Analyzing and Critiquing the Concepts of Professional Autonomy and Accountability through the Prisms of Decentralization and Constructivist Theory

ERIC Educational Resources Information Center

Shapiro, Arthur; Koren, Andrej

2012-01-01

This analysis and synthesis explores constructs of professional autonomy and accountability using constructivist theory and practice to examine the organizational dynamics of centralization/decentralization, particularly as applied to educational organizations. Major schools of constructivist thought are explored to shed light on…

The Tragic Aspect of Teaching: Hope in Face of Uncertainty

ERIC Educational Resources Information Center

Scott, Kieran

2017-01-01

Educators throughout the ages have offered metaphors and analogies for teaching and teachers. Prominent among them are: gardener, midwife, facilitator, guide, sacrament. Each of these metaphors shed light, from a different angle, on the act of teaching. This article proposes the metaphor of tragedy as a way of shedding new light, from a totally…

The Muted Voice of the Catholic Church in Angola

DTIC Science & Technology

2016-12-01

Mozambique despite a common colonial and religious heritage. The analysis suggests that state resistance to international influence, or gatekeeping, is a...freedoms, was weaker in Angola than in Brazil and Mozambique despite a common colonial and religious heritage. The analysis suggests that state resistance...through religious evangelization. Second, this study will shed light on how and why societies institutionalize religious values. Due to advancing

Success Factors in Higher Education-Industry Collaboration: A Case Study of Collaboration in the Engineering Field

ERIC Educational Resources Information Center

Thune, Taran

2011-01-01

This paper addresses the question of what potential success factors are relevant when developing and managing higher education-business partnerships. To shed light on this question, the paper presents a review of research literature on the possible success factors in university-industry relations. To shed further light on the factors identified in…

Writing in the Ether: A Collaborative Approach to Academic Research.

ERIC Educational Resources Information Center

Winograd, David; Milton, Katherine

The purpose of this paper is to shed light on the developmental stages of academic publication collaborations through both research on the collaborative process itself, as well as through analysis of the discovery process. Using the qualitative software package, NUD*IST, the teleconferencing system, FirstClass, and standard e-mail, the study…

Styling Hawai'i in "Haole"wood: White Protagonists on a Voyage of Self Discovery

ERIC Educational Resources Information Center

Higgins, Christina; Furukawa, Gavin

2012-01-01

This article analyzes four Hollywood films set in Hawai'i to shed light on how particular languages and language varieties "style" (Auer 2007; Coupland 2007) Local/Hawaiian and mainland U.S. characters as certain kinds of people. Through an analysis of films featuring "haole" ("white, outsider") male protagonists who…

Sex Instruction and the Construction of Homosexuality in New Zealand, 1920-1965

ERIC Educational Resources Information Center

Brickell, Chris

2005-01-01

Historical analysis of sex education materials, as well as of the debates that surround them, can shed light upon the construction of sexuality in particular contexts. This article examines some of these materials and debates as a window into the construction of "homosexuality" and "the homosexual" in mid-twentieth century New…

Exploring the Multimodality of EFL Textbooks for Chinese College Students: A Comparative Study

ERIC Educational Resources Information Center

Liu, Xiqin; Qu, Dianning

2014-01-01

To explore the multimodality of two representative EFL textbook series for Chinese college students, their visual and verbal semiotic modes were compared. The target textbooks are "Experiencing English" and "New Century College English". Through multimodal discourse analysis, the study aims to shed some light on how to develop…

EFL Teachers' Conceptualizations of Their Roles through Metaphor Analysis

ERIC Educational Resources Information Center

Asmali, Mehmet; Çelik, Handan

2017-01-01

Metaphors reflect the way people think and know the world. When they are considered within teaching profession, they can be strong agents revealing teachers? beliefs about their profession. They may also explore the meaning that teachers attach to themselves. Despite their strength to shed light on how teachers conceptualize themselves, metaphor…

"Intercultural Training" in Exchange Situations for Experts and Management: A Critical Reflection

ERIC Educational Resources Information Center

Engelbert, Sonja

2004-01-01

In this paper, developments in the area of "intercultural communication" are described to shed light on the pitfalls that the author has discovered in her analysis of some of the more popular intercultural training programs, through practical applications of communication training programs and through her own personal experiences in exchange…

The "Cape Times"'s Portrayal of School Violence

ERIC Educational Resources Information Center

de Wet, Corene

2016-01-01

This study explores the "Cape Times"'s portrayal of school violence in the Western Cape (WC), South Africa, reporting on findings from a qualitative content analysis of 41 news articles retrieved from the SA Media database. The findings shed light on the victims and their victimisation, the perpetrators, as well as the context of the…

An Application of Indian Health Service Standards for Alcoholism Programs.

ERIC Educational Resources Information Center

Burns, Thomas R.

1984-01-01

Discusses Phoenix-area applications of 1981 Indian Health Service standards for alcoholism programs. Results of standard statistical techniques note areas of deficiency through application of a one-tailed z test at .05 level of significance. Factor analysis sheds further light on design of standards. Implications for revisions are suggested.…

Bridging Theory and Practice in Norwegian Teacher Education through Action Research

ERIC Educational Resources Information Center

Husebo, Dag

2012-01-01

Handling the relationship between theory and practice is seemingly an endless challenge in Norwegian teacher education, and bridging theory and practice is highlighted whenever discussions about improvement of teacher education are raised. This article contributes to this discussion by shedding new light on the relationship through an analysis of…

School Principals' Job Satisfaction: The Effects of Work Intensification

ERIC Educational Resources Information Center

Wang, Fei; Pollock, Katina; Hauseman, Cameron

2018-01-01

This study examines principals' job satisfaction in relation to their work intensification. Frederick Herzberg's two-factor theory was used to shed light on how motivating and maintenance factors affect principals' job satisfaction. Logistic multiple regressions were used in the analysis of survey data that were collected from 2,701 elementary and…

Patterns of Learning in a Sample of Adult Returners to Higher Education

ERIC Educational Resources Information Center

Anderson, Anthony; Johnston, Bill; McDonald, Alexandra

2014-01-01

This article presents empirical research exploring adult returner students' patterns of learning via qualitative analysis of a series of semi-structured interviews. Interviewees' comments shed light on the relation between patterns of learning on the one hand, and study skills, epistemological issues and attitudes to peer interaction on the other.…

Opening up "Spaces for Manoeuvre": English Teacher Perspectives on Learner Motivation

ERIC Educational Resources Information Center

Glas, Katharina

2016-01-01

This qualitative study explores teachers' perspectives on learner motivation for English in Chilean secondary schools. Drawing both on motivation theories and on concepts related to teacher cognition, autonomy and agency, the analysis of 19 semi-structured interviews with Chilean English teachers sheds light on the difficulties that many teachers…

Complete Genome of Enterobacteriaceae Bacterium Strain FGI 57, a Strain Associated with Leaf-Cutter Ant Fungus Gardens

PubMed Central

Aylward, Frank O.; Tremmel, Daniel M.; Bruce, David C.; Chain, Patrick; Chen, Amy; Walston Davenport, Karen; Detter, Chris; Han, Cliff S.; Han, James; Huntemann, Marcel; Ivanova, Natalia N.; Kyrpides, Nikos C.; Markowitz, Victor; Mavrommatis, Kostas; Nolan, Matt; Pagani, Ioanna; Pati, Amrita; Pitluck, Sam; Deshpande, Shweta; Goodwin, Lynne; Woyke, Tanja

2013-01-01

The Enterobacteriaceae bacterium strain FGI 57 was isolated from a fungus garden of the leaf-cutter ant Atta colombica. Analysis of its single 4.76-Mbp chromosome will shed light on community dynamics and plant biomass degradation in ant fungus gardens. PMID:23469353

4. Tower entrance wing, covered way, keeper's house and shed, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Tower entrance wing, covered way, keeper's house and shed, view west northwest, northeast side of wing and covered way, southeast and northeast sides of keeper's house, southwest and southeast sides of shed - Burnt Island Light Station, Burnt Island, west side of entrance to Boothbay Harbor, Pine Cliff, Lincoln County, ME

Hair shedding score may affect body temperature more than hair coat color during heat stress in weaned beef heifers.

USDA-ARS?s Scientific Manuscript database

The objective of this study was to evaluate the effect of hair shedding score and hair coat color on the vaginal temperature (VT) of calves during heat stress. Weaned Bos taurus beef heifers (n = 32; BW = 282 ± 6.4 kg) were assigned to a hair coat color class (BLACK; RED; or LIGHT, where LIGHT = yel...

Kinetic Modeling Sheds Light on the Mode of Action of Recombinant Factor VIIa on Thrombin Generation

DTIC Science & Technology

2011-01-01

Regular Article Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation Alexander Y. Mitrophanov...its effects on the quantitative parameters of thrombin generation. For recombinant activated factor VII (rFVIIa) ― a promising hemostasis-inducing...modulate thrombin production , it is necessary to identify rFVIIa-induced effects that are compatible with the available biochemical knowledge about

This pineal gland does not mediate phase shifts in the disc shedding rhythm of the rat retina

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldman, A.I.

Albino rats were subjected to pinealectomy, superior cervical ganglionectomy, or the appropriate sham preparation and were placed in lighting conditions so that light onset was advanced by 10 hr. After 6 days of this regimen, all animals exhibited a complete shift in their outer segment disc shedding rhythm, indicating that the pineal gland is not a factor in mediating such a shift.

Shedding More Light and Less Heat on the Results of School Integration. The Georgia Experience.

ERIC Educational Resources Information Center

Christison, Milton; Sida, Donald

One hundred and eighty-eight Georgia school system superintendents were polled in the Spring of 1976 as to their perceptions and experiences concerning the effects of school integration. This paper presents the results of this investigation. Three broad areas were selected for analysis: (1) integration outcomes affecting the public schools, (2)…

How To Survive in Postindustrial Environments: Adam Smith's Advice for Today's Colleges and Universities.

ERIC Educational Resources Information Center

Ortmann, Andreas

1997-01-01

Adam Smith's discussion of the payment modes of teachers and resulting consequences for the quality of teaching and process of curricular innovation are reviewed through the conceptual lens of modern agency theory. Smith's analysis of higher education in his day (eighteenth century) sheds light on faculty incentive and assessment problems that…

A Multivariate Genetic Analysis of Specific Phobia, Separation Anxiety and Social Phobia in Early Childhood

ERIC Educational Resources Information Center

Eley, Thalia C.; Rijsdijk, Fruhling V.; Perrin, Sean; O'Connor, Thomas G.; Bolton, Derek

2008-01-01

Background: Comorbidity amongst anxiety disorders is very common in children as in adults and leads to considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We…

A Feel for the Game--A Bourdieuian Analysis of Principal Leadership: A Study of Queensland Secondary School Principals

ERIC Educational Resources Information Center

Addison, Bruce

2009-01-01

Educational leadership discourse has for sometime been the major intellectual pillar of what was once known as the field of educational administration. An examination of the postgraduate coursework programmes available to aspiring principal leaders at every Australian university supports such a contention. While this discourse does shed light on…

Narrating the Visual: Accounting for and Projecting Actions in Webinar Q&As

ERIC Educational Resources Information Center

Yu, Di; Tadic, Nadja

2018-01-01

Visual conduct, including the use of gaze to attend to bodily-visual cues and other semiotic resources in interaction, has long been a topic of interest in ethnomethodology and conversation analysis (EMCA). Past EMCA work has examined visual conduct in face-to-face interaction, shedding light on the use of gaze to secure recipiency, facilitate…

Language Policies in Play: Learning Ecologies in Multilingual Preschool Interactions among Peers and Teachers

ERIC Educational Resources Information Center

Cekaite, Asta; Evaldsson, Ann-Carita

2017-01-01

In this study we argue that a focus on language learning ecologies, that is, situations for participation in various communicative practices, can shed light on the intricate processes through which minority children develop or are constrained from acquiring cultural and linguistic competencies (here, of a majority language). The analysis draws on…

A Typology of Knowledge Collaboration: A Case Study of an Initiative to Accelerate the Internationalization of Finnish Cleantech Entrepreneurship

ERIC Educational Resources Information Center

Vauterin, Johanna Julia; Virkki-Hatakka, Terhi

2016-01-01

A critical understanding of how knowledge collaboration may work in various configurations is a prerequisite in shedding light on how effective knowledge collaboration affects opportunities for business growth. This article presents a case analysis of a knowledge collaboration initiative between a university and other knowledge organizations. The…

Managing Victim Status in Group Therapy for Men: A Discourse Analysis

ERIC Educational Resources Information Center

Zverina, Michaela; Stam, Henderikus J.; Babins-Wagner, Robbie

2011-01-01

In contrast to the abundance of research on women victims, this article sheds light on the discourse of men who are self-identified as victims of their female partners' abuse. The purpose of this study was to investigate the most salient identity constructions and abuse conceptualizations among participants of group psychotherapy for men who have…

Pragmatic Assessment of Request Speech Act of Iranian EFL Learners by Non-Native English Speaking Teachers

ERIC Educational Resources Information Center

Alemi, Minoo; Khanlarzadeh, Neda

2016-01-01

The analysis of raters' comments on pragmatic assessment of L2 learners is among new and understudied concepts in second language studies. To shed light on this issue, the present investigation targeted important variables such as raters' criteria and rating patterns by analyzing the interlanguage pragmatic assessment process of the Iranian…

Trade-offs between light interception and leaf water shedding: a comparison of shade- and sun-adapted species in a subtropical rainforest.

PubMed

Meng, Fengqun; Cao, Rui; Yang, Dongmei; Niklas, Karl J; Sun, Shucun

2014-01-01

Species in high-rainfall regions have two major alternative approaches to quickly drain off water, i.e., increasing leaf inclination angles relative to the horizontal plane, or developing long leaf drip tips. We hypothesized that shade-adapted species will have more pronounced leaf drip tips but not greater inclination angles (which can reduce the ability to intercept light) compared to sun-adapted species and that length of leaf drip tips will be negatively correlated with photosynthetic capacity [characterized by light-saturated net photosynthetic rates (Amax), associated light compensation points (LCP), and light saturation points (LSP)]. We tested this hypothesis by measuring morphological and physiological traits that are associated with light-interception and water shedding for seven shade-adapted shrub species, ten sun-adapted understory shrub species, and 15 sun-adapted tree species in a subtropical Chinese rainforest, where mean annual precipitation is around 1,600 mm. Shade-adapted understory species had lower LMA, Amax, LSP, and LCP compared to understory or canopy sun-adapted species; their leaf and twig inclination angles were significantly smaller and leaf drip tips were significantly longer than those in sun-adapted species. This suggests that shade-adapted understory species tend to develop pronounced leaf drip tips but not large leaf inclination angles to shed water. The length of leaf drip tips was negatively correlated with leaf inclination angles and photosynthetic capacity. These relationships were consistent between ordinary regression and phylogenetic generalized least squares analyses. Our study illustrates the trade-offs between light interception and leaf water shedding and indicates that length of leaf drip tips can be used as an indicator of adaptation to shady conditions and overall photosynthetic performance of shrub species in subtropical rainforests.

Shedding Light on Thirteen Years of Darkness: Content Analysis of Articles Pertaining to Transgender Issues in Marriage/Couple and Family Therapy Journals

ERIC Educational Resources Information Center

Blumer, Markie L. C.; Green, Mary S.; Knowles, Sarah J.; Williams, April

2012-01-01

What is the extent to which marriage/couple and family therapy (M/CFT) journals address transgender issues and how many of them say they are inclusive of transgender persons when they are not? To answer these queries, a content analysis was conducted on articles published in M/CFT literature from 1997 through 2009. Of the 10,739 articles examined…

Critical Discourse Analysis of Discursive Reproduction of Identities in the Thai Undergraduates' Home for Children with Disabilities Website Project: Critical Analysis of Lexical Selection

ERIC Educational Resources Information Center

Sudajit-apa, Melada

2017-01-01

Analyzing discourses can shed light on language as a social semiotic system, the construction of identity and the operations of ideology and power. The purpose of this study is twofold. Firstly, it aims to unveil Thai fourth-year English-major students' utilization of lexical choices with connotations that enact the identities of the Baan Nontapum…

Exploratory flow visualization investigation of mast-mounted sights in presence of a rotor

NASA Technical Reports Server (NTRS)

Ghee, Terence A.; Kelley, Henry L.

1995-01-01

A flow visualization investigation with a laser light sheet system was conducted on a 27-percent-scale AH-64 attack helicopter model fitted with two mast-mounted sights in the langley 14- by 22-foot subsonic tunnel. The investigation was conducted to identify aerodynamic phenomena that may have contributed to adverse vibration encountered during full-scale flight of the AH-64D apache/longbow helicopter with an asymmetric mast-mounted sight. Symmetric and asymmetric mast-mounted sights oriented at several skew angles were tested at simulated forward and rearward flight speeds of 30 and 45 knots. A laser light sheet system was used to visualize the flow in planes parallel to and perpendicular to the free-stream flow. Analysis of these flow visualization data identified frequencies of flow patterns in the wake shed from the sight, the streamline angle at the sight, and the location where the shed wake crossed the rotor plane. Differences in wake structure were observed between the sight configurations and various skew angles. Analysis of lateral light sheet plane data implied significant vortex structure in the wake of the asymmetric mast-mounted sight in the configuration that produced maximum in-flight vibration. The data showed no significant vortex structure in the wake of the asymmetric and symmetric configurations that produced no increase in in-flight adverse vibration.

''I Don't Want to Become a China Buff'': Temporal Dimensions of the Discoursal Construction of Writer Identity

ERIC Educational Resources Information Center

Burgess, Amy

2012-01-01

This paper offers detailed analysis of ethnographic data concerning an adult literacy student producing and discussing a text about China, using the framework for investigating the discoursal construction of writer identity developed by Burgess and Ivanic (2010). It sheds light on how writer identity changes and develops over time by showing how…

Interrogating an Omission: The Absence of a Rights-Based Approach to Education in World Bank Policy Discourse

ERIC Educational Resources Information Center

Menashy, Francine

2013-01-01

This study provides a discursive analysis of World Bank policy documents in order to reveal the stark omission of a rights-based approach to education, while highlighting instead the support of an economic-instrumentalist approach. Plausible explanations are provided to shed light on this exclusion, including the feasibility critique of education…

The Image of Today's Russian Armed Forces in the Eyes of Young People

ERIC Educational Resources Information Center

Novik, V. K.; Perednia, D. G.

2008-01-01

In the recent past there has been animated discussion of problems related to the image of the various social institutions and state organizations of Russia, including the Russian armed forces. Sociological analysis is a constructive way to shed light on the image of the military. The armed forces are linked closely to the main spheres of the life…

Case Method Teaching as Science and Art: A Metaphoric Approach and Curricular Application

ERIC Educational Resources Information Center

Greenhalgh, Anne M.

2007-01-01

The following article takes a metaphoric approach to case method teaching to shed light on one of our most important practices. The article hinges on the dual comparison of case method as science and as art. The dominant, scientific view of cases is that they are neutral descriptions of real-life business problems, subject to rigorous analysis.…

The Process of Integration of Newcomers at School: Students and Gender Networking during School Recess

ERIC Educational Resources Information Center

Rodriguez-Navarro, Henar; García-Monge, Alfonso; Rubio-Campos, Maria del Carmen

2014-01-01

This article examines the data obtained through a year-long ethnographic study of students from a Spanish primary school, and sheds light on their use of gender code networks during school recess. The results of this analysis confirm the conclusions on student interaction drawn by other studies (group segregation regarding age and gender and,…

The Contribution of HBCUS to the Preparation of African American Women for STEM Careers: A Case Study

ERIC Educational Resources Information Center

Perna, Laura; Lundy-Wagner, Valerie; Drezner, Noah D.; Gasman, Marybeth; Yoon, Susan; Bose, Enakshi; Gary, Shannon

2009-01-01

This study uses case study analysis to explore the ways that Spelman College, a historically Black women's college, promotes the attainment of African American women in STEM fields. Although limited to one institution, the findings shed light on the ways that institutional characteristics, policies, and practices may mitigate the barriers that…

Where We're Going--What We Know about the World Past Y2K.

ERIC Educational Resources Information Center

Levin, Bernard H.

An analysis of economic, social, and demographic trends can shed light on how two-year colleges and other social institutions will be affected in the future. According to census data, the percentage of children living with one parent increased from 12% in 1974 to 27% in 1994, while the percentage of households without married couples is projected…

Differential Distractor Functioning as a Method for Explaining DIF: The Case of a National Admissions Test in Saudi Arabia

ERIC Educational Resources Information Center

Tsaousis, Ioannis; Sideridis, Georgios; Al-Saawi, Fahad

2018-01-01

The aim of the present study was to examine Differential Distractor Functioning (DDF) as a means of improving the quality of a measure through understanding biased responses across groups. A DDF analysis could shed light on the potential sources of construct-irrelevant variance by examining whether the differential selection of incorrect choices…

Genome Sequence Analysis of the Biogenic Amine-Degrading Strain Lactobacillus casei 5b

PubMed Central

Ladero, Victor; Herrero-Fresno, Ana; Martinez, Noelia; del Río, Beatriz; Linares, Daniel M.; Fernández, María; Martín, María Cruz

2014-01-01

We here report a 3.02-Mbp annotated draft assembly of the Lactobacillus casei 5b genome. The sequence of this biogenic amine-degrading dairy isolate may help identify the mechanisms involved in the catabolism of biogenic amines and perhaps shed light on ways to reduce the presence of these toxic compounds in food. PMID:24435875

The Sense of Self: Topics in the Semantics of De Se Expressions

ERIC Educational Resources Information Center

Pearson, Hazel Anne

2012-01-01

This work investigates a series of phenomena that shed light on the analysis of attitudes de se. We adopt Lewis' (1979) proposal that attitudes de se involve self-ascription of a property, and investigate how this view of mental content is reflected in natural language. The implementation favored is a strong version of Lewis' position:…

The process of deforestation in weak democracies and the role of Intelligence.

PubMed

Obydenkova, Anastassia; Nazarov, Zafar; Salahodjaev, Raufhon

2016-07-01

This article examines the interconnection between national intelligence, political institutions, and the mismanagement of public resources (deforestations). The paper examines the reasons for deforestation and investigates the factors accountable for it. The analysis builds on authors-compiled cross-national dataset on 185 countries over the time period of twenty years, from 1990 to 2010. We find that, first, nation's intelligence reduces significantly the level of deforestation in a state. Moreover, the nations' IQ seems to play an offsetting role in the natural resource conservation (forest management) in the countries with weak democratic institutions. The analysis also discovered the presence of the U-shaped relationship between democracy and deforestation. Intelligence sheds more light on this interconnection and explains the results. Our results are robust to various sample selection strategies and model specifications. The main implication from our study is that intelligence not only shapes formal rules and informal regulations such as social trust, norms and traditions but also it has the ability to reverse the paradoxical process known as "resource curse." The study contributes to better understanding of reasons of deforestation and shed light on the debated impact of political regime on forest management. Copyright © 2016 Elsevier Inc. All rights reserved.

Microphysics of liquid complex plasmas in equilibrium and non-equilibrium systems

NASA Astrophysics Data System (ADS)

Piel, Alexander; Block, Dietmar; Melzer, André; Mulsow, Matthias; Schablinski, Jan; Schella, André; Wieben, Frank; Wilms, Jochen

2018-05-01

The dynamic evolution of the microscopic structure of solid and liquid phases of complex plasmas is studied experimentally and by means of molecular dynamics (MD) simulations. In small finite systems, the cooperative motion can be described in terms of discrete modes. These modes are studied with different experimental approaches. Using diffuse scattered laser light, applying laser tweezer forces to individual particles, and periodic laser pulses, the excitation of modes is investigated. The instantaneous normal mode analysis of experimental data from two-dimensional liquid clusters gives access to the local dynamics of the liquid phase. Our investigations shed light on the role of compressional and shear modes as well as the determination of diffusion constants and melting temperatures in finite systems. Special attention is paid to hydrodynamic situations with a stationary inhomogeneous dust flow. MD simulations allow to study the collective motion in the shell of nearest neighbors, which can be linked to smooth and sudden changes of the macroscopic flow. Finally, the observed micro-motion in all situations above allows to shed light on the preference of shear-like over compressional motion in terms of a minimized potential energy and a dynamic incompressibility.

Analysis of experts' perception of the effectiveness of teaching methods

NASA Astrophysics Data System (ADS)

Kindra, Gurprit S.

1984-03-01

The present study attempts to shed light on the perceptions of business educators regarding the effectiveness of six methodologies in achieving Gagné's five learning outcomes. Results of this study empirically confirm the oft-stated contention that no one method is globally effective for the attainment of all objectives. Specifically, business games, traditional lecture, and case study methods are perceived to be most effective for the learning of application, knowledge acquisition, and analysis and application, respectively.

7. Outhouse and shed, view west northwest, south and east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Outhouse and shed, view west northwest, south and east sides - Ram Island Light Station, Ram Island, south of Ocean Point & just north of Fisherman Island, marking south side of Fisherman Island Passage, Ocean Point, Lincoln County, ME

7. Shed and keeper' house with helicopter pad in foreground, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Shed and keeper' house with helicopter pad in foreground, view east, southwest and northwest sides - Goat Island Light Station, Goat Island, next to entrance to Cape Porpoise Harbor, just south of Trott Island, Cape Porpoise, York County, ME

Shedding Light on Learning.

ERIC Educational Resources Information Center

Graves, Ben E.

1985-01-01

Summarizes findings of an Alberta light/color study that looked at mood, noise levels, IQ test scores, blood pressure, and absences under fluorescent or full-spectrum light in two color schemes in four elementary schools with 700 students. (MLF)

PHAROS: Shedding Light on the Near-Earth Asteroid Apophis

NASA Technical Reports Server (NTRS)

Sharma, Jonathan; Lafleur, Jarret; Barron, Kreston; Townley, Jonathan; Shah, Nilesh; Apa, Jillian

2007-01-01

The Pharos mission to asteroid Apophis provides the first major opportunity to enhance orbital state and scientific knowledge of the most threatening Earth-crossing asteroid that has ever been tracked. Pharos aims to accomplish concrete and feasible orbit determination and scientific objectives while achieving balance among mission cost, nsk,and schedule. Similar to its ancient Egyptian namesake, Pharos acts as a beacon shedding light not only on the physical characteristics of Apophis, but also on its state as it travels through the solar system.

Shedding Some Light.

ERIC Educational Resources Information Center

Whitney, Tim

1998-01-01

Discusses the basics of designing natural and artificial light in an indoor athletic facility. Also examines individual lighting requirements of typical rooms such as weight and fitness rooms, aerobics and multipurpose rooms, gymnasiums, field houses, pools, and racquetball and squash courts. (GR)

Conditional Belief Types

DTIC Science & Technology

2016-04-19

event is the same as conditioning on the event being certain, which formalizes the standard informal interpretation of conditional probability. The game ...theoretic application of our model, discussed within an example, sheds light on a number of issues in the analysis of extensive form games . Type...belief types Block 13: Supplementary Note © 2014 . Published in Games and Economic Behavior, Vol. Ed. 0 87, (0) (2014), (, (0). DoD Components

Novices "In Story": What First-Year Teachers' Narratives Reveal about the Shady Corners of Teaching

ERIC Educational Resources Information Center

Orland-Barak, Lily; Maskit, Ditza

2011-01-01

In a national contest of story writing in Israel, first-year teachers from all educational sectors were invited to write a story that mirrors their first year of teaching experience. The narrative analysis of the stories sheds light on the hostile and adverse sides of teaching, surfacing novices' sense of impotence in their capacity to act. The…

Security Vulnerability and Patch Management in Electric Utilities: A Data-Driven Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Qinghua; Zhang, Fengli

This paper explores a real security vulnerability and patch management dataset from an electric utility in order to shed light on characteristics of the vulnerabilities that electric utility assets have and how they are remediated in practice. Specifically, it first analyzes the distribution of vulnerabilities over software, assets, and other metric. Then it analyzes how vulnerability features affect remediate actions.

Voices and Perspectives in Norwegian Pupils' Work on Religions and World Views: A Diachronic Study Applying Sociocultural Learning Theory

ERIC Educational Resources Information Center

Haakedal, Elisabet

2012-01-01

This article researches work by four pupils in a diachronic collection of Norwegian primary school workbooks. Given signs of a variety of voices and perspectives in chosen representations of central tenets and/or practices in religions and philosophical traditions, how can an analysis and discussion of a few chosen texts shed light on their…

The Analysis of Kutadgu Bilig in Terms of Values Education

ERIC Educational Resources Information Center

Tural, Aysegul

2018-01-01

Kutadgu Bilig is one of the literal works that shed light on Turk-Islam history and culture. In this study, it is aimed to examine Kutagu Bilig in terms of values that are involved in social studies teaching program. In research, Kutadgu Bilig work that is written by Yusuf Has Hacip and is adopted to Turkish in today by Silahdaroglu is benefitted…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hovel, Harold; Prettyman, Kevin

A side-by-side analysis was done on then currently available technology, along with roadmaps to push each particular option forward. Variations in turnkey line processes can and do result in finished solar device performance. Together with variations in starting material quality, the result is a distribution of effciencies. Forensic analysis and characterization of each crystalline Si based technology will determine the most promising approach with respect to cost, efficiency and reliability. Forensic analysis will also shed light on the causes of binning variations. Si solar cells were forensically analyzed from each turn key supplier using a host of techniques

The phenomenon of dynamic stall. [vortex shedding phenomenon on oscillating airfoils

NASA Technical Reports Server (NTRS)

Mccroskey, W. J.

1981-01-01

The general features of dynamic stall on oscillating airfoils are explained in terms of the vortex shedding phenomenon, and the important differences between static stall, light dynamic stall, and deep stall are described. An overview of experimentation and prediction techniques is given.

A new light on caloric test--what was disclosed by three dimensional analysis of caloric nystagmus?

NASA Technical Reports Server (NTRS)

Arai, Y.

2001-01-01

For better understanding of caloric nystagmus, this phenomenon will be reviewed historically in three stages. 1) The first light on caloric nystagmus was thrown by Barany 1906. Through direct observation of eye movements, Barany established the caloric test as an important tool to determine the side of lesion for vertigo. 2) The second light is shed by electrooculogram (EOG) from the late 1950th. EOG enabled qualitative analysis of caloric nystagmus, and proved Barany's convection theory, but resulted in neglect of vertical and roll eye movements. 3) The third light is gained by 3D recording of eye movements started from the late 1980th. 3D recordings of eye movements enabled us to analyze the spatial orientation of caloric nystagmus, and disclose the close correlation of the nystagmus components in the head vertical and the space vertical planes, suggesting a contribution of the velocity storage integrator. The 3D property of caloric nystagmus will be explained in detail.

The Role of Credit Constraints in Educational Choices: Evidence from NCDS and BCS70. CEE DP 48

ERIC Educational Resources Information Center

Dearden, Lorraine; McGranahan, Leslie; Sianesi, Barbara

2004-01-01

In this analysis we seek to shed light on the extent to which credit constraints may affect individuals' choices to stay in full-time education past the age of 16 and to complete higher education (HE) qualifications in the United Kingdom, and on how this has varied between individuals born in 1958 and in 1970. The observed correlation between…

Language for Reconciliation in Religious Discourse: A Critical Discourse Analysis of Contradictions in Sermons Explored through the Activity Theory Framework

ERIC Educational Resources Information Center

Singh, Parvinder Kaur Hukam; Thuraisingam, Thavamalar

2011-01-01

This paper attempts to shed light on the role of language in keeping religion relevant to the individual and society in present times. In the context of postmodernity, religion has become more of a meaning system to address the existential questions of the individual. Religious institutions have had to accommodate the changes brought about by a…

Intercultural Learning in English as Foreign Language Instruction: The Importance of Teachers' Intercultural Experience and the Usefulness of Precise Instructional Directives

ERIC Educational Resources Information Center

Gobel, Kerstin; Helmke, Andreas

2010-01-01

The development of intercultural competence, especially in foreign language instruction, is considered a key goal of teaching in German schools. The present article sheds light on the teaching of intercultural topics in the context of English as a foreign language (EFL). It presents the results of an analysis of data from a larger study (DESI…

Molecular Genetic Analysis of Phototropism in Arabidopsis

PubMed Central

Sakai, Tatsuya; Haga, Ken

2012-01-01

Plant life is strongly dependent on the environment, and plants regulate their growth and development in response to many different environmental stimuli. One of the regulatory mechanisms involved in these responses is phototropism, which allows plants to change their growth direction in response to the location of the light source. Since the study of phototropism by Darwin, many physiological studies of this phenomenon have been published. Recently, molecular genetic analyses of Arabidopsis have begun to shed light on the molecular mechanisms underlying this response system, including phototropin blue light photoreceptors, phototropin signaling components, auxin transporters, auxin action mechanisms and others. This review highlights some of the recent progress that has been made in further elucidating the phototropic response, with particular emphasis on mutant phenotypes. PMID:22864452

Molecular genetic analysis of phototropism in Arabidopsis.

PubMed

Sakai, Tatsuya; Haga, Ken

2012-09-01

Plant life is strongly dependent on the environment, and plants regulate their growth and development in response to many different environmental stimuli. One of the regulatory mechanisms involved in these responses is phototropism, which allows plants to change their growth direction in response to the location of the light source. Since the study of phototropism by Darwin, many physiological studies of this phenomenon have been published. Recently, molecular genetic analyses of Arabidopsis have begun to shed light on the molecular mechanisms underlying this response system, including phototropin blue light photoreceptors, phototropin signaling components, auxin transporters, auxin action mechanisms and others. This review highlights some of the recent progress that has been made in further elucidating the phototropic response, with particular emphasis on mutant phenotypes.

Investigation on bandgap, diffraction, interference, and refraction effects of photonic crystal structure in GaN/InGaN LEDs for light extraction.

PubMed

Patra, Saroj Kanta; Adhikari, Sonachand; Pal, Suchandan

2014-06-20

In this paper, we have made a clear differentiation among bandgap, diffraction, interference, and refraction effects in photonic crystal structures (PhCs). For observing bandgap, diffraction, and refraction effects, PhCs are considered on the top p-GaN surface of light emitting diodes (LEDs), whereas for interference effect, hole type PhCs are considered to be embedded within n-GaN layer of LED. From analysis, it is observed that at a particular lattice periodicity, for which bandgap lies within the wavelength of interest shows a significant light extraction due to inhibition of guided mode. Beyond a certain periodicity, diffraction effect starts dominating and light extraction improves further. The interference effect is observed in embedded photonic crystal LEDs, where depth of etching supports constructive interference of outward light waves. We have also shed light on refraction effects exhibited by the PhCs and whether negative refraction properties of PhCs may be useful in case of LED light extraction.

Benchmarks of Global Clean Energy Manufacturing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sandor, Debra; Chung, Donald; Keyser, David

The Clean Energy Manufacturing Analysis Center (CEMAC), sponsored by the U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE), provides objective analysis and up-to-date data on global supply chains and manufacturing of clean energy technologies. Benchmarks of Global Clean Energy Manufacturing sheds light on several fundamental questions about the global clean technology manufacturing enterprise: How does clean energy technology manufacturing impact national economies? What are the economic opportunities across the manufacturing supply chain? What are the global dynamics of clean energy technology manufacturing?

Classification of Phase Transitions by Microcanonical Inflection-Point Analysis

NASA Astrophysics Data System (ADS)

Qi, Kai; Bachmann, Michael

2018-05-01

By means of the principle of minimal sensitivity we generalize the microcanonical inflection-point analysis method by probing derivatives of the microcanonical entropy for signals of transitions in complex systems. A strategy of systematically identifying and locating independent and dependent phase transitions of any order is proposed. The power of the generalized method is demonstrated in applications to the ferromagnetic Ising model and a coarse-grained model for polymer adsorption onto a substrate. The results shed new light on the intrinsic phase structure of systems with cooperative behavior.

Amplitude analysis and the nature of the Z c(3900)

DOE PAGES

Pilloni, A.; Fernandez-Ramirez, C.; Jackura, A.; ...

2017-06-21

The microscopic nature of the XYZ states remains an unsettled topic. We show how a thorough amplitude analysis of the data can help constraining models of these states. Specifically, we consider the case of the Z c(3900) peak and discuss possible scenarios of a QCD state, virtual state, or a kinematical enhancement. Here, we conclude that current data are not precise enough to distinguish between these hypotheses, however, the method we propose, when applied to the forthcoming high-statistics measurements should shed light on the nature of these exotic enhancements.

Amplitude analysis and the nature of the Z c(3900)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pilloni, A.; Fernandez-Ramirez, C.; Jackura, A.

The microscopic nature of the XYZ states remains an unsettled topic. We show how a thorough amplitude analysis of the data can help constraining models of these states. Specifically, we consider the case of the Z c(3900) peak and discuss possible scenarios of a QCD state, virtual state, or a kinematical enhancement. Here, we conclude that current data are not precise enough to distinguish between these hypotheses, however, the method we propose, when applied to the forthcoming high-statistics measurements should shed light on the nature of these exotic enhancements.

Children's Rights and Educational Policy in Europe: The Implementation of the United Nations Convention on the Rights of the Child

ERIC Educational Resources Information Center

Lundy, Laura

2012-01-01

This article aims to shed light on the impact of the United Nations Convention on the Rights of the Child (CRC) on education policy in Europe. The findings are based on a documentary analysis of the published reports of the Committee on the Rights of the Child (the Committee) on the implementation of the education rights in the CRC in every EU…

The interaction of light and gravity on the transmission of Echinostoma caproni (Digenea: Echinostomatidae) cercariae to the second intermediate host, Biomphalaria glabrata (Gastropoda: Pulmonata).

PubMed

Platt, Thomas R; Greenlee, Hali; Zelmer, Derek A

2010-04-01

The current experiments were designed to assess the interaction of light and gravity on the transmission of Echinostoma caproni cercariae to the second intermediate host, Biomphalaria glabrata. Transmission chambers were constructed of clear polyvinyl chloride pipe covered with a black sleeve to exclude light. Snails were constrained within the chamber to prevent movement, while permitting the cercariae to swim freely. A trial consisted of 2 infected B. glabrata shedding E. caproni cercariae placed at the center of the chamber with 5 uninfected B. glabrata placed 10 cm above and below the shedding snails as sentinels. Three experiments, consisting of 12 trials each, were conducted under the following lighting conditions, i.e., above and below the transmission chamber, and in complete darkness. In all 3 experiments, the proportion of metacercariae was significantly higher in snails at the top of the chamber. The results suggest that a negative geotaxis is the primary factor in the initial dispersal of E. caproni cercariae. Coupling negative geotaxis and positive phototaxis (light from above) resulted in a significantly higher proportion of metacercariae in sentinel snails at the top of the transmission chamber when corrected for cercarial density. There was no significant difference in the proportion of metacercariae in snails at the top or bottom of the transmission chamber with light at the bottom of the chamber or in complete darkness. Cercariae of E. caproni only respond to light in context, i.e., from above, and ignore the light stimulus when it comes from an unexpected location (bottom of the water column). Significantly greater numbers of cercariae were released from shedding snails when light was present, suggesting that emergence of cercariae from B. glabrata is dependent on light regardless of the position of the light source.

SHEDDING LIGHT ON CORALS HEALTH: INTERACTIONS OF CLIMATE CHANGE AND SOLAR RADIATION WITH BLEACHING

EPA Science Inventory

Coral bleaching and declines in coral reef health in recent years have been attributed in part to processes driven by UV and/or visible light. For coral assemblages, exposure to UV light is often an unavoidable consequence of having access to visible (photosynthetically active) ...

