Error and Symmetry Analysis of Misner's Algorithm for Spherical Harmonic Decomposition on a Cubic Grid

NASA Technical Reports Server (NTRS)

Fiske, David R.

2004-01-01

In an earlier paper, Misner (2004, Class. Quant. Grav., 21, S243) presented a novel algorithm for computing the spherical harmonic components of data represented on a cubic grid. I extend Misner s original analysis by making detailed error estimates of the numerical errors accrued by the algorithm, by using symmetry arguments to suggest a more efficient implementation scheme, and by explaining how the algorithm can be applied efficiently on data with explicit reflection symmetries.

Typing single polymorphic nucleotides in mitochondrial DNA as a way to access Middle Pleistocene DNA

PubMed Central

Valdiosera, Cristina; García, Nuria; Dalén, Love; Smith, Colin; Kahlke, Ralf-Dietrich; Lidén, Kerstin; Angerbjörn, Anders; Arsuaga, Juan Luis; Götherström, Anders

2006-01-01

In this study, we have used a technique designed to target short fragments containing informative mitochondrial substitutions to extend the temporal limits of DNA recovery and study the molecular phylogeny of Ursus deningeri. We present a cladistic analysis using DNA recovered from 400 kyr old U. deningeri remains, which demonstrates U. deningeri's relation to Ursus spelaeus. This study extends the limits of recovery from skeletal remains by almost 300 kyr. Plant material from permafrost environments has yielded DNA of this age in earlier studies, and our data suggest that DNA in teeth from cave environments may be equally well preserved. PMID:17148299

Late Permian marine ecosystem collapse began in deeper waters: evidence from brachiopod diversity and body size changes.

PubMed

He, W-H; Shi, G R; Twitchett, R J; Zhang, Y; Zhang, K-X; Song, H-J; Yue, M-L; Wu, S-B; Wu, H-T; Yang, T-L; Xiao, Y-F

2015-03-01

Analysis of Permian-Triassic brachiopod diversity and body size changes from different water depths spanning the continental shelf to basinal facies in South China provides insights into the process of environmental deterioration. Comparison of the temporal changes of brachiopod diversity between deepwater and shallow-water facies demonstrates that deepwater brachiopods disappeared earlier than shallow-water brachiopods. This indicates that high environmental stress commenced first in deepwater settings and later extended to shallow waters. This environmental stress is attributed to major volcanic eruptions, which first led to formation of a stratified ocean and a chemocline in the outer shelf and deeper water environments, causing the disappearance of deep marine benthos including brachiopods. The chemocline then rapidly migrated upward and extended to shallow waters, causing widespread mass extinction of shallow marine benthos. We predict that the spatial and temporal patterns of earlier onset of disappearance/extinction and ecological crisis in deeper water ecosystems will be recorded during other episodes of rapid global warming. © 2014 John Wiley & Sons Ltd.

A supplemental catalog of atmospheric densities from satellite-drag analysis

NASA Technical Reports Server (NTRS)

Jacchia, L. G.; Slowey, J. W.

1972-01-01

The catalog of densities derived from satellite-drag analysis extends and supplements similar earlier publications. The densities were computed from nine artificial satellites for effective heights ranging from 300 to 1130 km, and are presented together with pertinent data that permit the location in time and space of the point to which they refer. The intervals covered vary between 1 and 6 years for the different satellites and average about 3.5 years for the nine satellites. The cutoff date for the data included is, in most cases, January 14, 1970.

A Parallel Independent Component Analysis Approach to Investigate Genomic Influence on Brain Function

PubMed Central

Liu, Jingyu; Demirci, Oguz; Calhoun, Vince D.

2009-01-01

Relationships between genomic data and functional brain images are of great interest but require new analysis approaches to integrate the high-dimensional data types. This letter presents an extension of a technique called parallel independent component analysis (paraICA), which enables the joint analysis of multiple modalities including interconnections between them. We extend our earlier work by allowing for multiple interconnections and by providing important overfitting controls. Performance was assessed by simulations under different conditions, and indicated reliable results can be extracted by properly balancing overfitting and underfitting. An application to functional magnetic resonance images and single nucleotide polymorphism array produced interesting findings. PMID:19834575

A Parallel Independent Component Analysis Approach to Investigate Genomic Influence on Brain Function.

PubMed

Liu, Jingyu; Demirci, Oguz; Calhoun, Vince D

2008-01-01

Relationships between genomic data and functional brain images are of great interest but require new analysis approaches to integrate the high-dimensional data types. This letter presents an extension of a technique called parallel independent component analysis (paraICA), which enables the joint analysis of multiple modalities including interconnections between them. We extend our earlier work by allowing for multiple interconnections and by providing important overfitting controls. Performance was assessed by simulations under different conditions, and indicated reliable results can be extracted by properly balancing overfitting and underfitting. An application to functional magnetic resonance images and single nucleotide polymorphism array produced interesting findings.

Photoabsorption and photodissociation studies of dimethyl sulphoxide (DMSO) in the 35,000-80,000 cm-1 region using synchrotron radiation

NASA Astrophysics Data System (ADS)

Mandal, Anuvab; Singh, Param Jeet; Shastri, Aparna; Sunanda, K.; Jagatap, B. N.

2015-05-01

Photoabsorption and photodissociation studies of dimethyl sulphoxide and its deuterated isotopologue (DMSO-h6 and DMSO-d6) are performed using synchrotron radiation in the 35,000-80,000 cm-1 region. In the photoabsorption spectrum, Rydberg series converging to the first three ionization potentials of DMSO at 9.1, 10.1 and 12.3 eV corresponding to removal of an electron from the highest three occupied molecular orbitals (14a‧, 7a″ and 13a‧) are observed. Based on a quantum defect analysis, Rydberg series assignments are extended to higher members as compared to earlier works and a few ambiguities in earlier assignments are clarified. Analysis is aided by quantum chemical calculations using the DFT and TDDFT methodologies. Vibronic structures observed in the spectrum of DMSO-h6 in the regions 7.7-8.1 eV and 8.1-8.8 eV are attributed to the transitions 7a″→4p at 7.862 eV and 14a‧→6s/4d at 8.182 eV, respectively. Photoabsorption spectra of DMSO-h6 and -d6 recorded using a broad band incident radiation show prominent peaks, which are identified and assigned to electronic and vibronic transitions of the SO radical. This provides a direct confirmation of the fact that DMSO preferentially dissociates into CH3 and SO upon UV-VUV excitation, as proposed in earlier photodissociation studies. An extended vibronic band system associated with the e1Π-X3Σ- transition of the SO radical is identified and assigned. The complete VUV photoabsorption spectrum of DMSO-d6 is also reported here for the first time.

Generalist Genes and Learning Disabilities: A Multivariate Genetic Analysis of Low Performance in Reading, Mathematics, Language and General Cognitive Ability in a Sample of 8000 12-Year-Old Twins

ERIC Educational Resources Information Center

Haworth, Claire M. A.; Kovas, Yulia; Harlaar, Nicole; Hayiou-Thomas, Marianna E.; Petrill, Stephen A.; Dale, Philip S.; Plomin, Robert

2009-01-01

Background: Our previous investigation found that the same genes influence poor reading and mathematics performance in 10-year-olds. Here we assess whether this finding extends to language and general cognitive disabilities, as well as replicating the earlier finding for reading and mathematics in an older and larger sample. Methods: Using a…

Outer satellite atmospheres: Their extended nature and planetary interactions. [sodium cloud of Io, hydrogen torus of Titan, and comet atmospheres

NASA Technical Reports Server (NTRS)

Smyth, W. H.

1980-01-01

Highly developed numerical models are applied to interpret extended-atmosphere data for the sodium cloud of Io and the hydrogen torus of Titan. Solar radiation pressure was identified and verified by model calculations as the mechanism to explain two different east-west asymmetries observed in the sodium cloud. Analysis of sodium line profile data, suggesting that a Jupiter magnetospheric wind may be responsible for high speed sodium atoms emitted from Io, and preliminary modeling of the interaction of the Io plasma torus and Io's sodium cloud are also reported. Models presented for Titan's hydrogen torus are consistent both with the recent Pioneer 11 measurements and earlier Earth-orbiting observations by the Copernicus satellite. Progress is reported on developing models for extended gas and dust atmospheres of comets.

COMET-AR User's Manual: COmputational MEchanics Testbed with Adaptive Refinement

NASA Technical Reports Server (NTRS)

Moas, E. (Editor)

1997-01-01

The COMET-AR User's Manual provides a reference manual for the Computational Structural Mechanics Testbed with Adaptive Refinement (COMET-AR), a software system developed jointly by Lockheed Palo Alto Research Laboratory and NASA Langley Research Center under contract NAS1-18444. The COMET-AR system is an extended version of an earlier finite element based structural analysis system called COMET, also developed by Lockheed and NASA. The primary extensions are the adaptive mesh refinement capabilities and a new "object-like" database interface that makes COMET-AR easier to extend further. This User's Manual provides a detailed description of the user interface to COMET-AR from the viewpoint of a structural analyst.

Extended roles for allied health professionals: an updated systematic review of the evidence

PubMed Central

Saxon, Robyn L; Gray, Marion A; Oprescu, Florin I

2014-01-01

Background Internationally, health care services are under increasing pressure to provide high quality, accessible, timely interventions to an ever increasing aging population, with finite resources. Extended scope roles for allied health professionals is one strategy that could be undertaken by health care services to meet this demand. This review builds upon an earlier paper published in 2006 on the evidence relating to the impact extended scope roles have on health care services. Methods A systematic review of the literature focused on extended scope roles in three allied health professional groups, ie, physiotherapy, occupational therapy, and speech pathology, was conducted. The search strategy mirrored an earlier systematic review methodology and was designed to include articles from 2005 onwards. All peer-reviewed published papers with evidence relating to effects on patients, other professionals, or the health service were included. All papers were critically appraised prior to data extraction. Results A total of 1,000 articles were identified by the search strategy; 254 articles were screened for relevance and 21 progressed to data extraction for inclusion in the systematic review. Conclusion Literature supporting extended scope roles exists; however, despite the earlier review calling for more robust evaluations regarding the impact on patient outcomes, cost-effectiveness, training requirements, niche identification, or sustainability, there appears to be limited research reported on the topic in the last 7 years. The evidence available suggests that extended scope practice allied health practitioners could be a cost-effective and consumer-accepted investment that health services can make to improve patient outcomes. PMID:25342909

Trends in surface ozone over Europe, 1978-1990

NASA Technical Reports Server (NTRS)

Low, Pak Sum; Kelly, P. Michael; Davies, Trevor D.

1994-01-01

It has been suggested that surface ozone concentrations in rural areas of Europe have been increasing at a rate of 1 to 3 percent per year over the past two to three decades, presumably due to human influences (Feister and Warmbt, 1987; Bojkov, 1988; Penkett, 1989). Recently, we have analyzed surface ozone data from 20 European stations of differing character (remote, rural, suburban and urban) for a common period of 1978-1988 (Low et al., 1992). It was found that there were pronounced annual and seasonal variations in the linear trends in different areas, and there was no dominant region-wide trend. In spring and, most notably, summer, stations on the maritime fringe of the network generally exhibited negative trends whilst those located further into the continental interior exhibited positive trends. In winter, most of the stations in the network exhibited positive trends. Relatively few of these trends were statistically significant. This paper updates our earlier analysis by extending the data sets of the network up to the year 1990. The spatial variations in surface ozone trends over the extended period 1978-1990 are examined and discussed in comparison to the 1978-1988 patterns. The update confirms the overall conclusions of the earlier analysis, specifically that caution should be exercised in interpreting the results of trend analyses based on station data representative of a limited period of time and/or geographical area.

Career Decision Status as a Predictor of Resignation Behavior Five Years Later

ERIC Educational Resources Information Center

Earl, Joanne K.; Minbashian, Amirali; Sukijjakhamin, Aun; Bright, Jim E. H.

2011-01-01

This paper extends earlier research exploring the relationship between career decision status and work outcomes by examining resignation behavior in a group of new graduates five years after initial appointment. On appointment various measures were collected including career decision status variables. Earlier research identified a significant…

Extended investigation of the twelve-flavor β-function

NASA Astrophysics Data System (ADS)

Fodor, Zoltán; Holland, Kieran; Kuti, Julius; Nógrádi, Dániel; Wong, Chik Him

2018-04-01

We report new results from high precision analysis of an important BSM gauge theory with twelve massless fermion flavors in the fundamental representation of the SU(3) color gauge group. The range of the renormalized gauge coupling is extended from our earlier work [1] to probe the existence of an infrared fixed point (IRFP) in the β-function reported at two different locations, originally in [2] and at a new location in [3]. We find no evidence for the IRFP of the β-function in the extended range of the renormalized gauge coupling, in disagreement with [2,3]. New arguments to guard the existence of the IRFP remain unconvincing [4], including recent claims of an IRFP with ten massless fermion flavors [5,6] which we also rule out. Predictions of the recently completed 5-loop QCD β-function for general flavor number are discussed in this context.

Ergodic theory and visualization. II. Fourier mesochronic plots visualize (quasi)periodic sets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levnajić, Zoran; Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, California 93106; Mezić, Igor

We present an application and analysis of a visualization method for measure-preserving dynamical systems introduced by I. Mezić and A. Banaszuk [Physica D 197, 101 (2004)], based on frequency analysis and Koopman operator theory. This extends our earlier work on visualization of ergodic partition [Z. Levnajić and I. Mezić, Chaos 20, 033114 (2010)]. Our method employs the concept of Fourier time average [I. Mezić and A. Banaszuk, Physica D 197, 101 (2004)], and is realized as a computational algorithms for visualization of periodic and quasi-periodic sets in the phase space. The complement of periodic phase space partition contains chaotic zone,more » and we show how to identify it. The range of method's applicability is illustrated using well-known Chirikov standard map, while its potential in illuminating higher-dimensional dynamics is presented by studying the Froeschlé map and the Extended Standard Map.« less

Ergodic theory and visualization. II. Fourier mesochronic plots visualize (quasi)periodic sets.

PubMed

Levnajić, Zoran; Mezić, Igor

2015-05-01

We present an application and analysis of a visualization method for measure-preserving dynamical systems introduced by I. Mezić and A. Banaszuk [Physica D 197, 101 (2004)], based on frequency analysis and Koopman operator theory. This extends our earlier work on visualization of ergodic partition [Z. Levnajić and I. Mezić, Chaos 20, 033114 (2010)]. Our method employs the concept of Fourier time average [I. Mezić and A. Banaszuk, Physica D 197, 101 (2004)], and is realized as a computational algorithms for visualization of periodic and quasi-periodic sets in the phase space. The complement of periodic phase space partition contains chaotic zone, and we show how to identify it. The range of method's applicability is illustrated using well-known Chirikov standard map, while its potential in illuminating higher-dimensional dynamics is presented by studying the Froeschlé map and the Extended Standard Map.

FUB at TREC 2008 Relevance Feedback Track: Extending Rocchio with Distributional Term Analysis

DTIC Science & Technology

2008-11-01

starting point is the improved version [ Salton and Buckley 1990] of the original Rocchio’s formula [Rocchio 1971]: newQ = α ⋅ origQ + β R r r∈R ∑ − γR...earlier studies about the low effect of the main relevance feedback parameters on retrieval performance (e.g., Salton and Buckley 1990), while they seem...Relevance feedback in information retrieval. In The SMART retrieval system - experiments in automatic document processing, Salton , G., Ed., Prentice Hall

Free and Compulsory School Age Requirements. ECS 50-State Reviews

ERIC Educational Resources Information Center

Aragon, Stephanie

2015-01-01

Policymakers across the nation continue to push for expanded free and compulsory school age requirements. More states are considering granting students earlier access to a free education so that they can begin their academic pursuits earlier in life. Similarly, every year a number of states consider extending the upper limit for compulsory school…

The Psychological Effects of Unemployment and Unsatisfactory Employment on Young Adults: Findings from a 10-Year Longitudinal Study.

PubMed

Winefield, Anthony H; Delfabbro, Paul H; Winefield, Helen R; Duong, David; Malvaso, Catia

2017-01-01

The purpose of the present study was to extend the external validity of an earlier longitudinal study of school leavers by including participants from a representative sample of secondary schools. Questionnaires were administered annually to a sample of South Australian school leavers over a 10-year period. At Time 1 participants were in the last compulsory year of high school aged around 15 years and at Time 10 they were aged around 25 years. Results confirmed those from an earlier longitudinal study showing that the transition from school to satisfactory employment was associated with significant improvements in psychological well-being, whereas transition from school to unemployment or unsatisfactory employment showed no change in psychological well-being. The current findings extended the external validity of the earlier study because whereas participants in the earlier study were sampled from co-educational metropolitan public high schools, the current study included participants from every kind of high school: single sex as well as co-educational, rural as well as metropolitan, and private as well as public.

Software Requirements Analysis as Fault Predictor

NASA Technical Reports Server (NTRS)

Wallace, Dolores

2003-01-01

Waiting until the integration and system test phase to discover errors leads to more costly rework than resolving those same errors earlier in the lifecycle. Costs increase even more significantly once a software system has become operational. WE can assess the quality of system requirements, but do little to correlate this information either to system assurance activities or long-term reliability projections - both of which remain unclear and anecdotal. Extending earlier work on requirements accomplished by the ARM tool, measuring requirements quality information against code complexity and test data for the same system may be used to predict specific software modules containing high impact or deeply embedded faults now escaping in operational systems. Such knowledge would lead to more effective and efficient test programs. It may enable insight into whether a program should be maintained or started over.

Integrated cosmological probes: Extended analysis

NASA Astrophysics Data System (ADS)

Nicola, Andrina; Refregier, Alexandre; Amara, Adam

2017-04-01

Recent progress in cosmology has relied on combining different cosmological probes. In an earlier work, we implemented an integrated approach to cosmology where the probes are combined into a common framework at the map level. This has the advantage of taking full account of the correlations between the different probes, to provide a stringent test of systematics and of the validity of the cosmological model. We extend this analysis to include not only cosmic microwave background (CMB) temperature, galaxy clustering, and weak lensing from the Sloan Digital Sky Survey (SDSS) but also CMB lensing, weak lensing from Dark Energy Survey Science Verification (DES SV) data, type Ia supernova, and H0 measurements. This yields 12 auto- and cross-power spectra which include the CMB temperature power spectrum, cosmic shear, galaxy clustering, galaxy-galaxy lensing, CMB lensing cross-correlation along with other cross-correlations, as well as background probes. Furthermore, we extend the treatment of systematic uncertainties by studying the impact of intrinsic alignments, baryonic corrections, residual foregrounds in the CMB temperature, and calibration factors for the different power spectra. For Λ CDM , we find results that are consistent with our earlier work. Given our enlarged data set and systematics treatment, this confirms the robustness of our analysis and results. Furthermore, we find that our best-fit cosmological model gives a good fit to all the data we consider with no signs of tensions within our analysis. We also find our constraints to be consistent with those found by the joint analysis of the WMAP9, SPT, and ACT CMB experiments and the KiDS weak lensing survey. Comparing with the Planck Collaboration results, we see a broad agreement, but there are indications of a tension from the marginalized constraints in most pairs of cosmological parameters. Since our analysis includes CMB temperature Planck data at 10 <ℓ<610 , the tension appears to arise between the Planck high-ℓ modes and the other measurements. Furthermore, we find the constraints on the probe calibration parameters to be in agreement with expectations, showing that the data sets are mutually consistent. In particular, this yields a confirmation of the amplitude calibration of the weak lensing measurements from the SDSS, DES SV, and Planck CMB lensing from our integrated analysis.

Flowering and seed dispersal of dwarfmistletoe (Arceuthobium campylopodum in California

Treesearch

Robert F. Scharpf

1965-01-01

Under the short growing season of the Sierra Nevada, both flowering and seed dispersal of Arceuthobium campylopodum occurred earlier in the fall and dispersal extended for a shorter duration than at lower elevations and along the coast of California. Also in years of above normal surrmer temperatures, flowering and seed dispersal occurred earlier in...

Postpartum Maternal Moods and Infant Size Predict Performance on a National High School Entrance Examination

ERIC Educational Resources Information Center

Galler, Janina R.; Ramsey, Frank C.; Harrison, Robert H.; Taylor, John; Cumberbatch, Glenroy; Forde, Victor

2004-01-01

Background: In an earlier series of studies, we documented the effects of feeding practices and postnatal maternal mood on the growth and development of 226 Barbadian children during the first few months of life. In this report, we extend our earlier studies by examining predictive relationships between infant size, feeding practices and…

Another Look at the Relative Impact of Workplace Design on Training Transfer for Supervisory Communication Skills

ERIC Educational Resources Information Center

Hillsman, Terron L.; Kupritz, Virginia W.

2010-01-01

This ethnographic study extends the findings of earlier research that authenticated the impact of workplace design features on newly acquired communication skills back on the job. The qualitative nature of the earlier study, however, limited quantitative measurement of workplace design features that may have an impact on learned skills. This study…

Narrative Skill in Children with Early Unilateral Brain Injury: A Possible Limit to Functional Plasticity

ERIC Educational Resources Information Center

Demir, Ozlem Ece; Levine, Susan C.; Goldin-Meadow, Susan

2010-01-01

Children with pre- or perinatal brain injury (PL) exhibit marked plasticity for language learning. Previous work has focused mostly on the emergence of earlier-developing skills, such as vocabulary and syntax. Here we ask whether this plasticity for earlier-developing aspects of language extends to more complex, later-developing language functions…

A better outlook for schizophrenics living in extended families.

PubMed

El-Islam, E F

1979-10-01

Cases of schizophrenia and schizophreniform attacks living in extended families have been compared to cases with similar diagnoses in nuclear families. Both diagnostic groups living in extended families presented earlier: they had lower rates of withdrawal symptoms and higher rates of behavioural disturbances and subjective suffering. Inter-generational conflict was a significantly more common precipitating factor in patients living in extended families; this was therapeutically utilized to induce family support. Patients from extended families had a lower tendency to deteriorate into with drawn, affectively blunted residual states.

Long dance of the bashful ballerina

NASA Astrophysics Data System (ADS)

Hiltula, T.; Mursula, K.

2006-02-01

In this letter we extend our earlier analysis of the north-south asymmetry of the heliospheric current sheet (HCS) using a recent data set of heliospheric magnetic field (HMF) sector polarities extracted from ground-based magnetic observations. We find that the heliospheric current sheet is similarly southward coned or shifted during the late declining to minimum phase of the solar cycle in the early part of the studied data interval (1926-1955), as earlier found for the more recent solar cycles. Accordingly, the HCS has been southward shifted; that is, the solar ballerina has been bashful at least during the last 80 years. We also discuss solar cycle 19 which presents a period of a very curious behaviour for the HCS with an exceptionally large HMF toward sector dominance in 1957, the year of cycle 19 maximum, and an equally strong HMF away sector dominance in 1960, the time of final solar polarity reversal.

The thickness of the shower disc as observed in showers produced by primaries above 10 (19)eV

NASA Technical Reports Server (NTRS)

Lawrence, M. A.; Watson, A. A.; West, A. A.

1985-01-01

The thickness of the shower disk has been measured in showers initiated by primaries of energy to 10 the 19th power eV using the large area water Cerenkov detectors of the Haverah Park array. Results are presented which (1) provide supporting evidence for the accuracy of analysis procedures in giant showers, (2) offer an evaluation of the mini-array technique for the detection of giant showers and (3) extend earlier work on developmental fluctuations above 10 to the 19th power eV.

Entrainment-Zone Restratification and Flow Structures in Stratified Shear Turbulence

NASA Technical Reports Server (NTRS)

Reif, B. Anders Pettersson; Werne, Joseph; Andreassen, Oyvind; Meyer, Christian; Davis-Mansour, Melissa

2002-01-01

Late-time dynamics and morphology of a stratified turbulent shear layer are examined using 1) Reynolds-stress and heat-flux budgets, 2) the single-point structure tensors introduced by Kassinos et al. (2001), and 3) flow visualization via 3D volume rendering. Flux reversal is observed during restratification in the edges of the turbulent layer. We present a first attempt to quantify the turbulence-mean-flow interaction and to characterize the predominant flow structures. Future work will extend this analysis to earlier times and different values of the Reynolds and Richardson numbers.

Study on structural recovery of graphite irradiated with swift heavy ions at high temperature

NASA Astrophysics Data System (ADS)

Pellemoine, F.; Avilov, M.; Bender, M.; Ewing, R. C.; Fernandes, S.; Lang, M.; Li, W. X.; Mittig, W.; Schein, M.; Severin, D.; Tomut, M.; Trautmann, C.; Zhang, F. X.

2015-12-01

Thin graphite foils bombarded with an intense high-energy (8.6 MeV/u) gold beam reaching fluences up to 1 × 1015 ions/cm2 lead to swelling and electrical resistivity changes. As shown earlier, these effects are diminished with increasing irradiation temperature. The work reported here extends the investigation of beam induced changes of these samples by structural analysis using synchrotron X-ray diffraction and transmission electron microscope. A nearly complete recovery from swelling at irradiation temperatures above about 1500 °C is identified.

76 FR 18383 - Extension of Sunset Date for Attorney Advisor Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-04

... rule. SUMMARY: We are extending for 2 years our rule authorizing attorney advisors to conduct certain prehearing procedures and to issue fully favorable decisions. The current rule will expire on August 10, 2011... would end on August 10, 2009, unless we decided either to terminate the rule earlier or to extend it...

Fermi detection of delayed GeV emission from the short gamma-ray burst 081024B

DOE PAGES

Abdo, A. A.

2010-03-03

Here, we report on the detailed analysis of the high-energy extended emission from the short gamma-ray burst (GRB) 081024B detected by the Fermi Gamma-ray Space Telescope. Historically, this represents the first clear detection of temporal extended emission from a short GRB. Furthermore, the light curve observed by the Fermi Gamma-ray Burst Monitor lasts approximately 0.8 s whereas the emission in the Fermi Large Area Telescope lasts for about 3 s. Evidence of longer lasting high-energy emission associated with long bursts has been already reported by previous experiments. These observations, together with the earlier reported study of the bright short GRBmore » 090510, indicate similarities in the high-energy emission of short and long GRBs and open the path to new interpretations.« less

75 FR 1107 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

... Proposed Rule Change Amending NYSE Rule 123C(8)(a)(1) To Extend Operation of the Extreme Order Imbalances... suspend certain rule requirements at the close when extreme order imbalances may cause significant... Imbalances Pilot'' or ``Pilot'').\\3\\ Through this filing, NYSE proposes to extend the Pilot until the earlier...

Analysis and design of optical systems by use of sensitivity analysis of skew ray tracing

NASA Astrophysics Data System (ADS)

Lin, Psang Dain; Lu, Chia-Hung

2004-02-01

Optical systems are conventionally evaluated by ray-tracing techniques that extract performance quantities such as aberration and spot size. Current optical analysis software does not provide satisfactory analytical evaluation functions for the sensitivity of an optical system. Furthermore, when functions oscillate strongly, the results are of low accuracy. Thus this work extends our earlier research on an advanced treatment of reflected or refracted rays, referred to as sensitivity analysis, in which differential changes of reflected or refracted rays are expressed in terms of differential changes of incident rays. The proposed sensitivity analysis methodology for skew ray tracing of reflected or refracted rays that cross spherical or flat boundaries is demonstrated and validated by the application of a cat's eye retroreflector to the design and by the image orientation of a system with noncoplanar optical axes. The proposed sensitivity analysis is projected as the nucleus of other geometrical optical computations.

Analysis and Design of Optical Systems by Use of Sensitivity Analysis of Skew Ray Tracing

NASA Astrophysics Data System (ADS)

Dain Lin, Psang; Lu, Chia-Hung

2004-02-01

Optical systems are conventionally evaluated by ray-tracing techniques that extract performance quantities such as aberration and spot size. Current optical analysis software does not provide satisfactory analytical evaluation functions for the sensitivity of an optical system. Furthermore, when functions oscillate strongly, the results are of low accuracy. Thus this work extends our earlier research on an advanced treatment of reflected or refracted rays, referred to as sensitivity analysis, in which differential changes of reflected or refracted rays are expressed in terms of differential changes of incident rays. The proposed sensitivity analysis methodology for skew ray tracing of reflected or refracted rays that cross spherical or flat boundaries is demonstrated and validated by the application of a cat ?s eye retroreflector to the design and by the image orientation of a system with noncoplanar optical axes. The proposed sensitivity analysis is projected as the nucleus of other geometrical optical computations.

Effects of extended photoperiod on sandhill crane reproduction

USGS Publications Warehouse

Gee, G.F.; Pendleton, G.W.; Wood, Don A.

1992-01-01

Photoperiod studies were conducted with greater sandhill cranes (Grus canadensis tabida) from 1969 to 1972 and from 1982 to 1987 at the Patuxent Wildlife Research Center, Maryland. When housed indoors and exposed to long photoperiods, males produced semen during winter. When exposed to artificially extended photoperiods during spring in outdoor pens, females apparently laid earlier in the year and laid more eggs than they would have without the added light. Cranes did not exhibit any signs of photorefractory response to extended photoperiods.

Limited Range Sesame EOS for Ta

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greeff, Carl William; Crockett, Scott; Rudin, Sven Peter

2017-03-30

A new Sesame EOS table for Ta has been released for testing. It is a limited range table covering T ≤ 26, 000 K and ρ ≤ 37.53 g/cc. The EOS is based on earlier analysis using DFT phonon calculations to infer the cold pressure from the Hugoniot. The cold curve has been extended into compression using new DFT calculations. The present EOS covers expansion into the gas phase. It is a multi-phase EOS with distinct liquid and solid phases. A cold shear modulus table (431) is included. This is based on an analytic interpolation of DFT calculations.

Resistive wall wakefields of short bunches at cryogenic temperatures

DOE PAGES

Stupakov, G.; Bane, K. L. F.; Emma, P.; ...

2015-03-19

In this study, we present calculations of the longitudinal wakefields at cryogenic temperatures for extremely short bunches, characteristic for modern x-ray free electron lasers. The calculations are based on the equations for the surface impedance in the regime of the anomalous skin effect in metals. This paper extends and complements an earlier analysis of B. Podobedov, Phys. Rev. ST Accel. Beams 12, 044401 (2009). into the region of very high frequencies associated with bunch lengths in the micron range. We study in detail the case of a rectangular bunch distribution for parameters of interest of LCLS-II with a superconducting undulator.

Markov models of genome segmentation

NASA Astrophysics Data System (ADS)

Thakur, Vivek; Azad, Rajeev K.; Ramaswamy, Ram

2007-01-01

We introduce Markov models for segmentation of symbolic sequences, extending a segmentation procedure based on the Jensen-Shannon divergence that has been introduced earlier. Higher-order Markov models are more sensitive to the details of local patterns and in application to genome analysis, this makes it possible to segment a sequence at positions that are biologically meaningful. We show the advantage of higher-order Markov-model-based segmentation procedures in detecting compositional inhomogeneity in chimeric DNA sequences constructed from genomes of diverse species, and in application to the E. coli K12 genome, boundaries of genomic islands, cryptic prophages, and horizontally acquired regions are accurately identified.

76 FR 20767 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

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Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... Extraordinary Market Volatility, To Extend the Effective Date of the Pilot Until the Earlier of August 11, 2011 or the Date on Which a Limit Up/Limit Down Mechanism To Address Extraordinary Market Volatility, if... due to extraordinary market volatility, to extend the effective date of the pilot by which such rule...

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Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... Volatility, To Extend the Effective Date of the Pilot Until the Earlier of August 11, 2011 or the Date on Which a Limit Up/Limit Down Mechanism To Address Extraordinary Market Volatility, If Adopted, Applies... due to extraordinary market volatility, to extend the effective date of the pilot by which such rule...

Complete convergence of randomly weighted END sequences and its application.

PubMed

Li, Penghua; Li, Xiaoqin; Wu, Kehan

2017-01-01

We investigate the complete convergence of partial sums of randomly weighted extended negatively dependent (END) random variables. Some results of complete moment convergence, complete convergence and the strong law of large numbers for this dependent structure are obtained. As an application, we study the convergence of the state observers of linear-time-invariant systems. Our results extend the corresponding earlier ones.

Public Law 96-374--Oct. 3, 1980. An Act to Amend and Extend the Higher Education Act of 1965, and for Other Purposes. 96th Congress.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC.

The text of the Education Amendments of 1980, which amend the Higher Education Act of 1965, is presented. It consists of 13 parts: (1) establishment of a new Title I of the earlier act, establishing new programs, continuing postsecondary education program and planning; (2) amendment and extension of Title II of the earlier act, college and…

Public Law 94-103: 94th Congress, H.R. 4005, October 4, 1975. An Act to Amend the Developmental Disabilities Services and Facilities Construction Act to Revise and Extend the Programs Authorized by that Act.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate.

Presented is the 1975 amendment to the Developmental Disabilities Services and Facilities Construction Act. Described are revisions and extensions of the earlier act, including revision of grant and construction assistance for university affiliated facilities, and revision of special projects assistance. The earlier act's designation of rights of…

Imbedded Nanocrystals of CsPbBr3 in Cs4 PbBr6 : Kinetics, Enhanced Oscillator Strength, and Application in Light-Emitting Diodes.

PubMed

Xu, Junwei; Huang, Wenxiao; Li, Peiyun; Onken, Drew R; Dun, Chaochao; Guo, Yang; Ucer, Kamil B; Lu, Chang; Wang, Hongzhi; Geyer, Scott M; Williams, Richard T; Carroll, David L

2017-11-01

Solution-grown films of CsPbBr 3 nanocrystals imbedded in Cs 4 PbBr 6 are incorporated as the recombination layer in light-emitting diode (LED) structures. The kinetics at high carrier density of pure (extended) CsPbBr 3 and the nanoinclusion composite are measured and analyzed, indicating second-order kinetics in extended and mainly first-order kinetics in the confined CsPbBr 3 , respectively. Analysis of absorption strength of this all-perovskite, all-inorganic imbedded nanocrystal composite relative to pure CsPbBr 3 indicates enhanced oscillator strength consistent with earlier published attribution of the sub-nanosecond exciton radiative lifetime in nanoprecipitates of CsPbBr 3 in melt-grown CsBr host crystals and CsPbBr 3 evaporated films. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Analytical model of chemical phase and formation of DSB in chromosomes by ionizing radiation.

PubMed

Barilla, Jiří; Lokajíček, Miloš; Pisaková, Hana; Simr, Pavel

2013-03-01

Mathematical analytical model of the processes running in individual radical clusters during the chemical phase (under the presence of radiomodifiers) proposed by us earlier has been further developed and improved. It has been applied to the data presented by Blok and Loman characterizing the oxygen effect in SSB and DSB formation (in water solution and at low-LET radiation) also in the region of very small oxygen concentrations, which cannot be studied with the help of experiments done with living cells. In this new analysis the values of all reaction rates and diffusion parameters known from literature have been made use of. The great increase of SSB and DSB at zero oxygen concentration may follow from the fact that at small oxygen concentrations the oxygen absorbs other radicals while at higher concentrations the formation of oxygen radicals prevails. It explains the double oxygen effect found already earlier by Ewing. The model may be easily extended to include also the effects of other radiomodifiers present in medium during irradiation.

Correlation mass method for analysis of neutrinos from supernova 1987A

NASA Technical Reports Server (NTRS)

Chiu, Hong-Yee; Chan, Kwing L.; Kondo, Yoji

1988-01-01

Application of a time-energy correlation method to the Kamiokande II (KII) observations of neutrinos apparently emitted from supernova 1987A has yielded a neutrino rest mass of 3.6 eV. A Monte Carlo analysis shows a reconfirming probabilty distribution for the neutrino rest mass peaked at 2.8, and dropping to 50 percent of the peak at 1.4 and 4.8 eV. Although the KII data indicate a very short time scale of emission, over an extended period on the order of 10 sec, both data from the Irvine-Michigan-Brookhaven experiment and the KII data show a tendency for the more energetic neutrinos to be emitted earlier at the source, suggesting the possibility of cooling.

Information Flow in Interaction Networks II: Channels, Path Lengths, and Potentials

PubMed Central

Stojmirović, Aleksandar

2012-01-01

Abstract In our previous publication, a framework for information flow in interaction networks based on random walks with damping was formulated with two fundamental modes: emitting and absorbing. While many other network analysis methods based on random walks or equivalent notions have been developed before and after our earlier work, one can show that they can all be mapped to one of the two modes. In addition to these two fundamental modes, a major strength of our earlier formalism was its accommodation of context-specific directed information flow that yielded plausible and meaningful biological interpretation of protein functions and pathways. However, the directed flow from origins to destinations was induced via a potential function that was heuristic. Here, with a theoretically sound approach called the channel mode, we extend our earlier work for directed information flow. This is achieved by constructing a potential function facilitating a purely probabilistic interpretation of the channel mode. For each network node, the channel mode combines the solutions of emitting and absorbing modes in the same context, producing what we call a channel tensor. The entries of the channel tensor at each node can be interpreted as the amount of flow passing through that node from an origin to a destination. Similarly to our earlier model, the channel mode encompasses damping as a free parameter that controls the locality of information flow. Through examples involving the yeast pheromone response pathway, we illustrate the versatility and stability of our new framework. PMID:22409812

Impact of 6-month earlier versus postponed initiation of rotigotine on long-term outcome: post hoc analysis of patients with early Parkinson's disease with mild symptom severity.

PubMed

Timmermann, Lars; Asgharnejad, Mahnaz; Boroojerdi, Babak; Dohin, Elisabeth; Woltering, Franz; Elmer, Lawrence W

2015-01-01

Investigate impact of 6-month earlier versus postponed initiation of rotigotine in patients with early Parkinson's disease (PD) with mild symptom severity. Long-term benefit of rotigotine in early-PD has been demonstrated: SP702 (NCT00594165) and SP716 (NCT00599196) were long-term, open-label extensions of double-blind, placebo-controlled studies of 6-month maintenance; rotigotine was well tolerated for up to 6 years, and demonstrated efficacy (Unified Parkinson's Disease Rating Scale [UPDRS] II + III below baseline) for ∼ 2 years (SP702) and ∼ 4 years (SP716). Post hoc analysis of patients at Hoehn and Yahr 1-2; groups defined by treatment received in 6-month double-blind studies: 'Rotigotine-Rotigotine' received rotigotine (n = 221), 'Placebo-Rotigotine' received placebo (n = 125). At the start of open-label rotigotine maintenance, UPDRS II + III mean ± SD change from double-blind baseline was: -8.5 ± 10.6 'Rotigotine-Rotigotine', -7.7 ± 9.0 'Placebo-Rotigotine.' After this initial improvement scores gradually increased: It took ∼ 45 months for mean scores to cross baseline in 'Rotigotine-Rotigotine', and ∼ 21 months in 'Placebo-Rotigotine.' At the time mean UPDRS II + III had crossed baseline in 'Placebo-Rotigotine' (open-label week 84; ∼ 21 months), treatment difference (LS-mean) to 'Rotigotine-Rotigotine' change from baseline was -3.89 (95% CI -6.94, -0.84); p = 0.013. In this post hoc analysis, 6-month earlier initiation of rotigotine resulted in slower return to baseline mean UPDRS II + III; initiation of rotigotine in patients with minimal/no functional disability or impairment may lead to an extended benefit.

Analysis of penetration and mixing of gas jets in supersonic cross flow

NASA Technical Reports Server (NTRS)

Billig, F. S.; Schetz, J. A.

1992-01-01

The JETPEN analysis for gas jets in a supersonic cross flow developed earlier at APL/JHU has been extended in several important ways. First, the treatment of cases with injection at angles other than 90 deg has been redone. Next, the second of the three regions formerly treated has been eliminated. Third, the region downstream of the Mach disk for underexpanded cases has been reformulated such that turbulent entrainment of main stream fluid into the plume is modeled, and the equations of motion are solved marching downstream. These changes now permit prediction of the variation in composition, mixing area growth and all other flow variables along the plume. The analysis has been verified by comparison of predictions and experiment over a wide range of conditions. The result is an analysis capable of reliable predictions of the major flowfield variables that can be run on a PC.

Reliability Analysis for AFTI-F16 SRFCS Using ASSIST and SURE

NASA Technical Reports Server (NTRS)

Wu, N. Eva

2001-01-01

This paper reports the results of a study on reliability analysis of an AFTI-16 Self-Repairing Flight Control System (SRFCS) using software tools SURE (Semi-Markov Unreliability Range Evaluator and ASSIST (Abstract Semi-Markov Specification Interface to the SURE Tool). The purpose of the study is to investigate the potential utility of the software tools in the ongoing effort of the NASA Aviation Safety Program, where the class of systems must be extended beyond the originally intended serving class of electronic digital processors. The study concludes that SURE and ASSIST are applicable to reliability, analysis of flight control systems. They are especially efficient for sensitivity analysis that quantifies the dependence of system reliability on model parameters. The study also confirms an earlier finding on the dominant role of a parameter called a failure coverage. The paper will remark on issues related to the improvement of coverage and the optimization of redundancy level.

Remembering others: using life scripts to access positive but not negative information.

PubMed

White, Hedy; Coppola, Harmony A; Multunas, Nichole K

2008-01-01

The current research extended to memories of others the life script theory of abstract, idealized mental representations of transitional experiences. Recent and earlier high school graduates rated positive and negative characteristics of popular, average, and unpopular girls from their schools. "Average" girls were rated as higher than average on possessing positive characteristics. Recent but not earlier graduates distinguished between popularity conditions on negative characteristics (negative information is not included in life scripts). For positive characteristics, earlier graduates remembered unpopular girls less favorably (perhaps using stereotypical scripts) than recent graduates remembered them (having greater access to episodic memories of individual girls). A smaller graduation time difference in the same direction resulted for average and popular girls.

On certain subclasses of multivalent functions associated with an extended fractional differintegral operator

NASA Astrophysics Data System (ADS)

Patel, J.; Mishra, A. K.

2007-08-01

In the present paper an extended fractional differintegral operator , suitable for the study of multivalent functions is introduced. Various mapping properties and inclusion relationships between certain subclasses of multivalent functions are investigated by applying the techniques of differential subordination. Relevant connections of the definitions and results presented in this paper with those obtained in several earlier works on the subject are also pointed out.

Numerical analysis of the asymptotic two-point boundary value solution for N-body trajectories.

NASA Technical Reports Server (NTRS)

Lancaster, J. E.; Allemann, R. A.

1972-01-01

Previously published asymptotic solutions for lunar and interplanetary trajectories have been modified and combined to formulate a general analytical boundary value solution applicable to a broad class of trajectory problems. In addition, the earlier first-order solutions have been extended to second-order to determine if improved accuracy is possible. Comparisons between the asymptotic solution and numerical integration for several lunar and interplanetary trajectories show that the asymptotic solution is generally quite accurate. Also, since no iterations are required, a solution to the boundary value problem is obtained in a fraction of the time required for numerically integrated solutions.

New results on global exponential dissipativity analysis of memristive inertial neural networks with distributed time-varying delays.

PubMed

Zhang, Guodong; Zeng, Zhigang; Hu, Junhao

2018-01-01

This paper is concerned with the global exponential dissipativity of memristive inertial neural networks with discrete and distributed time-varying delays. By constructing appropriate Lyapunov-Krasovskii functionals, some new sufficient conditions ensuring global exponential dissipativity of memristive inertial neural networks are derived. Moreover, the globally exponential attractive sets and positive invariant sets are also presented here. In addition, the new proposed results here complement and extend the earlier publications on conventional or memristive neural network dynamical systems. Finally, numerical simulations are given to illustrate the effectiveness of obtained results. Copyright © 2017 Elsevier Ltd. All rights reserved.

Happiest People Revisited.

PubMed

Diener, Ed; Seligman, Martin E P; Choi, Hyewon; Oishi, Shigehiro

2018-03-01

In a past Psychological Science article, Diener and Seligman (2002) explored the characteristics of extremely happy individuals and found that strong social relationships characterized the entire group. The study was popular, perhaps because the authors focused on the very happiest people, not merely on correlations across the entire spectrum of subjective well-being. In the current study, we replicated and extended the earlier paper here by examining, in a world sample, the differences between the happiest individuals and unhappy and averagely happy people. We largely replicated earlier findings; basic need fulfillment and social resources were two ingredients for high subjective well-being. Replicating and extending the earlier findings, we found that, compared with the averagely happy people, the happiest people were more likely to come from societies high in subjective well-being and social capital. To achieve very high happiness, it is helpful not only to have desirable personal circumstances, but also to live in a prosperous happy society with strong social support. As in the original study, although a few characteristics seemed virtually necessary for subjective well-being (SWB), no characteristic guaranteed it. We also uncovered variables separating the groups that might be outcomes of SWB, for example, helping others, exercising, and not smoking.

Beyond the double banana: improved recognition of temporal lobe seizures in long-term EEG.

PubMed

Rosenzweig, Ivana; Fogarasi, András; Johnsen, Birger; Alving, Jørgen; Fabricius, Martin Ejler; Scherg, Michael; Neufeld, Miri Y; Pressler, Ronit; Kjaer, Troels W; van Emde Boas, Walter; Beniczky, Sándor

2014-02-01

To investigate whether extending the 10-20 array with 6 electrodes in the inferior temporal chain and constructing computed montages increases the diagnostic value of ictal EEG activity originating in the temporal lobe. In addition, the accuracy of computer-assisted spectral source analysis was investigated. Forty EEG samples were reviewed by 7 EEG experts in various montages (longitudinal and transversal bipolar, common average, source derivation, source montage, current source density, and reference-free montages) using 2 electrode arrays (10-20 and the extended one). Spectral source analysis used source montage to calculate density spectral array, defining the earliest oscillatory onset. From this, phase maps were calculated for localization. The reference standard was the decision of the multidisciplinary epilepsy surgery team on the seizure onset zone. Clinical performance was compared with the double banana (longitudinal bipolar montage, 10-20 array). Adding the inferior temporal electrode chain, computed montages (reference free, common average, and source derivation), and voltage maps significantly increased the sensitivity. Phase maps had the highest sensitivity and identified ictal activity at earlier time-point than visual inspection. There was no significant difference concerning specificity. The findings advocate for the use of these digital EEG technology-derived analysis methods in clinical practice.

A Time Series Analysis of Cancer-Related Information Seeking: Hints From the Health Information National Trends Survey (HINTS) 2003-2014.

PubMed

Huerta, Timothy R; Walker, Daniel M; Johnson, Tyler; Ford, Eric W

2016-09-01

Recent technological changes, such as the growth of the Internet, have made cancer information widely available. However, it remains unknown whether changes in access have resulted in concomitant changes in information seeking behavior. Previous work explored the cancer information seeking behaviors of the general population using the 2003 Health Information National Trends Survey (HINTS). This article aims to reproduce, replicate, and extend that existing analysis using the original dataset and five additional iterations of HINTS (2007, 2011, 2012, 2013, 2014). This approach builds on the earlier work by quantifying the magnitude of change in information seeking behaviors. Bivariate comparison of the 2003 and 2014 data revealed very similar results; however, the multivariate model including all years of data indicated differences between the original and extended models: individuals age 65 and older were no longer less likely to seek cancer information than the 18-35 reference population, and Hispanics were also no longer less likely to be cancer information seekers. The results of our analysis indicate an overall shift in cancer information seeking behaviors and also illuminate the impact of increased Internet usage over the past decade, suggesting specific demographic groups that may benefit from cancer information seeking encouragement.

Periodic intensity variations in sulfur emissions from the Io plasma torus

NASA Technical Reports Server (NTRS)

Woodward, R. Carey, Jr.; Scherb, Frank; Roesler, Fred L.

1994-01-01

In November and December 1988, we acquired 157 spectra of (S II) lambda 6731 emissions from the Io plasma torus with a Fabry-Perot interferometer at the McMath-Pierce Solar Telescope facility on Kitt Peak. A major goal of this experiment was to extend our earlier studies of intensity variations in the plasma torus. Our earlier analysis (F. L. Roesler, F. Scherb, and R. J. Oliversen, 1984, of (S III) lambda 9531 emission spectra acquired in April 1982 had shown that the intensity of torus emissions varied periodically with a period of 10.20 +/- 0.06 hr (1-sigma uncertainty level), slightly longer than Jupiter's System 3 rotational period of 9.925 hr. We present here an reanalysis of our 1982 data revealing, in addition to the 10.20-hr period, a clear secondary periodicity at 9.95 +/- 0.906 hr. By constrast, we show that our new (S II) lambda 6731 data have a single period of 10.14 +/- 0.03 hr. which is neither the System 3 period nor the proposed 'System 4' period of 10.224 hr.

Periodic intensity variations in sulfur emissions from the Io plasma torus

NASA Astrophysics Data System (ADS)

Woodward, R. Carey, Jr.; Scherb, Frank; Roesler, Fred L.; Oliversen, Ronald J.

1994-09-01

In November and December 1988, we acquired 157 spectra of (S II) lambda 6731 emissions from the Io plasma torus with a Fabry-Perot interferometer at the McMath-Pierce Solar Telescope facility on Kitt Peak. A major goal of this experiment was to extend our earlier studies of intensity variations in the plasma torus. Our earlier analysis (F. L. Roesler, F. Scherb, and R. J. Oliversen, 1984, of (S III) lambda 9531 emission spectra acquired in April 1982 had shown that the intensity of torus emissions varied periodically with a period of 10.20 +/- 0.06 hr (1-sigma uncertainty level), slightly longer than Jupiter's System 3 rotational period of 9.925 hr. We present here an reanalysis of our 1982 data revealing, in addition to the 10.20-hr period, a clear secondary periodicity at 9.95 +/- 0.906 hr. By constrast, we show that our new (S II) lambda 6731 data have a single period of 10.14 +/- 0.03 hr. which is neither the System 3 period nor the proposed 'System 4' period of 10.224 hr.

Comparison of North and South American biomes from AVHRR observations

NASA Technical Reports Server (NTRS)

Goward, Samuel N.; Dye, Dennis; Kerber, Arlene; Kalb, Virginia

1987-01-01

Previous analysis of the North American continent with AVHRR-derived vegetation index measurements showed a strong relation between known patterns of vegetation seasonality, productivity and the spectral vegetation index measurements. This study extends that analysis to South America to evaluate the degree to which these findings extend to tropical regions. The results show that the spectral vegetation index measurements provide a general indicator of vegetation activity across the major biomes of the Western Hemisphere of the earth, including tropical regions. The satellite-observed patterns are strongly related to the known climatology of the continents and may offer a means to improve understanding of global bioclimatology. For example, South America is shown to have a longer growing season with much earlier spring green-up than North America. The time integral of the measurements, computed from 12 composited monthly values, produces a value that is related to published net primary productivity data. However, limited net primary production data does not allow complete evaluation of satellite-observed contrasts between North and South American biomes. These results suggest that satellite-derived spectral vegetation index measurements are of great potential value in improving knowledge of the earth's biosphere.

Dietary restriction of rodents decreases aging rate without affecting initial mortality rate -- a meta-analysis.

PubMed

Simons, Mirre J P; Koch, Wouter; Verhulst, Simon

2013-06-01

Dietary restriction (DR) extends lifespan in multiple species from various taxa. This effect can arise via two distinct but not mutually exclusive ways: a change in aging rate and/or vulnerability to the aging process (i.e. initial mortality rate). When DR affects vulnerability, this lowers mortality instantly, whereas a change in aging rate will gradually lower mortality risk over time. Unraveling how DR extends lifespan is of interest because it may guide toward understanding the mechanism(s) mediating lifespan extension and also has practical implications for the application of DR. We reanalyzed published survival data from 82 pairs of survival curves from DR experiments in rats and mice by fitting Gompertz and also Gompertz-Makeham models. The addition of the Makeham parameter has been reported to improve the estimation of Gompertz parameters. Both models separate initial mortality rate (vulnerability) from an age-dependent increase in mortality (aging rate). We subjected the obtained Gompertz parameters to a meta-analysis. We find that DR reduced aging rate without affecting vulnerability. The latter contrasts with the conclusion of a recent analysis of a largely overlapping data set, and we show how the earlier finding is due to a statistical artifact. Our analysis indicates that the biology underlying the life-extending effect of DR in rodents likely involves attenuated accumulation of damage, which contrasts with the acute effect of DR on mortality reported for Drosophila. Moreover, our findings show that the often-reported correlation between aging rate and vulnerability does not constrain changing aging rate without affecting vulnerability simultaneously. © 2013 John Wiley & Sons Ltd and the Anatomical Society.

Agent based reasoning for the non-linear stochastic models of long-range memory

NASA Astrophysics Data System (ADS)

Kononovicius, A.; Gontis, V.

2012-02-01

We extend Kirman's model by introducing variable event time scale. The proposed flexible time scale is equivalent to the variable trading activity observed in financial markets. Stochastic version of the extended Kirman's agent based model is compared to the non-linear stochastic models of long-range memory in financial markets. The agent based model providing matching macroscopic description serves as a microscopic reasoning of the earlier proposed stochastic model exhibiting power law statistics.

OOPs!

ERIC Educational Resources Information Center

Margush, Tim

2001-01-01

Discussion of Object Oriented Programming (OOP) focuses on criticism of an earlier article that addressed problems of applying specific functionality to controls across several forms in a Visual Basic project. Examines the Object Oriented techniques, inheritance and composition, commonly employed to extend the functionality of an object.…

The polarization observables T, P, and H and their impact on γp → pπ0 multipoles

NASA Astrophysics Data System (ADS)

Hartmann, J.; Dutz, H.; Anisovich, A. V.; Bayadilov, D.; Beck, R.; Becker, M.; Beloglazov, Y.; Berlin, A.; Bichow, M.; Böse, S.; Brinkmann, K.-Th.; Crede, V.; Dieterle, M.; Eberhardt, H.; Elsner, D.; Fornet-Ponse, K.; Friedrich, St.; Frommberger, F.; Funke, Ch.; Gottschall, M.; Gridnev, A.; Grüner, M.; Goertz, St.; Gutz, E.; Hammann, Ch.; Hannappel, J.; Hannen, V.; Herick, J.; Hillert, W.; Hoffmeister, Ph.; Honisch, Ch.; Jahn, O.; Jude, T.; Käser, A.; Kaiser, D.; Kalinowsky, H.; Kalischewski, F.; Klassen, P.; Keshelashvili, I.; Klein, F.; Klempt, E.; Koop, K.; Krusche, B.; Kube, M.; Lang, M.; Lopatin, I.; Makonyi, K.; Messi, F.; Metag, V.; Meyer, W.; Müller, J.; Nanova, M.; Nikonov, V.; Novinski, D.; Novotny, R.; Piontek, D.; Reeve, S.; Rosenbaum, Ch.; Roth, B.; Reicherz, G.; Rostomyan, T.; Runkel, St.; Sarantsev, A.; Schmidt, Ch.; Schmieden, H.; Schmitz, R.; Seifen, T.; Sokhoyan, V.; Thämer, Ph.; Thiel, A.; Thoma, U.; Urban, M.; van Pee, H.; Walther, D.; Wendel, Ch.; Wiedner, U.; Wilson, A.; Winnebeck, A.; Witthauer, L.

2015-09-01

Data on the polarization observables T, P, and H for the reaction γp → pπ0 are reported. Compared to earlier data from other experiments, our data are more precise and extend the covered range in energy and angle substantially. The results were extracted from azimuthal asymmetries measured using a transversely polarized target and linearly polarized photons. The data were taken at the Bonn electron stretcher accelerator ELSA with the CBELSA/TAPS detector. Within the Bonn-Gatchina partial wave analysis, the new polarization data lead to a significant narrowing of the error band for the multipoles for neutral-pion photoproduction.

Testing the robustness of the diagnostic overshadowing bias.

PubMed

Spengler, P M; Strohmer, D C; Prout, H T

1990-09-01

The robustness of the diagnostic overshadowing bias was examined by (a) testing the relation of overshadowing to level of mental retardation, (b) reexamining the effect of clinical experience in a more sensitive analysis, and (c) extending previous results to rehabilitation counselors. Diagnostic overshadowing was found with individuals with an IQ of 58, but did not generalize to those with IQs 70 or 80. This finding does not support the saliency hypothesis proposed by Reiss and his colleagues. In contrast to earlier studies, experience was related to overshadowing, although results were mixed. Experience measured by number of clients seen was not significant, whereas longevity in the field of mental retardation was associated with increased overshadowing.

Seasonal-to-Interannual Precipitation Variability and Predictability in a Coupled Land-Atmosphere System

NASA Technical Reports Server (NTRS)

Koster, Randal D.; Suarez, M. J.; Heiser, M.

1998-01-01

In an earlier GCM study, we showed that interactive land surface processes generally contribute more to continental precipitation variance than do variable sea surface temperatures (SSTs). A new study extends this result through an analysis of 16-member ensembles of multi-decade GCM simulations. We can now show that in many regions, although land processes determine the amplitude of the interannual precipitation anomalies, variable SSTs nevertheless control their timing. The GCM data can be processed into indices that describe geographical variations in (1) the potential for seasonal-to-interannual prediction, and (2) the extent to which the predictability relies on the proper representation of land-atmosphere feedback.

A new class of problems in the calculus of variations

NASA Astrophysics Data System (ADS)

Ekeland, Ivar; Long, Yiming; Zhou, Qinglong

2013-11-01

This paper investigates an infinite-horizon problem in the one-dimensional calculus of variations, arising from the Ramsey model of endogeneous economic growth. Following Chichilnisky, we introduce an additional term, which models concern for the well-being of future generations. We show that there are no optimal solutions, but that there are equilibrium strateges, i.e. Nash equilibria of the leader-follower game between successive generations. To solve the problem, we approximate the Chichilnisky criterion by a biexponential criterion, we characterize its equilibria by a pair of coupled differential equations of HJB type, and we go to the limit. We find all the equilibrium strategies for the Chichilnisky criterion. The mathematical analysis is difficult because one has to solve an implicit differential equation in the sense of Thom. Our analysis extends earlier work by Ekeland and Lazrak.

LDEF systems special investigation group overview

NASA Technical Reports Server (NTRS)

Mason, Jim; Dursch, Harry

1995-01-01

The Systems Special Investigation Group (Systems SIG), formed by the LDEF Project Office to perform post-flight analysis of LDEF systems hardware, was chartered to investigate the effects of the extended LDEF mission on both satellite and experiment systems and to coordinate and integrate all systems related analyses performed during post-flight investigations. The Systems SIG published a summary report in April, 1992 titled 'Analysis of Systems Hardware Flown on LDEF - Results of the Systems Special Investigation Group' that described findings through the end of 1991. The Systems SIG, unfunded in FY 92 and FY93, has been funded in FY 94 to update this report with all new systems related findings. This paper provides a brief summary of the highlights of earlier Systems SIG accomplishments and describes tasks the Systems SIG has been funded to accomplish in FY 94.

Compositional partitioning during the spinodal decomposition in Cu-Ni-Sn alloy

NASA Astrophysics Data System (ADS)

Basak, C. B.; Poswal, A. K.

2018-05-01

Spinodal decomposition in Cu-9.4at%Ni-3.1at%Sn alloy was elucidated with the new insight from the experimental EXAFS analysis supported by ab initio total energy calculations suggesting the strong influence of the first near-neighbour atoms. Enthalpy of mixing was calculated for all crystallographically unique first near-neighbour configurations and finally an average positive enthalpy of mixing of 1604 J/mol was obtained. Combination of ab initio results, XRD and EXAFS analysis indicate that one of the daughter phase becomes rich in Ni and Sn than the other phase; in contrary to the earlier proposition that Cu/Ni ratio remains constant in both daughter phases. It is also shown that the present thermodynamic description requires further refinement to extend the miscibility gap towards lower Ni content in Cu-Ni-Sn system.

Erickson and Rogers: The Differences Do Make a Difference.

ERIC Educational Resources Information Center

Lopez, Frederick G.

1987-01-01

Extends an earlier discussion by Gunnison (1985) of the similarities between Milton Erickson and Carl Rogers by citing several important differences in their respective counseling approaches. Briefly discusses implications of these differences to the continuing evolution of counseling theory and practice. (Author)

Advanced Microstrip Antenna Developments : Volume I. Technology Studies for Aircraft Phased Arrays

DOT National Transportation Integrated Search

1981-06-01

Work has continued on improvement of microstrip phased-array antenna technology since the first microstrip phased-array was flight-tested during the FAA 1974-1975 ATS-6 test program. The present development has extended this earlier work in three are...

Immunological Consequences of Maternal Separation in Infant Primates.

ERIC Educational Resources Information Center

Coe, Christopher L.; And Others

1989-01-01

Reports recent studies which establish that maternal separation and early rearing conditions can influence the development and expression of immune responses of the primate infant. Current findings extend an earlier finding on alterations in lymphocyte proliferation responses to a number of other immune parameters. (NH)

A Formal Theory for Modular ERDF Ontologies

NASA Astrophysics Data System (ADS)

Analyti, Anastasia; Antoniou, Grigoris; Damásio, Carlos Viegas

The success of the Semantic Web is impossible without any form of modularity, encapsulation, and access control. In an earlier paper, we extended RDF graphs with weak and strong negation, as well as derivation rules. The ERDF #n-stable model semantics of the extended RDF framework (ERDF) is defined, extending RDF(S) semantics. In this paper, we propose a framework for modular ERDF ontologies, called modular ERDF framework, which enables collaborative reasoning over a set of ERDF ontologies, while support for hidden knowledge is also provided. In particular, the modular ERDF stable model semantics of modular ERDF ontologies is defined, extending the ERDF #n-stable model semantics. Our proposed framework supports local semantics and different points of view, local closed-world and open-world assumptions, and scoped negation-as-failure. Several complexity results are provided.

Treatment decisions and the impact of adverse events before and during extended endocrine therapy in postmenopausal early breast cancer.

PubMed

Blok, Erik J; Kroep, Judith R; Meershoek-Klein Kranenbarg, Elma; Duijm-de Carpentier, Marjolijn; Putter, Hein; Liefers, Gerrit-Jan; Nortier, Johan W R; Rutgers, Emiel J Th; Seynaeve, Caroline M; van de Velde, Cornelis J H

2018-05-01

Extended endocrine therapy beyond 5 years for postmenopausal breast cancer has been studied within multiple phase III trials. Treatment compliance in these trials is generally poor. In this analysis, we aimed to determine factors that were associated with participation in the phase III Investigation on the Duration of Extended Adjuvant Letrozole (IDEAL) trial and with early treatment discontinuation, and how this influenced survival outcome. In the IDEAL trial, postmenopausal patients were randomised between 2.5 or 5 years of extended letrozole, after completing 5 years of endocrine therapy for hormone receptor-positive early breast cancer. A subgroup of this population participated earlier in the Tamoxifen Exemestane Adjuvant Multinational trial (5 years of exemestane or 2.5 years of tamoxifen followed by exemestane as primary adjuvant therapy) in which we explored which factors were determinative for enrolment in the IDEAL study. In the IDEAL cohort, we evaluated which factors predicted for early treatment discontinuation and the effect of early treatment discontinuation on disease-free survival (DFS). Nodal status, younger age and adjuvant chemotherapy were significantly associated with higher enrolment in the IDEAL trial. In the IDEAL cohort, adverse events (AEs), the type of primary endocrine therapy and the interval between primary and extended therapy were associated with early treatment discontinuation. Among the reported AEs, depressive feelings (56%) were most frequently associated with early treatment discontinuation. Early treatment discontinuation was not associated with worse DFS (hazard ratio [HR] = 1.02, 95% confidence interval = 0.76-1.37). In this analysis, we found that risk factors were most strongly associated enrolment in the IDEAL trial. In contrast, patient experiences were the most significant factors leading to early treatment discontinuation, with no effect on DFS. Copyright © 2018 Elsevier Ltd. All rights reserved.

