simulation programs are also given where the PK/PD simulation shows drug input, concentrations in plasma, and at effect site and the effects themselves as a function of time. A multi-compartmental model of morphine, including metabolite kinetics and effects is also included. The programs are available for download from the World Wide Web at http:// www. klinik.uni-frankfurt.de/zpharm/klin/ PKPDsimulation/content.html. For pharmacokineticists who only program occasionally, there is the possibility of building the computer simulation, together with the flexible interactive simulation algorithm for clinical pharmacological teaching in the field of PK/PD models.

An Invitation to Kitchen Earth Sciences, an Example of MISO Soup Convection Experiment in Classroom

NASA Astrophysics Data System (ADS)

Kurita, K.; Kumagai, I.; Davaille, A.

2008-12-01

In recent frontiers of earth sciences such as computer simulations and large-scale observations/experiments involved researchers are usually remote from the targets and feel difficulty in having a sense of touching the phenomena in hands. This results in losing sympathy for natural phenomena particularly among young researchers, which we consider a serious problem. We believe the analog experiments such as the subjects of "kitchen earth sciences" proposed here can be a remedy for this. Analog experiments have been used as an important tool in various research fields of earth science, particularly in the fields of developing new ideas. The experiment by H. Ramberg by using silicone pate is famous for guiding concept of the mantle dynamics. The term, "analog" means something not directly related to the target of the research but in analogical sense parallel comparison is possible. The advantages of the analog experiments however seem to have been overwhelmed by rapid progresses of computer simulations. Although we still believe in the present-day meaning, recently we are recognizing another aspect of its significance. The essence of "kitchen earth science" as an analog experiment is to provide experimental setups and materials easily from the kitchen, by which everyone can start experiments and participate in the discussion without special preparations because of our daily-experienced matter. Here we will show one such example which can be used as a heuristic subject in the classrooms at introductory level of earth science as well as in lunch time break of advanced researchers. In heated miso soup the fluid motion can be easily traced by the motion of miso "particles". At highly heated state immiscible part of miso convects with aqueous fluid. At intermediate heating the miso part precipitates to form a sediment layer at the bottom. This layered structure is destroyed regularly by the instability caused by accumulated heat in the miso layer as a bursting. By showing interesting movie we will discuss characteristics of the bursting and possible implications in the understanding of layered system in the planetary interior in the style of lunch time discussion.

Synthetic Biology: A Unifying View and Review Using Analog Circuits.

PubMed

Teo, Jonathan J Y; Woo, Sung Sik; Sarpeshkar, Rahul

2015-08-01

We review the field of synthetic biology from an analog circuits and analog computation perspective, focusing on circuits that have been built in living cells. This perspective is well suited to pictorially, symbolically, and quantitatively representing the nonlinear, dynamic, and stochastic (noisy) ordinary and partial differential equations that rigorously describe the molecular circuits of synthetic biology. This perspective enables us to construct a canonical analog circuit schematic that helps unify and review the operation of many fundamental circuits that have been built in synthetic biology at the DNA, RNA, protein, and small-molecule levels over nearly two decades. We review 17 circuits in the literature as particular examples of feedforward and feedback analog circuits that arise from special topological cases of the canonical analog circuit schematic. Digital circuit operation of these circuits represents a special case of saturated analog circuit behavior and is automatically incorporated as well. Many issues that have prevented synthetic biology from scaling are naturally represented in analog circuit schematics. Furthermore, the deep similarity between the Boltzmann thermodynamic equations that describe noisy electronic current flow in subthreshold transistors and noisy molecular flux in biochemical reactions has helped map analog circuit motifs in electronics to analog circuit motifs in cells and vice versa via a `cytomorphic' approach. Thus, a body of knowledge in analog electronic circuit design, analysis, simulation, and implementation may also be useful in the robust and efficient design of molecular circuits in synthetic biology, helping it to scale to more complex circuits in the future.

Designing, building, and testing a solar thermoelectric generation, STEG, for energy delivery to remote residential areas in developing regions

NASA Astrophysics Data System (ADS)

Moumouni, Yacouba

New alternatives and inventive renewable energy techniques which encompass both generation and power management solutions are fundamental for meeting remote residential energy supply and demand today, especially if the grid is quasi-inexistent. Solar thermoelectric generators can be a cost-effective alternative to photovoltaics for a remote residential household power supply. A complete solar thermoelectric energy harvesting system is presented for energy delivery to remote residential areas in developing regions. To this end, the entire system was built, modeled, and then validated with LTspice simulator software via thermal-to-electrical analogy schemes. Valuable data in conjunction with two novel LTspice circuits were obtained, showing the achievability of analyzing transient heat transfer with the Spice simulator. Hence, the proposed study begins with a comprehensive method of extracting thermal parameters that appear in thermoelectric modules. A step-by-step procedure was developed and followed to succinctly extract parameters, such as the Seebeck coefficient, electrical conductivity, thermal resistance, and thermal conductivity needed to model the system. Data extracted from datasheet, material properties, and geometries were successfully utilized to compute the thermal capacities and resistances necessary to perform the analogy. In addition, temperature variations of the intrinsic internal parameters were accounted for in this process for accuracy purposes. The steps that it takes to simulate any thermo-electrical system with the LTspice simulator are thoroughly explained in this work. As a consequence, an improved Spice model for a thermoelectric generator is proposed. Experimental results were compiled in the form of a lookup table and then fed into the Spice simulator using the piecewise linear (PWL) command in order to validate the model. Experimental results show that a temperature differential of 13.43°C was achievable whereas the simulation indicates a temperature gap of 9.86°C, with the higher error being associated with the hot side. Also, since the analytical method of transient heat transfer analysis is cumbersome, an LTspice model of a real-world solar thermoelectric generation system was investigated. All the physical parameters were converted into their electrical equivalences through the thermal-to-electrical analogy. Real site direct normal insolation was fed into the Spice model via PWL in order to capture the true system's thermal behavior. Interestingly, two distinct analogies result from this study: 1) an RC analogy and 2) another analogy similar to an N-type doped semiconductor material's carrier density dependence with temperature. The RC analogy is derived in order to demonstrate how thermoelectric generation systems respond to square wave-like solar radiation. This analogy is utilized to measure temperature variations on the cold side of the Spice model; it shows 80% accuracy. The N-type analogy is intended to help analyze the actual performance of a LTC3105 converter. However a few of the problems to be solved remain at the practical level. Despite the unusual operation of the thermoelectric modules with the solar radiation, the measurements and simulation were in good agreement, thus validating the new thermal modeling strategy.

Atmospheric simulation using a liquid crystal wavefront-controlling device

NASA Astrophysics Data System (ADS)

Brooks, Matthew R.; Goda, Matthew E.

2004-10-01

Test and evaluation of laser warning devices is important due to the increased use of laser devices in aerial applications. This research consists of an atmospheric aberrating system to enable in-lab testing of various detectors and sensors. This system employs laser light at 632.8nm from a Helium-Neon source and a spatial light modulator (SLM) to cause phase changes using a birefringent liquid crystal material. Measuring outgoing radiation from the SLM using a CCD targetboard and Shack-Hartmann wavefront sensor reveals an acceptable resemblance of system output to expected atmospheric theory. Over three turbulence scenarios, an error analysis reveals that turbulence data matches theory. A wave optics computer simulation is created analogous to the lab-bench design. Phase data, intensity data, and a computer simulation affirm lab-bench results so that the aberrating SLM system can be operated confidently.

Network Simulation solution of free convective flow from a vertical cone with combined effect of non- uniform surface heat flux and heat generation or absorption

NASA Astrophysics Data System (ADS)

Immanuel, Y.; Pullepu, Bapuji; Sambath, P.

2018-04-01

A two dimensional mathematical model is formulated for the transitive laminar free convective, incompressible viscous fluid flow over vertical cone with variable surface heat flux combined with the effects of heat generation and absorption is considered . using a powerful computational method based on thermoelectric analogy called Network Simulation Method (NSM0, the solutions of governing nondimensionl coupled, unsteady and nonlinear partial differential conservation equations of the flow that are obtained. The numerical technique is always stable and convergent which establish high efficiency and accuracy by employing network simulator computer code Pspice. The effects of velocity and temperature profiles have been analyzed for various factors, namely Prandtl number Pr, heat flux power law exponent n and heat generation/absorption parameter Δ are analyzed graphically.

A system for automatic evaluation of simulation software

NASA Technical Reports Server (NTRS)

Ryan, J. P.; Hodges, B. C.

1976-01-01

Within the field of computer software, simulation and verification are complementary processes. Simulation methods can be used to verify software by performing variable range analysis. More general verification procedures, such as those described in this paper, can be implicitly, viewed as attempts at modeling the end-product software. From software requirement methodology, each component of the verification system has some element of simulation to it. Conversely, general verification procedures can be used to analyze simulation software. A dynamic analyzer is described which can be used to obtain properly scaled variables for an analog simulation, which is first digitally simulated. In a similar way, it is thought that the other system components and indeed the whole system itself have the potential of being effectively used in a simulation environment.

Numerical characterization of landing gear aeroacoustics using advanced simulation and analysis techniques

NASA Astrophysics Data System (ADS)

Redonnet, S.; Ben Khelil, S.; Bulté, J.; Cunha, G.

2017-09-01

With the objective of aircraft noise mitigation, we here address the numerical characterization of the aeroacoustics by a simplified nose landing gear (NLG), through the use of advanced simulation and signal processing techniques. To this end, the NLG noise physics is first simulated through an advanced hybrid approach, which relies on Computational Fluid Dynamics (CFD) and Computational AeroAcoustics (CAA) calculations. Compared to more traditional hybrid methods (e.g. those relying on the use of an Acoustic Analogy), and although it is used here with some approximations made (e.g. design of the CFD-CAA interface), the present approach does not rely on restrictive assumptions (e.g. equivalent noise source, homogeneous propagation medium), which allows to incorporate more realism into the prediction. In a second step, the outputs coming from such CFD-CAA hybrid calculations are processed through both traditional and advanced post-processing techniques, thus offering to further investigate the NLG's noise source mechanisms. Among other things, this work highlights how advanced computational methodologies are now mature enough to not only simulate realistic problems of airframe noise emission, but also to investigate their underlying physics.

ANOPP/VMS HSCT ground contour system

NASA Technical Reports Server (NTRS)

Rawls, John, Jr.; Glaab, Lou

1992-01-01

This viewgraph shows the integration of the Visual Motion Simulator with ANOPP. ANOPP is an acronym for the Aircraft NOise Prediction Program. It is a computer code consisting of dedicated noise prediction modules for jet, propeller, and rotor powered aircraft along with flight support and noise propagation modules, all executed under the control of an executive system. The Visual Motion Simulator (VMS) is a ground based motion simulator with six degrees of freedom. The transport-type cockpit is equipped with conventional flight and engine-thrust controls and with flight instrument displays. Control forces on the wheel, column, and rudder pedals are provided by a hydraulic system coupled with an analog computer. The simulator provides variable-feel characteristics of stiffness, damping, coulomb friction, breakout forces, and inertia. The VMS provides a wide range of realistic flight trajectories necessary for computing accurate ground contours. The NASA VMS will be discussed in detail later in this presentation. An equally important part of the system for both ANOPP and VMS is the engine performance. This will also be discussed in the presentation.

Response of an all digital phase-locked loop

NASA Technical Reports Server (NTRS)

Garodnick, J.; Greco, J.; Schilling, D. L.

1974-01-01

An all digital phase-locked loop (DPLL) is designed, analyzed, and tested. Three specific configurations are considered, generating first, second, and third order DPLL's; and it is found, using a computer simulation of a noise spike, and verified experimentally, that of these configurations the second-order system is optimum from the standpoint of threshold extension. This substantiates results obtained for analog PLL's.

Joint Services Electronics Program

DTIC Science & Technology

1992-03-05

Packaging Considerations M. T. Raghunath (Professor Abhiram Ranade) A central issue in massively parallel computation is the design of the interconnection...programs on promising network architectures. Publications: [1] M. T. Raghunath and A. G. Ranade, A Simulation-Based Compari- son of Interconnection Networks...more difficult analog function approximation task. Network Design Issues for Fast Global Communication Professor A. Ranade with M.T. Raghunath A

SiMon: Simulation Monitor for Computational Astrophysics

NASA Astrophysics Data System (ADS)

Xuran Qian, Penny; Cai, Maxwell Xu; Portegies Zwart, Simon; Zhu, Ming

2017-09-01

Scientific discovery via numerical simulations is important in modern astrophysics. This relatively new branch of astrophysics has become possible due to the development of reliable numerical algorithms and the high performance of modern computing technologies. These enable the analysis of large collections of observational data and the acquisition of new data via simulations at unprecedented accuracy and resolution. Ideally, simulations run until they reach some pre-determined termination condition, but often other factors cause extensive numerical approaches to break down at an earlier stage. In those cases, processes tend to be interrupted due to unexpected events in the software or the hardware. In those cases, the scientist handles the interrupt manually, which is time-consuming and prone to errors. We present the Simulation Monitor (SiMon) to automatize the farming of large and extensive simulation processes. Our method is light-weight, it fully automates the entire workflow management, operates concurrently across multiple platforms and can be installed in user space. Inspired by the process of crop farming, we perceive each simulation as a crop in the field and running simulation becomes analogous to growing crops. With the development of SiMon we relax the technical aspects of simulation management. The initial package was developed for extensive parameter searchers in numerical simulations, but it turns out to work equally well for automating the computational processing and reduction of observational data reduction.

Quantum Computing: Solving Complex Problems

ScienceCinema

DiVincenzo, David

2018-05-22

One of the motivating ideas of quantum computation was that there could be a new kind of machine that would solve hard problems in quantum mechanics. There has been significant progress towards the experimental realization of these machines (which I will review), but there are still many questions about how such a machine could solve computational problems of interest in quantum physics. New categorizations of the complexity of computational problems have now been invented to describe quantum simulation. The bad news is that some of these problems are believed to be intractable even on a quantum computer, falling into a quantum analog of the NP class. The good news is that there are many other new classifications of tractability that may apply to several situations of physical interest.

Reward-based learning under hardware constraints-using a RISC processor embedded in a neuromorphic substrate.

PubMed

Friedmann, Simon; Frémaux, Nicolas; Schemmel, Johannes; Gerstner, Wulfram; Meier, Karlheinz

2013-01-01

In this study, we propose and analyze in simulations a new, highly flexible method of implementing synaptic plasticity in a wafer-scale, accelerated neuromorphic hardware system. The study focuses on globally modulated STDP, as a special use-case of this method. Flexibility is achieved by embedding a general-purpose processor dedicated to plasticity into the wafer. To evaluate the suitability of the proposed system, we use a reward modulated STDP rule in a spike train learning task. A single layer of neurons is trained to fire at specific points in time with only the reward as feedback. This model is simulated to measure its performance, i.e., the increase in received reward after learning. Using this performance as baseline, we then simulate the model with various constraints imposed by the proposed implementation and compare the performance. The simulated constraints include discretized synaptic weights, a restricted interface between analog synapses and embedded processor, and mismatch of analog circuits. We find that probabilistic updates can increase the performance of low-resolution weights, a simple interface between analog synapses and processor is sufficient for learning, and performance is insensitive to mismatch. Further, we consider communication latency between wafer and the conventional control computer system that is simulating the environment. This latency increases the delay, with which the reward is sent to the embedded processor. Because of the time continuous operation of the analog synapses, delay can cause a deviation of the updates as compared to the not delayed situation. We find that for highly accelerated systems latency has to be kept to a minimum. This study demonstrates the suitability of the proposed implementation to emulate the selected reward modulated STDP learning rule. It is therefore an ideal candidate for implementation in an upgraded version of the wafer-scale system developed within the BrainScaleS project.

Reward-based learning under hardware constraints—using a RISC processor embedded in a neuromorphic substrate

PubMed Central

Friedmann, Simon; Frémaux, Nicolas; Schemmel, Johannes; Gerstner, Wulfram; Meier, Karlheinz

2013-01-01

In this study, we propose and analyze in simulations a new, highly flexible method of implementing synaptic plasticity in a wafer-scale, accelerated neuromorphic hardware system. The study focuses on globally modulated STDP, as a special use-case of this method. Flexibility is achieved by embedding a general-purpose processor dedicated to plasticity into the wafer. To evaluate the suitability of the proposed system, we use a reward modulated STDP rule in a spike train learning task. A single layer of neurons is trained to fire at specific points in time with only the reward as feedback. This model is simulated to measure its performance, i.e., the increase in received reward after learning. Using this performance as baseline, we then simulate the model with various constraints imposed by the proposed implementation and compare the performance. The simulated constraints include discretized synaptic weights, a restricted interface between analog synapses and embedded processor, and mismatch of analog circuits. We find that probabilistic updates can increase the performance of low-resolution weights, a simple interface between analog synapses and processor is sufficient for learning, and performance is insensitive to mismatch. Further, we consider communication latency between wafer and the conventional control computer system that is simulating the environment. This latency increases the delay, with which the reward is sent to the embedded processor. Because of the time continuous operation of the analog synapses, delay can cause a deviation of the updates as compared to the not delayed situation. We find that for highly accelerated systems latency has to be kept to a minimum. This study demonstrates the suitability of the proposed implementation to emulate the selected reward modulated STDP learning rule. It is therefore an ideal candidate for implementation in an upgraded version of the wafer-scale system developed within the BrainScaleS project. PMID:24065877

Radiation shielding evaluation of the BNCT treatment room at THOR: a TORT-coupled MCNP Monte Carlo simulation study.

PubMed

Chen, A Y; Liu, Y-W H; Sheu, R J

2008-01-01

This study investigates the radiation shielding design of the treatment room for boron neutron capture therapy at Tsing Hua Open-pool Reactor using "TORT-coupled MCNP" method. With this method, the computational efficiency is improved significantly by two to three orders of magnitude compared to the analog Monte Carlo MCNP calculation. This makes the calculation feasible using a single CPU in less than 1 day. Further optimization of the photon weight windows leads to additional 50-75% improvement in the overall computational efficiency.

Closed Loop Real-Time Evaluation of Missile Guidance and Control Components: Simulator Hardware/Software Characteristics and Use

DTIC Science & Technology

1974-08-01

Node Control Logic 2-27 2.16 Pitch Channel Frequence Response 2-36 2.17 Yaw Channel Frequency Response 2-37 K 4 2.18 Analog Computer Mechanlzation of...8217S 0 121 £l1:c IL-I. TABLE I Elements of the Slgma 5 Digital Computer System Xerox Model- Performance MIOP Channel Description Number Characteristics...transfer control signals to or from the CPU. The MIOP can handle up to 32 I/0 channels each operating simultaneously, provided the overall data

On the impact of approximate computation in an analog DeSTIN architecture.

PubMed

Young, Steven; Lu, Junjie; Holleman, Jeremy; Arel, Itamar

2014-05-01

Deep machine learning (DML) holds the potential to revolutionize machine learning by automating rich feature extraction, which has become the primary bottleneck of human engineering in pattern recognition systems. However, the heavy computational burden renders DML systems implemented on conventional digital processors impractical for large-scale problems. The highly parallel computations required to implement large-scale deep learning systems are well suited to custom hardware. Analog computation has demonstrated power efficiency advantages of multiple orders of magnitude relative to digital systems while performing nonideal computations. In this paper, we investigate typical error sources introduced by analog computational elements and their impact on system-level performance in DeSTIN--a compositional deep learning architecture. These inaccuracies are evaluated on a pattern classification benchmark, clearly demonstrating the robustness of the underlying algorithm to the errors introduced by analog computational elements. A clear understanding of the impacts of nonideal computations is necessary to fully exploit the efficiency of analog circuits.

3D Global Fluid Simulations of Turbulence in LAPD

NASA Astrophysics Data System (ADS)

Rogers, Barrett; Ricci, Paolo; Li, Bo

2009-05-01

We present 3D global fluid simulations of the UCLA upgraded Large Plasma Device (LAPD). This device confines an 18-m-long, cylindrically symmetric plasma with a uniform magnetic field. The plasma in the simulations is generated by density and temperature sources inside the computational domain, and sheath boundary conditions are applied at the ends of the plasma column. In 3D simulations of the entire plasma, we observe strong, rotating intermittent density and temperature fluctuations driven by resistive driftwave turbulence with finite parallel wavenumbers. Analogous simulations carried out in the 2D limit (that is, assuming that the motions are purely interchange-like) display much weaker mode activity driven a Kelvin-Helmholtz instability. The properties and scaling of the turbulence and transport will be discussed.

ARC-1971-AC71-6490

NASA Image and Video Library

1971-08-14

N-243 Flight and Guidance Centrifuge: Is used for spacecraft mission simulations and is adaptable to two configurations. Configuration 1: The cab will accommodate a three-man crew for space mission research. The accelerations and rates are intended to be smoothly applicable at very low value so the navigation and guidance procedures using a high-accuracy, out-the window display may be simulated. Configuration 2: The simulator can use a one-man cab for human tolerance studies and performance testing. Atmosphere and tempertaure can be varied as stress inducements. This simlator is operated closed-loop with digital or analog computation. It is currently man-rated for 3.5g maximum.

ARC-1971-AC71-6488

NASA Image and Video Library

1971-08-14

N-243 Flight and Guidance Centrifuge: Is used for spacecraft mission simulations and is adaptable to two configurations. Configuration 1: The cab will accommodate a three-man crew for space mission research. The accelerations and rates are intended to be smoothly applicable at very low value so the navigation and guidance procedures using a high-accuracy, out-the window display may be simulated. Configuration 2: The simulator can use a one-man cab for human tolerance studies and performance testing. Atmosphere and tempertaure can be varied as stress inducements. This simlator is operated closed-loop with digital or analog computation. It is currently man-rated for 3.5g maximum.

ARC-1971-AC71-6486

NASA Image and Video Library

1971-08-14

N-243 Flight and Guidance Centrifuge: Is used for spacecraft mission simulations and is adaptable to two configurations. Configuration 1: The cab will accommodate a three-man crew for space mission research. The accelerations and rates are intended to be smoothly applicable at very low value so the navigation and guidance procedures using a high-accuracy, out-the window display may be simulated. Configuration 2: The simulator can use a one-man cab for human tolerance studies and performance testing. Atmosphere and tempertaure can be varied as stress inducements. This simlator is operated closed-loop with digital or analog computation. It is currently man-rated for 3.5g maximum.

Design of a real-time wind turbine simulator using a custom parallel architecture

NASA Technical Reports Server (NTRS)

Hoffman, John A.; Gluck, R.; Sridhar, S.

1995-01-01

The design of a new parallel-processing digital simulator is described. The new simulator has been developed specifically for analysis of wind energy systems in real time. The new processor has been named: the Wind Energy System Time-domain simulator, version 3 (WEST-3). Like previous WEST versions, WEST-3 performs many computations in parallel. The modules in WEST-3 are pure digital processors, however. These digital processors can be programmed individually and operated in concert to achieve real-time simulation of wind turbine systems. Because of this programmability, WEST-3 is very much more flexible and general than its two predecessors. The design features of WEST-3 are described to show how the system produces high-speed solutions of nonlinear time-domain equations. WEST-3 has two very fast Computational Units (CU's) that use minicomputer technology plus special architectural features that make them many times faster than a microcomputer. These CU's are needed to perform the complex computations associated with the wind turbine rotor system in real time. The parallel architecture of the CU causes several tasks to be done in each cycle, including an IO operation and the combination of a multiply, add, and store. The WEST-3 simulator can be expanded at any time for additional computational power. This is possible because the CU's interfaced to each other and to other portions of the simulation using special serial buses. These buses can be 'patched' together in essentially any configuration (in a manner very similar to the programming methods used in analog computation) to balance the input/ output requirements. CU's can be added in any number to share a given computational load. This flexible bus feature is very different from many other parallel processors which usually have a throughput limit because of rigid bus architecture.

A fractional calculus perspective of distributed propeller design

NASA Astrophysics Data System (ADS)

Tenreiro Machado, J.; Galhano, Alexandra M.

2018-02-01

A new generation of aircraft with distributed propellers leads to operational performances superior to those exhibited by standard designs. Computational simulations and experimental tests show a reduction of fuel consumption and noise. This paper proposes an analogy between aerodynamics and electrical circuits. The model reveals properties similar to those of fractional-order systems and gives a deeper insight into the dynamics of multi-propeller coupling.

Synthesis of generalized surface plasmon beams

NASA Astrophysics Data System (ADS)

Martinez-Niconoff, G.; Munoz-Lopez, J.; Martinez-Vara, P.

2009-08-01

Surface plasmon modes can be considered as the analogous to plane waves for homogeneous media. The extension to partially coherent surface plasmon beams is obtained by means of the incoherent superposition of the interference between surface plasmon modes whose profile is controlled associating a probability density function to the structural parameters implicit in their representation. We show computational simulations for cosine, Bessel, gaussian and dark hollow surface plasmon beams.

a Real-Time Computer Music Synthesis System

NASA Astrophysics Data System (ADS)

Lent, Keith Henry

A real time sound synthesis system has been developed at the Computer Music Center of The University of Texas at Austin. This system consists of several stand alone processors that were constructed jointly with White Instruments in Austin. These processors can be programmed as general purpose computers, but are provided with a number of specialized interfaces including: MIDI, 8 bit parallel, high speed serial, 2 channels analog input (18 bit A/Ds, 48kHz sample rate), and 4 channels analog output (18 bit D/As). In addition, a basic music synthesis language (Music56000) has been written in assembly code. On top of this, a symbolic compiler (PatchWork) has been developed to enable algorithms which run in these processors to be created graphically. And finally, a number of efficient time domain numerical models have been developed to enable the construction, simulation, control, and synthesis of many musical acoustics systems in real time on these processors. Specifically, assembly language models for cylindrical and conical horn sections, dissipative losses, tone holes, bells, and a number of linear and nonlinear boundary conditions have been developed.

A method for obtaining a statistically stationary turbulent free shear flow

NASA Technical Reports Server (NTRS)

Timson, Stephen F.; Lele, S. K.; Moser, R. D.

1994-01-01

The long-term goal of the current research is the study of Large-Eddy Simulation (LES) as a tool for aeroacoustics. New algorithms and developments in computer hardware are making possible a new generation of tools for aeroacoustic predictions, which rely on the physics of the flow rather than empirical knowledge. LES, in conjunction with an acoustic analogy, holds the promise of predicting the statistics of noise radiated to the far-field of a turbulent flow. LES's predictive ability will be tested through extensive comparison of acoustic predictions based on a Direct Numerical Simulation (DNS) and LES of the same flow, as well as a priori testing of DNS results. The method presented here is aimed at allowing simulation of a turbulent flow field that is both simple and amenable to acoustic predictions. A free shear flow is homogeneous in both the streamwise and spanwise directions and which is statistically stationary will be simulated using equations based on the Navier-Stokes equations with a small number of added terms. Studying a free shear flow eliminates the need to consider flow-surface interactions as an acoustic source. The homogeneous directions and the flow's statistically stationary nature greatly simplify the application of an acoustic analogy.

Characterization and Modeling of Nonfilamentary Ta/TaOx/TiO2/Ti Analog Synaptic Device

PubMed Central

Wang, Yu-Fen; Lin, Yen-Chuan; Wang, I-Ting; Lin, Tzu-Ping; Hou, Tuo-Hung

2015-01-01

A two-terminal analog synaptic device that precisely emulates biological synaptic features is expected to be a critical component for future hardware-based neuromorphic computing. Typical synaptic devices based on filamentary resistive switching face severe limitations on the implementation of concurrent inhibitory and excitatory synapses with low conductance and state fluctuation. For overcoming these limitations, we propose a Ta/TaOx/TiO2/Ti device with superior analog synaptic features. A physical simulation based on the homogeneous (nonfilamentary) barrier modulation induced by oxygen ion migration accurately reproduces various DC and AC evolutions of synaptic states, including the spike-timing-dependent plasticity and paired-pulse facilitation. Furthermore, a physics-based compact model for facilitating circuit-level design is proposed on the basis of the general definition of memristor devices. This comprehensive experimental and theoretical study of the promising electronic synapse can facilitate realizing large-scale neuromorphic systems. PMID:25955658

The design of radiation-hardened ICs for space - A compendium of approaches

NASA Technical Reports Server (NTRS)

Kerns, Sherra E.; Shafer, B. D; Rockett, L. R., Jr.; Pridmore, J. S.; Berndt, D. F.

1988-01-01

Several technologies, including bulk and epi CMOS, CMOS/SOI-SOS (silicon-on-insulator-silicon-on-sapphire), CML (current-mode logic), ECL (emitter-coupled logic), analog bipolar (JI, single-poly DI, and SOI) and GaAs E/D (enhancement/depletion) heterojunction MESFET, are discussed. The discussion includes the direct effects of space radiation on microelectronic materials and devices, how these effects are evidenced in circuit and device design parameter variations, the particular effects of most significance to each functional class of circuit, specific techniques for hardening high-speed circuits, design examples for integrated systems, including operational amplifiers and A/D (analog/digital) converters, and the computer simulation of radiation effects on microelectronic ISs.

In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations.

PubMed

Gao, Xiaodong; Han, Liping; Ren, Yujie

2016-05-05

Checkpoint kinase 1 (Chk1) is an important serine/threonine kinase with a self-protection function. The combination of Chk1 inhibitors and anti-cancer drugs can enhance the selectivity of tumor therapy. In this work, a set of 1,7-diazacarbazole analogs were identified as potent Chk1 inhibitors through a series of computer-aided drug design processes, including three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling, molecular docking, and molecular dynamics simulations. The optimal QSAR models showed significant cross-validated correlation q² values (0.531, 0.726), fitted correlation r² coefficients (higher than 0.90), and standard error of prediction (less than 0.250). These results suggested that the developed models possess good predictive ability. Moreover, molecular docking and molecular dynamics simulations were applied to highlight the important interactions between the ligand and the Chk1 receptor protein. This study shows that hydrogen bonding and electrostatic forces are key interactions that confer bioactivity.

TU-H-CAMPUS-IeP1-01: Bias and Computational Efficiency of Variance Reduction Methods for the Monte Carlo Simulation of Imaging Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharma, D; Badano, A; Sempau, J

Purpose: Variance reduction techniques (VRTs) are employed in Monte Carlo simulations to obtain estimates with reduced statistical uncertainty for a given simulation time. In this work, we study the bias and efficiency of a VRT for estimating the response of imaging detectors. Methods: We implemented Directed Sampling (DS), preferentially directing a fraction of emitted optical photons directly towards the detector by altering the isotropic model. The weight of each optical photon is appropriately modified to maintain simulation estimates unbiased. We use a Monte Carlo tool called fastDETECT2 (part of the hybridMANTIS open-source package) for optical transport, modified for VRT. Themore » weight of each photon is calculated as the ratio of original probability (no VRT) and the new probability for a particular direction. For our analysis of bias and efficiency, we use pulse height spectra, point response functions, and Swank factors. We obtain results for a variety of cases including analog (no VRT, isotropic distribution), and DS with 0.2 and 0.8 optical photons directed towards the sensor plane. We used 10,000, 25-keV primaries. Results: The Swank factor for all cases in our simplified model converged fast (within the first 100 primaries) to a stable value of 0.9. The root mean square error per pixel for DS VRT for the point response function between analog and VRT cases was approximately 5e-4. Conclusion: Our preliminary results suggest that DS VRT does not affect the estimate of the mean for the Swank factor. Our findings indicate that it may be possible to design VRTs for imaging detector simulations to increase computational efficiency without introducing bias.« less

Bypassing the malfunction junction in warm dense matter simulations

NASA Astrophysics Data System (ADS)

Cangi, Attila; Pribram-Jones, Aurora

2015-03-01

Simulation of warm dense matter requires computational methods that capture both quantum and classical behavior efficiently under high-temperature and high-density conditions. The state-of-the-art approach to model electrons and ions under those conditions is density functional theory molecular dynamics, but this method's computational cost skyrockets as temperatures and densities increase. We propose finite-temperature potential functional theory as an in-principle-exact alternative that suffers no such drawback. In analogy to the zero-temperature theory developed previously, we derive an orbital-free free energy approximation through a coupling-constant formalism. Our density approximation and its associated free energy approximation demonstrate the method's accuracy and efficiency. A.C. has been partially supported by NSF Grant CHE-1112442. A.P.J. is supported by DOE Grant DE-FG02-97ER25308.

Autonomous, Computer-Based Behavioral Health Countermeasure Evaluation at HI-SEAS Mars Analog.

PubMed

Anderson, Allison P; Fellows, Abigail M; Binsted, Kim A; Hegel, Mark T; Buckey, Jay C

Living in an isolated, confined environment (ICE) can induce conflict, stress, and depression. Computer-based behavioral health countermeasures are appealing for training and treatment in ICEs because they provide confidentiality and do not require communication with the outside environment. We evaluated the Virtual Space Station (VSS), a suite of interactive computer-delivered psychological training and treatment programs, at the Hawaii Space Exploration Analog and Simulation (HI-SEAS) III expedition. Six subjects (3 male, 3 female) spent 8 mo in group-isolation and used the Conflict, Stress, and Depression modules in the VSS. Survey evaluations, data collected within the program, and postdeployment interviews were collected. This crew dealt with behavioral health issues common to ICEs. The VSS proved to be a valuable resource and was used both as intended, and in unanticipated ways, to help maintain behavioral health. The Conflict and Stress Modules were rated as highly acceptable (1.8 on a 7-point Likert scale). The crew identified a total of 13 stressors and worked on 9 problems through the VSS. Opinions about the modules were highly individualized. Crewmembers identified exercises in the VSS that were applicable and not applicable to their needs. Additional content to improve the program was identified. Autonomous, confidential training and treatment for behavioral health issues will need to be a critical component of long duration spaceflight travel. This work provides an evaluation of such a tool in a relevant ICE. Anderson AP, Fellows AM, Binsted KA, Hegel MT, Buckey JC. Autonomous, computer-based behavioral health countermeasure evaluation at HI-SEAS Mars analog. Aerosp Med Hum Perform. 2016; 87(11):912-920.

Model implementation for dynamic computation of system cost

NASA Astrophysics Data System (ADS)

Levri, J.; Vaccari, D.

The Advanced Life Support (ALS) Program metric is the ratio of the equivalent system mass (ESM) of a mission based on International Space Station (ISS) technology to the ESM of that same mission based on ALS technology. ESM is a mission cost analog that converts the volume, power, cooling and crewtime requirements of a mission into mass units to compute an estimate of the life support system emplacement cost. Traditionally, ESM has been computed statically, using nominal values for system sizing. However, computation of ESM with static, nominal sizing estimates cannot capture the peak sizing requirements driven by system dynamics. In this paper, a dynamic model for a near-term Mars mission is described. The model is implemented in Matlab/Simulink' for the purpose of dynamically computing ESM. This paper provides a general overview of the crew, food, biomass, waste, water and air blocks in the Simulink' model. Dynamic simulations of the life support system track mass flow, volume and crewtime needs, as well as power and cooling requirement profiles. The mission's ESM is computed, based upon simulation responses. Ultimately, computed ESM values for various system architectures will feed into an optimization search (non-derivative) algorithm to predict parameter combinations that result in reduced objective function values.

Computer Analogies: Teaching Molecular Biology and Ecology.

ERIC Educational Resources Information Center

Rice, Stanley; McArthur, John

2002-01-01

Suggests that computer science analogies can aid the understanding of gene expression, including the storage of genetic information on chromosomes. Presents a matrix of biology and computer science concepts. (DDR)

Investigation of differences in the binding affinities of two analogous ligands for untagged and tagged p38 kinase using thermodynamic integration MD simulation.

PubMed

Sun, Ying-Chieh; Hsu, Wen-Chi; Hsu, Chia-Jen; Chang, Chia-Ming; Cheng, Kai-Hsiang

2015-11-01

Thermodynamic integration (TI) molecular dynamics (MD) simulations for the binding of a pair of a reference ("ref") ligand and an analogous ("analog") ligand to either tagged (with six extra residues at the N-terminus) or untagged p38 kinase proteins were carried out in order to probe how the binding affinity is influenced by the presence or absence of the peptide tag in p38 kinase. This possible effect of protein length on the binding affinity of a ligand-which is seldom addressed in the literature-is important because, even when two labs claim to have performed experiments with the same protein, they may actually have studied variants of the same protein with different lengths because they applied different protein expression conditions/procedures. Thus, if we wanted to compare ligand binding affinities measured in the two labs, it would be necessary to account for any variation in ligand binding affinity with protein length. The pair of ligand-p38 kinase complexes examined in this work (pdb codes: 3d7z and 3lhj, respectively) were ideal for investigating this effect. The experimentally determined binding energy for the ref ligand with the untagged p38 kinase was -10.9 kcal mol(-1), while that for the analog ligand with the tagged p38 kinase was -11.9 kcal mol(-1). The present TI-MD simulation of the mutation of the ref ligand into the analog ligand while the ligand is bound to the untagged p38 kinase predicted that the binding affinity of the analog ligand is 2.0 kcal mol(-1) greater than that of the ref ligand. A similar simulation also indicated that the same was true for ligand binding to the tagged protein, but in this case the binding affinity for the analog ligand is 2.5 kcal mol(-1) larger than that for the ref ligand. These results therefore suggest that the presence of the peptide tag on p38 kinase increased the difference in the binding energies of the ligands by a small amount of 0.5 kcal mol(-1). This result supports the assumption that the presence of a peptide tag has only a minor effect on ΔG values. The error bars in the computed ΔG values were then estimated via confidence interval analysis and a time autocorrelation function for the quantity dV/dλ. The estimated correlation time was ~0.5 ps and the error bar in the ΔG values estimated using nanosecond-scale simulations was ±0.3 kcal mol(-1) at a confidence level of 95%. These predicted results can be verified in future experiments and should prove useful in subsequent similar studies. Graphical Abstract Thermodynamic cycles for binding of two analogous ligands with untagged and tagged p38 kinases and associated Gibbs free energy.

An Analog Computer for Electronic Engineering Education

ERIC Educational Resources Information Center

Fitch, A. L.; Iu, H. H. C.; Lu, D. D. C.

2011-01-01

This paper describes a compact analog computer and proposes its use in electronic engineering teaching laboratories to develop student understanding of applications in analog electronics, electronic components, engineering mathematics, control engineering, safe laboratory and workshop practices, circuit construction, testing, and maintenance. The…

Evaluation of Airframe Noise Reduction Concepts via Simulations Using a Lattice Boltzmann Approach

NASA Technical Reports Server (NTRS)

Fares, Ehab; Casalino, Damiano; Khorrami, Mehdi R.

2015-01-01

Unsteady computations are presented for a high-fidelity, 18% scale, semi-span Gulfstream aircraft model in landing configuration, i.e. flap deflected at 39 degree and main landing gear deployed. The simulations employ the lattice Boltzmann solver PowerFLOW® to simultaneously capture the flow physics and acoustics in the near field. Sound propagation to the far field is obtained using a Ffowcs Williams and Hawkings acoustic analogy approach. In addition to the baseline geometry, which was presented previously, various noise reduction concepts for the flap and main landing gear are simulated. In particular, care is taken to fully resolve the complex geometrical details associated with these concepts in order to capture the resulting intricate local flow field thus enabling accurate prediction of their acoustic behavior. To determine aeroacoustic performance, the farfield noise predicted with the concepts applied is compared to high-fidelity simulations of the untreated baseline configurations. To assess the accuracy of the computed results, the aerodynamic and aeroacoustic impact of the noise reduction concepts is evaluated numerically and compared to experimental results for the same model. The trends and effectiveness of the simulated noise reduction concepts compare well with measured values and demonstrate that the computational approach is capable of capturing the primary effects of the acoustic treatment on a full aircraft model.

Xyce parallel electronic simulator users guide, version 6.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keiter, Eric R; Mei, Ting; Russo, Thomas V.

This manual describes the use of the Xyce Parallel Electronic Simulator. Xyce has been designed as a SPICE-compatible, high-performance analog circuit simulator, and has been written to support the simulation needs of the Sandia National Laboratories electrical designers. This development has focused on improving capability over the current state-of-the-art in the following areas; Capability to solve extremely large circuit problems by supporting large-scale parallel computing platforms (up to thousands of processors). This includes support for most popular parallel and serial computers; A differential-algebraic-equation (DAE) formulation, which better isolates the device model package from solver algorithms. This allows one to developmore » new types of analysis without requiring the implementation of analysis-specific device models; Device models that are specifically tailored to meet Sandia's needs, including some radiationaware devices (for Sandia users only); and Object-oriented code design and implementation using modern coding practices. Xyce is a parallel code in the most general sense of the phrase-a message passing parallel implementation-which allows it to run efficiently a wide range of computing platforms. These include serial, shared-memory and distributed-memory parallel platforms. Attention has been paid to the specific nature of circuit-simulation problems to ensure that optimal parallel efficiency is achieved as the number of processors grows.« less

Xyce parallel electronic simulator users' guide, Version 6.0.1.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keiter, Eric R; Mei, Ting; Russo, Thomas V.

This manual describes the use of the Xyce Parallel Electronic Simulator. Xyce has been designed as a SPICE-compatible, high-performance analog circuit simulator, and has been written to support the simulation needs of the Sandia National Laboratories electrical designers. This development has focused on improving capability over the current state-of-the-art in the following areas: Capability to solve extremely large circuit problems by supporting large-scale parallel computing platforms (up to thousands of processors). This includes support for most popular parallel and serial computers. A differential-algebraic-equation (DAE) formulation, which better isolates the device model package from solver algorithms. This allows one to developmore » new types of analysis without requiring the implementation of analysis-specific device models. Device models that are specifically tailored to meet Sandias needs, including some radiationaware devices (for Sandia users only). Object-oriented code design and implementation using modern coding practices. Xyce is a parallel code in the most general sense of the phrase a message passing parallel implementation which allows it to run efficiently a wide range of computing platforms. These include serial, shared-memory and distributed-memory parallel platforms. Attention has been paid to the specific nature of circuit-simulation problems to ensure that optimal parallel efficiency is achieved as the number of processors grows.« less

Xyce parallel electronic simulator users guide, version 6.0.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keiter, Eric R; Mei, Ting; Russo, Thomas V.

This manual describes the use of the Xyce Parallel Electronic Simulator. Xyce has been designed as a SPICE-compatible, high-performance analog circuit simulator, and has been written to support the simulation needs of the Sandia National Laboratories electrical designers. This development has focused on improving capability over the current state-of-the-art in the following areas: Capability to solve extremely large circuit problems by supporting large-scale parallel computing platforms (up to thousands of processors). This includes support for most popular parallel and serial computers. A differential-algebraic-equation (DAE) formulation, which better isolates the device model package from solver algorithms. This allows one to developmore » new types of analysis without requiring the implementation of analysis-specific device models. Device models that are specifically tailored to meet Sandias needs, including some radiationaware devices (for Sandia users only). Object-oriented code design and implementation using modern coding practices. Xyce is a parallel code in the most general sense of the phrase a message passing parallel implementation which allows it to run efficiently a wide range of computing platforms. These include serial, shared-memory and distributed-memory parallel platforms. Attention has been paid to the specific nature of circuit-simulation problems to ensure that optimal parallel efficiency is achieved as the number of processors grows.« less

Lewis Research Center studies of multiple large wind turbine generators on a utility network

NASA Technical Reports Server (NTRS)

Gilbert, L. J.; Triezenberg, D. M.

1979-01-01

A NASA-Lewis program to study the anticipated performance of a wind turbine generator farm on an electric utility network is surveyed. The paper describes the approach of the Lewis Wind Energy Project Office to developing analysis capabilities in the area of wind turbine generator-utility network computer simulations. Attention is given to areas such as, the Lewis Purdue hybrid simulation, an independent stability study, DOE multiunit plant study, and the WEST simulator. Also covered are the Lewis mod-2 simulation including analog simulation of a two wind turbine system and comparison with Boeing simulation results, and gust response of a two machine model. Finally future work to be done is noted and it is concluded that the study shows little interaction between the generators and between the generators and the bus.

Simulation and analysis of a model dinoflagellate predator-prey system

NASA Astrophysics Data System (ADS)

Mazzoleni, M. J.; Antonelli, T.; Coyne, K. J.; Rossi, L. F.

2015-12-01

This paper analyzes the dynamics of a model dinoflagellate predator-prey system and uses simulations to validate theoretical and experimental studies. A simple model for predator-prey interactions is derived by drawing upon analogies from chemical kinetics. This model is then modified to account for inefficiencies in predation. Simulation results are shown to closely match the model predictions. Additional simulations are then run which are based on experimental observations of predatory dinoflagellate behavior, and this study specifically investigates how the predatory dinoflagellate Karlodinium veneficum uses toxins to immobilize its prey and increase its feeding rate. These simulations account for complex dynamics that were not included in the basic models, and the results from these computational simulations closely match the experimentally observed predatory behavior of K. veneficum and reinforce the notion that predatory dinoflagellates utilize toxins to increase their feeding rate.

Writing and compiling code into biochemistry.

PubMed

Shea, Adam; Fett, Brian; Riedel, Marc D; Parhi, Keshab

2010-01-01

This paper presents a methodology for translating iterative arithmetic computation, specified as high-level programming constructs, into biochemical reactions. From an input/output specification, we generate biochemical reactions that produce output quantities of proteins as a function of input quantities performing operations such as addition, subtraction, and scalar multiplication. Iterative constructs such as "while" loops and "for" loops are implemented by transferring quantities between protein types, based on a clocking mechanism. Synthesis first is performed at a conceptual level, in terms of abstract biochemical reactions - a task analogous to high-level program compilation. Then the results are mapped onto specific biochemical reactions selected from libraries - a task analogous to machine language compilation. We demonstrate our approach through the compilation of a variety of standard iterative functions: multiplication, exponentiation, discrete logarithms, raising to a power, and linear transforms on time series. The designs are validated through transient stochastic simulation of the chemical kinetics. We are exploring DNA-based computation via strand displacement as a possible experimental chassis.

Direct-coupled microcomputer-based building emulator for building energy management and control systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lam, H.N.

1999-07-01

In this paper, the development and implementation of a direct-coupled building emulator for a building energy management and control system (EMCS) is presented. The building emulator consists of a microcomputer and a computer model of an air-conditioning system implemented in a modular dynamic simulation software package for direct-coupling to an EMCS, without using analog-to-digital and digital-to-analog converters. The building emulator can be used to simulate in real time the behavior of the air-conditioning system under a given operating environment and subject to a given usage pattern. Software modules for data communication, graphical display, dynamic data exchange, and synchronization of simulationmore » outputs with real time have been developed to achieve direct digital data transfer between the building emulator and a commercial EMCS. Based on the tests conducted, the validity of the building emulator has been established and the proportional-plus-integral control function of the EMCS assessed.« less

Large-Scale Simulations of Plastic Neural Networks on Neuromorphic Hardware

PubMed Central

Knight, James C.; Tully, Philip J.; Kaplan, Bernhard A.; Lansner, Anders; Furber, Steve B.

2016-01-01

SpiNNaker is a digital, neuromorphic architecture designed for simulating large-scale spiking neural networks at speeds close to biological real-time. Rather than using bespoke analog or digital hardware, the basic computational unit of a SpiNNaker system is a general-purpose ARM processor, allowing it to be programmed to simulate a wide variety of neuron and synapse models. This flexibility is particularly valuable in the study of biological plasticity phenomena. A recently proposed learning rule based on the Bayesian Confidence Propagation Neural Network (BCPNN) paradigm offers a generic framework for modeling the interaction of different plasticity mechanisms using spiking neurons. However, it can be computationally expensive to simulate large networks with BCPNN learning since it requires multiple state variables for each synapse, each of which needs to be updated every simulation time-step. We discuss the trade-offs in efficiency and accuracy involved in developing an event-based BCPNN implementation for SpiNNaker based on an analytical solution to the BCPNN equations, and detail the steps taken to fit this within the limited computational and memory resources of the SpiNNaker architecture. We demonstrate this learning rule by learning temporal sequences of neural activity within a recurrent attractor network which we simulate at scales of up to 2.0 × 104 neurons and 5.1 × 107 plastic synapses: the largest plastic neural network ever to be simulated on neuromorphic hardware. We also run a comparable simulation on a Cray XC-30 supercomputer system and find that, if it is to match the run-time of our SpiNNaker simulation, the super computer system uses approximately 45× more power. This suggests that cheaper, more power efficient neuromorphic systems are becoming useful discovery tools in the study of plasticity in large-scale brain models. PMID:27092061

COED Transactions, Vol. X, No. 9, September 1978. Use of the Analog/Hybrid Computer in Boundary Layer and Convection Studies.

ERIC Educational Resources Information Center

Mitchell, Eugene E., Ed.

In certain boundary layer or natural convection work, where a similarity transformation is valid, the equations can be reduced to a set of nonlinear ordinary differential equations. They are therefore well-suited to a fast solution on an analog/hybrid computer. This paper illustrates such usage of the analog/hybrid computer by a set of…

A subthreshold aVLSI implementation of the Izhikevich simple neuron model.