33 CFR 165.810 - Mississippi River, LA-regulated navigation area.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (c) Movement of vessels in vicinity of Algiers Point, New Orleans Harbor: (1) Control lights. When... green lights designated and located as follows: Governor Nicholls Light located on the left descending bank on the wharf shed at the upstream end of Esplanade Avenue Wharf, New Orleans, approximately 94.3...

Shedding Some Light on Fluorescent Bulbs.

ERIC Educational Resources Information Center

Guilbert, Nicholas R.

1996-01-01

Explores some of the principles behind the working of fluorescent bulbs using a specially prepared fluorescent bulb with the white inner fluorescent coating applied along only half its length. Discusses the spectrum, the bulb plasma, and light production. (JRH)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hosseinizadeh, Ahmad; Mashayekhi, Ghoncheh; Copperman, Jeremy

Using a manifold-based analysis of experimental diffraction snapshots from an X-ray free electron laser, we determine the three-dimensional structure and conformational landscape of the PR772 virus to a detector-limited resolution of 9 nm. Our results indicate that a single conformational coordinate controls reorganization of the genome, growth of a tubular structure from a portal vertex and release of the genome. Furthermore, these results demonstrate that single-particle X-ray scattering has the potential to shed light on key biological processes.

Spectrum Project

NASA Image and Video Library

2017-10-16

Inside the Spectrum prototype unit, organisms in a Petri plate are exposed to blue excitation lighting. The device works by exposing organisms to different colors of fluorescent light while a camera records what's happening with time-lapse photography. Results from the Spectrum project will shed light on which living things are best suited for long-duration flights into deep space.

Spectrum Project

NASA Image and Video Library

2017-10-16

Inside the Spectrum prototype unit, organisms in a Petri plate are exposed to different colors of lighting. The device works by exposing organisms to different colors of fluorescent light while a camera records what's happening with time-lapse photography. Results from the Spectrum project will shed light on which living things are best suited for long-duration flights into deep space.

Analysis and Prediction of Ice Shedding for a Full-Scale Heated Tail Rotor

NASA Technical Reports Server (NTRS)

Kreeger, Richard E.; Work, Andrew; Douglass, Rebekah; Gazella, Matthew; Koster, Zakery; Turk, Jodi

2016-01-01

When helicopters are to fly in icing conditions, it is necessary to consider the possibility of ice shed from the rotor blades. In 2013, a series of tests were conducted on a heated tail rotor at NASA Glenn's Icing Research Tunnel (IRT). The tests produced several shed events that were captured on camera. Three of these shed events were captured at a sufficiently high frame rate to obtain multiple images of the shed ice in flight that had a sufficiently long section of shed ice for analysis. Analysis of these shed events is presented and compared to an analytical Shedding Trajectory Model (STM). The STM is developed and assumes that the ice breaks off instantly as it reaches the end of the blade, while frictional and viscous forces are used as parameters to fit the STM. The trajectory of each shed is compared to that predicted by the STM, where the STM provides information of the shed group of ice as a whole. The limitations of the model's underlying assumptions are discussed in comparison to experimental shed events.

Stimulus Control: The Sought or Unsought Influence of the Objects We Tend to

ERIC Educational Resources Information Center

Morsella, Ezequiel; Larson, Lindsay R. L.; Zarolia, Pareezad; Bargh, John A.

2011-01-01

Does the mere presence of the things we have tended to influence our actions systematically, in ways that escape our awareness? For example, while entering a tool shed, does perceiving objects that we once tended to (e.g., tools, musical instruments) influence how we then execute a simple action (e.g., flicking the shed's light switch)? Ancient…

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.

PubMed

Schmidts, Miriam; Hou, Yuqing; Cortés, Claudio R; Mans, Dorus A; Huber, Celine; Boldt, Karsten; Patel, Mitali; van Reeuwijk, Jeroen; Plaza, Jean-Marc; van Beersum, Sylvia E C; Yap, Zhi Min; Letteboer, Stef J F; Taylor, S Paige; Herridge, Warren; Johnson, Colin A; Scambler, Peter J; Ueffing, Marius; Kayserili, Hulya; Krakow, Deborah; King, Stephen M; Beales, Philip L; Al-Gazali, Lihadh; Wicking, Carol; Cormier-Daire, Valerie; Roepman, Ronald; Mitchison, Hannah M; Witman, George B

2015-06-05

The analysis of individuals with ciliary chondrodysplasias can shed light on sensitive mechanisms controlling ciliogenesis and cell signalling that are essential to embryonic development and survival. Here we identify TCTEX1D2 mutations causing Jeune asphyxiating thoracic dystrophy with partially penetrant inheritance. Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist Chlamydomonas, accompanied by destabilization of the retrograde IFT dynein motor. We thus define TCTEX1D2 as an integral component of the evolutionarily conserved retrograde IFT machinery. In complex with several IFT dynein light chains, it is required for correct vertebrate skeletal formation but may be functionally redundant under certain conditions.

UVC Sheds New Light on School Mold Problems.

ERIC Educational Resources Information Center

Freeman, James

2002-01-01

Describes how the LaPorte Independent School District in Texas turned to ultraviolent light devices installed within the HVAC system to combat mold and fungus after conventional approaches failed. Describes the additional benefits of energy savings from the system. (EV)

Shedding new light on opsin evolution

PubMed Central

Porter, Megan L.; Blasic, Joseph R.; Bok, Michael J.; Cameron, Evan G.; Pringle, Thomas; Cronin, Thomas W.; Robinson, Phyllis R.

2012-01-01

Opsin proteins are essential molecules in mediating the ability of animals to detect and use light for diverse biological functions. Therefore, understanding the evolutionary history of opsins is key to understanding the evolution of light detection and photoreception in animals. As genomic data have appeared and rapidly expanded in quantity, it has become possible to analyse opsins that functionally and histologically are less well characterized, and thus to examine opsin evolution strictly from a genetic perspective. We have incorporated these new data into a large-scale, genome-based analysis of opsin evolution. We use an extensive phylogeny of currently known opsin sequence diversity as a foundation for examining the evolutionary distributions of key functional features within the opsin clade. This new analysis illustrates the lability of opsin protein-expression patterns, site-specific functionality (i.e. counterion position) and G-protein binding interactions. Further, it demonstrates the limitations of current model organisms, and highlights the need for further characterization of many of the opsin sequence groups with unknown function. PMID:22012981

Surface roughness: A review of its measurement at micro-/nano-scale

NASA Astrophysics Data System (ADS)

Gong, Yuxuan; Xu, Jian; Buchanan, Relva C.

2018-01-01

The measurement of surface roughness at micro-/nano-scale is of great importance to metrological, manufacturing, engineering, and scientific applications given the critical roles of roughness in physical and chemical phenomena. The surface roughness of materials can significantly change the way of how they interact with light, phonons, molecules, and so forth, thus surface roughness ultimately determines the functionality and property of materials. In this short review, the techniques of measuring micro-/nano-scale surface roughness are discussed with special focus on the limitations and capabilities of each technique. In addition, the calculations of surface roughness and their theoretical background are discussed to offer readers a better understanding of the importance of post-measurement analysis. Recent progress on fractal analysis of surface roughness is discussed to shed light on the future efforts in surface roughness measurement.

Shear driven droplet shedding and coalescence on a superhydrophobic surface

NASA Astrophysics Data System (ADS)

Moghtadernejad, S.; Tembely, M.; Jadidi, M.; Esmail, N.; Dolatabadi, A.

2015-03-01

The interest on shedding and coalescence of sessile droplets arises from the importance of these phenomena in various scientific problems and industrial applications such as ice formation on wind turbine blades, power lines, nacelles, and aircraft wings. It is shown recently that one of the ways to reduce the probability of ice accretion on industrial components is using superhydrophobic coatings due to their low adhesion to water droplets. In this study, a combined experimental and numerical approach is used to investigate droplet shedding and coalescence phenomena under the influence of air shear flow on a superhydrophobic surface. Droplets with a size of 2 mm are subjected to various air speeds ranging from 5 to 90 m/s. A numerical simulation based on the Volume of Fluid method coupled with the Large Eddy Simulation turbulent model is carried out in conjunction with the validating experiments to shed more light on the coalescence of droplets and detachment phenomena through a detailed analysis of the aerodynamics forces and velocity vectors on the droplet and the streamlines around it. The results indicate a contrast in the mechanism of two-droplet coalescence and subsequent detachment with those related to the case of a single droplet shedding. At lower speeds, the two droplets coalesce by attracting each other with successive rebounds of the merged droplet on the substrate, while at higher speeds, the detachment occurs almost instantly after coalescence, with a detachment time decreasing exponentially with the air speed. It is shown that coalescence phenomenon assists droplet detachment from the superhydrophobic substrate at lower air speeds.

Alberi Validates New Theory, Sheds Light on Semiconductors | News | NREL

Science.gov Websites

the discovery when they found that light can suppress native defect formation during semiconductor growth. When Alberi and Scarpulla began discussing the concept of how light can affect semiconductor that pieces easily fit together, so are the atoms in the crystal. But when an atom appears in a crystal

Reaction Electronic Flux Perspective on the Mechanism of the Zimmerman Di-π-methane Rearrangement.

PubMed

Matute, Ricardo A; Pérez, Patricia; Chamorro, Eduardo; Villegas-Escobar, Nery; Cortés-Arriagada, Diego; Herrera, Barbara; Gutiérrez-Oliva, Soledad; Toro-Labbé, Alejandro

2018-06-01

The reaction electronic flux (REF) offers a powerful tool in the analysis of reaction mechanisms. Noteworthy, the relationship between aromaticity and REF can eventually reveal subtle electronic events associated with reactivity in aromatic systems. In this work, this relationship was studied for the triplet Zimmerman di-π-methane rearrangement. The aromaticity loss and gain taking place during the reaction is well acquainted by the REF, thus shedding light on the electronic nature of reactions involving dibenzobarrelenes.

Aircraft Modifications: Assessing the Current State of Air Force Aircraft Modifications and the Implications for Future Military Capability

DTIC Science & Technology

2007-01-25

Air, Space , and Cyberspace." Introduction 3 group production lots together into ’spirals’ or ’increments’. These groupings, as well as an increased...important reference point for this work. The analysis of the modification process presented in this reserach , however, does help shed light on the...planning efforts. Chapter 7- The Future of Aircraft Modifications "Strategy is the art of making use of time and space . I am less concerned about the

The Origins of Ethnolinguistic Diversity

PubMed Central

Michalopoulos, Stelios

2013-01-01

This study explores the determinants of ethnolinguistic diversity within as well as across countries shedding light on its geographic origins. The empirical analysis conducted across countries, virtual countries and pairs of contiguous regions establishes that geographic variability, captured by variation in regional land quality and elevation, is a fundamental determinant of contemporary linguistic diversity. The findings are consistent with the proposed hypothesis that differences in land endowments gave rise to location-specific human capital, leading to the formation of localized ethnicities. PMID:25258434

Connecting the Kuramoto Model and the Chimera State

NASA Astrophysics Data System (ADS)

Kotwal, Tejas; Jiang, Xin; Abrams, Daniel M.

2017-12-01

Since its discovery in 2002, the chimera state has frequently been described as a counterintuitive, puzzling phenomenon. The Kuramoto model, in contrast, has become a celebrated paradigm useful for understanding a range of phenomena related to phase transitions, synchronization, and network effects. Here we show that the chimera state can be understood as emerging naturally through a symmetry-breaking bifurcation from the Kuramoto model's partially synchronized state. Our analysis sheds light on recent observations of chimera states in laser arrays, chemical oscillators, and mechanical pendula.

Bringing diffuse X-ray scattering into focus

DOE PAGES

Wall, Michael E.; Wolff, Alexander M.; Fraser, James S.

2018-02-16

X-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure variations. Diffuse scattering is present in all macromolecular crystallography experiments. Recent studies are shedding light on the origins of diffuse scattering in protein crystallography, and provide clues for leveraging diffuse scattering to model protein motions with atomic detail.

Bringing diffuse X-ray scattering into focus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wall, Michael E.; Wolff, Alexander M.; Fraser, James S.

X-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure variations. Diffuse scattering is present in all macromolecular crystallography experiments. Recent studies are shedding light on the origins of diffuse scattering in protein crystallography, and provide clues for leveraging diffuse scattering to model protein motions with atomic detail.

Ray-optical theory of broadband partially coherent emission

NASA Astrophysics Data System (ADS)

Epstein, Ariel; Tessler, Nir; Einziger, Pinchas D.

2013-04-01

We present a rigorous formulation of the effects of spectral broadening on emission of partially coherent source ensembles embedded in multilayered formations with arbitrarily shaped interfaces, provided geometrical optics is valid. The resulting ray-optical theory, applicable to a variety of optical systems from terahertz lenses to photovoltaic cells, quantifies the fundamental interplay between bandwidth and layer dimensions, and sheds light on common practices in optical analysis of statistical fields, e.g., disregarding multiple reflections or neglecting interference cross terms.

Shedding Light on Engineering Design

ERIC Educational Resources Information Center

Capobianco, Brenda M.; Nyquist, Chell; Tyrie, Nancy

2013-01-01

This article describes the steps incorporated to teach an engineering design process in a fifth-grade science classroom. The engineering design-based activity was an existing scientific inquiry activity using UV light--detecting beads and purposefully creating a series of engineering design-based challenges around the investigation. The…

Shedding Light on Fiber Optics.

ERIC Educational Resources Information Center

Bunch, Robert M.

1994-01-01

Explains the principles of fiber optics as a medium for light-wave communication. Current uses of fiber systems on college campuses include voice, video, and local area network applications. A group of seven school districts in Minnesota are linked via fiber-optic cables. Other uses are discussed. (MLF)

Polyphasic analysis of an Azoarcus-Leptothrix-dominated bacterial biofilm developed on stainless steel surface in a gasoline-contaminated hypoxic groundwater.

PubMed

Benedek, Tibor; Táncsics, András; Szabó, István; Farkas, Milán; Szoboszlay, Sándor; Fábián, Krisztina; Maróti, Gergely; Kriszt, Balázs

2016-05-01

Pump and treat systems are widely used for hydrocarbon-contaminated groundwater remediation. Although biofouling (formation of clogging biofilms on pump surfaces) is a common problem in these systems, scarce information is available regarding the phylogenetic and functional complexity of such biofilms. Extensive information about the taxa and species as well as metabolic potential of a bacterial biofilm developed on the stainless steel surface of a pump submerged in a gasoline-contaminated hypoxic groundwater is presented. Results shed light on a complex network of interconnected hydrocarbon-degrading chemoorganotrophic and chemolitotrophic bacteria. It was found that besides the well-known hydrocarbon-degrading aerobic/facultative anaerobic biofilm-forming organisms (e.g., Azoarcus, Leptothrix, Acidovorax, Thauera, Pseudomonas, etc.), representatives of Fe(2+)-and Mn(2+)-oxidizing (Thiobacillus, Sideroxydans, Gallionella, Rhodopseudomonas, etc.) as well as of Fe(3+)- and Mn(4+)-respiring (Rhodoferax, Geobacter, Magnetospirillum, Sulfurimonas, etc.) bacteria were present in the biofilm. The predominance of β-Proteobacteria within the biofilm bacterial community in phylogenetic and functional point of view was revealed. Investigation of meta-cleavage dioxygenase and benzylsuccinate synthase (bssA) genes indicated that within the biofilm, Azoarcus, Leptothrix, Zoogloea, and Thauera species are most probably involved in intrinsic biodegradation of aromatic hydrocarbons. Polyphasic analysis of the biofilm shed light on the fact that subsurface microbial accretions might be reservoirs of novel putatively hydrocarbon-degrading bacterial species. Moreover, clogging biofilms besides their detrimental effects might supplement the efficiency of pump and treat systems.

Principal Stratification — Uses and Limitations

PubMed Central

VanderWeele, Tyler J

2011-01-01

Pearl (2011) asked for the causal inference community to clarify the role of the principal stratification framework in the analysis of causal effects. Here, I argue that the notion of principal stratification has shed light on problems of non-compliance, censoring-by-death, and the analysis of post-infection outcomes; that it may be of use in considering problems of surrogacy but further development is needed; that it is of some use in assessing “direct effects”; but that it is not the appropriate tool for assessing “mediation.” There is nothing within the principal stratification framework that corresponds to a measure of an “indirect” or “mediated” effect. PMID:21841939

A fresh look at the freeze-all protocol: a SWOT analysis.

PubMed

Blockeel, Christophe; Drakopoulos, Panagiotis; Santos-Ribeiro, Samuel; Polyzos, Nikolaos P; Tournaye, Herman

2016-03-01

The 'freeze-all' strategy with the segmentation of IVF treatment, namely with the use of a GnRH antagonist protocol, GnRH agonist triggering, the elective cryopreservation of all embryos by vitrification and a frozen-thawed embryo transfer in a subsequent cycle, has become more popular. However, the approach still encounters drawbacks. In this opinion paper, a SWOT (strengths, weaknesses, opportunities and threats) analysis sheds light on the different aspects of this strategy. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Disciplined by the discipline: a social-epistemic fingerprint of the history of science.

PubMed

Vanderstraeten, Raf; Vandermoere, Frederic

2015-06-01

The scientific system is primarily differentiated into disciplines. While disciplines may be wide in scope and diverse in their research practices, they serve scientific communities that evaluate research and also grant recognition to what is published. The analysis of communication and publication practices within such a community hence allows us to shed light on the dynamics of this discipline. On the basis of an empirical analysis of Isis, we show how the process of discipline-building in history of science has led its practitioners to be socialized and sensitized in relatively strong intra-disciplinary terms--with minimal interdisciplinary openness.

Bubble Divergences: Sorting out Topology from Cell Structure

NASA Astrophysics Data System (ADS)

Bonzom, Valentin; Smerlak, Matteo

2012-02-01

We conclude our analysis of bubble divergences in the flat spinfoam model. In [arXiv:1008.1476] we showed that the divergence degree of an arbitrary two-complex Gamma can be evaluated exactly by means of twisted cohomology. Here, we specialize this result to the case where Gamma is the two-skeleton of the cell decomposition of a pseudomanifold, and sharpen it with a careful analysis of the cellular and topological structures involved. Moreover, we explain in detail how this approach reproduces all the previous powercounting results for the Boulatov-Ooguri (colored) tensor models, and sheds light on algebraic-topological aspects of Gurau's 1/N expansion.

Disaster Response on September 11, 2001 Through the Lens of Statistical Network Analysis.

PubMed

Schweinberger, Michael; Petrescu-Prahova, Miruna; Vu, Duy Quang

2014-05-01

The rescue and relief operations triggered by the September 11, 2001 attacks on the World Trade Center in New York City demanded collaboration among hundreds of organisations. To shed light on the response to the September 11, 2001 attacks and help to plan and prepare the response to future disasters, we study the inter-organisational network that emerged in response to the attacks. Studying the inter-organisational network can help to shed light on (1) whether some organisations dominated the inter-organisational network and facilitated communication and coordination of the disaster response; (2) whether the dominating organisations were supposed to coordinate disaster response or emerged as coordinators in the wake of the disaster; and (3) the degree of network redundancy and sensitivity of the inter-organisational network to disturbances following the initial disaster. We introduce a Bayesian framework which can answer the substantive questions of interest while being as simple and parsimonious as possible. The framework allows organisations to have varying propensities to collaborate, while taking covariates into account, and allows to assess whether the inter-organisational network had network redundancy-in the form of transitivity-by using a test which may be regarded as a Bayesian score test. We discuss implications in terms of disaster management.

Photon and neutron interrogation techniques for chemical explosives detection in air cargo: A critical review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Runkle, Robert C.; White, Timothy A.; Miller, Erin A.

Scanning cargo transported via aircraft ("air cargo") for explosive threats is a problem that, at present, lacks a comprehensive technical solution. While explosives detection in the baggage-scanning domain has a rich history that sheds light on potential solutions for air cargo, baggage scanning differs in several ways and thus one cannot look to the present array of technologies. Some contemporary solutions, like trace analysis, are not readily applied to cargo due to sampling challenges while the larger geometry of air cargo makes others less effective. This review article examines an array of interrogation techniques using photons and neutrons as incidentmore » particles. We first present a summary of the signatures and observables explosives provide and review how they have been exploited in baggage scanning. Following this is a description of the challenges posed by the air cargo application space. After considering interrogation sources, methods focused on transmission imaging, sub-surface examination and elemental characterization are described. It is our goal to shed light on the technical promise of each method while largely deferring questions that revolve around footprint, safety and conduct of operations. Our overarching intent is that a comprehensive understanding of potential techniques will foster development of a comprehensive solution.« less

Supercomputing Sheds Light on the Dark Universe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habib, Salman; Heitmann, Katrin

2012-11-15

At Argonne National Laboratory, scientists are using supercomputers to shed light on one of the great mysteries in science today, the Dark Universe. With Mira, a petascale supercomputer at the Argonne Leadership Computing Facility, a team led by physicists Salman Habib and Katrin Heitmann will run the largest, most complex simulation of the universe ever attempted. By contrasting the results from Mira with state-of-the-art telescope surveys, the scientists hope to gain new insights into the distribution of matter in the universe, advancing future investigations of dark energy and dark matter into a new realm. The team's research was named amore » finalist for the 2012 Gordon Bell Prize, an award recognizing outstanding achievement in high-performance computing.« less

Liquid Crystal Droplet-Based Amplification of Microvesicles that are Shed by Mammalian Cells

PubMed Central

Tan, Lie Na; Wiepz, Gregory J.; Miller, Daniel S.; Shusta, Eric V.; Abbott, Nicholas L.

2014-01-01

Membrane-derived microvesicles (MVs) shed by cells are being investigated for their role in intercellular communication and as potential biomarkers of disease, but facile and sensitive methods for their analysis do not exist. Here we demonstrate new principles for analysis of MVs that use micrometer-sized droplets of liquid crystals (LCs) to amplify MVs that are selectively captured via antibody-mediated interactions. The influence of the MVs on the micrometer-sized LC droplets is shown to be readily quantified via use of flow cytometry. The methodology was developed using MVs shed by epidermoid carcinoma A431 cells that contain epidermal growth factor receptor (EGFR) as an important and representative example of MVs containing signaling proteins that play a central role in cancer. The LC droplets were found to be sensitive to 106 MVs containing EGFR (relative to controls using isotype control antibody) and to possess a dynamic range of response across several orders of magnitude. Because the 100 nm-sized MVs captured via EGFR generate an optical response in the micrometer-sized LC droplets that can be readily detected by flow cytometry in light scattering mode, the approach possesses significant advantages over direct detection of MVs by flow cytometry. The LC droplets are also substantially more sensitive than techniques such as immunoblotting because the lipid-component of the MVs serves to amplify the antibody-mediated capture of the target proteins in the MVs. Other merits of the approach are defined and discussed in the paper. PMID:24667742

Photoreceptor disc shedding in the living human eye

PubMed Central

Kocaoglu, Omer P.; Liu, Zhuolin; Zhang, Furu; Kurokawa, Kazuhiro; Jonnal, Ravi S.; Miller, Donald T.

2016-01-01

Cone photoreceptors undergo a daily cycle of renewal and shedding of membranous discs in their outer segments (OS), the portion responsible for light capture. These physiological processes are fundamental to maintaining photoreceptor health, and their dysfunction is associated with numerous retinal diseases. While both processes have been extensively studied in animal models and postmortem eyes, little is known about them in the living eye, in particular human. In this study, we report discovery of the optical signature associated with disc shedding using a method based on adaptive optics optical coherence tomography (AO-OCT) in conjunction with post-processing methods to track and monitor individual cone cells in 4D. The optical signature of disc shedding is characterized by an abrupt transient loss in the cone outer segment tip (COST) reflection followed by its return that is axially displaced anteriorly. Using this signature, we measured the temporal and spatial properties of shedding events in three normal subjects. Average duration of the shedding event was 8.8 ± 13.4 minutes, and average length loss of the OS was 2.1 μm (7.0% of OS length). Prevalence of cone shedding was highest in the morning (14.3%) followed by the afternoon (5.7%) and evening (4.0%), with load distributed across the imaged patch. To the best of our knowledge these are the first images of photoreceptor disc shedding in the living retina. PMID:27895995

Peripheral Nerve Regeneration by Secretomes of Stem Cells from Human Exfoliated Deciduous Teeth.

PubMed

Sugimura-Wakayama, Yukiko; Katagiri, Wataru; Osugi, Masashi; Kawai, Takamasa; Ogata, Kenichi; Sakaguchi, Kohei; Hibi, Hideharu

2015-11-15

Peripheral nerve regeneration across nerve gaps is often suboptimal, with poor functional recovery. Stem cell transplantation-based regenerative therapy is a promising approach for axon regeneration and functional recovery of peripheral nerve injury; however, the mechanisms remain controversial and unclear. Recent studies suggest that transplanted stem cells promote tissue regeneration through a paracrine mechanism. We investigated the effects of conditioned media derived from stem cells from human exfoliated deciduous teeth (SHED-CM) on peripheral nerve regeneration. In vitro, SHED-CM-treated Schwann cells exhibited significantly increased proliferation, migration, and the expression of neuron-, extracellular matrix (ECM)-, and angiogenesis-related genes. SHED-CM stimulated neuritogenesis of dorsal root ganglia and increased cell viability. Similarly, SHED-CM enhanced tube formation in an angiogenesis assay. In vivo, a 10-mm rat sciatic nerve gap model was bridged by silicon conduits containing SHED-CM or serum-free Dulbecco's modified Eagle's medium. Light and electron microscopy confirmed that the number of myelinated axons and axon-to-fiber ratio (G-ratio) were significantly higher in the SHED-CM group at 12 weeks after nerve transection surgery. The sciatic functional index (SFI) and gastrocnemius (target muscle) wet weight ratio demonstrated functional recovery. Increased compound muscle action potentials and increased SFI in the SHED-CM group suggested sciatic nerve reinnervation of the target muscle and improved functional recovery. We also observed reduced muscle atrophy in the SHED-CM group. Thus, SHEDs may secrete various trophic factors that enhance peripheral nerve regeneration through multiple mechanisms. SHED-CM may therefore provide a novel therapy that creates a more desirable extracellular microenvironment for peripheral nerve regeneration.

Polarization properties of below-threshold harmonics from aligned molecules H2+ in linearly polarized laser fields.

PubMed

Dong, Fulong; Tian, Yiqun; Yu, Shujuan; Wang, Shang; Yang, Shiping; Chen, Yanjun

2015-07-13

We investigate the polarization properties of below-threshold harmonics from aligned molecules in linearly polarized laser fields numerically and analytically. We focus on lower-order harmonics (LOHs). Our simulations show that the ellipticity of below-threshold LOHs depends strongly on the orientation angle and differs significantly for different harmonic orders. Our analysis reveals that this LOH ellipticity is closely associated with resonance effects and the axis symmetry of the molecule. These results shed light on the complex generation mechanism of below-threshold harmonics from aligned molecules.

The doctor-patient relationship in rock and roll music.

PubMed

Lazarus, Arthur

2006-01-01

An analysis of rock songs in which physicians are central characters, combined with archival events and commentary from the singers and songwriters, sheds light on doctor-patient relationships as seen through popular culture. Rock and roll music attributes special psychological significance to physicians. Musicians project their personal problems through love songs and songs that deal with sex, drugs, and death. In rock songs, physicians frequently represent a cure for lovesickness. Rock musicians often die prematurely from self-inflicted behaviors, reaffirming the connection between their music and the medical profession.

INL’s TAP Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2017-06-22

The starting point for many consumer products is the industrial manufacture of platform chemicals. The recent boom in domestic shale gas production makes it possible to envision a new resource for chemical manufacturing. Catalysts are the accelerants behind most industrial chemical reactions. A sophisticated research technique using a Temporal Analysis of Products (or TAP) reactor can now help. By shedding light on a catalyst’s fundamental step-by-step process, a TAP reactor can help chemists and chemical engineers understand why a new catalyst works better in the lab than in the chemical plant.

Conformational landscape of a virus by single-particle X-ray scattering

DOE PAGES

Hosseinizadeh, Ahmad; Mashayekhi, Ghoncheh; Copperman, Jeremy; ...

2017-08-14

Using a manifold-based analysis of experimental diffraction snapshots from an X-ray free electron laser, we determine the three-dimensional structure and conformational landscape of the PR772 virus to a detector-limited resolution of 9 nm. Our results indicate that a single conformational coordinate controls reorganization of the genome, growth of a tubular structure from a portal vertex and release of the genome. Furthermore, these results demonstrate that single-particle X-ray scattering has the potential to shed light on key biological processes.

Coexistence Possibility of Biomass Industries

NASA Astrophysics Data System (ADS)

Jingchun, Sun; Junhu, Hou

This research aims to shed light on the mechanism of agricultural biomass material competition between the power generation and straw pulp industries and the impact on their coexistence. A two-stage game model is established to analyze including factors such as unit transportation cost, and profit spaces for the firms. The participants in the competition are a biomass supplier, a power plant and a straw pulp plant. From the industrial economics perspective, our analysis shows that raw material competition will bring about low coexistence possibility of the two industries based on agricultural residues in a circular collection area.

Russia as a Returning Donor--Four Roles in Development Assistance to Education

ERIC Educational Resources Information Center

Piattoeva, Nelli; Takala, Tuomas

2015-01-01

This article analyses the role of Russia in development assistance to education in light of the changing architecture of development assistance--the variety of positions identified with both "new" and "old" donor countries. We shed light on Russia's aims and agenda in the field of development assistance in general and…

ADP/ATP mitochondrial carrier MD simulations to shed light on the structural-dynamical events that, after an additional mutation, restore the function in a pathological single mutant.

PubMed

Di Marino, Daniele; Oteri, Francesco; Morozzo Della Rocca, Blasco; Chillemi, Giovanni; Falconi, Mattia

2010-12-01

Molecular dynamics simulations of the wild type bovine ADP/ATP mitochondrial carrier, and of the single Ala113Pro and double Ala113Pro/Val180Met mutants, embedded in a lipid bilayer, have been carried out for 30ns to shed light on the structural-dynamical changes induced by the Val180Met mutation restoring the carrier function in the Ala113Pro pathologic mutant. Principal component analysis indicates that, for the three systems, the protein dynamics is mainly characterized by the motion of the matrix loops and of the odd-numbered helices having a conserved proline in their central region. Analysis of the motions shows a different behaviour of single pathological mutant with respect of the other two systems. The single mutation induces a regularization and rigidity of the H3 helix, lost upon the introduction of the second mutation. This is directly correlated to the salt bridge distribution involving residues Arg79, Asp134 and Arg234, hypothesized to interact with the substrate. In fact, in the wild type simulation two stable inter-helices salt bridges, crucial for substrate binding, are present almost over all the simulation time. In line with the impaired ADP transport, one salt interaction is lost in the single mutant trajectory but reappears in the double mutant simulation, where a salt bridge network matching the wild type is restored. Other important structural-dynamical properties, such as the trans-membrane helices mobility, analyzed via the principal component analysis, are similar for the wild type and double mutant while are different for the single mutant, providing a mechanistic explanation for their different functional properties. Copyright © 2010 Elsevier Inc. All rights reserved.

Modelling the effect of heterogeneity of shedding on the within herd Coxiella burnetii spread and identification of key parameters by sensitivity analysis.

PubMed

Courcoul, Aurélie; Monod, Hervé; Nielen, Mirjam; Klinkenberg, Don; Hogerwerf, Lenny; Beaudeau, François; Vergu, Elisabeta

2011-09-07

Coxiella burnetii is the bacterium responsible for Q fever, a worldwide zoonosis. Ruminants, especially cattle, are recognized as the most important source of human infections. Although a great heterogeneity between shedder cows has been described, no previous studies have determined which features such as shedding route and duration or the quantity of bacteria shed have the strongest impact on the environmental contamination and thus on the zoonotic risk. Our objective was to identify key parameters whose variation highly influences C. burnetii spread within a dairy cattle herd, especially those related to the heterogeneity of shedding. To compare the impact of epidemiological parameters on different dynamical aspects of C. burnetii infection, we performed a sensitivity analysis on an original stochastic model describing the bacterium spread and representing the individual variability of the shedding duration, routes and intensity as well as herd demography. This sensitivity analysis consisted of a principal component analysis followed by an ANOVA. Our findings show that the most influential parameters are the probability distribution governing the levels of shedding, especially in vaginal mucus and faeces, the characteristics of the bacterium in the environment (i.e. its survival and the fraction of bacteria shed reaching the environment), and some physiological parameters related to the intermittency of shedding (transition probability from a non-shedding infected state to a shedding state) or to the transition from one type of shedder to another one (transition probability from a seronegative shedding state to a seropositive shedding state). Our study is crucial for the understanding of the dynamics of C. burnetii infection and optimization of control measures. Indeed, as control measures should impact the parameters influencing the bacterium spread most, our model can now be used to assess the effectiveness of different control strategies of Q fever within dairy cattle herds. Copyright © 2011 Elsevier Ltd. All rights reserved.

77 FR 62491 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

... understand the relationship between meteorological phenomena and road conditions, as well as public.... Additionally, the project will shed light upon the interrelationship between meteorological phenomena, road...

Computer Learning Through Piaget's Eyes.

ERIC Educational Resources Information Center

Huber, Leonard N.

1985-01-01

Discusses Piaget's pre-operational, concrete operational, and formal operational stages and shows how this information sheds light on how children approach computers and computing, particularly with the LOGO programming language. (JN)

The Effect of Format on Performance: Editing Text in Print versus Digital Formats

ERIC Educational Resources Information Center

Eden, Sigal; Eshet-Alkalai, Yoram

2013-01-01

In light of the present-day proliferation of digital texts and the increase in situations that require active digital text reading in learning, it is becoming increasingly important to shed light on the comparison between print and digital reading under active reading conditions. In this study, the active reading abilities of 93 university…

Age inclusive services or separate old age and working age services? A historical analysis from the formative years of old age psychiatry c.1940-1989.

PubMed

Hilton, Claire

2015-04-01

The Equality Act 2010 made it unlawful to discriminate in the provision of services on the grounds of age. This legislation is open to interpretation, but it is affecting the way older people's services are defined and provided. Historical evidence indicates that, since the 1940s, apart from psychiatrists working in dedicated old age services, most were unenthusiastic about working with mentally unwell older people and unsupportive of those who chose to do so. A historical analysis might shed light on current dilemmas about 'all age' or 'old age' services and inform decision-making on future mental health services.

Shedding light on thirteen years of darkness: content analysis of articles pertaining to transgender issues in marriage/couple and family therapy journals.

PubMed

Blumer, Markie L C; Green, Mary S; Knowles, Sarah J; Williams, April

2012-06-01

What is the extent to which marriage/couple and family therapy (M/CFT) journals address transgender issues and how many of them say they are inclusive of transgender persons when they are not? To answer these queries, a content analysis was conducted on articles published in M/CFT literature from 1997 through 2009. Of the 10,739 articles examined in 17 journals, only nine (0.0008%) focused on transgender issues or used gender variance as a variable. Findings support the assertion that transgender issues are ignored and marginalized by M/CFT scholars and researchers alike. © 2012 American Association for Marriage and Family Therapy.

The deuteron-radius puzzle is alive: A new analysis of nuclear structure uncertainties

NASA Astrophysics Data System (ADS)

Hernandez, O. J.; Ekström, A.; Nevo Dinur, N.; Ji, C.; Bacca, S.; Barnea, N.

2018-03-01

To shed light on the deuteron radius puzzle we analyze the theoretical uncertainties of the nuclear structure corrections to the Lamb shift in muonic deuterium. We find that the discrepancy between the calculated two-photon exchange correction and the corresponding experimentally inferred value by Pohl et al. [1] remain. The present result is consistent with our previous estimate, although the discrepancy is reduced from 2.6 σ to about 2 σ. The error analysis includes statistic as well as systematic uncertainties stemming from the use of nucleon-nucleon interactions derived from chiral effective field theory at various orders. We therefore conclude that nuclear theory uncertainty is more likely not the source of the discrepancy.

Carbon allocation to growth and storage in two evergreen species of contrasting successional status.

PubMed

Piper, Frida I; Sepúlveda, Paulina; Bustos-Salazar, Angela; Zúñiga-Feest, Alejandra

2017-05-01

A prevailing hypothesis in forest succession is that shade-tolerant species grow more slowly than shade-intolerant species, across light conditions, because they prioritize carbon (C) allocation to storage. We examined this hypothesis in a confamilial pair of species, including one of the fastest-growing tree species in the world ( Eucalyptus globulus ) and a shade-tolerant, slow-growing species ( Luma apiculata ). Seedlings were subjected to one out of four combinations of light (high vs. low) and initial defoliation (90% defoliated vs. nondefoliated) for four months. Growth, C storage concentration in different organs, leaf shedding, and lateral shoot formation were measured at the end of the experiment. Eucalyptus globulus grew faster than L. apiculata in high light, but not in low light. Both species had lower C storage concentration in low than in high light, but similar C storage concentrations in each light condition. Defoliation had no effect on C storage, except in the case of the old leaves of both species, which showed lower C storage levels in response to defoliation. Across treatments, leaf shedding was 96% higher in E. globulus than in L. apiculata while, in contrast, lateral shoot formation was 87% higher in L. apiculata . In low light, E. globulus prioritized C storage instead of growth, whereas L. apiculata prioritized growth and lateral branching. Our results suggest that shade tolerance depends on efficient light capture rather than C conservation traits. © 2017 Botanical Society of America.

Experimental study of oscillating plates in viscous fluids: Qualitative and quantitative analysis of the flow physics and hydrodynamic forces

NASA Astrophysics Data System (ADS)

Shrestha, Bishwash; Ahsan, Syed N.; Aureli, Matteo

2018-01-01

In this paper, we present a comprehensive experimental study on harmonic oscillations of a submerged rigid plate in a quiescent, incompressible, Newtonian, viscous fluid. The fluid-structure interaction problem is analyzed from both qualitative and quantitative perspectives via a detailed particle image velocimetry (PIV) experimental campaign conducted over a broad range of oscillation frequency and amplitude parameters. Our primary goal is to identify the effect of the oscillation characteristics on the mechanisms of fluid-structure interaction and on the dynamics of vortex shedding and convection and to elucidate the behavior of hydrodynamic forces on the oscillating structure. Towards this goal, we study the flow in terms of qualitative aspects of its pathlines, vortex shedding, and symmetry breaking phenomena and identify distinct hydrodynamic regimes in the vicinity of the oscillating structure. Based on these experimental observations, we produce a novel phase diagram detailing the occurrence of distinct hydrodynamic regimes as a function of relevant governing nondimensional parameters. We further study the hydrodynamic forces associated with each regime using both PIV and direct force measurement via a load cell. Our quantitative results on experimental estimation of hydrodynamic forces show good agreement against predictions from the literature, where numerical and semi-analytical models are available. The findings and observations in this work shed light on the relationship between flow physics, vortex shedding, and convection mechanisms and the hydrodynamic forces acting on a rigid oscillating plate and, as such, have relevance to various engineering applications, including energy harvesting devices, biomimetic robotic system, and micro-mechanical sensors and actuators.

Transcriptomic analysis suggests a key role for SQUAMOSA PROMOTER BINDING PROTEIN LIKE, NAC and YUCCA genes in the heteroblastic development of the temperate rainforest tree Gevuina avellana (Proteaceae).