Concreteness Effects in Text Recall: Dual Coding or Context Availability?

ERIC Educational Resources Information Center

Sadoski, Mark; And Others

1995-01-01

Extends an earlier study by using different materials, ratings for familiarity, and more stringent experimental controls. Finds concreteness effects in two experiments using undergraduate students. Suggests that familiarity and concreteness contribute separately to recall. Supports a dual coding theory. Discusses implications for text design. (RS)

Prejudice against Cigarette Smokers in Higher Education.

ERIC Educational Resources Information Center

Venuti, John Paul; Conroy, Matthew; Bucy, Paige; Landis, Pamela L.; Chambliss, Catherine

This study extends earlier work (Campbell, et al., 2000) which documented discriminatory attitudes towards college students who smoke by exploring personality stereotypes associated with student smoking, using a sample of students (N=222) from the Northeastern United States and Australia. Findings of this study corroborate those of other…

Special Education Teachers Integrating Reading with 8th Grade U.S. History Content

ERIC Educational Resources Information Center

O'Connor, Rollanda E.; Sanchez, Victoria; Beach, Kristen D.; Bocian, Kathleen M.

2017-01-01

This research replicates an earlier study (O'Connor, Beach, Sanchez, Bocian, & Flynn, 2015) and extends it by shifting instructional responsibility from researchers to special education teachers, who implemented reading instruction that included multisyllabic word decoding, academic vocabulary, and three comprehension strategies (generating…

Context-Based Assessment: Creating Opportunities for Resonance between Classroom Fields and Societal Fields

ERIC Educational Resources Information Center

Bellocchi, Alberto; King, Donna T.; Ritchie, Stephen M.

2016-01-01

There is on-going international interest in the relationships between assessment instruments, students' understanding of science concepts and context-based curriculum approaches. This study extends earlier research showing that students can develop connections between contexts and concepts--called "fluid transitions"--when studying…

Defensive Stakeholder Management in European Universities: An Institutional Logics Perspective

ERIC Educational Resources Information Center

Mampaey, Jelle; Huisman, Jeroen

2016-01-01

Earlier studies on stakeholder management in European universities focused on proactive strategies, that is, substantive organizational practices to establish and maintain mutually beneficial exchanges between universities and their stakeholders. We argue that the literature on stakeholder management has to be extended by theorizing defensive…

Job loss, human capital job feature, and work condition job feature as distinct job insecurity constructs.

PubMed

Blau, Gary; Tatum, Donna Surges; McCoy, Keith; Dobria, Lidia; Ward-Cook, Kory

2004-01-01

The projected growth of new technologies, increasing use of automation, and continued consolidation of health-related services suggest that continued study of job insecurity is needed for health care professionals. Using a sample of 178 medical technologists over a 5-year period, this study's findings extend earlier work by Blau and Sharp (2000) and suggest that job loss insecurity, human capital job feature insecurity, and work condition job feature insecurity are related but distinct types of job insecurity. A seven-item measure of job loss insecurity, a four-item measure of human capital job feature insecurity, and a four-item measure of work condition job feature insecurity were analyzed. Confirmatory factor analysis using a more heterogeneous sample of 447 working adults supported this three-factor structure. Using correlation and path analysis, different significant relationships of antecedent variables and subsequent organizational withdrawal cognitions to these three types of job insecurity were found.

Beyond mean-field effects in Bloch Oscillations of cold atoms in an optical cavity

NASA Astrophysics Data System (ADS)

Venkatesh Balasubramanian, Prasanna; O'Dell, Duncan

2012-06-01

In our earlier publication [1] we proposed using Bloch oscillations of cold atoms inside an Fabry-Perot resonator for sensitive measurements of force. The analysis in [1] was performed using a coherent mean-field description for the atoms and the light. In the current work we extend this description substantially by including the effects of fluctuations in both the atomic and light fields. This analysis is used to set realistic limits on the precision to which the force can be measured. We also make contact with the optomechanical description of the combined atom-cavity system which has proved so successful for describing recent pioneering experiments [2].[4pt] [1] B. Prasanna Venkatesh et al, Phys. Rev. A 80, 063834 (2009).[0pt] [2] S. Gupta et al, Phys. Rev. Lett. 99, 213601 (2007); F.Brennecke et al, Science 322, 235 (2008).

Geographically selective assortment of cycles in pandemics: meta-analysis of data collected by Chizhevsky.

PubMed

Gumarova, L; Cornélissen, G; Hillman, D; Halberg, F

2013-10-01

In the incidence patterns of cholera, diphtheria and croup during the past when they were of epidemic proportions, we document a set of cycles (periods), one of which was reported and discussed by A. L. Chizhevsky in the same data with emphasis on the mirroring in human disease of the ~11-year sunspot cycle. The data in this study are based on Chizhevsky’s book The Terrestrial Echo of Solar Storms and on records from the World Health Organization. For meta-analysis, we used the extended linear and nonlinear cosinor. We found a geographically selective assortment of various cycles characterizing the epidemiology of infections, which is the documented novel topic of this paper, complementing the earlier finding in the 21st century or shortly before, of a geographically selective assortment of cycles characterizing human sudden cardiac death. Solar effects, if any, interact with geophysical processes in contributing to this assortment.

Hydrogen Exchange and Mass Spectrometry: A Historical Perspective

PubMed Central

Englander, S. Walter

2012-01-01

Protein molecules naturally emit streams of information-rich signals in the language of hydrogen exchange concerning the intimate details of their stability, dynamics, function, changes therein, and effects thereon, all resolved to the level of their individual amino acids. The effort to measure protein hydrogen exchange behavior, understand the underlying chemistry and structural physics of hydrogen exchange processes, and use this information to learn about protein properties and function has continued for 50 years. Recent work uses mass spectrometric analysis together with an earlier proteolytic fragmentation method to extend the hydrogen exchange capability to large biologically interesting proteins. This article briefly reviews the advances that have led us to this point and the understanding that has so far been achieved. PMID:16876429

Spatiotemporal relations of primary sensorimotor and secondary motor activation patterns mapped by NIR imaging

PubMed Central

Khan, Bilal; Chand, Pankaj; Alexandrakis, George

2011-01-01

Functional near infrared (fNIR) imaging was used to identify spatiotemporal relations between spatially distinct cortical regions activated during various hand and arm motion protocols. Imaging was performed over a field of view (FOV, 12 x 8.4 cm) including the secondary motor, primary sensorimotor, and the posterior parietal cortices over a single brain hemisphere. This is a more extended FOV than typically used in current fNIR studies. Three subjects performed four motor tasks that induced activation over this extended FOV. The tasks included card flipping (pronation and supination) that, to our knowledge, has not been performed in previous functional magnetic resonance imaging (fMRI) or fNIR studies. An earlier rise and a longer duration of the hemodynamic activation response were found in tasks requiring increased physical or mental effort. Additionally, analysis of activation images by cluster component analysis (CCA) demonstrated that cortical regions can be grouped into clusters, which can be adjacent or distant from each other, that have similar temporal activation patterns depending on whether the performed motor task is guided by visual or tactile feedback. These analyses highlight the future potential of fNIR imaging to tackle clinically relevant questions regarding the spatiotemporal relations between different sensorimotor cortex regions, e.g. ones involved in the rehabilitation response to motor impairments. PMID:22162826

An extended theory of thin airfoils and its application to the biplane problem

NASA Technical Reports Server (NTRS)

Millikan, Clark B

1931-01-01

The report presents a new treatment, due essentially to von Karman, of the problem of the thin airfoil. The standard formulae for the angle of zero lift and zero moment are first developed and the analysis is then extended to give the effect of disturbing or interference velocities, corresponding to an arbitrary potential flow, which are superimposed on a normal rectilinear flow over the airfoil. An approximate method is presented for obtaining the velocities induced by a 2-dimensional airfoil at a point some distance away. In certain cases this method has considerable advantage over the simple "lifting line" procedure usually adopted. The interference effects for a 2-dimensional biplane are considered in the light of the previous analysis. The results of the earlier sections are then applied to the general problem of the interference effects for a 3-dimensional biplane, and formulae and charts are given which permit the characteristics of the individual wings of an arbitrary biplane without sweepback or dihedral to be calculated. In the final section the conclusions drawn from the application of the theory to a considerable number of special cases are discussed, and curves are given illustrating certain of these conclusions and serving as examples to indicate the nature of the agreement between the theory and experiment.

Design and Test of an Improved Crashworthiness Small Composite Airframe

NASA Technical Reports Server (NTRS)

Terry, James E.; Hooper, Steven J.; Nicholson, Mark

2002-01-01

The purpose of this small business innovative research (SBIR) program was to evaluate the feasibility of developing small composite airplanes with improved crashworthiness. A combination of analysis and half scale component tests were used to develop an energy absorbing airframe. Four full scale crash tests were conducted at the NASA Impact Dynamics Research Facility, two on a hard surface and two onto soft soil, replicating earlier NASA tests of production general aviation airplanes. Several seat designs and restraint systems including both an air bag and load limiting shoulder harnesses were tested. Tests showed that occupant loads were within survivable limits with the improved structural design and the proper combination of seats and restraint systems. There was no loss of cabin volume during the events. The analysis method developed provided design guidance but time did not allow extending the analysis to soft soil impact. This project demonstrated that survivability improvements are possible with modest weight penalties. The design methods can be readily applied by airplane designers using the examples in this report.

[Comparative analysis of variable regions in the genomes of variola virus].

PubMed

Babkin, I V; Nepomniashchikh, T S; Maksiutov, R A; Gutorov, V V; Babkina, I N; Shchelkunov, S N

2008-01-01

Nucleotide sequences of two extended segments of the terminal variable regions in variola virus genome were determined. The size of the left segment was 13.5 kbp and of the right, 10.5 kbp. Totally, over 540 kbp were sequenced for 22 variola virus strains. The conducted phylogenetic analysis and the data published earlier allowed us to find the interrelations between 70 variola virus isolates, the character of their clustering, and the degree of intergroup and intragroup variations of the clusters of variola virus strains. The most polymorphic loci of the genome segments studied were determined. It was demonstrated that that these loci are localized to either noncoding genome regions or to the regions of destroyed open reading frames, characteristic of the ancestor virus. These loci are promising for development of the strategy for genotyping variola virus strains. Analysis of recombination using various methods demonstrated that, with the only exception, no statistically significant recombinational events in the genomes of variola virus strains studied were detectable.

Comparison of Total Solar Irradiance with NASA/NSO Spectromagnetograph Data in Solar Cycles 22 and 23

NASA Technical Reports Server (NTRS)

Jones, Harrison P.; Branston, Detrick D.; Jones, Patricia B.; Popescu, Miruna D.

2002-01-01

An earlier study compared NASA/NSO Spectromagnetograph (SPM) data with spacecraft measurements of total solar irradiance (TSI) variations over a 1.5 year period in the declining phase of solar cycle 22. This paper extends the analysis to an eight-year period which also spans the rising and early maximum phases of cycle 23. The conclusions of the earlier work appear to be robust: three factors (sunspots, strong unipolar regions, and strong mixed polarity regions) describe most of the variation in the SPM record, but only the first two are associated with TSI. Additionally, the residuals of a linear multiple regression of TSI against SPM observations over the entire eight-year period show an unexplained, increasing, linear time variation with a rate of about 0.05 W m(exp -2) per year. Separate regressions for the periods before and after 1996 January 01 show no unexplained trends but differ substantially in regression parameters. This behavior may reflect a solar source of TSI variations beyond sunspots and faculae but more plausibly results from uncompensated non-solar effects in one or both of the TSI and SPM data sets.

Observed light yield of scintillation pixels: Extending the two-ray model

NASA Astrophysics Data System (ADS)

Kantorski, Igor; Jurkowski, Jacek; Drozdowski, Winicjusz

2016-09-01

In this paper we propose an extended, two dimensional model describing the propagation of scintillation photons inside a cuboid crystal until they reach a PMT window. In the simplest approach the model considers two main reasons for light losses: standard absorption obeying the classical Lambert-Beer law and non-ideal reflectivity of the "mummy" covering formed by several layers of Teflon tape wrapping the sample. Results of the model calculations are juxtaposed with experimental data as well as with predictions of an earlier, one dimensional model.

Family Factors and Student Outcomes. PRGS Dissertation

ERIC Educational Resources Information Center

Xia, Nailing

2010-01-01

There is considerable debate about the relative importance of family versus school factors in producing academic and nonacademic student outcomes, and whether and how their impacts vary across different student groups. In addition to critically reviewing and synthesizing earlier work, this study extends the literature by (a) using the ECLS-K, a…

12 CFR 403.5 - Declassification and downgrading.

Code of Federal Regulations, 2012 CFR

2012-01-01

... classification markings shall be lined through a statement placed on the cover or first page to indicate the... markings on each page shall be cancelled; otherwise, the statement on the cover or first page shall... taken earlier than originally scheduled, or the duration of classification is extended, the authority...

12 CFR 403.5 - Declassification and downgrading.

Code of Federal Regulations, 2011 CFR

2011-01-01

... classification markings shall be lined through a statement placed on the cover or first page to indicate the... markings on each page shall be cancelled; otherwise, the statement on the cover or first page shall... taken earlier than originally scheduled, or the duration of classification is extended, the authority...

The Vulnerability Framework Integrates Various Models of Generating Surplus Revenue

ERIC Educational Resources Information Center

Maniaci, Vincent

2004-01-01

Budgets operationalize the strategic planning process, and institutions must have surplus revenue to be able to cope with future operations. There are three approaches to generate surplus revenue: increased revenue, decreased cost, and reallocation of resources. Extending their earlier work, where they established strategic benchmarks for annual…

Maladaptive Perfectionism, Adult Attachment, and Self-Esteem in College Students

ERIC Educational Resources Information Center

Rice, Kenneth G.; Lopez, Frederick G.

2004-01-01

Extending an earlier study that found high self-esteem to modify the impact of otherwise maladaptive perfectionism on depression, the current study used adult attachment theory to explore the link between perfectionism, self-esteem, and depression in college students. Results indicated that self-esteem buffered the effects of maladaptive…

Motivational Profiles of Veterans Seeking Substance Abuse Treatment: Profiles Based on Stages of Change.

ERIC Educational Resources Information Center

Carney, Margaret M.; Kivlahan, Daniel R.

This study replicated an earlier study which identified five subtypes of outpatient alcoholics (Uninvolved, Participation, Ambivalent, Precontemplation, Contemplation) according to the stages of change model, extending the effort to 404 polydrug users at a Veterans Administration hospital. Subjects were administered a demographic questionnaire;…

Special Education Teachers Integrating Reading with Eighth Grade U.S. History Content

ERIC Educational Resources Information Center

O'Connor, Rollanda E.; Sanchez, Victoria; Beach, Kristen D.; Bocian, Kathleen M.

2017-01-01

This research replicates an earlier study and extends it by shifting instructional responsibility from researchers to special education teachers, who implemented reading instruction that included multisyllabic word decoding, academic vocabulary, and three comprehension strategies (generating main ideas, comparing and contrasting people and events,…

MODELING AIR FLOW DYNAMICS IN RADON MITIGATION SYSTEMS: A SIMPLIFIED APPROACH

EPA Science Inventory

The paper refines and extends an earlier study--relating to the design of optimal radon mitigation systems based on subslab depressurization-- that suggested that subslab air flow induced by a central suction point be treated as radial air flow through a porous bed contained betw...

Credentialism: Partners for Business Education. Working Papers of Planning and Development Research 90-6.

ERIC Educational Resources Information Center

Protz, Maria

This study examined the current value of credentialism, extending the findings of an earlier report, "Business Training: Content, Enrollment and Delivery." The study acknowledged the distinction between various types of credentials, but focused primarily on professional business certification and investigated the potential for TVOntario…

A Multivariate Model of Conceptual Change

ERIC Educational Resources Information Center

Taasoobshirazi, Gita; Heddy, Benjamin; Bailey, MarLynn; Farley, John

2016-01-01

The present study used the Cognitive Reconstruction of Knowledge Model (CRKM) model of conceptual change as a framework for developing and testing how key cognitive, motivational, and emotional variables are linked to conceptual change in physics. This study extends an earlier study developed by Taasoobshirazi and Sinatra ("J Res Sci…

Realizable feed-element patterns and optimum aperture efficiency in multibeam antenna systems

NASA Technical Reports Server (NTRS)

Yngvesson, K. S.; Rahmat-Samii, Y.; Johansson, J. F.; Kim, Y. S.

1988-01-01

The results of an earlier paper by Rahmat-Samii et al. (1981), regarding realizable patterns from feed elements that are part of an array that feeds a reflector antenna, are extended. The earlier paper used a cos exp q theta model for the element radiation pattern, whereas here a parametric study is performed, using a model that assumes a central beam of cos exp q theta shape, with a constant sidelobe level outside the central beam. Realizable q-values are constrained by the maximum directivity based on feed element area. The optimum aperture efficiency (excluding array feed network losses) in an array-reflector system is evaluated as a function of element spacing using this model as well as the model of the earlier paper. Experimental data for tapered slot antenna (TSA) arrays are in agreement with the conclusions based on the model.

Rapid Modeling and Analysis Tools: Evolution, Status, Needs and Directions

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Stone, Thomas J.; Ransom, Jonathan B. (Technical Monitor)

2002-01-01

Advanced aerospace systems are becoming increasingly more complex, and customers are demanding lower cost, higher performance, and high reliability. Increased demands are placed on the design engineers to collaborate and integrate design needs and objectives early in the design process to minimize risks that may occur later in the design development stage. High performance systems require better understanding of system sensitivities much earlier in the design process to meet these goals. The knowledge, skills, intuition, and experience of an individual design engineer will need to be extended significantly for the next generation of aerospace system designs. Then a collaborative effort involving the designer, rapid and reliable analysis tools and virtual experts will result in advanced aerospace systems that are safe, reliable, and efficient. This paper discusses the evolution, status, needs and directions for rapid modeling and analysis tools for structural analysis. First, the evolution of computerized design and analysis tools is briefly described. Next, the status of representative design and analysis tools is described along with a brief statement on their functionality. Then technology advancements to achieve rapid modeling and analysis are identified. Finally, potential future directions including possible prototype configurations are proposed.

Variations in a university subject pool as a function of earlier or later participation and self-report: a replication and extension.

PubMed

Bernard, Larry C; Walsh, R Patricia

2002-10-01

The present study replicated and extended earlier research on temporal sampling effects in university subject pools. Data were obtained from 236 participants, 79 men and 157 women, in a university subject pool during a 15-wk. semester. Without knowing the purpose of the study, participants self-selected to participate earlier (Weeks 4 and 5; n = 105) or later (Weeks 14 and 15; n = 131). Three hypotheses were investigated: (1) that the personality patterns of earlier and later participants on the NEO Personality Inventory-Revised and the Personality Research Form differ significantly, with earlier participants scoring higher on the latter scales reflecting social responsibility and higher on former Conscientiousness and Neuroticism scales; (2) that there are similar significant differences between participants in the earlier and later groups compared to the male and female college normative samples for the two tests: and (3) that earlier participants will have higher actual Scholastic Assessment Test scores and Grade Point Averages. Also investigated was whether participants' foreknowledge that their actual Scholastic Assessment Test scores and Grade Point Averages would be obtained would affect their accuracy of self-report. In contrast to prior research, neither the first nor second hypothesis was supported by the current study; there do not appear to be consistent differences on personality variables. However, the third hypothesis was supported. Earlier participants had higher actual high school Grade Point Average, college Grade Point Average, and Scholastic Assessment Test Verbal scores. Foreknowledge that actual Scholastic Assessment Test scores and Grade Point Averages would be obtained did not affect the accuracy of self-report. In addition, later participants significantly over-reported their scores, and significantly more women than men and more first-year than senior-year subjects participated in the early group.

Analysis of He I 1083 nm Imaging Spectroscopy Using a Spectral Standard

NASA Technical Reports Server (NTRS)

Malanushenko, Elena V.; Jones, Harrison P.

2004-01-01

We develop a technique. for the analysis of He I 1083 nanometer spectra which addresses several difficulties through determination of a continuum background by comparison with a well calibrated standard and through removal of nearby solar and telluric blends by differential comparison to an average spectrum. The method is compared with earlier analysis of imaging spectroscopy obtained at the National Solar Observatory/Kitt Peak Vacuum Telescope (NSO/KPVT) with the NASA/NSO Spectromagnetograph (SPM). We examine distributions of Doppler velocity and line width as a function of central intensity for an active region, filament, quiet Sun, and coronal hole. For our example, we find that line widths and central intensity are oppositely correlated in a coronal hole and quiet Sun. Line widths are comparable to the quiet sun in the active region, are systematically lower in the filament, and extend to higher values in the coronal hole. Outward velocities of approximately equal to 2 to 4 kilometers per second are typically observed in the coronal hole. The sensitivity of these results to analysis technique is discussed.

Turbofan forced mixer lobe flow modeling. 2: Three-dimensional inviscid mixer analysis (FLOMIX)

NASA Technical Reports Server (NTRS)

Barber, T.

1988-01-01

A three-dimensional potential analysis (FLOMIX) was formulated and applied to the inviscid flow over a turbofan foced mixer. The method uses a small disturbance formulation to analytically uncouple the circumferential flow from the radial and axial flow problem, thereby reducing the analysis to the solution of a series of axisymmetric problems. These equations are discretized using a flux volume formulation along a Cartesian grid. The method extends earlier applications of the Cartesian method to complex cambered geometries. The effects of power addition are also included within the potential formulation. Good agreement is obtained with an alternate small disturbance analysis for a high penetration symmetric mixer in a planar duct. In addition, calculations showing pressure distributions and induced secondary vorticity fields are presented for practical trubofan mixer configurations, and where possible, comparison was made with available experimental data. A detailed description of the required data input and coordinate definition is presented along with a sample data set for a practical forced mixer configuration. A brief description of the program structure and subroutines is also provided.

International Patterns of the Public Awareness of Aphasia

ERIC Educational Resources Information Center

Code, Chris; Papathanasiou, Ilias; Rubio-Bruno, Silvia; Cabana, María de la Paz; Villanueva, Maria Marta; Haaland-Johansen, Line; Prizl-Jakovac, Tatjana; Leko, Ana; Zemva, Nada; Patterson, Ruth; Berry, Richard; Rochon, Elizabeth; Leonard, Carol; Robert, Amelie

2016-01-01

Background: It has been suggested that public awareness of aphasia is vital for extending services, research support, social inclusion and targeted raising of awareness. Earlier studies show that knowledge of aphasia varies across a range of variables, but is very low compared with other conditions. Aims: To report a series of surveys of public…

Democracy Is Little "l" Leadership: For Every Day at Any Time

ERIC Educational Resources Information Center

Bogotch, Ira

2011-01-01

This article directs to the Dialogues of Leadership Education section of "Scholar-Practitioner Quarterly," Volume 4, Issue 4, wherein the contributing authors examined the question of priorities of leadership education for a democratic society. In this article, the author extends that earlier dialogue, and draws into specific relief the language…

Optical-to-optical interface device

NASA Technical Reports Server (NTRS)

Jacobson, A. D.; Bleha, W. P.; Miller, L.; Grinberg, J.; Fraas, L.; Margerum, D.

1975-01-01

An investigation was conducted to develop an optical-to-optical interface device capable of performing real-time incoherent-to-incoherent optical image conversion. The photoactivated liquid crystal light valve developed earlier represented a prototype liquid crystal light valve device capable of performing these functions. A device was developed which had high performance and extended lifetime.

The Development of Two Types of Inhibitory Control in Monolingual and Bilingual Children

ERIC Educational Resources Information Center

Martin-Rhee, Michelle M.; Bialystok, Ellen

2008-01-01

Previous research has shown that bilingual children excel in tasks requiring inhibitory control to ignore a misleading perceptual cue. The present series of studies extends this finding by identifying the degree and type of inhibitory control for which bilingual children demonstrate this advantage. Study 1 replicated the earlier research by…

Examining Culturally Structured Learning Environments with Different Types of Music-Linked Movement Opportunity

ERIC Educational Resources Information Center

Cole, Juanita M.; Boykin, A. Wade

2008-01-01

This study describes two experiments that extended earlier work on the Afrocultural theme Movement Expression. The impact of various learning conditions characterized by different types of music-linked movement on story recall performance was examined. African American children were randomly assigned to a learning condition, presented a story, and…

Mining LMS Data to Develop an "Early Warning System" for Educators: A Proof of Concept

ERIC Educational Resources Information Center

Macfadyen, Leah P.; Dawson, Shane

2010-01-01

Earlier studies have suggested that higher education institutions could harness the predictive power of Learning Management System (LMS) data to develop reporting tools that identify at-risk students and allow for more timely pedagogical interventions. This paper confirms and extends this proposition by providing data from an international…

Shame, Guilt, Symptoms of Depression, and Reported History of Psychological Maltreatment

ERIC Educational Resources Information Center

Webb, Marcia; Heisler, Dawn; Call, Steve; Chickering, Sarah A.; Colburn, Trina A.

2007-01-01

Objective: The purpose of the present study was to provide preliminary data extending earlier research on shame and guilt, examining their relationships both to symptoms of depression and to psychological maltreatment. Symptoms of depression were expected to correlate positively with shame, but not with guilt. Psychological maltreatment was also…

British Naval Aviation and the Anti-Submarine Campaign, 1917-18

DTIC Science & Technology

2004-01-01

me. Also, I extend my gratitude to Col Phil Meilinger, USAF (Ret.) and Lt Col Roy Houchin, USAF, for reading some of my earlier chapter drafts and...Revolution, 1912-1918. London: Frank Cass, 1999. Barker, Ralph. A Brief History of the Royal Flying Corps in World War I. London: Robinson, 2002. Beckett

Advanced Internship: A High-Impact, Low-Cost, Super-Capstone Course

ERIC Educational Resources Information Center

Fernald, Peter S.; Goldstein, Gary S.

2013-01-01

In an earlier issue of this journal, the authors described a capstone course, Internship, that both "caps" the undergraduate experience and functions as a "bridge" to the world beyond college. Here, they describe a sequel to that course, Advanced Internship, which both extends and enhances the "capping" and "bridging" experiences. The bridging…

K-shell photoelectric cross sections for intermediate-Z elements at 26 keV

NASA Astrophysics Data System (ADS)

Kumar, Suresh; Singh, N.; Allawadhi, K. L.; Sood, B. S.

1986-08-01

Our earlier measurements of K-shell photoelectric cross sections for intermediate Z elements at 74 and 37 keV have been extended to 26 keV using external conversion x rays in Sn. The experimental results are found to show fairly good agreement with the theoretical values of Scofield.

Rules of the Mind.

ERIC Educational Resources Information Center

Anderson, John R.

Related to the earlier ACT production system theory, this book's basic goal is to present evidence for the psychological reality of a production system model of mind. Distinguished from the original theory in three ways, this volume uses previous rational analyses to improve upon that theory and extend its scope. It also relates the theory to new…

A Narratable Self as Addressed by Human Rights

ERIC Educational Resources Information Center

Adami, Rebecca

2017-01-01

The paper extends the critique in earlier research of human rights as exclusive of otherness and difference by introducing the work of Adriana Cavarero (2000) on a "narratable self." Hence, the formation of human rights is thus about the relations between different narratable selves, not just Western ones. A narrative learning, drawing…

Radiation-Induced Leukemia at Doses Relevant to Radiation Therapy: Modeling Mechanisms and Estimating Risks

NASA Technical Reports Server (NTRS)

Shuryak, Igor; Sachs, Rainer K.; Hlatky, Lynn; Mark P. Little; Hahnfeldt, Philip; Brenner, David J.

2006-01-01

Because many cancer patients are diagnosed earlier and live longer than in the past, second cancers induced by radiation therapy have become a clinically significant issue. An earlier biologically based model that was designed to estimate risks of high-dose radiation induced solid cancers included initiation of stem cells to a premalignant state, inactivation of stem cells at high radiation doses, and proliferation of stem cells during cellular repopulation after inactivation. This earlier model predicted the risks of solid tumors induced by radiation therapy but overestimated the corresponding leukemia risks. Methods: To extend the model to radiation-induced leukemias, we analyzed in addition to cellular initiation, inactivation, and proliferation a repopulation mechanism specific to the hematopoietic system: long-range migration through the blood stream of hematopoietic stem cells (HSCs) from distant locations. Parameters for the model were derived from HSC biologic data in the literature and from leukemia risks among atomic bomb survivors v^ ho were subjected to much lower radiation doses. Results: Proliferating HSCs that migrate from sites distant from the high-dose region include few preleukemic HSCs, thus decreasing the high-dose leukemia risk. The extended model for leukemia provides risk estimates that are consistent with epidemiologic data for leukemia risk associated with radiation therapy over a wide dose range. For example, when applied to an earlier case-control study of 110000 women undergoing radiotherapy for uterine cancer, the model predicted an excess relative risk (ERR) of 1.9 for leukemia among women who received a large inhomogeneous fractionated external beam dose to the bone marrow (mean = 14.9 Gy), consistent with the measured ERR (2.0, 95% confidence interval [CI] = 0.2 to 6.4; from 3.6 cases expected and 11 cases observed). As a corresponding example for brachytherapy, the predicted ERR of 0.80 among women who received an inhomogeneous low-dose-rate dose to the bone marrow (mean = 2.5 Gy) was consistent with the measured ERR (0.62, 95% Cl =-0.2 to 1.9). Conclusions: An extended, biologically based model for leukemia that includes HSC initiation, inactivation, proliferation, and, uniquely for leukemia, long-range HSC migration predicts, %Kith reasonable accuracy, risks for radiationinduced leukemia associated with exposure to therapeutic doses of radiation.

Concentration of stable elements in food products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montford, M.A.; Shank, K.E.; Hendricks, C.

1980-01-01

Food samples were taken from commercial markets and analyzed for stable element content. The concentrations of most stable elements (Ag, Al, As, Au, Ba, Br, Ca, Ce, Cl, Co, Cr, Cs, Cu, Fe, Hf, I, K, La, Mg, Mn, Mo, Na, Rb, Sb, Sc, Se, Sr, Ta, Th, Ti, V, Zn, Zr) were determined using multiple-element neutron activation analysis, while the concentrations of other elements (Cd, Hg, Ni, Pb) were determined using atomic absorption. The relevance of the concentrations found are noted in relation to other literature values. An earlier study was extended to include the determination of the concentrationmore » of stable elements in home-grown products in the vicinity of the Oak Ridge National Laboratory. Comparisons between the commercial and local food-stuff values are discussed.« less

Studies for Io's extended atmosphere and neutral clouds and their impact on the local satellite atmosphere and on the planetary magnetosphere

NASA Technical Reports Server (NTRS)

Smyth, William H.

1993-01-01

The research performed in this project is divided in two main investigations: (1) the synthesis and analysis of a collection of independent observations for Io's sodium corona, its sodium extended atmosphere, and the sodium cloud, and (2) the analysis of a (System III longitude correlated) space-time 'bite-out' near western elongation in the 1981 sodium cloud images from the JPL Table Mountain Sodium Cloud Data Set. For the first investigation, modeling analysis of the collective observed spatial profiles has shown that they are reproduced by adopting at Io's exobase a modified sputtering flux speed distribution function which is peaked near 0.5 km/s and has a small high-speed (15-20 km/s) nonisotropic component. The nonisotropic high-speed component is consistent with earlier modeling of the trailing directional feature. For the second investigation, modeling analysis of the 'bite-out' observed near western elongation (but not eastern elongation) has shown that it is reproduced in model calculation by adopting a plasma torus description for the sodium lifetime that is inherently asymmetric in System III longitudes of the active sector and that also has an east-west asymmetry. The east-west and System III longitude asymmetries were determined from independent observations for the plasma torus in 1981. The presence of the 'bite-out' feature only near western elongation may be understood in terms of the relative value for sodium of its lifetime and its transport time through the System III enhanced plasma torus region.

37 CFR 1.78 - Claiming benefit of earlier filing date and cross-references to other applications.

Code of Federal Regulations, 2012 CFR

2012-07-01

... such prior-filed application, identifying it by application number (consisting of the series code and.... These time periods are not extendable. Except as provided in paragraph (a)(3) of this section, the... application. The time periods in this paragraph do not apply if the later-filed application is: (A) An...

77 FR 45388 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

... Change The Exchange proposes to extend the operation of its Supplemental Liquidity Providers Pilot (``SLP... operation of its SLP Pilot,\\4\\ currently scheduled to expire on July 31, 2012, until the earlier of... No. 58877 (October 29, 2008), 73 FR 65904 (November 5, 2008) (SR-NYSE-2008-108) (establishing the SLP...

Parenting Behavior as Mediator and Moderator of the Association between Marital Problems and Adolescent Maladjustment

ERIC Educational Resources Information Center

Cui, Ming; Conger, Rand D.

2008-01-01

The present study examines the mediating and moderating effects of parenting behavior on the relation between marital problems and adolescent maladjustment. Extending earlier studies by using a prospective, longitudinal research design and multi-informant methods, this study of 451 adolescents and their families from the Iowa Youth and Families…

Improving Performance in Quantum Mechanics with Explicit Incentives to Correct Mistakes

ERIC Educational Resources Information Center

Brown, Benjamin R.; Mason, Andrew; Singh, Chandralekha

2016-01-01

An earlier investigation found that the performance of advanced students in a quantum mechanics course did not automatically improve from midterm to final exam on identical problems even when they were provided the correct solutions and their own graded exams. Here, we describe a study, which extended over four years, in which upper-level…

A School-Based Project in Five Kindergartens: The Case of Teacher Development and School Development

ERIC Educational Resources Information Center

Ling Li, Yuen

2004-01-01

Kindergarten teachers in Hong Kong are blamed for not putting child-initiated learning theory into practice. Their competence is challenged. An earlier study ( Li, 2003 ) suggested that the professional development of kindergarten teachers was limited by their inability to extend thinking beyond their own personal concerns so that the needs of the…

Alberta Education Energy Conservation Project. Phase II: Internal Evaluation.

ERIC Educational Resources Information Center

Sundmark, Dana

This report is based on the Alberta Education Energy Conservation Project - Phase II. The project was a follow-up to an earlier study, extending from June 1980 to June 1983, in which government funding and engineering manpower were used to conduct an energy management program in 52 selected pilot schools in 5 areas of the province. The report…

A range extension for Carex sartwellii in interior Alaska

Treesearch

Mark Winterstein; Teresa N Hollingsworth; Carolyn Parker

2016-01-01

Our documentation of Sartwell’s Sedge, Carex sartwellii, on nine shrinking lakes during fieldwork in the central Yukon Flats, Alaska, represents a range extension for this species. Previously, its range extended as far northwest as Yukon, Canada, with a reported, but lost collection, from Alaska in 1895. Two earlier collections from the Yukon Flats...

The Monitoring the Future Project After Thirty-Two Years: Design and Procedures. Monitoring the Future Occasional Paper 64

ERIC Educational Resources Information Center

Bachman, Jerald G.; Johnston, Lloyd D.; O'Malley, Patrick M.; Schulenberg, John E.

2006-01-01

This occasional paper updates and extends earlier papers in the Monitoring the Future project. It provides a detailed description of the project's design, including sampling design, data collection procedures, measurement content, and questionnaire format. It attempts to include sufficient information for others who wish to evaluate the results,…

Current Perceptions of Marital Rape: Some Good and Not-So-Good News

ERIC Educational Resources Information Center

Ferro, Christine; Cermele, Jill; Saltzman, Ann

2008-01-01

The current study extends previous research on marital rape and acceptance of general rape myths by comparing the perceptions of undergraduate college students (n = 85) to those of college alumni/ae (n = 44) who graduated from the same university three decades earlier. Participants read a hypothetical rape scenario that depicted the perpetrator as…

75 FR 10543 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... suspend certain rule requirements at the close when extreme order imbalances may cause significant... Imbalances Pilot'' or ``Pilot'').\\4\\ Through this filing, NYSE proposes to extend the Pilot until the earlier... suspend NYSE Rules 52 (Hours of Operation) to resolve an extreme order imbalance that may result in a...

A Reevaluation of Age-Related Changes in Associative Memory Organization.

ERIC Educational Resources Information Center

Lindauer, Barbara K.; Paris, Scott G.

This paper focuses on a study which replicates and extends earlier work employing a recognition memory paradigm to investigate children's memory and developmental changes in dominant word associations. On the recognition test the implicit associative response can lead to better memory for the original items (this is the hit rate), and it can also…

Multi-Institution Study of Student Demographics and Outcomes in Electrical and Computer Engineering in the USA

ERIC Educational Resources Information Center

Lord, Susan M.; Layton, Richard A.; Ohland, Matthew W.

2015-01-01

Electrical Engineering (EE) and Computer Engineering (CpE) programs have similar curricula, but different demographics and student outcomes. This paper extends earlier longitudinal studies to a larger and more diverse dataset with 90,000 first-time-in-college and 26,000 transfer students who majored in engineering at USA institutions, including…

Online Counselling: Learning from Writing Therapy.

ERIC Educational Resources Information Center

Wright, Jeannie

2002-01-01

This article aims to extend an earlier review of some of the research into writing therapy and to indicate how it could be applied to online counseling. It also refers to some of the literature on online counseling, which, together with the writing therapy research, informed the decision to offer an online service to staff in a university setting.…

The Services Performed By American Colleges and Universities for Agriculture and Industry.

ERIC Educational Resources Information Center

Cowley, W. H.; Jacks, David

During the ninety-eight years since Abraham Lincoln signed the Land Grant College Act, American colleges and universities have prodigiously expanded and extended the activities begun even earlier by alert pioneers. No longer do they limit themselves to the polite learning of interest to the republic of letters. Their services for agriculture and…

Extended duration orbiter medical project countermeasure to reduce post space flight orthostatic intolerance (LBNP) (STS-50/USML-1)

NASA Technical Reports Server (NTRS)

Charles, John B.; Boettcher, Sheila W.

1994-01-01

During the STS-50/USML-1 mission and five other Shuttle flights, decompression of the legs and lower abdomen ('lower body negative pressure,' LBNP) was used: (1) to apply a standardized stress to the cardiovascular system, to document the loss of orthostatic function during an extended period in weightlessness, and (2) to test its efficacy as a treatment which may be used to protect astronauts from gravitationally-induced fainting during and after reentry on Space Shuttle flights. The loss of orthostatic tolerance (as determined by LBNP) occured even earlier than indicated by similar testing on Skylab (1973-1974). The treatment was shown to be effective in reversing some of the effects of extended weightlessness on the cardiovascular system for at least one day after treatment.

Studies of Flame Structure in Microgravity

NASA Technical Reports Server (NTRS)

Law, C. K.; Sung, C. J.; Zhu, D. L.

1997-01-01

The present research endeavor is concerned with gaining fundamental understanding of the configuration, structure, and dynamics of laminar premixed and diffusion flames under conditions of negligible effects of gravity. Of particular interest is the potential to establish and hence study the properties of spherically- and cylindrically-symmetric flames and their response to external forces not related to gravity. For example, in an earlier experimental study of the burner-stabilized cylindrical premixed flames, the possibility of flame stabilization through flow divergence was established, while the resulting one-dimensional, adiabatic, stretchless flame also allowed an accurate means of determining the laminar flame speeds of combustible mixtures. We have recently extended our studies of the flame structure in microgravity along the following directions: (1) Analysis of the dynamics of spherical premixed flames; (2) Analysis of the spreading of cylindrical diffusion flames; (3) Experimental observation of an interesting dual luminous zone structure of a steady-state, microbuoyancy, spherical diffusion flame of air burning in a hydrogen/methane mixture environment, and its subsequent quantification through computational simulation with detailed chemistry and transport; (4) Experimental quantification of the unsteady growth of a spherical diffusion flame; and (5) Computational simulation of stretched, diffusionally-imbalanced premixed flames near and beyond the conventional limits of flammability, and the substantiation of the concept of extended limits of flammability. Motivation and results of these investigations are individually discussed.

SuperDCA for genome-wide epistasis analysis.

PubMed

Puranen, Santeri; Pesonen, Maiju; Pensar, Johan; Xu, Ying Ying; Lees, John A; Bentley, Stephen D; Croucher, Nicholas J; Corander, Jukka

2018-05-29

The potential for genome-wide modelling of epistasis has recently surfaced given the possibility of sequencing densely sampled populations and the emerging families of statistical interaction models. Direct coupling analysis (DCA) has previously been shown to yield valuable predictions for single protein structures, and has recently been extended to genome-wide analysis of bacteria, identifying novel interactions in the co-evolution between resistance, virulence and core genome elements. However, earlier computational DCA methods have not been scalable to enable model fitting simultaneously to 10 4 -10 5 polymorphisms, representing the amount of core genomic variation observed in analyses of many bacterial species. Here, we introduce a novel inference method (SuperDCA) that employs a new scoring principle, efficient parallelization, optimization and filtering on phylogenetic information to achieve scalability for up to 10 5 polymorphisms. Using two large population samples of Streptococcus pneumoniae, we demonstrate the ability of SuperDCA to make additional significant biological findings about this major human pathogen. We also show that our method can uncover signals of selection that are not detectable by genome-wide association analysis, even though our analysis does not require phenotypic measurements. SuperDCA, thus, holds considerable potential in building understanding about numerous organisms at a systems biological level.

Final safety analysis report for the Galileo Mission: Volume 2: Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The General Purpose Heat Source Radioisotope Thermoelectric Generator (GPHS-RTG) will be used as the prime source of electric power for the spacecraft on the Galileo mission. The use of radioactive material in these missions necessitates evaluations of the radiological risks that may be encountered by launch complex personnel and by the Earth's general population resulting from postulated malfunctions or failures occurring in the mission operations. The purpose of the Final Safety Analysis Report (FSAR) is to present the analyses and results of the latest evaluation of the nuclear safety potential of the GPHS-RTG as employed in the Galileo mission. Thismore » evaluation is an extension of earlier work that addressed the planned 1986 launch using the Space Shuttle Vehicle with the Centaur as the upper stage. This extended evaluation represents the launch by the Space Shuttle/IUS vehicle. The IUS stage has been selected as the vehicle to be used to boost the Galileo spacecraft into the Earth escape trajectory after the parking orbit is attained.« less

The oldest known snakes from the Middle Jurassic-Lower Cretaceous provide insights on snake evolution.

PubMed

Caldwell, Michael W; Nydam, Randall L; Palci, Alessandro; Apesteguía, Sebastián

2015-01-27

The previous oldest known fossil snakes date from ~100 million year old sediments (Upper Cretaceous) and are both morphologically and phylogenetically diverse, indicating that snakes underwent a much earlier origin and adaptive radiation. We report here on snake fossils that extend the record backwards in time by an additional ~70 million years (Middle Jurassic-Lower Cretaceous). These ancient snakes share features with fossil and modern snakes (for example, recurved teeth with labial and lingual carinae, long toothed suborbital ramus of maxillae) and with lizards (for example, pronounced subdental shelf/gutter). The paleobiogeography of these early snakes is diverse and complex, suggesting that snakes had undergone habitat differentiation and geographic radiation by the mid-Jurassic. Phylogenetic analysis of squamates recovers these early snakes in a basal polytomy with other fossil and modern snakes, where Najash rionegrina is sister to this clade. Ingroup analysis finds them in a basal position to all other snakes including Najash.

Class start times, sleep, and academic performance in college: a path analysis.

PubMed

Onyper, Serge V; Thacher, Pamela V; Gilbert, Jack W; Gradess, Samuel G

2012-04-01

Path analysis was used to examine the relationship between class start times, sleep, circadian preference, and academic performance in college-aged adults. Consistent with observations in middle and high school students, college students with later class start times slept longer, experienced less daytime sleepiness, and were less likely to miss class. Chronotype was an important moderator of sleep schedules and daytime functioning; those with morning preference went to bed and woke up earlier and functioned better throughout the day. The benefits of taking later classes did not extend to academic performance, however; grades were somewhat lower in students with predominantly late class schedules. Furthermore, students taking later classes were at greater risk for increased alcohol consumption, and among all the factors affecting academic performance, alcohol misuse exerted the strongest effect. Thus, these results indicate that later class start times in college, while allowing for more sleep, also increase the likelihood of alcohol misuse, ultimately impeding academic success.

Shapes of Nonbuoyant Round Luminous Laminar-Jet Diffusion Flames in Coflowing Air. Appendix F

NASA Technical Reports Server (NTRS)

Lin, K.-C.; Faeth, G. M.; Urban, David L. (Technical Monitor)

2000-01-01

The shapes (luminous flame boundaries) of steady nonbuoyant round luminous hydrocarbon-fueled laminar-jet diffusion flames in coflowing air were studied both experimentally and theoretically. Flame shapes were measured from photographs of flames burning at low pressures in order to minimize the effects of buoyancy. Test conditions involved acetylene-, propylene. and 1,3-butadiene-fueled flames having initial reactant temperatures of 300 K, ambient pressures of 19-50 kPa, jet-exit Reynolds numbers of 18-121, and initial air/fuel velocity ratios of 0.22-32.45 to yield luminous flame lengths of 21-198 mm. The present flames were close to the laminar smoke point but were not soot emitting. Simple expressions to estimate the shapes of nonbuoyant laminar-jet diffusion flames in coflow were found by extending an earlier analysis of Mahalingam et al. These formulas provided a good correlation of present measurements except near the burner exit where self-similar approximations used in the simplified analysis are no longer appropriate.

Radial and latitudinal gradients in the solar internal angular velocity

NASA Technical Reports Server (NTRS)

Rhodes, Edward J., Jr.; Cacciani, Alessandro; Korzennik, Sylvain G.; Tomczyk, Steven; Ulrich, Roger K.; Woodard, Martin F.

1988-01-01

The frequency splittings of intermediate-degree (3 to 170 deg) p-mode oscillations obtained from a 16-day subset of observations were analyzed. Results show evidence for both radial and latitudinal gradients in the solar internal angular velocity. From 0.6 to 0.95 solar radii, the solar internal angular velocity increases systematically from 440 to 463 nHz, corresponding to a positive radial gradient of 66 nHz/solar radius for that portion of the solar interior. Analysis also indicates that the latitudinal differential rotation gradient which is seen at the solar surface persists throughout the convection zone, although there are indications that the differential rotation might disappear entirely below the base of the convection zone. The analysis was extended to include comparisons with additional observational studies and between earlier results and the results of additional inversions of several of the observational datasets. All the comparisons reinforce conclusions regarding the existence of radial and latitudinal gradients in the internal angular velocity.

Genetic diversity of the captive Asian tapir population in Thailand, based on mitochondrial control region sequence data and the comparison of its nucleotide structure with Brazilian tapir.

PubMed

Muangkram, Yuttamol; Amano, Akira; Wajjwalku, Worawidh; Pinyopummintr, Tanu; Thongtip, Nikorn; Kaolim, Nongnid; Sukmak, Manakorn; Kamolnorranath, Sumate; Siriaroonrat, Boripat; Tipkantha, Wanlaya; Maikaew, Umaporn; Thomas, Warisara; Polsrila, Kanda; Dongsaard, Kwanreaun; Sanannu, Saowaphang; Wattananorrasate, Anuwat

2017-07-01

The Asian tapir (Tapirus indicus) has been classified as Endangered on the IUCN Red List of Threatened Species (2008). Genetic diversity data provide important information for the management of captive breeding and conservation of this species. We analyzed mitochondrial control region (CR) sequences from 37 captive Asian tapirs in Thailand. Multiple alignments of the full-length CR sequences sized 1268 bp comprised three domains as described in other mammal species. Analysis of 16 parsimony-informative variable sites revealed 11 haplotypes. Furthermore, the phylogenetic analysis using median-joining network clearly showed three clades correlated with our earlier cytochrome b gene study in this endangered species. The repetitive motif is located between first and second conserved sequence blocks, similar to the Brazilian tapir. The highest polymorphic site was located in the extended termination associated sequences domain. The results could be applied for future genetic management based in captivity and wild that shows stable populations.

Melt segregation from partially molten source regions - The importance of melt density and source region size

NASA Technical Reports Server (NTRS)

Stolper, E.; Hager, B. H.; Walker, D.; Hays, J. F.

1981-01-01

An investigation is conducted regarding the changes expected in the density contrast between basic melts and peridotites with increasing pressure using the limited data available on the compressibilities of silicate melts and data on the densities of mantle minerals. It is concluded that since compressibilities of silicate melts are about an order of magnitude greater than those of mantle minerals, the density contrast between basic melts and mantle minerals must diminish significantly with increasing pressure. An earlier analysis regarding the migration of liquid in partially molten source regions conducted by Walker et al. (1978) is extended, giving particular attention to the influence of the diminished density contrast between melt and residual crystals with increasing source region depth and to the influence of source region size. This analysis leads to several generalizations concerning the factors influencing the depths at which magmas will segregate from their source regions and the degrees of partial melting that can be achieved in these source regions before melt segregation occurs.

Correlation of the rates of solvolysis of α-bromoisobutyrophenone using both simple and extended forms of the Grunwald-Winstein equation and the application of correlation analysis to related studies.

PubMed

Kevill, Dennis Neil; Kim, Chang-Bae; D'Souza, Malcolm John

2018-03-01

A Grunwald-Winstein treatment of the specific rates of solvolysis of α-bromoisobutyrophenone in 100% methanol and in several aqueous ethanol, methanol, acetone, 2,2,2-trifluoroethanol (TFE), and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) mixtures gives a good logarithmic correlation against a linear combination of N T (solvent nucleophilicity) and Y Br (solvent ionizing power) values. The l and m sensitivity values are compared to those previously reported for α-bromoacetophenone and to those obtained from parallel treatments of literature specific rate values for the solvolyses of several tertiary mesylates containing a C(=O)R group attached at the α-carbon. Kinetic data obtained earlier by Pasto and Sevenair for the solvolyses of the same substrate in 75% aqueous ethanol (by weight) in the presence of silver perchlorate and perchloric acid are analyzed using multiple regression analysis.

Use of MODIS Snow-Cover Maps for Detecting Snowmelt Trends in North America

NASA Technical Reports Server (NTRS)

Hall, Dorothy K.; Foster, James L.; Riggs, George A.; Robinson, David A.; Hoon-Starr, Jody A.

2012-01-01

Research has shown that the snow season in the Northern Hemisphere has been getting shorter in recent decades, consistent with documented global temperature increases. Specifically, the snow is melting earlier in the spring allowing for a longer growing season and associated land-cover changes. Here we focus on North America. Using the Moderate-Resolution Imaging Radiometer (MODIS) cloud-gap-filled standard snow-cover data product we can detect a trend toward earlier spring snowmelt in the approx 12 years since the MODIS launch. However, not all areas in North America show earlier spring snowmelt over the study period. We show examples of springtime snowmelt over North America, beginning in March 2000 and extending through the winter of 2012 for all of North America, and for various specific areas such as the Wind River Range in Wyoming and in the Catskill Mountains in New York. We also compare our approx 12-year trends with trends derived from the Rutgers Global Snow Lab snow cover climate-data record.

Operational Implementation of a Pc Uncertainty Construct for Conjunction Assessment Risk Analysis

NASA Technical Reports Server (NTRS)

Newman, Lauri K.; Hejduk, Matthew D.; Johnson, Lauren C.

2016-01-01

Earlier this year the NASA Conjunction Assessment and Risk Analysis (CARA) project presented the theoretical and algorithmic aspects of a method to include the uncertainties in the calculation inputs when computing the probability of collision (Pc) between two space objects, principally uncertainties in the covariances and the hard-body radius. The output of this calculation approach is to produce rather than a single Pc value an entire probability density function that will represent the range of possible Pc values given the uncertainties in the inputs and bring CA risk analysis methodologies more in line with modern risk management theory. The present study provides results from the exercise of this method against an extended dataset of satellite conjunctions in order to determine the effect of its use on the evaluation of conjunction assessment (CA) event risk posture. The effects are found to be considerable: a good number of events are downgraded from or upgraded to a serious risk designation on the basis of consideration of the Pc uncertainty. The findings counsel the integration of the developed methods into NASA CA operations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adare, A.

PHENIX measurements are presented for the cross section and double-helicity asymmetry (ALL) in inclusive π⁰ production at midrapidity from p+p collisions at √s = 510 GeV from data taken in 2012 and 2013 at the Relativistic Heavy Ion Collider. The next-to-leading-order perturbativequantum- chromodynamics theory calculation is in excellent agreement with the presented cross section results. The calculation utilized parton-to-pion fragmentation functions from the recent DSS14 global analysis, which prefer a smaller gluon-to-pion fragmentation function. The π⁰A LL results follow an increasingly positive asymmetry trend with pT and √s with respect to the predictions and are in excellent agreement with themore » latest global analysis results. This analysis incorporated earlier results on π0 and jet A LL, and suggested a positive contribution of gluon polarization to the spin of the proton ΔG for the gluon momentum fraction range x > 0.05. The data presented here extend to a currently unexplored region, down to x 0.01, and thus provide additional constraints on the value of ΔG.« less

On measuring cell confluence in phase contrast microscopy

NASA Astrophysics Data System (ADS)

Dempsey, K. P.; Richardson, J. B.; Lam, K. P.

2014-03-01

A principal focus highlighting recent advances in cell based therapies concerns the development of effective treatments for osteoarthritis. Earlier clinicaltrials have shown that 80% of patients receiving mesenchymal stem cell(MSC) based treatment have improved their quality of life by alleviating pain whilst extending the life of their natural joints. The current challenge facing researchers is to identify the biological differences between the treatments that have worked and those which have shown little improvement. One possible candidate for the difference in treatment prognosis is an examination of the proliferation of the ( type) cells as they grow. To further understanding of the proliferation and differentiation of MSC, non-invasive live cell imaging techniques have been developed which capture important cell events and dynamics in cell divisions over an extended period of time. An automated image analysis procedure capable of tracking cell confluence over time has also been implemented, providing an objective and realistic estimation of cell growth within continuous live cell cultures. The proposed algorithm accounts for the halo artefacts that occur in phase microscopy. In addition to a favourable run-time performance, the method was also validated using continuous live MSC cultures, with consistent and meaningful results.

Nonlinear multivariable design by total synthesis. [of gas turbine engine control systems

NASA Technical Reports Server (NTRS)

Sain, M. K.; Peczkowski, J. L.

1982-01-01

The Nominal Design Problem (NDP) is extended to nonlinear cases, and a new case study of robust feedback synthesis for gas turbine control design is presented. The discussion of NDP extends and builds on earlier Total Synthesis Problem theory and ideas. Some mathematical preliminaries are given in which a bijection from a set S onto a set T is considered, with T admitting the structure of an F-vector space. NDP is then discussed for a nonlinear plant, and nonlinear nominal design is defined and characterized. The design of local controllers for a turbojet and the scheduling of these controls into a global control are addressed.

Contact mechanics for coated spheres that includes the transition from weak to strong adhesion

DOE PAGES

Reedy, Earl David

2007-09-01

Recently published results for a rigid spherical indenter contacting a thin, linear elastic coating on a rigid planar substrate have been extended to include the case of two contacting spheres, where each sphere is rigid and coated with a thin, linear elastic material. This is done by using an appropriately chosen effective radius and coating modulus. Finally, the earlier work has also been extended to provide analytical results that span the transition between the previously derived Derjaguin–Müller–Toporov (DMT)-like (work of adhesion/coating-modulus ratio is small) and Johnson–Kendall–Roberts (JKR)-like (work of adhesion/coating-modulus ratio is large) limits.

Roads to Recovery: Three Skill and Labour Market Scenarios for 2025. Briefing Note

ERIC Educational Resources Information Center

Cedefop - European Centre for the Development of Vocational Training, 2013

2013-01-01

In line with earlier forecasts, Cedefop's projections for skill supply and demand in the European Union (EU) foresee a gradual return to job growth and an older, but better qualified workforce. The latest forecast, which is presented in this report, extends the time horizon from 2020 to 2025 and differs from its predecessors in seeing demand for…

The Creative Use of Companion Values in Environmental Education and Education for Sustainable Development: Exploring the Educative Moment

ERIC Educational Resources Information Center

Garrison, Jim; Östman, Leif; Håkansson, Michael

2015-01-01

Our paper addresses the emergence and evolution of values in educational settings. It builds upon and extends earlier work on companion meanings to develop a theory of the creative use of companion values and meanings in education. The recognition of companion values in educational practices highlight epistemological, ethical, and aesthetic…

A Further Study of Productive Failure in Mathematical Problem Solving: Unpacking the Design Components

ERIC Educational Resources Information Center

Kapur, Manu

2011-01-01

This paper replicates and extends my earlier work on productive failure in mathematical problem solving (Kapur, doi:10.1007/s11251-009-9093-x, 2009). One hundred and nine, seventh-grade mathematics students taught by the same teacher from a Singapore school experienced one of three learning designs: (a) traditional lecture and practice (LP), (b)…

Parent-Child Relationship, Temperament, and Physiological Reactions to Fear-Inducing Film Clips: Further Evidence for Differential Susceptibility

ERIC Educational Resources Information Center

Gilissen, Renske; Bakermans-Kranenburg, Marian J.; van IJzendoorn, Marinus H.; van der Veer, Rene

2008-01-01

Recent studies have supported the intriguing hypothesis that highly reactive infants are most susceptible to the effect of parenting. This study replicates and extends an earlier study on 4-year-olds concerning higher susceptibility of more fearful children to the quality of their relationships with their mothers, as shown by their physiological…

The Association of Quality of Social Relations, Symptom Severity and Intelligence with Anxiety in Children with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Eussen, Mart L. J. M.; Van Gool, Arthur R.; Verheij, Fop; De Nijs, Pieter F. A.; Verhulst, Frank C.; Greaves-Lord, Kirstin

2013-01-01

Limited quality of social relations, milder symptom severity and higher intelligence were shown to account for higher anxiety levels in autism spectrum disorders. The current study replicated and extended earlier findings by combining these three determinants of anxiety in autism spectrum disorders in one study. The sample consisted of 134…

Competitive Argumentation in Computational Theories of Cognition.

DTIC Science & Technology

1982-12-01

elements of number competence are present much earlier than strict Piagetian theory would predict (Gelman & Gallistel , 1978). A successful style of...caused considerable attention to be focused on counting. Observations by Gelman and Gallistell (1978), and others. provided evidence that significant...certain principles of counting. These premises formalized and extended a particular decomposition of counting competence proposed by Gelman and Gallistel

Anyons in an electromagnetic field and the Bargmann-Michel-Telegdi equation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ghosh, S.

1995-05-15

The Lagrangian model for anyons, presented earlier, is extended to include interactions with an external, homogeneous electromagnetic field. Explicit electric and magnetic moment terms for the anyon are introduced in the Lagrangian. The (2+1)-dimensional Bargmann-Michel-Telegdi equation as well as the correct value (2) of the gyromagnetic ratio is rederived, in the Hamiltonian framework.

Differences in the Quality of Maternal Verbalizations and Quantity of Involvement during Hawaiian Mother-Child Interactions.

ERIC Educational Resources Information Center

Dick-Barnes, Margaret; Roberts, Richard N.

Extending earlier findings of the effects of socioeconomic status (SES) on child outcomes, this study investigated the variables of mothers' language complexity (levels of distancing) and degree of involvement in interactions with their children in order to clarify the relationship of the variables to each other and their relationship to their 4-…

Nonsmooth Finite-Time Synchronization of Switched Coupled Neural Networks.

PubMed

Liu, Xiaoyang; Cao, Jinde; Yu, Wenwu; Song, Qiang

2016-10-01

This paper is concerned with the finite-time synchronization (FTS) issue of switched coupled neural networks with discontinuous or continuous activations. Based on the framework of nonsmooth analysis, some discontinuous or continuous controllers are designed to force the coupled networks to synchronize to an isolated neural network. Some sufficient conditions are derived to ensure the FTS by utilizing the well-known finite-time stability theorem for nonlinear systems. Compared with the previous literatures, such synchronization objective will be realized when the activations and the controllers are both discontinuous. The obtained results in this paper include and extend the earlier works on the synchronization issue of coupled networks with Lipschitz continuous conditions. Moreover, an upper bound of the settling time for synchronization is estimated. Finally, numerical simulations are given to demonstrate the effectiveness of the theoretical results.

simulation of the DNA force-extension curve

NASA Astrophysics Data System (ADS)

Shinaberry, Gregory; Mikhaylov, Ivan; Balaeff, Alexander

A molecular dynamics simulation study of the force-extension curve of double-stranded DNA is presented. Extended simulations of the DNA at multiple points along the force-extension curve are conducted with DNA end-to-end length constrained at each point. The calculated force-extension curve qualitatively reproduces the experimental one. The DNA conformational ensemble at each extension shows that the famous plateau of the force-extension curve results from B-DNA melting, whereas the formation of the earlier-predicted novel DNA conformation called 'zip-DNA' takes place at extensions past the plateau. An extensive analysis of the DNA conformational ensemble in terms of base configuration, backbone configuration, solvent interaction energy, etc., is conducted in order to elucidate the physical origin of DNA elasticity and the main interactions responsible for the shape of the force-extension curve.

Lagrangian methods in the analysis of nonlinear wave interactions in plasma

NASA Technical Reports Server (NTRS)

Galloway, J. J.

1972-01-01

An averaged-Lagrangian method is developed for obtaining the equations which describe the nonlinear interactions of the wave (oscillatory) and background (nonoscillatory) components which comprise a continuous medium. The method applies to monochromatic waves in any continuous medium that can be described by a Lagrangian density, but is demonstrated in the context of plasma physics. The theory is presented in a more general and unified form by way of a new averaged-Lagrangian formalism which simplifies the perturbation ordering procedure. Earlier theory is extended to deal with a medium distributed in velocity space and to account for the interaction of the background with the waves. The analytic steps are systematized, so as to maximize calculational efficiency. An assessment of the applicability and limitations of the method shows that it has some definite advantages over other approaches in efficiency and versatility.