PubMed

Rangan, Venkat; Ghosh, Abhishek; Aparin, Vladimir; Cauwenberghs, Gert

2010-01-01

We present a circuit architecture for compact analog VLSI implementation of the Izhikevich neuron model, which efficiently describes a wide variety of neuron spiking and bursting dynamics using two state variables and four adjustable parameters. Log-domain circuit design utilizing MOS transistors in subthreshold results in high energy efficiency, with less than 1pJ of energy consumed per spike. We also discuss the effects of parameter variations on the dynamics of the equations, and present simulation results that replicate several types of neural dynamics. The low power operation and compact analog VLSI realization make the architecture suitable for human-machine interface applications in neural prostheses and implantable bioelectronics, as well as large-scale neural emulation tools for computational neuroscience.

Digital-analog quantum simulation of generalized Dicke models with superconducting circuits

NASA Astrophysics Data System (ADS)

Lamata, Lucas

2017-03-01

We propose a digital-analog quantum simulation of generalized Dicke models with superconducting circuits, including Fermi- Bose condensates, biased and pulsed Dicke models, for all regimes of light-matter coupling. We encode these classes of problems in a set of superconducting qubits coupled with a bosonic mode implemented by a transmission line resonator. Via digital-analog techniques, an efficient quantum simulation can be performed in state-of-the-art circuit quantum electrodynamics platforms, by suitable decomposition into analog qubit-bosonic blocks and collective single-qubit pulses through digital steps. Moreover, just a single global analog block would be needed during the whole protocol in most of the cases, superimposed with fast periodic pulses to rotate and detune the qubits. Therefore, a large number of digital steps may be attained with this approach, providing a reduced digital error. Additionally, the number of gates per digital step does not grow with the number of qubits, rendering the simulation efficient. This strategy paves the way for the scalable digital-analog quantum simulation of many-body dynamics involving bosonic modes and spin degrees of freedom with superconducting circuits.

Digital-analog quantum simulation of generalized Dicke models with superconducting circuits

PubMed Central

Lamata, Lucas

2017-01-01

We propose a digital-analog quantum simulation of generalized Dicke models with superconducting circuits, including Fermi- Bose condensates, biased and pulsed Dicke models, for all regimes of light-matter coupling. We encode these classes of problems in a set of superconducting qubits coupled with a bosonic mode implemented by a transmission line resonator. Via digital-analog techniques, an efficient quantum simulation can be performed in state-of-the-art circuit quantum electrodynamics platforms, by suitable decomposition into analog qubit-bosonic blocks and collective single-qubit pulses through digital steps. Moreover, just a single global analog block would be needed during the whole protocol in most of the cases, superimposed with fast periodic pulses to rotate and detune the qubits. Therefore, a large number of digital steps may be attained with this approach, providing a reduced digital error. Additionally, the number of gates per digital step does not grow with the number of qubits, rendering the simulation efficient. This strategy paves the way for the scalable digital-analog quantum simulation of many-body dynamics involving bosonic modes and spin degrees of freedom with superconducting circuits. PMID:28256559

An Overview of Computational Aeroacoustic Modeling at NASA Langley

NASA Technical Reports Server (NTRS)

Lockard, David P.

2001-01-01

The use of computational techniques in the area of acoustics is known as computational aeroacoustics and has shown great promise in recent years. Although an ultimate goal is to use computational simulations as a virtual wind tunnel, the problem is so complex that blind applications of traditional algorithms are typically unable to produce acceptable results. The phenomena of interest are inherently unsteady and cover a wide range of frequencies and amplitudes. Nonetheless, with appropriate simplifications and special care to resolve specific phenomena, currently available methods can be used to solve important acoustic problems. These simulations can be used to complement experiments, and often give much more detailed information than can be obtained in a wind tunnel. The use of acoustic analogy methods to inexpensively determine far-field acoustics from near-field unsteadiness has greatly reduced the computational requirements. A few examples of current applications of computational aeroacoustics at NASA Langley are given. There remains a large class of problems that require more accurate and efficient methods. Research to develop more advanced methods that are able to handle the geometric complexity of realistic problems using block-structured and unstructured grids are highlighted.

Stored program concept for analog computers

NASA Technical Reports Server (NTRS)

Hannauer, G., III; Patmore, J. R.

1971-01-01

Optimization of three-stage matrices, modularization, and black boxes design techniques provides for automatically interconnecting computing component inputs and outputs in general purpose analog computer. Design also produces relatively inexpensive and less complex automatic patching system.

Study of G-S/D underlap for enhanced analog performance and RF/circuit analysis of UTB InAs-OI-Si MOSFET using NQS small signal model

NASA Astrophysics Data System (ADS)

Maity, Subir Kumar; Pandit, Soumya

2017-01-01

InGaAs (and its variant) appears to be a promising channel material for high-performance, low-power scaled CMOS applications due to its excellent carrier transport properties. However, MOS transistors made of this suffer from poor electrostatic integrity. In this work, we consider an underlap ultra thin body (UTB) InAs-on-Insulator n-channel MOS transistor, and study the effect of varying the gate-source/drain (G-S/D) underlap length on the analog performance of the device with the help of technology computer-aided design (TCAD) simulation, calibrated with Schrodinger-Poisson solver and experimental results. The underlap technique improves the gate electrostatic integrity which in turn improves the analog performance. We develop a non-quasi-static (NQS) small signal equivalent circuit model of the device which is used for study of the RF performance. With increase of the underlap length, the unity gain cut-off frequency degrades and the maximum oscillation frequency improves beyond a certain value of the underlap length. We further study the gain-frequency response of a common source amplifier using the NQS model, through SPICE simulation and observe that the voltage gain and the gain bandwidth improves.

Fixed forced detection for fast SPECT Monte-Carlo simulation

NASA Astrophysics Data System (ADS)

Cajgfinger, T.; Rit, S.; Létang, J. M.; Halty, A.; Sarrut, D.

2018-03-01

Monte-Carlo simulations of SPECT images are notoriously slow to converge due to the large ratio between the number of photons emitted and detected in the collimator. This work proposes a method to accelerate the simulations based on fixed forced detection (FFD) combined with an analytical response of the detector. FFD is based on a Monte-Carlo simulation but forces the detection of a photon in each detector pixel weighted by the probability of emission (or scattering) and transmission to this pixel. The method was evaluated with numerical phantoms and on patient images. We obtained differences with analog Monte Carlo lower than the statistical uncertainty. The overall computing time gain can reach up to five orders of magnitude. Source code and examples are available in the Gate V8.0 release.

Fixed forced detection for fast SPECT Monte-Carlo simulation.

PubMed

Cajgfinger, T; Rit, S; Létang, J M; Halty, A; Sarrut, D

2018-03-02

Monte-Carlo simulations of SPECT images are notoriously slow to converge due to the large ratio between the number of photons emitted and detected in the collimator. This work proposes a method to accelerate the simulations based on fixed forced detection (FFD) combined with an analytical response of the detector. FFD is based on a Monte-Carlo simulation but forces the detection of a photon in each detector pixel weighted by the probability of emission (or scattering) and transmission to this pixel. The method was evaluated with numerical phantoms and on patient images. We obtained differences with analog Monte Carlo lower than the statistical uncertainty. The overall computing time gain can reach up to five orders of magnitude. Source code and examples are available in the Gate V8.0 release.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bolme, David S; Mikkilineni, Aravind K; Rose, Derek C

Analog computational circuits have been demonstrated to provide substantial improvements in power and speed relative to digital circuits, especially for applications requiring extreme parallelism but only modest precision. Deep machine learning is one such area and stands to benefit greatly from analog and mixed-signal implementations. However, even at modest precisions, offsets and non-linearity can degrade system performance. Furthermore, in all but the simplest systems, it is impossible to directly measure the intermediate outputs of all sub-circuits. The result is that circuit designers are unable to accurately evaluate the non-idealities of computational circuits in-situ and are therefore unable to fully utilizemore » measurement results to improve future designs. In this paper we present a technique to use deep learning frameworks to model physical systems. Recently developed libraries like TensorFlow make it possible to use back propagation to learn parameters in the context of modeling circuit behavior. Offsets and scaling errors can be discovered even for sub-circuits that are deeply embedded in a computational system and not directly observable. The learned parameters can be used to refine simulation methods or to identify appropriate compensation strategies. We demonstrate the framework using a mixed-signal convolution operator as an example circuit.« less

Bifurcation-based adiabatic quantum computation with a nonlinear oscillator network.

PubMed

Goto, Hayato

2016-02-22

The dynamics of nonlinear systems qualitatively change depending on their parameters, which is called bifurcation. A quantum-mechanical nonlinear oscillator can yield a quantum superposition of two oscillation states, known as a Schrödinger cat state, via quantum adiabatic evolution through its bifurcation point. Here we propose a quantum computer comprising such quantum nonlinear oscillators, instead of quantum bits, to solve hard combinatorial optimization problems. The nonlinear oscillator network finds optimal solutions via quantum adiabatic evolution, where nonlinear terms are increased slowly, in contrast to conventional adiabatic quantum computation or quantum annealing, where quantum fluctuation terms are decreased slowly. As a result of numerical simulations, it is concluded that quantum superposition and quantum fluctuation work effectively to find optimal solutions. It is also notable that the present computer is analogous to neural computers, which are also networks of nonlinear components. Thus, the present scheme will open new possibilities for quantum computation, nonlinear science, and artificial intelligence.

Bifurcation-based adiabatic quantum computation with a nonlinear oscillator network

NASA Astrophysics Data System (ADS)

Goto, Hayato

2016-02-01

The dynamics of nonlinear systems qualitatively change depending on their parameters, which is called bifurcation. A quantum-mechanical nonlinear oscillator can yield a quantum superposition of two oscillation states, known as a Schrödinger cat state, via quantum adiabatic evolution through its bifurcation point. Here we propose a quantum computer comprising such quantum nonlinear oscillators, instead of quantum bits, to solve hard combinatorial optimization problems. The nonlinear oscillator network finds optimal solutions via quantum adiabatic evolution, where nonlinear terms are increased slowly, in contrast to conventional adiabatic quantum computation or quantum annealing, where quantum fluctuation terms are decreased slowly. As a result of numerical simulations, it is concluded that quantum superposition and quantum fluctuation work effectively to find optimal solutions. It is also notable that the present computer is analogous to neural computers, which are also networks of nonlinear components. Thus, the present scheme will open new possibilities for quantum computation, nonlinear science, and artificial intelligence.

Numerical simulation of a helical shape electric arc in the external axial magnetic field

NASA Astrophysics Data System (ADS)

Urusov, R. M.; Urusova, I. R.

2016-10-01

Within the frameworks of non-stationary three-dimensional mathematical model, in approximation of a partial local thermodynamic equilibrium, a numerical calculation was made of characteristics of DC electric arc burning in a cylindrical channel in the uniform external axial magnetic field. The method of numerical simulation of the arc of helical shape in a uniform external axial magnetic field was proposed. This method consists in that that in the computational algorithm, a "scheme" analog of fluctuations for electrons temperature is supplemented. The "scheme" analogue of fluctuations increases a weak numerical asymmetry of electrons temperature distribution, which occurs randomly in the course of computing. This asymmetry can be "picked up" by the external magnetic field that continues to increase up to a certain value, which is sufficient for the formation of helical structure of the arc column. In the absence of fluctuations in the computational algorithm, the arc column in the external axial magnetic field maintains cylindrical axial symmetry, and a helical form of the arc is not observed.

METHOD AND APPARATUS FOR DETERMINING CHARGED PARTICLE MOTION

DOEpatents

Kerns, Q.A.

1959-08-01

An analog system for determining the motion of charged particles in three dimensional electrical fields is described. A model electrode structure is formed and potentials are applied to the electrodes to provide an analog of the field which is to be studied. To simulate charged particles within the model, conducting spheres are placed at points from which particle motion is to be traced. To free the spheres from gravitational attraction in order that they will be electrostatically accelerated through the model, the apparatus is suspended and dropped. During the pericd that the model is dropping the spheres move through the electrcde structure with a motion corresponding to that of particles in the real system. The model is photographed in the course of falling so that the instantaneous position of the spheres within the simulated field at selected times may be observed and measured. The device thus gives data of particles in the real system. The model is photographed in the course of falling so that the instantaneous position of the spheres within the simulated field at selected times may be observed and measured. The device thus gives data which frequently can otherwise be obtained only with a digital computer.

Model Checking Techniques for Assessing Functional Form Specifications in Censored Linear Regression Models.

PubMed

León, Larry F; Cai, Tianxi

2012-04-01

In this paper we develop model checking techniques for assessing functional form specifications of covariates in censored linear regression models. These procedures are based on a censored data analog to taking cumulative sums of "robust" residuals over the space of the covariate under investigation. These cumulative sums are formed by integrating certain Kaplan-Meier estimators and may be viewed as "robust" censored data analogs to the processes considered by Lin, Wei & Ying (2002). The null distributions of these stochastic processes can be approximated by the distributions of certain zero-mean Gaussian processes whose realizations can be generated by computer simulation. Each observed process can then be graphically compared with a few realizations from the Gaussian process. We also develop formal test statistics for numerical comparison. Such comparisons enable one to assess objectively whether an apparent trend seen in a residual plot reects model misspecification or natural variation. We illustrate the methods with a well known dataset. In addition, we examine the finite sample performance of the proposed test statistics in simulation experiments. In our simulation experiments, the proposed test statistics have good power of detecting misspecification while at the same time controlling the size of the test.

A physics-motivated Centroidal Voronoi Particle domain decomposition method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fu, Lin, E-mail: lin.fu@tum.de; Hu, Xiangyu Y., E-mail: xiangyu.hu@tum.de; Adams, Nikolaus A., E-mail: nikolaus.adams@tum.de

2017-04-15

In this paper, we propose a novel domain decomposition method for large-scale simulations in continuum mechanics by merging the concepts of Centroidal Voronoi Tessellation (CVT) and Voronoi Particle dynamics (VP). The CVT is introduced to achieve a high-level compactness of the partitioning subdomains by the Lloyd algorithm which monotonically decreases the CVT energy. The number of computational elements between neighboring partitioning subdomains, which scales the communication effort for parallel simulations, is optimized implicitly as the generated partitioning subdomains are convex and simply connected with small aspect-ratios. Moreover, Voronoi Particle dynamics employing physical analogy with a tailored equation of state ismore » developed, which relaxes the particle system towards the target partition with good load balance. Since the equilibrium is computed by an iterative approach, the partitioning subdomains exhibit locality and the incremental property. Numerical experiments reveal that the proposed Centroidal Voronoi Particle (CVP) based algorithm produces high-quality partitioning with high efficiency, independently of computational-element types. Thus it can be used for a wide range of applications in computational science and engineering.« less

A physics-motivated Centroidal Voronoi Particle domain decomposition method

NASA Astrophysics Data System (ADS)

Fu, Lin; Hu, Xiangyu Y.; Adams, Nikolaus A.

2017-04-01

In this paper, we propose a novel domain decomposition method for large-scale simulations in continuum mechanics by merging the concepts of Centroidal Voronoi Tessellation (CVT) and Voronoi Particle dynamics (VP). The CVT is introduced to achieve a high-level compactness of the partitioning subdomains by the Lloyd algorithm which monotonically decreases the CVT energy. The number of computational elements between neighboring partitioning subdomains, which scales the communication effort for parallel simulations, is optimized implicitly as the generated partitioning subdomains are convex and simply connected with small aspect-ratios. Moreover, Voronoi Particle dynamics employing physical analogy with a tailored equation of state is developed, which relaxes the particle system towards the target partition with good load balance. Since the equilibrium is computed by an iterative approach, the partitioning subdomains exhibit locality and the incremental property. Numerical experiments reveal that the proposed Centroidal Voronoi Particle (CVP) based algorithm produces high-quality partitioning with high efficiency, independently of computational-element types. Thus it can be used for a wide range of applications in computational science and engineering.

Quantum Analogies in the Interaction between Acoustic Waves and Bubble Clouds

NASA Astrophysics Data System (ADS)

Parrales, Miguel A.; Rodriguez-Rodriguez, Javier

2014-11-01

Analogies between quantum mechanical and acoustical propagation phenomena have a great interest in academic research due to their ability to shed light on some complex quantum effects, which are impossible to visualize directly in the macroscopic world. In this talk, we describe a number of these analogies concerning the acoustic behavior of bubble clouds. Firstly, we show that the structure of the collective oscillation modes of a spherical bubble cloud resembles that of the atomic orbitals of a hydrogen atom. Secondly, we present an analogy between some perturbation methods used in quantum-electrodynamics and the computation of the acoustic response of the randomly distributed bubble cloud by considering the contribution to the total scattered pressure of the multiple scattering paths that take place inside the clouds. As an application of this analogy, we obtain the scattering cross-section of a diluted cloud, which remarkably mimics the quantum scattering of an neutron wave when passing through an atomic nucleus. Finally, we numerically reproduce the behavior of an electron in a covalent bond between two hydrogen atoms by simulating the acoustic wave propagation through two neighboring spherical bubble assemblages. Funded by the Spanish Ministry of Economy and Competitiveness through Grants DPI2011-28356-C03-01 and DPI2011-28356-C03-02.

Parallel Computing for Brain Simulation.

PubMed

Pastur-Romay, L A; Porto-Pazos, A B; Cedron, F; Pazos, A

2017-01-01

The human brain is the most complex system in the known universe, it is therefore one of the greatest mysteries. It provides human beings with extraordinary abilities. However, until now it has not been understood yet how and why most of these abilities are produced. For decades, researchers have been trying to make computers reproduce these abilities, focusing on both understanding the nervous system and, on processing data in a more efficient way than before. Their aim is to make computers process information similarly to the brain. Important technological developments and vast multidisciplinary projects have allowed creating the first simulation with a number of neurons similar to that of a human brain. This paper presents an up-to-date review about the main research projects that are trying to simulate and/or emulate the human brain. They employ different types of computational models using parallel computing: digital models, analog models and hybrid models. This review includes the current applications of these works, as well as future trends. It is focused on various works that look for advanced progress in Neuroscience and still others which seek new discoveries in Computer Science (neuromorphic hardware, machine learning techniques). Their most outstanding characteristics are summarized and the latest advances and future plans are presented. In addition, this review points out the importance of considering not only neurons: Computational models of the brain should also include glial cells, given the proven importance of astrocytes in information processing. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Computer simulation of preflight blood volume reduction as a countermeasure to fluid shifts in space flight

NASA Technical Reports Server (NTRS)

Simanonok, K. E.; Srinivasan, R.; Charles, J. B.

1992-01-01

Fluid shifts in weightlessness may cause a central volume expansion, activating reflexes to reduce the blood volume. Computer simulation was used to test the hypothesis that preadaptation of the blood volume prior to exposure to weightlessness could counteract the central volume expansion due to fluid shifts and thereby attenuate the circulatory and renal responses resulting in large losses of fluid from body water compartments. The Guyton Model of Fluid, Electrolyte, and Circulatory Regulation was modified to simulate the six degree head down tilt that is frequently use as an experimental analog of weightlessness in bedrest studies. Simulation results show that preadaptation of the blood volume by a procedure resembling a blood donation immediately before head down bedrest is beneficial in damping the physiologic responses to fluid shifts and reducing body fluid losses. After ten hours of head down tilt, blood volume after preadaptation is higher than control for 20 to 30 days of bedrest. Preadaptation also produces potentially beneficial higher extracellular volume and total body water for 20 to 30 days of bedrest.

Design and manufacture of customized dental implants by using reverse engineering and selective laser melting technology.

PubMed

Chen, Jianyu; Zhang, Zhiguang; Chen, Xianshuai; Zhang, Chunyu; Zhang, Gong; Xu, Zhewu

2014-11-01

Recently a new therapeutic concept of patient-specific implant dentistry has been advanced based on computer-aided design/computer-aided manufacturing technology. However, a comprehensive study of the design and 3-dimensional (3D) printing of the customized implants, their mechanical properties, and their biomechanical behavior is lacking. The purpose of this study was to evaluate the mechanical and biomechanical performance of a novel custom-made dental implant fabricated by the selective laser melting technique with simulation and in vitro experimental studies. Two types of customized implants were designed by using reverse engineering: a root-analog implant and a root-analog threaded implant. The titanium implants were printed layer by layer with the selective laser melting technique. The relative density, surface roughness, tensile properties, bend strength, and dimensional accuracy of the specimens were evaluated. Nonlinear and linear finite element analysis and experimental studies were used to investigate the stress distribution, micromotion, and primary stability of the implants. Selective laser melting 3D printing technology was able to reproduce the customized implant designs and produce high density and strength and adequate dimensional accuracy. Better stress distribution and lower maximum micromotions were observed for the root-analog threaded implant model than for the root-analog implant model. In the experimental tests, the implant stability quotient and pull-out strength of the 2 types of implants indicated that better primary stability can be obtained with a root-analog threaded implant design. Selective laser melting proved to be an efficient means of printing fully dense customized implants with high strength and sufficient dimensional accuracy. Adding the threaded characteristic to the customized root-analog threaded implant design maintained the approximate geometry of the natural root and exhibited better stress distribution and primary stability. Copyright © 2014 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

Direct Numerical Simulation of an Airfoil with Sand Grain Roughness on the Leading Edge

NASA Technical Reports Server (NTRS)

Ribeiro, Andre F. P.; Casalino, Damiano; Fares, Ehab; Choudhari, Meelan

2016-01-01

As part of a computational study of acoustic radiation due to the passage of turbulent boundary layer eddies over the trailing edge of an airfoil, the Lattice-Boltzmann method is used to perform direct numerical simulations of compressible, low Mach number flow past an NACA 0012 airfoil at zero degrees angle of attack. The chord Reynolds number of approximately 0.657 million models one of the test conditions from a previous experiment by Brooks, Pope, and Marcolini at NASA Langley Research Center. A unique feature of these simulations involves direct modeling of the sand grain roughness on the leading edge, which was used in the abovementioned experiment to trip the boundary layer to fully turbulent flow. This report documents the findings of preliminary, proof-of-concept simulations based on a narrow spanwise domain and a limited time interval. The inclusion of fully-resolved leading edge roughness in this simulation leads to significantly earlier transition than that in the absence of any roughness. The simulation data is used in conjunction with both the Ffowcs Williams-Hawkings acoustic analogy and a semi-analytical model by Roger and Moreau to predict the farfield noise. The encouraging agreement between the computed noise spectrum and that measured in the experiment indicates the potential payoff from a full-fledged numerical investigation based on the current approach. Analysis of the computed data is used to identify the required improvements to the preliminary simulations described herein.

Low order physical models of vertical axis wind turbines

NASA Astrophysics Data System (ADS)

Craig, Anna; Dabiri, John; Koseff, Jeffrey

2016-11-01

In order to examine the ability of low-order physical models of vertical axis wind turbines to accurately reproduce key flow characteristics, experiments were conducted on rotating turbine models, rotating solid cylinders, and stationary porous flat plates (of both uniform and non-uniform porosities). From examination of the patterns of mean flow, the wake turbulence spectra, and several quantitative metrics, it was concluded that the rotating cylinders represent a reasonably accurate analog for the rotating turbines. In contrast, from examination of the patterns of mean flow, it was found that the porous flat plates represent only a limited analog for rotating turbines (for the parameters examined). These findings have implications for both laboratory experiments and numerical simulations, which have previously used analogous low order models in order to reduce experimental/computational costs. NSF GRF and SGF to A.C; ONR N000141211047 and the Gordon and Betty Moore Foundation Grant GBMF2645 to J.D.; and the Bob and Norma Street Environmental Fluid Mechanics Laboratory at Stanford University.

Data and results of a laboratory investigation of microprocessor upset caused by simulated lightning-induced analog transients

NASA Technical Reports Server (NTRS)

Belcastro, C. M.

1984-01-01

A methodology was developed a assess the upset susceptibility/reliability of a computer system onboard an aircraft flying through a lightning environment. Upset error modes in a general purpose microprocessor were studied. The upset tests involved the random input of analog transients which model lightning induced signals onto interface lines of an 8080 based microcomputer from which upset error data was recorded. The program code on the microprocessor during tests is designed to exercise all of the machine cycles and memory addressing techniques implemented in the 8080 central processing unit. A statistical analysis is presented in which possible correlations are established between the probability of upset occurrence and transient signal inputs during specific processing states and operations. A stochastic upset susceptibility model for the 8080 microprocessor is presented. The susceptibility of this microprocessor to upset, once analog transients have entered the system, is determined analytically by calculating the state probabilities of the stochastic model.

Elevated temperature crack growth

NASA Technical Reports Server (NTRS)

Malik, S. N.; Vanstone, R. H.; Kim, K. S.; Laflen, J. H.

1985-01-01

The purpose is to determine the ability of currently available P-I integrals to correlate fatigue crack propagation under conditions that simulate the turbojet engine combustor liner environment. The utility of advanced fracture mechanics measurements will also be evaluated during the course of the program. To date, an appropriate specimen design, a crack displacement measurement method, and boundary condition simulation in the computational model of the specimen were achieved. Alloy 718 was selected as an analog material based on its ability to simulate high temperature behavior at lower temperatures. Tensile and cyclic tests were run at several strain rates so that an appropriate constitutive model could be developed. Suitable P-I integrals were programmed into a finite element post-processor for eventual comparison with experimental data.

Plasmonic computing of spatial differentiation

NASA Astrophysics Data System (ADS)

Zhu, Tengfeng; Zhou, Yihan; Lou, Yijie; Ye, Hui; Qiu, Min; Ruan, Zhichao; Fan, Shanhui

2017-05-01

Optical analog computing offers high-throughput low-power-consumption operation for specialized computational tasks. Traditionally, optical analog computing in the spatial domain uses a bulky system of lenses and filters. Recent developments in metamaterials enable the miniaturization of such computing elements down to a subwavelength scale. However, the required metamaterial consists of a complex array of meta-atoms, and direct demonstration of image processing is challenging. Here, we show that the interference effects associated with surface plasmon excitations at a single metal-dielectric interface can perform spatial differentiation. And we experimentally demonstrate edge detection of an image without any Fourier lens. This work points to a simple yet powerful mechanism for optical analog computing at the nanoscale.

Computer modeling of batteries from nonlinear circuit elements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waaben, S.; Dyer, C.K.; Federico, J.

1985-06-01

Circuit analogs for a single battery cell have previously been composed of resistors, capacitors, and inductors. This work introduces a nonlinear circuit model for cell behavior. The circuit is configured around the PIN junction diode, whose charge-storage behavior has features similar to those of electrochemical cells. A user-friendly integrated circuit simulation computer program has reproduced a variety of complex cell responses including electrica isolation effects causing capacity loss, as well as potentiodynamic peaks and discharge phenomena hitherto thought to be thermodynamic in origin. However, in this work, they are shown to be simply due to spatial distribution of stored chargemore » within a practical electrode.« less

Preliminary development of digital signal processing in microwave radiometers

NASA Technical Reports Server (NTRS)

Stanley, W. D.

1980-01-01

Topics covered involve a number of closely related tasks including: the development of several control loop and dynamic noise model computer programs for simulating microwave radiometer measurements; computer modeling of an existing stepped frequency radiometer in an effort to determine its optimum operational characteristics; investigation of the classical second order analog control loop to determine its ability to reduce the estimation error in a microwave radiometer; investigation of several digital signal processing unit designs; initiation of efforts to develop required hardware and software for implementation of the digital signal processing unit; and investigation of the general characteristics and peculiarities of digital processing noiselike microwave radiometer signals.

Kinetic theory of coupled oscillators.

PubMed

Hildebrand, Eric J; Buice, Michael A; Chow, Carson C

2007-02-02

We present an approach for the description of fluctuations that are due to finite system size induced correlations in the Kuramoto model of coupled oscillators. We construct a hierarchy for the moments of the density of oscillators that is analogous to the Bogoliubov-Born-Green-Kirkwood-Yvon hierarchy in the kinetic theory of plasmas and gases. To calculate the lowest order system size effect, we truncate this hierarchy at second order and solve the resulting closed equations for the two-oscillator correlation function around the incoherent state. We use this correlation function to compute the fluctuations of the order parameter, including the effect of transients, and compare this computation with numerical simulations.

A digital computer simulation and study of a direct-energy-transfer power-conditioning system

NASA Technical Reports Server (NTRS)

Burns, W. W., III; Owen, H. A., Jr.; Wilson, T. G.; Rodriguez, G. E.; Paulkovich, J.

1975-01-01

An investigation of the behavior of the power-conditioning system as a whole is a necessity to ensure the integrity of the aggregate system in the case of space applications. An approach for conducting such an investigation is considered. A description is given of the application of a general digital analog simulator program to the study of an aggregate power-conditioning system which is being developed for use on the International Ultraviolet Explorer spacecraft. The function of the direct energy transfer system studied involves a coupling of a solar array through a main distribution bus to the spacecraft electrical loads.

Analysis of turbojet-engine controls for afterburning starting

NASA Technical Reports Server (NTRS)

Phillips, W E , Jr

1956-01-01

A simulation procedure is developed for studying the effects of an afterburner start on a controlled turbojet engine. The afterburner start is represented by introducing a step decrease in the effective exhaust-nozzle area, after which the control returns the controlled engine variables to their initial values. The degree and speed with which the control acts are a measure of the effectiveness of the particular control system. Data are presented from five systems investigated using an electronic analog computer and the developed simulation procedure. These systems are compared with respect to steady-state errors, speed of response, and transient deviations of the system variables.

Bio-mimicked atomic-layer-deposited iron oxide-based memristor with synaptic potentiation and depression functions

NASA Astrophysics Data System (ADS)

Wan, Xiang; Gao, Fei; Lian, Xiaojuan; Ji, Xincun; Hu, Ertao; He, Lin; Tong, Yi; Guo, Yufeng

2018-06-01

In this study, an iron oxide (FeO x )-based memristor was investigated for the realization of artificial synapses. An FeO x resistive switching layer was prepared by self-limiting atomic layer deposition (ALD). The movement of oxygen vacancies enabled the device to have history-dependent synaptic functions, which was further demonstrated by device modeling and simulation. Analog synaptic potentiation/depression in conductance was emulated by applying consecutive voltage pulses in the simulation. Our results suggest that the ALD FeO x -based memristor can be used as the basic building block for neural networks, neuromorphic systems, and brain-inspired computers.

Versatile analog pulse height computer performs real-time arithmetic operations

NASA Technical Reports Server (NTRS)

Brenner, R.; Strauss, M. G.

1967-01-01

Multipurpose analog pulse height computer performs real-time arithmetic operations on relatively fast pulses. This computer can be used for identification of charged particles, pulse shape discrimination, division of signals from position sensitive detectors, and other on-line data reduction techniques.

Analog Computer Laboratory with Biological Examples.

ERIC Educational Resources Information Center

Strebel, Donald E.

1979-01-01

The use of biological examples in teaching applications of the analog computer is discussed and several examples from mathematical ecology, enzyme kinetics, and tracer dynamics are described. (Author/GA)

An Evaluation of Human Thermal Models for the Study of Immersion Hypothermia Protection Equipment

DTIC Science & Technology

1979-10-12

exhibited by the five experimental observations, largely due to somatotype differences among the subjects. None of the individual responses Is represented...not less than 35°C). A mathematical model capable of accurately simulating the thermal responses of a protected man in a cold environment would be an...flow) responses . The models are most generally expressed as a set of differential equa- tions. Early models were solved using analog computers. The

Optical properties of materials at low temperature and their application to optical detection

NASA Technical Reports Server (NTRS)

Hartwig, W. H.; Tarchi, A. A.

1972-01-01

A lumped model to represent the photodielectric effect is developed. An analog simulation for a sample in a microwave cavity with a static magnetic field is developed. A system to measure continuously the PDE is analyzed. A performance factor to compared PD detectors versus ac photoconductors is computed. The operating conditions are defined for the appropriate noise conditions. The detectivity of the detector is found to be limited by the semiconductor sample noise.

Speckle in the diffraction patterns of Hendricks-Teller and icosahedral glass models

NASA Technical Reports Server (NTRS)

Garg, Anupam; Levine, Dov

1988-01-01

It is shown that the X-ray diffraction patterns from the Hendricks-Teller model for layered systems and the icosahedral glass models for the icosahedral phases show large fluctuations between nearby scattering wave vectors and from sample to sample, that are quite analogous to laser speckle. The statistics of these fluctuations are studied analytically for the first model and via computer simulations for the second. The observability of these effects is discussed briefly.

Application of the aeroacoustic analogy to a shrouded, subsonic, radial fan

NASA Astrophysics Data System (ADS)

Buccieri, Bryan M.; Richards, Christopher M.

2016-12-01

A study was conducted to investigate the predictive capability of computational aeroacoustics with respect to a shrouded, subsonic, radial fan. A three dimensional unsteady fluid dynamics simulation was conducted to produce aerodynamic data used as the acoustic source for an aeroacoustics simulation. Two acoustic models were developed: one modeling the forces on the rotating fan blades as a set of rotating dipoles located at the center of mass of each fan blade and one modeling the forces on the stationary fan shroud as a field of distributed stationary dipoles. Predicted acoustic response was compared to experimental data measured at two operating speeds using three different outlet restrictions. The blade source model predicted overall far field sound power levels within 5 dB averaged over the six different operating conditions while the shroud model predicted overall far field sound power levels within 7 dB averaged over the same conditions. Doubling the density of the computational fluids mesh and using a scale adaptive simulation turbulence model increased broadband noise accuracy. However, computation time doubled and the accuracy of the overall sound power level prediction improved by only 1 dB.

Is scaffold hopping a reliable indicator for the ability of computational methods to identify structurally diverse active compounds?

NASA Astrophysics Data System (ADS)

Dimova, Dilyana; Bajorath, Jürgen

2017-07-01

Computational scaffold hopping aims to identify core structure replacements in active compounds. To evaluate scaffold hopping potential from a principal point of view, regardless of the computational methods that are applied, a global analysis of conventional scaffolds in analog series from compound activity classes was carried out. The majority of analog series was found to contain multiple scaffolds, thus enabling the detection of intra-series scaffold hops among closely related compounds. More than 1000 activity classes were found to contain increasing proportions of multi-scaffold analog series. Thus, using such activity classes for scaffold hopping analysis is likely to overestimate the scaffold hopping (core structure replacement) potential of computational methods, due to an abundance of artificial scaffold hops that are possible within analog series.

An improved data transfer and storage technique for hybrid computation

NASA Technical Reports Server (NTRS)

Hansing, A. M.

1972-01-01

Improved technique was developed for transferring and storing data at faster than real time speeds on hybrid computer. Predominant advantage is combined use of electronic relays, track and store units, and analog-to-digital and digital-to-analog conversion units of hybrid computer.

Life sciences Spacelab Mission Development test 3 (SMD 3) data management report

NASA Technical Reports Server (NTRS)

Moseley, E. C.

1977-01-01

Development of a permanent data system for SMD tests was studied that would simulate all elements of the shuttle onboard, telemetry, and ground data systems that are involved with spacelab operations. The onboard data system (ODS) and the ground data system (GDS) were utilized. The air-to-ground link was simulated by a hardwired computer-to-computer interface. A patch board system was used on board to select experiment inputs, and the downlink configuration from the ODS was changed by a crew keyboard entry to support each experiment. The ODS provided a CRT display of experiment parameters to enable the crew to monitor experiment performance. An onboard analog system, with recording capability, was installed to handle high rate data and to provide a backup to the digital system. The GDS accomplished engineering unit conversion and limit sensing, and provided realtime parameter display on CRT's in the science monitoring area and the test control area.

Improved Force Fields for Peptide Nucleic Acids with Optimized Backbone Torsion Parameters.

PubMed

Jasiński, Maciej; Feig, Michael; Trylska, Joanna

2018-06-06

Peptide nucleic acids are promising nucleic acid analogs for antisense therapies as they can form stable duplex and triplex structures with DNA and RNA. Computational studies of PNA-containing duplexes and triplexes are an important component for guiding their design, yet existing force fields have not been well validated and parametrized with modern computational capabilities. We present updated CHARMM and Amber force fields for PNA that greatly improve the stability of simulated PNA-containing duplexes and triplexes in comparison with experimental structures and allow such systems to be studied on microsecond time scales. The force field modifications focus on reparametrized PNA backbone torsion angles to match high-level quantum mechanics reference energies for a model compound. The microsecond simulations of PNA-PNA, PNA-DNA, PNA-RNA, and PNA-DNA-PNA complexes also allowed a comprehensive analysis of hydration and ion interactions with such systems.

Design of the liquefied natural gas (LNG) vehicle gas cylinder filling semi-physical simulation training and assessment system

NASA Astrophysics Data System (ADS)

Gao, Jie; Zheng, Jianrong; Zhao, Yinghui

2017-08-01

With the rapid development of LNG vehicle in China, the operator's training and assessment of the operating skills cannot operate on material objects, because of Vehicle Gas Cylinder's high pressure, flammable and explosive characteristics. LNG Vehicle Gas Cylinder's filling simulation system with semi-physical simulation technology presents the overall design and procedures of the simulation system, and elaborates the realization of the practical analog machine, data acquisition and control system and the computer software, and introduces the design process of equipment simulation model in detail. According to the designed assessment system of the Vehicle Gas Cylinder, it can obtain the operation on the actual cylinder filling and visual effects for the operator, and automatically record operation, the results of real operation with its software, and achieve the operators' training and assessment of operating skills on mobile special equipment.

Quantum Analog Computing

NASA Technical Reports Server (NTRS)

Zak, M.

1998-01-01

Quantum analog computing is based upon similarity between mathematical formalism of quantum mechanics and phenomena to be computed. It exploits a dynamical convergence of several competing phenomena to an attractor which can represent an externum of a function, an image, a solution to a system of ODE, or a stochastic process.

DockoMatic: automated peptide analog creation for high throughput virtual screening.

PubMed

Jacob, Reed B; Bullock, Casey W; Andersen, Tim; McDougal, Owen M

2011-10-01

The purpose of this manuscript is threefold: (1) to describe an update to DockoMatic that allows the user to generate cyclic peptide analog structure files based on protein database (pdb) files, (2) to test the accuracy of the peptide analog structure generation utility, and (3) to evaluate the high throughput capacity of DockoMatic. The DockoMatic graphical user interface interfaces with the software program Treepack to create user defined peptide analogs. To validate this approach, DockoMatic produced cyclic peptide analogs were tested for three-dimensional structure consistency and binding affinity against four experimentally determined peptide structure files available in the Research Collaboratory for Structural Bioinformatics database. The peptides used to evaluate this new functionality were alpha-conotoxins ImI, PnIA, and their published analogs. Peptide analogs were generated by DockoMatic and tested for their ability to bind to X-ray crystal structure models of the acetylcholine binding protein originating from Aplysia californica. The results, consisting of more than 300 simulations, demonstrate that DockoMatic predicts the binding energy of peptide structures to within 3.5 kcal mol(-1), and the orientation of bound ligand compares to within 1.8 Å root mean square deviation for ligand structures as compared to experimental data. Evaluation of high throughput virtual screening capacity demonstrated that Dockomatic can collect, evaluate, and summarize the output of 10,000 AutoDock jobs in less than 2 hours of computational time, while 100,000 jobs requires approximately 15 hours and 1,000,000 jobs is estimated to take up to a week. Copyright © 2011 Wiley Periodicals, Inc.

Optoelectronic analogs of self-programming neural nets - Architecture and methodologies for implementing fast stochastic learning by simulated annealing

NASA Technical Reports Server (NTRS)

Farhat, Nabil H.

1987-01-01

Self-organization and learning is a distinctive feature of neural nets and processors that sets them apart from conventional approaches to signal processing. It leads to self-programmability which alleviates the problem of programming complexity in artificial neural nets. In this paper architectures for partitioning an optoelectronic analog of a neural net into distinct layers with prescribed interconnectivity pattern to enable stochastic learning by simulated annealing in the context of a Boltzmann machine are presented. Stochastic learning is of interest because of its relevance to the role of noise in biological neural nets. Practical considerations and methodologies for appreciably accelerating stochastic learning in such a multilayered net are described. These include the use of parallel optical computing of the global energy of the net, the use of fast nonvolatile programmable spatial light modulators to realize fast plasticity, optical generation of random number arrays, and an adaptive noisy thresholding scheme that also makes stochastic learning more biologically plausible. The findings reported predict optoelectronic chips that can be used in the realization of optical learning machines.

Study of the Effects of Photometric Geometry on Spectral Reflectance Measurements

NASA Technical Reports Server (NTRS)

Helfenstein, Paul

1998-01-01

The objective of this research is to investigate how the spectrophotometric properties of planetary surface materials depend on photometric geometry by refining and applying radiative transfer theory to data obtained from spacecraft and telescope observations of planetary surfaces, studies of laboratory analogs, and computer simulations. The goal is to perfect the physical interpretation of photometric parameters in the context of planetary surface geological properties and processes. The purpose of this report is to document the research achievements associated with this study.

Solving constant-coefficient differential equations with dielectric metamaterials

NASA Astrophysics Data System (ADS)

Zhang, Weixuan; Qu, Che; Zhang, Xiangdong

2016-07-01

Recently, the concept of metamaterial analog computing has been proposed (Silva et al 2014 Science 343 160-3). Some mathematical operations such as spatial differentiation, integration, and convolution, have been performed by using designed metamaterial blocks. Motivated by this work, we propose a practical approach based on dielectric metamaterial to solve differential equations. The ordinary differential equation can be solved accurately by the correctly designed metamaterial system. The numerical simulations using well-established numerical routines have been performed to successfully verify all theoretical analyses.

Decentralized real-time simulation of forest machines

NASA Astrophysics Data System (ADS)

Freund, Eckhard; Adam, Frank; Hoffmann, Katharina; Rossmann, Juergen; Kraemer, Michael; Schluse, Michael

2000-10-01

To develop realistic forest machine simulators is a demanding task. A useful simulator has to provide a close- to-reality simulation of the forest environment as well as the simulation of the physics of the vehicle. Customers demand a highly realistic three dimensional forestry landscape and the realistic simulation of the complex motion of the vehicle even in rough terrain in order to be able to use the simulator for operator training under close-to- reality conditions. The realistic simulation of the vehicle, especially with the driver's seat mounted on a motion platform, greatly improves the effect of immersion into the virtual reality of a simulated forest and the achievable level of education of the driver. Thus, the connection of the real control devices of forest machines to the simulation system has to be supported, i.e. the real control devices like the joysticks or the board computer system to control the crane, the aggregate etc. Beyond, the fusion of the board computer system and the simulation system is realized by means of sensors, i.e. digital and analog signals. The decentralized system structure allows several virtual reality systems to evaluate and visualize the information of the control devices and the sensors. So, while the driver is practicing, the instructor can immerse into the same virtual forest to monitor the session from his own viewpoint. In this paper, we are describing the realized structure as well as the necessary software and hardware components and application experiences.

The Analog (Computer) As a Physiology Adjunct.

ERIC Educational Resources Information Center

Stewart, Peter A.

1979-01-01

Defines and discusses the analog computer and its use in a physiology laboratory. Includes two examples: (1) The Respiratory Control Function and (2) CO-Two Control in the Respiratory System. Presents diagrams and mathematical models. (MA)

Matrix-vector multiplication using digital partitioning for more accurate optical computing

NASA Technical Reports Server (NTRS)

Gary, C. K.

1992-01-01

Digital partitioning offers a flexible means of increasing the accuracy of an optical matrix-vector processor. This algorithm can be implemented with the same architecture required for a purely analog processor, which gives optical matrix-vector processors the ability to perform high-accuracy calculations at speeds comparable with or greater than electronic computers as well as the ability to perform analog operations at a much greater speed. Digital partitioning is compared with digital multiplication by analog convolution, residue number systems, and redundant number representation in terms of the size and the speed required for an equivalent throughput as well as in terms of the hardware requirements. Digital partitioning and digital multiplication by analog convolution are found to be the most efficient alogrithms if coding time and hardware are considered, and the architecture for digital partitioning permits the use of analog computations to provide the greatest throughput for a single processor.

Users manual for flight control design programs

NASA Technical Reports Server (NTRS)

Nalbandian, J. Y.

1975-01-01

Computer programs for the design of analog and digital flight control systems are documented. The program DIGADAPT uses linear-quadratic-gaussian synthesis algorithms in the design of command response controllers and state estimators, and it applies covariance propagation analysis to the selection of sampling intervals for digital systems. Program SCHED executes correlation and regression analyses for the development of gain and trim schedules to be used in open-loop explicit-adaptive control laws. A linear-time-varying simulation of aircraft motions is provided by the program TVHIS, which includes guidance and control logic, as well as models for control actuator dynamics. The programs are coded in FORTRAN and are compiled and executed on both IBM and CDC computers.

Compaction Behavior of Granular Materials

NASA Astrophysics Data System (ADS)

Endicott, Mark R.; Kenkre, V. M.; Glass, S. Jill; Hurd, Alan J.

1996-03-01

We report the results of our recent study of compaction of granular materials. A theoretical model is developed for the description of the compaction of granular materials exemplified by granulated ceramic powders. Its predictions are compared to observations of uniaxial compaction tests of ceramic granules of PMN-PT, spray dried alumina and rutile. The theoretical model employs a volume-based statistical mechanics treatment and an activation analogy. Results of a computer simulation of random packing of discs in two dimensions are also reported. The effect of type of particle size distribution and other parameters of that distribution on the calculated quantities are discussed. We examine the implications of the results of the simulation for the theoretical model.

Real time flight simulation methodology

NASA Technical Reports Server (NTRS)

Parrish, E. A.; Cook, G.; Mcvey, E. S.

1976-01-01

An example sensitivity study is presented to demonstrate how a digital autopilot designer could make a decision on minimum sampling rate for computer specification. It consists of comparing the simulated step response of an existing analog autopilot and its associated aircraft dynamics to the digital version operating at various sampling frequencies and specifying a sampling frequency that results in an acceptable change in relative stability. In general, the zero order hold introduces phase lag which will increase overshoot and settling time. It should be noted that this solution is for substituting a digital autopilot for a continuous autopilot. A complete redesign could result in results which more closely resemble the continuous results or which conform better to original design goals.

Bifurcation-based adiabatic quantum computation with a nonlinear oscillator network

PubMed Central

Goto, Hayato

2016-01-01

The dynamics of nonlinear systems qualitatively change depending on their parameters, which is called bifurcation. A quantum-mechanical nonlinear oscillator can yield a quantum superposition of two oscillation states, known as a Schrödinger cat state, via quantum adiabatic evolution through its bifurcation point. Here we propose a quantum computer comprising such quantum nonlinear oscillators, instead of quantum bits, to solve hard combinatorial optimization problems. The nonlinear oscillator network finds optimal solutions via quantum adiabatic evolution, where nonlinear terms are increased slowly, in contrast to conventional adiabatic quantum computation or quantum annealing, where quantum fluctuation terms are decreased slowly. As a result of numerical simulations, it is concluded that quantum superposition and quantum fluctuation work effectively to find optimal solutions. It is also notable that the present computer is analogous to neural computers, which are also networks of nonlinear components. Thus, the present scheme will open new possibilities for quantum computation, nonlinear science, and artificial intelligence. PMID:26899997

Sub-grid drag models for horizontal cylinder arrays immersed in gas-particle multiphase flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarkar, Avik; Sun, Xin; Sundaresan, Sankaran

2013-09-08

Immersed cylindrical tube arrays often are used as heat exchangers in gas-particle fluidized beds. In multiphase computational fluid dynamics (CFD) simulations of large fluidized beds, explicit resolution of small cylinders is computationally infeasible. Instead, the cylinder array may be viewed as an effective porous medium in coarse-grid simulations. The cylinders' influence on the suspension as a whole, manifested as an effective drag force, and on the relative motion between gas and particles, manifested as a correction to the gas-particle drag, must be modeled via suitable sub-grid constitutive relationships. In this work, highly resolved unit-cell simulations of flow around an arraymore » of horizontal cylinders, arranged in a staggered configuration, are filtered to construct sub-grid, or `filtered', drag models, which can be implemented in coarse-grid simulations. The force on the suspension exerted by the cylinders is comprised of, as expected, a buoyancy contribution, and a kinetic component analogous to fluid drag on a single cylinder. Furthermore, the introduction of tubes also is found to enhance segregation at the scale of the cylinder size, which, in turn, leads to a reduction in the filtered gas-particle drag.« less

Comparison of Monte Carlo simulated and measured performance parameters of miniPET scanner

NASA Astrophysics Data System (ADS)

Kis, S. A.; Emri, M.; Opposits, G.; Bükki, T.; Valastyán, I.; Hegyesi, Gy.; Imrek, J.; Kalinka, G.; Molnár, J.; Novák, D.; Végh, J.; Kerek, A.; Trón, L.; Balkay, L.

2007-02-01

In vivo imaging of small laboratory animals is a valuable tool in the development of new drugs. For this purpose, miniPET, an easy to scale modular small animal PET camera has been developed at our institutes. The system has four modules, which makes it possible to rotate the whole detector system around the axis of the field of view. Data collection and image reconstruction are performed using a data acquisition (DAQ) module with Ethernet communication facility and a computer cluster of commercial PCs. Performance tests were carried out to determine system parameters, such as energy resolution, sensitivity and noise equivalent count rate. A modified GEANT4-based GATE Monte Carlo software package was used to simulate PET data analogous to those of the performance measurements. GATE was run on a Linux cluster of 10 processors (64 bit, Xeon with 3.0 GHz) and controlled by a SUN grid engine. The application of this special computer cluster reduced the time necessary for the simulations by an order of magnitude. The simulated energy spectra, maximum rate of true coincidences and sensitivity of the camera were in good agreement with the measured parameters.

