Science.gov

Sample records for analytic receiver analysis

  1. ADMX Receiver and Analysis

    NASA Astrophysics Data System (ADS)

    Malagon, Ana; ADMX Collaboration

    2016-03-01

    ADMX looks for the excess radiation deposited into a cavity from the conversion of a dark matter axion into a microwave photon. The sensitivity of the experiment increases by reducing the background thermal noise and minimizing the electronic noise of the readout system. The axion masses that the experiment can detect are determined by the resonant frequency of the cavity mode of interest, which is tuned using a two rod configuration. One can also increase the search rate by measuring the output from two cavity modes at once, which requires two separate readout schemes. I will discuss the ADMX dual-channel receiver which has been upgraded to have near quantum-limited sensitivity on both channels, and describe how the correct modes are verified, using simulations, in the presence of dense electromagnetic structure. I conclude by describing upgrades to the ADMX analysis which allow for real-time exclusion limits. Supported by DOE Grants DE-FG02-97ER41029, DE-FG02-96ER40956, DE- AC52-07NA27344, DE-AC03-76SF00098, and the Livermore LDRD program.

  2. Multimedia Analysis plus Visual Analytics = Multimedia Analytics

    SciTech Connect

    Chinchor, Nancy; Thomas, James J.; Wong, Pak C.; Christel, Michael; Ribarsky, Martin W.

    2010-10-01

    Multimedia analysis has focused on images, video, and to some extent audio and has made progress in single channels excluding text. Visual analytics has focused on the user interaction with data during the analytic process plus the fundamental mathematics and has continued to treat text as did its precursor, information visualization. The general problem we address in this tutorial is the combining of multimedia analysis and visual analytics to deal with multimedia information gathered from different sources, with different goals or objectives, and containing all media types and combinations in common usage.

  3. Receiver System Analysis and Optimization

    DTIC Science & Technology

    2013-01-01

    True Top-Down Design Methodology .................................. 5 Figure 4. Generic 16- QAM direct-conversion receiver...ADC 16- QAM decoder Figure 4. Generic 16- QAM direct-conversion receiver Complex digitally generated signals defy traditional spreadsheet...Intercept Point Three QAM Quadrature Amplitude Modulation SNR Signal-to-Noise Ratio USAF USR VCO United States Air Force Upsampling Ratio Voltage Controlled Oscillator

  4. Exploratory Analysis in Learning Analytics

    ERIC Educational Resources Information Center

    Gibson, David; de Freitas, Sara

    2016-01-01

    This article summarizes the methods, observations, challenges and implications for exploratory analysis drawn from two learning analytics research projects. The cases include an analysis of a games-based virtual performance assessment and an analysis of data from 52,000 students over a 5-year period at a large Australian university. The complex…

  5. Analytical estimation of laser phase noise induced BER floor in coherent receiver with digital signal processing.

    PubMed

    Vanin, Evgeny; Jacobsen, Gunnar

    2010-03-01

    The Bit-Error-Ratio (BER) floor caused by the laser phase noise in the optical fiber communication system with differential quadrature phase shift keying (DQPSK) and coherent detection followed by digital signal processing (DSP) is analytically evaluated. An in-phase and quadrature (I&Q) receiver with a carrier phase recovery using DSP is considered. The carrier phase recovery is based on a phase estimation of a finite sum (block) of the signal samples raised to the power of four and the phase unwrapping at transitions between blocks. It is demonstrated that errors generated at block transitions cause the dominating contribution to the system BER floor when the impact of the additive noise is negligibly small in comparison with the effect of the laser phase noise. Even the BER floor in the case when the phase unwrapping is omitted is analytically derived and applied to emphasize the crucial importance of this signal processing operation. The analytical results are verified by full Monte Carlo simulations. The BER for another type of DQPSK receiver operation, which is based on differential phase detection, is also obtained in the analytical form using the principle of conditional probability. The principle of conditional probability is justified in the case of differential phase detection due to statistical independency of the laser phase noise induced signal phase error and the additive noise contributions. Based on the achieved analytical results the laser linewidth tolerance is calculated for different system cases.

  6. Analytic process and dreaming about analysis.

    PubMed

    Sirois, François

    2016-12-01

    Dreams about the analytic session feature a manifest content in which the analytic setting is subject to distortion while the analyst appears undisguised. Such dreams are a consistent yet infrequent occurrence in most analyses. Their specificity consists in never reproducing the material conditions of the analysis as such. This paper puts forward the following hypothesis: dreams about the session relate to some aspects of the analyst's activity. In this sense, such dreams are indicative of the transference neurosis, prefiguring transference resistances to the analytic elaboration of key conflicts. The parts taken by the patient and by the analyst are discussed in terms of their ability to signal a deepening of the analysis.

  7. Analysis of Optimum Heterodyne Receivers for Coherent Lidar Applications

    NASA Technical Reports Server (NTRS)

    Amzajerdian, Farzin

    2002-01-01

    A full analysis of the combined effects of all the noise sources of optical heterodyne receiver and the interaction between the competing control parameters of the receiver detector and pre-amplifier will be presented. This analysis provides the mean for true optimization of the coherent lidar receiver. The significance of the optimization of heterodyne receiver is shown for 2-micron coherent lidar.

  8. Phenol Analysis -- Some Analytical Considerations

    NASA Technical Reports Server (NTRS)

    Starkey, R. J., Jr.

    1971-01-01

    Contamination of potable water supplies with halogenated phenols in concentrations of 2-10 parts per billion (ppb) produces objectionable tastes and odors capable of influencing consumer acceptability. Routine analysis by the distillation/ 4-aminoantipyrine method is limited by lack of sensitivity and subject to interference by aryl amines. This has been overcome by developing a continuous liquid-liquid extraction system to selectively isolate phenols and eliminate major interfering substances. Stable reagents have been formulated to reduce blank color and extend sensitivity. Equipment suitable for analysis of phenols at the 1 ppb level or less in 20 minutes is described.

  9. ANALYTICAL RESULTS FOR MOX COLEMANITE SAMPLES RECEIVED ON JULY 22, 2013

    SciTech Connect

    Reigel, M.; Best, D.

    2013-08-13

    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the boron oxide content of the colemanite raw aggregate material prior to it being mixed into the concrete. SRNL received ten samples of colemanite for analysis on July 22, 2013. The elemental boron content of each sample was measured according to ASTM C 1301. The boron oxide content was calculated using the oxide conversion factor for boron.

  10. ANALYTICAL RESULTS FOR MOX COLEMANITE SAMPLES RECEIVED ON JULY 22, 2013

    SciTech Connect

    Reigel, M.; Best, D.

    2014-05-19

    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the boron oxide content of the colemanite raw aggregate material prior to it being mixed into the concrete. SRNL received ten samples of colemanite for analysis on July 22, 2013. The elemental boron content of each sample was measured according to ASTM C 1301. The boron oxide content was calculated using the oxide conversion factor for boron.

  11. Analytical Results For MOX Colemanite Concrete Samples Received On November, 2013

    SciTech Connect

    Reigel, Marissa M.

    2013-12-18

    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the total density, partial hydrogen density, and partial boron density of the colemanite concrete. SRNL received two samples of colemanite concrete for analysis on November 21, 2013. The average total density of each of the samples measured by the ASTM method C 642, the average partial hydrogen density was measured using method ASTM E 1131, and the average partial boron density of each sample was measured according to ASTM C 1301. For all the samples tested, the total density and the boron partial density met or exceeded the specified limit. None of the samples met the lower limit for hydrogen partial density.

  12. ANALYTICAL RESULTS FOR MOX COLEMANITE CONCRETE SAMPLES RECEIVED ON SEPTEMBER 4, 2013

    SciTech Connect

    Reigel, M.

    2014-05-19

    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the total density, partial hydrogen density, and partial boron density of the colemanite concrete. SRNL received three samples of colemanite concrete for analysis on September 4, 2013. The average total density of each of the samples measured by the ASTM method C 642, the average partial hydrogen density was measured using method ASTM E 1131, and the average partial boron density of each sample was measured according to ASTM C 1301. The lower limits and measured values for the total density, hydrogen partial density, and boron partial density are presented. For all the samples tested, the total density and the boron partial density met or exceeded the specified limit. None of the samples met the lower limit for hydrogen partial density.

  13. ANALYTICAL RESULTS FOR MOX COLEMANITE CONCRETE SAMPLES RECEIVED ON NOVEMBER 21, 2013

    SciTech Connect

    Reigel, M.

    2014-05-19

    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the total density, partial hydrogen density, and partial boron density of the colemanite concrete. SRNL received two samples of colemanite concrete for analysis on November 21, 2013. The average total density of each of the samples measured by the ASTM method C 642, the average partial hydrogen density was measured using method ASTM E 1131, and the average partial boron density of each sample was measured according to ASTM C 1301. The lower limits and measured values for the total density, hydrogen partial density, and boron partial density are presented. For all the samples tested, the total density and the boron partial density met or exceeded the specified limit. None of the samples met the lower limit for hydrogen partial density.

  14. Analytical Results For MOX Colemanite Concrete Samples Received On September 4, 2013

    SciTech Connect

    Reigel, Marissa M.

    2013-09-24

    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the total density, partial hydrogen density, and partial boron density of the colemanite concrete. SRNL received three samples of colemanite concrete for analysis on September 4, 2013. The average total density of each of the samples measured by the ASTM method C 642, the average partial hydrogen density was measured using method ASTM E 1131, and the average partial boron density of each sample was measured according to ASTM C 1301. The lower limits and measured values for the total density, hydrogen partial density, and boron partial density are presented. For all the samples tested, the total density and the boron partial density met or exceeded the specified limit. None of the samples met the lower limit for hydrogen partial density.

  15. The Relation of Perceived and Received Social Support to Mental Health among First Responders: A Meta-Analytic Review

    ERIC Educational Resources Information Center

    Prati, Gabriele; Pietrantoni, Luca

    2010-01-01

    There are plenty of theories that may support the protective role of social support in the aftermath of potentially traumatic events. This meta-analytic review examined the role of received and perceived social support in promoting mental health among first responders (e.g., firefighters, police officers, and paramedics or emergency medical…

  16. Visual analytics for power grid contingency analysis.

    PubMed

    Pak Chung Wong; Zhenyu Huang; Yousu Chen; Mackey, Patrick; Shuangshuang Jin

    2014-01-01

    Contingency analysis employs different measures to model scenarios, analyze them, and then derive the best response to any threats. A proposed visual-analytics pipeline for power grid management can transform approximately 100 million contingency scenarios to a manageable size and form. Grid operators can examine individual scenarios and devise preventive or mitigation strategies in a timely manner. Power grid engineers have applied the pipeline to a Western Electricity Coordinating Council power grid model.

  17. Analytical techniques and instrumentation: A compilation. [analytical instrumentation, materials performance, and systems analysis

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Technical information is presented covering the areas of: (1) analytical instrumentation useful in the analysis of physical phenomena; (2) analytical techniques used to determine the performance of materials; and (3) systems and component analyses for design and quality control.

  18. ANALYTICAL RESULTS FOR MOX COLEMANITE CONCRETE SAMPLES RECEIVED ON JANUARY 15, 2013

    SciTech Connect

    Reigel, M.; Best, D.

    2013-02-13

    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the total density, partial hydrogen density, and partial boron density of the colemanite concrete. SRNL received twelve samples of colemanite concrete for analysis on January 15, 2013. The average total density of each of the samples measured by the ASTM method C 642, the average partial hydrogen density was measured using method ASTM E 1311, and the average partial boron density of each sample was measured according to ASTM C 1301. The lower limits and measured values for the total density, hydrogen partial density, and boron partial density are presented. For all the samples tested, the total density and the hydrogen partial density met or exceeded the specified limit. All of the samples met or exceeded the boron partial density lower bound with the exception of samples G3-M11-2000-H, G3-M11-3000-M, and G5-M1-3000-H which are below the limit of 1.65E-01 g/cm3.

  19. ANALYTICAL RESULTS FOR MOX COLEMANITE CONCRETE SAMPLES RECEIVED ON JANUARY 15, 2013

    SciTech Connect

    Reigel, M.

    2014-05-19

    The Mixed Oxide Fuel Fabrication Facility (MFFF) will use colemanite bearing concrete neutron absorber panels credited with attenuating neutron flux in the criticality design analyses and shielding operators from radiation. The Savannah River National Laboratory (SRNL) is tasked with measuring the total density, partial hydrogen density, and partial boron density of the colemanite concrete. SRNL received twelve samples of colemanite concrete for analysis on January 15, 2013. The average total density of each of the samples measured by the ASTM method C 642, the average partial hydrogen density was measured using method ASTM E 1131, and the average partial boron density of each sample was measured according to ASTM C 1301. The lower limits and measured values for the total density, hydrogen partial density, and boron partial density are presented. For all the samples tested, the total density and the hydrogen partial density met or exceeded the specified limit. All of the samples met or exceeded the boron partial density lower bound with the exception of samples G3-M11-2000-H, G3-M11-3000-M, and G5-M1-3000-H which are below the limit of 1.65E-01 g/cm{sup 3}.

  20. Analytical and experimental performance evaluation of an integrated Si-photonic balanced coherent receiver in a colorless scenario.

    PubMed

    Morsy-Osman, Mohamed; Chagnon, Mathieu; Xu, Xian; Zhuge, Qunbi; Poulin, Michel; Painchaud, Yves; Pelletier, Martin; Paquet, Carl; Plant, David V

    2014-03-10

    We study analytically and experimentally the performance limits of a Si-photonic (SiP) balanced coherent receiver (CRx) co-packaged with transimpedance amplifiers (TIAs) in a colorless WDM scheme. Firstly, the CRx architecture is depicted and characterization results are presented. Secondly, an analytical expression for the signal-to-noise ratio (SNR) at the CRx output is rigorously developed and various noise sources in the context of colorless reception are outlined. Thirdly, we study experimentally the system-level CRx performance in colorless reception of 16 × 112 Gbps PDM-QPSK WDM channels. Using a 15.5 dBm local oscillator (LO) power, error free transmissions over 4800 and 4160 km at received powers of -3 and -21 dBm per channel, respectively, were achieved in a fully colorless and preamplifierless reception. Next, a set of measurements on one of the center WDM channels is performed where the LO power, received signal power, distance, and number of channels presented to the CRx are swept to evaluate the performance limits of colorless reception. Results reveal that the LO beating with optical noise incoming with the signal is a dominant noise source regardless of received signal power. In the high received signal power regime (~0 dBm/channel), the self-beat noise from out-of-band (OOB) channels is an additional major noise source especially for small LO-to-signal power ratio, short reach and large number of OOB channels. For example, at a received signal power of 0 dBm/channel after 1600 km transmission, the SNR difference between the fully filtered and colorless scenarios, where 1 and 16 channels are passed to the CRx respectively, grows from 0.5 to 3.3 dB as the LO power changes from 12 to 0 dBm. For low received power (~-12 dBm/channel), the effect of OOB channels becomes minor while the receiver shot and thermal noises become more significant. We identify the common mode rejection ratio (CMRR) and sensitivity as the two important CRx specifications that

  1. Visual Analytics for Power Grid Contingency Analysis

    SciTech Connect

    Wong, Pak C.; Huang, Zhenyu; Chen, Yousu; Mackey, Patrick S.; Jin, Shuangshuang

    2014-01-20

    Contingency analysis is the process of employing different measures to model scenarios, analyze them, and then derive the best response to remove the threats. This application paper focuses on a class of contingency analysis problems found in the power grid management system. A power grid is a geographically distributed interconnected transmission network that transmits and delivers electricity from generators to end users. The power grid contingency analysis problem is increasingly important because of both the growing size of the underlying raw data that need to be analyzed and the urgency to deliver working solutions in an aggressive timeframe. Failure to do so may bring significant financial, economic, and security impacts to all parties involved and the society at large. The paper presents a scalable visual analytics pipeline that transforms about 100 million contingency scenarios to a manageable size and form for grid operators to examine different scenarios and come up with preventive or mitigation strategies to address the problems in a predictive and timely manner. Great attention is given to the computational scalability, information scalability, visual scalability, and display scalability issues surrounding the data analytics pipeline. Most of the large-scale computation requirements of our work are conducted on a Cray XMT multi-threaded parallel computer. The paper demonstrates a number of examples using western North American power grid models and data.

  2. Comparison of analytical eddy current models using principal components analysis

    NASA Astrophysics Data System (ADS)

    Contant, S.; Luloff, M.; Morelli, J.; Krause, T. W.

    2017-02-01

    Monitoring the gap between the pressure tube (PT) and the calandria tube (CT) in CANDU® fuel channels is essential, as contact between the two tubes can lead to delayed hydride cracking of the pressure tube. Multifrequency transmit-receive eddy current non-destructive evaluation is used to determine this gap, as this method has different depths of penetration and variable sensitivity to noise, unlike single frequency eddy current non-destructive evaluation. An Analytical model based on the Dodd and Deeds solutions, and a second model that accounts for normal and lossy self-inductances, and a non-coaxial pickup coil, are examined for representing the response of an eddy current transmit-receive probe when considering factors that affect the gap response, such as pressure tube wall thickness and pressure tube resistivity. The multifrequency model data was analyzed using principal components analysis (PCA), a statistical method used to reduce the data set into a data set of fewer variables. The results of the PCA of the analytical models were then compared to PCA performed on a previously obtained experimental data set. The models gave similar results under variable PT wall thickness conditions, but the non-coaxial coil model, which accounts for self-inductive losses, performed significantly better than the Dodd and Deeds model under variable resistivity conditions.

  3. Analytical Evaluation of Bit Error Rate Performance of a Free-Space Optical Communication System with Receive Diversity Impaired by Pointing Error

    NASA Astrophysics Data System (ADS)

    Nazrul Islam, A. K. M.; Majumder, S. P.

    2015-06-01

    Analysis is carried out to evaluate the conditional bit error rate conditioned on a given value of pointing error for a Free Space Optical (FSO) link with multiple receivers using Equal Gain Combining (EGC). The probability density function (pdf) of output signal to noise ratio (SNR) is also derived in presence of pointing error with EGC. The average BER of a SISO and SIMO FSO links are analytically evaluated by averaging the conditional BER over the pdf of the output SNR. The BER performance results are evaluated for several values of pointing jitter parameters and number of IM/DD receivers. The results show that, the FSO system suffers significant power penalty due to pointing error and can be reduced by increasing in the number of receivers at a given value of pointing error. The improvement of receiver sensitivity over SISO is about 4 dB and 9 dB when the number of photodetector is 2 and 4 at a BER of 10-10. It is also noticed that, system with receive diversity can tolerate higher value of pointing error at a given BER and transmit power.

  4. Finite Element Analysis of the LOLA Receiver Telescope Lens

    NASA Technical Reports Server (NTRS)

    Matzinger, Elizabeth

    2007-01-01

    This paper presents the finite element stress and distortion analysis completed on the Receiver Telescope lens of the Lunar Orbiter Laser Altimeter (LOLA). LOLA is one of six instruments on the Lunar Reconnaissance Orbiter (LRO), scheduled to launch in 2008. LOLA's main objective is to produce a high-resolution global lunar topographic model to aid in safe landings and enhance surface mobility in future exploration missions. The Receiver Telescope captures the laser pulses transmitted through a diffractive optical element (DOE) and reflected off the lunar surface. The largest lens of the Receiver Telescope, Lens 1, is a 150 mm diameter aspheric lens originally designed to be made of BK7 glass. The finite element model of the Receiver Telescope Lens 1 is comprised of solid elements and constrained in a manner consistent with the behavior of the mounting configuration of the Receiver Telescope tube. Twenty-one temperature load cases were mapped to the nodes based on thermal analysis completed by LOLA's lead thermal analyst, and loads were applied to simulate the preload applied from the ring flexure. The thermal environment of the baseline design (uncoated BK7 lens with no baffle) produces large radial and axial gradients in the lens. These large gradients create internal stresses that may lead to part failure, as well as significant bending that degrades optical performance. The high stresses and large distortions shown in the analysis precipitated a design change from BK7 glass to sapphire.

  5. Audience Analysis: A Programmed Approach to Receiver Behavior.

    ERIC Educational Resources Information Center

    Gibson, James W.; Hanna, Michael S.

    This branching programmed instructional workbook focuses on how people behave when they hear messages. Included are materials on audience/receiver behavior and a self-instructional supplement to materials that are a part of other communication studies. Drawings and diagrams illustrate the discussions of self-analysis, selection of audiences and…

  6. Superconducting integrated terahertz receiver for spectral analysis of gas compounds

    NASA Astrophysics Data System (ADS)

    Kinev, N. V.; Filippenko, L. V.; Kalashnikov, K. V.; Kiselev, O. S.; Vaks, V. L.; Domracheva, E. G.; Koshelets, V. P.

    2016-08-01

    A new highly sensitive device for analysis of gas compounds in terahertz frequency range based on the superconducting integrated receiver is being developed. Such receiver for spectral research of Earth atmosphere from balloon-borne instrument was developed earlier in Kotel'nikov Institute of Radio Engineering and Electronics and successfully operated during several flight missions. In this work, the laboratory setup for gas spectroscopy in the range of 450-700 GHz with the noise temperature below 150 K and spectral resolution better than 0.5 MHz is presented. First results of measurements of NH3 and H2O absorption spectra are obtained.

  7. UV Lidar Receiver Analysis for Tropospheric Sensing of Ozone

    NASA Technical Reports Server (NTRS)

    Pliutau, Denis; DeYoung, Russell J.

    2013-01-01

    A simulation of a ground based Ultra-Violet Differential Absorption Lidar (UV-DIAL) receiver system was performed under realistic daytime conditions to understand how range and lidar performance can be improved for a given UV pulse laser energy. Calculations were also performed for an aerosol channel transmitting at 3 W. The lidar receiver simulation studies were optimized for the purpose of tropospheric ozone measurements. The transmitted lidar UV measurements were from 285 to 295 nm and the aerosol channel was 527-nm. The calculations are based on atmospheric transmission given by the HITRAN database and the Modern Era Retrospective Analysis for Research and Applications (MERRA) meteorological data. The aerosol attenuation is estimated using both the BACKSCAT 4.0 code as well as data collected during the CALIPSO mission. The lidar performance is estimated for both diffuseirradiance free cases corresponding to nighttime operation as well as the daytime diffuse scattered radiation component based on previously reported experimental data. This analysis presets calculations of the UV-DIAL receiver ozone and aerosol measurement range as a function of sky irradiance, filter bandwidth and laser transmitted UV and 527-nm energy

  8. Single Cell Analysis of a Bacterial Sender-Receiver System

    PubMed Central

    Mückl, Andrea; Kapsner, Korbinian; Gerland, Ulrich; Simmel, Friedrich C.

    2016-01-01

    Monitoring gene expression dynamics on the single cell level provides important information on cellular heterogeneity and stochasticity, and potentially allows for more accurate quantitation of gene expression processes. We here study bacterial senders and receivers genetically engineered with components of the quorum sensing system derived from Aliivibrio fischeri on the single cell level using microfluidics-based bacterial chemostats and fluorescence video microscopy. We track large numbers of bacteria over extended periods of time, which allows us to determine bacterial lineages and filter out subpopulations within a heterogeneous population. We quantitatively determine the dynamic gene expression response of receiver bacteria to varying amounts of the quorum sensing inducer N-3-oxo-C6-homoserine lactone (AHL). From this we construct AHL response curves and characterize gene expression dynamics of whole bacterial populations by investigating the statistical distribution of gene expression activity over time. The bacteria are found to display heterogeneous induction behavior within the population. We therefore also characterize gene expression in a homogeneous bacterial subpopulation by focusing on single cell trajectories derived only from bacteria with similar induction behavior. The response at the single cell level is found to be more cooperative than that obtained for the heterogeneous total population. For the analysis of systems containing both AHL senders and receiver cells, we utilize the receiver cells as ‘bacterial sensors’ for AHL. Based on a simple gene expression model and the response curves obtained in receiver-only experiments, the effective AHL concentration established by the senders and their ‘sending power’ is determined. PMID:26808777

  9. Correlation analysis between ionospheric scintillation levels and receiver tracking performance

    NASA Astrophysics Data System (ADS)

    Sreeja, V.; Aquino, M.; Elmas, Z. G.; Forte, B.

    2012-06-01

    Rapid fluctuations in the amplitude and phase of a transionospheric radio signal caused by small scale plasma density irregularities in the ionosphere are known as scintillation. Scintillation can seriously impair a GNSS (Global Navigation Satellite Systems) receiver tracking performance, thus affecting the required levels of availability, accuracy and integrity, and consequently the reliability of modern day GNSS based applications. This paper presents an analysis of correlation between scintillation levels and tracking performance of a GNSS receiver for GPS L1C/A, L2C and GLONASS L1, L2 signals. The analyses make use of data recorded over Presidente Prudente (22.1°S, 51.4°W, dip latitude ˜12.3°S) in Brazil, a location close to the Equatorial Ionisation Anomaly (EIA) crest in Latin America. The study presents for the first time this type of correlation analysis for GPS L2C and GLONASS L1, L2 signals. The scintillation levels are defined by the amplitude scintillation index, S4 and the receiver tracking performance is evaluated by the phase tracking jitter. Both S4 and the phase tracking jitter are estimated from the post correlation In-Phase (I) and Quadra-Phase (Q) components logged by the receiver at a high rate. Results reveal that the dependence of the phase tracking jitter on the scintillation levels can be represented by a quadratic fit for the signals. The results presented in this paper are of importance to GNSS users, especially in view of the forthcoming high phase of solar cycle 24 (predicted for 2013).

  10. Mission Stream Analysis - Delta Analytic Model. Revision

    DTIC Science & Technology

    2014-09-01

    demonstrating mission effectiveness. The second tool is the  ( Delta ) Analytic Model, which provides an approach for identifying disparate...requirements into a system’s technical performance and operator workload requirements; and help minimize the “ delta ” between domains across the system’s...mission and system capability requirements into a system’s technical performance and operator workload requirements; and help minimize the “ delta

  11. Economic Risk Analysis: Using Analytical and Monte Carlo Techniques.

    ERIC Educational Resources Information Center

    O'Donnell, Brendan R.; Hickner, Michael A.; Barna, Bruce A.

    2002-01-01

    Describes the development and instructional use of a Microsoft Excel spreadsheet template that facilitates analytical and Monte Carlo risk analysis of investment decisions. Discusses a variety of risk assessment methods followed by applications of the analytical and Monte Carlo methods. Uses a case study to illustrate use of the spreadsheet tool…

  12. An overview on forensic analysis devoted to analytical chemists.

    PubMed

    Castillo-Peinado, L S; Luque de Castro, M D

    2017-05-15

    The present article has as main aim to show analytical chemists interested in forensic analysis the world they will face if decision in favor of being a forensic analytical chemist is adopted. With this purpose, the most outstanding aspects of forensic analysis in dealing with sampling (involving both bodily and no bodily samples), sample preparation, and analytical equipment used in detection, identification and quantitation of key sample components are critically discussed. The role of the great omics in forensic analysis, and the growing role of the youngest of the great omics -metabolomics- are also discussed. The foreseeable role of integrative omics is also outlined.

  13. Analytical analysis of particle-core dynamics

    SciTech Connect

    Batygin, Yuri K

    2010-01-01

    Particle-core interaction is a well-developed model of halo formation in high-intensity beams. In this paper, we present an analytical solution for averaged, single particle dynamics, around a uniformly charged beam. The problem is analyzed through a sequence of canonical transformations of the Hamiltonian, which describes nonlinear particle oscillations. A closed form expression for maximum particle deviation from the axis is obtained. The results of this study are in good agreement with numerical simulations and with previously obtained data.

  14. Receiver operating characteristic (ROC) analysis for characterizing synaptic efficacy.

    PubMed

    Chance, Frances S

    2007-02-01

    The role of background synaptic activity in cortical processing has recently received much attention. How do individual neurons extract information when embedded in a noisy background? When examining the impact of a synaptic input on postsynaptic firing, it is important to distinguish a change in overall firing probability from a true change in neuronal sensitivity to a particular input (synaptic efficacy) that corresponds to a change in detection performance. Here we study the impact of background synaptic input on neuronal sensitivity to individual synaptic inputs using receiver operating characteristic (ROC) analysis. We use the area under the ROC curve as a measure of synaptic efficacy, here defined as the ability of a postsynaptic action potential to identify a particular synaptic input event. An advantage of using ROC analysis to measure synaptic efficacy is that it provides a measure that is independent of postsynaptic firing rate. Furthermore, changes in mean excitation or inhibition, although affecting overall firing probability, do not modulate synaptic efficacy when measured in this way. Changes in overall conductance also affect firing probability but not this form of synaptic efficacy. Input noise, here defined as the variance of the input current, does modulate synaptic efficacy, however. This effect persists when the change in input variance is coupled with a change in conductance (as would result from changing background activity).

  15. Application and analysis of rake receiver to hybrid CPM modulation

    NASA Astrophysics Data System (ADS)

    Norris, James A.; Nieto, John W.

    2011-06-01

    Constant Envelope, Spread Spectrum Modulation is highly desirable for low-power, battery-operated systems. It has been demonstrated that Hybrid CPM is a constant envelope modulation with similar frequency diversity properties to the standard spread-spectrum m-PSK DSSS and spread-MSK modulation schemes while retaining a superior emissions profile. This paper continues the analysis of the novel constant envelope spread spectrum modulation technique with an analysis of the commonly utilized rake receiver signal processing. Initially, a simple channel model is developed to illustrate and compare the convergence of the channel estimate over a fixed, non-time-varying channel. A more complex, wireless channel model is then developed and a new corresponding method for channel estimation created. A Monte- Carlo simulated bit error rate performance of Hybrid CPM is then generated to evaluate the overall performance of the Hybrid CPM modulation scheme.

  16. Summative Mass Analysis of Algal Biomass - Integration of Analytical Procedures: Laboratory Analytical Procedure (LAP)

    SciTech Connect

    Laurens, L. M. L.

    2013-12-01

    This procedure guides the integration of laboratory analytical procedures to measure algal biomass constituents in an unambiguous manner and ultimately achieve mass balance closure for algal biomass samples. Many of these methods build on years of research in algal biomass analysis.

  17. Receive Mode Analysis and Design of Microstrip Reflectarrays

    NASA Technical Reports Server (NTRS)

    Rengarajan, Sembiam

    2011-01-01

    Traditionally microstrip or printed reflectarrays are designed using the transmit mode technique. In this method, the size of each printed element is chosen so as to provide the required value of the reflection phase such that a collimated beam results along a given direction. The reflection phase of each printed element is approximated using an infinite array model. The infinite array model is an excellent engineering approximation for a large microstrip array since the size or orientation of elements exhibits a slow spatial variation. In this model, the reflection phase from a given printed element is approximated by that of an infinite array of elements of the same size and orientation when illuminated by a local plane wave. Thus the reflection phase is a function of the size (or orientation) of the element, the elevation and azimuth angles of incidence of a local plane wave, and polarization. Typically, one computes the reflection phase of the infinite array as a function of several parameters such as size/orientation, elevation and azimuth angles of incidence, and in some cases for vertical and horizontal polarization. The design requires the selection of the size/orientation of the printed element to realize the required phase by interpolating or curve fitting all the computed data. This is a substantially complicated problem, especially in applications requiring a computationally intensive commercial code to determine the reflection phase. In dual polarization applications requiring rectangular patches, one needs to determine the reflection phase as a function of five parameters (dimensions of the rectangular patch, elevation and azimuth angles of incidence, and polarization). This is an extremely complex problem. The new method employs the reciprocity principle and reaction concept, two well-known concepts in electromagnetics to derive the receive mode analysis and design techniques. In the "receive mode design" technique, the reflection phase is computed

  18. Advanced Durability Analysis. Volume 1. Analytical Methods

    DTIC Science & Technology

    1987-07-31

    for microstruc .- tural behavior . This approach for representing the IFQ, when properly used, can provide reasonable durability analysis rt,- sults for...equivalent initial flaw size distribution (EIFSD) function. Engineering principles rather than mechanistic-based theories for microstructural behavior are...accurate EIFS distribution and a service crack growth behavior . The determinations of EIFS distribution have been described in detail previously. In this

  19. FASP, an analytic resource appraisal program for petroleum play analysis

    USGS Publications Warehouse

    Crovelli, R.A.; Balay, R.H.

    1986-01-01

    An analytic probabilistic methodology for resource appraisal of undiscovered oil and gas resources in play analysis is presented in a FORTRAN program termed FASP. This play-analysis methodology is a geostochastic system for petroleum resource appraisal in explored as well as frontier areas. An established geologic model considers both the uncertainty of the presence of the assessed hydrocarbon and its amount if present. The program FASP produces resource estimates of crude oil, nonassociated gas, dissolved gas, and gas for a geologic play in terms of probability distributions. The analytic method is based upon conditional probability theory and many laws of expectation and variance. ?? 1986.

  20. Risk analysis of analytical validations by probabilistic modification of FMEA.

    PubMed

    Barends, D M; Oldenhof, M T; Vredenbregt, M J; Nauta, M J

    2012-05-01

    Risk analysis is a valuable addition to validation of an analytical chemistry process, enabling not only detecting technical risks, but also risks related to human failures. Failure Mode and Effect Analysis (FMEA) can be applied, using a categorical risk scoring of the occurrence, detection and severity of failure modes, and calculating the Risk Priority Number (RPN) to select failure modes for correction. We propose a probabilistic modification of FMEA, replacing the categorical scoring of occurrence and detection by their estimated relative frequency and maintaining the categorical scoring of severity. In an example, the results of traditional FMEA of a Near Infrared (NIR) analytical procedure used for the screening of suspected counterfeited tablets are re-interpretated by this probabilistic modification of FMEA. Using this probabilistic modification of FMEA, the frequency of occurrence of undetected failure mode(s) can be estimated quantitatively, for each individual failure mode, for a set of failure modes, and the full analytical procedure.

  1. Analytic Perturbation Analysis of Discrete Event Dynamic Systems

    SciTech Connect

    Uryasev, S.

    1994-09-01

    This paper considers a new Analytic Perturbation Analysis (APA) approach for Discrete Event Dynamic Systems (DEDS) with discontinuous sample-path functions with respect to control parameters. The performance functions for DEDS usually are formulated as mathematical expectations, which can be calculated only numerically. APA is based on new analytic formulas for the gradients of expectations of indicator functions; therefore, it is called an analytic perturbation analysis. The gradient of performance function may not coincide with the expectation of a gradient of sample-path function (i.e., the interchange formula for the gradient and expectation sign may not be valid). Estimates of gradients can be obtained with one simulation run of the models.

  2. Analytical study of seismic effects of a solar receiver mounted on concrete towers with different fundamental periods

    NASA Astrophysics Data System (ADS)

    Deng, Lin

    2016-05-01

    This paper examines the seismic effects experienced by a solar receiver mounted on concrete towers with different fundamental periods. Ten concrete towers are modeled with the empty solar receiver structure and loaded solar receiver structure to examine the tower seismic effects on the solar receiver. The fundamental periods of the towers range from 0.22 seconds to 4.58 seconds, with heights ranging from 40.5 meters to 200 meters. Thirty earthquake ground motion records are used to investigate the responses of each of the combined receiver-on-tower models as well as the receiver-on-ground models by the STAAD Pro software using time history analyses. The earthquake ground motion records are chosen based on the ratio of the peak ground acceleration to the peak ground velocity, ranging from 0.29 g/m/s to 4.88 g/m/s. For each of the combined models, the base shear at the interface between the receiver and the concrete tower is compared with the base shear of the receiver-on-ground model, and the ratio of the two base shears represents the structure amplification factor. It is found that the peak mean plus one standard deviation value of the structure amplification factor matches well with equation 13.3-1 in ASCE 7-10 for the empty solar receiver structure. However, when the solar receiver structure is loaded with dead loads, the peak value is greatly suppressed, and using equation 13.3-1 in ASCE 7-10 will be overly conservative.

  3. Waste Analysis Plan for the Waste Receiving and Processing (WRAP) Facility

    SciTech Connect

    TRINER, G.C.

    1999-11-01

    The purpose of this waste analysis plan (WAP) is to document the waste acceptance process, sampling methodologies, analytical techniques, and overall processes that are undertaken for dangerous, mixed, and radioactive waste accepted for confirmation, nondestructive examination (NDE) and nondestructive assay (NDA), repackaging, certification, and/or storage at the Waste Receiving and Processing Facility (WRAP). Mixed and/or radioactive waste is treated at WRAP. WRAP is located in the 200 West Area of the Hanford Facility, Richland, Washington. Because dangerous waste does not include source, special nuclear, and by-product material components of mixed waste, radionuclides are not within the scope of this documentation. The information on radionuclides is provided only for general knowledge.

  4. Analytical and experimental analysis of tube coil heat exchanger

    NASA Astrophysics Data System (ADS)

    Smusz, R.

    2016-09-01

    The paper presents the analytical and experimental analysis of heat transfer for the finned tube coil heat exchanger immersed in thermal storage tank. The tank is equipped with three helical-shaped heating coils and cylindrical- shaped stratification device. Two coils, upper and lower, use the water as a heating medium. The third, double wall heat exchanger coil, located at the bottom head on the tank is filled by the refrigerant (freon). Calculations of thermal power of water coil were made. Correlations of heat transfer coefficients in curved tubes were applied. In order to verify the analytical calculations the experimental studies of heat transfer characteristic for coil heat exchanger were performed.

  5. An Analysis of Earth Science Data Analytics Use Cases

    NASA Technical Reports Server (NTRS)

    Shie, Chung-Lin; Kempler, Steve

    2014-01-01

    The increase in the number and volume, and sources, of globally available Earth science data measurements and datasets have afforded Earth scientists and applications researchers unprecedented opportunities to study our Earth in ever more sophisticated ways. In fact, the NASA Earth Observing System Data Information System (EOSDIS) archives have doubled from 2007 to 2014, to 9.1 PB (Ramapriyan, 2009; and https:earthdata.nasa.govaboutsystem-- performance). In addition, other US agency, international programs, field experiments, ground stations, and citizen scientists provide a plethora of additional sources for studying Earth. Co--analyzing huge amounts of heterogeneous data to glean out unobvious information is a daunting task. Earth science data analytics (ESDA) is the process of examining large amounts of data of a variety of types to uncover hidden patterns, unknown correlations and other useful information. It can include Data Preparation, Data Reduction, and Data Analysis. Through work associated with the Earth Science Information Partners (ESIP) Federation, a collection of Earth science data analytics use cases have been collected and analyzed for the purpose of extracting the types of Earth science data analytics employed, and requirements for data analytics tools and techniques yet to be implemented, based on use case needs. ESIP generated use case template, ESDA use cases, use case types, and preliminary use case analysis (this is a work in progress) will be presented.

  6. An Analysis of Earth Science Data Analytics Use Cases

    NASA Astrophysics Data System (ADS)

    Shie, C. L.; Kempler, S. J.