Towards high-performance materials for road construction

NASA Astrophysics Data System (ADS)

Gladkikh, V.; Korolev, E.; Smirnov, V.

2017-10-01

Due to constant increase of traffic, modern road construction is in need of high-performance pavement materials. The operational performance of such materials can be characterized by many properties. Nevertheless, the most important ones are resistance to rutting and resistance to dynamical loads. It was proposed earlier to use sulfur extended asphalt concrete in road construction practice. To reduce the emission of sulfur dioxide and hydrogen sulfide during the concrete mix preparation and pavement production stages, it is beneficial to make such a concrete on the base of complex sulfur modifier. In the present work the influence of the complex modifier to mechanical properties of sulfur extended asphalt concrete was examined. It was shown that sulfur extended asphalt concrete is of high mechanical properties. It was also revealed that there as an anomalous negative correlations between strain capacity, fatigue life and fracture toughness.

A methodology for extending domain coverage in SemRep.

PubMed

Rosemblat, Graciela; Shin, Dongwook; Kilicoglu, Halil; Sneiderman, Charles; Rindflesch, Thomas C

2013-12-01

We describe a domain-independent methodology to extend SemRep coverage beyond the biomedical domain. SemRep, a natural language processing application originally designed for biomedical texts, uses the knowledge sources provided by the Unified Medical Language System (UMLS©). Ontological and terminological extensions to the system are needed in order to support other areas of knowledge. We extended SemRep's application by developing a semantic representation of a previously unsupported domain. This was achieved by adapting well-known ontology engineering phases and integrating them with the UMLS knowledge sources on which SemRep crucially depends. While the process to extend SemRep coverage has been successfully applied in earlier projects, this paper presents in detail the step-wise approach we followed and the mechanisms implemented. A case study in the field of medical informatics illustrates how the ontology engineering phases have been adapted for optimal integration with the UMLS. We provide qualitative and quantitative results, which indicate the validity and usefulness of our methodology. Published by Elsevier Inc.

Comparative Study of foF2 Measurements with IRI-2007 Model Predictions During Extended Solar Minimum

NASA Technical Reports Server (NTRS)

Zakharenkova, I. E.; Krankowski, A.; Bilitza, D.; Cherniak, Iu.V.; Shagimuratov, I.I.; Sieradzki, R.

2013-01-01

The unusually deep and extended solar minimum of cycle 2324 made it very difficult to predict the solar indices 1 or 2 years into the future. Most of the predictions were proven wrong by the actual observed indices. IRI gets its solar, magnetic, and ionospheric indices from an indices file that is updated twice a year. In recent years, due to the unusual solar minimum, predictions had to be corrected downward with every new indices update. In this paper we analyse how much the uncertainties in the predictability of solar activity indices affect the IRI outcome and how the IRI values calculated with predicted and observed indices compared to the actual measurements.Monthly median values of F2 layer critical frequency (foF2) derived from the ionosonde measurements at the mid-latitude ionospheric station Juliusruh were compared with the International Reference Ionosphere (IRI-2007) model predictions. The analysis found that IRIprovides reliable results that compare well with actual measurements, when the definite (observed and adjusted) indices of solar activityare used, while IRI values based on earlier predictions of these indices noticeably overestimated the measurements during the solar minimum.One of the principal objectives of this paper is to direct attention of IRI users to update their solar activity indices files regularly.Use of an older index file can lead to serious IRI overestimations of F-region electron density during the recent extended solar minimum.

A SAMPLE OF SEYFERT-2 GALAXIES WITH ULTRALUMINOUS GALAXY-WIDE NARROW-LINE REGIONS: QUASAR LIGHT ECHOES?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schirmer, M.; Diaz, R.; Levenson, N. A.

2013-01-20

We report the discovery of Seyfert-2 galaxies in SDSS-DR8 with galaxy-wide, ultraluminous narrow-line regions (NLRs) at redshifts z = 0.2-0.6. With a space density of 4.4 Gpc{sup -3} at z {approx} 0.3, these 'green beans' (GBs) are amongst the rarest objects in the universe. We are witnessing an exceptional and/or short-lived phenomenon in the life cycle of active galactic nuclei (AGNs). The main focus of this paper is on a detailed analysis of the GB prototype galaxy J2240-0927 (z = 0.326). Its NLR extends over 26 Multiplication-Sign 44 kpc and is surrounded by an extended NLR. With a total [Omore » III] {lambda}5008 luminosity of (5.7 {+-} 0.9) Multiplication-Sign 10{sup 43} erg s{sup -1}, this is one of the most luminous NLRs known around any type-2 galaxy. Using VLT/XSHOOTER, we show that the NLR is powered by an AGN, and we derive resolved extinction, density, and ionization maps. Gas kinematics is disturbed on a global scale, and high-velocity outflows are absent or faint. This NLR is unlike any other NLR or extended emission line region known. Spectroscopy with Gemini/GMOS reveals extended, high-luminosity [O III] emission also in other GBs. WISE 24 {mu}m luminosities are 5-50 times lower than predicted by the [O III] fluxes, suggesting that the NLRs reflect earlier, very active quasar states that have strongly subsided in less than a galaxy's light-crossing time. These light echoes, or ionization echoes, are about 100 times more luminous than any other such echo known to date. X-ray data are needed for photoionization modeling and to verify the light echoes.« less

The NaK 1 1,3delta states: theoretical and experimental studies of fine and hyperfine structure of rovibrational levels near the dissociation limit.

PubMed

Wilkins, A D; Morgus, L; Hernandez-Guzman, J; Huennekens, J; Hickman, A P

2005-09-22

Earlier high-resolution spectroscopic studies of the fine and hyperfine structure of rovibrational levels of the 1 3delta state of NaK have been extended to include high lying rovibrational levels with v < or = 59, of which the highest levels lie within approximately 4 cm(-1) of the dissociation limit. A potential curve is determined using the inverted perturbation approximation method that reproduces these levels to an accuracy of approximately 0.026 cm(-1). For the largest values of v, the outer turning points occur near R approximately 12.7 angstroms, which is sufficiently large to permit the estimation of the C6 coefficient for this state. The fine and hyperfine structure of the 1 3delta rovibrational levels has been fit using the matrix diagonalization method that has been applied to other states of NaK, leading to values of the spin-orbit coupling constant A(v) and the Fermi contact constant b(F). New values determined for v < or = 33 are consistent with values determined by a simpler method and reported earlier. The measured fine and hyperfine structure for v in the range 44 < or = v < or = 49 exhibits anomalous behavior whose origin is believed to be the mixing between the 1 3delta and 1 1delta states. The matrix diagonalization method has been extended to treat this interaction, and the results provide an accurate representation of the complicated patterns that arise. The analysis leads to accurate values for A(v) and b(F) for all values of v < or = 49. For higher v (50 < or = v < or = 59), several rovibrational levels have been assigned, but the pattern of fine and hyperfine structure is difficult to interpret. Some of the observed features may arise from effects not included in the current model.

The Beck Depression Inventory: Testing for Invariant Measurement and Structure across Gender for Nonclinical Adolescents.

ERIC Educational Resources Information Center

Byrne, Barbara M.; And Others

Extending the earlier work of B. M. Byrne and P. Baron (1990), the factorial invariance of the 21-item Beck Depression Inventory (BDI) was tested using 351 non-clinical adolescent males and 334 non-clinical adolescent females. All subjects were in grades 9 through 12 and attended the same secondary school in a large metropolitan area in central…

The Awareness of Risky Peer Group Behaviors on School Grounds as Predictors of Students' Victimization on School Grounds: Part II--Junior High Schools.

ERIC Educational Resources Information Center

Astor, Ron Avi; Benbenishty, Rami; Haj-Yahia, Muhammad M.; Zeira, Anat; Perkins-Hart, Suzanne; Marachi, Roxana; Pitner, Ronald O.

2002-01-01

Examined how risky peer group behaviors at school impacted junior high students' experience of victimization, extending findings from an earlier study of elementary students. Surveys of Arab and Jewish Israeli junior high students indicated that risky peer behaviors in school were one of the strongest predictors of victimization in both elementary…

To Gain, Retain and Retrain: The Role of Post-School Education for People with a Disability. Research Report

ERIC Educational Resources Information Center

Polidano, Cain; Vu, Ha

2011-01-01

This study extends previous work of Cain Polidano and Kostas Mavromaras (2010) which showed that vocational education and training (VET) qualifications had a positive effect on the chances of finding work for people with a disability. It teases out this earlier result by looking at whether, for those who already have a disability, completing a VET…

Common Core Standards for Middle School English Language Arts: A Quick-Start Guide

ERIC Educational Resources Information Center

Kendall, John; Frazee, Dana J.; Ryan, Susan

2012-01-01

Go in depth on Common Core Standards for middle schools to learn how they help students build on and extend skills acquired in earlier grades and prepare them for the nuanced communication and analytical work they will encounter in high school. Getting a copy for every teacher ensures they'll know: (1) The key focus areas of the Common Core…

A National Information Network: Changing Our Lives in the 21st Century. 1992 Annual Review of the Institute for Information Studies.

ERIC Educational Resources Information Center

Aspen Inst., Queenstown, MD.

In a workshop held by the National Research Council through their Board on Telecommunications and Computer Applications, the participants determined that the earlier vision of affordable telephone service for all, already fundamentally achieved in the United States, can be extended to a new national policy of affordable information for all. This…

Grothendieck-Verdier duality patterns in quantum algebra

NASA Astrophysics Data System (ADS)

Manin, Yu I.

2017-08-01

After a brief survey of the basic definitions of Grothendieck-Verdier categories and dualities, I consider in this context dualities introduced earlier in the categories of quadratic algebras and operads, largely motivated by the theory of quantum groups. Finally, I argue that Dubrovin's `almost duality' in the theory of Frobenius manifolds and quantum cohomology must also fit a (possibly extended) version of Grothendieck-Verdier duality.

Integrating a Commitment to the Public Good into the Institutional Fabric: Further Lessons from the Field

ERIC Educational Resources Information Center

Harkavy, Ira; Hartley, Matthew

2012-01-01

This essay builds on and extends earlier research and writing that the authors have done, trying to understand how a commitment to local engagement, which is the term commonly used at the University of Pennsylvania (Penn), becomes embedded in the core work of the institution. Their inquiries have been guided by social psychologist Kurt Lewin's…

Dark Matter and Extragalactic Gas Clouds in the NGC 4532/DDO 137 System

NASA Technical Reports Server (NTRS)

Hoffman, G. L.; Lu, N. Y.; Salpeter, E. E.; Connell, B. M.

1998-01-01

H I synthesis mapping of NGC 4532 and DDO 137, a pair of Sm galaxies on the edge of the Virgo cluster, is used to determine rotation curves for each of the galaxies and to resolve the structure and kinematics of three extragalactic H I clouds embedded in an extended envelope of diffuse HI discovered in earlier Arecibo studies of the system.

Can the University Escape from the Labyrinth of Technology? Part 4: Extending the Strategy to Medicine, the Social Sciences, and the University

ERIC Educational Resources Information Center

Vanderburg, Willem H.

2006-01-01

This fourth part outlines a strategy for overcoming the limitations of the knowledge system for engineering by combining intellectual maps, preventive approaches, umbrella concepts, and round tables as described in the earlier parts. A discussion of the issues faced by modern medicine illustrates the paradigmatic nature of the diagnosis and…

Attentional Differences between Groups of Preschool Children Differentiated by Teacher Ratings of Attention and Hyperactivity

ERIC Educational Resources Information Center

Wilding, John; Burke, Kate

2006-01-01

This study aimed to extend earlier work (Wilding, Munir, & Cornish, 2001; Wilding, 2003) which showed that children (aged 6-15) who were rated by their teachers as having poor attentional ability made more errors on a visual search task than children rated as having good attentional ability. The present study used a simpler version of the search…

Estimating the Return to College Selectivity over the Career Using Administrative Earnings Data. NBER Working Paper No. 17159

ERIC Educational Resources Information Center

Dale, Stacy; Krueger, Alan B.

2011-01-01

We estimate the monetary return to attending a highly selective college using the College and Beyond (C&B) Survey linked to Detailed Earnings Records from the Social Security Administration (SSA). This paper extends earlier work by Dale and Krueger (2002) that examined the relationship between the college that students attended in 1976 and the…

Effects of Concept Mapping Instruction on the Vocabulary Acquisition Skills of Seventh-Graders with Mild Disabilities: A Replication Study

ERIC Educational Resources Information Center

Palmer, Jessica; Boon, Richard T.; Spencer, Vicky G.

2014-01-01

The present investigation replicates and extends an earlier study comparing 2 conditions, a dictionary approach versus a concept mapping model, on the learning of vocabulary words among 4 students with mild disabilities (i.e., emotional and/or behavioral disorders and other health impairments) attending a middle school. An A-B-A-B design was used…

Forecasting ENSO events: A neural network-extended EOF approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tangang, F.T.; Tang, B.; Monahan, A.H.

The authors constructed neural network models to forecast the sea surface temperature anomalies (SSTA) for three regions: Nino 4. Nino 3.5, and Nino 3, representing the western-central, the central, and the eastern-central parts of the equatorial Pacific Ocean, respectively. The inputs were the extended empirical orthogonal functions (EEOF) of the sea level pressure (SLP) field that covered the tropical Indian and Pacific Oceans and evolved for a duration of 1 yr. The EEOFs greatly reduced the size of the neural networks from those of the authors` earlier papers using EOFs. The Nino 4 region appeared to be the best forecastedmore » region, with useful skills up to a year lead time for the 1982-93 forecast period. By network pruning analysis and spectral analysis, four important inputs were identified: modes 1, 2, and 6 of the SLP EEOFs and the SSTA persistence. Mode 1 characterized the low-frequency oscillation (LFO, with 4-5-yr period), and was seen as the typical ENSO signal, while mode 2, with a period of 2-5 yr, characterized the quasi-biennial oscillation (QBO) plus the LFO. Mode 6 was dominated by decadal and interdecadal variations. Thus, forecasting ENSO required information from the QBO, and the decadal-interdecadal oscillations. The nonlinearity of the networks tended to increase with lead time and to become stronger for the eastern regions of the equatorial Pacific Ocean. 35 refs., 14 figs., 4 tabs.« less

Is saccade preparation required for inhibition of return (IOR)?

PubMed

Michalczyk, Łukasz; Paszulewicz, Jakub; Bielas, Jacek; Wolski, Piotr

2018-02-05

The effect of slower responses to validly than invalidly cued targets is known as inhibition of return (IOR). Opposing accounts of IOR have been proposed: one postulates a singular phenomenon explained by oculomotor mechanisms alone, while the other, more diverse account postulates both perceptual-cognitive and motor factors. In our research we considered the relation between motor programming and IOR. In an extended replication of an earlier study, using an eye abduction technique we restricted eye movement in the temporal half-space; this resulted in IOR attenuation in that area, compared to the unrestricted, nasal part of the visual field. Our results contradict the earlier result and demonstrate that IOR does depend on preparation of eye movement, as predicted by the oculomotor priming hypothesis. Copyright © 2017 Elsevier B.V. All rights reserved.

Guidance on the selection of cohorts for the extended one-generation reproduction toxicity study (OECD test guideline 443).

PubMed

Moore, Nigel P; Beekhuijzen, Manon; Boogaard, Peter J; Foreman, Jennifer E; North, Colin M; Palermo, Christine; Schneider, Steffen; Strauss, Volker; van Ravenzwaay, Bennard; Poole, Alan

2016-10-01

The extended one-generation reproduction toxicity study (EOGRTS; OECD test guideline 433) is a new and technically complex design to evaluate the putative effects of chemicals on fertility and development, including effects upon the developing nervous and immune systems. In addition to offering a more comprehensive assessment of developmental toxicity, the EOGRTS offers important improvements in animal welfare through reduction and refinement in a modular study design. The challenge to the practitioner is to know how the modular aspects of the study should be triggered on the basis of prior knowledge of a particular chemical, or on earlier findings in the EOGRTS itself, requirements of specific regulatory frameworks notwithstanding. The purpose of this document is to offer guidance on science-based triggers for these extended evaluations. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

On the orientation of pre-islamic temples of north Africa: a re-appraisal (new data in Africa proconsularis)

NASA Astrophysics Data System (ADS)

Belmonte, J. A.; Gaspar, A. T.; Betancort, A. P.; Marrero, R.

Since the late 1990s, our research group has embarked on a systematic archaeoastronomical study of archaeological sites in the Maghreb. Earlier campaigns were devoted to Tunisia, Morocco and Libya (see e.g. Belmonte et. Al.1998, 1999 and 2002). In this short report we will present part of the data obtained in a field campaign carried out in winter 2002, analyzing the results yielded on early 50 ancient sacred structures (temples, churches, earlier mosques and mausoleums) of an extended area in Northern Tunisia (ancient Africa Proconsularis). These data were not discussed in previous reports on similar structures (e.g. Esteban at.al.2001) , although in a previous paper (Belmonte et.al.2003) we reported our results on the contemporary measured megalithic monuments. This paper will present the data of more than 30 temples and mausoleums of Roman era, 10 pre-Islamic Christian churches and a few earlier mosques. These new data will be discussed together with those obtained in previous campaigns in an attempt to shed some light on the possibility of astronomical alignments within this extended set of monuments (more than a hundred). Our results show that some astronomical patterns could be interpreted as solar ones. Interestingly, this solar tendency was continued by Christian churches until the arrival of Islam. This is a common feature to the other regions of early Christianity (see e.g. Romano 1992). Other curious patterns, including the planning of important cities could presumably be associated to the brightest stars of the sky, Sirius and Canopus. Finally, we will analyse how this astronomical tendencies managed to survive within the first Islamic orienting traditions.

Effective collision strengths for fine-structure forbidden transitions among the 3s^23p^3 levels of K V

NASA Astrophysics Data System (ADS)

Bell, Kenneth; Wilson, Nigel

2001-05-01

Electron temperatures and densities are difficult to determine in many astrophysical plasmas. However, it is well known that diagnostics on forbidden line intensity ratios for ions in the phosphorous isoelectronic sequence are of great importance in astrophysics, particularly for nebulae. A key element in the analysis is highly accurate atomic data. In this work we extend the earlier calculations of Butler, Zeippen and Le Bourlot (Astron. Astrophys. 203 189 (1988)) on electron scattering by K v. We have obtained effective collision strengths for a wide range of electron temperatures using the R-matrix method. Twenty-two LS target eigenstates are included in the expansion of the total wavefunction, consisting of the seven n=3 states with configuration 3s^23p^3 and 3s3p^4, twelve n=3 states with configuration 3s^23p^23d, and three n=4 states with configuration 3s^23p^24s. The fine-structure collision strengths have been obtained by transforming to a jj-coupling scheme using the JAJOM program of Saraph (Comp. Phys. Commun. 15 247 (1978)) and have been determined at a sufficiently fine energy mesh to delineate properly the resonance structure. Results for both collision strengths and for effective collision strengths will be presented at the conference and comparison will be made with the earlier work.

Six years after the NRC review of EPA's Draft IRIS Toxicological Review of Formaldehyde: Regulatory implications of new science in evaluating formaldehyde leukemogenicity.

PubMed

Mundt, Kenneth A; Gentry, P Robinan; Dell, Linda D; Rodricks, Joseph V; Boffetta, Paolo

2018-02-01

Shortly after the International Agency for Research on Cancer (IARC) determined that formaldehyde causes leukemia, the United States Environmental Protection Agency (EPA) released its Draft IRIS Toxicological Review of Formaldehyde ("Draft IRIS Assessment"), also concluding that formaldehyde causes leukemia. Peer review of the Draft IRIS Assessment by a National Academy of Science committee noted that "causal determinations are not supported by the narrative provided in the draft" (NRC 2011). They offered recommendations for improving the Draft IRIS assessment and identified several important research gaps. Over the six years since the NRC peer review, significant new science has been published. We identify and summarize key recommendations made by NRC and map them to this new science, including extended analysis of epidemiological studies, updates of earlier occupational cohort studies, toxicological experiments using a sensitive mouse strain, mechanistic studies examining the role of exogenous versus endogenous formaldehyde in bone marrow, and several critical reviews. With few exceptions, new findings are consistently negative, and integration of all available evidence challenges the earlier conclusions that formaldehyde causes leukemia. Given formaldehyde's commercial importance, environmental ubiquity and endogenous production, accurate hazard classification and risk evaluation of whether exposure to formaldehyde from occupational, residential and consumer products causes leukemia are critical. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Changes in vegetation phenology on the Mongolian Plateau and their climatic determinants.

PubMed

Miao, Lijuan; Müller, Daniel; Cui, Xuefeng; Ma, Meihong

2017-01-01

Climate change affects the timing of phenological events, such as the start, end, and length of the growing season of vegetation. A better understanding of how the phenology responded to climatic determinants is important in order to better anticipate future climate-ecosystem interactions. We examined the changes of three phenological events for the Mongolian Plateau and their climatic determinants. To do so, we derived three phenological metrics from remotely sensed vegetation indices and associated these with climate data for the period of 1982 to 2011. The results suggested that the start of the growing season advanced by 0.10 days yr-1, the end was delayed by 0.11 days yr-1, and the length of the growing season expanded by 6.3 days during the period from 1982 to 2011. The delayed end and extended length of the growing season were observed consistently in grassland, forest, and shrubland, while the earlier start was only observed in grassland. Partial correlation analysis between the phenological events and the climate variables revealed that higher temperature was associated with an earlier start of the growing season, and both temperature and precipitation contributed to the later ending. Overall, our findings suggest that climate change will substantially alter the vegetation phenology in the grasslands of the Mongolian Plateau, and likely also in biomes with similar environmental conditions, such as other semi-arid steppe regions.

Molecular deletion mapping of the Y chromosome in males with idiopathic azoospermia reveals a new class of microdeletions located in middle Yq11

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farah, S.B.; Ramos, C.F.; Bortoletto, R.K.

1994-09-01

Microdeletions in proximal and distal Yq11 found {open_quotes}de novo{close_quotes} in males with idiopathic azoospermia or a severe oligospermia suggested that these Y mutations interrupt the gene structure(s) of a spermatogenesis function located in Yq11 and defined earlier as AZF. Using an extended interval map, dividing Yq11 into 22 subintervals (D1-D22) a third class of microdeletions could now be mapped in middle Yq11. It was found {open_quotes}de novo{close_quotes} in two sterile males with idiopathic azoospermia. Histological analysis of testes tissue sections of both males reveals arrest of spermatogenesis during the pachytene stage. Y-mutations in proximal Yq11 were usually associated to anmore » arrest of spermatogenesis before the proliferation phase of spermatogonia; the corresponding Y gene was defined as {open_quotes}AZFa{close_quotes}. It is, therefore, assumed that the new class of microdeletions, observed now in the middle of Yq11, disrupt another Y spermatogenesis gene expressed during the spermatocyte stage and defined earlier as {open_quotes}AZFb{close_quotes}. Experimental evidence presented during the meeting will try to confirm this view discussing a series of Y genes (AZFa,b,c,...) in Yq11 functioning at different stages during human spermatogenesis.« less

Electron-impact excitation of the BΣ1u+ and CΠ1u electronic states of H2

NASA Astrophysics Data System (ADS)

Kato, H.; Kawahara, H.; Hoshino, M.; Tanaka, H.; Campbell, L.; Brunger, M. J.

2008-06-01

Differential and integral cross sections for electron-impact excitation of the dipole-allowed BΣ1u+ and CΠ1u electronic states of molecular hydrogen have been measured. The differential cross sections were determined by analysis of normalized energy-loss spectra obtained using a crossed-beam apparatus at the electron-impact energies of 40, 100, and 200 eV. Integral cross sections were subsequently derived from these data. The present work was undertaken in order to investigate some ambiguities between earlier experimental data and recent BEf-scaled cross sections as defined and calculated by Kim [J. Chem. Phys. 126, 064305 (2007)] and also to extend the energy range of the available data. Optical oscillator strengths, also determined as a part of the present investigation, were found to be in fair accordance with previous measurements and some calculations.

Magnetic field studies at jupiter by voyager 1: preliminary results.

PubMed

Ness, N F; Acuna, M H; Lepping, R P; Burlaga, L F; Behannon, K W; Neubauer, F M

1979-06-01

Results obtained by the Goddard Space Flight Center magnetometers on Voyager 1 are described. These results concern the large-scale configuration of the Jovian bow shock and magnetopause, and the magnetic field in both the inner and outer magnetosphere. There is evidence that a magnetic tail extending away from the planet on the nightside is formed by the solar wind-Jovian field interaction. This is much like Earth's magnetosphere but is a new configuration for Jupiter's magnetosphere not previously considered from earlier Pioneer data. We report on the analysis and interpretation of magnetic field perturbations associated with intense electrical currents (approximately 5 x 10(6) amperes) flowing near or in the magnetic flux tube linking Jupiter with the satellite Jo and induced by the relative motion between Io and the corotating Jovian magnetosphere. These currents may be an important source of heating the ionosphere and interior of Io through Joule dissipation.

Preliminary analysis of an ultraviolet Hubble Space Telescope faint object camera image of the center of M31

NASA Technical Reports Server (NTRS)

King, I. R.; Deharveng, J. M.; Albrecht, R.; Barbieri, C.; Blades, J. C.; Boksenberg, A.; Crane, P.; Disney, M. J.; Jakobsen, P.; Kamperman, T. M.

1992-01-01

A 5161 s exposure was taken with the FOC on the central 44 arcsec of M31, through a filter centered at 1750 A. Much of the light is redleak from visible wavelengths, but nearly half of it is genuine UV. The image shows the same central peak found earlier by Stratoscope, with a somewhat steeper dropoff outside that peak. More than 100 individual objects are seen, some pointlike and some slightly extended. We identify them as post-asymptotic giant branch stars, some of them surrounded by a contribution from their accompanying planetary nebulae. These objects contribute almost a fifth of the total UV light, but fall far short of accounting for all of it. We suggest that the remainder may result from the corresponding evolutionary tracks in a population more metal-rich than solar.

New Archeomagnetic Directional Records From Iron Age Southern Africa (ca. 425-1550 CE) and Implications for the South Atlantic Anomaly

NASA Astrophysics Data System (ADS)

Hare, Vincent J.; Tarduno, John A.; Huffman, Thomas; Watkeys, Michael; Thebe, Phenyo C.; Manyanga, Munyaradzi; Bono, Richard K.; Cottrell, Rory D.

2018-02-01

The paucity of Southern Hemisphere archeomagnetic data limits the resolution of paleosecular variation models. At the same time, important changes in the modern and historical field, including the recent dipole decay, appear to originate in this region. Here a new directional record from southern Africa is presented from analysis of Iron Age (ca. 425-1550 CE) archeological materials, which extends the regional secular variation curve back to the first millennium. Previous studies have identified a period of rapid directional change between 1225 and ˜1550 CE. The new data allow us to identify an earlier period of relatively rapid change between the sixth and seventh centuries CE. Implications for models of recurrent flux expulsion at the core-mantle boundary are discussed. In addition, we identify a possible relationship of changes recorded in these African data with archeomagnetic jerks.

Mineral exploration potential of ERTS-1 data

NASA Technical Reports Server (NTRS)

Brewer, W. A. (Principal Investigator); Erskine, M. C., Jr.; Prindle, R. O.

1973-01-01

The author has identified the following significant results. Further analysis of ERTS-1 MSS imagery of Arizona has led to division of the earlier reported three major regional fault/fracture systems into eight subdivisions. These are: System A - N40E to N50E; System B - N50W; System C - N35W; System D - N65E to N75E; System E - N-E; System F - N25W average; System G - N75W average; and System H - close to E-W. Their individual significance to known porphyry coppers and correlation to the Wasatch-Jerome and Front Orogens, the Texas Zone and Basin Range topography is postulated in the report. In this study area of Arizona the ERTS-1 mapped structural trends confirm and greatly extend some concepts of porphyry copper distribution based on prior geologic knowledge of major structural trends.

AGB subpopulations in the nearby globular cluster NGC 6397

NASA Astrophysics Data System (ADS)

MacLean, B. T.; Campbell, S. W.; De Silva, G. M.; Lattanzio, J.; D'Orazi, V.; Cottrell, P. L.; Momany, Y.; Casagrande, L.

2018-03-01

It has been well established that Galactic Globular clusters (GCs) harbour more than one stellar population, distinguishable by the anticorrelations of light-element abundances (C-N, Na-O, and Mg-Al). These studies have been extended recently to the asymptotic giant branch (AGB). Here, we investigate the AGB of NGC 6397 for the first time. We have performed an abundance analysis of high-resolution spectra of 47 red giant branch (RGB) and eight AGB stars, deriving Fe, Na, O, Mg, and Al abundances. We find that NGC 6397 shows no evidence of a deficit in Na-rich AGB stars, as reported for some other GCs - the subpopulation ratios of the AGB and RGB in NGC 6397 are identical, within uncertainties. This agrees with expectations from stellar theory. This GC acts as a control for our earlier work on the AGB of M4 (with contrasting results), since the same tools and methods were used.

Investigation of Critical Burning of Fuel Droplets. [of liquid rocket propellant

NASA Technical Reports Server (NTRS)

Chanin, S. P.; Shearer, A. J.; Faeth, G. M.

1976-01-01

An earlier analysis for the combustion response of a liquid monopropellant strand (hydrazine) was extended to consider individual droplets and sprays. While small drops gave low or negative response, large droplets provided response near unity at low frequencies, with the response declining at frequencies greater than the characteristic liquid phase frequency. Temperature gradients in the liquid phase resulted in response peaks greater than unity. A second response peak was found for large drops which corresponded to gas phase transient effects. Spray response was generally reduced from the response of the largest injected droplet, however, even a small percentage of large droplets can yield appreciable response. An apparatus was designed and fabricated to allow observation of bipropellant fuel spray combustion at elevated pressures. A locally homogeneous model was developed to describe this combustion process which allows for high pressure phenomena associated with the thermodynamic critical point.

The role of fear in delusions of the paranormal.

PubMed

Lange, R; Houran, J

1999-03-01

Based on an extended process model derived from attribution theory, we hypothesized that pervasive and persistent delusions of the paranormal are characterized by the existence of a positive (self-reinforcing), rather than a negative (self-correcting), feedback loop involving paranormal beliefs, fears, and experiences, as moderated by gender and tolerance of ambiguity. A cross-cultural sample of "international" students who reported poltergeist-like experiences showing high fear of the paranormal was identified. As in earlier research, path analysis showed statistically significant and positive effects of belief on experience and/or fear on belief. However, paranormal experience now had a positive effect on fear as well. Thus, as predicted, increased fear removes the option of neutralizing ambiguous events by labeling them as "paranormal." Although female subjects showed significantly greater fear of the paranormal than male subjects, there is no evidence that the nature of the delusional process is gender specific.

Computational cost for detecting inspiralling binaries using a network of laser interferometric detectors

NASA Astrophysics Data System (ADS)

Pai, Archana; Bose, Sukanta; Dhurandhar, Sanjeev

2002-04-01

We extend a coherent network data-analysis strategy developed earlier for detecting Newtonian waveforms to the case of post-Newtonian (PN) waveforms. Since the PN waveform depends on the individual masses of the inspiralling binary, the parameter-space dimension increases by one from that of the Newtonian case. We obtain the number of templates and estimate the computational costs for PN waveforms: for a lower mass limit of 1Msolar, for LIGO-I noise and with 3% maximum mismatch, the online computational speed requirement for single detector is a few Gflops; for a two-detector network it is hundreds of Gflops and for a three-detector network it is tens of Tflops. Apart from idealistic networks, we obtain results for realistic networks comprising of LIGO and VIRGO. Finally, we compare costs incurred in a coincidence detection strategy with those incurred in the coherent strategy detailed above.

The genetic prehistory of the Baltic Sea region.

PubMed

Mittnik, Alissa; Wang, Chuan-Chao; Pfrengle, Saskia; Daubaras, Mantas; Zariņa, Gunita; Hallgren, Fredrik; Allmäe, Raili; Khartanovich, Valery; Moiseyev, Vyacheslav; Tõrv, Mari; Furtwängler, Anja; Andrades Valtueña, Aida; Feldman, Michal; Economou, Christos; Oinonen, Markku; Vasks, Andrejs; Balanovska, Elena; Reich, David; Jankauskas, Rimantas; Haak, Wolfgang; Schiffels, Stephan; Krause, Johannes

2018-01-30

While the series of events that shaped the transition between foraging societies and food producers are well described for Central and Southern Europe, genetic evidence from Northern Europe surrounding the Baltic Sea is still sparse. Here, we report genome-wide DNA data from 38 ancient North Europeans ranging from ~9500 to 2200 years before present. Our analysis provides genetic evidence that hunter-gatherers settled Scandinavia via two routes. We reveal that the first Scandinavian farmers derive their ancestry from Anatolia 1000 years earlier than previously demonstrated. The range of Mesolithic Western hunter-gatherers extended to the east of the Baltic Sea, where these populations persisted without gene-flow from Central European farmers during the Early and Middle Neolithic. The arrival of steppe pastoralists in the Late Neolithic introduced a major shift in economy and mediated the spread of a new ancestry associated with the Corded Ware Complex in Northern Europe.

Evaluation of the William S. Hall Psychiatric Institute Clinical Psychology Internship: a replication and extension.

PubMed

Stader, Sandra R; Myers, DeRosset; Forand, Angela Q; Holmes, George R; McNulty, George F; Frey, Linda; Bolton, Staci S

2010-12-01

This study extends three earlier investigations involving participants who completed their predoctoral clinical psychology internship at the William S. Hall Psychiatric Institute. Intern graduates (N = 37) evaluated how effectively their internship training prepared them for seven aspects of their current work as practicing psychologists. Participants also rated the relevancy of 24 different internship training experiences to their current work and how much these experiences contributed to their development as clinical psychologists. The present study, in conjunction with the three previous studies, covers most of the 40-year period since the inception of the internship program. Analysis of the current data indicates the internship has improved over time and was deemed an exceptional training experience by its graduates. Findings may be of particular interest to internship directors and faculty interested in improving their training program and those who plan to conduct a self-study to maintain their accreditation for clinical psychology internship.

A wind tunnel investigation of the wake near the trailing edge of a deflected externally blown flap. [on a jet powered STOL transport aircraft

NASA Technical Reports Server (NTRS)

Johnson, W. G., Jr.; Kardas, G. E.

1974-01-01

The model tested was a general research model of a swept-wing, jet-powered STOL transport with externally blown flaps. The model was tested with four engine simulators mounted on pylons under the wing. Tests were conducted in the V/STOL tunnel over an angle of attack range of 0 deg to 16 deg and a thrust coefficient range from 0 to approximately 4 at a Reynolds number of 0.461 x 1 million based on the wing reference chord. The results of this investigation are presented primarily as plots of the individual velocity vectors obtained from the wake survey. These data are used to extend an earlier analysis to isolate the effects of the engine thrust on the behavior of the flow at the flap trailing edge. Results of a comparison with a jet-flap theory are also shown.

Local social norms and military sexual stressors: do senior officers' norms matter?

PubMed

Murdoch, Maureen; Pryor, John Barron; Polusny, Melissa Anderson; Gackstetter, Gary D; Ripley, Diane Cowper

2009-10-01

To examine the relative importance of harassment-tolerant norms emanating from troops senior officers, immediate supervisors, and units on troops' sexual stressor experiences and to see whether associations differed by sex. Cross-sectional survey of all 681 willing and confirmed active duty troops enrolled in the VA National Enrollment Database between 1998 and 2002. Findings extended an earlier analysis. After adjusting for other significant correlates, senior officers' perceived tolerance of sexual harassment was not associated with the severity of sexual harassment troops reported (p = 0.64) or with the numbers of sexual identity challenges they reported (p = 0.11). Harassment-tolerant norms emanating from troops' units and immediate supervisors were associated with reporting more severe sexual harassment and more sexual identity challenges (all p < 0.003). Findings generalized across sex. Senior officers' norms did not appear to affect troops' reports of military sexual stressors, but unit norms and immediate supervisors' norms did.

Micromechanical predictions of crack propagation and fracture energy in a single fiber boron/aluminum model composite

NASA Technical Reports Server (NTRS)

Adams, D. F.; Mahishi, J. M.

1982-01-01

The axisymmetric finite element model and associated computer program developed for the analysis of crack propagation in a composite consisting of a single broken fiber in an annular sheath of matrix material was extended to include a constant displacement boundary condition during an increment of crack propagation. The constant displacement condition permits the growth of a stable crack, as opposed to the catastropic failure in an earlier version. The finite element model was refined to respond more accurately to the high stresses and steep stress gradients near the broken fiber end. The accuracy and effectiveness of the conventional constant strain axisymmetric element for crack problems was established by solving the classical problem of a penny-shaped crack in a thick cylindrical rod under axial tension. The stress intensity factors predicted by the present finite element model are compared with existing continuum results.

Factors Influencing Breastfeeding Duration in a Military Environment

DTIC Science & Technology

1999-01-01

The American Academy of Pediatrics ( AAP ) recommends breastfeeding for at least 12 months, and as long as mother and child mutually desire thereafter...of the superiority of breastmilk, many women choose to bottle-feed or to cease breastfeeding earlier than recommended by the AAP . The national average...34 Breastfeeding and the Use", 1997). Benefits of breastfeeding are multifaceted and extend beyond mother and baby into society. In spite of evidence

How do plant cell walls extend?

NASA Technical Reports Server (NTRS)

Cosgrove, D. J.

1993-01-01

This article briefly summarizes recent work that identifies the biophysical and biochemical processes that give rise to the extension of plant cell walls. I begin with the biophysical notion of stress relaxation of the wall and follow with recent studies of wall enzymes thought to catalyze wall extension and relaxation. Readers should refer to detailed reviews for more comprehensive discussion of earlier literature (Taiz, 1984; Carpita and Gibeaut, 1993; Cosgrove, 1993).

Replacement Capability Options for the United States Space Shuttle

DTIC Science & Technology

2013-09-01

extended periods, and to expand our knowledge of solar astronomy well beyond Earth-based observations.” During the Skylab missions, both the man...determined Skylab’s orbit was no longer stable due to higher than predicted solar activity. Therefore, Skylab had to be de-orbited earlier than...Module houses the oxygen, life support, power, communications, thermal control, and propulsions systems. The solar arrays for the Soyuz are also

Radiation Testing, Characterization and Qualification Challenges for Modern Microelectronics and Photonics Devices and Technologies

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.; Cohn, Lewis M.

2008-01-01

At an earlier conference we discussed a selection of the challenges for radiation testing of modern semiconductor devices focusing on state-of-the-art CMOS technologies. In this presentation, we extend this discussion focusing on the following areas: (1) Device packaging, (2) Evolving physical single even upset mechanisms, (3) Device complexity, and (4) the goal of understanding the limitations and interpretation of radiation testing results.

LETTER TO THE EDITOR: On the relations between the zero-field splitting parameters in the extended Stevens operator notation and the conventional ones used in EMR for orthorhombic and lower symmetry

NASA Astrophysics Data System (ADS)

Rudowicz, C.

2000-06-01

Electron magnetic resonance (EMR) studies of paramagnetic species with the spin S ≥ 1 at orthorhombic symmetry sites require an axial zero-field splitting (ZFS) parameter and a rhombic one of the second order (k = 2), whereas at triclinic sites all five ZFS (k = 2) parameters are expressed in the crystallographic axis system. For the spin S ≥ 2 also the higher-order ZFS terms must be considered. In the principal axis system, instead of the five ZFS (k = 2) parameters, the two principal ZFS values can be used, as for orthorhombic symmetry; however, then the orientation of the principal axes with respect to the crystallographic axis system must be provided. Recently three serious cases of incorrect relations between the extended Stevens ZFS parameters and the conventional ones have been identified in the literature. The first case concerns a controversy concerning the second-order rhombic ZFS parameters and was found to have lead to misinterpretation, in a review article, of several values of either E or b22 published earlier. The second case concerns the set of five relations between the extended Stevens ZFS parameters bkq and the conventional ones Dij for triclinic symmetry, four of which turn out to be incorrect. The third case concerns the omission of the scaling factors fk for the extended Stevens ZFS parameters bkq. In all cases the incorrect relations in question have been published in spite of the earlier existence of the correct relations in the literature. The incorrect relations are likely to lead to further misinterpretation of the published values of the ZFS parameters for orthorhombic and lower symmetry. The purpose of this paper is to make the spectroscopists working in the area of EMR (including EPR and ESR) and related spectroscopies aware of the problem and to reduce proliferation of the incorrect relations.

Resolving the orthographic ambiguity during visual word recognition in Arabic: an event-related potential investigation

PubMed Central

Taha, Haitham; Khateb, Asaid

2013-01-01

The Arabic alphabetical orthographic system has various unique features that include the existence of emphatic phonemic letters. These represent several pairs of letters that share a phonological similarity and use the same parts of the articulation system. The phonological and articulatory similarities between these letters lead to spelling errors where the subject tends to produce a pseudohomophone (PHw) instead of the correct word. Here, we investigated whether or not the unique orthographic features of the written Arabic words modulate early orthographic processes. For this purpose, we analyzed event-related potentials (ERPs) collected from adult skilled readers during an orthographic decision task on real words and their corresponding PHw. The subjects' reaction times (RTs) were faster in words than in PHw. ERPs analysis revealed significant response differences between words and the PHw starting during the N170 and extending to the P2 component, with no difference during processing steps devoted to phonological and lexico-semantic processing. Amplitude and latency differences were found also during the P6 component which peaked earlier for words and where source localization indicated the involvement of the classical left language areas. Our findings replicate some of the previous findings on PHw processing and extend them to involve early orthographical processes. PMID:24348367

A first-principles analytical theory for 2D magnetic reconnection in electron and Hall MHD.

NASA Astrophysics Data System (ADS)

Zocco, A.; Simakov, A. N.; Chacon, L.

2007-11-01

While the relevance of two-fluid effects in fast magnetic reconnection is well-known,ootnotetextJ. Birn et al., J. Geophys. Res., 106 (A3), pp. 3715--3719 (2001) a first-principles theory --akin to Sweet and Parker's in resistive MHD-- has been elusive. Here, we present such a first principles steady-state theory for electron MHD,ootnotetextL. Chac'on, A. N. Simakov, A. Zocco, Phys. Rev. Lett., submitted and its extension to Hall.ootnotetextA. N. Simakov, L. Chac'on, in preparation The theory discretizes the extended MHD equations at the reconnection site, leading to a set of time-dependent ODEs. Their steady-state analysis provides predictions for the scaling of relevant quantities with the dissipation coefficients (e.g, resistivity and hyper-resistivity) and other relevant parameters. In particular, we will show that EMHD admits both elongated and open-X point configurations of the reconnection region, and that the reconnection rate Ez can be shown not to scale explicitly with the dissipation parameters. This analytic result confirms earlier computational work on the possibility of fast (dissipation-independent) magnetic reconnection in EMHD. We have extended the EMHD results to Hall MHD, and have found a general scaling law for the reconnection rate (and associated length scales) that bridges the gap between resistive and EMHD.

Inclusive cross section and double-helicity asymmetry for $$\\pi^{0}$$ production at midrapidity in $p$$+$$p$ collisions at $$\\sqrt{s}=510$$ GeV

DOE PAGES

Adare, A.

2016-01-07

PHENIX measurements are presented for the cross section and double-helicity asymmetry (ALL) in inclusive π⁰ production at midrapidity from p+p collisions at √s = 510 GeV from data taken in 2012 and 2013 at the Relativistic Heavy Ion Collider. The next-to-leading-order perturbativequantum- chromodynamics theory calculation is in excellent agreement with the presented cross section results. The calculation utilized parton-to-pion fragmentation functions from the recent DSS14 global analysis, which prefer a smaller gluon-to-pion fragmentation function. The π⁰A LL results follow an increasingly positive asymmetry trend with pT and √s with respect to the predictions and are in excellent agreement with themore » latest global analysis results. This analysis incorporated earlier results on π0 and jet A LL, and suggested a positive contribution of gluon polarization to the spin of the proton ΔG for the gluon momentum fraction range x > 0.05. The data presented here extend to a currently unexplored region, down to x 0.01, and thus provide additional constraints on the value of ΔG.« less

Inclusive cross section and double-helicity asymmetry for π0 production at midrapidity in p +p collisions at √{s }=510 GeV

NASA Astrophysics Data System (ADS)

Adare, A.; Aidala, C.; Ajitanand, N. N.; Akiba, Y.; Akimoto, R.; Alexander, J.; Alfred, M.; Aoki, K.; Apadula, N.; Aramaki, Y.; Asano, H.; Atomssa, E. T.; Awes, T. C.; Azmoun, B.; Babintsev, V.; Bai, M.; Bai, X.; Bandara, N. S.; Bannier, B.; Barish, K. N.; Bathe, S.; Baublis, V.; Baumann, C.; Baumgart, S.; Bazilevsky, A.; Beaumier, M.; Beckman, S.; Belmont, R.; Berdnikov, A.; Berdnikov, Y.; Black, D.; Blau, D. S.; Bok, J. S.; Boyle, K.; Brooks, M. L.; Bryslawskyj, J.; Buesching, H.; Bumazhnov, V.; Butsyk, S.; Campbell, S.; Chen, C.-H.; Chi, C. Y.; Chiu, M.; Choi, I. J.; Choi, J. B.; Choi, S.; Christiansen, P.; Chujo, T.; Cianciolo, V.; Citron, Z.; Cole, B. A.; Cronin, N.; Crossette, N.; Csanád, M.; Csörgő, T.; Danley, T. W.; Datta, A.; Daugherity, M. S.; David, G.; Deblasio, K.; Dehmelt, K.; Denisov, A.; Deshpande, A.; Desmond, E. J.; Ding, L.; Dion, A.; Diss, P. B.; Do, J. H.; D'Orazio, L.; Drapier, O.; Drees, A.; Drees, K. A.; Durham, J. M.; Durum, A.; Engelmore, T.; Enokizono, A.; En'yo, H.; Esumi, S.; Eyser, K. O.; Fadem, B.; Feege, N.; Fields, D. E.; Finger, M.; Finger, M.; Fleuret, F.; Fokin, S. L.; Frantz, J. E.; Franz, A.; Frawley, A. D.; Fukao, Y.; Fusayasu, T.; Gainey, K.; Gal, C.; Gallus, P.; Garg, P.; Garishvili, A.; Garishvili, I.; Ge, H.; Giordano, F.; Glenn, A.; Gong, X.; Gonin, M.; Goto, Y.; Granier de Cassagnac, R.; Grau, N.; Greene, S. V.; Grosse Perdekamp, M.; Gu, Y.; Gunji, T.; Guragain, H.; Hachiya, T.; Haggerty, J. S.; Hahn, K. I.; Hamagaki, H.; Hamilton, H. F.; Han, S. Y.; Hanks, J.; Hasegawa, S.; Haseler, T. O. S.; Hashimoto, K.; Hayano, R.; He, X.; Hemmick, T. K.; Hester, T.; Hill, J. C.; Hollis, R. S.; Homma, K.; Hong, B.; Hoshino, T.; Hotvedt, N.; Huang, J.; Huang, S.; Ichihara, T.; Ikeda, Y.; Imai, K.; Imazu, Y.; Inaba, M.; Iordanova, A.; Isenhower, D.; Isinhue, A.; Ivanishchev, D.; Jacak, B. V.; Jeon, S. J.; Jezghani, M.; Jia, J.; Jiang, X.; Johnson, B. M.; Joo, E.; Joo, K. S.; Jouan, D.; Jumper, D. S.; Kamin, J.; Kanda, S.; Kang, B. H.; Kang, J. H.; Kang, J. S.; Kapustinsky, J.; Kawall, D.; Kazantsev, A. V.; Key, J. A.; Khachatryan, V.; Khandai, P. K.; Khanzadeev, A.; Kihara, K.; Kijima, K. M.; Kim, C.; Kim, D. H.; Kim, D. J.; Kim, E.-J.; Kim, G. W.; Kim, H.-J.; Kim, M.; Kim, Y.-J.; Kim, Y. K.; Kimelman, B.; Kistenev, E.; Kitamura, R.; Klatsky, J.; Kleinjan, D.; Kline, P.; Koblesky, T.; Kofarago, M.; Komkov, B.; Koster, J.; Kotchetkov, D.; Kotov, D.; Krizek, F.; Kurita, K.; Kurosawa, M.; Kwon, Y.; Lacey, R.; Lai, Y. S.; Lajoie, J. G.; Lebedev, A.; Lee, D. M.; Lee, G. H.; Lee, J.; Lee, K. B.; Lee, K. S.; Lee, S.; Lee, S. H.; Leitch, M. J.; Leitgab, M.; Lewis, B.; Li, X.; Lim, S. H.; Liu, M. X.; Lynch, D.; Maguire, C. F.; Makdisi, Y. I.; Makek, M.; Manion, A.; Manko, V. I.; Mannel, E.; Maruyama, T.; McCumber, M.; McGaughey, P. L.; McGlinchey, D.; McKinney, C.; Meles, A.; Mendoza, M.; Meredith, B.; Miake, Y.; Mibe, T.; Mignerey, A. C.; Miller, A. J.; Milov, A.; Mishra, D. K.; Mitchell, J. T.; Miyasaka, S.; Mizuno, S.; Mohanty, A. K.; Mohapatra, S.; Montuenga, P.; Moon, T.; Morrison, D. P.; Moskowitz, M.; Moukhanova, T. V.; Murakami, T.; Murata, J.; Mwai, A.; Nagae, T.; Nagamiya, S.; Nagashima, K.; Nagle, J. L.; Nagy, M. I.; Nakagawa, I.; Nakagomi, H.; Nakamiya, Y.; Nakamura, K. R.; Nakamura, T.; Nakano, K.; Nattrass, C.; Netrakanti, P. K.; Nihashi, M.; Niida, T.; Nishimura, S.; Nouicer, R.; Novák, T.; Novitzky, N.; Nyanin, A. S.; O'Brien, E.; Ogilvie, C. A.; Oide, H.; Okada, K.; Orjuela Koop, J. D.; Osborn, J. D.; Oskarsson, A.; Ozaki, H.; Ozawa, K.; Pak, R.; Pantuev, V.; Papavassiliou, V.; Park, I. H.; Park, J. S.; Park, S.; Park, S. K.; Pate, S. F.; Patel, L.; Patel, M.; Peng, J.-C.; Perepelitsa, D. V.; Perera, G. D. N.; Peressounko, D. Yu.; Perry, J.; Petti, R.; Pinkenburg, C.; Pinson, R.; Pisani, R. P.; Purschke, M. L.; Qu, H.; Rak, J.; Ramson, B. J.; Ravinovich, I.; Read, K. F.; Reynolds, D.; Riabov, V.; Riabov, Y.; Richardson, E.; Rinn, T.; Riveli, N.; Roach, D.; Rolnick, S. D.; Rosati, M.; Rowan, Z.; Rubin, J. G.; Ryu, M. S.; Sahlmueller, B.; Saito, N.; Sakaguchi, T.; Sako, H.; Samsonov, V.; Sarsour, M.; Sato, S.; Sawada, S.; Schaefer, B.; Schmoll, B. K.; Sedgwick, K.; Seele, J.; Seidl, R.; Sekiguchi, Y.; Sen, A.; Seto, R.; Sett, P.; Sexton, A.; Sharma, D.; Shaver, A.; Shein, I.; Shibata, T.-A.; Shigaki, K.; Shimomura, M.; Shoji, K.; Shukla, P.; Sickles, A.; Silva, C. L.; Silvermyr, D.; Singh, B. K.; Singh, C. P.; Singh, V.; Skolnik, M.; Slunečka, M.; Snowball, M.; Solano, S.; Soltz, R. A.; Sondheim, W. E.; Sorensen, S. P.; Sourikova, I. V.; Stankus, P. W.; Steinberg, P.; Stenlund, E.; Stepanov, M.; Ster, A.; Stoll, S. P.; Stone, M. R.; Sugitate, T.; Sukhanov, A.; Sumita, T.; Sun, J.; Sziklai, J.; Takahara, A.; Taketani, A.; Tanaka, Y.; Tanida, K.; Tannenbaum, M. J.; Tarafdar, S.; Taranenko, A.; Tennant, E.; Tieulent, R.; Timilsina, A.; Todoroki, T.; Tomášek, M.; Torii, H.; Towell, C. L.; Towell, M.; Towell, R.; Towell, R. S.; Tserruya, I.; van Hecke, H. W.; Vargyas, M.; Vazquez-Zambrano, E.; Veicht, A.; Velkovska, J.; Vértesi, R.; Virius, M.; Vrba, V.; Vznuzdaev, E.; Wang, X. R.; Watanabe, D.; Watanabe, K.; Watanabe, Y.; Watanabe, Y. S.; Wei, F.; Whitaker, S.; White, A. S.; Wolin, S.; Woody, C. L.; Wysocki, M.; Xia, B.; Xue, L.; Yalcin, S.; Yamaguchi, Y. L.; Yanovich, A.; Yokkaichi, S.; Yoo, J. H.; Yoon, I.; You, Z.; Younus, I.; Yu, H.; Yushmanov, I. E.; Zajc, W. A.; Zelenski, A.; Zhou, S.; Zou, L.; Phenix Collaboration

2016-01-01

PHENIX measurements are presented for the cross section and double-helicity asymmetry (AL L ) in inclusive π0 production at midrapidity from p +p collisions at √{s }=510 GeV from data taken in 2012 and 2013 at the Relativistic Heavy Ion Collider. The next-to-leading-order perturbative-quantum-chromodynamics theory calculation is in excellent agreement with the presented cross section results. The calculation utilized parton-to-pion fragmentation functions from the recent DSS14 global analysis, which prefer a smaller gluon-to-pion fragmentation function. The π0AL L results follow an increasingly positive asymmetry trend with pT and √{s } with respect to the predictions and are in excellent agreement with the latest global analysis results. This analysis incorporated earlier results on π0 and jet AL L and suggested a positive contribution of gluon polarization to the spin of the proton Δ G for the gluon momentum fraction range x >0.05 . The data presented here extend to a currently unexplored region, down to x ˜0.01 , and thus provide additional constraints on the value of Δ G .

Multivariate analysis applied to the study of spatial distributions found in drug-eluting stent coatings by confocal Raman microscopy.

PubMed

Balss, Karin M; Long, Frederick H; Veselov, Vladimir; Orana, Argjenta; Akerman-Revis, Eugena; Papandreou, George; Maryanoff, Cynthia A

2008-07-01

Multivariate data analysis was applied to confocal Raman measurements on stents coated with the polymers and drug used in the CYPHER Sirolimus-eluting Coronary Stents. Partial least-squares (PLS) regression was used to establish three independent calibration curves for the coating constituents: sirolimus, poly(n-butyl methacrylate) [PBMA], and poly(ethylene-co-vinyl acetate) [PEVA]. The PLS calibrations were based on average spectra generated from each spatial location profiled. The PLS models were tested on six unknown stent samples to assess accuracy and precision. The wt % difference between PLS predictions and laboratory assay values for sirolimus was less than 1 wt % for the composite of the six unknowns, while the polymer models were estimated to be less than 0.5 wt % difference for the combined samples. The linearity and specificity of the three PLS models were also demonstrated with the three PLS models. In contrast to earlier univariate models, the PLS models achieved mass balance with better accuracy. This analysis was extended to evaluate the spatial distribution of the three constituents. Quantitative bitmap images of drug-eluting stent coatings are presented for the first time to assess the local distribution of components.

Early Vocal Development in Autism Spectrum Disorder, Rett Syndrome, and Fragile X Syndrome: Insights from Studies using Retrospective Video Analysis.

PubMed

Roche, Laura; Zhang, Dajie; Bartl-Pokorny, Katrin D; Pokorny, Florian B; Schuller, Björn W; Esposito, Gianluca; Bölte, Sven; Roeyers, Herbert; Poustka, Luise; Gugatschka, Markus; Waddington, Hannah; Vollmann, Ralf; Einspieler, Christa; Marschik, Peter B

2018-03-01

This article provides an overview of studies assessing the early vocalisations of children with autism spectrum disorder (ASD), Rett syndrome (RTT), and fragile X syndrome (FXS) using retrospective video analysis (RVA) during the first two years of life. Electronic databases were systematically searched and a total of 23 studies were selected. These studies were then categorised according to whether children were later diagnosed with ASD (13 studies), RTT (8 studies), or FXS (2 studies), and then described in terms of (a) participant characteristics, (b) control group characteristics, (c) video footage, (d) behaviours analysed, and (e) main findings. This overview supports the use of RVA in analysing the early development of vocalisations in children later diagnosed with ASD, RTT or FXS, and provides an in-depth analysis of vocalisation presentation, complex vocalisation production, and the rate and/or frequency of vocalisation production across the three disorders. Implications are discussed in terms of extending crude vocal analyses to more precise methods that might provide more powerful means by which to discriminate between disorders during early development. A greater understanding of the early manifestation of these disorders may then lead to improvements in earlier detection.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Audren, Benjamin; Lesgourgues, Julien; Benabed, Karim

Models for the latest stages of the cosmological evolution rely on a less solid theoretical and observational ground than the description of earlier stages like BBN and recombination. As suggested in a previous work by Vonlanthen et al., it is possible to tweak the analysis of CMB data in such way to avoid making assumptions on the late evolution, and obtain robust constraints on ''early cosmology parameters''. We extend this method in order to marginalise the results over CMB lensing contamination, and present updated results based on recent CMB data. Our constraints on the minimal early cosmology model are weakermore » than in a standard ΛCDM analysis, but do not conflict with this model. Besides, we obtain conservative bounds on the effective neutrino number and neutrino mass, showing no hints for extra relativistic degrees of freedom, and proving in a robust way that neutrinos experienced their non-relativistic transition after the time of photon decoupling. This analysis is also an occasion to describe the main features of the new parameter inference code MONTE PYTHON, that we release together with this paper. MONTE PYTHON is a user-friendly alternative to other public codes like COSMOMC, interfaced with the Boltzmann code CLASS.« less

Stabilizing effect of resistivity towards ELM-free H-mode discharge in lithium-conditioned NSTX

NASA Astrophysics Data System (ADS)

Banerjee, Debabrata; Zhu, Ping; Maingi, Rajesh

2017-07-01

Linear stability analysis of the national spherical torus experiment (NSTX) Li-conditioned ELM-free H-mode equilibria is carried out in the context of the extended magneto-hydrodynamic (MHD) model in NIMROD. The purpose is to investigate the physical cause behind edge localized mode (ELM) suppression in experiment after the Li-coating of the divertor and the first wall of the NSTX tokamak. Besides ideal MHD modeling, including finite-Larmor radius effect and two-fluid Hall and electron diamagnetic drift contributions, a non-ideal resistivity model is employed, taking into account the increase of Z eff after Li-conditioning in ELM-free H-mode. Unlike an earlier conclusion from an eigenvalue code analysis of these equilibria, NIMROD results find that after reduced recycling from divertor plates, profile modification is necessary but insufficient to explain the mechanism behind complete ELMs suppression in ideal two-fluid MHD. After considering the higher plasma resistivity due to higher Z eff, the complete stabilization could be explained. A thorough analysis of both pre-lithium ELMy and with-lithium ELM-free cases using ideal and non-ideal MHD models is presented, after accurately including a vacuum-like cold halo region in NIMROD to investigate ELMs.

An Extension of Analysis of Solar-Heated Thermal Wadis to Support Extended-Duration Lunar Exploration

NASA Technical Reports Server (NTRS)

Balasubramaniam, R.; Gokoglu, S. A.; Sacksteder, K. R.; Wegeng, R. S.; Suzuki, N. H.

2010-01-01

The realization of the renewed exploration of the Moon presents many technical challenges; among them is the survival of lunar surface assets during periods of darkness when the lunar environment is very cold. Thermal wadis are engineered sources of stored solar energy using modified lunar regolith as a thermal storage mass that can supply energy to protect lightweight robotic rovers or other assets during the lunar night. This paper describes an extension of an earlier analysis of performance of thermal wadis based on the known solar illumination of the Moon and estimates of producible thermal properties of modified lunar regolith. The current analysis has been performed for the lunar equatorial region and validates the formerly used 1-D model by comparison of predictions to those obtained from 2-D and 3-D computations. It includes the effects of a thin dust layer covering the surface of the wadi, and incorporating either water as a phase-change material or aluminum stakes as a high thermal conductivity material into the regolith. The calculations indicate that thermal wadis can provide the desired thermal energy and temperature control for the survival of rovers or other equipment during periods of darkness.

VISCEL: A general-purpose computer program for analysis of linear viscoelastic structures (user's manual), volume 1

NASA Technical Reports Server (NTRS)

Gupta, K. K.; Akyuz, F. A.; Heer, E.

1972-01-01

This program, an extension of the linear equilibrium problem solver ELAS, is an updated and extended version of its earlier form (written in FORTRAN 2 for the IBM 7094 computer). A synchronized material property concept utilizing incremental time steps and the finite element matrix displacement approach has been adopted for the current analysis. A special option enables employment of constant time steps in the logarithmic scale, thereby reducing computational efforts resulting from accumulative material memory effects. A wide variety of structures with elastic or viscoelastic material properties can be analyzed by VISCEL. The program is written in FORTRAN 5 language for the Univac 1108 computer operating under the EXEC 8 system. Dynamic storage allocation is automatically effected by the program, and the user may request up to 195K core memory in a 260K Univac 1108/EXEC 8 machine. The physical program VISCEL, consisting of about 7200 instructions, has four distinct links (segments), and the compiled program occupies a maximum of about 11700 words decimal of core storage.

Decreasing Cloudiness Over China: An Updated Analysis Examining Additional Variables

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaiser, D.P.