Digital-analog quantum simulation of generalized Dicke models with superconducting circuits

NASA Astrophysics Data System (ADS)

Lamata, Lucas

We propose a digital-analog quantum simulation of generalized Dicke models with superconducting circuits, including Fermi-Bose condensates, biased and pulsed Dicke models, for all regimes of light-matter coupling. We encode these classes of problems in a set of superconducting qubits coupled with a bosonic mode implemented by a transmission line resonator. Via digital-analog techniques, an efficient quantum simulation can be performed in state-of-the-art circuit quantum electrodynamics platforms, by suitable decomposition into analog qubit-bosonic blocks and collective single-qubit pulses through digital steps. Moreover, just a single global analog block would be needed during the whole protocol in most of the cases, superimposed with fast periodic pulses to rotate and detune the qubits. Therefore, a large number of digital steps may be attained with this approach, providing a reduced digital error. Additionally, the number of gates per digital step does not grow with the number of qubits, rendering the simulation efficient. This strategy paves the way for the scalable digital-analog quantum simulation of many-body dynamics involving bosonic modes and spin degrees of freedom with superconducting circuits. The author wishes to acknowledge discussions with I. Arrazola, A. Mezzacapo, J. S. Pedernales, and E. Solano, and support from Ramon y Cajal Grant RYC-2012-11391, Spanish MINECO/FEDER FIS2015-69983-P, UPV/EHU UFI 11/55 and Project EHUA14/04.

Towards pattern generation and chaotic series prediction with photonic reservoir computers

NASA Astrophysics Data System (ADS)

Antonik, Piotr; Hermans, Michiel; Duport, François; Haelterman, Marc; Massar, Serge

2016-03-01

Reservoir Computing is a bio-inspired computing paradigm for processing time dependent signals that is particularly well suited for analog implementations. Our team has demonstrated several photonic reservoir computers with performance comparable to digital algorithms on a series of benchmark tasks such as channel equalisation and speech recognition. Recently, we showed that our opto-electronic reservoir computer could be trained online with a simple gradient descent algorithm programmed on an FPGA chip. This setup makes it in principle possible to feed the output signal back into the reservoir, and thus highly enrich the dynamics of the system. This will allow to tackle complex prediction tasks in hardware, such as pattern generation and chaotic and financial series prediction, which have so far only been studied in digital implementations. Here we report simulation results of our opto-electronic setup with an FPGA chip and output feedback applied to pattern generation and Mackey-Glass chaotic series prediction. The simulations take into account the major aspects of our experimental setup. We find that pattern generation can be easily implemented on the current setup with very good results. The Mackey-Glass series prediction task is more complex and requires a large reservoir and more elaborate training algorithm. With these adjustments promising result are obtained, and we now know what improvements are needed to match previously reported numerical results. These simulation results will serve as basis of comparison for experiments we will carry out in the coming months.

Ant system: optimization by a colony of cooperating agents.

PubMed

Dorigo, M; Maniezzo, V; Colorni, A

1996-01-01

An analogy with the way ant colonies function has suggested the definition of a new computational paradigm, which we call ant system (AS). We propose it as a viable new approach to stochastic combinatorial optimization. The main characteristics of this model are positive feedback, distributed computation, and the use of a constructive greedy heuristic. Positive feedback accounts for rapid discovery of good solutions, distributed computation avoids premature convergence, and the greedy heuristic helps find acceptable solutions in the early stages of the search process. We apply the proposed methodology to the classical traveling salesman problem (TSP), and report simulation results. We also discuss parameter selection and the early setups of the model, and compare it with tabu search and simulated annealing using TSP. To demonstrate the robustness of the approach, we show how the ant system (AS) can be applied to other optimization problems like the asymmetric traveling salesman, the quadratic assignment and the job-shop scheduling. Finally we discuss the salient characteristics-global data structure revision, distributed communication and probabilistic transitions of the AS.

Trapped-Ion Quantum Logic with Global Radiation Fields.

PubMed

Weidt, S; Randall, J; Webster, S C; Lake, K; Webb, A E; Cohen, I; Navickas, T; Lekitsch, B; Retzker, A; Hensinger, W K

2016-11-25

Trapped ions are a promising tool for building a large-scale quantum computer. However, the number of required radiation fields for the realization of quantum gates in any proposed ion-based architecture scales with the number of ions within the quantum computer, posing a major obstacle when imagining a device with millions of ions. Here, we present a fundamentally different approach for trapped-ion quantum computing where this detrimental scaling vanishes. The method is based on individually controlled voltages applied to each logic gate location to facilitate the actual gate operation analogous to a traditional transistor architecture within a classical computer processor. To demonstrate the key principle of this approach we implement a versatile quantum gate method based on long-wavelength radiation and use this method to generate a maximally entangled state of two quantum engineered clock qubits with fidelity 0.985(12). This quantum gate also constitutes a simple-to-implement tool for quantum metrology, sensing, and simulation.

A computational investigation of the finite-time blow-up of the 3D incompressible Euler equations based on the Voigt regularization

DOE PAGES

Larios, Adam; Petersen, Mark R.; Titi, Edriss S.; ...

2017-04-29

We report the results of a computational investigation of two blow-up criteria for the 3D incompressible Euler equations. One criterion was proven in a previous work, and a related criterion is proved here. These criteria are based on an inviscid regularization of the Euler equations known as the 3D Euler-Voigt equations, which are known to be globally well-posed. Moreover, simulations of the 3D Euler-Voigt equations also require less resolution than simulations of the 3D Euler equations for xed values of the regularization parameter α > 0. Therefore, the new blow-up criteria allow one to gain information about possible singularity formationmore » in the 3D Euler equations indirectly; namely, by simulating the better-behaved 3D Euler-Voigt equations. The new criteria are only known to be suficient for blow-up. Therefore, to test the robustness of the inviscid-regularization approach, we also investigate analogous criteria for blow-up of the 1D Burgers equation, where blow-up is well-known to occur.« less

A computational investigation of the finite-time blow-up of the 3D incompressible Euler equations based on the Voigt regularization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larios, Adam; Petersen, Mark R.; Titi, Edriss S.

We report the results of a computational investigation of two blow-up criteria for the 3D incompressible Euler equations. One criterion was proven in a previous work, and a related criterion is proved here. These criteria are based on an inviscid regularization of the Euler equations known as the 3D Euler-Voigt equations, which are known to be globally well-posed. Moreover, simulations of the 3D Euler-Voigt equations also require less resolution than simulations of the 3D Euler equations for xed values of the regularization parameter α > 0. Therefore, the new blow-up criteria allow one to gain information about possible singularity formationmore » in the 3D Euler equations indirectly; namely, by simulating the better-behaved 3D Euler-Voigt equations. The new criteria are only known to be suficient for blow-up. Therefore, to test the robustness of the inviscid-regularization approach, we also investigate analogous criteria for blow-up of the 1D Burgers equation, where blow-up is well-known to occur.« less

Xyce™ Parallel Electronic Simulator Users' Guide, Version 6.5.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keiter, Eric R.; Aadithya, Karthik V.; Mei, Ting

This manual describes the use of the Xyce Parallel Electronic Simulator. Xyce has been designed as a SPICE-compatible, high-performance analog circuit simulator, and has been written to support the simulation needs of the Sandia National Laboratories electrical designers. This development has focused on improving capability over the current state-of-the-art in the following areas: Capability to solve extremely large circuit problems by supporting large-scale parallel computing platforms (up to thousands of processors). This includes support for most popular parallel and serial computers. A differential-algebraic-equation (DAE) formulation, which better isolates the device model package from solver algorithms. This allows one to developmore » new types of analysis without requiring the implementation of analysis-specific device models. Device models that are specifically tailored to meet Sandia's needs, including some radiation- aware devices (for Sandia users only). Object-oriented code design and implementation using modern coding practices. Xyce is a parallel code in the most general sense of the phrase -- a message passing parallel implementation -- which allows it to run efficiently a wide range of computing platforms. These include serial, shared-memory and distributed-memory parallel platforms. Attention has been paid to the specific nature of circuit-simulation problems to ensure that optimal parallel efficiency is achieved as the number of processors grows. The information herein is subject to change without notice. Copyright © 2002-2016 Sandia Corporation. All rights reserved.« less

Fast simulation of yttrium-90 bremsstrahlung photons with GATE.

PubMed

Rault, Erwann; Staelens, Steven; Van Holen, Roel; De Beenhouwer, Jan; Vandenberghe, Stefaan

2010-06-01

Multiple investigators have recently reported the use of yttrium-90 (90Y) bremsstrahlung single photon emission computed tomography (SPECT) imaging for the dosimetry of targeted radionuclide therapies. Because Monte Carlo (MC) simulations are useful for studying SPECT imaging, this study investigates the MC simulation of 90Y bremsstrahlung photons in SPECT. To overcome the computationally expensive simulation of electrons, the authors propose a fast way to simulate the emission of 90Y bremsstrahlung photons based on prerecorded bremsstrahlung photon probability density functions (PDFs). The accuracy of bremsstrahlung photon simulation is evaluated in two steps. First, the validity of the fast bremsstrahlung photon generator is checked. To that end, fast and analog simulations of photons emitted from a 90Y point source in a water phantom are compared. The same setup is then used to verify the accuracy of the bremsstrahlung photon simulations, comparing the results obtained with PDFs generated from both simulated and measured data to measurements. In both cases, the energy spectra and point spread functions of the photons detected in a scintillation camera are used. Results show that the fast simulation method is responsible for a 5% overestimation of the low-energy fluence (below 75 keV) of the bremsstrahlung photons detected using a scintillation camera. The spatial distribution of the detected photons is, however, accurately reproduced with the fast method and a computational acceleration of approximately 17-fold is achieved. When measured PDFs are used in the simulations, the simulated energy spectrum of photons emitted from a point source of 90Y in a water phantom and detected in a scintillation camera closely approximates the measured spectrum. The PSF of the photons imaged in the 50-300 keV energy window is also accurately estimated with a 12.4% underestimation of the full width at half maximum and 4.5% underestimation of the full width at tenth maximum. Despite its limited accuracy, the fast bremsstrahlung photon generator is well suited for the simulation of bremsstrahlung photons emitted in large homogeneous organs, such as the liver, and detected in a scintillation camera. The computational acceleration makes it very useful for future investigations of 90Y bremsstrahlung SPECT imaging.

In silico designing of hyper-glycosylated analogs for the human coagulation factor IX.

PubMed

Ghasemi, Fahimeh; Zomorodipour, Alireza; Karkhane, Ali Asghar; Khorramizadeh, M Reza

2016-07-01

N-glycosylation is a process during which a glycan moiety attaches to the asparagine residue in the N-glycosylation consensus sequence (Asn-Xxx-Ser/Thr), where Xxx can be any amino acid except proline. Introduction of a new N-glycosylation site into a protein backbone leads to its hyper-glycosylation, and may improve the protein properties such as solubility, folding, stability, and secretion. Glyco-engineering is an approach to facilitate the hyper-glycosylation of recombinant proteins by application of the site-directed mutagenesis methods. In this regard, selection of a suitable location on the surface of a protein for introduction of a new N-glycosylation site is a main concern. In this work, a computational approach was conducted to select suitable location(s) for introducing new N-glycosylation sites into the human coagulation factor IX (hFIX). With this aim, the first 45 residues of mature hFIX were explored to find out suitable positions for introducing either Asn or Ser/Thr residues, to create new N-glycosylation site(s). Our exploration lead to detection of five potential positions, for hyper-glycosylation. For each suggested position, an analog was defined and subjected for N-glycosylation efficiency prediction. After generation of three-dimensional structures, by homology-based modeling, the five designed analogs were examined by molecular dynamic (MD) simulations, to predict their stability levels and probable structural distortions caused by amino acid substitutions, relative to the native counterpart. Three out of five suggested analogs, namely; E15T, K22N, and R37N, reached equilibration state with relatively constant Root Mean Square Deviation values. Additional analysis on the data obtained during MD simulations, lead us to conclude that, R37N is the only qualified analog with the most similar structure and dynamic behavior to that of the native counterpart, to be considered for further experimental investigations. Copyright © 2016 Elsevier Inc. All rights reserved.

TVC actuator model. [for the space shuttle main engine

NASA Technical Reports Server (NTRS)

Baslock, R. W.

1977-01-01

A prototype Space Shuttle Main Engine (SSME) Thrust Vector Control (TVC) Actuator analog model was successfully completed. The prototype, mounted on five printed circuit (PC) boards, was delivered to NASA, checked out and tested using a modular replacement technique on an analog computer. In all cases, the prototype model performed within the recording techniques of the analog computer which is well within the tolerances of the specifications.

Simulations of the Viking Gas Exchange Experiment using palagonite and Fe-rich montmorillonite as terrestrial analogs: implications for the surface composition of Mars.

PubMed

Quinn, R; Orenberg, J

1993-10-01

Simulations of the Gas Exchange Experiment (GEX), one of the Viking Lander Biology Experiments, were run using palagonite and Fe-rich montmorillonite as terrestrial analogs of the Martian soil. These terrestrial analogs were exposed to a nutrient solution of the same composition as that of the Viking Landers under humid (no contact with nutrient) and wet (intimate contact) conditions. The headspace gases in the GEX sample cell were sampled and then analyzed by gas chromatography under both humid and wet conditions. Five gases were monitored: CO2, N2, O2, Ar, and Kr. It was determined that in order to simulate the CO2 gas changes of the Viking GEX experiment, the mixture of soil analog mineral plus nutrient medium must be slightly (pH = 7.4) to moderately basic (pH = 8.7). This conclusion suggests constraints upon the composition of terrestrial analogs to the Mars soil; acidic components may be present, but the overall mixture must be basic in order to simulate the Viking GEX results.

Simulations of the Viking gas exchange experiment using palagonite and Fe-rich montmorillonite as terrestrial analogs - Implications for the surface composition of Mars

NASA Astrophysics Data System (ADS)

Quinn, Richard; Orenberg, James

1993-10-01

Simulations of the Gas Exchange Experiment (GEX), one of the Viking Lander Biology Experiments, were run using palagonite and Fe-rich montmorillonite as terrestrial analogs of the Martian soil. These terrestrial analogs were exposed to a nutrient solution of the same composition as that of the Viking Landers under humid (no contact with nutrient) and wet (intimate contact) conditions. The headspace gases in the GEX sample cell were sampled and then analyzed by gas chromatography under both humid and wet conditions. Five gases were monitored: CO2, N2, O2, Ar, and Kr. It was determined that in order to simulate the CO2 gas changes of the Viking GEX experiment, the mixture of soil analog mineral plus nutrient medium must be slightly (pH = 7.4) to moderately basic (pH = 8.7). This conclusion suggests constraints upon the composition of terrestrial analogs of the Mars soil; acidic components may be present, but the overall mixture must be basic in order to simulate the Viking GEX results.

Optical Eigenvector.

DTIC Science & Technology

1984-10-01

it necessary and identify by blckci -. mbrr, ’At tile bneginninp, of this contract , bot], -,-j- .lc the rest of the optical community imagined * that...simple analog optical computer,, could produce satisfactory solutions to elgenproblems. Earl’ - in this contract we improved optical computing... contract both we and the rest of the optical community imagined that simple analog optical computers could produce . satisfactory solutions to

Great Computational Intelligence in the Formal Sciences via Analogical Reasoning

DTIC Science & Technology

2017-05-08

computational harnessing of traditional mathematical statistics (as e.g. covered in Hogg, Craig & McKean 2005) is used to power statistical learning techniques...AFRL-AFOSR-VA-TR-2017-0099 Great Computational Intelligence in the Formal Sciences via Analogical Reasoning Selmer Bringsjord RENSSELAER POLYTECHNIC...08-05-2017 2. REPORT TYPE Final Performance 3. DATES COVERED (From - To) 15 Oct 2011 to 31 Dec 2016 4. TITLE AND SUBTITLE Great Computational

Remineralization of artificial dentinal caries lesions by biomimetically modified Mineral Trioxide Aggregate

PubMed Central

Qi, Yi-pin; Li, Nan; Niu, Li-na; Primus, Carolyn M.; Ling, Jun-Qi; Pashley, David H.; Tay, Franklin R.

2011-01-01

Fluoride-releasing restorative materials are available for remineralization of enamel and root caries. However, dentin remineralization is more difficult than enamel remineralization due to the paucity of apatite seed crystallites along the lesion surface for heterogeneous crystal growth. Extracellular matrix proteins play critical roles in controlling apatite nucleation/growth in collagenous tissues. This study examined the remineralization efficacy of mineral trioxide aggregate (MTA) in phosphate-containing simulated body fluid (SBF) by incorporating polyacrylic acid and sodium tripolyphosphate as biomimetic analogs of matrix proteins for remineralizing caries-like dentin. Artificial caries-like dentin lesions incubated in SBF were remineralized over a 6-week period using MTA or MTA containing biomimetic analogs in the absence or presence of dentin adhesive application. Lesion depths and integrated mineral loss were monitored with micro-computed tomography. Ultrastructure of baseline and remineralized lesions were examined by transmission electron microscopy. Dentin remineralization was best achieved using MTA containing biomimetic analogs regardless of whether an adhesive was applied; dentinal tubules within the remineralized dentin were occluded by apatite. It is concluded that the MTA version employed in the study may be doped with biomimetic analogs for remineralization of unbonded and bonded artificial caries-like lesions in the presence of SBF. PMID:22085925

Docking Simulation of the Binding Interactions of Saxitoxin Analogs Produced by the Marine Dinoflagellate Gymnodinium catenatum to the Voltage-Gated Sodium Channel Nav1.4.

PubMed

Durán-Riveroll, Lorena M; Cembella, Allan D; Band-Schmidt, Christine J; Bustillos-Guzmán, José J; Correa-Basurto, José

2016-05-06

Saxitoxin (STX) and its analogs are paralytic alkaloid neurotoxins that block the voltage-gated sodium channel pore (Nav), impeding passage of Na⁺ ions into the intracellular space, and thereby preventing the action potential in the peripheral nervous system and skeletal muscle. The marine dinoflagellate Gymnodinium catenatum produces an array of such toxins, including the recently discovered benzoyl analogs, for which the mammalian toxicities are essentially unknown. We subjected STX and its analogs to a theoretical docking simulation based upon two alternative tri-dimensional models of the Nav1.4 to find a relationship between the binding properties and the known mammalian toxicity of selected STX analogs. We inferred hypothetical toxicities for the benzoyl analogs from the modeled values. We demonstrate that these toxins exhibit different binding modes with similar free binding energies and that these alternative binding modes are equally probable. We propose that the principal binding that governs ligand recognition is mediated by electrostatic interactions. Our simulation constitutes the first in silico modeling study on benzoyl-type paralytic toxins and provides an approach towards a better understanding of the mode of action of STX and its analogs.

Docking Simulation of the Binding Interactions of Saxitoxin Analogs Produced by the Marine Dinoflagellate Gymnodinium catenatum to the Voltage-Gated Sodium Channel Nav1.4

PubMed Central

Durán-Riveroll, Lorena M.; Cembella, Allan D.; Band-Schmidt, Christine J.; Bustillos-Guzmán, José J.; Correa-Basurto, José

2016-01-01

Saxitoxin (STX) and its analogs are paralytic alkaloid neurotoxins that block the voltage-gated sodium channel pore (Nav), impeding passage of Na+ ions into the intracellular space, and thereby preventing the action potential in the peripheral nervous system and skeletal muscle. The marine dinoflagellate Gymnodinium catenatum produces an array of such toxins, including the recently discovered benzoyl analogs, for which the mammalian toxicities are essentially unknown. We subjected STX and its analogs to a theoretical docking simulation based upon two alternative tri-dimensional models of the Nav1.4 to find a relationship between the binding properties and the known mammalian toxicity of selected STX analogs. We inferred hypothetical toxicities for the benzoyl analogs from the modeled values. We demonstrate that these toxins exhibit different binding modes with similar free binding energies and that these alternative binding modes are equally probable. We propose that the principal binding that governs ligand recognition is mediated by electrostatic interactions. Our simulation constitutes the first in silico modeling study on benzoyl-type paralytic toxins and provides an approach towards a better understanding of the mode of action of STX and its analogs. PMID:27164145

Conversion of cardiac performance data in analog form for digital computer entry

NASA Technical Reports Server (NTRS)

Miller, R. L.

1972-01-01

A system is presented which will reduce analog cardiac performance data and convert the results to digital form for direct entry into a commercial time-shared computer. Circuits are discussed which perform the measurement and digital conversion of instantaneous systolic and diastolic parameters from the analog blood pressure waveform. Digital averaging over a selected number of heart cycles is performed on these measurements, as well as those of flow and heart rate. The determination of average cardiac output and peripheral resistance, including trends, is the end result after processing by digital computer.

The Lenz Vector and Orbital Analog Computers

ERIC Educational Resources Information Center

Harter, W. G.

1976-01-01

Describes a single geometrical diagram based on the Lenz vector which shows the qualitative and quantitative features of all three types of Coulomb orbits. Explains the use of a simple analog computer with an overhead projector to demonstrate many of these effects. (Author/CP)

Further Uses of the Analog Computer as a Teaching Tool

ERIC Educational Resources Information Center

Shonle, John I.

1976-01-01

Discusses the use of an analog computer oscilloscope to illustrate the transition from underdamped to overdamped for the simple harmonic oscillator, the maximum range for a projectile, and the behavior of charged particles in crossed electric and magnetic fields. (MLH)

Ultra-low-energy analog straintronics using multiferroic composites

NASA Astrophysics Data System (ADS)

Roy, Kuntal

2014-03-01

Multiferroic devices, i.e., a magnetostrictive nanomagnet strain-coupled with a piezoelectric layer, are promising as binary switches for ultra-low-energy digital computing in beyond Moore's law era [Roy, K. Appl. Phys. Lett. 103, 173110 (2013), Roy, K. et al. Appl. Phys. Lett. 99, 063108 (2011), Phys. Rev. B 83, 224412 (2011), Scientific Reports (Nature Publishing Group) 3, 3038 (2013), J. Appl. Phys. 112, 023914 (2012)]. We show here that such multiferroic devices, apart from performing digital computation, can be also utilized for analog computing purposes, e.g., voltage amplification, filter etc. The analog computing capability is conceived by considering that magnetization's mean orientation shifts gradually although nanomagnet's potential minima changes abruptly. Using tunneling magnetoresistance (TMR) measurement, a continuous output voltage while varying the input voltage can be produced. Stochastic Landau-Lifshitz-Gilbert (LLG) equation in the presence of room-temperature (300 K) thermal fluctuations is solved to demonstrate the analog computing capability of such multiferroic devices. This work was supported in part by FAME, one of six centers of STARnet, a Semiconductor Research Corporation program sponsored by MARCO and DARPA.

Xyce parallel electronic simulator : users' guide.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mei, Ting; Rankin, Eric Lamont; Thornquist, Heidi K.

2011-05-01

This manual describes the use of the Xyce Parallel Electronic Simulator. Xyce has been designed as a SPICE-compatible, high-performance analog circuit simulator, and has been written to support the simulation needs of the Sandia National Laboratories electrical designers. This development has focused on improving capability over the current state-of-the-art in the following areas: (1) Capability to solve extremely large circuit problems by supporting large-scale parallel computing platforms (up to thousands of processors). Note that this includes support for most popular parallel and serial computers; (2) Improved performance for all numerical kernels (e.g., time integrator, nonlinear and linear solvers) through state-of-the-artmore » algorithms and novel techniques. (3) Device models which are specifically tailored to meet Sandia's needs, including some radiation-aware devices (for Sandia users only); and (4) Object-oriented code design and implementation using modern coding practices that ensure that the Xyce Parallel Electronic Simulator will be maintainable and extensible far into the future. Xyce is a parallel code in the most general sense of the phrase - a message passing parallel implementation - which allows it to run efficiently on the widest possible number of computing platforms. These include serial, shared-memory and distributed-memory parallel as well as heterogeneous platforms. Careful attention has been paid to the specific nature of circuit-simulation problems to ensure that optimal parallel efficiency is achieved as the number of processors grows. The development of Xyce provides a platform for computational research and development aimed specifically at the needs of the Laboratory. With Xyce, Sandia has an 'in-house' capability with which both new electrical (e.g., device model development) and algorithmic (e.g., faster time-integration methods, parallel solver algorithms) research and development can be performed. As a result, Xyce is a unique electrical simulation capability, designed to meet the unique needs of the laboratory.« less

Hierarchical CAD Tools for Radiation Hardened Mixed Signal Electronic Circuits

DTIC Science & Technology

2005-01-28

11 Figure 3: Schematic of Analog and Digital Components 12 Figure 4: Dose Rate Syntax 14 Figure 5: Single Event Effects (SEE) Syntax 15 Figure 6...Harmony-AMS simulation of a Digital Phase Locked Loop 19 Figure 10: SEE results from DPLL Simulation 20 Figure 11: Published results used for validation...analog and digital circuitry. Combining the analog and digital elements onto a single chip has several advantages, but also creates unique challenges

Simulation of arthroscopic surgery using MRI data

NASA Technical Reports Server (NTRS)

Heller, Geoffrey; Genetti, Jon

1994-01-01

With the availability of Magnetic Resonance Imaging (MRI) technology in the medical field and the development of powerful graphics engines in the computer world the possibility now exists for the simulation of surgery using data obtained from an actual patient. This paper describes a surgical simulation system which will allow a physician or a medical student to practice surgery on a patient without ever entering an operating room. This could substantially lower the cost of medial training by providing an alternative to the use of cadavers. This project involves the use of volume data acquired by MRI which are converted to polygonal form using a corrected marching cubes algorithm. The data are then colored and a simulation of surface response based on springy structures is performed in real time. Control for the system is obtained through the use of an attached analog-to-digital unit. A remote electronic device is described which simulates an imaginary tool having features in common with both arthroscope and laparoscope.

Evaluation of null-point detection methods on simulation data

NASA Astrophysics Data System (ADS)

Olshevsky, Vyacheslav; Fu, Huishan; Vaivads, Andris; Khotyaintsev, Yuri; Lapenta, Giovanni; Markidis, Stefano

2014-05-01

We model the measurements of artificial spacecraft that resemble the configuration of CLUSTER propagating in the particle-in-cell simulation of turbulent magnetic reconnection. The simulation domain contains multiple isolated X-type null-points, but the majority are O-type null-points. Simulations show that current pinches surrounded by twisted fields, analogous to laboratory pinches, are formed along the sequences of O-type nulls. In the simulation, the magnetic reconnection is mainly driven by the kinking of the pinches, at spatial scales of several ion inertial lentghs. We compute the locations of magnetic null-points and detect their type. When the satellites are separated by the fractions of ion inertial length, as it is for CLUSTER, they are able to locate both the isolated null-points, and the pinches. We apply the method to the real CLUSTER data and speculate how common are pinches in the magnetosphere, and whether they play a dominant role in the dissipation of magnetic energy.

A digitalized silicon microgyroscope based on embedded FPGA.

PubMed

Xia, Dunzhu; Yu, Cheng; Wang, Yuliang

2012-09-27

This paper presents a novel digital miniaturization method for a prototype silicon micro-gyroscope (SMG) with the symmetrical and decoupled structure. The schematic blocks of the overall system consist of high precision analog front-end interface, high-speed 18-bit analog to digital convertor, a high-performance core Field Programmable Gate Array (FPGA) chip and other peripherals such as high-speed serial ports for transmitting data. In drive mode, the closed-loop drive circuit are implemented by automatic gain control (AGC) loop and software phase-locked loop (SPLL) based on the Coordinated Rotation Digital Computer (CORDIC) algorithm. Meanwhile, the sense demodulation module based on varying step least mean square demodulation (LMSD) are addressed in detail. All kinds of algorithms are simulated by Simulink and DSPbuilder tools, which is in good agreement with the theoretical design. The experimental results have fully demonstrated the stability and flexibility of the system.

A Digitalized Silicon Microgyroscope Based on Embedded FPGA

PubMed Central

Xia, Dunzhu; Yu, Cheng; Wang, Yuliang

2012-01-01

This paper presents a novel digital miniaturization method for a prototype silicon micro-gyroscope (SMG) with the symmetrical and decoupled structure. The schematic blocks of the overall system consist of high precision analog front-end interface, high-speed 18-bit analog to digital convertor, a high-performance core Field Programmable Gate Array (FPGA) chip and other peripherals such as high-speed serial ports for transmitting data. In drive mode, the closed-loop drive circuit are implemented by automatic gain control (AGC) loop and software phase-locked loop (SPLL) based on the Coordinated Rotation Digital Computer (CORDIC) algorithm. Meanwhile, the sense demodulation module based on varying step least mean square demodulation (LMSD) are addressed in detail. All kinds of algorithms are simulated by Simulink and DSPbuilder tools, which is in good agreement with the theoretical design. The experimental results have fully demonstrated the stability and flexibility of the system. PMID:23201990

Magnetic suspension system for an Annular Momentum Control Device (AMCD)

NASA Technical Reports Server (NTRS)

1979-01-01

A technique to control a rim suspended in a magnetic field was developed. A complete system was developed, incorporating a support structure, magnetic actuators, a rim drive mechanism, an emergency fail-safe system, servo control system, and control electronics. Open loop and closed loop response of the system at zero speed and at 500 revolutions per minute (r/min) of the rim was obtained and analyzed. The rim was then dynamically balanced and a rim speed of 725 r/min was achieved. An analog simulation of the hardware was developed and tested with the actual control electronics connected to the analog computer. The system under development is stable at rim speeds below 700 r/min. Test results indicate that the rim under test is not rigid. The rim has a warp and a number of binding modes which prevented achievement of higher speeds. Further development efforts are required to achieve higher rim speeds.

Temporal coding in a silicon network of integrate-and-fire neurons.

PubMed

Liu, Shih-Chii; Douglas, Rodney

2004-09-01

Spatio-temporal processing of spike trains by neuronal networks depends on a variety of mechanisms distributed across synapses, dendrites, and somata. In natural systems, the spike trains and the processing mechanisms cohere though their common physical instantiation. This coherence is lost when the natural system is encoded for simulation on a general purpose computer. By contrast, analog VLSI circuits are, like neurons, inherently related by their real-time physics, and so, could provide a useful substrate for exploring neuronlike event-based processing. Here, we describe a hybrid analog-digital VLSI chip comprising a set of integrate-and-fire neurons and short-term dynamical synapses that can be configured into simple network architectures with some properties of neocortical neuronal circuits. We show that, despite considerable fabrication variance in the properties of individual neurons, the chip offers a viable substrate for exploring real-time spike-based processing in networks of neurons.

A visually guided collision warning system with a neuromorphic architecture.

PubMed

Okuno, Hirotsugu; Yagi, Tetsuya

2008-12-01

We have designed a visually guided collision warning system with a neuromorphic architecture, employing an algorithm inspired by the visual nervous system of locusts. The system was implemented with mixed analog-digital integrated circuits consisting of an analog resistive network and field-programmable gate array (FPGA) circuits. The resistive network processes the interaction between the laterally spreading excitatory and inhibitory signals instantaneously, which is essential for real-time computation of collision avoidance with a low power consumption and a compact hardware. The system responded selectively to approaching objects of simulated movie images at close range. The system was, however, confronted with serious noise problems due to the vibratory ego-motion, when it was installed in a mobile miniature car. To overcome this problem, we developed the algorithm, which is also installable in FPGA circuits, in order for the system to respond robustly during the ego-motion.

Noise Prediction of NASA SR2 Propeller in Transonic Conditions

NASA Astrophysics Data System (ADS)

Gennaro, Michele De; Caridi, Domenico; Nicola, Carlo De

2010-09-01

In this paper we propose a numerical approach for noise prediction of high-speed propellers for Turboprop applications. It is based on a RANS approach for aerodynamic simulation coupled with Ffowcs Williams-Hawkings (FW-H) Acoustic Analogy for propeller noise prediction. The test-case geometry adopted for this study is the 8-bladed NASA SR2 transonic cruise propeller, and simulated Sound Pressure Levels (SPL) have been compared with experimental data available from Wind Tunnel and Flight Tests for different microphone locations in a range of Mach numbers between 0.78 and 0.85 and rotational velocities between 7000 and 9000 rpm. Results show the ability of this approach to predict noise to within a few dB of experimental data. Moreover corrections are provided to be applied to acoustic numerical results in order for them to be compared with Wind Tunnel and Flight Test experimental data, as well computational grid requirements and guidelines in order to perform complete aerodynamic and aeroacoustic calculations with highly competitive computational cost.

Structural and Optical Properties Studies Of Ar2+ Ion Implanted Mn Deposited GaAs

NASA Astrophysics Data System (ADS)

De Gennaro, Michele; Caridi, Domenico; de Nicola, Carlo

2010-09-01

In this paper we propose a numerical approach for noise prediction of high-speed propellers for Turboprop applications. It is based on a RANS approach for aerodynamic simulation coupled with Ffowcs Williams-Hawkings (FW-H) Acoustic Analogy for propeller noise prediction. The test-case geometry adopted for this study is the 8-bladed NASA SR2 transonic cruise propeller, and simulated Sound Pressure Levels (SPL) have been compared with experimental data available from Wind Tunnel and Flight Tests for different microphone locations in a range of Mach numbers between 0.78 and 0.85 and rotational velocities between 7000 and 9000 rpm. Results show the ability of this approach to predict noise to within a few dB of experimental data. Moreover corrections are provided to be applied to acoustic numerical results in order for them to be compared with Wind Tunnel and Flight Test experimental data, as well computational grid requirements and guidelines in order to perform complete aerodynamic and aeroacoustic calculations with highly competitive computational cost.

Conway's "Game of Life" and the Epigenetic Principle.

PubMed

Caballero, Lorena; Hodge, Bob; Hernandez, Sergio

2016-01-01

Cellular automatons and computer simulation games are widely used as heuristic devices in biology, to explore implications and consequences of specific theories. Conway's Game of Life has been widely used for this purpose. This game was designed to explore the evolution of ecological communities. We apply it to other biological processes, including symbiopoiesis. We show that Conway's organization of rules reflects the epigenetic principle, that genetic action and developmental processes are inseparable dimensions of a single biological system, analogous to the integration processes in symbiopoiesis. We look for similarities and differences between two epigenetic models, by Turing and Edelman, as they are realized in Game of Life objects. We show the value of computer simulations to experiment with and propose generalizations of broader scope with novel testable predictions. We use the game to explore issues in symbiopoiesis and evo-devo, where we explore a fractal hypothesis: that self-similarity exists at different levels (cells, organisms, ecological communities) as a result of homologous interactions of two as processes modeled in the Game of Life.

Electronic neural networks for global optimization

NASA Technical Reports Server (NTRS)

Thakoor, A. P.; Moopenn, A. W.; Eberhardt, S.

1990-01-01

An electronic neural network with feedback architecture, implemented in analog custom VLSI is described. Its application to problems of global optimization for dynamic assignment is discussed. The convergence properties of the neural network hardware are compared with computer simulation results. The neural network's ability to provide optimal or near optimal solutions within only a few neuron time constants, a speed enhancement of several orders of magnitude over conventional search methods, is demonstrated. The effect of noise on the circuit dynamics and the convergence behavior of the neural network hardware is also examined.

IEEE 1982. Proceedings of the international conference on cybernetics and society

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1982-01-01

The following topics were dealt with: knowledge-based systems; risk analysis; man-machine interactions; human information processing; metaphor, analogy and problem-solving; manual control modelling; transportation systems; simulation; adaptive and learning systems; biocybernetics; cybernetics; mathematical programming; robotics; decision support systems; analysis, design and validation of models; computer vision; systems science; energy systems; environmental modelling and policy; pattern recognition; nuclear warfare; technological forecasting; artificial intelligence; the Turin shroud; optimisation; workloads. Abstracts of individual papers can be found under the relevant classification codes in this or future issues.

Proceedings of the International Conference on Recent Advances in Structural Dynamics (3rd) Held in Southampton, England on 18-22 July 1988. Volume 2

DTIC Science & Technology

1988-07-01

Mallik and Ghosh f71, Haddow, Barr and Nook [81, Miles [9), and Nayfeh [10). Four first-order ordinary differential equations that describe the...amplitude- and phase-modulated responses in their analog-computer simulations of a special form of equations (1) and (2). Hatwal, Mallik and Ghosh [71...BAJAJ 1978 Journal of Applied Mechanics 43, 895- 902. Bifurcations in dynamical systems with internal resonance. 7. H. HATWAL, A. K. MALLIK and A

Periodic control of the individual-blade-control helicopter rotor

NASA Technical Reports Server (NTRS)

Mckillip, R. M., Jr.

1985-01-01

This paper describes the results of an investigation into methods of controller design for linear periodic systems utilizing an extension of modern control methods. Trends present in the selection of various cost functions are outlined, and closed-loop controller results are demonstrated for two cases: first, on an analog computer simulation of the rigid out of plane flapping dynamics of a single rotor blade, and second, on a 4 ft diameter single-bladed model helicopter rotor in the MIT 5 x 7 subsonic wind tunnel, both for various high levels of advance ratio. It is shown that modal control using the IBC concept is possible over a large range of advance ratios with only a modest amount of computational power required.

Force sharing in high-power parallel servo-actuators

NASA Technical Reports Server (NTRS)

Neal, T. P.

1974-01-01

The various existing force sharing schemes were examined by conducting a literature survey. A list of potentially applicable concepts was compiled from this survey, and a brief analysis was then made of each concept, which resulted in two competing schemes being selected for in-depth evaluation. A functional design of the equalization logic for the two schemes was undertaken and specific space shuttle application was chosen for experimental evaluation. The application was scaled down so that existing hardware could be utilized. Next, an analog computer study was conducted to evaluate the more important characteristics of the two competing force sharing schemes. On the basis of the computers study, a final configuration was selected. A load simulator was then designed to evaluate this configuration on actual hardware.

Artificial neuron operations and spike-timing-dependent plasticity using memristive devices for brain-inspired computing

NASA Astrophysics Data System (ADS)

Marukame, Takao; Nishi, Yoshifumi; Yasuda, Shin-ichi; Tanamoto, Tetsufumi

2018-04-01

The use of memristive devices for creating artificial neurons is promising for brain-inspired computing from the viewpoints of computation architecture and learning protocol. We present an energy-efficient multiplier accumulator based on a memristive array architecture incorporating both analog and digital circuitries. The analog circuitry is used to full advantage for neural networks, as demonstrated by the spike-timing-dependent plasticity (STDP) in fabricated AlO x /TiO x -based metal-oxide memristive devices. STDP protocols for controlling periodic analog resistance with long-range stability were experimentally verified using a variety of voltage amplitudes and spike timings.

Reasoning by analogy as an aid to heuristic theorem proving.

NASA Technical Reports Server (NTRS)

Kling, R. E.

1972-01-01

When heuristic problem-solving programs are faced with large data bases that contain numbers of facts far in excess of those needed to solve any particular problem, their performance rapidly deteriorates. In this paper, the correspondence between a new unsolved problem and a previously solved analogous problem is computed and invoked to tailor large data bases to manageable sizes. This paper outlines the design of an algorithm for generating and exploiting analogies between theorems posed to a resolution-logic system. These algorithms are believed to be the first computationally feasible development of reasoning by analogy to be applied to heuristic theorem proving.

SSERVI Analog Regolith Simulant Testbed Facility

NASA Astrophysics Data System (ADS)

Minafra, J.; Schmidt, G. K.

2016-12-01

SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers. The SSERVI Analog Regolith Simulant Testbed provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment. The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area. SSERVI provides a bridge between several groups, joining together researchers from: 1) scientific and exploration communities, 2) multiple disciplines across a wide range of planetary sciences, and 3) domestic and international communities and partnerships. This testbed provides a means of consolidating the tasks of acquisition, storage and safety mitigation in handling large quantities of regolith simulant Facility hardware and environment testing scenarios include, but are not limited to the following; Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, and Surface features (i.e. grades and rocks) Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and planetary exploration activities at NASA Research Park, to academia and expanded commercial opportunities in California's Silicon Valley, as well as public outreach and education opportunities.

Towards fully analog hardware reservoir computing for speech recognition

NASA Astrophysics Data System (ADS)

Smerieri, Anteo; Duport, François; Paquot, Yvan; Haelterman, Marc; Schrauwen, Benjamin; Massar, Serge

2012-09-01

Reservoir computing is a very recent, neural network inspired unconventional computation technique, where a recurrent nonlinear system is used in conjunction with a linear readout to perform complex calculations, leveraging its inherent internal dynamics. In this paper we show the operation of an optoelectronic reservoir computer in which both the nonlinear recurrent part and the readout layer are implemented in hardware for a speech recognition application. The performance obtained is close to the one of to state-of-the-art digital reservoirs, while the analog architecture opens the way to ultrafast computation.

ROC Analysis of Chest Radiographs Using Computed Radiography and Conventional Analog Films

NASA Astrophysics Data System (ADS)

Morioka, Craig A.; Brown, Kathy; Hayrapetian, Alek S.; Kangarloo, Hooshang; Balter, Stephen; Huang, H. K.

1989-05-01

Receiver operating characteristic is used to compare the image quality of films obtained digitally using computed radiography (CR) and conventionally using analog film following fluoroscopic examination. Similar radiological views were obtained by both modalities. Twenty-four cases, some with a solitary noncalcified nodule and/or pneumothorax, were collected. Ten radiologists have been tested viewing analog and CR digital films separately. Final results indicate that there is no statistically significant difference in the ability to detect either a pneumothorax or a solitary noncalcified nodule when comparing CR digital film with conventional analog film. However, there is a trend that indicated the area under the ROC curves for detection of either a pneumothorax or solitary noncalcified nodule were greater for the analog film than for the digital film.

Determination of Fourier Transforms on an Instructional Analog Computer

ERIC Educational Resources Information Center

Anderson, Owen T.; Greenwood, Stephen R.

1974-01-01

An analog computer program to find and display the Fourier transform of some real, even functions is described. Oscilloscope traces are shown for Fourier transforms of a rectangular pulse, a Gaussian, a cosine wave, and a delayed narrow pulse. Instructional uses of the program are discussed briefly. (DT)

Simple Electronic Analog of a Josephson Junction.

ERIC Educational Resources Information Center

Henry, R. W.; And Others

1981-01-01

Demonstrates that an electronic Josephson junction analog constructed from three integrated circuits plus an external reference oscillator can exhibit many of the circuit phenomena of a real Josephson junction. Includes computer and other applications of the analog. (Author/SK)

Toward Wireless Health Monitoring via an Analog Signal Compression-Based Biosensing Platform.

PubMed

Zhao, Xueyuan; Sadhu, Vidyasagar; Le, Tuan; Pompili, Dario; Javanmard, Mehdi

2018-06-01

Wireless all-analog biosensor design for the concurrent microfluidic and physiological signal monitoring is presented in this paper. The key component is an all-analog circuit capable of compressing two analog sources into one analog signal by the analog joint source-channel coding (AJSCC). Two circuit designs are discussed, including the stacked-voltage-controlled voltage source (VCVS) design with the fixed number of levels, and an improved design, which supports a flexible number of AJSCC levels. Experimental results are presented on the wireless biosensor prototype, composed of printed circuit board realizations of the stacked-VCVS design. Furthermore, circuit simulation and wireless link simulation results are presented on the improved design. Results indicate that the proposed wireless biosensor is well suited for sensing two biological signals simultaneously with high accuracy, and can be applied to a wide variety of low-power and low-cost wireless continuous health monitoring applications.

Simulation-Based Airframe Noise Prediction of a Full-Scale, Full Aircraft

NASA Technical Reports Server (NTRS)

Khorrami, Mehdi R.; Fares, Ehab

2016-01-01

A previously validated computational approach applied to an 18%-scale, semi-span Gulfstream aircraft model was extended to the full-scale, full-span aircraft in the present investigation. The full-scale flap and main landing gear geometries used in the simulations are nearly identical to those flown on the actual aircraft. The lattice Boltzmann solver PowerFLOW® was used to perform time-accurate predictions of the flow field associated with this aircraft. The simulations were performed at a Mach number of 0.2 with the flap deflected 39 deg. and main landing gear deployed (landing configuration). Special attention was paid to the accurate prediction of major sources of flap tip and main landing gear noise. Computed farfield noise spectra for three selected baseline configurations (flap deflected 39 deg. with and without main gear extended, and flap deflected 0 deg. with gear deployed) are presented. The flap brackets are shown to be important contributors to the farfield noise spectra in the mid- to high-frequency range. Simulated farfield noise spectra for the baseline configurations, obtained using a Ffowcs Williams and Hawkings acoustic analogy approach, were found to be in close agreement with acoustic measurements acquired during the 2006 NASA-Gulfstream joint flight test of the same aircraft.

Experimental verification of a thermal equivalent circuit dynamic model on an extended range electric vehicle battery pack

NASA Astrophysics Data System (ADS)

Ramotar, Lokendra; Rohrauer, Greg L.; Filion, Ryan; MacDonald, Kathryn

2017-03-01

The development of a dynamic thermal battery model for hybrid and electric vehicles is realized. A thermal equivalent circuit model is created which aims to capture and understand the heat propagation from the cells through the entire pack and to the environment using a production vehicle battery pack for model validation. The inclusion of production hardware and the liquid battery thermal management system components into the model considers physical and geometric properties to calculate thermal resistances of components (conduction, convection and radiation) along with their associated heat capacity. Various heat sources/sinks comprise the remaining model elements. Analog equivalent circuit simulations using PSpice are compared to experimental results to validate internal temperature nodes and heat rates measured through various elements, which are then employed to refine the model further. Agreement with experimental results indicates the proposed method allows for a comprehensive real-time battery pack analysis at little computational expense when compared to other types of computer based simulations. Elevated road and ambient conditions in Mesa, Arizona are simulated on a parked vehicle with varying quiescent cooling rates to examine the effect on the diurnal battery temperature for longer term static exposure. A typical daily driving schedule is also simulated and examined.

In silico design and screening of hypothetical MOF-74 analogs and their experimental synthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witman, Matthew; Ling, Sanliang; Anderson, Samantha

2016-01-01

We present thein silico designof MOFs exhibiting 1-dimensional rod topologies by enumerating MOF-74-type analogs based on the PubChem Compounds database. We simulate the adsorption behavior of CO 2in the generated analogs and experimentally validate a novel MOF-74 analog, Mg 2(olsalazine).

Analog computation of auto and cross-correlation functions

NASA Technical Reports Server (NTRS)

1974-01-01

For analysis of the data obtained from the cross beam systems it was deemed desirable to compute the auto- and cross-correlation functions by both digital and analog methods to provide a cross-check of the analysis methods and an indication as to which of the two methods would be most suitable for routine use in the analysis of such data. It is the purpose of this appendix to provide a concise description of the equipment and procedures used for the electronic analog analysis of the cross beam data. A block diagram showing the signal processing and computation set-up used for most of the analog data analysis is provided. The data obtained at the field test sites were recorded on magnetic tape using wide-band FM recording techniques. The data as recorded were band-pass filtered by electronic signal processing in the data acquisition systems.

Synthetic analog computation in living cells.

PubMed

Daniel, Ramiz; Rubens, Jacob R; Sarpeshkar, Rahul; Lu, Timothy K

2013-05-30

A central goal of synthetic biology is to achieve multi-signal integration and processing in living cells for diagnostic, therapeutic and biotechnology applications. Digital logic has been used to build small-scale circuits, but other frameworks may be needed for efficient computation in the resource-limited environments of cells. Here we demonstrate that synthetic analog gene circuits can be engineered to execute sophisticated computational functions in living cells using just three transcription factors. Such synthetic analog gene circuits exploit feedback to implement logarithmically linear sensing, addition, ratiometric and power-law computations. The circuits exhibit Weber's law behaviour as in natural biological systems, operate over a wide dynamic range of up to four orders of magnitude and can be designed to have tunable transfer functions. Our circuits can be composed to implement higher-order functions that are well described by both intricate biochemical models and simple mathematical functions. By exploiting analog building-block functions that are already naturally present in cells, this approach efficiently implements arithmetic operations and complex functions in the logarithmic domain. Such circuits may lead to new applications for synthetic biology and biotechnology that require complex computations with limited parts, need wide-dynamic-range biosensing or would benefit from the fine control of gene expression.

Real-time modeling and simulation of distribution feeder and distributed resources

NASA Astrophysics Data System (ADS)

Singh, Pawan

The analysis of the electrical system dates back to the days when analog network analyzers were used. With the advent of digital computers, many programs were written for power-flow and short circuit analysis for the improvement of the electrical system. Real-time computer simulations can answer many what-if scenarios in the existing or the proposed power system. In this thesis, the standard IEEE 13-Node distribution feeder is developed and validated on a real-time platform OPAL-RT. The concept and the challenges of the real-time simulation are studied and addressed. Distributed energy resources include some of the commonly used distributed generation and storage devices like diesel engine, solar photovoltaic array, and battery storage system are modeled and simulated on a real-time platform. A microgrid encompasses a portion of an electric power distribution which is located downstream of the distribution substation. Normally, the microgrid operates in paralleled mode with the grid; however, scheduled or forced isolation can take place. In such conditions, the microgrid must have the ability to operate stably and autonomously. The microgrid can operate in grid connected and islanded mode, both the operating modes are studied in the last chapter. Towards the end, a simple microgrid controller modeled and simulated on the real-time platform is developed for energy management and protection for the microgrid.