    2015-12-01

    The increase in the number and volume, and sources, of globally available Earth science data measurements and datasets have afforded Earth scientists and applications researchers unprecedented opportunities to study our Earth in ever more sophisticated ways. In fact, the NASA Earth Observing System Data Information System (EOSDIS) archives have doubled from 2007 to 2014, to 9.1 PB (Ramapriyan, 2009; and https://earthdata.nasa.gov/about/system-performance). In addition, other US agency, international programs, field experiments, ground stations, and citizen scientists provide a plethora of additional sources for studying Earth. Co-analyzing huge amounts of heterogeneous data to glean out unobvious information is a daunting task. Earth science data analytics (ESDA) is the process of examining large amounts of data of a variety of types to uncover hidden patterns, unknown correlations and other useful information. It can include Data Preparation, Data Reduction, and Data Analysis. Through work associated with the Earth Science Information Partners (ESIP) Federation, a collection of Earth science data analytics use cases have been collected and analyzed for the purpose of extracting the types of Earth science data analytics employed, and requirements for data analytics tools and techniques yet to be implemented, based on use case needs. ESIP generated use case template, ESDA use cases, use case types, and preliminary use case analysis (this is a work in progress) will be presented.

  7. Design and Analysis of a Hyperspectral Microwave Receiver Subsystem

    NASA Technical Reports Server (NTRS)

    Blackwell, W.; Galbraith, C.; Hancock, T.; Leslie, R.; Osaretin, I.; Shields, M.; Racette, P.; Hillard, L.

    2012-01-01

    Hyperspectral microwave (HM) sounding has been proposed to achieve unprecedented performance. HM operation is achieved using multiple banks of RF spectrometers with large aggregate bandwidth. A principal challenge is Size/Weight/Power scaling. Objectives of this work: 1) Demonstrate ultra-compact (100 cm3) 52-channel IF processor (enabler); 2) Demonstrate a hyperspectral microwave receiver subsystem; and 3) Deliver a flight-ready system to validate HM sounding.

  8. Optimization of Turbine Engine Cycle Analysis with Analytic Derivatives

    NASA Technical Reports Server (NTRS)

    Hearn, Tristan; Hendricks, Eric; Chin, Jeffrey; Gray, Justin; Moore, Kenneth T.

    2016-01-01

    A new engine cycle analysis tool, called Pycycle, was built using the OpenMDAO framework. Pycycle provides analytic derivatives allowing for an efficient use of gradient-based optimization methods on engine cycle models, without requiring the use of finite difference derivative approximation methods. To demonstrate this, a gradient-based design optimization was performed on a turbofan engine model. Results demonstrate very favorable performance compared to an optimization of an identical model using finite-difference approximated derivatives.

  9. High speed cylindrical rolling element bearing analysis 'CYBEAN' - Analytic formulation

    NASA Technical Reports Server (NTRS)

    Kleckner, R. J.; Pirvics, J.; Castelli, V.

    1979-01-01

    This paper documents the analytic foundation and software architecture for the computerized mathematical simulation of high speed cylindrical rolling element bearing behavior. The software, CYBEAN (CYlindrical BEaring ANalysis), considers a flexible, variable geometry outer ring, EHD films, roller centrifugal and quasidynamic loads, roller tilt and skew, mounting fits, cage and flange interactions. The representation includes both steady state and time transient simulation of thermal interactions internal to and coupled with the surroundings of the bearing. A sample problem illustrating program use is presented.

  10. Analysis of services received under Medicare by specialty of physician.

    PubMed

    Pine, P L; Gornick, M; Lubitz, J; Newton, M

    1981-09-01

    This paper examines use of physicians' services by Medicare beneficiaries according to the specialty of the physician providing care. The major objectives of this study were to determine which types of physicians are most frequently used, the average charge per service by specialty, the mix of physicians (by specialty) that patients saw during the year, and the amount Medicare reimburses in relation to total physician income. Data were studied for the total Medicare population and by age, sex, race, and geographic area. Claims data for 1975 and 1977 were used from the Part B Bill Summary System. This system collects information from bills from a 5 percent sample of Medicare enrollees. Major findings from this study indicate: (1) Physicians in general practice and internal medicine provided about the same number of services and each far outranked all other types of physicians in numbers of Medicare beneficiaries with reimbursed services. (2) There were marked differences by census region in the use of certain specialists, particularly pathologists, podiatrists, dermatologists, and the specialty group otology, laryngology, rhinology. (3) Average charges per service varied considerably by specialty. Internists' charges averaged 35 percent higher per service than charges by general practitioners. Charges submitted by the surgical specialties far outranked all others and showed the greatest increase during the period under study. (4) Of the total persons with reimbursement physicians' services in 1977, 85 percent saw a primary care physician during the year, while the remaining 15 percent received services from specialists only. (5) Of the total reimbursements made by Medicare, internists received 20 percent, general practitioners received 14 percent, and general surgeons 12 percent. Medicare's payments were estimated to be 21 percent of total gross income for internists, 20 percent for anesthesiologists, and 18 percent for surgical specialties.

  11. The performance analysis of linux networking - packet receiving

    SciTech Connect

    Wu, Wenji; Crawford, Matt; Bowden, Mark; /Fermilab

    2006-11-01

    The computing models for High-Energy Physics experiments are becoming ever more globally distributed and grid-based, both for technical reasons (e.g., to place computational and data resources near each other and the demand) and for strategic reasons (e.g., to leverage equipment investments). To support such computing models, the network and end systems, computing and storage, face unprecedented challenges. One of the biggest challenges is to transfer scientific data sets--now in the multi-petabyte (10{sup 15} bytes) range and expected to grow to exabytes within a decade--reliably and efficiently among facilities and computation centers scattered around the world. Both the network and end systems should be able to provide the capabilities to support high bandwidth, sustained, end-to-end data transmission. Recent trends in technology are showing that although the raw transmission speeds used in networks are increasing rapidly, the rate of advancement of microprocessor technology has slowed down. Therefore, network protocol-processing overheads have risen sharply in comparison with the time spent in packet transmission, resulting in degraded throughput for networked applications. More and more, it is the network end system, instead of the network, that is responsible for degraded performance of network applications. In this paper, the Linux system's packet receive process is studied from NIC to application. We develop a mathematical model to characterize the Linux packet receiving process. Key factors that affect Linux systems network performance are analyzed.

  12. Analysis of Cultural Heritage by Accelerator Techniques and Analytical Imaging

    NASA Astrophysics Data System (ADS)

    Ide-Ektessabi, Ari; Toque, Jay Arre; Murayama, Yusuke

    2011-12-01

    In this paper we present the result of experimental investigation using two very important accelerator techniques: (1) synchrotron radiation XRF and XAFS; and (2) accelerator mass spectrometry and multispectral analytical imaging for the investigation of cultural heritage. We also want to introduce a complementary approach to the investigation of artworks which is noninvasive and nondestructive that can be applied in situ. Four major projects will be discussed to illustrate the potential applications of these accelerator and analytical imaging techniques: (1) investigation of Mongolian Textile (Genghis Khan and Kublai Khan Period) using XRF, AMS and electron microscopy; (2) XRF studies of pigments collected from Korean Buddhist paintings; (3) creating a database of elemental composition and spectral reflectance of more than 1000 Japanese pigments which have been used for traditional Japanese paintings; and (4) visible light-near infrared spectroscopy and multispectral imaging of degraded malachite and azurite. The XRF measurements of the Japanese and Korean pigments could be used to complement the results of pigment identification by analytical imaging through spectral reflectance reconstruction. On the other hand, analysis of the Mongolian textiles revealed that they were produced between 12th and 13th century. Elemental analysis of the samples showed that they contained traces of gold, copper, iron and titanium. Based on the age and trace elements in the samples, it was concluded that the textiles were produced during the height of power of the Mongol empire, which makes them a valuable cultural heritage. Finally, the analysis of the degraded and discolored malachite and azurite demonstrates how multispectral analytical imaging could be used to complement the results of high energy-based techniques.

  13. Receiver Operating Characteristic Analysis for Detecting Explosives-related Threats

    SciTech Connect

    Oxley, Mark E; Venzin, Alexander M

    2012-11-14

    The Department of Homeland Security (DHS) and the Transportation Security Administration (TSA) are interested in developing a standardized testing procedure for determining the performance of candidate detection systems. This document outlines a potential method for judging detection system performance as well as determining if combining the information from a legacy system with a new system can signicantly improve performance. In this document, performance corresponds to the Neyman-Pearson criterion applied to the Receiver Operating Characteristic (ROC) curves of the detection systems in question. A simulation was developed to investigate how the amount of data provided by the vendor in the form of the ROC curve eects the performance of the combined detection system. Furthermore, the simulation also takes into account the potential eects of correlation and how this information can also impact the performance of the combined system.

  14. Central Andean crustal structure from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Ryan, Jamie; Beck, Susan; Zandt, George; Wagner, Lara; Minaya, Estela; Tavera, Hernado

    2016-07-01

    The Central Andean Plateau (15°-27°S) is a high plateau in excess of 3 km elevation, associated with thickened crust along the western edge of the South America plate, in the convergent margin between the subducting Nazca plate and the Brazilian craton. We have calculated receiver functions using seismic data from a recent portable deployment of broadband seismometers in the Bolivian orocline (12°-21°S) region and combined them with waveforms from 38 other stations in the region to investigate crustal thickness and crust and mantle structures. Results from the receiver functions provide a more detailed map of crustal thickness than previously existed, and highlight mid-crustal features that match well with prior studies. The active volcanic arc and Altiplano have thick crust with Moho depths increasing from the central Altiplano (65 km) to the northern Altiplano (75 km). The Eastern Cordillera shows large along strike variations in crustal thickness. Along a densely sampled SW-NE profile through the Bolivian orocline there is a small region of thin crust beneath the high peaks of the Cordillera Real where the average elevations are near 4 km, and the Moho depth varies from 55 to 60 km, implying the crust is undercompensated by 5 km. In comparison, a broader region of high elevations in the Eastern Cordillera to the southeast near 20°S has a deeper Moho at 65-70 km and appears close to isostatic equilibrium at the Moho. Assuming the modern-day pattern of high precipitation on the flanks of the Andean plateau has existed since the late Miocene, we suggest that climate induced exhumation can explain some of the variations in present day crustal structure across the Bolivian orocline. We also suggest that south of the orocline at 20°S, the thicker and isostatically compensated crust is due to the absence of erosional exhumation and the occurrence of lithospheric delamination.

  15. Paper-based analytical devices for environmental analysis.

    PubMed

    Meredith, Nathan A; Quinn, Casey; Cate, David M; Reilly, Thomas H; Volckens, John; Henry, Charles S

    2016-03-21

    The field of paper-based microfluidics has experienced rapid growth over the past decade. Microfluidic paper-based analytical devices (μPADs), originally developed for point-of-care medical diagnostics in resource-limited settings, are now being applied in new areas, such as environmental analyses. Low-cost paper sensors show great promise for on-site environmental analysis; the theme of ongoing research complements existing instrumental techniques by providing high spatial and temporal resolution for environmental monitoring. This review highlights recent applications of μPADs for environmental analysis along with technical advances that may enable μPADs to be more widely implemented in field testing.

  16. Optimization of Turbine Engine Cycle Analysis with Analytic Derivatives

    NASA Technical Reports Server (NTRS)

    Hearn, Tristan; Hendricks, Eric; Chin, Jeffrey; Gray, Justin; Moore, Kenneth T.

    2016-01-01

    A new engine cycle analysis tool, called Pycycle, was recently built using the OpenMDAO framework. This tool uses equilibrium chemistry based thermodynamics, and provides analytic derivatives. This allows for stable and efficient use of gradient-based optimization and sensitivity analysis methods on engine cycle models, without requiring the use of finite difference derivative approximation methods. To demonstrate this, a gradient-based design optimization was performed on a multi-point turbofan engine model. Results demonstrate very favorable performance compared to an optimization of an identical model using finite-difference approximated derivatives.

  17. Big Data Visual Analytics for Exploratory Earth System Simulation Analysis

    SciTech Connect

    Steed, Chad A.; Ricciuto, Daniel M.; Shipman, Galen M.; Smith, Brian E.; Thornton, Peter E.; Wang, Dali; Shi, Xiaoying; Williams, Dean N.

    2013-12-01

    Rapid increases in high performance computing are feeding the development of larger and more complex data sets in climate research, which sets the stage for so-called big data analysis challenges. However, conventional climate analysis techniques are inadequate in dealing with the complexities of today s data. In this paper, we describe and demonstrate a visual analytics system, called the Exploratory Data analysis ENvironment (EDEN), with specific application to the analysis of complex earth system simulation data sets. EDEN represents the type of interactive visual analysis tools that are necessary to transform data into insight, thereby improving critical comprehension of earth system processes. In addition to providing an overview of EDEN, we describe real-world studies using both point ensembles and global Community Land Model Version 4 (CLM4) simulations.

  18. An analytic method for sensitivity analysis of complex systems

    NASA Astrophysics Data System (ADS)

    Zhu, Yueying; Wang, Qiuping Alexandre; Li, Wei; Cai, Xu

    2017-03-01

    Sensitivity analysis is concerned with understanding how the model output depends on uncertainties (variances) in inputs and identifying which inputs are important in contributing to the prediction imprecision. Uncertainty determination in output is the most crucial step in sensitivity analysis. In the present paper, an analytic expression, which can exactly evaluate the uncertainty in output as a function of the output's derivatives and inputs' central moments, is firstly deduced for general multivariate models with given relationship between output and inputs in terms of Taylor series expansion. A γ-order relative uncertainty for output, denoted by Rvγ, is introduced to quantify the contributions of input uncertainty of different orders. On this basis, it is shown that the widely used approximation considering the first order contribution from the variance of input variable can satisfactorily express the output uncertainty only when the input variance is very small or the input-output function is almost linear. Two applications of the analytic formula are performed to the power grid and economic systems where the sensitivities of both actual power output and Economic Order Quantity models are analyzed. The importance of each input variable in response to the model output is quantified by the analytic formula.

  19. Risk analysis by FMEA as an element of analytical validation.

    PubMed

    van Leeuwen, J F; Nauta, M J; de Kaste, D; Odekerken-Rombouts, Y M C F; Oldenhof, M T; Vredenbregt, M J; Barends, D M

    2009-12-05

    We subjected a Near-Infrared (NIR) analytical procedure used for screening drugs on authenticity to a Failure Mode and Effects Analysis (FMEA), including technical risks as well as risks related to human failure. An FMEA team broke down the NIR analytical method into process steps and identified possible failure modes for each step. Each failure mode was ranked on estimated frequency of occurrence (O), probability that the failure would remain undetected later in the process (D) and severity (S), each on a scale of 1-10. Human errors turned out to be the most common cause of failure modes. Failure risks were calculated by Risk Priority Numbers (RPNs)=O x D x S. Failure modes with the highest RPN scores were subjected to corrective actions and the FMEA was repeated, showing reductions in RPN scores and resulting in improvement indices up to 5.0. We recommend risk analysis as an addition to the usual analytical validation, as the FMEA enabled us to detect previously unidentified risks.

  20. Learning Geospatial Analysis Skills with Consumer-Grade GPS Receivers and Low Cost Spatial Analysis Software

    ERIC Educational Resources Information Center

    Linehan, Peter E.

    2006-01-01

    Spatial analysis technologies are increasingly important tools for all aspects of forest resource management. Field work previously accomplished with map, compass, and engineers' scale is now being augmented, or superseded, by the use of GPS and GIS. Professional-grade GPS receivers and commercial GIS software are preferred for their accuracy and…

  1. Predictive factors in patients with hepatocellular carcinoma receiving sorafenib therapy using time-dependent receiver operating characteristic analysis

    PubMed Central

    Nishikawa, Hiroki; Nishijima, Norihiro; Enomoto, Hirayuki; Sakamoto, Azusa; Nasu, Akihiro; Komekado, Hideyuki; Nishimura, Takashi; Kita, Ryuichi; Kimura, Toru; Iijima, Hiroko; Nishiguchi, Shuhei; Osaki, Yukio

    2017-01-01

    Aims: To investigate variables before sorafenib therapy on the clinical outcomes in hepatocellular carcinoma (HCC) patients receiving sorafenib and to further assess and compare the predictive performance of continuous parameters using time-dependent receiver operating characteristics (ROC) analysis. Patients and methods: A total of 225 HCC patients were analyzed. We retrospectively examined factors related to overall survival (OS) and progression free survival (PFS) using univariate and multivariate analyses. Subsequently, we performed time-dependent ROC analysis of continuous parameters which were significant in the multivariate analysis in terms of OS and PFS. Total sum of area under the ROC in all time points (defined as TAAT score) in each case was calculated. Results: Our cohort included 175 male and 50 female patients (median age, 72 years) and included 158 Child-Pugh A and 67 Child-Pugh B patients. The median OS time was 0.68 years, while the median PFS time was 0.24 years. On multivariate analysis, gender, body mass index (BMI), Child-Pugh classification, extrahepatic metastases, tumor burden, aspartate aminotransferase (AST) and alpha-fetoprotein (AFP) were identified as significant predictors of OS and ECOG-performance status, Child-Pugh classification and extrahepatic metastases were identified as significant predictors of PFS. Among three continuous variables (i.e., BMI, AST and AFP), AFP had the highest TAAT score for the entire cohort. In subgroup analyses, AFP had the highest TAAT score except for Child-Pugh B and female among three continuous variables. Conclusion: In continuous variables, AFP could have higher predictive accuracy for survival in HCC patients undergoing sorafenib therapy. PMID:28261338

  2. Clinical analysis of cholangiocarcinoma patients receiving adjuvant radiotherapy

    PubMed Central

    Nantajit, Danupon; Trirussapanich, Pornwaree; Rojwatkarnjana, Sunanta; Soonklang, Kamonwan; Pattaranutraporn, Poompis; Laebua, Kanyanee; Chamchod, Sasikarn

    2016-01-01

    Cholangiocarcinoma (CCA) or bile duct cancer is a rare cancer type in developed countries, while its prevalence is increased in southeast Asia, affecting ~33.4 men and ~12.3 women per 100,000 individuals. CCA is one of the most lethal types of cancer. Neo-adjuvant and adjuvant therapies have been shown to have limited efficacy in improving the overall prognosis of patients. Radiotherapy has been reported to prolong the survival times of patients with certain characteristics. The present study retrospectively evaluated the medical records and follow-up data from 27 CCA patients who received radiotherapy at Chulabhorn Hospital (Bangkok, Thailand) between 2008 and 2014. A total of 14 patients underwent surgery followed by adjuvant chemoradiotherapy. Of the 27 CCA patients, 14 had intrahepatic CCA, 2 had extrahepatic CCA and 11 had hilar CCA. The 2-year survival rate was 40.7%. Tumor resectability, clinical symptoms and the Eastern Cooperative Oncology Group performance status score were found to be indicative of patient prognosis. In addition, the planning target volume and biologically effective radiotherapy dose were of prognostic value; however, initial treatment response was ambiguous in predicting survival time. The findings of the present study suggested that the currently used radiotherapy protocols for CCA may require modification to improve their efficacy. PMID:28105359

  3. Composable Analytic Systems for next-generation intelligence analysis

    NASA Astrophysics Data System (ADS)

    DiBona, Phil; Llinas, James; Barry, Kevin

    2015-05-01

    Lockheed Martin Advanced Technology Laboratories (LM ATL) is collaborating with Professor James Llinas, Ph.D., of the Center for Multisource Information Fusion at the University at Buffalo (State of NY), researching concepts for a mixed-initiative associate system for intelligence analysts to facilitate reduced analysis and decision times while proactively discovering and presenting relevant information based on the analyst's needs, current tasks and cognitive state. Today's exploitation and analysis systems have largely been designed for a specific sensor, data type, and operational context, leading to difficulty in directly supporting the analyst's evolving tasking and work product development preferences across complex Operational Environments. Our interactions with analysts illuminate the need to impact the information fusion, exploitation, and analysis capabilities in a variety of ways, including understanding data options, algorithm composition, hypothesis validation, and work product development. Composable Analytic Systems, an analyst-driven system that increases flexibility and capability to effectively utilize Multi-INT fusion and analytics tailored to the analyst's mission needs, holds promise to addresses the current and future intelligence analysis needs, as US forces engage threats in contested and denied environments.

  4. Facilitating the analysis of immunological data with visual analytic techniques.

    PubMed

    Shih, David C; Ho, Kevin C; Melnick, Kyle M; Rensink, Ronald A; Kollmann, Tobias R; Fortuno, Edgardo S

    2011-01-02

    Visual analytics (VA) has emerged as a new way to analyze large dataset through interactive visual display. We demonstrated the utility and the flexibility of a VA approach in the analysis of biological datasets. Examples of these datasets in immunology include flow cytometry, Luminex data, and genotyping (e.g., single nucleotide polymorphism) data. Contrary to the traditional information visualization approach, VA restores the analysis power in the hands of analyst by allowing the analyst to engage in real-time data exploration process. We selected the VA software called Tableau after evaluating several VA tools. Two types of analysis tasks analysis within and between datasets were demonstrated in the video presentation using an approach called paired analysis. Paired analysis, as defined in VA, is an analysis approach in which a VA tool expert works side-by-side with a domain expert during the analysis. The domain expert is the one who understands the significance of the data, and asks the questions that the collected data might address. The tool expert then creates visualizations to help find patterns in the data that might answer these questions. The short lag-time between the hypothesis generation and the rapid visual display of the data is the main advantage of a VA approach.

  5. Fully non-parametric receiver operating characteristic curve estimation for random-effects meta-analysis.

    PubMed

    Martínez-Camblor, Pablo

    2017-02-01

    Meta-analyses, broadly defined as the quantitative review and synthesis of the results of related but independent comparable studies, allow to know the state of the art of one considered topic. Since the amount of available bibliography has enhanced in almost all fields and, specifically, in biomedical research, its popularity has drastically increased during the last decades. In particular, different methodologies have been developed in order to perform meta-analytic studies of diagnostic tests for both fixed- and random-effects models. From a parametric point of view, these techniques often compute a bivariate estimation for the sensitivity and the specificity by using only one threshold per included study. Frequently, an overall receiver operating characteristic curve based on a bivariate normal distribution is also provided. In this work, the author deals with the problem of estimating an overall receiver operating characteristic curve from a fully non-parametric approach when the data come from a meta-analysis study i.e. only certain information about the diagnostic capacity is available. Both fixed- and random-effects models are considered. In addition, the proposed methodology lets to use the information of all cut-off points available (not only one of them) in the selected original studies. The performance of the method is explored through Monte Carlo simulations. The observed results suggest that the proposed estimator is better than the reference one when the reported information is related to a threshold based on the Youden index and when information for two or more points are provided. Real data illustrations are included.

  6. Gravity field error analysis: Applications of GPS receivers and gradiometers on low orbiting platforms

    NASA Technical Reports Server (NTRS)

    Schrama, E.

    1990-01-01

    The concept of a Global Positioning System (GPS) receiver as a tracking facility and a gradiometer as a separate instrument on a low orbiting platform offers a unique tool to map the Earth's gravitational field with unprecedented accuracies. The former technique allows determination of the spacecraft's ephemeris at any epoch to within 3 to 10 cm, the latter permits the measurement of the tensor of second order derivatives of the gravity field to within 0.01 to 0.0001 Eotvos units depending on the type of gradiometer. First, a variety of error sources in gradiometry where emphasis is placed on the rotational problem pursuing as well a static as a dynamic approach is described. Next, an analytical technique is described and applied for an error analysis of gravity field parameters from gradiometer and GPS observation types. Results are discussed for various configurations proposed on Topex/Poseidon, Gravity Probe-B, and Aristoteles, indicating that GPS only solutions may be computed up to degree and order 35, 55, and 85 respectively, whereas a combined GPS/gradiometer experiment on Aristoteles may result in an acceptable solution up to degree and order 240.

  7. Gravity field error analysis - Applications of Global Positioning System receivers and gradiometers on low orbiting platforms

    NASA Technical Reports Server (NTRS)

    Schrama, Ernst J. O.

    1991-01-01

    The concept of a Global Positioning System (GPS) receiver as a tracking facility and a gradiometer as a separate instrument on a low-orbiting platform offers a unique tool to map the earth's gravitational field with unprecedented accuracies. The former technique allows determination of the spacecraft's ephemeris at any epoch to within 3-10 cm, the latter permits the measurement of the tensor of second order derivatives of the gravity field to within 0.01 to 0.0001 Eotvos units depending on the type of gradiometer. First, a variety of error sources in gradiometry where emphasis is placed on the rotational problem pursuing as well a static as a dynamic approach is described. Next, an analytical technique is described and applied for an error analysis of gravity field parameters from gradiometer and GPS observation types. Results are discussed for various configurations proposed on Topex/Poseidon, Gravity Probe-B, and Aristoteles, indicating that GPS only solutions may be computed up to degree and order 35, 55, and 85, respectively, whereas a combined GPS/gradiometer experiment on Aristoteles may result in an acceptable solution up to degree and order 240.

  8. Gravity field error analysis - Applications of Global Positioning System receivers and gradiometers on low orbiting platforms

    NASA Astrophysics Data System (ADS)

    Schrama, Ernst J. O.

    1991-11-01

    The concept of a Global Positioning System (GPS) receiver as a tracking facility and a gradiometer as a separate instrument on a low-orbiting platform offers a unique tool to map the earth's gravitational field with unprecedented accuracies. The former technique allows determination of the spacecraft's ephemeris at any epoch to within 3-10 cm, the latter permits the measurement of the tensor of second order derivatives of the gravity field to within 0.01 to 0.0001 Eotvos units depending on the type of gradiometer. First, a variety of error sources in gradiometry where emphasis is placed on the rotational problem pursuing as well a static as a dynamic approach is described. Next, an analytical technique is described and applied for an error analysis of gravity field parameters from gradiometer and GPS observation types. Results are discussed for various configurations proposed on Topex/Poseidon, Gravity Probe-B, and Aristoteles, indicating that GPS only solutions may be computed up to degree and order 35, 55, and 85, respectively, whereas a combined GPS/gradiometer experiment on Aristoteles may result in an acceptable solution up to degree and order 240.

  9. Analysis and design methodology for the development of optimized, direct-detection CO{sub 2} DIAL receivers

    SciTech Connect

    Cooke, B.J.; Laubscher, B.E.; Cafferty, M.

    1996-12-31

    The analysis methodology and corresponding analytical tools for the design of optimized, low-noise, hard target return CO{sub 2} Differential Absorption Lidar (DIAL) receiver systems implementing both single element detectors and multi-pixel imaging arrays for passive/active, remote-sensing applications are presented. System parameters and components composing the receiver include: aperture, focal length, field of view, cold shield requirements, image plane dimensions, pixel dimensions, pixel pitch and fill factor, detection quantum efficiency, optical filter requirements, amplifier and temporal sampling parameters. The performance analysis is accomplished by calculating the system`s CO{sub 2} laser range response, total noise, optical geometric form factor and optical resolution. The noise components include speckle, photon noise due to signal, scene and atmospheric background, cold shield, and electronic noise. System resolution is simulated through cascaded optical transfer functions and includes effects due to atmosphere, optics, image sampling, and system motion. Experimental results of a developmental single-element detector receiver designed to detect 100 ns wide laser pulses (10 - 100 kHz pulse repetition rates) backscattered from hard-targets at nominal ranges of 10 km are presented. The receiver sensitivity is near-background noise limited, given an 8.5-11.5 {mu}m radiant optical bandwidth, with the total noise floor spectrally white for maximum pulse averaging efficiency.

  10. ANALYTICAL GALAXY PROFILES FOR PHOTOMETRIC AND LENSING ANALYSIS

    SciTech Connect

    Spergel, David N.

    2010-11-15

    This article introduces a family of analytical functions of the form x {sup {nu}} K {sub {nu}}(x), where K {sub {nu}} is the incomplete Bessel function of the third kind. This family of functions can describe the density profile, projected and integrated light profiles, and the gravitational potentials of galaxies. For the proper choice of parameters, these functions accurately approximate Sersic functions over a range of indices and are good fits to galaxy light profiles. With an additional parameter corresponding to a galaxy core radius, these functions can fit galaxy like M87 over a factor of 10{sup 5} in radius. Unlike Sersic profiles, these functions have simple analytical two-dimensional and three-dimensional Fourier transforms, so they are easily convolved with spatially varying point-spread function (PSF) and are well suited for photometric and lensing analysis. We use these functions to estimate the effects of seeing on lensing measurements and show that high S/N measurements, even when the PSF is larger than the galaxy effective radius, should be able to recover accurate estimates of lensing distortions by weighting light in the outer isophotes that are less affected by seeing.

  11. Physical and Chemical Analytical Analysis: A key component of Bioforensics

    SciTech Connect

    Velsko, S P

    2005-02-15

    The anthrax letters event of 2001 has raised our awareness of the potential importance of non-biological measurements on samples of biological agents used in a terrorism incident. Such measurements include a variety of mass spectral, spectroscopic, and other instrumental techniques that are part of the current armamentarium of the modern materials analysis or analytical chemistry laboratory. They can provide morphological, trace element, isotopic, and other molecular ''fingerprints'' of the agent that may be key pieces of evidence, supplementing that obtained from genetic analysis or other biological properties. The generation and interpretation of such data represents a new domain of forensic science, closely aligned with other areas of ''microbial forensics''. This paper describes some major elements of the R&D agenda that will define this sub-field in the immediate future and provide the foundations for a coherent national capability. Data from chemical and physical analysis of BW materials can be useful to an investigation of a bio-terror event in two ways. First, it can be used to compare evidence samples collected at different locations where such incidents have occurred (e.g. between the powders in the New York and Washington letters in the Amerithrax investigation) or between the attack samples and those seized during the investigation of sites where it is suspected the material was manufactured (if such samples exist). Matching of sample properties can help establish the relatedness of disparate incidents, and mis-matches might exclude certain scenarios, or signify a more complex etiology of the events under investigation. Chemical and morphological analysis for sample matching has a long history in forensics, and is likely to be acceptable in principle in court, assuming that match criteria are well defined and derived from known limits of precision of the measurement techniques in question. Thus, apart from certain operational issues (such as how to

  12. Automating the analytical laboratory via the Chemical Analysis Automation paradigm

    SciTech Connect

    Hollen, R.; Rzeszutko, C.

    1997-10-01

    To address the need for standardization within the analytical chemistry laboratories of the nation, the Chemical Analysis Automation (CAA) program within the US Department of Energy, Office of Science and Technology`s Robotic Technology Development Program is developing laboratory sample analysis systems that will automate the environmental chemical laboratories. The current laboratory automation paradigm consists of islands-of-automation that do not integrate into a system architecture. Thus, today the chemist must perform most aspects of environmental analysis manually using instrumentation that generally cannot communicate with other devices in the laboratory. CAA is working towards a standardized and modular approach to laboratory automation based upon the Standard Analysis Method (SAM) architecture. Each SAM system automates a complete chemical method. The building block of a SAM is known as the Standard Laboratory Module (SLM). The SLM, either hardware or software, automates a subprotocol of an analysis method and can operate as a standalone or as a unit within a SAM. The CAA concept allows the chemist to easily assemble an automated analysis system, from sample extraction through data interpretation, using standardized SLMs without the worry of hardware or software incompatibility or the necessity of generating complicated control programs. A Task Sequence Controller (TSC) software program schedules and monitors the individual tasks to be performed by each SLM configured within a SAM. The chemist interfaces with the operation of the TSC through the Human Computer Interface (HCI), a logical, icon-driven graphical user interface. The CAA paradigm has successfully been applied in automating EPA SW-846 Methods 3541/3620/8081 for the analysis of PCBs in a soil matrix utilizing commercially available equipment in tandem with SLMs constructed by CAA.

  13. Focused analyte spray emission apparatus and process for mass spectrometric analysis

    DOEpatents

    Roach, Patrick J [Kennewick, WA; Laskin, Julia [Richland, WA; Laskin, Alexander [Richland, WA

    2012-01-17

    An apparatus and process are disclosed that deliver an analyte deposited on a substrate to a mass spectrometer that provides for trace analysis of complex organic analytes. Analytes are probed using a small droplet of solvent that is formed at the junction between two capillaries. A supply capillary maintains the droplet of solvent on the substrate; a collection capillary collects analyte desorbed from the surface and emits analyte ions as a focused spray to the inlet of a mass spectrometer for analysis. The invention enables efficient separation of desorption and ionization events, providing enhanced control over transport and ionization of the analyte.

  14. A Double Scattering Analytical Model For Elastic Recoil Detection Analysis

    SciTech Connect

    Barradas, N. P.; Lorenz, K.; Alves, E.; Darakchieva, V.

    2011-06-01

    We present an analytical model for calculation of double scattering in elastic recoil detection measurements. Only events involving the beam particle and the recoil are considered, i.e. 1) an ion scatters off a target element and then produces a recoil, and 2) an ion produces a recoil which then scatters off a target element. Events involving intermediate recoils are not considered, i.e. when the primary ion produces a recoil which then produces a second recoil. If the recoil element is also present in the stopping foil, recoil events in the stopping foil are also calculated. We included the model in the standard code for IBA data analysis NDF, and applied it to the measurement of hydrogen in Si.

  15. A Visual Analytics Approach for Correlation, Classification, and Regression Analysis

    SciTech Connect

    Steed, Chad A; SwanII, J. Edward; Fitzpatrick, Patrick J.; Jankun-Kelly, T.J.

    2012-02-01

    New approaches that combine the strengths of humans and machines are necessary to equip analysts with the proper tools for exploring today's increasing complex, multivariate data sets. In this paper, a novel visual data mining framework, called the Multidimensional Data eXplorer (MDX), is described that addresses the challenges of today's data by combining automated statistical analytics with a highly interactive parallel coordinates based canvas. In addition to several intuitive interaction capabilities, this framework offers a rich set of graphical statistical indicators, interactive regression analysis, visual correlation mining, automated axis arrangements and filtering, and data classification techniques. The current work provides a detailed description of the system as well as a discussion of key design aspects and critical feedback from domain experts.

  16. A Visual Analytics Approach for Correlation, Classification, and Regression Analysis

    SciTech Connect

    Steed, Chad A; SwanII, J. Edward; Fitzpatrick, Patrick J.; Jankun-Kelly, T.J.

    2013-01-01

    New approaches that combine the strengths of humans and machines are necessary to equip analysts with the proper tools for exploring today s increasing complex, multivariate data sets. In this paper, a visual data mining framework, called the Multidimensional Data eXplorer (MDX), is described that addresses the challenges of today s data by combining automated statistical analytics with a highly interactive parallel coordinates based canvas. In addition to several intuitive interaction capabilities, this framework offers a rich set of graphical statistical indicators, interactive regression analysis, visual correlation mining, automated axis arrangements and filtering, and data classification techniques. This chapter provides a detailed description of the system as well as a discussion of key design aspects and critical feedback from domain experts.

  17. Analytical framework for recurrence network analysis of time series.

    PubMed

    Donges, Jonathan F; Heitzig, Jobst; Donner, Reik V; Kurths, Jürgen

    2012-04-01

    Recurrence networks are a powerful nonlinear tool for time series analysis of complex dynamical systems. While there are already many successful applications ranging from medicine to paleoclimatology, a solid theoretical foundation of the method has still been missing so far. Here, we interpret an ɛ-recurrence network as a discrete subnetwork of a "continuous" graph with uncountably many vertices and edges corresponding to the system's attractor. This step allows us to show that various statistical measures commonly used in complex network analysis can be seen as discrete estimators of newly defined continuous measures of certain complex geometric properties of the attractor on the scale given by ɛ. In particular, we introduce local measures such as the ɛ-clustering coefficient, mesoscopic measures such as ɛ-motif density, path-based measures such as ɛ-betweennesses, and global measures such as ɛ-efficiency. This new analytical basis for the so far heuristically motivated network measures also provides an objective criterion for the choice of ɛ via a percolation threshold, and it shows that estimation can be improved by so-called node splitting invariant versions of the measures. We finally illustrate the framework for a number of archetypical chaotic attractors such as those of the Bernoulli and logistic maps, periodic and two-dimensional quasiperiodic motions, and for hyperballs and hypercubes by deriving analytical expressions for the novel measures and comparing them with data from numerical experiments. More generally, the theoretical framework put forward in this work describes random geometric graphs and other networks with spatial constraints, which appear frequently in disciplines ranging from biology to climate science.

  18. A New Analytic Framework for Moderation Analysis --- Moving Beyond Analytic Interactions

    PubMed Central

    Tang, Wan; Yu, Qin; Crits-Christoph, Paul; Tu, Xin M.

    2009-01-01

    Conceptually, a moderator is a variable that modifies the effect of a predictor on a response. Analytically, a common approach as used in most moderation analyses is to add analytic interactions involving the predictor and moderator in the form of cross-variable products and test the significance of such terms. The narrow scope of such a procedure is inconsistent with the broader conceptual definition of moderation, leading to confusion in interpretation of study findings. In this paper, we develop a new approach to the analytic procedure that is consistent with the concept of moderation. The proposed framework defines moderation as a process that modifies an existing relationship between the predictor and the outcome, rather than simply a test of a predictor by moderator interaction. The approach is illustrated with data from a real study. PMID:20161453

  19. Design and analysis of a novel concentrated photovoltaic-thermal receiver concept

    NASA Astrophysics Data System (ADS)

    Hangweirer, Manfred; Höller, Robert; Schneider, Hartmut

    2015-08-01

    Solar concentrators, which focus the sunlight on a small surface of solar cells, are a promising way of reducing expensive semiconductor area and thus also the energy generation costs of photovoltaics. This paper presents the design and the analysis of a concentrated photovoltaic (CPV) receiver for a linear Fresnel concentrator mirror module. The receiver is designed as hybrid concentrated photovoltaic-thermal (CPV-T) receiver, which enables simultaneous generation of power and heat in one compact receiver. Spectral splitting with selective absorptive media and thermal decoupling of heat carrier and solar cells improves the electrical efficiency. Computational fluid dynamics (CFD) simulations of various receiver-setups result in an electrical efficiency of the receiver up to 6.2% and a thermal efficiency of up to 61.2% at a specific selected operating design point. 62% of the wavelengths of the incoming solar spectrum between 500 to 1100 nm hit the solar cells.