2000-01-14

As preparation of the IPCC's Third Assessment Report takes place, one of the many observed climate variables of key interest is cloud amount. For several nations of the world, there exist records of surface-observed cloud amount dating back to the middle of the 20th Century or earlier, offering valuable information on variations and trends. Studies using such databases include Sun and Groisman (1999) and Kaiser and Razuvaev (1995) for the former Soviet Union, Angel1 et al. (1984) for the United States, Henderson-Sellers (1986) for Europe, Jones and Henderson-Sellers (1992) for Australia, and Kaiser (1998) for China. The findings of Kaisermore » (1998) differ from the other studies in that much of China appears to have experienced decreased cloudiness over recent decades (1954-1994), whereas the other land regions for the most part show evidence of increasing cloud cover. This paper expands on Kaiser (1998) by analyzing trends in additional meteorological variables for Chi na [station pressure (p), water vapor pressure (e), and relative humidity (rh)] and extending the total cloud amount (N) analysis an additional two years (through 1996).« less

Development, Demonstration, and Analysis of an Integrated Iodine Hall Thruster Feed System

NASA Technical Reports Server (NTRS)

Polzin, Kurt A.; Peeples, Steven R.; Burt, Adam O.; Martin, Adam K.; Martinez, Armando; Seixal, Joao F.; Mauro, Stephanie

2016-01-01

The design of an in-space iodine-vapor-fed Hall effect thruster propellant management system is described. The solid-iodine propellant tank has unique issues associated with the microgravity environment, requiring a solution where the iodine is maintained in intimate thermal contact with the heated tank walls. The flow control valves required alterations from earlier iterations to survive for extended periods of time in the corrosive iodine-vapor environment. Materials have been selected for the entire feed system that can chemically resist the iodine vapor, with the design now featuring Hastelloy or Inconel for almost all the wetted components. An integrated iodine feed system/Hall thruster demonstration unit was fabricated and tested, with all control being handled by an onboard electronics card specifically designed to operate the feed system. Structural analysis shows that the feed system can survive launch loads after the implementation of some minor reinforcement. Flow modeling, while still requiring significant additional validation, is presented to show its potential in capturing the behavior of components in this low-flow, low-pressure system.

Installation and Testing of ITER Integrated Modeling and Analysis Suite (IMAS) on DIII-D

NASA Astrophysics Data System (ADS)

Lao, L.; Kostuk, M.; Meneghini, O.; Smith, S.; Staebler, G.; Kalling, R.; Pinches, S.

2017-10-01

A critical objective of the ITER Integrated Modeling Program is the development of IMAS to support ITER plasma operation and research activities. An IMAS framework has been established based on the earlier work carried out within the EU. It consists of a physics data model and a workflow engine. The data model is capable of representing both simulation and experimental data and is applicable to ITER and other devices. IMAS has been successfully installed on a local DIII-D server using a flexible installer capable of managing the core data access tools (Access Layer and Data Dictionary) and optionally the Kepler workflow engine and coupling tools. A general adaptor for OMFIT (a workflow engine) is being built for adaptation of any analysis code to IMAS using a new IMAS universal access layer (UAL) interface developed from an existing OMFIT EU Integrated Tokamak Modeling UAL. Ongoing work includes development of a general adaptor for EFIT and TGLF based on this new UAL that can be readily extended for other physics codes within OMFIT. Work supported by US DOE under DE-FC02-04ER54698.

Extended season for northern butterflies.

PubMed

Karlsson, Bengt

2014-07-01

Butterflies are like all insects in that they are temperature sensitive and a changing climate with higher temperatures might effect their phenology. Several studies have found support for earlier flight dates among the investigated species. A comparative study with data from a citizen science project, including 66 species of butterflies in Sweden, was undertaken, and the result confirms that most butterfly species now fly earlier during the season. This is especially evident for butterflies overwintering as adults or as pupae. However, the advancement in phenology is correlated with flight date, and some late season species show no advancement or have even postponed their flight dates and are now flying later in the season. The results also showed that latitude had a strong effect on the adult flight date, and most of the investigated species showed significantly later flights towards the north. Only some late flying species showed an opposite trend, flying earlier in the north. A majority of the investigated species in this study showed a general response to temperature and advanced their flight dates with warmer temperatures (on average they advanced their flight dates by 3.8 days/°C), although not all species showed this response. In essence, a climate with earlier springs and longer growing seasons seems not to change the appearance patterns in a one-way direction. We now see butterflies on the wings both earlier and later in the season and some consequences of these patterns are discussed. So far, studies have concentrated mostly on early season butterfly-plant interactions but also late season studies are needed for a better understanding of long-term population consequences.

Extreme warm temperatures alter forest phenology and productivity in Europe.

PubMed

Crabbe, Richard A; Dash, Jadu; Rodriguez-Galiano, Victor F; Janous, Dalibor; Pavelka, Marian; Marek, Michal V

2016-09-01

Recent climate warming has shifted the timing of spring and autumn vegetation phenological events in the temperate and boreal forest ecosystems of Europe. In many areas spring phenological events start earlier and autumn events switch between earlier and later onset. Consequently, the length of growing season in mid and high latitudes of European forest is extended. However, the lagged effects (i.e. the impact of a warm spring or autumn on the subsequent phenological events) on vegetation phenology and productivity are less explored. In this study, we have (1) characterised extreme warm spring and extreme warm autumn events in Europe during 2003-2011, and (2) investigated if direct impact on forest phenology and productivity due to a specific warm event translated to a lagged effect in subsequent phenological events. We found that warmer events in spring occurred extensively in high latitude Europe producing a significant earlier onset of greening (OG) in broadleaf deciduous forest (BLDF) and mixed forest (MF). However, this earlier OG did not show any significant lagged effects on autumnal senescence. Needleleaf evergreen forest (NLEF), BLDF and MF showed a significantly delayed end of senescence (EOS) as a result of extreme warm autumn events; and in the following year's spring phenological events, OG started significantly earlier. Extreme warm spring events directly led to significant (p=0.0189) increases in the productivity of BLDF. In order to have a complete understanding of ecosystems response to warm temperature during key phenological events, particularly autumn events, the lagged effect on the next growing season should be considered. Copyright © 2016 Elsevier B.V. All rights reserved.

Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials.

PubMed

Lees, Kennedy R; Emberson, Jonathan; Blackwell, Lisa; Bluhmki, Erich; Davis, Stephen M; Donnan, Geoffrey A; Grotta, James C; Kaste, Markku; von Kummer, Rüdiger; Lansberg, Maarten G; Lindley, Richard I; Lyden, Patrick; Murray, Gordon D; Sandercock, Peter A G; Toni, Danilo; Toyoda, Kazunori; Wardlaw, Joanna M; Whiteley, William N; Baigent, Colin; Hacke, Werner; Howard, George

2016-09-01

Thrombolytic therapy with intravenous alteplase within 4.5 hours of ischemic stroke onset increases the overall likelihood of an excellent outcome (no, or nondisabling, symptoms). Any improvement in functional outcome distribution has value, and herein we provide an assessment of the effect of alteplase on the distribution of the functional level by treatment delay, age, and stroke severity. Prespecified pooled analysis of 6756 patients from 9 randomized trials comparing alteplase versus placebo/open control. Ordinal logistic regression models assessed treatment differences after adjustment for treatment delay, age, stroke severity, and relevant interaction term(s). Treatment with alteplase was beneficial for a delay in treatment extending to 4.5 hours after stroke onset, with a greater benefit with earlier treatment. Neither age nor stroke severity significantly influenced the slope of the relationship between benefit and time to treatment initiation. For the observed case mix of patients treated within 4.5 hours of stroke onset (mean 3 hours and 20 minutes), the net absolute benefit from alteplase (ie, the difference between those who would do better if given alteplase and those who would do worse) was 55 patients per 1000 treated (95% confidence interval, 13-91; P=0.004). Treatment with intravenous alteplase initiated within 4.5 hours of stroke onset increases the chance of achieving an improved level of function for all patients across the age spectrum, including the over 80s and across all severities of stroke studied (top versus bottom fifth means: 22 versus 4); the earlier that treatment is initiated, the greater the benefit. © 2016 American Heart Association, Inc.

A time-series approach for clustering farms based on slaughterhouse health aberration data.

PubMed

Hulsegge, B; de Greef, K H

2018-05-01

A large amount of data is collected routinely in meat inspection in pig slaughterhouses. A time series clustering approach is presented and applied that groups farms based on similar statistical characteristics of meat inspection data over time. A three step characteristic-based clustering approach was used from the idea that the data contain more info than the incidence figures. A stratified subset containing 511,645 pigs was derived as a study set from 3.5 years of meat inspection data. The monthly averages of incidence of pleuritis and of pneumonia of 44 Dutch farms (delivering 5149 batches to 2 pig slaughterhouses) were subjected to 1) derivation of farm level data characteristics 2) factor analysis and 3) clustering into groups of farms. The characteristic-based clustering was able to cluster farms for both lung aberrations. Three groups of data characteristics were informative, describing incidence, time pattern and degree of autocorrelation. The consistency of clustering similar farms was confirmed by repetition of the analysis in a larger dataset. The robustness of the clustering was tested on a substantially extended dataset. This confirmed the earlier results, three data distribution aspects make up the majority of distinction between groups of farms and in these groups (clusters) the majority of the farms was allocated comparable to the earlier allocation (75% and 62% for pleuritis and pneumonia, respectively). The difference between pleuritis and pneumonia in their seasonal dependency was confirmed, supporting the biological relevance of the clustering. Comparison of the identified clusters of statistically comparable farms can be used to detect farm level risk factors causing the health aberrations beyond comparison on disease incidence and trend alone. Copyright © 2018 Elsevier B.V. All rights reserved.

Normal coordinate analysis of the vibrational spectrum of benzil molecule

NASA Astrophysics Data System (ADS)

Volovšek, V.; Colombo, L.

1993-03-01

Normal coordinate analysis is performed for the benzil molecule. Force constants of phenyl rings are transferred from earlier studies on binuclear aromatic molecules. The existance of some low-frequency internal modes have been proved, thus eliminating the earlier explanations of the excess of the bands observed in the low-frequency Raman and FIR spectra of benzil crystal.

Thermophotovoltaic space power system, phase 3

NASA Technical Reports Server (NTRS)

Horne, W. E.; Lancaster, C.

1987-01-01

Work performed on a research and development program to establish the feasibility of a solar thermophotovoltaic space power generation concept was summarized. The program was multiphased. The earlier work is summarized and the work on the current phase is detailed as it pertains to and extends the earlier work. Much of the experimental hardware and materials development was performed on the internal program. Experimental measurements and data evaluation were performed on the contracted effort. The objectives of the most recent phase were: to examine the thermal control design in order to optimize it for lightweight and low cost; to examine the concentrator optics in an attempt to relieve pointing accuracy requirements to + or - 2 degrees about the optical axis; and to use the results of the thermal and optical studies to synthesize a solar thermophotovoltaic (STPV) module design that is optimized for space application.

A Mesozoic gliding mammal from northeastern China.

PubMed

Meng, Jin; Hu, Yaoming; Wang, Yuanqing; Wang, Xiaolin; Li, Chuankui

2006-12-14

Gliding flight has independently evolved many times in vertebrates. Direct evidence of gliding is rare in fossil records and is unknown in mammals from the Mesozoic era. Here we report a new Mesozoic mammal from Inner Mongolia, China, that represents a previously unknown group characterized by a highly specialized insectivorous dentition and a sizable patagium (flying membrane) for gliding flight. The patagium is covered with dense hair and supported by an elongated tail and limbs; the latter also bear many features adapted for arboreal life. This discovery extends the earliest record of gliding flight for mammals to at least 70 million years earlier in geological history, and demonstrates that early mammals were diverse in their locomotor strategies and lifestyles; they had experimented with an aerial habit at about the same time as, if not earlier than, when birds endeavoured to exploit the sky.

Seasonal greening of an Arctic ecosystem in response to early snowmelt and climate warming: do plant community responses differ from species responses?

NASA Astrophysics Data System (ADS)

Steltzer, H.; Weintraub, M. N.; Sullivan, P.; Wallenstein, M. D.; Schimel, J.; Darrouzet-Nardi, A.; Shory, R.; Livensperger, C.; Melle, C.; Segal, A. D.; Daly, K.; Tsosie, T.

2011-12-01

In the Arctic and around the world, earlier plant growth and a longer growing season are indications that warmer temperatures or other global changes are changing the seasonality of the Earth's ecosystems. These changes in plant life histories have multi-trophic level consequences that affect food webs and biogeochemical cycles. Both the response of the plant community and of individual species can affect food and habitat resources for animals or nutrient resources for microbes. Our aim was to determine if the response of an Arctic plant community differs from individual species responses to climate change. For two years in an early snowmelt and climate warming experiment in moist acidic tussock tundra, we observed the seasonal greening of the ecosystem through near-surface measurements of surface greenness and through direct observations of the timing of plant life history events for five to eight common species that differ in growth form. In 2010 when snowmelt was accelerated by 4 days, earlier snowmelt alone or in combination with climate warming extended the life history of the dominant graminoids (E. vaginatum and C. bigelowii) and willow (S. pulchra) by 3 to 4 days. For these species, new leaf production began earlier, while the timing of senescence was similar to the controls. The effect of earlier snowmelt on the life histories of birch (B. nana) and cranberry (V. vitis-idaea) was less, but warming alone tended to increase life history duration. Warming led to earlier leaf expansion for birch and delayed senescence for cranberry. We found that the onset of greening for the plant community began four days earlier, due to the earlier loss of snow cover, and that warming accelerated the rate of greening. Peak season ended 4 days earlier in response to earlier snowmelt and climate warming, due to earlier senescence by birch. In 2011, our manipulation of the snowpack by increasing energy absorption accelerated snowmelt by 15 days and control plots were snowfree on almost the same date as in 2010. As a result greening began earlier and may have led to more varied effects on life history events among the species. In the Arctic, individual species and the plant community green up as soon as the snow is gone, creating food resources and hiding places for animals and a nutrient sink for available nitrogen. If warming temperatures also cue earlier animal development or arrival, resources should be available for most species. However, an early onset to growth can lead to early senescence for some plant species and shift the timing of peak season for the plant community. Animals that depend on late season resources may be affected, unless they can utilize the plant species for which senescence is delayed.

Annual Tropical Cyclone Report 2011

DTIC Science & Technology

2012-05-24

nuclear plant, still reeling after the tsunami disaster just a few months earlier.6 Operations at Kadena Air Base were put on hold 48 with major...conditions. Several of these early to mid-season forming TCs exhibited ―S‖ shaped, looping, or generally erratic tracks, with numerous passages near or over...track errors after -the fact to extend the data base (3) Mean forecast errors for all w arned systems in Northwest Pacific. 120-Hour Along Cross

Multiple and variable speed electrical generator systems for large wind turbines

NASA Technical Reports Server (NTRS)

Andersen, T. S.; Hughes, P. S.; Kirschbaum, H. S.; Mutone, G. A.

1982-01-01

A cost effective method to achieve increased wind turbine generator energy conversion and other operational benefits through variable speed operation is presented. Earlier studies of multiple and variable speed generators in wind turbines were extended for evaluation in the context of a specific large sized conceptual design. System design and simulation have defined the costs and performance benefits which can be expected from both two speed and variable speed configurations.

Word Frequency Effects in Dual-Task Studies Using Lexical Decision and Naming as Task 2

NASA Technical Reports Server (NTRS)

Remington, Roger W.; McCann, Robert S.; VanSelst, Mark; Shafto, Michael G. (Technical Monitor)

1997-01-01

Word frequency effects in dual-task lexical decision are variously reported to be additive or underadditive across SOA. We replicate and extend earlier lexical decision studies and find word frequency to be additive across SOA. To more directly capture lexical processing, we examine dual-task naming. Once again, we find word frequency to be additive across SOA. Lexical processing appears to be constrained by central processing limitations.

Word Effects in Dual-Task Studies Using Lexical Decision and Naming as Task 2

NASA Technical Reports Server (NTRS)

Remington, Roger; McCann, Robert S.; VanSelst, Mark; Shafto, Michael (Technical Monitor)

1997-01-01

Word frequency effects in dual-task, lexical decision are variously reported to be additive or under-additive across SOA. We replicate and extend earlier lexical decision studies and find word frequency to be additive across SOA. To more directly capture lexical processing, we examine dual-task naming. Once again we find word frequency to be additive across SOA. Lexical processing appears to be constrained by central processing limitations.

Detection of Biochemical Pathogens, Laser Stand-off Spectroscopy, Quantum Coherence, and Many Body Quantum Optics

DTIC Science & Technology

2012-02-24

AND SUBTITLE Detection of Biochemical Pathogens, Laser Stand-off Spectroscopy, Quantum Coherence, and Many Body Quantum Optics 6. AUTHORS Marian O...Maximum 200 words) Results of our earlier research in the realm of quantum optics were extended in order to solve the challenging technical problems of...efficient methods of generating UV light via quantum coherence. 14. SUBJECT TERMS Quantum coherence, quantum optics, lasers 15. NUMBER OF PAGES 15

Adaptive multitaper time-frequency spectrum estimation

NASA Astrophysics Data System (ADS)

Pitton, James W.

1999-11-01

In earlier work, Thomson's adaptive multitaper spectrum estimation method was extended to the nonstationary case. This paper reviews the time-frequency multitaper method and the adaptive procedure, and explores some properties of the eigenvalues and eigenvectors. The variance of the adaptive estimator is used to construct an adaptive smoother, which is used to form a high resolution estimate. An F-test for detecting and removing sinusoidal components in the time-frequency spectrum is also given.

Extended access to methamphetamine self-administration up-regulates dopamine transporter levels 72 hours after withdrawal in rats.

PubMed

D'Arcy, Christina; Luevano, Joe E; Miranda-Arango, Manuel; Pipkin, Joseph A; Jackson, Jonathan A; Castañeda, Eddie; Gosselink, Kristin L; O'Dell, Laura E

2016-01-01

Previous studies have demonstrated that there are persistent changes in dopamine systems following withdrawal from methamphetamine (METH). This study examined changes in striatal dopamine transporter (DAT), tyrosine hydroxylase (TH) and dopamine receptor 2 (D2) 72 h after withdrawal from METH intravenous self- administration (IVSA). Rats were given limited (1h) or extended (6h) access to METH IVSA (0.05 mg/kg/0.1 ml infusion) for 22 days. Controls did not receive METH IVSA. The rats given extended access to IVSA displayed higher METH intake during the first hour of drug access compared to rats given limited access. Extended access to METH also produced a concomitant increase in striatal DAT levels relative to drug-naïve controls. There were no changes in TH or D2 levels across groups. Previous studies have reported a decrease in striatal DAT levels during protracted periods (>7 days) of withdrawal from METH IVSA. This study extends previous work by showing an increase in striatal DAT protein expression during an earlier time point of withdrawal from this drug. These results are an important step toward understanding the dynamic changes in dopamine systems that occur during different time points of withdrawal from METH IVSA. Copyright © 2015 Elsevier B.V. All rights reserved.

Timing and Variability of Postpartum Sleep in Relation to Daytime Performance

PubMed Central

McBean, Amanda L.; Montgomery-Downs, Hawley E.

2013-01-01

Postpartum women have highly disturbed sleep, also known as sleep fragmentation. Fragmentation extends their total sleep period, also disrupting sleep timing. A stable and earlier sleep period among non-postpartum populations are related to better performance, physical health, and mental health. However, sleep timing has not been examined among postpartum women who are also vulnerable to daytime impairment. The study objective was to examine how the timing and regularity of sleep during the early postpartum period are related to daytime functioning across postpartum weeks 2-13. In this field-based study, 71 primiparous women wore an actigraph, a small wrist-worn device that monitors sleep and sleep timing, for the 12-week study period. Mothers self-administered a 5-minute psychomotor vigilance test (PVT) each morning to evaluate the number of >500ms response lapses. They also completed a Morningness-Eveningness scale at the beginning of the study to identify chronotype. After controlling for maternal age, earlier sleep timing was associated with significantly fewer PVT lapses at postpartum weeks 9,12; a more stable sleep midpoint was associated with significantly fewer PVT lapses at postpartum weeks 2,5-13. Earlier sleep midpoints were related to more stable sleep midpoints at postpartum week 2 and a morning-type chronotype. An earlier sleep midpoint was also associated with a reduced slope of worsening PVT lapses across weeks. Across the first 12 postpartum weeks, women with earlier or more stable sleep periods had less daytime impairment than women with later or more variable sleep midpoints. Postpartum women with earlier sleep midpoints also showed less severe decrements in performance across time, which has been attributed to cumulative impacts of sleep disturbance. These data suggest the sleep period, in addition to sleep duration and fragmentation, should be more closely examined, particularly among vulnerable women, as it may affect the neurobehavioral performance of new mothers. PMID:24041725

Predicting Continuance—Findings from a Longitudinal Study of Older Adults Using an eHealth Newsletter

PubMed Central

Forquer, Heather A.; Christensen, John L.; Tan, Andy S.L.

2014-01-01

While eHealth technologies are promisingly efficient and widespread, theoretical frameworks capable of predicting long-term use, termed continuance, are lacking. Attempts to extend prominent information technology (IT) theories to the area of eHealth have been limited by small sample sizes, cross-sectional designs, self-reported as opposed to actual use measures, and a focus on technology adoption rather than continuance. To address these gaps in the literature, the present analysis includes empirical evidence of actual use of an eHealth technology over the course of one year. This large (n=4,570) longitudinal study focuses on older adults, a population with many health needs, and among whom eHealth use may be particularly important. With three measurement points over the course of a year, this study examined the effects of utilitarian and hedonic beliefs on the continued use of an eHealth newsletter using constructs from IT adoption and continuance theories. Additional analyses compared the relative strength of intentions compared to earlier use in predicting later use. Usage intention was strongly predicted by both hedonic beliefs and utilitarian beliefs. In addition, utilitarian beliefs had both direct effects on intention, as well as indirect effects, mediated by hedonic beliefs. While intention predicted subsequent use, earlier use was a significantly stronger predictor of use than intention. These findings make a theoretical contribution to an emerging literature by shedding light on the complex interplay of reasoned action and automaticity in the context of eHealth continuance. PMID:24446900

Predicting continuance-findings from a longitudinal study of older adults using an eHealth newsletter.

PubMed

Forquer, Heather A; Christensen, John L; Tan, Andy S L

2014-01-01

While eHealth technologies are promisingly efficient and widespread, theoretical frameworks capable of predicting long-term use, termed continuance, are lacking. Attempts to extend prominent information technology (IT) theories to the area of eHealth have been limited by small sample sizes, cross-sectional designs, self-reported as opposed to actual use measures, and a focus on technology adoption rather than continuance. To address these gaps in the literature, this analysis includes empirical evidence of actual use of an eHealth technology over the course of one year. This large (n = 4,570) longitudinal study focuses on older adults, a population with many health needs and among whom eHealth use may be particularly important. With three measurement points over the course of a year, this study examined the effects of utilitarian and hedonic beliefs on the continued use of an eHealth newsletter using constructs from IT adoption and continuance theories. Additional analyses compared the relative strength of intentions compared to earlier use in predicting later use. Usage intention was strongly predicted by both hedonic beliefs and utilitarian beliefs. In addition, utilitarian beliefs had both direct effects on intention and indirect effects, mediated by hedonic beliefs. While intention predicted subsequent use, earlier use was a significantly stronger predictor of use than intention. These findings make a theoretical contribution to an emerging literature by shedding light on the complex interplay of reasoned action and automaticity in the context of eHealth continuance.

Projected changes in Malawi's growing season

NASA Astrophysics Data System (ADS)

Vizy, Edward K.; Cook, Kerry H.; Chimphamba, James; McCusker, Brent

2015-09-01

Regional climate model projections at 30-km resolution are used to predict future mid-century and late-century growing season changes over Malawi due to global warming under the Representative Concentration Pathway 8.5 business-as-usual emissions forcing scenario. Three different methods for estimating growing season characteristics are applied and evaluated. All three methods yield reasonable growing season length, onset, and demise date estimates over Malawi given the wide range of uncertainty of the observations. The projections indicate the likelihood for a shorter growing season in the future over Malawi south of 13.5°S. At mid-century the growing season length is predicted to be 20-40 % (20-55 days) shorter over the southernmost districts and 5-20 % (5-30 days) shorter over the central districts. By late-century the length is predicted to be 25-55 % (20-70 days) shorter with significant differences extending into northern Malawi. The shorter growing season is primarily associated with an earlier demise date, as no significant change in the onset date is predicted. Analysis of the regional circulation and horizontal moisture flux transport indicates that the earlier demise is associated with an intensification of the thermal low over the Kalahari Desert to the south and west of Malawi and an expansion of the mid-tropospheric Kalahari anticyclone over southern Africa. The stronger thermal low/anticyclone enhances the moisture flux divergence over Malawi suppressing the convective activity at the end of the wet season.

Conformational analysis of compstatin analogues with molecular dynamics simulations in explicit water.

PubMed

Tamamis, Phanourios; Skourtis, Spiros S; Morikis, Dimitrios; Lambris, John D; Archontis, Georgios

2007-09-01

The cyclic 13-residue peptide compstatin is a potential therapeutic agent against the unregulated activation of the complement system. A thorough knowledge of its structural and dynamical properties in solution may assist the design of improved complement inhibitors. NMR studies have suggested that the 5-8 segment of free compstatin folds into a critical for activity 5-8 beta turn and the rest of the peptide is mainly disordered. Earlier computational studies of compstatin analogues with a polar-hydrogen/generalized-Born approximation reproduced the 5-8 turn, but also indicated the formation of beta-hairpin or alpha-helical elements and the existence of interactions between certain charged or aromatic sidechains. However, these features are absent or partly present in the NMR spectra, due to extensive conformational averaging. In order to check the compstatin properties with a more rigorous model of the intra- and intermolecular interactions, we conduct here 98-ns all-atom/explicit-water simulations of three compstatin analogues with variable activity; a native analogue, the more active mutant V4W/H9A and the inactive mutant Q5G. The 5-8 beta-turn population is in good accord with NMR. For the systems studied here, the simulations suggest that the 5-8 turn population does not correlate strictly with activity, in agreement with earlier mutational studies. Furthermore, they show structural differences among the analogues outside the 5-8 region. The possible role of these differences in activity is discussed. The probability of beta-hairpin or alpha-helix elements is much smaller with respect to the polar-hydrogen/GB simulations, and the persistent Trp4-Trp7 or Asp6-Arg11 sidechain interactions of the earlier GB studies are not reproduced. The present simulations extend the NMR data and improve our understanding of the properties of compstatin and related analogues.

Semantics of Inheritance and Attributions in the Description System Omega. Revision.

DTIC Science & Technology

1982-01-01

criticized either for being too general or too inflexible. General deductive procedures for predicate logic easily go out of control. There have been a...6 and 7. Section 8 is concerned with a discussion of attributions: the language is extended by introducing syntactic notations for four different...for valid formulas of the theory. The models prorided earlier are usefulL in this stage for providing a guideline and a criterion for suitability of

Clinical and Epidemiological Studies on Rickettsial Infections.

DTIC Science & Technology

1980-06-01

investigations currently or fo Tly undertaken with the collaboration or spotof the following or n’iztiona- 1) In, Ethiopia : Naval Medical Research Uit-S.. 2) In B...data from the continuing studies in Burma ocanplement and extend our earlier investigati6ns in Ethiopia , we now sumarize those results frm the Ethiopian...TESTS COMPARING RATES IN RATTUS RATTUS A14D MUS MUSCULUS WITH OTHER RODENTS (INDOORS AND OUTDOORS) IN ETHIOPIA , WITH INDICATION OP THEIR MAJOR

The Effects of Military Change of Station Moves on Spousal Earnings

DTIC Science & Technology

2016-10-01

within the literature on tied migration, military wives are an ideal “ quasi - experimental group , because such women represent perhaps the ideal typical...moves (one or two years prior to the current year) as part of the control group . Table 5.3 reports results from an extended model that also controls ...for effects of moves one or two years earlier, removing those spouse-year observations from the control group . Among spouses who ever appear in our

Observers for Systems with Nonlinearities Satisfying an Incremental Quadratic Inequality

NASA Technical Reports Server (NTRS)

Acikmese, Ahmet Behcet; Corless, Martin

2004-01-01

We consider the problem of state estimation for nonlinear time-varying systems whose nonlinearities satisfy an incremental quadratic inequality. These observer results unifies earlier results in the literature; and extend it to some additional classes of nonlinearities. Observers are presented which guarantee that the state estimation error exponentially converges to zero. Observer design involves solving linear matrix inequalities for the observer gain matrices. Results are illustrated by application to a simple model of an underwater.

Extension to Higher Mass Numbers of an Improved Knockout-Ablation-Coalescence Model for Secondary Neutron and Light Ion Production in Cosmic Ray Interactions

NASA Astrophysics Data System (ADS)

Indi Sriprisan, Sirikul; Townsend, Lawrence; Cucinotta, Francis A.; Miller, Thomas M.

Purpose: An analytical knockout-ablation-coalescence model capable of making quantitative predictions of the neutron spectra from high-energy nucleon-nucleus and nucleus-nucleus collisions is being developed for use in space radiation protection studies. The FORTRAN computer code that implements this model is called UBERNSPEC. The knockout or abrasion stage of the model is based on Glauber multiple scattering theory. The ablation part of the model uses the classical evaporation model of Weisskopf-Ewing. In earlier work, the knockout-ablation model has been extended to incorporate important coalescence effects into the formalism. Recently, alpha coalescence has been incorporated, and the ability to predict light ion spectra with the coalescence model added. The earlier versions were limited to nuclei with mass numbers less than 69. In this work, the UBERNSPEC code has been extended to make predictions of secondary neutrons and light ion production from the interactions of heavy charged particles with higher mass numbers (as large as 238). The predictions are compared with published measurements of neutron spectra and light ion energy for a variety of collision pairs. Furthermore, the predicted spectra from this work are compared with the predictions from the recently-developed heavy ion event generator incorporated in the Monte Carlo radiation transport code HETC-HEDS.

Possible impacts of climate change on natural vegetation in Saxony (Germany).

PubMed

Chmielewski, Frank M; Müller, Antje; Küchler, Wilfried

2005-11-01

Recent climate changes have had distinct impacts on plant development in many parts of the world. Higher air temperatures, mainly since the end of the 1980s, have led to advanced timing of phenological phases and consequently to an extension of the general growing season. For this reason it is interesting to know how plants will respond to future climate change. In this study simple phenological models have been developed to estimate the impact of climate change on the natural vegetation in Saxony. The estimations are based on a regional climate scenario for the state of Saxony. The results indicate that changes in the timing of phenophases could continue in the future. Due to distinct temperature changes in winter and in summer, mainly the spring and summer phases will be advanced. Spring phenophases, such as leafing or flowering, show the strongest trends. Depending on the species, the average timing of these phenophases could be advanced by 3-27 days by 2050. Phenophases in autumn show relatively small changes. Thus, the annual growth period of individual trees will be further extended, mainly because of the shift of spring phases. Frequent droughts in summer and in autumn can compensate for the earlier leafing of trees, because in this case leaf colouring and leaf fall would start some weeks earlier. In such cases, the growing period would not be really extended, but shifted to the beginning of the year.

Investigating young children's learning of mass measurement

NASA Astrophysics Data System (ADS)

Cheeseman, Jill; McDonough, Andrea; Ferguson, Sarah

2014-06-01

This paper reports results of a design experiment regarding young children's concepts of mass measurement. The research built on an earlier study in which a framework of "growth points" in early mathematics learning and a related, task-based, one-to-one interview to assess children's understanding of the measurement of mass were developed. Prompted by the results and recommendations from the earlier study, five lessons were developed that offered rich learning experiences regarding concepts of mass. The 119 Year 1 and 2 children participating in the study were interviewed using the same protocol before and after the teaching period. The assessment data showed that the majority of these children moved from using nonstandard units to using standard units and instruments for measuring mass. The findings from this study challenge the traditional approach of using informal units for an extended period before the introduction of standard units.

Prompt ionization in the CRIT II barium releases. [Critical Ionization Tests

NASA Technical Reports Server (NTRS)

Torbert, R. B.; Kletzing, C. A.; Liou, K.; Rau, D.

1992-01-01

Observations of electron and ion distributions inside a fast neutral barium jet in the ionosphere show significant fluxes within 4 km of release, presumably related to beam plasma instability processes involved in the Critical Ionization Velocity (CIV) effect. Electron fluxes exceeding 5 x 10 exp 12/sq cm-str-sec-keV were responsible for ionizing both the streaming barium and ambient oxygen. Resulting ion fluxes seem to be consistent with 1-2 percent ionization of the fast barium, as reported by optical observations, although the extended spatial distribution of the optically observed ions is difficult to reconcile with the in situ observations. When the perpendicular velocity of the neutrals falls below critical values, these processes shut off. Although these observations resemble the earlier Porcupine experimental results (Haerendel, 1982), theoretical understanding of the differences between these data and that of earlier negative experiments is still lacking.

International Geomagnetic Reference Field: the third generation.

USGS Publications Warehouse

Peddie, N.W.

1982-01-01

In August 1981 the International Association of Geomagnetism and Aeronomy revised the International Geomagnetic Reference Field (IGRF). It is the second revision since the inception of the IGRF in 1968. The revision extends the earlier series of IGRF models from 1980 to 1985, introduces a new series of definitive models for 1965-1976, and defines a provisional reference field for 1975- 1980. The revision consists of: 1) a model of the main geomagnetic field at 1980.0, not continuous with the earlier series of IGRF models together with a forecast model of the secular variation of the main field during 1980-1985; 2) definitive models of the main field at 1965.0, 1970.0, and 1975.0, with linear interpolation of the model coefficients specified for intervening dates; and 3) a provisional reference field for 1975-1980, defined as the linear interpolation of the 1975 and 1980 main-field models.-from Author

The history of Antarctic Peninsula glaciation

USGS Publications Warehouse

Barker, Peter F.

2007-01-01

As Co-Chief Scientist on DSDP Leg 35 in 1974, Cam Craddock (1930-2006) produced the first useful information on Cenozoic Antarctic Peninsula glaciation - an early middle Miocene (15-17 Ma) apparent glacial onset. Subsequent work, onshore and offshore, has greatly extended our knowledge but that early conclusion stands today. Cenozoic Antarctic Peninsula palaeoclimate as presently known is broadly consistent with global palaeoclimate proxies. Initial glacial onset was within the Eocene-Oligocene boundary interval (although earlier, short-lived glaciations have been proposed, from indirect measurements) and the peninsula probably became deglaciated in the earliest Miocene (ca. 24 Ma). The renewed middle Miocene glaciation probably continued to the present and, for the last 9 Myr at least, has persisted through glacial (orbital) cycles, with grounded ice advance to the shelf edge during maxima. Although orbital cyclicity affected earlier AP palaeoclimate also, the level of glaciation through a complete cycle is uncertain.

Noniterative computation of infimum in H(infinity) optimisation for plants with invariant zeros on the j(omega)-axis

NASA Technical Reports Server (NTRS)

Chen, B. M.; Saber, A.

1993-01-01

A simple and noniterative procedure for the computation of the exact value of the infimum in the singular H(infinity)-optimization problem is presented, as a continuation of our earlier work. Our problem formulation is general and we do not place any restrictions in the finite and infinite zero structures of the system, and the direct feedthrough terms between the control input and the controlled output variables and between the disturbance input and the measurement output variables. Our method is applicable to a class of singular H(infinity)-optimization problems for which the transfer functions from the control input to the controlled output and from the disturbance input to the measurement output satisfy certain geometric conditions. In particular, the paper extends the result of earlier work by allowing these two transfer functions to have invariant zeros on the j(omega) axis.

Design and initial application of the extended aircraft interrogation and display system: Multiprocessing ground support equipment for digital flight systems

NASA Technical Reports Server (NTRS)

Glover, Richard D.

1987-01-01

A pipelined, multiprocessor, general-purpose ground support equipment for digital flight systems has been developed and placed in service at the NASA Ames Research Center's Dryden Flight Research Facility. The design is an outgrowth of the earlier aircraft interrogation and display system (AIDS) used in support of several research projects to provide engineering-units display of internal control system parameters during development and qualification testing activities. The new system, incorporating multiple 16-bit processors, is called extended AIDS (XAIDS) and is now supporting the X-29A forward-swept-wing aircraft project. This report describes the design and mechanization of XAIDS and shows the steps whereby a typical user may take advantage of its high throughput and flexible features.

Development of advanced fuel cell system

NASA Technical Reports Server (NTRS)

Gitlow, B.; Meyer, A. P.; Bell, W. F.; Martin, R. E.

1978-01-01

An experimental program was conducted continuing the development effort to improve the weight, life, and performance characteristics of hydrogen-oxygen alkaline fuel cells for advanced power systems. These advanced technology cells operate with passive water removal which contributes to a lower system weight and extended operating life. Endurance evaluation of two single cells and two, two-cell plaques was continued. Three new test articles were fabricated and tested. A single cell completed 7038 hours of endurance testing. This cell incorporated a Fybex matrix, hybrid-frame, PPF anode, and a 90 Au/10 Pt cathode. This configuration was developed to extend cell life. Two cell plaques with dedicated flow fields and manifolds for all fluids did not exhibit the cell-to-cell electrolyte transfer that limited the operating life of earlier multicell plaques.

Noncompound nucleus decay contribution in the 12C+93Nb reaction using various formulations of nuclear proximity potential

NASA Astrophysics Data System (ADS)

Chopra, Sahila; Kaur, Arshdeep; Gupta, Raj K.

2015-01-01

The earlier study of excitation functions of *105Ag, formed in the 12C+93Nb reaction, based on the dynamical cluster-decay model (DCM), using the pocket formula for nuclear proximity potential is extended to the use of other nuclear interaction potentials derived from the Skyrme energy density functional (SEDF) based on the semiclassical extended Thomas Fermi (ETF) approach and to the use of the extended-Wong model of Gupta and collaborators. The Skyrme forces used are the old SIII and SIV and the new SSk, GSkI, and KDE0(v1) given for both normal and isospin-rich nuclei, with densities added in the frozen-density approximation. Taking advantage of the fact that different Skyrme forces provide different barrier characteristics, we look for the "barrier modification" effects in terms of choosing an appropriate force and hence for the existence or nonexistence of noncompound nucleus (nCN) effects in this reaction. Interestingly, independent of the choice of Skyrme or proximity force, the extended-Wong model fits the experimental data nicely, without any barrier modification and hence no nCN component in the measured fusion cross section, which consists of light-particle evaporation residue (ER) and intermediate-mass fragments (IMFs) up to mass 13, i.e., σfusionExpt .=σER+σIMFs . However, the predicted fusion cross section due to the extended-Wong model is much larger, possibly because of the so-far missing fusion-fission (ff) component in the data. On the other hand, in agreement with the earlier work using the pocket proximity potential, the DCM fits only some data (mainly IMFs) for only some Skyrme forces, and hence it presents the chosen reaction as a case of a large nCN component, whose empirically estimated content is fitted for use of the DCM with a fragment preformation factor taken equal to one, i.e., using DCM (P0=1 ), by introducing "barrier modification" through changing the neck-length parameter Δ R for a best fit to the empirical nCN data in each (ER and IMF) decay channel. Also, the ff component of the DCM is predicted to lie around the symmetric mass A /2 ±16 . All calculations are made for deformed and oriented coplanar nuclei.

The association between cannabis use and earlier age at onset of schizophrenia and other psychoses: meta-analysis of possible confounding factors.

PubMed

Myles, Nicholas; Newall, Hannah; Nielssen, Olav; Large, Matthew

2012-01-01

A recent meta-analysis showed that the mean age of onset of psychosis among cannabis users was almost three years earlier than that of non-cannabis users. However, because cannabis users usually smoke tobacco, the use of tobacco might independently contribute to the earlier onset of psychosis. We aimed to use meta-analysis to compare the extent to which cannabis and tobacco use are each associated with an earlier age at onset of schizophrenia and other psychoses. We also examined other factors that might have contributed to the finding of an earlier age of onset among cannabis users, including the proportion of males in the samples, the diagnostic inclusion criteria and aspects of study quality. The electronic databases MEDLINE, EMBASE, PsycINFO and ISI Web of Science, were searched for English-language peer-reviewed publications that reported age at onset of schizophrenia and other psychoses separately for cannabis users and non-users, or for tobaccosmokers and non-smokers. Meta-analysis showed that the age at onset of psychosis for cannabis users was 32 months earlier than for cannabis non-users (SMD=- 0.399, 95%CI -0.493 - -0.306, z=-8.34, p < 0.001), and was two weeks later in tobacco smokers compared with non-smokers (SMD=0.002, 95%CI -0.094 - 0.097, z=0.03, p=0.974). The main results were not affected by subgroup analyses examining studies of a single sex, the methods for making psychiatric diagnoses and measures of study quality. The results suggest that the association between cannabis use and earlier onset of psychosis is robust and is not the result either of tobacco smoking by cannabis using patients or the other potentially confounding factors we examined. This supports the hypothesis that, in some patients, cannabis use plays a causal role in the development of schizophrenia and raises the possibility of treating schizophrenia with new pharmacological treatments that have an affinity for endo-cannabinoid receptors.

Gamma-Ray Observations Related to the Acceleration of Ions in the Corona

NASA Astrophysics Data System (ADS)

Share, G. H.; Murphy, R. J.; Tolbert, A. K.; White, S. M.; Dennis, B. R.; Schwartz, R. A.; Tylka, A. J.

2016-12-01

High-energy gamma-rays associated with solar flares have been observed for over thirty-five years by various satellite experiments. The most sensitive observations have been made recently by the Large Area Telescope (LAT) experiment on the Fermi satellite. These observations confirm the earlier observations in which >100 MeV emission was detected coincident with the impulsive flare hard X-rays and also in the minutes and hours afterward. Spectral evidence from the largest of these latter, time-extended events, indicate they arise from the decay of neutral and charged pions produced by the interaction of protons and alpha particles with energies >300 MeV/nucl and >200 MeV/nucl, respectively. These high-energy time-extended events, are almost always associated with fast CME's and appear to begin from as short as 1 min to as long as 100 min after the onset of the CME. The events appear to last as short as 10 min to as long as 18 hr. Our analysis indicates that the number of >500 MeV protons producing the time-extended emission typically is an order magnitude larger than the number producing emission during the impulsive flare. The observed delays from the CME and energetic comparisons suggest that most of the energy in the ions producing the sustained time-extended emission came from a source other than the impulsive flare. It is likely that the particles were accelerated by shocks associated with the CME's and thus may have an origin common with SEPs observed in space. Our comparisons using GOES HEPAD and neutron monitor data, and those reported in this Session by DeNolfo et al. using data from PAMELA, suggest that the numbers of particles producing the gamma-ray emission are typically at least an order of magnitude smaller than those observed in space. We focus our discussion in this talk on the time-extended gamma-ray events that begin within minutes of the CME onset as they may reflect shock-acceleration of protons to hundreds of MeV deep in the corona. This work was supported by the SHINE/NSF, NASA Fermi GI and SR&T, Chief of Naval Research, and EU HESPERIA programs.

Earliest Recollections of Childhood: A Demographic Analysis.

ERIC Educational Resources Information Center

Mullen, Mary K.

1994-01-01

Four questionnaires examined the association of demographic factors with recollection for 768 adults. Found that the age of earliest memory increased across birth order, was slightly earlier for females than for males, and was earlier for Caucasians than for Asians. (Author/BC)

Variations in snow cover seasonality across the Kyrgyz Republic from 2000 to 2016 revealed through MODIS Terra and Aqua snow products

NASA Astrophysics Data System (ADS)

Tomaszewska, M. A.; Henebry, G. M.

2017-12-01

The vertical transhumance practiced by herders in the highlands of Kyrgyzstan is vulnerable to environmental change. Herd movements and pasture conditions are both affected by spatial and temporal variations in snow cover and the timing of snowmelt. Early growing season soil moisture conditions affect the phenology and growth of vegetation, especially in the high elevation pastures used for summer forage. To evaluate snow seasonality, we examined three snow cover variables—the first day of snow (FDoS), the last day of snow (LDoS), and the duration of snow cover (DoSC) over 17 years based on 8-day snow product from MODIS Terra and Aqua (MOD/MYD10A2) across the Kyrgyz Republic (KYR). To track the "snow season" efficiently in the presence of snow-capped peaks, we start each snow season at day of year (DOY) 169, approximately the summer solstice, and extend to DOY 168 of the following year. To track the interannual variation of these variables, we applied two nonparametric statistics: the Mann-Kendall trend test and the Theil-Sen linear trend estimator. Our preliminary results focusing on four rayons in two oblasts indicate both large swaths of positive and negative significant trends over the different regions of the country. Positive trends in FDoS, meaning later snow arrival, were detected in parts of central KYR. Negative trends in FDoS meaning earlier arrival were detected at lower elevations in southwestern KYR. Earlier snowmelt (negative trend in LDoS) in eastern KYR resulted in a shorter snow season (negative trend in DoSC); in contrast, later snowmelt in southwestern KYR (positive trend in LDoS) resulted in a longer period of snow cover (positive trend of DoSC). We extend the analysis to the entire country and explore the influence of terrain attribites (elevation, slope, and aspect) and MODIS IGBP land cover type (MCD12Q1) on trends in snow cover seasonality. Additionally, we ran the trend tests for the Terra and Aqua snow products separately to evaluate the effect of overpass time on snow cover retrieval.

Meterwavelength Single-pulse Polarimetric Emission Survey. III. The Phenomenon of Nulling in Pulsars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basu, Rahul; Mitra, Dipanjan; Melikidze, George I., E-mail: rahulbasu.astro@gmail.com

A detailed analysis of nulling was conducted for the pulsars studied in the Meterwavelength Single-pulse Polarimetric Emission Survey. We characterized nulling in 36 pulsars including 17 pulsars where the phenomenon was reported for the first time. The most dominant nulls lasted for a short duration, less than five periods. Longer duration nulls extending to hundreds of periods were also seen in some cases. A careful analysis showed the presence of periodicities in the transition from the null to the burst states in 11 pulsars. In our earlier work, fluctuation spectrum analysis showed multiple periodicities in 6 of these 11 pulsars.more » We demonstrate that the longer periodicity in each case was associated with nulling. The shorter periodicities usually originate from subpulse drifting. The nulling periodicities were more aligned with the periodic amplitude modulation, indicating a possible common origin for both. The most prevalent nulls last for a single period and can be potentially explained using random variations affecting the plasma processes in the pulsar magnetosphere. On the other hand, longer-duration nulls require changes in the pair-production processes, which need an external triggering mechanism for the changes. The presence of periodic nulling puts an added constraint on the triggering mechanism, which also needs to be periodic.« less

SLEPR: A Sample-Level Enrichment-Based Pathway Ranking Method — Seeking Biological Themes through Pathway-Level Consistency

PubMed Central

Yi, Ming; Stephens, Robert M.

2008-01-01

Analysis of microarray and other high throughput data often involves identification of genes consistently up or down-regulated across samples as the first step in extraction of biological meaning. This gene-level paradigm can be limited as a result of valid sample fluctuations and biological complexities. In this report, we describe a novel method, SLEPR, which eliminates this limitation by relying on pathway-level consistencies. Our method first selects the sample-level differentiated genes from each individual sample, capturing genes missed by other analysis methods, ascertains the enrichment levels of associated pathways from each of those lists, and then ranks annotated pathways based on the consistency of enrichment levels of individual samples from both sample classes. As a proof of concept, we have used this method to analyze three public microarray datasets with a direct comparison with the GSEA method, one of the most popular pathway-level analysis methods in the field. We found that our method was able to reproduce the earlier observations with significant improvements in depth of coverage for validated or expected biological themes, but also produced additional insights that make biological sense. This new method extends existing analyses approaches and facilitates integration of different types of HTP data. PMID:18818771

Application of ply level analysis to flexural wave propagation

NASA Astrophysics Data System (ADS)

Valisetty, R. R.; Rehfield, L. W.

1988-10-01

A brief survey is presented of the shear deformation theories of laminated plates. It indicates that there are certain non-classical influences that affect bending-related behavior in the same way as do the transverse shear stresses. They include bending- and stretching-related section warping and the concomitant non-classical surface parallel stress contributions and the transverse normal stress. A bending theory gives significantly improved performance if these non-classical affects are incorporated. The heterogeneous shear deformations that are characteristic of laminates with highly dissimilar materials, however, require that attention be paid to the modeling of local rotations. In this paper, it is shown that a ply level analysis can be used to model such disparate shear deformations. Here, equilibrium of each layer is analyzed separately. Earlier applications of this analysis include free-edge laminate stresses. It is now extended to the study of flexural wave propagation in laminates. A recently developed homogeneous plate theory is used as a ply level model. Due consideration is given to the non-classical influences and no shear correction factors are introduced extraneously in this theory. The results for the lowest flexural mode of travelling planar harmonic waves indicate that this approach is competitive and yields better results for certain laminates.

Stabilizing effect of resistivity towards ELM-free H-mode discharge in lithium-conditioned NSTX

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banerjee, Debabrata; Zhu, Ping; Maingi, Rajesh

Linear stability analysis of the national spherical torus experiment (NSTX) Li-conditioned ELM-free H-mode equilibria is carried out in the context of the extended magneto-hydrodynamic (MHD) model in NIMROD. Our purpose is to investigate the physical cause behind edge localized mode (ELM) suppression in experiment after the Li-coating of the divertor and the first wall of the NSTX tokamak. Besides ideal MHD modeling, including finite-Larmor radius effect and two-fluid Hall and electron diamagnetic drift contributions, a non-ideal resistivity model is employed, taking into account the increase of Z eff after Li-conditioning in ELM-free H-mode. And unlike an earlier conclusion from anmore » eigenvalue code analysis of these equilibria, NIMROD results find that after reduced recycling from divertor plates, profile modification is necessary but insufficient to explain the mechanism behind complete ELMs suppression in ideal two-fluid MHD. After considering the higher plasma resistivity due to higher Z eff, the complete stabilization could be explained. Furthermore, a thorough analysis of both pre-lithium ELMy and with-lithium ELM-free cases using ideal and non-ideal MHD models is presented, after accurately including a vacuum-like cold halo region in NIMROD to investigate ELMs.« less

Integrated cosmological probes: concordance quantified

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nicola, Andrina; Amara, Adam; Refregier, Alexandre, E-mail: andrina.nicola@phys.ethz.ch, E-mail: adam.amara@phys.ethz.ch, E-mail: alexandre.refregier@phys.ethz.ch

2017-10-01

Assessing the consistency of parameter constraints derived from different cosmological probes is an important way to test the validity of the underlying cosmological model. In an earlier work [1], we computed constraints on cosmological parameters for ΛCDM from an integrated analysis of CMB temperature anisotropies and CMB lensing from Planck, galaxy clustering and weak lensing from SDSS, weak lensing from DES SV as well as Type Ia supernovae and Hubble parameter measurements. In this work, we extend this analysis and quantify the concordance between the derived constraints and those derived by the Planck Collaboration as well as WMAP9, SPT andmore » ACT. As a measure for consistency, we use the Surprise statistic [2], which is based on the relative entropy. In the framework of a flat ΛCDM cosmological model, we find all data sets to be consistent with one another at a level of less than 1σ. We highlight that the relative entropy is sensitive to inconsistencies in the models that are used in different parts of the analysis. In particular, inconsistent assumptions for the neutrino mass break its invariance on the parameter choice. When consistent model assumptions are used, the data sets considered in this work all agree with each other and ΛCDM, without evidence for tensions.« less

Stabilizing effect of resistivity towards ELM-free H-mode discharge in lithium-conditioned NSTX

DOE PAGES

Banerjee, Debabrata; Zhu, Ping; Maingi, Rajesh

2017-05-12

Linear stability analysis of the national spherical torus experiment (NSTX) Li-conditioned ELM-free H-mode equilibria is carried out in the context of the extended magneto-hydrodynamic (MHD) model in NIMROD. Our purpose is to investigate the physical cause behind edge localized mode (ELM) suppression in experiment after the Li-coating of the divertor and the first wall of the NSTX tokamak. Besides ideal MHD modeling, including finite-Larmor radius effect and two-fluid Hall and electron diamagnetic drift contributions, a non-ideal resistivity model is employed, taking into account the increase of Z eff after Li-conditioning in ELM-free H-mode. And unlike an earlier conclusion from anmore » eigenvalue code analysis of these equilibria, NIMROD results find that after reduced recycling from divertor plates, profile modification is necessary but insufficient to explain the mechanism behind complete ELMs suppression in ideal two-fluid MHD. After considering the higher plasma resistivity due to higher Z eff, the complete stabilization could be explained. Furthermore, a thorough analysis of both pre-lithium ELMy and with-lithium ELM-free cases using ideal and non-ideal MHD models is presented, after accurately including a vacuum-like cold halo region in NIMROD to investigate ELMs.« less

First report on the safety and efficacy of an extended half-life glycoPEGylated recombinant FVIII for major surgery in severe haemophilia A.

PubMed

Hampton, K; Chowdary, P; Dunkley, S; Ehrenforth, S; Jacobsen, L; Neff, A; Santagostino, E; Sathar, J; Takedani, H; Takemoto, C M; Négrier, C

2017-09-01

N8-GP (turoctocog alfa pegol) is an extended half-life glycoPEGylated recombinant factor VIII (FVIII) product developed for the prevention and treatment of bleeds in haemophilia A patients. This is a planned interim analysis of pathfinder™3, an international, open-label, Phase 3 trial evaluating the efficacy and safety (including immunogenicity) of N8-GP administered before, during and after major surgery in severe haemophilia A patients aged ≥12 years. Sixteen patients who underwent 18 major surgical procedures (including synovectomy, joint replacement and ankle arthrodesis) were included here. Postoperative assessments were conducted daily for days 1-6, and once for days 7-14. Primary endpoint was N8-GP haemostatic efficacy, assessed after completion of surgery using a four-point scale ('excellent', 'good', 'moderate', 'none'). Haemostasis was successful (rated 'excellent' or 'good') on completion of surgery in 17 (94.4%) procedures and rated as 'moderate' (5.6%) for one surgery in a patient with multiple comorbidities who needed an intraoperative N8-GP dose (20.7 IU kg -1 ). In the postoperative period, three bleeds occurred (one during days 1-6; two during days 7-14); all were successfully treated with N8-GP. Mean N8-GP consumption on day of surgery was 80.0 IU kg -1 ; patients received a mean of 1.7 doses (median: 2, range: 1-3). No safety concerns were identified. The data showed that N8-GP was effective and well tolerated for the prevention and treatment of bleeds during major surgery; such FVIII products with extended half-lives may modify current treatment schedules, enabling fewer infusions and earlier patient discharge. © 2017 John Wiley & Sons Ltd.

Training physician-scientists: a model for integrating research into psychiatric residency.

PubMed

Back, Sudie E; Book, Sarah W; Santos, Alberto B; Brady, Kathleen T

2011-01-01

the number of physicians engaged in research careers has declined significantly over the past two decades. Physicians with in-depth experience and formal training in research design, development, implementation, statistical analysis, and interpretation of scientific information are rare. in response to this shortage, the Medical University of South Carolina (MUSC) launched an NIH-funded research track in 2006 to address the institutional, financial, and regulatory barriers to research training during residency. The primary aim was to incorporate a research track within a 4-year psychiatric residency program for physicians. A secondary goal was to extend recruitment into earlier phases of medical training by offering summer research fellowships to medical and undergraduate students. this article describes the program including core mechanisms of training, recruitment, and outcomes to date. the program provides a model to effectively integrate research training during residency without increasing the number of years of residency training. The training components described herein should be exportable to other psychiatric residency training programs and potentially other specialties of medicine.

Cirrhosis mortality among former American prisoners of war of World War II and the Korean conflict: results of a 50-year follow-up.

PubMed

Page, W F; Miller, R N

2000-10-01

In our earlier, 30-year follow-up of American prisoners of war (POWs) of World War II and the Korean conflict, we found evidence of increased cirrhosis mortality. Using federal records, we have now extended our follow-up to 50 years (42 years for Korean conflict veterans) and have used proportional hazards analysis to compare the mortality experience of POWs with that of controls. Compared with their controls, World War II POWs had a 32% higher risk of cirrhosis mortality (statistically significant), and mortality risk was higher in the first 30 years of follow-up and also among those aged 51 years and older. Korean POWs had roughly the same risk of cirrhosis mortality as their controls. Neither self-reported data on alcohol consumption nor supplemental morbidity data satisfactorily explained the differences in risk between POWs and controls, although there was evidence that POWs tended to have higher rates of hepatitis, helminthiasis, and nutritional deprivation.

Transport of Space Environment Electrons: A Simplified Rapid-Analysis Computational Procedure

NASA Technical Reports Server (NTRS)

Nealy, John E.; Anderson, Brooke M.; Cucinotta, Francis A.; Wilson, John W.; Katz, Robert; Chang, C. K.

2002-01-01

A computational procedure for describing transport of electrons in condensed media has been formulated for application to effects and exposures from spectral distributions typical of electrons trapped in planetary magnetic fields. The procedure is based on earlier parameterizations established from numerous electron beam experiments. New parameterizations have been derived that logically extend the domain of application to low molecular weight (high hydrogen content) materials and higher energies (approximately 50 MeV). The production and transport of high energy photons (bremsstrahlung) generated in the electron transport processes have also been modeled using tabulated values of photon production cross sections. A primary purpose for developing the procedure has been to provide a means for rapidly performing numerous repetitive calculations essential for electron radiation exposure assessments for complex space structures. Several favorable comparisons have been made with previous calculations for typical space environment spectra, which have indicated that accuracy has not been substantially compromised at the expense of computational speed.

Structural insights into the intertwined dimer of fyn SH2.

PubMed

Huculeci, Radu; Garcia-Pino, Abel; Buts, Lieven; Lenaerts, Tom; van Nuland, Nico

2015-12-01

Src homology 2 domains are interaction modules dedicated to the recognition of phosphotyrosine sites incorporated in numerous proteins found in intracellular signaling pathways. Here we provide for the first time structural insight into the dimerization of Fyn SH2 both in solution and in crystalline conditions, providing novel crystal structures of both the dimer and peptide-bound structures of Fyn SH2. Using nuclear magnetic resonance chemical shift analysis, we show how the peptide is able to eradicate the dimerization, leading to monomeric SH2 in its bound state. Furthermore, we show that Fyn SH2's dimer form differs from other SH2 dimers reported earlier. Interestingly, the Fyn dimer can be used to construct a completed dimer model of Fyn without any steric clashes. Together these results extend our understanding of SH2 dimerization, giving structural details, on one hand, and suggesting a possible physiological relevance of such behavior, on the other hand. © 2015 The Protein Society.

Age of the Scan Basin (Scotia Sea)

NASA Astrophysics Data System (ADS)

Schreider, Al. A.; Schreider, A. A.; Galindo-Zaldivar, J.; Maldonado, A.; Sazhneva, A. E.; Evsenko, E. I.

2017-03-01

Integrated geological and geophysical analysis of the anomalous magnetic field along with the previously unpublished profiles of Spanish expeditions onboard the R/V Hesperides and international databases of geomagnetic data processed in the context of the global tectonics concepts made it possible to identify paleomagnetic anomalies C11-C15 and compile the first map of the bottom geochronology of the Scan Basin. Unlike in earlier known publications, the paleoaxis of spreading does extend northeast, but approximately at an angle of 345°. According to calculations, spreading began 35.294‒35.706 Ma ago during chron C15r, and the spreading paleoaxis was abandoned 29.527‒29.970 Ma ago during chron C11n.2n. Thus, the destruction of the American-Antarctic bridge in the region joining the Bruce and Discovery banks with formation of oceanic crust in the Scan Basin started about 36 Ma ago. Regular spreading of the bottom has been continuing for about 6 Ma at a average rate close to 1.8 cm/year.

Research Investigation Directed Toward Extending the Useful Range of the Electromagnetic Spectrum.

DTIC Science & Technology

1982-03-31

A. Chandross in "The Exciplex ", M. Gordon and W. R. Ware, Ed., Academic Press, New York, 1975, p. 187. (5) K. Rotkiewicz, K. H. Grellmann, and Z. R...reaction of the end groups on the opposite sides of the chain. W_ -( 0 ) In our earlier studies (8 )’ (9 ) we determined that exciplex (excited charge...sandwich type structure. We have used picosecond laser excitation and streak camera-optical multi- channel detection of exciplex fluorescence at

DOE Office of Scientific and Technical Information (OSTI.GOV)

Macek, Joseph H; Sternberg, James; Ovchinnikov, Serguei Yurevich

Deep minima in He(e,2e)He{sup +} triply differential cross sections are traced to vortices in atomic wave functions. Such vortices have been predicted earlier, but the present calculations show that they have also been observed experimentally, although not recognized as vortices. Their observation in (e,2e) measurements shows that vortices play an important role in electron correlations related to the transfer of angular momentum between incident and ejected electrons. The vortices significantly extend the list of known features that summarize the general picture of electron correlations in impact ionization.

Effects of experimental hypogravity on peroxidase and cell wall constituents in the dwarf marigold

NASA Technical Reports Server (NTRS)

Siegel, S.; Speitel, T.; Shiraki, D.; Fukumoto, J.

1977-01-01

Dwarf marigolds grown from seed under experimental hypogravity are modified in lignin content, hemicellulose composition and peroxidase activity. The two conditions used, clinostats and flotation, induced changes differing in magnitude but qualitatively similar. Most responses on clinostats required correction for vertical axis rotational effects, thus limiting the value of these instruments in free-fall simulation. These findings extend earlier observations suggesting that increased peroxidase and decreased lignin are characteristic of growth under experimental hypogravity.

Effects of experimental hypogravity on peroxidase and cell wall constituents in the dwarf marigold

NASA Technical Reports Server (NTRS)

Siegel, S.; Speitel, T.; Shiraki, D.; Fukumoto, J.

1978-01-01

Dwarf Marigolds grown from seed under experimental hypogravity are modified in lignin content, hemicellulose composition, and peroxidase activity. The two conditions used, clinostats and flotation, induced changes differing in magnitude but qualitatively similar. Most responses on clinostats required corrections for vertical axis rotational effects, thus limiting the value of these instruments in free-fall simulation. These findings extend earlier observations suggesting that increased peroxidase and decreased lignin are characteristic of growth under experimental hypogravity.

CCR 20th Anniversary commentary: in search of cetuximab's first indication-combination therapy with irinotecan in colorectal cancer.

PubMed

Hicklin, Daniel J

2015-04-01

The research article by Prewett and colleagues, published in the May 1, 2002, issue of Clinical Cancer Research, provided important translational data that extended earlier preclinical and clinical studies with the human-murine chimeric anti-EGFR monoclonal antibody C225. Subsequent clinical trials with C225 led to the demonstration of its efficacy in combination with irinotecan and regulatory approval for the treatment of metastatic colorectal cancer. ©2015 American Association for Cancer Research.

The new era of robotic neck surgery: The universal application of the retroauricular approach.

PubMed

Byeon, Hyung Kwon; Koh, Yoon Woo

2015-12-01

Recent advances in technology has triggered the introduction of surgical robotics in the field of head and neck surgery and changed the landscape indefinitely. The advent of transoral robotic surgery and robotic thyroidectomy techniques has urged the extended applications of the robot to other neck surgeries including remote access surgeries. Based on earlier reports and our surgical experiences, this review will discuss in detail various robotic head and neck surgeries via retroauricular approach. © 2015 Wiley Periodicals, Inc.