PubMed

Ostria-Gallardo, Enrique; Ranjan, Aashish; Chitwood, Daniel H; Kumar, Ravi; Townsley, Brad T; Ichihashi, Yasunori; Corcuera, Luis J; Sinha, Neelima R

2016-04-01

Heteroblasty, the temporal development of the meristem, can produce diverse leaf shapes within a plant. Gevuina avellana, a tree from the South American temperate rainforest shows strong heteroblasty affecting leaf shape, transitioning from juvenile simple leaves to highly pinnate adult leaves. Light availability within the forest canopy also modulates its leaf size and complexity. Here we studied how the interaction between the light environment and the heteroblastic progression of leaves is coordinated in this species. We used RNA-seq on the Illumina platform to compare the range of transcriptional responses in leaf primordia of G. avellana at different heteroblastic stages and growing under different light environments. We found a steady up-regulation of SQUAMOSA PROMOTER BINDING PROTEIN LIKE (SPL), NAC, YUCCA and AGAMOUS-LIKE genes associated with increases in age, leaf complexity, and light availability. In contrast, expression of TCP, TPR and KNOTTED1 homeobox genes showed a sustained down-regulation. Additionally, genes involved in auxin synthesis/transport and jasmonate activity were differentially expressed, indicating an active regulation of processes controlled by these hormones. Our large-scale transcriptional analysis of the leaf primordia of G. avellana sheds light on the integration of internal and external cues during heteroblastic development in this species. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

Identification of Circular RNAs from the Parental Genes Involved in Multiple Aspects of Cellular Metabolism in Barley

PubMed Central

Darbani, Behrooz; Noeparvar, Shahin; Borg, Søren

2016-01-01

RNA circularization made by head-to-tail back-splicing events is involved in the regulation of gene expression from transcriptional to post-translational levels. By exploiting RNA-Seq data and down-stream analysis, we shed light on the importance of circular RNAs in plants. The results introduce circular RNAs as novel interactors in the regulation of gene expression in plants and imply the comprehensiveness of this regulatory pathway by identifying circular RNAs for a diverse set of genes. These genes are involved in several aspects of cellular metabolism as hormonal signaling, intracellular protein sorting, carbohydrate metabolism and cell-wall biogenesis, respiration, amino acid biosynthesis, transcription and translation, and protein ubiquitination. Additionally, these parental loci of circular RNAs, from both nuclear and mitochondrial genomes, encode for different transcript classes including protein coding transcripts, microRNA, rRNA, and long non-coding/microprotein coding RNAs. The results shed light on the mitochondrial exonic circular RNAs and imply the importance of circular RNAs for regulation of mitochondrial genes. Importantly, we introduce circular RNAs in barley and elucidate their cellular-level alterations across tissues and in response to micronutrients iron and zinc. In further support of circular RNAs' functional roles in plants, we report several cases where fluctuations of circRNAs do not correlate with the levels of their parental-loci encoded linear transcripts. PMID:27375638

Disability and HIV: What drives this relationship in Eastern and Southern Africa?

PubMed Central

Regondi, Ilaria; Naidoo, Kerisha

2013-01-01

The Eastern and Southern Africa (ESA) region is the epicentre of the global HIV epidemic and also home to a large number of people with disabilities. Both HIV and Disability are significant public health issues. While they are generally viewed as distinct and unrelated phenomena data seems to suggest that they are particularly closely intertwined in ESA. For the first time in history, by using the same disability indicator consistently, the publication of the World Report on Disability in 2011 has allowed for the comparison of disability data between countries, and across regions. This has the potential to shed some light on the relationship between disability and socio-economic markers and other health conditions in a way that was not possible previously. In the absence of disability and HIV-specific population-based surveys, this paper uses global socio-economic and HIV datasets and compares them to data contained in the most recent World Report on Disability. The analysis suggests that disability prevalence may be related to HIV-prevalence in ESA (Pearson 0.87). It identifies research and policy gaps and seeks to shed light on the relationship between the two phenomena. It concludes that, more than any other region in the world, ESA needs to ensure better data collection on disability and the inclusion of disability throughout its HIV programmes in order to provide a comprehensive and appropriate response to the epidemic. PMID:28729983

Monitoring dynamic interactions of tumor cells with tissue and immune cells in a lab-on-a-chip.

PubMed

Charwat, Verena; Rothbauer, Mario; Tedde, Sandro F; Hayden, Oliver; Bosch, Jacobus J; Muellner, Paul; Hainberger, Rainer; Ertl, Peter

2013-12-03

A complementary cell analysis method has been developed to assess the dynamic interactions of tumor cells with resident tissue and immune cells using optical light scattering and impedance sensing to shed light on tumor cell behavior. The combination of electroanalytical and optical biosensing technologies integrated in a lab-on-a-chip allows for continuous, label-free, and noninvasive probing of dynamic cell-to-cell interactions between adherent and nonadherent cocultures, thus providing real-time insights into tumor cell responses under physiologically relevant conditions. While the study of adherent cocultures is important for the understanding and suppression of metastatic invasion, the analysis of tumor cell interactions with nonadherent immune cells plays a vital role in cancer immunotherapy research. For the first time, the direct cell-to-cell interactions of tumor cells with bead-activated primary T cells were continuously assessed using an effector cell to target a cell ratio of 10:1.

Linnaeus' study of Swedish swidden cultivation: Pioneering ethnographic work on the 'economy of nature'.

PubMed

Dove, Michael R

2015-04-01

Carl Linnaeus' work on the 'economy of nature' was a major early development in what became the modern field of ecology. This analysis suggests that a key subject of this work that has been ignored or misunderstood for 250 years is the rural livelihoods, especially swidden (or slash-and-burn) agriculture, which Linnaeus studied during his expeditions through rural Sweden. Rereading his reports in the light of modern work on swiddens, political ecology, and the history of science affords a new appreciation of Linnaeus' insights into traditional systems of resource exploitation. The logic of nutrient cycling in swidden agriculture and its utilization of natural dynamics to serve human ends exemplify the principles of the 'economy of nature', and gave Linnaeus a philosophical basis for understanding and defending this system of agriculture as well as other rural resource use systems in Sweden. This analysis sheds new light on Linnaeus' ethnographic work, his view of folk environmental knowledge, and his often derided identification with Sweden's ethnic peoples.

Autonomous Onboard Science Data Analysis for Comet Missions

NASA Technical Reports Server (NTRS)

Thompson, David R.; Tran, Daniel Q.; McLaren, David; Chien, Steve A.; Bergman, Larry; Castano, Rebecca; Doyle, Richard; Estlin, Tara; Lenda, Matthew

2012-01-01

Coming years will bring several comet rendezvous missions. The Rosetta spacecraft arrives at Comet 67P/Churyumov-Gerasimenko in 2014. Subsequent rendezvous might include a mission such as the proposed Comet Hopper with multiple surface landings, as well as Comet Nucleus Sample Return (CNSR) and Coma Rendezvous and Sample Return (CRSR). These encounters will begin to shed light on a population that, despite several previous flybys, remains mysterious and poorly understood. Scientists still have little direct knowledge of interactions between the nucleus and coma, their variation across different comets or their evolution over time. Activity may change on short timescales so it is challenging to characterize with scripted data acquisition. Here we investigate automatic onboard image analysis that could act faster than round-trip light time to capture unexpected outbursts and plume activity. We describe one edge-based method for detect comet nuclei and plumes, and test the approach on an existing catalog of comet images. Finally, we quantify benefits to specific measurement objectives by simulating a basic plume monitoring campaign.

Monitoring water quality by remote sensing

NASA Technical Reports Server (NTRS)

Brown, R. L. (Principal Investigator)

1977-01-01

The author has identified the following significant results. A limited study was conducted to determine the applicability of remote sensing for evaluating water quality conditions in the San Francisco Bay and delta. Considerable supporting data were available for the study area from other than overflight sources, but short-term temporal and spatial variability precluded their use. The study results were not sufficient to shed much light on the subject, but it did appear that, with the present state of the art in image analysis and the large amount of ground truth needed, remote sensing has only limited application in monitoring water quality.

Social and Emotional Aging

PubMed Central

Charles, Susan; Carstensen, Laura L.

2014-01-01

The past several decades have witnessed unidimensional decline models of aging give way to life-span developmental models that consider how specific processes and strategies facilitate adaptive aging. In part, this shift was provoked by the stark contrast between findings that clearly demonstrate decreased biological, physiological, and cognitive capacity with those suggesting that people are generally satisfied in old age and experience relatively high levels of emotional well-being. In recent years, this supposed “paradox” of aging has been reconciled through careful theoretical analysis and empirical investigation. Viewing aging as adaptation sheds light on resilience, wellbeing, and emotional distress across adulthood. PMID:19575618

NORSTAR Project: Norfolk public schools student team for acoustical research

NASA Technical Reports Server (NTRS)

Fortunato, Ronald C.

1987-01-01

Development of the NORSTAR (Norfolk Public Student Team for Acoustical Research) Project includes the definition, design, fabrication, testing, analysis, and publishing the results of an acoustical experiment. The student-run program is based on a space flight organization similar to the Viking Project. The experiment will measure the scattering transfer of momentum from a sound field to spheres in a liquid medium. It is hoped that the experimental results will shed light on a difficult physics problem - the difference in scattering cross section (the overall effect of the sound wave scattering) for solid spheres and hollow spheres of differing wall thicknesses.

ENSO related variability in the Southern Hemisphere, 1948-2000

NASA Astrophysics Data System (ADS)

Ribera, Pedro; Mann, Michael E.

2003-01-01

The spatiotemporal evolution of Southern Hemisphere climate variability is diagnosed based on the use of the NCEP reanalysis (1948-2000) dataset. Using the MTM-SVD analysis method, significant narrowband variability is isolated from the multi-variate dataset. It is found that the ENSO signal exhibits statistically significant behavior at quasiquadrennial (3-6 yr) timescales for the full time-period. A significant quasibiennial (2-3 yr) timescales emerges only for the latter half of period. Analyses of the spatial evolution of the two reconstructed signals shed additional light on linkages between low and high-latitude Southern Hemisphere climate anomalies.

The evaluation of (social-)psychological comfort in clothing, a possible approach

NASA Astrophysics Data System (ADS)

Matté, L. L.; Broega, A. C.

2017-10-01

This paper presents the first results of a PhD research on psychological comfort of clothing. In order to understand and conceptualize the psychological aspects of clothing comfort, a variation of the Delphi Method was used to seek opinions from experts. This method was chosen because of its consensus-building features. The results were obtained from a qualitative text analysis, conducted over the experts’ responses to the first round of questions. The analytic process shed some light on the formation of the psychological comfort concept as well as the potential attributes to be evaluated when assessing this comfort dimension.

An agent-based model of centralized institutions, social network technology, and revolution.

PubMed

Makowsky, Michael D; Rubin, Jared

2013-01-01

This paper sheds light on the general mechanisms underlying large-scale social and institutional change. We employ an agent-based model to test the impact of authority centralization and social network technology on preference falsification and institutional change. We find that preference falsification is increasing with centralization and decreasing with social network range. This leads to greater cascades of preference revelation and thus more institutional change in highly centralized societies and this effect is exacerbated at greater social network ranges. An empirical analysis confirms the connections that we find between institutional centralization, social radius, preference falsification, and institutional change.

Defining the conserved internal architecture of a protein kinase.

PubMed

Kornev, Alexandr P; Taylor, Susan S

2010-03-01

Protein kinases constitute a large protein family of important regulators in all eukaryotic cells. All of the protein kinases have a similar bilobal fold, and their key structural features have been well studied. However, the recent discovery of non-contiguous hydrophobic ensembles inside the protein kinase core shed new light on the internal organization of these molecules. Two hydrophobic "spines" traverse both lobes of the protein kinase molecule, providing a firm but flexible connection between its key elements. The spine model introduces a useful framework for analysis of intramolecular communications, molecular dynamics, and drug design. Published by Elsevier B.V.

Light-Induced Capacitance Tunability in Ferroelectric Crystals.

PubMed

Páez-Margarit, David; Rubio-Marcos, Fernando; Ochoa, Diego A; Del Campo, Adolfo; Fernández, José F; García, José E

2018-06-25

The remote controlling of ferroic properties with light is nowadays a hot and highly appealing topic in materials science. Here, we shed light on some of the unresolved issues surrounding light-matter coupling in ferroelectrics. Our findings show that the capacitance and, consequently, its related intrinsic material property, i.e., the dielectric constant, can be reversibly adjusted through the light power control. High photodielectric performance is exhibited across a wide range of the visible light wavelength because of the wavelength-independence of the phenomenon. We have verified that this counterintuitive behavior can be strongly ascribed to the existence of "locally free charges" at domain wall.

Rethinking Normative Literacy Practices, Behaviors, and Interactions: Learning from Young Immigrant Boys

ERIC Educational Resources Information Center

Souto-Manning, Mariana; Dernikos, Bessie; Yu, Hae Min

2016-01-01

In light of the historical failure of boys of color in US schools, this article sheds light onto the ways in which normative discourses of literacy and learning shape the experiences of immigrant boys and how they are perceived and defined as un/successful students. Findings indicate that although these boys--deemed to be "at-risk" or…

Examining the Relationship between Career Decision Self-Efficacy, Ethnic Identity, and Academic Self-Concept and Achievement of African American High School Students

ERIC Educational Resources Information Center

Bounds, Patrice Sheri Robinson

2013-01-01

The exploration of African American adolescents' career development has gained increasing attention in light of literature describing various barriers impacting their educational and career development and goals. Social Cognitive Career Theory (SCCT) was used as a theoretical framework to help shed light on the contextual factors that influence…

Improving isotopic identification with INDRA Silicon-CsI(Tl) telescopes

NASA Astrophysics Data System (ADS)

Lopez, O.; Pârlog, M.; Borderie, B.; Rivet, M. F.; Lehaut, G.; Tabacaru, G.; Tassan-Got, L.; Pawłowski, P.; Bonnet, E.; Bougault, R.; Chbihi, A.; Dell'Aquila, D.; Frankland, J. D.; Galichet, E.; Gruyer, D.; La Commara, M.; Le Neindre, N.; Lombardo, I.; Manduci, L.; Marini, P.; Steckmeyer, J. C.; Verde, G.; Vient, E.; Wieleczko, J. P.; Indra Collaboration

2018-03-01

Profiting from previous works done with the INDRA multidetector on the description of the light response L of the CsI(Tl) crystals to different impinging nuclei, we propose an improved ΔE - L identification-calibration procedure for Silicon-Caesium Iodide (Si-CsI) telescopes, namely an Advanced Mass Estimate (AME) method. AME is compared to the usual, simple visual analysis of the corresponding two-dimensional map of ΔE - E type, by using INDRA experimental data from nuclear reactions induced by heavy ions in the Fermi energy regime. We show that the capability of such telescopes to identify both the atomic Z and the mass A numbers of light and heavy reaction products, can be quantitatively improved thanks to the proposed approach. This conclusion opens new possibilities to use INDRA for studying these reactions especially with radioactive beams. Indeed, the determination of the mass for charged reaction products becomes of paramount importance to shed light on the role of the isospin degree of freedom in the nuclear equation of state [1,2].

Identification of Key Pathways and Genes in the Dynamic Progression of HCC Based on WGCNA.

PubMed

Yin, Li; Cai, Zhihui; Zhu, Baoan; Xu, Cunshuan

2018-02-14

Hepatocellular carcinoma (HCC) is a devastating disease worldwide. Though many efforts have been made to elucidate the process of HCC, its molecular mechanisms of development remain elusive due to its complexity. To explore the stepwise carcinogenic process from pre-neoplastic lesions to the end stage of HCC, we employed weighted gene co-expression network analysis (WGCNA) which has been proved to be an effective method in many diseases to detect co-expressed modules and hub genes using eight pathological stages including normal, cirrhosis without HCC, cirrhosis, low-grade dysplastic, high-grade dysplastic, very early and early, advanced HCC and very advanced HCC. Among the eight consecutive pathological stages, five representative modules are selected to perform canonical pathway enrichment and upstream regulator analysis by using ingenuity pathway analysis (IPA) software. We found that cell cycle related biological processes were activated at four neoplastic stages, and the degree of activation of the cell cycle corresponded to the deterioration degree of HCC. The orange and yellow modules enriched in energy metabolism, especially oxidative metabolism, and the expression value of the genes decreased only at four neoplastic stages. The brown module, enriched in protein ubiquitination and ephrin receptor signaling pathways, correlated mainly with the very early stage of HCC. The darkred module, enriched in hepatic fibrosis/hepatic stellate cell activation, correlated with the cirrhotic stage only. The high degree hub genes were identified based on the protein-protein interaction (PPI) network and were verified by Kaplan-Meier survival analysis. The novel five high degree hub genes signature that was identified in our study may shed light on future prognostic and therapeutic approaches. Our study brings a new perspective to the understanding of the key pathways and genes in the dynamic changes of HCC progression. These findings shed light on further investigations.

Multi Vitamin E: E-lusive E-ffects

PubMed Central

2015-01-01

Investigations into vitamin E’s anti-inflammatory effects must be more comprehensive: Dr Joan Cook-Mills explains how their research could redefine medical perceptions and shed new light on previous studies PMID:27175228

Network analysis reveals the recognition mechanism for complex formation of mannose-binding lectins

NASA Astrophysics Data System (ADS)

Jian, Yiren; Zhao, Yunjie; Zeng, Chen

The specific carbohydrate binding of lectin makes the protein a powerful molecular tool for various applications including cancer cell detection due to its glycoprotein profile on the cell surface. Most biologically active lectins are dimeric. To understand the structure-function relation of lectin complex, it is essential to elucidate the short- and long-range driving forces behind the dimer formation. Here we report our molecular dynamics simulations and associated dynamical network analysis on a particular lectin, i.e., the mannose-binding lectin from garlic. Our results, further supported by sequence coevolution analysis, shed light on how different parts of the complex communicate with each other. We propose a general framework for deciphering the recognition mechanism underlying protein-protein interactions that may have potential applications in signaling pathways.

Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)

PubMed Central

Munster, Vincent J.; Adney, Danielle R.; van Doremalen, Neeltje; Brown, Vienna R.; Miazgowicz, Kerri L.; Milne-Price, Shauna; Bushmaker, Trenton; Rosenke, Rebecca; Scott, Dana; Hawkinson, Ann; de Wit, Emmie; Schountz, Tony; Bowen, Richard A.

2016-01-01

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential of Betacoronaviruses. Investigations into the origin of MERS-CoV have focused on two potential reservoirs: bats and camels. Here, we investigated the role of bats as a potential reservoir for MERS-CoV. In vitro, the MERS-CoV spike glycoprotein interacted with Jamaican fruit bat (Artibeus jamaicensis) dipeptidyl peptidase 4 (DPP4) receptor and MERS-CoV replicated efficiently in Jamaican fruit bat cells, suggesting there is no restriction at the receptor or cellular level for MERS-CoV. To shed light on the intrinsic host-virus relationship, we inoculated 10 Jamaican fruit bats with MERS-CoV. Although all bats showed evidence of infection, none of the bats showed clinical signs of disease. Virus shedding was detected in the respiratory and intestinal tract for up to 9 days. MERS-CoV replicated transiently in the respiratory and, to a lesser extent, the intestinal tracts and internal organs; with limited histopathological changes observed only in the lungs. Analysis of the innate gene expression in the lungs showed a moderate, transient induction of expression. Our results indicate that MERS-CoV maintains the ability to replicate in bats without clinical signs of disease, supporting the general hypothesis of bats as ancestral reservoirs for MERS-CoV. PMID:26899616

Axial-Current Matrix Elements in Light Nuclei from Lattice QCD

NASA Astrophysics Data System (ADS)

Savage, M.; Beane, S.; Chang, E.; Davoudi, Z.; Detmold, W.; Orginos, K.; Shanahan, P.; Tiburzi, B.; Wagman, M.; Winter, F.; Nplqcd Collaboration

I present results from the first lattice QCD calculations of axial-current matrix elements in light nuclei, performed by the NPLQCD collaboration. Precision calculations of these matrix elements, and the subsequent extraction of multi-nucleon axial-current operators, are essential in refining theoretical predictions of the proton-proton fusion cross section, neutrino-nucleus cross sections and $\\beta\\beta$-decay rates of nuclei. In addition, they are expected to shed light on the phenomenological quenching of $g_A$ that is required in nuclear many-body calculations.

Modeling of low-finesse, extrinsic fiber optic Fabry-Perot white light interferometers

NASA Astrophysics Data System (ADS)

Ma, Cheng; Tian, Zhipeng; Wang, Anbo

2012-06-01

This article introduces an approach for modeling the fiber optic low-finesse extrinsic Fabry-Pérot Interferometers (EFPI), aiming to address signal processing problems in EFPI demodulation algorithms based on white light interferometry. The main goal is to seek physical interpretations to correlate the sensor spectrum with the interferometer geometry (most importantly, the optical path difference). Because the signal demodulation quality and reliability hinge heavily on the understanding of such relationships, the model sheds light on optimizing the sensor performance.

History of Hubble Space Telescope (HST)

NASA Image and Video Library

1969-01-01

This image of the Egg Nebula, also known as CRL-2688 and located roughly 3,000 light-years from us, was taken in red light with the Wide Field Planetary Camera 2 (WF/PC2) aboard the Hubble Space Telescope (HST). The image shows a pair of mysterious searchlight beams emerging from a hidden star, crisscrossed by numerous bright arcs. This image sheds new light on the poorly understood ejection of stellar matter that accompanies the slow death of Sun-like stars. The image is shown in false color.

23. RW Meyer Sugar Mill: 18761889. Boiling House Interior, 1878. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. RW Meyer Sugar Mill: 1876-1889. Boiling House Interior, 1878. View: North Wall of boiling house. In the original structure the three windows on the right admitted light and air from the outside. A shed occupied the left side of the wall outside (hence no windows). in 1881 the construction of the cooling shed closed in the right three windows. The sorghum is in the foreground. The centrifugals are in the left rear. - R. W. Meyer Sugar Mill, State Route 47, Kualapuu, Maui County, HI

WHAT'S the Matter at Rhic?

NASA Astrophysics Data System (ADS)

de Cassagnac, Raphael Granier

I present here a concise review of the experimental results obtained at the Relativistic Heavy Ion Collider (RHIC), which shed light on the hot and dense quark gluon matter produced at these high temperature and density conditions.

Clinical Trials Shed Light on Minority Health

MedlinePlus

... determine whether FDA approves a manufacturer’s application for marketing approval. "Potential racial, ethnic and other differences in ... patient advocates and the scientific community to discuss strategies for increasing the participation of women and minorities ...

Study Sheds New Light on Postmenopausal Breast Cancer Risk | Poster

Cancer.gov

A collaborative study conducted at the Frederick National Lab and published in Cancer Research has provided new insight as to why elevated estrogen levels are associated with an increased risk of breast cancer.

Microfabrics in Siliceous Hotsprings: Yellowstone National Park, Wyoming

NASA Technical Reports Server (NTRS)

Guidry, S. A.; Chafetz, H. S.; Westall, F.

2001-01-01

Microfabrics shed light on the mechanisms governing siliceous sinter precipitation, the profound effects of microorganisms, as well as a conventional facies model for siliceous hotsprings. Additional information is contained in the original extended abstract.

Poverty-Exploitation-Alienation.

ERIC Educational Resources Information Center

Bronfenbrenner, Martin

1980-01-01

Illustrates how knowledge derived from the discipline of economics can be used to help shed light on social problems such as poverty, exploitation, and alienation, and can help decision makers form policy to minimize these and similar problems. (DB)

Using High-Powered Laser, Scientists Record Images of Chemical Interactions in RNA | Poster

Cancer.gov

A recent study at the Department of Energy’s Stanford Linear Accelerator Center National Accelerator Laboratory has literally shed new light on the structural interactions between RNA and another biomolecule.

Maths meets myths

NASA Astrophysics Data System (ADS)

Kenna, Ralph; Mac Carron, Pádraig

2016-06-01

Scholars have long debated whether the Sagas of Icelanders - ancient narratives set in the Viking Age - are fact or fiction. Ralph Kenna and Pádraig Mac Carron analysed the structures of the saga societies to shed light on this question.

1. General view looking northeast showing (from left to right) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. General view looking northeast showing (from left to right) storage shed, keepers' dwelling, and tower with attached oil house. - Bodie Island Light Station, Off Highway 12, Nags Head, Dare County, NC

Vortex shedding in bileaflet heart valve prostheses.

PubMed

Gross, J M; Shermer, C D; Hwang, N H

1988-01-01

A dynamic study of two geometrically similar bileaflet heart valve prostheses (HVP) was performed using a physiologic mock circulatory flow loop. The HVPs studied were the 25 mm St. Jude Medical (SJM) and the 25 mm Carbomedics (CMI) in the aortic position and the 27 mm SJM and 27 mm CMI in the mitral position. All data were collected at a heart rate of 70 beats/min and a cardiac output of 5.0 L/min. Flow visualization was conducted in the transparent flow chambers of the pulsatile mock circulatory flow loop using a 15 mW He-Ne laser light source. A cylindrical lens and optics system converted the incident laser beam into a thin parallel light plane, and 420 microns tracer particles were suspended in the testing fluid to illuminate the flow field at selected planes. Frame-by-frame analysis of the 16 mm high-speed cine provides detailed phasic flow patterns in the vicinity of the HVP. A series of still photographs of flow patterns, taken at approximately 22.5 degrees phase intervals, are sequentially presented for each HVP. In the aortic position, a Karman-like vortex pattern appears downstream of the SJM at the end of the ejection phase. The CMI exhibits a rather symmetrical ejection flow pattern that turns into random motion immediately after the onset of ejection. In the mitral position, the SJM again exhibits a strong core flow during ventricular filling, whereas the CMI produces a more diffuse pattern during the same period. A pair of vortices shed from both the SJM and CMI are clearly visible toward the end of the ventricular filling phase. The vortex mechanisms are discussed in light of leaflet boundary layer formation.

The distribution of actin immunoreactivity in rhabdomeres of tipulid flies in relation to extracellular membrane shedding.

PubMed

Blest, A D; Stowe, S; Clausen, J A; Carter, M

1991-09-01

Rhabdomeres of tipulid flies lose membrane during turnover from a 'shedding zone' composed of microvillar tips. These distal domains lack intramicrovillar cytoskeletons and appear to be empty sacs of membrane. Recent concerns about the role of ninaC mechano-enzymes in the architecture of dipteran rhabdomeral microvilli and the dynamic role that they may play in the creation of shedding zones demand an examination of the distribution of actin in tipulid rhabdomeres. We compared rhabdomeres from tipulid retinae incubated before fixation for immunocytochemistry in a buffer without additives and a stabilising buffer that contained a cocktail of cysteine protease inhibitors; both were challenged by an anti-actin antibody for immunogold labelling after embedding in LR White Resin. Shedding zones thus processed collapse to structureless detritus. Stabilised and unstabilized shedding zones were immunonegative to anti-actin. To ensure that the negative results were not consequent upon conformational changes generated by the processing protocol, we examined microvilli of degenerating rhabdomeres of the Drosophila light-dependent retinal degeneration mutant rdgBKS222 (which separate and collapse without creating a shedding zone) and found the detritus they generate to be immunopositive to anti-actin. Stabilised and unstabilized regions of basal regions of tipulid rhabdomeres were equally immunopositive. We infer that (a) actin is absent from shedding zones; (b) actin is not degraded by microvillar cysteine proteases. The implications of these conclusions are discussed in relation to some functional models of arthropod photoreceptor microvilli.

The meaning of home for ageing women living alone: An evolutionary concept analysis.

PubMed

Barry, Arro; Heale, Roberta; Pilon, Roger; Lavoie, Anne Marise

2018-05-01

The concept of home to women ageing should be visited in the light of ongoing cultural, political, temporal and disciplinary evolutions. In part, to compliment policies increasing focus on supporting older adults to age in place and a growing attention on the home as a place where healthcare is designed and provided. The following concept analysis utilises Rodgers' evolutionary method to inductively analyse literature in order to elicit the meaning and experience of home among older women who are ageing at home. Literature was collected over an 18-month period during 2014-2015 and the sample was made up of 49 articles. The analysis led to the concept of home among women ageing in communities to be defined by four attributes. These attributes are home as (i) a resource, (ii) an attachment, (iii) the precariousness of maintaining and sustaining home and (iv) a cultural expectation. This analysis of the meaning and experience of home among women ageing at home has shed light on the needs for this group of women, while highlighting the need to continue to further clarify and define the concept through research. © 2017 John Wiley & Sons Ltd.

Age inclusive services or separate old age and working age services? A historical analysis from the formative years of old age psychiatry c.1940–1989

PubMed Central

Hilton, Claire

2015-01-01

The Equality Act 2010 made it unlawful to discriminate in the provision of services on the grounds of age. This legislation is open to interpretation, but it is affecting the way older people’s services are defined and provided. Historical evidence indicates that, since the 1940s, apart from psychiatrists working in dedicated old age services, most were unenthusiastic about working with mentally unwell older people and unsupportive of those who chose to do so. A historical analysis might shed light on current dilemmas about ‘all age’ or ‘old age’ services and inform decision-making on future mental health services. PMID:26191440

The Bibliometric Analysis Of Literature On Museum Studies

NASA Astrophysics Data System (ADS)

Kuo, C. W.; Yang, Y. H.

2015-08-01

Museum studies, is the study of museums, museum curation, and how and why museums developed into their institutional role in education and culture through scientific, social, political and other related forces. The purpose of this study is to shed light on the application trends of the international literature related to museum studies on the SCIE, SSCI, and AHCI databases between 1995 and 2014 using a bibliometric technique and citation analysis. The results of this study reveal that influences of the literature related to museum studies on other subject areas continue to expand. Considering the publication of major countries, subject areas, journal and institutions, the results also discussed that the future trend through analysing most cited articles. Moreover, 12 core journal lists are identified by Bradford's law.

Pharmacology and psychiatry at the origins of Greek medicine: The myth of Melampus and the madness of the Proetides.

PubMed

Olivieri, Matteo F; Marzari, Francesca; Kesel, Andreas J; Bonalume, Laura; Saettini, Francesco

2017-01-01

Melampus is a seer-healer of Greek myth attributed with having healed the young princesses of Argos of madness. Analysis of this legend and its sources sheds light on the early stages of the "medicalizing" shift in the history of ancient Greek medicine. Retrospective psychological diagnosis suggests that the descriptions of the youths' madness rose from actual observation of behavioral and mental disorders. Melampus is credited with having healed them by administering hellebore. Pharmacological analysis of botanical specimens proves that Helleborus niger features actual neurological properties effective in the treatment of mental disorders. The discussion aims at examining the rational aspects of the treatment of mental conditions in Greco-Roman antiquity.

The positioning of sustainability within residential property marketing.

PubMed

Kriese, Ulrich; Scholz, Roland W

2011-01-01

This article investigates the evolution of sustainability positioning in residential property marketing to shed light on the specific role and responsibility of housebuilders and housing investors in urban development. To this end, an analysis is made of housing advertisements published in Basel, Switzerland, over a period of more than 100 years. The paper demonstrates how to draw successfully on advertisements to discern sustainability patterns in housing, using criteria situated along the dimensions building, location and people. Cluster analysis allows five clusters of sustainability positioning to be described—namely, good location, green building, comfort living, pre-sustainability and sustainability. Investor and builder types are differently located in these clusters. Location emerges as an issue which, to a large extent, is advertised independently from other sustainability issues.

Newly Graduated Nurses' Competence and Individual and Organizational Factors: A Multivariate Analysis.

PubMed

Numminen, Olivia; Leino-Kilpi, Helena; Isoaho, Hannu; Meretoja, Riitta

2015-09-01

To study the relationships between newly graduated nurses' (NGNs') perceptions of their professional competence, and individual and organizational work-related factors. A multivariate, quantitative, descriptive, correlation design was applied. Data collection took place in November 2012 with a national convenience sample of 318 NGNs representing all main healthcare settings in Finland. Five instruments measured NGNs' perceptions of their professional competence, occupational commitment, empowerment, practice environment, and its ethical climate, with additional questions on turnover intentions, job satisfaction, and demographics. Descriptive statistics summarized the demographic data, and inferential statistics multivariate path analysis modeling estimated the relationships between the variables. The strongest relationship was found between professional competence and empowerment, competence explaining 20% of the variance of empowerment. The explanatory power of competence regarding practice environment, ethical climate of the work unit, and occupational commitment, and competence's associations with turnover intentions, job satisfaction, and age, were statistically significant but considerably weaker. Higher competence and satisfaction with quality of care were associated with more positive perceptions of practice environment and its ethical climate as well as higher empowerment and occupational commitment. Apart from its association with empowerment, competence seems to be a rather independent factor in relation to the measured work-related factors. Further exploration would deepen the knowledge of this relationship, providing support for planning educational and developmental programs. Research on other individual and organizational factors is warranted to shed light on factors associated with professional competence in providing high-quality and safe care as well as retaining new nurses in the workforce. The study sheds light on the strength and direction of the significantly associated work-related factors. Nursing professional bodies, managers, and supervisors can use the findings in planning orientation programs and other occupational interventions for NGNs. © 2015 Sigma Theta Tau International.

Tracking dynamics of photoreceptor disc shedding with adaptive optics-optical coherence tomography

NASA Astrophysics Data System (ADS)

Zhang, Furu; Liu, Zhuolin; Kurokawa, Kazuhiro; Miller, Donald T.

2017-02-01

Absorption of light by photoreceptors initiates vision, but also leads to accumulation of toxic photo-oxidative compounds in the photoreceptor outer segment (OS). To prevent this buildup, small packets of OS discs are periodically pruned from the distal end of the OS, a process called disc shedding. Unfortunately dysfunction in any part of the shedding event can lead to photoreceptor and RPE dystrophy, and has been implicated in numerous retinal diseases, including age related macular degeneration and retinitis pigmentosa. While much is known about the complex molecular and signaling pathways that underpin shedding, all of these advancements have occurred in animal models using postmortem eyes. How these translate to the living retina and to humans remain major obstacles. To that end, we have recently discovered the optical signature of cone OS disc shedding in the living human retina, measured noninvasively using optical coherence tomography equipped with adaptive optics in conjunction with post processing methods to track and monitor individual cones in 4D. In this study, we improve on this method in several key areas: increasing image acquisition up to MHz A-scan rates, improving reliability to detect disc shedding events, establishing system precision, and developing cone tracking for use across the entire awake cycle. Thousands of cones were successfully imaged and tracked over the 17 hour period in two healthy subjects. Shedding events were detected in 79.5% and 77.4% of the tracked cones. Similar to previous animal studies, shedding prevalence exhibited a diurnal rhythm. But we were surprised to find that for these two subjects shedding occurred across the entire day with broad, elevated frequency in the morning and decreasing frequency as the day progressed. Consistent with this, traces of the average cone OS length revealed shedding dominated in the morning and afternoon and renewal in the evening.

[Light and hens as attraction factors of Nyssomyia whitmani in a rural area, Southern Brazil].

PubMed

Teodoro, Ueslei; Lonardoni, Maria Valdrinez Campana; Silveira, Thaís Gomes Verzignassi; Dias, Alessandra de Cassia; Abbas, Milia; Alberton, Dayane; Santos, Demilson Rodrigues dos

2007-06-01

To verify the influence of traps with electric light and hens as factors that attract sandflies and compare results between capture methods. The study was conducted in the Palmital Farm, Southern Brazil. Sandfly collections were conducted with Falcão traps and an electric aspirator, fortnightly, between 8 p.m. and 11 p.m. in the presence or absence of light and hens in peridomiciliary areas, from September 1998 to June 1999. A total of 43,767 specimens from eight species of sandflies were collected: Nyssomyia whitmani, N. neivai and Migonemyia migonei constituting 99.9% of the total collected, with predominance of N. whitmani. The number of this species collected inside the hen's shed in the presence of hens (21,045) was greater than in their absence (10,434). In the presence of hens, with distinct intensities of light, a larger number of N. whitmani samples were collected with 3W light. In the presence of hens and light (3W), the number of N. whitmani collected with the electric aspirator (5,141) was superior to that collected with the Falcão trap (1,675). In the absence of light, with or without the presence hens, there was no difference between the numbers of N. whitmani collected with the electric aspirator or the Falcão trap. Hens and electric light together attract more N. whitmani to peridomicilary areas. The number of N. whitmani collected with an electric aspirator inside a hen's shed with the presence of hens and light is greater than those collected with a Falcão trap in the same conditions.

Partial protein domains: evolutionary insights and bioinformatics challenges.

PubMed

Kelley, Lawrence A; Sternberg, Michael J E

2015-05-19

Protein domains are generally thought to correspond to units of evolution. New research raises questions about how such domains are defined with bioinformatics tools and sheds light on how evolution has enabled partial domains to be viable.

Dynamic constitutional frameworks for DNA biomimetic recognition.

PubMed

Catana, Romina; Barboiu, Mihail; Moleavin, Ioana; Clima, Lilia; Rotaru, Alexandru; Ursu, Elena-Laura; Pinteala, Mariana

2015-02-07

Linear and cross-linked dynamic constitutional frameworks generated from reversibly interacting linear PEG/core constituents and cationic sites shed light on the dominant coiling versus linear DNA binding behaviours, closer to the histone DNA binding wrapping mechanism.

How I Created the Theory of Relativity.

ERIC Educational Resources Information Center

Ono, Yoshimasa A.

1982-01-01

This translation of a lecture given in Kyoto (Japan) on 14 December l922 sheds light on Einstein's path to the theory of relativity and offers insights into many other aspects of his work on relativity. (Author/JN)

Study Sheds Light on Role of Inherited Mutations in Childhood Cancer

Cancer.gov

In the most comprehensive study of its kind conducted to date, more than 8 percent of children with cancer were found to have inherited genetic mutations associated with a predisposition to the disease.

More Life-Science Experiments For Spacelab

NASA Technical Reports Server (NTRS)

Savage, P. D., Jr.; Dalton, B.; Hogan, R.; Leon, H.

1991-01-01

Report describes experiments done as part of Spacelab Life Sciences 2 mission (SLS-2). Research planned on cardiovascular, vestibular, metabolic, and thermal responses of animals in weightlessness. Expected to shed light on effects of prolonged weightlessness on humans.

This is an exciting time in the treatment of lymphoma.

MedlinePlus

... Cover Story: Leukemia/Lymphoma "This is an exciting time in the treatment of lymphoma." Past Issues / Summer ... best medication for each patient, indicates the best time for treatments, and sheds light on the patient's ...