  20. An analytical paradigm for the analysis of national inmigration patterns.

    PubMed

    Weisberg, Y; Eaglstein, A S

    1988-09-01

    This study proposes and demonstrates an analytic paradigm based upon a substantive categorization of a set of inmigration correlates. It exemplifies the notion of categorizing, analyzing according to the categorization, and subsequently discussing the phenomenon in more depth. The paradigm has 2 steps: 1) the variables are categorized according to the cells resulting from the intersection of a preferably small number of nominal dimensions and 2) the data are analyzed, directly anchored in the prior categorization. The data used is Israel's 1983 census macro-data gathered from the Central Bureau of Statistics for the Israeli towns with populations of at least 5000. The authors defined 6 variables as push variables and 4 as pull variables. Results of the regression employing push variables show that 4 variables accounting for 72% of inmigration were found to significantly predict inmigration: 1) unemployment, 2) percentage of Asians-Africans, 3) town size, and 4) religiosity. Within the pull classification, the regression analysis reveals that 2 of the 4 variables explain 31% of the inmigration variance: 1) educational level (26%) and 2) income (5%). The 1st regression analysis on the 2nd dimension shows that the percentage of Asian-African origin and town population size account for 32% of the immigration variance. In the 2nd regression analysis, unemployment explains 48% of the inmigration variance and educational level explains 8%. In the 3rd regression, only home crowding explains a significant amount of the immigration variance (19%). Results of a multiple regression analysis show that unemployment level, percentage of Asian-Africans, population size, and level of religiosity account for 72% of the inmigration variance. Thus, the characteristics of a town inmigrating (push variables) are demographic, economic, and social. However, the attractive features of a town are only economic. Among all economic factors, unemployment is primary. In addition, not only are

  1. Thermal stress analysis of eccentric tube receiver using concentrated solar radiation

    SciTech Connect

    Wang, Fuqiang; Shuai, Yong; Yuan, Yuan; Yang, Guo; Tan, Heping

    2010-10-15

    In the parabolic trough concentrator with tube receiver system, the heat transfer fluid flowing through the tube receiver can induce high thermal stress and deflection. In this study, the eccentric tube receiver is introduced with the aim to reduce the thermal stresses of tube receiver. The ray-thermal-structural sequential coupled numerical analyses are adopted to obtain the concentrated heat flux distributions, temperature distributions and thermal stress fields of both the eccentric and concentric tube receivers. During the sequential coupled numerical analyses, the concentrated heat flux distribution on the bottom half periphery of tube receiver is obtained by Monte-Carlo ray tracing method, and the fitting function method is introduced for the calculated heat flux distribution transformation from the Monte-Carlo ray tracing model to the CFD analysis model. The temperature distributions and thermal stress fields are obtained by the CFD and FEA analyses, respectively. The effects of eccentricity and oriented angle variation on the thermal stresses of eccentric tube receiver are also investigated. It is recommended to adopt the eccentric tube receiver with optimum eccentricity and 90 oriented angle as tube receiver for the parabolic trough concentrator system to reduce the thermal stresses. (author)

  2. Dairy Analytics and Nutrient Analysis (DANA) Prototype System User Manual

    SciTech Connect

    Sam Alessi; Dennis Keiser

    2012-10-01

    This document is a user manual for the Dairy Analytics and Nutrient Analysis (DANA) model. DANA provides an analysis of dairy anaerobic digestion technology and allows users to calculate biogas production, co-product valuation, capital costs, expenses, revenue and financial metrics, for user customizable scenarios, dairy and digester types. The model provides results for three anaerobic digester types; Covered Lagoons, Modified Plug Flow, and Complete Mix, and three main energy production technologies; electricity generation, renewable natural gas generation, and compressed natural gas generation. Additional options include different dairy types, bedding types, backend treatment type as well as numerous production, and economic parameters. DANA’s goal is to extend the National Market Value of Anaerobic Digester Products analysis (informa economics, 2012; Innovation Center, 2011) to include a greater and more flexible set of regional digester scenarios and to provide a modular framework for creation of a tool to support farmer and investor needs. Users can set up scenarios from combinations of existing parameters or add new parameters, run the model and view a variety of reports, charts and tables that are automatically produced and delivered over the web interface. DANA is based in the INL’s analysis architecture entitled Generalized Environment for Modeling Systems (GEMS) , which offers extensive collaboration, analysis, and integration opportunities and greatly speeds the ability construct highly scalable web delivered user-oriented decision tools. DANA’s approach uses server-based data processing and web-based user interfaces, rather a client-based spreadsheet approach. This offers a number of benefits over the client-based approach. Server processing and storage can scale up to handle a very large number of scenarios, so that analysis of county, even field level, across the whole U.S., can be performed. Server based databases allow dairy and digester

  3. CFD analysis of supercritical CO2 used as HTF in a solar tower receiver

    NASA Astrophysics Data System (ADS)

    Roldán, M. I.; Fernández-Reche, J.

    2016-05-01

    The relative cost of a solar receiver can be minimized by the selection of an appropriate heat transfer fluid capable of achieving high receiver efficiencies. In a conventional central receiver system, the concentrated solar energy is transferred from the receiver tube walls to the heat transfer fluid (HTF), which passes through a heat exchanger to generate steam for a Rankine cycle. Thus, higher working fluid temperature is associated with greater efficiency in receiver and power cycle. Emerging receiver designs that can enable higher efficiencies using advanced power cycles, such as supercritical CO2 (s-CO2) closed-loop Brayton cycles, include direct heating of s-CO2 in tubular receiver designs capable of withstanding high internal fluid pressures (around 20 MPa) and temperatures (900 K). Due to the high pressures required and the presence of moving components installed in pipelines (ball-joints and/or flexible connections), the use of s-CO2 presents many technical challenges due to the compatibility of seal materials and fluid leakages of the moving connections. These problems are solved in solar tower systems because the receiver is fixed. In this regard, a preliminary analysis of a tubular receiver with s-CO2 as HTF has been developed using the design of a molten-salt receiver which was previously tested at Plataforma Solar de Almería (PSA). Therefore, a simplified CFD model has been carried out in this study in order to analyze the feasibility of s-CO2 as HTF in solar towers. Simulation results showed that the heat gained by s-CO2 was around 75% greater than the one captured by molten salts (fluid inlet temperature of 715 K), but at a pressure range of 7.5-9.7 MPa. Thus, the use of s-CO2 as HTF in solar tower receivers appears to be a promising alternative, taking into account both the operating conditions required and their maintenance cost.

  4. Cross-correlation analysis and interpretation of spaced-receiver measurements

    NASA Astrophysics Data System (ADS)

    Costa, Emanoel; Fougere, Paul F.; Basu, Santimay

    1988-04-01

    The results of two algorithms which provide a statistical treatment of the estimation parameters in the cross-correlation analysis of spaced-receiver data are compared. The observations are found to be consistent with a previous morphological model for anisotropy of high latitude nighttime F region irregularities. It is suggested that a possible dependence of the results of the spaced-receiver measurements on the receiver baselines may be responsible for the relatively small values of the anisotropy of the diffraction pattern noted in Hilat satellite measurements. A procedure for estimating the anisotropy of the in situ irregularities from the anisotropy of the diffraction pattten is proposed.

  5. Performance analysis and receiver architectures of DCF77 radio-controlled clocks.

    PubMed

    Engeler, Daniel

    2012-05-01

    DCF77 is a longwave radio transmitter located in Germany. Atomic clocks generate a 77.5-kHz carrier which is amplitude- and phase-modulated to broadcast the official time. The signal is used by industrial and consumer radio-controlled clocks. DCF77 faces competition from the Global Positioning System (GPS) which provides higher accuracy time. Still, DCF77 and other longwave time services worldwide remain popular because they allow indoor reception at lower cost, lower power, and sufficient accuracy. Indoor longwave reception is challenged by signal attenuation and electromagnetic interference from an increasing number of devices, particularly switched-mode power supplies. This paper introduces new receiver architectures and compares them with existing detectors and time decoders. Simulations and analytical calculations characterize the performance in terms of bit error rate and decoding probability, depending on input noise and narrowband interference. The most promising detector with maximum-likelihood time decoder displays the time in less than 60 s after powerup and at a noise level of E(b)/N(0) = 2.7 dB, an improvement of 20 dB over previous receivers. A field-programmable gate array-based demonstration receiver built for the purposes of this paper confirms the capabilities of these new algorithms. The findings of this paper enable future high-performance DCF77 receivers and further study of indoor longwave reception.

  6. Performance enhancement of rake-receiver using continuous and discrete wavelet transforms analysis through NLOS propagation

    NASA Astrophysics Data System (ADS)

    Fayadh, Rashid A.; Malek, F.; Fadhil, Hilal A.; Dawood, Sameer A.; Abdullah, Farah Salwani

    2015-05-01

    In this paper, three levels of analysis and synthesis filter banks were used to create coefficients for a continuous wavelet transform (CWT) and discrete wavelet transform (DWT). The main property of these wavelet transform schemes is their ability to construct the transmitted signal across a log-normal fading channel over additive white Gaussian noise (AWGN). Wireless rake-receiver structure was chosen as a major application to reduce the inter-symbol interference (ISI) and to minimize the noise. In this work, a new scheme of rake receiver is proposed to receive indoor, multi-path components (MPCs) for ultra-wideband (UWB) wireless communication systems. Rake receivers consist of a continuous wavelet rake (CW-rake) and a discrete wavelet rake (DW-rake), and they use huge bandwidth (7.5 GHz), as reported by the Federal Communications Commission (FCC). The indoor channel models chose for analysis in this research were the non line-of-sight (LOS) channel model (CM4 from 4 to 10 meters) to show the behavior of bit error rate (BER) with respect to signal-to noise ratio (SNR). Two types of rake receiver were used in the simulation, i.e., partial-rake and selective-rake receivers with the maximal ratio combining (MRC) technique to capture the energy of the signal from the output of the rake's fingers.

  7. Thermodynamic Analysis of Beam down Solar Gas Turbine Power Plant equipped with Concentrating Receiver System

    NASA Astrophysics Data System (ADS)

    Azharuddin; Santarelli, Massimo

    2016-09-01

    Thermodynamic analysis of a closed cycle, solar powered Brayton gas turbine power plant with Concentrating Receiver system has been studied. A Brayton cycle is simpler than a Rankine cycle and has an advantage where the water is scarce. With the normal Brayton cycle a Concentrating Receiver System has been analysed which has a dependence on field density and optical system. This study presents a method of optimization of design parameter, such as the receiver working temperature and the heliostats density. This method aims at maximizing the overall efficiency of the three major subsystem that constitute the entire plant, namely, the heliostat field and the tower, the receiver and the power block. The results of the optimization process are shown and analysed.

  8. Analytical studies: a framework for quality improvement design and analysis.

    PubMed

    Provost, Lloyd P

    2011-04-01

    Conducting studies for learning is fundamental to improvement. Deming emphasised that the reason for conducting a study is to provide a basis for action on the system of interest. He classified studies into two types depending on the intended target for action. An enumerative study is one in which action will be taken on the universe that was studied. An analytical study is one in which action will be taken on a cause system to improve the future performance of the system of interest. The aim of an enumerative study is estimation, while an analytical study focuses on prediction. Because of the temporal nature of improvement, the theory and methods for analytical studies are a critical component of the science of improvement.

  9. Applications of nuclear analytical methods to materials analysis

    SciTech Connect

    Jones, K.W.; Hanson, A.L.; Kraner, H.W.

    1982-01-01

    Nuclear analytical methods have now become important in the characterization of many types of materials and have been shown to be an extremely important extension of many more common methods. To illustrate the breadth of their use, some recent Brookhaven experiments are described that deal with the depth distribution of hydrogen in Nb-H alloys, the diffusion of Mo in graphite at high temperatures, and the measurement of Al and Si concentrations in zeolite catalysts. It is hoped that the presentation of these illustrative examples will serve as a stimulus and encouragement for the further application of nuclear analytical methods.

  10. An experimental analysis of a doped lithium fluoride direct absorption solar receiver

    NASA Technical Reports Server (NTRS)

    Kesseli, James; Pollak, Tom; Lacy, Dovie

    1988-01-01

    An experimental analysis of two key elements of a direct absorption solar receiver for use with Brayton solar dynamic systems was conducted. Experimental data are presented on LiF crystals doped with dysprosium, samarium, and cobalt fluorides. In addition, a simulation of the cavity/window environment was performed and a posttest inspection was conducted to evaluate chemical reactivity, transmissivity, and condensation rate.

  11. Applying Bayesian Modeling and Receiver Operating Characteristic Methodologies for Test Utility Analysis

    ERIC Educational Resources Information Center

    Wang, Qiu; Diemer, Matthew A.; Maier, Kimberly S.

    2013-01-01

    This study integrated Bayesian hierarchical modeling and receiver operating characteristic analysis (BROCA) to evaluate how interest strength (IS) and interest differentiation (ID) predicted low–socioeconomic status (SES) youth's interest-major congruence (IMC). Using large-scale Kuder Career Search online-assessment data, this study fit three…

  12. Power and Efficiency Analysis of a Solar Central Receiver Combined Cycle Plant with a Small Particle Heat Exchanger Receiver

    NASA Astrophysics Data System (ADS)

    Virgen, Matthew Miguel

    Two significant goals in solar plant operation are lower cost and higher efficiencies. To achieve those goals, a combined cycle gas turbine (CCGT) system, which uses the hot gas turbine exhaust to produce superheated steam for a bottoming Rankine cycle by way of a heat recovery steam generator (HRSG), is investigated in this work. Building off of a previous gas turbine model created at the Combustion and Solar Energy Laboratory at SDSU, here are added the HRSG and steam turbine model, which had to handle significant change in the mass flow and temperature of air exiting the gas turbine due to varying solar input. A wide range of cases were run to explore options for maximizing both power and efficiency from the proposed CSP CCGT plant. Variable guide vanes (VGVs) were found in the earlier model to be an effective tool in providing operational flexibility to address the variable nature of solar input. Combined cycle efficiencies in the range of 50% were found to result from this plant configuration. However, a combustor inlet temperature (CIT) limit leads to two distinct Modes of operation, with a sharp drop in both plant efficiency and power occurring when the air flow through the receiver exceeded the CIT limit. This drawback can be partially addressed through strategic use of the VGVs. Since system response is fully established for the relevant range of solar input and variable guide vane angles, the System Advisor Model (SAM) from NREL can be used to find what the actual expected solar input would be over the course of the day, and plan accordingly. While the SAM software is not yet equipped to model a Brayton cycle cavity receiver, appropriate approximations were made in order to produce a suitable heliostat field to fit this system. Since the SPHER uses carbon nano-particles as the solar absorbers, questions of particle longevity and how the particles might affect the flame behavior in the combustor were addressed using the chemical kinetics software Chemkin

  13. An Analysis of the Effects of RFID Tags on Narrowband Navigation and Communication Receivers

    NASA Technical Reports Server (NTRS)

    LaBerge, E. F. Charles

    2007-01-01

    The simulated effects of the Radio Frequency Identification (RFID) tag emissions on ILS Localizer and ILS Glide Slope functions match the analytical models developed in support of DO-294B provided that the measured peak power levels are adjusted for 1) peak-to-average power ratio, 2) effective duty cycle, and 3) spectrum analyzer measurement bandwidth. When these adjustments are made, simulated and theoretical results are in extraordinarily good agreement. The relationships hold over a large range of potential interference-to-desired signal power ratios, provided that the adjusted interference power is significantly higher than the sum of the receiver noise floor and the noise-like contributions of all other interference sources. When the duty-factor adjusted power spectral densities are applied in the evaluation process described in Section 6 of DO-294B, most narrowband guidance and communications radios performance parameters are unaffected by moderate levels of RFID interference. Specific conclusions and recommendations are provided.

  14. Advanced Durability Analysis. Volume 2. Analytical Predictions, Test Results and Analytical Correlations

    DTIC Science & Technology

    1989-02-27

    used for the back-extrapolation. Recommendations for durability analysis are as follows: (1) define the equivalent initial flaw size distribution ...WAFXHR4 Data Set) for Cumulative Distribution of Service Time to Reach Crack Size x1 -0.59" Based on DCGA- DCGA. xiv List of Figures (Continued) Fiaur. ag ...be used to make predictions for the probability bf crack exceedance at any service time, 7’ , and the cumulative distribution of service time to

  15. Solar power generation by use of Stirling engine and heat loss analysis of its cavity receiver

    NASA Astrophysics Data System (ADS)

    Hussain, Tassawar

    position (AP=H/D) were used to characterize the different configurations of Cavity Receiver and it was found that the Cavity Receiver with AR=0.5 and AP=0.53 has the maximum capability to utilize the solar heat to attain the maximum temperature of the heat pipe receiver. Experimental heat loss analysis at low temperature for different configurations of the cavity receiver was performed and air film temperature profiles along the wall height (H) of the cavity receiver were determined. Since sodium heat pipes operate at high temperature (973K), there are huge possibilities of radiation and convection heat losses for direct solar heating of the heater head. Therefore mathematical modeling of heat loss analysis and its numerical solution at high temperature was also included in the research objectives. 2-D axisymmetric model with weakly compressible Navier Stokes equation and general heat conduction and convection equations were simultaneously solved using the finite element method approach. Computational fluid dynamics package COMSOL 3.5a was used as a numerical tool. The temperature, and flow field pattern inside the cavity receiver were also visualized by means of surface contours. Heat loss analysis were performed for different configurations of Cavity Receiver and the numerical solution of different configuration showed that the aperture ratio (AR) plays a significant role for convection and radiation heat losses whereas the aperture position (AP) effects are negligible.

  16. Path integral analysis of Jarzynski's equality: analytical results.

    PubMed

    Minh, David D L; Adib, Artur B

    2009-02-01

    We apply path integrals to study nonequilibrium work theorems in the context of Brownian dynamics, deriving in particular the equations of motion governing the most typical and most dominant trajectories. For the analytically soluble cases of a moving harmonic potential and a harmonic oscillator with a time-dependent natural frequency, we find such trajectories, evaluate the work-weighted propagators, and validate Jarzynski's equality.

  17. Application of Multidimensional Spectrum Analysis for Analytical Chemistry

    SciTech Connect

    Hatsukawa, Yuichi; Hayakawa, Takehito; Toh, Yosuke; Shinohara, Nobuo; Oshima, Masumi

    1999-12-31

    Feasibility of application of the multidimensional {gamma} ray spectroscopy for analytical chemistry was examined. Two reference igneous rock (JP-1, JB-1a) samples issued by the Geological Survey of Japan (GSJ) were irradiated at a research reactor with thermal neutrons, and {gamma} rays from the radioisotopes produced by neutron capture reactions were measured using a {gamma}-ray detector array. Simultaneously 27 elements were observed with no chemical separation.

  18. Application of multidimensional spectrum analysis for analytical chemistry

    SciTech Connect

    Hatsukawa, Yuichi; Hayakawa, Takehito; Toh, Yosuke; Shinohara, Nobuo; Oshima, Masumi

    1999-11-16

    Feasibility of application of the multidimensional {gamma} ray spectroscopy for analytical chemistry was examined. Two reference igneous rock (JP-1, JB-1a) samples issued by the Geological Survey of Japan (GSJ) were irradiated at a research reactor with thermal neutrons, and {gamma} rays from the radioisotopes produced by neutron capture reactions were measured using a {gamma}-ray detector array. Simultaneously 27 elements were observed with no chemical separation.

  19. Imaging the Crustal and Subducted Slab Structure Beneath Puerto Rico Using Receiver Function Analysis

    NASA Astrophysics Data System (ADS)

    Vanacore, E. A.; Lopez, A. M.; Huerfano Moreno, V. A.

    2015-12-01

    The determination of earthquake locations are dependent on the velocity model selected. Consequently, the refinement and updating of the velocity models used at the local and regional network level is a critical component for network efficiency through location accuracy. With the expansion of broadband instruments within the Puerto Rico -Virgin Islands region, updating the velocity model is a current long term goal of the Puerto Rico Seismic Network (PRSN). As a first step to this long term goal, receiver functions of ~20 broadband stations with data between 2010 and 2015 were calculated using iterative time domain deconvolution. The receiver function analysis not only provides insight into the crustal velocity structure but also leads to a better understanding of the region's larger tectonic structure. Preliminary results of the receiver function analysis exhibit evidence of a "slab signal"; the receiver function backazimuth sweeps for some stations particularly on the northern side of the island contain a strong P to S conversion at approximately 7 seconds which likely corresponds to the top of the slab beneath Puerto Rico. This strong slab signal implies that simple 1-D analyses of the data (e.g. H-K stacking) may lead to misleading results. To further understand the crustal structure of PRVI, we employ a 3D common-conversion-point analysis. This analysis yields a Moho beneath the island between 32-42km and a possible southward dipping slab structure between 60-80km depth. Further analysis is needed to determine the 2D or 3D velocity structure of Puerto Rico and the surrounding environs such as waveform modeling. Given the current geometry of the available array, detailed imaging of the slab and mantle wedge beneath Puerto Rico is limited. PRSN is currently seeking to install denser temporary networks to improve local imaging that will help understand the nature of the crust, mantle wedge and slab structure beneath the island as well as the structure's influence

  20. Preliminary Analysis of the CASES GPS Receiver Performance during Simulated Seismic Displacements

    NASA Astrophysics Data System (ADS)

    De la Rosa-Perkins, A.; Reynolds, A.; Crowley, G.; Azeem, I.

    2014-12-01

    We explore the ability of a new GPS software receiver, called CASES (Connected Autonomous Space Environment Sensor), to measure seismic displacements in realtime. Improvements in GPS technology over the last 20 years allow for precise measurement of ground motion during seismic events. For example, GPS data has been used to calculate displacement histories at an earthquake's epicenter and fault slip estimations with great accuracy. This is supported by the ability to measure displacements directly using GPS, bypassing the double integration that accelerometers require, and by higher clipping limits than seismometers. The CASES receiver developed by ASTRA in collaboration with Cornell University and the University of Texas, Austin represents a new geodetic-quality software-based GPS receiver that measures ionospheric space weather in addition to the usual navigation solution. To demonstrate, in a controlled environment, the ability of the CASES receiver to measure seismic displacements, we simulated ground motions similar to those generated during earthquakes, using a shake box instrumented with an accelerometer and a GPS antenna. The accelerometer measured the box's actual displacement. The box moved on a manually controlled axis that underwent varied one-dimensional motions (from mm to cm) at different frequencies and amplitudes. The CASES receiver was configured to optimize the accuracy of the position solution. We quantified the CASES GPS receiver performance by comparing the GPS solutions against the accelerometer data using various statistical analysis methods. The results of these tests will be presented. The CASES receiver is designed with multiple methods of accessing the data in realtime, ranging from internet connection, blue-tooth, cell-phone modem and Iridium modem. Because the CASES receiver measures ionospheric space weather in addition to the usual navigation solution, CASES provides not only the seimic signal, but also the ionospheric space weather

  1. Marketing Mix Formulation for Higher Education: An Integrated Analysis Employing Analytic Hierarchy Process, Cluster Analysis and Correspondence Analysis

    ERIC Educational Resources Information Center

    Ho, Hsuan-Fu; Hung, Chia-Chi

    2008-01-01

    Purpose: The purpose of this paper is to examine how a graduate institute at National Chiayi University (NCYU), by using a model that integrates analytic hierarchy process, cluster analysis and correspondence analysis, can develop effective marketing strategies. Design/methodology/approach: This is primarily a quantitative study aimed at…

  2. Analytical method for thermal stress analysis of plasma facing materials

    NASA Astrophysics Data System (ADS)

    You, J. H.; Bolt, H.

    2001-10-01

    The thermo-mechanical response of plasma facing materials (PFMs) to heat loads from the fusion plasma is one of the crucial issues in fusion technology. In this work, a fully analytical description of the thermal stress distribution in armour tiles of plasma facing components is presented which is expected to occur under typical high heat flux (HHF) loads. The method of stress superposition is applied considering the temperature gradient and thermal expansion mismatch. Several combinations of PFMs and heat sink metals are analysed and compared. In the framework of the present theoretical model, plastic flow and the effect of residual stress can be quantitatively assessed. Possible failure features are discussed.

  3. Risk analysis of 222Rn gas received from East Anatolian Fault Zone in Turkey

    NASA Astrophysics Data System (ADS)

    Yilmaz, Mucahit; Kulahci, Fatih

    2016-06-01

    In this study, risk analysis and probability distribution methodologies are applied for 222Rn gas data received from Sürgü (Malatya) station located on East Anatolian Fault Zone (EAFZ). 222Rn data are recorded between 21.02.2007 and 06.06.2010 dates. For study are used total 1151 222Rn data. Changes in concentration of 222Rn are modeled as statistically.

  4. Two-port network analysis and modeling of a balanced armature receiver.

    PubMed

    Kim, Noori; Allen, Jont B

    2013-07-01

    Models for acoustic transducers, such as loudspeakers, mastoid bone-drivers, hearing-aid receivers, etc., are critical elements in many acoustic applications. Acoustic transducers employ two-port models to convert between acoustic and electromagnetic signals. This study analyzes a widely-used commercial hearing-aid receiver ED series, manufactured by Knowles Electronics, Inc. Electromagnetic transducer modeling must consider two key elements: a semi-inductor and a gyrator. The semi-inductor accounts for electromagnetic eddy-currents, the 'skin effect' of a conductor (Vanderkooy, 1989), while the gyrator (McMillan, 1946; Tellegen, 1948) accounts for the anti-reciprocity characteristic [Lenz's law (Hunt, 1954, p. 113)]. Aside from Hunt (1954), no publications we know of have included the gyrator element in their electromagnetic transducer models. The most prevalent method of transducer modeling evokes the mobility method, an ideal transformer instead of a gyrator followed by the dual of the mechanical circuit (Beranek, 1954). The mobility approach greatly complicates the analysis. The present study proposes a novel, simplified and rigorous receiver model. Hunt's two-port parameters, the electrical impedance Ze(s), acoustic impedance Za(s) and electro-acoustic transduction coefficient Ta(s), are calculated using ABCD and impedance matrix methods (Van Valkenburg, 1964). The results from electrical input impedance measurements Zin(s), which vary with given acoustical loads, are used in the calculation (Weece and Allen, 2010). The hearing-aid receiver transducer model is designed based on energy transformation flow [electric→ mechanic→ acoustic]. The model has been verified with electrical input impedance, diaphragm velocity in vacuo, and output pressure measurements. This receiver model is suitable for designing most electromagnetic transducers and it can ultimately improve the design of hearing-aid devices by providing a simplified yet accurate, physically

  5. SplitRFLab: A MATLAB GUI toolbox for receiver function analysis based on SplitLab

    NASA Astrophysics Data System (ADS)

    Xu, Mijian; Huang, Hui; Huang, Zhouchuan; Wang, Liangshu

    2016-02-01

    We add new modules for receiver function (RF) analysis in SplitLab toolbox, which includes the manual RF analysis module, automatic RF analysis and related quality control modules, and H- k stacking module. The updated toolbox (named SplitRFLab toolbox), especially its automatic RF analysis module, could calculate the RFs quickly and efficiently, which is very useful in RF analysis with huge amount of seismic data. China is now conducting the ChinArray project that plans to deploy thousands of portable stations across Chinese mainland. Our SplitRFLab toolbox may obtain reliable RF results quickly at the first time, which provide essentially new constraint to the crustal and mantle structures.

  6. Organic analysis and analytical methods development: FY 1995 progress report

    SciTech Connect

    Clauss, S.A.; Hoopes, V.; Rau, J.

    1995-09-01

    This report describes the status of organic analyses and developing analytical methods to account for the organic components in Hanford waste tanks, with particular emphasis on tanks assigned to the Flammable Gas Watch List. The methods that have been developed are illustrated by their application to samples obtained from Tank 241-SY-103 (Tank 103-SY). The analytical data are to serve as an example of the status of methods development and application. Samples of the convective and nonconvective layers from Tank 103-SY were analyzed for total organic carbon (TOC). The TOC value obtained for the nonconvective layer using the hot persulfate method was 10,500 {mu}g C/g. The TOC value obtained from samples of Tank 101-SY was 11,000 {mu}g C/g. The average value for the TOC of the convective layer was 6400 {mu}g C/g. Chelator and chelator fragments in Tank 103-SY samples were identified using derivatization. gas chromatography/mass spectrometry (GC/MS). Organic components were quantified using GC/flame ionization detection. Major components in both the convective and nonconvective-layer samples include ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), succinic acid, nitrosoiminodiacetic acid (NIDA), citric acid, and ethylenediaminetriacetic acid (ED3A). Preliminary results also indicate the presence of C16 and C18 carboxylic acids in the nonconvective-layer sample. Oxalic acid was one of the major components in the nonconvective layer as determined by derivatization GC/flame ionization detection.

  7. Receiver design, performance analysis, and evaluation for space-borne laser altimeters and space-to-space laser ranging systems

    NASA Technical Reports Server (NTRS)

    Davidson, Frederic M.; Sun, Xiaoli; Field, Christopher T.

    1994-01-01

    Accomplishments in the following areas of research are presented: receiver performance study of spaceborne laser altimeters and cloud and aerosol lidars; receiver performance analysis for space-to-space laser ranging systems; and receiver performance study for the Mars Environmental Survey (MESUR).

  8. ICRPG WORKING GROUP ON ANALYTICAL CHEMISTRY ROUND ROBIN NO. 22 -- EUDIOMETRIC ANALYSIS OF POWDERED ALUMINUM,

    DTIC Science & Technology

    Analytical Chemistry voted to conduct a round robin to estimate the interlaboratory reproducibility. The round robin was designed to facilitate statistical analysis of the data. Three samples representing different purity levels as

  9. Receiver design, performance analysis, and evaluation for space-borne laser altimeters and space-to-space laser ranging systems

    NASA Technical Reports Server (NTRS)

    Davidson, Frederic M.; Field, Christopher T.; Sun, Xiaoli

    1996-01-01

    We report here the design and the performance measurements of the breadboard receiver of the Geoscience Laser Altimeter System (GLAS). The measured ranging accuracy was better than 2 cm and 10 cm for 5 ns and 30 ns wide received laser pulses under the expected received signal level, which agreed well with the theoretical analysis. The measured receiver sensitivity or the link margin was also consistent with the theory. The effects of the waveform digitizer sample rate and resolution were also measured.

  10. [Analysis and experimental verification of sensitivity and SNR of laser warning receiver].

    PubMed

    Zhang, Ji-Long; Wang, Ming; Tian, Er-Ming; Li, Xiao; Wang, Zhi-Bin; Zhang, Yue

    2009-01-01

    In order to countermeasure increasingly serious threat from hostile laser in modern war, it is urgent to do research on laser warning technology and system, and the sensitivity and signal to noise ratio (SNR) are two important performance parameters in laser warning system. In the present paper, based on the signal statistical detection theory, a method for calculation of the sensitivity and SNR in coherent detection laser warning receiver (LWR) has been proposed. Firstly, the probabilities of the laser signal and receiver noise were analyzed. Secondly, based on the threshold detection theory and Neyman-Pearson criteria, the signal current equation was established by introducing detection probability factor and false alarm rate factor, then, the mathematical expressions of sensitivity and SNR were deduced. Finally, by using method, the sensitivity and SNR of the sinusoidal grating laser warning receiver developed by our group were analyzed, and the theoretic calculation and experimental results indicate that the SNR analysis method is feasible, and can be used in performance analysis of LWR.

  11. Evidence for underthrusting beneath the Queen Charlotte Margin, British Columbia, from teleseismic receiver function analysis

    NASA Astrophysics Data System (ADS)

    Bustin, A. M. M.; Hyndman, R. D.; Kao, H.; Cassidy, J. F.

    2007-12-01

    The Queen Charlotte Fault zone is the transpressive boundary between the North America and Pacific Plates along the northwestern margin of British Columbia. Two models have been suggested for the accommodation of the ~20 mm yr-1 of convergence along the fault boundary: (1) underthrusting; (2) internal crustal deformation. Strong evidence supporting an underthrusting model is provided by a detailed teleseismic receiver function analysis that defines the underthrusting slab. Forward and inverse modelling techniques were applied to receiver function data calculated at two permanent and four temporary seismic stations within the Queen Charlotte Islands. The modelling reveals a ~10 km thick low-velocity zone dipping eastward at 28° interpreted to be underthrusting oceanic crust. The oceanic crust is located beneath a thin (28 km) eastward thickening (10°) continental crust.

  12. Waste Receiving and Processing (WRAP) Facility Final Safety Analysis Report (FSAR)

    SciTech Connect

    TOMASZEWSKI, T.A.

    2000-04-25

    The Waste Receiving and Processing Facility (WRAP), 2336W Building, on the Hanford Site is designed to receive, confirm, repackage, certify, treat, store, and ship contact-handled transuranic and low-level radioactive waste from past and present U.S. Department of Energy activities. The WRAP facility is comprised of three buildings: 2336W, the main processing facility (also referred to generically as WRAP); 2740W, an administrative support building; and 2620W, a maintenance support building. The support buildings are subject to the normal hazards associated with industrial buildings (no radiological materials are handled) and are not part of this analysis except as they are impacted by operations in the processing building, 2336W. WRAP is designed to provide safer, more efficient methods of handling the waste than currently exist on the Hanford Site and contributes to the achievement of as low as reasonably achievable goals for Hanford Site waste management.

  13. The RIP and block-RIP analysis of Nyquist folding receiver for recovering signals

    NASA Astrophysics Data System (ADS)

    Jiang, Kaili; Chen, Sujuan; Tang, Bin

    2016-12-01

    Modern radar and communication systems require the detection and parameter estimation of signal under a broadband radio frequency (RF) environment. The Nyquist folding receiver (NYFR) is an efficient analog-to-information (A2I) architecture. It can use the compressive sensing (CS) techniques to break the limitations of the analog-to-digital converter (ADC). This paper demonstrates the restricted isometry property (RIP) of the NYFR deterministically by applying the Gershgorin circle theory. And, the NYFR suffers a poor RIP for the broadband signal, which will lead the conventional CS algorithms to be invalid. So, we derive the Fourier spectrum of the broadband signal, which covered multiple Nyquist zones and received by the NYFR. Then, the broadband signal can be regarded as the block-sparse signal. And, the block CS algorithms are applied for recovering the signal based on the analysis of the block-RIP. Finally, the simulation experiments demonstrate the validity of the findings.

  14. A Qualitative Analysis of the Perception of Stigma Among Latinos Receiving Antidepressants

    PubMed Central

    Interian, Alejandro; Martinez, Igda E.; Guarnaccia, Peter J.; Vega, William A.; Escobar, Javier I.

    2008-01-01

    Objective This study sought to describe the role of stigma in antidepressant adherence among Latinos. Methods The study utilized data generated from six focus groups of Latino outpatients receiving antidepressants (N=30). By using a grounded theory approach, qualitative analysis focused specifically on the role of stigma in antidepressant treatment, as well as salient Latino values. Results Perceptions of stigma were related to both the diagnosis of depression and use of antidepressant medication. Qualitative analyses showed that antidepressant use was seen as implying more severe illness, weakness or failure to cope with problems, and being under the effects of a drug. Reports of stigma were also related to social consequences. Also, the perceived negative attributes of antidepressant use were at odds with self-perceived cultural values. Conclusions Stigma was a prominent concern among Latinos receiving antidepressants, and stigma often affected adherence. Furthermore, culture is likely to play an important role in the communication of stigma and its associated complications. PMID:18048562

  15. Fatigue-creep lifetime analysis of four advanced central receiver concepts

    NASA Astrophysics Data System (ADS)

    Jones, J.

    1981-01-01

    Four advanced central receiver concepts were analyzed for their fatigue-creep design lifetimes. Using the flux profiles provided by the designers, the thermal hydraulic performance of an individual tube in a receiver panel was ascertained by computer analysis. A linear model of the tube crown strain for the tube on given thermal and structural finite element analyses were performed. The computed stresses and strains were used in evaluation of the creep and fatigue design lifetimes by N-47 and compared to the desired lifetime of 30 years. Three of the four designs met or exceeded the desired lifetime and the fourth met the desired lifetime when the factor of safety incorporated in N-47 was reduced. All four designs were judged adequate for the current level of design effort.

  16. Crustal structure beneath the eastern Nepal Himalayas and southern Tibet from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Neupane, Arjun Sharma

    The Himalayas are the results of continental collision between the Indian plate and the Eurasian plate and serve as a natural site to study the physical causes and process of mountain building. The crustal structure beneath the Himalayas has been subject to numerous geophysical studies and the variation in the velocity structure across the Himalayan region suggests significant differences in the crustal structure between the southern and northern portion in that region. In this research, a P receiver function analysis has been conducted on data collected for 14 years (2000-2014) from 211 different stations in Eastern Nepal and Southern Tibet, to better understand the seismic velocity structure in the region. The stations cover a large area encompassing the south eastern plains of Nepal, Lesser and Greater Himalayas and the Southern Tibetan Plateau and provide an excellent geometry for seismic structure research. Following the rotation of the two horizontal components to the radial and transverse components and the time iterative deconvolution to obtain the receiver functions the H-K stacking method of Zhu and Kanamori(Zhu and Kanamori, 2000) has been used to convert the time domain receiver functions into H-K domain and obtain the values of crustal thickness and the ratio of the P and S wave velocities. The main trend in the receiver function analysis across the Himalaya from our study reflects the deepening of the moho from about 40 km beneath southern Nepal in the foothills of the Himalaya to about 80 km in southern Tibet. A locally steeper moho deep is obtained in the high range of Himalayas.

  17. Dynamic test/analysis correlation using reduced analytical models

    NASA Technical Reports Server (NTRS)

    Mcgowan, Paul E.; Angelucci, A. F.; Javeed, Mehzad

    1992-01-01

    Test/analysis correlation is an important aspect of the verification of analysis models which are used to predict on-orbit response characteristics of large space structures. This paper presents results of a study using reduced analysis models for performing dynamic test/analysis correlation. The reduced test-analysis model (TAM) has the same number and orientation of DOF as the test measurements. Two reduction methods, static (Guyan) reduction and the Improved Reduced System reduction, are applied to the test/analysis correlation of a laboratory truss structure. Simulated test results and modal test data are used to examine the performance of each method. It is shown that selection of DOF to be retained in the TAM is critical when large structural masses are involved. In addition, the use of modal test results may provide difficulties in TAM accuracy even if a large number of DOF are retained in the TAM.

  18. Dynamic test/analysis correlation using reduced analytical models

    NASA Technical Reports Server (NTRS)

    Mcgowan, Paul E.; Angelucci, A. Filippo; Javeed, Mehzad

    1992-01-01

    Test/analysis correlation is an important aspect of the verification of analysis models which are used to predict on-orbit response characteristics of large space structures. This paper presents results of a study using reduced analysis models for performing dynamic test/analysis correlation. The reduced test-analysis model (TAM) has the same number and orientation of DOF as the test measurements. Two reduction methods, static (Guyan) reduction and the Improved Reduced System (IRS) reduction, are applied to the test/analysis correlation of a laboratory truss structure. Simulated test results and modal test data are used to examine the performance of each method. It is shown that selection of DOF to be retained in the TAM is critical when large structural masses are involved. In addition, the use of modal test results may provide difficulties in TAM accuracy even if a large number of DOF are retained in the TAM.