Connected, disconnected and strange quark contributions to HVP

NASA Astrophysics Data System (ADS)

Bijnens, Johan; Relefors, Johan

2016-11-01

We calculate all neutral vector two-point functions in Chiral Perturbation Theory (ChPT) to two-loop order and use these to estimate the ratio of disconnected to connected contributions as well as contributions involving the strange quark. We extend the ratio of -1/10 derived earlier in two flavour ChPT at one-loop order to a large part of the higher order contributions and discuss corrections to it. Our final estimate of the ratio disconnected to connected is negative and a few % in magnitude.

Exotic containers for capillary surfaces

NASA Technical Reports Server (NTRS)

Concus, Paul; Finn, Robert

1991-01-01

This paper discusses 'exotic' rotationally symmetric containers that admit an entire continuum of distinct equilibrium capillary free surfaces. The paper extends earlier work to a larger class of parameters and clarifies and simplifies the governing differential equations, while expressing them in a parametric form appropriate for numerical integration. A unified presentation suitable for both zero and nonzero gravity is given. Solutions for the container shapes are depicted graphically along with members of the free-surface continuum, and comments are given concerning possible physical experiments.

Extended atmospheres of outer planet satellites and comets

NASA Technical Reports Server (NTRS)

Smyth, William H.; Combi, Michael R.

1987-01-01

A major model documentation paper for cometary gas coronae and a second paper successfully applied the model to simulate the hydrogen Lyman-alpha coma of comet Kohoutek were completed and are discussed. New and very exciting data for the hydrogen distribution in the Saturn system obtained form earlier unreduced Voyager 1 and Voyager 2 data are preliminarily reviewed. This new data opens up a whole new series of investigations and indicate that Saturn's corona plays a major role in supplying hydrogen to the circumplanetary volume.

New dust opacity maps from Viking IR thermal mapper data

NASA Technical Reports Server (NTRS)

Martin, T. Z.; Richardson, M. I.

1992-01-01

Mapping of dust opacity of the Martian atmosphere, using the silicate-induced absorption of 9 micron radiation, was performed with the Viking Infrared Thermal Mapper (IRTM) data for several local dust storms and in a global sense. We present here the first results from an effort to extend the earlier mapping work to the period of the 1977b major storm, and to concentrate attention on the details of opacity behavior during the initial phases of the 1977a and b storms.

Further results on the stagnation point boundary layer with hydrogen injection.

NASA Technical Reports Server (NTRS)

Wu, P.; Libby, P. A.

1972-01-01

The results of an earlier paper on the behavior of the boundary layer at an axisymmetric stagnation with hydrogen injection into a hot external airstream are extended to span the entire range from essentially frozen to essentially equilibrium flow. This extension is made possible by the employment of finite difference methods; the accurate treatment of the boundary conditions at 'infinity,' the differencing technique employed and the formulation resulting in block tri-diagonal matrices are slight variants in the present work.

Computer-based visual communication in aphasia.

PubMed

Steele, R D; Weinrich, M; Wertz, R T; Kleczewska, M K; Carlson, G S

1989-01-01

The authors describe their recently developed Computer-aided VIsual Communication (C-VIC) system, and report results of single-subject experimental designs probing its use with five chronic, severely impaired aphasic individuals. Studies replicate earlier results obtained with a non-computerized system, demonstrate patient competence with the computer implementation, extend the system's utility, and identify promising areas of application. Results of the single-subject experimental designs clarify patients' learning, generalization, and retention patterns, and highlight areas of performance difficulties. Future directions for the project are indicated.

Trends in discharge and flow season timing of the Onyx River, Wright Valley, Antarctica since 1969

USGS Publications Warehouse

Gooseff, Michael N.; McKnight, Diane M.; Doran, Peter T.; Lyons, W. Berry

2007-01-01

/decade at Vanda), and increasing flow season lengths (by 7 d/decade at LWRT, and 2.7 d/decade at Vanda), influenced by earlier start and later end dates (5.2 and 0.8 d/decade, respectively at LWRT; 4.8, 1.4 d/decade, respectively at Vanda). This suggests that flow season climate patterns in the Dry Valleys are decreasing glacier melt intensity overall, but extending the period of meltwater generation

The Effect of Failing to Recapitalize the B-52H Defensive Avionics System on Future Operations

DTIC Science & Technology

2009-04-01

reactive jamming, compensation for wing flexing to prevent wire chaffing and ensuring the necessary degree of cooling is available to extend LRU life ...repair parts. Parts of this system including the 6-gun CRT, referenced earlier, were replaced with a commercial off-the- shelf item built by Condor...This effort will provide a small extension to the service life of the existing BWOs. There is also an effort underway to replace the BWOs with

8- to 13-μm Spectra of Saturn's A and B Rings

NASA Astrophysics Data System (ADS)

Lynch, David K.; Mazuk, Ann L.; Russell, Ray W.; Hackwell, John A.; Hanner, Martha S.

2000-07-01

Thermal IR spectroscopy of Saturn's A and B rings in the 8- to 13-μm range reveals a smooth, Planck-like continuum with no spectral structure that could be attributed to optically thin water ice or silicate dust. The brightness temperatures of the A and B rings obtained by fitting a Planck function to the spectra were 90.3±0.9 and 90.5±0.6 K, respectively, in good agreement with and extending earlier photometric measurements.

JPL Test Effectiveness Analysis

NASA Technical Reports Server (NTRS)

Shreck, Stephanie; Sharratt, Stephen; Smith, Joseph F.; Strong, Edward

2008-01-01

1) The pilot study provided meaningful conclusions that are generally consistent with the earlier Test Effectiveness work done between 1992 and 1994: a) Analysis of pre-launch problem/failure reports is consistent with earlier work. b) Analysis of post-launch early mission anomaly reports indicates that there are more software issues in newer missions, and the no-test category for identification of post-launch failures is more significant than in the earlier analysis. 2) Future work includes understanding how differences in Missions effect these analyses: a) There are large variations in the number of problem reports and issues that are documented by the different Projects/Missions. b) Some missions do not have any reported environmental test anomalies, even though environmental tests were performed. 3) Each project/mission has different standards and conventions for filling out the PFR forms, the industry may wish to address this issue: a) Existing problem reporting forms are to document and track problems, failures, and issues (etc.) for the projects, to ensure high quality. b) Existing problem reporting forms are not intended for data mining.

Counting statistics of chaotic resonances at optical frequencies: Theory and experiments

NASA Astrophysics Data System (ADS)

Lippolis, Domenico; Wang, Li; Xiao, Yun-Feng

2017-07-01

A deformed dielectric microcavity is used as an experimental platform for the analysis of the statistics of chaotic resonances, in the perspective of testing fractal Weyl laws at optical frequencies. In order to surmount the difficulties that arise from reading strongly overlapping spectra, we exploit the mixed nature of the phase space at hand, and only count the high-Q whispering-gallery modes (WGMs) directly. That enables us to draw statistical information on the more lossy chaotic resonances, coupled to the high-Q regular modes via dynamical tunneling. Three different models [classical, Random-Matrix-Theory (RMT) based, semiclassical] to interpret the experimental data are discussed. On the basis of least-squares analysis, theoretical estimates of Ehrenfest time, and independent measurements, we find that a semiclassically modified RMT-based expression best describes the experiment in all its realizations, particularly when the resonator is coupled to visible light, while RMT alone still works quite well in the infrared. In this work we reexamine and substantially extend the results of a short paper published earlier [L. Wang et al., Phys. Rev. E 93, 040201(R) (2016), 10.1103/PhysRevE.93.040201].

Dynamic texture recognition using local binary patterns with an application to facial expressions.

PubMed

Zhao, Guoying; Pietikäinen, Matti

2007-06-01

Dynamic texture (DT) is an extension of texture to the temporal domain. Description and recognition of DTs have attracted growing attention. In this paper, a novel approach for recognizing DTs is proposed and its simplifications and extensions to facial image analysis are also considered. First, the textures are modeled with volume local binary patterns (VLBP), which are an extension of the LBP operator widely used in ordinary texture analysis, combining motion and appearance. To make the approach computationally simple and easy to extend, only the co-occurrences of the local binary patterns on three orthogonal planes (LBP-TOP) are then considered. A block-based method is also proposed to deal with specific dynamic events such as facial expressions in which local information and its spatial locations should also be taken into account. In experiments with two DT databases, DynTex and Massachusetts Institute of Technology (MIT), both the VLBP and LBP-TOP clearly outperformed the earlier approaches. The proposed block-based method was evaluated with the Cohn-Kanade facial expression database with excellent results. The advantages of our approach include local processing, robustness to monotonic gray-scale changes, and simple computation.

A laboratory study of nonlinear changes in the directionality of extreme seas

NASA Astrophysics Data System (ADS)

Latheef, M.; Swan, C.; Spinneken, J.

2017-03-01

This paper concerns the description of surface water waves, specifically nonlinear changes in the directionality. Supporting calculations are provided to establish the best method of directional wave generation, the preferred method of directional analysis and the inputs on which such a method should be based. These calculations show that a random directional method, in which the phasing, amplitude and direction of propagation of individual wave components are chosen randomly, has benefits in achieving the required ergodicity. In terms of analysis procedures, the extended maximum entropy principle, with inputs based upon vector quantities, produces the best description of directionality. With laboratory data describing the water surface elevation and the two horizontal velocity components at a single point, several steep sea states are considered. The results confirm that, as the steepness of a sea state increases, the overall directionality of the sea state reduces. More importantly, it is also shown that the largest waves become less spread or more unidirectional than the sea state as a whole. This provides an important link to earlier descriptions of deterministic wave groups produced by frequency focusing, helps to explain recent field observations and has important practical implications for the design of marine structures and vessels.

Health Equity and the Fallacy of Treating Causes of Population Health as if They Sum to 100.

PubMed

Krieger, Nancy

2017-04-01

Numerous examples exist in population health of work that erroneously forces the causes of health to sum to 100%. This is surprising. Clear refutations of this error extend back 80 years. Because public health analysis, action, and allocation of resources are ill served by faulty methods, I consider why this error persists. I first review several high-profile examples, including Doll and Peto's 1981 opus on the causes of cancer and its current interpretations; a 2015 high-publicity article in Science claiming that two thirds of cancer is attributable to chance; and the influential Web site "County Health Rankings & Roadmaps: Building a Culture of Health, County by County," whose model sums causes of health to equal 100%: physical environment (10%), social and economic factors (40%), clinical care (20%), and health behaviors (30%). Critical analysis of these works and earlier historical debates reveals that underlying the error of forcing causes of health to sum to 100% is the still dominant but deeply flawed view that causation can be parsed as nature versus nurture. Better approaches exist for tallying risk and monitoring efforts to reach health equity.

Health Equity and the Fallacy of Treating Causes of Population Health as if They Sum to 100%

PubMed Central

2017-01-01

Numerous examples exist in population health of work that erroneously forces the causes of health to sum to 100%. This is surprising. Clear refutations of this error extend back 80 years. Because public health analysis, action, and allocation of resources are ill served by faulty methods, I consider why this error persists. I first review several high-profile examples, including Doll and Peto’s 1981 opus on the causes of cancer and its current interpretations; a 2015 high-publicity article in Science claiming that two thirds of cancer is attributable to chance; and the influential Web site “County Health Rankings & Roadmaps: Building a Culture of Health, County by County,” whose model sums causes of health to equal 100%: physical environment (10%), social and economic factors (40%), clinical care (20%), and health behaviors (30%). Critical analysis of these works and earlier historical debates reveals that underlying the error of forcing causes of health to sum to 100% is the still dominant but deeply flawed view that causation can be parsed as nature versus nurture. Better approaches exist for tallying risk and monitoring efforts to reach health equity. PMID:28272952

The Mineralogy of Martian Dust: Design and Analysis Considerations for an X-Ray Diffraction/X-Ray Fluorescence (XRD/XRF) Instrument for Exobiological Studies

NASA Technical Reports Server (NTRS)

Blake, David; Vaniman, David; Bish, David; Morrison, David (Technical Monitor)

1994-01-01

A principal objective of Mars exploration is the search for evidence of past life which may have existed during an earlier clement period of Mars history. We would like to investigate the history of surface water activity (which is a requirement for all known forms of life) by identifying and documenting the distribution of minerals which require water for their formation or distribution. A knowledge of the mineralogy of the present Martian surface would help to identify areas which, due to the early activity of water, might have harbored ancient life. It would be desirable to establish the presence and characterize the distribution of hydrated minerals such as clays, and of minerals which are primarily of sedimentary origin such as carbonates, silica and evaporites. Mineralogy, which is more critical to exobiological exploration than is simple chemical analysis (absent the detection of organics), will remain unknown or will at best be imprecisely constrained unless a technique sensitive to mineral structure such as powder X-ray diffraction (XRD) is employed. Additional information is contained in the original extended abstract.

Optimizing qPlus sensor assemblies for simultaneous scanning tunneling and noncontact atomic force microscopy operation based on finite element method analysis

DOE PAGES

Dagdeviren, Omur E.; Schwarz, Udo D.

2017-03-20

Quartz tuning forks that have a probe tip attached to the end of one of its prongs while the other prong is arrested to a holder (“qPlus” configuration) have gained considerable popularity in recent years for high-resolution atomic force microscopy imaging. The small size of the tuning forks and the complexity of the sensor architecture, however, often impede predictions on how variations in the execution of the individual assembly steps affect the performance of the completed sensor. Extending an earlier study that provided numerical analysis of qPlus-style setups without tips, this work quantifies the influence of tip attachment on themore » operational characteristics of the sensor. The results using finite element modeling show in particular that for setups that include a metallic tip that is connected via a separate wire to enable the simultaneous collection of local forces and tunneling currents, the exact realization of this wire connection has a major effect on sensor properties such as spring constant, quality factor, resonance frequency, and its deviation from an ideal vertical oscillation.« less

Optimizing qPlus sensor assemblies for simultaneous scanning tunneling and noncontact atomic force microscopy operation based on finite element method analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dagdeviren, Omur E.; Schwarz, Udo D.

Quartz tuning forks that have a probe tip attached to the end of one of its prongs while the other prong is arrested to a holder (“qPlus” configuration) have gained considerable popularity in recent years for high-resolution atomic force microscopy imaging. The small size of the tuning forks and the complexity of the sensor architecture, however, often impede predictions on how variations in the execution of the individual assembly steps affect the performance of the completed sensor. Extending an earlier study that provided numerical analysis of qPlus-style setups without tips, this work quantifies the influence of tip attachment on themore » operational characteristics of the sensor. The results using finite element modeling show in particular that for setups that include a metallic tip that is connected via a separate wire to enable the simultaneous collection of local forces and tunneling currents, the exact realization of this wire connection has a major effect on sensor properties such as spring constant, quality factor, resonance frequency, and its deviation from an ideal vertical oscillation.« less

A Comparative Efficacy of Low-Dose Combined Oral Contraceptives Containing Desogestrel and Drospirenone in Premenstrual Symptoms

PubMed Central

Wichianpitaya, Jirath; Taneepanichskul, Surasak

2013-01-01

Objective. To compare the efficacy of low-dose COC containing desogestrel (DSG) with drospirenone (DRSP) in the changes of premenstrual symptoms. Methods. In an open-label randomized controlled trial, 90 women with premenstrual syndrome who required COC were randomly recruited and allocated equally to receive either 6 cycles of 20 micrograms ethinyl estradiol (EE)/150 micrograms DSG (DSG group) or 20 micrograms EE/3 mg DRSP (DRSP group) in 24/4 extended regimen. Analysis of covariance and repeated analysis of variance were used to determine the difference of mean Women's Health Assessment Questionnaire (WHAQ) scores changes between groups, within group, and in premenstrual, menstrual, and postmenstrual phases. Results. Baseline characteristics and WHAQ scores were comparable. At the ends of the 3rd and the 6th cycles, mean WHAQ scores of all the 3 phases in DRSP group showed significant reduction and were significantly lower than those in DSG group. DSG group showed significant reduction in both premenstrual and menstrual phases after the 6th cycle. Adverse effects were comparable in both groups. In conclusion, low-dose COC containing either DSG or DRSP reduced premenstrual symptoms, but the latter showed greater efficacy and earlier reduction. PMID:23577032

A critical investigation of post-liquefaction strength and steady-state flow behavior of saturated soils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jong, H.L.

1988-01-01

The first objective was to perform a critical evaluation of the recently proposed steady-state analysis methodology for evaluation of post-liquefaction stability of potentially liquefiable soils. This analysis procedure is based on direct comparison between the in-situ undrained residual (steady state) strength of soils in an embankment or foundation, and the driving shear stresses in these soils. A laboratory investigation was performed to investigate factors affecting steady-state strengths, and also to evaluate the validity of assumptions involved in correcting the results of laboratory steady-state strength tests on undisturbed samples for effects of sampling disturbance in order to estimate in-situ strengths. Next,more » a field case study was performed using the steady-state analysis and testing methodologies to analyze Lower San Fernando Dam, which suffered a liquefaction-induced slope failure as a results of a 1971 earthquake. This leads to the second objective which was to extend the Lower San Fernando Dam case study to consideration of analysis methods used to evaluate the likelihood of triggering liquefaction during an earthquake. Finally, a number of the high quality undisturbed samples were subjected to undrained cyclic testing in order to repeat an earlier (1973) study of the use of cyclic tests data to predict liquefaction behavior at Lower San Fernando Dam.« less

Ethical learning on international medical electives: a case-based analysis of medical student learning experiences.

PubMed

Bowsher, Gemma; Parry-Billings, Laura; Georgeson, Anna; Baraitser, Paula

2018-04-11

Students on international medical electives face complex ethical issues when undertaking clinical work. The variety of elective destinations and the culturally specific nature of clinical ethical issues suggest that pre-elective preparation could be supplemented by in-elective support. An online, asynchronous, case-based discussion was piloted to support ethical learning on medical student electives. We developed six scenarios from elective diaries to stimulate peer-facilitated discussions during electives. We evaluated the transcripts to assess whether transformative, experiential learning took place, assessing specifically for indications that 1) critical reflection, 2) reflective action and 3) reflective learning were taking place. We also completed a qualitative thematic content analysis of the discussions. Of forty-one extended comments, nine responses showed evidence of transformative learning (Mezirow stage three). The thematic analysis identified five themes: adopting a position on ethical issues without overt analysis; presenting issues in terms of their effects on students' ability to complete tasks; describing local contexts and colleagues as "other"; difficulty navigating between individual and structural issues, and overestimation of the impact of individual action on structures and processes. Results suggest a need to: frame ethical learning on elective so that it builds on earlier ethical programmes in the curriculum, and encourages students to adopt structured approaches to complex ethical issues including cross-cultural negotiation and to enhance global health training within the curriculum.

Whole-rock analyses of core samples from the 1988 drilling of Kilauea Iki lava lake, Hawaii

USGS Publications Warehouse

Helz, Rosalind Tuthill; Taggart, Joseph E.

2010-01-01

This report presents and evaluates 64 major-element analyses of previously unanalyzed Kilauea Iki drill core, plus three samples from the 1959 and 1960 eruptions of Kilauea, obtained by X-ray fluorescence (XRF) analysis during the period 1992 to 1995. All earlier major-element analyses of Kilauea Iki core, obtained by classical (gravimetric) analysis, were reported and evaluated in Helz and others (1994). In order to assess how well the newer data compare with this earlier suite of analyses, a subset of 24 samples, which had been analyzed by classical analysis, was reanalyzed using the XRF technique; those results are presented and evaluated in this report also. The XRF analyses have not been published previously. This report also provides an overview of how the chemical variations observed in these new data fit in with the chemical zonation patterns and petrologic processes inferred in earlier studies of Kilauea Iki.

Empirical support for global integrated assessment modeling: Productivity trends and technological change in developing countries' agriculture and electric power sectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sathaye, Jayant A.

2000-04-01

Integrated assessment (IA) modeling of climate policy is increasingly global in nature, with models incorporating regional disaggregation. The existing empirical basis for IA modeling, however, largely arises from research on industrialized economies. Given the growing importance of developing countries in determining long-term global energy and carbon emissions trends, filling this gap with improved statistical information on developing countries' energy and carbon-emissions characteristics is an important priority for enhancing IA modeling. Earlier research at LBNL on this topic has focused on assembling and analyzing statistical data on productivity trends and technological change in the energy-intensive manufacturing sectors of five developing countries,more » India, Brazil, Mexico, Indonesia, and South Korea. The proposed work will extend this analysis to the agriculture and electric power sectors in India, South Korea, and two other developing countries. They will also examine the impact of alternative model specifications on estimates of productivity growth and technological change for each of the three sectors, and estimate the contribution of various capital inputs--imported vs. indigenous, rigid vs. malleable-- in contributing to productivity growth and technological change. The project has already produced a data resource on the manufacturing sector which is being shared with IA modelers. This will be extended to the agriculture and electric power sectors, which would also be made accessible to IA modeling groups seeking to enhance the empirical descriptions of developing country characteristics. The project will entail basic statistical and econometric analysis of productivity and energy trends in these developing country sectors, with parameter estimates also made available to modeling groups. The parameter estimates will be developed using alternative model specifications that could be directly utilized by the existing IAMs for the manufacturing, agriculture, and electric power sectors.« less

Characteristic functions of quantum heat with baths at different temperatures

NASA Astrophysics Data System (ADS)

Aurell, Erik

2018-06-01

This paper is about quantum heat defined as the change in energy of a bath during a process. The presentation takes into account recent developments in classical strong-coupling thermodynamics and addresses a version of quantum heat that satisfies quantum-classical correspondence. The characteristic function and the full counting statistics of quantum heat are shown to be formally similar. The paper further shows that the method can be extended to more than one bath, e.g., two baths at different temperatures, which opens up the prospect of studying correlations and heat flow. The paper extends earlier results on the expected quantum heat in the setting of one bath [E. Aurell and R. Eichhorn, New J. Phys. 17, 065007 (2015), 10.1088/1367-2630/17/6/065007; E. Aurell, Entropy 19, 595 (2017), 10.3390/e19110595].

T-Duality in an H-Flux: Exchange of Momentum and Winding

NASA Astrophysics Data System (ADS)

Han, Fei; Mathai, Varghese

2018-02-01

Using our earlier proposal for Ramond-Ramond fields in an H-flux on loop space (Han et al. in Commun Math Phys 337(1):127-150, 2015. arXiv:1405.1320), we extend the Hori isomorphism in Bouwknegt et al. (Commun Math Phys 249:383-415, 2004. arXiv:hep-th/0306062; Phys Rev Lett 92:181601, 2004. arXiv:hep-th/0312052) from invariant differential forms, to invariant exotic differential forms such that the momentum and winding numbers are exchanged, filling in a gap in the literature. We also extend the compatibility of the action of invariant exact Courant algebroids on the T-duality isomorphism in Cavalcanti and Gualtieri (in: CRM proceedings of lecture notes, vol 50, pp 341-365, American Mathematical Society, Providence, 2010 ), to the T-duality isomorphism on exotic invariant differential forms.

Premorbid Risk Factors for Major Depressive Disorder: Are They Associated With Early Onset and Recurrent Course?

PubMed Central

Wilson, Sylia; Vaidyanathan, Uma; Miller, Michael B.; McGue, Matt; Iacono, William G.

2014-01-01

Premorbid risk for major depressive disorder (MDD) and predictors of an earlier onset and recurrent course were examined in two studies in a large, community-based sample of parents and offspring, prospectively assessed from late childhood into adulthood. In Study 1 (N = 2,764 offspring and their parents), parental psychiatric status, offspring personality at age 11, and age-11 offspring internalizing and externalizing symptoms predicted the subsequent development of MDD, as did poor quality parent-child relationships, poor academic functioning, early pubertal development, and childhood maltreatment by age 11. Parental MDD and adult antisocial behavior, offspring negative emotionality and disconstraint, externalizing symptoms, and childhood maltreatment predicted an earlier onset of MDD, after accounting for course; lower positive emotionality, trait anxiety, and childhood maltreatment predicted recurrent MDD, after accounting for age of onset. In Study 2 (N = 7,146), we examined molecular genetic risk for MDD by extending recent reports of associations with glutamatergic system genes. We failed to confirm associations with MDD using either individual SNP-based tests or gene-based analyses. Overall, results speak to the pervasiveness of risk for MDD, as well as specific risk for early-onset MDD; risk for recurrent MDD appears to be largely a function of its often earlier onset. PMID:25422974

Facilitation of extinction and re-extinction of operant behavior in mice by chlordiazepoxide and D-cycloserine.

PubMed

Leslie, Julian C; Norwood, Kelly

2013-05-01

The aim was to compare operant extinction with re-extinction following re-acquisition and to investigate neuropharmacological mechanisms through administration of drugs potentiating GABAergic or glutamatergic systems. Groups of C57Bl/6 mice were trained to lever press for food on a fixed ratio schedule, then extinguished with or without pre-session chlordiazepoxide or post-session d-cycloserine administration (15mg/kg in each case), then retrained to lever press for food, then re-extinguished with or without pre-session chlordiazepoxide or post-session d-cycloserine. Under vehicle injections, extinction and re-extinction curves were indistinguishable, but drug treatments showed that there was less resistance to extinction in the re-extinction phase. Chlordiazepoxide facilitated extinction and re-extinction, with an earlier effect during re-extinction. d-Cycloserine also facilitated extinction and re-extinction, with some evidence of an earlier effect during re-extinction. These results replicate and extend earlier findings with operant extinction, but differ from some previous reports of d-cycloserine on re-extinction of Pavlovian conditioned fear. Implications for accounts of the similarities and differences between neural mechanisms of extinction following either Pavlovian or operant conditioning, and applications of these findings, are discussed. Copyright © 2013 Elsevier Inc. All rights reserved.

Spring plant phenology and false springs in the conterminous US during the 21st century

USGS Publications Warehouse

Allstadt, Andrew J.; Vavrus, Stephen J.; Heglund, Patricia J.; Pidgeon, Anna M.; Thogmartin, Wayne E.; Radeloff, Volker C.

2015-01-01

The onset of spring plant growth has shifted earlier in the year over the past several decades due to rising global temperatures. Earlier spring onset may cause phenological mismatches between the availability of plant resources and dependent animals, and potentially lead to more false springs, when subsequent freezing temperatures damage new plant growth. We used the extended spring indices to project changes in spring onset, defined by leaf out and by first bloom, and predicted false springs until 2100 in the conterminous United States (US) using statistically-downscaled climate projections from the Coupled Model Intercomparison Project 5 ensemble. Averaged over our study region, the median shift in spring onset was 23 days earlier in the Representative Concentration Pathway 8.5 scenario with particularly large shifts in the Western US and the Great Plains. Spatial variation in phenology was due to the influence of short-term temperature changes around the time of spring onset versus season long accumulation of warm temperatures. False spring risk increased in the Great Plains and portions of the Midwest, but remained constant or decreased elsewhere. We conclude that global climate change may have complex and spatially variable effects on spring onset and false springs, making local predictions of change difficult.

An Analysis of the Dimensionality of the Pupil Control Ideology Scale.

ERIC Educational Resources Information Center

Graham, Steve; And Others

1985-01-01

The present study replicated an earlier investigation using the Pupil Control Ideology (PCI). The findings were congruent with earlier results. Consequently, it was recommended that the PCI should be refined and that the 10 item, unidimensional scale should be used in future investigations. (Author/LMO)

The Miocene mammal Necrolestes demonstrates the survival of a Mesozoic nontherian lineage into the late Cenozoic of South America

PubMed Central

Rougier, Guillermo W.; Wible, John R.; Beck, Robin M. D.; Apesteguía, Sebastian

2012-01-01

The early Miocene mammal Necrolestes patagonensis from Patagonia, Argentina, was described in 1891 as the only known extinct placental “insectivore” from South America (SA). Since then, and despite the discovery of additional well-preserved material, the systematic status of Necrolestes has remained in flux, with earlier studies leaning toward placental affinities and more recent ones endorsing either therian or specifically metatherian relationships. We have further prepared the best-preserved specimens of Necrolestes and compared them with newly discovered nontribosphenic Mesozoic mammals from Argentina; based on this, we conclude that Necrolestes is related neither to marsupials nor placentals but is a late-surviving member of the recently recognized nontherian clade Meridiolestida, which is currently known only from SA. This conclusion is supported by a morphological phylogenetic analysis that includes a broad sampling of therian and nontherian taxa and that places Necrolestes within Meridiolestida. Thus, Necrolestes is a remnant of the highly endemic Mesozoic fauna of nontribosphenic mammals in SA and extends the known record of meridiolestidans by almost 45 million years. Together with other likely relictual mammals from earlier in the Cenozoic of SA and Antarctica, Necrolestes demonstrates the ecological diversity of mammals and the mosaic pattern of fauna replacement in SA during the Cenozoic. In contrast to northern continents, the Cenozoic faunal history of SA was characterized by a long period of interaction between endemic mammalian lineages of Mesozoic origin and metatherian and eutherian lineages that probably dispersed to SA during the latest Cretaceous or earliest Paleocene. PMID:23169652

Genome-wide association study of the age of onset of childhood asthma.

PubMed

Forno, Erick; Lasky-Su, Jessica; Himes, Blanca; Howrylak, Judie; Ramsey, Clare; Brehm, John; Klanderman, Barbara; Ziniti, John; Melén, Erik; Pershagen, Goran; Wickman, Magnus; Martinez, Fernando; Mauger, Dave; Sorkness, Christine; Tantisira, Kelan; Raby, Benjamin A; Weiss, Scott T; Celedón, Juan C

2012-07-01

Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children. We sought to identify genetic variants associated with earlier onset of childhood asthma. We conducted the first genome-wide association study of the age of onset of childhood asthma among participants in the Childhood Asthma Management Program (CAMP) and used 3 independent cohorts from North America, Costa Rica, and Sweden for replication. Two single nucleotide polymorphisms (SNPs) were associated with earlier onset of asthma in the combined analysis of CAMP and the replication cohorts: rs9815663 (Fisher P= 2.31 × 10(-8)) and rs7927044 (P= 6.54 × 10(-9)). Of these 2 SNPs, rs9815663 was also significantly associated with earlier asthma onset in an analysis including only the replication cohorts. Ten SNPs in linkage disequilibrium with rs9815663 were also associated with earlier asthma onset (2.24 × 10(-7)

Debris Examination Using Ballistic and Radar Integrated Software

NASA Technical Reports Server (NTRS)

Griffith, Anthony; Schottel, Matthew; Lee, David; Scully, Robert; Hamilton, Joseph; Kent, Brian; Thomas, Christopher; Benson, Jonathan; Branch, Eric; Hardman, Paul;

Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models.

PubMed

Eaton, Jeffrey W; Menzies, Nicolas A; Stover, John; Cambiano, Valentina; Chindelevitch, Leonid; Cori, Anne; Hontelez, Jan A C; Humair, Salal; Kerr, Cliff C; Klein, Daniel J; Mishra, Sharmistha; Mitchell, Kate M; Nichols, Brooke E; Vickerman, Peter; Bakker, Roel; Bärnighausen, Till; Bershteyn, Anna; Bloom, David E; Boily, Marie-Claude; Chang, Stewart T; Cohen, Ted; Dodd, Peter J; Fraser, Christophe; Gopalappa, Chaitra; Lundgren, Jens; Martin, Natasha K; Mikkelsen, Evelinn; Mountain, Elisa; Pham, Quang D; Pickles, Michael; Phillips, Andrew; Platt, Lucy; Pretorius, Carel; Prudden, Holly J; Salomon, Joshua A; van de Vijver, David A M C; de Vlas, Sake J; Wagner, Bradley G; White, Richard G; Wilson, David P; Zhang, Lei; Blandford, John; Meyer-Rath, Gesine; Remme, Michelle; Revill, Paul; Sangrujee, Nalinee; Terris-Prestholt, Fern; Doherty, Meg; Shaffer, Nathan; Easterbrook, Philippa J; Hirnschall, Gottfried; Hallett, Timothy B

2014-01-01

New WHO guidelines recommend initiation of antiretroviral therapy for HIV-positive adults with CD4 counts of 500 cells per μL or less, a higher threshold than was previously recommended. Country decision makers have to decide whether to further expand eligibility for antiretroviral therapy accordingly. We aimed to assess the potential health benefits, costs, and cost-effectiveness of various eligibility criteria for adult antiretroviral therapy and expanded treatment coverage. We used several independent mathematical models in four settings-South Africa (generalised epidemic, moderate antiretroviral therapy coverage), Zambia (generalised epidemic, high antiretroviral therapy coverage), India (concentrated epidemic, moderate antiretroviral therapy coverage), and Vietnam (concentrated epidemic, low antiretroviral therapy coverage)-to assess the potential health benefits, costs, and cost-effectiveness of various eligibility criteria for adult antiretroviral therapy under scenarios of existing and expanded treatment coverage, with results projected over 20 years. Analyses assessed the extension of eligibility to include individuals with CD4 counts of 500 cells per μL or less, or all HIV-positive adults, compared with the previous (2010) recommendation of initiation with CD4 counts of 350 cells per μL or less. We assessed costs from a health-system perspective, and calculated the incremental cost (in US$) per disability-adjusted life-year (DALY) averted to compare competing strategies. Strategies were regarded very cost effective if the cost per DALY averted was less than the country's 2012 per-head gross domestic product (GDP; South Africa: $8040; Zambia: $1425; India: $1489; Vietnam: $1407) and cost effective if the cost per DALY averted was less than three times the per-head GDP. In South Africa, the cost per DALY averted of extending eligibility for antiretroviral therapy to adult patients with CD4 counts of 500 cells per μL or less ranged from $237 to $1691 per DALY averted compared with 2010 guidelines. In Zambia, expansion of eligibility to adults with a CD4 count threshold of 500 cells per μL ranged from improving health outcomes while reducing costs (ie, dominating the previous guidelines) to $749 per DALY averted. In both countries results were similar for expansion of eligibility to all HIV-positive adults, and when substantially expanded treatment coverage was assumed. Expansion of treatment coverage in the general population was also cost effective. In India, the cost for extending eligibility to all HIV-positive adults ranged from $131 to $241 per DALY averted, and in Vietnam extending eligibility to patients with CD4 counts of 500 cells per μL or less cost $290 per DALY averted. In concentrated epidemics, expanded access for key populations was also cost effective. Our estimates suggest that earlier eligibility for antiretroviral therapy is very cost effective in low-income and middle-income settings, although these estimates should be revisited when more data become available. Scaling up antiretroviral therapy through earlier eligibility and expanded coverage should be considered alongside other high-priority health interventions competing for health budgets. Bill & Melinda Gates Foundation, WHO. Copyright © 2014 Eaton et al. Open Access article distributed under the terms of CC BY-NC-ND. Published by .. All rights reserved.

Timing of metamorphism of the Lansang gneiss and implications for left-lateral motion along the Mae Ping (Wang Chao) strike-slip fault, Thailand

NASA Astrophysics Data System (ADS)

Palin, R. M.; Searle, M. P.; Morley, C. K.; Charusiri, P.; Horstwood, M. S. A.; Roberts, N. M. W.

2013-10-01

The Mae Ping fault (MPF), western Thailand, exhibits dominantly left-lateral strike-slip motion and stretches for >600 km, reportedly branching off the right-lateral Sagaing fault in Myanmar and extending southeast towards Cambodia. Previous studies have suggested that the fault assisted the large-scale extrusion of Sundaland that occurred during the Late Eocene-Early Oligocene, with a geological offset of ˜120-150 km estimated from displaced high-grade gneisses and granites of the Chiang Mai-Lincang belt. Exposures of high-grade orthogneiss in the Lansang National Park, part of this belt, locally contain strong mylonitic textures and are bounded by strike-slip ductile shear zones and brittle faults. Geochronological analysis of monazite from a sample of sheared biotite-K-feldspar orthogneiss suggests two episodes of crystallization, with core regions documenting Th-Pb ages between c. 123 and c. 114 Ma and rim regions documenting a significantly younger age range between c. 45-37 Ma. These data are interpreted to represent possible magmatic protolith emplacement for the Lansang orthogneiss during the Early Cretaceous, with a later episode of metamorphism occurring during the Eocene. Textural relationships provided by in situ analysis suggest that ductile shearing along the MPF occurred during the latter stages of, or after, this metamorphic event. In addition, monazite analyzed from an undeformed garnet-two-mica granite dyke intruding metamorphic units at Bhumipol Lake outside of the Mae Ping shear zone produced a Th-Pb age of 66.2 ± 1.6 Ma. This age is interpreted to date the timing of dyke emplacement, implying that the MPF cuts through earlier formed magmatic and high-grade metamorphic rocks. These new data, when combined with regional mapping and earlier geochronological work, show that neither metamorphism, nor regional cooling, was directly related to strike-slip motion.

How does cognitive load influence speech perception? An encoding hypothesis.

PubMed

Mitterer, Holger; Mattys, Sven L

2017-01-01

Two experiments investigated the conditions under which cognitive load exerts an effect on the acuity of speech perception. These experiments extend earlier research by using a different speech perception task (four-interval oddity task) and by implementing cognitive load through a task often thought to be modular, namely, face processing. In the cognitive-load conditions, participants were required to remember two faces presented before the speech stimuli. In Experiment 1, performance in the speech-perception task under cognitive load was not impaired in comparison to a no-load baseline condition. In Experiment 2, we modified the load condition minimally such that it required encoding of the two faces simultaneously with the speech stimuli. As a reference condition, we also used a visual search task that in earlier experiments had led to poorer speech perception. Both concurrent tasks led to decrements in the speech task. The results suggest that speech perception is affected even by loads thought to be processed modularly, and that, critically, encoding in working memory might be the locus of interference.

Quantum information versus black hole physics: deep firewalls from narrow assumptions

NASA Astrophysics Data System (ADS)

Braunstein, Samuel L.; Pirandola, Stefano

2018-07-01

The prevalent view that evaporating black holes should simply be smaller black holes has been challenged by the firewall paradox. In particular, this paradox suggests that something different occurs once a black hole has evaporated to one-half its original surface area. Here, we derive variations of the firewall paradox by tracking the thermodynamic entropy within a black hole across its entire lifetime and extend it even to anti-de Sitter space-times. Our approach sweeps away many unnecessary assumptions, allowing us to demonstrate a paradox exists even after its initial onset (when conventional assumptions render earlier analyses invalid). The most natural resolution may be to accept firewalls as a real phenomenon. Further, the vast entropy accumulated implies a deep firewall that goes `all the way down' in contrast with earlier work describing only a structure at the horizon. This article is part of a discussion meeting issue `Foundations of quantum mechanics and their impact on contemporary society'.

Seasonal abundance and vertical distribution of capelin (Mallotus villosus) in relation to water temperature at a coastal site off eastern Newfoundland

USGS Publications Warehouse

Methven, David A.; Piatt, John F.

1991-01-01

The seasonal abundance and vertical distribution of capelin in relation to water temperature have been investigated by conducting repeated hydroacoustic surveys at a coastal site off eastern Newfoundland. Water temperatures were warmer in 1983 than in 1984 as indicated by the earlier appearance and greater depth of the seasonal thermocline. Correspondingly, schools of capelin appeared earlier, were more abundant, and extended deeper in the water column in 1983 than in 1984. Most capelin were found between the surface and the 5°C isotherm. In both years, initial peaks of capelin abundance occurred when nearshore water temperatures increased from about 0-1°C to above 6°C and, at or near, periods of maximum tidal oscillation. Short-term variations in the depth of the 5°C isotherm were related to nearshore wind-induced upwelling events. Annual variations corresponded to the volume of cold (>0°C) water and sea-ice transported south by the Labrador Current.

Reforming of glucose and wood at the critical conditions of water

NASA Technical Reports Server (NTRS)

Modell, M.

1977-01-01

Reforming of organics in aqueous solutions is being investigated as a potential waste treatment process. Earlier studies showed that glucose in water reacts to form a gaseous mixture of CO, H2, CH4, CO2, C2H6, and C2H4 in the vicinity of the critical conditions of water (374 C, 22 MPa). The earlier work has been extended to determine the effect of variations in temperature and feed concentration on the extent of gasification. The percent gasification decreases with increasing feed concentration, indicating an overall kinetic order less than unity. Surprisingly, the percent gasification decreases with increasing temperature. A number of preliminary experiments were conducted with maple sawdust feed, which was thought to be representative of complex organic wastes from paper and vegetable matter. Once again, no solid products were found under the critical conditions; the percent gasification ranged from 16 to 88 percent, depending on the feed composition and residence time.

DOE Office of Scientific and Technical Information (OSTI.GOV)

James, K.H.

A prolific hydrocarbon province extends across the northern margin of South America from Colombia to east of Trinidad. Two key components are a world-class source rock, formed on a regional Late Cretaceous passive margin, and a complex tectonic setting in which a variety of structural and stratigraphic traps, reservoirs, seals and hydrocarbon kitchens have evolved through time. Convergence between the Farallon and Caribbean plates with South America culminated in the late Cretaceous-early Palaeogene with emplacement of Colombia`s Central Cordillera in the west and a nappe-foreland basin system in the north. Regional hydrocarbon generation probably occurred below associated basins. Subsequent obliquemore » convergence between the Caribbean and South America, partitioned into strike-slip and compressional strain, generated an eastward migrating and ongoing uplift-foredeep (kitchen) system from central Venezuela to Trinidad. Similarly, oblique interaction of western Colombia with the Nazca Plate caused segmentation of the earlier orogen, northward extrusion of elements such as the Maracaibo Block, and eastward migration of uplift progressively dividing earlier kitchens into localized foredeeps.« less

Quantum information versus black hole physics: deep firewalls from narrow assumptions.

PubMed

Braunstein, Samuel L; Pirandola, Stefano

2018-07-13

The prevalent view that evaporating black holes should simply be smaller black holes has been challenged by the firewall paradox. In particular, this paradox suggests that something different occurs once a black hole has evaporated to one-half its original surface area. Here, we derive variations of the firewall paradox by tracking the thermodynamic entropy within a black hole across its entire lifetime and extend it even to anti-de Sitter space-times. Our approach sweeps away many unnecessary assumptions, allowing us to demonstrate a paradox exists even after its initial onset (when conventional assumptions render earlier analyses invalid). The most natural resolution may be to accept firewalls as a real phenomenon. Further, the vast entropy accumulated implies a deep firewall that goes 'all the way down' in contrast with earlier work describing only a structure at the horizon.This article is part of a discussion meeting issue 'Foundations of quantum mechanics and their impact on contemporary society'. © 2018 The Author(s).

Imaging of the gravitational lens system PG 1115+080 with the Hubble Space Telescope

NASA Technical Reports Server (NTRS)

Kristian, Jerome; Groth, Edward J.; Shaya, Edward J.; Schneider, Donald P.; Holtzman, Jon A.; Baum, William A.; Campbell, Bel; Code, Arthur; Currie, Douglas G.; Danielson, G. E.

1993-01-01

This paper is the first of a series presenting observations of gravitational lenses and lens candidates, taken with the Wide Field/Planetary Camera of the HST. We have resolved the gravitational lens system PG 1115+080 into four point sources and a red, extended object that is presumably the lens galaxy; we present accurate relative intensities, colors, and positions of the four images, and lower accuracy intensity and position of the lens galaxy, all at the epoch 1991.2. Comparison with earlier data shows no compelling evidence for relative intensity variations between the QSO components having so far been observed. The new data agree with earlier conclusions that the system is rather simple, and can be produced by the single observed galaxy. The absence of asymmetry in the HST images implies that the emitting region of the quasar itself has an angular radius smaller than about 10 milliarcsec (100 pc for H0 = 50, q0 = 0.5).

Back to Basic: Aesthetic Experiences with Literature and Discovering the World

ERIC Educational Resources Information Center

Tice, Kathleen C.

2008-01-01

In this article, the author shares a current analysis of data that complements findings from earlier, related research that confirms the emotional aspects of reading experiences. The data from the earlier study is based upon comments by graduate students in online discussion groups, where they share their thoughts about the professional readings…

Right Limits and Reflectionless Measures for CMV Matrices

NASA Astrophysics Data System (ADS)

Breuer, Jonathan; Ryckman, Eric; Zinchenko, Maxim

2009-11-01

We study CMV matrices by focusing on their right-limit sets. We prove a CMV version of a recent result of Remling dealing with the implications of the existence of absolutely continuous spectrum, and we study some of its consequences. We further demonstrate the usefulness of right limits in the study of weak asymptotic convergence of spectral measures and ratio asymptotics for orthogonal polynomials by extending and refining earlier results of Khrushchev. To demonstrate the analogy with the Jacobi case, we recover corresponding previous results of Simon using the same approach.

Quantum-field-theoretical approach to phase–space techniques: Symmetric Wick theorem and multitime Wigner representation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plimak, L.I., E-mail: Lev.Plimak@mbi-berlin.de; Olsen, M.K.

2014-12-15

In this work we present the formal background used to develop the methods used in earlier works to extend the truncated Wigner representation of quantum and atom optics in order to address multi-time problems. Analogs of Wick’s theorem for the Weyl ordering are verified. Using the Bose–Hubbard chain as an example, we show how these may be applied to constructing a mapping of the system in question to phase space. Regularisation issues and the reordering problem for the Heisenberg operators are addressed.

Effects of Number Scaling on Entangled States in Quantum Mechanics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benioff, Paul

A summary of number structure scaling is followed by a description of the effects of number scaling in nonrelativistic quantum mechanics. The description extends earlier work to include the effects on the states of two or more interacting particles. Emphasis is placed on the effects on entangled states. The resulting scaling field is generalized to describe the effects on these states. It is also seen that one can use fiber bundles with fibers associated with single locations of the underlying space to describe the effects of scaling on arbitrary numbers of particles.

Laminar Soot Processes (Lsp) Experiment: Findings From Ground-Based Measurements

NASA Technical Reports Server (NTRS)

Kim, C. H.; El-Leathy, A. M.; Faeth, G. M.; Xu, F.

2003-01-01

Processes of soot formation and oxidation must be understood in order to achieve reliable computational combustion calculations for nonpremixed (diffusion) flames involving hydrocarbon fuels. Motivated by this observation, the present investigation extended earlier work on soot formation and oxidation in laminar jet ethylene/air and methane/oxygen premixed and acetylene-nitrogen/air diffusion flames at atmospheric pressure in this laboratory, emphasizing soot surface growth and early soot surface oxidation in laminar diffusion flames fueled with a variety of hydrocarbons at pressures in the range 0.1 - 1.0 atm.

International Conference on Multiphoton Processes (4th) Held in Boulder, Colorado on July 13-17, 1987: Program and Abstracts.

DTIC Science & Technology

1988-07-01

depend on the duration of the pulse . The earlier results are nov extended to laser intensities of the order of 1012-10 13W/cm 2. The description of...projection operator formalism, described in (1) to analyze a state of a hydrogen atom in a very intense laser field. A starting Hamiltonian in dipole...system. The results of the microwave experiments are expected to scale to the case of excited multiply-charged hydrogenic ions in intense short- pulse

IUS with Magellan spacecraft drifts into space after STS-30 deployment

NASA Image and Video Library

1989-05-04

STS030-71-063 (4 May 1989) --- This scene is one of two released by NASA showing the process of solar array panel deployment on the Magellan spacecraft. Panels are not fully extended in this frame. The spacecraft had earlier been released by the STS-30 crewmembers to begin its long journey to the planet Venus for an extensive radar mapping mission. The frame was photographed through Atlantis? aft flight deck windows with a handheld 70mm camera. The complementary photograph is STS030-71-070.

Electronic Structure of Alpha-Quartz and the Influence of Some Local Disorder: A Tight Binding Study,

DTIC Science & Technology

1977-01-01

An s extended summary of the theoretical and ex- perimental work on Si02 is to be found in that paper. The tight-binding basis con- sists of the four... theoretical and experimental works contained therein. 4. B. Fischer, R. A. Pollak, T. H. Distefano and W. D. Grobman, "Electronic Structure of SiO 2, SixGe 1 x...and GeO 2 from Photoemission Spectroscopy," Phys. Rev. BI5, 3193 (1977), and references to earlier works therein. 5. J. H. Scofield , "Hartree-Slater

Stimulated Raman signals at conical intersections: Ab initio surface hopping simulation protocol with direct propagation of the nuclear wave function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kowalewski, Markus, E-mail: mkowalew@uci.edu; Mukamel, Shaul, E-mail: smukamel@uci.edu

2015-07-28

Femtosecond Stimulated Raman Spectroscopy (FSRS) signals that monitor the excited state conical intersections dynamics of acrolein are simulated. An effective time dependent Hamiltonian for two C—H vibrational marker bands is constructed on the fly using a local mode expansion combined with a semi-classical surface hopping simulation protocol. The signals are obtained by a direct forward and backward propagation of the vibrational wave function on a numerical grid. Earlier work is extended to fully incorporate the anharmonicities and intermode couplings.

The application of eigensymmetries of face forms to X-ray diffraction intensities of crystals twinned by `reticular merohedry'

NASA Astrophysics Data System (ADS)

Klapper, H.; Hahn, Th

2012-01-01

Crystallographic face forms {hkl} are interpreted as sets of symmetry-equivalent X-ray reflections. Extending an earlier paper on twinning by merohedry [ [Sigma] = 1, Klapper & Hahn (2010). Acta Cryst. A66, 327-346], the eigensymmetry of these forms is used to derive general relations between the diffraction intensities of overlapping twin-related reflections. The following twins by reticular merohedry are treated: [Sigma] 3 twins of rhombohedral and cubic, [Sigma] 5 twins of tetragonal and [Sigma] 7 twins of hexagonal crystals.

A Bayesian approach to reliability and confidence

NASA Technical Reports Server (NTRS)

Barnes, Ron

1989-01-01

The historical evolution of NASA's interest in quantitative measures of reliability assessment is outlined. The introduction of some quantitative methodologies into the Vehicle Reliability Branch of the Safety, Reliability and Quality Assurance (SR and QA) Division at Johnson Space Center (JSC) was noted along with the development of the Extended Orbiter Duration--Weakest Link study which will utilize quantitative tools for a Bayesian statistical analysis. Extending the earlier work of NASA sponsor, Richard Heydorn, researchers were able to produce a consistent Bayesian estimate for the reliability of a component and hence by a simple extension for a system of components in some cases where the rate of failure is not constant but varies over time. Mechanical systems in general have this property since the reliability usually decreases markedly as the parts degrade over time. While they have been able to reduce the Bayesian estimator to a simple closed form for a large class of such systems, the form for the most general case needs to be attacked by the computer. Once a table is generated for this form, researchers will have a numerical form for the general solution. With this, the corresponding probability statements about the reliability of a system can be made in the most general setting. Note that the utilization of uniform Bayesian priors represents a worst case scenario in the sense that as researchers incorporate more expert opinion into the model, they will be able to improve the strength of the probability calculations.

Alterations of DNA content in human endometrial stromal cells transfected with a temperature-sensitive SV40: tetraploidization and physiological consequences.

PubMed

Rinehart, C A; Mayben, J P; Butler, T D; Haskill, J S; Kaufman, D G

1992-01-01

The normal genomic stability of human cells is reversed during neoplastic transformation. The SV40 large T antigen alters the DNA content in human endometrial stromal cells in a manner that relates to neoplastic progression. Human endometrial stromal cells were transfected with a plasmid containing the A209 temperature-sensitive mutant of SV40 (tsSV40), which is also defective in the viral origin of replication. Ninety-seven clonal transfectants from seven different primary cell strains were isolated. Initial analysis revealed that 20% of the clonal populations (19/97) had an apparent diploid DNA content, 35% (34/97) had an apparent tetraploid DNA content, and the remainder were mixed populations of diploid and tetraploid cells. No aneuploid populations were observed. Diploid tsSV40 transformed cells always give rise to a population of cells with a tetraploid DNA content when continuously cultured at the permissive temperature. The doubling of DNA content can be vastly accelerated by the sudden reintroduction of large T antigen activity following a shift from non-permissive to permissive temperature. Tetraploid tsSV40 transfected cells have a lower capacity for anchorage-independent growth and earlier entry into 'crisis' than diploid cells. These results indicate that during the pre-crisis, extended lifespan phase of growth, the SV40 large T antigen causes a doubling of DNA content. This apparent doubling of DNA content does not confer growth advantage during the extended lifespan that precedes 'crisis'.

Optimisation of an idealised primitive equation ocean model using stochastic parameterization

NASA Astrophysics Data System (ADS)

Cooper, Fenwick C.

2017-05-01

Using a simple parameterization, an idealised low resolution (biharmonic viscosity coefficient of 5 × 1012 m4s-1 , 128 × 128 grid) primitive equation baroclinic ocean gyre model is optimised to have a much more accurate climatological mean, variance and response to forcing, in all model variables, with respect to a high resolution (biharmonic viscosity coefficient of 8 × 1010 m4s-1 , 512 × 512 grid) equivalent. For example, the change in the climatological mean due to a small change in the boundary conditions is more accurate in the model with parameterization. Both the low resolution and high resolution models are strongly chaotic. We also find that long timescales in the model temperature auto-correlation at depth are controlled by the vertical temperature diffusion parameter and time mean vertical advection and are caused by short timescale random forcing near the surface. This paper extends earlier work that considered a shallow water barotropic gyre. Here the analysis is extended to a more turbulent multi-layer primitive equation model that includes temperature as a prognostic variable. The parameterization consists of a constant forcing, applied to the velocity and temperature equations at each grid point, which is optimised to obtain a model with an accurate climatological mean, and a linear stochastic forcing, that is optimised to also obtain an accurate climatological variance and 5 day lag auto-covariance. A linear relaxation (nudging) is not used. Conservation of energy and momentum is discussed in an appendix.

Selfie-Takers Prefer Left Cheeks: Converging Evidence from the (Extended) selfiecity Database

PubMed Central

Manovich, Lev; Ferrari, Vera; Bruno, Nicola

2017-01-01

According to previous reports, selfie takers in widely different cultural contexts prefer poses showing the left cheek more than the right cheek. This posing bias may be interpreted as evidence for a right-hemispheric specialization for the expression of facial emotions. However, earlier studies analyzed selfie poses as categorized by human raters, which raises methodological issues in relation to the distinction between frontal and three-quarter poses. Here, we provide converging evidence by analyzing the (extended) selfiecity database which includes automatic assessments of head rotation and of emotional expression. We confirm a culture- and sex-independent left-cheek bias and report stronger expression of negative emotions in selfies showing the left cheek. These results are generally consistent with a psychobiological account of a left cheek bias in self-portraits but reveal possible unexpected facts concerning the relation between side bias and lateralization of emotional expression. PMID:28928683

Corrrelation of the Specific Rates of Solvolysis of Ethyl Fluoroformate Using the Extended Grunwald-Winstein Equation

PubMed Central

Seong, Mi Hye; Kyong, Jin Burm; Lee, Young Hoon; Kevill, Dennis N.

2009-01-01

The specific rates of solvolysis of ethyl fluoroformate have been measured at 24.2 °C in 21 pure and binary solvents. These give a satisfactory correlation over the full range of solvents when the extended Grunwald-Winstein equation is applied. The sensitivities to changes in the NT solvent nucleophilicity scale and the YCl solvent ionizing power scale, and the kF/kCl values are very similar to those for solvolyses of n-octyl fluoroformate, consistent with the addition step of an addition-elimination pathway being rate-determining. For methanolysis, a solvent deuterium isotope effect of 3.10 is compatible with the incorporation of general-base catalysis into the substitution process. For five representative solvents, studies were made at several temperatures and activation parameters determined. The results are also compared with those reported earlier for ethyl chloroformate and mechanistic conclusions are drawn. PMID:19399229

Types of verbal interaction with instructable robots

NASA Technical Reports Server (NTRS)

Crangle, C.; Suppes, P.; Michalowski, S.

1987-01-01

An instructable robot is one that accepts instruction in some natural language such as English and uses that instruction to extend its basic repertoire of actions. Such robots are quite different in conception from autonomously intelligent robots, which provide the impetus for much of the research on inference and planning in artificial intelligence. Examined here are the significant problem areas in the design of robots that learn from vebal instruction. Examples are drawn primarily from our earlier work on instructable robots and recent work on the Robotic Aid for the physically disabled. Natural-language understanding by machines is discussed as well as in the possibilities and limits of verbal instruction. The core problem of verbal instruction, namely, how to achieve specific concrete action in the robot in response to commands that express general intentions, is considered, as are two major challenges to instructability: achieving appropriate real-time behavior in the robot, and extending the robot's language capabilities.

The stratigraphic record of recent climate change in mid-Atlantic USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brush, G.S.; Hilgartner, W.B.; Khan, H.

1994-06-01

The Medieval Warm Period and Little Ice Age recorded in sediments deposited in tributaries and marshes surrounding the Chesapeake and Delaware Bays in the mid-Atlantic region of USA, by changes in pollen and seeds of terrestrial and aquatic plants, and changes in influxes of charcoal, sediment, metals and nutrients. Fossil pollen and seeds portray a regional landscape characterized by conditions drier that present from about 1000 to 1200 AD. During the same period, high charcoal and sediment influxes indicate high fire frequency. This short dry interval was followed by an expansion of submerged aquatic plants, low marsh plants, and terrestrialmore » plants that occupy wet habitats. Charcoal influxes are extremely low during the latter interval, which extended from about 1200 AD to 1500 AD. Plant macrofossil and pollen distributions indicate a second dry period extending from 1550 to 1650 AD, which appears similar to the earlier Medieval Warm interval.« less

Contribution of Small-Scale Correlated Fluctuations of Microstructural Properties of a Spatially Extended Geophysical Target Under the Assessment of Radar Backscatter

NASA Technical Reports Server (NTRS)

Yurchak, Boris S.

2010-01-01

The study of the collective effects of radar scattering from an aggregation of discrete scatterers randomly distributed in a space is important for better understanding the origin of the backscatter from spatially extended geophysical targets (SEGT). We consider the microstructure irregularities of a SEGT as the essential factor that affect radar backscatter. To evaluate their contribution this study uses the "slice" approach: particles close to the front of incident radar wave are considered to reflect incident electromagnetic wave coherently. The radar equation for a SEGT is derived. The equation includes contributions to the total backscatter from correlated small-scale fluctuations of the slice's reflectivity. The correlation contribution changes in accordance with an earlier proposed idea by Smith (1964) based on physical consideration. The slice approach applied allows parameterizing the features of the SEGT's inhomogeneities.

Arbitrary-Order Conservative and Consistent Remapping and a Theory of Linear Maps: Part II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ullrich, Paul A.; Devendran, Dharshi; Johansen, Hans

2016-04-01

The focus on this series of articles is on the generation of accurate, conservative, consistent, and (optionally) monotone linear offline maps. This paper is the second in the series. It extends on the first part by describing four examples of 2D linear maps that can be constructed in accordance with the theory of the earlier work. The focus is again on spherical geometry, although these techniques can be readily extended to arbitrary manifolds. The four maps include conservative, consistent, and (optionally) monotone linear maps (i) between two finite-volume meshes, (ii) from finite-volume to finite-element meshes using a projection-type approach, (iii)more » from finite-volume to finite-element meshes using volumetric integration, and (iv) between two finite-element meshes. Arbitrary order of accuracy is supported for each of the described nonmonotone maps.« less

Cardiac Complications, Earlier Treatment, and Initial Disease Severity in Kawasaki Disease.

PubMed

Abrams, Joseph Y; Belay, Ermias D; Uehara, Ritei; Maddox, Ryan A; Schonberger, Lawrence B; Nakamura, Yosikazu

2017-09-01

To assess if observed higher observed risks of cardiac complications for patients with Kawasaki disease (KD) treated earlier may reflect bias due to confounding from initial disease severity, as opposed to any negative effect of earlier treatment. We used data from Japanese nationwide KD surveys from 1997 to 2004. Receipt of additional intravenous immunoglobulin (IVIG) (data available all years) or any additional treatment (available for 2003-2004) were assessed as proxies for initial disease severity. We determined associations between earlier or later IVIG treatment (defined as receipt of IVIG on days 1-4 vs days 5-10 of illness) and cardiac complications by stratifying by receipt of additional treatment or by using logistic modeling to control for the effect of receiving additional treatment. A total of 48 310 patients with KD were included in the analysis. In unadjusted analysis, earlier IVIG treatment was associated with a higher risk for 4 categories of cardiac complications, including all major cardiac complications (risk ratio, 1.10; 95% CI, 1.06-1.15). Stratifying by receipt of additional treatment removed this association, and earlier IVIG treatment became protective against all major cardiac complications when controlling for any additional treatment in logistic regressions (OR, 0.90; 95% CI, 0.80-1.00). Observed higher risks of cardiac complications among patients with KD receiving IVIG treatment on days 1-4 of the illness are most likely due to underlying higher initial disease severity, and patients with KD should continue to be treated with IVIG as early as possible. Published by Elsevier Inc.

Physical and cognitive capability in mid-adulthood as determinants of retirement and extended working life in a British cohort study.

PubMed

Stafford, Mai; Cooper, Rachel; Cadar, Dorina; Carr, Ewan; Murray, Emily; Richards, Marcus; Stansfeld, Stephen; Zaninotto, Paola; Head, Jenny; Kuh, Diana

2017-01-01

Objective Policy in many industrialized countries increasingly emphasizes extended working life. We examined associations between physical and cognitive capability in mid-adulthood and work in late adulthood. Methods Using self-reported physical limitations and performance-based physical and cognitive capability at age 53, assessed by trained nurses from the Medical Research Council (MRC) National Survey of Health and Development, we examined prospective associations with extended working (captured by age at and reason for retirement from main occupation, bridge employment in paid work after retirement from the main occupation, and voluntary work participation) up to age 68 among >2000 men and women. Results Number of reported physical limitations at age 53 was associated with higher likelihood of retiring for negative reasons and lower likelihood of participating in bridge employment, adjusted for occupational class, education, partner's employment, work disability at age 53, and gender. Better performance on physical and cognitive tests was associated with greater likelihood of participating in bridge or voluntary work. Cognitive capability in the top 10% compared with the middle 80% of the distribution was associated with an odds ratio of bridge employment of 1.71 [95% confidence interval (95% CI) 1.21-2.42]. Conclusions The possibility for an extending working life is less likely to be realized by those with poorer midlife physical or cognitive capability, independently of education, and social class. Interventions to promote capability, starting in mid-adulthood or earlier, could have long-term consequences for extending working.