Xyce Parallel Electronic Simulator Users' Guide Version 6.8

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keiter, Eric R.; Aadithya, Karthik Venkatraman; Mei, Ting

This manual describes the use of the Xyce Parallel Electronic Simulator. Xyce has been de- signed as a SPICE-compatible, high-performance analog circuit simulator, and has been written to support the simulation needs of the Sandia National Laboratories electrical designers. This development has focused on improving capability over the current state-of-the-art in the following areas: Capability to solve extremely large circuit problems by supporting large-scale parallel com- puting platforms (up to thousands of processors). This includes support for most popular parallel and serial computers. A differential-algebraic-equation (DAE) formulation, which better isolates the device model package from solver algorithms. This allows onemore » to develop new types of analysis without requiring the implementation of analysis-specific device models. Device models that are specifically tailored to meet Sandia's needs, including some radiation- aware devices (for Sandia users only). Object-oriented code design and implementation using modern coding practices. Xyce is a parallel code in the most general sense of the phrase$-$ a message passing parallel implementation $-$ which allows it to run efficiently a wide range of computing platforms. These include serial, shared-memory and distributed-memory parallel platforms. Attention has been paid to the specific nature of circuit-simulation problems to ensure that optimal parallel efficiency is achieved as the number of processors grows.« less

Numerical simulation of tonal fan noise of computers and air conditioning systems

NASA Astrophysics Data System (ADS)

Aksenov, A. A.; Gavrilyuk, V. N.; Timushev, S. F.

2016-07-01

Current approaches to fan noise simulation are mainly based on the Lighthill equation and socalled aeroacoustic analogy, which are also based on the transformed Lighthill equation, such as the wellknown FW-H equation or the Kirchhoff theorem. A disadvantage of such methods leading to significant modeling errors is associated with incorrect solution of the decomposition problem, i.e., separation of acoustic and vortex (pseudosound) modes in the area of the oscillation source. In this paper, we propose a method for tonal noise simulation based on the mesh solution of the Helmholtz equation for the Fourier transform of pressure perturbation with boundary conditions in the form of the complex impedance. A noise source is placed on the surface surrounding each fan rotor. The acoustic fan power is determined by the acoustic-vortex method, which ensures more accurate decomposition and determination of the pressure pulsation amplitudes in the near field of the fan.

Study of ceramic products and processing techniques in space. [using computerized simulation

NASA Technical Reports Server (NTRS)

Markworth, A. J.; Oldfield, W.

1974-01-01

An analysis of the solidification kinetics of beta alumina in a zero-gravity environment was carried out, using computer-simulation techniques, in order to assess the feasibility of producing high-quality single crystals of this material in space. The two coupled transport processes included were movement of the solid-liquid interface and diffusion of sodium atoms in the melt. Results of the simulation indicate that appreciable crystal-growth rates can be attained in space. Considerations were also made of the advantages offered by high-quality single crystals of beta alumina for use as a solid electrolyte; these clearly indicate that space-grown materials are superior in many respects to analogous terrestrially-grown crystals. Likewise, economic considerations, based on the rapidly expanding technological applications for beta alumina and related fast ionic conductors, reveal that the many superior qualities of space-grown material justify the added expense and experimental detail associated with space processing.

Digital optical conversion module

DOEpatents

Kotter, D.K.; Rankin, R.A.

1988-07-19

A digital optical conversion module used to convert an analog signal to a computer compatible digital signal including a voltage-to-frequency converter, frequency offset response circuitry, and an electrical-to-optical converter. Also used in conjunction with the digital optical conversion module is an optical link and an interface at the computer for converting the optical signal back to an electrical signal. Suitable for use in hostile environments having high levels of electromagnetic interference, the conversion module retains high resolution of the analog signal while eliminating the potential for errors due to noise and interference. The module can be used to link analog output scientific equipment such as an electrometer used with a mass spectrometer to a computer. 2 figs.

Digital optical conversion module

DOEpatents

Kotter, Dale K.; Rankin, Richard A.

1991-02-26

A digital optical conversion module used to convert an analog signal to a computer compatible digital signal including a voltage-to-frequency converter, frequency offset response circuitry, and an electrical-to-optical converter. Also used in conjunction with the digital optical conversion module is an optical link and an interface at the computer for converting the optical signal back to an electrical signal. Suitable for use in hostile environments having high levels of electromagnetic interference, the conversion module retains high resolution of the analog signal while eliminating the potential for errors due to noise and interference. The module can be used to link analog output scientific equipment such as an electrometer used with a mass spectrometer to a computer.

Large eddy simulation of trailing edge noise

NASA Astrophysics Data System (ADS)

Keller, Jacob; Nitzkorski, Zane; Mahesh, Krishnan

2015-11-01

Noise generation is an important engineering constraint to many marine vehicles. A significant portion of the noise comes from propellers and rotors, specifically due to flow interactions at the trailing edge. Large eddy simulation is used to investigate the noise produced by a turbulent 45 degree beveled trailing edge and a NACA 0012 airfoil. A porous surface Ffowcs-Williams and Hawkings acoustic analogy is combined with a dynamic endcapping method to compute the sound. This methodology allows for the impact of incident flow noise versus the total noise to be assessed. LES results for the 45 degree beveled trailing edge are compared to experiment at M = 0 . 1 and Rec = 1 . 9 e 6 . The effect of boundary layer thickness on sound production is investigated by computing using both the experimental boundary layer thickness and a thinner boundary layer. Direct numerical simulation results of the NACA 0012 are compared to available data at M = 0 . 4 and Rec = 5 . 0 e 4 for both the hydrodynamic field and the acoustic field. Sound intensities and directivities are investigated and compared. Finally, some of the physical mechanisms of far-field noise generation, common to the two configurations, are discussed. Supported by Office of Naval research.

Aerodynamic sound of flow past an airfoil

NASA Technical Reports Server (NTRS)

Wang, Meng

1995-01-01

The long term objective of this project is to develop a computational method for predicting the noise of turbulence-airfoil interactions, particularly at the trailing edge. We seek to obtain the energy-containing features of the turbulent boundary layers and the near-wake using Navier-Stokes Simulation (LES or DNS), and then to calculate the far-field acoustic characteristics by means of acoustic analogy theories, using the simulation data as acoustic source functions. Two distinct types of noise can be emitted from airfoil trailing edges. The first, a tonal or narrowband sound caused by vortex shedding, is normally associated with blunt trailing edges, high angles of attack, or laminar flow airfoils. The second source is of broadband nature arising from the aeroacoustic scattering of turbulent eddies by the trailing edge. Due to its importance to airframe noise, rotor and propeller noise, etc., trailing edge noise has been the subject of extensive theoretical (e.g. Crighton & Leppington 1971; Howe 1978) as well as experimental investigations (e.g. Brooks & Hodgson 1981; Blake & Gershfeld 1988). A number of challenges exist concerning acoustic analogy based noise computations. These include the elimination of spurious sound caused by vortices crossing permeable computational boundaries in the wake, the treatment of noncompact source regions, and the accurate description of wave reflection by the solid surface and scattering near the edge. In addition, accurate turbulence statistics in the flow field are required for the evaluation of acoustic source functions. Major efforts to date have been focused on the first two challenges. To this end, a paradigm problem of laminar vortex shedding, generated by a two dimensional, uniform stream past a NACA0012 airfoil, is used to address the relevant numerical issues. Under the low Mach number approximation, the near-field flow quantities are obtained by solving the incompressible Navier-Stokes equations numerically at chord Reynolds number of 104. The far-field noise is computed using Curle's extension to the Lighthill analogy (Curle 1955). An effective method for separating the physical noise source from spurious boundary contributions is developed. This allows an accurate evaluation of the Reynolds stress volume quadrupoles, in addition to the more readily computable surface dipoles due to the unsteady lift and drag. The effect of noncompact source distribution on the far-field sound is assessed using an efficient integration scheme for the Curle integral, with full account of retarded-time variations. The numerical results confirm in quantitative terms that the far-field sound is dominated by the surface pressure dipoles at low Mach number. The techniques developed are applicable to a wide range of flows, including jets and mixing layers, where the Reynolds stress quadrupoles play a prominent or even dominant role in the overall sound generation.

Data acquisition instrument for EEG based on embedded system

NASA Astrophysics Data System (ADS)

Toresano, La Ode Husein Z.; Wijaya, Sastra Kusuma; Prawito, Sudarmaji, Arief; Syakura, Abdan; Badri, Cholid

2017-02-01

An electroencephalogram (EEG) is a device for measuring and recording the electrical activity of brain. The EEG data of signal can be used as a source of analysis for human brain function. The purpose of this study was to design a portable multichannel EEG based on embedded system and ADS1299. The ADS1299 is an analog front-end to be used as an Analog to Digital Converter (ADC) to convert analog signal of electrical activity of brain, a filter of electrical signal to reduce the noise on low-frequency band and a data communication to the microcontroller. The system has been tested to capture brain signal within a range of 1-20 Hz using the NETECH EEG simulator 330. The developed system was relatively high accuracy of more than 82.5%. The EEG Instrument has been successfully implemented to acquire the brain signal activity using a PC (Personal Computer) connection for displaying the recorded data. The final result of data acquisition has been processed using OpenBCI GUI (Graphical User Interface) based through real-time process for 8-channel signal acquisition, brain-mapping and power spectral decomposition signal using the standard FFT (Fast Fourier Transform) algorithm.

Comparison of numerical weather prediction based deterministic and probabilistic wind resource assessment methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Jie; Draxl, Caroline; Hopson, Thomas

Numerical weather prediction (NWP) models have been widely used for wind resource assessment. Model runs with higher spatial resolution are generally more accurate, yet extremely computational expensive. An alternative approach is to use data generated by a low resolution NWP model, in conjunction with statistical methods. In order to analyze the accuracy and computational efficiency of different types of NWP-based wind resource assessment methods, this paper performs a comparison of three deterministic and probabilistic NWP-based wind resource assessment methodologies: (i) a coarse resolution (0.5 degrees x 0.67 degrees) global reanalysis data set, the Modern-Era Retrospective Analysis for Research and Applicationsmore » (MERRA); (ii) an analog ensemble methodology based on the MERRA, which provides both deterministic and probabilistic predictions; and (iii) a fine resolution (2-km) NWP data set, the Wind Integration National Dataset (WIND) Toolkit, based on the Weather Research and Forecasting model. Results show that: (i) as expected, the analog ensemble and WIND Toolkit perform significantly better than MERRA confirming their ability to downscale coarse estimates; (ii) the analog ensemble provides the best estimate of the multi-year wind distribution at seven of the nine sites, while the WIND Toolkit is the best at one site; (iii) the WIND Toolkit is more accurate in estimating the distribution of hourly wind speed differences, which characterizes the wind variability, at five of the available sites, with the analog ensemble being best at the remaining four locations; and (iv) the analog ensemble computational cost is negligible, whereas the WIND Toolkit requires large computational resources. Future efforts could focus on the combination of the analog ensemble with intermediate resolution (e.g., 10-15 km) NWP estimates, to considerably reduce the computational burden, while providing accurate deterministic estimates and reliable probabilistic assessments.« less

BacNet and Analog/Digital Interfaces of the Building Controls Virtual Testbed

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nouidui, Thierry Stephane; Wetter, Michael; Li, Zhengwei

2011-11-01

This paper gives an overview of recent developments in the Building Controls Virtual Test Bed (BCVTB), a framework for co-simulation and hardware-in-the-loop. First, a general overview of the BCVTB is presented. Second, we describe the BACnet interface, a link which has been implemented to couple BACnet devices to the BCVTB. We present a case study where the interface was used to couple a whole building simulation program to a building control system to assess in real-time the performance of a real building. Third, we present the ADInterfaceMCC, an analog/digital interface that allows a USB-based analog/digital converter to be linked tomore » the BCVTB. In a case study, we show how the link was used to couple the analog/digital converter to a building simulation model for local loop control.« less

An Analogy-Based Computer Tutor for Remediating Physics Misconceptions. Draft.

ERIC Educational Resources Information Center

Murray, Tom; And Others

This paper evaluates the strengths and limitations of a computer tutor designed to help students understand physics concepts. The tutor uses a teaching strategy called "bridging analogies" that previous research has demonstrated to be successful in one-to-one tutoring. The strategy is designed to remedy misconceptions by appealing to existing…

Near-field noise of a single-rotation propfan at an angle of attack

NASA Technical Reports Server (NTRS)

Nallasamy, M.; Envia, E.; Clark, B. J.; Groeneweg, J. F.

1990-01-01

The near field noise characteristics of a propfan operating at an angle of attack are examined utilizing the unsteady pressure field obtained from a 3-D Euler simulation of the propfan flowfield. The near field noise is calculated employing three different procedures: a direct computation method in which the noise field is extracted directly from the Euler solution, and two acoustic-analogy-based frequency domain methods which utilize the computed unsteady pressure distribution on the propfan blades as the source term. The inflow angles considered are -0.4, 1.6, and 4.6 degrees. The results of the direct computation method and one of the frequency domain methods show qualitative agreement with measurements. They show that an increase in the inflow angle is accompanied by an increase in the sound pressure level at the outboard wing boom locations and a decrease in the sound pressure level at the (inboard) fuselage locations. The trends in the computed azimuthal directivities of the noise field also conform to the measured and expected results.

Reliability of analog quantum simulation

DOE PAGES

Sarovar, Mohan; Zhang, Jun; Zeng, Lishan

2017-01-03

Analog quantum simulators (AQS) will likely be the first nontrivial application of quantum technology for predictive simulation. However, there remain questions regarding the degree of confidence that can be placed in the results of AQS since they do not naturally incorporate error correction. Specifically, how do we know whether an analog simulation of a quantum model will produce predictions that agree with the ideal model in the presence of inevitable imperfections? At the same time there is a widely held expectation that certain quantum simulation questions will be robust to errors and perturbations in the underlying hardware. Resolving these twomore » points of view is a critical step in making the most of this promising technology. In this paper we formalize the notion of AQS reliability by determining sensitivity of AQS outputs to underlying parameters, and formulate conditions for robust simulation. Our approach naturally reveals the importance of model symmetries in dictating the robust properties. Finally, to demonstrate the approach, we characterize the robust features of a variety of quantum many-body models.« less

High-Threshold Fault-Tolerant Quantum Computation with Analog Quantum Error Correction

NASA Astrophysics Data System (ADS)

Fukui, Kosuke; Tomita, Akihisa; Okamoto, Atsushi; Fujii, Keisuke

2018-04-01

To implement fault-tolerant quantum computation with continuous variables, the Gottesman-Kitaev-Preskill (GKP) qubit has been recognized as an important technological element. However, it is still challenging to experimentally generate the GKP qubit with the required squeezing level, 14.8 dB, of the existing fault-tolerant quantum computation. To reduce this requirement, we propose a high-threshold fault-tolerant quantum computation with GKP qubits using topologically protected measurement-based quantum computation with the surface code. By harnessing analog information contained in the GKP qubits, we apply analog quantum error correction to the surface code. Furthermore, we develop a method to prevent the squeezing level from decreasing during the construction of the large-scale cluster states for the topologically protected, measurement-based, quantum computation. We numerically show that the required squeezing level can be relaxed to less than 10 dB, which is within the reach of the current experimental technology. Hence, this work can considerably alleviate this experimental requirement and take a step closer to the realization of large-scale quantum computation.

Automatic Generation of Analogy Questions for Student Assessment: An Ontology-Based Approach

ERIC Educational Resources Information Center

Alsubait, Tahani; Parsia, Bijan; Sattler, Uli

2012-01-01

Different computational models for generating analogies of the form "A is to B as C is to D" have been proposed over the past 35 years. However, analogy generation is a challenging problem that requires further research. In this article, we present a new approach for generating analogies in Multiple Choice Question (MCQ) format that can be used…

Can low-cost VOR and Omega receivers suffice for RNAV - A new computer-based navigation technique

NASA Technical Reports Server (NTRS)

Hollaar, L. A.

1978-01-01

It is shown that although RNAV is particularly valuable for the personal transportation segment of general aviation, it has not gained complete acceptance. This is due, in part, to its high cost and the necessary special-handling air traffic control. VOR/DME RNAV calculations are ideally suited for analog computers, and the use of microprocessor technology has been suggested for reducing RNAV costs. Three navigation systems, VOR, Omega, and DR, are compared for common navigational difficulties, such as station geometry, siting errors, ground disturbances, and terminal area coverage. The Kalman filtering technique is described with reference to the disadvantages when using a system including standard microprocessors. An integrated navigation system, using input data from various low-cost sensor systems, is presented and current simulation studies are noted.

Where to look? Automating attending behaviors of virtual human characters

NASA Technical Reports Server (NTRS)

Chopra Khullar, S.; Badler, N. I.

2001-01-01

This research proposes a computational framework for generating visual attending behavior in an embodied simulated human agent. Such behaviors directly control eye and head motions, and guide other actions such as locomotion and reach. The implementation of these concepts, referred to as the AVA, draws on empirical and qualitative observations known from psychology, human factors and computer vision. Deliberate behaviors, the analogs of scanpaths in visual psychology, compete with involuntary attention capture and lapses into idling or free viewing. Insights provided by implementing this framework are: a defined set of parameters that impact the observable effects of attention, a defined vocabulary of looking behaviors for certain motor and cognitive activity, a defined hierarchy of three levels of eye behavior (endogenous, exogenous and idling) and a proposed method of how these types interact.

Design of neurophysiologically motivated structures of time-pulse coded neurons

NASA Astrophysics Data System (ADS)

Krasilenko, Vladimir G.; Nikolsky, Alexander I.; Lazarev, Alexander A.; Lobodzinska, Raisa F.

2009-04-01

The common methodology of biologically motivated concept of building of processing sensors systems with parallel input and picture operands processing and time-pulse coding are described in paper. Advantages of such coding for creation of parallel programmed 2D-array structures for the next generation digital computers which require untraditional numerical systems for processing of analog, digital, hybrid and neuro-fuzzy operands are shown. The optoelectronic time-pulse coded intelligent neural elements (OETPCINE) simulation results and implementation results of a wide set of neuro-fuzzy logic operations are considered. The simulation results confirm engineering advantages, intellectuality, circuit flexibility of OETPCINE for creation of advanced 2D-structures. The developed equivalentor-nonequivalentor neural element has power consumption of 10mW and processing time about 10...100us.

Translational and rotational dynamics of monosaccharide solutions.

PubMed

Lelong, Gérald; Howells, W Spencer; Brady, John W; Talón, César; Price, David L; Saboungi, Marie-Louise

2009-10-01

Molecular dynamics computer simulations have been carried out on aqueous solutions of glucose at concentrations bracketing those previously measured with quasi-elastic neutron scattering (QENS), in order to investigate the motions and interactions of the sugar and water molecules. In addition, QENS measurements have been carried out on fructose solutions to determine whether the effects previously observed for glucose apply to monosaccharide solutions. The simulations indicate a dynamical analogy between higher solute concentration and lower temperature that could provide a key explanation of the bioprotective phenomena observed in many living organisms. The experimental results on fructose solutions show qualitatively similar behavior to the glucose solutions. The dynamics of the water molecules are essentially the same, while the translational diffusion of the sugar molecules is slightly faster in the fructose solutions.

A new controller for battery-powered electric vehicles

NASA Technical Reports Server (NTRS)

Belsterling, C. A.; Stone, J.

1980-01-01

This paper describes the development, under a NASA/DOE contract, of a new concept for efficient and reliable control of battery-powered vehicles. It avoids the detrimental effects of pulsed-power controllers like the SCR 'chopper' by using rotating machines to meter continuous currents to the traction motor. The concept is validated in a proof-of-principle demonstration system and a complete vehicle is simulated on an analog computer. Test results show exceptional promise for a full-scale system. Optimum control strategies to minimize controller weight are developed by means of the simulated vehicle. The design for an Engineering Model is then prepared in the form of a practical, compact two-bearing package with forced air cooling. Predicted performance is outstanding, with controller efficiency of over 90% at high speed.

Toward superconducting critical current by design

DOE PAGES

Sadovskyy, Ivan A.; Jia, Ying; Leroux, Maxime; ...

2016-03-31

The interaction of vortex matter with defects in applied superconductors directly determines their current carrying capacity. Defects range from chemically grown nanostructures and crystalline imperfections to the layered structure of the material itself. The vortex-defect interactions are non-additive in general, leading to complex dynamic behavior that has proven difficult to capture in analytical models. With recent rapid progress in computational powers, a new paradigm has emerged that aims at simulation assisted design of defect structures with predictable ‘critical-current-by-design’: analogous to the materials genome concept of predicting stable materials structures of interest. We demonstrate the feasibility of this paradigm by combiningmore » large-scale time-dependent Ginzburg-Landau numerical simulations with experiments on commercial high temperature superconductor (HTS) containing well-controlled correlated defects.« less

Binding free energies for nicotine analogs inhibiting cytochrome P450 2A6 by a combined use of molecular dynamics simulations and QM/MM-PBSA calculations.

PubMed

Lu, Haiting; Huang, Xiaoqin; AbdulHameed, Mohamed Diwan M; Zhan, Chang-Guo

2014-04-01

Molecular dynamics (MD) simulations and hybrid quantum mechanical/molecular mechanical (QM/MM) calculations have been performed to explore the dynamic behaviors of cytochrome P450 2A6 (CYP2A6) binding with nicotine analogs (that are typical inhibitors) and to calculate their binding free energies in combination with Poisson-Boltzmann surface area (PBSA) calculations. The combined MD simulations and QM/MM-PBSA calculations reveal that the most important structural parameters affecting the CYP2A6-inhibitor binding affinity are two crucial internuclear distances, that is, the distance between the heme iron atom of CYP2A6 and the coordinating atom of the inhibitor, and the hydrogen-bonding distance between the N297 side chain of CYP2A6 and the pyridine nitrogen of the inhibitor. The combined MD simulations and QM/MM-PBSA calculations have led to dynamic CYP2A6-inhibitor binding structures that are consistent with the observed dynamic behaviors and structural features of CYP2A6-inhibitor binding, and led to the binding free energies that are in good agreement with the experimentally-derived binding free energies. The agreement between the calculated binding free energies and the experimentally-derived binding free energies suggests that the combined MD and QM/MM-PBSA approach may be used as a valuable tool to accurately predict the CYP2A6-inhibitor binding affinities in future computational design of new, potent and selective CYP2A6 inhibitors. Copyright © 2014 Elsevier Ltd. All rights reserved.

The importance of explicitly mapping instructional analogies in science education

NASA Astrophysics Data System (ADS)

Asay, Loretta Johnson

Analogies are ubiquitous during instruction in science classrooms, yet research about the effectiveness of using analogies has produced mixed results. An aspect seldom studied is a model of instruction when using analogies. The few existing models for instruction with analogies have not often been examined quantitatively. The Teaching With Analogies (TWA) model (Glynn, 1991) is one of the models frequently cited in the variety of research about analogies. The TWA model outlines steps for instruction, including the step of explicitly mapping the features of the source to the target. An experimental study was conducted to examine the effects of explicitly mapping the features of the source and target in an analogy during computer-based instruction about electrical circuits. Explicit mapping was compared to no mapping and to a control with no analogy. Participants were ninth- and tenth-grade biology students who were each randomly assigned to one of three conditions (no analogy module, analogy module, or explicitly mapped analogy module) for computer-based instruction. Subjects took a pre-test before the instruction, which was used to assign them to a level of previous knowledge about electrical circuits for analysis of any differential effects. After the instruction modules, students took a post-test about electrical circuits. Two weeks later, they took a delayed post-test. No advantage was found for explicitly mapping the analogy. Learning patterns were the same, regardless of the type of instruction. Those who knew the least about electrical circuits, based on the pre-test, made the most gains. After the two-week delay, this group maintained the largest amount of their gain. Implications exist for science education classrooms, as analogy use should be based on research about effective practices. Further studies are suggested to foster the building of research-based models for classroom instruction with analogies.

The Computation of Orthogonal Independent Cluster Solutions and Their Oblique Analogs in Factor Analysis.

ERIC Educational Resources Information Center

Hofmann, Richard J.

A very general model for the computation of independent cluster solutions in factor analysis is presented. The model is discussed as being either orthogonal or oblique. Furthermore, it is demonstrated that for every orthogonal independent cluster solution there is an oblique analog. Using three illustrative examples, certain generalities are made…

Towards a computational- and algorithmic-level account of concept blending using analogies and amalgams

NASA Astrophysics Data System (ADS)

Besold, Tarek R.; Kühnberger, Kai-Uwe; Plaza, Enric

2017-10-01

Concept blending - a cognitive process which allows for the combination of certain elements (and their relations) from originally distinct conceptual spaces into a new unified space combining these previously separate elements, and enables reasoning and inference over the combination - is taken as a key element of creative thought and combinatorial creativity. In this article, we summarise our work towards the development of a computational-level and algorithmic-level account of concept blending, combining approaches from computational analogy-making and case-based reasoning (CBR). We present the theoretical background, as well as an algorithmic proposal integrating higher-order anti-unification matching and generalisation from analogy with amalgams from CBR. The feasibility of the approach is then exemplified in two case studies.

Precise attitude control of the Stanford relativity satellite.

NASA Technical Reports Server (NTRS)

Bull, J. S.; Debra, D. B.

1973-01-01

A satellite being designed by the Stanford University to measure (with extremely high precision) the effect of General Relativity is described. Specifically, the satellite will measure two relativistic precessions predicted by the theory: the geodetic effect (6.9 arcsec/yr), due solely to motion about the earth, and the motional effect (0.05 arcsec/yr), due to rotation of the earth. The gyro design requirements, including the requirement for precise attitude control and a dynamic model for attitude control synthesis, are discussed. Closed loop simulation of the satellite's natural dynamics on an analog computer is described.

Analysis of self-oscillating dc-to-dc converters

NASA Technical Reports Server (NTRS)

Burger, P.

1974-01-01

The basic operational characteristics of dc-to-dc converters are analyzed along with the basic physical characteristics of power converters. A simple class of dc-to-dc power converters are chosen which could satisfy any set of operating requirements, and three different controlling methods in this class are described in detail. Necessary conditions for the stability of these converters are measured through analog computer simulation whose curves are related to other operational characteristics, such as ripple and regulation. Further research is suggested for the solution of absolute stability and efficient physical design of this class of power converters.

A mixed analog/digital chaotic neuro-computer system for quadratic assignment problems.

PubMed

Horio, Yoshihiko; Ikeguchi, Tohru; Aihara, Kazuyuki

2005-01-01

We construct a mixed analog/digital chaotic neuro-computer prototype system for quadratic assignment problems (QAPs). The QAP is one of the difficult NP-hard problems, and includes several real-world applications. Chaotic neural networks have been used to solve combinatorial optimization problems through chaotic search dynamics, which efficiently searches optimal or near optimal solutions. However, preliminary experiments have shown that, although it obtained good feasible solutions, the Hopfield-type chaotic neuro-computer hardware system could not obtain the optimal solution of the QAP. Therefore, in the present study, we improve the system performance by adopting a solution construction method, which constructs a feasible solution using the analog internal state values of the chaotic neurons at each iteration. In order to include the construction method into our hardware, we install a multi-channel analog-to-digital conversion system to observe the internal states of the chaotic neurons. We show experimentally that a great improvement in the system performance over the original Hopfield-type chaotic neuro-computer is obtained. That is, we obtain the optimal solution for the size-10 QAP in less than 1000 iterations. In addition, we propose a guideline for parameter tuning of the chaotic neuro-computer system according to the observation of the internal states of several chaotic neurons in the network.

From neural oscillations to reasoning ability: Simulating the effect of the theta-to-gamma cycle length ratio on individual scores in a figural analogy test.

PubMed

Chuderski, Adam; Andrelczyk, Krzysztof

2015-02-01

Several existing computational models of working memory (WM) have predicted a positive relationship (later confirmed empirically) between WM capacity and the individual ratio of theta to gamma oscillatory band lengths. These models assume that each gamma cycle represents one WM object (e.g., a binding of its features), whereas the theta cycle integrates such objects into the maintained list. As WM capacity strongly predicts reasoning, it might be expected that this ratio also predicts performance in reasoning tasks. However, no computational model has yet explained how the differences in the theta-to-gamma ratio found among adult individuals might contribute to their scores on a reasoning test. Here, we propose a novel model of how WM capacity constraints figural analogical reasoning, aimed at explaining inter-individual differences in reasoning scores in terms of the characteristics of oscillatory patterns in the brain. In the model, the gamma cycle encodes the bindings between objects/features and the roles they play in the relations processed. Asynchrony between consecutive gamma cycles results from lateral inhibition between oscillating bindings. Computer simulations showed that achieving the highest WM capacity required reaching the optimal level of inhibition. When too strong, this inhibition eliminated some bindings from WM, whereas, when inhibition was too weak, the bindings became unstable and fell apart or became improperly grouped. The model aptly replicated several empirical effects and the distribution of individual scores, as well as the patterns of correlations found in the 100-people sample attempting the same reasoning task. Most importantly, the model's reasoning performance strongly depended on its theta-to-gamma ratio in same way as the performance of human participants depended on their WM capacity. The data suggest that proper regulation of oscillations in the theta and gamma bands may be crucial for both high WM capacity and effective complex cognition. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Towards Full Aircraft Airframe Noise Prediction: Lattice Boltzmann Simulations

NASA Technical Reports Server (NTRS)

Khorrami, Mehdi R.; Fares, Ehab; Casalino, Damiano

2014-01-01

Computational results for an 18%-scale, semi-span Gulfstream aircraft model are presented. Exa Corporation's lattice Boltzmann PowerFLOW(trademark) solver was used to perform time-dependent simulations of the flow field associated with this high-fidelity aircraft model. The simulations were obtained for free-air at a Mach number of 0.2 with the flap deflected at 39 deg (landing configuration). We focused on accurately predicting the prominent noise sources at the flap tips and main landing gear for the two baseline configurations, namely, landing flap setting without and with gear deployed. Capitalizing on the inherently transient nature of the lattice Boltzmann formulation, the complex time-dependent flow features associated with the flap were resolved very accurately and efficiently. To properly simulate the noise sources over a broad frequency range, the tailored grid was very dense near the flap inboard and outboard tips. Extensive comparison of the computed time-averaged and unsteady surface pressures with wind tunnel measurements showed excellent agreement for the global aerodynamic characteristics and the local flow field at the flap inboard and outboard tips and the main landing gear. In particular, the computed fluctuating surface pressure field for the flap agreed well with the measurements in both amplitude and frequency content, indicating that the prominent airframe noise sources at the tips were captured successfully. Gear-flap interaction effects were remarkably well predicted and were shown to affect only the inboard flap tip, altering the steady and unsteady pressure fields in that region. The simulated farfield noise spectra for both baseline configurations, obtained using a Ffowcs-Williams and Hawkings acoustic analogy approach, were shown to be in close agreement with measured values.

Vertical marginal gap evaluation of conventional cast and computer numeric controlled-milled titanium full-arch implant-supported frameworks.

PubMed

Alfadda, Sara A

2014-01-01

To use a novel approach to measure the amount of vertical marginal gap in computer numeric controlled (CNC)-milled titanium frameworks and conventional cast frameworks. Ten cast frameworks were fabricated on the mandibular master casts of 10 patients. Then, 10 CNC-milled titanium frameworks were fabricated by laser scanning the cast frameworks. The vertical marginal gap was measured and analyzed using the Contura-G2 coordinate measuring machine and special computer software. The CNC-milled titanium frameworks showed an overall reduced mean vertical gap compared with the cast frameworks in all five analogs. This difference was highly statistically significant in the distal analogs. The largest mean gap in the cast framework was recorded in the most distal analogs, and the least amount was in the middle analog. Neither of the two types of frameworks provided a completely gap-free superstructure. The CNCmilled titanium frameworks showed a significantly smaller vertical marginal gap than the cast frameworks.

The emergence of understanding in a computer model of concepts and analogy-making

NASA Astrophysics Data System (ADS)

Mitchell, Melanie; Hofstadter, Douglas R.

1990-06-01

This paper describes Copycat, a computer model of the mental mechanisms underlying the fluidity and adaptability of the human conceptual system in the context of analogy-making. Copycat creates analogies between idealized situations in a microworld that has been designed to capture and isolate many of the central issues of analogy-making. In Copycat, an understanding of the essence of a situation and the recognition of deep similarity between two superficially different situations emerge from the interaction of a large number of perceptual agents with an associative, overlapping, and context-sensitive network of concepts. Central features of the model are: a high degree of parallelism; competition and cooperation among a large number of small, locally acting agents that together create a global understanding of the situation at hand; and a computational temperature that measures the amount of perceptual organization as processing proceeds and that in turn controls the degree of randomness with which decisions are made in the system.

Simulation analysis of formycin 5?-monophosphate analog substrates in the ricin A-chain active site

NASA Astrophysics Data System (ADS)

Olson, Mark A.; Scovill, John P.; Hack, Dallas C.

1995-06-01

Ricin is an RNA N-glycosidase that hydrolyzes a single adenine base from a conserved loop of 28S ribosomal RNA, thus inactivating protein synthesis. Molecular-dynamics simulation methods are used to analyze the structural interactions and thermodynamics that govern the binding of formycin 5'-monophosphate (FMP) and several of its analogs to the active site of ricin A-chain. Simulations are carried out initiated from the X-ray crystal structure of the ricin-FMP complex with the ligand modeled as a dianion, monoanion and zwitterion. Relative changes in binding free energies are estimated for FMP analogs constructed from amino substitutions at the 2- and 2'-positions, and from hydroxyl substitution at the 2'-position.

Simulation analysis of formycin 5'-monophosphate analog substrates in the ricin A-chain active site.

PubMed

Olson, M A; Scovill, J P; Hack, D C

1995-06-01

Ricin is an RNA N-glycosidase that hydrolyzes a single adenine base from a conserved loop of 28S ribosomal RNA, thus inactivating protein synthesis. Molecular-dynamics simulation methods are used to analyze the structural interactions and thermodynamics that govern the binding of formycin 5'-monophosphate (FMP) and several of its analogs to the active site of ricin A-chain. Simulations are carried out initiated from the X-ray crystal structure of the ricin-FMP complex with the ligand modeled as a dianion, monoanion and zwitterion. Relative changes in binding free energies are estimated for FMP analogs constructed from amino substitutions at the 2- and 2'-positions, and from hydroxyl substitution at the 2'-position.

(Computational Toxicology) A systematic evaluation of analogs and automated read-across prediction of estrogenicity: A case study using hindered phenols

EPA Science Inventory

Read-across is an important data gap filling technique used within category and analog approaches for regulatory hazard identification and risk assessment. Although much technical guidance is available that describes how to develop category/analog approaches, practical principles...

Teaching Physics for Conceptual Understanding Exemplified for Einstein's Special Relativity

NASA Astrophysics Data System (ADS)

Undreiu, Lucian M.

2006-12-01

In most liberal arts colleges the prerequisites for College Physics, Introductory or Calculus based, are strictly related to Mathematics. As a state of fact, the majorities of the students perceive Physics as a conglomerate of mathematical equations, a collection of facts to be memorized and they regard Physics as one of the most difficult subjects. A change of this attitude towards Physics, and Science in general, is intrinsically connected with the promotion of conceptual understanding and stimulation of critical thinking. In such an environment, the educators are facilitators, rather than the source of knowledge. One good way of doing this is to challenge the students to think about what they see around them and to connect physics with the real world. Motivation occurs when students realize that what was learned is interesting and relevant. Visual teaching aids such as educational videos or computer simulations, as well as computer-assisted experiments, can greatly enhance the effectiveness of a science lecture or laboratory. Difficult topics can be discussed through animated analogies. Special Relativity is recognized as a challenging topic and is probably one of the most misunderstood theories of Physics. While understanding Special Relativity requires a detachment from ordinary perception and every day life notions, animated analogies can prove to be very successful in making difficult topics accessible.

Synthetic Analog and Digital Circuits for Cellular Computation and Memory

PubMed Central

Purcell, Oliver; Lu, Timothy K.

2014-01-01

Biological computation is a major area of focus in synthetic biology because it has the potential to enable a wide range of applications. Synthetic biologists have applied engineering concepts to biological systems in order to construct progressively more complex gene circuits capable of processing information in living cells. Here, we review the current state of computational genetic circuits and describe artificial gene circuits that perform digital and analog computation. We then discuss recent progress in designing gene circuits that exhibit memory, and how memory and computation have been integrated to yield more complex systems that can both process and record information. Finally, we suggest new directions for engineering biological circuits capable of computation. PMID:24794536

Design of a specialized computer for on-line monitoring of cardiac stroke volume

NASA Technical Reports Server (NTRS)

Webb, J. A., Jr.; Gebben, V. D.

1972-01-01

The design of a specialized analog computer for on-line determination of cardiac stroke volume by means of a modified version of the pressure pulse contour method is presented. The design consists of an analog circuit for computation and a timing circuit for detecting necessary events on the pressure waveform. Readouts of arterial pressures, systolic duration, heart rate, percent change in stroke volume, and percent change in cardiac output are provided for monitoring cardiac patients. Laboratory results showed that computational accuracy was within 3 percent, while animal experiments verified the operational capability of the computer. Patient safety considerations are also discussed.

Device simulation of GeSn/GeSiSn pocket n-type tunnel field-effect transistor for analog and RF applications

NASA Astrophysics Data System (ADS)

Wang, Suyuan; Zheng, Jun; Xue, Chunlai; Li, Chuanbo; Zuo, Yuhua; Cheng, Buwen; Wang, Qiming

2017-11-01

We present the device simulations of analog and radio frequency (RF) performances of four double-gate pocket n-type tunneling field-effect transistors (NTFETs). The direct current (DC), analog and RF performances of the Ge-homo, GeSn-homo, GeSn/Ge and GeSn/GeSiSn NTFETs, are compared. The GeSn NTFETs greatly improve the on-state current (ION) and average subthreshold slope (SS), when compared with the Ge NTFET. Moreover, the GeSn/GeSiSn NTFET has the largest intrinsic gain (Av), and exhibits a suppressed ambipolar behavior, improved cut-off frequency (fT), and gain bandwidth product (GBW), according to the analyzed analog and RF figures of merit (FOM). Therefore, it can be concluded that the GeSn/GeSiSn NTFET has great potential as a promising candidate for the realization of future generation low-power analog/RF applications.

Dynamic simulation of concentrated macromolecular solutions with screened long-range hydrodynamic interactions: Algorithm and limitations

PubMed Central

Ando, Tadashi; Chow, Edmond; Skolnick, Jeffrey

2013-01-01

Hydrodynamic interactions exert a critical effect on the dynamics of macromolecules. As the concentration of macromolecules increases, by analogy to the behavior of semidilute polymer solutions or the flow in porous media, one might expect hydrodynamic screening to occur. Hydrodynamic screening would have implications both for the understanding of macromolecular dynamics as well as practical implications for the simulation of concentrated macromolecular solutions, e.g., in cells. Stokesian dynamics (SD) is one of the most accurate methods for simulating the motions of N particles suspended in a viscous fluid at low Reynolds number, in that it considers both far-field and near-field hydrodynamic interactions. This algorithm traditionally involves an O(N3) operation to compute Brownian forces at each time step, although asymptotically faster but more complex SD methods are now available. Motivated by the idea of hydrodynamic screening, the far-field part of the hydrodynamic matrix in SD may be approximated by a diagonal matrix, which is equivalent to assuming that long range hydrodynamic interactions are completely screened. This approximation allows sparse matrix methods to be used, which can reduce the apparent computational scaling to O(N). Previously there were several simulation studies using this approximation for monodisperse suspensions. Here, we employ newly designed preconditioned iterative methods for both the computation of Brownian forces and the solution of linear systems, and consider the validity of this approximation in polydisperse suspensions. We evaluate the accuracy of the diagonal approximation method using an intracellular-like suspension. The diffusivities of particles obtained with this approximation are close to those with the original method. However, this approximation underestimates intermolecular correlated motions, which is a trade-off between accuracy and computing efficiency. The new method makes it possible to perform large-scale and long-time simulation with an approximate accounting of hydrodynamic interactions. PMID:24089734

Analogy Mapping Development for Learning Programming

NASA Astrophysics Data System (ADS)

Sukamto, R. A.; Prabawa, H. W.; Kurniawati, S.

2017-02-01

Programming skill is an important skill for computer science students, whereas nowadays, there many computer science students are lack of skills and information technology knowledges in Indonesia. This is contrary with the implementation of the ASEAN Economic Community (AEC) since the end of 2015 which is the qualified worker needed. This study provided an effort for nailing programming skills by mapping program code to visual analogies as learning media. The developed media was based on state machine and compiler principle and was implemented in C programming language. The state of every basic condition in programming were successful determined as analogy visualization.

ENGINEERING APPLICATIONS OF ANALOG COMPUTERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bryant, L.T.; Janicke, M.J.; Just, L.C.

1963-10-31

Six experiments from the fields of reactor engineering, heat transfer, and dynamics are presented to illustrate the engineering applications of analog computers. The steps required for producing the analog solution are shown, as well as complete information for duplicating the solution. Graphical results are provided. The experiments include: deceleration of a reactor control rod, pressure variations through a packed bed, reactor kinetics over many decades with thermal feedback, a vibrating system with two degrees of freedom, temperature distribution in a radiating fin, temperature distribution in an infinite slab considering variable thermal properties, and iodine -xenon buildup in a reactor. (M.C.G.)

GIM code user's manual for the STAR-100 computer. [for generating numerical analogs of the conversion laws

NASA Technical Reports Server (NTRS)

Spradley, L.; Pearson, M.

1979-01-01

The General Interpolants Method (GIM), a three dimensional, time dependent, hybrid procedure for generating numerical analogs of the conversion laws, is described. The Navier-Stokes equations written for an Eulerian system are considered. The conversion of the GIM code to the STAR-100 computer, and the implementation of 'GIM-ON-STAR' is discussed.

Spaceflight Sensorimotor Analogs: Simulating Acute and Adaptive Effects

NASA Technical Reports Server (NTRS)

Taylor, Laura C.; Harm, Deborah L.; Kozlovskaya, Inessa; Reschke, Millard F.; Wood, Scott J.

2009-01-01

Adaptive changes in sensorimotor function during spaceflight are reflected by spatial disorientation, motion sickness, gaze destabilization and decrements in balance, locomotion and eye-hand coordination that occur during and following transitions between different gravitational states. The purpose of this study was to conduct a meta-synthesis of data from spaceflight analogs to evaluate their effectiveness in simulating adaptive changes in sensorimotor function. METHODS. The analogs under review were categorized as either acute analogs used to simulate performance decrements accompanied with transient changes, or adaptive analogs used to drive sensorimotor learning to altered sensory feedback. The effectiveness of each analog was evaluated in terms of mechanisms of action, magnitude and time course of observed deficits compared to spaceflight data, and the effects of amplitude and exposure duration. RESULTS. Parabolic flight has been used extensively to examine effects of acute variation in gravitational loads, ranging from hypergravity to microgravity. More recently, galvanic vestibular stimulation has been used to elicit acute postural, locomotor and gaze dysfunction by disrupting vestibular afferents. Patient populations, e.g., with bilateral vestibular loss or cerebellar dysfunction, have been proposed to model acute sensorimotor dysfunction. Early research sponsored by NASA involved living onboard rotating rooms, which appeared to approximate the time course of adaptation and post-exposure recovery observed in astronauts following spaceflight. Exposure to different bed-rest paradigms (6 deg head down, dry immersion) result in similar motor deficits to that observed following spaceflight. Shorter adaptive analogs have incorporated virtual reality environments, visual distortion paradigms, exposure to conflicting tilt-translation cues, and exposure to 3Gx centrifugation. As with spaceflight, there is considerable variability in responses to most of the analogs reviewed. DISCUSSION. A true ground-based flight analog for sensorimotor function is not feasible. A combination of flight analogs; however, can be used to selectively mimic different aspects of the spaceflight-induced sensorimotor performance decrements.

Computation of the bluff-body sound generation by a self-consistent mean flow formulation

NASA Astrophysics Data System (ADS)

Fani, A.; Citro, V.; Giannetti, F.; Auteri, F.

2018-03-01

The sound generated by the flow around a circular cylinder is numerically investigated by using a finite-element method. In particular, we study the acoustic emissions generated by the flow past the bluff body at low Mach and Reynolds numbers. We perform a global stability analysis by using the compressible linearized Navier-Stokes equations. The resulting direct global mode provides detailed information related to the underlying hydrodynamic instability and data on the acoustic field generated. In order to recover the intensity of the produced sound, we apply the self-consistent model for non-linear saturation proposed by Mantič-Lugo, Arratia, and Gallaire ["Self-consistent mean flow description of the nonlinear saturation of the vortex shedding in the cylinder wake," Phys. Rev. Lett. 113, 084501 (2014)]. The application of this model allows us to compute the amplitude of the resulting linear mode and the effects of saturation on the mode structure and acoustic field. Our results show excellent agreement with those obtained by a full compressible simulation direct numerical simulation and those derived by the application of classical acoustic analogy formulations.

Conway's “Game of Life” and the Epigenetic Principle

PubMed Central

Caballero, Lorena; Hodge, Bob; Hernandez, Sergio

2016-01-01

Cellular automatons and computer simulation games are widely used as heuristic devices in biology, to explore implications and consequences of specific theories. Conway's Game of Life has been widely used for this purpose. This game was designed to explore the evolution of ecological communities. We apply it to other biological processes, including symbiopoiesis. We show that Conway's organization of rules reflects the epigenetic principle, that genetic action and developmental processes are inseparable dimensions of a single biological system, analogous to the integration processes in symbiopoiesis. We look for similarities and differences between two epigenetic models, by Turing and Edelman, as they are realized in Game of Life objects. We show the value of computer simulations to experiment with and propose generalizations of broader scope with novel testable predictions. We use the game to explore issues in symbiopoiesis and evo-devo, where we explore a fractal hypothesis: that self-similarity exists at different levels (cells, organisms, ecological communities) as a result of homologous interactions of two as processes modeled in the Game of Life PMID:27379213

The structure and stability of Si60 and Ge60 cages: a computational study.

PubMed

Chen, Zhongfang; Jiao, Haijun; Seifert, Gotthard; Horn, Anselm H C; Yu, Dengke; Clark, Tim; Thiel, Walter; von Ragué Schleyer, Paul

2003-06-01

Structural studies of fullerene-like Si(60) and Ge(60) cages using ab initio methods were augmented by density functional tight-binding molecular dynamics (DFTB-MD) simulations of finite temperature effects. Neither the perfect I(h) symmetry nor the distorted T(h) structures are true minima. The energies of both are high relative to distorted, lower symmetry minima, C(i) and T, respectively, which still preserve C(60)-type connectivity. Both Si(60) and Ge(60) favor C(i) symmetry cages in which Si and Ge vertexes exhibit either near-trigonal or pyramidal geometries. These structural variations imply significant reactivity differences between different positions. The small magnetic shielding effects (NICS) indicate that aromaticity is not important in these systems. The inorganic fullerene cages have lower stabilities compared with their carbon analogs. Si(60) is stable towards spontaneous disintegration up to 700 K according to DFTB-MD simulations, and thus has potential for experimental observation. In contrast, Ge(60) preserves its cage structure only up to 200 K. Copyright 2003 Wiley Periodicals, Inc. J Comput Chem 24: 948-953, 2003

Sensing Methods for Detecting Analog Television Signals

NASA Astrophysics Data System (ADS)

Rahman, Mohammad Azizur; Song, Chunyi; Harada, Hiroshi

This paper introduces a unified method of spectrum sensing for all existing analog television (TV) signals including NTSC, PAL and SECAM. We propose a correlation based method (CBM) with a single reference signal for sensing any analog TV signals. In addition we also propose an improved energy detection method. The CBM approach has been implemented in a hardware prototype specially designed for participating in Singapore TV white space (WS) test trial conducted by Infocomm Development Authority (IDA) of the Singapore government. Analytical and simulation results of the CBM method will be presented in the paper, as well as hardware testing results for sensing various analog TV signals. Both AWGN and fading channels will be considered. It is shown that the theoretical results closely match with those from simulations. Sensing performance of the hardware prototype will also be presented in fading environment by using a fading simulator. We present performance of the proposed techniques in terms of probability of false alarm, probability of detection, sensing time etc. We also present a comparative study of the various techniques.

Lightweight filter architecture for energy efficient mobile vehicle localization based on a distributed acoustic sensor network.

PubMed

Kim, Keonwook

2013-08-23

The generic properties of an acoustic signal provide numerous benefits for localization by applying energy-based methods over a deployed wireless sensor network (WSN). However, the signal generated by a stationary target utilizes a significant amount of bandwidth and power in the system without providing further position information. For vehicle localization, this paper proposes a novel proximity velocity vector estimator (PVVE) node architecture in order to capture the energy from a moving vehicle and reject the signal from motionless automobiles around the WSN node. A cascade structure between analog envelope detector and digital exponential smoothing filter presents the velocity vector-sensitive output with low analog circuit and digital computation complexity. The optimal parameters in the exponential smoothing filter are obtained by analytical and mathematical methods for maximum variation over the vehicle speed. For stationary targets, the derived simulation based on the acoustic field parameters demonstrates that the system significantly reduces the communication requirements with low complexity and can be expected to extend the operation time considerably.