  19. The Crustal Structure Of The Marmara Region Using Receiver Function Analysis

    NASA Astrophysics Data System (ADS)

    Büyükakpınar, Pınar; Gürbüz, Cemil; Zor, Ekrem

    2016-04-01

    The Marmara region is a rapidly deforming area with high seismic activity in the northwestern Turkey. In order to further understand the crustal structure in the region, we present results from receiver function analysis using the permanent stations in the region by applying H-κ stacking algorithm which gives crustal thickness and Vp/Vs ratio beneath a station. 40 land stations between January of 2008 and April of 2012, and 5 cabled Sea Bottom Observatories which were deployed at the end of 2010 by KOERI located between 40.2°- 41.2° N and 26.5°- 30.5° E were included in the analysis. Approximately 250 teleseismic events from a wide range of epicentral distances with magnitudes greater than Mw 5.5 are used to obtain receiver functions. Furthermore, in order to calculate the receiver functions in time domain using iterative deconvolution technique suggested by Ligorria and Ammon (1999). Consequently, the crustal structure of the region has been reasonably defined and compared with the other studies. As a consequence of the receiver function analysis, the Moho depth variation map and Vp/Vs ratio map were plotted. The Moho depth on average is 31 km. There are no sharp changes in the crustal thickness of the Marmara Region except North Marmara Trough because basin structure of the Marmara Sea where crustal thickness reaches up to 26 km in the same region was not observed. Furthermore, we found overall average Vp/Vs ratio of 1.74, for the region but we obtained low Vp/Vs ratios in the stations located near Çınarcık Basin which varies between 1.64 - 1.74 indicating the effect of basin structure in the area and North Marmara where Vp/Vs ratios vary between 1.60 and 1.70 which is related to the sediment structure of the area. We also acquired higher Vp/Vs ratios which are between 1.86 and 1.96 in the Western Marmara Region. This can be due to increasing mafic content in this area. Additionally, an attempt has been made to invert the radial receiver function of the

  20. Analytical and Experimental Vibration Analysis of a Faulty Gear System

    NASA Technical Reports Server (NTRS)

    Choy, F. K.; Braun, M. J.; Polyshchuk, V.; Zakrajsek, J. J.; Townsend, D. P.; Handschuh, R. F.

    1994-01-01

    A comprehensive analytical procedure was developed for predicting faults in gear transmission systems under normal operating conditions. A gear tooth fault model is developed to simulate the effects of pitting and wear on the vibration signal under normal operating conditions. The model uses changes in the gear mesh stiffness to simulate the effects of gear tooth faults. The overall dynamics of the gear transmission system is evaluated by coupling the dynamics of each individual gear-rotor system through gear mesh forces generated between each gear-rotor system and the bearing forces generated between the rotor and the gearbox structure. The predicted results were compared with experimental results obtained from a spiral bevel gear fatigue test rig at NASA Lewis Research Center. The Wigner-Ville distribution (WVD) was used to give a comprehensive comparison of the predicted and experimental results. The WVD method applied to the experimental results were also compared to other fault detection techniques to verify the WVD's ability to detect the pitting damage, and to determine its relative performance. Overall results show good correlation between the experimental vibration data of the damaged test gear and the predicted vibration from the model with simulated gear tooth pitting damage. Results also verified that the WVD method can successfully detect and locate gear tooth wear and pitting damage.

  1. Sensitivity to imputation models and assumptions in receiver operating characteristic analysis with incomplete data.

    PubMed

    Karakaya, Jale; Karabulut, Erdem; Yucel, Recai M

    Modern statistical methods using incomplete data have been increasingly applied in a wide variety of substantive problems. Similarly, receiver operating characteristic (ROC) analysis, a method used in evaluating diagnostic tests or biomarkers in medical research, has also been increasingly popular problem in both its development and application. While missing-data methods have been applied in ROC analysis, the impact of model mis-specification and/or assumptions (e.g. missing at random) underlying the missing data has not been thoroughly studied. In this work, we study the performance of multiple imputation (MI) inference in ROC analysis. Particularly, we investigate parametric and non-parametric techniques for MI inference under common missingness mechanisms. Depending on the coherency of the imputation model with the underlying data generation mechanism, our results show that MI generally leads to well-calibrated inferences under ignorable missingness mechanisms.

  2. Analysis of Multi-Antenna GNSS Receiver Performance under Jamming Attacks.

    PubMed

    Vagle, Niranjana; Broumandan, Ali; Lachapelle, Gérard

    2016-11-17

    Although antenna array-based Global Navigation Satellite System (GNSS) receivers can be used to mitigate both narrowband and wideband electronic interference sources, measurement distortions induced by array processing methods are not suitable for high precision applications. The measurement distortions have an adverse effect on the carrier phase ambiguity resolution, affecting the navigation solution. Depending on the array attitude information availability and calibration parameters, different spatial processing methods can be implemented although they distort carrier phase measurements in some cases. This paper provides a detailed investigation of the effect of different array processing techniques on array-based GNSS receiver measurements and navigation performance. The main novelty of the paper is to provide a thorough analysis of array-based GNSS receivers employing different beamforming techniques from tracking to navigation solution. Two beamforming techniques, namely Power Minimization (PM) and Minimum Power Distortionless Response (MPDR), are being investigated. In the tracking domain, the carrier Doppler, Phase Lock Indicator (PLI), and Carrier-to-Noise Ratio (C/N₀) are analyzed. Pseudorange and carrier phase measurement distortions and carrier phase position performance are also evaluated. Performance analyses results from simulated GNSS signals and field tests are provided.

  3. Analysis of Multi-Antenna GNSS Receiver Performance under Jamming Attacks

    PubMed Central

    Vagle, Niranjana; Broumandan, Ali; Lachapelle, Gérard

    2016-01-01

    Although antenna array-based Global Navigation Satellite System (GNSS) receivers can be used to mitigate both narrowband and wideband electronic interference sources, measurement distortions induced by array processing methods are not suitable for high precision applications. The measurement distortions have an adverse effect on the carrier phase ambiguity resolution, affecting the navigation solution. Depending on the array attitude information availability and calibration parameters, different spatial processing methods can be implemented although they distort carrier phase measurements in some cases. This paper provides a detailed investigation of the effect of different array processing techniques on array-based GNSS receiver measurements and navigation performance. The main novelty of the paper is to provide a thorough analysis of array-based GNSS receivers employing different beamforming techniques from tracking to navigation solution. Two beamforming techniques, namely Power Minimization (PM) and Minimum Power Distortionless Response (MPDR), are being investigated. In the tracking domain, the carrier Doppler, Phase Lock Indicator (PLI), and Carrier-to-Noise Ratio (C/N0) are analyzed. Pseudorange and carrier phase measurement distortions and carrier phase position performance are also evaluated. Performance analyses results from simulated GNSS signals and field tests are provided. PMID:27869672

  4. Design and Analysis of the Aperture Shield Assembly for a Space Solar Receiver

    NASA Technical Reports Server (NTRS)

    Strumpf, Hal J.; Trinh, Tuan; Westelaken, William; Krystkowiak, Christopher; Avanessian, Vahe; Kerslake, Thomas W.

    1997-01-01

    A joint U.S./Russia program has been conducted to design, develop, fabricate, launch, and operate the world's first space solar dynamic power system on the Russian Space Station Mir. The goal of the program was to demonstrate and confirm that solar dynamic power systems are viable for future space applications such as the International Space Station (ISS). The major components of the system include a solar receiver, a closed Brayton cycle power conversion unit, a power conditioning and control unit, a solar concentrator, a radiator, a thermal control system, and a Space Shuttle carrier. Unfortunately, the mission was demanifested from the ISS Phase 1 Space Shuttle Program in 1996. However, NASA Lewis is proposing to use the fabricated flight hardware as part of an all-American flight demonstration on the ISS in 2002. The present paper concerns the design and analysis of the solar receiver aperture shield assembly. The aperture shield assembly comprises the front face of the cylindrical receiver and is located at the focal plane of the solar concentrator. The aperture shield assembly is a critical component that protects the solar receiver structure from highly concentrated solar fluxes during concentrator off-pointing events. A full-size aperture shield assembly was fabricated. This unit was essentially identical to the flight configuration, with the exception of materials substitution. In addition, a thermal shock test aperture shield assembly was fabricated. This test article utilized the flight materials and was used for high-flux testing in the solar simulator test rig at NASA Lewis. This testing is described in a companion paper.

  5. An Improved Time-Frequency Analysis Method in Interference Detection for GNSS Receivers.

    PubMed

    Sun, Kewen; Jin, Tian; Yang, Dongkai

    2015-04-21

    In this paper, an improved joint time-frequency (TF) analysis method based on a reassigned smoothed pseudo Wigner-Ville distribution (RSPWVD) has been proposed in interference detection for Global Navigation Satellite System (GNSS) receivers. In the RSPWVD, the two-dimensional low-pass filtering smoothing function is introduced to eliminate the cross-terms present in the quadratic TF distribution, and at the same time, the reassignment method is adopted to improve the TF concentration properties of the auto-terms of the signal components. This proposed interference detection method is evaluated by experiments on GPS L1 signals in the disturbing scenarios compared to the state-of-the-art interference detection approaches. The analysis results show that the proposed interference detection technique effectively overcomes the cross-terms problem and also preserves good TF localization properties, which has been proven to be effective and valid to enhance the interference detection performance of the GNSS receivers, particularly in the jamming environments.

  6. An Improved Time-Frequency Analysis Method in Interference Detection for GNSS Receivers

    PubMed Central

    Sun, Kewen; Jin, Tian; Yang, Dongkai

    2015-01-01

    In this paper, an improved joint time-frequency (TF) analysis method based on a reassigned smoothed pseudo Wigner–Ville distribution (RSPWVD) has been proposed in interference detection for Global Navigation Satellite System (GNSS) receivers. In the RSPWVD, the two-dimensional low-pass filtering smoothing function is introduced to eliminate the cross-terms present in the quadratic TF distribution, and at the same time, the reassignment method is adopted to improve the TF concentration properties of the auto-terms of the signal components. This proposed interference detection method is evaluated by experiments on GPS L1 signals in the disturbing scenarios compared to the state-of-the-art interference detection approaches. The analysis results show that the proposed interference detection technique effectively overcomes the cross-terms problem and also preserves good TF localization properties, which has been proven to be effective and valid to enhance the interference detection performance of the GNSS receivers, particularly in the jamming environments. PMID:25905704

  7. Meta-analysis as Statistical and Analytical Method of Journal’s Content Scientific Evaluation

    PubMed Central

    Masic, Izet; Begic, Edin

    2015-01-01

    Introduction: A meta-analysis is a statistical and analytical method which combines and synthesizes different independent studies and integrates their results into one common result. Goal: Analysis of the journals “Medical Archives”, “Materia Socio Medica” and “Acta Informatica Medica”, which are located in the most eminent indexed databases of the biomedical milieu. Material and methods: The study has retrospective and descriptive character, and included the period of the calendar year 2014. Study included six editions of all three journals (total of 18 journals). Results: In this period was published a total of 291 articles (in the “Medical Archives” 110, “Materia Socio Medica” 97, and in “Acta Informatica Medica” 84). The largest number of articles was original articles. Small numbers have been published as professional, review articles and case reports. Clinical events were most common in the first two journals, while in the journal “Acta Informatica Medica” belonged to the field of medical informatics, as part of pre-clinical medical disciplines. Articles are usually required period of fifty to fifty nine days for review. Articles were received from four continents, mostly from Europe. The authors are most often from the territory of Bosnia and Herzegovina, then Iran, Kosovo and Macedonia. Conclusion: The number of articles published each year is increasing, with greater participation of authors from different continents and abroad. Clinical medical disciplines are the most common, with the broader spectrum of topics and with a growing number of original articles. Greater support of the wider scientific community is needed for further development of all three of the aforementioned journals. PMID:25870484

  8. Patient perspectives on care received at community acupuncture clinics: a qualitative thematic analysis

    PubMed Central

    2013-01-01

    Background Community acupuncture is a recent innovation in acupuncture service delivery in the U.S. that aims to improve access to care through low-cost treatments in group-based settings. Patients at community acupuncture clinics represent a broader socioeconomic spectrum and receive more frequent treatments compared to acupuncture users nationwide. As a relatively new model of acupuncture in the U.S., little is known about the experiences of patients at community acupuncture clinics and whether quality of care is compromised through this high-volume model. The aim of this study was to assess patients’ perspectives on the care received through community acupuncture clinics. Methods The investigators conducted qualitative, thematic analysis of written comments from an observational, cross-sectional survey of clients of the Working Class Acupuncture clinics in Portland, Oregon. The survey included an open-ended question for respondents to share comments about their experiences with community acupuncture. Comments were received from 265 community acupuncture patients. Results Qualitative analysis of written comments identified two primary themes that elucidate patients’ perspectives on quality of care: 1) aspects of health care delivery unique to community acupuncture, and 2) patient engagement in health care. Patients identified unique aspects of community acupuncture, including structures that facilitate access, processes that make treatments more comfortable and effective and holistic outcomes including physical improvements, enhanced quality of life, and empowerment. The group setting, community-based locations, and low cost were highlighted as aspects of this model that allow patients to access acupuncture. Conclusions Patients’ perspectives on the values and experiences unique to community acupuncture offer insights on the quality of care received in these settings. The group setting, community-based locations, and low cost of this model potentially

  9. Analysis of Analog Photonic Links Employing Multiple-Channel (Arrayed) Receivers

    DTIC Science & Technology

    2008-11-07

    with an optical amplifier to boost the received optical signal level. While analog links utilizing single-channel and balanced receivers have been...utilizing single-channel and balanced receivers have been thoroughly analyzed, arrayed receiver architec- tures have received far less attention. In...output optical modulators and balanced -detection [8, 9] are frequently employed. This technique has been utilized alone to achieve the first multi

  10. Global sensitivity analysis of analytical vibroacoustic transmission models

    NASA Astrophysics Data System (ADS)

    Christen, Jean-Loup; Ichchou, Mohamed; Troclet, Bernard; Bareille, Olivier; Ouisse, Morvan

    2016-04-01

    Noise reduction issues arise in many engineering problems. One typical vibroacoustic problem is the transmission loss (TL) optimisation and control. The TL depends mainly on the mechanical parameters of the considered media. At early stages of the design, such parameters are not well known. Decision making tools are therefore needed to tackle this issue. In this paper, we consider the use of the Fourier Amplitude Sensitivity Test (FAST) for the analysis of the impact of mechanical parameters on features of interest. FAST is implemented with several structural configurations. FAST method is used to estimate the relative influence of the model parameters while assuming some uncertainty or variability on their values. The method offers a way to synthesize the results of a multiparametric analysis with large variability. Results are presented for transmission loss of isotropic, orthotropic and sandwich plates excited by a diffuse field on one side. Qualitative trends found to agree with the physical expectation. Design rules can then be set up for vibroacoustic indicators. The case of a sandwich plate is taken as an example of the use of this method inside an optimisation process and for uncertainty quantification.

  11. Visual Analytics approach for Lightning data analysis and cell nowcasting

    NASA Astrophysics Data System (ADS)

    Peters, Stefan; Meng, Liqiu; Betz, Hans-Dieter

    2013-04-01

    Thunderstorms and their ground effects, such as flash floods, hail, lightning, strong wind and tornadoes, are responsible for most weather damages (Bonelli & Marcacci 2008). Thus to understand, identify, track and predict lightning cells is essential. An important aspect for decision makers is an appropriate visualization of weather analysis results including the representation of dynamic lightning cells. This work focuses on the visual analysis of lightning data and lightning cell nowcasting which aim to detect and understanding spatial-temporal patterns of moving thunderstorms. Lightnings are described by 3D coordinates and the exact occurrence time of lightnings. The three-dimensionally resolved total lightning data used in our experiment are provided by the European lightning detection network LINET (Betz et al. 2009). In all previous works, lightning point data, detected lightning cells and derived cell tracks are visualized in 2D. Lightning cells are either displayed as 2D convex hulls with or without the underlying lightning point data. Due to recent improvements of lightning data detection and accuracy, there is a growing demand on multidimensional and interactive visualization in particular for decision makers. In a first step lightning cells are identified and tracked. Then an interactive graphic user interface (GUI) is developed to investigate the dynamics of the lightning cells: e.g. changes of cell density, location, extension as well as merging and splitting behavior in 3D over time. In particular a space time cube approach is highlighted along with statistical analysis. Furthermore a lightning cell nowcasting is conducted and visualized. The idea thereby is to predict the following cell features for the next 10-60 minutes including location, centre, extension, density, area, volume, lifetime and cell feature probabilities. The main focus will be set to a suitable interactive visualization of the predicted featured within the GUI. The developed visual

  12. A conflict of analysis: analytical chemistry and milk adulteration in Victorian Britain.

    PubMed

    Steere-Williams, Jacob

    2014-08-01

    This article centres on a particularly intense debate within British analytical chemistry in the late nineteenth century, between local public analysts and the government chemists of the Inland Revenue Service. The two groups differed in both practical methodologies and in the interpretation of analytical findings. The most striking debates in this period were related to milk analysis, highlighted especially in Victorian courtrooms. It was in protracted court cases, such as the well known Manchester Milk Case in 1883, that analytical chemistry was performed between local public analysts and the government chemists, who were often both used as expert witnesses. Victorian courtrooms were thus important sites in the context of the uneven professionalisation of chemistry. I use this tension to highlight what Christopher Hamlin has called the defining feature of Victorian public health, namely conflicts of professional jurisdiction, which adds nuance to histories of the struggle of professionalisation and public credibility in analytical chemistry.

  13. [Receiver operating characteristic analysis and the cost--benefit analysis in determination of the optimal cut-off point].

    PubMed

    Vránová, J; Horák, J; Krátká, K; Hendrichová, M; Kovaírková, K

    2009-01-01

    An overview of the use of Receiver Operating Characteristic (ROC) analysis within medicine is provided. A survey of the theory behind the analysis is offered together with a presentation on how to create a ROC curve and how to use Cost--Benefit analysis to determine the optimal cut-off point or threshold. The use of ROC analysis is exemplified in the "Cost--Benefit analysis" section of the paper. In these examples, it can be seen that the determination of the optimal cut-off point is mainly influenced by the prevalence and the severity of the disease, by the risks and adverse events of treatment or the diagnostic testing, by the overall costs of treating true and false positives (TP and FP), and by the risk of deficient or non-treatment of false negative (FN) cases.

  14. Mantle upwelling beneath Madagascar: evidence from receiver function analysis and shear wave splitting

    NASA Astrophysics Data System (ADS)

    Paul, Jonathan D.; Eakin, Caroline M.

    2017-01-01

    Crustal receiver functions have been calculated from 128 events for two three-component broadband seismomenters located on the south coast (FOMA) and in the central High Plateaux (ABPO) of Madagascar. For each station, crustal thickness and V p /V s ratio were estimated from H- κ plots. Self-consistent receiver functions from a smaller back-azimuthal range were then selected, stacked and inverted to determine shear wave velocity structure as a function of depth. These results were corroborated by guided forward modeling and by Monte Carlo error analysis. The crust is found to be thinner (39 ± 0.7 km) beneath the highland center of Madagascar compared to the coast (44 ± 1.6 km), which is the opposite of what would be expected for crustal isostasy, suggesting that present-day long wavelength topography is maintained, at least in part, dynamically. This inference of dynamic support is corroborated by shear wave splitting analyses at the same stations, which produce an overwhelming majority of null results (>96 %), as expected for vertical mantle flow or asthenospheric upwelling beneath the island. These findings suggest a sub-plate origin for dynamic support.

  15. Joint multifractal analysis based on the partition function approach: analytical analysis, numerical simulation and empirical application

    NASA Astrophysics Data System (ADS)

    Xie, Wen-Jie; Jiang, Zhi-Qiang; Gu, Gao-Feng; Xiong, Xiong; Zhou, Wei-Xing

    2015-10-01

    Many complex systems generate multifractal time series which are long-range cross-correlated. Numerous methods have been proposed to characterize the multifractal nature of these long-range cross correlations. However, several important issues about these methods are not well understood and most methods consider only one moment order. We study the joint multifractal analysis based on partition function with two moment orders, which was initially invented to investigate fluid fields, and derive analytically several important properties. We apply the method numerically to binomial measures with multifractal cross correlations and bivariate fractional Brownian motions without multifractal cross correlations. For binomial multifractal measures, the explicit expressions of mass function, singularity strength and multifractal spectrum of the cross correlations are derived, which agree excellently with the numerical results. We also apply the method to stock market indexes and unveil intriguing multifractality in the cross correlations of index volatilities.

  16. Receiver Function Analysis of Crustal and Upper Mantle Layering Across the Western Superior Province

    NASA Astrophysics Data System (ADS)

    Olaleye, Morounkeji

    2011-12-01

    The Superior Province is the Earth's largest Archean craton. Its western portion in Canada represents the nucleus of the North American continent, and has a lineated structure with well-preserved supracrustal rock sequences, mineral resources, and greenstone-granite terranes. Its strong east-west tectonic fabric is most commonly attributed to the formation and widespread accretion of island arcs and accretionary prisms ˜ 2.6 Ga ago (Lucas et al., 1998). The Superior Province is underlain by lithospheric mantle that exhibits strong regional variations in anisotropy and velocity structure (Darbyshire et al., 2007). The stratigraphy, velocity structure and thickness of the crust and upper-mantle beneath the western Superior Province, were examined through the analysis of seismic discontinuities on the radial and transverse components of P-wave receiver functions. Global earthquakes that occurred between 2003 and 2008 and recorded by 13 broadly spaced FedNor/POLARIS and CNSN three-component broadband seismic stations across western Ontario were used to create receiver functions. Receiver functions were calculated using a panel deconvolution approach (using inter-trace regularization constraints) to improve signal-to-noise ratio. Inversion for lithospheric parameters was carried out through a directed Monte-Carlo search method that uses the neighbourhood algorithm of Sambridge (1999). The receiver function data show indications of crustal and mantle layering. Generally, it was observed that in the western Superior Province, seismic stations in the southern portion of the study area (south of ˜ 51° N): LDIO, EPLO, PNPO, TIMO and NANO reveal a uniform crust, but a complicated and layered mantle; whereas stations in the northern portion of the study area (north of ˜ 51° N): KASO, RLKO, SILO, VIMO and PKLO reveal a more uniform mantle layer, but a stratified crust. The only exception is ATKO, which displays dominant crustal layering, but is located south of ˜ 51° N

  17. Receiving Basin for Offsite Fuels and the Resin Regeneration Facility Safety Analysis Report, Executive Summary

    SciTech Connect

    Shedrow, C.B.

    1999-11-29

    The Safety Analysis Report documents the safety authorization basis for the Receiving Basin for Offsite Fuels (RBOF) and the Resin Regeneration Facility (RRF) at the Savannah River Site (SRS). The present mission of the RBOF and RRF is to continue in providing a facility for the safe receipt, storage, handling, and shipping of spent nuclear fuel assemblies from power and research reactors in the United States, fuel from SRS and other Department of Energy (DOE) reactors, and foreign research reactors fuel, in support of the nonproliferation policy. The RBOF and RRF provide the capability to handle, separate, and transfer wastes generated from nuclear fuel element storage. The DOE and Westinghouse Savannah River Company, the prime operating contractor, are committed to managing these activities in such a manner that the health and safety of the offsite general public, the site worker, the facility worker, and the environment are protected.

  18. Receiver Functions Analysis and Regional Tomography at StromboliVolcano (Italy)

    NASA Astrophysics Data System (ADS)

    Musumeci, C.; Barberi, G.; Martinez-Arevalo, C.; Castellano, M.; Patane, D.

    2006-12-01

    This study focuses on constraining the crust and upper mantle discontinuities at Stromboli volcano by considering both receiver function (RF) analysis on teleseismic body waveforms and regional tomography. The RF technique utilizes the waveforms of Ps conversions from velocity discontinuities to model variations in Vs beneath a seismic station (e.g. Ammon et al., 1990). The method is sensitive to velocity discontinuities, but it can only detect the velocity-depth product, and not the absolute velocity. Therefore, we use the regional tomographic results as an independent constraint on absolute velocity. In order to improve the velocity model beneath the volcano we reviewed the most recent classical local earthquake tomographies available for the thyrrenian region. Here we show a new lithospheric seismic tomography performed in the northeastern Sicily and southern Calabria, including the Aeolian Archipelago and Stromboli volcano area. The dataset, consisting of P and S arrival times from a thousand of earthquakes located in the studied area between 1994-2003, was inverted by using the standard tomography SimulPS and the double-difference algorithm of TomoDD (Zhang and Thurber, 2003) for simultaneous computation of hypocenter parameters and Vp and Vs three dimensional distributions. For RF analysis the seismograms from about 100 teleseismic earthquakes (M greater than 6.0), recorded between 2004 and 2006 at 13 broad-band seismic stations deployed by the INGV, have been considered to compute the receiver function by the Multi-Taper Spectral Correlation (MTSC) technique (Park and Levin, 2000). One key advantage of this method is its resistance to noise, which recommends its use in environments such as ocean sea islands with high noise levels in the seismic bands.

  19. Crustal structure beneath the Japanese Islands inferred from receiver function analysis using similar earthquakes

    NASA Astrophysics Data System (ADS)

    Igarashi, Toshihiro

    2016-04-01

    The stress concentration and strain accumulation process due to inter-plate coupling of the subducting plate should have a large effect on inland shallow earthquakes that occur in the overriding plate. Information on the crustal structure and the crustal thickness is important to understanding their process. In this study, I applied receiver function analysis using similar earthquakes to estimate the crustal velocity structures beneath the Japanese Islands. Because similar earthquakes are caused repeatedly at almost the same place, they are useful for extracting information on spatial distribution and temporal changes of seismic velocity structures beneath the seismic stations. I used telemetric seismographic network data covered the Japanese Islands and moderate-sized similar earthquakes which occurred in the southern Hemisphere with epicentral distances between 30 and 90 degrees for about 26 years from October 1989. Data analysis was performed separately before and after the 2011 Tohoku-Oki earthquake. To identify the spatial distribution of crustal structure, I searched for the best-correlated model between an observed receiver function at each station and synthetic ones by using a grid search method. As results, I clarified the spatial distribution of the crustal velocity structures. The spatial patterns of velocities from the ground surface to 5 km deep are corresponding with basement depth models although the velocities are slower than those of tomography models. They indicate thick sediment layers in several plain and basin areas. The crustal velocity perturbations are consistent with existing tomography models. The active volcanoes correspond low-velocity zones from the upper crust to the crust-mantle transition. A comparison of the crustal structure before and after the 2011 Tohoku-Oki earthquake suggests that the northeastern Japan arc changed to lower velocities in some areas. This kind of velocity changes might be due to other effects such as changes of

  20. Error analysis for semi-analytic displacement derivatives with respect to shape and sizing variables

    NASA Technical Reports Server (NTRS)

    Fenyes, Peter A.; Lust, Robert V.

    1989-01-01

    Sensitivity analysis is fundamental to the solution of structural optimization problems. Consequently, much research has focused on the efficient computation of static displacement derivatives. As originally developed, these methods relied on analytical representations for the derivatives of the structural stiffness matrix (K) with respect to the design variables (b sub i). To extend these methods for use with complex finite element formulations and facilitate their implementation into structural optimization programs using the general finite element method analysis codes, the semi-analytic method was developed. In this method the matrix the derivative of K/the derivative b sub i is approximated by finite difference. Although it is well known that the accuracy of the semi-analytic method is dependent on the finite difference parameter, recent work has suggested that more fundamental inaccuracies exist in the method when used for shape optimization. Another study has argued qualitatively that these errors are related to nonuniform errors in the stiffness matrix derivatives. The accuracy of the semi-analytic method is investigated. A general framework was developed for the error analysis and then it is shown analytically that the errors in the method are entirely accounted for by errors in delta K/delta b sub i. Furthermore, it is demonstrated that acceptable accuracy in the derivatives can be obtained through careful selection of the finite difference parameter.

  1. Receiver design, performance analysis, and evaluation for space-borne laser altimeters and space-to-space laser ranging systems

    NASA Technical Reports Server (NTRS)

    Davidson, Frederic M.; Sun, Xiaoli

    1993-01-01

    This interim report consists of four separate reports from our research on the receivers of NASA's Gravity And Magnetic Experiment Satellite (GAMES). The first report is entitled 'Analysis of phase estimation bias of GAMES receiver due to Doppler shift.' The second report is 'Background radiation on GAMES fine ranging detector from the moon, the planets, and the stars.' The third report is 'Background radiation on GAMES receivers from the ocean sun glitter and the direct sun.' The fourth report is 'GAMES receiver performance versus background radiation power on the detectors.'

  2. ENVIRONMENTAL ANALYTICAL CHEMISTRY OF ...

    EPA Pesticide Factsheets

    Within the scope of a number of emerging contaminant issues in environmental analysis, one area that has received a great deal of public interest has been the assessment of the role of pharmaceuticals and personal care products (PPCPs) as stressors and agents of change in ecosystems as well as their role in unplanned human exposure. The relationship between personal actions and the occurrence of PPCPs in the environment is clear-cut and comprehensible to the public. In this overview, we attempt to examine the separations aspect of the analytical approach to the vast array of potential analytes among this class of compounds. We also highlight the relationship between these compounds and endocrine disrupting compounds (EDCs) and between PPCPs and EDCs and the more traditional environmental analytes such as the persistent organic pollutants (POPs). Although the spectrum of chemical behavior extends from hydrophobic to hydrophilic, the current focus has shifted to moderately and highly polar analytes. Thus, emphasis on HPLC and LC/MS has grown and MS/MS has become a detection technique of choice with either electrospray ionization or atmospheric pressure chemical ionization. This contrasts markedly with the bench mark approach of capillary GC, GC/MS and electron ionization in traditional environmental analysis. The expansion of the analyte list has fostered new vigor in the development of environmental analytical chemistry, modernized the range of tools appli

  3. A Visual Analytics Approach to Structured Data Analysis to Enhance Nonproliferation and Arms Control Verification Activities

    SciTech Connect

    Gillen, David S.

    2014-08-07

    Analysis activities for Nonproliferation and Arms Control verification require the use of many types of data. Tabular structured data, such as Excel spreadsheets and relational databases, have traditionally been used for data mining activities, where specific queries are issued against data to look for matching results. The application of visual analytics tools to structured data enables further exploration of datasets to promote discovery of previously unknown results. This paper discusses the application of a specific visual analytics tool to datasets related to the field of Arms Control and Nonproliferation to promote the use of visual analytics more broadly in this domain. Visual analytics focuses on analytical reasoning facilitated by interactive visual interfaces (Wong and Thomas 2004). It promotes exploratory analysis of data, and complements data mining technologies where known patterns can be mined for. Also with a human in the loop, they can bring in domain knowledge and subject matter expertise. Visual analytics has not widely been applied to this domain. In this paper, we will focus on one type of data: structured data, and show the results of applying a specific visual analytics tool to answer questions in the Arms Control and Nonproliferation domain. We chose to use the T.Rex tool, a visual analytics tool developed at PNNL, which uses a variety of visual exploration patterns to discover relationships in structured datasets, including a facet view, graph view, matrix view, and timeline view. The facet view enables discovery of relationships between categorical information, such as countries and locations. The graph tool visualizes node-link relationship patterns, such as the flow of materials being shipped between parties. The matrix visualization shows highly correlated categories of information. The timeline view shows temporal patterns in data. In this paper, we will use T.Rex with two different datasets to demonstrate how interactive exploration of

  4. Stability analysis of magnetized neutron stars - a semi-analytic approach

    NASA Astrophysics Data System (ADS)

    Herbrik, Marlene; Kokkotas, Kostas D.

    2017-04-01

    We implement a semi-analytic approach for stability analysis, addressing the ongoing uncertainty about stability and structure of neutron star magnetic fields. Applying the energy variational principle, a model system is displaced from its equilibrium state. The related energy density variation is set up analytically, whereas its volume integration is carried out numerically. This facilitates the consideration of more realistic neutron star characteristics within the model compared to analytical treatments. At the same time, our method retains the possibility to yield general information about neutron star magnetic field and composition structures that are likely to be stable. In contrast to numerical studies, classes of parametrized systems can be studied at once, finally constraining realistic configurations for interior neutron star magnetic fields. We apply the stability analysis scheme on polytropic and non-barotropic neutron stars with toroidal, poloidal and mixed fields testing their stability in a Newtonian framework. Furthermore, we provide the analytical scheme for dropping the Cowling approximation in an axisymmetric system and investigate its impact. Our results confirm the instability of simple magnetized neutron star models as well as a stabilization tendency in the case of mixed fields and stratification. These findings agree with analytical studies whose spectrum of model systems we extend by lifting former simplifications.

  5. Application of receiver-operator analysis to diagnostic tests of iron deficiency in man.

    PubMed

    Kim, I; Pollitt, E; Leibel, R L; Viteri, F E; Alvarez, E

    1984-09-01

    The objective of the present report is to demonstrate the use of receiver-operator characteristics (ROC) analysis in the selection of diagnostic tests for iron deficiency in a specific population. Conventional ROC curves were prepared with true positive fraction (TPF) and false positive fraction (FPF) determined by the application of different cut-off points for four indicators of iron status. ROC plots were then transformed into normal deviate scales. The advantages of Gaussian transformation of TPF and FPF when underlying decision functions are normally distributed are: the ROC curve is a straight line; and the separation between the two distributions and shape of these distributions can be simply quantitated as intercepts and slopes. In the present study, pretreatment hemoglobin concentration was the most robust diagnostic indicator of iron deficiency as operationally defined by a response of hemoglobin to iron treatment. Free erythrocyte protoporphyrin was a more sensitive and specific predictor than either serum ferritin or transferin saturation when a stringent operational definition of iron deficiency was used. These findings illustrate the utility of ROC analysis in discriminating between diagnostic indicators having different degrees of accuracy.

  6. Mantle wedge anisotropy in Southern Tyrrhenian Subduction Zone (Italy), from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Piana Agostinetti, Nicola; Park, Jeffrey; Lucente, Francesco Pio

    2008-12-01

    We constrain mantle wedge seismic structure in the Southern Tyrrhenian Subduction Zone (Italy) using teleseismic receiver functions (RF) recorded at station CUC of the Mednet seismographic network. Station CUC lies above the northern portion of the Calabrian slab segment, which is recognized from deep seismicity and tomographic imaging as a narrow, laterally high-arched slab fragment, extending from the surface below Calabria down to the transition zone. To better define the descending slab interface and possible shear-coupled flow in the mantle wedge above the slab, we computed receiver functions from the P-coda of 147 teleseismic events to analyze the back-azimuth dependence of Ps converted phases from interfaces beneath CUC. We stack the RF data-set with back azimuth to compute its harmonic expansion, which relates to the effects of interface dip and anisotropy at layer boundaries. The seismic structure constrained through the RF analysis is characterized in its upper part by a sub-horizontal Moho at about 25 km depth, overlying a thin isotropic layer at top of mantle. For the deeper part, back-azimuth variation suggests two alternative models, each with an anisotropic layer between two dipping interfaces near 70- and 90-km depth, with fast- and slow-symmetry axes, respectively, above the Apennines slab. Although independent evidence suggests a north-south strike for the slab beneath CUC, the trend of the inferred anisotropy is 45° clockwise from north, inconsistent with a simple downdip shear-coupled flow model in the supra-slab mantle wedge. However complexities of flow and induced rock fabric in the Tyrrhenian back arc may arise due to several concurring factors such as the arcuate shape of the Apennines slab, its retreating kinematics, or slab edge effects.

  7. THE IMPORTANCE OF PROPER INTENSITY CALIBRATION FOR RAMAN ANALYSIS OF LOW-LEVEL ANALYTES IN WATER

    EPA Science Inventory

    Modern dispersive Raman spectroscopy offers unique advantages for the analysis of low-concentration analytes in aqueous solution. However, we have found that proper intensity calibration is critical for obtaining these benefits. This is true not only for producing spectra with ...

  8. Social Cognitive Predictors of College Students' Academic Performance and Persistence: A Meta-Analytic Path Analysis

    ERIC Educational Resources Information Center

    Brown, Steven D.; Tramayne, Selena; Hoxha, Denada; Telander, Kyle; Fan, Xiaoyan; Lent, Robert W.

    2008-01-01

    This study tested Social Cognitive Career Theory's (SCCT) academic performance model using a two-stage approach that combined meta-analytic and structural equation modeling methodologies. Unbiased correlations obtained from a previously published meta-analysis [Robbins, S. B., Lauver, K., Le, H., Davis, D., & Langley, R. (2004). Do psychosocial…

  9. Social Cognitive Career Theory, Conscientiousness, and Work Performance: A Meta-Analytic Path Analysis

    ERIC Educational Resources Information Center

    Brown, Steven D.; Lent, Robert W.; Telander, Kyle; Tramayne, Selena

    2011-01-01

    We performed a meta-analytic path analysis of an abbreviated version of social cognitive career theory's (SCCT) model of work performance (Lent, Brown, & Hackett, 1994). The model we tested included the central cognitive predictors of performance (ability, self-efficacy, performance goals), with the exception of outcome expectations. Results…

  10. Analytical solutions and moment analysis of chromatographic models for rectangular pulse injections.

    PubMed

    Qamar, Shamsul; Abbasi, Javeria N; Javeed, Shumaila; Shah, Munawar; Khan, Farman U; Seidel-Morgenstern, Andreas

    2013-11-08

    This work focuses on the analysis of two standard liquid chromatographic models, namely the lumped kinetic model and the equilibrium dispersive model. Analytical solutions, obtained by means of Laplace transformation, are derived for rectangular single solute concentration pulses of finite length and breakthrough curves injected under linear conditions. In order to analyze the solute transport behavior by means of the two models, the temporal moments up to fourth order are calculated from the Laplace-transformed solutions. The limiting cases of continuous injection and negligible mass transfer limitations are evaluated. For validation, the analytical solutions are compared with the numerical solutions of models using the discontinuous Galerkin finite element method. Results of different case studies are discussed for linear and nonlinear adsorption isotherms. The discontinuous Galerkin method is employed to obtain moments for both linear and nonlinear models numerically. Analytically and numerically determined concentration profiles and moments were found to be in good agreement.

  11. Numerical analysis of radiation propagation in innovative volumetric receivers based on selective laser melting techniques

    NASA Astrophysics Data System (ADS)

    Alberti, Fabrizio; Santiago, Sergio; Roccabruna, Mattia; Luque, Salvador; Gonzalez-Aguilar, Jose; Crema, Luigi; Romero, Manuel

    2016-05-01

    Volumetric absorbers constitute one of the key elements in order to achieve high thermal conversion efficiencies in concentrating solar power plants. Regardless of the working fluid or thermodynamic cycle employed, design trends towards higher absorber output temperatures are widespread, which lead to the general need of components of high solar absorptance, high conduction within the receiver material, high internal convection, low radiative and convective heat losses and high mechanical durability. In this context, the use of advanced manufacturing techniques, such as selective laser melting, has allowed for the fabrication of intricate geometries that are capable of fulfilling the previous requirements. This paper presents a parametric design and analysis of the optical performance of volumetric absorbers of variable porosity conducted by means of detailed numerical ray tracing simulations. Sections of variable macroscopic porosity along the absorber depth were constructed by the fractal growth of single-cell structures. Measures of performance analyzed include optical reflection losses from the absorber front and rear faces, penetration of radiation inside the absorber volume, and radiation absorption as a function of absorber depth. The effects of engineering design parameters such as absorber length and wall thickness, material reflectance and porosity distribution on the optical performance of absorbers are discussed, and general design guidelines are given.