The Detection of Circumnuclear X-Ray Emission from the Seyfert Galaxy NGC 3516

NASA Technical Reports Server (NTRS)

George, I. M.; Turner, T. J.; Netzer, H.; Kraemer, S. B.; Ruiz, J.; Chelouche, D.; Crenshaw, D. M.; Yaqoob, T.; Nandra, K.; Mushotzky, R. F.;

Predicting the patterns of change in spring onset and false springs in China during the twenty-first century

NASA Astrophysics Data System (ADS)

Zhu, Likai; Meng, Jijun; Li, Feng; You, Nanshan

2017-10-01

Spring onset has generally shifted earlier in China over the past several decades in response to the warming climate. However, future changes in spring onset and false springs, which will have profound effects on ecosystems, are still not well understood. Here, we used the extended form of the Spring Indices model (SI-x) to project changes in the first leaf and first bloom dates, and predicted false springs for the historical (1950-2005) and future (2006-2100) periods based on the downscaled daily maximum/minimum temperatures under two emission scenarios from 21 General Circulation Models (GCMs) of the Coupled Model Intercomparison Project Phase 5 (CMIP5). On average, first leaf and first bloom in China were projected to occur 21 and 23 days earlier, respectively, by the end of the twenty-first century in the Representative Concentration Pathway (RCP) 8.5 scenario. Areas with greater earlier shifts in spring onset were in the warm temperate zone, as well as the north and middle subtropical zones of China. Early false spring risk increased rapidly in the warm temperate and north subtropical zones, while that declined in the cold temperate zone. Relative to early false spring risk, late false spring risk showed a common increase with smaller magnitude in the RCP 8.5 scenario but might cause greater damage to ecosystems because plants tend to become more vulnerable to the later occurrence of a freeze event. We conclude that future climate warming will continue to cause earlier occurrence of spring onset in general, but might counterintuitively increase plant damage risk in natural and agricultural systems of the warm temperate and subtropical China.

Predicting the patterns of change in spring onset and false springs in China during the twenty-first century.

PubMed

Zhu, Likai; Meng, Jijun; Li, Feng; You, Nanshan

2017-10-28

Spring onset has generally shifted earlier in China over the past several decades in response to the warming climate. However, future changes in spring onset and false springs, which will have profound effects on ecosystems, are still not well understood. Here, we used the extended form of the Spring Indices model (SI-x) to project changes in the first leaf and first bloom dates, and predicted false springs for the historical (1950-2005) and future (2006-2100) periods based on the downscaled daily maximum/minimum temperatures under two emission scenarios from 21 General Circulation Models (GCMs) of the Coupled Model Intercomparison Project Phase 5 (CMIP5). On average, first leaf and first bloom in China were projected to occur 21 and 23 days earlier, respectively, by the end of the twenty-first century in the Representative Concentration Pathway (RCP) 8.5 scenario. Areas with greater earlier shifts in spring onset were in the warm temperate zone, as well as the north and middle subtropical zones of China. Early false spring risk increased rapidly in the warm temperate and north subtropical zones, while that declined in the cold temperate zone. Relative to early false spring risk, late false spring risk showed a common increase with smaller magnitude in the RCP 8.5 scenario but might cause greater damage to ecosystems because plants tend to become more vulnerable to the later occurrence of a freeze event. We conclude that future climate warming will continue to cause earlier occurrence of spring onset in general, but might counterintuitively increase plant damage risk in natural and agricultural systems of the warm temperate and subtropical China.

Chiari malformation may increase perivascular cerebrospinal fluid flow into the spinal cord: A subject-specific computational modelling study.

PubMed

Lloyd, Robert A; Fletcher, David F; Clarke, Elizabeth C; Bilston, Lynne E

2017-12-08

Syringomyelia is associated with Chiari I malformation, although the mechanistic link is unclear. Studies have suggested that cerebrospinal fluid enters the spinal cord via the perivascular spaces, and that changes in the timing of the subarachnoid pressures may increase flow into the spinal cord. This study aims to determine how Chiari malformation and syringomyelia alter the subarachnoid space pressures and hence perivascular flow. Subject-specific models of healthy controls (N = 9), Chiari patients with (N = 7) and without (N = 8) syringomyelia, were developed from magnetic resonance imaging (MRI), to simulate the subarachnoid pressures. These pressures were input to an idealised model of the perivascular space to evaluate potential differences in perivascular flow. Peak pressures in Chiari patients without a syrinx were higher than in controls (46% increase; p = .029) and arrived earlier in the cardiac cycle than both controls (2.58% earlier; p = .045) and syrinx patients (2.85% earlier; p = .045). The perivascular model predicted Chiari patients without a syrinx would have the greatest flow into the cord (p < .05) if the arterial pulse delay was between 4 and 10% of the cardiac cycle. Using phase-contrast MRI the mean arterial delay for all subjects was similar, and was estimated as 4.7 ± 0.2%. The perivascular pumping rate showed a strong positive correlation (R Adj 2 =0.85; p < .0001) with extended periods of high pressure that arrived earlier in the cardiac cycle, suggesting these pressure characteristics may play a role in syrinx development. Copyright © 2017 Elsevier Ltd. All rights reserved.

Multicomponent Implant Releasing Dexamethasone

NASA Astrophysics Data System (ADS)

Nikkola, L.; Vapalahti, K.; Ashammakhi, N.

2008-02-01

Several inflammatory conditions are usually treated with corticosteroids. There are various problems like side effects with traditional applications of steroids, e.g. topical, or systemic routes. Local drug delivery systems have been studied and developed to gain more efficient administration with fewer side effects. Earlier, we reported on developing Dexamethasone (DX) releasing biodegradable fibers. However, their drug release properties were not satisfactory in terms of onset of drug release. Thus, we assessed the development of multicomponent (MC) implant to enhance earlier drug release from such biodegradable fibers. Poly (lactide-co-glycolide) (PLGA) and 2 wt-% and 8 wt-% DX were compounded and extruded with twin-screw extruder to form of fibers. Some of the fibers were sterilized to obtain a change in drug release properties. Four different fiber classes were studied: 2 wt-%, 8 wt-%, sterilized 2 wt-%, and sterilized 8 wt-%. 3×4 different DX-releasing fibers were then heat-pressed to form one multicomponent rod. Half of the rods where sterilized. Drug release was measured from initial fibers and multicomponent rods using a UV/VIS spectrometer. Shear strength and changes in viscosity were also measured. Drug release studies showed that drug release commenced earlier from multicomponent rods than from component fibers. Drug release from multicomponent rods lasted from day 30 to day 70. The release period of sterilized rods extended from day 23 to day 57. When compared to the original component fibers, the drug release from MC rods commenced earlier. The initial shear strength of MC rods was 135 MPa and decreased to 105 MPa during four weeks of immersion in phosphate buffer solution. Accordingly, heat pressing has a positive effect on drug release. After four weeks in hydrolysis, no disintegration was observed.

Joint probability of statistical success of multiple phase III trials.

PubMed

Zhang, Jianliang; Zhang, Jenny J

2013-01-01

In drug development, after completion of phase II proof-of-concept trials, the sponsor needs to make a go/no-go decision to start expensive phase III trials. The probability of statistical success (PoSS) of the phase III trials based on data from earlier studies is an important factor in that decision-making process. Instead of statistical power, the predictive power of a phase III trial, which takes into account the uncertainty in the estimation of treatment effect from earlier studies, has been proposed to evaluate the PoSS of a single trial. However, regulatory authorities generally require statistical significance in two (or more) trials for marketing licensure. We show that the predictive statistics of two future trials are statistically correlated through use of the common observed data from earlier studies. Thus, the joint predictive power should not be evaluated as a simplistic product of the predictive powers of the individual trials. We develop the relevant formulae for the appropriate evaluation of the joint predictive power and provide numerical examples. Our methodology is further extended to the more complex phase III development scenario comprising more than two (K > 2) trials, that is, the evaluation of the PoSS of at least k₀ (k₀≤ K) trials from a program of K total trials. Copyright © 2013 John Wiley & Sons, Ltd.

Soot Formation in Laminar Premixed Methane/Oxygen Flames at Atmospheric Pressure

NASA Technical Reports Server (NTRS)

Xu, F.; Lin, K.-C.; Faeth, G. M.

1998-01-01

Flame structure and soot formation were studied within soot-containing laminar premixed mc1hane/oxygen flames at atmospheric pressure. The following measurements were made: soot volume fractions by laser extinction, soot temperatures by multiline emission, gas temperatures (where soot was absent) by corrected fine-wire thermocouples, soot structure by thermophoretic sampling and transmission electron microscope (TEM), major gas species concentrations by sampling and gas chromatography, and gas velocities by laser velocimetry. Present measurements of gas species concentrations were in reasonably good agreement with earlier measurements due to Ramer et al. as well as predictions based on the detailed mechanisms of Frenklach and co-workers and Leung and Lindstedt: the predictions also suggest that H atom concentrations are in local thermodynamic equilibrium throughout the soot formation region. Using this information, it was found that measured soot surface growth rates could be correlated successfully by predictions based on the hydrogen-abstraction/carbon-addition (HACA) mechanisms of both Frenklach and co-workers and Colket and Hall, extending an earlier assessment of these mechanisms for premixed ethylene/air flames to conditions having larger H/C ratios and acetylene concentrations. Measured primary soot particle nucleation rates were somewhat lower than the earlier observations for laminar premixed ethylene/air flames and were significantly lower than corresponding rates in laminar diffusion flames. for reasons that still must be explained.

Soot Formation in Laminar Premixed Methane/Oxygen Flames at Atmospheric Pressure. Appendix H

NASA Technical Reports Server (NTRS)

Xu, F.; Lin, K.-C.; Faeth, G. M.; Urban, D. L. (Technical Monitor); Yuan, Z.-G. (Technical Monitor)

2001-01-01

Flame structure and soot formation were studied within soot-containing laminar premixed methanefoxygen flames at atmospheric pressure. The following measurements were made: soot volume fractions by laser extinction, soot temperatures by multiline emission, gas temperatures (where soot was absent) by corrected fine-wire thermocouples, soot structure by thermophoretic sampling and transmission electron microscope (TEM), major gas species concentrations by sampling and gas chromatography, and gas velocities by laser velocimetry. Present measurements of gas species concentrations were in reasonably good agreement with earlier measurements due to Ramer et al. as well as predictions based on the detailed mechanisms of Frenklach and co-workers and Leung and Lindstedt; the predictions also suggest that H atom concentrations are in local thermodynamic equilibrium throughout the soot formation region. Using this information, it was found that measured soot surface growth rates could be correlated successfully by predictions based on the hydrogenabstraction/carbon-addition (HACA) mechanisms of both Frenklach and co-workers and Colket and Hall, extending an earlier assessment of these mechanisms for premixed ethylene/air flames to conditions having larger H/C ratios and acetylene concentrations. Measured primary soot particle nucleation rates were somewhat lower than the earlier observations for laminar premixed ethylene/air flames and were significantly lower than corresponding rates in laminar diffusion flames, for reasons that still must be explained.

Evaluating the intensity of fire at the Acheulian site of Gesher Benot Ya'aqov-Spatial and thermoluminescence analyses.

PubMed

Alperson-Afil, Nira; Richter, Daniel; Goren-Inbar, Naama

2017-01-01

This manuscript presents an attempt to evaluate the intensity of fire through spatial patterning and thermoluminescence methodology. Previous studies of Layer II-6 Level 2 at the Acheulian site of Gesher Benot Ya'aqov suggested that hominins differentiated their activities across space, including multiple activities around a hearth reconstructed on the basis of the distribution of burned flint artifacts. A transect of ~4 m was extended from the center of the reconstructed hearth of Level 2 to its periphery in order to examine the intensity of fire. Burned and unburned flint microartifacts were sampled along this transect. The results of earlier and current thermoluminescence (TL) analysis demonstrate a general agreement with the macroscopic determination of burning, indicating that the possibility of misinterpretation based on macroscopic observations is negligible. The TL signal from flint microartifacts close to the hearth's center shows unambiguous signs of strong heating, whereas with increasing distance from the hearth the TL signal can be interpreted as a result of decreasing temperatures and/or shorter durations of exposure to fire in addition to a decreasing number of flints showing fire damage. Our study shows that TL analysis can identify some variation in fire intensity, which allows a more precise classification of burned flint microartifacts with respect to their heating history.

Martingales, detrending data, and the efficient market hypothesis

NASA Astrophysics Data System (ADS)

McCauley, Joseph L.; Bassler, Kevin E.; Gunaratne, Gemunu H.

2008-01-01

We discuss martingales, detrending data, and the efficient market hypothesis (EMH) for stochastic processes x( t) with arbitrary diffusion coefficients D( x, t). Beginning with x-independent drift coefficients R( t) we show that martingale stochastic processes generate uncorrelated, generally non-stationary increments. Generally, a test for a martingale is therefore a test for uncorrelated increments. A detrended process with an x-dependent drift coefficient is generally not a martingale, and so we extend our analysis to include the class of ( x, t)-dependent drift coefficients of interest in finance. We explain why martingales look Markovian at the level of both simple averages and 2-point correlations. And while a Markovian market has no memory to exploit and presumably cannot be beaten systematically, it has never been shown that martingale memory cannot be exploited in 3-point or higher correlations to beat the market. We generalize our Markov scaling solutions presented earlier, and also generalize the martingale formulation of the EMH to include ( x, t)-dependent drift in log returns. We also use the analysis of this paper to correct a misstatement of the ‘fair game’ condition in terms of serial correlations in Fama's paper on the EMH. We end with a discussion of Levy's characterization of Brownian motion and prove that an arbitrary martingale is topologically inequivalent to a Wiener process.

'Fingerprints' of central stimulatory drug effects by means of quantitative radioelectroencephalography in the rat (tele-stereo-EEG).

PubMed

Dimpfel, W; Spüler, M; Nickel, B; Tibes, U

1986-01-01

The new electrophysiological model earlier described as stereo-EEG is extended now to allow recording from the freely moving rat by means of a telemetric device. Chronic implantation of 4 electrodes into the brain allows simultaneous transmission of field potentials from frontal cortex, hippocampus, striatum and reticular formation. Frequency analysis of these potentials results in a drug-specific 'fingerprint' which cannot only be used to compare different chemicals with each other but also to detect onset and time dependence of drug actions. Application of the model to the question if fenetylline has its own intrinsic mode of action or merely develops its stimulatory effect after metabolic separation into its molecular moieties amphetamine and theophylline (prodrug hypothesis) revealed that fenetylline indeed displays its own stimulatory effect to the same extent and at a similar time course as amphetamine and theophylline. The 'fingerprint' as obtained by the analysis of the action of fenetylline in the rat resembles closely that obtained after the application of theophylline with respect to decreased alpha activity, but resembles amphetamine with respect to beta 1 activity. Thus the applied method allows studying structure function relationships as the action of fenetylline seems to reflect both its molecular moieties.

NEW CONSTRAINTS ON MASS-DEPENDENT DISRUPTION OF STAR CLUSTERS IN M51

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chandar, Rupali; Whitmore, Bradley C.; Regan, Michael

2011-02-01

We use UBVI H{alpha} images of the Whirlpool galaxy, M51, taken with the Advanced Camera for Surveys and WFPC2 cameras on the Hubble Space Telescope (HST) to select star clusters, and to estimate their masses and ages by comparing their observed colors with predictions from population synthesis models. We construct the mass function of intermediate-age (1-4 x 10{sup 8} yr) clusters, and find that it is well described by a power law, {psi}(M) {proportional_to} M{sup {beta}}, with {beta} = -2.1 {+-} 0.2, for clusters more massive than M {approx} 6 x 10{sup 3} M{sub sun}. This extends the mass functionmore » of intermediate-age clusters in M51 to masses lower by nearly a factor of five over previous determinations. The mass function does not show evidence for curvature at either the high or low mass end. This shape indicates that there is no evidence for the earlier disruption of lower mass clusters compared with their higher mass counterparts (i.e., no mass-dependent disruption) over the observed range of masses and ages, or for a physical upper mass limit M{sub C} with which clusters in M51 can form. These conclusions differ from previous suggestions based on poorer-quality HST observations. We discuss their implications for the formation and disruption of the clusters. Ages of clusters in two 'feathers', stellar features extending from the outer portion of a spiral arm, show that the feather with a larger pitch angle formed earlier, and over a longer period, than the other.« less

Guided Self-Help Treatment for Recurrent Binge Eating: Replication and Extension

PubMed Central

DeBar, Lynn L.; Striegel-Moore, Ruth H.; Wilson, G. Terence; Perrin, Nancy; Yarborough, Bobbi Jo; Dickerson, John; Lynch, Frances; Rosselli, Francine; Kraemer, Helena C.

2014-01-01

Objective The aim of this study was to replicate and extend results of a previous blended efficacy and effectiveness trial of a low-intensity, manual-based guided self-help form of cognitive-behavioral therapy (CBT-GSH) for the treatment of binge eating disorders in a large health maintenance organization (HMO) and to compare them with usual care. Methods To extend earlier findings, the investigators modified earlier recruitment and assessment approaches and conducted a randomized clinical trial to better reflect procedures that may be reasonably carried out in real-world practices. The intervention was delivered by master’s-level interventionists to 160 female members of a health maintenance organization who met diagnostic criteria for recurrent binge eating. Data collected at baseline, immediately posttreatment, and at six- and 12-month follow-ups were used in intent-to-treat analyses. Results At the 12-month follow-up, CBT-GSH resulted in greater remission from binge eating (35%, N=26) than usual care (14%, N=10) (number needed to treat=5). The CBT-GSH group also demonstrated greater improvements in dietary restraint (d=.71) and eating, shape, and weight concerns (d=1.10, 1.24, and .98, respectively) but not weight change. Conclusions Replication of the pattern of previous findings suggests that CBT-GSH is a robust treatment for patients with recurrent binge eating. The magnitude of changes was significantly smaller than in the original study, however, suggesting that patients recruited and assessed with less intensive procedures may respond differently from their counterparts enrolled in trials requiring more comprehensive procedures. PMID:21459987

On the spreading and instability of gravity current fronts of arbitrary shape

NASA Astrophysics Data System (ADS)

Zgheib, N.; Bonometti, T.; Balachandar, S.

2012-11-01

Experiments, simulations and theoretical analysis were carried out to study the influence of geometry on the spreading of gravity currents. The horizontal spreading of three different intial planforms of initial release were investigated: an extended ellipse, a cross, and a circle. The experiments used a pulley system for a swift nearly instantaneous release. The case of the axisymmetric cylinder compared favorably with earlier simulations. We ran experiments for multiple aspect ratios for all three configurations. Perhaps the most intriguing of the three cases is the ``ellipse,'' which within a short period of release flipped the major and minor axes. This behavior cannot be captured by current theoretical methods (such as the Box Model). These cases have also been investigated using shallow water and direct numerical simulations. Also, in this study, we investigate the possibility of a Rayleigh-Taylor (RT) instability of the radially moving, but decelerating front. We present a simple theoretical framework based on the inviscid Shallow Water Equations. The theoretical results are supplemented and compared to highly resolved three-dimensional simulations with the Boussinesq approximation. Chateaubriand Fellowship - NSF PIRE grant OISE-0968313.

Edge profiles in K shell photoabsorption spectra of gaseous hydrides of 3p elements and homologues

NASA Astrophysics Data System (ADS)

Hauko, R.; Gomilšek, J. Padežnik; Kodre, A.; Arčon, I.; Aquilanti, G.

2017-10-01

Photoabsorption spectra of gaseous hydrides of 3p elements (PH3, H2S, HCl) are measured in the energy region of photoexcitations pertaining to K edge. The analysis of the edge profile is extended to hydrides of 4p series (GeH4, AsH3, H2Se, HBr) from an earlier experiment, and to published spectra of 2p hydrides (CH4, NH3, H2O, HF) and noble gases Ar, Kr and Ne and SiH4. The edge profiles are modelled with a linear combination of lorentzian components, describing excitations to individual bound states and to continuum. Transition energies and probabilities are also calculated in the non-relativistic molecular model of the ORCA code, in good agreement with the experiment. Edge profiles in the heavier homologues are closely similar, the symmetry of the molecule governs the transitions to the lowest unoccupied orbitals. In 2p series the effect of the strong nuclear potential prevails. Transitions to higher, atomic-like levels remain very much the same as in free atoms.

Unsteady aerodynamic analysis of space shuttle vehicles. Part 4: Effect of control deflections on orbiter unsteady aerodynamics

NASA Technical Reports Server (NTRS)

Reding, J. P.; Ericsson, L. E.

1973-01-01

The unsteady aerodynamics of the 040A orbiter have been explored experimentally. The results substantiate earlier predictions of the unsteady flow boundaries for a 60 deg swept delta wing at zero yaw and with no controls deflected. The test revealed a previously unknown region of discontinuous yaw characteristics at transonic speeds. Oilflow results indicate that this is the result of a coupling between wing and fuselage flows via the separated region forward of the deflected elevon. In fact, the large leeward elevon deflections are shown to produce a multitude of nonlinear stability effects which sometimes involve hysteresis. Predictions of the unsteady flow boundaries are made for the current orbiter. They should carry a good degree of confidence due to the present substantiation of previous predictions for the 040A. It is proposed that the present experiments be extended to the current configuration to define control-induced effects. Every effort should be made to account for Reynolds number, roughness, and possible hot-wall effects on any future experiments.

Using Gaussian windows to explore a multivariate data set

NASA Technical Reports Server (NTRS)

Jaeckel, Louis A.

1991-01-01

In an earlier paper, I recounted an exploratory analysis, using Gaussian windows, of a data set derived from the Infrared Astronomical Satellite. Here, my goals are to develop strategies for finding structural features in a data set in a many-dimensional space, and to find ways to describe the shape of such a data set. After a brief review of Gaussian windows, I describe the current implementation of the method. I give some ways of describing features that we might find in the data, such as clusters and saddle points, and also extended structures such as a 'bar', which is an essentially one-dimensional concentration of data points. I then define a distance function, which I use to determine which data points are 'associated' with a feature. Data points not associated with any feature are called 'outliers'. I then explore the data set, giving the strategies that I used and quantitative descriptions of the features that I found, including clusters, bars, and a saddle point. I tried to use strategies and procedures that could, in principle, be used in any number of dimensions.

Heat Transfer on a Film-Cooled Blade - Effect of Hole Physics

NASA Technical Reports Server (NTRS)

Garg, Vijay K.; Rigby, David L.

1998-01-01

A multi-block, three-dimensional Navier-Stokes code has been used to study the within-hole and near-hole physics in relation to heat transfer on a film-cooled blade. The flow domain consists of the coolant flow through the plenum and hole-pipes for the three staggered rows of shower-head holes on the VK1 rotor, and the main flow over the blade. A multi-block grid is generated that is nearly orthogonal to the various surfaces. It may be noted that for the VK1 rotor the shower-head holes are inclined at 30 deg. to the spanwise direction, and are normal to the streamwise direction on the blade. Wilcox's k-omega turbulence model is used. The present study provides a much better comparison for the heat transfer coefficient at the blade mid-span with the experimental data than an earlier analysis wherein coolant velocity and temperature distributions were specified at the hole exits rather than extending the computational domain into the hole-pipe and plenum. Details of the distributions of coolant velocity, temperature, k and omega at the hole exits are also presented.

Resolving the Large Scale Spectral Variability of the Luminous Seyfert 1 Galaxy 1H 0419-577

NASA Technical Reports Server (NTRS)

Pounds, K. A.; Reeves, J. N.; Page, K. L.; OBrien, P. T.

2004-01-01

An XMM-Newton observation of the luminous Seyfert 1 galaxy 1H 0419-577 in September 2002, when the source was in an extreme low-flux state, found a very hard X-ray spectrum at 1-10 keV with a strong soft excess below approximately 1 keV. Comparison with an earlier XMM-Newton observation when 1H 0419-577 was X-ray bright indicated the dominant spectral variability was due to a steep power law or cool Comptonized thermal emission. Four further XMM-Newton observations, with 1H 0419-577 in intermediate flux states, now support that conclusion, while we also find the variable emission component in intermediate state difference spectra to be strongly modified by absorption in low ionisation matter. The variable soft excess is seen to be an artefact of absorption of the underlying continuum while the core soft emission is attributed to recombination in an extended region of more highly ionised gas. This new analysis underlines the importance of fully accounting for absorption in characterizing AGN X-ray spectra.

CFD analysis on control of secondary losses in STME LOX turbines with endwall fences

NASA Technical Reports Server (NTRS)

Chyu, Mingking K.

1992-01-01

The rotor blade in the newly designed LOX turbine for the future Space Transportation Main Engine (STME) has a severe flow turning angle, nearly 160 degrees. The estimated secondary loss in the rotor alone accounts for nearly 50 percent of the total loss over the entire stage. To reduce such a loss, one of the potential methods is to use fences attached on the turbine endwall (hub). As a prelude to examining the effects of endwall fence with actual STME turbine configuration, the present study focuses on similar issues with a different, but more generic, geometry - a rectangular duct with a 160-degree bend. The duct cross-section has a 2-to-1 aspect ratio and the radii of curvature for the inner and outer wall are 0.25 and 1.25 times the duct width, respectively. The present emphasis lies in examining the effects of various fence-length extending along the streamwise direction. The flowfield is numerically simulated using the FDNS code developed earlier by Wang and Chen. The FDNS code is a pressure based, finite-difference, Navier-Stokes equations solver.

High harmonic emission from a superposition of multiple unrelated frequency fields.

PubMed

Siegel, T; Torres, R; Hoffmann, D J; Brugnera, L; Procino, I; Zaïr, A; Underwood, Jonathan G; Springate, E; Turcu, I C E; Chipperfield, L E; Marangos, J P

2010-03-29

We report observations and analysis of high harmonic generation driven by a superposition of fields at 1290 nm and 780 nm. These fields are not commensurate in frequency and the superposition leads to an increase in the yield of the mid-plateau harmonics of more than two orders of magnitude compared to using the 1290 nm field alone. Significant extension of the cut-off photon energy is seen even by adding only a small amount of the 780 nm field. These observations are explained by calculations performed in the strong field approximation. Most importantly we find that enhancement is found to arise as a consequence of both increased ionization in the sum-field and modification of the electron trajectories leading to an earlier return time. The enhanced yield even when using modest intensity fields of 5 x 10(13) Wcm(-2) is extended to the 80 eV range and is a promising route to provide a greater photon number for applications in XUV imaging and time-resolved experiments at a high repetition rate.

Microphysical Characteristics of Clouds During the TRMM Field Campaign

NASA Technical Reports Server (NTRS)

Stith, Jeffrey L.

2003-01-01

Further analysis of the TRMM field campaign data was conducted to examine the growth of precipitation in updraft regions of the TRMM field campaign tropical clouds and to extend the earlier results to cover the whole TRMM data set collected by the University of North Dakota (UND). The results have been submitted for publication. In this paper, composite vertical profiles of liquid water, small particle concentration, and updraft/downdraft magnitudes were presented from each of the campaigns. They exhibited similar peak values for the two TRMM regions of LBA and Kwajalein. Updrafts were found to be favored locations for precipitation embryos in the form of liquid or frozen drizzle-sized droplets. Although liquid water concentrations decreased to undetectable levels between -5 and -18 C in most glaciating updrafts, occasional traces of liquid water were found in updrafts at colder temperatures, probably due to the persistence of liquid drizzle droplets. The updraft magnitudes where the traces of liquid water were observed at cold temperatures do not appear to be stronger than updrafts without liquid water at similar temperatures, however.

Analysis of high-throughput biological data using their rank values.

PubMed

Dembélé, Doulaye

2018-01-01

High-throughput biological technologies are routinely used to generate gene expression profiling or cytogenetics data. To achieve high performance, methods available in the literature become more specialized and often require high computational resources. Here, we propose a new versatile method based on the data-ordering rank values. We use linear algebra, the Perron-Frobenius theorem and also extend a method presented earlier for searching differentially expressed genes for the detection of recurrent copy number aberration. A result derived from the proposed method is a one-sample Student's t-test based on rank values. The proposed method is to our knowledge the only that applies to gene expression profiling and to cytogenetics data sets. This new method is fast, deterministic, and requires a low computational load. Probabilities are associated with genes to allow a statistically significant subset selection in the data set. Stability scores are also introduced as quality parameters. The performance and comparative analyses were carried out using real data sets. The proposed method can be accessed through an R package available from the CRAN (Comprehensive R Archive Network) website: https://cran.r-project.org/web/packages/fcros .

Numerical simulation of systems of shear bands in ductile metal with inclusions

NASA Astrophysics Data System (ADS)

Plohr, Jeeyeon

2017-06-01

We develop a method for numerical simulations of high strain-rate loading of mesoscale samples of ductile metal with inclusions. Because of its small-scale inhomogeneity, the composite material is prone to localized shear deformation. This method employs the Generalized Method of Cells to ensure that the micro mechanical behavior of the metal and inclusions is reflected properly in the behavior of the composite at the mesoscale. To find the effective plastic strain rate when shear bands are present, we extend and apply the analytic and numerical analysis of shear bands of Glimm, Plohr, and Sharp. Our tests of the method focus on the stress/strain response in uniaxial-strain flow, both compressive and tensile, of depleted uranium metal containing silicon carbide inclusions. In results, we verify the elevated temperature and thermal softening at shear bands in our simulations of pure DU and DU/SiC composites. We also note that in composites, due the asymmetry caused by the inclusions, shear band form at different times in different subcells. In particular, in the subcells near inclusions, shear band form much earlier than they do in pure DU.

Identification of literary movements using complex networks to represent texts

NASA Astrophysics Data System (ADS)

Amancio, Diego Raphael; Oliveira, Osvaldo N., Jr.; da Fontoura Costa, Luciano

2012-04-01

The use of statistical methods to analyze large databases of text has been useful in unveiling patterns of human behavior and establishing historical links between cultures and languages. In this study, we identified literary movements by treating books published from 1590 to 1922 as complex networks, whose metrics were analyzed with multivariate techniques to generate six clusters of books. The latter correspond to time periods coinciding with relevant literary movements over the last five centuries. The most important factor contributing to the distinctions between different literary styles was the average shortest path length, in particular the asymmetry of its distribution. Furthermore, over time there has emerged a trend toward larger average shortest path lengths, which is correlated with increased syntactic complexity, and a more uniform use of the words reflected in a smaller power-law coefficient for the distribution of word frequency. Changes in literary style were also found to be driven by opposition to earlier writing styles, as revealed by the analysis performed with geometrical concepts. The approaches adopted here are generic and may be extended to analyze a number of features of languages and cultures.

Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models.

PubMed

Eaton, Jeffrey W; Menzies, Nicolas A; Stover, John; Cambiano, Valentina; Chindelevitch, Leonid; Cori, Anne; Hontelez, Jan A C; Humair, Salal; Kerr, Cliff C; Klein, Daniel J; Mishra, Sharmistha; Mitchell, Kate M; Nichols, Brooke E; Vickerman, Peter; Bakker, Roel; Bärnighausen, Till; Bershteyn, Anna; Bloom, David E; Boily, Marie-Claude; Chang, Stewart T; Cohen, Ted; Dodd, Peter J; Fraser, Christophe; Gopalappa, Chaitra; Lundgren, Jens; Martin, Natasha K; Mikkelsen, Evelinn; Mountain, Elisa; Pham, Quang D; Pickles, Michael; Phillips, Andrew; Platt, Lucy; Pretorius, Carel; Prudden, Holly J; Salomon, Joshua A; van de Vijver, David A M C; de Vlas, Sake J; Wagner, Bradley G; White, Richard G; Wilson, David P; Zhang, Lei; Blandford, John; Meyer-Rath, Gesine; Remme, Michelle; Revill, Paul; Sangrujee, Nalinee; Terris-Prestholt, Fern; Doherty, Meg; Shaffer, Nathan; Easterbrook, Philippa J; Hirnschall, Gottfried; Hallett, Timothy B

2013-12-10

New WHO guidelines recommend ART initiation for HIV-positive persons with CD4 cell counts ≤500 cells/µL, a higher threshold than was previously recommended. Country decision makers must consider whether to further expand ART eligibility accordingly. We used multiple independent mathematical models in four settings-South Africa, Zambia, India, and Vietnam-to evaluate the potential health impact, costs, and cost-effectiveness of different adult ART eligibility criteria under scenarios of current and expanded treatment coverage, with results projected over 20 years. Analyses considered extending eligibility to include individuals with CD4 ≤500 cells/µL or all HIV-positive adults, compared to the previous recommendation of initiation with CD4 ≤350 cells/µL. We assessed costs from a health system perspective, and calculated the incremental cost per DALY averted ($/DALY) to compare competing strategies. Strategies were considered 'very cost-effective' if the $/DALY was less than the country's per capita gross domestic product (GDP; South Africa: $8040, Zambia: $1425, India: $1489, Vietnam: $1407) and 'cost-effective' if $/DALY was less than three times per capita GDP. In South Africa, the cost per DALY averted of extending ART eligibility to CD4 ≤500 cells/µL ranged from $237 to $1691/DALY compared to 2010 guidelines; in Zambia, expanded eligibility ranged from improving health outcomes while reducing costs (i.e. dominating current guidelines) to $749/DALY. Results were similar in scenarios with substantially expanded treatment access and for expanding eligibility to all HIV-positive adults. Expanding treatment coverage in the general population was therefore found to be cost-effective. In India, eligibility for all HIV-positive persons ranged from $131 to $241/DALY and in Vietnam eligibility for CD4 ≤500 cells/µL cost $290/DALY. In concentrated epidemics, expanded access among key populations was also cost-effective. Earlier ART eligibility is estimated to be very cost-effective in low- and middle-income settings, although these questions should be revisited as further information becomes available. Scaling-up ART should be considered among other high-priority health interventions competing for health budgets. The Bill and Melinda Gates Foundation and World Health Organization.

Functional Brain Networks Develop from a “Local to Distributed” Organization

PubMed Central

Power, Jonathan D.; Dosenbach, Nico U. F.; Church, Jessica A.; Miezin, Francis M.; Schlaggar, Bradley L.; Petersen, Steven E.

2009-01-01

The mature human brain is organized into a collection of specialized functional networks that flexibly interact to support various cognitive functions. Studies of development often attempt to identify the organizing principles that guide the maturation of these functional networks. In this report, we combine resting state functional connectivity MRI (rs-fcMRI), graph analysis, community detection, and spring-embedding visualization techniques to analyze four separate networks defined in earlier studies. As we have previously reported, we find, across development, a trend toward ‘segregation’ (a general decrease in correlation strength) between regions close in anatomical space and ‘integration’ (an increased correlation strength) between selected regions distant in space. The generalization of these earlier trends across multiple networks suggests that this is a general developmental principle for changes in functional connectivity that would extend to large-scale graph theoretic analyses of large-scale brain networks. Communities in children are predominantly arranged by anatomical proximity, while communities in adults predominantly reflect functional relationships, as defined from adult fMRI studies. In sum, over development, the organization of multiple functional networks shifts from a local anatomical emphasis in children to a more “distributed” architecture in young adults. We argue that this “local to distributed” developmental characterization has important implications for understanding the development of neural systems underlying cognition. Further, graph metrics (e.g., clustering coefficients and average path lengths) are similar in child and adult graphs, with both showing “small-world”-like properties, while community detection by modularity optimization reveals stable communities within the graphs that are clearly different between young children and young adults. These observations suggest that early school age children and adults both have relatively efficient systems that may solve similar information processing problems in divergent ways. PMID:19412534

Functional brain networks develop from a "local to distributed" organization.

PubMed

Fair, Damien A; Cohen, Alexander L; Power, Jonathan D; Dosenbach, Nico U F; Church, Jessica A; Miezin, Francis M; Schlaggar, Bradley L; Petersen, Steven E

2009-05-01

The mature human brain is organized into a collection of specialized functional networks that flexibly interact to support various cognitive functions. Studies of development often attempt to identify the organizing principles that guide the maturation of these functional networks. In this report, we combine resting state functional connectivity MRI (rs-fcMRI), graph analysis, community detection, and spring-embedding visualization techniques to analyze four separate networks defined in earlier studies. As we have previously reported, we find, across development, a trend toward 'segregation' (a general decrease in correlation strength) between regions close in anatomical space and 'integration' (an increased correlation strength) between selected regions distant in space. The generalization of these earlier trends across multiple networks suggests that this is a general developmental principle for changes in functional connectivity that would extend to large-scale graph theoretic analyses of large-scale brain networks. Communities in children are predominantly arranged by anatomical proximity, while communities in adults predominantly reflect functional relationships, as defined from adult fMRI studies. In sum, over development, the organization of multiple functional networks shifts from a local anatomical emphasis in children to a more "distributed" architecture in young adults. We argue that this "local to distributed" developmental characterization has important implications for understanding the development of neural systems underlying cognition. Further, graph metrics (e.g., clustering coefficients and average path lengths) are similar in child and adult graphs, with both showing "small-world"-like properties, while community detection by modularity optimization reveals stable communities within the graphs that are clearly different between young children and young adults. These observations suggest that early school age children and adults both have relatively efficient systems that may solve similar information processing problems in divergent ways.

Trends in snowfall versus rainfall in the western United States

USGS Publications Warehouse

Knowles, N.; Dettinger, M.D.; Cayan, D.R.

2006-01-01

The water resources of the western United States depend heavily on snowpack to store part of the wintertime precipitation into the drier summer months. A well-documented shift toward earlier runoff in recent decades has been attributed to 1) more precipitation falling as rain instead of snow and 2) earlier snowmelt. The present study addresses the former, documenting a regional trend toward smaller ratios of winter-total snowfall water equivalent (SFE) to winter-total precipitation (P) during the period 1949-2004. The trends toward reduce d SFE are a response to warming across the region, with the most significant reductions occurring where winter wet-day minimum temperatures, averaged over the study period, were warmer than -5??C. Most SFE reductions were associated with winter wet-day temperature increases between 0?? and +3??C over the study period. Warmings larger than this occurred mainly at sites where the mean temperatures were cool enough that the precipitation form was less susceptible to warming trends. The trends toward reduced SFE/P ratios w ere most pronounced in March regionwide and in January near the West Coast, corresponding, to widespread warming in these months. While mean temperatures in March were sufficiently high to allow the warming, trend to produce SFE/P declines across the study region, mean January temperatures were cooler. with the result that January SFE/P impacts were restricted to the lower elevations near the West Coast. Extending the analysis back to 1920 sho ws that although the trends presented here may be partially attributable to interdecadal climate variability associated with the Pacific decadal oscillation. they also appear to result from still longer-term climate shifts.

A Note on the Relationship of Temperature and Water Vapor over Oceans, as well as the Sea Surface Temperature Impact

NASA Technical Reports Server (NTRS)

Shie, C.-L.; Tao, W.-K.; Simpson, J.

2005-01-01

This note follows up on a recent study by Shie et al. (2005) and extends the investigation of the domain-averaged moisture-temperature (Q-T) relationship from the Tropics (i.e., the previous study) to the tropical Pacific, Atlantic and Indian Oceans. The Q and T data examined in this study are obtained from the GEOS-3 [Goddard Earth Observing System Version-3] global re-analysis monthly products. Similar to what was found earlier in the Tropics, Q is also found to increase with T over the entire oceanic region; however, Q increases faster with T over oceans than over the Tropics. The Q-T distribution for the Tropics is in a quasi-linear relationship, which is embedded in a global Q-T distribution that is, however, in a more complex curvilinear relationship. The Q-T distribution over the oceanic regions seems to fall within the lower bound (ie., the relatively colder and driver regime) of the tropical Q-T distribution. T over oceans is also found increasing with SST (sea surface temperature), which seemingly implies that an air mass might have gained heat more readily from a warmer ocean as compared to a colder ocean. Q is also found to increase with SST in a manner that quantitatively resembles an earlier finding by Stevens (1990). We also found that relative humidity exhibits similar behaviors for oceanic and tropical regions, respectively, i.e., it increases with both SST and T over oceans and increases with T in the Tropics (Shie et al. 2005). All these similar features found between oceanic and tropical regions seem to inform us that oceans occupy most of the Tropics and so play a key role in determining what have happened in the Tropics.

Rapid evolution of phenology during range expansion with recent climate change.

PubMed

Lustenhouwer, Nicky; Wilschut, Rutger A; Williams, Jennifer L; van der Putten, Wim H; Levine, Jonathan M

2018-02-01

Although climate warming is expected to make habitat beyond species' current cold range edge suitable for future colonization, this new habitat may present an array of biotic or abiotic conditions not experienced within the current range. Species' ability to shift their range with climate change may therefore depend on how populations evolve in response to such novel environmental conditions. However, due to the recent nature of thus far observed range expansions, the role of rapid adaptation during climate change migration is only beginning to be understood. Here, we evaluated evolution during the recent native range expansion of the annual plant Dittrichia graveolens, which is spreading northward in Europe from the Mediterranean region. We examined genetically based differentiation between core and edge populations in their phenology, a trait that is likely under selection with shorter growing seasons and greater seasonality at northern latitudes. In parallel common garden experiments at range edges in Switzerland and the Netherlands, we grew plants from Dutch, Swiss, and central and southern French populations. Population genetic analysis following RAD-sequencing of these populations supported the hypothesized central France origins of the Swiss and Dutch range edge populations. We found that in both common gardens, northern plants flowered up to 4 weeks earlier than southern plants. This differentiation in phenology extended from the core of the range to the Netherlands, a region only reached from central France over approximately the last 50 years. Fitness decreased as plants flowered later, supporting the hypothesized benefits of earlier flowering at the range edge. Our results suggest that native range expanding populations can rapidly adapt to novel environmental conditions in the expanded range, potentially promoting their ability to spread. © 2017 John Wiley & Sons Ltd.

Trends and priorities in occupational health research and knowledge transfer in Italy.

PubMed

Rondinone, Bruna Maria; Boccuni, Fabio; Iavicoli, Sergio

2010-06-01

In 2000-2001, the Italian National Institute for Occupational Safety and Prevention (ISPESL) carried out a survey to identify the research priorities in the field of occupational safety and health (OSH). The present study, carried out in 2007-2008, was a follow-up designed to (i) review the themes identified earlier, (ii) detect emerging issues linked to new risks and forms of work, and (iii) look for any shifts in focus. The survey was extended to cover not only research but also the concept of knowledge transfer. In the first round, ISPESL distributed questionnaires to the heads of both university occupational medicine departments and prevention departments in local national health units (known as ASL in Italy) asking respondents to identify OSH priority themes. In the latest survey covering both research and the need for knowledge transfer, the same experts were asked to rank the importance of the earlier-identified topics and list any emerging issues in the OSH field. The two most important themes identified were "work accidents" and "occupational carcinogenesis". In the overall sample and among ASL experts, they received the 1st and 2nd highest mean scores. The university respondents also prioritized them but in reverse order. Some of the new priority topics included: risks associated with nanotechnologies; assessment of psychosocial and organizational risks; migration and work; and cost-benefit analysis of prevention. In light of the findings, efforts are urgently needed to identify research and knowledge transfer priorities related to workers' health and safety on an international scale using a standardized method in order to obtain comparable results, avoid wasteful duplication of resources, and reduce occupational accidents and illness.

Analysis of Atmospheric Trace Constituents from High Resolution Infrared Balloon-Borne and Ground-Based Solar Absorption Spectra

NASA Technical Reports Server (NTRS)

Goldman, A.; Murcray, F. J.; Rinsland, C. P.; Blatherwick, R. D.; Murcray, F. H.; Murcray, D. G.

1991-01-01

Recent results and ongoing studies of high resolution solar absorption spectra will be presented. The analysis of these spectra is aimed at the identification and quantification of trace constituents important in atmospheric chemistry of the stratosphere and upper troposphere. Analysis of balloon-borne and ground-based spectra obtained at 0.0025/ cm covering the 700-2200/ cm interval will be presented. Results from ground-based 0.02/ cm solar spectra, from several locations such as Denver, South Pole, M. Loa, and New Zealand will also be shown. The 0.0025/ cm spectra show many new spectroscopic features. The analysis of these spectra, along with corresponding laboratory spectra, improves the spectral line parameters, and thus the accuracy of trace constituents quantification. The combination of the recent balloon flights, with earlier flights data since 1978 at 0.02/ cm resolution, provides trends analysis of several stratospheric trace species. Results for COF2, F22, SF6, and other species will be presented. Analysis of several ground-based solar spectra provides trends for HCl, HF and other species. The retrieval methods used for total column density and altitude distribution for both ground-based and balloon-borne spectra will be presented. These are extended for the analysis of the ground-based spectra to be obtained by the high resolution interferometers of the Network for Detection of Stratospheric Change (NDSC). Progress or the University of Denver studies for the NDSC will be presented. This will include intercomparison of solar spectra and trace gases retrievals obtained from simultaneous scans by the high resolution (0.0025/ cm) interferometers of BRUKER and BOMEM.

Functional Extended Redundancy Analysis

ERIC Educational Resources Information Center

Hwang, Heungsun; Suk, Hye Won; Lee, Jang-Han; Moskowitz, D. S.; Lim, Jooseop

2012-01-01

We propose a functional version of extended redundancy analysis that examines directional relationships among several sets of multivariate variables. As in extended redundancy analysis, the proposed method posits that a weighed composite of each set of exogenous variables influences a set of endogenous variables. It further considers endogenous…

BrEPS 2.0: Optimization of sequence pattern prediction for enzyme annotation.

PubMed

Dudek, Christian-Alexander; Dannheim, Henning; Schomburg, Dietmar

2017-01-01

The prediction of gene functions is crucial for a large number of different life science areas. Faster high throughput sequencing techniques generate more and larger datasets. The manual annotation by classical wet-lab experiments is not suitable for these large amounts of data. We showed earlier that the automatic sequence pattern-based BrEPS protocol, based on manually curated sequences, can be used for the prediction of enzymatic functions of genes. The growing sequence databases provide the opportunity for more reliable patterns, but are also a challenge for the implementation of automatic protocols. We reimplemented and optimized the BrEPS pattern generation to be applicable for larger datasets in an acceptable timescale. Primary improvement of the new BrEPS protocol is the enhanced data selection step. Manually curated annotations from Swiss-Prot are used as reliable source for function prediction of enzymes observed on protein level. The pool of sequences is extended by highly similar sequences from TrEMBL and SwissProt. This allows us to restrict the selection of Swiss-Prot entries, without losing the diversity of sequences needed to generate significant patterns. Additionally, a supporting pattern type was introduced by extending the patterns at semi-conserved positions with highly similar amino acids. Extended patterns have an increased complexity, increasing the chance to match more sequences, without losing the essential structural information of the pattern. To enhance the usability of the database, we introduced enzyme function prediction based on consensus EC numbers and IUBMB enzyme nomenclature. BrEPS is part of the Braunschweig Enzyme Database (BRENDA) and is available on a completely redesigned website and as download. The database can be downloaded and used with the BrEPScmd command line tool for large scale sequence analysis. The BrEPS website and downloads for the database creation tool, command line tool and database are freely accessible at http://breps.tu-bs.de.

BrEPS 2.0: Optimization of sequence pattern prediction for enzyme annotation

PubMed Central

Schomburg, Dietmar

2017-01-01

The prediction of gene functions is crucial for a large number of different life science areas. Faster high throughput sequencing techniques generate more and larger datasets. The manual annotation by classical wet-lab experiments is not suitable for these large amounts of data. We showed earlier that the automatic sequence pattern-based BrEPS protocol, based on manually curated sequences, can be used for the prediction of enzymatic functions of genes. The growing sequence databases provide the opportunity for more reliable patterns, but are also a challenge for the implementation of automatic protocols. We reimplemented and optimized the BrEPS pattern generation to be applicable for larger datasets in an acceptable timescale. Primary improvement of the new BrEPS protocol is the enhanced data selection step. Manually curated annotations from Swiss-Prot are used as reliable source for function prediction of enzymes observed on protein level. The pool of sequences is extended by highly similar sequences from TrEMBL and SwissProt. This allows us to restrict the selection of Swiss-Prot entries, without losing the diversity of sequences needed to generate significant patterns. Additionally, a supporting pattern type was introduced by extending the patterns at semi-conserved positions with highly similar amino acids. Extended patterns have an increased complexity, increasing the chance to match more sequences, without losing the essential structural information of the pattern. To enhance the usability of the database, we introduced enzyme function prediction based on consensus EC numbers and IUBMB enzyme nomenclature. BrEPS is part of the Braunschweig Enzyme Database (BRENDA) and is available on a completely redesigned website and as download. The database can be downloaded and used with the BrEPScmd command line tool for large scale sequence analysis. The BrEPS website and downloads for the database creation tool, command line tool and database are freely accessible at http://breps.tu-bs.de. PMID:28750104

Occupancy in community-level studies

USGS Publications Warehouse

MacKenzie, Darryl I.; Nichols, James; Royle, Andy; Pollock, Kenneth H.; Bailey, Larissa L.; Hines, James

2018-01-01

Another type of multi-species studies, are those focused on community-level metrics such as species richness. In this chapter we detail how some of the single-species occupancy models described in earlier chapters have been applied, or extended, for use in such studies, while accounting for imperfect detection. We highlight how Bayesian methods using MCMC are particularly useful in such settings to easily calculate relevant community-level summaries based on presence/absence data. These modeling approaches can be used to assess richness at a single point in time, or to investigate changes in the species pool over time.

Opportunity at Work Inside Victoria Crater

NASA Technical Reports Server (NTRS)

2007-01-01

NASA Mars Exploration Rover Opportunity used its front hazard-identification camera to capture this wide-angle view of its robotic arm extended to a rock in a bright-toned layer inside Victoria Crater.

The image was taken during the rover's 1,322nd Martian day, or sol (Oct. 13, 2007).

Victoria Crater has a scalloped shape of alternating alcoves and promontories around the crater's circumference. Opportunity descended into the crater two weeks earlier, within an alcove called 'Duck Bay.' Counterclockwise around the rim, just to the right of the arm in this image, is a promontory called 'Cabo Frio.'

Empirical temperature-dependent intermolecular potentials determined by data mining from crystal data

NASA Astrophysics Data System (ADS)

Hofmann, D. W. M.; Kuleshova, L. N.

2018-05-01

Modern force fields are accurate enough to describe thermal effects in molecular crystals. Here, we have extended our earlier approach to discrete force fields for various temperatures to a force field with a continuous function. For the parametrisation of the force field, we used data mining on experimental structures with the temperature as an additional descriptor. The obtained force field can be used to minimise energy at a finite temperature and for molecular dynamics with zero-K potentials. The applicability of the method has been demonstrated for the prediction of crystal density, temperature density gradients and transition temperature.

Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015

PubMed Central

Hernández, Marta; Iglesias, M Rocío; Rodríguez-Lázaro, David; Gallardo, Alejandro; Quijada, Narciso M; Miguela-Villoldo, Pedro; Campos, Maria Jorge; Píriz, Segundo; López-Orozco, Gema; de Frutos, Cristina; Sáez, José Luis; Ugarte-Ruiz, María; Domínguez, Lucas; Quesada, Alberto

2017-01-01

Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States. PMID:28797328

Charged-particle multiplicity distributions over a wide pseudorapidity range in proton-proton collisions at √{s}= 0.9, 7, and 8 TeV

NASA Astrophysics Data System (ADS)

Acharya, S.; Adamová, D.; Adolfsson, J.; Aggarwal, M. M.; AglieriRinella, G.; Agnello, M.; Agrawal, N.; Ahammed, Z.; Ahmad, N.; Ahn, S. U.; Aiola, S.; Akindinov, A.; Alam, S. N.; Alba, J. L. B.; Albuquerque, D. S. D.; Aleksandrov, D.; Alessandro, B.; AlfaroMolina, R.; Alici, A.; Alkin, A.; Alme, J.; Alt, T.; Altenkamper, L.; Altsybeev, I.; Alves GarciaPrado, C.; An, M.; Andrei, C.; Andreou, D.; Andrews, H. A.; Andronic, A.; Anguelov, V.; Anson, C.; Antičić, T.; Antinori, F.; Antonioli, P.; Anwar, R.; Aphecetche, L.; Appelshäuser, H.; Arcelli, S.; Arnaldi, R.; Arnold, O. W.; Arsene, I. C.; Arslandok, M.; Audurier, B.; Augustinus, A.; Averbeck, R.; Azmi, M. D.; Badalà, A.; Baek, Y. W.; Bagnasco, S.; Bailhache, R.; Bala, R.; Baldisseri, A.; Ball, M.; Baral, R. C.; Barbano, A. M.; Barbera, R.; Barile, F.; Barioglio, L.; Barnaföldi, G. G.; Barnby, L. S.; Barret, V.; Bartalini, P.; Barth, K.; Bartsch, E.; Basile, M.; Bastid, N.; Basu, S.; Bathen, B.; Batigne, G.; Batista Camejo, A.; Batyunya, B.; Batzing, P. C.; Bearden, I. G.; Beck, H.; Bedda, C.; Behera, N. K.; Belikov, I.; Bellini, F.; Bello Martinez, H.; Bellwied, R.; Beltran, L. G. E.; Belyaev, V.; Bencedi, G.; Beole, S.; Bercuci, A.; Berdnikov, Y.; Berenyi, D.; Bertens, R. A.; Berzano, D.; Betev, L.; Bhasin, A.; Bhat, I. R.; Bhati, A. K.; Bhattacharjee, B.; Bhom, J.; Bianchi, L.; Bianchi, N.; Bianchin, C.; Bielčík, J.; Bielčíková, J.; Bilandzic, A.; Biswas, R.; Biswas, S.; Blair, J. T.; Blau, D.; Blume, C.; Boca, G.; Bock, F.; Bogdanov, A.; Boldizsár, L.; Bombara, M.; Bonomi, G.; Bonora, M.; Book, J.; Borel, H.; Borissov, A.; Borri, M.; Botta, E.; Bourjau, C.; Braun-Munzinger, P.; Bregant, M.; Broker, T. A.; Browning, T. A.; Broz, M.; Brucken, E. J.; Bruna, E.; Bruno, G. E.; Budnikov, D.; Buesching, H.; Bufalino, S.; Buhler, P.; Buncic, P.; Busch, O.; Buthelezi, Z.; Butt, J. B.; Buxton, J. T.; Cabala, J.; Caffarri, D.; Caines, H.; Caliva, A.; Calvo Villar, E.; Camerini, P.; Capon, A. A.; Carena, F.; Carena, W.; Carnesecchi, F.; Castillo Castellanos, J.; Castro, A. J.; Casula, E. A. R.; Ceballos Sanchez, C.; Cerello, P.; Chandra, S.; Chang, B.; Chapeland, S.; Chartier, M.; Charvet, J. L.; Chattopadhyay, S.; Chattopadhyay, S.; Chauvin, A.; Cherney, M.; Cheshkov, C.; Cheynis, B.; Chibante Barroso, V.; Chinellato, D. D.; Cho, S.; Chochula, P.; Choi, K.; Chojnacki, M.; Choudhury, S.; Chowdhury, T.; Christakoglou, P.; Christensen, C. H.; Christiansen, P.; Chujo, T.; Chung, S. U.; Cicalo, C.; Cifarelli, L.; Cindolo, F.; Cleymans, J.; Colamaria, F.; Colella, D.; Collu, A.; Colocci, M.; Concas, M.; Conesa Balbastre, G.; Conesa del Valle, Z.; Connors, M. E.; Contreras, J. G.; Cormier, T. M.; Corrales Morales, Y.; Cortés Maldonado, I.; Cortese, P.; Cosentino, M. R.; Costa, F.; Costanza, S.; Crkovská, J.; Crochet, P.; Cuautle, E.; Cunqueiro, L.; Dahms, T.; Dainese, A.; Danisch, M. C.; Danu, A.; Das, D.; Das, I.; Das, S.; Dash, A.; Dash, S.; De, S.; De Caro, A.; de Cataldo, G.; de Conti, C.; de Cuveland, J.; De Falco, A.; De Gruttola, D.; De Marco, N.; De Pasquale, S.; De Souza, R. D.; Degenhardt, H. F.; Deisting, A.; Deloff, A.; Deplano, C.; Dhankher, P.; Di Bari, D.; Di Mauro, A.; Di Nezza, P.; Di Ruzza, B.; Diakonov, I.; Diaz Corchero, M. A.; Dietel, T.; Dillenseger, P.; Divià, R.; Djuvsland, Ø.; Dobrin, A.; Domenicis Gimenez, D.; Dönigus, B.; Dordic, O.; Doremalen, L. V. V.; Drozhzhova, T.; Dubey, A. K.; Dubla, A.; Ducroux, L.; Duggal, A. K.; Dupieux, P.; Ehlers, R. J.; Elia, D.; Endress, E.; Engel, H.; Epple, E.; Erazmus, B.; Erhardt, F.; Espagnon, B.; Esumi, S.; Eulisse, G.; Eum, J.; Evans, D.; Evdokimov, S.; Fabbietti, L.; Faivre, J.; Fantoni, A.; Fasel, M.; Feldkamp, L.; Feliciello, A.; Feofilov, G.; Ferencei, J.; FernándezTéllez, A.; Ferreiro, E. G.; Ferretti, A.; Festanti, A.; Feuillard, V. J. G.; Figiel, J.; Figueredo, M. A. S.; Filchagin, S.; Finogeev, D.; Fionda, F. M.; Fiore, E. M.; Floris, M.; Foertsch, S.; Foka, P.; Fokin, S.; Fragiacomo, E.; Francescon, A.; Francisco, A.; Frankenfeld, U.; Fronze, G. G.; Fuchs, U.; Furget, C.; Furs, A.; Fusco Girard, M.; Gaardhøje, J. J.; Gagliardi, M.; Gago, A. M.; Gajdosova, K.; Gallio, M.; Galvan, C. D.; Ganoti, P.; Gao, C.; Garabatos, C.; Garcia-Solis, E.; Garg, K.; Garg, P.; Gargiulo, C.; Gasik, P.; Gauger, E. F.; Gay Ducati, M. B.; Germain, M.; Ghosh, J.; Ghosh, P.; Ghosh, S. K.; Gianotti, P.; Giubellino, P.; Giubilato, P.; Gladysz-Dziadus, E.; Glässel, P.; GomézCoral, D. M.; Gomez Ramirez, A.; Gonzalez, A. S.; Gonzalez, V.; González-Zamora, P.; Gorbunov, S.; Görlich, L.; Gotovac, S.; Grabski, V.; Graczykowski, L. K.; Graham, K. L.; Greiner, L.; Grelli, A.; Grigoras, C.; Grigoriev, V.; Grigoryan, A.; Grigoryan, S.; Grion, N.; Gronefeld, J. M.; Grosa, F.; Grosse-Oetringhaus, J. F.; Grosso, R.; Gruber, L.; Guber, F.; Guernane, R.; Guerzoni, B.; Gulbrandsen, K.; Gunji, T.; Gupta, A.; Gupta, R.; Guzman, I. B.; Haake, R.; Hadjidakis, C.; Hamagaki, H.; Hamar, G.; Hamon, J. C.; Harris, J. W.; Harton, A.; Hasan, H.; Hatzifotiadou, D.; Hayashi, S.; Heckel, S. T.; Hellbär, E.; Helstrup, H.; Herghelegiu, A.; HerreraCorral, G.; Herrmann, F.; Hess, B. A.; Hetland, K. F.; Hillemanns, H.; Hills, C.; Hippolyte, B.; Hladky, J.; Hohlweger, B.; Horak, D.; Hornung, S.; Hosokawa, R.; Hristov, P.; Hughes, C.; Humanic, T. J.; Hussain, N.; Hussain, T.; Hutter, D.; Hwang, D. S.; Iga Buitron, S. A.; Ilkaev, R.; Inaba, M.; Ippolitov, M.; Irfan, M.; Isakov, V.; Ivanov, M.; Ivanov, V.; Izucheev, V.; Jacak, B.; Jacazio, N.; Jachołkowski, A.; Jacobs, P. M.; Jadhav, M. B.; Jadlovska, S.; Jadlovsky, J.; Jaelani, S.; Jahnke, C.; Jakubowska, M. J.; Janik, M. A.; Jayarathna, P. H. S. Y.; Jena, C.; Jena, S.; Jeric, M.; Jimenez Bustamante, R. T.; Jones, P. G.; Jusko, A.; Kalinak, P.; Kalweit, A.; Kang, J. H.; Kaplin, V.; Kar, S.; Karasu Uysal, A.; Karavichev, O.; Karavicheva, T.; Karayan, L.; Karpechev, E.; Kebschull, U.; Keidel, R.; Keijdener, D. L. D.; Keil, M.; Ketzer, B.; Khan, P.; Khan, S. A.; Khanzadeev, A.; Kharlov, Y.; Khatun, A.; Khuntia, A.; Kielbowicz, M. M.; Kileng, B.; Kim, D.; Kim, D. W.; Kim, D. J.; Kim, H.; Kim, J. S.; Kim, J.; Kim, M.; Kim, M.; Kim, S.; Kim, T.; Kirsch, S.; Kisel, I.; Kiselev, S.; Kisiel, A.; Kiss, G.; Klay, J. L.; Klein, C.; Klein, J.; Klein-Bösing, C.; Klewin, S.; Kluge, A.; Knichel, M. L.; Knospe, A. G.; Kobdaj, C.; Kofarago, M.; Kollegger, T.; Kolojvari, A.; Kondratiev, V.; Kondratyeva, N.; Kondratyuk, E.; Konevskikh, A.; Konyushikhin, M.; Kopcik, M.; Kour, M.; Kouzinopoulos, C.; Kovalenko, O.; Kovalenko, V.; Kowalski, M.; Koyithatta Meethaleveedu, G.; Králik, I.; Kravčáková, A.; Krivda, M.; Krizek, F.; Kryshen, E.; Krzewicki, M.; Kubera, A. M.; Kučera, V.; Kuhn, C.; Kuijer, P. G.; Kumar, A.; Kumar, J.; Kumar, L.; Kumar, S.; Kundu, S.; Kurashvili, P.; Kurepin, A.; Kurepin, A. B.; Kuryakin, A.; Kushpil, S.; Kweon, M. J.; Kwon, Y.; La Pointe, S. L.; La Rocca, P.; Lagana Fernandes, C.; Lai, Y. S.; Lakomov, I.; Langoy, R.; Lapidus, K.; Lara, C.; Lardeux, A.; Lattuca, A.; Laudi, E.; Lavicka, R.; Lazaridis, L.; Lea, R.; Leardini, L.; Lee, S.; Lehas, F.; Lehner, S.; Lehrbach, J.; Lemmon, R. C.; Lenti, V.; Leogrande, E.; León Monzón, I.; Lévai, P.; Li, S.; Li, X.; Lien, J.; Lietava, R.; Lim, B.; Lindal, S.; Lindenstruth, V.; Lindsay, S. W.; Lippmann, C.; Lisa, M. A.; Litichevskyi, V.; Ljunggren, H. M.; Llope, W. J.; Lodato, D. F.; Loenne, P. I.; Loginov, V.; Loizides, C.; Loncar, P.; Lopez, X.; López Torres, E.; Lowe, A.; Luettig, P.; Lunardon, M.; Luparello, G.; Lupi, M.; Lutz, T. H.; Maevskaya, A.; Mager, M.; Mahajan, S.; Mahmood, S. M.; Maire, A.; Majka, R. D.; Malaev, M.; Malinina, L.; Mal'Kevich, D.; Malzacher, P.; Mamonov, A.; Manko, V.; Manso, F.; Manzari, V.; Mao, Y.; Marchisone, M.; Mareš, J.; Margagliotti, G. V.; Margotti, A.; Margutti, J.; Marín, A.; Markert, C.; Marquard, M.; Martin, N. A.; Martinengo, P.; Martinez, J. A. L.; Martínez, M. I.; Martínez García, G.; Martinez Pedreira, M.; Mas, A.; Masciocchi, S.; Masera, M.; Masoni, A.; Masson, E.; Mastroserio, A.; Mathis, A. M.; Matyja, A.; Mayer, C.; Mazer, J.; Mazzilli, M.; Mazzoni, M. A.; Meddi, F.; Melikyan, Y.; Menchaca-Rocha, A.; Meninno, E.; Mercado Pérez, J.; Meres, M.; Mhlanga, S.; Miake, Y.; Mieskolainen, M. M.; Mihaylov, D.; Mihaylov, D. L.; Milano, L.; Milosevic, J.; Mischke, A.; Mishra, A. N.; Miśkowiec, D.; Mitra, J.; Mitu, C. M.; Mohammadi, N.; Mohanty, B.; Mohisin Khan, M.; Montes, E.; Moreira De Godoy, D. A.; Moreno, L. A. P.; Moretto, S.; Morreale, A.; Morsch, A.; Muccifora, V.; Mudnic, E.; Mühlheim, D.; Muhuri, S.; Mukherjee, M.; Mulligan, J. D.; Munhoz, M. G.; Münning, K.; Munzer, R. H.; Murakami, H.; Murray, S.; Musa, L.; Musinsky, J.; Myers, C. J.; Myrcha, J. W.; Naik, B.; Nair, R.; Nandi, B. K.; Nania, R.; Nappi, E.; Narayan, A.; Naru, M. U.; Natal daLuz, H.; Nattrass, C.; Navarro, S. R.; Nayak, K.; Nayak, R.; Nayak, T. K.; Nazarenko, S.; Nedosekin, A.; Negrao De Oliveira, R. A.; Nellen, L.; Nesbo, S. V.; Ng, F.; Nicassio, M.; Niculescu, M.; Niedziela, J.; Nielsen, B. S.; Nikolaev, S.; Nikulin, S.; Nikulin, V.; Nobuhiro, A.; Noferini, F.; Nomokonov, P.; Nooren, G.; Noris, J. C. C.; Norman, J.; Nyanin, A.; Nystrand, J.; Oeschler, H.; Oh, S.; Ohlson, A.; Okubo, T.; Olah, L.; Oleniacz, J.; Oliveira Da Silva, A. C.; Oliver, M. H.; Onderwaater, J.; Oppedisano, C.; Orava, R.; Oravec, M.; Ortiz Velasquez, A.; Oskarsson, A.; Otwinowski, J.; Oyama, K.; Pachmayer, Y.; Pacik, V.; Pagano, D.; Pagano, P.; Paić, G.; Palni, P.; Pan, J.; Pandey, A. K.; Panebianco, S.; Papikyan, V.; Pappalardo, G. S.; Pareek, P.; Park, J.; Parmar, S.; Passfeld, A.; Pathak, S. P.; Paticchio, V.; Patra, R. N.; Paul, B.; Pei, H.; Peitzmann, T.; Peng, X.; Pereira, L. G.; Pereira Da Costa, H.; Peresunko, D.; Perez Lezama, E.; Peskov, V.; Pestov, Y.; Petráček, V.; Petrov, V.; Petrovici, M.; Petta, C.; Pezzi, R. P.; Piano, S.; Pikna, M.; Pillot, P.; Pimentel, L. O. D. L.; Pinazza, O.; Pinsky, L.; Piyarathna, D. B.; Płoskoń, M.; Planinic, M.; Pliquett, F.; Pluta, J.; Pochybova, S.; Podesta-Lerma, P. L. M.; Poghosyan, M. G.; Polichtchouk, B.; Poljak, N.; Poonsawat, W.; Pop, A.; Poppenborg, H.; Porteboeuf-Houssais, S.; Porter, J.; Pozdniakov, V.; Prasad, S. K.; Preghenella, R.; Prino, F.; Pruneau, C. A.; Pshenichnov, I.; Puccio, M.; Puddu, G.; Pujahari, P.; Punin, V.; Putschke, J.; Rachevski, A.; Raha, S.; Rajput, S.; Rak, J.; Rakotozafindrabe, A.; Ramello, L.; Rami, F.; Rana, D. B.; Raniwala, R.; Raniwala, S.; Räsänen, S. S.; Rascanu, B. T.; Rathee, D.; Ratza, V.; Ravasenga, I.; Read, K. F.; Redlich, K.; Rehman, A.; Reichelt, P.; Reidt, F.; Ren, X.; Renfordt, R.; Reolon, A. R.; Reshetin, A.; Reygers, K.; Riabov, V.; Ricci, R. A.; Richert, T.; Richter, M.; Riedler, P.; Riegler, W.; Riggi, F.; Ristea, C.; Rodríguez Cahuantzi, M.; Røed, K.; Rogochaya, E.; Rohr, D.; Röhrich, D.; Rokita, P. S.; Ronchetti, F.; Rosnet, P.; Rossi, A.; Rotondi, A.; Roukoutakis, F.; Roy, A.; Roy, C.; Roy, P.; Rubio Montero, A. J.; Rueda, O. V.; Rui, R.; Russo, R.; Rustamov, A.; Ryabinkin, E.; Ryabov, Y.; Rybicki, A.; Saarinen, S.; Sadhu, S.; Sadovsky, S.; Šafařík, K.; Saha, S. K.; Sahlmuller, B.; Sahoo, B.; Sahoo, P.; Sahoo, R.; Sahoo, S.; Sahu, P. K.; Saini, J.; Sakai, S.; Saleh, M. A.; Salzwedel, J.; Sambyal, S.; Samsonov, V.; Sandoval, A.; Sarkar, D.; Sarkar, N.; Sarma, P.; Sas, M. H. P.; Scapparone, E.; Scarlassara, F.; Scharenberg, R. P.; Scheid, H. S.; Schiaua, C.; Schicker, R.; Schmidt, C.; Schmidt, H. R.; Schmidt, M. O.; Schmidt, M.; Schuchmann, S.; Schukraft, J.; Schutz, Y.; Schwarz, K.; Schweda, K.; Scioli, G.; Scomparin, E.; Scott, R.; Šefčík, M.; Seger, J. E.; Sekiguchi, Y.; Sekihata, D.; Selyuzhenkov, I.; Senosi, K.; Senyukov, S.; Serradilla, E.; Sett, P.; Sevcenco, A.; Shabanov, A.; Shabetai, A.; Shahoyan, R.; Shaikh, W.; Shangaraev, A.; Sharma, A.; Sharma, A.; Sharma, M.; Sharma, M.; Sharma, N.; Sheikh, A. I.; Shigaki, K.; Shou, Q.; Shtejer, K.; Sibiriak, Y.; Siddhanta, S.; Sielewicz, K. M.; Siemiarczuk, T.; Silvermyr, D.; Silvestre, C.; Simatovic, G.; Simonetti, G.; Singaraju, R.; Singh, R.; Singhal, V.; Sinha, T.; Sitar, B.; Sitta, M.; Skaali, T. B.; Slupecki, M.; Smirnov, N.; Snellings, R. J. M.; Snellman, T. W.; Song, J.; Song, M.; Soramel, F.; Sorensen, S.; Sozzi, F.; Spiriti, E.; Sputowska, I.; Srivastava, B. K.; Stachel, J.; Stan, I.; Stankus, P.; Stenlund, E.; Stocco, D.; Strmen, P.; Suaide, A. A. P.; Sugitate, T.; Suire, C.; Suleymanov, M.; Suljic, M.; Sultanov, R.; Šumbera, M.; Sumowidagdo, S.; Suzuki, K.; Swain, S.; Szabo, A.; Szarka, I.; Szczepankiewicz, A.; Tabassam, U.; Takahashi, J.; Tambave, G. J.; Tanaka, N.; Tarhini, M.; Tariq, M.; Tarzila, M. G.; Tauro, A.; Tejeda Muñoz, G.; Telesca, A.; Terasaki, K.; Terrevoli, C.; Teyssier, B.; Thakur, D.; Thakur, S.; Thomas, D.; Tieulent, R.; Tikhonov, A.; Timmins, A. R.; Toia, A.; Tripathy, S.; Trogolo, S.; Trombetta, G.; Tropp, L.; Trubnikov, V.; Trzaska, W. H.; Trzeciak, B. A.; Tsuji, T.; Tumkin, A.; Turrisi, R.; Tveter, T. S.; Ullaland, K.; Umaka, E. N.; Uras, A.; Usai, G. L.; Utrobicic, A.; Vala, M.; Van Der Maarel, J.; Van Hoorne, J. W.; van Leeuwen, M.; Vanat, T.; Vande Vyvre, P.; Varga, D.; Vargas, A.; Vargyas, M.; Varma, R.; Vasileiou, M.; Vasiliev, A.; Vauthier, A.; Vázquez Doce, O.; Vechernin, V.; Veen, A. M.; Velure, A.; Vercellin, E.; Vergara Limón, S.; Vernet, R.; Vértesi, R.; Vickovic, L.; Vigolo, S.; Viinikainen, J.; Vilakazi, Z.; Villalobos Baillie, O.; Villatoro Tello, A.; Vinogradov, A.; Vinogradov, L.; Virgili, T.; Vislavicius, V.; Vodopyanov, A.; Völkl, M. A.; Voloshin, K.; Voloshin, S. A.; Volpe, G.; von Haller, B.; Vorobyev, I.; Voscek, D.; Vranic, D.; Vrláková, J.; Wagner, B.; Wagner, J.; Wang, H.; Wang, M.; Watanabe, D.; Watanabe, Y.; Weber, M.; Weber, S. G.; Weiser, D. F.; Wenzel, S. C.; Wessels, J. P.; Westerhoff, U.; Whitehead, A. M.; Wiechula, J.; Wikne, J.; Wilk, G.; Wilkinson, J.; Willems, G. A.; Williams, M. C. S.; Willsher, E.; Windelband, B.; Witt, W. E.; Yalcin, S.; Yamakawa, K.; Yang, P.; Yano, S.; Yin, Z.; Yokoyama, H.; Yoo, I.-K.; Yoon, J. H.; Yurchenko, V.; Zaccolo, V.; Zaman, A.; Zampolli, C.; Zanoli, H. J. C.; Zardoshti, N.; Zarochentsev, A.; Závada, P.; Zaviyalov, N.; Zbroszczyk, H.; Zhalov, M.; Zhang, H.; Zhang, X.; Zhang, Y.; Zhang, C.; Zhang, Z.; Zhao, C.; Zhigareva, N.; Zhou, D.; Zhou, Y.; Zhou, Z.; Zhu, H.; Zhu, J.; Zhu, X.; Zichichi, A.; Zimmermann, A.; Zimmermann, M. B.; Zinovjev, G.; Zmeskal, J.; Zou, S.