Mechanisms for radiation damage in DNA. Progress report, January 1, 1980-December 31, 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sevilla, M D

1980-09-01

In this project several mechanisms are proposed for radiation damage to DNA constituents and DNA, and a series of experiments detailed utilizing electron spin resonance spectrometry to test the proposed mechanisms. Under current investigation are irradiated systems of DNA constituents which may shed light on indirect effects. In addition, studies of radiation effects on lipids have been undertaken which will shed light on the only other proposed site for cell kill, the membrane. Studies completed during the past year are: (1) ..pi.. cations produced in DNA bases by attack of oxidizing radicals; (2) INDO studies of radicals produced in peptidesmore » and carboxylic acid model compounds; (3) electron reactions with carboxylic acids, ketones and aldehydes; and (4) ..gamma..-irradiation of esters and triglycerides. Progress has been made this year in a study of radicals generated in model compounds for the sugar-phosphate backbone.« less

Necroptosis in acute kidney injury: a shedding light

PubMed Central

Wang, S; Zhang, C; Hu, L; Yang, C

2016-01-01

Acute kidney injury (AKI) is a common and severe clinical condition with a heavy healthy burden around the world. In spite of supportive therapies, the mortality associated with AKI remains high. Our limited understanding of the complex cell death mechanism in the process of AKI impedes the development of desirable therapeutics. Necroptosis is a recently identified novel form of cell death contributing to numerable diseases and tissue damages. Increasing evidence has suggested that necroptosis has an important role in the pathogenesis of various types of AKI. Therefore, we present here the signaling pathways and main regulators of necroptosis that are potential candidate for therapeutic strategies. Moreover, we emphasize on the potential role and corresponding mechanisms of necroptosis in AKI based on recent advances, and also discuss the possible therapeutic regimens based on manipulating necroptosis. Taken together, the progress in this field sheds new light into the prevention and management of AKI in clinical practice. PMID:26938298

Exploring the Photovoltaic Properties of Metal Bipyridine Complexes (Metal = Fe, Zn, Cr, and Ru) by Density Functional Theory

NASA Astrophysics Data System (ADS)

Irfan, Ahmad; Abbas, Ghulam

2018-03-01

The synthesis and characterisation of mononuclear Fe complexes were carried out by using bipyridine (Compound 1) at ambient conditions. Additionally, three more derivatives were designed by substituting the central Fe metal with Zn, Cr, and Ru (Compound 2, Compound 3, and Compound 4), respectively. The ground state geometry calculations were carried out by using density functional theory (DFT) at B3LYP/6-31G** (LANL2DZ) level of theory. We shed light on the frontier molecular orbitals, electronic properties, photovoltaic parameters, and structure-property relationship. The open-circuit voltage is a promising parameter that considerably affects the photovoltaic performance; thus, we have estimated its value by considering the complexes as donors whereas TiO2 and/or Si were used as acceptors. The solar cell performance behaviour was also studied by shedding light on the band alignment and energy level offset.

Shedding light on moths: shorter wavelengths attract noctuids more than geometrids

PubMed Central

Somers-Yeates, Robin; Hodgson, David; McGregor, Peter K.; Spalding, Adrian; ffrench-Constant, Richard H.

2013-01-01

With moth declines reported across Europe, and parallel changes in the amount and spectra of street lighting, it is important to understand exactly how artificial lights affect moth populations. We therefore compared the relative attractiveness of shorter wavelength (SW) and longer wavelength (LW) lighting to macromoths. SW light attracted significantly more individuals and species of moth, either when used alone or in competition with LW lighting. We also found striking differences in the relative attractiveness of different wavelengths to different moth groups. SW lighting attracted significantly more Noctuidae than LW, whereas both wavelengths were equally attractive to Geometridae. Understanding the extent to which different groups of moth are attracted to different wavelengths of light will be useful in determining the impact of artificial light on moth populations. PMID:23720524

Coxiella burnetii shedding routes and antibody response after outbreaks of Q fever-induced abortion in dairy goat herds.

PubMed

Rousset, Elodie; Berri, Mustapha; Durand, Benoit; Dufour, Philippe; Prigent, Myriam; Delcroix, Thibault; Touratier, Anne; Rodolakis, Annie

2009-01-01

Q fever is a zoonosis caused by Coxiella burnetii, a bacterium largely carried by ruminants and shed into milk, vaginal mucus, and feces. The main potential hazard to humans and animals is due to shedding of bacteria that can then persist in the environment and be aerosolized. The purpose of this study was to evaluate shedding after an outbreak of Q fever abortion in goat herds and to assess the relationship with the occurrence of abortions and antibody responses. Aborting and nonaborting goats were monitored by PCR for C. burnetii shedding 15 and 30 days after the abortion episodes. PCR analysis of all samples showed that 70% (n = 50) of the aborting and 53% (n = 70) of the nonaborting goats were positive. C. burnetii was shed into vaginal mucus, feces, and milk of 44%, 21%, and 38%, respectively, of goats that aborted and 27%, 20%, and 31%, respectively, of goats that delivered normally. Statistical comparison of these shedding results did not reveal any difference between these two groups. PCR results obtained for the vaginal and fecal routes were concordant in 81% of cases, whereas those for milk correlated with only 49% of cases with either vaginal or fecal shedding status. Serological analysis, using enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence assay (IFA), and complement fixation tests, showed that at least 24% of the seronegative goats shed bacteria. Positive vaginal and fecal shedding, unlike positive milk shedding, was observed more often in animals that were weakly positive or negative by ELISA or IFA. Two opposite shedding trends were thus apparent for the milk and vaginal-fecal routes. Moreover, this study showed that a nonnegligible proportion of seronegative animals that delivered normally could excrete C. burnetii.

Delineating resource sheds in aquatic ecosystems (presentation)

EPA Science Inventory

Analysis of spatially-explicit ecological phenomena in aquatic ecosystems is impeded by a lack of knowledge of, and tools to delimit, spatial patterns of material supply to point locations. Here we apply the concept of "resource sheds" to coasts and watersheds. Resource sheds ar...

Facies Analysis of the Tandoǧdu Travertines, Van, Eastern Anatolia, Turkey: implications for the active tectonic deformation behind the formation and evolution of the travertines

NASA Astrophysics Data System (ADS)

Yesilova, Cetin; Yesilova, Pelin; Aclan, Mustafa; Gülyüz, Nilay

2017-04-01

In this study, stratigraphic and sedimentologic characteristics of Tandoǧdu travertines exposing at the 13 km southwest of Başkale, Van were examined. In this respect, we shed light on their formation conditions and depositional environment by determining their morphological characteristics and analyzing their facies distribution. In addition, kinematic studies were conducted by collecting structural data from the structures hosting the travertines. Tandoǧdu travertines having bed type and ridge type travertines have 5 distinct lithofacies based on the studies conducted. These are: (1) crystalline crust facies, (2) coated bubble facies, (3) paper-thin raft type facies, (4) lithoclast - breccia facies and (5) paleosoil facies. According to the examination of their morphologies and lithofacies; lithofacies were developed depending on the temperature of fluids forming the travertines. Distal from the source field of the hydrothermal fluids, paper-thin raft type facies were developed in shallow pools. Proximal to the source field of the hydrothermal fluids, crystalline crust facies and coated bubble facies were deposited. Existence of breccia facies indicates the effects of active tectonism during the formation of travertines. Hot hydrothermal pools on the ridge type travertines prove the still active tectonic activities. On-going studies aim to date growth of the travertines by U-Th dating method which will also shed some light on the tectonic scenario behind the evolution of the travertines.

After the withdrawal of 'informed choice': the meanings and social effects of mothers' choice for HIV prevention in Senegal.

PubMed

Desclaux, Alice

2014-01-01

To prevent HIV transmission through breastfeeding, African health services in 1998 implemented the World Health Organization's approach of 'informed choice' when recommending infant feeding options to HIV-positive mothers. In 2010, 'informed choice' was withdrawn in favour of antiretroviral prophylaxis with breastfeeding. A 2010-11 ethnographic study conducted in Senegal among HIV-positive mothers revealed three broad responses to the withdrawal of choice and formula provision: 'resistance' from association members claiming the health system was responsible for providing formula to ensure efficient prevention; 'compliance' among mothers adopting 'protected breastfeeding' without complaints; and 'self-reliance' among women trying to obtain formula through other means without mentioning choice. These three responses shed light on the meanings attributed to choice and on the social impact of formula provision during the 'informed choice era.' The analysis shows that the top-down introduction of 'informed choice' as an ethical and management imperative was appropriated and re-signified locally, making space for new forms of sociality within medical and associative social spaces. These social forms could not easily be maintained after the withdrawal of formula provision; women who continue to exert choice do so silently. By focusing on the upheaval of social care arrangements after the introduction of prophylaxis by pharmaceuticals, this paper sheds light on the understudied local consequences of changes in public health policies and the social framing of 'choice' in low-income countries' health systems.

Shedding Light on the Battlefield: Tactical Applications of Photonic Technology

DTIC Science & Technology

2004-11-01

of the first applications of photonics to communications was the photophone ,1 demonstrated by Alexander Graham Bell in 1880, which used light beams to...transmit information wirelessly. Bell believed the invention of the photophone was more significant than that of the telephone, but it took almost... photophone used sunlight and vibrating mirrors to transmit the human voice. http://inventors.about.com/library/inventors/bltelephone3.htm, accessed April

Teaching: In Light of Noel Gough's and Ajay Sharma's Articles

ERIC Educational Resources Information Center

Pouliot, Chantal

2017-01-01

In their articles, Ajay Sharma (Cult Stud Sci Educ, doi:10.1007/s11422-017-9835-z, 2017) and Noel Gough (Cult Stud Sci Educ, doi:10.1007/s11422-017-9834-0, 2017) shed light on the impact neoliberalism has on the teaching of science and suggest ways to ensure that science education remains critical and socially equitable. In this paper, I…

A dynamical systems analysis of the kinematics of time-periodic vortex shedding past a circular cylinder

NASA Technical Reports Server (NTRS)

Ottino, Julio M.

1991-01-01

Computer flow simulation aided by dynamical systems analysis is used to investigate the kinematics of time-periodic vortex shedding past a two-dimensional circular cylinder in the context of the following general questions: (1) Is a dynamical systems viewpoint useful in the understanding of this and similar problems involving time-periodic shedding behind bluff bodies; and (2) Is it indeed possible, by adopting such a point of view, to complement previous analyses or to understand kinematical aspects of the vortex shedding process that somehow remained hidden in previous approaches. We argue that the answers to these questions are positive. Results are described.

NEOS Data and the Origin of the 5 MeV Bump in the Reactor Antineutrino Spectrum

NASA Astrophysics Data System (ADS)

Huber, Patrick

2017-01-01

We perform a combined analysis of recent NEOS and Daya Bay data on the reactor antineutrino spectrum. This analysis includes approximately 1.5 million antineutrino events, which is the largest neutrino event sample analyzed to date. We use a double ratio which cancels flux model dependence and related uncertainties as well as the effects of the detector response model. We find at 3-4 standard deviation significance level, that plutonium-239 and plutonium-241 are disfavored as the single source for the so-called 5 MeV bump. This analysis method has general applicability and, in particular, with higher statistics data sets, will be able to shed significant light on the issue of the bump. With some caveats, this should also allow us to improve the sensitivity for sterile neutrino searches in NEOS.

[Freud in Carinthia. A historical search].

PubMed

Oberlerchner, Herwig; Tögel, Christfried

2015-01-01

This paper sheds some new light on four visits of Freud to Carinthia between 1898 and 1923. New information from contemporary sources is added to already known facts (patient visit in 1898; encounters with Alban Berg in 1900 and 1907).

Seventy Five Years of Particle Accelerators (LBNL Summer Lecture Series)

ScienceCinema

Sessler, Andy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2017-12-09

Summer Lecture Series 2006: Andy Sessler, Berkeley Lab director from 1973 to 1980, sheds light on the Lab's nearly eight-decade history of inventing and refining particle accelerators, which continue to illuminate the nature of the universe.

Seventy Five Years of Particle Accelerators

ScienceCinema

Sessler, Andy

2017-12-09

Andy Sessler, Berkeley Lab director from 1973 to 1980, sheds light on the Lab's nearly eight-decade history of inventing and refining particle accelerators, which continue to illuminate the nature of the universe. His talk was presented July 26, 2006.

Experiments shed new light on nickel-fluorine reactions

NASA Technical Reports Server (NTRS)

Fischer, J.; Gunther, W.; Jarry, R. L.

1967-01-01

Isotopic tracer experiments and scale-impingement experiments show fluorine to be the migrating species through the nickel fluoride scale formed during the fluorination of nickel. This is in contrast to nickel oxide scales, where nickel is the migrating species.

A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism

PubMed Central

Douam, Florian; Mancip, Jimmy; Mailly, Laurent; Montserret, Roland; Ding, Qiang; Verhoeyen, Els; Baumert, Thomas F.; Ploss, Alexander; Carbone, Alessandra

2018-01-01

Amino-acid coevolution can be referred to mutational compensatory patterns preserving the function of a protein. Viral envelope glycoproteins, which mediate entry of enveloped viruses into their host cells, are shaped by coevolution signals that confer to viruses the plasticity to evade neutralizing antibodies without altering viral entry mechanisms. The functions and structures of the two envelope glycoproteins of the Hepatitis C Virus (HCV), E1 and E2, are poorly described. Especially, how these two proteins mediate the HCV fusion process between the viral and the cell membrane remains elusive. Here, as a proof of concept, we aimed to take advantage of an original coevolution method recently developed to shed light on the HCV fusion mechanism. When first applied to the well-characterized Dengue Virus (DENV) envelope glycoproteins, coevolution analysis was able to predict important structural features and rearrangements of these viral protein complexes. When applied to HCV E1E2, computational coevolution analysis predicted that E1 and E2 refold interdependently during fusion through rearrangements of the E2 Back Layer (BL). Consistently, a soluble BL-derived polypeptide inhibited HCV infection of hepatoma cell lines, primary human hepatocytes and humanized liver mice. We showed that this polypeptide specifically inhibited HCV fusogenic rearrangements, hence supporting the critical role of this domain during HCV fusion. By combining coevolution analysis and in vitro assays, we also uncovered functionally-significant coevolving signals between E1 and E2 BL/Stem regions that govern HCV fusion, demonstrating the accuracy of our coevolution predictions. Altogether, our work shed light on important structural features of the HCV fusion mechanism and contributes to advance our functional understanding of this process. This study also provides an important proof of concept that coevolution can be employed to explore viral protein mediated-processes, and can guide the development of innovative translational strategies against challenging human-tropic viruses. PMID:29505618

Morphological reconstruction of Roman arrowheads from Iulia Concordia: Italy

NASA Astrophysics Data System (ADS)

Salvemini, Filomena; Grazzi, Francesco; Angelini, Ivana; Vontobel, Peter; Vigoni, Alberto; Artioli, Gilberto; Zoppi, Marco

2014-06-01

Iulia Concordia is an important Roman settlement especially known for the production of weapons during the Roman Empire. Excavations of the area revealed the evidence of metal-working activities and a huge number of well preserved arrowheads (sagittae) were found. In order to investigate the conservation state of the finds and to shed light about the production processes used by Roman for the manufacturing of sagittae, a neutron tomography analysis was performed on NEUTRA beam line at the Paul Scherrer Institut in Switzerland. Here, we present results from our investigation conducted on 18 samples, disclosing, in a non-invasive way, the morphological characteristic related to the ancient Roman working techniques.

State space approach to mixed boundary value problems.

NASA Technical Reports Server (NTRS)

Chen, C. F.; Chen, M. M.

1973-01-01

A state-space procedure for the formulation and solution of mixed boundary value problems is established. This procedure is a natural extension of the method used in initial value problems; however, certain special theorems and rules must be developed. The scope of the applications of the approach includes beam, arch, and axisymmetric shell problems in structural analysis, boundary layer problems in fluid mechanics, and eigenvalue problems for deformable bodies. Many classical methods in these fields developed by Holzer, Prohl, Myklestad, Thomson, Love-Meissner, and others can be either simplified or unified under new light shed by the state-variable approach. A beam problem is included as an illustration.

A long- and short-run analysis of electricity demand in Ciudad Juarez

NASA Astrophysics Data System (ADS)

Mendez-Carrillo, Ericka Cecilia

Economic growth and appliance saturation are increasing electricity consumption in Mexico. Annual frequency data from 1990 to 2012 are utilized to develop an error correction framework that sheds light on short- and long-run electricity consumption behavior in Ciudad Juarez, a large Mexican metropolitan economy at the border with the United States. The results for this study reveal that electricity is an inelastic normal good in this market. Moreover, natural gas is found to be a weak complement to electricity. With regards to the customer base in this urban economy, population, employment, and income exercise positive and statistically significant impacts on the demand for electricity hook-ups.

Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system

PubMed Central

Randall, Andrew D; Kurihara, Mai; Brandon, Nicholas J; Brown, Jon T

2014-01-01

The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS. PMID:24712987

The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites.

PubMed

Grzybek, Maciej; Golonko, Aleksandra; Górska, Aleksandra; Szczepaniak, Klaudiusz; Strachecka, Aneta; Lass, Anna; Lisowski, Paweł

2018-06-01

The CRISPR/Cas9 system, a natural defence system of bacterial organisms, has recently been used to modify genomes of the most important protozoa parasites. Successful genome manipulations with the CRISPR/Cas9 system are changing the present view of genetics in parasitology. The application of this system offers a major chance to overcome the current restriction in culturing, maintaining and analysing protozoan parasites, and allows dynamic analysis of parasite genes functions, leading to a better understanding of pathogenesis. CRISPR/Cas9 system will have a significant influence on the process of developing novel drugs and treatment strategies against protozoa parasites.

Power-law distribution in Japanese racetrack betting

NASA Astrophysics Data System (ADS)

Ichinomiya, Takashi

2006-08-01

Gambling is one of the basic economic activities that humans indulge in. An investigation of gambling activities provides deep insights into the economic actions of people and sheds lights on the study of econophysics. In this paper we present an analysis of the distribution of the final odds of the races organized by the Japan Racing Association. The distribution of the final odds Po(x) indicates a clear power-law Po(x)∝1/x, where x represents the final odds. This power-law can be explained on the basis of the assumption that every bettor bets his money on the horse that appears to be the strongest in a race.

Y chromosome evolution: emerging insights into processes of Y chromosome degeneration

PubMed Central

Bachtrog, Doris

2014-01-01

The human Y chromosome is intriguing not only because it harbours the master-switch gene determining gender but also because of its unusual evolutionary trajectory. Previously an autosome, Y chromosome evolution has been characterized by massive gene decay. Recent whole-genome and transcriptome analyses of Y chromosomes in humans and other primates, in Drosophila species as well as in plants have shed light on the current gene content of the Y, its origins and its long-term fate. Comparative analysis of young and old Y chromosomes have given further insights into the evolutionary and molecular forces triggering Y degeneration and its evolutionary destiny. PMID:23329112

Punctuated equilibrium dynamics in human communications

NASA Astrophysics Data System (ADS)

Peng, Dan; Han, Xiao-Pu; Wei, Zong-Wen; Wang, Bing-Hong

2015-10-01

A minimal model based on network incorporating individual interactions is proposed to study the non-Poisson statistical properties of human behavior: individuals in system interact with their neighbors, the probability of an individual acting correlates to its activity, and all the individuals involved in action will change their activities randomly. The model reproduces varieties of spatial-temporal patterns observed in empirical studies of human daily communications, providing insight into various human activities and embracing a range of realistic social interacting systems, particularly, intriguing bimodal phenomenon. This model bridges priority queueing theory and punctuated equilibrium dynamics, and our modeling and analysis is likely to shed light on non-Poisson phenomena in many complex systems.

Spectroscopic study of proflavine adsorption on the carbon nanotube surface.

PubMed

Buchelnikov, Anatoly S; Dovbeshko, Galina I; Voronin, Dmitry P; Trachevsky, Vladimir V; Kostjukov, Viktor V; Evstigneev, Maxim P

2014-01-01

Despite the fact that non-covalent interactions between various aromatic compounds and carbon nanotubes are being extensively investigated now, there is still a lack of understanding about the nature of such interactions. The present paper sheds light on one of the possible mechanisms of interaction between the typical aromatic dye proflavine and the carbon nanotube surface, namely, π-stacking between aromatic rings of these compounds. To investigate such a complexation, a qualitative analysis was performed by means of ultraviolet visible, infrared, and nuclear magnetic resonance spectroscopy. The data obtained suggest that π-stacking brings the major contribution to the stabilization of the complex between proflavine and the carbon nanotube.

An Agent-Based Model of Centralized Institutions, Social Network Technology, and Revolution

PubMed Central

Makowsky, Michael D.; Rubin, Jared

2013-01-01

This paper sheds light on the general mechanisms underlying large-scale social and institutional change. We employ an agent-based model to test the impact of authority centralization and social network technology on preference falsification and institutional change. We find that preference falsification is increasing with centralization and decreasing with social network range. This leads to greater cascades of preference revelation and thus more institutional change in highly centralized societies and this effect is exacerbated at greater social network ranges. An empirical analysis confirms the connections that we find between institutional centralization, social radius, preference falsification, and institutional change. PMID:24278280

Meaning making after a near-death experience: The relevance of intrapsychic and interpersonal dynamics.

PubMed

Bianco, Simone; Sambin, Marco; Palmieri, Arianna

2017-10-01

This study aims to investigate the processes used by individuals to integrate a near-death experience (NDE) and to discuss the use of a meaning-making component to help people who have had such experiences. A psychotherapist interviewed six individuals who reported having had a NDE. Transcripts of the interviews were coded using an interpretative phenomenological analysis. The authors identified intrapsychic and interpersonal dynamics implicated in the individuals' meaning-making processes, and the problems encountered during their integration of the experience. Meaning-based approaches are a feasible theoretical framework for shedding light on the NDE and providing support for people who have lived through them.

Human Lice in Paleoentomology and Paleomicrobiology.

PubMed

Drali, Rezak; Mumcuoglu, Kosta; Raoult, Didier

2016-08-01

Lice are a classic example of cospeciation. Human lice confirm this cospeciation with lice specialized in hominids which differ from those of gorillas and chimpanzees. Head lice and body lice seem to belong to closely related species with different ecotypes and a different geographical distribution which may reflect population movements. Paleo-entomology allows us in some cases to trace the migrations of archaic human populations. The analysis of lice found on mummies in Egypt and South America has clarified a certain number of these migrations, also the study of lice and the diseases they transmit has shed a new light on the epidemics of the past.

SUMER-IRIS Observations of AR11875

NASA Astrophysics Data System (ADS)

Schmit, Donald; Innes, Davina

2014-05-01

We present results of the first joint observing campaign of IRIS and SOHO/SUMER. While the IRIS datasets provide information on the chromosphere and transition region, SUMER provides complementary diagnostics on the corona. On 2013-10-24, we observed an active region, AR11875, and the surrounding plage for approximately 4 hours using rapid-cadence observing programs. These datasets include spectra from a small C -class flare which occurs in conjunction with an Ellerman-bomb type event. Our analysis focusses on how the high spatial resolution and slit jaw imaging capabilities of IRIS shed light on the unresolved structure of transient events in the SUMER catalog.

Investigating Student Communities with Network Analysis of Interactions in a Physics Learning Center

NASA Astrophysics Data System (ADS)

Brewe, Eric; Kramer, Laird; O'Brien, George

2009-11-01

We describe our initial efforts at implementing social network analysis to visualize and quantify student interactions in Florida International University's Physics Learning Center. Developing a sense of community among students is one of the three pillars of an overall reform effort to increase participation in physics, and the sciences more broadly, at FIU. Our implementation of a research and learning community, embedded within a course reform effort, has led to increased recruitment and retention of physics majors. Finn and Rock [1997] link the academic and social integration of students to increased rates of retention. To identify these interactions, we have initiated an investigation that utilizes social network analysis to identify primary community participants. Community interactions are then characterized through the network's density and connectivity, shedding light on learning communities and participation. Preliminary results, further research questions, and future directions utilizing social network analysis are presented.

Analysis of Autopilot Behavior

NASA Technical Reports Server (NTRS)

Sherry, Lance; Polson, Peter; Feay, Mike; Palmer, Everett; Null, Cynthia H. (Technical Monitor)

1998-01-01

Aviation and cognitive science researchers have identified situations in which the pilot's expectations for behavior of autopilot avionics are not matched by the actual behavior of the avionics. These "automation surprises" have been attributed to differences between the pilot's model of the behavior of the avionics and the actual behavior encoded in the avionics software. A formal technique is described for the analysis and measurement of the behavior of the cruise pitch modes of a modern Autopilot. The analysis characterizes the behavior of the Autopilot as situation-action rules. The behavior of the cruise pitch mode logic for a contemporary modern Autopilot was found to include 177 rules, including Level Change (23), Vertical Speed (16), Altitude Capture (50), and Altitude Hold (88). These rules are determined based on the values of 62 inputs. Analysis of the rule-based model also shed light on the factors cited in the literature as contributors to "automation surprises."

Evolution of Daily Gene Co-expression Patterns from Algae to Plants

PubMed Central

de los Reyes, Pedro; Romero-Campero, Francisco J.; Ruiz, M. Teresa; Romero, José M.; Valverde, Federico

2017-01-01

Daily rhythms play a key role in transcriptome regulation in plants and microalgae orchestrating responses that, among other processes, anticipate light transitions that are essential for their metabolism and development. The recent accumulation of genome-wide transcriptomic data generated under alternating light:dark periods from plants and microalgae has made possible integrative and comparative analysis that could contribute to shed light on the evolution of daily rhythms in the green lineage. In this work, RNA-seq and microarray data generated over 24 h periods in different light regimes from the eudicot Arabidopsis thaliana and the microalgae Chlamydomonas reinhardtii and Ostreococcus tauri have been integrated and analyzed using gene co-expression networks. This analysis revealed a reduction in the size of the daily rhythmic transcriptome from around 90% in Ostreococcus, being heavily influenced by light transitions, to around 40% in Arabidopsis, where a certain independence from light transitions can be observed. A novel Multiple Bidirectional Best Hit (MBBH) algorithm was applied to associate single genes with a family of potential orthologues from evolutionary distant species. Gene duplication, amplification and divergence of rhythmic expression profiles seems to have played a central role in the evolution of gene families in the green lineage such as Pseudo Response Regulators (PRRs), CONSTANS-Likes (COLs), and DNA-binding with One Finger (DOFs). Gene clustering and functional enrichment have been used to identify groups of genes with similar rhythmic gene expression patterns. The comparison of gene clusters between species based on potential orthologous relationships has unveiled a low to moderate level of conservation of daily rhythmic expression patterns. However, a strikingly high conservation was found for the gene clusters exhibiting their highest and/or lowest expression value during the light transitions. PMID:28751903

Shedding (Incoherent) Light on Quantum Effects in Light-Induced Biological Processes.

PubMed

Brumer, Paul

2018-05-18

Light-induced processes that occur in nature, such as photosynthesis and photoisomerization in the first steps in vision, are often studied in the laboratory using coherent pulsed laser sources, which induce time-dependent coherent wavepacket molecule dynamics. Nature, however, uses stationary incoherent thermal radiation, such as sunlight, leading to a totally different molecular response, the time-independent steady state. It is vital to appreciate this difference in order to assess the role of quantum coherence effects in biological systems. Developments in this area are discussed in detail.

Axial-Current Matrix Elements in Light Nuclei from Lattice QCD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Savage, Martin; Shanahan, Phiala E.; Tiburzi, Brian C.

2016-12-01

I present results from the first lattice QCD calculations of axial-current matrix elements in light nuclei, performed by the NPLQCD collaboration. Precision calculations of these matrix elements, and the subsequent extraction of multi-nucleon axial-current operators, are essential in refining theoretical predictions of the proton-proton fusion cross section, neutrino-nucleus cross sections andmore » $$\\beta\\beta$$-decay rates of nuclei. In addition, they are expected to shed light on the phenomenological quenching of $$g_A$$ that is required in nuclear many-body calculations.« less

Design of multisegmented freeform lens for LED fishing/working lamp with high efficiency.

PubMed

Lai, Min-Feng; Anh, Nguyen Doan Quoc; Gao, Jia-Zhi; Ma, Hsin-Yi; Lee, Hsiao-Yi

2015-10-01

A novel LED fishing/working light is proposed to enhance the lighting efficiency of a fishing boat. The study is focused on the freeform secondary lens design so as to create a lamp that attracts fish and sheds light on the deck for the crew's work. The experimental results show that the proposed multisegmented freeform lens can deliver the proposed aim, giving 3 times as much illuminating power as the traditional high-intensity discharge fishing lamp does with the same input of electrical power.

Replication, pathogenicity, shedding, and transmission of Zaire ebolavirus in pigs.

PubMed

Kobinger, Gary P; Leung, Anders; Neufeld, James; Richardson, Jason S; Falzarano, Darryl; Smith, Greg; Tierney, Kevin; Patel, Ami; Weingartl, Hana M

2011-07-15

(See the editorial commentary by Bausch, on pages 179-81.) Reston ebolavirus was recently detected in pigs in the Philippines. Specific antibodies were found in pig farmers, indicating exposure to the virus. This important observation raises the possibility that pigs may be susceptible to Ebola virus infection, including from other species, such as Zaire ebolavirus (ZEBOV), and can transmit to other susceptible hosts. This study investigated whether ZEBOV, a species commonly reemerging in central Africa, can replicate and induce disease in pigs and can be transmitted to naive animals. Domesticated Landrace pigs were challenged through mucosal exposure with a total of 1 ×10(6) plaque-forming units of ZEBOV and monitored for virus replication, shedding, and pathogenesis. Using similar conditions, virus transmission from infected to naive animals was evaluated in a second set of pigs. Following mucosal exposure, pigs replicated ZEBOV to high titers (reaching 10(7) median tissue culture infective doses/mL), mainly in the respiratory tract, and developed severe lung pathology. Shedding from the oronasal mucosa was detected for up to 14 days after infection, and transmission was confirmed in all naive pigs cohabiting with inoculated animals. These results shed light on the susceptibility of pigs to ZEBOV infection and identify an unexpected site of virus amplification and shedding linked to transmission of infectious virus.

A Technique for Analysing Constrained Rigid-Body Systems, and Its Application to the Constraint Force Algorithm

NASA Technical Reports Server (NTRS)

Fijany, A.; Featherstone, R.

1999-01-01

This paper presents a new formulation of the Constraint Force Algorithm that corrects a major limitation in the original, and sheds new light on the relationship between it and other dynamics algoritms.

New Results on Io's Color and Composition

NASA Technical Reports Server (NTRS)

Geissler, P.; McEwen, A. S.; Phillips, C.; Keszthelyi, L.; Turtle, E.; Milazzo, M.; Lopes-Gautier, R.; Simonelli, D.; Williams, D.

2000-01-01

Galileo's recent high-resolution imaging provides new insights into the nature of Io's colorful surface, shedding light on the composition and origin of pyroclastic deposits and suggesting that Io's mysterious green spots are due to coating or alteration of silicate lavas.

Japanese Patterns of Behavior.

ERIC Educational Resources Information Center

Lebra, Takie Sugiyama

This book attempts to shed light on the seemingly contradictory aspects of Japanese behavior. Separate chapters, grounded in interaction-oriented social scientific theory, focus on the themes of social relativism, belongingness, empathy, dependency, occupying the proper place, reciprocity, situational interaction, early socialization, selfhood,…

Topography and Roughness Signatures of Erosion of Crusted Soils on Mars

NASA Astrophysics Data System (ADS)

Cooper, C. D.; Mustard, J. F.

1999-03-01

MOLA slope and roughness data shed light on the erosion of regional duricrust and suggest it follows preexisting topography. This implies that cementation of the duricrust was likely due to atmosphere-surface interactions or in situ alteration.

Interpretive phenomenological analysis of a lawsuit contending that school-based yoga is religion: A study of school personnel.

PubMed

Cook-Cottone, Catherine; Lemish, Erga; Guyker, Wendy

2017-11-01

This study focused on the perspectives of school personnel affiliated with the Encinitas Union School District in California following a lawsuit arguing that their yoga-based program included religion and therefore was unsuitable for implementation in public schools and was unconstitutional. Participants (N = 32) were interviewed using a semistructured interview, and data were analyzed according to Interpretative Phenomenological Analysis. Five super-ordinate themes (including sub-themes) were identified in an iterative process, including: participants' perspectives on the roots of yoga and the type of yoga taught in their district; the process of introducing a yoga-in-the-schools program in light of this contention (including challenges and obstacles, and how these were met); perspectives on the lawsuit and how the process unfolded; effects of the lawsuit on school climate and beyond; and perspectives on yoga as, and as not, religious. The study attempts to shed light on the impact of an ongoing lawsuit on a school district at the time of implementation of a program for students' well being.

Interpretive phenomenological analysis of a lawsuit contending that school-based yoga is religion: A study of school personnel.

PubMed

Cook-Cottone, Catherine; Lemish, Erga; Guyker, Wendy

2017-08-01

This study focused on the perspectives of school personnel affiliated with the Encinitas Union School District in California following a lawsuit arguing that their yoga-based program included religion and therefore was unsuitable for implementation in public schools and was unconstitutional. Participants (N = 32) were interviewed using a semistructured interview, and data were analyzed according to Interpretative Phenomenological Analysis. Five super-ordinate themes (including sub-themes) were identified in an iterative process, including: participants' perspectives on the roots of yoga and the type of yoga taught in their district; the process of introducing a yoga-in-the-schools program in light of this contention (including challenges and obstacles, and how these were met); perspectives on the lawsuit and how the process unfolded; effects of the lawsuit on school climate and beyond; and perspectives on yoga as, and as not, religious. The study attempts to shed light on the impact of an ongoing lawsuit on a school district at the time of implementation of a program for students' well being.

Suspended-Sediment Impacts on Light-limited Productivity in the Delaware Estuary

NASA Astrophysics Data System (ADS)

McSweeney, J.; Chant, R. J.; Wilkin, J.; Sommerfield, C. K.

2016-12-01

The Delaware Estuary has a history of high anthropogenic nutrient loadings, but has been classified as a high-nutrient, low-growth system due persistent light limitations caused by turbidity. While the biogeochemical implications of light limitation in turbid estuaries has been well-studied, there has been minimal effort focused on the connectivity between hydrodynamics, sediment dynamics, and light-limitation. Our understanding of sediment dynamics in the Delaware Estuary has advanced significantly in the last decade, and this study provides insight about how the spatiotemporal variability of the estuarine turbidity maximum controls the light available for primary productivity. This analysis uses data from eight along-estuary cruises from March, June, September, and December 2010 and 2011 to look at the seasonality of suspended sediment and chlorophyll distributions. By estimating the absorption due to sediment under a range of environmental conditions, we describe how the movement of the turbidity maximum affects light availability. We also use an idealized 2-dimensional Regional Ocean Modeling System (ROMS) numerical model to evaluate how river discharge and spring-neap variability modulate the location of phytoplankton blooms. We conclude that high river flows and neap tides can drive stratification that is strong enough to prevent sediment from being resuspended into the surface layer, thus providing light conditions favorable for primary productivity. This study sheds light on the importance of sediment in the limiting primary productivity, and the role of stratification in promoting production, highlighting the potential limitations of biogeochemical models that do not account for sediment absorption.

Genetic analysis of the cytoplasmic dynein subunit families.

PubMed

Pfister, K Kevin; Shah, Paresh R; Hummerich, Holger; Russ, Andreas; Cotton, James; Annuar, Azlina Ahmad; King, Stephen M; Fisher, Elizabeth M C

2006-01-01

Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of the subunits are encoded by at least two genes. Here we review current knowledge concerning the subunits, their interactions, and their functional roles as derived from biochemical and genetic analyses. We also carried out extensive database searches to look for new genes and to clarify anomalies in the databases. Our analysis documents evolutionary relationships among the dynein subunits of mammals and other model organisms, and sheds new light on the role of this diverse group of proteins, highlighting the existence of two cytoplasmic dynein complexes with distinct cellular roles.

Genetic Analysis of the Cytoplasmic Dynein Subunit Families

PubMed Central

Pfister, K. Kevin; Shah, Paresh R; Hummerich, Holger; Russ, Andreas; Cotton, James; Annuar, Azlina Ahmad; King, Stephen M; Fisher, Elizabeth M. C

2006-01-01

Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of the subunits are encoded by at least two genes. Here we review current knowledge concerning the subunits, their interactions, and their functional roles as derived from biochemical and genetic analyses. We also carried out extensive database searches to look for new genes and to clarify anomalies in the databases. Our analysis documents evolutionary relationships among the dynein subunits of mammals and other model organisms, and sheds new light on the role of this diverse group of proteins, highlighting the existence of two cytoplasmic dynein complexes with distinct cellular roles. PMID:16440056

Trends in hospital efficiency among metropolitan markets.

PubMed

Wang, B B; Ozcan, Y A; Wan, T T; Harrison, J

1999-04-01

This study evaluates trends in efficiency among American hospital markets. A total of 6010 hospitals were identified for use in the analysis from the American Hospital Association's Annual Surveys for 1989 and 1993. Using data envelopment analysis (DEA), a longitudinal study of hospital efficiency was conducted on all 314 metropolitan markets in the United States. Results suggest that large hospital markets generally demonstrated higher inefficiency. The major inefficiencies exist in the availability of hospital services, the number of operating beds, the utilization of hospital staffing and operating expenses. Consequently, the large hospital market had a significant excess of health manpower that resulted in inefficiency that amounted to approximately $23 billion. From a policy perspective, this study has shed some light on the need to establish more specific policies to address inefficiency in the health care industry.

Docking studies on NSAID/COX-2 isozyme complexes using Contact Statistics analysis

NASA Astrophysics Data System (ADS)

Ermondi, Giuseppe; Caron, Giulia; Lawrence, Raelene; Longo, Dario

2004-11-01

The selective inhibition of COX-2 isozymes should lead to a new generation of NSAIDs with significantly reduced side effects; e.g. celecoxib (Celebrex®) and rofecoxib (Vioxx®). To obtain inhibitors with higher selectivity it has become essential to gain additional insight into the details of the interactions between COX isozymes and NSAIDs. Although X-ray structures of COX-2 complexed with a small number of ligands are available, experimental data are missing for two well-known selective COX-2 inhibitors (rofecoxib and nimesulide) and docking results reported are controversial. We use a combination of a traditional docking procedure with a new computational tool (Contact Statistics analysis) that identifies the best orientation among a number of solutions to shed some light on this topic.

A Combination of Histological, Physiological, and Proteomic Approaches Shed Light on Seed Desiccation Tolerance of the Basal Angiosperm Amborella trichopoda.

PubMed

Villegente, Matthieu; Marmey, Philippe; Job, Claudette; Galland, Marc; Cueff, Gwendal; Godin, Béatrice; Rajjou, Loïc; Balliau, Thierry; Zivy, Michel; Fogliani, Bruno; Sarramegna-Burtet, Valérie; Job, Dominique

2017-07-28

Desiccation tolerance allows plant seeds to remain viable in a dry state for years and even centuries. To reveal potential evolutionary processes of this trait, we have conducted a shotgun proteomic analysis of isolated embryo and endosperm from mature seeds of Amborella trichopoda , an understory shrub endemic to New Caledonia that is considered to be the basal extant angiosperm. The present analysis led to the characterization of 415 and 69 proteins from the isolated embryo and endosperm tissues, respectively. The role of these proteins is discussed in terms of protein evolution and physiological properties of the rudimentary, underdeveloped, Amborella embryos, notably considering that the acquisition of desiccation tolerance corresponds to the final developmental stage of mature seeds possessing large embryos.

A Combination of Histological, Physiological, and Proteomic Approaches Shed Light on Seed Desiccation Tolerance of the Basal Angiosperm Amborella trichopoda

PubMed Central

Villegente, Matthieu; Marmey, Philippe; Job, Claudette; Galland, Marc; Cueff, Gwendal; Godin, Béatrice; Rajjou, Loïc; Balliau, Thierry; Zivy, Michel; Sarramegna-Burtet, Valérie; Job, Dominique

2017-01-01

Desiccation tolerance allows plant seeds to remain viable in a dry state for years and even centuries. To reveal potential evolutionary processes of this trait, we have conducted a shotgun proteomic analysis of isolated embryo and endosperm from mature seeds of Amborella trichopoda, an understory shrub endemic to New Caledonia that is considered to be the basal extant angiosperm. The present analysis led to the characterization of 415 and 69 proteins from the isolated embryo and endosperm tissues, respectively. The role of these proteins is discussed in terms of protein evolution and physiological properties of the rudimentary, underdeveloped, Amborella embryos, notably considering that the acquisition of desiccation tolerance corresponds to the final developmental stage of mature seeds possessing large embryos. PMID:28788068

Optimizing resource allocation and patient flow: process analysis and reorganization in three chemotherapy outpatient clinics.