Implementation study of an analog spiking neural network for assisting cardiac delay prediction in a cardiac resynchronization therapy device.

PubMed

Sun, Qing; Schwartz, François; Michel, Jacques; Herve, Yannick; Dalmolin, Renzo

2011-06-01

In this paper, we aim at developing an analog spiking neural network (SNN) for reinforcing the performance of conventional cardiac resynchronization therapy (CRT) devices (also called biventricular pacemakers). Targeting an alternative analog solution in 0.13- μm CMOS technology, this paper proposes an approach to improve cardiac delay predictions in every cardiac period in order to assist the CRT device to provide real-time optimal heartbeats. The primary analog SNN architecture is proposed and its implementation is studied to fulfill the requirement of very low energy consumption. By using the Hebbian learning and reinforcement learning algorithms, the intended adaptive CRT device works with different functional modes. The simulations of both learning algorithms have been carried out, and they were shown to demonstrate the global functionalities. To improve the realism of the system, we introduce various heart behavior models (with constant/variable heart rates) that allow pathologic simulations with/without noise on the signals of the input sensors. The simulations of the global system (pacemaker models coupled with heart models) have been investigated and used to validate the analog spiking neural network implementation.

All-optical analog-to-digital converter based on Kerr effect in photonic crystal

NASA Astrophysics Data System (ADS)

Jafari, Dariush; Nurmohammadi, Tofiq; Asadi, Mohammad Javad; Abbasian, Karim

2018-05-01

In this paper, a novel all-optical analog-to-digital converter (AOADC) is proposed and simulated for proof of principle. This AOADC is designed to operate in the range of telecom wavelength (1550 nm). A cavity made of nonlinear Kerr material in photonic crystal (PhC), is designed to achieve an optical analog-to-digital conversion with 1 Tera sample per second (TS/s) and the total footprint of 42 μm2 . The simulation is done using finite-difference time domain (FDTD) method.

Use of bias correction techniques to improve seasonal forecasts for reservoirs - A case-study in northwestern Mediterranean.

PubMed

Marcos, Raül; Llasat, Ma Carmen; Quintana-Seguí, Pere; Turco, Marco

2018-01-01

In this paper, we have compared different bias correction methodologies to assess whether they could be advantageous for improving the performance of a seasonal prediction model for volume anomalies in the Boadella reservoir (northwestern Mediterranean). The bias correction adjustments have been applied on precipitation and temperature from the European Centre for Middle-range Weather Forecasting System 4 (S4). We have used three bias correction strategies: two linear (mean bias correction, BC, and linear regression, LR) and one non-linear (Model Output Statistics analogs, MOS-analog). The results have been compared with climatology and persistence. The volume-anomaly model is a previously computed Multiple Linear Regression that ingests precipitation, temperature and in-flow anomaly data to simulate monthly volume anomalies. The potential utility for end-users has been assessed using economic value curve areas. We have studied the S4 hindcast period 1981-2010 for each month of the year and up to seven months ahead considering an ensemble of 15 members. We have shown that the MOS-analog and LR bias corrections can improve the original S4. The application to volume anomalies points towards the possibility to introduce bias correction methods as a tool to improve water resource seasonal forecasts in an end-user context of climate services. Particularly, the MOS-analog approach gives generally better results than the other approaches in late autumn and early winter. Copyright © 2017 Elsevier B.V. All rights reserved.

The Effect of Combining Analogy-Based Simulation and Laboratory Activities on Turkish Elementary School Students' Understanding of Simple Electric Circuits

ERIC Educational Resources Information Center

Unlu, Zeynep Koyunlu; Dokme, Ibilge

2011-01-01

The purpose of this study was to investigate whether the combination of both analogy-based simulation and laboratory activities as a teaching tool was more effective than utilizing them separately in teaching the concepts of simple electricity. The quasi-experimental design that involved 66 seventh grade students from urban Turkish elementary…

Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development.

PubMed

McKay, Dennis B; Chang, Cheng; González-Cestari, Tatiana F; McKay, Susan B; El-Hajj, Raed A; Bryant, Darrell L; Zhu, Michael X; Swaan, Peter W; Arason, Kristjan M; Pulipaka, Aravinda B; Orac, Crina M; Bergmeier, Stephen C

2007-05-01

As a novel approach to drug discovery involving neuronal nicotinic acetylcholine receptors (nAChRs), our laboratory targeted nonagonist binding sites (i.e., noncompetitive binding sites, negative allosteric binding sites) located on nAChRs. Cultured bovine adrenal cells were used as neuronal models to investigate interactions of 67 analogs of methyllycaconitine (MLA) on native alpha3beta4* nAChRs. The availability of large numbers of structurally related molecules presents a unique opportunity for the development of pharmacophore models for noncompetitive binding sites. Our MLA analogs inhibited nicotine-mediated functional activation of both native and recombinant alpha3beta4* nAChRs with a wide range of IC(50) values (0.9-115 microM). These analogs had little or no inhibitory effects on agonist binding to native or recombinant nAChRs, supporting noncompetitive inhibitory activity. Based on these data, two highly predictive 3D quantitative structure-activity relationship (comparative molecular field analysis and comparative molecular similarity index analysis) models were generated. These computational models were successfully validated and provided insights into the molecular interactions of MLA analogs with nAChRs. In addition, a pharmacophore model was constructed to analyze and visualize the binding requirements to the analog binding site. The pharmacophore model was subsequently applied to search structurally diverse molecular databases to prospectively identify novel inhibitors. The rapid identification of eight molecules from database mining and our successful demonstration of in vitro inhibitory activity support the utility of these computational models as novel tools for the efficient retrieval of inhibitors. These results demonstrate the effectiveness of computational modeling and pharmacophore development, which may lead to the identification of new therapeutic drugs that target novel sites on nAChRs.

Giant Impacts on Earth-Like Worlds

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2016-05-01

Earth has experienced a large number of impacts, from the cratering events that may have caused mass extinctions to the enormous impact believed to have formed the Moon. A new study examines whether our planets impact history is typical for Earth-like worlds.N-Body ChallengesTimeline placing the authors simulations in context of the history of our solar system (click for a closer look). [Quintana et al. 2016]The final stages of terrestrial planet formation are thought to be dominated by giant impacts of bodies in the protoplanetary disk. During this stage, protoplanets smash into one another and accrete, greatly influencing the growth, composition, and habitability of the final planets.There are two major challenges when simulating this N-body planet formation. The first is fragmentation: since computational time scales as N^2, simulating lots of bodies that split into many more bodies is very computationally intensive. For this reason, fragmentation is usually ignored; simulations instead assume perfect accretion during collisions.Total number of bodies remaining within the authors simulations over time, with fragmentation included (grey) and ignored (red). Both simulations result in the same final number of bodies, but the ones that include fragmentation take more time to reach that final number. [Quintana et al. 2016]The second challengeis that many-body systems are chaotic, which means its necessary to do a large number of simulations to make statistical statements about outcomes.Adding FragmentationA team of scientists led by Elisa Quintana (NASA NPP Senior Fellow at the Ames Research Center) has recently pushed at these challenges by modeling inner-planet formation using a code that does include fragmentation. The team ran 140 simulations with and 140 without the effects of fragmentation using similar initial conditions to understand how including fragmentation affects the outcome.Quintana and collaborators then used the fragmentation-inclusive simulations to examine the collisional histories of Earth-like planets that form. Their goal is to understand if our solar systems formation and evolution is typical or unique.How Common Are Giant Impacts?Histogram of the total number of giant impacts received by the 164 Earth-like worlds produced in the authors fragmentation-inclusive simulations. [Quintana et al. 2016]The authors find that including fragmentation does not affect the final number of planets that are formed in the simulation (an average of 34 in each system, consistent with our solar systems terrestrial planet count). But when fragmentation is included, fewer collisions end in merger which results in typical accretion timescales roughly doubling. So the effects of fragmentation influence the collisional history of the system and the length of time needed for the final system to form.Examining the 164 Earth-analogs produced in the fragmentation-inclusive simulations, Quintana and collaborators find that impacts large enough to completely strip a planets atmosphere are rare; fewer than 1% of the Earth-like worlds experienced this.But giant impacts that are able to strip ~50% of an Earth-analogs atmosphere roughly the energy of the giant impact thought to have formed our Moon are more common. Almost all of the authors Earth-analogs experienced at least 1 giant impact of this size in the 2-Gyr simulation, and the average Earth-like world experienced ~3 such impacts.These results suggest that our planets impact history with the Moon-forming impact likely being the last giant impact Earth experienced is fairly typical for Earth-like worlds. The outcomes also indicate that smaller impacts that are still potentially life-threatening are much more common than bulk atmospheric removal. Higher-resolution simulations could be used to examine such smaller impacts.CitationElisa V. Quintana et al 2016 ApJ 821 126. doi:10.3847/0004-637X/821/2/126

Computer-assisted design and finite element simulation of braces for the treatment of adolescent idiopathic scoliosis using a coronal plane radiograph and surface topography.

PubMed

Pea, Rany; Dansereau, Jean; Caouette, Christiane; Cobetto, Nikita; Aubin, Carl-Éric

2018-05-01

Orthopedic braces made by Computer-Aided Design and Manufacturing and numerical simulation were shown to improve spinal deformities correction in adolescent idiopathic scoliosis while using less material. Simulations with BraceSim (Rodin4D, Groupe Lagarrigue, Bordeaux, France) require a sagittal radiograph, not always available. The objective was to develop an innovative modeling method based on a single coronal radiograph and surface topography, and assess the effectiveness of braces designed with this approach. With a patient coronal radiograph and a surface topography, the developed method allowed the 3D reconstruction of the spine, rib cage and pelvis using geometric models from a database and a free form deformation technique. The resulting 3D reconstruction converted into a finite element model was used to design and simulate the correction of a brace. The developed method was tested with data from ten scoliosis cases. The simulated correction was compared to analogous simulations performed with a 3D reconstruction built using two radiographs and surface topography (validated gold standard reference). There was an average difference of 1.4°/1.7° for the thoracic/lumbar Cobb angle, and 2.6°/5.5° for the kyphosis/lordosis between the developed reconstruction method and the reference. The average difference of the simulated correction was 2.8°/2.4° for the thoracic/lumbar Cobb angles and 3.5°/5.4° the kyphosis/lordosis. This study showed the feasibility to design and simulate brace corrections based on a new modeling method with a single coronal radiograph and surface topography. This innovative method could be used to improve brace designs, at a lesser radiation dose for the patient. Copyright © 2018 Elsevier Ltd. All rights reserved.

Hierarchical random cellular neural networks for system-level brain-like signal processing.

PubMed

Kozma, Robert; Puljic, Marko

2013-09-01

Sensory information processing and cognition in brains are modeled using dynamic systems theory. The brain's dynamic state is described by a trajectory evolving in a high-dimensional state space. We introduce a hierarchy of random cellular automata as the mathematical tools to describe the spatio-temporal dynamics of the cortex. The corresponding brain model is called neuropercolation which has distinct advantages compared to traditional models using differential equations, especially in describing spatio-temporal discontinuities in the form of phase transitions. Phase transitions demarcate singularities in brain operations at critical conditions, which are viewed as hallmarks of higher cognition and awareness experience. The introduced Monte-Carlo simulations obtained by parallel computing point to the importance of computer implementations using very large-scale integration (VLSI) and analog platforms. Copyright © 2013 Elsevier Ltd. All rights reserved.

Hypersonic and transonic buzz measurements on the lower pitch flap of the M2-F2 lifting entry configuration

NASA Technical Reports Server (NTRS)

Warner, R. W.; Wilcox, P. R.

1972-01-01

Free-oscillation damping measurements at hypersonic and transonic Mach numbers are presented for the lower pitch flap of the M2-F2 reentry vehicle. For the flow and model conditions tested, the damping measurements indicate the absence of hypersonic buzz instability for flap rotation frequencies of 47.3 Hz, 153 Hz, and 360 Hz, the presence of transonic buzz for 47.3 Hz flap, and the absence of transonic buzz for a 115 Hz flap. There are not enough flap damping data for an error estimate based on repeatability, but a partial damping calibration is presented in which an analog computer simulation of random flap response for a known flap damping is fed into the autocorrelation computer and filter combination used for most of the damping measurements.

COED Transactions, Vol. IX, No. 3, March 1977. Evaluation of a Complex Variable Using Analog/Hybrid Computation Techniques.

ERIC Educational Resources Information Center

Marcovitz, Alan B., Ed.

Described is the use of an analog/hybrid computer installation to study those physical phenomena that can be described through the evaluation of an algebraic function of a complex variable. This is an alternative way to study such phenomena on an interactive graphics terminal. The typical problem used, involving complex variables, is that of…

Digital video technology, today and tomorrow

NASA Astrophysics Data System (ADS)

Liberman, J.

1994-10-01

Digital video is probably computing's fastest moving technology today. Just three years ago, the zenith of digital video technology on the PC was the successful marriage of digital text and graphics with analog audio and video by means of expensive analog laser disc players and video overlay boards. The state of the art involves two different approaches to fully digital video on computers: hardware-assisted and software-only solutions.

Analog optical computing primitives in silicon photonics

DOE PAGES

Jiang, Yunshan; DeVore, Peter T. S.; Jalali, Bahram

2016-03-15

Optical computing accelerators help alleviate bandwidth and power consumption bottlenecks in electronics. In this paper, we show an approach to implementing logarithmic-type analog co-processors in silicon photonics and use it to perform the exponentiation operation and the recovery of a signal in the presence of multiplicative distortion. Finally, the function is realized by exploiting nonlinear-absorption-enhanced Raman amplification saturation in a silicon waveguide.

Predicting Flow Reversals in a Computational Fluid Dynamics Simulated Thermosyphon Using Data Assimilation.

PubMed

Reagan, Andrew J; Dubief, Yves; Dodds, Peter Sheridan; Danforth, Christopher M

2016-01-01

A thermal convection loop is a annular chamber filled with water, heated on the bottom half and cooled on the top half. With sufficiently large forcing of heat, the direction of fluid flow in the loop oscillates chaotically, dynamics analogous to the Earth's weather. As is the case for state-of-the-art weather models, we only observe the statistics over a small region of state space, making prediction difficult. To overcome this challenge, data assimilation (DA) methods, and specifically ensemble methods, use the computational model itself to estimate the uncertainty of the model to optimally combine these observations into an initial condition for predicting the future state. Here, we build and verify four distinct DA methods, and then, we perform a twin model experiment with the computational fluid dynamics simulation of the loop using the Ensemble Transform Kalman Filter (ETKF) to assimilate observations and predict flow reversals. We show that using adaptively shaped localized covariance outperforms static localized covariance with the ETKF, and allows for the use of less observations in predicting flow reversals. We also show that a Dynamic Mode Decomposition (DMD) of the temperature and velocity fields recovers the low dimensional system underlying reversals, finding specific modes which together are predictive of reversal direction.

Predicting Flow Reversals in a Computational Fluid Dynamics Simulated Thermosyphon Using Data Assimilation

PubMed Central

Reagan, Andrew J.; Dubief, Yves; Dodds, Peter Sheridan; Danforth, Christopher M.

2016-01-01

A thermal convection loop is a annular chamber filled with water, heated on the bottom half and cooled on the top half. With sufficiently large forcing of heat, the direction of fluid flow in the loop oscillates chaotically, dynamics analogous to the Earth’s weather. As is the case for state-of-the-art weather models, we only observe the statistics over a small region of state space, making prediction difficult. To overcome this challenge, data assimilation (DA) methods, and specifically ensemble methods, use the computational model itself to estimate the uncertainty of the model to optimally combine these observations into an initial condition for predicting the future state. Here, we build and verify four distinct DA methods, and then, we perform a twin model experiment with the computational fluid dynamics simulation of the loop using the Ensemble Transform Kalman Filter (ETKF) to assimilate observations and predict flow reversals. We show that using adaptively shaped localized covariance outperforms static localized covariance with the ETKF, and allows for the use of less observations in predicting flow reversals. We also show that a Dynamic Mode Decomposition (DMD) of the temperature and velocity fields recovers the low dimensional system underlying reversals, finding specific modes which together are predictive of reversal direction. PMID:26849061

Synthetic analog and digital circuits for cellular computation and memory.

PubMed

Purcell, Oliver; Lu, Timothy K

2014-10-01

Biological computation is a major area of focus in synthetic biology because it has the potential to enable a wide range of applications. Synthetic biologists have applied engineering concepts to biological systems in order to construct progressively more complex gene circuits capable of processing information in living cells. Here, we review the current state of computational genetic circuits and describe artificial gene circuits that perform digital and analog computation. We then discuss recent progress in designing gene networks that exhibit memory, and how memory and computation have been integrated to yield more complex systems that can both process and record information. Finally, we suggest new directions for engineering biological circuits capable of computation. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Biased ART: a neural architecture that shifts attention toward previously disregarded features following an incorrect prediction.

PubMed

Carpenter, Gail A; Gaddam, Sai Chaitanya

2010-04-01

Memories in Adaptive Resonance Theory (ART) networks are based on matched patterns that focus attention on those portions of bottom-up inputs that match active top-down expectations. While this learning strategy has proved successful for both brain models and applications, computational examples show that attention to early critical features may later distort memory representations during online fast learning. For supervised learning, biased ARTMAP (bARTMAP) solves the problem of over-emphasis on early critical features by directing attention away from previously attended features after the system makes a predictive error. Small-scale, hand-computed analog and binary examples illustrate key model dynamics. Two-dimensional simulation examples demonstrate the evolution of bARTMAP memories as they are learned online. Benchmark simulations show that featural biasing also improves performance on large-scale examples. One example, which predicts movie genres and is based, in part, on the Netflix Prize database, was developed for this project. Both first principles and consistent performance improvements on all simulation studies suggest that featural biasing should be incorporated by default in all ARTMAP systems. Benchmark datasets and bARTMAP code are available from the CNS Technology Lab Website: http://techlab.bu.edu/bART/. Copyright 2009 Elsevier Ltd. All rights reserved.

Discrete stochastic analogs of Erlang epidemic models.

PubMed

Getz, Wayne M; Dougherty, Eric R

2018-12-01

Erlang differential equation models of epidemic processes provide more realistic disease-class transition dynamics from susceptible (S) to exposed (E) to infectious (I) and removed (R) categories than the ubiquitous SEIR model. The latter is itself is at one end of the spectrum of Erlang SE[Formula: see text]I[Formula: see text]R models with [Formula: see text] concatenated E compartments and [Formula: see text] concatenated I compartments. Discrete-time models, however, are computationally much simpler to simulate and fit to epidemic outbreak data than continuous-time differential equations, and are also much more readily extended to include demographic and other types of stochasticity. Here we formulate discrete-time deterministic analogs of the Erlang models, and their stochastic extension, based on a time-to-go distributional principle. Depending on which distributions are used (e.g. discretized Erlang, Gamma, Beta, or Uniform distributions), we demonstrate that our formulation represents both a discretization of Erlang epidemic models and generalizations thereof. We consider the challenges of fitting SE[Formula: see text]I[Formula: see text]R models and our discrete-time analog to data (the recent outbreak of Ebola in Liberia). We demonstrate that the latter performs much better than the former; although confining fits to strict SEIR formulations reduces the numerical challenges, but sacrifices best-fit likelihood scores by at least 7%.

Activated dynamics in dense fluids of attractive nonspherical particles. II. Elasticity, barriers, relaxation, fragility, and self-diffusion

NASA Astrophysics Data System (ADS)

Tripathy, Mukta; Schweizer, Kenneth S.

2011-04-01

In paper II of this series we apply the center-of-mass version of Nonlinear Langevin Equation theory to study how short-range attractive interactions influence the elastic shear modulus, transient localization length, activated dynamics, and kinetic arrest of a variety of nonspherical particle dense fluids (and the spherical analog) as a function of volume fraction and attraction strength. The activation barrier (roughly the natural logarithm of the dimensionless relaxation time) is predicted to be a rich function of particle shape, volume fraction, and attraction strength, and the dynamic fragility varies significantly with particle shape. At fixed volume fraction, the barrier grows in a parabolic manner with inverse temperature nondimensionalized by an onset value, analogous to what has been established for thermal glass-forming liquids. Kinetic arrest boundaries lie at significantly higher volume fractions and attraction strengths relative to their dynamic crossover analogs, but their particle shape dependence remains the same. A limited universality of barrier heights is found based on the concept of an effective mean-square confining force. The mean hopping time and self-diffusion constant in the attractive glass region of the nonequilibrium phase diagram is predicted to vary nonmonotonically with attraction strength or inverse temperature, qualitatively consistent with recent computer simulations and colloid experiments.

The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin

PubMed Central

Liu, Yan; Li, Nan; Qi, Yipin; Niu, Li-na; Elshafiy, Sally; Mao, Jing; Breschi, Lorenzo; Pashley, David H.; Tay, Franklin R.

2011-01-01

Objectives This study examined the use of sodium trimetaphosphate (STMP) as a biomimetic analog of matrix phosphoproteins for remineralization of artificial carious-affected dentin. Methods Artificial carious lesions with lesion depths of 300±30 µm were created by pH-cycling. 2.5% hydrolyzed STMP was applied to the artificial carious lesions to phosphorylate the partially-demineralized collagen matrix. Half of the STMP-treated specimens were bonded with One-Step. The adhesive and non-adhesive infiltrated specimens were remineralized in a Portland cement-simulated body fluid system containing polyacrylic acid (PAA) to stabilize amorphous calcium phosphate as nanoprecursors. Micro-computed tomography (micro-CT) and transmission electron microscopy (TEM) were used to evaluate the results of remineralization after a 4-month period. Results In absence of PAA and STMP as biomimetic analogs (control groups), there was no remineralization irrespective of whether the lesions were infiltrated with adhesive. For the STMP-treated experimental groups immersed in PAA-containing simulated body fluid, specimens without adhesive infiltration were more heavily remineralized than those infiltrated with adhesive. Statistical analysis of the 4-month micro-CT data revealed significant differences in the lesion depth, relative mineral content along the lesion surface and changes in ΔZ between the non-adhesive and adhesive experimental groups (p<0.05 for all the three parameters). TEM examination indicated that collagen degradation occurred in both the non-adhesive and adhesive control and experimental groups after 4 months of remineralization. Significance Biomimetic remineralization using STMP is a promising method to remineralize artificial carious lesions particularly in areas devoid of seed crystallites. Future studies should consider the incorporation of MMP-inhibitors within the partially-demineralized collagen matrix to prevent collagen degradation during remineralization. PMID:21354608

A parallel-pipelined architecture for a multi carrier demodulator

NASA Astrophysics Data System (ADS)

Kwatra, S. C.; Jamali, M. M.; Eugene, Linus P.

1991-03-01

Analog devices have been used for processing the information on board the satellites. Presently, digital devices are being used because they are economical and flexible as compared to their analog counterparts. Several schemes of digital transmission can be used depending on the data rate requirement of the user. An economical scheme of transmission for small earth stations uses single channel per carrier/frequency division multiple access (SCPC/FDMA) on the uplink and time division multiplexing (TDM) on the downlink. This is a typical communication service offered to low data rate users in commercial mass market. These channels usually pertain to either voice or data transmission. An efficient digital demodulator architecture is provided for a large number of law data rate users. A demodulator primarily consists of carrier, clock, and data recovery modules. This design uses principles of parallel processing, pipelining, and time sharing schemes to process large numbers of voice or data channels. It maintains the optimum throughput which is derived from the designed architecture and from the use of high speed components. The design is optimized for reduced power and area requirements. This is essential for satellite applications. The design is also flexible in processing a group of a varying number of channels. The algorithms that are used are verified by the use of a computer aided software engineering (CASE) tool called the Block Oriented System Simulator. The data flow, control circuitry, and interface of the hardware design is simulated in C language. Also, a multiprocessor approach is provided to map, model, and simulate the demodulation algorithms mainly from a speed view point. A hypercude based architecture implementation is provided for such a scheme of operation. The hypercube structure and the demodulation models on hypercubes are simulated in Ada.

A parallel-pipelined architecture for a multi carrier demodulator. M.S. Thesis Final Technical Report, Jan. 1989 - Aug. 1990

NASA Technical Reports Server (NTRS)

Kwatra, S. C.; Jamali, M. M.; Eugene, Linus P.

1991-01-01

Analog devices have been used for processing the information on board the satellites. Presently, digital devices are being used because they are economical and flexible as compared to their analog counterparts. Several schemes of digital transmission can be used depending on the data rate requirement of the user. An economical scheme of transmission for small earth stations uses single channel per carrier/frequency division multiple access (SCPC/FDMA) on the uplink and time division multiplexing (TDM) on the downlink. This is a typical communication service offered to low data rate users in commercial mass market. These channels usually pertain to either voice or data transmission. An efficient digital demodulator architecture is provided for a large number of law data rate users. A demodulator primarily consists of carrier, clock, and data recovery modules. This design uses principles of parallel processing, pipelining, and time sharing schemes to process large numbers of voice or data channels. It maintains the optimum throughput which is derived from the designed architecture and from the use of high speed components. The design is optimized for reduced power and area requirements. This is essential for satellite applications. The design is also flexible in processing a group of a varying number of channels. The algorithms that are used are verified by the use of a computer aided software engineering (CASE) tool called the Block Oriented System Simulator. The data flow, control circuitry, and interface of the hardware design is simulated in C language. Also, a multiprocessor approach is provided to map, model, and simulate the demodulation algorithms mainly from a speed view point. A hypercude based architecture implementation is provided for such a scheme of operation. The hypercube structure and the demodulation models on hypercubes are simulated in Ada.

Multi-Attribute Task Battery - Applications in pilot workload and strategic behavior research

NASA Technical Reports Server (NTRS)

Arnegard, Ruth J.; Comstock, J. R., Jr.

1991-01-01

The Multi-Attribute Task (MAT) Battery provides a benchmark set of tasks for use in a wide range of lab studies of operator performance and workload. The battery incorporates tasks analogous to activities that aircraft crewmembers perform in flight, while providing a high degree of experimenter control, performance data on each subtask, and freedom to nonpilot test subjects. Features not found in existing computer based tasks include an auditory communication task (to simulate Air Traffic Control communication), a resource management task permitting many avenues or strategies of maintaining target performance, a scheduling window which gives the operator information about future task demands, and the option of manual or automated control of tasks. Performance data are generated for each subtask. In addition, the task battery may be paused and onscreen workload rating scales presented to the subject. The MAT Battery requires a desktop computer with color graphics. The communication task requires a serial link to a second desktop computer with a voice synthesizer or digitizer card.

The multi-attribute task battery for human operator workload and strategic behavior research

NASA Technical Reports Server (NTRS)

Comstock, J. Raymond, Jr.; Arnegard, Ruth J.

1992-01-01

The Multi-Attribute Task (MAT) Battery provides a benchmark set of tasks for use in a wide range of lab studies of operator performance and workload. The battery incorporates tasks analogous to activities that aircraft crewmembers perform in flight, while providing a high degree of experimenter control, performance data on each subtask, and freedom to use nonpilot test subjects. Features not found in existing computer based tasks include an auditory communication task (to simulate Air Traffic Control communication), a resource management task permitting many avenues or strategies of maintaining target performance, a scheduling window which gives the operator information about future task demands, and the option of manual or automated control of tasks. Performance data are generated for each subtask. In addition, the task battery may be paused and onscreen workload rating scales presented to the subject. The MAT Battery requires a desktop computer with color graphics. The communication task requires a serial link to a second desktop computer with a voice synthesizer or digitizer card.

Variational approach to probabilistic finite elements

NASA Technical Reports Server (NTRS)

Belytschko, T.; Liu, W. K.; Mani, A.; Besterfield, G.

1991-01-01

Probabilistic finite element methods (PFEM), synthesizing the power of finite element methods with second-moment techniques, are formulated for various classes of problems in structural and solid mechanics. Time-invariant random materials, geometric properties and loads are incorporated in terms of their fundamental statistics viz. second-moments. Analogous to the discretization of the displacement field in finite element methods, the random fields are also discretized. Preserving the conceptual simplicity, the response moments are calculated with minimal computations. By incorporating certain computational techniques, these methods are shown to be capable of handling large systems with many sources of uncertainties. By construction, these methods are applicable when the scale of randomness is not very large and when the probabilistic density functions have decaying tails. The accuracy and efficiency of these methods, along with their limitations, are demonstrated by various applications. Results obtained are compared with those of Monte Carlo simulation and it is shown that good accuracy can be obtained for both linear and nonlinear problems. The methods are amenable to implementation in deterministic FEM based computer codes.

Variational approach to probabilistic finite elements

NASA Astrophysics Data System (ADS)

Belytschko, T.; Liu, W. K.; Mani, A.; Besterfield, G.

1991-08-01

Probabilistic finite element methods (PFEM), synthesizing the power of finite element methods with second-moment techniques, are formulated for various classes of problems in structural and solid mechanics. Time-invariant random materials, geometric properties and loads are incorporated in terms of their fundamental statistics viz. second-moments. Analogous to the discretization of the displacement field in finite element methods, the random fields are also discretized. Preserving the conceptual simplicity, the response moments are calculated with minimal computations. By incorporating certain computational techniques, these methods are shown to be capable of handling large systems with many sources of uncertainties. By construction, these methods are applicable when the scale of randomness is not very large and when the probabilistic density functions have decaying tails. The accuracy and efficiency of these methods, along with their limitations, are demonstrated by various applications. Results obtained are compared with those of Monte Carlo simulation and it is shown that good accuracy can be obtained for both linear and nonlinear problems. The methods are amenable to implementation in deterministic FEM based computer codes.

Variational approach to probabilistic finite elements

NASA Technical Reports Server (NTRS)

Belytschko, T.; Liu, W. K.; Mani, A.; Besterfield, G.

1987-01-01

Probabilistic finite element method (PFEM), synthesizing the power of finite element methods with second-moment techniques, are formulated for various classes of problems in structural and solid mechanics. Time-invariant random materials, geometric properties, and loads are incorporated in terms of their fundamental statistics viz. second-moments. Analogous to the discretization of the displacement field in finite element methods, the random fields are also discretized. Preserving the conceptual simplicity, the response moments are calculated with minimal computations. By incorporating certain computational techniques, these methods are shown to be capable of handling large systems with many sources of uncertainties. By construction, these methods are applicable when the scale of randomness is not very large and when the probabilistic density functions have decaying tails. The accuracy and efficiency of these methods, along with their limitations, are demonstrated by various applications. Results obtained are compared with those of Monte Carlo simulation and it is shown that good accuracy can be obtained for both linear and nonlinear problems. The methods are amenable to implementation in deterministic FEM based computer codes.

Design for pressure regulating components

NASA Technical Reports Server (NTRS)

Wichmann, H.

1973-01-01

The design development for Pressure Regulating Components included a regulator component trade-off study with analog computer performance verification to arrive at a final optimized regulator configuration for the Space Storable Propulsion Module, under development for a Jupiter Orbiter mission. This application requires the pressure regulator to be capable of long-term fluorine exposure. In addition, individual but basically identical (for purposes of commonality) units are required for separate oxidizer and fuel pressurization. The need for dual units requires improvement in the regulation accuracy over present designs. An advanced regulator concept was prepared featuring redundant bellows, all metallic/ceramic construction, friction-free guidance of moving parts, gas damping, and the elimination of coil springs normally used for reference forces. The activities included testing of actual size seat/poppet components to determine actual discharge coefficients and flow forces. The resulting data was inserted into the computer model of the regulator. Computer simulation of the propulsion module performance over two mission profiles indicated satisfactory minimization of propellant residual requirements imposed by regulator performance uncertainties.

A microprocessor-based real-time simulator of a turbofan engine

NASA Technical Reports Server (NTRS)

Litt, Jonathan S.; Delaat, John C.; Merrill, Walter C.

1988-01-01

A real-time digital simulator of a Pratt and Whitney F 100 engine is discussed. This self-contained unit can operate in an open-loop stand-alone mode or as part of a closed-loop control system. It can also be used in control system design and development. It accepts five analog control inputs and its sixteen outputs are returned as analog signals.

Neural Computation and the Computational Theory of Cognition

ERIC Educational Resources Information Center

Piccinini, Gualtiero; Bahar, Sonya

2013-01-01

We begin by distinguishing computationalism from a number of other theses that are sometimes conflated with it. We also distinguish between several important kinds of computation: computation in a generic sense, digital computation, and analog computation. Then, we defend a weak version of computationalism--neural processes are computations in the…

Analog "neuronal" networks in early vision.

PubMed Central

Koch, C; Marroquin, J; Yuille, A

1986-01-01

Many problems in early vision can be formulated in terms of minimizing a cost function. Examples are shape from shading, edge detection, motion analysis, structure from motion, and surface interpolation. As shown by Poggio and Koch [Poggio, T. & Koch, C. (1985) Proc. R. Soc. London, Ser. B 226, 303-323], quadratic variational problems, an important subset of early vision tasks, can be "solved" by linear, analog electrical, or chemical networks. However, in the presence of discontinuities, the cost function is nonquadratic, raising the question of designing efficient algorithms for computing the optimal solution. Recently, Hopfield and Tank [Hopfield, J. J. & Tank, D. W. (1985) Biol. Cybern. 52, 141-152] have shown that networks of nonlinear analog "neurons" can be effective in computing the solution of optimization problems. We show how these networks can be generalized to solve the nonconvex energy functionals of early vision. We illustrate this approach by implementing a specific analog network, solving the problem of reconstructing a smooth surface from sparse data while preserving its discontinuities. These results suggest a novel computational strategy for solving early vision problems in both biological and real-time artificial vision systems. PMID:3459172

A Short History of the Computer.

ERIC Educational Resources Information Center

Leon, George

1984-01-01

Briefly traces the development of computers from the abacus, John Napier's logarithms, the first computer/calculator (known as the Differential Engine), the first computer programming via steel punched cards, the electrical analog computer, electronic digital computer, and the transistor to the microchip of today's computers. (MBR)

Illumination-based synchronization of high-speed vision sensors.

PubMed

Hou, Lei; Kagami, Shingo; Hashimoto, Koichi

2010-01-01

To acquire images of dynamic scenes from multiple points of view simultaneously, the acquisition time of vision sensors should be synchronized. This paper describes an illumination-based synchronization method derived from the phase-locked loop (PLL) algorithm. Incident light to a vision sensor from an intensity-modulated illumination source serves as the reference signal for synchronization. Analog and digital computation within the vision sensor forms a PLL to regulate the output signal, which corresponds to the vision frame timing, to be synchronized with the reference. Simulated and experimental results show that a 1,000 Hz frame rate vision sensor was successfully synchronized with 32 μs jitters.

1989 IEEE Aerospace Applications Conference, Breckenridge, CO, Feb. 12-17, 1989, Conference Digest

NASA Astrophysics Data System (ADS)

Recent advances in electronic devices for aerospace applications are discussed in reviews and reports. Topics addressed include large-aperture mm-wave antennas, a cross-array radiometer for spacecraft applications, a technique for computing the propagation characteristics of optical fibers, an analog light-wave system for improving microwave-telemetry data communication, and a ground demonstration of an orbital-debris radar. Consideration is given to a verifiable autonomous satellite control system, Inmarsat second-generation satellites for mobile communication, automated tools for data-base design and criteria for their selection, and a desk-top simulation work station based on the DSP96002 microprocessor chip.

The Fermiac or Fermi's Trolley

NASA Astrophysics Data System (ADS)

Coccetti, F.

2016-03-01

The Fermiac, known also as Fermi's trolley or Monte Carlo trolley, is an analog computer used to determine the change in time of the neutron population in a nuclear device, via the Monte Carlo method. It was invented by Enrico Fermi and constructed by Percy King at Los Alamos in 1947, and used for about two years. A replica of the Fermiac was built at INFN mechanical workshops of Bologna in 2015, on behalf of the Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi", thanks to the original drawings made available by Los Alamos National Laboratory (LANL). This reproduction of the Fermiac was put in use, and a simulation was developed.

The NASA-AMES Research Center Stratospheric Aerosol Model. 1. Physical Processes and Computational Analogs

NASA Technical Reports Server (NTRS)

Turco, R. P.; Hamill, P.; Toon, O. B.; Whitten, R. C.; Kiang, C. S.

1979-01-01

A time-dependent one-dimensional model of the stratospheric sulfate aerosol layer is presented. In constructing the model, a wide range of basic physical and chemical processes are incorporated in order to avoid predetermining or biasing the model predictions. The simulation, which extends from the surface to an altitude of 58 km, includes the troposphere as a source of gases and condensation nuclei and as a sink for aerosol droplets. The size distribution of aerosol particles is resolved into 25 categories with particle radii increasing geometrically from 0.01 to 2.56 microns such that particle volume doubles between categories.

Instrumentation for Verification of Bomb Damage Repair Computer Code.

DTIC Science & Technology

1981-09-01

record the data, a conventional 14-track FM analog tape recorder was retained. The unknown factors of signal duration, test duration, and signal ...Kirtland Air Force Base computer centers for more detailed analyses. In addition to the analog recorder, signal conditioning equipment and amplifiers were...necessary to allow high quality data to be recorded. An Interrange Instrumentation Group (IRIG) code generator/reader placed a coded signal on the tape

A Computational Model Predicting Disruption of Blood Vessel Development

PubMed Central

Kleinstreuer, Nicole; Dix, David; Rountree, Michael; Baker, Nancy; Sipes, Nisha; Reif, David; Spencer, Richard; Knudsen, Thomas

2013-01-01

Vascular development is a complex process regulated by dynamic biological networks that vary in topology and state across different tissues and developmental stages. Signals regulating de novo blood vessel formation (vasculogenesis) and remodeling (angiogenesis) come from a variety of biological pathways linked to endothelial cell (EC) behavior, extracellular matrix (ECM) remodeling and the local generation of chemokines and growth factors. Simulating these interactions at a systems level requires sufficient biological detail about the relevant molecular pathways and associated cellular behaviors, and tractable computational models that offset mathematical and biological complexity. Here, we describe a novel multicellular agent-based model of vasculogenesis using the CompuCell3D (http://www.compucell3d.org/) modeling environment supplemented with semi-automatic knowledgebase creation. The model incorporates vascular endothelial growth factor signals, pro- and anti-angiogenic inflammatory chemokine signals, and the plasminogen activating system of enzymes and proteases linked to ECM interactions, to simulate nascent EC organization, growth and remodeling. The model was shown to recapitulate stereotypical capillary plexus formation and structural emergence of non-coded cellular behaviors, such as a heterologous bridging phenomenon linking endothelial tip cells together during formation of polygonal endothelial cords. Molecular targets in the computational model were mapped to signatures of vascular disruption derived from in vitro chemical profiling using the EPA's ToxCast high-throughput screening (HTS) dataset. Simulating the HTS data with the cell-agent based model of vascular development predicted adverse effects of a reference anti-angiogenic thalidomide analog, 5HPP-33, on in vitro angiogenesis with respect to both concentration-response and morphological consequences. These findings support the utility of cell agent-based models for simulating a morphogenetic series of events and for the first time demonstrate the applicability of these models for predictive toxicology. PMID:23592958

LibKiSAO: a Java library for Querying KiSAO.

PubMed

Zhukova, Anna; Adams, Richard; Laibe, Camille; Le Novère, Nicolas

2012-09-24

The Kinetic Simulation Algorithm Ontology (KiSAO) supplies information about existing algorithms available for the simulation of Systems Biology models, their characteristics, parameters and inter-relationships. KiSAO enables the unambiguous identification of algorithms from simulation descriptions. Information about analogous methods having similar characteristics and about algorithm parameters incorporated into KiSAO is desirable for simulation tools. To retrieve this information programmatically an application programming interface (API) for KiSAO is needed. We developed libKiSAO, a Java library to enable querying of the KiSA Ontology. It implements methods to retrieve information about simulation algorithms stored in KiSAO, their characteristics and parameters, and methods to query the algorithm hierarchy and search for similar algorithms providing comparable results for the same simulation set-up. Using libKiSAO, simulation tools can make logical inferences based on this knowledge and choose the most appropriate algorithm to perform a simulation. LibKiSAO also enables simulation tools to handle a wider range of simulation descriptions by determining which of the available methods are similar and can be used instead of the one indicated in the simulation description if that one is not implemented. LibKiSAO enables Java applications to easily access information about simulation algorithms, their characteristics and parameters stored in the OWL-encoded Kinetic Simulation Algorithm Ontology. LibKiSAO can be used by simulation description editors and simulation tools to improve reproducibility of computational simulation tasks and facilitate model re-use.

Processing-optimised imaging of analog geological models by electrical capacitance tomography

NASA Astrophysics Data System (ADS)

Ortiz Alemán, C.; Espíndola-Carmona, A.; Hernández-Gómez, J. J.; Orozco Del Castillo, MG

2017-06-01

In this work, the electrical capacitance tomography (ECT) technique is applied in monitoring internal deformation of geological analog models, which are used to study structural deformation mechanisms, in particular for simulating migration and emplacement of allochtonous salt bodies. A rectangular ECT sensor was used for internal visualization of analog geologic deformation. The monitoring of analog models consists in the reconstruction of permittivity images from the capacitance measurements obtained by introducing the model inside the ECT sensor. A simulated annealing (SA) algorithm is used as a reconstruction method, and is optimized by taking full advantage of some special features in a linearized version of this inverse approach. As a second part of this work our SA image reconstruction algorithm is applied to synthetic models, where its performance is evaluated in comparison to other commonly used algorithms such as linear back-projection and iterative Landweber methods. Finally, the SA method is applied to visualise two simple geological analog models. Encouraging results were obtained in terms of the quality of the reconstructed images, as interfaces corresponding to main geological units in the analog model were clearly distinguishable in them. We found reliable results quite useful for real time non-invasive monitoring of internal deformation of analog geological models.

Generalized concurrence in boson sampling.

PubMed

Chin, Seungbeom; Huh, Joonsuk

2018-04-17

A fundamental question in linear optical quantum computing is to understand the origin of the quantum supremacy in the physical system. It is found that the multimode linear optical transition amplitudes are calculated through the permanents of transition operator matrices, which is a hard problem for classical simulations (boson sampling problem). We can understand this problem by considering a quantum measure that directly determines the runtime for computing the transition amplitudes. In this paper, we suggest a quantum measure named "Fock state concurrence sum" C S , which is the summation over all the members of "the generalized Fock state concurrence" (a measure analogous to the generalized concurrences of entanglement and coherence). By introducing generalized algorithms for computing the transition amplitudes of the Fock state boson sampling with an arbitrary number of photons per mode, we show that the minimal classical runtime for all the known algorithms directly depends on C S . Therefore, we can state that the Fock state concurrence sum C S behaves as a collective measure that controls the computational complexity of Fock state BS. We expect that our observation on the role of the Fock state concurrence in the generalized algorithm for permanents would provide a unified viewpoint to interpret the quantum computing power of linear optics.

Biotoxicity of Mars soils: 1. Dry deposition of analog soils on microbial colonies and survival under Martian conditions

NASA Astrophysics Data System (ADS)

Schuerger, Andrew C.; Golden, D. C.; Ming, Doug W.

2012-11-01

Six Mars analog soils were created to simulate a range of potentially biotoxic geochemistries relevant to the survival of terrestrial microorganisms on Mars, and included basalt-only (non-toxic control), salt, acidic, alkaline, aeolian, and perchlorate rich geochemistries. Experiments were designed to simulate the dry-deposition of Mars soils onto spacecraft surfaces during an active descent landing scenario with propellant engines. Six eubacteria were initially tested for tolerance to desiccation, and the spore-former Bacillus subtilis HA101 and non-spore former Enterococcus faecalis ATCC 29212 were identified to be strongly resistant (HA101) and moderately resistant (29212) to desiccation at 24 °C. Furthermore, tests with B. subtilis and E. faecalis demonstrated that at least 1 mm of Mars analog soil was required to fully attenuate the biocidal effects of a simulated Mars-normal equatorial UV flux. Biotoxicity experiments were conducted under simulated Martian conditions of 6.9 mbar, -10 °C, CO2-enriched anoxic atmosphere, and a simulated equatorial solar spectrum (200-1100 nm) with an optical depth of 0.1. For B. subtilis, the six analog soils were found, in general, to be of low biotoxicity with only the high salt and acidic soils exhibiting the capacity to inactivate a moderate number of spores (<1 log reductions) exposed 7 days to the soils under simulated Martian conditions. In contrast, the overall response of E. faecalis to the analog soils was more dramatic with between two and three orders of magnitude reductions in viable cells for most soils, and between six and seven orders of magnitude reductions observed for the high-salt soil. Results suggest that Mars soils are likely not to be overtly biotoxic to terrestrial microorganisms, and suggest that the soil geochemistries on Mars will not preclude the habitability of the Martian surface.

Simulating Extraterrestrial Ices in the Laboratory

NASA Astrophysics Data System (ADS)

Berisford, D. F.; Carey, E. M.; Hand, K. P.; Choukroun, M.

2017-12-01

Several ongoing experiments at JPL attempt to simulate the ice environment for various regimes associated with icy moons. The Europa Penitent Ice Experiment (EPIX) simulates the surface environment of an icy moon, to investigate the physics of ice surface morphology growth. This experiment features half-meter-scale cryogenic ice samples, cryogenic radiative sink environment, vacuum conditions, and diurnal cycling solar simulation. The experiment also includes several smaller fixed-geometry vacuum chambers for ice simulation at Earth-like and intermediate temperature and vacuum conditions for development of surface morphology growth scaling relations. Additionally, an ice cutting facility built on a similar platform provides qualitative data on the mechanical behavior of cryogenic ice with impurities under vacuum, and allows testing of ice cutting/sampling tools relevant for landing spacecraft. A larger cutting facility is under construction at JPL, which will provide more quantitative data and allow full-scale sampling tool tests. Another facility, the JPL Ice Physics Laboratory, features icy analog simulant preparation abilities that range icy solar system objects such as Mars, Ceres and the icy satellites of Saturn and Jupiter. In addition, the Ice Physics Lab has unique facilities for Icy Analog Tidal Simulation and Rheological Studies of Cryogenic Icy Slurries, as well as equipment to perform thermal and mechanical properties testing on icy analog materials and their response to sinusoidal tidal stresses.

Hybrid computer technique yields random signal probability distributions

NASA Technical Reports Server (NTRS)

Cameron, W. D.

1965-01-01

Hybrid computer determines the probability distributions of instantaneous and peak amplitudes of random signals. This combined digital and analog computer system reduces the errors and delays of manual data analysis.

Analog simulation of a hybrid gasoline-electric vehicle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilmore, D.B.

1982-03-01

Hybrid vehicles using both internal combustion engines and electric motors represent one way to reduce fuel consumption. Our demonstration project envisioned more than halving the fuel consumption of a passenger vehicle by reducing greatly the capacity of its engine and adding regenerative braking and an all-electric range. We also envisaged maintaining the same performance as current passenger vehicles. A 0-6 000 rpm gasoline-driven internal combustion engine, two 0-7 800 rpm electric motors, a 0-7 800 rpm flywheel, and lead-acid batteries are the major components assembled using a mechnical epicyclic gear box. An EAI 681 analog computer allowed us to examinemore » quickly the effects of engine capacity, flywheel size, battery voltage, gear ratios, and mode of operation. An external potentiometer control on the computer allowed the operator to drive the vehicle through any acceleration cycle on level ground. We have shown that a 1.3 litre gasoline engine, two 13 kW separately excited direct current electric motors, a 38 kg flywheel, and a 48-volt battery pack will provide the same maximum performance as a conventional 4.1 litre internal combustion engine with automatic transmission at vehicle speeds below 60 km/h, and lower but satisfactory highway performance up to a top speed of 130 km/h. The transmission has undergone laboratory tests; it is to be road-tested in the first half of 1982.« less

The Effects of Longitudinal Control-System Dynamics on Pilot Opinion and Response Characteristics as Determined from Flight Tests and from Ground Simulator Studies

NASA Technical Reports Server (NTRS)

Sadoff, Melvin

1958-01-01

The results of a fixed-base simulator study of the effects of variable longitudinal control-system dynamics on pilot opinion are presented and compared with flight-test data. The control-system variables considered in this investigation included stick force per g, time constant, and dead-band, or stabilizer breakout force. In general, the fairly good correlation between flight and simulator results for two pilots demonstrates the validity of fixed-base simulator studies which are designed to complement and supplement flight studies and serve as a guide in control-system preliminary design. However, in the investigation of certain problem areas (e.g., sensitive control-system configurations associated with pilot- induced oscillations in flight), fixed-base simulator results did not predict the occurrence of an instability, although the pilots noted the system was extremely sensitive and unsatisfactory. If it is desired to predict pilot-induced-oscillation tendencies, tests in moving-base simulators may be required. It was found possible to represent the human pilot by a linear pilot analog for the tracking task assumed in the present study. The criterion used to adjust the pilot analog was the root-mean-square tracking error of one of the human pilots on the fixed-base simulator. Matching the tracking error of the pilot analog to that of the human pilot gave an approximation to the variation of human-pilot behavior over a range of control-system dynamics. Results of the pilot-analog study indicated that both for optimized control-system dynamics (for poor airplane dynamics) and for a region of good airplane dynamics, the pilot response characteristics are approximately the same.