2017-12-01

We present the charged-particle multiplicity distributions over a wide pseudorapidity range (- 3.4<η <5.0) for pp collisions at √{s}= 0.9, 7, and 8 TeV at the LHC. Results are based on information from the Silicon Pixel Detector and the Forward Multiplicity Detector of ALICE, extending the pseudorapidity coverage of the earlier publications and the high-multiplicity reach. The measurements are compared to results from the CMS experiment and to PYTHIA, PHOJET and EPOS LHC event generators, as well as IP-Glasma calculations.

Stochastic solution to quantum dynamics

NASA Technical Reports Server (NTRS)

John, Sarah; Wilson, John W.

1994-01-01

The quantum Liouville equation in the Wigner representation is solved numerically by using Monte Carlo methods. For incremental time steps, the propagation is implemented as a classical evolution in phase space modified by a quantum correction. The correction, which is a momentum jump function, is simulated in the quasi-classical approximation via a stochastic process. The technique, which is developed and validated in two- and three- dimensional momentum space, extends an earlier one-dimensional work. Also, by developing a new algorithm, the application to bound state motion in an anharmonic quartic potential shows better agreement with exact solutions in two-dimensional phase space.

Storming ahead

NASA Astrophysics Data System (ADS)

Showstack, Randy

Fourteen tropical storms, nine hurricanes, and four intense hurricanes with winds above 111 mph. That's the forecast for hurricane activity in the Atlantic Basin for the upcoming hurricane season which extends from June 1 through November 30, 1999, according to a Colorado State Hurricane Forecast team led by William Gray, professor of atmospheric science. The forecast supports an earlier report by the team.Hurricane activity, said Gray will be similar to 1998—which yielded 14 tropical storms, 10 hurricanes, and 3 intense storms. These numbers are significantly higher than the long-term statistical averages of 9.3, 5.8, and 2.2, annually.

Oscillating and static universes from a single barotropic fluid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kehayias, John; Scherrer, Robert J.

We consider cosmological solutions to general relativity with a single barotropic fluid, where the pressure is a general function of the density, p=f(ρ). We derive conditions for static and oscillating solutions and provide examples, extending earlier work to these simpler and more general single-fluid cosmologies. Generically we expect such solutions to suffer from instabilities, through effects such as quantum fluctuations or tunneling to zero size. We also find a classical instability (“no-go” theorem) for oscillating solutions of a single barotropic perfect fluid due to a necessarily negative squared sound speed.

Oscillating and static universes from a single barotropic fluid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kehayias, John; Scherrer, Robert J., E-mail: john.kehayias@vanderbilt.edu, E-mail: robert.scherrer@vanderbilt.edu

We consider cosmological solutions to general relativity with a single barotropic fluid, where the pressure is a general function of the density, p = f(ρ). We derive conditions for static and oscillating solutions and provide examples, extending earlier work to these simpler and more general single-fluid cosmologies. Generically we expect such solutions to suffer from instabilities, through effects such as quantum fluctuations or tunneling to zero size. We also find a classical instability (''no-go'' theorem) for oscillating solutions of a single barotropic perfect fluid due to a necessarily negative squared sound speed.

Anticipating Economic Market Crises Using Measures of Collective Panic

PubMed Central

2015-01-01

Predicting panic is of critical importance in many areas of human and animal behavior, notably in the context of economics. The recent financial crisis is a case in point. Panic may be due to a specific external threat or self-generated nervousness. Here we show that the recent economic crisis and earlier large single-day panics were preceded by extended periods of high levels of market mimicry—direct evidence of uncertainty and nervousness, and of the comparatively weak influence of external news. High levels of mimicry can be a quite general indicator of the potential for self-organized crises. PMID:26185988

New Parameterization of Neutron Absorption Cross Sections

NASA Technical Reports Server (NTRS)

Tripathi, Ram K.; Wilson, John W.; Cucinotta, Francis A.

1997-01-01

Recent parameterization of absorption cross sections for any system of charged ion collisions, including proton-nucleus collisions, is extended for neutron-nucleus collisions valid from approx. 1 MeV to a few GeV, thus providing a comprehensive picture of absorption cross sections for any system of collision pairs (charged or uncharged). The parameters are associated with the physics of the problem. At lower energies, optical potential at the surface is important, and the Pauli operator plays an increasingly important role at intermediate energies. The agreement between the calculated and experimental data is better than earlier published results.

Photoelectron interference fringes by super intense x-ray laser pulses

NASA Astrophysics Data System (ADS)

Toyota, Koudai; Tolstikhin, Oleg I.; Morishita, Toru; Watanabe, Shinichi

2009-09-01

The photoelectron spectra of H- produced by circularly polarized strong high-frequency laser pulses are theoretically studied. An oscillating substructure in the above-threshold ionization (ATI) peaks is observed, which extends the validity of the earlier findings in the 1D calculations [K. Toyota et al., Phys. Rev. A 76, 043418 (2007)] and 3D calculations for linear polarization [O. I. Tolstikhin, Phys. Rev. A 77, 032712 (2008)]. Its origin is due to an interference between a pair of photoelectron wave packets created in the rising and falling part of the pulse, which appears clearly in the stabilization regime.

IUS with Magellan spacecraft drifts into space after STS-30 deployment

NASA Image and Video Library

1989-05-04

STS030-71-070 (4 May 1989) --- This scene is one of two released by NASA showing the process of solar array panel deployment on the Magellan spacecraft. Though partially blended into the backdrop of the blackness of space, it appears the two panels are fully extended in this frame. The spacecraft had earlier been released by the STS-30 crewmembers to begin its long journey to the planet Venus for an extensive radar mapping mission. The frame was photographed through Atlantis' aft flight deck windows with a handheld 70mm camera. The complementary photograph is STS030-71-063.

Extended Characterization of the Common-Source and Common-Gate Amplifiers using a Metal-Ferroelectric-Semiconductor Field Effect Transistor

NASA Technical Reports Server (NTRS)

Hunt, Mitchell; Sayyah, Rana; Mitchell, Cody; Laws, Crystal; MacLeod, Todd C.; Ho, Fat D.

2013-01-01

Collected data for both common-source and common-gate amplifiers is presented in this paper. Characterizations of the two amplifier circuits using metal-ferroelectric-semiconductor field effect transistors (MFSFETs) are developed with wider input frequency ranges and varying device sizes compared to earlier characterizations. The effects of the ferroelectric layer's capacitance and variation load, quiescent point, or input signal on each circuit are discussed. Comparisons between the MFSFET and MOSFET circuit operation and performance are discussed at length as well as applications and advantages for the MFSFETs.

Computing Evans functions numerically via boundary-value problems

NASA Astrophysics Data System (ADS)

Barker, Blake; Nguyen, Rose; Sandstede, Björn; Ventura, Nathaniel; Wahl, Colin

2018-03-01

The Evans function has been used extensively to study spectral stability of travelling-wave solutions in spatially extended partial differential equations. To compute Evans functions numerically, several shooting methods have been developed. In this paper, an alternative scheme for the numerical computation of Evans functions is presented that relies on an appropriate boundary-value problem formulation. Convergence of the algorithm is proved, and several examples, including the computation of eigenvalues for a multi-dimensional problem, are given. The main advantage of the scheme proposed here compared with earlier methods is that the scheme is linear and scalable to large problems.

Estimation of the Maximum Theoretical Productivity of Fed-Batch Bioreactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bomble, Yannick J; St. John, Peter C; Crowley, Michael F

2017-10-18

A key step towards the development of an integrated biorefinery is the screening of economically viable processes, which depends sharply on the yields and productivities that can be achieved by an engineered microorganism. In this study, we extend an earlier method which used dynamic optimization to find the maximum theoretical productivity of batch cultures to explicitly include fed-batch bioreactors. In addition to optimizing the intracellular distribution of metabolites between cell growth and product formation, we calculate the optimal control trajectory of feed rate versus time. We further analyze how sensitive the productivity is to substrate uptake and growth parameters.

Lessons from Queensland's last-drinks legislation: The use of extended trading permits.

PubMed

Zahnow, Renee; Miller, Peter; Coomber, Kerri; de Andrade, Dominique; Ferris, Jason

2018-05-01

The association between alcohol availability, alcohol consumption and, in turn, alcohol-related harms is well established. Policies to reduce alcohol-related harms focus on limiting accessibility through the regulation of the liquor industry, including trading hours. On 1 July 2016, the Queensland Government introduced legislation to reduce ordinary liquor trading hours, replacing 5 am closing times with 3 am cessation of liquor sales in designated entertainment precincts and 2 am cessation of sales across the rest of the state. However, the amendment was under-inclusive and did not apply to temporary extended trading permits, a provision of the Liquor Act 1992 allowing one-off variations in trading hours for special events. We use 24 months of data (1 January 2015 to 31 December 2016) from the Office of Liquor Gaming and Regulation to explore patterns of extended trading permit use across Queensland, pre- and post- 1 July 2016. We find that following the Amendment in 2016 there was also a distinct shift in the utilisation of temporary extended trading permits, with a 63% increase in approved permits between 2015 and 2016. Temporal clustering around key calendar events dissipated following 1 July 2016 with consistent concentration of permit utilisation over consecutive weeks. Using temporary extended trading permits venue owners avoided earlier closing times and continued to operate until 5 am. The findings provide lessons for future policy implementation by illustrating the capacity for under-inclusive legislation to result in the dilution of intended effects. © 2018 Australasian Professional Society on Alcohol and other Drugs.

High Frequency Adaptive Instability Suppression Controls in a Liquid-Fueled Combustor

NASA Technical Reports Server (NTRS)

Kopasakis, George

2003-01-01

This effort extends into high frequency (>500 Hz), an earlier developed adaptive control algorithm for the suppression of thermo-acoustic instabilities in a liquidfueled combustor. The earlier work covered the development of a controls algorithm for the suppression of a low frequency (280 Hz) combustion instability based on simulations, with no hardware testing involved. The work described here includes changes to the simulation and controller design necessary to control the high frequency instability, augmentations to the control algorithm to improve its performance, and finally hardware testing and results with an experimental combustor rig developed for the high frequency case. The Adaptive Sliding Phasor Averaged Control (ASPAC) algorithm modulates the fuel flow in the combustor with a control phase that continuously slides back and forth within the phase region that reduces the amplitude of the instability. The results demonstrate the power of the method - that it can identify and suppress the instability even when the instability amplitude is buried in the noise of the combustor pressure. The successful testing of the ASPAC approach helped complete an important NASA milestone to demonstrate advanced technologies for low-emission combustors.

Current sheet formation in a sheared force-free-magnetic field. [in sun

NASA Technical Reports Server (NTRS)

Wolfson, Richard

1989-01-01

This paper presents the results of a study showing how continuous shearing motion of magnetic footpoints in a tenuous, infinitely conducting plasma can lead to the development of current sheets, despite the absence of such sheets or even of neutral points in the initial state. The calculations discussed here verify the earlier suggestion by Low and Wolfson (1988) that extended current sheets should form due to the shearing of a force-free quadrupolar magnetic field. More generally, this work augments earlier studies suggesting that the appearance of discontinuities - current sheets - may be a necessary consequence of the topological invariance imposed on the magnetic field geometry of an ideal MHD system by virtue of its infinite conductivity. In the context of solar physics, the work shows how the gradual and continuous motion of magnetic footpoints at the solar photosphere may lead to the buildup of magnetic energy that can then be released explosively when finite conductivity effects become important and lead to the rapid dissipation of current sheets. Such energy release may be important in solar flares, coronal mass ejections, and other eruptive events.

Travel Behavior Change in Older Travelers: Understanding Critical Reactions to Incidents Encountered in Public Transport.

PubMed

Sundling, Catherine

2015-11-18

Accessibility of travel may be better understood if psychological factors underlying change in travel behavior are known. This paper examines older (65+) travelers' motives for changing their travel behavior. These changes are grounded in critical incidents earlier encountered in public-transport travel. A scientific framework is developed based on cognitive and behavioral theory. In 29 individual interviews, travelers' critical reactions (i.e., cognitive, emotional, and/or behavioral) to 77 critical incidents were examined. By applying critical incident technique (CIT), five reaction themes were identified that had generated travel-behavior change: firm restrictions, unpredictability, unfair treatment, complicated trips, and earlier adverse experiences. To improve older travelers' access to public transport, key findings were: (a) service must be designed so as to strengthen the feeling of being in control throughout the journey; (b) extended personal service would increase predictability in the travel chain and decrease travel complexity; consequently, (c) when designing new services and making effective accessibility interventions, policy makers should consider and utilize underlying psychological factors that could direct traveler behavior.

Travel Behavior Change in Older Travelers: Understanding Critical Reactions to Incidents Encountered in Public Transport

PubMed Central

Sundling, Catherine

2015-01-01

Accessibility of travel may be better understood if psychological factors underlying change in travel behavior are known. This paper examines older (65+) travelers’ motives for changing their travel behavior. These changes are grounded in critical incidents earlier encountered in public-transport travel. A scientific framework is developed based on cognitive and behavioral theory. In 29 individual interviews, travelers’ critical reactions (i.e., cognitive, emotional, and/or behavioral) to 77 critical incidents were examined. By applying critical incident technique (CIT), five reaction themes were identified that had generated travel-behavior change: firm restrictions, unpredictability, unfair treatment, complicated trips, and earlier adverse experiences. To improve older travelers’ access to public transport, key findings were: (a) service must be designed so as to strengthen the feeling of being in control throughout the journey; (b) extended personal service would increase predictability in the travel chain and decrease travel complexity; consequently, (c) when designing new services and making effective accessibility interventions, policy makers should consider and utilize underlying psychological factors that could direct traveler behavior. PMID:26593935

Results of Russian geomagnetic observatories in the 19th century: magnetic activity, 1841-1862

NASA Astrophysics Data System (ADS)

Nevanlinna, H.; Häkkinen, L.

2010-04-01

Hourly (spot readings) magnetic data (H- and D-components) were digitized from Russian yearbook tables for the years 1850-1862 from four observatories. The pdf pictures for digitization were taken by a normal digital camera. The database obtained consists of about 900 000 single data points. The time series of hourly magnetic values reveal slow secular variations (declination only) as well as transient and regular geomagnetic variations of external origin. The quality and homogeneity of the data is satisfactory. Daily Ak-indices were calculated using the index algorithm that has been earlier applied to 19th century data from Helsinki (Finland) as well as modern magnetic observatory recordings. The activity index series derived from the Russian data is consistent with earlier activity index series for 1850-1862. The digitized index data series derived in this study was extended back to 1841 by including magnetic C9 activity index data available from a Russian observatory (St. Petersburg). Magnetic data rescued here is well suitable for various reconstructions for studies of the long-term variation of the space weather in the 19th century.

Addiction research centres and the nurturing of creativity. University of Michigan Addiction Research Center (UMARC): development, evolution, and direction.

PubMed

Zucker, Robert A

2010-06-01

A historical summary is provided of the evolution of the University of Michigan Addiction Research Center (UMARC) since its origins in 1988. Begun as an National Institutes of Health (NIH) research center within a Department of Psychiatry and focused solely upon alcohol and aging, early work emphasized treatment efficacy, differential outcome studies and characterization of the neurophysiological and behavioral manifestations of chronic alcoholism. Over the last 15 years, UMARC has extended its research focus along a number of dimensions: its developmental reach has been extended etiologically by studies of risk early in the life span, and by way of work on earlier screening and the development of early, brief treatment interventions. The addiction focus has expanded to include other drugs of abuse. Levels of analysis have also broadened, with work on the molecular genetics and brain neurophysiology underlying addictive processes, on one hand, and examination of the role of the social environment in long-term course of disorder on the other hand. Activities have been facilitated by several research training programs and by collaborative relationships with other universities around the United States and in Poland. Since 2002, a program for research infrastructure development and collaboration has been ongoing, initially with Poland and more recently with Ukraine, Latvia and Slovakia. A blueprint for the future includes expanded characterization of the neurobiology and genetics of addictive processes, the developmental environment, as well as programmatic work to address the public health implications of our ability to identify risk for disorder very early in life.

Addiction research centres and the nurturing of creativity: University of Michigan Addiction Research Center (UMARC): Development, Evolution, and Direction

PubMed Central

Zucker, Robert A.

2010-01-01

A historical summary is provided of the evolution of the University of Michigan Addiction Research Center (UMARC) since its origins in 1988. Begun as an NIH research center within a Department of Psychiatry and focused solely on alcohol and aging, early work emphasized treatment efficacy, differential outcome studies, and characterization of the neurophysiological and behavioral manifestations of chronic alcoholism. Over the last fifteen years, UMARC has extended its research focus along a number of dimensions: Its developmental reach has been extended etiologically by studies of risk early in the life span, and by way of work on earlier screening and the development of early, brief treatment interventions. The addiction focus has expanded to include other drugs of abuse. Levels of analysis have also broadened, with work on the molecular genetics and brain neurophysiology underlying addictive processes on the one hand, and examination of the role of the social environment in long term course of disorder on the other. Activities have been facilitated by several research training programs and by collaborative relationships with other universities around the United States and in Poland. Since 2002, a program for research infrastructure development and collaboration has been carried on, initially with Poland and more recently with Ukraine, Latvia, and Slovakia. A blueprint for the future includes expanded characterization of the neurobiology and genetics of addictive processes, the developmental environment, as well as programmatic work to address the public health implications of our ability to identify risk for disorder very early in life. PMID:20331547

Hydrologic, Hydraulic, and Flood Analyses of the Blackberry Creek Watershed, Kendall County, Illinois

USGS Publications Warehouse

Murphy, Elizabeth A.; Straub, Timothy D.; Soong, David T.; Hamblen, Christopher S.

2007-01-01

Results of the hydrologic model, flood-frequency, hydraulic model, and flood-hazard analysis of the Blackberry Creek watershed in Kendall County, Illinois, indicate that the 100-year and 500-year flood plains cover approximately 3,699 and 3,762 acres of land, respectively. On the basis of land-cover data for 2003, most of the land in the flood plains was cropland and residential land. Although many acres of residential land were included in the flood plain, this land was mostly lawns, with 25 homes within the 100-year flood plain, and 41 homes within the 500-year flood plain in the 2003 aerial photograph. This report describes the data collection activities to refine the hydrologic and hydraulic models used in an earlier study of the Kane County part of the Blackberry Creek watershed and to extend the flood-frequency analysis through water year 2003. The results of the flood-hazard analysis are presented in graphical and tabular form. The hydrologic model, Hydrological Simulation Program - FORTRAN (HSPF), was used to simulate continuous water movement through various land-use patterns in the watershed. Flood-frequency analysis was applied to an annual maximum series to determine flood quantiles in subbasins for flood-hazard analysis. The Hydrologic Engineering Center- River Analysis System (HEC-RAS) hydraulic model was used to determine the 100-year and 500-year flood elevations, and the 100-year floodway. The hydraulic model was calibrated and verified using observations during three storms at two crest-stage gages and the U.S. Geological Survey streamflowgaging station near Yorkville. Digital maps of the 100-year and 500-year flood plains and the 100-year floodway for each tributary and the main stem of Blackberry Creek were compiled.

Morphology and Composition of Localized Lunar Dark Mantle Deposits With LROC Data

NASA Astrophysics Data System (ADS)

Gustafson, O.; Bell, J. F.; Gaddis, L. R.; Hawke, B. R.; Robinson, M. S.; LROC Science Team

2010-12-01

Clementine color (ultraviolet, visible or UVVIS) and Lunar Reconnaissance Orbiter (LRO) Wide Angle (WAC) and Narrow Angle (NAC) camera data provide the means to investigate localized lunar dark-mantle deposits (DMDs) of potential pyroclastic origin. Our goals are to (1) examine the morphology and physical characteristics of these deposits with LROC WAC and NAC data; (2) extend methods used in earlier studies of lunar DMDs with Clementine spectral reflectance (CSR) data; (3) use LRO WAC multispectral data to complement and extend the CSR data for compositional analyses; and (4) apply these results to identify the likely mode of emplacement and study the diversity of compositions among these deposits. Pyroclastic deposits have been recognized all across the Moon, identified by their low albedo, smooth texture, and mantling relationship to underlying features. Gaddis et al. (2003) presented a compositional analysis of 75 potential lunar pyroclastic deposits (LPDs) based on CSR measurements. New LRO camera (LROC) data permit more extensive analyses of such deposits than previously possible. Our study began with six sites on the southeastern limb of the Moon that contain nine of the cataloged 75 potential pyroclastic deposits: Humboldt (4 deposits), Petavius, Barnard, Abel B, Abel C, and Titius. Our analysis found that some of the DMDs exhibit qualities characteristic of fluid emplacement, such as flat surfaces, sharp margins, embaying relationships, and flow textures. We conclude that the localized DMDs are a complex class of features, many of which may have formed by a combination of effusive and pyroclastic emplacement mechanisms. We have extended this analysis to include additional localized DMDs from the catalog of 75 potential pyroclastic deposits. We have examined high resolution (up to 0.5 m/p) NAC images as they become available to assess the mode of emplacement of the deposits, locate potential volcanic vents, and assess physical characteristics of the DMDs such as thickness, roughness, and rock abundance. Within and around each DMD, the Clementine UVVIS multispectral mosaic (100 m/p, 5 bands at 415, 750, 900, 950, and 1000 nm) and LROC WAC multispectral image cubes (75 to 400 m/p, 7 bands at 320, 360, 415, 565, 605, 645, and 690 nm) have been used to extract spectral reflectance data. Spectral ratio plots were prepared to compare deposits and draw conclusions regarding compositional differences, such as mafic mineral or titanium content and distribution, both within and between DMDs. The result of the study will be an improved classification of these deposits in terms of emplacement mechanisms and composition, including identifying compositional affinities among DMDs and between DMDs and other volcanic deposits.

Cohort Differences in Cognitive Aging and Terminal Decline in the Seattle Longitudinal Study

PubMed Central

Gerstorf, Denis; Ram, Nilam; Hoppmann, Christiane; Willis, Sherry L.; Schaie, K. Warner

2011-01-01

Life span researchers have long been interested in how and why fundamental aspects of human ontogeny differ between cohorts of people who have lived through different historical epochs. When examined at the same age, later born cohorts are often cognitively and physically fitter than earlier born cohorts. Less is known, however, about cohort differences in the rate of cognitive aging and if, at the very end of life, pervasive mortality-related processes overshadow and minimize cohort differences. We used data on 5 primary mental abilities from the Seattle Longitudinal Study (Schaie, 2005) to compare both age-related and mortality-related changes between earlier born cohorts (1886–1913) and later born cohorts (1914–1948). Our models covary for several individual and cohort differences in central indicators of life expectancy, education, health, and gender. Age-related growth models corroborate and extend earlier findings by documenting level differences at age 70 of up to 0.50 SD and less steep rates of cognitive aging on all abilities between 50 and 80 years of age favoring the later born cohort. In contrast, mortality-related models provide limited support for positive cohort differences. The later born cohort showed steeper mortality-related declines. We discuss possible reasons why often reported positive secular trends in age-related processes may not generalize to the vulnerable segment of the population that is close to death and suggest routes for further inquiry. PMID:21517155

Structure of weakly 2-dependent siphons

NASA Astrophysics Data System (ADS)

Chao, Daniel Yuh; Chen, Jiun-Ting

2013-09-01

Deadlocks arising from insufficiently marked siphons in flexible manufacturing systems can be controlled by adding monitors to each siphon - too many for large systems. Li and Zhou add monitors to elementary siphons only while controlling the rest of (called dependent) siphons by adjusting control depth variables of elementary siphons. Only a linear number of monitors are required. The control of weakly dependent siphons (WDSs) is rather conservative since only positive terms were considered. The structure for strongly dependent siphons (SDSs) has been studied earlier. Based on this structure, the optimal sequence of adding monitors has been discovered earlier. Better controllability has been discovered to achieve faster and more permissive control. The results have been extended earlier to S3PGR2 (systems of simple sequential processes with general resource requirements). This paper explores the structures for WDSs, which, as found in this paper, involve elementary resource circuits interconnecting at more than (for SDSs, exactly) one resource place. This saves the time to compute compound siphons, their complementary sets and T-characteristic vectors. Also it allows us (1) to improve the controllability of WDSs and control siphons and (2) to avoid the time to find independent vectors for elementary siphons. We propose a sufficient and necessary test for adjusting control depth variables in S3PR (systems of simple sequential processes with resources) to avoid the sufficient-only time-consuming linear integer programming test (LIP) (Nondeterministic Polynomial (NP) time complete problem) required previously for some cases.

A generalized modal shock spectra method for spacecraft loads analysis. [internal loads in a spacecraft structure subjected to a dynamic launch environment

NASA Technical Reports Server (NTRS)

Trubert, M.; Salama, M.

1979-01-01

Unlike an earlier shock spectra approach, generalization permits an accurate elastic interaction between the spacecraft and launch vehicle to obtain accurate bounds on the spacecraft response and structural loads. In addition, the modal response from a previous launch vehicle transient analysis with or without a dummy spacecraft - is exploited to define a modal impulse as a simple idealization of the actual forcing function. The idealized modal forcing function is then used to derive explicit expressions for an estimate of the bound on the spacecraft structural response and forces. Greater accuracy is achieved with the present method over the earlier shock spectra, while saving much computational effort over the transient analysis.

Digital elevations and extents of regional hydrogeologic units in the Northern Atlantic Coastal Plain aquifer system from Long Island, New York, to North Carolina

USGS Publications Warehouse

Pope, Jason P.; Andreasen, David C.; Mcfarland, E. Randolph; Watt, Martha K.

2016-08-31

Digital geospatial datasets of the extents and top elevations of the regional hydrogeologic units of the Northern Atlantic Coastal Plain aquifer system from Long Island, New York, to northeastern North Carolina were developed to provide an updated hydrogeologic framework to support analysis of groundwater resources. The 19 regional hydrogeologic units were delineated by elevation grids and extent polygons for 20 layers: the land and bathymetric surface at the top of the unconfined surficial aquifer, the upper surfaces of 9 confined aquifers and 9 confining units, and the bedrock surface that defines the base of all Northern Atlantic Coastal Plain sediments. The delineation of the regional hydrogeologic units relied on the interpretive work from source reports for New York, New Jersey, Delaware and Maryland, Virginia, and North Carolina rather than from re-analysis of fundamental hydrogeologic data. This model of regional hydrogeologic unit geometries represents interpolation, extrapolation, and generalization of the earlier interpretive work. Regional units were constructed from available digital data layers from the source studies in order to extend units consistently across political boundaries and approximate units in offshore areas.Though many of the Northern Atlantic Coastal Plain hydrogeologic units may extend eastward as far as the edge of the Atlantic Continental Shelf, the modeled boundaries of all regional hydrogeologic units in this study were clipped to an area approximately defined by the furthest offshore extent of fresh to brackish water in any part of the aquifer system, as indicated by chloride concentrations of 10,000 milligrams per liter. Elevations and extents of units that do not exist onshore in Long Island, New York, were not included north of New Jersey. Hydrogeologic units in North Carolina were included primarily to provide continuity across the Virginia-North Carolina State boundary, which was important for defining the southern edge of the Northern Atlantic Coastal Plain study area.

Revised and extended analysis of the fourth spectrum of indium: In IV

NASA Astrophysics Data System (ADS)

Swapnil; Tauheed, A.

2013-11-01

The spectrum of triply ionized indium (In IV) has been investigated in the wavelength region 245-4443 Å. The In3+ is a Pd-like ion with the ground configuration 4p64d10. All levels of the low lying excited configurations 4d95p, 4d9ns (n=5-7), 4d95d and 4d85s2 have been reported earlier, while for the higher configurations 4d9np (n=6,7) and 4d9nf (n=4-11), only the J=1 levels radiatively decaying to the ground level have been reported. The present work extends the analysis to include the 4d96p, 4d96d, 4d94f and 4d95f configurations. A total 116 levels have been established, 56 of them being new. All the previously reported levels have been confirmed except 4d97s 3D1, 4d97p 3P1, 4d96f 3P1 and 4d85s23P1. The experimental data for the present work was recorded on a 3-m normal incidence spectrograph of St. Francis Xavier University, Antigonish (Canada), as well as on the 10.7 m normal and grazing incidence spectrographs of the National institute of Standards and Technology, Gaithersburg (USA). In both laboratories, a triggered spark source was used. The wavelengths above 2000 Å were supplemented from Bhatia's thesis where an electrodeless discharge source was used. Theoretical predictions were made using Cowan's Hartree-Fock-relativstic atomic codes with superposition of configurations. Least squares fitted (LSF) parametric calculations were used to interpret the energy levels. For vacuum ultraviolet wavelength region our wavelength accuracy is ±0.005 Å. We estimate the ionization potential of In IV to be 450,921.7±86.0 cm-1 (55.9072±0.0106 eV).

Meta-analysis of two randomized controlled trials comparing combined zidovudine and didanosine therapy with combined zidovudine, didanosine, and nevirapine therapy in patients with HIV. INCAS study team.

PubMed

Raboud, J M; Rae, S; Vella, S; Harrigan, P R; Bucciardini, R; Fragola, V; Ricciardulli, D; Montaner, J S

1999-11-01

To extend the range of CD4 counts in which a plasma viral load nadir (pVL) <20 copies/ml was known to be predictive of the duration of virologic response. To determine whether baseline pVL is predictive of virologic response during the study periods. A meta-analysis was conducted of the original individual patient data from two randomized controlled trials comparing zidovudine (ZDV)/didanosine (ddI) with ZDV/ddI/nevirapine (NVP). In total, 87 patients received ZDV/ddI and 83 received ZDV/ddI/NVP. Study subjects on triple therapy with baseline pVL <100,000 copies/ml were more likely to achieve a pVL <400 copies/ml (odds ratio [OR] = 2.49; p = .02) and <20 copies/ml (OR = 4.76; p = .001) during the trial than those with baseline pVL > 100,000 copies/ml. Among triple therapy patients, the relative risk of virologic failure was higher for patients with higher baseline pVL (rate ratio [RR] = 2.51/log10 copies/ ml; p = .01), after controlling for compliance and pVL nadir. The relative risks of virologic failure associated with pVL nadir <20 copies/ml and between 21 and 400 copies/ml were .04 (p = .0001) and .56 (p = .26), respectively, compared with patients with a pVL nadir >400 copies/ml. We have extended our earlier results that achieving a pVL nadir <20 copies/ml is important for maintaining virologic suppression. In particular, we have demonstrated that a pVL nadir <20 copies/ml is at least fivefold more protective against virologic failure than achieving a pVL nadir between 20 and 400 copies/ml. Baseline pVL is significantly associated with the probability of achieving and sustaining virologic suppression.

A submerged singularity method for calculating potential flow velocities at arbitrary near-field points

NASA Technical Reports Server (NTRS)

Maskew, B.

1976-01-01

A discrete singularity method has been developed for calculating the potential flow around two-dimensional airfoils. The objective was to calculate velocities at any arbitrary point in the flow field, including points that approach the airfoil surface. That objective was achieved and is demonstrated here on a Joukowski airfoil. The method used combined vortices and sources ''submerged'' a small distance below the airfoil surface and incorporated a near-field subvortex technique developed earlier. When a velocity calculation point approached the airfoil surface, the number of discrete singularities effectively increased (but only locally) to keep the point just outside the error region of the submerged singularity discretization. The method could be extended to three dimensions, and should improve nonlinear methods, which calculate interference effects between multiple wings, and which include the effects of force-free trailing vortex sheets. The capability demonstrated here would extend the scope of such calculations to allow the close approach of wings and vortex sheets (or vortices).

Evaluative studies in nuclear medicine research: positron computed tomography assessment. Final report, January 1, 1982-December 31, 1982

DOE Office of Scientific and Technical Information (OSTI.GOV)

Potchen, E.J.; Harris, G.I.; Gift, D.A. Reinhard, D.K.

Results are reported of the final phase of the study effort generally titled Evaluative Studies in Nuclear Medicine Research. The previous work is reviewed and extended to an assessment providing perspectives on medical applications of positron emission tomographic (PET) systems, their technological context, and the related economic and marketing environment. Methodologies developed and used in earlier phases of the study were continued, but specifically extended to include solicitation of opinion from commercial organizations deemed to be potential developers, manufacturers and marketers of PET systems. Several factors which influence the demand for clinical uses of PET are evaluated and discussed. Themore » recent Federal funding of applied research with PET systems is found to be a necessary and encouraging event toward a determination that PET either is a powerful research tool limited to research, or whether it also presents major clinical utility. A comprehensive, updated bibliography of current literature related to the development, applications and economic considerations of PET technology is appended.« less

Healthy hearts--and the universal benefits of being physically active: physical activity and health.

PubMed

Blair, Steven N; Morris, Jeremy N

2009-04-01

Although ancient thinkers suggested that physical activity is good for health, systematic research on the topic did not begin until the middle of the 20th century. Early reports showed that individuals in active occupations had lower rates of heart disease than individuals in sedentary occupations. Investigators then began to evaluate leisure-time physical activity and health and found similar results. Later research used objective measures of cardiorespiratory fitness as the exposure, and found even stronger associations with health outcomes. Recent research has extended the earlier findings on activity or fitness and heart disease to a wide variety of health outcomes. We now know that regular physical activity of 150 minutes/week of moderate intensity physical activity reduces the risk of numerous chronic diseases, preserves health and function (both physical and mental) into old age, and extends longevity. The current challenge is to develop programs and interventions to promote physical activity for all in our increasingly sedentary societies.

Framework for Defining and Assessing Benefits of a Modular Assembly Design Approach for Exploration Systems

NASA Technical Reports Server (NTRS)

Dorsey, John T.; Collins, Timothy J.; Moe, Rud V.; Doggett,. William R.

2006-01-01

A comprehensive modular assembly system model has been proposed that extends the art from modular hardware, to include in-space assembly, servicing and repair and it s critical components of infrastructure, agents and assembly operations. Benefits of modular assembly have been identified and a set of metrics defined that extends the art beyond the traditional measures of performance, with emphasis on criteria that allow life-cycle mission costs to be used as a figure of merit (and include all substantive terms that have an impact on the evaluation). The modular assembly approach was used as a basis for developing a Solar Electric Transfer Vehicle (SETV) concept and three modular assembly scenarios were developed. The modular assembly approach also allows the SETV to be entered into service much earlier than competing conventional configurations and results in a great deal of versatility in accommodating different launch vehicle payload capabilities, allowing for modules to be pre-assembled before launch or assembled on orbit, without changing the space vehicle design.

Density functional theory calculations of the turbostratically disordered compound [ ( SnSe ) 1 + y ] m ( VSe 2 ) n

DOE PAGES

Rudin, Sven P.; Johnson, David C.

2015-04-30

Among composite materials that layer constituent substances of nanoscale thicknesses, [(SnSe)1+y ]m(VSe2)n emerges as an example where the constituents retain incommensurate lattice structures. Perpendicular to the stacking direction, the system exhibits random translations and random rotations on average, i.e., turbostratic disorder, with local regions showing twelvefold diffraction patterns. Earlier theoretical work on these structures showed that combining density functional theory with an empirical treatment of the van der Waals interaction gave structural parameters in good agreement with experiment, but no attempt was made to examine the relative orientations. Here we approximate the extended system with one extended constituent and onemore » finite constituent, which allows the treatment of all relative orientations on equal footing. Furthermore, the calculations show how the twelvefold periodicity follows from how the ions of the SnSe layer lock in with favored positions relative to the VSe2 layer, and the associated energy scale supports arguments for the overall turbostratic disorder.« less

Search for the magnetic neutral line in the near-earth plasma sheet 3. An extensive study of magnetic field observations at the lunar distance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lui, A.T.Y.; Meng, C.; Akasofu, S.

1977-09-01

In this paper we have extended our search for the magnetic neutral line in the magnetotail to the lunar distance on the basis of the Explorer 35 magnetic field observations from July 1967 to December 1970. The sign of the B/sub z/ component is found to be predominantly positive during satellite crossings of the midplane (or the so-called neutral sheet) during the substorm expansive phase. Thus combining the present and the earlier results, we conclude that there is no supporting evidence for the formation of a neutral line within the lunar distance during the expansive phase of most substorms. Wemore » also discuss in detail a rare event during the geomagnetic storm of February 2-4, 1969 (Dstapprox.-180 ..gamma..). The magnetic field was observed to be pointing nearly 90/sup 0/ southward with a magnitude of 20-32 ..gamma.. for an extended period.« less

Investigation of low energy space plasma

NASA Technical Reports Server (NTRS)

Comfort, R. H.; Horwitz, J. L.

1986-01-01

A statistical study of 1982 data for occurrences of equatorially trapped plasma has been extended. The previous survey, which utilized only the MSFC summary fiche, has been supplemented with the GSFC summary fiche, which has had the effect of substantially improving the late 1982 coverage. It was found that in the post midnight region (1 - 3 LT), the trapped plasma is limited to + or - 5 degrees magnetic latitude, while in the early afternoon (13-15 LT), latitude ranges as high as + or 30 degrees are found. This survey has provided a link to earlier ATS-6 and ISEE studies of pancake distributions. Although the most energetic, and most anisotopic plasmas are trapped within a few degrees of the equator, the results of these equatorial interactions extend substantially along the magnetic field line in the afternoon and dusk region and these high latitude extensions were previously studied by the Huntsville group. Results of this study were incorporated into a revision of the equatorial ion paper, which has been resubmitted and accepted for publication.

The structure and nature of NGC 2017 IRS. 1: High-resolution radio continuum maps

NASA Technical Reports Server (NTRS)

Smith, Howard A.; Beck, Sara C.

1994-01-01

We have observed the star formation cluster NGC 2071 IRS 1, 2, and 3, with 0.14 sec spatial resolution at 2 cm. The strong source IRS 1 breaks up into a bright peak sitting on a narrow line emission extending over about 400 AU, with three much weaker peaks. This ridge, which has a p.a. = 100 deg, is not aligned with any of the other structures that have previously been seen around IRS 1: its orientation is about 55 deg from the CO outflow direction, and 35 deg from a hypothetical disk direction. The spectral and spatial results, combined with earlier radio and infrared observations, indicate that most likely the radio and infrared emission from the exciting source, IRS 1, is produced by a dense wind hidden by at least 100 visual magnitudes of extinction; the extended ridge of emission comes from an optically thin H II region with characteristic dimensions of approximately AU and which may result from a clumpy distribution of local gas and dust.

Reflected shock tube studies of high-temperature rate constants for OH + CH4 --> CH3 + H2O and CH3 + NO2 --> CH3O + NO.

PubMed

Srinivasan, N K; Su, M-C; Sutherland, J W; Michael, J V

2005-03-10

The reflected shock tube technique with multipass absorption spectrometric detection of OH radicals at 308 nm has been used to study the reactions OH + CH(4) --> CH(3) + H(2)O and CH(3) + NO(2) --> CH(3)O + NO. Over the temperature range 840-2025 K, the rate constants for the first reaction can be represented by the Arrhenius expression k = (9.52 +/- 1.62) x 10(-11) exp[(-4134 +/- 222 K)/T] cm(3) molecule(-1) s(-1). Since this reaction is important in both combustion and atmospheric chemistry, there have been many prior investigations with a variety of techniques. The present results extend the temperature range by 500 K and have been combined with the most accurate earlier studies to derive an evaluation over the extended temperature range 195-2025 K. A three-parameter expression describes the rate behavior over this temperature range, k = (1.66 x 10(-18))T(2.182) exp[(-1231 K)/T] cm(3) molecule(-1) s(-1). Previous theoretical studies are discussed, and the present evaluation is compared to earlier theoretical estimates. Since CH(3) radicals are a product of the reaction and could cause secondary perturbations in rate constant determinations, the second reaction was studied by OH radical production from the fast reactions CH(3)O --> CH(2)O + H and H + NO(2) --> OH + NO. The measured rate constant is 2.26 x 10(-11) cm(3) molecule(-1) s(-1) and is not dependent on temperature from 233 to 1700 K within experimental error.

Shortening the incubation time for the combination disk diffusion extended-spectrum β-lactamase (ESBL) confirmation test: how far can we go?

PubMed

van den Bijllaardt, Wouter; Voermans, Patricia C M; Buiting, Anton G; Mouton, Johan W; Muller, Anouk E

2017-09-01

The combination disk diffusion extended-spectrum β-lactamase (ESBL) confirmation test (CDT) is used for the confirmation of ESBL production in Enterobacteriaceae and usually takes 16-20 h to results. In this study, we searched for the shortest possible incubation time without a reduction in reliability. A total of 125 ESBL screening-positive isolates were subjected to CDT and were molecularly characterised by microarray. Inhibition zones were read every hour over 6-18 h of incubation. Concordance between earlier and 18-h readings was calculated for each hour. Results were validated on 224 isolates during routine clinical practice. For the initial 125 isolates, concordance (Cohen's κ) between the 6-h and 18-h readings was 0.88 [95% confidence interval (CI) 0.78-0.96; P <0.001]. The earliest time point for full concordance with the 18-h reading was 10 h. Validation of the 10-h reading for 224 clinical isolates resulted in a concordance of 0.99 (95% CI 0.98-1.0) between the 10-h and 18-h readings. Overall concordance on all 349 isolates was 0.99 (95% CI 0.97-1.0). Reading after 10 h of incubation has an excellent correlation with results after 18 h of incubation. This can significantly reduce the turnaround time for ESBL detection in laboratories with long opening hours or providing a 24/7 service. Consequently, there is a potential for implementing infection control measures up to 8 h earlier. Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Xuecao; Zhou, Yuyu; Asrar, Ghassem R.

The influence of urbanization on vegetation phenology is gaining considerable attention due to its implications for human health, cycling of carbon and other nutrients in Earth system. In this study, we examined the relationship between change in vegetation phenology and urban size, an indicator of urbanization, for the conterminous United States. We studied more than 4500 urban clusters of varying size to determine the impact of urbanization on plant phenology, with the aids of remotely sensed observations since 2003–2012. We found that phenology cycle (changes in vegetation greenness) in urban areas starts earlier (start of season, SOS) and ends latermore » (end of season, EOS), resulting in a longer growing season length (GSL), when compared to the respective surrounding urban areas. The average difference of GSL between urban and rural areas over all vegetation types, considered in this study, is about 9 days.Also, the extended GSL in urban area is consistent among different climate zones in the United States, whereas their magnitudes are varying across regions. We found that a tenfold increase in urban size could result in an earlier SOS of about 1.3 days and a later EOS of around 2.4 days. As a result, the GSL could be extended by approximately 3.6 days with a range of 1.6–6.5 days for 25th ~ 75th quantiles, with a median value of about 2.1 days. For different vegetation types, the phenology response to urbanization, as defined by GSL, ranges from 1 to 4 days. In conclusion, the quantitative relationship between phenology and urbanization is of great use for developing improved models of vegetation phenology dynamics under future urbanization, and for developing change indicators to assess the impacts of urbanization on vegetation phenology.« less

Response of vegetation phenology to urbanization in the conterminous United States

DOE PAGES

Li, Xuecao; Zhou, Yuyu; Asrar, Ghassem R.; ...

2016-12-18

The influence of urbanization on vegetation phenology is gaining considerable attention due to its implications for human health, cycling of carbon and other nutrients in Earth system. In this study, we examined the relationship between change in vegetation phenology and urban size, an indicator of urbanization, for the conterminous United States. We studied more than 4500 urban clusters of varying size to determine the impact of urbanization on plant phenology, with the aids of remotely sensed observations since 2003–2012. We found that phenology cycle (changes in vegetation greenness) in urban areas starts earlier (start of season, SOS) and ends latermore » (end of season, EOS), resulting in a longer growing season length (GSL), when compared to the respective surrounding urban areas. The average difference of GSL between urban and rural areas over all vegetation types, considered in this study, is about 9 days.Also, the extended GSL in urban area is consistent among different climate zones in the United States, whereas their magnitudes are varying across regions. We found that a tenfold increase in urban size could result in an earlier SOS of about 1.3 days and a later EOS of around 2.4 days. As a result, the GSL could be extended by approximately 3.6 days with a range of 1.6–6.5 days for 25th ~ 75th quantiles, with a median value of about 2.1 days. For different vegetation types, the phenology response to urbanization, as defined by GSL, ranges from 1 to 4 days. In conclusion, the quantitative relationship between phenology and urbanization is of great use for developing improved models of vegetation phenology dynamics under future urbanization, and for developing change indicators to assess the impacts of urbanization on vegetation phenology.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Xuecao; Zhou, Yuyu; Asrar, Ghassem R.

The influence of urbanization on vegetation phenology is gaining considerable attention due to its implications for human health, cycling of carbon and other nutrients in Earth system. In this study, we examined the relationship between change in vegetation phenology and urban size, an indicator of urbanization, for the conterminous United States. We studied more than 4500 urban clusters of varying size to determine the impact of urbanization on plant phenology, with the aids of remotely sensed observations since 2003–2012. We found that phenology cycle (changes in vegetation greenness) in rural areas starts earlier (start of season, SOS) and ends latermore » (end of season, EOS), resulting in a longer growing season length (GSL), when compared to the respective surrounding urban areas. The average difference of GSL between urban and rural areas over all vegetation types, considered in this study, is about 9 days. Also, the extended GSL in urban area is consistent among different climate zones in the United States, whereas their magnitudes are varying across regions. We found that a tenfold increase in urban size could result in an earlier SOS of about 1.3 days and a later EOS of around 2.4 days. As a result, the GSL could be extended by approximately 3.6 days with a range of 1.6–6.5 days for 25th ~ 75th quantiles, with a median value of about 2.1 days. For different vegetation types, the phenology response to urbanization, as defined by GSL, ranges from 1 to 4 days. The quantitative relationship between phenology and urbanization is of great use for developing improved models of vegetation phenology dynamics under future urbanization, and for developing change indicators to assess the impacts of urbanization on vegetation phenology.« less

High School Teaching and College Performance: Looking for Connections

NASA Astrophysics Data System (ADS)

Tai, Robert H.

2006-12-01

How much impact does high school have on college? Are decisions about classroom activities and student work in high school physics associated with student performance in college physics? In our paper, we look at several aspects of high school physics including laboratory experiences, homework activities, and classroom activities and their association with college physics grades. Our results revisit in greater depth and earlier analysis carried out a decade earlier.

Text mining to decipher free-response consumer complaints: insights from the NHTSA vehicle owner's complaint database.

PubMed

Ghazizadeh, Mahtab; McDonald, Anthony D; Lee, John D

2014-09-01

This study applies text mining to extract clusters of vehicle problems and associated trends from free-response data in the National Highway Traffic Safety Administration's vehicle owner's complaint database. As the automotive industry adopts new technologies, it is important to systematically assess the effect of these changes on traffic safety. Driving simulators, naturalistic driving data, and crash databases all contribute to a better understanding of how drivers respond to changing vehicle technology, but other approaches, such as automated analysis of incident reports, are needed. Free-response data from incidents representing two severity levels (fatal incidents and incidents involving injury) were analyzed using a text mining approach: latent semantic analysis (LSA). LSA and hierarchical clustering identified clusters of complaints for each severity level, which were compared and analyzed across time. Cluster analysis identified eight clusters of fatal incidents and six clusters of incidents involving injury. Comparisons showed that although the airbag clusters across the two severity levels have the same most frequent terms, the circumstances around the incidents differ. The time trends show clear increases in complaints surrounding the Ford/Firestone tire recall and the Toyota unintended acceleration recall. Increases in complaints may be partially driven by these recall announcements and the associated media attention. Text mining can reveal useful information from free-response databases that would otherwise be prohibitively time-consuming and difficult to summarize manually. Text mining can extend human analysis capabilities for large free-response databases to support earlier detection of problems and more timely safety interventions.

Within-Subject Correlation Analysis to Detect Functional Areas Associated With Response Inhibition.

PubMed

Yamasaki, Tomoko; Ogawa, Akitoshi; Osada, Takahiro; Jimura, Koji; Konishi, Seiki

2018-01-01

Functional areas in fMRI studies are often detected by brain-behavior correlation, calculating across-subject correlation between the behavioral index and the brain activity related to a function of interest. Within-subject correlation analysis is also employed in a single subject level, which utilizes cognitive fluctuations in a shorter time period by correlating the behavioral index with the brain activity across trials. In the present study, the within-subject analysis was applied to the stop-signal task, a standard task to probe response inhibition, where efficiency of response inhibition can be evaluated by the stop-signal reaction time (SSRT). Since the SSRT is estimated, by definition, not in a trial basis but from pooled trials, the correlation across runs was calculated between the SSRT and the brain activity related to response inhibition. The within-subject correlation revealed negative correlations in the anterior cingulate cortex and the cerebellum. Moreover, the dissociation pattern was observed in the within-subject analysis when earlier vs. later parts of the runs were analyzed: negative correlation was dominant in earlier runs, whereas positive correlation was dominant in later runs. Regions of interest analyses revealed that the negative correlation in the anterior cingulate cortex, but not in the cerebellum, was dominant in earlier runs, suggesting multiple mechanisms associated with inhibitory processes that fluctuate on a run-by-run basis. These results indicate that the within-subject analysis compliments the across-subject analysis by highlighting different aspects of cognitive/affective processes related to response inhibition.

Social Exclusion Index-for Health Surveys (SEI-HS): a prospective nationwide study to extend and validate a multidimensional social exclusion questionnaire.

PubMed

van Bergen, Addi P L; Hoff, Stella J M; Schreurs, Hanneke; van Loon, Annelies; van Hemert, Albert M

2017-03-14

Social exclusion (SE) refers to the inability of certain groups or individuals to fully participate in society. SE is associated with socioeconomic inequalities in health, and its measurement in routine public health monitoring is considered key to designing effective health policies. In an earlier retrospective analysis we demonstrated that in all four major Dutch cities, SE could largely be measured with existing local public health monitoring data. The current prospective study is aimed at constructing and validating an extended national measure for SE that optimally employs available items. In 2012, a stratified general population sample of 258,928 Dutch adults completed a version of the Netherlands Public Health Monitor (PHM) questionnaire in which 9 items were added covering aspects of SE that were found to be missing in our previous research. Items were derived from the SCP social exclusion index, a well-constructed 15-item instrument developed by the Netherlands Institute for Social Research (SCP). The dataset was randomly divided into a development sample (N =129,464) and a validation sample (N = 129,464). Canonical correlation analysis was conducted in the development sample. The psychometric properties were studied and compared with those of the original SCP index. All analyses were then replicated in the validation sample. The analysis yielded a four dimensional index, the Social Exclusion Index for Health Surveys (SEI-HS), containing 8 SCP items and 9 PHM items. The four dimensions: "lack of social participation", "material deprivation", "lack of normative integration" and "inadequate access to basic social rights", were each measured with 3 to 6 items. The SEI-HS showed adequate internal consistency for both the general index and for two of four dimension scales. The internal structure and construct validity of the SEI-HS were satisfactory and similar to the original SCP index. Replication of the SEI-HS in the validation sample confirmed its generalisability. This study demonstrates that the SEI-HS offers epidemiologists and public health researchers a uniform, reliable, valid and efficient means of assessing social exclusion and its underlying dimensions. The study also provides valuable insights in how to develop embedded measures for public health surveillance.

The Crust and Upper Mantle Structure of the Iranian Plateau from Joint Waveform Tomography Imaging of Body and Surface Waves

NASA Astrophysics Data System (ADS)

Roecker, S. W.; Priestley, K. F.; Tatar, M.