PubMed

Holmes, Morgan; Bodie, Kelly; Porter, Geoffrey; Sullivan, Victoria; Tarasuk, Joy; Trembley, Jodie; Trudeau, Maureen

2010-01-01

Optimizing human and physical resources is a major concern for cancer care decision-makers and practitioners. This issue is particularly acute in the context of ambulatory out patient chemotherapy clinics, especially when - as is the case almost everywhere in the industrialized world - the number of people requiring systemic therapy is increasing while budgets, staffing and physical space remain static. Recent initiatives at three hospital-based chemotherapy units - in Halifax, Toronto and Kingston - shed light on the value of process analysis and reorganization for using existing human and physical resources to their full potential, improving patient flow and enhancing patient satisfaction. The steps taken in these settings are broadly applicable to other healthcare settings and would likely result in similar benefits in those environments.

A systematic review and meta-analysis of phase I inactivated vaccines to reduce shedding of Coxiella burnetii from sheep and goats from routes of public health importance.

PubMed

O'Neill, T J; Sargeant, J M; Poljak, Z

2014-12-01

Q fever in humans and coxiellosis in livestock are both caused by Coxiella burnetii. The public health importance of vaccination against C. burnetii shedding from sheep and goats was evaluated using systematic review and meta-analysis to provide evidence for policy direction to prevent potential zoonotic spread. Publications reporting shedding of C. burnetii in vaginal and uterine secretions, milk, placenta and faeces were included. A single observational (one goat) and seven experimental (four goat and three sheep) vaccine studies were included in the review. No relevant publications on other interventions were identified. Random effects meta-analyses were performed for the risk of shedding in individuals in the control and vaccinated groups and for the mean difference in the level of bacterial shedding in sheep and goats stratified by age and previous exposure status. Limited data were available for further analytic evaluation. From the pooled analysis, an inactivated phase I vaccine significantly reduced the risk of shedding from uterine (RR = 0.10; 95%CI 0.05-0.20) secretions in previously sensitized goats. Individual studies reported significant risk reduction in milk (RR = 0.03; 95%CI 0.01-0.26), vaginal secretions (RR = 0.40; 95%CI 0.22-0.75) and faeces (RR = 0.79; 95%CI 0.63-0.97) from naïve goats. The pooled mean levels of bacteria shed from placental [mean difference (MD = -5.24 Log10 ; 95%CI -6.75 to -3.7)] and vaginal (MD = -1.78 Log10 ; 95%CI -2.19 to -1.38) routes were significantly decreased in vaccinated naïve goats compared with controls. Shedding through all other routes from vaccinated goats was not significantly different than shedding from control goats. No effect of vaccination was found on the risk of shedding or the mean level of shedding in vaccinated sheep compared with control sheep. Our conclusions are based on a limited amount of data with variable risk of systematic error. © 2013 Blackwell Verlag GmbH.

Light composite scalar in twelve-flavor QCD on the lattice.

PubMed

Aoki, Yasumichi; Aoyama, Tatsumi; Kurachi, Masafumi; Maskawa, Toshihide; Nagai, Kei-ichi; Ohki, Hiroshi; Rinaldi, Enrico; Shibata, Akihiro; Yamawaki, Koichi; Yamazaki, Takeshi

2013-10-18

On the basis of lattice simulations using highly improved staggered quarks for twelve-flavor QCD with several bare fermion masses, we observe a flavor-singlet scalar state lighter than the pion in the correlators of fermionic interpolating operators. The same state is also investigated using correlators of gluonic interpolating operators. Combined with our previous study that showed twelve-flavor QCD to be consistent with being in the conformal window, we infer that the lightness of the scalar state is due to infrared conformality. This result shed some light on the possibility of a light composite Higgs boson ("technidilaton") in walking technicolor theories.

Leaf-on canopy closure in broadleaf deciduous forests predicted during winter

USGS Publications Warehouse

Twedt, Daniel J.; Ayala, Andrea J.; Shickel, Madeline R.

2015-01-01

Forest canopy influences light transmittance, which in turn affects tree regeneration and survival, thereby having an impact on forest composition and habitat conditions for wildlife. Because leaf area is the primary impediment to light penetration, quantitative estimates of canopy closure are normally made during summer. Studies of forest structure and wildlife habitat that occur during winter, when deciduous trees have shed their leaves, may inaccurately estimate canopy closure. We estimated percent canopy closure during both summer (leaf-on) and winter (leaf-off) in broadleaf deciduous forests in Mississippi and Louisiana using gap light analysis of hemispherical photographs that were obtained during repeat visits to the same locations within bottomland and mesic upland hardwood forests and hardwood plantation forests. We used mixed-model linear regression to predict leaf-on canopy closure from measurements of leaf-off canopy closure, basal area, stem density, and tree height. Competing predictive models all included leaf-off canopy closure (relative importance = 0.93), whereas basal area and stem density, more traditional predictors of canopy closure, had relative model importance of ≤ 0.51.

Land-based lidar mapping: a new surveying technique to shed light on rapid topographic change

USGS Publications Warehouse

Collins, Brian D.; Kayen, Robert

2006-01-01

The rate of natural change in such dynamic environments as rivers and coastlines can sometimes overwhelm the monitoring capacity of conventional surveying methods. In response to this limitation, U.S. Geological Survey (USGS) scientists are pioneering new applications of light detection and ranging (lidar), a laser-based scanning technology that promises to greatly increase our ability to track rapid topographic changes and manage their impact on affected communities.

A Comparative Proteome Approach Reveals Metabolic Changes Associated with Flammulina velutipes Mycelia in Response to Cold and Light Stress.

PubMed

Liu, Jing-Yu; Chang, Ming-Chang; Meng, Jun-Long; Feng, Cui-Ping; Wang, Yu

2018-04-11

In some industrial processes, cold and light stresses are recognized as two important environmental triggers for the transformation of mycelia into fruit-bodies via intermediate primordia in Flammulina velutipes cultivation. To gain insights into the mechanism of regulation of F. velutipes mycelia in response to cold and light stress, proteins expressed abundantly and characteristically at particular stress states were investigated by using the isobaric tags for the relative and absolute quantitation labeling technique. Among the 1046 nonredundant proteins identified with a high degree of confidence, 264 proteins, which were detected as differentially expressed proteins, were associated with 176 specific KEGG pathways. In-depth data analysis revealed that the regulatory network underlying the cold and light response mechanisms of F. velutipes mycelia was complex and multifaceted, as it included varied functions such as rapid energy supply, the biosynthesis of lysine, phenylalanine, tyrosine, and γ-aminobutyric acid, the calcium signal transduction process, dynein-dependent actin and microtubule cytoskeleton formation, autolysis, oxidative stress adaptation, pigment secretion, tissue and organ morphogenesis, and other interesting stress-related processes. Insights into the proteins might shed light on an intuitive understanding of the cold and light stress response mechanism underlying the fruiting processes of F. velutipes. Furthermore, the data might also provide further insights into the stress response mechanism of macro-fungi and valuable information for scientific improvement of some mushroom cultivation techniques in practice.

Measuring concentrations of selected air pollutants inside California vehicles : final report

DOT National Transportation Integrated Search

1998-12-01

This study provided the data needed to characterize in-transit exposures to air pollutants for California drivers. It also demonstrated a number of in-situ monitoring techniques in moving vehicles and provided findings that shed new light on particle...

Climate policy: Uncovering ocean-related priorities

NASA Astrophysics Data System (ADS)

Barkemeyer, Ralf

2017-11-01

Given the complexity and multi-faceted nature of policy processes, national-level policy preferences are notoriously difficult to capture. Now, research applying an automated text mining approach helps to shed light on country-level differences and priorities in the context of marine climate issues.

An investigation of the effects of reading and writing text-based messages while driving.

DOT National Transportation Integrated Search

2012-08-01

Previous research, using driving simulation, crash data, and naturalistic methods, has begun to shed light on the dangers of texting while driving. Perhaps because of the dangers, no published work has experimentally investigated the dangers of texti...

Shedding Light on Synergistic Chemical Genetic Connections with Machine Learning.

PubMed

Ekins, Sean; Siqueira-Neto, Jair Lage

2015-12-23

Machine learning can be used to predict compounds acting synergistically, and this could greatly expand the universe of available potential treatments for diseases that are currently hidden in the dark chemical matter. Copyright © 2015 Elsevier Inc. All rights reserved.

SYNOPSIS OF EMERGING PATHOGEN WORKSHOP PUBLICATION

EPA Science Inventory

This presentation will highlight the core principles and findings from the 2001 workshop, the proceedings of which were recently published in a special edition of Compost Science. It will also provide a historical, policy and regulatory framework to shed light on, and be...

Magical thinking by inpatient staff members.

PubMed

Pilette, W L

1983-01-01

Magical thinking is a primitive form of mental activity which, nevertheless, the author contends, is common among mental health professionals. Four examples of magical thinking by inpatient staff members are presented and briefly explored, in order to shed light on our work and ourselves.

24. Photocopy of construction drawing (microfilm in NJ TRANSIT archive, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. Photocopy of construction drawing (microfilm in NJ TRANSIT archive, Newark, N.J., uncatalogued), Elevations & Sections, 1930. - Delaware, Lackawanna & Western Railroad Freight & Rail Yard, Multiple Unit Light Inspection Shed, New Jersey Transit Hoboken Terminal Rail Yard, Hoboken, Hudson County, NJ

25. Photocopy of construction drawing (microfilm in NJ TRANSIT archive, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. Photocopy of construction drawing (microfilm in NJ TRANSIT archive, Newark, N.J., uncatalogued), Floor Plan, 1930. - Delaware, Lackawanna & Western Railroad Freight & Rail Yard, Multiple Unit Light Inspection Shed, New Jersey Transit Hoboken Terminal Rail Yard, Hoboken, Hudson County, NJ

Monitoring visitor satisfaction: a comparison of comment cards and more in-depth surveys

Treesearch

Alan R. Graefe; James D. Absher; Robert C. Burns

2001-01-01

This paper compares responses to comment cards and more detailed on-site surveys at selected Corps of Engineers lakes. The results shed light on the validity, reliability, and usefulness of these alternative methods of monitoring customer satisfaction.

Bifidobacteria in Feces and Environmental Waters

EPA Science Inventory

Bifidobacteria have been recommended as potential indicators of human fecal pollution in surface waters even though very little is known about their presence in nonhuman fecal sources. The objective of this research was to shed light on the occurrence and molecular diversity of t...

Functional characterization of two concrete biofilms using pyrosequencing data

EPA Science Inventory

Phylogenetic studies of concrete biofilms using 16SrRNA-based approaches have demonstrated that concrete surfaces harbor a diverse microbial community. These approaches can provide information on the general taxonomical groups present in a sample but cannot shed light on the func...

Transverse Resonant Vibration of Non-Bearing Structures Caused by Wind

NASA Astrophysics Data System (ADS)

Jendzelovsky, Norbert; Antal, Roland

2017-10-01

Nowadays, there are increasing use of very thin, subtle and light structures in the field of building constructions. We can find such a structures as part of roofs or design facades. By using these lamellas like, non-bearing structures as a part of architectural design of buildings, it is necessary to consider wind effects on these structures. Subtle structures of this type are prone to vibration in the transverse direction of the wind flow. The fact that the vibration occurs depends on wind parameters (wind velocity, direction of an air flow) and it also depends on the properties of lamella (shape, length, mass, natural frequency, support type). The principal idea of this article is to show susceptibility of lamellae-like structures to transverse resonant vibration caused by the phenomenon called Von Karman effect. Comparison of susceptibility to transverse resonance vibration was analysed on the different shapes of lamellas loaded by different wind speed. Analysis was based on usage of empirically derived equations. Von Karman effect arise from wind flow past an object. Turbulence in the form of vortices are formed at the object and shed into the flowing stream intermittently. The potential problem is that this turbulence can induce vibrations into the lamella itself. In terms of this vibration problem, two frequencies are interesting. Von Karman shedding frequency is the frequency at which the vortices are formed and shed at the object. The vortex-shedding frequency increases with the velocity of the wind flow and decreases with the size of the object. Natural frequency of the object depends on the construction of the lamella itself. Parameters of lamella as a shape, mass, length, elasticity modulus of material and support types are directly involved in the calculation of natural frequency. Worst case scenario in the term of transverse resonant vibration occurs when the natural frequency of lamella is equal to the vortex-shedding frequency. In this case vibration rises and structure can be snapped or deformed permanently. In the long term vibration, fatigue stress can be significant. At the conclusion hazardous wind speed and recommendations for different shapes and parameters of lamellas are shown.

Proteins as sponges: a statistical journey along protein structure organization principles.

PubMed

Paola, Luisa Di; Paci, Paola; Santoni, Daniele; Ruvo, Micol De; Giuliani, Alessandro

2012-02-27

The analysis of a large database of protein structures by means of topological and shape indexes inspired by complex network and fractal analysis shed light on some organizational principles of proteins. Proteins appear much more similar to "fractal" sponges than to closely packed spheres, casting doubts on the tenability of the hydrophobic core concept. Principal component analysis highlighted three main order parameters shaping the protein universe: (1) "size", with the consequent generation of progressively less dense and more empty structures at an increasing number of residues, (2) "microscopic structuring", linked to the existence of a spectrum going from the prevalence of heterologous (different hydrophobicity) to the prevalence of homologous (similar hydrophobicity) contacts, and (3) "fractal shape", an organizing protein data set along a continuum going from approximately linear to very intermingled structures. Perhaps the time has come for seriously taking into consideration the real relevance of time-honored principles like the hydrophobic core and hydrophobic effect.

Characterization of ascaris from ecuador and zanzibar.

PubMed

Sparks, A M; Betson, M; Oviedo, G; Sandoval, C; Cooper, P J; Stothard, J R

2015-07-01

To shed light on the epidemiology of ascariasis in Ecuador and Zanzibar, 177 adult worms retrieved by chemo-expulsion from either people or pigs were collected, measured and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of the ribosomal internal transcribed spacer (ITS) region. Upon double digestion with RsaI and HaeIII, PCR-RFLP analysis revealed the presence of A. lumbricoides in people and A. suum in pigs in Ecuador. In contrast, while there are no pigs on Zanzibar, of the 56 worms obtained from people, one was genotyped as A. suum. No additional genetic variation was detected upon further PCR-RFLP analysis with several other restriction enzymes. Upon measurement, worm mass and length differed by location and by species, A. suum being lighter and longer. While there is no evidence to suggest zoonotic transmission in Ecuador, an enduring historical signature of previous zoonotic transmission remains on Zanzibar.

Multispot single-molecule FRET: High-throughput analysis of freely diffusing molecules

PubMed Central

Panzeri, Francesco

2017-01-01

We describe an 8-spot confocal setup for high-throughput smFRET assays and illustrate its performance with two characteristic experiments. First, measurements on a series of freely diffusing doubly-labeled dsDNA samples allow us to demonstrate that data acquired in multiple spots in parallel can be properly corrected and result in measured sample characteristics consistent with those obtained with a standard single-spot setup. We then take advantage of the higher throughput provided by parallel acquisition to address an outstanding question about the kinetics of the initial steps of bacterial RNA transcription. Our real-time kinetic analysis of promoter escape by bacterial RNA polymerase confirms results obtained by a more indirect route, shedding additional light on the initial steps of transcription. Finally, we discuss the advantages of our multispot setup, while pointing potential limitations of the current single laser excitation design, as well as analysis challenges and their solutions. PMID:28419142

Anatomy of scientific evolution.

PubMed

Yun, Jinhyuk; Kim, Pan-Jun; Jeong, Hawoong

2015-01-01

The quest for historically impactful science and technology provides invaluable insight into the innovation dynamics of human society, yet many studies are limited to qualitative and small-scale approaches. Here, we investigate scientific evolution through systematic analysis of a massive corpus of digitized English texts between 1800 and 2008. Our analysis reveals great predictability for long-prevailing scientific concepts based on the levels of their prior usage. Interestingly, once a threshold of early adoption rates is passed even slightly, scientific concepts can exhibit sudden leaps in their eventual lifetimes. We developed a mechanistic model to account for such results, indicating that slowly-but-commonly adopted science and technology surprisingly tend to have higher innate strength than fast-and-commonly adopted ones. The model prediction for disciplines other than science was also well verified. Our approach sheds light on unbiased and quantitative analysis of scientific evolution in society, and may provide a useful basis for policy-making.

Micro-PIXE analysis of trace element concentrations of natural rubies from different locations in Myanmar

NASA Astrophysics Data System (ADS)

Sanchez, J. L.; Osipowicz, T.; Tang, S. M.; Tay, T. S.; Win, T. T.

1997-07-01

The trace element concentrations found in geological samples can shed light on the formation process. In the case of gemstones, which might be of artificial or natural origin, there is also considerable interest in the development of methods that provide identification of the origin of a sample. For rubies, trace element concentrations present in natural samples were shown previously to be significant indicators of the region of origin [S.M. Tang et al., Appl. Spectr. 42 (1988) 44, and 43 (1989) 219]. Here we report the results of micro-PIXE analyses of trace element (Ti, V, Cr, Fe, Cu and Ga) concentrations of a large set ( n = 130) of natural rough rubies from nine locations in Myanmar (Burma). The resulting concentrations are subjected to statistical analysis. Six of the nine groups form clusters when the data base is evaluated using tree clustering and principal component analysis.

Structural Properties of the Brazilian Air Transportation Network.

PubMed

Couto, Guilherme S; da Silva, Ana Paula Couto; Ruiz, Linnyer B; Benevenuto, Fabrício

2015-09-01

The air transportation network in a country has a great impact on the local, national and global economy. In this paper, we analyze the air transportation network in Brazil with complex network features to better understand its characteristics. In our analysis, we built networks composed either by national or by international flights. We also consider the network when both types of flights are put together. Interesting conclusions emerge from our analysis. For instance, Viracopos Airport (Campinas City) is the most central and connected airport on the national flights network. Any operational problem in this airport separates the Brazilian national network into six distinct subnetworks. Moreover, the Brazilian air transportation network exhibits small world characteristics and national connections network follows a power law distribution. Therefore, our analysis sheds light on the current Brazilian air transportation infrastructure, bringing a novel understanding that may help face the recent fast growth in the usage of the Brazilian transport network.

A metaphor analysis of recovering substance abusers' sensemaking of medication-assisted treatment.

PubMed

Malvini Redden, Shawna; Tracy, Sarah J; Shafer, Michael S

2013-07-01

In this study, we examined metaphors invoked by people recovering from opioid dependence as they described the challenges and successes of using medication-assisted treatment. Metaphors provide linguistic tools for expressing issues that are confusing, complex, hidden, and difficult to state analytically or literally. Using data from eight focus groups with 68 participants representing four ethnic minority groups, we conducted a grounded analysis to show how recovering substance users communicatively constructed addiction and recovery. The primary medication, methadone, was framed as "liquid handcuffs" that allowed those in recovery to quit "hustling," get "straight," and find "money in their pockets." Nonetheless, methadone also served as a "crutch," leaving them still feeling like "users" with "habits" who "came up dirty" to friends and family. In this analysis, we tease out implications of these metaphors, and how they shed light on sensemaking, agency, and related racial- and class-based structural challenges in substance abuse recovery.

Anatomy of Scientific Evolution

PubMed Central

Yun, Jinhyuk; Kim, Pan-Jun; Jeong, Hawoong

2015-01-01

The quest for historically impactful science and technology provides invaluable insight into the innovation dynamics of human society, yet many studies are limited to qualitative and small-scale approaches. Here, we investigate scientific evolution through systematic analysis of a massive corpus of digitized English texts between 1800 and 2008. Our analysis reveals great predictability for long-prevailing scientific concepts based on the levels of their prior usage. Interestingly, once a threshold of early adoption rates is passed even slightly, scientific concepts can exhibit sudden leaps in their eventual lifetimes. We developed a mechanistic model to account for such results, indicating that slowly-but-commonly adopted science and technology surprisingly tend to have higher innate strength than fast-and-commonly adopted ones. The model prediction for disciplines other than science was also well verified. Our approach sheds light on unbiased and quantitative analysis of scientific evolution in society, and may provide a useful basis for policy-making. PMID:25671617

Field Testing of Telemetry for Demand Response Control of Small Loads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lanzisera, Steven; Weber, Adam; Liao, Anna

The electricity system in California, from generation through loads, must be prepared for high renewable penetration and increased electrification of end uses while providing increased resilience and lower operating cost. California has an aggressive renewable portfolio standard that is complemented by world-leading greenhouse gas goals. The goal of this project was to evaluate methods of enabling fast demand response (DR) signaling to small loads for low-cost site enablement. We used OpenADR 2.0 to meet telemetry requirements for providing ancillary services, and we used a variety of low-cost devices coupled with open-source software to enable an end-to-end fast DR. The devices,more » architecture, implementation, and testing of the system is discussed in this report. We demonstrate that the emerging Internet of Things (IoT) and Smart Home movements provide an opportunity for diverse small loads to provide fast, low-cost demand response. We used Internet-connected lights, thermostats, load interruption devices, and water heaters to demonstrate an ecosystem of controllable devices. The system demonstrated is capable of providing fast load shed for between 20 dollars and $300 per kilowatt (kW) of available load. The wide range results from some loads may have very low cost but also very little shed capability (a 10 watt [W] LED light can only shed a maximum of 10 W) while some loads (e.g., water heaters or air conditioners) can shed several kilowatts but have a higher initial cost. These costs, however, compare well with other fast demand response costs, with typically are over $100/kilowatt of shed. We contend these loads are even more attractive than their price suggests because many of them will be installed for energy efficiency or non-energy benefits (e.g., improved lighting quality or controllability), and the ability to use them for fast DR is a secondary benefit. Therefore the cost of enabling them for DR may approach zero if a software-only solution can be deployed to enable fast DR after devices are installed for other reasons. We recommend that the DR research community continue to engage with the IoT community to encourage the use of documented and open development interfaces. A library of device drivers and machine-readable interface specifications would significantly reduce the burden on users or system integrators for deploying systems in large numbers of buildings in California.« less

Volatile Metal-Bearing Phases Associated with Cumulus Pigeonite in Chassigny — Indications for the Petrogenesis

NASA Astrophysics Data System (ADS)

Krzesinska, A. M.; Schofield, P. F.; Smith, C. L.; Salge, T.; Almeida, N. V.; Russell, S. S.

2017-07-01

Some Chassigny fragments contain cumulus pigeonite. They host Pb,Hg,Sn,Au,Ag-sulfides. This supports the model of infiltration metasomatism during crystallization of Chassigny and shed light on the potential co-magmatism of Chassigny and nakhlites.

Modality and Children's Scope Understanding

ERIC Educational Resources Information Center

Liu, Chin-Ting Jimbo; Lee, Hsiu-Fen Hélène

2014-01-01

This study intends to shed light on the inconclusive argument pertaining to children's acquisition of logical form (LF) operation. Specifically, we examined children's interpretations of sentences with the ambiguous modal verb "yinggai" "should," like "Xiaohua yinggai shangchuang shuijiao le", whose meanings…

Fraternization in Accounting Firms: A Case Study

ERIC Educational Resources Information Center

Heinze, Tim; Kizirian, Tim; Leese, Wallace

2004-01-01

This case study sheds light on how to avoid risks caused by manager-subordinate dating relationships (fraternization) such as employee misunderstandings, retaliation charges, favoritism complaints, wrongful termination lawsuits, and sexual harassment lawsuits, as well as associated ethical risks. Risk avoidance can be accomplished through a better…

Human Behavior, Learning, and the Developing Brain: Typical Development

ERIC Educational Resources Information Center

Coch, Donna, Ed.; Fischer, Kurt W., Ed.; Dawson, Geraldine, Ed.

2010-01-01

This volume brings together leading authorities from multiple disciplines to examine the relationship between brain development and behavior in typically developing children. Presented are innovative cross-sectional and longitudinal studies that shed light on brain-behavior connections in infancy and toddlerhood through adolescence. Chapters…

Self-Control and Deviant Peer Network Structure

ERIC Educational Resources Information Center

McGloin, Jean Marie; Shermer, Lauren O'Neill

2009-01-01

From learning and opportunity perspectives, peer group structural dimensions shed light on social processes that can amplify or ameliorate the risk of having delinquent friends. Previous research has not accounted for a primary criminological variable, self-control, limiting theoretical clarity. The authors developed three hypotheses about…

Capability and Health Functioning in Ethiopian Households

ERIC Educational Resources Information Center

Mabsout, Ramzi

2011-01-01

From a recent Ethiopian representative household survey this paper empirically operationalizes concepts from the capability approach to shed light on the relationship between conversion factors, capability inputs and health functionings. The subjects of the study are women in partnership. The results suggest their health functionings are…

Investigation of relationships between physical parameters and neuro-physiological response to head impact.

DOT National Transportation Integrated Search

1988-06-01

The aim of this study was to shed some light on brain injuries following blows to the head by means of the methods of both cognitive psychology and electrophysiology. More precisely, boxers' attention mechanisms and their capacity of orienting toward...

Magnetic resonance microscopy of prostate tissue: How basic science can inform clinical imaging development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bourne, Roger

2013-03-15

This commentary outlines how magnetic resonance imaging (MRI) microscopy studies of prostate tissue samples and whole organs have shed light on a number of clinical imaging mysteries and may enable more effective development of new clinical imaging methods.

Creating Livable Communities

ERIC Educational Resources Information Center

Oberlink, Mia R.

2006-01-01

This report identifies barriers to developing livable communities and sheds light on potential methods for overcoming these barriers. It identifies and highlights multiple strategies that may be applied to the design and support of livable community principles. The identified strategies have been initiated by federal and state government agencies…

More Supernova Surprises

DTIC Science & Technology

2010-09-24

originated in South America. E veryone appreciates the beauty of dai- sies, chrysanthemums, and sunfl ow- ers, and many of us enjoy eating lettuce ...few fossils. On page 1621 of this issue, Barreda et al. ( 1) describe an unusually well-preserved new fossil that sheds light on the history of

Dynamic Open Inquiry Performances of High-School Biology Students

ERIC Educational Resources Information Center

Zion, Michal; Sadeh, Irit

2010-01-01

In examining open inquiry projects among high-school biology students, we found dynamic inquiry performances expressed in two criteria: "changes occurring during inquiry" and "procedural understanding". Characterizing performances in a dynamic open inquiry project can shed light on both the procedural and epistemological…

Zebrafish models flex their muscles to shed light on muscular dystrophies.

PubMed

Berger, Joachim; Currie, Peter D

2012-11-01

Muscular dystrophies are a group of genetic disorders that specifically affect skeletal muscle and are characterized by progressive muscle degeneration and weakening. To develop therapies and treatments for these diseases, a better understanding of the molecular basis of muscular dystrophies is required. Thus, identification of causative genes mutated in specific disorders and the study of relevant animal models are imperative. Zebrafish genetic models of human muscle disorders often closely resemble disease pathogenesis, and the optical clarity of zebrafish embryos and larvae enables visualization of dynamic molecular processes in vivo. As an adjunct tool, morpholino studies provide insight into the molecular function of genes and allow rapid assessment of candidate genes for human muscular dystrophies. This unique set of attributes makes the zebrafish model system particularly valuable for the study of muscle diseases. This review discusses how recent research using zebrafish has shed light on the pathological basis of muscular dystrophies, with particular focus on the muscle cell membrane and the linkage between the myofibre cytoskeleton and the extracellular matrix.

Enhanced absorption of light by charged nanoparticles.

PubMed

Rosenkrantz, Etai; Arnon, Shlomi

2010-04-15

We found that various charged nanoparticles (NPs) can raise the attenuation of electromagnetic (EM) radiation over 30 times more efficiently during resonance in comparison to equivalent noncharged particles for a given set of parameters. A condition that indicates a state of resonance between the incident EM radiation and the NP surface excitations is mathematically derived. Our results shed light on the mechanism responsible for the strong absorption of light by such charged NPs. The outcome of this research could help to design a new generation of communication devices as well as a new technique for biological cell imaging.

Manipulation of light wavelength at appropriate growth stage to enhance biomass productivity and fatty acid methyl ester yield using Chlorella vulgaris.

PubMed

Kim, Dae Geun; Lee, Changsu; Park, Seung-Moon; Choi, Yoon-E

2014-05-01

LEDs light offer several advantages over the conventional lamps, thereby being considered as the optimal light sources for microalgal cultivation. In this study, various light-emitting diodes (LEDs) especially red and blue color with different light wavelengths were employed to explore the effects of light source on phototrophic cultivation of Chlorella vulgaris. Blue light illumination led to significantly increased cell size, whereas red light resulted in small-sized cell with active divisions. Based on the discovery of the effect of light wavelengths on microalgal biology, we then applied appropriate wavelength at different growth stages; blue light was illuminated first and then shifted to red light. By doing so, biomass and lipid productivity of C. vulgaris could be significantly increased, compared to that in the control. These results will shed light on a novel approach using LED light for microalgal biotechnology. Copyright © 2014 Elsevier Ltd. All rights reserved.

Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration.

PubMed

Bachtrog, Doris

2013-02-01

The human Y chromosome is intriguing not only because it harbours the master-switch gene that determines gender but also because of its unusual evolutionary history. The Y chromosome evolved from an autosome, and its evolution has been characterized by massive gene decay. Recent whole-genome and transcriptome analyses of Y chromosomes in humans and other primates, in Drosophila species and in plants have shed light on the current gene content of the Y chromosome, its origins and its long-term fate. Furthermore, comparative analysis of young and old Y chromosomes has given further insights into the evolutionary and molecular forces triggering Y-chromosome degeneration and into the evolutionary destiny of the Y chromosome.

Left ventricular fluid mechanics: the long way from theoretical models to clinical applications.

PubMed

Pedrizzetti, Gianni; Domenichini, Federico

2015-01-01

The flow inside the left ventricle is characterized by the formation of vortices that smoothly accompany blood from the mitral inlet to the aortic outlet. Computational fluid dynamics permitted to shed some light on the fundamental processes involved with vortex motion. More recently, patient-specific numerical simulations are becoming an increasingly feasible tool that can be integrated with the developing imaging technologies. The existing computational methods are reviewed in the perspective of their potential role as a novel aid for advanced clinical analysis. The current results obtained by simulation methods either alone or in combination with medical imaging are summarized. Open problems are highlighted and perspective clinical applications are discussed.

An unusual petition for posthumous sperm retrieval? What does it add to the debate?

PubMed

Sarig, Shelly; Tabak, Nili

2008-06-01

Posthumous sperm retrieval is still a controversial procedure. The Israel Ministry of Health has recently issued guidelines to regulate the procedure and a recent unusual petition in Israel for posthumous retrieval sheds new and interesting light on the dilemmas involved. This paper examines the petition, both in its own right and by comparing it to the more frequent situation where the surviving partner of a suddenly deceased man petitions for his sperm to be collected for insemination into herself. The analysis considers the best interests of the child to be born, the good of other family members, the wishes of the deceased and the interests of society as a whole.

What The Oregon Health Study Can Tell Us About Expanding Medicaid

PubMed Central

Allen, Heidi; Baicker, Katherine; Finkelstein, Amy; Taubman, Sarah; Wright, Bill J.

2012-01-01

The recently enacted Patient Protection and Affordable Care Act includes a major expansion of Medicaid to low-income adults in 2014. This paper describes the Oregon Health Study, a randomized controlled trial that will be able to shed some light on the likely effects of such expansions. In 2008, Oregon randomly drew names from a waiting list for its previously closed public insurance program. Our analysis of enrollment into this program found that people who signed up for the waiting list and enrolled in the Oregon Medicaid program were likely to have worse health than those who did not. However, actual enrollment was fairly low, partly because many applicants did not meet eligibility standards. PMID:20679654

Thresholds and the rising pion inclusive cross section

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, S.T.

In the context of the hypothesis of the Pomeron-f identity, it is shown that the rising pion inclusive cross section can be explained over a wide range of energies as a series of threshold effects. Low-mass thresholds are seen to be important. In order to understand the contributions of high-mass thresholds (flavoring), a simple two-channel multiperipheral model is examined. The analysis sheds light on the relation between thresholds and Mueller-Regge couplings. In particular, it is seen that inclusive-, and total-cross-section threshold mechanisms may differ. A quantitative model based on this idea and utilizing previous total-cross-section fits is seen to agreemore » well with experiment.« less

Does multilingualism affect the incidence of Alzheimer's disease?: A worldwide analysis by country.

PubMed

Klein, Raymond M; Christie, John; Parkvall, Mikael

2016-12-01

It has been suggested that the cognitive requirements associated with bi- and multilingual processing provide a form of mental exercise that, through increases in cognitive reserve and brain fitness, may delay the symptoms of cognitive failure associated with Alzheimer's disease and other forms of dementia. We collected data on a country-by-country basis that might shed light on this suggestion. Using the best available evidence we could find, the somewhat mixed results we obtained provide tentative support for the protective benefits of multilingualism against cognitive decline. But more importantly, this study exposes a critical issue, which is the need for more comprehensive and more appropriate data on the subject.

German words: still used by Japanese obstetrics and gynecology doctors.

PubMed

Matsubara, Shigeki

2018-03-01

German used to be frequently employed in Japanese obstetric and gynecologic (OBGYN) practice; however, it is now less frequently used. Description and analysis of this situation may shed some light on the change of OBGYN practice and education in Japan, which may at least partly hold true to counties other than Japan. Three eras were classified according to the relationship between German and Japanese OBGYN, with each era characterized. Frequently used German words in Japanese OBGYN practice were described as examples. German words have become less frequently used with each successive generation. Even though English may suffice in practical OBGYN practice, German usage will still be passed on to these new generations.

Quantifying the Beauty of Words: A Neurocognitive Poetics Perspective

PubMed Central

Jacobs, Arthur M.

2017-01-01

In this paper I would like to pave the ground for future studies in Computational Stylistics and (Neuro-)Cognitive Poetics by describing procedures for predicting the subjective beauty of words. A set of eight tentative word features is computed via Quantitative Narrative Analysis (QNA) and a novel metric for quantifying word beauty, the aesthetic potential is proposed. Application of machine learning algorithms fed with this QNA data shows that a classifier of the decision tree family excellently learns to split words into beautiful vs. ugly ones. The results shed light on surface and semantic features theoretically relevant for affective-aesthetic processes in literary reading and generate quantitative predictions for neuroaesthetic studies of verbal materials. PMID:29311877

Quantifying the Beauty of Words: A Neurocognitive Poetics Perspective.

PubMed

Jacobs, Arthur M

2017-01-01

In this paper I would like to pave the ground for future studies in Computational Stylistics and (Neuro-)Cognitive Poetics by describing procedures for predicting the subjective beauty of words. A set of eight tentative word features is computed via Quantitative Narrative Analysis (QNA) and a novel metric for quantifying word beauty, the aesthetic potential is proposed. Application of machine learning algorithms fed with this QNA data shows that a classifier of the decision tree family excellently learns to split words into beautiful vs. ugly ones. The results shed light on surface and semantic features theoretically relevant for affective-aesthetic processes in literary reading and generate quantitative predictions for neuroaesthetic studies of verbal materials.

Statistical methods to detect novel genetic variants using publicly available GWAS summary data.

PubMed

Guo, Bin; Wu, Baolin

2018-03-01

We propose statistical methods to detect novel genetic variants using only genome-wide association studies (GWAS) summary data without access to raw genotype and phenotype data. With more and more summary data being posted for public access in the post GWAS era, the proposed methods are practically very useful to identify additional interesting genetic variants and shed lights on the underlying disease mechanism. We illustrate the utility of our proposed methods with application to GWAS meta-analysis results of fasting glucose from the international MAGIC consortium. We found several novel genome-wide significant loci that are worth further study. Copyright © 2018 Elsevier Ltd. All rights reserved.

Motility, Force Generation, and Energy Consumption of Unicellular Parasites.

PubMed

Hochstetter, Axel; Pfohl, Thomas

2016-07-01

Motility is a key factor for pathogenicity of unicellular parasites, enabling them to infiltrate and evade host cells, and perform several of their life-cycle events. State-of-the-art methods of motility analysis rely on a combination of optical tweezers with high-resolution microscopy and microfluidics. With this technology, propulsion forces, energies, and power generation can be determined so as to shed light on the motion mechanisms, chemotactic behavior, and specific survival strategies of unicellular parasites. With these new tools in hand, we can elucidate the mechanisms of motility and force generation of unicellular parasites, and identify ways to manipulate and eventually inhibit them. Copyright © 2016 Elsevier Ltd. All rights reserved.

Andreev Bound States Formation and Quasiparticle Trapping in Quench Dynamics Revealed by Time-Dependent Counting Statistics.

PubMed

Souto, R Seoane; Martín-Rodero, A; Yeyati, A Levy

2016-12-23

We analyze the quantum quench dynamics in the formation of a phase-biased superconducting nanojunction. We find that in the absence of an external relaxation mechanism and for very general conditions the system gets trapped in a metastable state, corresponding to a nonequilibrium population of the Andreev bound states. The use of the time-dependent full counting statistics analysis allows us to extract information on the asymptotic population of even and odd many-body states, demonstrating that a universal behavior, dependent only on the Andreev state energy, is reached in the quantum point contact limit. These results shed light on recent experimental observations on quasiparticle trapping in superconducting atomic contacts.

Porphyromonas gingivalis-mediated shedding of extracellular matrix metalloproteinase inducer (EMMPRIN) by oral epithelial cells: a potential role in inflammatory periodontal disease.

PubMed

Feldman, Mark; La, Vu Dang; Lombardo Bedran, Telma Blanca; Palomari Spolidorio, Denise Madalena; Grenier, Daniel

2011-12-01

Extracellular matrix metalloproteinase inducer (EMMPRIN) or CD147 is a transmembrane glycoprotein expressed by various cell types, including oral epithelial cells. Recent studies have brought evidence that EMMPRIN plays a role in periodontitis. In the present study, we investigated the effect of Porphyromonas gingivalis, a major pathogen in chronic periodontitis, on the shedding of membrane-anchored EMMPRIN and on the expression of the EMMPRIN gene by oral epithelial cells. A potential contribution of shed EMMPRIN to the inflammatory process of periodontitis was analyzed by evaluating the effect of recombinant EMMPRIN on cytokine and matrix metalloproteinase (MMP) secretion by human gingival fibroblasts. ELISA and immunofluorescence analyses revealed that P. gingivalis mediated the shedding of epithelial cell-surface EMMPRIN in a dose- and time-dependent manner. Cysteine proteinase (gingipain)-deficient P. gingivalis mutants were used to demonstrate that both Arg- and Lys-gingipain activities are involved in EMMPRIN shedding. Real-time PCR showed that P. gingivalis had no significant effect on the expression of the EMMPRIN gene in epithelial cells. Recombinant EMMPRIN induced the secretion of IL-6 and MMP-3 by gingival fibroblasts, a phenomenon that appears to involve mitogen activated protein kinases. The present study brought to light a new mechanism by which P. gingivalis can promote the inflammatory response during periodontitis. Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Role of quantum correlations in light-matter quantum heat engines

NASA Astrophysics Data System (ADS)

Barrios, G. Alvarado; Albarrán-Arriagada, F.; Cárdenas-López, F. A.; Romero, G.; Retamal, J. C.