Floquet engineering of Haldane Chern insulators and chiral bosonic phase transitions

NASA Astrophysics Data System (ADS)

Plekhanov, Kirill; Roux, Guillaume; Le Hur, Karyn

2017-01-01

The realization of synthetic gauge fields has attracted a lot of attention recently in relation to periodically driven systems and the Floquet theory. In ultracold atom systems in optical lattices and photonic networks, this allows one to simulate exotic phases of matter such as quantum Hall phases, anomalous quantum Hall phases, and analogs of topological insulators. In this paper, we apply the Floquet theory to engineer anisotropic Haldane models on the honeycomb lattice and two-leg ladder systems. We show that these anisotropic Haldane models still possess a topologically nontrivial band structure associated with chiral edge modes. Focusing on (interacting) boson systems in s -wave bands of the lattice, we show how to engineer through the Floquet theory, a quantum phase transition (QPT) between a uniform superfluid and a Bose-Einstein condensate analog of Fulde-Ferrell-Larkin-Ovchinnikov states, where bosons condense at nonzero wave vectors. We perform a Ginzburg-Landau analysis of the QPT on the graphene lattice, and compute observables such as chiral currents and the momentum distribution. The results are supported by exact diagonalization calculations and compared with those of the isotropic situation. The validity of high-frequency expansion in the Floquet theory is also tested using time-dependent simulations for various parameters of the model. Last, we show that the anisotropic choice for the effective vector potential allows a bosonization approach in equivalent ladder (strip) geometries.

Estimating the Error of an Analog Quantum Simulator by Additional Measurements

NASA Astrophysics Data System (ADS)

Schwenk, Iris; Zanker, Sebastian; Reiner, Jan-Michael; Leppäkangas, Juha; Marthaler, Michael

2017-12-01

We study an analog quantum simulator coupled to a reservoir with a known spectral density. The reservoir perturbs the quantum simulation by causing decoherence. The simulator is used to measure an operator average, which cannot be calculated using any classical means. Since we cannot predict the result, it is difficult to estimate the effect of the environment. Especially, it is difficult to resolve whether the perturbation is small or if the actual result of the simulation is in fact very different from the ideal system we intend to study. Here, we show that in specific systems a measurement of additional correlators can be used to verify the reliability of the quantum simulation. The procedure only requires additional measurements on the quantum simulator itself. We demonstrate the method theoretically in the case of a single spin connected to a bosonic environment.

Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis

PubMed Central

Kan, Zhong-Yuan; Walters, Benjamin T.; Mayne, Leland; Englander, S. Walter

2013-01-01

Hydrogen exchange technology provides a uniquely powerful instrument for measuring protein structural and biophysical properties, quantitatively and in a nonperturbing way, and determining how these properties are implemented to produce protein function. A developing hydrogen exchange–mass spectrometry method (HX MS) is able to analyze large biologically important protein systems while requiring only minuscule amounts of experimental material. The major remaining deficiency of the HX MS method is the inability to deconvolve HX results to individual amino acid residue resolution. To pursue this goal we used an iterative optimization program (HDsite) that integrates recent progress in multiple peptide acquisition together with previously unexamined isotopic envelope-shape information and a site-resolved back-exchange correction. To test this approach, residue-resolved HX rates computed from HX MS data were compared with extensive HX NMR measurements, and analogous comparisons were made in simulation trials. These tests found excellent agreement and revealed the important computational determinants. PMID:24019478

Time Domain Estimation of Arterial Parameters using the Windkessel Model and the Monte Carlo Method

NASA Astrophysics Data System (ADS)

Gostuski, Vladimir; Pastore, Ignacio; Rodriguez Palacios, Gaspar; Vaca Diez, Gustavo; Moscoso-Vasquez, H. Marcela; Risk, Marcelo

2016-04-01

Numerous parameter estimation techniques exist for characterizing the arterial system using electrical circuit analogs. However, they are often limited by their requirements and usually high computational burdain. Therefore, a new method for estimating arterial parameters based on Monte Carlo simulation is proposed. A three element Windkessel model was used to represent the arterial system. The approach was to reduce the error between the calculated and physiological aortic pressure by randomly generating arterial parameter values, while keeping constant the arterial resistance. This last value was obtained for each subject using the arterial flow, and was a necessary consideration in order to obtain a unique set of values for the arterial compliance and peripheral resistance. The estimation technique was applied to in vivo data containing steady beats in mongrel dogs, and it reliably estimated Windkessel arterial parameters. Further, this method appears to be computationally efficient for on-line time-domain estimation of these parameters.

Periodic control of the individual-blade-control helicopter rotor. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Mckillip, R. M., Jr.

1984-01-01

Results of an investigation into methods of controller design for an individual helicopter rotor blade in the high forward-flight speed regime are described. This operating condition poses a unique control problem in that the perturbation equations of motion are linear with coefficients that vary periodically with time. The design of a control law was based on extensions to modern multivariate synthesis techniques and incorporated a novel approach to the reconstruction of the missing system state variables. The controller was tested on both an electronic analog computer simulation of the out-of-plane flapping dynamics, and on a four foot diameter single-bladed model helicopter rotor in the M.I.T. 5x7 subsonic wind tunnel at high levels of advance ratio. It is shown that modal control using the IBC concept is possible over a large range of advance ratios with only a modest amount of computational power required.

Computational investigation of the conformational profile of the four stereomers of Ac-L-Pro-c3Phe-NHMe (c3Phe= 2,3-methanophenylalanine).

PubMed

Rodriguez, Alejandro; Canto, Josep; Corcho, Francesc J; Perez, Juan J

2009-01-01

The present report regards a computational study aimed at assessing the conformational profile of the four stereoisomers of the peptide Ace-Pro-c3Phe-NMe, previously reported to exhibit beta-turn structures in dichloromethane with different type I/type II beta-turn profiles. Molecular systems were represented at the molecular mechanics level using the parm96 parameterization of the AMBER force field. Calculations were carried out in dichloromethane using an implicit solvent approach. Characterization of the conformational features of the peptide analogs was carried out using simulated annealing (SA), molecular dynamics (MD) and replica exchange molecular dynamics (REMD). Present results show that MD calculations do not provide a reasonable sampling after 300 ns. In contrast, both SA and REMD provide similar results and agree well with experimental observations. Copyright 2009 Wiley Periodicals, Inc.

SIMPL Systems, or: Can We Design Cryptographic Hardware without Secret Key Information?

NASA Astrophysics Data System (ADS)

Rührmair, Ulrich

This paper discusses a new cryptographic primitive termed SIMPL system. Roughly speaking, a SIMPL system is a special type of Physical Unclonable Function (PUF) which possesses a binary description that allows its (slow) public simulation and prediction. Besides this public key like functionality, SIMPL systems have another advantage: No secret information is, or needs to be, contained in SIMPL systems in order to enable cryptographic protocols - neither in the form of a standard binary key, nor as secret information hidden in random, analog features, as it is the case for PUFs. The cryptographic security of SIMPLs instead rests on (i) a physical assumption on their unclonability, and (ii) a computational assumption regarding the complexity of simulating their output. This novel property makes SIMPL systems potentially immune against many known hardware and software attacks, including malware, side channel, invasive, or modeling attacks.

GPU-based simulations of fracture in idealized brick and mortar composites

NASA Astrophysics Data System (ADS)

William Pro, J.; Kwei Lim, Rone; Petzold, Linda R.; Utz, Marcel; Begley, Matthew R.

2015-07-01

Stiff ceramic platelets (or bricks) that are aligned and bonded to a second ductile phase with low volume fraction (mortar) are a promising pathway to produce stiff, high-toughness composites. For certain ranges of constituent properties, including those of some synthetic analogs to nacre, one can demonstrate that the deformation is dominated by relative brick motions. This paper describes simulations of fracture that explicitly track the motions of individual rigid bricks in an idealized microstructure; cohesive tractions acting between the bricks introduce elastic, plastic and rupture behaviors. Results are presented for the stresses and damage near macroscopic cracks with different brick orientations relative to the loading orientation. The anisotropic macroscopic initiation toughness is computed for small-scale yielding conditions and is shown to be independent of specimen geometry and loading configuration. The results are shown to be in agreement with previously published experiments on synthetic nacre.

Gas-injection-start and shutdown characteristics of a 2-kilowatt to 15-kilowatt Brayton power system

NASA Technical Reports Server (NTRS)

Cantoni, D. A.

1972-01-01

Two methods of starting the Brayton power system have been considered: (1) using the alternator as a motor to spin the Brayton rotating unit (BRU), and (2) spinning the BRU by forced gas injection. The first method requires the use of an auxiliary electrical power source. An alternating voltage is applied to the terminals of the alternator to drive it as an induction motor. Only gas-injection starts are discussed in this report. The gas-injection starting method requires high-pressure gas storage and valves to route the gas flow to provide correct BRU rotation. An analog computer simulation was used to size hardware and to determine safe start and shutdown procedures. The simulation was also used to define the range of conditions for successful startups. Experimental data were also obtained under various test conditions. These data verify the validity of the start and shutdown procedures.

Configurational entropy measurements in extremely supercooled liquids that break the glass ceiling.

PubMed

Berthier, Ludovic; Charbonneau, Patrick; Coslovich, Daniele; Ninarello, Andrea; Ozawa, Misaki; Yaida, Sho

2017-10-24

Liquids relax extremely slowly on approaching the glass state. One explanation is that an entropy crisis, because of the rarefaction of available states, makes it increasingly arduous to reach equilibrium in that regime. Validating this scenario is challenging, because experiments offer limited resolution, while numerical studies lag more than eight orders of magnitude behind experimentally relevant timescales. In this work, we not only close the colossal gap between experiments and simulations but manage to create in silico configurations that have no experimental analog yet. Deploying a range of computational tools, we obtain four estimates of their configurational entropy. These measurements consistently confirm that the steep entropy decrease observed in experiments is also found in simulations, even beyond the experimental glass transition. Our numerical results thus extend the observational window into the physics of glasses and reinforce the relevance of an entropy crisis for understanding their formation. Published under the PNAS license.

Breaking the glass ceiling: Configurational entropy measurements in extremely supercooled liquids

NASA Astrophysics Data System (ADS)

Berthier, Ludovic

Liquids relax extremely slowly on approaching the glass state. One explanation is that an entropy crisis, due to the rarefaction of available states, makes it increasingly arduous to reach equilibrium in that regime. Validating this scenario is challenging, because experiments offer limited resolution, while numerical studies lag more than eight orders of magnitude behind experimentally-relevant timescales. In this work we not only close the colossal gap between experiments and simulations but manage to create in-silico configurations that have no experimental analog yet. Deploying a range of computational tools, we obtain four independent estimates of their configurational entropy. These measurements consistently indicate that the steep entropy decrease observed in experiments is found in simulations even beyond the experimental glass transition. Our numerical results thus open a new observational window into the physics of glasses and reinforce the relevance of an entropy crisis for understanding their formation.

Channel Training for Analog FDD Repeaters: Optimal Estimators and Cramér-Rao Bounds

NASA Astrophysics Data System (ADS)

Wesemann, Stefan; Marzetta, Thomas L.

2017-12-01

For frequency division duplex channels, a simple pilot loop-back procedure has been proposed that allows the estimation of the UL & DL channels at an antenna array without relying on any digital signal processing at the terminal side. For this scheme, we derive the maximum likelihood (ML) estimators for the UL & DL channel subspaces, formulate the corresponding Cram\\'er-Rao bounds and show the asymptotic efficiency of both (SVD-based) estimators by means of Monte Carlo simulations. In addition, we illustrate how to compute the underlying (rank-1) SVD with quadratic time complexity by employing the power iteration method. To enable power control for the data transmission, knowledge of the channel gains is needed. Assuming that the UL & DL channels have on average the same gain, we formulate the ML estimator for the channel norm, and illustrate its robustness against strong noise by means of simulations.

Configurational entropy measurements in extremely supercooled liquids that break the glass ceiling

PubMed Central

Berthier, Ludovic; Charbonneau, Patrick; Coslovich, Daniele; Ninarello, Andrea; Ozawa, Misaki

2017-01-01

Liquids relax extremely slowly on approaching the glass state. One explanation is that an entropy crisis, because of the rarefaction of available states, makes it increasingly arduous to reach equilibrium in that regime. Validating this scenario is challenging, because experiments offer limited resolution, while numerical studies lag more than eight orders of magnitude behind experimentally relevant timescales. In this work, we not only close the colossal gap between experiments and simulations but manage to create in silico configurations that have no experimental analog yet. Deploying a range of computational tools, we obtain four estimates of their configurational entropy. These measurements consistently confirm that the steep entropy decrease observed in experiments is also found in simulations, even beyond the experimental glass transition. Our numerical results thus extend the observational window into the physics of glasses and reinforce the relevance of an entropy crisis for understanding their formation. PMID:29073056

Configurational entropy measurements in extremely supercooled liquids that break the glass ceiling

NASA Astrophysics Data System (ADS)

Berthier, Ludovic; Charbonneau, Patrick; Coslovich, Daniele; Ninarello, Andrea; Ozawa, Misaki; Yaida, Sho

2017-10-01

Liquids relax extremely slowly on approaching the glass state. One explanation is that an entropy crisis, because of the rarefaction of available states, makes it increasingly arduous to reach equilibrium in that regime. Validating this scenario is challenging, because experiments offer limited resolution, while numerical studies lag more than eight orders of magnitude behind experimentally relevant timescales. In this work, we not only close the colossal gap between experiments and simulations but manage to create in silico configurations that have no experimental analog yet. Deploying a range of computational tools, we obtain four estimates of their configurational entropy. These measurements consistently confirm that the steep entropy decrease observed in experiments is also found in simulations, even beyond the experimental glass transition. Our numerical results thus extend the observational window into the physics of glasses and reinforce the relevance of an entropy crisis for understanding their formation.

Numerical Simulation of Liquid Jet Atomization Including Turbulence Effects

NASA Technical Reports Server (NTRS)

Trinh, Huu P.; Chen, C. P.; Balasubramanyam, M. S.

2005-01-01

This paper describes numerical implementation of a newly developed hybrid model, T-blob/T-TAB, into an existing computational fluid dynamics (CFD) program for primary and secondary breakup simulation of liquid jet atomization. This model extend two widely used models, the Kelvin-Helmholtz (KH) instability of Reitz (blob model) and the Taylor-Analogy-Breakup (TAB) secondary droplet breakup by O'Rourke and Amsden to include turbulence effects. In the primary breakup model, the level of the turbulence effect on the liquid breakup depends on the characteristic scales and the initial flow conditions. For the secondary breakup, an additional turbulence force acted on parent drops is modeled and integrated into the TAB governing equation. Several assessment studies are presented and the results indicate that the existing KH and TAB models tend to under-predict the product drop size and spray angle, while the current model provides superior results when compared with the measured data.

Two-dimensional dynamic stall as simulated in a varying freestream

NASA Technical Reports Server (NTRS)

Pierce, G. A.; Kunz, D. L.; Malone, J. B.

1978-01-01

A low speed wind tunnel equipped with a axial gust generator to simulate the aerodynamic environment of a helicopter rotor was used to study the dynamic stall of a pitching blade in an effort to ascertain to what extent harmonic velocity perturbations in the freestream affect dynamic stall. The aerodynamic moment on a two dimensional, pitching blade model in both constant and pulsating airstream was measured. An operational analog computer was used to perform on-line data reduction and plots of moment versus angle of attack and work done by the moment were obtained. The data taken in the varying freestream were then compared to constant freestream data and to the results of two analytical methods. These comparisons show that the velocity perturbations have a significant effect on the pitching moment which can not be consistently predicted by the analytical methods, but had no drastic effect on the blade stability.

Project Introduction for SUBSEA: Systematic Underwater Biogeochemical Science and Exploration Analog

NASA Astrophysics Data System (ADS)

Nawotniak, S. E. K.; Lim, D. S. S.; German, C. R.; Shock, E. L.; Huber, J. A.; Breier, J. A.

2018-05-01

NASA SUBSEA studies low T, low P seamounts via integrated volcanology, geochemistry, and microbiology as an analog for Enceladus. Research done in telerobotic space exploration simulation. First cruise is Loihi in August 2018.

Computers in Electrical Engineering Education at Virginia Polytechnic Institute.

ERIC Educational Resources Information Center

Bennett, A. Wayne

1982-01-01

Discusses use of computers in Electrical Engineering (EE) at Virginia Polytechnic Institute. Topics include: departmental background, level of computing power using large scale systems, mini and microcomputers, use of digital logic trainers and analog/hybrid computers, comments on integrating computers into EE curricula, and computer use in…

Aqueous Alteration of Basaltic Glass Under a Simulated Mars Atmosphere

NASA Technical Reports Server (NTRS)

Bullock, M. A.; Moore, J. M.

2005-01-01

For the past several years we have been performing experiments designed to produce brines under Mars-simulated conditions. Previously, we had generated and analyzed Mars-analog brines by allowing a mixture of minerals derived from SNC mineralogy to soak in pure water under a synthetic current-Mars atmosphere and under a gas similar to the present Mars atmosphere but with added acidic gases. The latest version of these experiments incubates basaltic glass, obtained from recent Kilauea flows (Mother's Day flow in December 2002), in pure water under a present-day Mars analog atmosphere at 25 C. This abstract and our presentation will discuss the composition of these Mars-analog brines and implications for Mars surface chemistry.

Scalable Multiprocessor for High-Speed Computing in Space

NASA Technical Reports Server (NTRS)

Lux, James; Lang, Minh; Nishimoto, Kouji; Clark, Douglas; Stosic, Dorothy; Bachmann, Alex; Wilkinson, William; Steffke, Richard

2004-01-01

A report discusses the continuing development of a scalable multiprocessor computing system for hard real-time applications aboard a spacecraft. "Hard realtime applications" signifies applications, like real-time radar signal processing, in which the data to be processed are generated at "hundreds" of pulses per second, each pulse "requiring" millions of arithmetic operations. In these applications, the digital processors must be tightly integrated with analog instrumentation (e.g., radar equipment), and data input/output must be synchronized with analog instrumentation, controlled to within fractions of a microsecond. The scalable multiprocessor is a cluster of identical commercial-off-the-shelf generic DSP (digital-signal-processing) computers plus generic interface circuits, including analog-to-digital converters, all controlled by software. The processors are computers interconnected by high-speed serial links. Performance can be increased by adding hardware modules and correspondingly modifying the software. Work is distributed among the processors in a parallel or pipeline fashion by means of a flexible master/slave control and timing scheme. Each processor operates under its own local clock; synchronization is achieved by broadcasting master time signals to all the processors, which compute offsets between the master clock and their local clocks.

Harry Mergler with His Modified Differential Analyzer

NASA Image and Video Library

1951-06-21

Harry Mergler stands at the control board of a differential analyzer in the new Instrument Research Laboratory at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory. The differential analyzer was a multi-variable analog computation machine devised in 1931 by Massachusetts Institute of Technology researcher and future NACA Committee member Vannevar Bush. The mechanical device could solve computations up to the sixth order, but had to be rewired before each new computation. Mergler modified Bush’s differential analyzer in the late 1940s to calculate droplet trajectories for Lewis’ icing research program. In four days Mergler’s machine could calculate what previously required weeks. NACA Lewis built the Instrument Research Laboratory in 1950 and 1951 to house the large analog computer equipment. The two-story structure also provided offices for the Mechanical Computational Analysis, and Flow Physics sections of the Physics Division. The division had previously operated from the lab’s hangar because of its icing research and flight operations activities. Mergler joined the Instrument Research Section of the Physics Division in 1948 after earning an undergraduate degree in Physics from the Case Institute of Technology. Mergler’s focus was on the synthesis of analog computers with the machine tools used to create compressor and turbine blades for jet engines.

Simulation and optimization of a dc SQUID with finite capacitance

NASA Astrophysics Data System (ADS)

de Waal, V. J.; Schrijner, P.; Llurba, R.

1984-02-01

This paper deals with the calculations of the noise and the optimization of the energy resolution of a dc SQUID with finite junction capacitance. Up to now noise calculations of dc SQUIDs were performed using a model without parasitic capacitances across the Josephson junctions. As the capacitances limit the performance of the SQUID, for a good optimization one must take them into account. The model consists of two coupled nonlinear second-order differential equations. The equations are very suitable for simulation with an analog circuit. We implemented the model on a hybrid computer. The noise spectrum from the model is calculated with a fast Fourier transform. A calculation of the energy resolution for one set of parameters takes about 6 min of computer time. Detailed results of the optimization are given for products of inductance and temperature of LT=1.2 and 5 nH K. Within a range of β and β c between 1 and 2, which is optimum, the energy resolution is nearly independent of these variables. In this region the energy resolution is near the value calculated without parasitic capacitances. Results of the optimized energy resolution are given as a function of LT between 1.2 and 10 mH K.

Mixed Single/Double Precision in OpenIFS: A Detailed Study of Energy Savings, Scaling Effects, Architectural Effects, and Compilation Effects

NASA Astrophysics Data System (ADS)

Fagan, Mike; Dueben, Peter; Palem, Krishna; Carver, Glenn; Chantry, Matthew; Palmer, Tim; Schlacter, Jeremy

2017-04-01

It has been shown that a mixed precision approach that judiciously replaces double precision with single precision calculations can speed-up global simulations. In particular, a mixed precision variation of the Integrated Forecast System (IFS) of the European Centre for Medium-Range Weather Forecasts (ECMWF) showed virtually the same quality model results as the standard double precision version (Vana et al., Single precision in weather forecasting models: An evaluation with the IFS, Monthly Weather Review, in print). In this study, we perform detailed measurements of savings in computing time and energy using a mixed precision variation of the -OpenIFS- model. The mixed precision variation of OpenIFS is analogous to the IFS variation used in Vana et al. We (1) present results for energy measurements for simulations in single and double precision using Intel's RAPL technology, (2) conduct a -scaling- study to quantify the effects that increasing model resolution has on both energy dissipation and computing cycles, (3) analyze the differences between single core and multicore processing, and (4) compare the effects of different compiler technologies on the mixed precision OpenIFS code. In particular, we compare intel icc/ifort with gnu gcc/gfortran.

Atmospheric Turbulence Modeling for Aero Vehicles: Fractional Order Fits

NASA Technical Reports Server (NTRS)

Kopasakis, George

2015-01-01

Atmospheric turbulence models are necessary for the design of both inlet/engine and flight controls, as well as for studying coupling between the propulsion and the vehicle structural dynamics for supersonic vehicles. Models based on the Kolmogorov spectrum have been previously utilized to model atmospheric turbulence. In this paper, a more accurate model is developed in its representative fractional order form, typical of atmospheric disturbances. This is accomplished by first scaling the Kolmogorov spectral to convert them into finite energy von Karman forms and then by deriving an explicit fractional circuit-filter type analog for this model. This circuit model is utilized to develop a generalized formulation in frequency domain to approximate the fractional order with the products of first order transfer functions, which enables accurate time domain simulations. The objective of this work is as follows. Given the parameters describing the conditions of atmospheric disturbances, and utilizing the derived formulations, directly compute the transfer function poles and zeros describing these disturbances for acoustic velocity, temperature, pressure, and density. Time domain simulations of representative atmospheric turbulence can then be developed by utilizing these computed transfer functions together with the disturbance frequencies of interest.

Atmospheric Turbulence Modeling for Aero Vehicles: Fractional Order Fits

NASA Technical Reports Server (NTRS)

Kopasakis, George

2010-01-01

Atmospheric turbulence models are necessary for the design of both inlet/engine and flight controls, as well as for studying coupling between the propulsion and the vehicle structural dynamics for supersonic vehicles. Models based on the Kolmogorov spectrum have been previously utilized to model atmospheric turbulence. In this paper, a more accurate model is developed in its representative fractional order form, typical of atmospheric disturbances. This is accomplished by first scaling the Kolmogorov spectral to convert them into finite energy von Karman forms and then by deriving an explicit fractional circuit-filter type analog for this model. This circuit model is utilized to develop a generalized formulation in frequency domain to approximate the fractional order with the products of first order transfer functions, which enables accurate time domain simulations. The objective of this work is as follows. Given the parameters describing the conditions of atmospheric disturbances, and utilizing the derived formulations, directly compute the transfer function poles and zeros describing these disturbances for acoustic velocity, temperature, pressure, and density. Time domain simulations of representative atmospheric turbulence can then be developed by utilizing these computed transfer functions together with the disturbance frequencies of interest.

Computer simulation of the effect of dDAVP with saline loading on fluid balance after 24-hour head-down tilt

NASA Technical Reports Server (NTRS)

Srinivasan, R. S.; Simanonok, K. E.; Charles, J. B.

1994-01-01

Fluid loading (FL) before Shuttle reentry is a countermeasure currently in use by NASA to improve the orthostatic tolerance of astronauts during reentry and postflight. The fluid load consists of water and salt tablets equivalent to 32 oz (946 ml) of isotonic saline. However, the effectiveness of this countermeasure has been observed to decrease with the duration of spaceflight. The countermeasure's effectiveness may be improved by enhancing fluid retention using analogs of vasopressin such as lypressin (LVP) and desmopressin (dDAVP). In a computer simulation study reported previously, we attempted to assess the improvement in fluid retention obtained by the use of LVP administered before FL. The present study is concerned with the use of dDAVP. In a recent 24-hour, 6 degree head-down tilt (HDT) study involving seven men, dDAVP was found to improve orthostatic tolerance as assessed by both lower body negative pressure (LBNP) and stand tests. The treatment restored Luft's cumulative stress index (cumulative product of magnitude and duration of LBNP) to nearly pre-bedrest level. The heart rate was lower and stroke volume was marginally higher at the same LBNP levels with administration of dDAVP compared to placebo. Lower heart rates were also observed with dDAVP during stand test, despite the lower level of cardiovascular stress. These improvements were seen with only a small but significant increase in plasma volume of approximately 3 percent. This paper presents a computer simulation analysis of some of the results of this HDT study.

Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations for solvent-based carbon capture. Part 2: Chemical absorption across a wetted wall column: Original Research Article: Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Chao; Xu, Zhijie; Lai, Kevin

Part 1 of this paper presents a numerical model for non-reactive physical mass transfer across a wetted wall column (WWC). In Part 2, we improved the existing computational fluid dynamics (CFD) model to simulate chemical absorption occurring in a WWC as a bench-scale study of solvent-based carbon dioxide (CO2) capture. To generate data for WWC model validation, CO2 mass transfer across a monoethanolamine (MEA) solvent was first measured on a WWC experimental apparatus. The numerical model developed in this work can account for both chemical absorption and desorption of CO2 in MEA. In addition, the overall mass transfer coefficient predictedmore » using traditional/empirical correlations is conducted and compared with CFD prediction results for both steady and wavy falling films. A Bayesian statistical calibration algorithm is adopted to calibrate the reaction rate constants in chemical absorption/desorption of CO2 across a falling film of MEA. The posterior distributions of the two transport properties, i.e., Henry's constant and gas diffusivity in the non-reacting nitrous oxide (N2O)/MEA system obtained from Part 1 of this study, serves as priors for the calibration of CO2 reaction rate constants after using the N2O/CO2 analogy method. The calibrated model can be used to predict the CO2 mass transfer in a WWC for a wider range of operating conditions.« less

Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations for solvent-based carbon capture. Part 2: Chemical absorption across a wetted wall column: Original Research Article: Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations

DOE PAGES

Wang, Chao; Xu, Zhijie; Lai, Kevin; ...

2017-10-24

Part 1 of this paper presents a numerical model for non-reactive physical mass transfer across a wetted wall column (WWC). In Part 2, we improved the existing computational fluid dynamics (CFD) model to simulate chemical absorption occurring in a WWC as a bench-scale study of solvent-based carbon dioxide (CO2) capture. To generate data for WWC model validation, CO2 mass transfer across a monoethanolamine (MEA) solvent was first measured on a WWC experimental apparatus. The numerical model developed in this work can account for both chemical absorption and desorption of CO2 in MEA. In addition, the overall mass transfer coefficient predictedmore » using traditional/empirical correlations is conducted and compared with CFD prediction results for both steady and wavy falling films. A Bayesian statistical calibration algorithm is adopted to calibrate the reaction rate constants in chemical absorption/desorption of CO2 across a falling film of MEA. The posterior distributions of the two transport properties, i.e., Henry's constant and gas diffusivity in the non-reacting nitrous oxide (N2O)/MEA system obtained from Part 1 of this study, serves as priors for the calibration of CO2 reaction rate constants after using the N2O/CO2 analogy method. The calibrated model can be used to predict the CO2 mass transfer in a WWC for a wider range of operating conditions.« less

The Analog Revolution and Its On-Going Role in Modern Analytical Measurements.

PubMed

Enke, Christie G

2015-12-15

The electronic revolution in analytical instrumentation began when we first exceeded the two-digit resolution of panel meters and chart recorders and then took the first steps into automated control. It started with the first uses of operational amplifiers (op amps) in the analog domain 20 years before the digital computer entered the analytical lab. Their application greatly increased both accuracy and precision in chemical measurement and they provided an elegant means for the electronic control of experimental quantities. Later, laboratory and personal computers provided an unlimited readout resolution and enabled programmable control of instrument parameters as well as storage and computation of acquired data. However, digital computers did not replace the op amp's critical role of converting the analog sensor's output to a robust and accurate voltage. Rather it added a new role: converting that voltage into a number. These analog operations are generally the limiting portions of our computerized instrumentation systems. Operational amplifier performance in gain, input current and resistance, offset voltage, and rise time have improved by a remarkable 3-4 orders of magnitude since their first implementations. Each 10-fold improvement has opened the doors for the development of new techniques in all areas of chemical analysis. Along with some interesting history, the multiple roles op amps play in modern instrumentation are described along with a number of examples of new areas of analysis that have been enabled by their improvements.

Light scattering by planetary-regolith analog samples: computational results

NASA Astrophysics Data System (ADS)

Väisänen, Timo; Markkanen, Johannes; Hadamcik, Edith; Levasseur-Regourd, Anny-Chantal; Lasue, Jeremie; Blum, Jürgen; Penttilä, Antti; Muinonen, Karri

2017-04-01

We compute light scattering by a planetary-regolith analog surface. The corresponding experimental work is from Hadamcik et al. [1] with the PROGRA2-surf [2] device measuring the polarization of dust particles. The analog samples are low density (volume fraction 0.15 ± 0.03) agglomerates produced by random ballistic deposition of almost equisized silica spheres (refractive index n=1.5 and diameter 1.45 ± 0.06 µm). Computations are carried out with the recently developed codes entitled Radiative Transfer with Reciprocal Transactions (R2T2) and Radiative Transfer Coherent Backscattering with incoherent interactions (RT-CB-ic). Both codes incorporate the so-called incoherent treatment which enhances the applicability of the radiative transfer as shown by Muinonen et al. [3]. As a preliminary result, we have computed scattering from a large spherical medium with the RT-CB-ic using equal-sized particles with diameters of 1.45 microns. The preliminary results have shown that the qualitative characteristics are similar for the computed and measured intensity and polarization curves but that there are still deviations between the characteristics. We plan to remove the deviations by incorporating a size distribution of particles (1.45 ± 0.02 microns) and detailed information about the volume density profile within the analog surface. Acknowledgments: We acknowledge the ERC Advanced Grant no. 320773 entitled Scattering and Absorption of Electromagnetic Waves in Particulate Media (SAEMPL). Computational resources were provided by CSC - IT Centre for Science Ltd, Finland. References: [1] Hadamcik E. et al. (2007), JQSRT, 106, 74-89 [2] Levasseur-Regourd A.C. et al. (2015), Polarimetry of stars and planetary systems, CUP, 61-80 [3] Muinonen K. et al. (2016), extended abstract for EMTS.

Lightweight Filter Architecture for Energy Efficient Mobile Vehicle Localization Based on a Distributed Acoustic Sensor Network

PubMed Central

Kim, Keonwook

2013-01-01

The generic properties of an acoustic signal provide numerous benefits for localization by applying energy-based methods over a deployed wireless sensor network (WSN). However, the signal generated by a stationary target utilizes a significant amount of bandwidth and power in the system without providing further position information. For vehicle localization, this paper proposes a novel proximity velocity vector estimator (PVVE) node architecture in order to capture the energy from a moving vehicle and reject the signal from motionless automobiles around the WSN node. A cascade structure between analog envelope detector and digital exponential smoothing filter presents the velocity vector-sensitive output with low analog circuit and digital computation complexity. The optimal parameters in the exponential smoothing filter are obtained by analytical and mathematical methods for maximum variation over the vehicle speed. For stationary targets, the derived simulation based on the acoustic field parameters demonstrates that the system significantly reduces the communication requirements with low complexity and can be expected to extend the operation time considerably. PMID:23979482

Shock Wave Propagation in Functionally Graded Mineralized Tissue

NASA Astrophysics Data System (ADS)

Nelms, Matthew; Hodo, Wayne; Livi, Ken; Browning, Alyssa; Crawford, Bryan; Rajendran, A. M.

2017-06-01

In this investigation, the effects of shock wave propagation in bone-like biomineralized tissue was investigated. The Alligator gar (Atractosteus spatula) exoskeleton is comprised of many disparate scales that provide a biological analog for potential design of flexible protective material systems. The gar scale is identified as a two-phase, (1) hydroxyapatite mineral and (2) collagen protein, biological composite with two distinct layers where a stiff, ceramic-like ganoine overlays a soft, highly ductile ganoid bone. Previous experimentations has shown significant softening under compressive loading and an asymmetrical stress-strain response for analogous mineralized tissues. The structural features, porosity, and elastic modulus were determined from high-resolution scanning electron microscopy, 3D micro-tomography, and dynamic nanoindentation experiments to develop an idealized computational model for FE simulations. The numerical analysis employed Gurson's yield criterion to determine the influence of porosity and pressure on material strength. Functional gradation of elastic moduli and certain structural features, such as the sawtooth interface, are explicitly modeled to study the plate impact shock profile for a full 3-D analysis using ABAQUS finite element software.

Hidden Statistics Approach to Quantum Simulations

NASA Technical Reports Server (NTRS)

Zak, Michail

2010-01-01

Recent advances in quantum information theory have inspired an explosion of interest in new quantum algorithms for solving hard computational (quantum and non-quantum) problems. The basic principle of quantum computation is that the quantum properties can be used to represent structure data, and that quantum mechanisms can be devised and built to perform operations with this data. Three basic non-classical properties of quantum mechanics superposition, entanglement, and direct-product decomposability were main reasons for optimism about capabilities of quantum computers that promised simultaneous processing of large massifs of highly correlated data. Unfortunately, these advantages of quantum mechanics came with a high price. One major problem is keeping the components of the computer in a coherent state, as the slightest interaction with the external world would cause the system to decohere. That is why the hardware implementation of a quantum computer is still unsolved. The basic idea of this work is to create a new kind of dynamical system that would preserve the main three properties of quantum physics superposition, entanglement, and direct-product decomposability while allowing one to measure its state variables using classical methods. In other words, such a system would reinforce the advantages and minimize limitations of both quantum and classical aspects. Based upon a concept of hidden statistics, a new kind of dynamical system for simulation of Schroedinger equation is proposed. The system represents a modified Madelung version of Schroedinger equation. It preserves superposition, entanglement, and direct-product decomposability while allowing one to measure its state variables using classical methods. Such an optimal combination of characteristics is a perfect match for simulating quantum systems. The model includes a transitional component of quantum potential (that has been overlooked in previous treatment of the Madelung equation). The role of the transitional potential is to provide a jump from a deterministic state to a random state with prescribed probability density. This jump is triggered by blowup instability due to violation of Lipschitz condition generated by the quantum potential. As a result, the dynamics attains quantum properties on a classical scale. The model can be implemented physically as an analog VLSI-based (very-large-scale integration-based) computer, or numerically on a digital computer. This work opens a way of developing fundamentally new algorithms for quantum simulations of exponentially complex problems that expand NASA capabilities in conducting space activities. It has been illustrated that the complexity of simulations of particle interaction can be reduced from an exponential one to a polynomial one.

Analog Computer Solution of the Electrodiffusion Equation for a Simple Membrane

ERIC Educational Resources Information Center

Onega, Ronald J.

1972-01-01

An analog solution was obtained for the Nenst-Planck and Poisson equations which describe the ion concentration across a simple membrane held at a potential difference. The electric field variation within the membrane was also determined. (Author/TS)

Joint Transmit and Receive Filter Optimization for Sub-Nyquist Delay-Doppler Estimation

NASA Astrophysics Data System (ADS)

Lenz, Andreas; Stein, Manuel S.; Swindlehurst, A. Lee

2018-05-01

In this article, a framework is presented for the joint optimization of the analog transmit and receive filter with respect to a parameter estimation problem. At the receiver, conventional signal processing systems restrict the two-sided bandwidth of the analog pre-filter $B$ to the rate of the analog-to-digital converter $f_s$ to comply with the well-known Nyquist-Shannon sampling theorem. In contrast, here we consider a transceiver that by design violates the common paradigm $B\\leq f_s$. To this end, at the receiver, we allow for a higher pre-filter bandwidth $B>f_s$ and study the achievable parameter estimation accuracy under a fixed sampling rate when the transmit and receive filter are jointly optimized with respect to the Bayesian Cram\\'{e}r-Rao lower bound. For the case of delay-Doppler estimation, we propose to approximate the required Fisher information matrix and solve the transceiver design problem by an alternating optimization algorithm. The presented approach allows us to explore the Pareto-optimal region spanned by transmit and receive filters which are favorable under a weighted mean squared error criterion. We also discuss the computational complexity of the obtained transceiver design by visualizing the resulting ambiguity function. Finally, we verify the performance of the optimized designs by Monte-Carlo simulations of a likelihood-based estimator.

Proposal for an All-Spin Artificial Neural Network: Emulating Neural and Synaptic Functionalities Through Domain Wall Motion in Ferromagnets.

PubMed

Sengupta, Abhronil; Shim, Yong; Roy, Kaushik

2016-12-01

Non-Boolean computing based on emerging post-CMOS technologies can potentially pave the way for low-power neural computing platforms. However, existing work on such emerging neuromorphic architectures have either focused on solely mimicking the neuron, or the synapse functionality. While memristive devices have been proposed to emulate biological synapses, spintronic devices have proved to be efficient at performing the thresholding operation of the neuron at ultra-low currents. In this work, we propose an All-Spin Artificial Neural Network where a single spintronic device acts as the basic building block of the system. The device offers a direct mapping to synapse and neuron functionalities in the brain while inter-layer network communication is accomplished via CMOS transistors. To the best of our knowledge, this is the first demonstration of a neural architecture where a single nanoelectronic device is able to mimic both neurons and synapses. The ultra-low voltage operation of low resistance magneto-metallic neurons enables the low-voltage operation of the array of spintronic synapses, thereby leading to ultra-low power neural architectures. Device-level simulations, calibrated to experimental results, was used to drive the circuit and system level simulations of the neural network for a standard pattern recognition problem. Simulation studies indicate energy savings by  ∼  100× in comparison to a corresponding digital/analog CMOS neuron implementation.

Magnetosphere Modeling: From Cartoons to Simulations

NASA Astrophysics Data System (ADS)

Gombosi, T. I.

2017-12-01

Over the last half a century physics-based global computer simulations became a bridge between experiment and basic theory and now it represents the "third pillar" of geospace research. Today, many of our scientific publications utilize large-scale simulations to interpret observations, test new ideas, plan campaigns, or design new instruments. Realistic simulations of the complex Sun-Earth system have been made possible by the dramatically increased power of both computing hardware and numerical algorithms. Early magnetosphere models were based on simple E&M concepts (like the Chapman-Ferraro cavity) and hydrodynamic analogies (bow shock). At the beginning of the space age current system models were developed culminating in the sophisticated Tsyganenko-type description of the magnetic configuration. The first 3D MHD simulations of the magnetosphere were published in the early 1980s. A decade later there were several competing global models that were able to reproduce many fundamental properties of the magnetosphere. The leading models included the impact of the ionosphere by using a height-integrated electric potential description. Dynamic coupling of global and regional models started in the early 2000s by integrating a ring current and a global magnetosphere model. It has been recognized for quite some time that plasma kinetic effects play an important role. Presently, global hybrid simulations of the dynamic magnetosphere are expected to be possible on exascale supercomputers, while fully kinetic simulations with realistic mass ratios are still decades away. In the 2010s several groups started to experiment with PIC simulations embedded in large-scale 3D MHD models. Presently this integrated MHD-PIC approach is at the forefront of magnetosphere simulations and this technique is expected to lead to some important advances in our understanding of magnetosheric physics. This talk will review the evolution of magnetosphere modeling from cartoons to current systems, to global MHD to MHD-PIC and discuss the role of state-of-the-art models in forecasting space weather.

Computers and Play.

ERIC Educational Resources Information Center

Colker, Larry

Viewing computers in various forms as developmentally appropriate objects for children, this discussion provides a framework for integrating conceptions of computers and conceptions of play. Several instances are cited from the literature in which explicit analogies have been made between computers and playthings or play environments.…

Anatomic Customization of Root-Analog Dental Implants With Cone-Beam CT and CAD/CAM Fabrication: A Cadaver-Based Pilot Evaluation.

PubMed

Evans, Zachary P; Renne, Walter G; Bacro, Thierry R; Mennito, Anthony S; Ludlow, Mark E; Lecholop, Michael K

2018-02-01

Existing root-analog dental implant systems have no standardized protocols regarding retentive design, surface manipulation, or prosthetic attachment design relative to the site's unique anatomy. Historically, existing systems made those design choices arbitrarily. For this report, strategies were developed that deliberately reference the adjacent anatomy, implant and restorable path of draw, and bone density for implant and retentive design. For proof of concept, dentate arches from human cadavers were scanned using cone-beam computed tomography and then digitally modeled. Teeth of interest were virtually extracted and manipulated via computer-aided design to generate root-analog implants from zirconium. We created a stepwise protocol for analyzing and developing the implant sites, implant design and retention, and prosthetic emergence and connection all from the pre-op cone-beam data. Root-analog implants were placed at the time of extraction and examined radiographically and mechanically concerning ideal fit and stability. This study provides proof of concept that retentive root-analog implants can be produced from cone-beam data while improving fit, retention, safety, esthetics, and restorability when compared to the existing protocols. These advancements may provide the critical steps necessary for clinical relevance and success of immediately placed root-analog implants. Additional studies are necessary to validate the model prior to clinical trial.

On the Comparison of the Long Penetration Mode (LPM) Supersonic Counterflowing Jet to the Supersonic Screech Jet

NASA Technical Reports Server (NTRS)

Farr, Rebecca A.; Chang, Chau-Lyan; Jones, Jess H.; Dougherty, N. Sam

2015-01-01

Classic tonal screech noise created by under-expanded supersonic jets; Long Penetration Mode (LPM) supersonic phenomenon -Under-expanded counter-flowing jet in supersonic free stream -Demonstrated in several wind tunnel tests -Modeled in several computational fluid dynamics (CFD) simulations; Discussion of LPM acoustics feedback and fluid interactions -Analogous to the aero-acoustics interactions seen in screech jets; Lessons Learned: Applying certain methodologies to LPM -Developed and successfully demonstrated in the study of screech jets -Discussion of mechanically induced excitation in fluid oscillators in general; Conclusions -Large body of work done on jet screech, other aero-acoustic phenomenacan have direct application to the study and applications of LPM cold flow jets

Ride comfort control in large flexible aircraft. M.S. Thesis

NASA Technical Reports Server (NTRS)

Warren, M. E.

1971-01-01

The problem of ameliorating the discomfort of passengers on a large air transport subject to flight disturbances is examined. The longitudinal dynamics of the aircraft, including effects of body flexing, are developed in terms of linear, constant coefficient differential equations in state variables. A cost functional, penalizing the rigid body displacements and flexure accelerations over the surface of the aircraft is formulated as a quadratic form. The resulting control problem, to minimize the cost subject to the state equation constraints, is of a class whose solutions are well known. The feedback gains for the optimal controller are calculated digitally, and the resulting autopilot is simulated on an analog computer and its performance evaluated.

Laboratory Hydrothermal Alteration of Basaltic Tephra by Acid Sulfate Solutions: An Analog Process for Martian Weathering

NASA Technical Reports Server (NTRS)

Golden, D. C.; Ming, D. W.; Morris, R. V.

2003-01-01

The objective of this study is to conduct simulated Mars-like weathering experiments in the laboratory to determine the weathering products that might form during oxidative, acidic weathering of Mars analog materials.

VORCAM: A computer program for calculating vortex lift effect of cambered wings by the suction analogy

NASA Technical Reports Server (NTRS)

Lan, C. E.; Chang, J. F.

1981-01-01

A user's guide to an improved version of Woodward's chord plane aerodynamic panel computer code is presumed. The guide can be applied to cambered wings exhibiting edge separated flow, including those with leading edge vortex flow at subsonic and supersonic speeds. New orientations for the rotated suction force are employed based on the momentum principal. The supersonic suction analogy method is improved by using an effective angle of attack defined through a semiempirical method.

An Analogy-Based Computer Tutor for Remediating Physics Misconceptions.

ERIC Educational Resources Information Center

Murray, Tom; And Others

1990-01-01

Describes an intelligent tutoring system designed to help students remedy misconceptions of physics concepts based on a teaching strategy called bridging analogies. Highlights include tutoring strategies; misconceptions in science education; the example situation network; confidence checking; formative evaluation with college students, including…

Lessons Learned from Performance Testing of Humans in Spacesuits in Simulated Reduced Gravity

NASA Technical Reports Server (NTRS)

Norcross, Jason R.; Chappell, Steven P.; Gernhardt, Michael L.

2010-01-01

Introduction: The overarching objective of the Integrated Suit Test (IST) series is to evaluate suited human performance using reduced-gravity analogs and learn what aspects of an EVA suit system affect human performance. For this objective to be successfully achieved, the testing methodology should be valid and reproducible, and the partial-gravity simulations must be as accurate and realistic as possible. Objectives: To highlight some of the key lessons learned about partial-gravity analogs and testing methodology, and to suggest considerations for optimizing the effectiveness and quality of results of future tests. Methods: Performance testing of suited and unsuited subjects was undertaken in different reduced-gravity analogs including the Space Vehicle Mockup Facility s Partial Gravity Simulator (POGO), parabolic flight on the C-9 aircraft, underwater environments including NASA s Extreme Environment Mission Operations (NEEMO) and the Neutral Buoyancy Lab (NBL), and in field analogs including Desert Research and Technology Studies (RATS), the Haughton Mars Project (HMP), and the JSC Rock Pile. Subjects performed level walking, incline/decline walking, running, shoveling, picking up and transferring rocks, kneeling/standing, and task boards. Lessons Learned Analogs: No single analog will properly simulate all aspects of the true partial-gravity environment. The POGO is an ideal environment from the standpoint that there are no time limits or significant volumetric constraints, but it does have several limitations. It allows only 2 translational degrees of freedom (DOF) and applies true partial-gravity offload only through the subject s center of gravity (CG). Also, when a subject is doing non-stationary tasks, significant overhead inertia from the lift column seems to have a negative impact on performance. Parabolic flight allows full translational and rotational DOF and applies offload to all parts of the body, but the simulation lasts less than 30 seconds. When this is coupled with the volumetric constraints of the plane, both task selection and data collection options are significantly limited. The underwater environments also allow all 6 DOF and allow off-loading to be applied throughout the body, but the data collection capabilities are limited to little more than subjective ratings. In addition, water drag negatively affects performance of tasks requiring dynamic motion. Field analogs provide the ability to simulate lunar terrain and more realistic mission-like objectives, but all of them operate at 1-g, so suited human performance testing generally must utilize a reduced-mass or "mockup" suit, depending on study objectives. In general, the ground-based overhead-suspension partial-gravity analogs like POGO allow the most diverse data collection methods possible while still simulating partial gravity. However, as currently designed, the POGO has significant limitations. Design of the Active Response Gravity Offload System (ARGOS) has begun and is focusing on adding full x,y,z translational DOF, improved offload accuracy, increased lift capacity, and active control of the x and y axes to minimize offload system inertia. Additionally, a new gimbal is being designed to reduce mass and inertia and to be able to work with different suits, as the current gimbal only supports suited testing with the Mark III Technology Demonstrator Suit (MKIII).

Advanced information society(5)

NASA Astrophysics Data System (ADS)

Tanizawa, Ippei

Based on the advancement of information network technology information communication forms informationalized society giving significant impact on business activities and life style in it. The information network has been backed up technologically by development of computer technology and has got great contribution by enhanced computer technology and communication equipments. Information is transferred by digital and analog methods. Technical development which has brought out multifunctioned modems of communication equipments in analog mode, and construction of advanced information communication network which has come out by joint work of computer and communication under digital technique, are described. The trend in institutional matter and standardization of electrical communication is also described showing some examples of value-added network (VAN).