  12. Receiver Function Analysis of Strong-motion Stations in Kaohsiung-Pingtung area, Taiwan

    NASA Astrophysics Data System (ADS)

    Lin, Che-Min; Wen, Kuo-Liang; Kuo, Chun-Hsiang; Huang, Jyun-Yan

    2016-04-01

    The Kaohsiung City and Pingtung County are located in southern Taiwan and bounded on the west side by several active faults. The shallow velocity structure of thick alluvium basin in this area should be delineated to understand the seismic site effect of strong ground motion. Receiver Function (RF) is a conventional technique for studying the structure of the crust and upper mantle beneath the seismometer. But, the RF analysis of high-frequency acceleration seismograms is also proved to be feasible for estimating shallow structures recently. This study applied the RF technique on the Strong-motion records of almost one-hundred TSMIP stations in Kaohsiung-Pingtung area to estimate the shallow shear-wave velocity structures. The averaged RFs of all stations exhibit the obvious variation because of the different geologies and site conditions. After the forward modeling of RFs based on the Genetic Algorithms (GA) searching, the shallow shear-wave velocity structures beneath all the strong-motion stations in the Kaohsiung-Pingtung area were estimated to delineate the iso-depth contour maps of the main formation interfaces and a preliminary shallow 3D velocity model.

  13. Transmitter and receiver antenna gain analysis for laser radar and communication systems

    NASA Technical Reports Server (NTRS)

    Klein, B. J.; Degnan, J. J.

    1973-01-01

    A comprehensive and fairly self-contained study of centrally obscured optical transmitting and receiving antennas is presented and is intended for use by the laser radar and communication systems designer. The material is presented in a format which allows the rapid and accurate evaluation of antenna gain. The Fresnel approximation to scalar wave theory is reviewed and the antenna analysis proceeds in terms of the power gain. Conventional range equations may then be used to calculate the power budget. The transmitter calculations, resulting in near and far field antenna gain patterns, assumes the antenna is illuminated by a laser operating in the fundamental cavity mode. A simple equation is derived for matching the incident source distribution to a general antenna configuration for maximum on-axis gain. An interpretation of the resultant gain curves allows a number of auxiliary design curves to be drawn which display the losses in antenna gain due to pointing errors and the cone angle of the outgoing beam as a function of antenna size and central obscuration. The use of telescope defocusing as an approach to spreading the beam for target acquisition is compared to some alternate methods.

  14. Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapy

    NASA Technical Reports Server (NTRS)

    Lednicky, John A.; Vilchez, Regis A.; Keitel, Wendy A.; Visnegarwala, Fehmida; White, Zoe S.; Kozinetz, Claudia A.; Lewis, Dorothy E.; Butel, Janet S.

    2003-01-01

    OBJECTIVE: To assess the frequency of shedding of polyomavirus JC virus (JCV) genotypes in urine of HIV-infected patients receiving highly active antiretroviral therapy (HAART). METHODS: Single samples of urine and blood were collected prospectively from 70 adult HIV-infected patients and 68 uninfected volunteers. Inclusion criteria for HIV-infected patients included an HIV RNA viral load < 1000 copies, CD4 cell count of 200-700 x 106 cells/l, and stable HAART regimen. PCR assays and sequence analysis were carried out using JCV-specific primers against different regions of the virus genome. RESULTS: JCV excretion in urine was more common in HIV-positive patients but not significantly different from that of the HIV-negative group [22/70 (31%) versus 13/68 (19%); P = 0.09]. HIV-positive patients lost the age-related pattern of JCV shedding (P = 0.13) displayed by uninfected subjects (P = 0.01). Among HIV-infected patients significant differences in JCV shedding were related to CD4 cell counts (P = 0.03). Sequence analysis of the JCV regulatory region from both HIV-infected patients and uninfected volunteers revealed all to be JCV archetypal strains. JCV genotypes 1 (36%) and 4 (36%) were the most common among HIV-infected patients, whereas type 2 (77%) was the most frequently detected among HIV-uninfected volunteers. CONCLUSION: These results suggest that JCV shedding is enhanced by modest depressions in immune function during HIV infection. JCV shedding occurred in younger HIV-positive persons than in the healthy controls. As the common types of JCV excreted varied among ethnic groups, JCV genotypes associated with progressive multifocal leukoencephalopathy may reflect demographics of those infected patient populations.

  15. Analysis of solar receiver flux distributions for US/Russian solar dynamic system demonstration on the MIR Space Station

    NASA Technical Reports Server (NTRS)

    Kerslake, Thomas W.; Fincannon, James

    1995-01-01

    The United States and Russia have agreed to jointly develop a solar dynamic (SD) system for flight demonstration on the Russian MIR space station starting in late 1997. Two important components of this SD system are the solar concentrator and heat receiver provided by Russia and the U.S., respectively. This paper describes optical analysis of the concentrator and solar flux predictions on target receiver surfaces. The optical analysis is performed using the code CIRCE2. These analyses account for finite sun size with limb darkening, concentrator surface slope and position errors, concentrator petal thermal deformation, gaps between petals, and the shading effect of the receiver support struts. The receiver spatial flux distributions are then combined with concentrator shadowing predictions. Geometric shadowing patterns are traced from the concentrator to the target receiver surfaces. These patterns vary with time depending on the chosen MIR flight attitude and orbital mechanics of the MIR spacecraft. The resulting predictions provide spatial and temporal receiver flux distributions for any specified mission profile. The impact these flux distributions have on receiver design and control of the Brayton engine are discussed.

  16. Analysis of solar receiver flux distributions for US/Russian solar dynamic system demonstration on the MIR Space Station

    NASA Astrophysics Data System (ADS)

    Kerslake, Thomas W.; Fincannon, James

    1995-06-01

    The United States and Russia have agreed to jointly develop a solar dynamic (SD) system for flight demonstration on the Russian MIR space station starting in late 1997. Two important components of this SD system are the solar concentrator and heat receiver provided by Russia and the U.S., respectively. This paper describes optical analysis of the concentrator and solar flux predictions on target receiver surfaces. The optical analysis is performed using the code CIRCE2. These analyses account for finite sun size with limb darkening, concentrator surface slope and position errors, concentrator petal thermal deformation, gaps between petals, and the shading effect of the receiver support struts. The receiver spatial flux distributions are then combined with concentrator shadowing predictions. Geometric shadowing patterns are traced from the concentrator to the target receiver surfaces. These patterns vary with time depending on the chosen MIR flight attitude and orbital mechanics of the MIR spacecraft. The resulting predictions provide spatial and temporal receiver flux distributions for any specified mission profile. The impact these flux distributions have on receiver design and control of the Brayton engine are discussed.

  17. PICASSSO Ps Receiver Function Analysis of the Lithospheric Structure Beneath the Western Mediterranean

    NASA Astrophysics Data System (ADS)

    Thurner, S.; Palomeras, I.; Levander, A.

    2011-12-01

    Rif and Betic Mountains we observe complex crustal structures, possibly resulting from the associated thrust systems in each region. Along a profile across Morocco, we observe thick crust in the north beneath the Rif Mountains and to the south beneath the northern edge of the West African craton. Near the center of this transect, directly beneath the Atlas, we observe a much thinner crust at ~30-35 km. These receiver functions also reveal a clear LAB at variable depths throughout the study area, with up to a ~100% change in LAB depth from the southern region to the northern region. From south to north, we see an abrupt change in LAB depth from the High Atlas (~85-95 km) to the Middle Atlas (~65-70 km). The LAB remains relatively shallow beneath the Rif (~75 km) and thickens to the north beneath the Betic Mountains (~85-95 km) and the Iberian Massif (~100-125 km). These LAB depth estimates agree well with those from the surface wave analysis presented by Palomeras et al. (this session), and both data sets can be used to better constrain the LAB depth.

  18. Crustal thickness variation beneath the Romanian seismic network from Rayleigh wave dispersion and receiver function analysis

    NASA Astrophysics Data System (ADS)

    Tataru, Dragos; Grecu, Bogdan; Zaharia, Bogdan

    2014-05-01

    Variations in crustal thickness in Romania where determined by joint inversion of P wave receiver functions (RFs) and Rayleigh wave group velocity dispersion. We present new models of shear wave velocity structure of the crust beneath Romanian broad band stations. The data set consist in more than 500 teleseismic earthquake with epicentral distance between 30° and 95°, magnitude greater than 6 and a signal-to-noise ratio greater than 3 for the P-wave pulse. Most epicenters are situated along the northern Pacific Rim and arrive with backazimuths (BAZs) between 0° and 135° at the Romanian seismic network. We combine receiver functions with fundamental-mode of the Rayleigh wave group velocities to further constrain the shear-wave velocity structure.To extract the group velocities we applied the Multiple Filter Technique analysis to the vertical components of the earthquakes recordings. This technique allowed us to identify the Rayleigh wave fundamental mode and to compute the dispersion curves of the group velocities at periods between 10 and 150 s allowing us to resolve shear wave velocities to a depth of 100 km. The time-domain iterative deconvolution procedure of Ligorrıa and Ammon (1999) was employed to deconvolve the vertical component of the teleseismic P waveforms from the corresponding horizontal components and obtain radial and transverse receiver functions at each broadband station. The data are inverted using a joint, linearized inversion scheme (Hermann, 2002) which accounts for the relative influence of each set of observations, and allows a trade-off between fitting the observations, constructing a smooth model, and matching a priori constraints. The results show a thin crust for stations located inside the Pannonian basin (28-30 km) and a thicker crust for those in the East European Platform (36-40 km). The stations within the Southern and Central Carpathian Orogen are characterized by crustal depths of ~35 km. For stations located in the Northern

  19. A semi-analytical decomposition analysis of surface plasmon generation and the optimal nanoledge plasmonic device

    PubMed Central

    Zeng, Zheng; Mendis, Madu N.; Waldeck, David H.; Wei, Jianjun

    2016-01-01

    Surface plasmon resonance (SPR) of nanostructured thin metal films (so-called nanoplasmonics) has attracted intense attention due to its versatility for optical sensing and chip-based device integration. Understanding the underlying physics and developing applications of nanoplasmonic devices with desirable optical properties, e.g. intensity of light scattering and high refractive index (RI) sensitivity at the perforated metal film, is crucial for practical uses in physics, biomedical detection, and environmental monitoring. This work presents a semi-analytical model that enables decomposition and quantitative analysis of surface plasmon generation at a new complex nanoledge aperture structure under plane-wave illumination, thus providing insight on how to optimize plasmonic devices for optimal plasmonic generation efficiencies and RI sensitivity. A factor analysis of parameters (geometric, dielectric-RI, and incident wavelength) relevant to surface plasmon generation is quantitatively investigated to predict the surface plasmon polariton (SPP) generation efficiency. In concert with the analytical treatment, a finite-difference time-domain (FDTD) simulation is used to model the optical transmission spectra and RI sensitivity as a function of the nanoledge device’s geometric parameters, and it shows good agreement with the analytical model. Further validation of the analytical approach is provided by fabricating subwavelength nanoledge devices and testing their optical transmission and RI sensitivity. PMID:26977289

  20. Analytical tools for the analysis of β-carotene and its degradation products

    PubMed Central

    Stutz, H.; Bresgen, N.; Eckl, P. M.

    2015-01-01

    Abstract β-Carotene, the precursor of vitamin A, possesses pronounced radical scavenging properties. This has centered the attention on β-carotene dietary supplementation in healthcare as well as in the therapy of degenerative disorders and several cancer types. However, two intervention trials with β-carotene have revealed adverse effects on two proband groups, that is, cigarette smokers and asbestos-exposed workers. Beside other causative reasons, the detrimental effects observed have been related to the oxidation products of β-carotene. Their generation originates in the polyene structure of β-carotene that is beneficial for radical scavenging, but is also prone to oxidation. Depending on the dominant degradation mechanism, bond cleavage might occur either randomly or at defined positions of the conjugated electron system, resulting in a diversity of cleavage products (CPs). Due to their instability and hydrophobicity, the handling of standards and real samples containing β-carotene and related CPs requires preventive measures during specimen preparation, analyte extraction, and final analysis, to avoid artificial degradation and to preserve the initial analyte portfolio. This review critically discusses different preparation strategies of standards and treatment solutions, and also addresses their protection from oxidation. Additionally, in vitro oxidation strategies for the generation of oxidative model compounds are surveyed. Extraction methods are discussed for volatile and non-volatile CPs individually. Gas chromatography (GC), (ultra)high performance liquid chromatography (U)HPLC, and capillary electrochromatography (CEC) are reviewed as analytical tools for final analyte analysis. For identity confirmation of analytes, mass spectrometry (MS) is indispensable, and the appropriate ionization principles are comprehensively discussed. The final sections cover analysis of real samples and aspects of quality assurance, namely matrix effects and method

  1. Analytical tools for the analysis of β-carotene and its degradation products.

    PubMed

    Stutz, H; Bresgen, N; Eckl, P M

    2015-05-01

    β-Carotene, the precursor of vitamin A, possesses pronounced radical scavenging properties. This has centered the attention on β-carotene dietary supplementation in healthcare as well as in the therapy of degenerative disorders and several cancer types. However, two intervention trials with β-carotene have revealed adverse effects on two proband groups, that is, cigarette smokers and asbestos-exposed workers. Beside other causative reasons, the detrimental effects observed have been related to the oxidation products of β-carotene. Their generation originates in the polyene structure of β-carotene that is beneficial for radical scavenging, but is also prone to oxidation. Depending on the dominant degradation mechanism, bond cleavage might occur either randomly or at defined positions of the conjugated electron system, resulting in a diversity of cleavage products (CPs). Due to their instability and hydrophobicity, the handling of standards and real samples containing β-carotene and related CPs requires preventive measures during specimen preparation, analyte extraction, and final analysis, to avoid artificial degradation and to preserve the initial analyte portfolio. This review critically discusses different preparation strategies of standards and treatment solutions, and also addresses their protection from oxidation. Additionally, in vitro oxidation strategies for the generation of oxidative model compounds are surveyed. Extraction methods are discussed for volatile and non-volatile CPs individually. Gas chromatography (GC), (ultra)high performance liquid chromatography (U)HPLC, and capillary electrochromatography (CEC) are reviewed as analytical tools for final analyte analysis. For identity confirmation of analytes, mass spectrometry (MS) is indispensable, and the appropriate ionization principles are comprehensively discussed. The final sections cover analysis of real samples and aspects of quality assurance, namely matrix effects and method validation.

  2. Receiver subsystem analysis report (RADL Item 4-1). 10-MWe Solar Thermal Central-Receiver Pilot Plant: solar-facilities design integration

    SciTech Connect

    Not Available

    1982-04-01

    The results are presented of those thermal hydraulic, structural, and stress analyses required to demonstrate that the Receiver design for the Barstow Solar Pilot Plant will satisfy the general design and performance requirements during the plant's design life. Recommendations resulting from those analyses and supporting test programs are presented regarding operation of the receiver. The analyses are limited to receiver subsystem major structural parts (primary tower, receiver unit core support structure), pressure parts (absorber panels, feedwater, condensate and steam piping/components, flash tank, and steam mainfold) and shielding. (LEW)

  3. CALUTRON RECEIVER

    DOEpatents

    Barnes, S.W.

    1959-06-16

    An improved receiver and receiver mount for calutrons are described. The receiver can be manipulated from outside the tank by a single control to position it with respect to the beam. A door can be operated exteriorly also to prevent undesired portions of the beam from entering the receiver. The receiver has an improved pocket which is more selective in the ions collected. (T.R.H.)

  4. HEAP: Heat Energy Analysis Program, a computer model simulating solar receivers. [solving the heat transfer problem

    NASA Technical Reports Server (NTRS)

    Lansing, F. L.

    1979-01-01

    A computer program which can distinguish between different receiver designs, and predict transient performance under variable solar flux, or ambient temperatures, etc. has a basic structure that fits a general heat transfer problem, but with specific features that are custom-made for solar receivers. The code is written in MBASIC computer language. The methodology followed in solving the heat transfer problem is explained. A program flow chart, an explanation of input and output tables, and an example of the simulation of a cavity-type solar receiver are included.

  5. Comparative analysis of high-frequency dynamic measurement experiment for vibration sensor and GPS receiver

    NASA Astrophysics Data System (ADS)

    Ding, Keliang; Song, Zichao; Zhou, Mingduan; Liu, Miao

    2015-12-01

    Sensor technology applied in dynamic measurement in recent years become the mainly focus subject of attention. In this paper, the high-frequency data collected by two kinds of sensors from vibration sensor and GPS receiver are comparatively analyzed. The integrated scheme of dynamic measurement is proposed based on the high-frequency data for vibration sensor and GPS receiver. The result of experiment is shown that the above sensors with the some same characteristics based on the advantages of the sensors applied in the scheme. Finally, the feasibility and effectiveness of the integrated scheme for the vibration sensor and GPS receiver is verified in the dynamic measurement experiment.

  6. Receiver operating characteristic analysis for the detection of simulated microcalcifications on mammograms using hardcopy images

    NASA Astrophysics Data System (ADS)

    Lai, Chao-Jen; Shaw, Chris C.; Whitman, Gary J.; Yang, Wei T.; Dempsey, Peter J.; Nguyen, Victoria; Ice, Mary F.

    2006-08-01

    The aim of this study was to compare mammography systems based on three different detectors—a conventional screen-film (SF) combination, an a-Si/CsI flat-panel (FP)-based detector, and a charge-coupled device (CCD)-based x-ray phosphor-based detector—for their performance in detecting simulated microcalcifications (MCs). 112-150 µm calcium carbonate grains were used to simulate MCs and were overlapped with a slab phantom of simulated 50% adipose/50% glandular breast tissue-equivalent material referred to as the uniform background. For the tissue structure background, 200-250 µm calcium carbonate grains were used and overlapped with an anthropomorphic breast phantom. All MC phantom images were acquired with and without magnification (1.8X). The hardcopy images were reviewed by five mammographers. A five-point confidence level rating was used to score each detection task. Receiver operating characteristic (ROC) analysis was performed, and the areas under the ROC curves (Azs) were used to compare the performances of the three mammography systems under various conditions. The results showed that, with a uniform background and contact images, the FP-based system performed significantly better than the SF and the CCD-based systems. For magnified images with a uniform background, the SF and the FP-based systems performed equally well and significantly better than the CCD-based system. With tissue structure background and contact images, the SF system performed significantly better than the FP and the CCD-based systems. With magnified images and a tissue structure background, the SF and the CCD-based systems performed equally well and significantly better than the FP-based system. In the detection of MCs in the fibroglandular and the heterogeneously dense regions, no significant differences were found except that the SF system performed significantly better than the CCD-based system in the fibroglandular regions for the contact images.

  7. Transient analysis of a molten salt central receiver (MSCR) in a solar power plant

    NASA Astrophysics Data System (ADS)

    Joshi, A.; Wang, C.; Akinjiola, O.; Lou, X.; Neuschaefer, C.; Quinn, J.

    2016-05-01

    Alstom is developing solar power tower plants utilizing molten salt as the working fluid. In solar power tower, the molten salt central receiver (MSCR) atop of the tower is constructed of banks of tubes arranged in panels creating a heat transfer surface exposed to the solar irradiation from the heliostat field. The molten salt heat transfer fluid (HTF), in this case 60/40%wt NaNO3-KNO3, flows in serpentine flow through the surface collecting sensible heat thus raising the HTF temperature from 290°C to 565°C. The hot molten salt is stored and dispatched to produce superheated steam in a steam generator, which in turn produces electricity in the steam turbine generator. The MSCR based power plant with a thermal energy storage system (TESS) is a fully dispatchable renewable power plant with a number of opportunities for operational and economic optimization. This paper presents operation and controls challenges to the MSCR and the overall power plant, and the use of dynamic model computer simulation based transient analyses applied to molten salt based solar thermal power plant. This study presents the evaluation of the current MSCR design, using a dynamic model, with emphasis on severe events affecting critical process response, such as MS temperature deviations, and recommend MSCR control design improvements based on the results. Cloud events are the scope of the transient analysis presented in this paper. The paper presents results from a comparative study to examine impacts or effects on key process variables related to controls and operation of the MSCR plant.

  8. The intracrustal structure beneath the Owyhee Plateau, Oregon, from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Hou, T.; Chen, C.; James, D. E.; Fouch, M. J.

    2013-12-01

    The Owyhee Plateau straddles southeastern Oregon, southwestern Idaho, and northern Nevada, and is an isolated block of older, and less modified, continental lithosphere relative to bordering geologic terranes. Previous seismic studies have characterized the Owyhee Plateau as having thickened crust with low Poisson's ratio and high intracrustal S-wave velocities, and distinct, albeit thin, mantle lithosphere. Significant tectonomagmatic activity, including extension in the northern Great Basin, and intraplate volcanism is present on the margins of the Plateau, but very little volcanism takes place within the Plateau itself. The volcanism is expressed as two prominent age-progressive volcanic tracks, the Snake River Plains-Yellowstone and the High Lava Plains, both of which appear to have originated from near the Owyhee Plateau at approximately 12 Ma. Recent ambient noise tomography and scattered-wave imaging reveal the presence of irregular high velocity layering in the Owyhee mid-crust, but the extent and properties of this feature, and its role in the tectonic evolution of the Owyhee Plateau, remain elusive. In this study, we perform detailed single station Ps receiver function analysis to better constrain the discontinuity structures within the Owyhee crust. We use teleseismic waveform data recorded at 28 High Lava Plains seismic array and 12 USArray Transportable Array broadband stations from 2006 to 2009. Preliminary results show coherent signals of converted phase at ~20 km depth, indicating the presence of a positive velocity discontinuity, which may mark the upper bound of the high velocity layer imaged in previous studies. We consider and examine possible effects of seismic anisotropy on our results and are also conducting synthetic experiments to further constrain the properties of this feature.

  9. Performance analysis of MRC spatial diversity receiver system for satellite-to-ground downlink optical transmissions

    NASA Astrophysics Data System (ADS)

    Li, Kangning; Ma, Jing; Tan, Liying; Yu, Siyuan; Cao, Yubin

    2016-10-01

    The performances of satellite-to-ground downlink optical communications over Gamma-Gamma distributed turbulence are studied for multiple apertures receiver system. Maximum ratio combining (MRC) technique is considered as a combining scheme to mitigate the atmospheric turbulence under thermal noise limited conditions. Bit-error rate (BER) performances for on-off keying (OOK) modulated direct detection optical communications are analyzed for MRC diversity receptions through an approximation method. To show the net diversity gain of multiple apertures receiver system, BER performances of MRC receiver system are compared with a single monolithic aperture receiver system with the same total aperture area (same average total incident optical power) for satellite-to-ground downlink optical communications. All the numerical results are also verified by Monte-Carlo (MC) simulations.

  10. Parametric Analysis of Cyclic Phase Change and Energy Storage in Solar Heat Receivers

    NASA Technical Reports Server (NTRS)

    Hall, Carsie A., III; Glakpe, Emmanuel K.; Cannon, Joseph N.; Kerslake, Thomas W.

    1997-01-01

    A parametric study on cyclic melting and freezing of an encapsulated phase change material (PCM), integrated into a solar heat receiver, has been performed. The cyclic nature of the present melt/freeze problem is relevant to latent heat thermal energy storage (LHTES) systems used to power solar Brayton engines in microgravity environments. Specifically, a physical and numerical model of the solar heat receiver component of NASA Lewis Research Center's Ground Test Demonstration (GTD) project was developed. Multi-conjugate effects such as the convective fluid flow of a low-Prandtl-number fluid, coupled with thermal conduction in the phase change material, containment tube and working fluid conduit were accounted for in the model. A single-band thermal radiation model was also included to quantify reradiative energy exchange inside the receiver and losses through the aperture. The eutectic LiF-CaF2 was used as the phase change material (PCM) and a mixture of He/Xe was used as the working fluid coolant. A modified version of the computer code HOTTube was used to generate results in the two-phase regime. Results indicate that parametric changes in receiver gas inlet temperature and receiver heat input effects higher sensitivity to changes in receiver gas exit temperatures.

  11. A Performance Analysis of Low-Cost GPS Receivers in Kinematic Applications

    NASA Astrophysics Data System (ADS)

    Alkan, R. M.; Saka, M. H.

    Low-cost OEM GPS receivers with the capability of tracking the carrier phase are now used for many applications in the navigation and tracking arena. These receivers provide flexibility in applying carrier smoothing algorithms to improve the pseudorange positioning accuracy and even perform carrier-phase differential positioning. In this study, the performance of a low-cost single-frequency OEM GPS receiver for high-accuracy kinematic positioning in marine applications is investigated. As a first step, a set of zero baseline tests were carried out to evaluate the performance of the GPS receivers. In the second stage, a kinematic test was conducted at the Halic (Golden Horn), Istanbul. The results show that kinematic positioning with centimetre level accuracy can be achieved by the low-cost OEM GPS receiver in differential mode, suggesting its use in a variety of kinematic applications. The use of such a system could considerably reduce the cost of the GPS receiver and the total project costs of many applications.

  12. Cancer risk in patients receiving renal replacement therapy: A meta-analysis of cohort studies

    PubMed Central

    Shang, Weifeng; Huang, Liu; Li, Li; Li, Xiaojuan; Zeng, Rui; Ge, Shuwang; Xu, Gang

    2016-01-01

    It has been reported that patients receiving renal replacement therapy (RRT), including dialysis and kidney transplantation, tend to have an increased risk of cancer; however, studies on the degree of this risk have remained inconclusive. The present meta-analysis was therefore performed to quantify the cancer risk in patients with RRT. Cohort studies assessing overall cancer risk in RRT patients published before May 29, 2015 were included following systematic searches with of PubMed, EMBASE and the reference lists of the studies retrieved. Random-effects meta-analyses were used to pool standardized incidence rates (SIRs) with 95% confidence intervals (CIs). Heterogeneity tests, sensitivity analyses and publication bias assessment were performed. A total of 18 studies including 22 cohort studies were eventually identified, which comprised a total of 1,528,719 patients. In comparison with the general population, the pooled SIR for patients with dialysis including non-melanoma skin cancer (NMSC), dialysis excluding NMSC, transplantation including NMSC, transplantation excluding NMSC and RRT were 1.40 (95% CI, 1.36–1.45), 1.35 (95% CI, 1.23–1.50), 3.26 (95% CI, 2.29–4.63), 2.08 (95% CI, 1.73–2.50) and 2.01 (95% CI, 1.70–2.38), respectively. The cancer risk was particularly high in subgroups of large sample size trials, female patients, younger patients (age at first dialysis, 0–34 years; age at transplantation, 0–20 years), the first year of RRT and non-Asian transplant patients. A significant association was also found between RRT and the majority of organ-specific cancers. However, neither dialysis nor transplantation was associated with breast, body of uterus, colorectal or prostate cancer. Significant heterogeneity was found regarding the association between RRT and overall cancer as well as the majority of site-specific cancer types. However, this heterogeneity had no substantial influence on the pooled SIR for overall cancer in RRT according to the

  13. Coffee-ring effect-based simultaneous SERS substrate fabrication and analyte enrichment for trace analysis

    NASA Astrophysics Data System (ADS)

    Wang, Weidong; Yin, Yongguang; Tan, Zhiqiang; Liu, Jingfu

    2014-07-01

    Based on the ``coffee-ring effect'', we developed a highly efficient SERS platform which integrates the fabrication of SERS-active substrates and the preconcentration of analytes into one step. The high sensitivity, robustness, reproducibility and simplicity make this platform ideal for on-site analysis of small volume samples at low concentrations in complex matrices.Based on the ``coffee-ring effect'', we developed a highly efficient SERS platform which integrates the fabrication of SERS-active substrates and the preconcentration of analytes into one step. The high sensitivity, robustness, reproducibility and simplicity make this platform ideal for on-site analysis of small volume samples at low concentrations in complex matrices. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr03198a

  14. Text Stream Trend Analysis using Multiscale Visual Analytics with Applications to Social Media Systems

    SciTech Connect

    Steed, Chad A; Beaver, Justin M; BogenII, Paul L.; Drouhard, Margaret MEG G; Pyle, Joshua M

    2015-01-01

    In this paper, we introduce a new visual analytics system, called Matisse, that allows exploration of global trends in textual information streams with specific application to social media platforms. Despite the potential for real-time situational awareness using these services, interactive analysis of such semi-structured textual information is a challenge due to the high-throughput and high-velocity properties. Matisse addresses these challenges through the following contributions: (1) robust stream data management, (2) automated sen- timent/emotion analytics, (3) inferential temporal, geospatial, and term-frequency visualizations, and (4) a flexible drill-down interaction scheme that progresses from macroscale to microscale views. In addition to describing these contributions, our work-in-progress paper concludes with a practical case study focused on the analysis of Twitter 1% sample stream information captured during the week of the Boston Marathon bombings.

  15. Photoacoustic spectrum analysis for microstructure characterization in biological tissue: analytical model.

    PubMed

    Xu, Guan; Fowlkes, J Brian; Tao, Chao; Liu, Xiaojun; Wang, Xueding

    2015-05-01

    Photoacoustic spectrum (PA) analysis (PASA) has been found to have the ability to identify the microstructures in phantoms and biological tissues. PASA adopts the procedures in ultrasound spectrum analysis, although the signal generation mechanisms related to ultrasound backscatter and PA wave generation differ. The purpose of this study was to theoretically validate PASA. The analytical solution to the power spectrum of PA signals generated by identical microspheres following discrete uniform random distribution in space was derived. The simulation and experiment validation of the analytical solution include: (i) the power spectrum profile of a single microsphere with a diameter of 300 μm, and (ii) the PASA parameters of the PA signals generated by randomly distributed microspheres 100, 200, 300, 400 and 500 μm in diameter, at concentrations of 30, 60, 120, 240, 480 per 1.5(3) cm(3) in the observation range 0.5-13 MHz.

  16. Dynamic analysis of a flexible spacecraft with rotating components. Volume 1: Analytical developments

    NASA Technical Reports Server (NTRS)

    Bodley, C. S.; Devers, A. D.; Park, A. C.

    1975-01-01

    Analytical procedures and digital computer code are presented for the dynamic analysis of a flexible spacecraft with rotating components. Topics, considered include: (1) nonlinear response in the time domain, and (2) linear response in the frequency domain. The spacecraft is assumed to consist of an assembly of connected rigid or flexible subassemblies. The total system is not restricted to a topological connection arrangement and may be acting under the influence of passive or active control systems and external environments. The analytics and associated digital code provide the user with the capability to establish spacecraft system nonlinear total response for specified initial conditions, linear perturbation response about a calculated or specified nominal motion, general frequency response and graphical display, and spacecraft system stability analysis.

  17. Analysis of Volatile Compounds by Advanced Analytical Techniques and Multivariate Chemometrics.

    PubMed

    Lubes, Giuseppe; Goodarzi, Mohammad

    2017-03-17

    Smelling is one of the five senses, which plays an important role in our everyday lives. Volatile compounds are, for example, characteristics of food where some of them can be perceivable by humans because of their aroma. They have a great influence on the decision making of consumers when they choose to use a product or not. In the case where a product has an offensive and strong aroma, many consumers might not appreciate it. On the contrary, soft and fresh natural aromas definitely increase the acceptance of a given product. These properties can drastically influence the economy; thus, it has been of great importance to manufacturers that the aroma of their food product is characterized by analytical means to provide a basis for further optimization processes. A lot of research has been devoted to this domain in order to link the quality of, e.g., a food to its aroma. By knowing the aromatic profile of a food, one can understand the nature of a given product leading to developing new products, which are more acceptable by consumers. There are two ways to analyze volatiles: one is to use human senses and/or sensory instruments, and the other is based on advanced analytical techniques. This work focuses on the latter. Although requirements are simple, low-cost technology is an attractive research target in this domain; most of the data are generated with very high-resolution analytical instruments. Such data gathered based on different analytical instruments normally have broad, overlapping sensitivity profiles and require substantial data analysis. In this review, we have addressed not only the question of the application of chemometrics for aroma analysis but also of the use of different analytical instruments in this field, highlighting the research needed for future focus.

  18. Irreversible and reversible reactive chromatography: analytical solutions and moment analysis for rectangular pulse injections.

    PubMed

    Bibi, Sameena; Qamar, Shamsul; Seidel-Morgenstern, Andreas

    2015-03-13

    This work is concerned with the analysis of models for linear reactive chromatography describing irreversible A→B and reversible A↔B reactions. In contrast to previously published results rectangular reactant pulses are injected into initially empty or pre-equilibrated columns assuming both Dirichlet and Danckwerts boundary conditions. The models consist of two partial differential equations, accounting for convection, longitudinal dispersion and first order chemical reactions. Due to the effect of involved mechanisms on solute transport, analytical and numerical solutions of the models could be helpful to understand, design and optimize chromatographic reactors. The Laplace transformation is applied to solve the model equations analytically for linear adsorption isotherms. Statistical temporal moments are derived from solutions in the Laplace domain. Analytical results are compared with numerical predictions generated using a high-resolution finite volume scheme for two sets of boundary conditions. Several case studies are carried out to analyze reactive liquid chromatographic processes for a wide range of mass transfer and reaction kinetics. Good agreements in the results validate the correctness of the analytical solutions and accuracy of the proposed numerical algorithm.

  19. Techno-economic analysis of receiver replacement scenarios in a parabolic trough field

    NASA Astrophysics Data System (ADS)

    Röger, Marc; Lüpfert, Eckhard; Caron, Simon; Dieckmann, Simon

    2016-05-01

    The heat loss of an evacuated parabolic trough receiver of solar thermal power plants ranges typically between values below 150 and 200 W/m at 350°C. Defects, such as glass breakage by wind events and coating degradation, anti-reflection coating degradation or hydrogen accumulation in the annulus, decrease the annual electricity production. This study examines the effect of different receiver performance loss scenarios on the energetic and economic output of a modern 150-MWel-parabolic trough plant with 7.5-hours molten-salt storage, located in Ma'an, Jordan over the whole lifetime by modeling it in an extended version of the software greenius. Compared to the reference scenario, a wind event in year 5 (10, 15) causing glass envelope breakage and consequential degradation of the selective coating of 5.6% of the receivers reduces the electricity output by 5.1% (3.8%, 2.5%), the net present value is reduced by 36.5% (23.1%, 13.1%). The payback time of receiver replacement is only 0.7 years and hence this measure is recommended. The highest negative impact on performance and net present value of a project has the hydrogen accumulation scenario (50% of field affected) in event year 5 (10,15) reducing net electric output by 10.7% (8.1%, 5.4%) and the net present value by 77.0% (48.7%, 27.6%). Replacement of the receivers or even better an inexpensive repair solution is an energetically and economically sensible solution. The option of investing in premium receivers with Xe-capsule during the construction phase is a viable option if the surplus cost for premium receivers is lower than 10 to 20 percent.

  20. Estimation and analysis of GPS receiver differential code biases using KGN in Korean Peninsula

    NASA Astrophysics Data System (ADS)

    Choi, B. K.; Cho, J. H.; Lee, S. J.

    2011-05-01

    The total electron content (TEC) estimation by the Global Positioning System (GPS) can be seriously affected by the differential code biases (DCB), referred to as inter-frequency biases (IFB), of the satellite and receiver so that an accuracy of GPS-TEC value is dependent on the error of DCBs estimation. In this paper, we proposed the singular value decomposition (SVD) method to estimate the DCB of GPS satellites and receivers using the Korean GPS network (KGN) in South Korea. The receiver DCBs of about 49 GPS reference stations in KGN were determined for the accurate estimation of the regional ionospheric TEC. They obtained from the daily solution have large biases ranging from +5 to +27 ns for geomagnetic quiet days. The receiver DCB of SUWN reference station was compared with the estimates of IGS and JPL global ionosphere map (GIM). The results have shown comparatively good agreement at the level within 0.2 ns. After correction of receiver DCBs and knowing the satellite DCBs, the comparison between the behavior of the estimated TEC and that of GIMs was performed for consecutive three days. We showed that there is a good agreement between KASI model and GIMs.

  1. Analysis of two kinds of tree as physical barriers against erythemal UVB radiation received.

    PubMed

    Ysasi, Gonzalo G; Ribera, Luis J C

    2013-01-01

    Differences between global radiation UVER (erythemal ultraviolet solar radiation) received under full sun and diffuse radiation received under the shadow of two types of tree are analyzed to check the importance of these components on human exposure to UV radiation. Blue Line spores dosimeters of VioSpor were used for measurement of erythemal dose of UV radiation (able to produce erythema in human skin.) The response profile of these devices is extremely similar to human skin, thus they are suitable to determine and predict the interactions between UV erythema and human skin. Measurements were obtained in relatively clear days from February to December 2009 between 9:30 and 15:30 h. Three dosimeters were placed on a horizontal surface: one in full sun and the other two under the shadow of each tree. Values of UVER in both cases, in full sun and under the shadow of pine and Sauce, were obtained. In addition, the comparison was made between values of dose received in each case and the exposure limits recommended by the International Commission on Non-Ionizing Radiation Protection (ICNIRP). Finally, average daily irradiance received under the shadow of each tree in comparison with those received in full sun, was also analyzed using two PMA2100 radiometers situated on a horizontal surface.

  2. CALUTRON RECEIVER

    DOEpatents

    Brunk, W.O.

    1959-09-29

    A description is given for an improved calutron receiver having a face plate lying at an angle to the direction of the entering ion beams but having an opening, the plane of which is substantially perpendicular to that of the entering ion beams. By so positioning the opening in the receiver, the effective area through which the desired material may enter the receiver is increased, and at the same time the effective area through which containattng material may enter the receiver is reduced.

  3. Analytical Round Robin for Elastic-Plastic Analysis of Surface Cracked Plates: Phase I Results

    NASA Technical Reports Server (NTRS)

    Wells, D. N.; Allen, P. A.

    2012-01-01

    An analytical round robin for the elastic-plastic analysis of surface cracks in flat plates was conducted with 15 participants. Experimental results from a surface crack tension test in 2219-T8 aluminum plate provided the basis for the inter-laboratory study (ILS). The study proceeded in a blind fashion given that the analysis methodology was not specified to the participants, and key experimental results were withheld. This approach allowed the ILS to serve as a current measure of the state of the art for elastic-plastic fracture mechanics analysis. The analytical results and the associated methodologies were collected for comparison, and sources of variability were studied and isolated. The results of the study revealed that the J-integral analysis methodology using the domain integral method is robust, providing reliable J-integral values without being overly sensitive to modeling details. General modeling choices such as analysis code, model size (mesh density), crack tip meshing, or boundary conditions, were not found to be sources of significant variability. For analyses controlled only by far-field boundary conditions, the greatest source of variability in the J-integral assessment is introduced through the constitutive model. This variability can be substantially reduced by using crack mouth opening displacements to anchor the assessment. Conclusions provide recommendations for analysis standardization.

  4. Preliminary results from receiver function analysis in a seismological network across the Pamir

    NASA Astrophysics Data System (ADS)

    Schneider, Felix M.; Yuan, Xiaohui; Sippl, Christan; Schurr, Bernd; Mechie, James; Minaev, Vlad; Oimahmadov, Ilhomjon; Gadoev, Mustafo; Abdybachaev, Ulan A.