2017-11-01

We study a quantum Otto engine embedding a working substance composed of a two-level system interacting with a harmonic mode. The physical properties of the substance are described by a generalized quantum Rabi model arising in superconducting circuit realizations. We show that light-matter quantum correlation reduction during the hot bath stage and adiabatic stages act as an indicator for enhanced work extraction and efficiency, respectively. Also, we demonstrate that the anharmonic spectrum of the working substance has a direct impact on the transition from heat engine into refrigerator as the light-matter coupling is increased. These results shed light on the search for optimal conditions in the performance of quantum heat engines.

Digenetic larvae in Schistosome snails from El Fayoum, Egypt with detection of Schistosoma mansoni in the snail by PCR.

PubMed

Aboelhadid, Shawky M; Thabet, Marwa; El-Basel, Dayhoum; Taha, Ragaa

2016-09-01

The present study aims to detect the digenetic larvae infections in Bulinus truncatus and Biomphalaria alexandrina snails and also PCR detection of Schistosoma mansoni infection. The snails were collected from different branches of Yousef canal and their derivatives in El Fayoum Governorate. The snails were investigated for infection through induction of cercarial shedding by exposure to light and crushing of the snails. The shed cercariae were S. mansoni, Pharyngeate longifurcate type I and Pharyngeate longifurcate type II from B. alexandrina, while that found in B. truncatus were Schitosoma haematobium and Xiphidiocercaria species cercariae. The seasonal prevalence of infection was discussed. Polymerase chain reaction was used for the detection of S. mansoni in the DNA from field collected infected and non infected snails. The results of PCR showed that the pool of B. alexandrina snails which shed S. mansoni cercariae in the laboratory, gave positive reaction in the samples. Pooled samples of field collected B. alexandrina that showed negative microscopic shedding of cercariae gave negative and positive PCR in a consecutive manner. Accordingly, a latent infection in the snail (negative microscopic) could be detected by using PCR.

Purification and Characterization of the Danaus Plexippus Cryptochromes

DTIC Science & Technology

2006-01-01

It was also recently discovered that Apis 13 mellifera (honey bee) possess only one mCry-like cryptochrome (28). Additional components of the honey...and phylogenetic analyses reveal mammalian-like clockwork in the honey bee ( Apis mellifera ) and shed new light on the molecular evolution of the

Equity, Institutional Diversity and Regional Development: A Cross-Country Comparison

ERIC Educational Resources Information Center

Pinheiro, Rómulo; Charles, David; Jones, Glen A.

2016-01-01

This paper investigates historical and current developments regarding governmental policies aimed at enhancing spatial equity (access) or decentralisation of higher education provision in three countries--Australia, Canada and Norway. We then shed light on the links or interrelations between policy objectives and initiatives and institutional…

A study of the review and comment phase of the environmental impact statement : draft and negative.

DOT National Transportation Integrated Search

1972-01-01

This study examined the agencies that review the environmental impact statements (EIS) prepared on highway projects and was an attempt to shed light on the functions, personnel, and problems of the offices that saw the statements. The report covered ...

Implementing an Online Vocabulary Training Program

ERIC Educational Resources Information Center

Robertson, Charles E.

2015-01-01

Although vocabulary acquisition research has shed much light on practical methods for increasing lexical knowledge (Nation, 1994), many foreign language teachers hesitate to implement focused vocabulary-training programs in their classrooms. The reasons most often cited for this hesitation are associated with the difficult tasks of creating,…

Toxic Rain in Class: Classroom Interpersonal Microaggressions

ERIC Educational Resources Information Center

Suárez-Orozco, Carola; Casanova, Saskias; Martin, Margary; Katsiaficas, Dalal; Cuellar, Veronica; Smith, Naila Antonia; Dias, Sandra Isabel

2015-01-01

In this article we share exploratory findings from a study that captures microaggressions (MAs) in vivo to shed light on how they occur in classrooms. These brief and commonplace indignities communicate derogatory slights and insults toward individuals of underrepresented status contributing to invalidating and hostile learning experiences. Our…

Sustainable School Leadership: The Teachers' Perspective

ERIC Educational Resources Information Center

Cook, John W.

2014-01-01

Sustainable school leadership is essential to the academic growth of students and professional growth of faculty and staff. Shedding light on what constitutes sustainable leadership from the perspective of teachers will increase our understanding of how specific leadership practices and processes impact those in the learning community who are…

Car Stopping Distance on a Tabletop

ERIC Educational Resources Information Center

Haugland, Ole Anton

2013-01-01

Stopping distances in car braking can be an intriguing topic in physics teaching. It illustrates some basic principles of physics, and sheds valuable light on students' attitude towards aggressive driving. Due to safety considerations, it can be difficult to make experiments with actual car braking. (Contains 2 figures.)

An Examination of Attachment Styles and Social Skills of University Students

ERIC Educational Resources Information Center

Dereli, Esra; Karakus, Ozlem

2011-01-01

Introduction: Attachment organization across the lifespan and across generations, long-term predictions from attachment organization to later psychosocial functioning, and the possibility of altering attachment organization with intervention suggest that attachment theory may potentially shed valuable light on adult social development and deviant…

Epidemiological Perspectives on Maltreatment Prevention

ERIC Educational Resources Information Center

Wulczyn, Fred

2009-01-01

Fred Wulczyn explores how data on the incidence and distribution of child maltreatment shed light on planning and implementing maltreatment prevention programs. He begins by describing and differentiating among the three primary sources of national data on maltreatment. Wulczyn then points out several important patterns in the data. The first…

Studies shed light on youth sex and drinking. Parents and teens don't see eye to eye.

PubMed

2004-01-01

Researchers looking into early sexual behavior and attitudes about sex among youths have found that alcohol use does play a role in sexual initiation, and that children have different attitudes about sexual behavior even as young as preteens.

Sartrean Reflections on Education for Rational Character.

ERIC Educational Resources Information Center

Knitter, William

1981-01-01

To shed light on whether reason or attitudes, the intellect or the emotions, should be the primary focus of educational efforts, the writings of Jean Paul Sartre on human motivation are digested. Educators should foster the conscious and deliberate acceptance of the human condition of freedom. (PP)

Technological Advances and the Study of Reading.

ERIC Educational Resources Information Center

Henk, William A.

Recent technological advances in neuroanatomy and neurophysiology have unearthed structural and functional patterns in the brain that can be associated with severe reading disabilities. As a response, this paper examines several computer-driven technologies whose capabilities shed light on brain-related issues germane to reading, with the intent…

Spotlight on the positive effects of the ladybird Harmonia axyridis on agriculture

USDA-ARS?s Scientific Manuscript database

In the midst of considerable negativity surrounding the ladybird Harmonia axyridis (Pallas), this paper sheds some light on the positive effects that this predator has had on agriculture. Using resources available at the USDA, National Agricultural Library (DigiTop literature database, Navigator pla...

Australian Students' Appreciation of the Greenhouse Effect and the Ozone Hole.

ERIC Educational Resources Information Center

Fisher, Brian

1998-01-01

Examines students' explanations of the greenhouse effect and the hole in the ozone layer, using a life-world and scientific dichotomy. Illuminates ideas often expressed in classrooms and sheds light on the progression in students' developing powers of explanation. Contains 17 references. (DDR)

Academic Literacies: The Word Is Not Enough

ERIC Educational Resources Information Center

Richards, Kendall; Pilcher, Nick

2018-01-01

For Academic Literacies, the world is textually mediated; written texts and what informs them reveal elements such as subject-discipline practices. Furthermore, multi-modalities, for example, visual representation, inform written text, and multiple methods of inquiry, including interviews, shed light on written text production. In this article we…

Shedding Light, Reducing the Heat

ERIC Educational Resources Information Center

Perry, Mary

2006-01-01

Underlying the very heated debate over California's education budget for 2005-2006--and the battle over Proposition 76 on the November ballot--were two very different perspectives on school funding. These fundamental differences in perspective can stymie efforts to effect meaningful change. However, the Governor's Advisory Committee on Education…

Student Misconceptions of an Electric Circuit: What Do They Mean?

ERIC Educational Resources Information Center

Fredette, Norman H.; Clement, John J.

1981-01-01

Discusses a common misconception in the area of electric circuits at the level of introductory college physics. The data, collected from clinical interviews, shed light on the cognitive sources of misconception. Also discusses some implications for laboratory approaches used in science courses. (Author/SK)

[Patterns, predictors, and personalization in pulmonary arterial hypertension].

PubMed

Kawut, Steven M

2014-06-01

Epidemiologic patterns of pulmonary arterial hypertension differ by era and region and may shed light on the pathophysiology and treatment of the disease. New efforts to target one or more of the recently studied therapies could establish personalized medicine as standard care in pulmonary arterial hypertension.

Performance Theory: Southeast Asia.

ERIC Educational Resources Information Center

Kirby, Michael, Ed.

1979-01-01

Focusing on the contemporary theatre in Southeast Asia, this journal issue sheds light on the intercultural relationships that exist between that part of the world and the Western world. In addition to a transcript of a Balinese "topeng" (storytelling) performance, the journal contains eight articles that provide information on the…

Addressing Phonological Questions with Ultrasound

ERIC Educational Resources Information Center

Davidson, Lisa

2005-01-01

Ultrasound can be used to address unresolved questions in phonological theory. To date, some studies have shown that results from ultrasound imaging can shed light on how differences in phonological elements are implemented. Phenomena that have been investigated include transitional schwa, vowel coalescence, and transparent vowels. A study of…

A View from Albemarle

ERIC Educational Resources Information Center

Holt, Thaddeus

1977-01-01

This paper was originally delivered in July of 1975, within a few weeks of the Supreme Court's decision in the case of "Albemarle Paper Company v. Moody". Its intent is to shed light on the interrelationship between the practice of industrial psychology and the judicial process in operation. (Editor/RK)

Multivariate analysis and extraction of parameters in resistive RAMs using the Quantum Point Contact model

NASA Astrophysics Data System (ADS)

Roldán, J. B.; Miranda, E.; González-Cordero, G.; García-Fernández, P.; Romero-Zaliz, R.; González-Rodelas, P.; Aguilera, A. M.; González, M. B.; Jiménez-Molinos, F.

2018-01-01

A multivariate analysis of the parameters that characterize the reset process in Resistive Random Access Memory (RRAM) has been performed. The different correlations obtained can help to shed light on the current components that contribute in the Low Resistance State (LRS) of the technology considered. In addition, a screening method for the Quantum Point Contact (QPC) current component is presented. For this purpose, the second derivative of the current has been obtained using a novel numerical method which allows determining the QPC model parameters. Once the procedure is completed, a whole Resistive Switching (RS) series of thousands of curves is studied by means of a genetic algorithm. The extracted QPC parameter distributions are characterized in depth to get information about the filamentary pathways associated with LRS in the low voltage conduction regime.

Anion binding by bambus[6]uril probed in the gas phase and in solution.

PubMed

Révész, Agnes; Schröder, Detlef; Svec, Jan; Wimmerová, Michaela; Sindelar, Vladimir

2011-10-20

Electrospray ionization mass spectrometry (ESI-MS) is used to probe the binding of small anions to the macrocycle of bambus[6]uril. For the halide ions, the experimental patterns suggest F(-) < Cl(-) < Br(-) < I(-), which is consistent with the order of anion binding found in the condensed phase. Parallel equilibrium studies in the condensed phase establish the association constants of halide anions and bambus[6]uril in mixed solvents. A detailed analysis of the mass spectrometric data is used to shed light on the correlations between the binding constants in the condensed phase and the ion abundances observed using ESI-MS. From the analysis it becomes apparent that ESI-MS can indeed represent the situation in solution to some extent, but the sampling in the gas-phase experiment is not 1:1 compared to that in solution.

Phylogeny and comparative genome analysis of a Basidiomycete fungi

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riley, Robert W.; Salamov, Asaf; Grigoriev, Igor

2011-03-14

Fungi of the phylum Basidiomycota, make up some 37percent of the described fungi, and are important from the perspectives of forestry, agriculture, medicine, and bioenergy. This diverse phylum includes the mushrooms, wood rots, plant pathogenic rusts and smuts, and some human pathogens. To better understand these important fungi, we have undertaken a comparative genomic analysis of the Basidiomycetes with available sequenced genomes. We report a phylogeny that sheds light on previously unclear evolutionary relationships among the Basidiomycetes. We also define a `core proteome? based on protein families conserved in all Basidiomycetes. We identify key expansions and contractions in protein familiesmore » that may be responsible for the degradation of plant biomass such as cellulose, hemicellulose, and lignin. Finally, we speculate as to the genomic changes that drove such expansions and contractions.« less

Sugarcane smut: shedding light on the development of the whip-shaped sorus

PubMed Central

Marques, João Paulo R.; Appezzato-da-Glória, Beatriz; Piepenbring, Meike; Massola Jr, Nelson S.; Monteiro-Vitorello, Claudia B.

2017-01-01

Background and Aims Sugarcane smut is caused by the fungus Sporisorium scitamineum (Ustilaginales/Ustilaginomycotina/Basidiomycota), which is responsible for losses in sugarcane production worldwide. Infected plants show a profound metabolic modification resulting in the development of a whip-shaped structure (sorus) composed of a mixture of plant tissues and fungal hyphae. Within this structure, ustilospores develop and disseminate the disease. Despite the importance of this disease, a detailed histopathological analysis of the plant–pathogen interaction is lacking. Methods The whip-shaped sorus was investigated using light microscopy, scanning and transmission electron microscopy, histochemical tests and epifluorescence microscopy coupled with deconvolution. Key Results Sorus growth is mediated by intercalary meristem activity at the base of the sorus, where the fungus causes partial host cell wall degradation and formation of intercellular spaces. Sporogenesis in S. scitamineum is thallic, with ustilospore initials in intercalary or terminal positions, and mostly restricted to the base of the sorus. Ustilospore maturation is centrifugal in relation to the ground parenchyma and occurs throughout the sorus median region. At the apex of the sorus, the fungus produces sterile cells and promotes host cell detachment. Hyphae are present throughout the central axis of the sorus (columella). The plant cell produces callose around the intracellular hyphae as well as inside the papillae at the infection site. Conclusions The ontogeny of the whip-shaped sorus suggests that the fungus can cause the acropetal growth in the intercalary meristem. The sporogenesis of S. scitamineum was described in detail, demonstrating that the spores are formed exclusively at the base of the whip. Light was also shed on the nature of the sterile cells. The presence of the fungus alters the host cell wall composition, promotes its degradation and causes the release of some peripheral cells of the sorus. Finally, callose was observed around fungal hyphae in infected cells, suggesting that deposition of callose by the host may act as a structural response to fungal infection. PMID:27568298

Pioneer Professional: General John M. Schofield and the Development of a Professional Officer Corps, 1888-1895.

DTIC Science & Technology

1982-04-23

explained the limited scope of his study and in doing so shed some light on the current thought concerning Schofield’s later career: Viewing the Civil War...war became the preoc- cupation of military forces in times of peace. In light of these developments, officership became universally recog- nized as a...calculated method of combat leadership reflected his urbane , sophisticated personality. While he did not achieve the spectacular results that commanders

Teaching: in light of Noel Gough's and Ajay Sharma's articles

NASA Astrophysics Data System (ADS)

Pouliot, Chantal

2017-12-01

In their articles, Ajay Sharma (Cult Stud Sci Educ, doi: 10.1007/s11422-017-9835-z, 2017) and Noel Gough (Cult Stud Sci Educ, doi: 10.1007/s11422-017-9834-0, 2017) shed light on the impact neoliberalism has on the teaching of science and suggest ways to ensure that science education remains critical and socially equitable. In this paper, I illustrate how their proposals influenced my instructional choices during the fall of 2016 in a course entitled Epistemology and Education.

Spectrum Project

NASA Image and Video Library

2017-10-16

Dr. Scott Shipley of Ascentech Enterprises makes an adjustment to the Spectrum unit. He is the project engineer for the effort working under the Engineering Services Contract at NASA's Kennedy Space Center. The device is being built for use aboard the International Space Station and is designed to expose different organisms to different color of fluorescent light while a camera records what's happening with time-laps imagery. Results from the Spectrum project will shed light on which living things are best suited for long-duration flights into deep space.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Yang; Liu, Zhiqiang, E-mail: lzq@semi.ac.cn, E-mail: spring@semi.ac.cn; Yi, Xiaoyan, E-mail: lzq@semi.ac.cn, E-mail: spring@semi.ac.cn

To evaluate electron leakage in InGaN/GaN multiple quantum well (MQW) light emitting diodes (LEDs), analytic models of ballistic and quasi-ballistic transport are developed. With this model, the impact of critical variables effecting electron leakage, including the electron blocking layer (EBL), structure of multiple quantum wells (MQWs), polarization field, and temperature are explored. The simulated results based on this model shed light on previously reported experimental observations and provide basic criteria for suppressing electron leakage, advancing the design of InGaN/GaN LEDs.

In Vitro Evaluation and Mechanism Analysis of the Fiber Shedding Property of Textile Pile Debridement Materials

PubMed Central

Fu, Yijun; Xie, Qixue; Lao, Jihong; Wang, Lu

2016-01-01

Fiber shedding is a critical problem in biomedical textile debridement materials, which leads to infection and impairs wound healing. In this work, single fiber pull-out test was proposed as an in vitro evaluation for the fiber shedding property of a textile pile debridement material. Samples with different structural design (pile densities, numbers of ground yarns and coating times) were prepared and estimated under this testing method. Results show that single fiber pull-out test offers an appropriate in vitro evaluation for the fiber shedding property of textile pile debridement materials. Pull-out force for samples without back-coating exhibited a slight escalating trend with the supplement in pile density and number of ground yarn plies, while back-coating process significantly raised the single fiber pull-out force. For fiber shedding mechanism analysis, typical pull-out behavior and failure modes of the single fiber pull-out test were analyzed in detail. Three failure modes were found in this study, i.e., fiber slippage, coating point rupture and fiber breakage. In summary, to obtain samples with desirable fiber shedding property, fabric structural design, preparation process and raw materials selection should be taken into full consideration. PMID:28773428

Persistent photocurrent (PPC) in solution-processed organic thin film transistors: Mechanisms of gate voltage control

NASA Astrophysics Data System (ADS)

Singh, Subhash; Mohapatra, Y. N.

2016-07-01

There is a growing need to understand mechanisms of photoresponse in devices based on organic semiconductor thin films and interfaces. The phenomenon of persistent photocurrent (PPC) has been systematically investigated in solution processed TIPS-Pentacene based organic thin film transistors (OTFTs) as an important example of an organic semiconductor material system. With increasing light intensity from dark to 385 mW/cm2, there is a significant shift in threshold voltage (VTh) while the filed-effect mobility remains unchanged. The OTFT shows large photoresponse under white light illumination due to exponential tail states with characteristic energy parameter of 86 meV. The photo-induced current is observed to persist even for several hours after turning the light off. To investigate the origin of PPC, its quenching mechanism is investigated by a variety of methods involving a combination of gate bias, illumination and temperature. We show that a coherent model of trap-charge induced carrier concentration is able to account for the quenching behavior. Analysis of isothermal transients using time-analyzed transient spectroscopy shows that the emission rates are activated and are also field enhanced due to Poole-Frankel effect. The results shed light on the nature, origin, and energetic distribution of the traps controlling PPC in solution processed organic semiconductors and their interfaces.

Oral and Vaginal Tenofovir for Genital Herpes Simplex Virus Type 2 Shedding in Immunocompetent Women: A Double-Blind, Randomized, Cross-over Trial.

PubMed

Bender Ignacio, Rachel A; Perti, Tara; Magaret, Amalia S; Rajagopal, Sharanya; Stevens, Claire E; Huang, Meei-Li; Selke, Stacy; Johnston, Christine; Marrazzo, Jeanne; Wald, Anna

2015-12-15

Tenofovir is a potent anti-human immunodeficiency virus (HIV) agent that decreased risk of herpes simplex virus type 2 (HSV-2) acquisition in HIV pre-exposure prophylaxis trials. Whether tenofovir has utility in established HSV-2 disease is unclear. We randomized immunocompetent women with symptomatic HSV-2 infection to oral tenofovir disoproxil fumarate (TDF)/placebo vaginal gel, oral placebo/tenofovir (TFV) vaginal gel, or double placebo (ratio 2:2:1) in a one-way cross-over trial. Women collected genital swabs twice daily for HSV PCR during 4-week lead-in and 5-week treatment phases. The primary intent-to-treat end point was within-person comparison of genital HSV shedding and lesion rates. 64 women completed the lead-in phase and were randomized. Neither TDF nor TFV gel decreased overall shedding or lesion rate in the primary analysis; TFV gel decreased quantity of HSV DNA by -0.50 (-0.86-0.13) log10 copies/mL. In the per-protocol analysis, TDF reduced shedding (relative risk [RR] = 0.74, P = .006) and lesion rates (RR = 0.75, P = .032); quantity of virus shed decreased by 0.41 log10 copies/mL. Oral TDF modestly decreased HSV shedding and lesion rate, and quantity of virus shed when used consistently. Vaginal TFV gel decreased quantity of virus shed by 60%. In contrast to effects on HSV-2 acquisition, tenofovir is unlikely to provide clinically meaningful reductions in the frequency of HSV shedding or genital lesions. NCT01448616. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Spanish-Speaking Limited English Proficiency Patients and Call Light Use.

PubMed

Montie, Mary; Galinato, Jose Gabriel; Patak, Lance; Titler, Marita

2016-06-01

Despite a continuous increase of the limited English proficiency (LEP) population in the United States, disparities in the quality of care received in health care systems persist. This qualitative study explores the perceptions of hospitalized LEP patients on their call light use, as well as their perceptions of a prototype of a new multilingual call light system, Eloquence™. Individual interviews were conducted with 10 Spanish-speaking patient participants. Using a constant comparative method, the following themes emerged: (1) reasons for call light use, (2) challenges with communication, (3) patients' adaptation to language barriers, (4) perceived staff responses to call light, and (5) responses to the Eloquence™ demonstration. Data from this study shed light on the patient care experience of LEP patients and can help guide clinicians and administrators in providing culturally and linguistically competent care. © The Author(s) 2016.

Ethnic Studies: A Matrix Model for the Major.

ERIC Educational Resources Information Center

Butler, Johnnella E.

1991-01-01

Ethnic studies' interdisciplinary nature and attention to race, ethnicity, gender, and class offer the scholarship and teaching necessary to a field of study appropriate to the liberal arts curriculum. The discipline sheds light on the nature of Western and American experience, and its development can help transform liberal studies. (MSE)

The Implications of Programme Assessment Patterns for Student Learning

ERIC Educational Resources Information Center

Jessop, Tansy; Tomas, Carmen

2017-01-01

Evidence from 73 programmes in 14 U.K universities sheds light on the typical student experience of assessment over a three-year undergraduate degree. A previous small-scale study in three universities characterised programme assessment environments using a similar method. The current study analyses data about assessment patterns using descriptive…

Inflation Metaphor in the TIME Magazine Corpus

ERIC Educational Resources Information Center

Hu, Chunyu; Liu, Huijie

2016-01-01

A historical perspective on economy metaphor can shed new lights on economic thoughts. Based on the TIME Magazine Corpus (TMC), this paper investigates inflation metaphor over 83 years and compares findings against the economic data over the relatively corresponding period. The results show how inflation, an abstract concept and a normal economic…

Understanding the Black Foster Child through Assessment.

ERIC Educational Resources Information Center

Seligman, Linda

1979-01-01

Sheds light on the difficulties of one of the most problem-ridden segments of our society's young people--minority foster children--and suggests ways to improve the help that these children receive. Results indicate that a satisfactory rapport could be established with these children with moderate effort and that rewarding therapeutic…

The Relationship of Facilitative Functioning to Effective Peer Supervision

ERIC Educational Resources Information Center

Seligman, Linda

1978-01-01

This study investigates peer supervision. The criterion used was counselor trainees' growth in facilitative functioning. The study sought to ascertain whether the facilitative counselor trainee was also the effective peer supervisor, to provide information on evaluating peer-supervisory experience, and to shed light on the most effective…

Neural and Behavioral Correlates of Song Prosody

ERIC Educational Resources Information Center

Gordon, Reyna Leigh

2010-01-01

This dissertation studies the neural basis of song, a universal human behavior. The relationship of words and melodies in the perception of song at phonological, semantic, melodic, and rhythmic levels of processing was investigated using the fine temporal resolution of Electroencephalography (EEG). The observations reported here may shed light on…

Taking Centrioles to the Elimination Round.

PubMed

Schoborg, Todd A; Rusan, Nasser M

2016-07-11

Two recent papers published in The Journal of Cell Biology (Borrego-Pinto et al., 2016) and Science (Pimenta-Marques et al., 2016) have begun to shed light on the mechanism of centriole elimination during female oogenesis, highlighting a protective role for Polo kinase and the pericentriolar material. Published by Elsevier Inc.

Study IDs Genetic Markers that Speed AIDS Progression | Frederick National Laboratory for Cancer Research

Cancer.gov

A study published in the journal Science sheds new light on how a set of human genes can accelerate progression of AIDS-related illness in people living with HIV who are not on treatment. South African scientists led the international research team,

Forensic Psychiatric Perspective on Criminality Associated with Intellectual Disability: A Nationwide Register-Based Study

ERIC Educational Resources Information Center

Mannynsalo, L.; Putkonen, H.; Lindberg, N.; Kotilainen, I.

2009-01-01

Background: Contrasting views exist over the association of intellectual disability (ID) and criminal offending. This nationwide study attempts to shed further light to expand understanding to substantiate the relation between socio-demographic characteristics, psychiatric co-morbidity and criminal behaviour among the Finnish forensic population…

Early Language Learning: Complexity and Mixed Methods

ERIC Educational Resources Information Center

Enever, Janet, Ed.; Lindgren, Eva, Ed.

2017-01-01

This is the first collection of research studies to explore the potential for mixed methods to shed light on foreign or second language learning by young learners in instructed contexts. It brings together recent studies undertaken in Cameroon, China, Croatia, Ethiopia, France, Germany, Italy, Kenya, Mexico, Slovenia, Spain, Sweden, Tanzania and…

School & Society. Learning Content through Culture.

ERIC Educational Resources Information Center

Trueba, Henry T., Ed.; Delgado-Gaitan, Concha, Ed.

Over the last 30 years, educational anthropologists have been exploring the organizational structure of schools and their relationship to society in order to shed light on the complex processes of acquisition, organization, and transmission of cultural knowledge. This volume covers the need to provide a field-based, well-documented cultural…

Shedding Light on the "Science of Small"

ERIC Educational Resources Information Center

Goldston, M. Jenice; Pan, Shanlin; Boykin, Karen; Allison, Elizabeth; Wehby, Scott

2016-01-01

Nanoscience development affects almost every discipline of science, engineering, and technology. Not surprisingly, "the science of small" is also finding its way into science classrooms. In general, "nano" refers to a billionth of a meter--about 1/50,000 the width of a hair follicle. The term "nanoparticle" usually…

The Impact of Information Technology on Research in Science and Engineering.

ERIC Educational Resources Information Center

Morell, Jonathan A.

Several bodies of literature that shed light on some aspects of the relationship between information technology (IT) and research practice in science and engineering are reviewed. Subjects include: (1) the importance of calculation in research endeavors; (2) productivity in science and technology; (3) the philosophical differences between science…

Organisational Learning for School Quality and Health

ERIC Educational Resources Information Center

Lagrosen, Yvonne; Lagrosen, Stefan

2012-01-01

Purpose: The purpose of this paper is to shed light upon the connections between quality management, employee health and organisational learning in a school setting. Design/methodology/approach: The study is based on a quantitative survey. Items measuring health status and values of quality management were included in a questionnaire addressed to…

Academic Professional Development Strategies to Facilitate Educational Changes in Universities

ERIC Educational Resources Information Center

Gonzalez Alonso, Gloria Amparo

2009-01-01

This qualitative within-case study explored how planned educational change in universities can be facilitated through academic professional development strategies. Thus this study attempted to shed some light on the dynamics of educational planned change in universities and their implications for academic professional development of faculty. The…

User-Centered Design of Online Learning Communities

ERIC Educational Resources Information Center

Lambropoulos, Niki, Ed.; Zaphiris, Panayiotis, Ed.

2007-01-01

User-centered design (UCD) is gaining popularity in both the educational and business sectors. This is due to the fact that UCD sheds light on the entire process of analyzing, planning, designing, developing, using, evaluating, and maintaining computer-based learning. "User-Centered Design of Online Learning Communities" explains how…

CAVL: Does It Develop Learner's Attitude?

ERIC Educational Resources Information Center

Maleki, Hojjat; Ghasemi, Ali Aaghar; Moharami, Mehdi

2015-01-01

Individual's response to anything related to the immediate context can form attitudes concerning the learning situation where the language is taught. As an attempt to shed new light on the issues relevant to attitude, this study investigated the extent to which a Computer-Assisted Vocabulary Learning (CAVL), Mandegar, can improve learners'…

Insect vision: a few tricks to regulate flight altitude.

PubMed

Floreano, Dario; Zufferey, Jean-Christophe

2010-10-12

A recent study sheds new light on the visual cues used by Drosophila to regulate flight altitude. The striking similarity with previously identified steering mechanisms provides a coherent basis for novel models of vision-based flight control in insects and robots. Copyright © 2010 Elsevier Ltd. All rights reserved.

The Cleveland Aircraft Fire Tests

NASA Technical Reports Server (NTRS)

Brenneman, James J.; Heine, Donald A.

1968-01-01

On June 30 and July 1, 1966, tests were conducted to evaluate high expansion foam's ability to extend the time for which an aircraft passenger cabin environment would remain survivable during a post-crash fire. While some results tend to confirm those of similar tests, others may shed new light on the problem.

Relevance, New Literacies, & Pragmatic Research for Middle Grades Education

ERIC Educational Resources Information Center

Burns, Leslie David

2008-01-01

This article describes how scholarship from the New Literacy Studies can shed "more light" (Florio-Ruane, 2002) on middle school education and youth literacies, allowing users to examine claims about students, schools, policy, and research. Hypothesizing that shortcomings in early adolescent literacy education have less to do with lack of…

Collective and Individual Dimensions in Peer Positioning in Early Childhood Education

ERIC Educational Resources Information Center

Kultti, Anne; Odenbring, Ylva

2015-01-01

The present study will shed light on peer interaction and children's positioning in preschool. Theoretically, the study takes its point of departure from the concept of interpretive reproduction, which stresses the importance of children's collective actions and participation in cultural production and reproduction. Positioning refers to how…

Ryukyuan Culture.

ERIC Educational Resources Information Center

Trafton, Terry

The Ryukyu Islands of Japan, of which Okinawa is the best known, possess a lengthy history and a sophisticated cultural background, an exploration of which helps to shed light on this area and on mainland Japan. This document is an exposition of Ryukuan culture. Divided into eight sections, the areas covered include: (1) Historical perspective;…

Maternal Work Conditions and Child Development

ERIC Educational Resources Information Center

Felfe, Christina; Hsin, Amy

2012-01-01

How do maternal work conditions, such as psychological stress and physical hazards, affect children's development? Combining data from the Child Development Supplement of the Panel Study of Income Dynamics and the Occupational Information Network allows us to shed some light on this question. We employ various techniques including OLS with…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nazarewicz, W.

The new large detector systems are certain to shed new light on many aspects of nuclear structure. Some of these areas for future studies are discussed. In this contribution the author concentrates on several aspects of nuclear spectroscopy, that will be accessible by modern detector systems (e.g., {gamma}-ray crystal balls or new-generation particle detectors).

The Complex Experience of Learning to Do Research

ERIC Educational Resources Information Center

Emo, Kenneth; Emo, Wendy; Kimn, Jung-Han; Gent, Stephen

2015-01-01

This article examines how student learning is a product of the experiential interaction between person and environment. We draw from the theoretical perspective of complexity to shed light on the emergent, adaptive, and unpredictable nature of students' learning experiences. To understand the relationship between the environment and the student…

An Alternative Model of Special Education Teacher Education Socialization

ERIC Educational Resources Information Center

Young, Kathryn

2008-01-01

The process of organizational socialization sheds light on the difficulty of a university program to effectively socialize its special education teacher candidates into believing and acting on theories of inclusion for students with disabilities in public schools. In general, people are socialized by prior experiences, then the university, then…

Linking Parser Development to Acquisition of Syntactic Knowledge

ERIC Educational Resources Information Center

Omaki, Akira; Lidz, Jeffrey

2015-01-01

Traditionally, acquisition of syntactic knowledge and the development of sentence comprehension behaviors have been treated as separate disciplines. This article reviews a growing body of work on the development of incremental sentence comprehension mechanisms and discusses how a better understanding of the developing parser can shed light on two…

Eye-Witness Memory and Suggestibility in Children with Asperger Syndrome

ERIC Educational Resources Information Center

McCrory, Eamon; Henry, Lucy A.; Happe, Francesca

2007-01-01

Background: Individuals with autism spectrum disorders (ASD) present with a particular profile of memory deficits, executive dysfunction and impaired social interaction that may raise concerns about their recall and reliability in forensic and legal contexts. Extant studies of memory shed limited light on this issue as they involved either…

Wanted: A National Energy Policy

ERIC Educational Resources Information Center

Environmental Science and Technology, 1972

1972-01-01

Recent hearings have shed little light on how the federal government should restructure itself to deal with the mounting energy crisis. Individual viewpoints and personal observations are presented, showing a lack of consensus on the best way to accomplish this. Office of Science and Technology priorities toward a national energy policy are…

Skate Parks as a Context for Adolescent Development

ERIC Educational Resources Information Center

Bradley, Graham L.

2010-01-01

All people influence, and are influenced by, the contexts they inhabit. Leisure contexts are no exception. The current research comprised three studies investigating the links between one leisure context, skate parks, and adolescent development. Using interview, observation, and questionnaire methods, the research shed light on several of the…

Group Matching: Is This a Research Technique to Be Avoided?

ERIC Educational Resources Information Center

Ross, Donald C.; Klein, Donald F.

1988-01-01

The variance of the sample difference and the power of the "F" test for mean differences were studied under group matching on covariates and also under random assignment. Results shed light on systematic assignment procedures advocated to provide more precise estimates of treatment effects than simple random assignment. (TJH)

On cosmology in the laboratory

PubMed Central

Leonhardt, Ulf

2015-01-01

In transformation optics, ideas from general relativity have been put to practical use for engineering problems. This article asks the question how this debt can be repaid. In discussing a series of recent laboratory experiments, it shows how insights from wave phenomena shed light on the quantum physics of the event horizon. PMID:26217062

Medicaid and Family Wealth Transfer

ERIC Educational Resources Information Center

Lee, Jinkook; Kim, Hyungsoo; Tanenbaum, Sandra

2006-01-01

Purpose: This study examines whether the relationship between making familial wealth transfers and becoming a Medicaid recipient sheds light on the current debate about Medicaid estate planning, whereby some elders transfer their assets to their families to qualify for Medicaid. Design and Methods: Using the Health and Retirement Study, we tracked…

Vygotsky's Enlightenment Precursors

ERIC Educational Resources Information Center

Hardcastle, John

2009-01-01

This article seeks to recover a history of ideas about the role of signs in the development of mind that connects Vygotsky to major traditions in Enlightenment language studies. It offers historical perspectives on ideas about thinking and speaking that shed light on the scope and trajectory of Vygotsky's conception of signs as psychological…

"In Reality It's Almost Impossible": CLT-Oriented Curriculum Change

ERIC Educational Resources Information Center

Humphries, Simon; Burns, Anne

2015-01-01

Curriculum innovation is challenging and, as several commentators have reported, moves to introduce communicative language teaching in many contexts internationally have resulted in mixed outcomes, or even failure. In an effort to shed some light on this complex problem, this article focuses on curriculum change through the introduction of new…

Achieving Equity in Higher Education: The Unfinished Agenda

ERIC Educational Resources Information Center

Astin, Alexander W.; Astin, Helen S.

2015-01-01

In this retrospective account of their scholarly work over the past 45 years, Alexander and Helen Astin show how the struggle to achieve greater equity in American higher education is intimately connected to issues of character development, leadership, civic responsibility, and spirituality. While shedding some light on a variety of questions…

The Effect of Health Beliefs on the Smoking Behavior of College Women.

ERIC Educational Resources Information Center

Gottlieb, Nell H.

1983-01-01

Women attending four New England colleges were surveyed to determine how their health beliefs and attitudes related to smoking. Beliefs of current smokers, former smokers, and nonsmokers were explored in an effort to shed light on motivation. Implications for public policy are discussed. (PP)

Two-Part Tariff and Aftermarket Duopoly: An Illustration

ERIC Educational Resources Information Center

Felder, Joseph; Scott, Robert

2010-01-01

The authors shed light on the original equipment manufacturer's strategic behavior in the duopoly aftermarket. The original equipment manufacturer, firm 1, captures via its foremarket price some fraction of the aftermarket consumer surplus, where that surplus is generated by consumption of its own and its competitor's aftermarket products. The…

Brain Resilience: Shedding Light into the Black Box of Adventure Procesess

ERIC Educational Resources Information Center

Allan, John F.; McKenna, Jim; Hind, Karen

2012-01-01

Understanding of the active beneficial processes of adventure learning remains elusive. Resilience may provide one foundation for understanding the positive adaptation derived from Outdoor Adventure Education (OAE) and Adventure Therapy (AT) programming. From a neurological perspective, resilience may be explained by the brain's innate capability…

Language Management Agencies Counteracting Perceived Threats to Tradition

ERIC Educational Resources Information Center

Kristinsson, Ari Pall Kristinsson

2012-01-01

The article addresses the actual and perceived roles of national organisations and bodies, such as language "academies" or "councils", in recent history. In particular, the article seeks to shed light on the question what may prompt national governments in modernity and late modernity to establish and fund such bodies to…

Integration of Collaborative Learning in Grade K-5 EFL Classrooms

ERIC Educational Resources Information Center

Shahamat, Ailar; Mede, Enisa

2016-01-01

This study investigated the effectiveness of integrating collaborative learning in Turkish elementary (primary) classrooms where English is acquired as a foreign language. Specifically, it aimed at shedding light on how the participating students and teachers perceive such language classes, what are the effects of integrating this particular…

X-ray ptychography, fluorescence microscopy combo sheds new light on trace

Science.gov Websites

Research Divisions Computing, Environment and Life Sciences BIOBiosciences CPSComputational Science DSLData CEESCenter for Electrochemical Energy Science CTRCenter for Transportation Research CRIChain Reaction Navigation Toggle Search Energy Environment National Security User Facilities Science Work with Us About

"Ternura y tenacidad": "Testimonios" of Latina School Leaders

ERIC Educational Resources Information Center

Martinez, Melissa A.; Marquez, Jocabed; Cantú, Yvette; Rocha, Patricia A.

2016-01-01

This study utilized "testimonio" as method to unearth the voices of four Latina school leaders from the southern region of the U.S. to shed light on their experiences, including triumphs and struggles, in navigating their career trajectories. The "testimonios" revealed distinctions as well as commonalities among the Latina…

The Electrostatic Environments of Mars: Atmospheric Discharges

NASA Technical Reports Server (NTRS)

Calle, Carlos I.; Mackey, Paul J.; Johansen, Michael R.; Hogue, Michael D.; Phillips, James, III; Cox, Rachel E.

2016-01-01

The electrostatic environment on Mars is controlled by its ever present atmospheric dust. Dust devils and dust storms tribocharge this dust. Theoretical studies predict that lightning and/or glow discharges should be present on Mars, but none have been directly observed. Experiments are planned to shed light on this issue.