Mars Analog Mission: Glacier Simulation AMADEE-15 by Austrian Space Forum

NASA Astrophysics Data System (ADS)

Groemer, Gernot; Losiak, Anna; Soucek, Alexander; Plank, Clemens; Zanardini, Laura; Sejkora, Nina; Sams, Sebastian

2016-04-01

Austrian Space Forum: The Austrian Space Forum (OeWF, Österreichisches Weltraum Forum) is a non-profit, citizen-science organization of aerospace specialists and enthusiasts. One of its specialisations is Mars analog research. Analog studies and analog instrument validation supported all planetary surface missions so far [1] and are considered as an effective tool to prepare for future missions to Mars [2,3,4,5,6,7]. Since 2006, OeWF has conducted 11 Mars analog field campaigns in diverse locations that represented: 1) average current Mars conditions (the Mars Desert Research Station (MDRS) in Utah in 2006 [8] and the Northern Sahara near Erfoud, Morocco in 2013 [9]); 2) the early and wet Mars (analog site of Rio Tinto Spain in 2011 [10]); and 3) subsurface exploration (Dachstein Ice Caves in 2012). During these campaigns, 68 experiments and major engineering tests were performed, whichwere mostly focused on astrobiology, robotics, human factors, geoscience and spacesuit operations. Major assets of OeWF include two advanced spacesuit simulators Aouda [11], an increasingly evolving Mission Support Center, a dedicated Remote Science Support team [12], and a growing set of Standard Operating Procedures defining major workflows within a mission team. The spacesuit simulators were operated by a total of 18 analog astronauts, who were selected and trained during a >6 month program. Total EVA time is nearly 600 hours, leading to a significant experience in analog field simulations. AMADEE-15: The mission took place between August 2nd and 14th 2015 at the Kaunertal Glacier in Tyrol, Austria. This glacier was selected as a study site because of its accessibility and high number of micro-landscapes analogous to those expected on Mars in locations where abundant water ice is present. As such it is considered a first-tier Mars analog [13]. The Base station was located at N 46.86320, E 10.71401 at 2800 masl, the highest reached location was on elevation of 2887 m. Eleven experiments were conducted by a field crew at the test site under simulated Martian surface exploration conditions, coordinated by the Mission Support Center in Innsbruck, Austria. A 10-minute satellite communication delay and other limitations pertinent to human planetary surface activities were introduced. A detailed description of the mission should be soon published in [14]. References: [1] Preston & Dartnell 2014. Int. J. Astrobiol. 13:81-98. [2] Drake et al. 2009. NASA-SP-2009-566.pdf. [3] Ross et al. 2013. Act. Astronaut. 90:182-202. [4] Abercromby et al. 2013. Act. Astronaut. 91:34-48. [5] Binstead et al. 2015. Human Research Program Investigators Workshop. [6] Imhof et al. 2015. AIAA SPACE 2015 Conference and Exposition. [7] Bessone et al. 2015. 10.1007/978-3-319-15982-9_37. [8] Groemer et al. 2007. AustroMars Sci. Worksh.:4-12. [9] Groemer et al. 2014. Astrobiol. 14:360-376. [10] Orgel et al. 2013. Act. Astronaut. 94:736-748. [11] Groemer et al. 2012. Astrobiol. 12(2):125-134. [12] Losiak et al. 2014. Astrobiol. 14:417-430. [13] Soare et al. 2001. EOS82, 501. [14] Gernot et al. 2016. Act. Astronaut. (in review).

A new framework for comprehensive, robust, and efficient global sensitivity analysis: 1. Theory

NASA Astrophysics Data System (ADS)

Razavi, Saman; Gupta, Hoshin V.

2016-01-01

Computer simulation models are continually growing in complexity with increasingly more factors to be identified. Sensitivity Analysis (SA) provides an essential means for understanding the role and importance of these factors in producing model responses. However, conventional approaches to SA suffer from (1) an ambiguous characterization of sensitivity, and (2) poor computational efficiency, particularly as the problem dimension grows. Here, we present a new and general sensitivity analysis framework (called VARS), based on an analogy to "variogram analysis," that provides an intuitive and comprehensive characterization of sensitivity across the full spectrum of scales in the factor space. We prove, theoretically, that Morris (derivative-based) and Sobol (variance-based) methods and their extensions are special cases of VARS, and that their SA indices can be computed as by-products of the VARS framework. Synthetic functions that resemble actual model response surfaces are used to illustrate the concepts, and show VARS to be as much as two orders of magnitude more computationally efficient than the state-of-the-art Sobol approach. In a companion paper, we propose a practical implementation strategy, and demonstrate the effectiveness, efficiency, and reliability (robustness) of the VARS framework on real-data case studies.

Inelastic strain analogy for piecewise linear computation of creep residues in built-up structures

NASA Technical Reports Server (NTRS)

Jenkins, Jerald M.

1987-01-01

An analogy between inelastic strains caused by temperature and those caused by creep is presented in terms of isotropic elasticity. It is shown how the theoretical aspects can be blended with existing finite-element computer programs to exact a piecewise linear solution. The creep effect is determined by using the thermal stress computational approach, if appropriate alterations are made to the thermal expansion of the individual elements. The overall transient solution is achieved by consecutive piecewise linear iterations. The total residue caused by creep is obtained by accumulating creep residues for each iteration and then resubmitting the total residues for each element as an equivalent input. A typical creep law is tested for incremental time convergence. The results indicate that the approach is practical, with a valid indication of the extent of creep after approximately 20 hr of incremental time. The general analogy between body forces and inelastic strain gradients is discussed with respect to how an inelastic problem can be worked as an elastic problem.

Quantum dynamical simulation of the scattering of Ar from a frozen LiF(100) surface based on a first principles interaction potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Azuri, Asaf; Pollak, Eli, E-mail: eli.pollak@weizmann.ac.il

2015-07-07

In-plane two and three dimensional diffraction patterns are computed for the vertical scattering of an Ar atom from a frozen LiF(100) surface. Suitable collimation of the incoming wavepacket serves to reveal the quantum mechanical diffraction. The interaction potential is based on a fit to an ab initio potential calculated using density functional theory with dispersion corrections. Due to the potential coupling found between the two horizontal surface directions, there are noticeable differences between the quantum angular distributions computed for two and three dimensional scattering. The quantum results are compared to analogous classical Wigner computations on the same surface and withmore » the same conditions. The classical dynamics largely provides the envelope for the quantum diffractive scattering. The classical results also show that the corrugation along the [110] direction of the surface is smaller than along the [100] direction, in qualitative agreement with experimental observations of unimodal and bimodal scattering for the [110] and [100] directions, respectively.« less

Orientation-selective aVLSI spiking neurons.

PubMed

Liu, S C; Kramer, J; Indiveri, G; Delbrück, T; Burg, T; Douglas, R

2001-01-01

We describe a programmable multi-chip VLSI neuronal system that can be used for exploring spike-based information processing models. The system consists of a silicon retina, a PIC microcontroller, and a transceiver chip whose integrate-and-fire neurons are connected in a soft winner-take-all architecture. The circuit on this multi-neuron chip approximates a cortical microcircuit. The neurons can be configured for different computational properties by the virtual connections of a selected set of pixels on the silicon retina. The virtual wiring between the different chips is effected by an event-driven communication protocol that uses asynchronous digital pulses, similar to spikes in a neuronal system. We used the multi-chip spike-based system to synthesize orientation-tuned neurons using both a feedforward model and a feedback model. The performance of our analog hardware spiking model matched the experimental observations and digital simulations of continuous-valued neurons. The multi-chip VLSI system has advantages over computer neuronal models in that it is real-time, and the computational time does not scale with the size of the neuronal network.

Estimation of Nutation Time Constant Model Parameters for On-Axis Spinning Spacecraft

NASA Technical Reports Server (NTRS)

Schlee, Keith; Sudermann, James

2008-01-01

Calculating an accurate nutation time constant for a spinning spacecraft is an important step for ensuring mission success. Spacecraft nutation is caused by energy dissipation about the spin axis. Propellant slosh in the spacecraft fuel tanks is the primary source for this dissipation and can be simulated using a forced motion spin table. Mechanical analogs, such as pendulums and rotors, are typically used to simulate propellant slosh. A strong desire exists for an automated method to determine these analog parameters. The method presented accomplishes this task by using a MATLAB Simulink/SimMechanics based simulation that utilizes the Parameter Estimation Tool.

Basalt: Biologic Analog Science Associated with Lava Terrains

NASA Astrophysics Data System (ADS)

Lim, D. S. S.; Abercromby, A.; Kobs-Nawotniak, S. E.; Kobayashi, L.; Hughes, S. S.; Chappell, S.; Bramall, N. E.; Deans, M. C.; Heldmann, J. L.; Downs, M.; Cockell, C. S.; Stevens, A. H.; Caldwell, B.; Hoffman, J.; Vadhavk, N.; Marquez, J.; Miller, M.; Squyres, S. W.; Lees, D. S.; Fong, T.; Cohen, T.; Smith, T.; Lee, G.; Frank, J.; Colaprete, A.

2015-12-01

This presentation will provide an overview of the BASALT (Biologic Analog Science Associated with Lava Terrains) program. BASALT research addresses Science, Science Operations, and Technology. Specifically, BASALT is focused on the investigation of terrestrial volcanic terrains and their habitability as analog environments for early and present-day Mars. Our scientific fieldwork is conducted under simulated Mars mission constraints to evaluate strategically selected concepts of operations (ConOps) and capabilities with respect to their anticipated value for the joint human and robotic exploration of Mars. a) Science: The BASALT science program is focused on understanding habitability conditions of early and present-day Mars in two relevant Mars-analog locations (the Southwest Rift Zone (SWRZ) and the East Rift Zone (ERZ) flows on the Big Island of Hawai'i and the eastern Snake River Plain (ESRP) in Idaho) to characterize and compare the physical and geochemical conditions of life in these environments and to learn how to seek, identify, and characterize life and life-related chemistry in basaltic environments representing these two epochs of martian history. b) Science Operations: The BASALT team will conduct real (non-simulated) biological and geological science at two high-fidelity Mars analogs, all within simulated Mars mission conditions (including communication latencies and bandwidth constraints) that are based on current architectural assumptions for Mars exploration missions. We will identify which human-robotic ConOps and supporting capabilities enable science return and discovery. c) Technology: BASALT will incorporate and evaluate technologies in to our field operations that are directly relevant to conducting the scientific investigations regarding life and life-related chemistry in Mars-analogous terrestrial environments. BASALT technologies include the use of mobile science platforms, extravehicular informatics, display technologies, communication & navigation packages, remote sensing, advanced science mission planning tools, and scientifically-relevant instrument packages to achieve the project goals.

Photometric study of cometary analogs in the LOSSy laboratory at the University of Bern

NASA Astrophysics Data System (ADS)

Pommerol, A.; Thomas, N.; Jost, B.; Poch, O.

2014-07-01

We have set up the LOSSy laboratory (Laboratory for Outflow Studies of Sublimating Materials) to study the spectro-photometric properties of various analogs of planetary-object surfaces, with a special emphasis on icy samples and their evolution under simulated space conditions. This laboratory is currently equipped with two facilities: the PHIRE-2 radio-goniometer, designed to measure the bidirectional visible reflectance of samples under a wide range of geometries and the SCITEAS simulation chamber, designed to follow the evolution of icy samples subliming under low temperature and low pressure conditions by means of VIS-NIR hyperspectral imaging. We will report on the characterization of cometary analogs using both facilities. We produce these analogs by mixing in various proportions fine-grained ice, mineral and organic matter. Various preparation protocols have been defined to produce different textures of sample. Using the PHIRE-2 radio-goniometer, we are building a catalog of bidirectional reflectance data for various cometary analogs, varying by steps the different parameters susceptible to affect the reflectance phase function. In particular, we have recently upgraded the instrument to be able to characterize in detail the opposition effect by allowing measurements of the reflectance at very low phase angle. This laboratory dataset is intended to be used for the analysis of the data acquired by the OSIRIS imager onboard Rosetta. Using the SCITEAS simulation chamber, we have followed for 30 hours the evolution of a cometary analog placed under secondary vacuum (<10^{-6} mbar) and maintained at low temperature (170-200 K) for more than 30 hours. We analyzed the temporal evolution of the morphology and the photometry of the surface of the sample to identify which processes affect the surfaces of cometary nuclei during sublimation and how they affect their visible and near-infrared surface properties.

Evaluation of protein-ligand affinity prediction using steered molecular dynamics simulations.

PubMed

Okimoto, Noriaki; Suenaga, Atsushi; Taiji, Makoto

2017-11-01

In computational drug design, ranking a series of compound analogs in a manner that is consistent with experimental affinities remains a challenge. In this study, we evaluated the prediction of protein-ligand binding affinities using steered molecular dynamics simulations. First, we investigated the appropriate conditions for accurate predictions in these simulations. A conic harmonic restraint was applied to the system for efficient sampling of work values on the ligand unbinding pathway. We found that pulling velocity significantly influenced affinity predictions, but that the number of collectable trajectories was less influential. We identified the appropriate pulling velocity and collectable trajectories for binding affinity predictions as 1.25 Å/ns and 100, respectively, and these parameters were used to evaluate three target proteins (FK506 binding protein, trypsin, and cyclin-dependent kinase 2). For these proteins using our parameters, the accuracy of affinity prediction was higher and more stable when Jarzynski's equality was employed compared with the second-order cumulant expansion equation of Jarzynski's equality. Our results showed that steered molecular dynamics simulations are effective for predicting the rank order of ligands; thus, they are a potential tool for compound selection in hit-to-lead and lead optimization processes.

Analysis of periodically excited non-linear systems by a parametric continuation technique

NASA Astrophysics Data System (ADS)

Padmanabhan, C.; Singh, R.

1995-07-01

The dynamic behavior and frequency response of harmonically excited piecewise linear and/or non-linear systems has been the subject of several recent investigations. Most of the prior studies employed harmonic balance or Galerkin schemes, piecewise linear techniques, analog simulation and/or direct numerical integration (digital simulation). Such techniques are somewhat limited in their ability to predict all of the dynamic characteristics, including bifurcations leading to the occurrence of unstable, subharmonic, quasi-periodic and/or chaotic solutions. To overcome this problem, a parametric continuation scheme, based on the shooting method, is applied specifically to a periodically excited piecewise linear/non-linear system, in order to improve understanding as well as to obtain the complete dynamic response. Parameter regions exhibiting bifurcations to harmonic, subharmonic or quasi-periodic solutions are obtained quite efficiently and systematically. Unlike other techniques, the proposed scheme can follow period-doubling bifurcations, and with some modifications obtain stable quasi-periodic solutions and their bifurcations. This knowledge is essential in establishing conditions for the occurrence of chaotic oscillations in any non-linear system. The method is first validated through the Duffing oscillator example, the solutions to which are also obtained by conventional one-term harmonic balance and perturbation methods. The second example deals with a clearance non-linearity problem for both harmonic and periodic excitations. Predictions from the proposed scheme match well with available analog simulation data as well as with multi-term harmonic balance results. Potential savings in computational time over direct numerical integration is demonstrated for some of the example cases. Also, this work has filled in some of the solution regimes for an impact pair, which were missed previously in the literature. Finally, one main limitation associated with the proposed procedure is discussed.

A Software Defined Radio Based Airplane Communication Navigation Simulation System

NASA Astrophysics Data System (ADS)

He, L.; Zhong, H. T.; Song, D.

2018-01-01

Radio communication and navigation system plays important role in ensuring the safety of civil airplane in flight. Function and performance should be tested before these systems are installed on-board. Conventionally, a set of transmitter and receiver are needed for each system, thus all the equipment occupy a lot of space and are high cost. In this paper, software defined radio technology is applied to design a common hardware communication and navigation ground simulation system, which can host multiple airplane systems with different operating frequency, such as HF, VHF, VOR, ILS, ADF, etc. We use a broadband analog frontend hardware platform, universal software radio peripheral (USRP), to transmit/receive signal of different frequency band. Software is compiled by LabVIEW on computer, which interfaces with USRP through Ethernet, and is responsible for communication and navigation signal processing and system control. An integrated testing system is established to perform functional test and performance verification of the simulation signal, which demonstrate the feasibility of our design. The system is a low-cost and common hardware platform for multiple airplane systems, which provide helpful reference for integrated avionics design.

Robotic lower limb prosthesis design through simultaneous computer optimizations of human and prosthesis costs

NASA Astrophysics Data System (ADS)

Handford, Matthew L.; Srinivasan, Manoj

2016-02-01

Robotic lower limb prostheses can improve the quality of life for amputees. Development of such devices, currently dominated by long prototyping periods, could be sped up by predictive simulations. In contrast to some amputee simulations which track experimentally determined non-amputee walking kinematics, here, we explicitly model the human-prosthesis interaction to produce a prediction of the user’s walking kinematics. We obtain simulations of an amputee using an ankle-foot prosthesis by simultaneously optimizing human movements and prosthesis actuation, minimizing a weighted sum of human metabolic and prosthesis costs. The resulting Pareto optimal solutions predict that increasing prosthesis energy cost, decreasing prosthesis mass, and allowing asymmetric gaits all decrease human metabolic rate for a given speed and alter human kinematics. The metabolic rates increase monotonically with speed. Remarkably, by performing an analogous optimization for a non-amputee human, we predict that an amputee walking with an appropriately optimized robotic prosthesis can have a lower metabolic cost - even lower than assuming that the non-amputee’s ankle torques are cost-free.

INTEGRITY - Integrated Human Exploration Mission Simulation Facility

NASA Technical Reports Server (NTRS)

Henninger, Donald L.

2002-01-01

It is proposed to develop a high-fidelity ground facility to carry out long-duration human exploration mission simulations. These would not be merely computer simulations - they would in fact comprise a series of actual missions that just happen to stay on earth. These missions would include all elements of an actual mission, using actual technologies that would be used for the real mission. These missions would also include such elements as extravehicular activities, robotic systems, telepresence and teleoperation, surface drilling technology-all using a simulated planetary landscape. A sequence of missions would be defined that get progressively longer and more robust, perhaps a series of five or six missions over a span of 10 to 15 years ranging in duration from 180 days up to 1000 days. This high-fidelity ground facility would operate hand-in-hand with a host of other terrestrial analog sites such as the Antarctic, Haughton Crater, and the Arizona desert. Of course, all of these analog mission simulations will be conducted here on earth in 1-g, and NASA will still need the Shuttle and ISS to carry out all the microgravity and hypogravity science experiments and technology validations. The proposed missions would have sufficient definition such that definitive requirements could be derived from them to serve as direction for all the program elements of the mission. Additionally, specific milestones would be established for the "launch" date of each mission so that R&D programs would have both good requirements and solid milestones from which to .build their implementation plans. Mission aspects that could not be directly incorporated into the ground facility would be simulated via software. New management techniques would be developed for evaluation in this ground test facility program. These new techniques would have embedded metrics which would allow them to be continuously evaluated and adjusted so that by the time the sequence of missions is completed, the best management techniques will have been developed, implemented, and validated. A trained cadre of managers experienced with a large, complex program would then be available.

Computer Technology-Integrated Projects Should not Supplant Craft Projects in Science Education

NASA Astrophysics Data System (ADS)

Klopp, Tabatha J.; Rule, Audrey C.; Suchsland Schneider, Jean; Boody, Robert M.

2014-03-01

The current emphasis on computer technology integration and narrowing of the curriculum has displaced arts and crafts. However, the hands-on, concrete nature of craft work in science modeling enables students to understand difficult concepts and to be engaged and motivated while learning spatial, logical, and sequential thinking skills. Analogy use is also helpful in understanding unfamiliar, complex science concepts. This study of 28 academically advanced elementary to middle-school students examined student work and perceptions during a science unit focused on four fossil organisms: crinoid, brachiopod, horn coral and trilobite. The study compared: (1) analogy-focused instruction to independent Internet research and (2) computer technology-rich products to crafts-based products. Findings indicate student products were more creative after analogy-based instruction and when made using technology. However, students expressed a strong desire to engage in additional craft work after making craft products and enjoyed making crafts more after analogy-focused instruction. Additionally, more science content was found in the craft products than the technology-rich products. Students expressed a particular liking for two of the fossil organisms because they had been modeled with crafts. The authors recommend that room should be retained for crafts in the science curriculum to model science concepts.

Arterial Pressure Analog.

ERIC Educational Resources Information Center

Heusner, A. A.; Tracy, M. L.

1980-01-01

Describes a simple hydraulic analog which allows students to explore some physical aspects of the cardiovascular system and provides them with a means to visualize and conceptualize these basic principles. Simulates the behavior of arterial pressure in response to changes in heart rate, stroke volume, arterial compliance, and peripheral…

Xyce Parallel Electronic Simulator : users' guide, version 2.0.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoekstra, Robert John; Waters, Lon J.; Rankin, Eric Lamont

2004-06-01

This manual describes the use of the Xyce Parallel Electronic Simulator. Xyce has been designed as a SPICE-compatible, high-performance analog circuit simulator capable of simulating electrical circuits at a variety of abstraction levels. Primarily, Xyce has been written to support the simulation needs of the Sandia National Laboratories electrical designers. This development has focused on improving capability the current state-of-the-art in the following areas: {sm_bullet} Capability to solve extremely large circuit problems by supporting large-scale parallel computing platforms (up to thousands of processors). Note that this includes support for most popular parallel and serial computers. {sm_bullet} Improved performance for allmore » numerical kernels (e.g., time integrator, nonlinear and linear solvers) through state-of-the-art algorithms and novel techniques. {sm_bullet} Device models which are specifically tailored to meet Sandia's needs, including many radiation-aware devices. {sm_bullet} A client-server or multi-tiered operating model wherein the numerical kernel can operate independently of the graphical user interface (GUI). {sm_bullet} Object-oriented code design and implementation using modern coding practices that ensure that the Xyce Parallel Electronic Simulator will be maintainable and extensible far into the future. Xyce is a parallel code in the most general sense of the phrase - a message passing of computing platforms. These include serial, shared-memory and distributed-memory parallel implementation - which allows it to run efficiently on the widest possible number parallel as well as heterogeneous platforms. Careful attention has been paid to the specific nature of circuit-simulation problems to ensure that optimal parallel efficiency is achieved as the number of processors grows. One feature required by designers is the ability to add device models, many specific to the needs of Sandia, to the code. To this end, the device package in the Xyce These input formats include standard analytical models, behavioral models look-up Parallel Electronic Simulator is designed to support a variety of device model inputs. tables, and mesh-level PDE device models. Combined with this flexible interface is an architectural design that greatly simplifies the addition of circuit models. One of the most important feature of Xyce is in providing a platform for computational research and development aimed specifically at the needs of the Laboratory. With Xyce, Sandia now has an 'in-house' capability with which both new electrical (e.g., device model development) and algorithmic (e.g., faster time-integration methods) research and development can be performed. Ultimately, these capabilities are migrated to end users.« less

On Processing Hexagonally Sampled Images

DTIC Science & Technology

2011-07-01

Mersereau’s HDFT: Mersereau encountered an “insurmountable difficulty” when attempting to develop a fast algorithm to compute the hexagonal DFT...WNR GND 1-bit output CS1 . ------. (input for analog) j(-- -: I (analog out) ADC ,. __ I I I I l ______ l Power to Firefly C1 ~2 TT

Analog Spectrophotometers in the Digital Age: Data Acquisition on a Budget

ERIC Educational Resources Information Center

Nazarenko, Alexander Y.; Nazarenko, Natalie A.

2005-01-01

The interfacing of various spectrometers with analog output to a personal computer running Microsoft Excel in the Windows environment is described. This low cost data acquisition solution is a useful replacement of a chart recorder for various UV-visible and infrared scanning spectrophotometers.

Comparison Between 2D and 3D Simulations of Rate Dependent Friction Using DEM

NASA Astrophysics Data System (ADS)

Wang, C.; Elsworth, D.

2017-12-01

Rate-state dependent constitutive laws of frictional evolution have been successful in representing many of the first- and second- order components of earthquake rupture. Although this constitutive law has been successfully applied in numerical models, difficulty remains in efficient implementation of this constitutive law in computationally-expensive granular mechanics simulations using discrete element methods (DEM). This study introduces a novel approach in implementing a rate-dependent constitutive relation of contact friction into DEM. This is essentially an implementation of a slip-weakening constitutive law onto local particle contacts without sacrificing computational efficiency. This implementation allows the analysis of slip stability of simulated fault gouge materials. Velocity-stepping experiments are reported on both uniform and textured distributions of quartz and talc as 3D analogs of gouge mixtures. Distinct local slip stability parameters (a-b) are assigned to the quartz and talc, respectively. We separately vary talc content from 0 to 100% in the uniform mixtures and talc layer thickness from 1 to 20 particles in the textured mixtures. Applied shear displacements are cycled through velocities of 1μm/s and 10μm/s. Frictional evolution data are collected and compared to 2D simulation results. We show that dimensionality significantly impacts the evolution of friction. 3D simulation results are more representative of laboratory observed behavior and numerical noise is shown at a magnitude of 0.01 in terms of friction coefficient. Stability parameters (a-b) can be straightforwardly obtained from analyzing velocity steps, and are different from locally assigned (a-b) values. Sensitivity studies on normal stress, shear velocity, particle size, local (a-b) values, and characteristic slip distance (Dc) show that the implementation is sensitive to local (a-b) values and relations between (Dc) and particle size.

Cloud computing and validation of expandable in silico livers.

PubMed

Ropella, Glen E P; Hunt, C Anthony

2010-12-03

In Silico Livers (ISLs) are works in progress. They are used to challenge multilevel, multi-attribute, mechanistic hypotheses about the hepatic disposition of xenobiotics coupled with hepatic responses. To enhance ISL-to-liver mappings, we added discrete time metabolism, biliary elimination, and bolus dosing features to a previously validated ISL and initiated re-validated experiments that required scaling experiments to use more simulated lobules than previously, more than could be achieved using the local cluster technology. Rather than dramatically increasing the size of our local cluster we undertook the re-validation experiments using the Amazon EC2 cloud platform. So doing required demonstrating the efficacy of scaling a simulation to use more cluster nodes and assessing the scientific equivalence of local cluster validation experiments with those executed using the cloud platform. The local cluster technology was duplicated in the Amazon EC2 cloud platform. Synthetic modeling protocols were followed to identify a successful parameterization. Experiment sample sizes (number of simulated lobules) on both platforms were 49, 70, 84, and 152 (cloud only). Experimental indistinguishability was demonstrated for ISL outflow profiles of diltiazem using both platforms for experiments consisting of 84 or more samples. The process was analogous to demonstration of results equivalency from two different wet-labs. The results provide additional evidence that disposition simulations using ISLs can cover the behavior space of liver experiments in distinct experimental contexts (there is in silico-to-wet-lab phenotype similarity). The scientific value of experimenting with multiscale biomedical models has been limited to research groups with access to computer clusters. The availability of cloud technology coupled with the evidence of scientific equivalency has lowered the barrier and will greatly facilitate model sharing as well as provide straightforward tools for scaling simulations to encompass greater detail with no extra investment in hardware.

UV–Vis Light-induced Aging of Titan’s Haze and Ice

NASA Astrophysics Data System (ADS)

Couturier-Tamburelli, Isabelle; Piétri, Nathalie; Le Letty, Vincent; Chiavassa, Thierry; Gudipati, Murthy

2018-01-01

The study of the photochemical aging of aerosols is an important tool for understanding Titan’s stratosphere/troposphere composition and evolution, particularly the haze. Laboratory simulations of the photoreactivity of the haze aerosol analogs provide insight into the photochemical evolution of Titan’s atmosphere at and below the haze layers. Here we use experimental simulations to investigate the evolution of the laboratory analogs of these organic aerosols under ultraviolet (UV)–visible (Vis) photons, which make it through the haze layers during their sedimentation process. We present experimental results for the aging of Titan’s aerosol analogs obtained from two dominant nitrogen-containing organics, HC3N and HCN, under simulated Titan atmospheric conditions (photons and temperature). We report that volatile nitriles condensed on haze particles could be incorporated through photochemistry and provide one such sink mechanism for nitrile compounds. We provide laboratory evidence that the organic aerosols could photochemically evolve during their sedimentation through Titan’s atmosphere.

SSERVI Analog Regolith Simulant Testbed Facility

NASA Astrophysics Data System (ADS)

Minafra, Joseph; Schmidt, Gregory; Bailey, Brad; Gibbs, Kristina

2016-10-01

The Solar System Exploration Research Virtual Institute (SSERVI) at NASA's Ames Research Center in California's Silicon Valley was founded in 2013 to act as a virtual institute that provides interdisciplinary research centered on the goals of its supporting directorates: NASA Science Mission Directorate (SMD) and the Human Exploration & Operations Mission Directorate (HEOMD).Primary research goals of the Institute revolve around the integration of science and exploration to gain knowledge required for the future of human space exploration beyond low Earth orbit. SSERVI intends to leverage existing JSC1A regolith simulant resources into the creation of a regolith simulant testbed facility. The purpose of this testbed concept is to provide the planetary exploration community with a readily available capability to test hardware and conduct research in a large simulant environment.SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers.SSERVI provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment.The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area, including dust mitigation and safety oversight.Facility hardware and environment testing scenarios could include, Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, Surface features (i.e. grades and rocks)Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and planetary exploration activities at NASA Research Park, to academia and expanded commercial opportunities, as well as public outreach and education opportunities.

Oxygen monitor for semi-closed rebreathers: design and use for estimating metabolic oxygen consumption

NASA Astrophysics Data System (ADS)

Clarke, John R.; Southerland, David

1999-07-01

Semi-closed circuit underwater breathing apparatus (UBA) provide a constant flow of mixed gas containing oxygen and nitrogen or helium to a diver. However, as a diver's work rate and metabolic oxygen consumption varies, the oxygen percentages within the UBA can change dramatically. Hence, even a resting diver can become hypoxic and become at risk for oxygen induced seizures. Conversely, a hard working diver can become hypoxic and lose consciousness. Unfortunately, current semi-closed UBA do not contain oxygen monitors. We describe a simple oxygen monitoring system designed and prototyped at the Navy Experimental Diving Unit. The main monitor components include a PIC microcontroller, analog-to-digital converter, bicolor LED, and oxygen sensor. The LED, affixed to the diver's mask is steady green if the oxygen partial pressure is within pre- defined acceptable limits. A more advanced monitor with a depth senor and additional computational circuitry could be used to estimate metabolic oxygen consumption. The computational algorithm uses the oxygen partial pressure and the diver's depth to compute O2 using the steady state solution of the differential equation describing oxygen concentrations within the UBA. Consequently, dive transients induce errors in the O2 estimation. To evalute these errors, we used a computer simulation of semi-closed circuit UBA dives to generate transient rich data as input to the estimation algorithm. A step change in simulated O2 elicits a monoexponential change in the estimated O2 with a time constant of 5 to 10 minutes. Methods for predicting error and providing a probable error indication to the diver are presented.

Computational study on cortical spreading depression based on a generalized cellular automaton model

NASA Astrophysics Data System (ADS)

Chen, Shangbin; Hu, Lele; Li, Bing; Xu, Changcheng; Liu, Qian

2009-02-01

Cortical spreading depression (CSD) is an important neurophysiological phenomenon correlating with some neural disorders, such as migraine, cerebral ischemia and epilepsy. By now, we are still not clear about the mechanisms of CSD's initiation and propagation, also the relevance between CSD and those neural diseases. Nevertheless, characterization of CSD, especially the spatiotemporal evolution, will promote the understanding of the CSD's nature and mechanisms. Besides the previous experimental work on charactering the spatiotemporal evolution of CSD in rats by optical intrinsic signal imaging, a computational study based on a generalized cellular automaton (CA) model was proposed here. In the model, we exploited a generalized neighborhood connection rule: a central CA cell is related with a group of surrounding CA cells with different weight coefficients. By selecting special parameters, the generalized CA model could be transformed to the traditional CA models with von Neumann, Moore and hexagon neighborhood connection means. Hence, the new model covered several properties of CSD simulated in traditional CA models: 1) expanding from the origin site like a circular wave; 2) annihilation of two waves traveling in opposite directions after colliding; 3) wavefront of CSD breaking and recovering when and after encountering an obstacle. By setting different refractory period in the different CA lattice field, different connection coefficient in different direction within the defined neighborhood, inhomogeneous propagation of CSD was simulated with high fidelity. The computational results were analogous to the reported time-varying CSD waves by optical imaging. So, the generalized CA model would be useful to study CSD because of its intuitive appeal and computational efficiency.

Injecting Computational Thinking into Computing Activities for Middle School Girls

ERIC Educational Resources Information Center

Webb, Heidi Cornelia

2013-01-01

Advances in technology have caused high schools to update their computer science curricula; however there has been little analogous attention to technology-related education in middle schools. With respect to computer-related knowledge and skills, middle school students are at a critical phase in life, exploring individualized education options…

A DDC Bibliography on Computers in Information Sciences. Volume II. Information Sciences Series.

ERIC Educational Resources Information Center

Defense Documentation Center, Alexandria, VA.

The unclassified and unlimited bibliography compiles references dealing specifically with the role of computers in information sciences. The volume contains 239 annotated references grouped under three major headings: Artificial and Programming Languages, Computer Processing of Analog Data, and Computer Processing of Digital Data. The references…

Numerical Simulation of a High Mach Number Jet Flow

NASA Technical Reports Server (NTRS)

Hayder, M. Ehtesham; Turkel, Eli; Mankbadi, Reda R.

1993-01-01

The recent efforts to develop accurate numerical schemes for transition and turbulent flows are motivated, among other factors, by the need for accurate prediction of flow noise. The success of developing high speed civil transport plane (HSCT) is contingent upon our understanding and suppression of the jet exhaust noise. The radiated sound can be directly obtained by solving the full (time-dependent) compressible Navier-Stokes equations. However, this requires computational storage that is beyond currently available machines. This difficulty can be overcome by limiting the solution domain to the near field where the jet is nonlinear and then use acoustic analogy (e.g., Lighthill) to relate the far-field noise to the near-field sources. The later requires obtaining the time-dependent flow field. The other difficulty in aeroacoustics computations is that at high Reynolds numbers the turbulent flow has a large range of scales. Direct numerical simulations (DNS) cannot obtain all the scales of motion at high Reynolds number of technological interest. However, it is believed that the large scale structure is more efficient than the small-scale structure in radiating noise. Thus, one can model the small scales and calculate the acoustically active scales. The large scale structure in the noise-producing initial region of the jet can be viewed as a wavelike nature, the net radiated sound is the net cancellation after integration over space. As such, aeroacoustics computations are highly sensitive to errors in computing the sound sources. It is therefore essential to use a high-order numerical scheme to predict the flow field. The present paper presents the first step in a ongoing effort to predict jet noise. The emphasis here is in accurate prediction of the unsteady flow field. We solve the full time-dependent Navier-Stokes equations by a high order finite difference method. Time accurate spatial simulations of both plane and axisymmetric jet are presented. Jet Mach numbers of 1.5 and 2.1 are considered. Reynolds number in the simulations was about a million. Our numerical model is based on the 2-4 scheme by Gottlieb & Turkel. Bayliss et al. applied the 2-4 scheme in boundary layer computations. This scheme was also used by Ragab and Sheen to study the nonlinear development of supersonic instability waves in a mixing layer. In this study, we present two dimensional direct simulation results for both plane and axisymmetric jets. These results are compared with linear theory predictions. These computations were made for near nozzle exit region and velocity in spanwise/azimuthal direction was assumed to be zero.

Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses.

PubMed

Zhou, Xinrui; Zheng, Jie; Ivan, Fransiskus Xaverius; Yin, Rui; Ranganathan, Shoba; Chow, Vincent T K; Kwoh, Chee-Keong

2018-05-09

Influenza viruses are undergoing continuous and rapid evolution. The fatal influenza A/H7N9 has drawn attention since the first wave of infections in March 2013, and raised more grave concerns with its increased potential to spread among humans. Experimental studies have revealed several host and virulence markers, indicating differential host binding preferences which can help estimate the potential of causing a pandemic. Here we systematically investigate the sequence pattern and structural characteristics of novel influenza A/H7N9 using computational approaches. The sequence analysis highlighted mutations in protein functional domains of influenza viruses. Molecular docking and molecular dynamics simulation revealed that the hemagglutinin (HA) of A/Taiwan/1/2017(H7N9) strain enhanced the binding with both avian and human receptor analogs, compared with the previous A/Shanghai/02/2013(H7N9) strain. The Molecular Mechanics - Poisson Boltzmann Surface Area (MM-PBSA) calculation revealed the change of residue-ligand interaction energy and detected the residues with conspicuous binding preference. The results are novel and specific to the emerging influenza A/Taiwan/1/2017(H7N9) strain compared with A/Shanghai/02/2013(H7N9). Its enhanced ability to bind human receptor analogs, which are abundant in the human upper respiratory tract, may be responsible for the recent outbreak. Residues showing binding preference were detected, which could facilitate monitoring the circulating influenza viruses.

Microprocessor-based integration of microfluidic control for the implementation of automated sensor monitoring and multithreaded optimization algorithms.

PubMed

Ezra, Elishai; Maor, Idan; Bavli, Danny; Shalom, Itai; Levy, Gahl; Prill, Sebastian; Jaeger, Magnus S; Nahmias, Yaakov

2015-08-01

Microfluidic applications range from combinatorial synthesis to high throughput screening, with platforms integrating analog perfusion components, digitally controlled micro-valves and a range of sensors that demand a variety of communication protocols. Currently, discrete control units are used to regulate and monitor each component, resulting in scattered control interfaces that limit data integration and synchronization. Here, we present a microprocessor-based control unit, utilizing the MS Gadgeteer open framework that integrates all aspects of microfluidics through a high-current electronic circuit that supports and synchronizes digital and analog signals for perfusion components, pressure elements, and arbitrary sensor communication protocols using a plug-and-play interface. The control unit supports an integrated touch screen and TCP/IP interface that provides local and remote control of flow and data acquisition. To establish the ability of our control unit to integrate and synchronize complex microfluidic circuits we developed an equi-pressure combinatorial mixer. We demonstrate the generation of complex perfusion sequences, allowing the automated sampling, washing, and calibrating of an electrochemical lactate sensor continuously monitoring hepatocyte viability following exposure to the pesticide rotenone. Importantly, integration of an optical sensor allowed us to implement automated optimization protocols that require different computational challenges including: prioritized data structures in a genetic algorithm, distributed computational efforts in multiple-hill climbing searches and real-time realization of probabilistic models in simulated annealing. Our system offers a comprehensive solution for establishing optimization protocols and perfusion sequences in complex microfluidic circuits.

Construction of the Hunveyor-Husar space probe model system for planetary science education and analog studies and simulations in universities and colleges of Hungary.

NASA Astrophysics Data System (ADS)

Bérczi, Sz.; Hegyi, S.; Hudoba, Gy.; Hargitai, H.; Kokiny, A.; Drommer, B.; Gucsik, A.; Pintér, A.; Kovács, Zs.

Several teachers and students had the possibility to visit International Space Camp in the vicinity of the MSFC NASA in Huntsville Alabama USA where they learned the success of simulators in space science education To apply these results in universities and colleges in Hungary we began a unified complex modelling in planetary geology robotics electronics and complex environmental analysis by constructing an experimental space probe model system First a university experimental lander HUNVEYOR Hungarian UNiversity surVEYOR then a rover named HUSAR Hungarian University Surface Analyser Rover has been built For Hunveyor the idea and example was the historical Surveyor program of NASA in the 1960-ies for the Husar the idea and example was the Pathfinder s rover Sojouner rover The first step was the construction of the lander a year later the rover followed The main goals are 1 to build the lander structure and basic electronics from cheap everyday PC compatible elements 2 to construct basic experiments and their instruments 3 to use the system as a space activity simulator 4 this simulator contains lander with on board computer for works on a test planetary surface and a terrestrial control computer 5 to harmonize the assemblage of the electronic system and instruments in various levels of autonomy from the power and communication circuits 6 to use the complex system in education for in situ understanding complex planetary environmental problems 7 to build various planetary environments for application of the

Computer modelling as a tool for the exposure assessment of operators using faulty agricultural pesticide spraying equipment.

PubMed

Bańkowski, Robert; Wiadrowska, Bozena; Beresińska, Martyna; Ludwicki, Jan K; Noworyta-Głowacka, Justyna; Godyń, Artur; Doruchowski, Grzegorz; Hołownicki, Ryszard

2013-01-01

Faulty but still operating agricultural pesticide sprayers may pose an unacceptable health risk for operators. The computerized models designed to calculate exposure and risk for pesticide sprayers used as an aid in the evaluation and further authorisation of plant protection products may be applied also to assess a health risk for operators when faulty sprayers are used. To evaluate the impact of different exposure scenarios on the health risk for the operators using faulty agricultural spraying equipment by means of computer modelling. The exposure modelling was performed for 15 pesticides (5 insecticides, 7 fungicides and 3 herbicides). The critical parameter, i.e. toxicological end-point, on which the risk assessment was based was the no observable adverse effect level (NOAEL). This enabled risk to be estimated under various exposure conditions such as pesticide concentration in the plant protection product and type of the sprayed crop as well as the number of treatments. Computer modelling was based on the UK POEM model including determination of the acceptable operator exposure level (AOEL). Thus the degree of operator exposure could be defined during pesticide treatment whether or not personal protection equipment had been employed by individuals. Data used for computer modelling was obtained from simulated, pesticide substitute treatments using variously damaged knapsack sprayers. These substitute preparations consisted of markers that allowed computer simulations to be made, analogous to real-life exposure situations, in a dose dependent fashion. Exposures were estimated according to operator dosimetry exposure under 'field' conditions for low level, medium and high target field crops. The exposure modelling in the high target field crops demonstrated exceedance of the AOEL in all simulated treatment cases (100%) using damaged sprayers irrespective of the type of damage or if individual protective measures had been adopted or not. For low level and medium field crops exceedances ranged between 40 - 80% cases. The computer modelling may be considered as an practical tool for the hazard assessment when the faulty agricultural sprayers are used. It also may be applied for programming the quality checks and maintenance systems of this equipment.

On simulated annealing phase transitions in phylogeny reconstruction.

PubMed

Strobl, Maximilian A R; Barker, Daniel

2016-08-01

Phylogeny reconstruction with global criteria is NP-complete or NP-hard, hence in general requires a heuristic search. We investigate the powerful, physically inspired, general-purpose heuristic simulated annealing, applied to phylogeny reconstruction. Simulated annealing mimics the physical process of annealing, where a liquid is gently cooled to form a crystal. During the search, periods of elevated specific heat occur, analogous to physical phase transitions. These simulated annealing phase transitions play a crucial role in the outcome of the search. Nevertheless, they have received comparably little attention, for phylogeny or other optimisation problems. We analyse simulated annealing phase transitions during searches for the optimal phylogenetic tree for 34 real-world multiple alignments. In the same way in which melting temperatures differ between materials, we observe distinct specific heat profiles for each input file. We propose this reflects differences in the search landscape and can serve as a measure for problem difficulty and for suitability of the algorithm's parameters. We discuss application in algorithmic optimisation and as a diagnostic to assess parameterisation before computationally costly, large phylogeny reconstructions are launched. Whilst the focus here lies on phylogeny reconstruction under maximum parsimony, it is plausible that our results are more widely applicable to optimisation procedures in science and industry. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Neuromorphic infrared focal plane performs sensor fusion on-plane local-contrast-enhancement spatial and temporal filtering

NASA Astrophysics Data System (ADS)

Massie, Mark A.; Woolaway, James T., II; Curzan, Jon P.; McCarley, Paul L.

1993-08-01

An infrared focal plane has been simulated, designed and fabricated which mimics the form and function of the vertebrate retina. The `Neuromorphic' focal plane has the capability of performing pixel-based sensor fusion and real-time local contrast enhancement, much like the response of the human eye. The device makes use of an indium antimonide detector array with a 3 - 5 micrometers spectral response, and a switched capacitor resistive network to compute a real-time 2D spatial average. This device permits the summation of other sensor outputs to be combined on-chip with the infrared detections of the focal plane itself. The resulting real-time analog processed information thus represents the combined information of many sensors with the advantage that analog spatial and temporal signal processing is performed at the focal plane. A Gaussian subtraction method is used to produce the pixel output which when displayed produces an image with enhanced edges, representing spatial and temporal derivatives in the scene. The spatial and temporal responses of the device are tunable during operation, permitting the operator to `peak up' the response of the array to spatial and temporally varying signals. Such an array adapts to ambient illumination conditions without loss of detection performance. This paper reviews the Neuromorphic infrared focal plane from initial operational simulations to detailed design characteristics, and concludes with a presentation of preliminary operational data for the device as well as videotaped imagery.

Architecture of a mixed-mode electrophysiological signal acquisition interface.

PubMed

Shen, Ding-Lan; Chen, Jyun-Min

2012-01-01

This paper proposes mixed-mode architecture for the acquisition interface of electrophysiological signals. The architecture advances the analog-to-digital converter (ADC) from the second chopper signal in the conventional approach and performs the second chopper operation in the digital domain. The demanded low-pass filter (LPF) is realized with a digital type. The analog LPF in feedback path is substituted with a digital one accompanying with a digital-to-analog converter (DAC). The analog variation is decreased due to the digitization of these operations. The entire architecture is simulated with the ECG input in a behavior model of Simulink.

Optical information processing at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Reid, Max B.; Bualat, Maria G.; Cho, Young C.; Downie, John D.; Gary, Charles K.; Ma, Paul W.; Ozcan, Meric; Pryor, Anna H.; Spirkovska, Lilly

1993-01-01

The combination of analog optical processors with digital electronic systems offers the potential of tera-OPS computational performance, while often requiring less power and weight relative to all-digital systems. NASA is working to develop and demonstrate optical processing techniques for on-board, real time science and mission applications. Current research areas and applications under investigation include optical matrix processing for space structure vibration control and the analysis of Space Shuttle Main Engine plume spectra, optical correlation-based autonomous vision for robotic vehicles, analog computation for robotic path planning, free-space optical interconnections for information transfer within digital electronic computers, and multiplexed arrays of fiber optic interferometric sensors for acoustic and vibration measurements.

Diamond turning machine controller implementation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garrard, K.P.; Taylor, L.W.; Knight, B.F.

The standard controller for a Pnuemo ASG 2500 Diamond Turning Machine, an Allen Bradley 8200, has been replaced with a custom high-performance design. This controller consists of four major components. Axis position feedback information is provided by a Zygo Axiom 2/20 laser interferometer with 0.1 micro-inch resolution. Hardware interface logic couples the computers digital and analog I/O channels to the diamond turning machine`s analog motor controllers, the laser interferometer, and other machine status and control information. It also provides front panel switches for operator override of the computer controller and implement the emergency stop sequence. The remaining two components, themore » control computer hardware and software, are discussed in detail below.« less

Normal Component of Induced Velocity for Entire Field of a Uniformly Loaded Lifting Rotor with Highly Swept Wake as Determined by Electromagnetic Analog

NASA Technical Reports Server (NTRS)

Castles, Walter, Jr.; Durham, Howard L., Jr.; Kevorkian, Jirair

1959-01-01

Values of the normal component of induced velocity throughout the entire field of a uniformly loaded r(rotor at high high speed are presented in the form of charts and tables. Many points were found by an electromagnetic analog, details of which are given. Comparisons of computed and analog values for the induced velocity indicate that the latter are sufficiently accurate for engineering purposes.

Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations for solvent-based carbon capture. Part 2: Chemical absorption across a wetted wall column: Original Research Article: Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Chao; Xu, Zhijie; Lai, Kevin

The first part of this paper (Part 1) presents a numerical model for non-reactive physical mass transfer across a wetted wall column (WWC). In Part 2, we improved the existing computational fluid dynamics (CFD) model to simulate chemical absorption occurring in a WWC as a bench-scale study of solvent-based carbon dioxide (CO2) capture. To generate data for WWC model validation, CO2 mass transfer across a monoethanolamine (MEA) solvent was first measured on a WWC experimental apparatus. The numerical model developed in this work has the ability to account for both chemical absorption and desorption of CO2 in MEA. In addition,more » the overall mass transfer coefficient predicted using traditional/empirical correlations is conducted and compared with CFD prediction results for both steady and wavy falling films. A Bayesian statistical calibration algorithm is adopted to calibrate the reaction rate constants in chemical absorption/desorption of CO2 across a falling film of MEA. The posterior distributions of the two transport properties, i.e., Henry’s constant and gas diffusivity in the non-reacting nitrous oxide (N2O)/MEA system obtained from Part 1 of this study, serves as priors for the calibration of CO2 reaction rate constants after using the N2O/CO2 analogy method. The calibrated model can be used to predict the CO2 mass transfer in a WWC for a wider range of operating conditions.« less

Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations for solvent-based carbon capture. Part 2: Chemical absorption across a wetted wall column: Original Research Article: Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Chao; Xu, Zhijie; Lai, Kevin

Part 1 of this paper presents a numerical model for non-reactive physical mass transfer across a wetted wall column (WWC). In Part 2, we improved the existing computational fluid dynamics (CFD) model to simulate chemical absorption occurring in a WWC as a bench-scale study of solvent-based carbon dioxide (CO 2) capture. In this study, to generate data for WWC model validation, CO 2 mass transfer across a monoethanolamine (MEA) solvent was first measured on a WWC experimental apparatus. The numerical model developed in this work can account for both chemical absorption and desorption of CO 2 in MEA. In addition,more » the overall mass transfer coefficient predicted using traditional/empirical correlations is conducted and compared with CFD prediction results for both steady and wavy falling films. A Bayesian statistical calibration algorithm is adopted to calibrate the reaction rate constants in chemical absorption/desorption of CO 2 across a falling film of MEA. The posterior distributions of the two transport properties, i.e., Henry's constant and gas diffusivity in the non-reacting nitrous oxide (N 2O)/MEA system obtained from Part 1 of this study, serves as priors for the calibration of CO 2 reaction rate constants after using the N 2O/CO 2 analogy method. Finally, the calibrated model can be used to predict the CO 2 mass transfer in a WWC for a wider range of operating conditions.« less

Computational discovery of metal-organic frameworks with high gas deliverable capacity

NASA Astrophysics Data System (ADS)

Bao, Yi

Metal-organic frameworks (MOFs) are a rapidly emerging class of nanoporous materials with largely tunable chemistry and diverse applications in gas storage, gas purification, catalysis, sensing and drug delivery. Efforts have been made to develop new MOFs with desirable properties both experimentally and computationally for decades. To guide experimental synthesis, we here develop a computational methodology to explore MOFs with high gas deliverable capacity. This de novo design procedure applies known chemical reactions, considers synthesizability and geometric requirements of organic linkers, and efficiently evolves a population of MOFs to optimize a desirable property. We identify 48 MOFs with higher methane deliverable capacity at 65-5.8 bar condition than the MOF-5 reference in nine networks. In a more comprehensive work, we predict two sets of MOFs with high methane deliverable capacity at a 65-5.8 bar loading-delivery condition or a 35-5.8 bar loading-delivery condition. We also optimize a set of MOFs with high methane accessible internal surface area to investigate the relationship between deliverable capacities and internal surface area. This methodology can be extended to MOFs with multiple types of linkers and multiple SBUs. Flexibile MOFs may allow for sophisticated heat management strategies and also provide higher gas deliverable capacity than rigid frameworks. We investigate flexible MOFs, such as MIL-53 families, and Fe(bdp) and Co(bdp) analogs, to understand the structural phase transition of frameworks and the resulting influence on heat of adsorption. Challenges of simulating a system with a flexible host structure and incoming guest molecules are discussed. Preliminary results from isotherm simulation using the hybrid MC/MD simulation scheme on MIL-53(Cr) are presented. Suggestions for proceeding to understand the free energy profile of flexible MOFs are provided.

Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations for solvent-based carbon capture. Part 2: Chemical absorption across a wetted wall column: Original Research Article: Hierarchical calibration and validation framework of bench-scale computational fluid dynamics simulations

DOE PAGES

Wang, Chao; Xu, Zhijie; Lai, Kevin; ...

2017-10-24

Part 1 of this paper presents a numerical model for non-reactive physical mass transfer across a wetted wall column (WWC). In Part 2, we improved the existing computational fluid dynamics (CFD) model to simulate chemical absorption occurring in a WWC as a bench-scale study of solvent-based carbon dioxide (CO 2) capture. In this study, to generate data for WWC model validation, CO 2 mass transfer across a monoethanolamine (MEA) solvent was first measured on a WWC experimental apparatus. The numerical model developed in this work can account for both chemical absorption and desorption of CO 2 in MEA. In addition,more » the overall mass transfer coefficient predicted using traditional/empirical correlations is conducted and compared with CFD prediction results for both steady and wavy falling films. A Bayesian statistical calibration algorithm is adopted to calibrate the reaction rate constants in chemical absorption/desorption of CO 2 across a falling film of MEA. The posterior distributions of the two transport properties, i.e., Henry's constant and gas diffusivity in the non-reacting nitrous oxide (N 2O)/MEA system obtained from Part 1 of this study, serves as priors for the calibration of CO 2 reaction rate constants after using the N 2O/CO 2 analogy method. Finally, the calibrated model can be used to predict the CO 2 mass transfer in a WWC for a wider range of operating conditions.« less

Regional peak mucosal cooling predicts the perception of nasal patency.

PubMed

Zhao, Kai; Jiang, Jianbo; Blacker, Kara; Lyman, Brian; Dalton, Pamela; Cowart, Beverly J; Pribitkin, Edmund A

2014-03-01

Nasal obstruction is the principal symptom that drives patients with rhinosinus disease to seek medical treatment. However, patient perception of obstruction often bears little relationship to actual measured physical obstruction of airflow. This lack of an objective clinical tool hinders effective diagnosis and treatment. Previous work has suggested that the perception of nasal patency may involve nasal trigeminal activation by cool inspiratory airflow; we attempt to derive clinically relevant variables following this phenomenon. Prospective healthy cohort. Twenty-two healthy subjects rated unilateral nasal patency in controlled room air using a visual analog scale, followed by rhinomanometry, acoustic rhinometry, and butanol lateralization thresholds (BLTs). Each subject then immediately underwent a computed tomography scan, enabling the construction of a real-time computational fluid dynamics (CFD) nasal airway model, which was used to simulate nasal mucosa heat loss during steady resting breathing. Among all measured and computed variables, only CFD-simulated peak heat loss posterior to the nasal vestibule significantly correlated with patency ratings (r = -0.46, P < .01). Linear discriminant analysis predicted patency categories with 89% success rate, with BLT and rhinomanometric nasal resistance being two additional significant variables. As validation, CFD simulated nasal resistance significantly correlated with rhinomanometrically measured resistance (r = 0.41, P < .01). These results reveal that our noses are sensing patency via a mechanism involving localized peak nasal mucosal cooling. The analysis provides a strong rationale for combining the individualized CFD with other objective and neurologic measures to create a novel clinical tool to diagnose nasal obstruction and to predict and evaluate treatment outcomes. © 2013 The American Laryngological, Rhinological and Otological Society, Inc.

Analogical Transfer from a Simulated Physical System

ERIC Educational Resources Information Center

Day, Samuel B.; Goldstone, Robert L.

2011-01-01

Previous research has consistently found that spontaneous analogical transfer is strongly tied to concrete and contextual similarities between the cases. However, that work has largely failed to acknowledge that the relevant factor in transfer is the similarity between individuals' mental representations of the situations rather than the overt…

47 CFR 69.157 - Line port costs in excess of basic, analog service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Line port costs in excess of basic, analog service. 69.157 Section 69.157 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) ACCESS CHARGES Computation of Charges for Price Cap Local Exchange Carriers...

Programming Languages, Natural Languages, and Mathematics

ERIC Educational Resources Information Center

Naur, Peter

1975-01-01

Analogies are drawn between the social aspects of programming and similar aspects of mathematics and natural languages. By analogy with the history of auxiliary languages it is suggested that Fortran and Cobol will remain dominant. (Available from the Association of Computing Machinery, 1133 Avenue of the Americas, New York, NY 10036.) (Author/TL)

Contour Detector and Data Acquisition System for the Left Ventricular Outline

NASA Technical Reports Server (NTRS)

Reiber, J. H. C. (Inventor)

1978-01-01

A real-time contour detector and data acquisition system is described for an angiographic apparatus having a video scanner for converting an X-ray image of a structure characterized by a change in brightness level compared with its surrounding into video format and displaying the X-ray image in recurring video fields. The real-time contour detector and data acqusition system includes track and hold circuits; a reference level analog computer circuit; an analog compartor; a digital processor; a field memory; and a computer interface.

Linkage mechanisms in the vertebrate skull: Structure and function of three-dimensional, parallel transmission systems.

PubMed

Olsen, Aaron M; Westneat, Mark W

2016-12-01

Many musculoskeletal systems, including the skulls of birds, fishes, and some lizards consist of interconnected chains of mobile skeletal elements, analogous to linkage mechanisms used in engineering. Biomechanical studies have applied linkage models to a diversity of musculoskeletal systems, with previous applications primarily focusing on two-dimensional linkage geometries, bilaterally symmetrical pairs of planar linkages, or single four-bar linkages. Here, we present new, three-dimensional (3D), parallel linkage models of the skulls of birds and fishes and use these models (available as free kinematic simulation software), to investigate structure-function relationships in these systems. This new computational framework provides an accessible and integrated workflow for exploring the evolution of structure and function in complex musculoskeletal systems. Linkage simulations show that kinematic transmission, although a suitable functional metric for linkages with single rotating input and output links, can give misleading results when applied to linkages with substantial translational components or multiple output links. To take into account both linear and rotational displacement we define force mechanical advantage for a linkage (analogous to lever mechanical advantage) and apply this metric to measure transmission efficiency in the bird cranial mechanism. For linkages with multiple, expanding output points we propose a new functional metric, expansion advantage, to measure expansion amplification and apply this metric to the buccal expansion mechanism in fishes. Using the bird cranial linkage model, we quantify the inaccuracies that result from simplifying a 3D geometry into two dimensions. We also show that by combining single-chain linkages into parallel linkages, more links can be simulated while decreasing or maintaining the same number of input parameters. This generalized framework for linkage simulation and analysis can accommodate linkages of differing geometries and configurations, enabling novel interpretations of the mechanics of force transmission across a diversity of vertebrate feeding mechanisms and enhancing our understanding of musculoskeletal function and evolution. J. Morphol. 277:1570-1583, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Comanche Helmet-Mounted Display Symbology Simulation

NASA Technical Reports Server (NTRS)

Turpin, Terry S.; Dowell, Susan R.; Szoboszlay, Zoltan

2006-01-01

The Aeroflightdynamics Directorate (AMRDEC) conducted a simulation to examine the performance of the Comanche Contact Analog world-referenced symbology displayed on the Comanche HIDSS when compared with a compressed symbology design similar to that specified by the former MIL-STD 1295. Six experimental test pilots flew one modified ADS-33 maneuver (hover turn, bob-up), an unusual attitude recovery, and two terrain flight tactical tasks in the NASA Vertical Motion Simulator (VMS). Analysis of the pilot objective performance data and subjective data showed the following results. Objective test results showed that 1295 symbology yielded more rapid maneuvering in the hover turn bob-up than Contact Analog symbology. The average margin of difference in the time to complete the maneuver was approximately two seconds, which was statistically significant. There were no significant differences measured between symbology sets with respect to altitude or position performance measures for all other maneuvers. The NOE target ID task data showed improved accuracy in determining heading to target when using Contact Analog over MIL-STD-1295. Subjective test results, including handling qualities ratings (HQRs) and NASA-TLX workload ratings, showed small but consistent advantages of 1295 symbology over Contact Analog for most parameters. For the bob-up maneuver, 1295 symbology handling qualities were rated Desired for lateral position error and time to complete whereas Contact Analog was rated adequate. The average HQRs for all other maneuvers were rated the same for both symbology sets. Pilot comments and the results of an online questionnaire more strongly favored 1295 over Contact Analog. Repeated comments from all six pilots led to a focus on design issues with six Contact Analog symbols. Those symbols were the heading tape, horizon line, radar altitude six-second predictor, the position of the torque symbol, the absence of a hover position cue, and the widespread positioning of the symbology to the outer edges of the display field-of-view. Pilots rated the present design of three of the six symbols as having safety-of-flight implications. Those symbols were the heading tape, horizon line, and six-second predictor. To summarize, test results showed no objective data that would warrant restricting experimental test pilots from flying constrained tasks. Small but consistent advantages were recorded for the MILSTD-1295 symbology design when executing ADS-33 constrained tasks. No general performance differences were recorded for the operational maneuvers (NOE, contour flight modes) except for the azimuth-to-target task, which favored the Contact Analog heading tape design. There were consistent and strong pilot comments supporting the MIL-STD-1295 design over Contact Analog in both this current simulation and in Comanche Sim I. Three Contact Analog symbols warrant modification and further evaluation to mitigate safety-of-flight implications noted by participating test pilots. A plan for symbology redesign and testing was developed. However, the Comanche program was cancelled by Department of Army in February 2004.

Suited versus unsuited analog astronaut performance using the Aouda.X space suit simulator: the DELTA experiment of MARS2013.

PubMed

Soucek, Alexander; Ostkamp, Lutz; Paternesi, Roberta

2015-04-01

Space suit simulators are used for extravehicular activities (EVAs) during Mars analog missions. Flight planning and EVA productivity require accurate time estimates of activities to be performed with such simulators, such as experiment execution or traverse walking. We present a benchmarking methodology for the Aouda.X space suit simulator of the Austrian Space Forum. By measuring and comparing the times needed to perform a set of 10 test activities with and without Aouda.X, an average time delay was derived in the form of a multiplicative factor. This statistical value (a second-over-second time ratio) is 1.30 and shows that operations in Aouda.X take on average a third longer than the same operations without the suit. We also show that activities predominantly requiring fine motor skills are associated with larger time delays (between 1.17 and 1.59) than those requiring short-distance locomotion or short-term muscle strain (between 1.10 and 1.16). The results of the DELTA experiment performed during the MARS2013 field mission increase analog mission planning reliability and thus EVA efficiency and productivity when using Aouda.X.

Searching for Organics During the Robotic Mars Analog Rio Tinto Drilling Experiment: Ground Truth and Contamination Issues

NASA Astrophysics Data System (ADS)

Bonaccorsi, R.; Stoker, C. R.; Marte Project Science Team

2007-03-01

The Mars Analog Rio Tinto Experiment (MARTE) performed a simulation of a Mars drilling experiment at the Rio Tinto (Spain). Ground-truth and contamination issues during the distribution of bulk organics and their CN isotopic composition in hematite and go

The Search for Subsurface Life on Mars: Results from the MARTE Analog Drill Experiment in Rio Tinto, Spain

NASA Astrophysics Data System (ADS)

Stoker, C. R.; Lemke, L. G.; Cannon, H.; Glass, B.; Dunagan, S.; Zavaleta, J.; Miller, D.; Gomez-Elvira, J.

2006-03-01

The Mars Analog Research and Technology (MARTE) experiment has developed an automated drilling system on a simulated Mars lander platform including drilling, sample handling, core analysis and down-hole instruments relevant to searching for life in the Martian subsurface.

The Structure-Mapping Engine: Algorithm and Examples.

ERIC Educational Resources Information Center

Falkenhainer, Brian; And Others

This description of the Structure-Mapping Engine (SME), a flexible, cognitive simulation program for studying analogical processing which is based on Gentner's Structure-Mapping theory of analogy, points out that the SME provides a "tool kit" for constructing matching algorithms consistent with this theory. This report provides: (1) a…

Biotoxicity of Mars Analog Soils: Microbial Dispersal into Desiccated Soils Versus Emplacement in Salt or Ice Inclusion Fluids

NASA Astrophysics Data System (ADS)

Schuerger, A. C.; Ming, D. W.; Golden, D. C.

2010-04-01

Six Mars analog soils were prepared to simulate a range of potentially biotoxic soils. Interactive effects of high-salt, desiccation, and low pressure were responsible for significant decreases in viable numbers of microbial species tested under martian conditions for 7 d.

Hybrid Computation at Louisiana State University.

ERIC Educational Resources Information Center

Corripio, Armando B.

Hybrid computation facilities have been in operation at Louisiana State University since the spring of 1969. In part, they consist of an Electronics Associates, Inc. (EAI) Model 680 analog computer, an EAI Model 693 interface, and a Xerox Data Systems (XDS) Sigma 5 digital computer. The hybrid laboratory is used in a course on hybrid computation…

Computational Intelligence and Wavelet Transform Based Metamodel for Efficient Generation of Not-Yet Simulated Waveforms.

PubMed

Oltean, Gabriel; Ivanciu, Laura-Nicoleta

2016-01-01

The design and verification of complex electronic systems, especially the analog and mixed-signal ones, prove to be extremely time consuming tasks, if only circuit-level simulations are involved. A significant amount of time can be saved if a cost effective solution is used for the extensive analysis of the system, under all conceivable conditions. This paper proposes a data-driven method to build fast to evaluate, but also accurate metamodels capable of generating not-yet simulated waveforms as a function of different combinations of the parameters of the system. The necessary data are obtained by early-stage simulation of an electronic control system from the automotive industry. The metamodel development is based on three key elements: a wavelet transform for waveform characterization, a genetic algorithm optimization to detect the optimal wavelet transform and to identify the most relevant decomposition coefficients, and an artificial neuronal network to derive the relevant coefficients of the wavelet transform for any new parameters combination. The resulted metamodels for three different waveform families are fully reliable. They satisfy the required key points: high accuracy (a maximum mean squared error of 7.1x10-5 for the unity-based normalized waveforms), efficiency (fully affordable computational effort for metamodel build-up: maximum 18 minutes on a general purpose computer), and simplicity (less than 1 second for running the metamodel, the user only provides the parameters combination). The metamodels can be used for very efficient generation of new waveforms, for any possible combination of dependent parameters, offering the possibility to explore the entire design space. A wide range of possibilities becomes achievable for the user, such as: all design corners can be analyzed, possible worst-case situations can be investigated, extreme values of waveforms can be discovered, sensitivity analyses can be performed (the influence of each parameter on the output waveform).

Computational Intelligence and Wavelet Transform Based Metamodel for Efficient Generation of Not-Yet Simulated Waveforms

PubMed Central

Oltean, Gabriel; Ivanciu, Laura-Nicoleta

2016-01-01

The design and verification of complex electronic systems, especially the analog and mixed-signal ones, prove to be extremely time consuming tasks, if only circuit-level simulations are involved. A significant amount of time can be saved if a cost effective solution is used for the extensive analysis of the system, under all conceivable conditions. This paper proposes a data-driven method to build fast to evaluate, but also accurate metamodels capable of generating not-yet simulated waveforms as a function of different combinations of the parameters of the system. The necessary data are obtained by early-stage simulation of an electronic control system from the automotive industry. The metamodel development is based on three key elements: a wavelet transform for waveform characterization, a genetic algorithm optimization to detect the optimal wavelet transform and to identify the most relevant decomposition coefficients, and an artificial neuronal network to derive the relevant coefficients of the wavelet transform for any new parameters combination. The resulted metamodels for three different waveform families are fully reliable. They satisfy the required key points: high accuracy (a maximum mean squared error of 7.1x10-5 for the unity-based normalized waveforms), efficiency (fully affordable computational effort for metamodel build-up: maximum 18 minutes on a general purpose computer), and simplicity (less than 1 second for running the metamodel, the user only provides the parameters combination). The metamodels can be used for very efficient generation of new waveforms, for any possible combination of dependent parameters, offering the possibility to explore the entire design space. A wide range of possibilities becomes achievable for the user, such as: all design corners can be analyzed, possible worst-case situations can be investigated, extreme values of waveforms can be discovered, sensitivity analyses can be performed (the influence of each parameter on the output waveform). PMID:26745370

Adsorption of flexible polymer chains on a surface: Effects of different solvent conditions

NASA Astrophysics Data System (ADS)

Martins, P. H. L.; Plascak, J. A.; Bachmann, M.

2018-05-01

Polymer chains undergoing a continuous adsorption-desorption transition are studied through extensive computer simulations. A three-dimensional self-avoiding walk lattice model of a polymer chain grafted onto a surface has been treated for different solvent conditions. We have used an advanced contact-density chain-growth algorithm, in which the density of contacts can be directly obtained. From this quantity, the order parameter and its fourth-order Binder cumulant are computed, as well as the corresponding critical exponents and the adsorption-desorption transition temperature. As the number of configurations with a given number of surface contacts and monomer-monomer contacts is independent of the temperature and solvent conditions, it can be easily applied to get results for different solvent parameter values without the need of any extra simulations. In analogy to continuous magnetic phase transitions, finite-size-scaling methods have been employed. Quite good results for the critical properties and phase diagram of very long single polymer chains have been obtained by properly taking into account the effects of corrections to scaling. The study covers all solvent effects, going from the limit of super-self-avoiding walks, characterized by effective monomer-monomer repulsion, to poor solvent conditions that enable the formation of compact polymer structures.

Fluid management technology: Liquid slosh dynamics and control

NASA Technical Reports Server (NTRS)

Dodge, Franklin T.; Green, Steven T.; Kana, Daniel D.

1991-01-01

Flight experiments were defined for the Cryogenic On-Orbit Liquid Depot Storage, Acquisition and Transfer Satellite (COLD-SAT) test bed satellite and the Shuttle middeck to help establish the influence of the gravitational environment on liquid slosh dynamics and control. Several analytical and experimental studies were also conducted to support the experiments and to help understand the anticipated results. Both FLOW-3D and NASA-VOF3D computer codes were utilized to simulate low Bond number, small amplitude sloshing, for which the motions are dominated by surface forces; it was found that neither code provided a satisfactory simulation. Thus, a new analysis of low Bond number sloshing was formulated, using an integral minimization technique that will allow the assumptions made about surface physics phenomena to be modified easily when better knowledge becomes available from flight experiments. Several examples were computed by the innovative use of a finite-element structural code. An existing spherical-pendulum analogy of nonlinear, rotary sloshing was also modified for easier use and extended to low-gravity conditions. Laboratory experiments were conducted to determine the requirements for liquid-vapor interface sensors as a method of resolving liquid surface motions in flight experiments. The feasibility of measuring the small slosh forces anticipated in flight experiments was also investigated.

Fluid management technology: Liquid slosh dynamics and control

NASA Astrophysics Data System (ADS)

Dodge, Franklin T.; Green, Steven T.; Kana, Daniel D.

1991-11-01

Flight experiments were defined for the Cryogenic On-Orbit Liquid Depot Storage, Acquisition and Transfer Satellite (COLD-SAT) test bed satellite and the Shuttle middeck to help establish the influence of the gravitational environment on liquid slosh dynamics and control. Several analytical and experimental studies were also conducted to support the experiments and to help understand the anticipated results. Both FLOW-3D and NASA-VOF3D computer codes were utilized to simulate low Bond number, small amplitude sloshing, for which the motions are dominated by surface forces; it was found that neither code provided a satisfactory simulation. Thus, a new analysis of low Bond number sloshing was formulated, using an integral minimization technique that will allow the assumptions made about surface physics phenomena to be modified easily when better knowledge becomes available from flight experiments. Several examples were computed by the innovative use of a finite-element structural code. An existing spherical-pendulum analogy of nonlinear, rotary sloshing was also modified for easier use and extended to low-gravity conditions. Laboratory experiments were conducted to determine the requirements for liquid-vapor interface sensors as a method of resolving liquid surface motions in flight experiments. The feasibility of measuring the small slosh forces anticipated in flight experiments was also investigated.

Zero-crossing sampling of Fourier-transform interferograms and spectrum reconstruction using the real-zero interpolation method.

PubMed

Minami, K; Kawata, S; Minami, S

1992-10-10

The real-zero interpolation method is applied to a Fourier-transformed infrared (FT-IR) interferogram. With this method an interferogram is reconstructed from its zero-crossing information only, without the use of a long-word analog-to-digital converter. We installed a phase-locked loop circuit into an FT-IR spectrometer for oversampling the interferogram. Infrared absorption spectra of polystyrene and Mylar films were measured as binary interferograms by the FT-IR spectrometer, which was equipped with the developed circuits, and their Fourier spectra were successfully reconstructed. The relationship of the oversampling ratio to the dynamic range of the reconstructed interferogram was evaluated through computer simulations. We also discuss the problems of this method for practical applications.

Effects of low sampling rate in the digital data-transition tracking loop

NASA Technical Reports Server (NTRS)

Mileant, A.; Million, S.; Hinedi, S.

1994-01-01

This article describes the performance of the all-digital data-transition tracking loop (DTTL) with coherent and noncoherent sampling using nonlinear theory. The effects of few samples per symbol and of noncommensurate sampling and symbol rates are addressed and analyzed. Their impact on the probability density and variance of the phase error are quantified through computer simulations. It is shown that the performance of the all-digital DTTL approaches its analog counterpart when the sampling and symbol rates are noncommensurate (i.e., the number of samples per symbol is an irrational number). The loop signal-to-noise ratio (SNR) (inverse of phase error variance) degrades when the number of samples per symbol is an odd integer but degrades even further for even integers.

A newly developed spinal simulator.

PubMed

Chester, R; Watson, M J

2000-11-01

A number of studies indicate poor intra-therapist and inter-therapist reliability in the performance of graded, passive oscillatory movements to the lumbar spine. However, it has been suggested that therapists can be trained to be more consistent in their performance of these techniques if given reliable quantitative feedback. The intention of this study was to develop equipment, analogous to the lumbar spine that could be used for both teaching and research purposes. Equipment has been updated and connected to a personal IBM compatible computer. Custom designed software allows concurrent and accurate feedback to students on their performance and in a form suitable for advanced data analysis using statistical packages. The uses and implications of this equipment are discussed. Copyright 2000 Harcourt Publishers Ltd.

Numerical relativity beyond astrophysics.

PubMed

Garfinkle, David

2017-01-01

Though the main applications of computer simulations in relativity are to astrophysical systems such as black holes and neutron stars, nonetheless there are important applications of numerical methods to the investigation of general relativity as a fundamental theory of the nature of space and time. This paper gives an overview of some of these applications. In particular we cover (i) investigations of the properties of spacetime singularities such as those that occur in the interior of black holes and in big bang cosmology. (ii) investigations of critical behavior at the threshold of black hole formation in gravitational collapse. (iii) investigations inspired by string theory, in particular analogs of black holes in more than 4 spacetime dimensions and gravitational collapse in spacetimes with a negative cosmological constant.

Surface wave and linear operating mode of a plasma antenna

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bogachev, N. N., E-mail: bgniknik@yandex.ru; Bogdankevich, I. L.; Gusein-zade, N. G.

The relation between the propagation conditions of a surface electromagnetic wave along a finiteradius plasma cylinder and the linear operating mode of a plasma antenna is investigated. The solution to the dispersion relation for a surface wave propagating along a finite-radius plasma cylinder is analyzed for weakly and strongly collisional plasmas. Computer simulations of an asymmetrical plasma dipole antenna are performed using the KARAT code, wherein the dielectric properties of plasma are described in terms of the Drude model. The plasma parameters corresponding to the linear operating mode of a plasma antenna are determined. It is demonstrated that the characteristicsmore » of the plasma antenna in this mode are close to those of an analogous metal antenna.« less

Numerical relativity beyond astrophysics

NASA Astrophysics Data System (ADS)

Garfinkle, David

2017-01-01

Though the main applications of computer simulations in relativity are to astrophysical systems such as black holes and neutron stars, nonetheless there are important applications of numerical methods to the investigation of general relativity as a fundamental theory of the nature of space and time. This paper gives an overview of some of these applications. In particular we cover (i) investigations of the properties of spacetime singularities such as those that occur in the interior of black holes and in big bang cosmology. (ii) investigations of critical behavior at the threshold of black hole formation in gravitational collapse. (iii) investigations inspired by string theory, in particular analogs of black holes in more than 4 spacetime dimensions and gravitational collapse in spacetimes with a negative cosmological constant.

3D RISM theory with fast reciprocal-space electrostatics.

PubMed

Heil, Jochen; Kast, Stefan M

2015-03-21

The calculation of electrostatic solute-solvent interactions in 3D RISM ("three-dimensional reference interaction site model") integral equation theory is recast in a form that allows for a computational treatment analogous to the "particle-mesh Ewald" formalism as used for molecular simulations. In addition, relations that connect 3D RISM correlation functions and interaction potentials with thermodynamic quantities such as the chemical potential and average solute-solvent interaction energy are reformulated in a way that calculations of expensive real-space electrostatic terms on the 3D grid are completely avoided. These methodical enhancements allow for both, a significant speedup particularly for large solute systems and a smoother convergence of predicted thermodynamic quantities with respect to box size, as illustrated for several benchmark systems.

LS-DYNA Implementation of Polymer Matrix Composite Model Under High Strain Rate Impact

NASA Technical Reports Server (NTRS)

Zheng, Xia-Hua; Goldberg, Robert K.; Binienda, Wieslaw K.; Roberts, Gary D.

2003-01-01

A recently developed constitutive model is implemented into LS-DYNA as a user defined material model (UMAT) to characterize the nonlinear strain rate dependent behavior of polymers. By utilizing this model within a micromechanics technique based on a laminate analogy, an algorithm to analyze the strain rate dependent, nonlinear deformation of a fiber reinforced polymer matrix composite is then developed as a UMAT to simulate the response of these composites under high strain rate impact. The models are designed for shell elements in order to ensure computational efficiency. Experimental and numerical stress-strain curves are compared for two representative polymers and a representative polymer matrix composite, with the analytical model predicting the experimental response reasonably well.

Modeling the behavioral substrates of associate learning and memory - Adaptive neural models

NASA Technical Reports Server (NTRS)

Lee, Chuen-Chien

1991-01-01

Three adaptive single-neuron models based on neural analogies of behavior modification episodes are proposed, which attempt to bridge the gap between psychology and neurophysiology. The proposed models capture the predictive nature of Pavlovian conditioning, which is essential to the theory of adaptive/learning systems. The models learn to anticipate the occurrence of a conditioned response before the presence of a reinforcing stimulus when training is complete. Furthermore, each model can find the most nonredundant and earliest predictor of reinforcement. The behavior of the models accounts for several aspects of basic animal learning phenomena in Pavlovian conditioning beyond previous related models. Computer simulations show how well the models fit empirical data from various animal learning paradigms.

The Computer Bulletin Board.

ERIC Educational Resources Information Center

Batt, Russell H., Ed.

1989-01-01

Discussed are some uses of computers in chemistry classrooms. Described are: (1) interactive chromatographic analysis software; (2) computer interface for a digital frequency-period-counter-ratio meter and analog interface based on a voltage-to-frequency converter; and (3) use of spectrometer/microcomputer arrangement for teaching atomic theory.…

Theoretical foundations of the sound analog membrane potential that underlies coincidence detection in the barn owl

PubMed Central

Ashida, Go; Funabiki, Kazuo; Carr, Catherine E.

2013-01-01

A wide variety of neurons encode temporal information via phase-locked spikes. In the avian auditory brainstem, neurons in the cochlear nucleus magnocellularis (NM) send phase-locked synaptic inputs to coincidence detector neurons in the nucleus laminaris (NL) that mediate sound localization. Previous modeling studies suggested that converging phase-locked synaptic inputs may give rise to a periodic oscillation in the membrane potential of their target neuron. Recent physiological recordings in vivo revealed that owl NL neurons changed their spike rates almost linearly with the amplitude of this oscillatory potential. The oscillatory potential was termed the sound analog potential, because of its resemblance to the waveform of the stimulus tone. The amplitude of the sound analog potential recorded in NL varied systematically with the interaural time difference (ITD), which is one of the most important cues for sound localization. In order to investigate the mechanisms underlying ITD computation in the NM-NL circuit, we provide detailed theoretical descriptions of how phase-locked inputs form oscillating membrane potentials. We derive analytical expressions that relate presynaptic, synaptic, and postsynaptic factors to the signal and noise components of the oscillation in both the synaptic conductance and the membrane potential. Numerical simulations demonstrate the validity of the theoretical formulations for the entire frequency ranges tested (1–8 kHz) and potential effects of higher harmonics on NL neurons with low best frequencies (<2 kHz). PMID:24265616

ANALOG-TO-DIGITAL DATA CONVERTER

DOEpatents

Rodgers, G.W.; Althouse, J.E.; Anderson, D.P.; Bussey, G.R.; Minnear, L.H.

1960-09-01

Electrical apparatus is described, particularly useful in telemetry work, for converting analog signals into electrical pulses and recording them. An electronic editor commands the taking of signal readings at a frequency which varies according to linearity of the analog signal being converted. Readings of information signals are recorded, along with time base readings and serial numbering, if desired, on magnetic tape and the latter may be used to operate a computer or the like. Magnetic tape data may be transferred to punched cards.

Efficient dynamical correction of the transition state theory rate estimate for a flat energy barrier.

PubMed

Mökkönen, Harri; Ala-Nissila, Tapio; Jónsson, Hannes

2016-09-07

The recrossing correction to the transition state theory estimate of a thermal rate can be difficult to calculate when the energy barrier is flat. This problem arises, for example, in polymer escape if the polymer is long enough to stretch between the initial and final state energy wells while the polymer beads undergo diffusive motion back and forth over the barrier. We present an efficient method for evaluating the correction factor by constructing a sequence of hyperplanes starting at the transition state and calculating the probability that the system advances from one hyperplane to another towards the product. This is analogous to what is done in forward flux sampling except that there the hyperplane sequence starts at the initial state. The method is applied to the escape of polymers with up to 64 beads from a potential well. For high temperature, the results are compared with direct Langevin dynamics simulations as well as forward flux sampling and excellent agreement between the three rate estimates is found. The use of a sequence of hyperplanes in the evaluation of the recrossing correction speeds up the calculation by an order of magnitude as compared with the traditional approach. As the temperature is lowered, the direct Langevin dynamics simulations as well as the forward flux simulations become computationally too demanding, while the harmonic transition state theory estimate corrected for recrossings can be calculated without significant increase in the computational effort.

Where Tori Fear to Tread: Hypermassive Neutron Star Remnants and Absolute Event Horizons or Topics in Computational General Relativity

NASA Astrophysics Data System (ADS)

Kaplan, Jeffrey Daniel

2014-01-01

Computational general relativity is a field of study which has reached maturity only within the last decade. This thesis details several studies that elucidate phenomena related to the coalescence of compact object binaries. Chapters 2 and 3 recounts work towards developing new analytical tools for visualizing and reasoning about dynamics in strongly curved spacetimes. In both studies, the results employ analogies with the classical theory of electricity and magnetism, first (Ch. 2) in the post-Newtonian approximation to general relativity and then (Ch. 3) in full general relativity though in the absence of matter sources. In Chapter 4, we examine the topological structure of absolute event horizons during binary black hole merger simulations conducted with the SpEC code. Chapter 6 reports on the progress of the SpEC code in simulating the coalescence of neutron star-neutron star binaries, while Chapter 7 tests the effects of various numerical gauge conditions on the robustness of black hole formation from stellar collapse in SpEC. In Chapter 5, we examine the nature of pseudospectral expansions of non-smooth functions motivated by the need to simulate the stellar surface in Chapters 6 and 7. In Chapter 8, we study how thermal effects in the nuclear equation of state effect the equilibria and stability of hypermassive neutron stars. Chapter 9 presents supplements to the work in Chapter 8, including an examination of the stability question raised in Chapter 8 in greater mathematical detail.

A reduced basis method for molecular dynamics simulation

NASA Astrophysics Data System (ADS)

Vincent-Finley, Rachel Elisabeth

In this dissertation, we develop a method for molecular simulation based on principal component analysis (PCA) of a molecular dynamics trajectory and least squares approximation of a potential energy function. Molecular dynamics (MD) simulation is a computational tool used to study molecular systems as they evolve through time. With respect to protein dynamics, local motions, such as bond stretching, occur within femtoseconds, while rigid body and large-scale motions, occur within a range of nanoseconds to seconds. To capture motion at all levels, time steps on the order of a femtosecond are employed when solving the equations of motion and simulations must continue long enough to capture the desired large-scale motion. To date, simulations of solvated proteins on the order of nanoseconds have been reported. It is typically the case that simulations of a few nanoseconds do not provide adequate information for the study of large-scale motions. Thus, the development of techniques that allow longer simulation times can advance the study of protein function and dynamics. In this dissertation we use principal component analysis (PCA) to identify the dominant characteristics of an MD trajectory and to represent the coordinates with respect to these characteristics. We augment PCA with an updating scheme based on a reduced representation of a molecule and consider equations of motion with respect to the reduced representation. We apply our method to butane and BPTI and compare the results to standard MD simulations of these molecules. Our results indicate that the molecular activity with respect to our simulation method is analogous to that observed in the standard MD simulation with simulations on the order of picoseconds.

Physical Realization of a Supervised Learning System Built with Organic Memristive Synapses

NASA Astrophysics Data System (ADS)

Lin, Yu-Pu; Bennett, Christopher H.; Cabaret, Théo; Vodenicarevic, Damir; Chabi, Djaafar; Querlioz, Damien; Jousselme, Bruno; Derycke, Vincent; Klein, Jacques-Olivier

2016-09-01

Multiple modern applications of electronics call for inexpensive chips that can perform complex operations on natural data with limited energy. A vision for accomplishing this is implementing hardware neural networks, which fuse computation and memory, with low cost organic electronics. A challenge, however, is the implementation of synapses (analog memories) composed of such materials. In this work, we introduce robust, fastly programmable, nonvolatile organic memristive nanodevices based on electrografted redox complexes that implement synapses thanks to a wide range of accessible intermediate conductivity states. We demonstrate experimentally an elementary neural network, capable of learning functions, which combines four pairs of organic memristors as synapses and conventional electronics as neurons. Our architecture is highly resilient to issues caused by imperfect devices. It tolerates inter-device variability and an adaptable learning rule offers immunity against asymmetries in device switching. Highly compliant with conventional fabrication processes, the system can be extended to larger computing systems capable of complex cognitive tasks, as demonstrated in complementary simulations.

Optical design of cipher block chaining (CBC) encryption mode by using digital holography

NASA Astrophysics Data System (ADS)

Gil, Sang Keun; Jeon, Seok Hee; Jung, Jong Rae; Kim, Nam

2016-03-01

We propose an optical design of cipher block chaining (CBC) encryption by using digital holographic technique, which has higher security than the conventional electronic method because of the analog-type randomized cipher text with 2-D array. In this paper, an optical design of CBC encryption mode is implemented by 2-step quadrature phase-shifting digital holographic encryption technique using orthogonal polarization. A block of plain text is encrypted with the encryption key by applying 2-step phase-shifting digital holography, and it is changed into cipher text blocks which are digital holograms. These ciphered digital holograms with the encrypted information are Fourier transform holograms and are recorded on CCDs with 256 gray levels quantized intensities. The decryption is computed by these encrypted digital holograms of cipher texts, the same encryption key and the previous cipher text. Results of computer simulations are presented to verify that the proposed method shows the feasibility in the high secure CBC encryption system.

Minimized state complexity of quantum-encoded cryptic processes

NASA Astrophysics Data System (ADS)

Riechers, Paul M.; Mahoney, John R.; Aghamohammadi, Cina; Crutchfield, James P.

2016-05-01

The predictive information required for proper trajectory sampling of a stochastic process can be more efficiently transmitted via a quantum channel than a classical one. This recent discovery allows quantum information processing to drastically reduce the memory necessary to simulate complex classical stochastic processes. It also points to a new perspective on the intrinsic complexity that nature must employ in generating the processes we observe. The quantum advantage increases with codeword length: the length of process sequences used in constructing the quantum communication scheme. In analogy with the classical complexity measure, statistical complexity, we use this reduced communication cost as an entropic measure of state complexity in the quantum representation. Previously difficult to compute, the quantum advantage is expressed here in closed form using spectral decomposition. This allows for efficient numerical computation of the quantum-reduced state complexity at all encoding lengths, including infinite. Additionally, it makes clear how finite-codeword reduction in state complexity is controlled by the classical process's cryptic order, and it allows asymptotic analysis of infinite-cryptic-order processes.

Design, implementation and flight testing of PIF autopilots for general aviation aircraft

NASA Technical Reports Server (NTRS)

Broussard, J. R.

1983-01-01

The designs of Proportional-Integrated-Filter (PIF) auto-pilots for a General Aviation (NAVION) aircraft are presented. The PIF autopilot uses the sampled-data regulator and command generator tracking to determine roll select, pitch select, heading select, altitude select and localizer/glideslope capture and hold autopilot modes. The PIF control law uses typical General Aviation sensors for state feedback, command error integration for command tracking, digital complementary filtering and analog prefiltering for sensor noise suppression, a control filter for computation delay accommodation and the incremental form to eliminate trim values in implementation. Theoretical developments described in detail, were needed to combine the sampled-data regulator with command generator tracking for use as a digital flight control system. The digital PIF autopilots are evaluated using closed-loop eigenvalues and linear simulations. The implementation of the PIF autopilots in a digital flight computer using a high order language (FORTRAN) is briefly described. The successful flight test results for each PIF autopilot mode is presented.

Physical Realization of a Supervised Learning System Built with Organic Memristive Synapses.

PubMed

Lin, Yu-Pu; Bennett, Christopher H; Cabaret, Théo; Vodenicarevic, Damir; Chabi, Djaafar; Querlioz, Damien; Jousselme, Bruno; Derycke, Vincent; Klein, Jacques-Olivier

2016-09-07

Multiple modern applications of electronics call for inexpensive chips that can perform complex operations on natural data with limited energy. A vision for accomplishing this is implementing hardware neural networks, which fuse computation and memory, with low cost organic electronics. A challenge, however, is the implementation of synapses (analog memories) composed of such materials. In this work, we introduce robust, fastly programmable, nonvolatile organic memristive nanodevices based on electrografted redox complexes that implement synapses thanks to a wide range of accessible intermediate conductivity states. We demonstrate experimentally an elementary neural network, capable of learning functions, which combines four pairs of organic memristors as synapses and conventional electronics as neurons. Our architecture is highly resilient to issues caused by imperfect devices. It tolerates inter-device variability and an adaptable learning rule offers immunity against asymmetries in device switching. Highly compliant with conventional fabrication processes, the system can be extended to larger computing systems capable of complex cognitive tasks, as demonstrated in complementary simulations.

Measurement of temperature and pressure on the surface of a blunt cone using FBG sensor in hypersonic wind tunnel

NASA Astrophysics Data System (ADS)

Prasad, A. S. Guru; Sharath, U.; Nagarjun, V.; Hegde, G. M.; Asokan, S.

2013-09-01

Measurement of temperature and pressure exerted on the leeward surface of a blunt cone specimen has been demonstrated in the present work in a hypersonic wind tunnel using fiber Bragg grating (FBG) sensors. The experiments were conducted on a 30° apex-angle blunt cone with 51 mm base diameter at wind flow speeds of Mach 6.5 and 8.35 in a 300 mm hypersonic wind tunnel of Indian Institute of Science, Bangalore. A special pressure insensitive temperature sensor probe along with the conventional bare FBG sensors was used for explicit temperature and aerodynamic pressure measurement respectively on the leeward surface of the specimen. computational fluid dynamics (CFD) simulation of the flow field around the blunt cone specimen has also been carried out to obtain the temperature and pressure at conditions analogous to experiments. The results obtained from FBG sensors and the CFD simulations are found to be in good agreement with each other.

Modeling and control design of a wind tunnel model support

NASA Technical Reports Server (NTRS)

Howe, David A.

1990-01-01

The 12-Foot Pressure Wind Tunnel at Ames Research Center is being restored. A major part of the restoration is the complete redesign of the aircraft model supports and their associated control systems. An accurate trajectory control servo system capable of positioning a model (with no measurable overshoot) is needed. Extremely small errors in scaled-model pitch angle can increase airline fuel costs for the final aircraft configuration by millions of dollars. In order to make a mechanism sufficiently accurate in pitch, a detailed structural and control-system model must be created and then simulated on a digital computer. The model must contain linear representations of the mechanical system, including masses, springs, and damping in order to determine system modes. Electrical components, both analog and digital, linear and nonlinear must also be simulated. The model of the entire closed-loop system must then be tuned to control the modes of the flexible model-support structure. The development of a system model, the control modal analysis, and the control-system design are discussed.

First-Order SPICE Modeling of Extreme-Temperature 4H-SiC JFET Integrated Circuits

NASA Technical Reports Server (NTRS)

Neudeck, Philip G.; Spry, David J.; Chen, Liang-Yu

2016-01-01

A separate submission to this conference reports that 4H-SiC Junction Field Effect Transistor (JFET) digital and analog Integrated Circuits (ICs) with two levels of metal interconnect have reproducibly demonstrated electrical operation at 500 C in excess of 1000 hours. While this progress expands the complexity and durability envelope of high temperature ICs, one important area for further technology maturation is the development of reasonably accurate and accessible computer-aided modeling and simulation tools for circuit design of these ICs. Towards this end, we report on development and verification of 25 C to 500 C SPICE simulation models of first order accuracy for this extreme-temperature durable 4H-SiC JFET IC technology. For maximum availability, the JFET IC modeling is implemented using the baseline-version SPICE NMOS LEVEL 1 model that is common to other variations of SPICE software and importantly includes the body-bias effect. The first-order accuracy of these device models is verified by direct comparison with measured experimental device characteristics.

Peptides at Membrane Surfaces and their Role in the Origin of Life

NASA Technical Reports Server (NTRS)

Pohorille, Andrew; Wilson, Michael A.; DeVincenzi, D. (Technical Monitor)

2002-01-01

All ancestors of contemporary cells (protocells) had to transport ions and organic matter across membranous walls, capture and utilize energy and transduce environmental signals. In modern organisms, all these functions are preformed by membrane proteins. We make the parsimonious assumption that in the protobiological milieu the same functions were carried out by their simple analogs - peptides. This, however, required that simple peptides could self-organize into ordered, functional structures. In a series of detailed, molecular-level computer simulations we demonstrated how this is possible. One example is the peptide (LSLLLSL)3 which forms a trameric bundle capable of transporting protons across membranes. Another example is the transmembrane pore of the influenza M2 protein. This aggregate of four identical alpha-helices, each built of 25 amino acids, forms an efficient and selective voltage-gated proton channel. Our simulations explain the gating mechanism in this channel. The channel can be re-engineered into a simple proton pump.

Fundamental frequencies and resonances from eccentric and precessing binary black hole inspirals

NASA Astrophysics Data System (ADS)

Lewis, Adam G. M.; Zimmerman, Aaron; Pfeiffer, Harald P.

2017-06-01

Binary black holes which are both eccentric and undergo precession remain unexplored in numerical simulations. We present simulations of such systems which cover about 50 orbits at comparatively high mass ratios 5 and 7. The configurations correspond to the generic motion of a nonspinning body in a Kerr spacetime, and are chosen to study the transition from finite mass-ratio inspirals to point particle motion in Kerr. We develop techniques to extract analogs of the three fundamental frequencies of Kerr geodesics, compare our frequencies to those of Kerr, and show that the differences are consistent with self-force corrections entering at first order in mass ratio. This analysis also locates orbital resonances where the ratios of our frequencies take rational values. At the considered mass ratios, the binaries pass through resonances in one to two resonant cycles, and we find no discernible effects on the orbital evolution. We also compute the decay of eccentricity during the inspiral and find good agreement with the leading order post-Newtonian prediction.

ADVANTG An Automated Variance Reduction Parameter Generator, Rev. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mosher, Scott W.; Johnson, Seth R.; Bevill, Aaron M.

2015-08-01

The primary objective of ADVANTG is to reduce both the user effort and the computational time required to obtain accurate and precise tally estimates across a broad range of challenging transport applications. ADVANTG has been applied to simulations of real-world radiation shielding, detection, and neutron activation problems. Examples of shielding applications include material damage and dose rate analyses of the Oak Ridge National Laboratory (ORNL) Spallation Neutron Source and High Flux Isotope Reactor (Risner and Blakeman 2013) and the ITER Tokamak (Ibrahim et al. 2011). ADVANTG has been applied to a suite of radiation detection, safeguards, and special nuclear materialmore » movement detection test problems (Shaver et al. 2011). ADVANTG has also been used in the prediction of activation rates within light water reactor facilities (Pantelias and Mosher 2013). In these projects, ADVANTG was demonstrated to significantly increase the tally figure of merit (FOM) relative to an analog MCNP simulation. The ADVANTG-generated parameters were also shown to be more effective than manually generated geometry splitting parameters.« less

The activation of phosphoramide mustard anticancer drugs from ab initio simulations.

NASA Astrophysics Data System (ADS)

Allesch, Markus; Schwegler, Eric; Colvin, Mike; Gygi, Francois; Galli, Giulia

2007-03-01

The nitrogen mustard based DNA alkylating agents were the first nonhormonal drugs to be used effectively in the treatment of cancer and remain one of the most important drugs for the chemotherapeutic management of many common malignancies today. An understanding of the activation of these compounds is, in itself, of scientific interest, but also critical in designing improved analogs of greater selectivity and efficacy. We have investigated the activation pathways of one of the most active metabolites, phosphoramide mustard (PM), and its methylated ester (PMME). In particular, we have examined the activation barrier and reaction free energy for the intramolecular cyclization reaction using first principles molecular dynamics simulations with explicit and continuum solvation models. Structural, dynamical and electronic properties along the reaction path have been computed mainly to address the question why de-esterification is required to activate these drugs. This work was performed under the auspices of the U.S. Dept. of Energy at the University of California/Lawrence Livermore National Laboratory under contract no. W-7405-Eng-48.

On the Computation of Sound by Large-Eddy Simulations

NASA Technical Reports Server (NTRS)

Piomelli, Ugo; Streett, Craig L.; Sarkar, Sutanu

1997-01-01

The effect of the small scales on the source term in Lighthill's acoustic analogy is investigated, with the objective of determining the accuracy of large-eddy simulations when applied to studies of flow-generated sound. The distribution of the turbulent quadrupole is predicted accurately, if models that take into account the trace of the SGS stresses are used. Its spatial distribution is also correct, indicating that the low-wave-number (or frequency) part of the sound spectrum can be predicted well by LES. Filtering, however, removes the small-scale fluctuations that contribute significantly to the higher derivatives in space and time of Lighthill's stress tensor T(sub ij). The rms fluctuations of the filtered derivatives are substantially lower than those of the unfiltered quantities. The small scales, however, are not strongly correlated, and are not expected to contribute significantly to the far-field sound; separate modeling of the subgrid-scale density fluctuations might, however, be required in some configurations.