    2010-05-01

    The multi-disciplinary TIen Shan-PAmir GEodynamic (TIPAGE) program aims to investigate the dynamics of the orogeny of the Tien Shan and Pamir mountains, which are situated in south Kyrgyzstan and east Tajikistan in Central Asia. Deformation and uplift accompanied by crustal thickening is mainly induced by the collision between the Indian and Eurasian continental plates. As a local feature this collision provides the world's largest active intra-continental subduction zone. Within the framework of the TIPAGE program we operate a temporary seismic array consisting of 32 broadband and 8 short period seismic stations for a period of two years (from 2008 to 2010) covering an area of 300 x 300 km over the main part of the central Pamir plateau and the Alai-range of the southern Tien Shan. In the first year 24 broadband stations were set up in a 350-km long north-south profile geometry from Osh in southern Kyrgyzstan to Zorkul in south-eastern Tajikistan with approximately 15 km station spacing. We perform a receiver function (RF) analysis of converted P and S waves from teleseismic earthquakes at epicentral distances of 35-95 degrees with a minimum magnitude of 5.5. Therefore we decompose their wavefields by rotating the coordinate systems of the recorded seismograms from a N,E,Z into a SH,SV,P system. RFs are isolated by deconvolution of the P-component from the SH- and SV-component. They provide a robust tool to locate discontinuities in wave velocity like the Moho and thus represent the method of choice to determine crustal thickness. First results show a crustal thickness of 70-80km. Xenolith findings from depths of 100km reported by Hacker et al. (2005) give indication for even higher values. The N-S profile geometry will produce a high resolution RF image to map the gross crustal and lithospheric structure. In addition a 2D network with additional 16 stations will enable an investigation of lateral structure variation. We give an introduction to the project and

  5. Experiments and analysis on the molten-salt direct-contact absorption receiver concept

    SciTech Connect

    Bohn, M S; Wang, K Y

    1986-11-01

    This paper presents results of recent experiments on the Direct Absorption Receiver (DAR) concept using molten salt as the working fluid. The DAR concept may result in a solar central receiver that costs 50% less than the current tube receiver and has significantly lower operational and maintenance costs. These experiments were aimed at determining whether the DAR concept is technically feasible and were carried out at the Advanced Components Test Facility, Atlanta, GA. Results are based on several days of operating with solar flux ranging up to 50 W/cm/sup 2/ and also on a numerical model that is capable of predicting the thermal performance of the DAR salt film. Issues relating to thermal efficiency, absorber-to-salt heat transfer, and salt film stability are addressed.

  6. Analytical testing

    NASA Technical Reports Server (NTRS)

    Flannelly, W. G.; Fabunmi, J. A.; Nagy, E. J.

    1981-01-01

    Analytical methods for combining flight acceleration and strain data with shake test mobility data to predict the effects of structural changes on flight vibrations and strains are presented. This integration of structural dynamic analysis with flight performance is referred to as analytical testing. The objective of this methodology is to analytically estimate the results of flight testing contemplated structural changes with minimum flying and change trials. The category of changes to the aircraft includes mass, stiffness, absorbers, isolators, and active suppressors. Examples of applying the analytical testing methodology using flight test and shake test data measured on an AH-1G helicopter are included. The techniques and procedures for vibration testing and modal analysis are also described.

  7. CALUTRON RECEIVER

    DOEpatents

    York, H.F.

    1959-07-01

    A receiver construction is presented for calutrons having two or more ion sources and an individual receiver unit for each source. Design requirements dictate that the face plate defining the receiver entrance slots be placed at an angle to the approaching beam, which means that ions striking the face plate are likely to be scattcred into the entrance slots of other receivers. According to the present invention, the face plate has a surface provided with parallel ridges so disposed that one side only of each ridge's exposed directly to the ion beam. The scattered ions are directed away from adjacent receivers by the ridges on the lace plate.

  8. Analytical quality of environmental analysis: Recent results and future trends of the IAEA-ILMR's Analytical Quality Control Program

    SciTech Connect

    Ballestra, S.; Vas, D.; Holm, E.; Lopez, J.J.; Parsi, P. )

    1988-01-01

    The Analytical Quality Control Services Program of the IAEA-ILMR covers a wide variety of intercalibration and reference materials. The purpose of the program is to ensure the comparability of the results obtained by the different participants and to enable laboratories engaged in low-level analyses of marine environmental materials to control their analytical performance. Within the past five years, the International Laboratory of Marine Radioactivity in Monaco has organized eight intercomparison exercises, on a world-wide basis, on natural materials of marine origin comprising sea water, sediment, seaweed and fish flesh. Results on artificial (fission and activation products, transuranium elements) and natural radionuclides were compiled and evaluated. Reference concentration values were established for a number of the intercalibration samples allowing them to become certified as reference materials available for general distribution. The results of the fish flesh sample and those of the deep-sea sediment are reviewed. The present status of three on-going intercomparison exercises on post-Chernobyl samples IAEA-306 (Baltic Sea sediment), IAEA-307 (Mediterranean sea-plant Posidonia oceanica) and IAEA-308 (Mediterranean mixed seaweed) is also described. 1 refs., 4 tabs.

  9. Social cognition and the cerebellum: A meta-analytic connectivity analysis.

    PubMed

    Van Overwalle, Frank; D'aes, Tine; Mariën, Peter

    2015-12-01

    This meta-analytic connectivity modeling (MACM) study explores the functional connectivity of the cerebellum with the cerebrum in social cognitive processes. In a recent meta-analysis, Van Overwalle, Baetens, Mariën, and Vandekerckhove (2014) documented that the cerebellum is implicated in social processes of "body" reading (mirroring; e.g., understanding other persons' intentions from observing their movements) and "mind" reading (mentalizing, e.g., inferring other persons' beliefs, intentions or personality traits, reconstructing persons' past, future, or hypothetical events). In a recent functional connectivity study, Buckner et al. (2011) offered a novel parcellation of cerebellar topography that substantially overlaps with the cerebellar meta-analytic findings of Van Overwalle et al. (2014). This overlap suggests that the involvement of the cerebellum in social reasoning depends on its functional connectivity with the cerebrum. To test this hypothesis, we explored the meta-analytic co-activations as indices of functional connectivity between the cerebellum and the cerebrum during social cognition. The MACM results confirm substantial and distinct connectivity with respect to the functions of (a) action understanding ("body" reading) and (b) mentalizing ("mind" reading). The consistent and strong connectivity findings of this analysis suggest that cerebellar activity during social judgments reflects distinct mirroring and mentalizing functionality, and that these cerebellar functions are connected with corresponding functional networks in the cerebrum.

  10. Perturbation and Nonlinear Dynamic Analysis of Acoustic Phonatory Signal in Parkinsonian Patients Receiving Deep Brain Stimulation

    ERIC Educational Resources Information Center

    Lee, Victoria S.; Zhou, Xiao Ping; Rahn, Douglas A., III; Wang, Emily Q.; Jiang, Jack J.

    2008-01-01

    Nineteen PD patients who received deep brain stimulation (DBS), 10 non-surgical (control) PD patients, and 11 non-pathologic age- and gender-matched subjects performed sustained vowel phonations. The following acoustic measures were obtained on the sustained vowel phonations: correlation dimension (D[subscript 2]), percent jitter, percent shimmer,…

  11. Exact analysis of a balanced receiver for differential phase-shift keying signals.

    PubMed

    Ho, Keang-Po

    2007-03-01

    The performance of differential phase-shift keying signals with a balanced receiver is exactly analyzed by using a closed-form expression without approximation. The numerical results are well matched with previous results based on the saddle-point approximation. The error probability is calculated exactly using the well-known Marcum Q function.

  12. Screening for Depressive Disorders Using the Mood and Anxiety Symptoms Questionnaire Anhedonic Depression Scale: A Receiver-Operating Characteristic Analysis

    ERIC Educational Resources Information Center

    Bredemeier, Keith; Spielberg, Jeffery M.; Silton, Rebecca Levin; Berenbaum, Howard; Heller, Wendy; Miller, Gregory A.

    2010-01-01

    The present study examined the utility of the anhedonic depression scale from the Mood and Anxiety Symptoms Questionnaire (MASQ-AD scale) as a way to screen for depressive disorders. Using receiver-operating characteristic analysis, we examined the sensitivity and specificity of the full 22-item MASQ-AD scale, as well as the 8- and 14-item…

  13. Assessing the Classification Accuracy of Early Numeracy Curriculum-Based Measures Using Receiver Operating Characteristic Curve Analysis

    ERIC Educational Resources Information Center

    Laracy, Seth D.; Hojnoski, Robin L.; Dever, Bridget V.

    2016-01-01

    Receiver operating characteristic curve (ROC) analysis was used to investigate the ability of early numeracy curriculum-based measures (EN-CBM) administered in preschool to predict performance below the 25th and 40th percentiles on a quantity discrimination measure in kindergarten. Areas under the curve derived from a sample of 279 students ranged…

  14. Analytical methods of the U.S. Geological Survey's New York District Water-Analysis Laboratory

    USGS Publications Warehouse

    Lawrence, Gregory B.; Lincoln, Tricia A.; Horan-Ross, Debra A.; Olson, Mark L.; Waldron, Laura A.

    1995-01-01

    The New York District of the U.S. Geological Survey (USGS) in Troy, N.Y., operates a water-analysis laboratory for USGS watershed-research projects in the Northeast that require analyses of precipitation and of dilute surface water and soil water for major ions; it also provides analyses of certain chemical constituents in soils and soil gas samples.This report presents the methods for chemical analyses of water samples, soil-water samples, and soil-gas samples collected in wateshed-research projects. The introduction describes the general materials and technicques for each method and explains the USGS quality-assurance program and data-management procedures; it also explains the use of cross reference to the three most commonly used methods manuals for analysis of dilute waters. The body of the report describes the analytical procedures for (1) solution analysis, (2) soil analysis, and (3) soil-gas analysis. The methods are presented in alphabetical order by constituent. The method for each constituent is preceded by (1) reference codes for pertinent sections of the three manuals mentioned above, (2) a list of the method's applications, and (3) a summary of the procedure. The methods section for each constitutent contains the following categories: instrumentation and equipment, sample preservation and storage, reagents and standards, analytical procedures, quality control, maintenance, interferences, safety considerations, and references. Sufficient information is presented for each method to allow the resulting data to be appropriately used in environmental investigations.

  15. Analytical methods of the U.S. Geological Survey's New York District Water-Analysis Laboratory

    USGS Publications Warehouse

    Lawrence, Gregory B.; Lincoln, Tricia A.; Horan-Ross, Debra A.; Olson, Mark L.; Waldron, Laura A.

    1995-01-01

    The New York District of the U.S. Geological Survey (USGS) in Troy, N.Y., operates a water-analysis laboratory for USGS watershed-research projects in the Northeast that require analyses of precipitation and of dilute surface water and soil water for major ions; it also provides analyses of certain chemical constituents in soils and soil gas samples. This report presents the methods for chemical analyses of water samples, soil-water samples, and soil-gas samples collected in wateshed-research projects. The introduction describes the general materials and technicques for eachmethod and explains the USGS quality-assurance program and data-management procedures; it also explains the use of cross reference to the three most commonly used methods manuals for analysis of dilute waters. The body of the report describes the analytical procedures for (1) solution analysis, (2) soil analysis, and (3) soil-gas analysis. The methods are presented in alphabetical order by constituent. The method for each constituent is preceded by (1) reference codes for pertinent sections of the three manuals mentioned above, (2) a list of the method's applications, and (3) a summary of the procedure. The methods section for each constitutent contains the following categories: instrumentation and equipment, sample preservation and storage, reagents and standards, analytical procedures, quality control, maintenance, interferences, safety considerations, and references. Sufficient information is presented for each method to allow the resulting data to be appropriately used in environmental samples.

  16. Comparative analysis of analytical solutions for F2P(x ,t ) in the DGLAP approach

    NASA Astrophysics Data System (ADS)

    Choudhury, D. K.; Borah, Neelakshi N. K.

    2017-01-01

    Coupled Dokshitzer-Gribov-Lipatov-Altarelli-Parisi equations involving singlet quark and gluon distributions are explored by a Taylor expansion at small x as two first-order partial differential equations in two variables: Bjorken x and t (t =l n Q/2Λ2). The system of equations are then solved by Lagrange's method and the method of characteristics. We obtain the proton structure function F2P(x ,t ) by combining the corresponding nonsinglet and singlet structure functions with both methods. Analytical solutions for F2P(x ,t ) thus obtained are compared with the recent data published by the H1 and ZEUS Collaborations as well as with NNPDF3.0 parametrization, and their compatibility is checked. Comparative analysis favors the analytical solution by Lagrange's method; the plausible reasons behind that are also discussed.

  17. Redundancy in neutron activation analysis: A valuable tool in assuring analytical quality

    SciTech Connect

    Greenberg, R.R.

    1996-12-31

    Neutron activation analysis (NAA) has become widely used and is extremely valuable for the certification of standard reference materials (SRMs) at the National Institute of Standards and Technology (NIST). This is due to a number of reasons. First, NAA has essentially no significant sources of error in common with the other analytical techniques used at NIST to measure inorganic concentrations. This is important because most certified elemental concentrations are derived from the data determined by two (and occasionally more) independent analytical techniques. Two or more techniques are used for SRM certification because, although each technique has previously been evaluated and shown to be accurate, unexpected problems can arise, especially when analyzing new matrices. Another reason for the use of NAA for SRM certification is the potential of this technique for accuracy. The SRM measurements with estimated accuracies of 1 to 2% (at essentially 95% confidence intervals) are routinely made at NIST using NAA.

  18. Analytical analysis for impact of polarization aberration of projection lens on lithographic imaging quality

    NASA Astrophysics Data System (ADS)

    Shen, Lina; Li, Sikun; Wang, Xiangzhao; Yan, Guanyong

    2015-03-01

    In high-NA and hyper-NA lithography systems, the polarization aberration of projection lens leads to imaging degradations. Typically, numerical simulations are used to explore the relationship. In this paper, analytical analysis for the impact of polarization aberration of projection lens on the aerial image of alternating phase-shift mask (Alt-PSM) is realized. The analytical expressions of image placement error (IPE) and best focus shift (BFS) caused by polarization aberration are derived from the intensity of aerial image. The derived expressions match simulation results extremely well, and can be used to understand more fully the detrimental impact of polarization aberration on lithographic imaging quality. The linear relationships between IPE and odd items of Pauli-Zernike polarization aberrations, as well as that between BFS and even items of Pauli-Zernike polarization aberrations are established, using linear polarization illumination. The accuracy of the linear relationships is assessed by the least square method.

  19. Online Flowing Colloidosomes for Sequential Multi-Analyte High-Throughput SERS Analysis.

    PubMed

    Phan-Quang, Gia Chuong; Wee, Elizabeth Hui Zi; Yang, Fengling; Lee, Hiang Kwee; Phang, In Yee; Feng, Xiaotong; Alvarez-Puebla, Ramón A; Ling, Xing Yi

    2017-04-11

    3D plasmonic colloidosomes are superior SERS sensors owing to their high sensitivity and excellent tolerance to laser misalignment. Herein, we incorporate plasmonic colloidosomes in a microfluidic channel for online SERS detection. Our method resolves the poor signal reproducibility and inter-sample contamination in the existing online SERS platforms. Our flow system offers rapid and continuous online detection of 20 samples in less than 5 min with excellent signal reproducibility. The isolated colloidosomes prevent cross-sample and channel contamination, allowing accurate quantification of samples over a concentration range of five orders of magnitude. Our system demonstrates high-resolution multiplex detection with fully preserved signal and Raman features of individual analytes in a mixture. High-throughput multi-assay analysis is performed, which highlights that our system is capable of rapid identification and quantification of a sequence of samples containing various analytes and concentrations.

  20. Low-Cost GNSS Receivers for Local Monitoring: Experimental Simulation, and Analysis of Displacements.

    PubMed

    Biagi, Ludovico; Grec, Florin Cătălin; Negretti, Marco

    2016-12-15

    The geodetic monitoring of local displacements and deformations is often needed for civil engineering structures and natural phenomena like, for example, landslides. A local permanent GNSS (Global Navigation Satellite Systems) network can be installed: receiver positions in the interest area are estimated and monitored with respect to reference stations. Usually, GNSS geodetic receivers are adopted and provide results with accuracies at the millimeter level: however, they are very expensive and the initial cost and the risk of damage and loss can discourage this approach. In this paper the accuracy and the reliability of low-cost u-blox GNSS receivers are experimentally investigated for local monitoring. Two experiments are analyzed. In the first, a baseline (65 m long) between one geodetic reference receiver and one u-blox is continuously observed for one week: the data are processed by hourly sessions and the results provide comparisons between two processing packages and a preliminary accuracy assessment. Then, a network composed of one geodetic and two u-blox receivers is set up. One u-blox is installed on a device (slide) that allows to apply controlled displacements. The geodetic and the other u-blox (at about 130 m) act as references. The experiment lasts about two weeks. The data are again processed by hourly sessions. The estimated displacements of the u-blox on the slide are analyzed and compared with the imposed displacements. All of the results are encouraging: in the first experiment the standard deviations of the residuals are smaller than 5 mm both in the horizontal and vertical; in the second, they are slightly worse but still satisfactory (5 mm in the horizontal and 13 mm in vertical) and the imposed displacements are almost correctly identified.

  1. Low-Cost GNSS Receivers for Local Monitoring: Experimental Simulation, and Analysis of Displacements

    PubMed Central

    Biagi, Ludovico; Grec, Florin Cătălin; Negretti, Marco

    2016-01-01

    The geodetic monitoring of local displacements and deformations is often needed for civil engineering structures and natural phenomena like, for example, landslides. A local permanent GNSS (Global Navigation Satellite Systems) network can be installed: receiver positions in the interest area are estimated and monitored with respect to reference stations. Usually, GNSS geodetic receivers are adopted and provide results with accuracies at the millimeter level: however, they are very expensive and the initial cost and the risk of damage and loss can discourage this approach. In this paper the accuracy and the reliability of low-cost u-blox GNSS receivers are experimentally investigated for local monitoring. Two experiments are analyzed. In the first, a baseline (65 m long) between one geodetic reference receiver and one u-blox is continuously observed for one week: the data are processed by hourly sessions and the results provide comparisons between two processing packages and a preliminary accuracy assessment. Then, a network composed of one geodetic and two u-blox receivers is set up. One u-blox is installed on a device (slide) that allows to apply controlled displacements. The geodetic and the other u-blox (at about 130 m) act as references. The experiment lasts about two weeks. The data are again processed by hourly sessions. The estimated displacements of the u-blox on the slide are analyzed and compared with the imposed displacements. All of the results are encouraging: in the first experiment the standard deviations of the residuals are smaller than 5 mm both in the horizontal and vertical; in the second, they are slightly worse but still satisfactory (5 mm in the horizontal and 13 mm in vertical) and the imposed displacements are almost correctly identified. PMID:27983707

  2. Analytical tools for the analysis of fire debris. A review: 2008-2015.

    PubMed

    Martín-Alberca, Carlos; Ortega-Ojeda, Fernando Ernesto; García-Ruiz, Carmen

    2016-07-20

    The analysis of fire debris evidence might offer crucial information to a forensic investigation, when for instance, there is suspicion of the intentional use of ignitable liquids to initiate a fire. Although the evidence analysis in the laboratory is mainly conducted by a handful of well-established methodologies, during the last eight years several authors proposed noteworthy improvements on these methodologies, suggesting new interesting approaches. This review critically outlines the most up-to-date and suitable tools for the analysis and interpretation of fire debris evidence. The survey about analytical tools covers works published in the 2008-2015 period. It includes sources of consensus-classified reference samples, current standard procedures, new proposals for sample extraction and analysis, and the most novel statistical tools. In addition, this review provides relevant knowledge on the distortion effects of the ignitable liquid chemical fingerprints, which have to be considered during interpretation of results.

  3. Space Trajectories Error Analysis (STEAP) Programs. Volume 1: Analytic manual, update

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Manual revisions are presented for the modified and expanded STEAP series. The STEAP 2 is composed of three independent but related programs: NOMAL for the generation of n-body nominal trajectories performing a number of deterministic guidance events; ERRAN for the linear error analysis and generalized covariance analysis along specific targeted trajectories; and SIMUL for testing the mathematical models used in the navigation and guidance process. The analytic manual provides general problem description, formulation, and solution and the detailed analysis of subroutines. The programmers' manual gives descriptions of the overall structure of the programs as well as the computational flow and analysis of the individual subroutines. The user's manual provides information on the input and output quantities of the programs. These are updates to N69-36472 and N69-36473.

  4. Preliminary analysis of fluctuations in the received uplink-beacon-power data obtained from the GOLD experiments

    NASA Technical Reports Server (NTRS)

    Jeganathan, M.; Wilson, K. E.; Lesh, J. R.

    1996-01-01

    Uplink data from recent free-space optical communication experiments carried out between the Table Mountain Facility and the Japanese Engineering Test Satellite are used to study fluctuations caused by beam propagation through the atmosphere. The influence of atmospheric scintillation, beam wander and jitter, and multiple uplink beams on the statistics of power received by the satellite is analyzed and compared to experimental data. Preliminary analysis indicates the received signal obeys an approximate lognormal distribution, as predicted by the weak-turbulence model, but further characterization of other sources of fluctuations is necessary for accurate link predictions.

  5. Preliminary Analysis of Fluctuations in the Received Uplink-Beacon-Power Data Obtained From the GOLD Experiments

    NASA Technical Reports Server (NTRS)

    Jeganathan, M.; Wilson, K. E.; Lesh, J. R.

    1996-01-01

    Uplink data from recent free-space optical communication experiments carried out between the Table Mountain Facility and the Japanese Engineering Test Satellite are used to study fluctuations caused by beam propagation through the atmosphere. The influence of atmospheric scintillation, beam wander and jitter, and multiple uplink beams on the statistics of power received by the satellite is analyzed and compared to experimental data. Preliminary analysis indicates the received signal obeys an approximate lognormal distribution, as predicted by the weak-turbulence model, but further characterization of other sources of fluctuations is necessary for accurate link predictions.

  6. Improvement of analytical capabilities of neutron activation analysis laboratory at the Colombian Geological Survey

    NASA Astrophysics Data System (ADS)

    Parrado, G.; Cañón, Y.; Peña, M.; Sierra, O.; Porras, A.; Alonso, D.; Herrera, D. C.; Orozco, J.

    2016-07-01

    The Neutron Activation Analysis (NAA) laboratory at the Colombian Geological Survey has developed a technique for multi-elemental analysis of soil and plant matrices, based on Instrumental Neutron Activation Analysis (INAA) using the comparator method. In order to evaluate the analytical capabilities of the technique, the laboratory has been participating in inter-comparison tests organized by Wepal (Wageningen Evaluating Programs for Analytical Laboratories). In this work, the experimental procedure and results for the multi-elemental analysis of four soil and four plant samples during participation in the first round on 2015 of Wepal proficiency test are presented. Only elements with radioactive isotopes with medium and long half-lives have been evaluated, 15 elements for soils (As, Ce, Co, Cr, Cs, Fe, K, La, Na, Rb, Sb, Sc, Th, U and Zn) and 7 elements for plants (Br, Co, Cr, Fe, K, Na and Zn). The performance assessment by Wepal based on Z-score distributions showed that most results obtained |Z-scores| ≤ 3.

  7. Wireless Ad-Hoc Networks with Receiver Multipacket Reception: Performance Analysis and Signal Processing

    DTIC Science & Technology

    2007-11-02

    estimation and symbol detection algorithms are developed for long code wide-band CDMA systems , including systems with multirate and multicode...CDMA systems . If the spreading codes have good cross- and auto-correlation properties, the matched filter front- end suppresses multiaccess...selective fading, however, code orthogonality can not be guaranteed, and the conventional RAKE receiver that uses a bank of matched filters may perform

  8. GNSS software receiver sampling noise and clock jitter performance and impact analysis

    NASA Astrophysics Data System (ADS)

    Chen, Jian Yun; Feng, XuZhe; Li, XianBin; Wu, GuangYao

    2015-02-01

    In the design of a multi-frequency multi-constellation GNSS software defined radio receivers is becoming more and more popular due to its simple architecture, flexible configuration and good coherence in multi-frequency signal processing. It plays an important role in navigation signal processing and signal quality monitoring. In particular, GNSS software defined radio receivers driving the sampling clock of analogue-to-digital converter (ADC) by FPGA implies that a more flexible radio transceiver design is possible. According to the concept of software defined radio (SDR), the ideal is to digitize as close to the antenna as possible. Whereas the carrier frequency of GNSS signal is of the frequency of GHz, converting at this frequency is expensive and consumes more power. Band sampling method is a cheaper, more effective alternative. When using band sampling method, it is possible to sample a RF signal at twice the bandwidth of the signal. Unfortunately, as the other side of the coin, the introduction of SDR concept and band sampling method induce negative influence on the performance of the GNSS receivers. ADC's suffer larger sampling clock jitter generated by FPGA; and low sampling frequency introduces more noise to the receiver. Then the influence of sampling noise cannot be neglected. The paper analyzes the sampling noise, presents its influence on the carrier noise ratio, and derives the ranging error by calculating the synchronization error of the delay locked loop. Simulations aiming at each impact factors of sampling-noise-induced ranging error are performed. Simulation and experiment results show that if the target ranging accuracy is at the level of centimeter, the quantization length should be no less than 8 and the sampling clock jitter should not exceed 30ps.

  9. Application of Nomographs for Analysis and Prediction of Receiver Spurious Response EMI

    DTIC Science & Technology

    1985-07-23

    are one group of qr equipment which require extensive evaluation. The RF equipment& used on aircraft are usually integrated by where: Ir - Receive...0_______________ predictions as shown in figure 16, or ccozplex r -ceiver 75 la spurious response predictiooas as showit -n fig ire 17, DO.5 where multiple...equipment *pAM 34AMas 4 5 - SAuna can avoid the r-tceiver spurious response C41 by aelecting a frequency pair from the n~omograph which Figure 22

  10. Solar power satellite rectenna design study: Directional receiving elements and parallel-series combining analysis

    NASA Technical Reports Server (NTRS)

    Gutmann, R. J.; Borrego, J. M.

    1978-01-01

    Rectenna conversion efficiencies (RF to dc) approximating 85 percent were demonstrated on a small scale, clearly indicating the feasibility and potential of efficiency of microwave power to dc. The overall cost estimates of the solar power satellite indicate that the baseline rectenna subsystem will be between 25 to 40 percent of the system cost. The directional receiving elements and element extensions were studied, along with power combining evaluation and evaluation extensions.

  11. Analysis and Simulation of Disadvantaged Receivers for Multiple-Input Multiple-Output Communications Systems

    DTIC Science & Technology

    2010-09-01

    47 Figure 23. Simulated BER performance of a 2x2 MIMO-OFDM system with Alamouti space-time coding and 16 QAM modulation ...Spectral Density xiv PDF Probability Density Function QAM Quadrature Amplitude Modulation QPSK Quadrature Phase-Shift Keying RF Radio...of possible received symbols in a given modulation scheme (i.e., M- QAM ). It is clear that this will significantly reduce computational time

  12. Second law analysis and optimization of a parabolic trough receiver tube for direct steam generation

    NASA Astrophysics Data System (ADS)

    Nolte, H. C.; Bello-Ochende, T.; Meyer, J. P.

    2015-06-01

    Entropy generation in the receiver tube of a parabolic trough solar collector can mainly be attributed to the fluid friction and finite temperature differences. The contribution of each of these components is investigated under different circumstances. Mass flow rates, tube diameters and operating pressures are investigated to obtain good guidelines for receiver tube and plant design. Operating pressures between 3 MPa (saturation temperature of 233.9 °C) and 9 MPa (saturation temperature of 303.3 °C) were investigated. Results show that small diameters can result in excessive fluid friction, especially when the mass flow rates are high. For most cases, tube diameters beyond 20 mm will exclusively be subject to entropy generation due to finite temperature differences, and entropy generation due to fluid friction will be small to negligible. Increasing the concentration ratio will decrease entropy generation, due to a higher heat flux per unit meter. This will ultimately result in shorter receiver tube lengths. From a simulated annealing optimization it was seen that if the diameter is increased, the entropy generation can be lowered, provided that the concentration ratio is kept constant. However, beyond a certain point gains in minimizing the entropy generation become negligible. The optimal operating pressure will generally increase if the mass flow rate is increased. Finally it was seen that higher operating pressures are more advantageous when the entropy generation minimization is considered in conjunction with the work output.

  13. CALUTRON RECEIVERS

    DOEpatents

    Schmidt, F.H.; Stone, K.F.

    1958-09-01

    S>This patent relates to improvements in calutron devices and, more specifically, describes a receiver fer collecting the ion curreot after it is formed into a beam of non-homogeneous isotropic cross-section. The invention embodies a calutron receiver having an ion receiving pocket for separately collecting and retaining ions traveling in a selected portion of the ion beam and anelectrode for intercepting ions traveling in another selected pontion of the ion beam. The electrode is disposed so as to fix the limit of one side of the pontion of the ion beam admitted iato the ion receiving pocket.

  14. Analytical Services Management System

    SciTech Connect

    Church, Shane; Nigbor, Mike; Hillman, Daniel

    2005-03-30

    Analytical Services Management System (ASMS) provides sample management services. Sample management includes sample planning for analytical requests, sample tracking for shipping and receiving by the laboratory, receipt of the analytical data deliverable, processing the deliverable and payment of the laboratory conducting the analyses. ASMS is a web based application that provides the ability to manage these activities at multiple locations for different customers. ASMS provides for the assignment of single to multiple samples for standard chemical and radiochemical analyses. ASMS is a flexible system which allows the users to request analyses by line item code. Line item codes are selected based on the Basic Ordering Agreement (BOA) format for contracting with participating laboratories. ASMS also allows contracting with non-BOA laboratories using a similar line item code contracting format for their services. ASMS allows sample and analysis tracking from sample planning and collection in the field through sample shipment, laboratory sample receipt, laboratory analysis and submittal of the requested analyses, electronic data transfer, and payment of the laboratories for the completed analyses. The software when in operation contains business sensitive material that is used as a principal portion of the Kaiser Analytical Management Services business model. The software version provided is the most recent version, however the copy of the application does not contain business sensitive data from the associated Oracle tables such as contract information or price per line item code.

  15. Analytical methods in sphingolipidomics: Quantitative and profiling approaches in food analysis.

    PubMed

    Canela, Núria; Herrero, Pol; Mariné, Sílvia; Nadal, Pedro; Ras, Maria Rosa; Rodríguez, Miguel Ángel; Arola, Lluís

    2016-01-08

    In recent years, sphingolipidomics has emerged as an interesting omic science that encompasses the study of the full sphingolipidome characterization, content, structure and activity in cells, tissues or organisms. Like other omics, it has the potential to impact biomarker discovery, drug development and systems biology knowledge. Concretely, dietary food sphingolipids have gained considerable importance due to their extensively reported bioactivity. Because of the complexity of this lipid family and their diversity among foods, powerful analytical methodologies are needed for their study. The analytical tools developed in the past have been improved with the enormous advances made in recent years in mass spectrometry (MS) and chromatography, which allow the convenient and sensitive identification and quantitation of sphingolipid classes and form the basis of current sphingolipidomics methodologies. In addition, novel hyphenated nuclear magnetic resonance (NMR) strategies, new ionization strategies, and MS imaging are outlined as promising technologies to shape the future of sphingolipid analyses. This review traces the analytical methods of sphingolipidomics in food analysis concerning sample extraction, chromatographic separation, the identification and quantification of sphingolipids by MS and their structural elucidation by NMR.

  16. Analytical analysis of borehole experiments for the estimation of subsurface thermal properties

    NASA Astrophysics Data System (ADS)

    Moscoso Lembcke, Luis G.; Roubinet, Delphine; Gidel, Floriane; Irving, James; Pehme, Peeter; Parker, Beth L.

    2016-05-01

    Estimating subsurface thermal properties is required in many research fields and applications. To this end, borehole experiments such as the thermal response test (TRT) and active-line-source (ALS) method are of significant interest because they allow us to determine thermal property estimates in situ. With these methods, the subsurface thermal conductivity and diffusivity are typically estimated using asymptotic analytical expressions, whose simplifying assumptions have an impact on the accuracy of the values obtained. In this paper, we develop new analytical tools for interpreting borehole thermal experiments, and we use these tools to assess the impact of such assumptions on thermal property estimates. Quite importantly, our results show that the simplifying assumptions of currently used analytical models can result in errors in the estimated thermal conductivity and diffusivity of up to 60% and 40%, respectively. We also show that these errors are more important for short-term analysis and can be reduced with an appropriate choice of experimental duration. Our results demonstrate the need for cautious interpretation of the data collected during TRT and ALS experiments as well as for improvement of the existing in-situ experimental methods.

  17. Numerical analysis of 50 Gbaud homodyne coherent receivers relying on line-coding and injection locking in lasers

    NASA Astrophysics Data System (ADS)

    Xydas, Yannis; Ressopoulos, Constantinos; Bogris, Adonis

    2015-12-01

    We present a numerical analysis of 50 Gbaud coherent detection enabled by injection locked lasers and line coding. The coherent receiver was tested with respect to an ideal receiver for two higher order modulation formats (16-QAM, QPSK) and under diverse operating regimes relating to the slave laser linewidth properties, the injection level and the frequency detuning between the incoming signal and the slave laser. The impact of the slave laser properties and line coding techniques on the receiver performance is highlighted showing that the technique could be used as a practical solution in order to enable low-cost and short reach n × 100 Gb/s Ethernet communication systems with the potential of flexibility in terms of the data rate.

  18. Analytical modeling of the input admittance of an electric drive for stability analysis purposes

    NASA Astrophysics Data System (ADS)

    Girinon, S.; Baumann, C.; Piquet, H.; Roux, N.

    2009-07-01

    Embedded electric HVDC distribution network are facing difficult issues on quality and stability concerns. In order to help to resolve those problems, this paper proposes to develop an analytical model of an electric drive. This self-contained model includes an inverter, its regulation loops and the PMSM. After comparing the model with its equivalent (abc) full model, the study focuses on frequency analysis. The association with an input filter helps in expressing stability of the whole assembly by means of Routh-Hurtwitz criterion.

  19. An analytical approach to grid sensitivity analysis. [of NACA wing sections

    NASA Technical Reports Server (NTRS)

    Sadrehaghighi, Ideen; Smith, Robert E.; Tiwari, Surendra N.

    1992-01-01

    Sensitivity analysis in Computational Fluid Dynamics with emphasis on grids and surface parameterization is described. An interactive algebraic grid-generation technique is employed to generate C-type grids around NACA four-digit wing sections. An analytical procedure is developed for calculating grid sensitivity with respect to design parameters of a wing section. A comparison of the sensitivity with that obtained using a finite-difference approach is made. Grid sensitivity with respect to grid parameters, such as grid-stretching coefficients, are also investigated. Using the resultant grid sensitivity, aerodynamic sensitivity is obtained using the compressible two-dimensional thin-layer Navier-Stokes equations.

  20. An analytical approach to grid sensitivity analysis for NACA four-digit wing sections

    NASA Technical Reports Server (NTRS)

    Sadrehaghighi, I.; Tiwari, S. N.

    1992-01-01

    Sensitivity analysis in computational fluid dynamics with emphasis on grids and surface parameterization is described. An interactive algebraic grid-generation technique is employed to generate C-type grids around NACA four-digit wing sections. An analytical procedure is developed for calculating grid sensitivity with respect to design parameters of a wing section. A comparison of the sensitivity with that obtained using a finite difference approach is made. Grid sensitivity with respect to grid parameters, such as grid-stretching coefficients, are also investigated. Using the resultant grid sensitivity, aerodynamic sensitivity is obtained using the compressible two-dimensional thin-layer Navier-Stokes equations.

  1. Selection of analytical methods for mixed waste analysis at the Hanford Site

    SciTech Connect

    Morant, P.M.

    1994-09-01

    This document describes the process that the US Department of Energy (DOE), Richland Operations Office (RL) and contractor laboratories use to select appropriate or develop new or modified analytical methods. These methods are needed to provide reliable mixed waste characterization data that meet project-specific quality assurance (QA) requirements while also meeting health and safety standards for handling radioactive materials. This process will provide the technical basis for DOE`s analysis of mixed waste and support requests for regulatory approval of these new methods when they are used to satisfy the regulatory requirements of the Hanford Federal Facility Agreement and Consent Order (Tri-party Agreement) (Ecology et al. 1992).

  2. Algal Biomass Analysis by Laser-Based Analytical Techniques—A Review

    PubMed Central

    Pořízka, Pavel; Prochazková, Petra; Prochazka, David; Sládková, Lucia; Novotný, Jan; Petrilak, Michal; Brada, Michal; Samek, Ota; Pilát, Zdeněk; Zemánek, Pavel; Adam, Vojtěch; Kizek, René; Novotný, Karel; Kaiser, Jozef

    2014-01-01

    Algal biomass that is represented mainly by commercially grown algal strains has recently found many potential applications in various fields of interest. Its utilization has been found advantageous in the fields of bioremediation, biofuel production and the food industry. This paper reviews recent developments in the analysis of algal biomass with the main focus on the Laser-Induced Breakdown Spectroscopy, Raman spectroscopy, and partly Laser-Ablation Inductively Coupled Plasma techniques. The advantages of the selected laser-based analytical techniques are revealed and their fields of use are discussed in detail. PMID:25251409

  3. A Numerical and Analytic Analysis of Nonlinear Implicit Differential Equations Arising in Control and Circuit Problems

    DTIC Science & Technology

    1991-01-15

    This research project was to develop methods for the numerical and analytic analysis of implicit systems of differential equations, (DAE)- F(x’, z ,t...0 (1) which are not equivalent to an explicit ordinary differential equation (ODE), (ODE) z ’ = G( z , t) (2) That is, the Jacobian Fe of (1) is...structure theorems and a general numerical procedure for the linear time varying DAE E(t)w’(t) + F(t) z (t) = f(t) (3) This numerical algorithm was the

  4. Analysis of 10B by PIGE with factor analytical gamma-ray peak identification.

    PubMed

    Savolainen, S; Räisänen, J; Eteläniemi, V; Abo Ramadan, U A; Kallio, M

    1995-09-01

    Studying the biodistribution of boronated compounds for B neutron capture therapy (BNCT) requires the accurate detection of low levels of boron (10B) in biological samples. Proton induced gamma-ray emission analysis (PIGE) of 10B was found to be viable in a study of low density lipoprotein (LDL), in tissue and blood samples. However, the method is sensitive to Na present in the samples and can therefore not be used for accurate measurements of 10B concentrations below 5 ppm in samples containing Na. PIGE can be considered to be an appropriate reference method for chemical B analysis. The factor analytical method presented here is the most objective way to separate Na and B peaks from each other, and the factorizing method can be applied in different forms of spectral analysis.

  5. P- and S-Receiver Function Analysis of Borehole Broadband Ocean Bottom Seismic Data

    NASA Astrophysics Data System (ADS)

    Kumar, P.; Kawakatsu, H.; Shinohara, M.; Kanazawa, T.; Araki, E.; Suyehiro, K.