Low-Energy Cosmic Rays: Radiation Environment Studies and Astrophysics on the Deep Space Gateway

NASA Astrophysics Data System (ADS)

Losekamm, M. J.; Berger, T.

2018-02-01

The Deep Space Gateway will be ideally located to investigate the cosmic radiation that astronauts are subjected to in deep space and to help shed light on one of the most intriguing astrophysical mysteries of today: What is the universe made of?

Recasts, Field Dependence/Independence Cognitive Style, and L2 Development

ERIC Educational Resources Information Center

Rassaei, Ehsan

2015-01-01

While previous research has indicated that learners with field-dependence (FD) and field-independence (FI) cognitive styles benefit differentially from different instructional modes, previous corrective feedback studies have ignored the issue of matching error correction strategies to learners' cognitive style. To shed some light on this issue,…

Educational Affordances and Learning Design in Music Software Development

ERIC Educational Resources Information Center

Cheng, Lee; Leong, Samuel

2017-01-01

Although music software has become increasingly affordable and widely adopted in today's classrooms, concerns have been raised about a lack of consideration for users' needs during the software development process. This paper examines intra- and inter-sectoral communication pertaining to software development and music education to shed light on…

Facilitating North-South Partnerships for Sustainable Agriculture

ERIC Educational Resources Information Center

Termeer, C. J. A. M.; Hilhorst, T.; Oorthuizen, J.

2010-01-01

The increased number of development cooperation and sustainable agriculture partnerships brings with it new challenges for professionals who are asked to facilitate these partnering processes. In this article we shed more light on the world of development cooperation and we explore questions that facilitators working with North-South partnerships…

Language Distance Learning for the Digital Generation

ERIC Educational Resources Information Center

Duran-Cerda, Dolores

2010-01-01

The purpose of this article was to shed light on the potential of distance learning to overcome challenges in distance, space, time, and human and economic resources that limit access to language learning opportunities in cultural, literary, historical, geographical, and cross-cultural frames. Language and literature educators collectively have…

Art Portraying Medicine

ERIC Educational Resources Information Center

Koski, Kaisu

2011-01-01

A number of art projects are currently tackling the medical domain. This activity stems from a perceived need to increase the transparency and democracy of the medical domain, and it often questions the power relations and the one-dimensionality in current medical practices. This article sheds light on how artists process medical themes,…

A Self-Organizing Approach to Subject-Verb Number Agreement

ERIC Educational Resources Information Center

Smith, Garrett; Franck, Julie; Tabor, Whitney

2018-01-01

We present a self-organizing approach to sentence processing that sheds new light on notional plurality effects in agreement attraction, using pseudopartitive subject noun phrases (e.g., "a bottle of pills"). We first show that notional plurality ratings (numerosity judgments for subject noun phrases) predict verb agreement choices in…

On the Brink: Assessing the Status of the American Faculty

ERIC Educational Resources Information Center

Schuster, Jack H.; Finkelstein, Martin J.

2006-01-01

This essay outlines several themes that encapsulate the findings from the authors'--both professors of education--previously published study, "The American Faculty: The Restructuring of Academic Work and Careers," and sheds light on several areas that urgently need further probing. Suggestions for ensuring a productive future for the…

International Learning Adventures: A Phenomenological Exploration of International Backpacker Style Study Abroad

ERIC Educational Resources Information Center

Thatcher, Chad Alan

2010-01-01

Self-awareness, cultural competency, environmental consciousness, and economic empathy are often achieved through study abroad travel experiences. This phenomenological study was intended to shed light on the international backpacking study abroad experiences for college students, describing the phenomenon from the perspective of the participants…

Cross-Language Mediation in Foreign Language Teaching and Testing

ERIC Educational Resources Information Center

Stathopoulou, Maria

2015-01-01

This book contributes to the growing field of foreign language teaching and testing by shedding light on mediation between languages. Stathopoulou offers an empirically-grounded definition of mediation as a form of translanguaging and offers tools and methods for further research in multilingual testing. The book explores what cross-language…

Using Competencies to Improve School Turnaround Principal Success

ERIC Educational Resources Information Center

Steiner, Lucy; Hassel, Emily Ayscue

2011-01-01

This paper aims first to shed light on one element of leadership: the characteristics--or "competencies"--of turnaround leaders who succeed in driving rapid, dramatic change. Second, it recounts the elements of support that districts must provide these leaders to enable and sustain a portfolio of successful school turnarounds.…

Primary School Principals' Experiences with Smartphone Apps

ERIC Educational Resources Information Center

Çakir, Rahman; Aktay, Sayim

2016-01-01

Smartphones are not just pieces of hardware, they at same time also dip into software features such as communication systems. The aim of this study is to examine primary school principals' experiences with smart phone applications. Shedding light on this subject means that this research is qualitative. Criterion sampling has been intentionally…

GENERAL VIEW, LOOKING NORTH, OF ATOMIC PHYSICS OBSERVATORY WHICH CONTAINS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW, LOOKING NORTH, OF ATOMIC PHYSICS OBSERVATORY WHICH CONTAINS THE WHITE DOME STRUCTURE. THE SHED-LIKE STRUCTURE TO THE LEFT IS THE SEARCH-LIGHT BUILDING. - Carnegie Institution of Washington, Department of Terrestrial Magnetism, Atomic Physics Observatory, 5241 Broad Branch Drive Northwest, Washington, District of Columbia, DC

On cosmology in the laboratory.

PubMed

Leonhardt, Ulf

2015-08-28

In transformation optics, ideas from general relativity have been put to practical use for engineering problems. This article asks the question how this debt can be repaid. In discussing a series of recent laboratory experiments, it shows how insights from wave phenomena shed light on the quantum physics of the event horizon.

On Teaching the History and Philosophy of Geography.

ERIC Educational Resources Information Center

Meir, Avinoam

To shed light on the question of whether college geography students should be and/or are being instructed about the history and philosophy of geography, a survey was undertaken to determine the educational objectives and practices of geography educators. Approximately 215 American and Canadian geographic educators and chairpersons of geography…

Scholarly Communication in AERA Journals, 1931 to 2014

ERIC Educational Resources Information Center

Vanderstraeten, Raf; Vandermoere, Frédéric; Hermans, Maarten

2016-01-01

Scientific disciplines build on social structures, such as scholarly associations and scholarly journals, that facilitate the formation of communities of specialists. Analyses of such social structures can thus also be used to shed light on the morphogenesis of scientific specializations. The authors analyze how two journals of the American…

Toward a Science of Honors Education

ERIC Educational Resources Information Center

Jones, Beata M.

2016-01-01

In this article, Beata Jones attempts to organize the honors discipline into a comprehensive framework that can guide explorations and shed light on specific attributes of honors entities in the framework of their interrelationships. The framework offers an approach to deal with the inherent fragmentation of the field, which can lead to…

Highway to Space: The Direct Connection Between the Lower and the Upper Atmosphere of Mars Sheds a New Light on the History of Water

NASA Astrophysics Data System (ADS)

Montmessin, F.; Lefèvre, F.; Korablev, O.; Fedorova, A.; Bertaux, J.-L.; Chaufray, J.-Y.; Chaffin, M.; Schneider, N.; Maltagliati, L.; Määttänen, A.; Trokhimovsky, A.

2014-07-01

We present a synthesis of the decade-long Mars Express SPICAM observations in an attempt to assemble a single, coherent picture that has implications for the long-term evolution of water and hydrogen on Mars.

Educating the Next Generation: Improving Teacher Quality in Cambodia. Directions in Development

ERIC Educational Resources Information Center

Tandon, Prateek; Fukao, Tsuyoshi

2015-01-01

This book diagnoses Cambodian teaching quality and presents policy options for reform. Through classroom observation, assessments of mathematics and pedagogical content knowledge, and surveys of teachers and school directors, it sheds light on content and instruction, interactions with school directors, instructional support systems, and the…

A Sociolinguistic Study of Differential Object Marking (DOM) in Two Varieties of Contemporary Spanish

ERIC Educational Resources Information Center

Balasch Rodriguez, Sonia

2011-01-01

This sociolinguistic-variationist investigation sheds light on two little-studied issues concerning Spanish DOM, or variable use of a before animate "direct objects" (DOs), in vernacular language: the complex interaction of co-occurring linguistic (type of verb; definiteness, specificity, grammatical number, topicality, type and…

Relationships between Humor Styles and Family Functioning in Parents of Children with Disabilities

ERIC Educational Resources Information Center

Rieger, Alicja; McGrail, J. Patrick

2015-01-01

The humor styles and family functioning of parents of children with disabilities are understudied subjects. This study seeks to shed quantitative light on these areas. Seventy-two parents of children with disabilities completed the "Family Adaptability and Cohesion Evaluation Scales" (FACES IV) and the "Humor Styles…

Academic Engagement: An Overview of Its Definitions, Dimensions, and Major Conceptualisations

ERIC Educational Resources Information Center

Alrashidi, Oqab; Phan, Huy P.; Ngu, Bing H.

2016-01-01

Engagement is a prominent theoretical orientation that has received great attention from educators and researchers. This article provides a literature overview of the engagement construct pertaining to its various definitions, dimensions, and major conceptualisations. In addition, the review sheds light on two major approaches to engagement in the…

Engineering Lecturers' Views on CLIL and EMI

ERIC Educational Resources Information Center

Aguilar, Marta

2017-01-01

The present study aims to shed some light on how engineering lecturers teaching in English at a Spanish university view their work (teaching goals) within the current European internationalisation trend of offering courses and master programmes in English. A questionnaire where content and language integrated learning (CLIL) and English-medium…

Subtitling Television for Deaf Children. M.E.R.: No. 3.

ERIC Educational Resources Information Center

Baker, Robert

Experiments reported in this document were intended to shed light on the linguistic and presentational issues surrounding the provision of a subtitling service for deaf schoolchildren. A series of formal experiments was carried out to evaluate deaf children's appreciation of subtitled television programs. (These experiments are described in detail…

Melancholic Mothering: Mothers, Daughters and Family Violence

ERIC Educational Resources Information Center

Kenway, Jane; Fahey, Johannah

2008-01-01

Through selected theories of melancholia, this paper seeks to shed some fresh interpretive light on the reproduction and disruption of gender, violence and family turmoil across generations of mothers and daughters. The originality of the paper lies in its exploratory deployment of theories of melancholia to consider issues of women, violence and…

Phonological Memory and Rule Learning

ERIC Educational Resources Information Center

Williams, John N.; Lovatt, Peter

2005-01-01

Our research reflects the current trend to relate individual differences in second language learning to underlying cognitive processes e.g., Robinson, 2002. We believe that such investigations, apart from being of practical importance, can also shed light on the cognitive mechanisms underlying the language learning process. Here we focus on the…

Mining Social Media Data for Understanding Students' Learning Experiences

ERIC Educational Resources Information Center

Chen, Xin; Vorvoreanu, Mihaela; Madhavan, Krishna

2014-01-01

Students' informal conversations on social media (e.g., Twitter, Facebook) shed light into their educational experiences--opinions, feelings, and concerns about the learning process. Data from such uninstrumented environments can provide valuable knowledge to inform student learning. Analyzing such data, however, can be challenging. The complexity…

School Integration Matters: Research-Based Strategies to Advance Equity

ERIC Educational Resources Information Center

Frankenberg, Erica, Ed.; Garces, Liliana M., Ed.; Hopkins, Megan, Ed.

2016-01-01

More than 60 years after the "Brown v. Board of Education" decision declared segregated schooling inherently unequal, this timely book sheds light on how and why U.S. schools are experiencing increasing segregation along racial, socioeconomic, and linguistic lines. It offers policy and programmatic alternatives for advancing equity and…

The Problem with "Proficient"

ERIC Educational Resources Information Center

Harvey, James

2018-01-01

New research sheds light on the claim that U.S. students' achievement lags behind that of students worldwide. This research reveals a paradox: While large amounts of U.S. students who take the National Assessment of Educational Progress (NAEP) fail to meet its Proficient benchmarks in reading and math, when students' results on NAEP are…

Adult Students: Recruitment and Retention. Practice Application Brief No. 18.

ERIC Educational Resources Information Center

Wonacott, Michael E.

How to attract and retain adult students remains an enduring question for adult education providers. Recent research sheds light on adult learners' unique learning goals, needs, and aspirations and offers guidance on recruiting and retaining adult learners. Adult students' participation and persistence in educational activities is a complex…

Reconstructing the Theory-to-Practice Narrative

ERIC Educational Resources Information Center

Schulte, Julia

2013-01-01

Many teacher-development models posit teacher learning as a linear process in which teachers build skills and knowledge while progressing through different stages of expertise. Although this model is attractive for many reasons and often does seem to shed light on some of the aspects of teacher development, this author's own experience largely…

Thinking Conics

ERIC Educational Resources Information Center

Lewis, Richard

2008-01-01

For their course, mathematics students at Bath Spa University were asked to choose a topic and explore the mathematics. As well as learning some mathematics, the author hoped that the assignment would shed light on the process of mathematical investigation itself. Their course leader had suggested that the topic of conic sections was rich, and…

The Principalship in Developing Countries: Context, Characteristics and Reality

ERIC Educational Resources Information Center

Oplatka, Izhar

2004-01-01

This article seeks to shed light on the contexts and characteristics of principalship in developing countries, as well as to examine similarities and differences between principals in developed and developing countries. Twenty-seven papers constitute the data on which external influences on principalship, patterns of leadership styles and…

Understanding the mechanism of action of triazine-phosphonate derivatives as flame retardants for cotton fabrics

USDA-ARS?s Scientific Manuscript database

Countless hours of research and studies on triazine, phosphonate and their combination have provided insightful information into their flame retardant properties on polymeric systems. However, only limited number of studies shed light on the mechanism of flame retardant cotton fabrics. The purpose...

SLA and the Emergence of Creoles

ERIC Educational Resources Information Center

Mufwene, Salikoko S.

2010-01-01

Although the emergence of creoles presupposes naturalistic SLA, current SLA scholarship does not shed much light on the development of creoles with regard to the population-internal mechanisms that produce normalization and autonomization from the creoles' lexifiers. This is largely due to the fact that research on SLA is focused on individuals…

The Creative Process.

ERIC Educational Resources Information Center

Harjo, Joy; And Others

1985-01-01

Four Native American poets in easy narrative style tell about some of the aesthetic judgments they make in their work and, in the process, shed some light upon the traditions from which their poetry emerges. Joy Harjo discusses how she wrote "The Woman Hanging from the Thirteenth Floor Window," her use of repetition influenced by music…

The Predictive Validity of Projective Measures.

ERIC Educational Resources Information Center

Suinn, Richard M.; Oskamp, Stuart

Written for use by clinical practitioners as well as psychological researchers, this book surveys recent literature (1950-1965) on projective test validity by reviewing and critically evaluating studies which shed light on what may reliably be predicted from projective test results. Two major instruments are covered: the Rorschach and the Thematic…

Shedding Light on Shadow Education

ERIC Educational Resources Information Center

Kobakhidze, Magda Nutsa

2015-01-01

This essay review examines four different movies that directly or indirectly refer to the theme of private tutoring or, as it is widely called, shadow education. The movies, directed in locations as diverse as India, Turkey, and Cambodia, are all made from a critical perspective. The directors demonstrate challenges in public education systems and…

Latin American USOMs Seminar on Agrarian Reform.

ERIC Educational Resources Information Center

International Cooperation Administration (Dept. of State), Washington, DC.

This report of seminar proceedings discusses land reform policies and programs and their place in the economic development of Latin America. It analyzes experiences and current situations in Latin America, the United States, and elsewhere which shed light on the problems and possibilities of agrarian reform. An appraisal of existing physical,…

Selectivity in Toddlers' Behavioral and Emotional Reactions to Prosocial and Antisocial Others

ERIC Educational Resources Information Center

Van de Vondervoort, Julia W.; Aknin, Lara B.; Kushnir, Tamar; Slevinsky, Janine; Hamlin, J. Kiley

2018-01-01

Whereas some evidence suggests that toddlers consider targets' deservingness when deciding whom to help, other research demonstrates that toddlers help indiscriminately. The present findings shed light on this discrepancy by demonstrating that although toddlers do exhibit selectivity in giving behaviors, their emotional responses are comparatively…

Higher Education Research Digest

ERIC Educational Resources Information Center

ACT, Inc., 2017

2017-01-01

This new ACT publication is an annual report offering meaningful research insights for some of the most pressing questions impacting admissions and enrollment practice. In the first release of this report, ACT research sheds light on the following topics: (1) the practice of super-scoring; (2) STEM major choice; (3) factors impacting retention and…

Overcoming Pedagogical Solitude: The Transformative Power of Discipline-Specific Faculty Learning Communities

ERIC Educational Resources Information Center

Tovar, Mariela; Jukier, Rosalie; Ferris, Jennie; Cardoso, Kristen

2015-01-01

This article describes a multiyear Faculty Learning Community (FLC) program as a strategy to overcome pedagogical solitude (Shulman, 1993) in a discipline-specific context. Participant interviews shed light on their FLC experiences and perceived impact on their teaching and students' learning. Grounded within the particularities of the…

Technology Leadership in Saudi Schools

ERIC Educational Resources Information Center

Alenezi, Abdullah

2017-01-01

This paper demonstrates the potential of Saudi schools for technology leadership provided by Learning Resource Centres (LRCs) to enhance the formation of a technology-motivated educational environment. Using the grounded theory methodology and the CBAM stages of concern and levels of use this study sheds light on Saudi LRCs and their leadership…

Christopher Columbus and Early Americans Booklist.

ERIC Educational Resources Information Center

Misheff, Sue

1992-01-01

Presents brief descriptions of 31 books (published between 1962 and 1991) concerning the commemoration of the discovery of the Americas. Divides the books into those about Christopher Columbus, those that shed light on the world in which he lived, and those that look at the Americas before he landed. (RS)

"Red Eyes": Engaging Emotions in Multicultural Education

ERIC Educational Resources Information Center

Wang, Hongyu

2008-01-01

Engaging emotions in multicultural education is an important but a relatively neglected issue in teacher education. This essay calls for pedagogical attention to the role of emotions and attempts to analyze how teaching autobiographies and films sheds light on the emotional dynamics of multicultural education. Two films, "The Color of Fear", and…

Education for Strategic Environmental Behavior

ERIC Educational Resources Information Center

Chawla, Louise; Cushing, Debra Flanders

2007-01-01

This article reviews four bodies of research that shed light on how to promote active care for the environment in children and youth: research on sources of proenvironmental behavior, socialization for democratic skills and values, the development of a personal sense of competence, and the development of collective competence. The article begins…

Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute lung injury in mice.

PubMed

Wakayama, Hirotaka; Hashimoto, Naozumi; Matsushita, Yoshihiro; Matsubara, Kohki; Yamamoto, Noriyuki; Hasegawa, Yoshinori; Ueda, Minoru; Yamamoto, Akihito

2015-08-01

Acute respiratory distress syndrome (ARDS) is a severe inflammatory disorder characterized by acute respiratory failure, resulting from severe, destructive lung inflammation and irreversible lung fibrosis. We evaluated the use of stem cells derived from human exfoliated deciduous teeth (SHEDs) or SHED-derived serum-free conditioned medium (SHED-CM) as treatments for bleomycin (BLM)-induced mice acute lung injury (ALI), exhibiting several pathogenic features associated with the human disease ARDS. Mice with BLM-induced ALI with or without SHED or SHED-CM treatment were examined for weight loss and survival. The lung tissue was characterized by histological and real-time quantitative polymerase chain reaction analysis. The effects of SHED-CM on macrophage differentiation in vitro were also assessed. A single intravenous administration of either SHEDs or SHED-CM attenuated the lung injury and weight loss in BLM-treated mice and improved their survival rate. Similar recovery levels were seen in the SHEDs and SHED-CM treatment groups, suggesting that SHED improves ALI by paracrine mechanisms. SHED-CM contained multiple therapeutic factors involved in lung-regenerative mechanisms. Importantly, SHED-CM attenuated the BLM-induced pro-inflammatory response and generated an anti-inflammatory/tissue-regenerating environment, accompanied by the induction of anti-inflammatory M2-like lung macrophages. Furthermore, SHED-CM promoted the in vitro differentiation of bone marrow-derived macrophages into M2-like cells, which expressed high levels of Arginase1, CD206 and Ym-1. Our results suggest that SHED-secreted factors provide multifaceted therapeutic effects, including a strong M2-inducing activity, for treating BLM-induced ALI. This work may open new avenues for research on stem cell-based ARDS therapies. Copyright © 2015 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Morintides: cargo-free chitin-binding peptides from Moringa oleifera.

PubMed

Kini, Shruthi G; Wong, Ka H; Tan, Wei Liang; Xiao, Tianshu; Tam, James P

2017-03-31

Hevein-like peptides are a family of cysteine-rich and chitin-binding peptides consisting of 29-45 amino acids. Their chitin-binding property is essential for plant defense against fungi. Based on the number of cysteine residues in their sequences, they are divided into three sub-families: 6C-, 8C- and 10C-hevein-like peptides. All three subfamilies contain a three-domain precursor comprising a signal peptide, a mature hevein-like peptide and a C-terminal domain comprising a hinge region with protein cargo in 8C- and 10C-hevein-like peptides. Here we report the isolation and characterization of two novel 8C-hevein-like peptides, designated morintides (mO1 and mO2), from the drumstick tree Moringa oleifera, a drought-resistant tree belonging to the Moringaceae family. Proteomic analysis revealed that morintides comprise 44 amino acid residues and are rich in cysteine, glycine and hydrophilic amino acid residues such as asparagine and glutamine. Morintides are resistant to thermal and enzymatic degradation, able to bind to chitin and inhibit the growth of phyto-pathogenic fungi. Transcriptomic analysis showed that they contain a three-domain precursor comprising an endoplasmic reticulum (ER) signal sequence, a mature peptide domain and a C-terminal domain. A striking feature distinguishing morintides from other 8C-hevein-like peptides is a short and protein-cargo-free C-terminal domain. Previously, a similar protein-cargo-free C-terminal domain has been observed only in ginkgotides, the 8C-hevein-like peptides from a gymnosperm Ginkgo biloba. Thus, morintides, with a cargo-free C-terminal domain, are a stand-alone class of 8C-hevein-like peptides from angiosperms. Our results expand the existing library of hevein-like peptides and shed light on molecular diversity within the hevein-like peptide family. Our work also sheds light on the anti-fungal activity and stability of 8C-hevein-like peptides.

Anadromous salmonids in the Delta: New science 2006–2016

USGS Publications Warehouse

Perry, Russell W.; Buchanan, Rebecca A.; Brandes, Patricia L.; Burau, Jon R.; Israel, Joshua A

2016-01-01

As juvenile salmon enter the Sacramento–SanJoaquin River Delta (“the Delta”) they disperse among its complex channel network where they are subject to channel-specific processes that affect their rate of migration, vulnerability to predation, feeding success, growth rates, and ultimately, survival. In the decades before 2006, tools available to quantify growth, dispersal, and survival of juvenile salmon in this complex channel network were limited.Fortunately, thanks to technological advances such as acoustic telemetry and chemical and structural otolith analysis, much has been learned over the past decade about the role of the Delta in the life cycle of juvenile salmon. Here, we review new science between 2006and 2016 that sheds light on how different life stages and runs of juvenile salmon grow, move, and survive in the complex channel network of the Delta. One of the most important advances during the past decade has been the widespread adoption of acoustic telemetry techniques. Use of telemetry has shed light on how survival varies among alternative migration routes and the proportion of fish that use each migration route. Chemical and structural analysis of otoliths has provided insights about when juveniles left their natal river and provided evidence of extended rearing in the brackish or saltwater regions of the Delta. New advancements in genetics now allow individuals captured by trawls to be assigned to specific runs. Detailed information about movement and survival in the Delta has spurred development of agent-based models of juvenile salmon that are coupled to hydrodynamic models. Although much has been learned, knowledge gaps remain about how very small juvenile salmon (fry and parr) use the Delta. Understanding how all life stages of juvenile salmon grow, rear, and survive in the Delta is critical for devising management strategies that support a diversity of life history strategies.

Shedding Light on Nanomedicine

PubMed Central

Tong, Rong

2012-01-01

Light is electromagnetic radiation that can convert its energy into different forms (e.g., heat, chemical energy, and acoustic waves). This property has been exploited in phototherapy (e.g., photothermal therapy and photodynamic therapy) and optical imaging (e.g., fluorescence imaging) for therapeutic and diagnostic purposes. Light-controlled therapies can provide minimally or non-invasive spatiotemporal control as well as deep tissue penetration. Nanotechnology provides a numerous advantages, including selective targeting of tissues, prolongation of therapeutic effect, protection of active payloads, and improved therapeutic indices. This review explores the advances that nanotechnology can bring to light-based therapies and diagnostics, and vice versa, including photo-triggered systems, nanoparticles containing photoactive molecules, and nanoparticles that are themselves photoactive. Limitations of light-based therapies such as photic injury and phototoxicity will be discussed. PMID:22887840

An impact analysis of a flexible bat using an iterative solver.

PubMed

Penrose, J M; Hose, D R

1999-08-01

Although technology has now infiltrated and prompted evolution in most mass participation sports, the advances in bat technology in such sports as baseball and cricket have been relatively minor. In this study, we used a simple finite element modelling approach to try to shed new light upon the underlying mechanics of the bat-ball impact, with a view to the future optimization of bat design. The analysis of a flexible bat showed that the point of impact that produced the maximum post-impact ball velocity was a function of the bat's vibrational properties and was not necessarily at the centre of percussion. The details of the analysis agreed well with traditional Hertzian impact theory, and broadly with empirical data. An inspection of the relative modal contributions to the deformations during impact also showed that the position of the node of the first flexure mode was important. In conclusion, considerable importance should be attached to the bat's vibrational properties in future design and analysis.

Using aggregate data to estimate the standard error of a treatment-covariate interaction in an individual patient data meta-analysis.

PubMed

Kovalchik, Stephanie A; Cumberland, William G

2012-05-01

Subgroup analyses are important to medical research because they shed light on the heterogeneity of treatment effectts. A treatment-covariate interaction in an individual patient data (IPD) meta-analysis is the most reliable means to estimate how a subgroup factor modifies a treatment's effectiveness. However, owing to the challenges in collecting participant data, an approach based on aggregate data might be the only option. In these circumstances, it would be useful to assess the relative efficiency and power loss of a subgroup analysis without patient-level data. We present methods that use aggregate data to estimate the standard error of an IPD meta-analysis' treatment-covariate interaction for regression models of a continuous or dichotomous patient outcome. Numerical studies indicate that the estimators have good accuracy. An application to a previously published meta-regression illustrates the practical utility of the methodology. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Detecting intrinsic dynamics of traffic flow with recurrence analysis and empirical mode decomposition

NASA Astrophysics Data System (ADS)

Xiong, Hui; Shang, Pengjian; Bian, Songhan

2017-05-01

In this paper, we apply the empirical mode decomposition (EMD) method to the recurrence plot (RP) and recurrence quantification analysis (RQA), to evaluate the frequency- and time-evolving dynamics of the traffic flow. Based on the cumulative intrinsic mode functions extracted by the EMD, the frequency-evolving RP regarding different oscillation of modes suggests that apparent dynamics of the data considered are mainly dominated by its components of medium- and low-frequencies while severely affected by fast oscillated noises contained in the signal. Noises are then eliminated to analyze the intrinsic dynamics and consequently, the denoised time-evolving RQA diversely characterizes the properties of the signal and marks crucial points more accurately where white bands in the RP occur, whereas a strongly qualitative agreement exists between all the non-denoised RQA measures. Generally, the EMD combining with the recurrence analysis sheds more reliable, abundant and inherent lights into the traffic flow, which is meaningful to the empirical analysis of complex systems.

Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo.

PubMed

Mao, Yingyu; Finnemann, Silvia C

2016-01-01

Renewal of rod photoreceptor outer segments in the mammalian eye involves synchronized diurnal shedding after light onset of spent distal outer segment fragments (POS) linked to swift clearance of shed POS from the subretinal space by the adjacent retinal pigment epithelium (RPE). Engulfed POS phagosomes in RPE cells mature to acidified phagolysosomes, which accomplish enzymatic degradation of POS macromolecules. Here, we used an acidophilic fluorophore LysoTracker to label acidic organelles in freshly dissected, live rat RPE tissue flat mounts. We observed that all RPE cells imaged contained numerous acidified POS phagolysosomes whose abundance per cell was dramatically increased 2 h after light onset as compared to either 1 h before or 4 h after light onset. Lack of organelles of similar diameter (of 1-2 μm) in phagocytosis-defective mutant RCS rat RPE confirmed that LysoTracker live imaging detected POS phagolysosomes. Lack of increase in lysosomal membrane protein LAMP-1 in RPE/choroid during the diurnal phagocytic burst suggests that formation of POS phagolysosomes in RPE in situ may not involve extra lysosome membrane biogenesis. Taken together, we report a new imaging approach that directly detects POS phagosome acidification and allows rapid tracking and quantification of POS phagocytosis by live RPE -tissue ex situ.

Structured literature review of responses of cattle to viral and bacterial pathogens causing bovine respiratory disease complex.

PubMed

Grissett, G P; White, B J; Larson, R L

2015-01-01

Bovine respiratory disease (BRD) is an economically important disease of cattle and continues to be an intensely studied topic. However, literature summarizing the time between pathogen exposure and clinical signs, shedding, and seroconversion is minimal. A structured literature review of the published literature was performed to determine cattle responses (time from pathogen exposure to clinical signs, shedding, and seroconversion) in challenge models using common BRD viral and bacterial pathogens. After review a descriptive analysis of published studies using common BRD pathogen challenge studies was performed. Inclusion criteria were single pathogen challenge studies with no treatment or vaccination evaluating outcomes of interest: clinical signs, shedding, and seroconversion. Pathogens of interest included: bovine viral diarrhea virus (BVDV), bovine herpesvirus type 1 (BHV-1), parainfluenza-3 virus, bovine respiratory syncytial virus, Mannheimia haemolytica, Mycoplasma bovis, Pastuerella multocida, and Histophilus somni. Thirty-five studies and 64 trials were included for analysis. The median days to the resolution of clinical signs after BVDV challenge was 15 and shedding was not detected on day 12 postchallenge. Resolution of BHV-1 shedding resolved on day 12 and clinical signs on day 12 postchallenge. Bovine respiratory syncytial virus ceased shedding on day 9 and median time to resolution of clinical signs was on day 12 postchallenge. M. haemolytica resolved clinical signs 8 days postchallenge. This literature review and descriptive analysis can serve as a resource to assist in designing challenge model studies and potentially aid in estimation of duration of clinical disease and shedding after natural pathogen exposure. Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

A proteorhodopsin-based biohybrid light-powering pH sensor.

PubMed

Rao, Siyuan; Guo, Zhibin; Liang, Dawei; Chen, Deliang; Wei, Yen; Xiang, Yan

2013-10-14

The biohybrid sensor is an emerging technique for multi-functional detection that utilizes the instinctive responses or interactions of biomolecules. We develop a biohybrid pH sensor by taking advantage of the pH-dependent photoelectric characteristics of proteorhodopsin (pR). The transient absorption kinetics study indicates that the photoelectric behavior of pR is attributed to the varying lifetime of the M intermediate at different environmental pH values. This pR-based biohybrid light-powering sensor with microfluidic design can achieve real-time pH detection with quick response and high sensitivity. The results of this work would shed light on pR and its potential applications.

Deciphering the Magainin Resistance Process of Escherichia coli Strains in Light of the Cytosolic Proteome

PubMed Central

Maria-Neto, Simone; Cândido, Elizabete de Souza; Rodrigues, Diana Ribas; de Sousa, Daniel Amaro; da Silva, Ezequiel Marcelino; de Moraes, Lidia Maria Pepe; Otero-Gonzalez, Anselmo de Jesus; Magalhães, Beatriz Simas; Dias, Simoni Campos

2012-01-01

Antimicrobial peptides (AMPs) are effective antibiotic agents commonly found in plants, animals, and microorganisms, and they have been suggested as the future of antimicrobial chemotherapies. It is vital to understand the molecular details that define the mechanism of action of resistance to AMPs for a rational planning of the next antibiotic generation and also to shed some light on the complex AMP mechanism of action. Here, the antibiotic resistance of Escherichia coli ATCC 8739 to magainin I was evaluated in the cytosolic subproteome. Magainin-resistant strains were selected after 10 subsequent spreads at subinhibitory concentrations of magainin I (37.5 mg · liter−1), and their cytosolic proteomes were further compared to those of magainin-susceptible strains through two-dimensional electrophoresis analysis. As a result, 41 differentially expressed proteins were detected by in silico analysis and further identified by tandem mass spectrometry de novo sequencing. Functional categorization indicated an intense metabolic response mainly in energy and nitrogen uptake, stress response, amino acid conversion, and cell wall thickness. Indeed, data reported here show that resistance to cationic antimicrobial peptides possesses a greater molecular complexity than previously supposed, resulting in cell commitment to several metabolic pathways. PMID:22290970

A novel computational approach for simultaneous tracking and feature extraction of C. elegans populations in fluid environments.

PubMed

Tsechpenakis, Gabriel; Bianchi, Laura; Metaxas, Dimitris; Driscoll, Monica

2008-05-01

The nematode Caenorhabditis elegans (C. elegans) is a genetic model widely used to dissect conserved basic biological mechanisms of development and nervous system function. C. elegans locomotion is under complex neuronal regulation and is impacted by genetic and environmental factors; thus, its analysis is expected to shed light on how genetic, environmental, and pathophysiological processes control behavior. To date, computer-based approaches have been used for analysis of C. elegans locomotion; however, none of these is both high resolution and high throughput. We used computer vision methods to develop a novel automated approach for analyzing the C. elegans locomotion. Our method provides information on the position, trajectory, and body shape during locomotion and is designed to efficiently track multiple animals (C. elegans) in cluttered images and under lighting variations. We used this method to describe in detail C. elegans movement in liquid for the first time and to analyze six unc-8, one mec-4, and one odr-1 mutants. We report features of nematode swimming not previously noted and show that our method detects differences in the swimming profile of mutants that appear at first glance similar.

Comparative characterization of stem cells from human exfoliated deciduous teeth, dental pulp, and bone marrow-derived mesenchymal stem cells.

PubMed

Kunimatsu, Ryo; Nakajima, Kengo; Awada, Tetsuya; Tsuka, Yuji; Abe, Takaharu; Ando, Kazuyo; Hiraki, Tomoka; Kimura, Aya; Tanimoto, Kotaro

2018-06-18

Mesenchymal stem cells (MSCs) are used clinically in tissue engineering and regenerative medicine. The proliferation and osteogenic differentiation potential of MSCs vary according to factors such as tissue source and cell population heterogeneity. Dental tissue has received attention as an easily accessible source of high-quality stem cells. In this study, we compared the in vitro characteristics of dental pulp stem cells from deciduous teeth (SHED), human dental pulp stem cells (hDPSCs), and human bone marrow mesenchymal stem cells (hBMSCs). SEHD and hDPSCs were isolated from dental pulp and analyzed in comparison with human bone marrow (hBM)MSCs. Proliferative capacity of cultured cells was analyzed using a bromodeoxyuridine immunoassay and cell counting. Alkaline phosphatase (ALP) levels were monitored to assess osteogenic differentiation. Mineralization was evaluated by alizarin red staining. Levels of bone marker mRNA were examined by real-time PCR analysis. SHED were highly proliferative compared with hDPSCs and hBMSCs. SHED, hDPSCs, and hBMSCs exhibited dark alizarin red staining on day 21 after induction of osteogenic differentiation, and staining of hBMSCs was significantly higher than that of SHED and hDPSCs by spectrophotometry. ALP staining was stronger in hBMSCs compared with SHED and hDPSCs, and ALP activity was significantly higher in hBMSCs compared with SHED or hDPSCs. SHED showed significantly higher expression of the Runx2 and ALP genes compared with hBMSCs, based on real-time PCR analysis. In bFGF, SHED showed significantly higher expression of the basic fibroblast growth factor (bFGF) gene compared with hDPSCs and hBMSCs. SHED exhibited higher proliferative activity and levels of bFGF and BMP-2 gene expression compared with BMMSCs and DPSCs. The ease of harvesting cells and ability to avoid invasive surgical procedures suggest that SHED may be a useful cell source for application in bone regeneration treatments. Copyright © 2018 Elsevier Inc. All rights reserved.

Retinal transcriptome sequencing sheds light on the adaptation to nocturnal and diurnal lifestyles in raptors.

PubMed

Wu, Yonghua; Hadly, Elizabeth A; Teng, Wenjia; Hao, Yuyang; Liang, Wei; Liu, Yu; Wang, Haitao

2016-09-20

Owls (Strigiformes) represent a fascinating group of birds that are the ecological night-time counterparts to diurnal raptors (Accipitriformes). The nocturnality of owls, unusual within birds, has favored an exceptional visual system that is highly tuned for hunting at night, yet the molecular basis for this adaptation is lacking. Here, using a comparative evolutionary analysis of 120 vision genes obtained by retinal transcriptome sequencing, we found strong positive selection for low-light vision genes in owls, which contributes to their remarkable nocturnal vision. Not surprisingly, we detected gene loss of the violet/ultraviolet-sensitive opsin (SWS1) in all owls we studied, but two other color vision genes, the red-sensitive LWS and the blue-sensitive SWS2, were found to be under strong positive selection, which may be linked to the spectral tunings of these genes toward maximizing photon absorption in crepuscular conditions. We also detected the only other positively selected genes associated with motion detection in falcons and positively selected genes associated with bright-light vision and eye protection in other diurnal raptors (Accipitriformes). Our results suggest the adaptive evolution of vision genes reflect differentiated activity time and distinct hunting behaviors.

Initial sequence and comparative analysis of the cat genome

PubMed Central

Pontius, Joan U.; Mullikin, James C.; Smith, Douglas R.; Lindblad-Toh, Kerstin; Gnerre, Sante; Clamp, Michele; Chang, Jean; Stephens, Robert; Neelam, Beena; Volfovsky, Natalia; Schäffer, Alejandro A.; Agarwala, Richa; Narfström, Kristina; Murphy, William J.; Giger, Urs; Roca, Alfred L.; Antunes, Agostinho; Menotti-Raymond, Marilyn; Yuhki, Naoya; Pecon-Slattery, Jill; Johnson, Warren E.; Bourque, Guillaume; Tesler, Glenn; O’Brien, Stephen J.