2014-12-01

The Iranian Plateau forms a broad zone of deformation between the colliding Arabian and Eurasian plates. The convergence is accommodated in the Zagros Mountains of SW Iran, the Alborz Mountains of northern Iran, and the Kopeh Dagh Mountains of NE Iran. These deforming belts are separated by relatively aseismic depressions such as the Lut Block. It has been suggested that the Arabia-Eurasia collision is similar to the Indo-Eurasia collision but at a early point of development and therefore, it may provide clues to our understanding of the earlier stages of the continent-continent collision process. We present results of the analysis of seismic data collected along two NE-SW trending transects across the Iranian Plateau. The first profile extends from near Bushere on the Persian Gulf coast to near to the Iran-Turkmenistan border north of Mashad, and consists of seismic recordings along the SW portion of the line in 2000-2001 and recording along the NE portion of the line in 2003 and 2006-2008. The second profile extends from near the Iran-Iraq border near the Dezfel embayment to the south Caspian Sea coast north of Tehran. We apply the combined 2.5D finite element waveform tomography algorithm of Baker and Roecker [2014] to jointly invert teleseismic body and surface waves to determine the elastic wavespeed structures of these areas. The joint inversion of these different types of waves affords similar types of advantages that are common to combined surface wave dispersion/receiver function inversions in compensating for intrinsic weaknesses in horizontal and vertical resolution capabilities. We compare results recovered from a finite difference approach to document the effects of various assumptions related to their application, such as the inclusion of topography, on the models recovered. We also apply several different inverse methods, starting with simple gradient techniques to the more sophisticated pseudo-Hessian or L-BFGS approach, and find that the latter are generally more robust. Modeling of receiver functions and surface wave dispersion prior to the analysis is shown to be an efficacious way to generate starting models for this analysis.

Double-strangeness production in {bar p}Xe annihilation at low energy in the DIANA chamber

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barmin, V.V.; Barylov, V.G.; Chernukha, S.F.

1994-09-01

From the analysis of about 10{sup 5} annihilations of antiprotons at rest and in flight (0.4 - 0.9 GeV/c) on Xe nuclei, new results are presented for the final state K{sup 0}{sub s}SX (S = K{sup 0}{sub s}, K{sup {minus}}, {Lambda}, {Sigma}{sup 0}, {Sigma}{sup +-}). From these results and from earlier results for the final state K{sup +}SX, inclusive and semiinclusive yields are determined, giving virtually all strange channels. The effective strangeness contents were deduced to be 5.5% at rest and 5.3% in flight. In addition to 14 events reported earlier in the final states K{sup +}K{sup +}X and K{supmore » +}K{sup 0}{sub s}{Lambda}X and based on an analysis of 5.4 x 10{sup 5} annihilations, three new events were found in a further analysis of 10{sup 5} annihilations. The new events, together with the revised yields and momentum and mass distributions, are presented. The results confirm earlier results on the effective mass of {Lambda}{Lambda} and a determination of the preferable cascade process.« less

Lawson's Shoehorn, Reprise

ERIC Educational Resources Information Center

Allchin, Douglas

2006-01-01

Lawson's (Lawson, A.: 2004, Science & Education, 13, 155-177) analysis of the meteorite hypothesis of dinosaur extinction exhibits flaws similar to his earlier (2002) analysis of Galileo's discovery of Jupiter's moons (Allchin, D.: 2003, Science & Education, 12, 315-329).

LIPID ABNORMALITIES IN SUCCINATE SEMIALDEHYDE DEHYDROGENASE (Aldh5a1−/−) DEFICIENT MOUSE BRAIN PROVIDE ADDITIONAL EVIDENCE FOR MYELIN ALTERATIONS

PubMed Central

Barcelo-Coblijn, G.; Murphy, E. J.; Mills, K.; Winchester, B.; Jakobs, C.; Snead, O.C.; Gibson, KM

2007-01-01

Earlier work from our laboratory provided evidence for myelin abnormalities (decreased quantities of proteins associated with myelin compaction, decreased sheath thickness) in cortex and hippocampus of Aldh5a1−/− mice, which have a complete ablation of the succinate semialdehyde dehydrogenase protein [1]. In the current report, we have extended these findings via comprehensive analysis of brain phospholipid fractions, including quantitation of fatty acids in individual phospholipid subclasses and estimation of hexose-ceramide in Aldh5a1−/− brain. In comparison to wild-type littermates (Aldh5a1+/+), we detected a 20% reduction in the ethanolamine glycerophospholipid content of Aldh5a1−/− mice, while other brain phospholipids (choline glycerophospholipid, phosphatidylserine and phosphatidylinositol) were within normal limits. Analysis of individual fatty acids in each of these fractions revealed consistent alterations in n-3 fatty acids, primarily increased 22:6n-3 levels (docosahexaenoic acid; DHA). In the phosphatidyl serine fraction there were marked increases in the proportions of polyunsaturated fatty acids with corresponding decreases of monounsaturated fatty acids. Interestingly, the levels of hexose-ceramide (glucosyl- and galactosylceramide, principal myelin cerebrosides) were decreased in Aldh5a1−/− brain tissue (one-tailed t test, p=0.0449). The current results suggest that lipid and myelin abnormalities in this animal may contribute to the pathophysiology. PMID:17300923

Epidemiological characterization of a nosocomial outbreak of extended spectrum β-lactamase Escherichia coli ST-131 confirms the clinical value of core genome multilocus sequence typing.

PubMed

Woksepp, Hanna; Ryberg, Anna; Berglind, Linda; Schön, Thomas; Söderman, Jan

2017-12-01

Enhanced precision of epidemiological typing in clinically suspected nosocomial outbreaks is crucial. Our aim was to investigate whether single nucleotide polymorphism (SNP) analysis and core genome (cg) multilocus sequence typing (MLST) of whole genome sequencing (WGS) data would more reliably identify a nosocomial outbreak, compared to earlier molecular typing methods. Sixteen isolates from a nosocomial outbreak of ESBL E. coli ST-131 in southeastern Sweden and three control strains were subjected to WGS. Sequences were explored by SNP analysis and cgMLST. cgMLST clearly differentiated between the outbreak isolates and the control isolates (>1400 differences). All clinically identified outbreak isolates showed close clustering (≥2 allele differences), except for two isolates (>50 allele differences). These data confirmed that the isolates with >50 differing genes did not belong to the nosocomial outbreak. The number of SNPs within the outbreak was ≤7, whereas the two discrepant isolates had >700 SNPs. Two of the ESBL E. coli ST-131 isolates did not belong to the clinically identified outbreak. Our results illustrate the power of WGS in terms of resolution, which may avoid overestimation of patients belonging to outbreaks as judged from epidemiological data and previously employed molecular methods with lower discriminatory ability. © 2017 APMIS. Published by John Wiley & Sons Ltd.

Thermal neutral format based on the step technology

NASA Technical Reports Server (NTRS)

Almazan, P. Planas; Legal, J. L.

1995-01-01

The exchange of models is one of the most serious problems currently encountered in the practice of spacecraft thermal analysis. Essentially, the problem originates in the diversity of computing environments that are used across different sites, and the consequent proliferation of native tool formats. Furthermore, increasing pressure to reduce the development's life cycle time has originated a growing interest in the so-called spacecraft concurrent engineering. In this context, the realization of the interdependencies between different disciplines and the proper communication between them become critical issues. The use of a neutral format represents a step forward in addressing these problems. Such a means of communication is adopted by consensus. A neutral format is not directly tied to any specific tool and it is kept under stringent change control. Currently, most of the groups promoting exchange formats are contributing with their experience to STEP, the Standard for Exchange of Product Model Data, which is being developed under the auspices of the International Standards Organization (ISO 10303). This paper presents the different efforts made in Europe to provide the spacecraft thermal analysis community with a Thermal Neutral Format (TNF) based on STEP. Following an introduction with some background information, the paper presents the characteristics of the STEP standard. Later, the first efforts to produce a STEP Spacecraft Thermal Application Protocol are described. Finally, the paper presents the currently harmonized European activities that follow up and extend earlier work on the area.

The forced vibration of one-dimensional multi-coupled periodic structures: An application to finite element analysis

NASA Astrophysics Data System (ADS)

Mead, Denys J.

2009-01-01

A general theory for the forced vibration of multi-coupled one-dimensional periodic structures is presented as a sequel to a much earlier general theory for free vibration. Starting from the dynamic stiffness matrix of a single multi-coupled periodic element, it derives matrix equations for the magnitudes of the characteristic free waves excited in the whole structure by prescribed harmonic forces and/or displacements acting at a single periodic junction. The semi-infinite periodic system excited at its end is first analysed to provide the basis for analysing doubly infinite and finite periodic systems. In each case, total responses are found by considering just one periodic element. An already-known method of reducing the size of the computational problem is reexamined, expanded and extended in detail, involving reduction of the dynamic stiffness matrix of the periodic element through a wave-coordinate transformation. Use of the theory is illustrated in a combined periodic structure+finite element analysis of the forced harmonic in-plane motion of a uniform flat plate. Excellent agreement between the computed low-frequency responses and those predicted by simple engineering theories validates the detailed formulations of the paper. The primary purpose of the paper is not towards a specific application but to present a systematic and coherent forced vibration theory, carefully linked with the existing free-wave theory.

The effects of road traffic and aircraft noise exposure on children's episodic memory: the RANCH project.

PubMed

Matheson, Mark; Clark, Charlotte; Martin, Rocio; van Kempen, Elise; Haines, Mary; Barrio, Isabel Lopez; Hygge, Staffan; Stansfeld, Stephen

2010-01-01

Previous studies have found that chronic exposure to aircraft noise has a negative effect on children's performance on tests of episodic memory. The present study extended the design of earlier studies in three ways: firstly, by examining the effects of two noise sources, aircraft and road traffic, secondly, by examining exposure-effect relationships, and thirdly, by carrying out parallel field studies in three European countries, allowing cross-country comparisons to be made. A total of 2844 children aged between 8 years 10 months and 12 years 10 months (mean age 10 years 6 months) completed classroom-based tests of cued recall, recognition memory and prospective memory. Questionnaires were also completed by the children and their parents in order to provide information about socioeconomic context. Multilevel modeling analysis revealed aircraft noise to be associated with an impairment of recognition memory in a linear exposure-effect relationship. The analysis also found road traffic noise to be associated with improved performance on cued recall in a linear exposure-effect relationship. No significant association was found between exposure to aircraft noise and cued recall or prospective memory. Likewise, no significant association was found between road traffic noise and recognition or prospective memory. Taken together, these findings indicate that exposure to aircraft noise and road traffic noise can impact on certain aspects of children's episodic memory.

Structure-Based Phylogenetic Analysis of the Lipocalin Superfamily.

PubMed

Lakshmi, Balasubramanian; Mishra, Madhulika; Srinivasan, Narayanaswamy; Archunan, Govindaraju

2015-01-01

Lipocalins constitute a superfamily of extracellular proteins that are found in all three kingdoms of life. Although very divergent in their sequences and functions, they show remarkable similarity in 3-D structures. Lipocalins bind and transport small hydrophobic molecules. Earlier sequence-based phylogenetic studies of lipocalins highlighted that they have a long evolutionary history. However the molecular and structural basis of their functional diversity is not completely understood. The main objective of the present study is to understand functional diversity of the lipocalins using a structure-based phylogenetic approach. The present study with 39 protein domains from the lipocalin superfamily suggests that the clusters of lipocalins obtained by structure-based phylogeny correspond well with the functional diversity. The detailed analysis on each of the clusters and sub-clusters reveals that the 39 lipocalin domains cluster based on their mode of ligand binding though the clustering was performed on the basis of gross domain structure. The outliers in the phylogenetic tree are often from single member families. Also structure-based phylogenetic approach has provided pointers to assign putative function for the domains of unknown function in lipocalin family. The approach employed in the present study can be used in the future for the functional identification of new lipocalin proteins and may be extended to other protein families where members show poor sequence similarity but high structural similarity.

Pseudoautosomal region in schizophrenia: linkage analysis of seven loci by sib-pair and lod-score methods.

PubMed

d'Amato, T; Waksman, G; Martinez, M; Laurent, C; Gorwood, P; Campion, D; Jay, M; Petit, C; Savoye, C; Bastard, C

1994-05-01

In a previous study, we reported a nonrandom segregation between schizophrenia and the pseudoautosomal locus DXYS14 in a sample of 33 sibships. That study has been extended by the addition of 16 new sibships from 16 different families. Data from six other loci of the pseudoautosomal region and of the immediately adjacent part of the X specific region have also been analyzed. Two methods of linkage analysis were used: the affected sibling pair (ASP) method and the lod-score method. Lod-score analyses were performed on the basis of three different models--A, B, and C--all shown to be consistent with the epidemiological data on schizophrenia. No clear evidence for linkage was obtained with any of these models. However, whatever the genetic model and the disease classification, maximum lod scores were positive with most of the markers, with the highest scores generally being obtained for the DXYS14 locus. When the ASP method was used, the earlier finding of nonrandom segregation between schizophrenia and the DXYS14 locus was still supported in this larger data set, at an increased level of statistical significance. Findings of ASP analyses were not significant for the other loci. Thus, findings obtained from analyses using the ASP method, but not the lod-score method, were consistent with the pseudoautosomal hypothesis for schizophrenia.

Evaluating the intensity of fire at the Acheulian site of Gesher Benot Ya'aqov—Spatial and thermoluminescence analyses

PubMed Central

Richter, Daniel; Goren-Inbar, Naama

2017-01-01

This manuscript presents an attempt to evaluate the intensity of fire through spatial patterning and thermoluminescence methodology. Previous studies of Layer II-6 Level 2 at the Acheulian site of Gesher Benot Ya‘aqov suggested that hominins differentiated their activities across space, including multiple activities around a hearth reconstructed on the basis of the distribution of burned flint artifacts. A transect of ~4 m was extended from the center of the reconstructed hearth of Level 2 to its periphery in order to examine the intensity of fire. Burned and unburned flint microartifacts were sampled along this transect. The results of earlier and current thermoluminescence (TL) analysis demonstrate a general agreement with the macroscopic determination of burning, indicating that the possibility of misinterpretation based on macroscopic observations is negligible. The TL signal from flint microartifacts close to the hearth’s center shows unambiguous signs of strong heating, whereas with increasing distance from the hearth the TL signal can be interpreted as a result of decreasing temperatures and/or shorter durations of exposure to fire in addition to a decreasing number of flints showing fire damage. Our study shows that TL analysis can identify some variation in fire intensity, which allows a more precise classification of burned flint microartifacts with respect to their heating history. PMID:29145432

COMMIX-PPC: A three-dimensional transient multicomponent computer program for analyzing performance of power plant condensers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chien, T.H.; Domanus, H.M.; Sha, W.T.

1993-02-01

The COMMIX-PPC computer pregrain is an extended and improved version of earlier COMMIX codes and is specifically designed for evaluating the thermal performance of power plant condensers. The COMMIX codes are general-purpose computer programs for the analysis of fluid flow and heat transfer in complex Industrial systems. In COMMIX-PPC, two major features have been added to previously published COMMIX codes. One feature is the incorporation of one-dimensional equations of conservation of mass, momentum, and energy on the tube stile and the proper accounting for the thermal interaction between shell and tube side through the porous-medium approach. The other added featuremore » is the extension of the three-dimensional conservation equations for shell-side flow to treat the flow of a multicomponent medium. COMMIX-PPC is designed to perform steady-state and transient. Three-dimensional analysis of fluid flow with heat transfer tn a power plant condenser. However, the code is designed in a generalized fashion so that, with some modification, it can be used to analyze processes in any heat exchanger or other single-phase engineering applications. Volume I (Equations and Numerics) of this report describes in detail the basic equations, formulation, solution procedures, and models for a phenomena. Volume II (User's Guide and Manual) contains the input instruction, flow charts, sample problems, and descriptions of available options and boundary conditions.« less

Limit analysis of hollow spheres or spheroids with Hill orthotropic matrix

NASA Astrophysics Data System (ADS)

Pastor, Franck; Pastor, Joseph; Kondo, Djimedo

2012-03-01

Recent theoretical studies of the literature are concerned by the hollow sphere or spheroid (confocal) problems with orthotropic Hill type matrix. They have been developed in the framework of the limit analysis kinematical approach by using very simple trial velocity fields. The present Note provides, through numerical upper and lower bounds, a rigorous assessment of the approximate criteria derived in these theoretical works. To this end, existing static 3D codes for a von Mises matrix have been easily extended to the orthotropic case. Conversely, instead of the non-obvious extension of the existing kinematic codes, a new original mixed approach has been elaborated on the basis of the plane strain structure formulation earlier developed by F. Pastor (2007). Indeed, such a formulation does not need the expressions of the unit dissipated powers. Interestingly, it delivers a numerical code better conditioned and notably more rapid than the previous one, while preserving the rigorous upper bound character of the corresponding numerical results. The efficiency of the whole approach is first demonstrated through comparisons of the results to the analytical upper bounds of Benzerga and Besson (2001) or Monchiet et al. (2008) in the case of spherical voids in the Hill matrix. Moreover, we provide upper and lower bounds results for the hollow spheroid with the Hill matrix which are compared to those of Monchiet et al. (2008).

Extrapolating the Trends of Test Drop Data with Opening Shock Factor Calculations: the Case of the Orion Main and Drogue Parachutes Inflating to 1st Reefed Stage

NASA Technical Reports Server (NTRS)

Potvin, Jean; Ray, Eric

2017-01-01

We describe a new calculation of the opening shock factor C (sub k) characterizing the inflation performance of NASA's Orion spacecraft main and drogue parachutes opening under a reefing constraint (1st stage reefing), as currently tested in the Capsule Parachute Assembly System (CPAS) program. This calculation is based on an application of the Momentum-Impulse Theorem at low mass ratio (R (sub m) is less than 10 (sup -1)) and on an earlier analysis of the opening performance of drogues decelerating point masses and inflating along horizontal trajectories. Herein we extend the reach of the Theorem to include the effects of payload drag and gravitational impulse during near-vertical motion - both important pre-requisites for CPAS parachute analysis. The result is a family of C (sub k) versus R (sub m) curves which can be used for extrapolating beyond the drop-tested envelope. The paper proves this claim in the case of the CPAS Mains and Drogues opening while trailing either a Parachute Compartment Drop Test Vehicle or a Parachute Test Vehicle (an Orion capsule boiler plate). It is seen that in all cases the values of the opening shock factor can be extrapolated over a range in mass ratio that is at least twice that of the test drop data.

Extended studies of Baltomyces styrax in Idaho and expanded distribution of this isopod gut fungus in USA.

PubMed

Oman, Sarah J; White, Merlin M

2012-01-01

Trichomycetes or gut fungi are currently considered to be an ecological group consisting of both fungi and protists that inhabit the guts of arthropods from varied environments. Baltomyces styrax has been included as a member of the Asellariales, a small and understudied order of true gut fungi. Baltomyces styrax has remained monotypic and not been reported formally since it was first described by Cafaro in 1999 from one collection in Louisiana. Herein we report on subsequent collections of this fungus, from both lentic and lotic locations, over the past several years from four other states, most recently Idaho, where we have records over a 4 y span. We repeatedly collected at one lentic site in Idaho for 5 mo, which allowed an extended study of not only the life history of B. styrax but also the discovery of morphological characteristics that were not reported earlier. Therefore we are emending the species description and providing additional information on the ecology and host range of B. styrax as well as providing a context for comparison to Asellaria, the type genus of the Asellariales. We also extend the known host range and suggest that the fungus is much more widespread than current records indicate.

Combining density functional and incremental post-Hartree-Fock approaches for van der Waals dominated adsorbate-surface interactions: Ag{sub 2}/graphene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lara-Castells, María Pilar de, E-mail: Pilar.deLara.Castells@csic.es; Mitrushchenkov, Alexander O.; Stoll, Hermann

2015-09-14

A combined density functional (DFT) and incremental post-Hartree-Fock (post-HF) approach, proven earlier to calculate He-surface potential energy surfaces [de Lara-Castells et al., J. Chem. Phys. 141, 151102 (2014)], is applied to describe the van der Waals dominated Ag{sub 2}/graphene interaction. It extends the dispersionless density functional theory developed by Pernal et al. [Phys. Rev. Lett. 103, 263201 (2009)] by including periodic boundary conditions while the dispersion is parametrized via the method of increments [H. Stoll, J. Chem. Phys. 97, 8449 (1992)]. Starting with the elementary cluster unit of the target surface (benzene), continuing through the realistic cluster model (coronene), andmore » ending with the periodic model of the extended system, modern ab initio methodologies for intermolecular interactions as well as state-of-the-art van der Waals-corrected density functional-based approaches are put together both to assess the accuracy of the composite scheme and to better characterize the Ag{sub 2}/graphene interaction. The present work illustrates how the combination of DFT and post-HF perspectives may be efficient to design simple and reliable ab initio-based schemes in extended systems for surface science applications.« less

Economic Benefits of Improved Information on Worldwide Crop Production: An Optimal Decision Model of Production and Distribution with Application to Wheat, Corn, and Soybeans

NASA Technical Reports Server (NTRS)

Andrews, J.

1977-01-01

An optimal decision model of crop production, trade, and storage was developed for use in estimating the economic consequences of improved forecasts and estimates of worldwide crop production. The model extends earlier distribution benefits models to include production effects as well. Application to improved information systems meeting the goals set in the large area crop inventory experiment (LACIE) indicates annual benefits to the United States of $200 to $250 million for wheat, $50 to $100 million for corn, and $6 to $11 million for soybeans, using conservative assumptions on expected LANDSAT system performance.

Tridimensional personality questionnaire: assessment in patients with social phobia and a control group.

PubMed

Kim, S W; Hoover, K M

1996-02-01

We administered the Tridimensional Personality Questionnaire to 40 control subjects and to 47 social phobia patients who met Structured Clinical Interview for DSM-III-R (SCID) criteria for social phobia and participated in a multicenter treatment study. Multiple comparisons with Bonferroni correction showed a significant increase in total Harm Avoidance scale scores and all four subscale scores for the social phobia group. On a Reward Dependence subscale that measures persistence versus irresoluteness the mean was significantly lower in the social phobia group than the control group. Present findings extend an earlier report of increased Harm Avoidance in major depressive disorder and other clinical diagnostic groups.

Computational studies of photoluminescence from disordered nanocrystalline systems

NASA Astrophysics Data System (ADS)

John, George

2000-03-01

The size (d) dependence of emission energies from semiconductor nanocrystallites have been shown to follow an effective exponent ( d^-β) determined by the disorder in the system(V.Ranjan, V.A.Singh and G.C.John, Phys. Rev B 58), 1158 (1998). Our earlier calculation was based on a simple quantum confinement model assuming a normal distribution of crystallites. This model is now extended to study the effects of realistic systems with a lognormal distribution in particle size, accounting for carrier hopping and nonradiative transitions. Computer simulations of this model performed using the Microcal Origin software can explain several conflicting experimental results reported in literature.

Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015.

PubMed

Hernández, Marta; Iglesias, M Rocío; Rodríguez-Lázaro, David; Gallardo, Alejandro; Quijada, Narciso; Miguela-Villoldo, Pedro; Campos, Maria Jorge; Píriz, Segundo; López-Orozco, Gema; de Frutos, Cristina; Sáez, José Luis; Ugarte-Ruiz, María; Domínguez, Lucas; Quesada, Alberto

2017-08-03

Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States. This article is copyright of The Authors, 2017.

Fixed-time stabilization of impulsive Cohen-Grossberg BAM neural networks.

PubMed

Li, Hongfei; Li, Chuandong; Huang, Tingwen; Zhang, Wanli

2018-02-01

This article is concerned with the fixed-time stabilization for impulsive Cohen-Grossberg BAM neural networks via two different controllers. By using a novel constructive approach based on some comparison techniques for differential inequalities, an improvement theorem of fixed-time stability for impulsive dynamical systems is established. In addition, based on the fixed-time stability theorem of impulsive dynamical systems, two different control protocols are designed to ensure the fixed-time stabilization of impulsive Cohen-Grossberg BAM neural networks, which include and extend the earlier works. Finally, two simulations examples are provided to illustrate the validity of the proposed theoretical results. Copyright © 2017 Elsevier Ltd. All rights reserved.

Tunneling of Massive Flux Lines in a High Tc Superconductor at absolute Zero

NASA Astrophysics Data System (ADS)

Narahari Achar, B. N.; Waleed Gaber, M.

1997-11-01

Our previous study(M. W. Gaber and B. N. N. Achar, Phys. Rev. B52, 1314(1995)) of quantum tunneling of damped flux lines of finite mass has been extended over the temperature range from the crossover temperature T0 to T=0 with a view to investigate further the temperature dependence of the tunneling rate found earlier. It has been found that at T=0, for the case of the cubic pinning potential, the action can be evaluated in a closed form for a flux line of finite length. The only non-zero contribution arises from the dissipation term resulting in a finite action.

Double soft graviton theorems and Bondi-Metzner-Sachs symmetries

NASA Astrophysics Data System (ADS)

Anupam, A. H.; Kundu, Arpan; Ray, Krishnendu

2018-05-01

It is now well understood that Ward identities associated with the (extended) BMS algebra are equivalent to single soft graviton theorems. In this work, we show that if we consider nested Ward identities constructed out of two BMS charges, a class of double soft factorization theorems can be recovered. By making connections with earlier works in the literature, we argue that at the subleading order, these double soft graviton theorems are the so-called consecutive double soft graviton theorems. We also show how these nested Ward identities can be understood as Ward identities associated with BMS symmetries in scattering states defined around (non-Fock) vacua parametrized by supertranslations or superrotations.

Photometry and polarimetry of V 1057 Cygni.

NASA Technical Reports Server (NTRS)

Rieke, G.; Lee, T.; Coyne, G.

1972-01-01

Evaluation of extensive photometric and polarimetric data over a six-month interval for V 1057 Cyg. The polarization appears to be constant and of interstellar origin; the photometry, which extends nearly six octaves from the ultraviolet to 22 microns in the infrared, indicates that the total observed luminosity is decreasing - having now declined about 10% from its earlier level. A model characterized by two circumstellar shells which absorb and reradiate short-wavelength stellar flux from an underlying A1-type star provides the best fit to the observational data. The present variability, however, cannot be due to circumstellar activity, but appears to originate in the star itself.

On the Geometry of Chemical Reaction Networks: Lyapunov Function and Large Deviations

NASA Astrophysics Data System (ADS)

Agazzi, A.; Dembo, A.; Eckmann, J.-P.

2018-04-01

In an earlier paper, we proved the validity of large deviations theory for the particle approximation of quite general chemical reaction networks. In this paper, we extend its scope and present a more geometric insight into the mechanism of that proof, exploiting the notion of spherical image of the reaction polytope. This allows to view the asymptotic behavior of the vector field describing the mass-action dynamics of chemical reactions as the result of an interaction between the faces of this polytope in different dimensions. We also illustrate some local aspects of the problem in a discussion of Wentzell-Freidlin theory, together with some examples.

CRUSTAL REFRACTION PROFILE OF THE LONG VALLEY CALDERA, CALIFORNIA, FROM THE JANUARY 1983 MAMMOTH LAKES EARTHQUAKE SWARM.

USGS Publications Warehouse

Luetgert, James H.; Mooney, Walter D.

1985-01-01

Seismic-refraction profiles recorded north of Mammoth Lakes, California, using earthquake sources from the January 1983 swarm complement earlier explosion refraction profiles and provide velocity information from deeper in the crust in the area of the Long Valley caldera. Eight earthquakes from a depth range of 4. 9 to 8. 0 km confirm the observation of basement rocks with seismic velocities ranging from 5. 8 to 6. 4 km/sec extending at least to depths of 20 km. The data provide further evidence for the existence of a partial melt zone beneath Long Valley caldera and constrain its geometry. Refs.

IRAS observations of chromospherically active dwarf stars

NASA Technical Reports Server (NTRS)

Tsikoudi, Vassiliki

1989-01-01

Far-infrared observations of chromospherically active, spotted, and plage stars in the dF7-dk7 spectral range are examined. Most (75 percent) of the stars have detectable 12-micron fluxes, and 50 percent of them have 25-micron emission. The 12-micron luminosity, L(12), is found to be in the range of 1.5-13 x 10 to the 30th ergs/s and to comprise only 0.2-0.5 percent of the star's total luminosity, L(bol). The present work extends to earlier spectral types and higher stellar luminosities the L(12) vs L(bol) relationship noted previously for late-type active dwarfs (K5-M5).

Effect of ram semen extenders and supplements on computer assisted sperm analysis parameters

USDA-ARS?s Scientific Manuscript database

A study evaluated the effects of ram semen extender and extender supplementation on computer assisted sperm analysis (CASA) parameters positively correlated with progressive motility. Semen collected from 5 rams was distributed across treatment combinations consisting of either TRIS citrate (T) or ...

Long-term ice phenology records from eastern-central Europe

NASA Astrophysics Data System (ADS)

Takács, Katalin; Kern, Zoltán; Pásztor, László

2018-03-01

A dataset of annual freshwater ice phenology was compiled for the largest river (Danube) and the largest lake (Lake Balaton) in eastern-central Europe, extending regular river and lake ice monitoring data through the use of historical observations and documentary records dating back to AD 1774 and AD 1885, respectively. What becomes clear is that the dates of the first appearance of ice and freeze-up have shifted, arriving 12-30 and 4-13 days later, respectively, per 100 years. Break-up and ice-off have shifted to earlier dates by 7-13 and 9-27 days/100 years, except on Lake Balaton, where the date of break-up has not changed significantly. The datasets represent a resource for (paleo)climatological research thanks to the strong, physically determined link between water and air temperature and the occurrence of freshwater ice phenomena. The derived centennial records of freshwater cryophenology for the Danube and Balaton are readily available for detailed analysis of the temporal trends, large-scale spatial comparison, or other climatological purposes. The derived dataset is publicly available via PANGAEA at https://doi.org/10.1594/PANGAEA.881056.

Himalayan fossils of the oldest known pantherine establish ancient origin of big cats.

PubMed

Tseng, Z Jack; Wang, Xiaoming; Slater, Graham J; Takeuchi, Gary T; Li, Qiang; Liu, Juan; Xie, Guangpu

2014-01-07

Pantherine felids ('big cats') include the largest living cats, apex predators in their respective ecosystems. They are also the earliest diverging living cat lineage, and thus are important for understanding the evolution of all subsequent felid groups. Although the oldest pantherine fossils occur in Africa, molecular phylogenies point to Asia as their region of origin. This paradox cannot be reconciled using current knowledge, mainly because early big cat fossils are exceedingly rare and fragmentary. Here, we report the discovery of a fossil pantherine from the Tibetan Himalaya, with an age of Late Miocene-Early Pliocene, replacing African records as the oldest pantherine. A 'total evidence' phylogenetic analysis of pantherines indicates that the new cat is closely related to the snow leopard and exhibits intermediate characteristics on the evolutionary line to the largest cats. Historical biogeographic models provide robust support for the Asian origin of pantherines. The combined analyses indicate that 75% of the divergence events in the pantherine lineage extended back to the Miocene, up to 7 Myr earlier than previously estimated. The deeper evolutionary origin of big cats revealed by the new fossils and analyses indicate a close association between Tibetan Plateau uplift and diversification of the earliest living cats.

Nearwork-induced changes in lenticular thickness in different refractive groups.

PubMed

Vasudevan, Balamurali; Ciuffreda, Kenneth J

2011-11-01

The aim of this study was to directly measure lenticular thickness and its additivity after 1 and 2 hours of continuous reading at near in myopic and emmetropic young adults. Thirty-five subjects consisting of 12 early-onset myopes, 11 late-onset myopes, and 12 emmetropes were tested. Axial lenticular thickness was measured in the right eye using A-scan ultrasonography before and immediately after 1 and 2 hours of continuous reading at near (35 to 40 cm). Group mean (±SD) changes in lenticular thickness from baseline values after the first and second hours of reading were 0.025 ± 0.011 and 0.035 ± 0.017 mm, respectively. The group mean increase in lenticular thickness after the second hour was significantly larger than after the first hour, with subsequent subgroup analysis indicating that this was found in the myopes only. The lenticular increase was additive in nature, but only in the late-onset and early-onset myopes. This confirmed and extended objectively earlier studies that suggested increased nearwork accommodative susceptibility of a primarily lenticular nature in myopes. Copyright © 2011 American Optometric Association. Published by Elsevier Inc. All rights reserved.

Some See It, Some Don’t: Exploring the Relation between Inattentional Blindness and Personality Factors

PubMed Central

Kreitz, Carina; Schnuerch, Robert; Gibbons, Henning; Memmert, Daniel

2015-01-01

Human awareness is highly limited, which is vividly demonstrated by the phenomenon that unexpected objects go unnoticed when attention is focused elsewhere (inattentional blindness). Typically, some people fail to notice unexpected objects while others detect them instantaneously. Whether this pattern reflects stable individual differences is unclear to date. In particular, hardly anything is known about the influence of personality on the likelihood of inattentional blindness. To fill this empirical gap, we examined the role of multiple personality factors, namely the Big Five, BIS/BAS, absorption, achievement motivation, and schizotypy, in these failures of awareness. In a large-scale sample (N = 554), susceptibility to inattentional blindness was associated with a low level of openness to experience and marginally with a low level of achievement motivation. However, in a multiple regression analysis, only openness emerged as an independent, negative predictor. This suggests that the general tendency to be open to experience extends to the domain of perception. Our results complement earlier work on the possible link between inattentional blindness and personality by demonstrating, for the first time, that failures to consciously perceive unexpected objects reflect individual differences on a fundamental dimension of personality. PMID:26011567

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mukherji, Debashish; Stuehn, Torsten; Kremer, Kurt

Smart polymers are a modern class of polymeric materials that often exhibit unpredictable behavior in mixtures of solvents. One such phenomenon is co-non-solvency. Co-non-solvency occurs when two (perfectly) miscible and competing good solvents, for a given polymer, are mixed together. As a result, the same polymer collapses into a compact globule within intermediate mixing ratios. More interestingly, polymer collapses when the solvent quality remains good and even gets increasingly better by the addition of the better cosolvent. This is a puzzling phenomenon that is driven by strong local concentration fluctuations. Because of the discrete particle based nature of the interactions,more » Flory-Huggins type mean field arguments become unsuitable. In this work, we extend the analysis of the co-non-solvency effect presented earlier [D. Mukherji et al., Nat. Commun. 5, 4882 (2014)]. We explain why co-non-solvency is a generic phenomenon, which can only be understood by the thermodynamic treatment of the competitive displacement of (co)solvent components. This competition can result in a polymer collapse upon improvement of the solvent quality. Specific chemical details are not required to understand these complex conformational transitions. Therefore, a broad range of polymers are expected to exhibit similar reentrant coil-globule-coil transitions in competing good solvents.« less

Role of multiple cusps in tooth fracture.

PubMed

Barani, Amir; Bush, Mark B; Lawn, Brian R

2014-07-01

The role of multiple cusps in the biomechanics of human molar tooth fracture is analysed. A model with four cusps at the bite surface replaces the single dome structure used in previous simulations. Extended finite element modelling, with provision to embed longitudinal cracks into the enamel walls, enables full analysis of crack propagation from initial extension to final failure. The cracks propagate longitudinally around the enamel side walls from starter cracks placed either at the top surface (radial cracks) or from the tooth base (margin cracks). A feature of the crack evolution is its stability, meaning that extension occurs steadily with increasing applied force. Predictions from the model are validated by comparison with experimental data from earlier publications, in which crack development was followed in situ during occlusal loading of extracted human molars. The results show substantial increase in critical forces to produce longitudinal fractures with number of cuspal contacts, indicating a capacity for an individual tooth to spread the load during mastication. It is argued that explicit critical force equations derived in previous studies remain valid, at the least as a means for comparing the capacity for teeth of different dimensions to sustain high bite forces. Copyright © 2014 Elsevier Ltd. All rights reserved.

Examining deterrence of adult sex crimes: A semi-parametric intervention time series approach.

PubMed

Park, Jin-Hong; Bandyopadhyay, Dipankar; Letourneau, Elizabeth

2014-01-01

Motivated by recent developments on dimension reduction (DR) techniques for time series data, the association of a general deterrent effect towards South Carolina (SC)'s registration and notification (SORN) policy for preventing sex crimes was examined. Using adult sex crime arrestee data from 1990 to 2005, the the idea of Central Mean Subspace (CMS) is extended to intervention time series analysis (CMS-ITS) to model the sequential intervention effects of 1995 (the year SC's SORN policy was initially implemented) and 1999 (the year the policy was revised to include online notification) on the time series spectrum. The CMS-ITS model estimation was achieved via kernel smoothing techniques, and compared to interrupted auto-regressive integrated time series (ARIMA) models. Simulation studies and application to the real data underscores our model's ability towards achieving parsimony, and to detect intervention effects not earlier determined via traditional ARIMA models. From a public health perspective, findings from this study draw attention to the potential general deterrent effects of SC's SORN policy. These findings are considered in light of the overall body of research on sex crime arrestee registration and notification policies, which remain controversial.

Dressing disrupted: negotiating care through the materiality of dress in the context of dementia.

PubMed

Buse, Christina; Twigg, Julia

2018-02-01

This paper explores how the materiality of dress mediates and shapes practices of care in the context of dementia. Earlier research called for an approach to conceptualising care that recognised the role played by everyday artefacts. We extend this to a consideration of dress and dressing the body in relation to people with dementia that involves the direct manipulation of material objects, as well as the materiality of bodies. The paper draws on an ESRC funded study Dementia and Dress, which examined experiences of dress for people with dementia, families and care-workers using ethnographic and qualitative methods. Our analysis explores the process of dressing the body, the physicality of guiding and manipulating bodies into clothing, dealing with fabrics and bodies which 'act back' and are resistant to the process of dressing. We consider how the materiality of clothing can constrain or enable practices of care, exploring tensions between garments that support ease of dressing and those that sustain identity. Examining negotiations around dress also reveals tensions between competing 'logics' of care (Mol ). © 2018 The Authors. Sociology of Health & Illness published by John Wiley & Sons Ltd on behalf of Foundation for SHIL.

Global CALIPSO Observations of Aerosol Changes Near Clouds

NASA Technical Reports Server (NTRS)

Varnai, Tamas; Marshak, Alexander

2011-01-01

Several recent studies have found that clouds are surrounded by a transition zone of rapidly changing aerosol optical properties and particle size. Characterizing this transition zone is important for better understanding aerosol-cloud interactions and aerosol radiative effects, and also for improving satellite retrievals of aerosol properties. This letter presents a statistical analysis of a monthlong global data set of Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) lidar observations over oceans. The results show that the transition zone is ubiquitous over all oceans and extends up to 15 km away from clouds. They also show that near-cloud enhancements in backscatter and particle size are strongest at low altitudes, slightly below the top of the nearest clouds. Also, the enhancements are similar near illuminated and shadowy cloud sides, which confirms that the asymmetry of Moderate Resolution Imaging Spectroradiometer reflectances found in an earlier study comes from 3-D radiative processes and not from differences in aerosol properties. Finally, the effects of CALIPSO aerosol detection and cloud identification uncertainties are discussed. The findings underline the importance of accounting for the transition zone to avoid potential biases in studies of satellite aerosol products, aerosol-cloud interactions, and aerosol direct radiative effects.

VizieR Online Data Catalog: A deep Chandra ACIS survey of M83 (Long+, 2014)

NASA Astrophysics Data System (ADS)

Long, K. S.; Kuntz, K. D.; Blair, W. P.; Godfrey, L.; Plucinsky, P. P.; Soria, R.; Stockdale, C.; Winkler, P. F.

2014-07-01

X-ray observations of M83 were all carried out with Chandra/ACIS-S in the "very faint" mode and spaced over a period of one year from 2010 December to 2011 December. We included in our analysis earlier Chandra observations of M83 in 2000 and 2001 totaling 61ks obtained by G. Rieke (Prop ID. 1600489; ObsID 73) and by A. Prestwich (Prop ID. 267005758; ObsID 2064). To support and extend our X-ray study of M83, we have been carrying out a number of other studies of M83, including optical broadband and narrowband imaging with the IMACS camera on Magellan (Blair et al. 2012, Cat. J/ApJS/203/8), optical imaging with the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST; W. P. Blair PI, Prop. ID. 12513, Blair et al. 2014ApJ...788...55B), and radio imaging with the Jansky Very Large Array (JVLA; C. Stockdale PI, Prog. ID. 12A-335). Here we describe new 6 and 3cm radio imaging we have obtained from ATCA (Australia Telescope Compact Array) on 2011 April 28, 29, and 30 (table 2). (4 data files).

Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice

PubMed Central

Esibizione, Diana; Cui, Chang-Yi; Schlessinger, David

2009-01-01

EDA, the gene mutated in anhidrotic ectodermal dysplasia, encodes ectodysplasin, a TNF superfamily member that activates NF-kB mediated transcription. To identify EDA target genes, we have earlier used expression profiling to infer genes differentially expressed at various developmental time points in Tabby (Eda-deficient) compared to wild-type mouse skin. To increase the resolution to find genes whose expression may be restricted to epidermal cells, we have now extended studies to primary keratinocyte cultures established from E19 wild-type and Tabby skin. Using microarrays bearing 44,000 gene probes, we found 385 preliminary candidate genes whose expression was significantly affected by Eda loss. By comparing expression profiles to those from Eda-A1 transgenic skin, we restricted the list to 38 “candidate EDA targets”, 14 of which were already known to be expressed in hair follicles or epidermis. We confirmed expression changes for 3 selected genes, Tbx1, Bmp7, and Jag1, both in keratinocytes and in whole skin, by Q-PCR and Western blotting analyses. Thus, by the analysis of keratinocytes, novel candidate pathways downstream of EDA were detected. PMID:18848976

Structure and kinematics of a major tectonic contact, Michipicoten greenstone belt, Ontario

NASA Technical Reports Server (NTRS)

Mcgill, George E.

1992-01-01

The Michipicoten greenstone belt, Ontario, experienced a complex history of folding, faulting, and fabric development. Near Wawa, a major east-west contact, here named the Steep Hill Falls (SHF) contact, extends entirely across the belt. The SHF contact is both an angular unconformity and a fault and is interpreted to be a regionally significant tectonic contact separating distinct northern and southern terranes, both of which include volcanic rocks of probable island-arc origin. The amount of horizontal transport involved in bringing the two terranes together along the SHF contact is not known. Mapping and structural analysis suggest that regionally significant horizontal displacements took place, with movement vectors that changed with time. Early faults, folds, and fabrics imply north-south to northeast-southwest (with respect to present directions) convergence, with a vergence reversal occurring during this complex event. The most likely models infer early south vergence and later north vergence. Transecting the earliest structures are younger (but still Archean) northeast-striking steep cleavages with associated upright folds that may relate to northwest-southeast assembly of the Superior Province craton. The craton assembly event thus involved a transport direction at a high angle to that inferred for the earlier assembly of the Michipicoten greenstone belt.

Analysis of semiclassical approximations in the framework of quantumhadrodynamics

NASA Astrophysics Data System (ADS)

Speicher, C.; Engel, E.; Dreizler, R. M.

1993-10-01

We examine the importance of gradient corrections to the Thomas-Fermi (TF) approximation for the description of semi-infinite nuclear matter and nuclei within the framework of quantumhadrodynamics. The discussion of semi-infinite nuclear matter exhibits most clearly how surface properties depend on the parametrisation of the effective interaction. In agreement with earlier studies it is found that for parametrisations with low effective mass the original extended TF (ETF) equations cannot be solved. We present a scheme to overcome this problem which is very much in the spirit of the semiclassical approach and allows for a solution in any situation. For the case of nuclei the results of the TF and ETF approximations are compared to those of Hartree calculations which serve as a standard in this context. In accordance with the sensitivity of semi-infinite nuclear matter results to the specific parametrisation, ETF does not yield a consistent improvement over TF for all parametrisations. However, by examining a larger number of parametrisations it is shown that those cases where TF results are closer to Hartree data have to be regarded as fortuitous and that on average the agreement between ETF and Hartree results is clearly better.

A mathematical model for maximizing the value of phase 3 drug development portfolios incorporating budget constraints and risk.

PubMed

Patel, Nitin R; Ankolekar, Suresh; Antonijevic, Zoran; Rajicic, Natasa

2013-05-10

We describe a value-driven approach to optimizing pharmaceutical portfolios. Our approach incorporates inputs from research and development and commercial functions by simultaneously addressing internal and external factors. This approach differentiates itself from current practices in that it recognizes the impact of study design parameters, sample size in particular, on the portfolio value. We develop an integer programming (IP) model as the basis for Bayesian decision analysis to optimize phase 3 development portfolios using expected net present value as the criterion. We show how this framework can be used to determine optimal sample sizes and trial schedules to maximize the value of a portfolio under budget constraints. We then illustrate the remarkable flexibility of the IP model to answer a variety of 'what-if' questions that reflect situations that arise in practice. We extend the IP model to a stochastic IP model to incorporate uncertainty in the availability of drugs from earlier development phases for phase 3 development in the future. We show how to use stochastic IP to re-optimize the portfolio development strategy over time as new information accumulates and budget changes occur. Copyright © 2013 John Wiley & Sons, Ltd.

Networked Instructional Chemistry: Using Technology To Teach Chemistry

NASA Astrophysics Data System (ADS)

Smith, Stanley; Stovall, Iris

1996-10-01

Networked multimedia microcomputers provide new ways to help students learn chemistry and to help instructors manage the learning environment. This technology is used to replace some traditional laboratory work, collect on-line experimental data, enhance lectures and quiz sections with multimedia presentations, provide prelaboratory training for beginning nonchemistry- major organic laboratory, provide electronic homework for organic chemistry students, give graduate students access to real NMR data for analysis, and provide access to molecular modeling tools. The integration of all of these activities into an active learning environment is made possible by a client-server network of hundreds of computers. This requires not only instructional software but also classroom and course management software, computers, networking, and room management. Combining computer-based work with traditional course material is made possible with software management tools that allow the instructor to monitor the progress of each student and make available an on-line gradebook so students can see their grades and class standing. This client-server based system extends the capabilities of the earlier mainframe-based PLATO system, which was used for instructional computing. This paper outlines the components of a technology center used to support over 5,000 students per semester.

Estimation of flow properties using surface deformation and head data: A trajectory-based approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vasco, D.W.

2004-07-12

A trajectory-based algorithm provides an efficient and robust means to infer flow properties from surface deformation and head data. The algorithm is based upon the concept of an ''arrival time'' of a drawdown front, which is defined as the time corresponding to the maximum slope of the drawdown curve. The technique involves three steps: the inference of head changes as a function of position and time, the use of the estimated head changes to define arrival times, and the inversion of the arrival times for flow properties. Trajectories, computed from the output of a numerical simulator, are used to relatemore » the drawdown arrival times to flow properties. The inversion algorithm is iterative, requiring one reservoir simulation for each iteration. The method is applied to data from a set of 14 tiltmeters, located at the Raymond Quarry field site in California. Using the technique, I am able to image a high-conductivity channel which extends to the south of the pumping well. The presence of th is permeable pathway is supported by an analysis of earlier cross-well transient pressure test data.« less

Discriminating the effects of spatial extent and population size in cyclic competition among species

NASA Astrophysics Data System (ADS)

Lamouroux, David; Eule, Stephan; Geisel, Theo; Nagler, Jan

2012-02-01

Quantifying and understanding the stability and biodiversity of ecosystems is a major task in biological physics as well as in theoretical ecology. From the perspective of game theory, this is highly relevant for questions pertaining to the emergence of cooperation or the coexistence of cyclically competing species. The latter has been recently proposed as a paradigm for biodiversity and it has been shown that the mobility of individuals can support the stability of biodiversity by the formation of spirals. In this contribution, we present a population model for species under cyclic competition that extends earlier lattice models to allow the single cells to accommodate more than one individual by introducing a per cell carrying capacity. We confirm that the emergence of spirals induce a transition from an unstable to a stable regime. This transition however does not appear to be sharp and we find a broad intermediate regime that exhibits an ambiguous behavior. The separation of the two regimes by the usual scaling analysis is thus hampered. The newly introduced carrying capacity offers an alternative way of characterizing the transition. We thus overcome the original limitations by separately analyzing the effect of spatial extent and population size.

Analysis of syntactic foam – GFRP sandwich composites for flexural loads

NASA Astrophysics Data System (ADS)

Paul, Daniel; Velmurugan, R.; Jayaganthan, R.; Gupta, N. K.; Manzhirov, A. V.

2018-04-01

The use of glass microballoon (GMB) — epoxy syntactic foams as a sandwich core material is studied. The skins and foam core are fabricated and joined instantaneously unlike the procedures followed in the previous studies. Each successive layer of the sandwich is fabricated when the previous layer is in a semi-gelled state. These sandwich samples are characterized for their properties under flexural loading. The failure modes and mechanical properties are carefully investigated. The change in fabrication technique results in a significant increase in the load bearing pattern of the sandwich. In earlier studies, debonding was found to occur prematurely since the bonding between the skins and core is the weakest plane. Using the current technique, core cracking occurs first, followed by skin fiber breaking and debonding happens at the end. This ensures that the load carrying phase of the structure is extended considerably. The sandwich is also analytically studied using Reddy’s higher order shear deformation theory. A higher order theory is selected as the sandwich can no longer be considered as a thin beam and thus shear effects also need to be considered in addition to bending effects.

Quasibiennial Oscillation in Tropical Ozone as Revealed by Ozonesonde and Satellite Data

NASA Technical Reports Server (NTRS)

Logan, J. A.; Jones, D. B. A.; Megretskaia, I. A.; Oltmans, S. J.; Johnson, B. J.; Voemel, H.; Randel, W. J.; Kimani, W.; Schmidlin, F. J.

2003-01-01

We present an analysis of the quasi-biennial oscillation (QBO) in tropical ozone using recent in situ measurements made by ozonesondes, supplemented by satellite profile and column data. The first in situ equatorial ozone profiles reveal the dramatic change in shape of the profile that accompanies the descent of the westerly shear zone. The partial pressure maximum in ozone increases by -25% in 5-6 months as it descends from 17.5 to 24 hPa. The amplitude of the QBO anomaly that extends from 15 to 80 hPa is found to exceed *20%, larger than indicated by earlier analyses of satellite data. The influence of the QBO on equatorial ozone is dominant between 10 and 45 hPa, but the seasonal cycle is more important below 50 hPa. The equatorial ozone anomalies are influenced by El Niiio-Southern Oscillation (ENSO) in the lowest part of the stratosphere. The ozone anomaly in the lower stratosphere at 20"s lags that at the equator by only a few months during the easterlies from 1994 to 1998, contrary to the previous picture of the subtropical and equatorial anomalies being out of phase.

A MODIFIED PROTEIN ASSAY FROM MICROGRAM TO LOW NANOGRAM LEVELS IN DILUTE SAMPLES

PubMed Central

Heda, Ghanshyam D.; Kunwar, Upasana; Heda, Rajiv P.

2013-01-01

In this paper we present a modified and improved protein assay that was previously described as ‘amidoschwarz assay’ by Schaffner and Weissmann (Anal. Biochem. 56, 1973, 502–514). Our improved protein assay is user-friendly and 30 to 40 times more sensitive than the earlier method. The assay was developed into 3 formats (maco, micro, and nanoassay) with TCA as protein precipitating agent; measuring up to 96 samples. The macro and micro formats of this assay require a single reagent staining with amido black of protein dots, bound to nitrocellulose membrane with lowest protein measurements to 1 μg and 0.1 μg respectively. The nanoassay on the other hand with combination staining of amido black followed by colloidal gold can extend the detection limit to 2.5 ng of protein. Protein concentrations were determined by densitometry and/or spectrophotometry. This assay is compatible with many ionic and non-ionic detergents. This improved protein assay provides an additional choice to researchers in measuring total protein concentration accurately in dilute biological samples as low as 0.125 μg/ml, prior to their biochemical analysis such as in comparative proteomics. PMID:24135655

Three dimensional finite temperature SU(3) gauge theory near the phase transition

NASA Astrophysics Data System (ADS)

Bialas, P.; Daniel, L.; Morel, A.; Petersson, B.

2013-06-01

We have measured the correlation function of Polyakov loops on the lattice in three dimensional SU(3) gauge theory near its finite temperature phase transition. Using a new and powerful application of finite size scaling, we furthermore extend the measurements of the critical couplings to considerably larger values of the lattice sizes, both in the temperature and space directions, than was investigated earlier in this theory. With the help of these measurements we perform a detailed finite size scaling analysis, showing that for the critical exponents of the two dimensional three state Potts model the mass and the susceptibility fall on unique scaling curves. This strongly supports the expectation that the gauge theory is in the same universality class. The Nambu-Goto string model on the other hand predicts that the exponent ν has the mean field value, which is quite different from the value in the abovementioned Potts model. Using our values of the critical couplings we also determine the continuum limit of the value of the critical temperature in terms of the square root of the zero temperature string tension. This value is very near to the prediction of the Nambu-Goto string model in spite of the different critical behaviour.

Determinants of First-Time Cancer Examinations in a Rural Community: A Mechanism for Behavior Change

PubMed Central

Guo, Yi; Emanuel, Amber S.; Shepperd, James A.; Dodd, Virginia J.; Marks, John G.; Muller, Keith E.; Riley, Joseph L.

2015-01-01

Objectives. After conducting a media campaign focusing on the importance of oral and pharyngeal cancer (OPC) examinations, we assessed mechanisms of behavior change among individuals receiving an OPC examination for the first time. Methods. We used data from 2 waves of telephone surveys of individuals residing in 36 rural census tracts in northern Florida (n = 806). The second survey occurred after our media intervention. We developed media messages and modes of message delivery with community members via focus groups and intercept interviews. We performed a mediation analysis to examine behavior change mechanisms. Results. Greater exposure to media messages corresponded with heightened concern about OPC. Heightened concern, in turn, predicted receipt of a first-time OPC examination, but only among men. Conclusions. We extended earlier studies by measuring an outcome behavior (receipt of an OPC examination) and demonstrating that the putative mechanism of action (concern about the disease) explained the link between a media intervention and engaging in the target behavior. Improving the quality of media campaigns by engaging community stakeholders in selecting messages and delivery methods is an effective strategy in building public health interventions aimed at changing behaviors. PMID:25973820

Review of extended producer responsibility: A case study approach.

PubMed

Gupt, Yamini; Sahay, Samraj

2015-07-01

Principles of extended producer responsibility have been the core of most of the recent policies and legislation dealing with the end-of-life management of recyclable goods. This article makes an exploratory review of 27 cases of extended producer responsibility from developed and developing economies with and without informal recycling, to ascertain the most important aspect of extended producer responsibility. A comparative analysis of the cases with respect to role of stakeholders in the upstream and downstream stages of the extended producer responsibility has been carried out. Further, the study uses exploratory factor analysis to determine the important aspects of the extended producer responsibility in practice using 13 variables identified from the review. Findings of the comparative analysis reveal that financial responsibility of the producers and separate collecting and recycling agencies contributed significantly to the success of the extended producer responsibility-based environmental policies. Regulatory provisions, take-back responsibility and financial flow come out to be the three most important aspects of the extended producer responsibility. Presence of informal sector had a negative impact on the regulatory provisions. The outcomes of this study could serve as a guideline for designing of effective extended producer responsibility-based policies. © The Author(s) 2015.

Leisure-Time and Occupational Physical Activity in Early and Late Adulthood in Relation to Later Life Physical Functioning.

PubMed

Kulmala, Jenni; Ngandu, Tiia; Pajala, Satu; Lehtisalo, Jenni; Levälahti, Esko; Antikainen, Riitta; Laatikainen, Tiina; Oksa, Heikki; Peltonen, Markku; Rauramaa, Rainer; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia

2016-10-01

Physical activity (PA) has beneficial effects on older age physical functioning, but longitudinal studies with follow-ups extending up to decades are few. We investigated the association between leisure-time PA (LTPA) and occupational PA (OPA) from early to late adulthood in relation to later life performance-based physical functioning. The study involved 1260 people aged 60 to 79 years who took part in assessments of physical functioning (Short Physical Performance Battery [SPPB] test, 10-m maximal walking test, and grip strength test). Participants' data on earlier life LTPA/OPA (age range 25 to 74 years) were received from the previous studies (average follow-up 13.4 years). Logistic, linear, and censored regression models were used to assess the associations between LTPA/OPA earlier in life and subsequent physical functioning. A high level of LTPA earlier in life was associated with a lower risk of having difficulties on the SPPB test (odds ratio [OR]: 0.37; 95% confidence interval [CI], 0.24-0.58) and especially on the chair rise test (OR: 0.42; 95% CI, 0.27-0.64) in old age. Heavy manual work predicted difficulties on SPPB (OR: 1.91; 95% CI, 1.22-2.98) and the chair rise test (OR: 1.75; 95% CI, 1.14-2.69) and poorer walking speed (β = .10, P = .005). This study highlights the importance of LTPA on later life functioning, but also indicates the inverse effects that may be caused by heavy manual work.

Effects of sea ice cover on satellite-detected primary production in the Arctic Ocean

PubMed Central

Lee, Zhongping; Mitchell, B. Greg; Nevison, Cynthia D.

2016-01-01

The influence of decreasing Arctic sea ice on net primary production (NPP) in the Arctic Ocean has been considered in multiple publications but is not well constrained owing to the potentially large errors in satellite algorithms. In particular, the Arctic Ocean is rich in coloured dissolved organic matter (CDOM) that interferes in the detection of chlorophyll a concentration of the standard algorithm, which is the primary input to NPP models. We used the quasi-analytic algorithm (Lee et al. 2002 Appl. Opti. 41, 5755−5772. (doi:10.1364/AO.41.005755)) that separates absorption by phytoplankton from absorption by CDOM and detrital matter. We merged satellite data from multiple satellite sensors and created a 19 year time series (1997–2015) of NPP. During this period, both the estimated annual total and the summer monthly maximum pan-Arctic NPP increased by about 47%. Positive monthly anomalies in NPP are highly correlated with positive anomalies in open water area during the summer months. Following the earlier ice retreat, the start of the high-productivity season has become earlier, e.g. at a mean rate of −3.0 d yr−1 in the northern Barents Sea, and the length of the high-productivity period has increased from 15 days in 1998 to 62 days in 2015. While in some areas, the termination of the productive season has been extended, owing to delayed ice formation, the termination has also become earlier in other areas, likely owing to limited nutrients. PMID:27881759

A child-centred exploration of the relevance of family and friends to theory of mind development.

PubMed

Wright, Barlow C; Mahfoud, Janina

2012-02-01

Theory of Mind (ToM) is said to develop at around 4 years old. But some studies suggest it develops considerably earlier than this, with others suggesting it develops much later. Although several recent studies have found that social factors (like gender, family size, number of siblings, and number of friends) can impact on ToM, other studies contradict those findings. We wondered whether addressing several procedural issues and ensuring the task concerns real protagonists in real time, would bear on the above issues. Here, 114 children of 3-6 years completed four ToM tasks incorporating controls from experimental psychology, including randomly varying the order of ToM and non-ToM questions across participants. Now, children passed ToM tasks from around 5 years old, rather than 4 years or earlier. Girls did not develop ToM any earlier than boys. There was clear correlational evidence for the older-sibling effect and effects of friends but no reliable effects of nuclear or extended family. However, when these factors were set in the context of one another, the sibling effect was driven by a negative influence from younger siblings (as opposed to older siblings) and the friends effect was driven by friends at school (as opposed to friends at home). Finally, "friends" was a stronger predictor than siblings but memory (a cognitive factor) and age (a maturational factor) were the strongest predictors of all. © 2011 The Authors. Scandinavian Journal of Psychology © 2011 The Scandinavian Psychological Associations.

Effects of sea ice cover on satellite-detected primary production in the Arctic Ocean.

PubMed

Kahru, Mati; Lee, Zhongping; Mitchell, B Greg; Nevison, Cynthia D

2016-11-01

The influence of decreasing Arctic sea ice on net primary production (NPP) in the Arctic Ocean has been considered in multiple publications but is not well constrained owing to the potentially large errors in satellite algorithms. In particular, the Arctic Ocean is rich in coloured dissolved organic matter (CDOM) that interferes in the detection of chlorophyll a concentration of the standard algorithm, which is the primary input to NPP models. We used the quasi-analytic algorithm (Lee et al 2002 Appl. Opti. 41, 5755-5772. (doi:10.1364/AO.41.005755)) that separates absorption by phytoplankton from absorption by CDOM and detrital matter. We merged satellite data from multiple satellite sensors and created a 19 year time series (1997-2015) of NPP. During this period, both the estimated annual total and the summer monthly maximum pan-Arctic NPP increased by about 47%. Positive monthly anomalies in NPP are highly correlated with positive anomalies in open water area during the summer months. Following the earlier ice retreat, the start of the high-productivity season has become earlier, e.g. at a mean rate of -3.0 d yr -1 in the northern Barents Sea, and the length of the high-productivity period has increased from 15 days in 1998 to 62 days in 2015. While in some areas, the termination of the productive season has been extended, owing to delayed ice formation, the termination has also become earlier in other areas, likely owing to limited nutrients. © 2016 The Author(s).

Physics Metacognition Inventory Part Ii: Confirmatory Factor Analysis and Rasch Analysis

ERIC Educational Resources Information Center

Taasoobshirazi, Gita; Bailey, MarLynn; Farley, John

2015-01-01

The Physics Metacognition Inventory was developed to measure physics students' metacognition for problem solving. In one of our earlier studies, an exploratory factor analysis provided evidence of preliminary construct validity, revealing six components of students' metacognition when solving physics problems including knowledge of cognition,…

Life-threatening motor vehicle crashes in bright sunlight

PubMed Central

Redelmeier, Donald A.; Raza, Sheharyar

2017-01-01

Abstract Bright sunlight may create visual illusions that lead to driver error, including fallible distance judgment from aerial perspective. We tested whether the risk of a life-threatening motor vehicle crash was increased when driving in bright sunlight. This longitudinal, case-only, paired-comparison analysis evaluated patients hospitalized because of a motor vehicle crash between January 1, 1995 and December 31, 2014. The relative risk of a crash associated with bright sunlight was estimated by evaluating the prevailing weather at the time and place of the crash compared with the weather at the same hour and location on control days a week earlier and a week later. The majority of patients (n = 6962) were injured during daylight hours and bright sunlight was the most common weather condition at the time and place of the crash. The risk of a life-threatening crash was 16% higher during bright sunlight than normal weather (95% confidence interval: 9–24, P < 0.001). The increased risk was accentuated in the early afternoon, disappeared at night, extended to patients with different characteristics, involved crashes with diverse features, not apparent with cloudy weather, and contributed to about 5000 additional patient-days in hospital. The increased risk extended to patients with high crash severity as indicated by ambulance involvement, surgical procedures, length of hospital stay, intensive care unit admission, and patient mortality. The increased risk was not easily attributed to differences in alcohol consumption, driving distances, or anomalies of adverse weather. Bright sunlight is associated with an increased risk of a life-threatening motor vehicle crash. An awareness of this risk might inform driver education, trauma staffing, and safety warnings to prevent a life-threatening motor vehicle crash. Level of evidence: Epidemiologic Study, level III. PMID:28072708