    2008-12-01

    We use P- (Prf) and S-receiver functions (Srf) techniques to decipher the lithospheric thickness of oceanic plates using the borehole broadband seismological data set. These stations are deployed under Japanese Ocean Hemisphere network Project (OHP): WP1 and WP2 in the Philippine sea and the northwestern Pacific ocean, respectively. Both the stations are located in a borehole of depth ~500m with water column of thickness ~5km that produces P-waves water reverberations. These water reverberations travel almost vertically downward and contaminate the vertical component of seismograms. To minimize the water multiples in case of Prf, we prefer the Radial receiver functions and in case of Srf, we used P-Sv-Sh components. Reflectivity synthetics show that the effect of water reverberations have no effect on Sp phases, as multiples arrive latter than the primary S-phase while the radial components are least affected in case of Prf. We found a consistent negative phase interpreted as Lithosphere-Asthenosphere Boundary (LAB) apart from a positive phase corresponding to Moho in both the receiver functions. For WP1 the LAB is at 71±1.8 km (for 49Ma lithospheric age, Western Philippine Sea plate) and 50±1.4 km (for 20Ma, Eastern Philippine Sea plate); for WP2 in the Pacific ocean the lithospheric thickness is 76±4.2 km (for 129Ma). For the observed Prf, the synthetic studies show that the observed amplitude of negative phases are not sufficient enough to match only with water demanding for the presence of a lvl. The thicknesses of the oceanic plates estimated above is consistent with the thermally controlled origin for the oceanic LAB and since it is a sharp boundary (~3s), indicates chemical or fabric origin (Kawakatsu et al., 2008, this meeting).

  6. Receiver function analysis and preliminary body wave tomography of the MACOMO network in Madagascar

    NASA Astrophysics Data System (ADS)

    Pratt, M. J.; Wysession, M. E.; Wiens, D. A.; Nyblade, A.; Aleqabi, G. I.; Shore, P.; Rambolamana, G.; Sy Tanjona Andriampenomanana ny Ony, F.; Rakotondraibe, T.

    2013-12-01

    We present results from a set of seismological studies of the continental island of Madagascar using new seismic data from the NSF-funded MACOMO (MAdagascar, COmores, and MOzambique) IRIS PASSCAL broadband seismometer array. MACOMO involved the deployment during 2011-2013 of 26 broadband seismometers in Madagascar and 6 seismometers in Mozambique, providing the first seismic imaging across the world's 4th-largest island. We present preliminary crustal structure variations from receiver function analyses and body wave tomography results. We calculate radial receiver functions for all Madagascar stations and use the weighted linear regression methodology of Herrmann and Ammon [2002] to invert for shear velocity. Upper mantle and crustal structures from the receiver function analyses are used to help determine starting models for the teleseismic travel-time tomography. The tectonic structure of Madagascar is generally divided into four crustal blocks. Initial seismic imaging shows that the Archean Antongil block that runs along the east of the island has the thickest crust (>40 km) and three Proterozoic terranes that make up the central highlands and are bounded by fault and shear zones are closer to the average crustal thickness (35 km). There has been late Cenozoic intraplate volcanism in northern and central Madagascar (as recently as 1 million years ago), and different hypotheses for its origin will be evaluated by the preliminary results from the three different seismic studies. Complete analyses will be done incorporating seismic data from simultaneous and complementary array of both land- and ocean-based seismometers from French and German deployments.

  7. Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine.

    PubMed

    Cansu, Ali; Serdaroglu, Ayse; Biberoglu, Gursel; Tumer, Leyla; Hirfanoglu, Tugba Luleci; Ezgu, Fatih Suheyl; Hasanoglu, Alev

    2011-12-01

    This prospective study was designed to investigate whether or not monotherapy with sodium valproate (VPA) or oxcarbazepine (OXC) affects plasma levels of fatty acylcarnitine esters in children with epilepsy. A total of 56 children with idiopathic partial or generalised epilepsy were included in the study. Patients were assigned to receive either VPA or OXC monotherapy. Free carnitine (C0) and acylcarnitine profiles of the patients were investigated using tandem mass spectrometry at baseline and at six and 18 months after commencement of therapy. For patients receiving VPA or OXC monotherapy, there were no significant differences in plasma levels of C0, compared with baseline, at six and 18 months (p>0.05). Treatment with VPA for six and 18 months correlated with a significant increase in 3-hydroxy-isovalerylcarnitine (C5-OH) (six months: +23%; 18 months: +73%), and significant decreases in the following acylcarnitines: C6-acylcarnitine (six months: -60%; 18 months: -66%), C14-acylcarnitine (six months: -25%; 18 months: -38%), C16-acylcarnitine (six months: -73%; 18 months: -73%), and C18:1-OH-acylcarnitine (six months: -60%; 18 months: -70%), compared with baseline (p<0.05). In patients receiving OXC monotherapy, on the other hand, plasma concentrations (μmol/L) of acylcarnitines (from C2 to C18:1-OH) fell within the normal reference range. The results of this study indicate that there are significant biochemical changes in acylcarnitines in ambulatory children on VPA monotherapy but these are not clinically significant. OXC monotherapy had no effect on acylcarnitine metabolism in ambulatory children.

  8. Crustal Thickness Variations Across Eastern Canada and Maine From Receiver Function Analysis

    NASA Astrophysics Data System (ADS)

    Hobbs, T.; Darbyshire, F. A.

    2010-12-01

    In 2007 and 2009, seven new broadband seismograph stations were installed in central and southern Québec, filling an important gap in network coverage across the region. The majority of the stations are situated within the Archean Superior craton, with a further two located in the Proterozoic Grenville Province. In this study, we examine receiver functions calculated from large teleseismic earthquakes recorded at the station array, together with three older stations - one affiliated to the permanent Canadian National Seismograph Network, one to the temporary Canadian POLARIS array, and a final station belonging to the USArray backbone network. This latter station is located in Maine and provides the opportunity to compare and contrast crustal structure between a region of Paleozoic tectonics (the Appalachian belt) and the Canadian Shield. Data availability was very variable between the stations, primarily due to recording period, since data quality was universally high. Receiver functions were calculated using a multi-taper method implemented by Helffrich (2006), and Moho depths were then estimated using the H-K stacking method of Zhu & Kanamori (2000). Crustal thicknesses across the region lie predominantly in the range 33-42 km, with most Vp/Vs ratios between 1.72 and 1.84, suggesting that the bulk crust is largely felsic in nature, but with some more mafic components in certain regions. In some cases the crustal thickness estimate from H-K stacking was significantly different to values expected from other studies in the region and in the Canadian Shield as a whole. In these cases, detailed inspection of the receiver functions revealed significant back-azimuthal variation in the waveforms and significant energy on the tangential components. These characteristics suggest the presence of dipping and/or anisotropic structure beneath the stations, and more detailed modelling will be necessary to characterise the crust in these regions.

  9. Plume or no plume: Emeishan Large Igneous Province in Southwest China revisited from receiver function analysis

    NASA Astrophysics Data System (ADS)

    He, Chuansong; Santosh, M.; Wu, Jianping; Chen, Xuanhua

    2014-07-01

    The Late Permian Emeishan Large Igneous Province at the western margin of the Yangtze craton and eastern Tibet is popularly regarded as the signature of mantle plume impingement onto the lithosphere. In this study, we investigate the crustal structure and upper mantle discontinuities of this region by employing H-k stacking of receiver function and depth domain receiver function. Our results image the mantle transition zone. However, no vestiges of any mantle plume upwelling in this area are recorded in our results, and the region is characterized by a largely cold domain. In contrast, our data reveal a region of lower crustal delamination that coincides with the cold mantle transition zone. We therefore suggest that the delaminated lower crustal material was recycled into the upper mantle or the mantle transition zone, turning the latter into a cold domain. The delamination of the lower crust might have also led to asthenospheric upwelling and plume-like upwelling from the mantle transition zone that generated the basalts in the Emeishan Large Igneous Province.

  10. Prognostic Analysis for Cardiogenic Shock in Patients with Acute Myocardial Infarction Receiving Percutaneous Coronary Intervention

    PubMed Central

    Lin, Mao-Jen; Chen, Chun-Yu; Lin, Hau-De

    2017-01-01

    Cardiogenic shock (CS) is uncommon in patients suffering from acute myocardial infarction (AMI). Long-term outcome and adverse predictors for outcomes in AMI patients with CS receiving percutaneous coronary interventions (PCI) are unclear. A total of 482 AMI patients who received PCI were collected, including 53 CS and 429 non-CS. Predictors for AMI patients with CS including recurrent MI, cardiovascular (CV) mortality, all-cause mortality, and repeated-PCI were analyzed. The CS group had a lower central systolic pressure and central diastolic pressure (both P < 0.001). AMI patients with hypertension history were less prone to develop CS (P < 0.001). Calcium channel blockers and statins were less frequently used by the CS group than the non-CS group (both P < 0.05) after discharge. Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score, CV mortality, and all-cause mortality were higher in the CS group than the non-CS group (all P < 0.005). For patients with CS, stroke history was a predictor of recurrent MI (P = 0.036). CS, age, SYNTAX score, and diabetes were predictors of CV mortality (all P < 0.05). CS, age, SYNTAX score, and stroke history were predictors for all-cause mortality (all P < 0.05). CS, age, and current smoking were predictors for repeated-PCI (all P < 0.05). PMID:28251160

  11. Analysis, design, and experimental results for lightweight space heat receiver canisters, phase 1

    NASA Technical Reports Server (NTRS)

    Schneider, Michael G.; Brege, Mark A.; Heidenreich, Gary R.

    1991-01-01

    Critical technology experiments have been performed on thermal energy storage modules in support of the Brayton Advanced Heat Receiver program. The modules are wedge-shaped canisters designed to minimize the mechanical stresses that occur during the phase change of the lithium fluoride phase change material. Nickel foam inserts were used in some of the canisters to provide thermal conductivity enhancement and to distribute the void volume. Two canisters, one with a nickel foam insert, and one without, were thermally cycled in various orientations in a fluidized bed furnace. The only measurable impact of the nickel foam was seen when the back and short sides of the canister were insulated to simulate operation in the advanced receiver design. In tests with insulation, the furnace to back side delta T was larger in the canister with the nickel foam insert, probably due to the radiant absorptivity of the nickel. However, the differences in the temperature profiles of the two canisters were small, and in many cases the profiles matched fairly well. Computed Tomography (CT) was successfully used to nondestructively demarcate void locations in the canisters. Finally, canister dimensional stability, which was measured throughout the thermal cycling test program with an inspection fixture was satisfactory with a maximum change of 0.635 mm (0.025 in.).

  12. Analysis and comparison of experimental and simulated results for an omnidirectional free space optical receiver architecture

    NASA Astrophysics Data System (ADS)

    Murshid, Syed H.; Lovell, Gregory L.; Finch, Michael F.

    2014-09-01

    Lasercomm or Free Space Optical (FSO) communication has the potential to provide fiber optic data rates without the need for wired physical connectivity. This paper investigates the feasibility of an Omnidirectional FSO (O-FSO) communications link that utilizes fiber bundles for improved omni-directionality and compares experimental data with modeled results. Current state of the art O-FSO link ranges are limited to 100 meters or so, with data rates of only a few100 kbits/sec. The proposed architecture is formed from commercially available fiber bundle that collects omnidirectional light due to the hemispheric nature of the fiber bundle by exploiting the acceptance cones of the individual fiber exposed to the optical radiation. The experimental transmitter is composed of an LED source that is driven by an On-Off-Keying signal. This paper presents the received optical power while varying the range between the transmitter and receiver. The omni-directionality of this architecture is also verified. The measured results are then compared to the model predictions for omni-directionality and range.

  13. Shallow Sedimentary Structure of the Brahmaputra Valley Constraint from Receiver Functions Analysis

    NASA Astrophysics Data System (ADS)

    Saikia, Sowrav; Chopra, Sumer; Baruah, Santanu; Singh, Upendra K.

    2017-01-01

    In this study, receiver functions from ten Broadband seismograph stations on Cenozoic sediment formations of Brahmaputra valley and its neighboring region in northeastern part of India are determined. Receiver function traces from this region show delay in peak by 1-2.5 s and associated minor peaks with the direct P-phase peak. Based on such observation, we try to image sedimentary structure of the Brahmaputra valley plain, adjacent Shillong plateau and Himalayan foredeep region. An adapted hybrid global waveform inversion technique has been applied to extract sedimentary basin structure beneath each site. The sedimentary cover of the basin is about 0.5-6.5 km thick across the valley, 0.5-1.0 km on Shillong plateau and 2.0-5.0 km in nearby foredeep region. We have found that sedimentary thickness increases from SW to NE along the Brahmaputra valley and towards the Eastern Himalayan syntaxes. The estimated sediment thickness and S wave velocity structure agree well with the results of previous active source, gravity, and deep borehole studies carried out in this region. The thick crustal low velocity sediment cover in Brahmaputra valley is expected to amplify ground motions during earthquakes and therefore important for seismic hazard assessment of the region.

  14. Crustal structure in the southern part of West Java based on analysis of teleseismic receiver function

    NASA Astrophysics Data System (ADS)

    Syuhada, Anggono, Titi

    2016-02-01

    We analyzed teleseismic receiver functions from five broadband stations to determine the crustal thickness and Vp/vs ratios in the southern part of west Java. We observed that the study area is characterized by crustal thickness around 31-37 km with Vp/Vs varying between 1.66 and 1.87. We suggest that lower values of Vp/Vs obtained in some stations indicate more felsic crustal composition. The mid-crust low velocity zone is observed beneath a seismic station located near the volcanic zones with high values of Vp/Vs ratio suggesting the presence of partial melt due to geothermal activities in the upper mantle. Furthermore, a seismic station located near the active fault zone also has high Vp/Vs ratio, which may indicate the presence of fluid filled fracture zone. However, this station exhibits complicated receiver functions, thus it needs further research involving a larger dataset with good backazimuth coverage of the teleseismic data to resolve this issue.

  15. Two-condition within-participant statistical mediation analysis: A path-analytic framework.

    PubMed

    Montoya, Amanda K; Hayes, Andrew F

    2017-03-01

    Researchers interested in testing mediation often use designs where participants are measured on a dependent variable Y and a mediator M in both of 2 different circumstances. The dominant approach to assessing mediation in such a design, proposed by Judd, Kenny, and McClelland (2001), relies on a series of hypothesis tests about components of the mediation model and is not based on an estimate of or formal inference about the indirect effect. In this article we recast Judd et al.'s approach in the path-analytic framework that is now commonly used in between-participant mediation analysis. By so doing, it is apparent how to estimate the indirect effect of a within-participant manipulation on some outcome through a mediator as the product of paths of influence. This path-analytic approach eliminates the need for discrete hypothesis tests about components of the model to support a claim of mediation, as Judd et al.'s method requires, because it relies only on an inference about the product of paths-the indirect effect. We generalize methods of inference for the indirect effect widely used in between-participant designs to this within-participant version of mediation analysis, including bootstrap confidence intervals and Monte Carlo confidence intervals. Using this path-analytic approach, we extend the method to models with multiple mediators operating in parallel and serially and discuss the comparison of indirect effects in these more complex models. We offer macros and code for SPSS, SAS, and Mplus that conduct these analyses. (PsycINFO Database Record

  16. Multivariable and Multigroup Receiver Operating Characteristics Curve Analyses for Qualitative and Quantitative Analysis

    DTIC Science & Technology

    2012-01-01

    presents the original experimental data collected by Fisher and includes the lengths and widths of the sepals and petals of the three iris flower ...more than two experimental groups in a systematic fashion. The classic Fisher iris flower data set is treated as one variable and two cases at a time...enhanced computer efficiency and information-rich analysis. 15. SUBJECT TERMS Multivariate analysis Sepal Univariate analysis Petal Frequency

  17. Analytical quality assurance in veterinary drug residue analysis methods: matrix effects determination and monitoring for sulfonamides analysis.

    PubMed

    Hoff, Rodrigo Barcellos; Rübensam, Gabriel; Jank, Louise; Barreto, Fabiano; Peralba, Maria do Carmo Ruaro; Pizzolato, Tânia Mara; Silvia Díaz-Cruz, M; Barceló, Damià

    2015-01-01

    In residue analysis of veterinary drugs in foodstuff, matrix effects are one of the most critical points. This work present a discuss considering approaches used to estimate, minimize and monitoring matrix effects in bioanalytical methods. Qualitative and quantitative methods for estimation of matrix effects such as post-column infusion, slopes ratios analysis, calibration curves (mathematical and statistical analysis) and control chart monitoring are discussed using real data. Matrix effects varying in a wide range depending of the analyte and the sample preparation method: pressurized liquid extraction for liver samples show matrix effects from 15.5 to 59.2% while a ultrasound-assisted extraction provide values from 21.7 to 64.3%. The matrix influence was also evaluated: for sulfamethazine analysis, losses of signal were varying from -37 to -96% for fish and eggs, respectively. Advantages and drawbacks are also discussed considering a workflow for matrix effects assessment proposed and applied to real data from sulfonamides residues analysis.

  18. Precambrian Crustal Evolution of the Hudson Bay Region: Insights from Receiver Function Analysis (Invited)

    NASA Astrophysics Data System (ADS)

    Thompson, D. A.; Bastow, I. D.; Helffrich, G. R.; Kendall, J. M.; Wookey, J.; Snyder, D. B.; Eaton, D. W.

    2009-12-01

    The processes that formed, thickened and thinned the early Earth's crust remain poorly known. The onset of modern plate tectonics, for example, could be as far back as the Hadean or as late as the Neoproterozoic. In many cratons, vertical processes are believed to have been dominant (dome-and-keel tectonics, e.g. Pilbara craton), while others are hypothesised to have formed by the progressive accretion of different terranes (e.g. Superior craton). The Hudson Bay region represents one of the largest areas of Precambrian geology on the planet, with ages spanning 2 billion years (3.9-1.8 Ga). The western Churchill province contains the predominantly Paleo- to Mesoarchean Rae domain and the Neoarchean Hearne domain, and is welded to the Superior craton by the Paleoproterozoic Trans-Hudson Orogen, a Himalayan scale feature which extends for more than 4500 km along strike. The Churchill has received comparatively little scientific investigation due to its remote location and harsh climate. In order to test hypotheses on crustal formation and evolution during the Precambrian, teleseismic receiver functions have been analysed for more than 30 stations located on the key geological features in the vicinity of Hudson Bay. Across the entire Rae domain, a dominantly felsic crust with a sharp Moho is observed. Little evidence exists to interpret the vast extent of the felsic crust in terms of subduction related processes. Within the granite-greenstone terranes of the Hearne domain, a more intermediate bulk composition and complex Moho signature may be representative of an oceanic affinity for the crust, suggesting accretionary processes acted there. In the Quebec-Baffin Island region, bulk crustal Vp/Vs ratios are dominated by effects associated with the Trans-Hudson Orogen, and appear to map out the first-order shape of the indenting lower-plate. Correlation between terrane age and receiver function-derived crustal structure suggests that the crust in northern Canada was

  19. Spine Radiosurgery: A Dosimetric Analysis in 124 Patients Who Received 18 Gy

    SciTech Connect

    Schipani, Stefano; Wen, Winston; Jin, Jain-Yue; Kim, Jin Koo; Ryu, Samuel

    2012-12-01

    Purpose: To define the safely tolerated doses to organs at risk (OARs) adjacent to the target volume (TV) of spine radiosurgery (SRS) with 18-Gy in a single fraction. Methods and Materials: A total of 124 patient cases with 165 spine metastases were reviewed. An 18-Gy single-fraction regimen was prescribed to the 90% isodose line encompassing the TV. A constraint of 10 Gy to 10% of the spinal cord outlined 6 mm above and below the TV was used. Dosimetric data to OARs were analyzed. Results: A total of 124 patients (100%) were followed-up, and median follow-up time was 7 months (1-50 months). Symptoms and local control were achieved in 114 patients (92%). Acute Radiation Therapy Oncology Group (RTOG) grade 1 oral mucositis occurred in 11 of 11 (100%) patients at risk for oropharyngeal toxicity after cervical spine treatment. There were no RTOG grade 2-4 acute or late complications. Median TV was 43.2 cc (5.3-175.4 cc) and 90% of the TV received median dose of 19 Gy (17-19.8 Gy). Median (range) of spinal cord maximum dose (Dmax), dose to spinal cord 0.35 cc (Dsc0.35), and cord volume receiving 10 Gy (Vsc10) were 13.8 Gy (5.4-21 Gy), 8.9 Gy (2.6-11.4 Gy) and 0.33 cc (0-1.6 cc), respectively. Other OARs were evaluated when in proximity to the TV. Esophagus (n=58), trachea (n=28), oropharynx (n=11), and kidneys (n=34) received median (range) V10 and V15 of 3.1 cc (0-5.8 cc) and 1.2 cc (0-2.9 cc), 2.8 cc (0-4.9 cc), and 0.8 cc (0-2.1 cc), 3.4 cc (0-6.2 cc) and 1.6 cc (0-3.2 cc), 0.3 cc (0-0.8 cc) and 0.08 cc (0-0.1 cc), respectively. Conclusions: Cord Dmax of 14 Gy and D0.35 of 10 Gy are safe dose constraints for 18-Gy single-fraction SRS. Esophagus V10 of 3 cc and V15 of 1 cc, trachea V10 of 3 cc, and V15 of 1 cc, oropharynx V10 of 3.5 cc and V15 of 1.5 cc, kidney V10 of 0.3 cc, and V15 of 0.1 cc are planning guidelines when these OARs are in proximity to the TV.

  20. Visual analytics for multimodal social network analysis: a design study with social scientists.

    PubMed

    Ghani, Sohaib; Kwon, Bum Chul; Lee, Seungyoon; Yi, Ji Soo; Elmqvist, Niklas

    2013-12-01

    Social network analysis (SNA) is becoming increasingly concerned not only with actors and their relations, but also with distinguishing between different types of such entities. For example, social scientists may want to investigate asymmetric relations in organizations with strict chains of command, or incorporate non-actors such as conferences and projects when analyzing coauthorship patterns. Multimodal social networks are those where actors and relations belong to different types, or modes, and multimodal social network analysis (mSNA) is accordingly SNA for such networks. In this paper, we present a design study that we conducted with several social scientist collaborators on how to support mSNA using visual analytics tools. Based on an openended, formative design process, we devised a visual representation called parallel node-link bands (PNLBs) that splits modes into separate bands and renders connections between adjacent ones, similar to the list view in Jigsaw. We then used the tool in a qualitative evaluation involving five social scientists whose feedback informed a second design phase that incorporated additional network metrics. Finally, we conducted a second qualitative evaluation with our social scientist collaborators that provided further insights on the utility of the PNLBs representation and the potential of visual analytics for mSNA.

  1. Spatio-temporal analysis of industrial composition with IVIID: an interactive visual analytics interface for industrial diversity

    NASA Astrophysics Data System (ADS)

    Mack, Elizabeth A.; Zhang, Yifan; Rey, Sergio; Maciejewski, Ross

    2014-04-01

    The industrial composition of places has received considerable attention because of the widespread belief that industrial diversity buffers regional economies from economic shocks. Subsequently, a variety of toolkits and indices have been developed with the goal of better capturing the compositional dynamics of regions. Although useful, a key drawback of these indices is their static nature, which limits the utility of these indices in a space-time context. This paper provides an overview of and applications of an interface called interactive visualization tool for indices of industrial diversity, which is a visual analytics tool developed specifically for the analysis and visualization of local measures of industrial composition for areal data. This overview will include a discussion of its key features, as well as a demonstration of the utility of the interface in exploring questions surrounding diversity and the dynamic nature of composition through space and time. A focus of this demonstration is to highlight how the interactivity and query functionality of this interface overcome several of the obstacles to understanding composition through space and time that prior toolkits and comparative static approaches have been unable to address.

  2. Analytical thresholds and sensitivity: establishing RFU thresholds for forensic DNA analysis.

    PubMed

    Bregu, Joli; Conklin, Danielle; Coronado, Elisse; Terrill, Margaret; Cotton, Robin W; Grgicak, Catherine M

    2013-01-01

    Determining appropriate analytical thresholds (ATs) for forensic DNA analysis is critical to maximize allele detection. In this study, six methods to determine ATs for forensic DNA purposes were examined and compared. Four of the methods rely on analysis of the baseline noise of a number of negatives, while two utilize the relationship between relative fluorescence unit signal and DNA input in the polymerase chain reaction (PCR) derived from a dilution series ranging from 1 to 0.06 ng. Results showed that when a substantial mass of DNA (i.e., >1 ng) was amplified, the baseline noise increased, suggesting the application of an AT derived from negatives should only be applied to samples with low levels of DNA. Further, the number and intensity of these noise peaks increased with increasing injection times, indicating that to maximize the ability to detect alleles, ATs should be validated for each post-PCR procedure employed.

  3. Analysis of heterogeneity in molecular weight and shape by analytical ultracentrifugation using parallel distributed computing.

    PubMed

    Demeler, Borries; Brookes, Emre; Nagel-Steger, Luitgard

    2009-01-01

    A computational approach for fitting sedimentation velocity experiments from an analytical ultracentrifuge in a model-independent fashion is presented. This chapter offers a recipe for obtaining high-resolution information for both the shape and the molecular weight distributions of complex mixtures that are heterogeneous in shape and molecular weight and provides suggestions for experimental design to optimize information content. A combination of three methods is used to find the solution most parsimonious in parameters and to verify the statistical confidence intervals of the determined parameters. A supercomputer implementation with a MySQL database back end is integrated into the UltraScan analysis software. The UltraScan LIMS Web portal is used to perform the calculations through a Web interface. The performance and limitations of the method when employed for the analysis of complex mixtures are demonstrated using both simulated data and experimental data characterizing amyloid aggregation.

  4. Analytical modeling and thermodynamic analysis of robust superhydrophobic surfaces with inverse-trapezoidal microstructures.

    PubMed

    Im, Maesoon; Im, Hwon; Lee, Joo-Hyung; Yoon, Jun-Bo; Choi, Yang-Kyu

    2010-11-16

    A polydimethylsiloxane (PDMS) elastomer surface with perfectly ordered microstructures having an inverse-trapezoidal cross-sectional profile (simply PDMS trapezoids) showed superhydrophobic and transparent characteristics under visible light as reported in our previous work. The addition of a fluoropolymer (Teflon) coating enhances both features and provides oleophobicity. This paper focuses on the analytical modeling of the fabricated PDMS trapezoids structure and thermodynamic analysis based on the Gibbs free energy analysis. Additionally, the wetting characteristics of the fabricated PDMS trapezoids surface before and after the application of the Teflon coating are analytically explained. The Gibbs free energy analysis reveals that, due to the Teflon coating, the Cassie-Baxter state becomes energetically more favorable than the Wenzel state and the contact angle difference between the Cassie-Baxter state and the Wenzel state decreases. These two findings support the robustness of the superhydrophobicity of the fabricated Teflon-coated PDMS trapezoids. This is then verified via the impinging test of a water droplet at a high speed. The dependencies of the design parameters in the PDMS trapezoids on the hydrophobicity are also comprehensively studied through a thermodynamic analysis. Geometrical dependency on the hydrophobicity shows that overhang microstructures do not have a significant influence on the hydrophobicity. In contrast, the intrinsic contact angle of the structural material is most important in determining the apparent contact angle. On the other hand, the experimental results showed that the side angles of the overhangs are critical not for the hydrophobic but for the oleophobic property with liquids of a low surface tension. Understanding of design parameters in the PDMS trapezoids surface gives more information for implementation of superhydrophobic surfaces.

  5. Analysis and design of a 1.8-2.7 GHz tunable 8-band TDD LTE receiver front-end

    NASA Astrophysics Data System (ADS)

    Xiao, Wang; Yuji, Wang; Weiwei, Wang; Xuegui, Chang; Na, Yan; Xi, Tan; Hao, Min

    2011-05-01

    This paper describes the analysis and design of a 0.13 μm CMOS tunable receiver front-end that supports 8 TDD LTE bands, covering the 1.8-2.7 GHz frequency band and supporting the 5/10/15/20 MHz bandwidth and QPSK/16QAM/64QAM modulation schemes. The novel zero-IF receiver core consists of a tunable narrowband variable gain low-noise amplifier (LNA), a current commutating passive down-conversion mixer with a 2nd order low pass trans-impedance amplifier, an LO divider, a rough gain step variable gain pre-amplifier, a tunable 4th order Chebyshev channel select active-RC low pass filter with cutoff frequency calibration circuit and a fine gain step variable gain amplifier. The LNA can be tuned by reconfiguring the output parallel LC tank to the responding frequency band, eliminating the fixed center frequency multiple LNA array for a multi-mode receiver. The large various gain range and bandwidth of the analog baseband can also be tuned by digital configuration to satisfy the specification requirement of various bandwidth and modulation schemes. The test chip is implemented in an SMIC 0.13 μm 1P8M CMOS process. The full receiver achieves 4.6 dB NF, -14.5 dBm out of band IIP3, 30-94 dB gain range and consumes 54 mA with a 1.2 V power supply.

  6. Crustal thickness estimation in the Maule Region (Chile) from P-wave receiver function analysis

    NASA Astrophysics Data System (ADS)

    Dannowski, A.; Grevemeyer, I.; Thorwart, M. M.; Rabbel, W.; Flueh, E. R.

    2010-12-01

    A temporary passive seismic network of 31 broad-band stations was deployed in the region around Talca and Constitución between 35°S to 36°S latitude and 71°W to 72.5°W longitude. The network was operated between March and October 2008. Thus, we recorded data prior the magnitude Mw=8.8 earthquake of 27 February 2010 at a latitude of the major slip and surface uplift. The experiment was conducted to address fundamental questions on deformation processes, crustal and mantle structures, and fluid flow. We present first results of a teleseismic P receiver function study that covers the coastal region and reaches to the Andes. The aim is to determine the structure and thickness of the continental crust and constrain the state of hydration of the mantle wedge. The P-wave receiver function technique requires large teleseismic earthquakes from different distances and backazimuths. A few percent of the incident P-wave energy from a teleseismic event will be converted into S-wave (Ps) at significant and relatively sharp discontinuities beneath the station. A small converted S phase is produced that arrives at the station within the P wave coda directly after the direct P-wave. The converted Ps phase and their crustal multiples contain information about crustal properties, such as Moho depth and the crustal vp/vs ratio. We use teleseismic events with magnitudes mb > 5.5 at epicentral distances between 30° and 95° to examine P-to-S converted seismic phases. Our preliminary results provide new information about the thickness of the continental crust beneath the coastal region in Central Chile. At most of the stations we observed significant energy from P to S converted waves between 4 and 5 s after the direct P-wave within a positive phase interpreted as the Moho, occurring at 35 to 40 km. Thus, the great Maule earthquake of 27 February 2010 nucleated up-dip of the continental Moho and hence ruptured along a plate contact between subducted sediments and continental crust

  7. Analytics for Education

    ERIC Educational Resources Information Center

    MacNeill, Sheila; Campbell, Lorna M.; Hawksey, Martin

    2014-01-01

    This article presents an overview of the development and use of analytics in the context of education. Using Buckingham Shum's three levels of analytics, the authors present a critical analysis of current developments in the domain of learning analytics, and contrast the potential value of analytics research and development with real world…

  8. Structure of the Los Angeles Basin from Ambient Noise and Receiver Function Analysis

    NASA Astrophysics Data System (ADS)

    Clayton, R. W.; Ma, Y.; Cochran, E. S.

    2015-12-01

    We show the results from the LASSIE seismic experiment, which consists of a dense (1-km spacing) linear array of broadband stations deployed across the LA basin for approximately two months. Two common methods - ambient noise and receiver function (RF) - are applied to determine the velocity and structure of the basin. The basin RFs are complicated, however, the dense array enhances the lateral coherence of the signals and allows the structure to be imaged. The basement shape is clearly shown in the migrated image of the PpPs phase. The Ps conversion at the basement is the largest signal (including the direct wave) in the first 3 s. However, the Ps phase does not form as clear an image compared with the PpPs phase, possibly due to a requirement of more accurate velocity model. The surface wave signals from the ambient noise cross-correlations between LASSIE and surrounding SCSN stations are used for velocity inversion. A linear Dix-type inversion (Haney and Tsai, 2015, Geophysics) is applied to the extracted dispersion curves. The 1-10 s period Rayleigh wave and the 1-8 s period Love wave dispersion curves provide excellent constraints on top 5 km SV and top 3 km SH velocity structures respectively. Strong anisotropy (SV > SH) is observed for the top 1 km, and we plan to use this result to infer the fracture orientation and density of the shallow sedimentary rocks.

  9. Outcomes for adult scoliosis patients receiving chiropractic rehabilitation: a 24-month retrospective analysis

    PubMed Central

    Morningstar, Mark W.

    2011-01-01

    Objectives The purpose of this study was to retrospectively report the results of patients who completed an exercise-based chiropractic program and its potential to alter the natural progression of adult scoliosis at 24 months after the clinic portion of treatment was concluded. Methods A retrospective chart review was conducted at 2 spine clinics in Michigan, USA. Each clinic uses the same chiropractic rehabilitation program to treat patients with adult scoliosis. Multidimensional patient outcomes included radiographic, respiratory, disability, and pain parameters. Outcomes were measured at baseline, at end of active treatment, and at long-term follow-up. Results A total of 28 patients fit the inclusion criteria for the study. The average beginning primary Cobb angle was 44° ± 6°. Patients received the same chiropractic rehabilitation program for approximately 6 months. At the end of active treatment, improvements were recorded in Cobb angle, pain scores, spirometry, and disability rating. All radiographic findings were maintained at 24-month follow-up. Conclusion This report is among the first to demonstrate sustained radiographic, self-rated, and physiologic benefits after treatment ceased. After completion of a multimodal chiropractic rehabilitation treatment, a retrospective cohort of 28 adult scoliosis patients reported improvements in pain, Cobb angle, and disability immediately following the conclusion of treatment and 24 months later. PMID:22014907

  10. A simulation analysis of phase processing circuitry in the Ohio University Omega receiver prototype

    NASA Technical Reports Server (NTRS)

    Palkovic, R. A.

    1975-01-01

    A FORTRAN IV simulation study of the all-digital phase-processing circuitry is described. A digital phase-lock loop (DPLL) forms the heart of the Omega navigation receiver prototype, and through the DPLL, the phase of the 10.2 KHz Omega signal was estimated when the true signal phase is contaminated with noise. The DPLL uses a frequency synthesizer as the reference oscillator. The synthesizer is composed of synchronous rate multipliers (SRM's) driven by a temperature-compensated crystal oscillator, and the use of the SRM's in this application introduces phase jitter which degrades system performance. Simulation of the frequency synthesizer discussed was to analyze the circuits on a bit-by-bit level in order to evaluate the overall design, to see easily the effects of proposed design changes prior to actual breadboarding, to determine the optimum integration time for the DPLL in an environment typical of general aviation conditions, and to quantify the phase error introduced by the SRM synthesizer and examine its effect on the system.

  11. Topological data analysis: A promising big data exploration tool in biology, analytical chemistry and physical chemistry.

    PubMed

    Offroy, Marc; Duponchel, Ludovic

    2016-03-03

    An important feature of experimental science is that data of various kinds is being produced at an unprecedented rate. This is mainly due to the development of new instrumental concepts and experimental methodologies. It is also clear that the nature of acquired data is significantly different. Indeed in every areas of science, data take the form of always bigger tables, where all but a few of the columns (i.e. variables) turn out to be irrelevant to the questions of interest, and further that we do not necessary know which coordinates are the interesting ones. Big data in our lab of biology, analytical chemistry or physical chemistry is a future that might be closer than any of us suppose. It is in this sense that new tools have to be developed in order to explore and valorize such data sets. Topological data analysis (TDA) is one of these. It was developed recently by topologists who discovered that topological concept could be useful for data analysis. The main objective of this paper is to answer the question why topology is well suited for the analysis of big data set in many areas and even more efficient than conventional data analysis methods. Raman analysis of single bacteria should be providing a good opportunity to demonstrate the potential of TDA for the exploration of various spectroscopic data sets considering different experimental conditions (with high noise level, with/without spectral preprocessing, with wavelength shift, with different spectral resolution, with missing data).

  12. A Bayesian Hierarchical Non-Linear Regression Model in Receiver Operating Characteristic Analysis of Clustered Continuous Diagnostic Data

    PubMed Central

    Zou, Kelly H.; O’Malley, A. James

    2005-01-01

    Receiver operating characteristic (ROC) analysis is a useful evaluative method of diagnostic accuracy. A Bayesian hierarchical nonlinear regression model for ROC analysis was developed. A validation analysis of diagnostic accuracy was conducted using prospective multi-center clinical trial prostate cancer biopsy data collected from three participating centers. The gold standard was based on radical prostatectomy to determine local and advanced disease. To evaluate the diagnostic performance of PSA level at fixed levels of Gleason score, a normality transformation was applied to the outcome data. A hierarchical regression analysis incorporating the effects of cluster (clinical center) and cancer risk (low, intermediate, and high) was performed, and the area under the ROC curve (AUC) was estimated. PMID:16161801

  13. NaK pool-boiler bench-scale receiver durability test: Test results and materials analysis

    SciTech Connect

    Andraka, C.E.; Goods, S.H.; Bradshaw, R.W.; Moreno, J.B.; Moss, T.A.; Jones, S.A.

    1994-06-01

    Pool-boiler reflux receivers have been considered as an alternative to heat pipes for the input of concentrated solar energy to Stirling-cycle engines in dish-Stirling electric generation systems. Pool boilers offer simplicity in design and fabrication. The operation of a full-scale pool-boiler receiver has been demonstrated for short periods of time. However, to generate cost-effective electricity, the receiver must operate Without significant maintenance for the entire system life, as much as 20 to 30 years. Long-term liquid-metal boiling stability and materials compatibility with refluxing NaK-78 is not known and must be determined for the pool boiler receiver. No boiling system has been demonstrated for a significant duration with the current porous boiling enhancement surface and materials. Therefore, it is necessary to simulate the full-scale pool boiler design as much as possible, including flux levels, materials, and operating cycles. On-sun testing is impractical because of the limited test time available. A test vessel was constructed with a porous boiling enhancement surface. The boiling surface consisted of a brazed stainless steel powder with about 50% porosity. The vessel was heated with a quartz lamp array providing about go W/CM2 peak incident thermal flux. The vessel was charged with NaK-78. This allows the elimination of costly electric preheating, both on this test and on fullscale receivers. The vessel was fabricated from Haynes 230 alloy. The vessel operated at 750{degrees}C around the clock, with a 1/2-hour shutdown cycle to ambient every 8 hours. The test completed 7500 hours of lamp-on operation time, and over 1000 startups from ambient. The test was terminated when a small leak in an Inconel 600 thermowell was detected. The test design and data are presented here. Metallurgical analysis of virgin and tested materials has begun, and initial results are also presented.

  14. Hybrid Analytical Technique for Nonlinear Vibration Analysis of Thin-Walled Beams

    NASA Technical Reports Server (NTRS)

    Noor, Ahmed K.; Hadian, Jafar M.; Andersen, Carl M.

    1993-01-01

    A two-step hybrid analytical technique is presented for the nonlinear vibration analysis of thin-walled beams. The first step involves the generation of various-order perturbation functions using the Linstedt-Poincare perturbation technique. The second step consists of using the perturbation functions as coordinate (or approximation) functions and then computing both the amplitudes of these functions and the nonlinear frequency of vibration via a direct variational procedure. The analytical formulation is based on a form of the geometrically nonlinear beam theory with the effects of in-plane inertia, rotatory inertia, and transverse shear deformation included. The effectiveness of the proposed technique is demonstrated by means of a numerical example of thin-walled beam with a doubly symmetric I-section. The solutions obtained using a single-spatial mode were compared with those obtained using multiple-spatial modes. The standard of comparison was taken to be the frequencies obtained by the direct integration/fast Fourier transform (FFT) technique. The nonlinear frequencies obtained by the hybrid technique were shown to converge to the corresponding ones obtained by the direct integration/fast Fourier transform (FFT) technique well beyond the range of applicability of the perturbation technique. The frequencies and total strain energy of the beam were overestimated by using a single-spatial mode.