2007-01-01

The genome sequence (1.9-fold coverage) of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals (human, chimpanzee, mouse, rat, dog, and cow). The results resolved chromosomal positions for 663,480 contigs, 20,285 putative feline gene orthologs, and 133,499 conserved sequence blocks (CSBs). Additional annotated features include repetitive elements, endogenous retroviral sequences, nuclear mitochondrial (numt) sequences, micro-RNAs, and evolutionary breakpoints that suggest historic balancing of translocation and inversion incidences in distinct mammalian lineages. Large numbers of single nucleotide polymorphisms (SNPs), deletion insertion polymorphisms (DIPs), and short tandem repeats (STRs), suitable for linkage or association studies were characterized in the context of long stretches of chromosome homozygosity. In spite of the light coverage capturing ∼65% of euchromatin sequence from the cat genome, these comparative insights shed new light on the tempo and mode of gene/genome evolution in mammals, promise several research applications for the cat, and also illustrate that a comparative approach using more deeply covered mammals provides an informative, preliminary annotation of a light (1.9-fold) coverage mammal genome sequence. PMID:17975172

Retinal transcriptome sequencing sheds light on the adaptation to nocturnal and diurnal lifestyles in raptors

PubMed Central

Wu, Yonghua; Hadly, Elizabeth A.; Teng, Wenjia; Hao, Yuyang; Liang, Wei; Liu, Yu; Wang, Haitao

2016-01-01

Owls (Strigiformes) represent a fascinating group of birds that are the ecological night-time counterparts to diurnal raptors (Accipitriformes). The nocturnality of owls, unusual within birds, has favored an exceptional visual system that is highly tuned for hunting at night, yet the molecular basis for this adaptation is lacking. Here, using a comparative evolutionary analysis of 120 vision genes obtained by retinal transcriptome sequencing, we found strong positive selection for low-light vision genes in owls, which contributes to their remarkable nocturnal vision. Not surprisingly, we detected gene loss of the violet/ultraviolet-sensitive opsin (SWS1) in all owls we studied, but two other color vision genes, the red-sensitive LWS and the blue-sensitive SWS2, were found to be under strong positive selection, which may be linked to the spectral tunings of these genes toward maximizing photon absorption in crepuscular conditions. We also detected the only other positively selected genes associated with motion detection in falcons and positively selected genes associated with bright-light vision and eye protection in other diurnal raptors (Accipitriformes). Our results suggest the adaptive evolution of vision genes reflect differentiated activity time and distinct hunting behaviors. PMID:27645106

Imaging galectin-3 dependent endocytosis with lattice light-sheet microscopy

NASA Astrophysics Data System (ADS)

Baek, Jongho; Lou, Jieqiong; Coelho, Simao; Lim, Yean Jin; Seidlitz, Silvia; Nicovich, Philip R.; Wunder, Christian; Johannes, Ludger; Gaus, Katharina

2017-04-01

Lattice light-sheet (LLS) microscopy provides ultrathin light sheets of a two-dimensional optical lattice that allows us imaging three-dimensional (3D) objects for hundreds of time points at sub-second intervals and at or below the diffraction limit. Galectin-3 (Gal3), a carbohydrate-binding protein, triggers glycosphingolipid (GSL)-dependent biogenesis of morphologically distinct endocytic vesicles that are cargo specific and clathrin independent. In this study, we apply LLS microscopy to study the dynamics of Gal3 dependent endocytosis in live T cells. This will allow us to observe Gal3-mediated endocytosis at high temporal and excellent 3D spatial resolution, which may shed light on our understanding of the mechanism and physiological function of Gal3-induced endocytosis.

Immunomodulatory Role of Stem Cells from Human Exfoliated Deciduous Teeth on Periodontal Regeneration.

PubMed

Gao, Xianling; Shen, Zongshan; Guan, Meiliang; Huang, Qiting; Chen, Lingling; Qin, Wei; Ge, Xiaohu; Chen, Haijia; Xiao, Yin; Lin, Zhengmei

2018-05-09

Periodontitis is initiated by the infection of periodontal bacteria and subsequent tissue inflammation due to immunoreaction, eventually leading to periodontal apparatus loss. Stem cells from human exfoliated deciduous teeth (SHEDs) have exhibited beneficial characteristics in dental tissue regeneration. However, the immunomodulatory functions of SHEDs have not been elucidated in the context of periodontitis treatment. In this study, we investigated the potential immunomodulatory effects of SHEDs on experimental periodontitis and demonstrated that multidose delivery of SHEDs led to periodontal tissue regeneration. SHEDs and monocytes/macrophages were cocultured in transwell systems and SHEDs were found to be capable of promoting monocyte/macrophage conversion to CD206 + M2-like phenotype. Bioluminescence imaging (BLI) was employed to assess the survival and distribution of SHEDs after delivery in periodontal tissues in an induced periodontitis model, and BLI revealed that SHEDs survived for ∼7 days in periodontal tissues with little tissue diffusion. Then, multidose SHED delivery was applied to treat periodontitis at 7-day intervals. Results showed that mutidose SHEDs altered the cytokine expression profile in gingival crevicular fluid, reduced gum bleeding, increased new attachment of periodontal ligament, and decreased osteoclast differentiation. Micro-computed tomography analysis showed SHED administration significantly increased periodontal regeneration and alveolar bone volume, and decreased distance of cementoenamel junction to alveolar bone crest. Furthermore, an increase in the number of CD206 + M2 macrophages was observed in periodontal tissues following the delivery of SHEDs, which aligned well with the promoted conversion to CD206 + M2-like cells from monocytes/macrophages in vitro after stimulation by SHEDs. This study demonstrated in a rat periodontitis model that local delivery of SHEDs attributed to the induction of M2 macrophage polarization, reduction of periodontal tissue inflammation, and enhancement of periodontal regeneration.

A Study on a Centralized Under-Voltage Load Shedding Scheme Considering the Load Characteristics

NASA Astrophysics Data System (ADS)

Deng, Jiyu; Liu, Junyong

Under-voltage load shedding is an important measure for maintaining voltage stability.Aiming at the optimal load shedding problem considering the load characteristics,firstly,the traditional under-voltage load shedding scheme based on a static load model may cause the analysis inaccurate is pointed out on the equivalent Thevenin circuit.Then,the dynamic voltage stability margin indicator is derived through local measurement.The derived indicator can reflect the voltage change of the key area in a myopia linear way.Dimensions of the optimal problem will be greatly simplified using this indicator.In the end,mathematical model of the centralized load shedding scheme is built with the indicator considering load characteristics.HSPPSO is introduced to slove the optimal problem.Simulation results on IEEE-39 system show that the proposed scheme display a good adaptability in solving the under-voltage load shedding considering dynamic load characteristics.

Transplantation of stem cells from human exfoliated deciduous teeth for bone regeneration in the dog mandibular defect

PubMed Central

Behnia, Ali; Haghighat, Abbas; Talebi, Ardeshir; Nourbakhsh, Nosrat; Heidari, Fariba

2014-01-01

AIM: To investigate the effect of stem cells from human exfoliated deciduous teeth (SHED) transplanted for bone regeneration in the dog mandibular defect. METHODS: In this prospective comparative study, SHEDs had been isolated 5 years ago from human exfoliated deciduous teeth. The undifferentiated stem cells were seeded into mandibular bone through-and-through defects of 4 dogs. Similar defects in control group were filled with cell-free collagen scaffold. After 12 wk, biopsies were taken and morphometric analysis was performed. The percentage of new bone formation and foreign body reaction were measured in each case. The data were subject to statistical analysis using the Mann-Whitney U and Kruskalwalis statistical tests. Differences at P < 0.05 was considered as significant level. RESULTS: There were no significant differences between control and SHED-seeded groups in connective tissue (P = 0.248), woven bone (P = 0.248) and compact bone (P = 0.082). There were not any side effects in transplanted SHED group such as teratoma or malignancy and abnormalities in this period. CONCLUSION: SHEDs which had been isolated and characterized 5 years ago and stored with cryopreservation banking were capable of proliferation and osteogenesis after 5 years, and no immune response was observed after three months of seeded SHEDs. PMID:25258673

[I don't want to be eternally imprisoned in the cage of my own self . . .". assumptions about the relationship between Sigmund Freud and his juvenile patient Arthur Fischer-Colbrie (1895-1968)].

PubMed

Walder, Christine

2010-01-01

The Austrian writer A. Fischer-Colbrie underwent an analysis with Freud in 1915-16 and then again in 1919. Based on his literary estate, this article tries to shed some light on the biographical background and the precipitating factors of his mental problems. When the cure had to be interrupted because of the young man's military service, Freud sustained an unusual correspondence with him that reflected his efforts to maintain their therapeutic contact. At the same time his letters witness Fischer-Colbrie's burgeoning literary talents.--An appendix presents Freud's letters to Fischer-Colbrie, edited and annotated by Michael Schröter.

Genetic and genomic glimpses of the elusive arbuscular mycorrhizal fungi.

PubMed

Lanfranco, Luisa; Young, J Peter W

2012-08-01

Arbuscular mycorrhizal fungi (AMF), which form an ancient and widespread mutualistic symbiosis with plants, are a crucial but still enigmatic component of the plant microbiome. Nowadays, their obligate biotrophy is no longer an obstacle to deciphering the role played by AMF in this fascinating symbiosis. The first genome-wide transcriptomic analysis of an AMF showed a metabolic complexity with no sign of massive gene loss, and the presence of genes for meiotic recombination suggests that AMF are not simple clonal organisms, as originally thought. New findings on suppression of host defenses and nutrient exchange processes have shed light on the mechanisms that contribute to such an intimate and long-lasting integration between living plant and fungal cells. Copyright © 2012 Elsevier Ltd. All rights reserved.

Ultraconfined Plasmonic Hotspots Inside Graphene Nanobubbles.

PubMed

Fei, Z; Foley, J J; Gannett, W; Liu, M K; Dai, S; Ni, G X; Zettl, A; Fogler, M M; Wiederrecht, G P; Gray, S K; Basov, D N

2016-12-14

We report on a nanoinfrared (IR) imaging study of ultraconfined plasmonic hotspots inside graphene nanobubbles formed in graphene/hexagonal boron nitride (hBN) heterostructures. The volume of these plasmonic hotspots is more than one-million-times smaller than what could be achieved by free-space IR photons, and their real-space distributions are controlled by the sizes and shapes of the nanobubbles. Theoretical analysis indicates that the observed plasmonic hotspots are formed due to a significant increase of the local plasmon wavelength in the nanobubble regions. Such an increase is attributed to the high sensitivity of graphene plasmons to its dielectric environment. Our work presents a novel scheme for plasmonic hotspot formation and sheds light on future applications of graphene nanobubbles for plasmon-enhanced IR spectroscopy.

Time-resolved structural studies at synchrotrons and X-ray free electron lasers: opportunities and challenges

PubMed Central

Neutze, Richard; Moffat, Keith

2012-01-01

X-ray free electron lasers (XFELs) are potentially revolutionary X-ray sources because of their very short pulse duration, extreme peak brilliance and high spatial coherence, features that distinguish them from today’s synchrotron sources. We review recent time-resolved Laue diffraction and time-resolved wide angle X-ray scattering (WAXS) studies at synchrotron sources, and initial static studies at XFELs. XFELs have the potential to transform the field of time-resolved structural biology, yet many challenges arise in devising and adapting hardware, experimental design and data analysis strategies to exploit their unusual properties. Despite these challenges, we are confident that XFEL sources are poised to shed new light on ultrafast protein reaction dynamics. PMID:23021004

GFP tagging sheds light on protein translocation: implications for key methods in cell biology.

PubMed

Deponte, Marcel

2012-04-01

Green fluorescent protein (GFP) is a powerful tool for studying gene expression, protein localization, protein-protein interactions, calcium concentrations, and redox potentials owing to its intrinsic fluorescence. However, GFP not only contains a chromophore but is also tightly folded in a temperature-dependent manner. The latter property of GFP has recently been exploited (1) to characterize the translocase of the outer mitochondrial membrane and (2) to discriminate between protein transport across and into biomembranes in vivo. I therefore suggest that GFP could be a valuable tool for the general analysis of protein transport machineries and pathways in a variety of organisms. Moreover, results from such studies could be important for the interpretation and optimization of classical experiments using GFP tagging.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oliveira, P.A.; Sanz, L., E-mail: lsanz@infis.ufu.br

This work provides a complete description of entanglement properties between electrons inside coupled quantum molecules, nanoestructures which consist of two quantum dots. Each electron can tunnel between the two quantum dots inside the molecule, being also coupled by Coulomb interaction. First, it is shown that Bell states act as a natural basis for the description of this physical system, defining the characteristics of the energy spectrum and the eigenstates. Then, the entanglement properties of the eigenstates are discussed, shedding light on the roles of each physical parameters on experimental setup. Finally, a detailed analysis of the dynamics shows the pathmore » to generate states with a high degree of entanglement, as well as physical conditions associated with coherent oscillations between separable and Bell states.« less

Geometrical approach to tumor growth.

PubMed

Escudero, Carlos

2006-08-01

Tumor growth has a number of features in common with a physical process known as molecular beam epitaxy. Both growth processes are characterized by the constraint of growth development to the body border, and surface diffusion of cells and particles at the growing edge. However, tumor growth implies an approximate spherical symmetry that makes necessary a geometrical treatment of the growth equations. The basic model was introduced in a former paper [C. Escudero, Phys. Rev. E 73, 020902(R) (2006)], and in the present work we extend our analysis and try to shed light on the possible geometrical principles that drive tumor growth. We present two-dimensional models that reproduce the experimental observations, and analyze the unexplored three-dimensional case, for which interesting conclusions on tumor growth are derived.

Ship dynamics for maritime ISAR imaging.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doerry, Armin Walter

2008-02-01

Demand is increasing for imaging ships at sea. Conventional SAR fails because the ships are usually in motion, both with a forward velocity, and other linear and angular motions that accompany sea travel. Because the target itself is moving, this becomes an Inverse- SAR, or ISAR problem. Developing useful ISAR techniques and algorithms is considerably aided by first understanding the nature and characteristics of ship motion. Consequently, a brief study of some principles of naval architecture sheds useful light on this problem. We attempt to do so here. Ship motions are analyzed for their impact on range-Doppler imaging using Inversemore » Synthetic Aperture Radar (ISAR). A framework for analysis is developed, and limitations of simple ISAR systems are discussed.« less

Diffusion of anthracene derivatives on Cu(111) studied by STM and DFT

NASA Astrophysics Data System (ADS)

Wyrick, Jonathan; Bartels, Ludwig; Einstein, Theodore

2014-03-01

Substituted anthracenes have drawn attention due to their ability to diffuse uniaxially on a Cu(111) surface. We compare anthracene to three of its derivatives whose 9,10 hydrogens are replaced by elements of the chalcogen group that act as linkers binding the molecules to a Cu(111) substrate. DFT calculations shed light on STM imaging and diffusion studies on the three substituted species. We present an analysis of the DFT results in which energetic contributions to the diffusion barriers are partitioned among the Kohn-Sham orbitals, allowing us to make assignments as to how each orbital affects diffusion for each species and draw comparisons between them. Present address: Center for Nanoscale Science and Technology, NIST, Gaithersburg, MD.

Stochastic Estimation and Non-Linear Wall-Pressure Sources in a Separating/Reattaching Flow

NASA Technical Reports Server (NTRS)

Naguib, A.; Hudy, L.; Humphreys, W. M., Jr.

2002-01-01

Simultaneous wall-pressure and PIV measurements are used to study the conditional flow field associated with surface-pressure generation in a separating/reattaching flow established over a fence-with-splitter-plate geometry. The conditional flow field is captured using linear and quadratic stochastic estimation based on the occurrence of positive and negative pressure events in the vicinity of the mean reattachment location. The results shed light on the dominant flow structures associated with significant wall-pressure generation. Furthermore, analysis based on the individual terms in the stochastic estimation expansion shows that both the linear and non-linear flow sources of the coherent (conditional) velocity field are equally important contributors to the generation of the conditional surface pressure.

First-principles study of direct and indirect optical absorption in BaSnO3

NASA Astrophysics Data System (ADS)

Kang, Youngho; Peelaers, Hartwin; Krishnaswamy, Karthik; Van de Walle, Chris G.

2018-02-01

We report first-principles results for the electronic structure and the optical absorption of perovskite BaSnO3 (BSO). BSO has an indirect fundamental gap, and hence, both direct and indirect transitions need to be examined. We assess direct absorption by calculations of the dipole matrix elements. The phonon-assisted indirect absorption spectrum at room temperature is calculated using a quasiclassical approach. Our analysis provides important insights into the optical properties of BSO and addresses several inconsistencies in the results of optical absorption experiments. We shed light on the variety of bandgap values that have been previously reported, concluding that the indirect gap is 2.98 eV and the direct gap is 3.46 eV.

Peer effects in risk aversion.

PubMed

Balsa, Ana I; Gandelman, Néstor; González, Nicolás

2015-01-01

We estimate peer effects in risk attitudes in a sample of high school students. Relative risk aversion is elicited from surveys administered at school. Identification of peer effects is based on parents not being able to choose the class within the school of their choice, and on the use of instrumental variables conditional on school-grade fixed effects. We find a significant and quantitatively large impact of peers' risk attitudes on a male individual's coefficient of risk aversion. Specifically, a one standard deviation increase in the group's coefficient of risk aversion increases an individual's risk aversion by 43%. Our findings shed light on the origin and stability of risk attitudes and, more generally, on the determinants of economic preferences. © 2014 Society for Risk Analysis.

Quantum and semiclassical physics behind ultrafast optical nonlinearity in the midinfrared: the role of ionization dynamics within the field half cycle.

PubMed

Serebryannikov, E E; Zheltikov, A M

2014-07-25

Ultrafast ionization dynamics within the field half cycle is shown to be the key physical factor that controls the properties of optical nonlinearity as a function of the carrier wavelength and intensity of a driving laser field. The Schrödinger-equation analysis of a generic hydrogen quantum system reveals universal tendencies in the wavelength dependence of optical nonlinearity, shedding light on unusual properties of optical nonlinearities in the midinfrared. For high-intensity low-frequency fields, free-state electrons are shown to dominate over bound electrons in the overall nonlinear response of a quantum system. In this regime, semiclassical models are shown to offer useful insights into the physics behind optical nonlinearity.

Economies of scale and asset values in power production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Considine, T.J.

While innovative trading tools have become an increasingly important aspect of the electricity business, the future of any firm in the industry boils down to a basic bread and butter issue of generating power at competitive costs. While buying electricity from power pools at spot prices instead of generating power to service load may be profitable for some firms in the short run, the need to efficiently utilize existing plants in the long run remains. These competitive forces will force the closure of many inefficient plants. As firms close plants and re-evaluate their generating asset portfolios, the basic structure ofmore » the industry will change. This article presents some quantitative analysis that sheds light on this unfolding transformation.« less

The correcting method for the estimation of correlation energies of MF2 (M = Be, Mg, Ca) set molecules

NASA Astrophysics Data System (ADS)

Zhuo, Shuping; Wei, Jichong; Ju, Guanzhi

The intrapair and interpair correlation energies of MF2 (M = Be, Mg, Ca) set molecules are calculated and analysed, and the transferability of inner core correlation effects of Mδ+ are investigated. A detailed analysis of the comparison of correlation energies of neutral atoms with their corresponding ions of Mδ+ and Fδ-/2 is given in terms of the correlation contribution of this component. The study reveals that the total correlation energy of MF2 molecules can be obtained by summing the correlation contributions of Mδ+ and two Fδ-/2 components. This simple estimation method does shed light on the importance of searching useful means for the calculation of electron correlation energy for large biological systems.

Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin

PubMed Central

Boureau, Y-Lan; Dayan, Peter

2011-01-01

Affective valence lies on a spectrum ranging from punishment to reward. The coding of such spectra in the brain almost always involves opponency between pairs of systems or structures. There is ample evidence for the role of dopamine in the appetitive half of this spectrum, but little agreement about the existence, nature, or role of putative aversive opponents such as serotonin. In this review, we consider the structure of opponency in terms of previous biases about the nature of the decision problems that animals face, the conflicts that may thus arise between Pavlovian and instrumental responses, and an additional spectrum joining invigoration to inhibition. We use this analysis to shed light on aspects of the role of serotonin and its interactions with dopamine. PMID:20881948

Partial Least Squares Based Gene Expression Analysis in EBV- Positive and EBV-Negative Posttransplant Lymphoproliferative Disorders.

PubMed

Wu, Sa; Zhang, Xin; Li, Zhi-Ming; Shi, Yan-Xia; Huang, Jia-Jia; Xia, Yi; Yang, Hang; Jiang, Wen-Qi

2013-01-01

Post-transplant lymphoproliferative disorder (PTLD) is a common complication of therapeutic immunosuppression after organ transplantation. Gene expression profile facilitates the identification of biological difference between Epstein-Barr virus (EBV) positive and negative PTLDs. Previous studies mainly implemented variance/regression analysis without considering unaccounted array specific factors. The aim of this study is to investigate the gene expression difference between EBV positive and negative PTLDs through partial least squares (PLS) based analysis. With a microarray data set from the Gene Expression Omnibus database, we performed PLS based analysis. We acquired 1188 differentially expressed genes. Pathway and Gene Ontology enrichment analysis identified significantly over-representation of dysregulated genes in immune response and cancer related biological processes. Network analysis identified three hub genes with degrees higher than 15, including CREBBP, ATXN1, and PML. Proteins encoded by CREBBP and PML have been reported to be interact with EBV before. Our findings shed light on expression distinction of EBV positive and negative PTLDs with the hope to offer theoretical support for future therapeutic study.

Nanowire arrays restore vision in blind mice.

PubMed

Tang, Jing; Qin, Nan; Chong, Yan; Diao, Yupu; Yiliguma; Wang, Zhexuan; Xue, Tian; Jiang, Min; Zhang, Jiayi; Zheng, Gengfeng

2018-03-06

The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspired by the structure and function of photoreceptors in retinas, we develop artificial photoreceptors based on gold nanoparticle-decorated titania nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. Green, blue and near UV light responses in the retinal ganglion cells (RGCs) are restored with a spatial resolution better than 100 µm. ON responses in RGCs are blocked by glutamatergic antagonists, suggesting functional preservation of the remaining retinal circuits. Moreover, neurons in the primary visual cortex respond to light after subretinal implant of nanowire arrays. Improvement in pupillary light reflex suggests the behavioral recovery of light sensitivity. Our study will shed light on the development of a new generation of optoelectronic toolkits for subretinal prosthetic devices.

Photoacoustic and filter measurements related to aerosol light absorption during the Northern Front Range Air Quality Study (Colorado 1996/1997)

NASA Astrophysics Data System (ADS)

Moosmüller, H.; Arnott, W. P.; Rogers, C. F.; Chow, J. C.; Frazier, C. A.; Sherman, L. E.; Dietrich, D. L.

1998-11-01

A new photoacoustic instrument for the measurement of aerosol light absorption was collocated with conventional aerosol instrumentation during the 1996-1997 winter intensive monitoring period of the Northern Front Range Air Quality Study. Measurements of the light absorption efficiency for black carbon were 5 m2/g at 685 nm and 10 m2/g at 532 nm, and for elemental carbon, they were 3.6 m2/g at 685 nm. We show that these values together with previous photoacoustic measurements of aerosol light absorption shed some light on the wavelength dependence of absorption efficiency for carbonaceous aerosol in the visible and near-visible region. Integrating plate type filter measurements of aerosol light absorption result in far larger values than those measured with the photoacoustic instrument. We demonstrate that a recently published correction technique [Horvath, 1997] can yield improved agreement.

A Psychology of Hypermedia: A Conceptual Framework for R&D.

ERIC Educational Resources Information Center

Borsook, Terry K.; Higginbotham-Wheat, Nancy

This paper explores the insights that psychology can offer in shedding light on why hypermedia may work and thus in suggesting fruitful areas for future research. The philosophy underlying the paper is that research into the instructional efficacy of hypermedia should begin with a knowledge and appreciation of relevant psychological phenomena.…

The Relationship between Attachment and Eating Disorders: A Review of the Literature.

ERIC Educational Resources Information Center

Lewis, Robin Marie

A review was conducted of literature published over the past 15 years pertaining to attachment factors associated with the formation of anorexia and bulimia nervosa. This review first aims to shed light on the connections between disruption in attachment and psychological disturbances underlying eating disorders. The second purpose is to encourage…

Intradistrict Public School Funding Equity, Community Resources, and Performance in Nashville, Tennessee

ERIC Educational Resources Information Center

Klein, Christopher C.

2008-01-01

A large literature finds that resources are not significant determinants of student performance. These results may arise because resources really do not matter in public education or because local school districts allocate additional resources to poorer performing schools. To shed light on this issue, a unique data set for the Metropolitan…

Publish or Perish: Academic Life as Management Faculty Live It

ERIC Educational Resources Information Center

Miller, Alan N.; Taylor, Shannon G.; Bedeian, Arthur G.

2011-01-01

Purpose: Although many in academe have speculated about the effects of pressure to publish on the management discipline--often referred to as "publish or perish"--prevailing knowledge has been based on anecdotal rather than empirical evidence. The aim of the present paper is to shed light on the perceptions of management faculty…

Revisiting Vygotsky and Gardner: Realizing Human Potential

ERIC Educational Resources Information Center

Beliavsky, Ninah

2006-01-01

In this article, the author discusses her views on philosophies and theories by Lev Semenovich Vygotsky and Howard Gardner. Here, she argues that Vygotsky's ideas should be viewed through the prism of Gardner's theory of Multiple Intelligences, and that the combination of these concepts can shed new light on education--on teaching and learning.…

Temperature Dependence of Cryogenic Ammonia-Water Ice Mixtures and Implications for Icy Satellite Surfaces

NASA Technical Reports Server (NTRS)

Dalton, J. B., III; Curchin, J. M.; Clark, R. N.

2001-01-01

Infrared spectra of ammonia-water ice mixtures reveal temperature-dependent absorption bands due to ammonia. These features, at 1.04, 2.0, and 2.25 microns, may shed light on the surface compositions of the Galilean and Saturnian satellites. Additional information is contained in the original extended abstract.

The Role of Teacher Questions and the Socratic Method in EFL Classrooms in Kuwait

ERIC Educational Resources Information Center

Al-Darwish, Salwa

2012-01-01

The present study sheds light on teaching English through two ways of questioning (Socratic & Traditional) methods in Kuwaiti elementary public schools. Data were collected through a qualitative observational method. The study engaged 15 female participants, seven of whom were newly graduate English language teachers with experience in how…

Principles of Food Science Class Sheds Light on Chemistry

ERIC Educational Resources Information Center

Ward, Janet

2004-01-01

Many students are curious about the steps in food preparation. As a result of such experiences, the author of this article began to incorporate science demonstrations into food preparation classes. She conducted research, developed resources, and piloted the "Principles of Food Science" class over the next 6 years. "Principles of Food Science"…

Professional Responsibility--An Issue for Higher Education?

ERIC Educational Resources Information Center

Solbrekke, Tone Dyrdal; Karseth, Berit

2006-01-01

The aim of this article is to shed light on some aspects of professional responsibility by investigating students' visions of future work and notions of professional responsibility. The data is based on interviews with samples of freshmen in three educational programmes at the University of Oslo in Norway. The data has been analysed in relation to…

Emotional Intelligence in Gifted Students

ERIC Educational Resources Information Center

Zeidner, Moshe; Matthews, Gerald

2017-01-01

This article aims at shedding light on the emotional intelligence (EI) of gifted and high ability students. We begin by presenting a brief overview of EI theory and research and its relevance to gifted education. We then present theoretical considerations bearing on the nature of the relationship between cognitive and EI. This is followed by a…

The Historical, Present and Future "ness" of Environmental Education in India

ERIC Educational Resources Information Center

Almeida, Sylvia; Cutter-Mackenzie, Amy

2011-01-01

What is distinctive or indistinctive about environmental education in schools and other formal education settings in India? In essence, what is the "ness" of environmental education in the Indian education system? Our responses to these important questions form the focus of this paper, shedding light on the historical, present and future…

Social Capital as a Framework in Music Education Research

ERIC Educational Resources Information Center

Prest, Anita

2016-01-01

In recent years, an increasing number of researchers have chosen to examine various sociological dimensions of music education (e.g., inclusion, civic engagement) through the lens of social capital. Yet, there has been no systematic discussion of the capacity and limitations of this conceptual framework to shed light on these sociological…

Quo Vadis? LIS Postgraduate Education in the Philippines

ERIC Educational Resources Information Center

Dizon, Fernan R.; Sagun, Karryl Kim A.; Alfiler-Macalalad, Ana Grace P.

2011-01-01

The paper intends to shed light on the predicament faced by many Filipino. Librarians: the lack of local institutions offering a library and information science (LIS) postgraduate degree. The paper aims to reveal the state of Philippine LIS postgraduate education by considering the number of librarians who have pursued and are still pursuing…

Functional genomic approaches for understanding the mode of action of Bacillus sp biocontrol strains

USDA-ARS?s Scientific Manuscript database

Complete genome sequencing of several Bacillus sp. strains has shed new light on the mode of action of these antagonists of plant pathogens. The use of genomic data mining tools provided the ability to quickly determine the potential of these strains to produce bioactive secondary metabolites. Our B...

Developing Positive Young Adults: Lessons from Two Decades of YouthBuild Programs

ERIC Educational Resources Information Center

Ferguson, Ronald F.; Snipes, Jason; Hossain, Farhana; Manno, Michelle S.

2015-01-01

Youth development is a cornerstone of the YouthBuild program, which provides job skills training, academic support, counseling, and leadership opportunities to low-income, out-of-school young adults. This report presents findings from two separate research efforts that shed light on the process of youth transformation and identity development in…

A Charter for Improved Rural Youth Transition.

ERIC Educational Resources Information Center

South Dakota State Advisory Committee to the U.S. Commission on Civil Rights.

The Charter is intended to help shed light on rural youths' transition from education to work, and results from the 1977-78 activities of eight rural councils of the Work-Education Consortium. Recognizing the wide diversity of definitions for rural and nonmetropolitan, and understanding that rural youth are faced with economic and educational…

A sexy spin on nonrandom chromosome segregation.

PubMed

Charville, Gregory W; Rando, Thomas A

2013-06-06

Nonrandom chromosome segregation is an intriguing phenomenon linked to certain asymmetric stem cell divisions. In a recent report in Nature, Yadlapalli and Yamashita (2013) observe nonrandom segregation of X and Y chromosomes in Drosophila germline stem cells and shed light on the complex mechanisms of this fascinating process. Copyright © 2013 Elsevier Inc. All rights reserved.

Counterfactual Conditionals and False Belief: A Developmental Dissociation

ERIC Educational Resources Information Center

Perner, Josef; Sprung, Manuel; Steinkogler, Bettina

2004-01-01

The objective of this study was to explore factors that affect the difficulty of counterfactual reasoning in 3-5-year-old children and to shed light on the reason why counterfactual reasoning relates to understanding false belief [Cognitive Development, 13 (1998) 73-90]. Using travel scenarios, the difference between simple scenarios, in which…

Private Supplementary Tutoring in the Czech Republic

ERIC Educational Resources Information Center

Štastný, Vít

2016-01-01

The study contributes to the literature on private supplementary tutoring by shedding light on this phenomenon in the Czech Republic. The aim of the paper is to identify the reasons for seeking out private supplementary tutoring and to assess the factors underlying its demand. In the representative sample of 1,265 senior upper-secondary school…

Focus on Inhalants.

ERIC Educational Resources Information Center

Challenge: Safe, Disciplines, and Drug-Free Schools, 1994

1994-01-01

The use of inhalants is a major health concern among the school-age population. Information presented in this publication dispels the myths about inhalant use and presents common warning signs that alert teachers to a student's use. The short- and long-term effects of inhalant use are described to shed light on the health risks involved. Lesson…

Identifying and Describing Tutor Archetypes: The Pragmatist, the Architect, and the Surveyor

ERIC Educational Resources Information Center

Harootunian, Jeff A.; Quinn, Robert J.

2008-01-01

In this article, the authors identify and anecdotally describe three tutor archetypes: the pragmatist, the architect, and the surveyor. These descriptions, based on observations of remedial mathematics tutors at a land-grant university, shed light on a variety of philosophical beliefs regarding and pedagogical approaches to tutoring. An analysis…

Power, Language, and Professional Choices: A Hermeneutic Approach To Teaching Technical Communication.

ERIC Educational Resources Information Center

Tillery, Denise

2001-01-01

Argues that the philosophical hermeneutics of Hans-Georg Gadamer provides a useful theoretical framework from which to discuss ethical issues in the technical communication classroom. Analyzes a previously published case study to demonstrate how hermeneutics can shed light on the ways that writers can be unconscious of ethical problems in their…

Synthesis and Characterization of Heterobimetallic Iridium-Aluminum and Rhodium-Aluminum Complexes.

PubMed

Brewster, Timothy P; Nguyen, Tan H; Li, Zhongjing; Eckenhoff, William T; Schley, Nathan D; DeYonker, Nathan J

2018-02-05

We demonstrate the synthesis and characterization of a new class of late-transition-metal-aluminum heterobimetallic complexes via a novel synthetic pathway. Complexes of this type are exceedingly rare. Joint experimental and theoretical data sheds light on the electronic effect of ligands containing aluminum moieties on late-transition-metal complexes.

Studies Shed Light on How Cheating Impedes Learning

ERIC Educational Resources Information Center

Sparks, Sarah D.

2011-01-01

This article reports on new research which shows that, when students succeed at cheating on tests, they get duped into thinking they're smarter than they really are. In four experiments detailed in the March "Proceedings of the National Academy of Sciences", researchers from the Harvard Business School and Duke University found that cheaters pay…

Lifting the Lid: How Prison Writing Workshops Shed Light on the Social Shadow

ERIC Educational Resources Information Center

Toso, Erec

2016-01-01

While the social, political, economic, educational, and cultural consequences of high rates of incarceration have been well documented, the social psychological dynamics have not received as much discussion. I offer here a first person narrative reflection on the connections between a writing workshops and raising social awareness of the realities…

Learning from Comparing Multiple Examples: On the Dilemma of "Similar" or "Different"

ERIC Educational Resources Information Center

Guo, Jian-Peng; Pang, Ming Fai; Yang, Ling-Yan; Ding, Yi

2012-01-01

Although researchers have demonstrated that studying multiple examples is more effective than studying one example to facilitate learning, the principles found in the literature for designing multiple examples remain ambiguous. This paper reviews variation theory research on example design which sheds light on unclear issues regarding the effects…

Teaching Culture in the Foreign Language Classroom.

ERIC Educational Resources Information Center

Brooks, Nelson

1965-01-01

An attempt is made to define and describe culture for foreign language teachers, particularly those involved in the earlier phases of instruction. Reasons advanced for the inclusion of culture in language study center around the light it sheds on the real meanings of the target language. Projects, activities, and reports on culture in the language…

Variability, Constraints, and Creativity: Shedding Light on Claude Monet.

ERIC Educational Resources Information Center

Stokes, Patricia D.

2001-01-01

Discusses how creative individuals maintain high levels of variability, examining how Claude Monet's habitually high level of variability in painting was acquired during his childhood and early apprenticeship and maintained throughout his adult career by a continuous series of task constraints imposed by the artist on his own work. For Monet,…

Early Literacy in Cuba: Lessons for America

ERIC Educational Resources Information Center

Abel, Carolyn Davidson; Abel, Charles Frederick

2017-01-01

How did Cuba erase illiteracy in a single year? How did they combine both a phonics approach with the constructivist meaning-based model for teaching reading that we cannot seem to manage here in the states? This paper seeks to shed light on Cuba's impressive 1961 National Literacy Campaign and reflects upon implications for early literacy…

Thinking Comprehensively about Education: Spaces of Educative Possibility and Their Implications for Public Policy

ERIC Educational Resources Information Center

Dixon-Roman, Ezekiel, Ed.; Gordon, Edmund W., Ed.

2012-01-01

While much is known about the critical importance of educative experiences outside of school, little is known about the social systems, community programs, and everyday practices that can facilitate learning outside of the classroom. "Thinking Comprehensively About Education" sheds much-needed light on those systems, programs, and…

Diversity in Information Technology Education: Issues and Controversies

ERIC Educational Resources Information Center

Trajkovski, Goran, Ed.

2006-01-01

"Diversity in Information Technology Education: Issues and Controversies" sheds light on the status of diversity in the field of IT education. It identifies a wide range of problems that educators face on a daily basis, and gives practical, applicable solutions, mainly by showcasing successful and replicable examples. The chapters in "Diversity in…

Historical growth plots in the Pacific Southwest

Treesearch

Lawrence A. Rabin; William W. Oliver; Robert F. Powers; Martin W. Ritchie; Matt D. Busse; Eric E. Knapp

2009-01-01

In the past, researchers from the Pacific Southwest Research Station (PSW) undertook forest growth studies to evaluate how best to manage timber resources. However, historical and future data collected at PSW growth plots also have the potential to increase our understanding of the ecological processes occurring in our forests and shed light on national issues of...

The Swedish Schools Inspectorate's View of Swedish Schools

ERIC Educational Resources Information Center

Lindström, Lisbeth; Perdahl, Solange

2014-01-01

The purpose of this article is to shed some light on and give some examples of how the Swedish schools have interpreted their mission of educating young people and preparing them for the role of active citizens. More specifically, we are interested in how the "good" or "aspirational" school is presented in the reports published…

Appendix B: Fisher, lynx, wolverine summary of distribution information

Treesearch

Mary Maj

1994-01-01

We present maps depicting distributions of fisher, lynx, and wolverine in the western United States since 1961. Comparison of past and current distributions of species can shed light on population persistence, periods of population isolation, meta-population structure, and important connecting landscapes. Information on the distribution of the American marten is not...

A taxonomy-based approach to shed light on the babel of mathematical analogies for rice simulation

USDA-ARS?s Scientific Manuscript database

For most biophysical domains, different models are available and the extent to which their structures differ with respect to differences in outputs was never quantified. We use a taxonomy-based approach to address the question with thirteen rice models. Classification keys and binary attributes for ...

Shedding Light on Students' Technology Preferences: Implications for Academic Development

ERIC Educational Resources Information Center

Mirriahi, Negin; Alonzo, Dennis

2015-01-01

This study built on previous research in 2010 to determine changes to students' current use of and expectations for future integration of technologies in their learning experience. The findings reveal a continued trend of conservative technology use amongst students but with a growing demand for more integration of technologies for assessment and…

Who or What Contributes to Student Satisfaction in Different Blended Learning Modalities?

ERIC Educational Resources Information Center

Diep, Anh-Nguyet; Zhu, Chang; Struyven, Katrien; Blieck, Yves

2017-01-01

Different blended learning (BL) modalities and the interaction effect between human and technological factors on student satisfaction need adequately researched to shed more light on successful BL implementation. The objective of the present article is three-fold: (1) to present a model to predict student satisfaction with BL programs, (2) to…

The ECAR Study of Undergraduate Students and Information Technology, 2010. Key Findings

ERIC Educational Resources Information Center

Smith, Shannon D.; Caruso, Judith Borreson

2010-01-01

This document presents the key findings from "The ECAR Study of Undergraduate Students and Information Technology, 2010". Since 2004, the annual ECAR (EDUCAUSE Center for Applied Research) study of undergraduate students and information technology has sought to shed light on how information technology affects the college experience. We…

The Social Ecological Challenges of Rural Victim Advocacy: An Exploratory Study

ERIC Educational Resources Information Center

McGrath, Shelly A.; Johnson, Melencia; Miller, Michelle Hughes

2012-01-01

This article re-centers an ecological model traditionally used to understand the experiences of interpersonal violence victims around the perceptions and experiences of victim advocates. We suggest that the development of such a model might shed light on rural-urban differences in the accessibility and availability of support services in rural…

How Can Organizational and Sociocultural Learning Theories Shed Light on District Instructional Reform?

ERIC Educational Resources Information Center

Knapp, Michael S.

2008-01-01

This article explores how organizational and sociocultural learning theories can help us to understand the problem of system-wide instructional reform in school districts. After briefly summarizing the central challenges facing leaders in such districts, the article reviews key ideas associated with each theoretical lens and considers how each…

Society and Health in the Lower Rio Grande Valley.

ERIC Educational Resources Information Center

Madsen, William

Shedding light on problems of mental health and illness that have baffled public health workers attempting to improve the health and welfare of Mexican Americans living in the lower Rio Grande Valley, this document reports the folk customs, social organization, medical practices, and beliefs of the Mexican American of this area. Chapters describe…