  15. An analysis of beam parameters on proton-acoustic waves through an analytic approach.

    PubMed

    Aytac Kipergil, Esra; Erkol, Hakan; Kaya, Serhat; Gulsen, Gultekin; Unlu, Mehmet

    2017-03-02

    It has been reported that acoustic waves are generated when a high energy pulsed proton beam is deposited in a small volume within tissue. One possible application of the proton induced acoustics is to get a real-time feedback for intratreatment adjustments by monitoring such acoustic waves. High spatial resolution in ultrasound imaging may reduce proton range uncertainty. Thus, it is crucial to understand the dependence of the acoustic waves on the proton beam characteristics. In this manuscript, firstly, an analytic solution to the proton induced acoustic wave is presented to reveal the dependence of signal on beam parameters, and then combined with an analytic approximation of the Bragg curve. The influence of the beam energy, pulse duration, and beam diameter variation on the acoustic waveform are investigated. Further analysis is performed regarding the Fourier decomposition of proton-acoustic signals. Our results show that smaller spill time of proton beam upsurges the amplitude of acoustic wave for constant number of protons, and hence beneficial for dose monitoring. The increase in the energy of each individual proton in the beam leads to spatial broadening of the Bragg curve, which also yields acoustic waves of greater amplitude. The pulse duration and the beam width of the proton beam do not affect the central frequency of the acoustic wave, but they change the amplitude of the spectral components.

  16. The Challenge of Understanding Process in Clinical Behavior Analysis: The Case of Functional Analytic Psychotherapy

    PubMed Central

    Follette, William C; Bonow, Jordan T

    2009-01-01

    Whether explicitly acknowledged or not, behavior-analytic principles are at the heart of most, if not all, empirically supported therapies. However, the change process in psychotherapy is only now being rigorously studied. Functional analytic psychotherapy (FAP; Kohlenberg & Tsai, 1991; Tsai et al., 2009) explicitly identifies behavioral-change principles used to bring about therapeutic improvements in adult outpatients whose clinical problems stem from ineffective interpersonal repertoires. These principles include contingent responding to behavioral excesses and deficits by a therapist who has established him- or herself as a salient source of social reinforcement. Empirical support for FAP is emerging, but a variety of pragmatic and theoretical questions warrant investigation. Among the issues described in this paper are the training and dissemination of procedures for how to conduct a functional analysis, how to train therapists to identify functional stimulus classes, how to best address decreasing problem behavior without creating an aversive environment, how to enhance generalization, and how to account for the principle of equifinality when trying to specify therapeutic procedures. These and other issues stem largely from trying to disseminate a behavioral principle-based intervention rather than a topographically specified intervention. These issues present challenges and research opportunities for applied clinical behavior analysts if they wish to extend their science to address clinical issues important to the treatment of adult outpatients with normal intellectual functioning. PMID:22478517

  17. Latent Class Analysis of Conduct Problems of Elementary Students Receiving Special Education Services

    ERIC Educational Resources Information Center

    Toupin, Jean; Déry, Michèle; Verlaan, Pierrette; Lemelin, Jean-Pascal; Lecocq, Aurélie; Jagiellowicz, Jadwiga

    2016-01-01

    Students with conduct problems (CPs) may present heterogeneity in terms of behavioral manifestations and service needs. Previous studies using Latent Class Analysis (LCA) to capture this heterogeneity have been conducted mostly with community samples and have often applied a narrow definition of CP. Considering this context, this study…

  18. Automated Tools for Test and Analysis of Radar Warning Receiver Software.

    DTIC Science & Technology

    1982-12-01

    software requirements for the Data Extraction and Analysis system. The requirements were derived from the user, environmental , and other requirements...transform[rwr] := RWR ’ transform~ quiti : ’QUIT repeat helplevel =min; good..input :-false; (loop until valid command) while not good-..input do begin write

  19. An analysis of eco-environmental impacts of the south-to-north water transfer project on the receiving areas

    NASA Astrophysics Data System (ADS)

    Wang, Lin; Gan, Hong; Xiao, Yuquan; You, Jinjun

    2010-05-01

    The receiving areas of the Phase I projects of the eastern and central routes of the South-to-North Water Transfer Project cover 41 administrative regions at and above the prefecture level in the provincial level administrative regions of Beijing, Tianjin, Hebei, Shandong and Henan, and have a carrying capacity of water resources most unadaptive to the needs by the economic and social development. Those areas have densely distributed population, farmland and agricultural and industrial activities and are experiencing rapid urbanization, but suffer from high scarcity of water resources, with all the cities in the areas seeing water shortage to a varying extent. Most of the cities are relying on abstracting deep groundwater and occupying agricultural water for urban water supply. In December 2002, the State Council officially approved the General Plan on the South-to-North Water Transfer Project, which provides multiple measures to reduce groundwater over-abstraction and improve and gradually restore the eco-environment in the receiving areas by using transferred water to replace the agricultural water occupied by urban water supply and the eco-environmental water occupied by cities and agriculture. What changes have occurred to the eco-environment and urban water use in the receiving areas in recent years ? How much water can be returned from the cities to agriculture and ecology after the objectives of water supply are met? What can be achieved in the control of groundwater abstraction? What level of guarantee can the water transfer provide for agricultural water use in a dry year? All of those issues have been at the focus of public attention. In this paper, statistical analysis is made on the eco-environmental status and urban water use of 72 cities in the receiving areas of the Phase I projects since year 2000 and a conclusion is drawn that the renewal capacity of the eco-environment and groundwater in the receiving areas is deteriorating. Then the water

  20. Thermal analysis of void cavity for heat pipe receiver under microgravity

    NASA Astrophysics Data System (ADS)

    Gui, Xiaohong; Song, Xiange; Nie, Baisheng

    2017-04-01

    Based on theoretical analysis of PCM (Phase Change Material) solidification process, the model of improved void cavity distribution tending to high temperature region is established. Numerical results are compared with NASA (National Aeronautics and Space Administration) results. Analysis results show that the outer wall temperature, the melting ratio of PCM and the temperature gradient of PCM canister, have great difference in different void cavity distribution. The form of void distribution has a great effect on the process of phase change. Based on simulation results under the model of improved void cavity distribution, phase change heat transfer process in thermal storage container is analyzed. The main goal of the improved designing for PCM canister is to take measures in reducing the concentration distribution of void cavity by adding some foam metal into phase change material.

  1. An Analysis of Coherent and Differentially Coherent Digital Receivers in the Presence of Colored Noise Interference

    DTIC Science & Technology

    1986-09-01

    Offset Quadrature Phase Shift Keying ( OQPSK ) and Minimum Shift Keying (MSK). The analysis presented here ser\\as only to highlight 11 iJ-’J^’iM...SHIFT KEYING Quadrature Phase Shift Keyed (QPSK) modulation is a special case of MPSK modulation where M = 4. Offset QPSK ( OQPSK ) is a special case...furthermore a special case of OQPSK in which sinusoidal pulse weighting prior to carrier modulation produces a more compact signal spectrum making

  2. Quantitative multivariate analytical strategy for paleoenvironmental analysis of mixed benthic foraminiferal assemblages

    SciTech Connect

    Lagoe, M.B. )

    1991-03-01

    Fossil assemblages of benthic foraminifera commonly contain taxa that were not associated together during life. A variety of processes act to modify living assemblages during the transition to fossil assemblages-transport of tests by traction and gravity currents, taphonomic filtering, and rapid shifting of environments in response to sea level fluctuations, to name a few. Unraveling the nature of faunal mixing can provide insights into depositional processes and paleoenvironmental history of particular lithofacies. A quantitative multivariate analytical strategy is presented to address these problems, using the late Cenozoic Yakataga Formation, Gulf of Alaska as a specific example. A variety of lithofacies are present within the Yakataga Formation including normal marine mudstones, sandstones, coquinas and conglomerates and glaciomarine diamictites. Comparison of fossil assemblages with modern foraminiferal distributions indicates significant faunal mixing in most lithofacies, particularly the diamictites. Quantitative analysis includes cluster analysis to define broad patterns in faunal similarity, R-mode factor analysis to define species interrelationships, and Q-mode polytopic vector analysis to 'unmix' the assemblages into their component biofacies. Two broad patterns of faunal mixing are identified: (1) comprehensive mixing of all possible biofacies within a particular bathymetric range and (2) mixing of very shallow (innermost neritic) with deeper (upper bathyal) assemblages, bypassing environments from outer neritic areas. Diamictites are shown to form in a variety of water depths from inner neritic to upper bathyal.

  3. A guide to genome-wide association analysis and post-analytic interrogation.

    PubMed

    Reed, Eric; Nunez, Sara; Kulp, David; Qian, Jing; Reilly, Muredach P; Foulkes, Andrea S

    2015-12-10

    This tutorial is a learning resource that outlines the basic process and provides specific software tools for implementing a complete genome-wide association analysis. Approaches to post-analytic visualization and interrogation of potentially novel findings are also presented. Applications are illustrated using the free and open-source R statistical computing and graphics software environment, Bioconductor software for bioinformatics and the UCSC Genome Browser. Complete genome-wide association data on 1401 individuals across 861,473 typed single nucleotide polymorphisms from the PennCATH study of coronary artery disease are used for illustration. All data and code, as well as additional instructional resources, are publicly available through the Open Resources in Statistical Genomics project: http://www.stat-gen.org.

  4. An Analytic Approximation to Very High Specific Impulse and Specific Power Interplanetary Space Mission Analysis

    NASA Technical Reports Server (NTRS)

    Williams, Craig Hamilton

    1995-01-01

    A simple, analytic approximation is derived to calculate trip time and performance for propulsion systems of very high specific impulse (50,000 to 200,000 seconds) and very high specific power (10 to 1000 kW/kg) for human interplanetary space missions. The approach assumed field-free space, constant thrust/constant specific power, and near straight line (radial) trajectories between the planets. Closed form, one dimensional equations of motion for two-burn rendezvous and four-burn round trip missions are derived as a function of specific impulse, specific power, and propellant mass ratio. The equations are coupled to an optimizing parameter that maximizes performance and minimizes trip time. Data generated for hypothetical one-way and round trip human missions to Jupiter were found to be within 1% and 6% accuracy of integrated solutions respectively, verifying that for these systems, credible analysis does not require computationally intensive numerical techniques.

  5. Stable semi-analytical method for analysis of plasmonic propagation on periodically patterned metal plates

    NASA Astrophysics Data System (ADS)

    Yasrebi, Navid; Khorasani, Sina; Karami-Taheri, Hossein; Rashidian, Bizhan; Hosseini, Amir

    2010-02-01

    The need for antennas with improved characteristics for communication and radar applications has resulted in an ever-increasing demand for research in the field of high impedance surfaces, which can work as an artificial magnetic conductor. One method in fabrication of these surfaces is formation of a metamaterial by patterning a metallic surface in the shape of space filling curves (e.g. Hilbert or Peanu Curves). In this paper, we present a novel semi-analytical solution to the problem of plasmonic propagation on these surfaces. The method is based on a previously presented Green's function formalism, which has been reported in an earlier paper of ours. We have modified and improved the method for analysis of periodic structures with a large number of spatial harmonics, and used different methods to get the necessary stabilization. Here propagating modes of different structures and their corresponding frequencies are calculated, and the possibility of frequency gap formation and stability of the method are investigated.

  6. The analytic solution of the structural analysis problem and its use in structural synthesis

    NASA Astrophysics Data System (ADS)

    Fuchs, M. B.

    An overview is presented of the analytic expressions for the inverse of the stiffness matrix, the nodal displacements, and the internal forces in linear elastic redundant structures. The inverse of the stiffness matrix and the nodal displacements are obtained using Binet and Cauchy's theorem on the product of compound matrices. The formula for the internal forces is derived from the principles of structural mechanics. This approach is shown to apply to all framed structures via the unimodal stiffnesses of its elements. Approximate models are constructed which are exact at preselected points along a line in the analysis space. An argument is also made for the use of multilinear polynomials as an alternative to Taylor expansion-based approximations.

  7. Regime Transition in Electromechanical Fluid Atomization and Implications to Analyte Ionization for Mass Spectrometric Analysis

    PubMed Central

    Forbes, Thomas P.; Degertekin, F. Levent; Fedorov, Andrei G.

    2015-01-01

    The physical processes governing the transition from purely mechanical ejection to electromechanical ejection to electrospraying are investigated through complementary scaling analysis and optical visualization. Experimental characterization and visualization are performed with the ultrasonically-driven array of micromachined ultrasonic electrospray (AMUSE) ion source to decouple the electrical and mechanical fields. A new dimensionless parameter, the Fenn number, is introduced to define a transition between the spray regimes, in terms of its dependence on the characteristic Strouhal number for the ejection process. A fundamental relationship between the Fenn and Strouhal numbers is theoretically derived and confirmed experimentally in spraying liquid electrolytes of different ionic strength subjected to a varying magnitude electric field. This relationship and the basic understanding of the charged droplet generation physics have direct implications on the optimal ionization efficiency and mass spectrometric response for different types of analytes. PMID:20729096

  8. Analytical Study of Performance of Linear Discriminant Analysis in Stochastic Settings

    PubMed Central

    Hua, Jianping; Dougherty, Edward R.

    2013-01-01

    This paper provides exact analytical expressions for the first and second moments of the true error for linear discriminant analysis (LDA) when the data are univariate and taken from two stochastic Gaussian processes. The key point is that we assume a general setting in which the sample data from each class do not need to be identically distributed or independent within or between classes. We compare the true errors of designed classifiers under the typical i.i.d. model and when the data are correlated, providing exact expressions and demonstrating that, depending on the covariance structure, correlated data can result in classifiers with either greater error or less error than when training with uncorrelated data. The general theory is applied to autoregressive and moving-average models of the first order, and it is demonstrated using real genomic data. PMID:24039299

  9. Regime transition in electromechanical fluid atomization and implications to analyte ionization for mass spectrometric analysis.

    PubMed

    Forbes, Thomas P; Degertekin, F Levent; Fedorov, Andrei G

    2010-11-01

    The physical processes governing the transition from purely mechanical ejection to electromechanical ejection to electrospraying are investigated through complementary scaling analysis and optical visualization. Experimental characterization and visualization are performed with the ultrasonically-driven array of micromachined ultrasonic electrospray (AMUSE) ion source to decouple the electrical and mechanical fields. A new dimensionless parameter, the Fenn number, is introduced to define a transition between the spray regimes, in terms of its dependence on the characteristic Strouhal number for the ejection process. A fundamental relationship between the Fenn and Strouhal numbers is theoretically derived and confirmed experimentally in spraying liquid electrolytes of different ionic strength subjected to a varying magnitude electric field. This relationship and the basic understanding of the charged droplet generation physics have direct implications on the optimal ionization efficiency and mass spectrometric response for different types of analytes.

  10. Dynamic Graph Analytic Framework (DYGRAF): greater situation awareness through layered multi-modal network analysis

    NASA Astrophysics Data System (ADS)

    Margitus, Michael R.; Tagliaferri, William A., Jr.; Sudit, Moises; LaMonica, Peter M.

    2012-06-01

    Understanding the structure and dynamics of networks are of vital importance to winning the global war on terror. To fully comprehend the network environment, analysts must be able to investigate interconnected relationships of many diverse network types simultaneously as they evolve both spatially and temporally. To remove the burden from the analyst of making mental correlations of observations and conclusions from multiple domains, we introduce the Dynamic Graph Analytic Framework (DYGRAF). DYGRAF provides the infrastructure which facilitates a layered multi-modal network analysis (LMMNA) approach that enables analysts to assemble previously disconnected, yet related, networks in a common battle space picture. In doing so, DYGRAF provides the analyst with timely situation awareness, understanding and anticipation of threats, and support for effective decision-making in diverse environments.

  11. 2D analysis of polydisperse core-shell nanoparticles using analytical ultracentrifugation.

    PubMed

    Walter, Johannes; Gorbet, Gary; Akdas, Tugce; Segets, Doris; Demeler, Borries; Peukert, Wolfgang

    2016-12-19

    Accurate knowledge of the size, density and composition of nanoparticles (NPs) is of major importance for their applications. In this work the hydrodynamic characterization of polydisperse core-shell NPs by means of analytical ultracentrifugation (AUC) is addressed. AUC is one of the most accurate techniques for the characterization of NPs in the liquid phase because it can resolve particle size distributions (PSDs) with unrivaled resolution and detail. Small NPs have to be considered as core-shell systems when dispersed in a liquid since a solvation layer and a stabilizer shell will significantly contribute to the particle's hydrodynamic diameter and effective density. AUC measures the sedimentation and diffusion transport of the analytes, which are affected by the core-shell compositional properties. This work demonstrates that polydisperse and thus widely distributed NPs pose significant challenges for current state-of-the-art data evaluation methods. The existing methods either have insufficient resolution or do not correctly reproduce the core-shell properties. First, we investigate the performance of different data evaluation models by means of simulated data. Then, we propose a new methodology to address the core-shell properties of NPs. This method is based on the parametrically constrained spectrum analysis and offers complete access to the size and effective density of polydisperse NPs. Our study is complemented using experimental data derived for ZnO and CuInS2 NPs, which do not have a monodisperse PSD. For the first time, the size and effective density of such structures could be resolved with high resolution by means of a two-dimensional AUC analysis approach.

  12. Non invasive analysis of miniature paintings: Proposal for an analytical protocol

    NASA Astrophysics Data System (ADS)

    Aceto, Maurizio; Agostino, Angelo; Fenoglio, Gaia; Gulmini, Monica; Bianco, Valentina; Pellizzi, Eleonora

    2012-06-01

    The characterisation of palettes used in manuscript illumination is a hard analytical task, due to value and fragility of the analysed items. Analysis on miniatures must be necessarily non-invasive and fast and requires the use of several techniques since no single technique is able to provide all information needed. In this work a four-step analytical protocol is proposed for non-invasive in situ characterisation of miniature paintings. The protocol allows the identification of coloured materials through the use in sequence of complementary techniques, so as to fully exploit the information given by each instrument. Preliminarily to the instrumental investigations on ancient books and miniatures is the compilation of spectroscopic databases obtained from "standard" samples prepared on parchment, according to recipes described in medieval artistic treatises. The protocol starts with an extensive investigation with UV-visible spectrophotometry in reflectance mode, collecting spectra from all the most significant painted areas in the manuscript; chemometric classification is then performed on the spectra to highlight areas possibly containing the same materials. The second step involves in-depth inspection of miniatures under optical microscopy that guides the interpretation of reflectance spectra. XRF spectrometry is then performed to characterise pigments and metal layers, to verify the presence of overlapping layers, to identify mordants in lakes and to recognise minor components that may yield information concerning provenance; in addition, chemometric classification can be performed on element concentrations to highlight similar areas. Finally, Raman spectroscopy is used to shed light on the uncertain cases, if still present. Such a procedure offers a wealth of information without causing stress to the manuscripts under analysis.

  13. Should patients receive secondary prevention medications for free after a myocardial infarction? An economic analysis.

    PubMed

    Choudhry, Niteesh K; Avorn, Jerry; Antman, Elliott M; Schneeweiss, Sebastian; Shrank, William H

    2007-01-01

    Taken in combination, aspirin, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, and statins (combination pharmacotherapy) greatly reduce cardiac events. These therapies are underused, even among patients with drug insurance. Out-of-pocket spending is a key barrier to adherence. We estimated the impact of providing combination pharmacotherapy without cost sharing ("full coverage") to insured patients after a myocardial infarction (MI). Under base-case assumptions, compared to standard coverage, three years of full coverage will reduce mortality and reinfarction rates and will save 5,974 per patient. Our analysis suggests that covering combination therapy for such patients will save both lives and money.

  14. Development of Soil Compaction Analysis Software (SCAN) Integrating a Low Cost GPS Receiver and Compactometer

    PubMed Central

    Hwang, Jinsang; Yun, Hongsik; Kim, Juhyong; Suh, Yongcheol; Hong, Sungnam; Lee, Dongha

    2012-01-01

    A software for soil compaction analysis (SCAN) has been developed for evaluating the compaction states using the data from the GPS as well as a compactometer attached on the roller. The SCAN is distinguished from other previous software for intelligent compaction (IC) in that it can use the results from various types of GPS positioning methods, and it also has an optimal structure for remotely managing the large amounts of data gathered from numerous rollers. For this, several methods were developed: (1) improving the accuracy of low cost GPS receiver’s positioning results; (2) modeling the trajectory of a moving roller using a GPS receiver’s results and linking it with the data from the compactometer; and (3) extracting the information regarding the compaction states of the ground from the modeled trajectory, using spatial analysis methods. The SCAN was verified throughout various field compaction tests, and it has been confirmed that it can be a very effective tool in evaluating field compaction states. PMID:22736955

  15. The Analytic Onion: Examining Training Issues from Different Levels of Analysis. Interim Technical Paper for Period July 1989-June 1991.

    ERIC Educational Resources Information Center

    Lamb, Theodore A.; Chin, Keric B. O.

    This paper proposes a conceptual framework based on different levels of analysis using the metaphor of the layers of an onion to help organize and structure thinking on research issues concerning training. It discusses the core of the "analytic onion," the biological level, and seven levels of analysis that surround that core: the individual, the…

  16. Familiarity Vs Trust: A Comparative Study of Domain Scientists' Trust in Visual Analytics and Conventional Analysis Methods.

    PubMed

    Dasgupta, Aritra; Lee, Joon-Yong; Wilson, Ryan; Lafrance, Robert A; Cramer, Nick; Cook, Kristin; Payne, Samuel

    2017-01-01

    Combining interactive visualization with automated analytical methods like statistics and data mining facilitates data-driven discovery. These visual analytic methods are beginning to be instantiated within mixed-initiative systems, where humans and machines collaboratively influence evidence-gathering and decision-making. But an open research question is that, when domain experts analyze their data, can they completely trust the outputs and operations on the machine-side? Visualization potentially leads to a transparent analysis process, but do domain experts always trust what they see? To address these questions, we present results from the design and evaluation of a mixed-initiative, visual analytics system for biologists, focusing on analyzing the relationships between familiarity of an analysis medium and domain experts' trust. We propose a trust-augmented design of the visual analytics system, that explicitly takes into account domain-specific tasks, conventions, and preferences. For evaluating the system, we present the results of a controlled user study with 34 biologists where we compare the variation of the level of trust across conventional and visual analytic mediums and explore the influence of familiarity and task complexity on trust. We find that despite being unfamiliar with a visual analytic medium, scientists seem to have an average level of trust that is comparable with the same in conventional analysis medium. In fact, for complex sense-making tasks, we find that the visual analytic system is able to inspire greater trust than other mediums. We summarize the implications of our findings with directions for future research on trustworthiness of visual analytic systems.

  17. Development of a geovisual analytics environment using parallel coordinates with applications to tropical cyclone trend analysis

    NASA Astrophysics Data System (ADS)

    Steed, Chad Allen

    A global transformation is being fueled by unprecedented growth in the quality, quantity, and number of different parameters in environmental data through the convergence of several technological advances in data collection and modeling. Although these data hold great potential for helping us understand many complex and, in some cases, life-threatening environmental processes, our ability to generate such data is far outpacing our ability to analyze it. In particular, conventional environmental data analysis tools are inadequate for coping with the size and complexity of these data. As a result, users are forced to reduce the problem in order to adapt to the capabilities of the tools. To overcome these limitations, we must complement the power of computational methods with human knowledge, flexible thinking, imagination, and our capacity for insight by developing visual analysis tools that distill information into the actionable criteria needed for enhanced decision support. In light of said challenges, we have integrated automated statistical analysis capabilities with a highly interactive, multivariate visualization interface to produce a promising approach for visual environmental data analysis. By combining advanced interaction techniques such as dynamic axis scaling, conjunctive parallel coordinates, statistical indicators, and aerial perspective shading, we provide an enhanced variant of the classical parallel coordinates plot. Furthermore, the system facilitates statistical processes such as stepwise linear regression and correlation analysis to assist in the identification and quantification of the most significant predictors for a particular dependent variable. These capabilities are combined into a unique geovisual analytics system that is demonstrated via a pedagogical case study and three North Atlantic tropical cyclone climate studies using a systematic workflow. In addition to revealing several significant associations between environmental

  18. Depth of the main crustal and mantle interfaces beneath the Gorely volcano (Kamchatka) based on the receiver function analysis

    NASA Astrophysics Data System (ADS)

    Ivanov, Arseny; Woelbern, Ingo; Nikulin, Alex; Koulakov, Ivan; Jakovlev, Andrey; Gordeev, Evgeny; Abkadyrov, Ilyas

    2016-04-01

    Gorely volcano is located in the southern part of the Kamchatka peninsula. It is two-tier structure with an old shield volcano at the base and a younger edifice on the top. The subducting Pacific oceanic Plate is located at the depth of 120 km beneath the volcano. The receiver function method was used to investigate the 1D structure beneath the volcano. From the continuous yearly seismograms recorded by a temporary network consisting of 16 seismic stations, we selected more than 600 records corresponding to teleseismic events which were used for the receiver function analysis. Based on the method by Zhu and Kanamory, we have determined the depth of the Moho interface at 38 km and that of the Conrad discontinuity at 26 km. These values correspond to the well exposed continental crust. The receiver functions also provide a rather prominent signal corresponding to a discontinuity at ~300 km depth; however, no clear signatures of deeper interfaces and slab interfaces are determined in this study. This study is the first attempt to determine the depth of the major interfaces beneath the Gorely volcano.

  19. Comparison of three prospective analytical methods for benzene analysis in jet-fuel environments. Final report

    SciTech Connect

    Hossain, M.A.

    1990-08-01

    Accurate analysis of benzene in jet fuel has been a concern over the past several years. The method we have been using to analyze benzene in jet fuel is the NIOSH 1501 method, a method specifically designed for aromatic hydrocarbons including benzene. However, the method is not designed for analysis of benzene in jet fuel environments. At the present time there is no approved (either by NIOSH or OSHA) method for analysis of benzene in fuel environments. At the request of HQ AAC/SGPB, we recently conducted a study to compare three prospective analytical methods (NIOSH method 1501 (GC/FID wtih packed column) modified NIOSH 1501 method (GC/FID with capillary column), and High Pressure Liquid Chromatography with Ultraviolet Detection (HPLC/UV)). In this study spiked charcoal tube samples as well as air samples of known concentrations of benzene in JP-4 and Stoddard Solvents were analyzed by all three methods. The test results showed that modified NIOSH 1501 and HPLC methods had good correlation between spiked and measured amount of benzene in JP-4 and Stoddard Solvent mixtures. The NIOSH 1501 method utilizing packed column over estimated the test benzene concentration indicating positive interference from other hydrocarbons present in JP 4 and Stoddard Solvents.

  20. Improved gas chromatography-flame ionization detector analytical method for the analysis of epoxy fatty acids.

    PubMed

    Mubiru, Edward; Shrestha, Kshitij; Papastergiadis, Antonios; De Meulenaer, Bruno

    2013-11-29

    In this study an improved method for analysis of epoxy fatty acids is reported. Data obtained from analysis of polar fatty acids has previously been presented, but due to the high number of compounds that co-elute in the polar fraction, the resultant chromatograms are complex which may lead to compromising the accuracy of the data. A three steps separation of fatty acid methyl esters (FAMEs) by solid-phase extraction (SPE) on a silica gel column to remove hydroxy fatty acid interferences was proposed. This approach is opposed to a two step separation procedure that has been often used to prevent analytical interferences caused by non-altered fatty acids. A gas chromatograph with a flame ionization detector (GC-FID) equipped with a polar CP-Sil 88™ column was used. Quantification was based on the use of methyl nonadecanoate (C19:0), as an internal standard. Individual mono epoxy fatty acids were well separated without co-eluting compounds. The optimized method was finally applied to screen epoxy fatty acids in 37 fresh oil samples. Results obtained for the total epoxy fatty acids were in the range 0.03-2mgg(-1) of oil with repeatability coefficient of variation (CV) ranging from 2.8 to 9.9% for duplicate analysis showing that the results obtained are repeatable.

  1. Analysis of the Uncertainty in the Computation of Receiver Functions and Improvement in the Estimation of Receiver, PP and SS functions

    NASA Astrophysics Data System (ADS)

    Huang, X.; Gurrola, H.

    2013-12-01

    There are many methods used to produce receiver functions (RFs) that are referred to as deconvolution but some are based on cross-correlation methods. We produced a set of realistic synthetics to test four commonly used methods to produce RFs. These are the frequency domain 'water level deconvolution (FWLD), the time domain iterative deconvolution (TID), the least square matrix inversion (MID) and the log-spectral method of deconvolution (LSD). We also test a hybrid of the FWLD and TID methods that we refer to as the frequency domain iterative deconvolution (FID). Synthetics were produced by windowing a P recordings from real seismograms and convolving them with synthetic seismograms, and then adding samples of pre-event noise. We made synthetics with nose levels of 2, 4, 8 and 16 percent [defined as stdev(noise)/max(signal)]. For the synthetics all methods of receiver function were accurate in estimating arrival times of the P, Ps, PPs and PSs phase to within one sample (at 40 sps). But there was a strong bias toward low values in the estimation of amplitudes of these phases (even when compared as ratios, i.e. Ps/P). The larger the noise levels the larger the bias. For 2% noise all methods preformed well. As noise increased there was a wide range in bias. The LSD and FID method produced the smallest standard deviation (stdev) of the group in bootstrap estimates from 92 different synthetic. If these RFs were from real data, where we did not know the right answers, LSD and FID would have been considered to work equally well. However, knowing the correct answer, the LSD methods had tremendous bias toward underestimating the amplitude especially for smaller phases. In tests using real data from Arti, Russia (ARU), we found that all these methods preformed equally well in estimating the arrival times for larger phases (such as Pms) but for smaller phases (such as P410s) the FID and TID had half as much error in estimating the arrival times as compared to the other

  2. Analysis of Local Control in Patients Receiving IMRT for Resected Pancreatic Cancers

    SciTech Connect

    Yovino, Susannah; Maidment, Bert W.; Herman, Joseph M.; Pandya, Naimish; Goloubeva, Olga; Wolfgang, Chris; Schulick, Richard; Laheru, Daniel; Hanna, Nader; Alexander, Richard; Regine, William F.

    2012-07-01

    Purpose: Intensity-modulated radiotherapy (IMRT) is increasingly incorporated into therapy for pancreatic cancer. A concern regarding this technique is the potential for geographic miss and decreased local control. We analyzed patterns of first failure among patients treated with IMRT for resected pancreatic cancer. Methods and Materials: Seventy-one patients who underwent resection and adjuvant chemoradiation for pancreas cancer are included in this report. IMRT was used for all to a median dose of 50.4 Gy. Concurrent chemotherapy was 5-FU-based in 72% of patients and gemcitabine-based in 28%. Results: At median follow-up of 24 months, 49/71 patients (69%) had failed. The predominant failure pattern was distant metastases in 35/71 patients (49%). The most common site of metastases was the liver. Fourteen patients (19%) developed locoregional failure in the tumor bed alone in 5 patients, regional nodes in 4 patients, and concurrently with metastases in 5 patients. Median overall survival (OS) was 25 months. On univariate analysis, nodal status, margin status, postoperative CA 19-9 level, and weight loss during treatment were predictive for OS. On multivariate analysis, higher postoperative CA19-9 levels predicted for worse OS on a continuous basis (p < 0.01). A trend to worse OS was seen among patients with more weight loss during therapy (p = 0.06). Patients with positive nodes and positive margins also had significantly worse OS (HR for death 2.8, 95% CI 1.1-7.5; HR for death 2.6, 95% CI 1.1-6.2, respectively). Grade 3-4 nausea and vomiting was seen in 8% of patients. Late complication of small bowel obstruction occurred in 4 (6%) patients. Conclusions: This is the first comprehensive report of patterns of failure among patients treated with adjuvant IMRT for pancreas cancer. IMRT was not associated with an increase in local recurrences in our cohort. These data support the use of IMRT in the recently activated EORTC/US Intergroup/RTOG 0848 adjuvant pancreas

  3. CALUTRON RECEIVER

    DOEpatents

    Barnes, S.W.

    1959-08-25

    An improvement in a calutron receiver for collecting the isotopes ts described. The electromagnetic separation of the isotopes produces a mass spectrum of closely adjacent beams of ions at the foci regions, and a dividing wall between the two pockets is arranged at an angle. Substantially all of the tons of the less abundant isotope enter one of the pockets and strike one side of the wall directly, while substantially none of the tons entering the other pocket strikes the wall directly.

  4. Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a

    PubMed Central

    Quintás-Cardama, Alfonso; Abdel-Wahab, Omar; Manshouri, Taghi; Kilpivaara, Outi; Cortes, Jorge; Roupie, Anne-Laure; Zhang, Su-Jiang; Harris, David; Estrov, Zeev; Kantarjian, Hagop

    2013-01-01

    Pegylated interferon α-2a (PEG-IFN-α-2a) has previously been shown to induce hematologic and molecular responses in patients with polycythemia vera (PV) or essential thrombocythemia (ET). Here we present a follow-up of a phase 2 trial with PEG-IFN-α-2a treatment in 43 PV and 40 ET patients with detailed molecular analysis. After a median follow-up of 42 months, complete hematologic response was achieved in 76% of patients with PV and 77% of those with ET. This was accompanied by complete molecular response (CMR) (ie, undetectable JAK2V617F) in 18% and 17%, of PV and ET patients, respectively. Serial sequencing of TET2, ASXL1, EZH2, DNMT3A, and IDH1/2 revealed that patients failing to achieve CMR had a higher frequency of mutations outside the Janus kinase–signal transducer and activator of transcription pathway and were more likely to acquire new mutations during therapy. Patients with both JAK2V617F and TET2 mutations at therapy onset had a higher JAK2V617F mutant allele burden and a less significant reduction in JAK2V617F allele burden compared with JAK2 mutant/TET2 wild-type patients. These data demonstrate that PEG-IFN-α-2a induces sustained CMR in a subset of PV or ET patients, and that genotypic context may influence clinical and molecular response to PEG-IFN-α-2a. PMID:23782935

  5. Morphological analysis of the primary center receiving spatial information transferred by the waggle dance of honeybees.

    PubMed

    Ai, Hiroyuki; Hagio, Hiromi

    2013-08-01

    The waggle dancers of honeybees encodes roughly the distance and direction to the food source as the duration of the waggle phase and the body angle during the waggle phase. It is believed that hive-mates detect airborne vibrations produced during the waggle phase to acquire distance information and simultaneously detect the body axis during the waggle phase to acquire direction information. It has been further proposed that the orientation of the body axis on the vertical comb is detected by neck hairs (NHs) on the prosternal organ. The afferents of the NHs project into the prothoracic and mesothoracic ganglia and the dorsal subesophageal ganglion (dSEG). This study demonstrates somatotopic organization within the dSEG of the central projections of the mechanosensory neurons of the NHs. The terminals of the NH afferents in dSEG are in close apposition to those of Johnston's organ (JO) afferents. The sensory axons of both terminate in a region posterior to the crossing of the ventral intermediate tract (VIT) and the maxillary dorsal commissures I and III (MxDCI, III) in the subesophageal ganglion. These features of the terminal areas of the NH and JO afferents are common to the worker, drone, and queen castes of honeybees. Analysis of the spatial relationship between the NH neurons and the morphologically and physiologically characterized vibration-sensitive interneurons DL-Int-1 and DL-Int-2 demonstrated that several branches of DL-Int-1 are in close proximity to the central projection of the mechanosensory neurons of the NHs in the dSEG.

  6. Analytical Aspects of EPMA for Trace Element Analysis in Complex Accessory Minerals

    NASA Astrophysics Data System (ADS)

    Jercinovic, M. J.; Williams, M. L.; Lane, E.

    2007-12-01

    High-resolution microanalysis of complex REE-bearing accessory phases is becoming increasingly necessary for insight into the chronology of phase growth and tectonic histories, and in understanding the mechanisms and manifestations of growth and dissolution reactions. The in-situ analysis of very small grains, inclusions, and sub-domains is revolutionizing our understanding of the evolution of complexly deformed, multiply metamorphosed, rocks. Great progress has been made in refining analytical protocols, and improvements in instrumentation have yielded unprecedented analytical precision and spatial resolution. As signal/noise improves, complexity is revealed, illustrating the level of care that must go into obtaining meaningful results, and in adopting an appropriate approach to minimize error. Background measurement is most critical for low concentration elements. Errors on net intensity values resulting from improper background measurement alone can exceed 50% relative. Regression and modeling of the background spectrum is essential, and must be carried out independently for each spectrometer, regardless of instrument. In complex materials such as REE- bearing phosphates, high concentrations of REEs and actinides create difficult analytical challenges as numerous emission lines and absorption edges cause great spectral complexity. In addition, trace concentrations of "unexpected" emission lines such as those from sulfur, or fluoresced from nearby phases (Ti, K), cause interferences on both measured peaks and background regions which can result in very large errors on target elements (U, Pb, etc.), on the order of 10s to 100s of ppm. Characteristic X-ray emission involving electron transitions from the valence shell are subject to measureable peak shifts, in some cases significantly affecting the accuracy of results if not accounted for. Geochronology by EPMA involves careful measurement of all constituent elements, with the calculated date dependant on the

  7. Analysis of structural dynamic data from Skylab. Volume 2: Skylab analytical and test modal data

    NASA Technical Reports Server (NTRS)

    Demchak, L.; Harcrow, H.

    1976-01-01

    A compendium is presented of orbital configuration test modal data, analytical test modal data, analytical test correlation modal data and analytical flight configuration 1.2 modal data. Section A presents tables showing the generalized mass contributions for each of the thirty test modes. Section B presents the two dimensional mode shape plots for the thirty test modes. Tables of GMC's for the test correlated analytical modes are presented in Section C. These analytical modes were generated from a model that was adjusted to match test results by use of the methodology discussed in Sections 2.3 and 5.4 of Volume I of this report. Section D presents the two dimensional mode shape plots for the analytical modes. Sections E and F contain the uncoupled and coupled modes of the orbital flight configuration 1.2 at three development phases of the model.

  8. Elastoplastic buckling analysis of cylindrical shells using a semi-analytical formulation

    NASA Astrophysics Data System (ADS)

    Deerenberg, E.

    1994-10-01

    In this thesis, a semi-analytical formulation for the buckling analysis of circular cylindrical shells is described that takes into account the combined effects of initial geometric imperfections, elastoplastic material behavior and boundary conditions. The model is based on small strains-moderate rotations shell theory. The governing equations are formulated as a coupled set of first-order ordinary differential and algebraic equations. The basic variables in these equations are the variables that can be prescribed at the shell edges. The model described in this thesis is valid for cylinders with a multi-layer wall construction that may be loaded by axial compression, external pressure and/or torsion. The governing differential/algebraic equations are solved using Newton-type iteration methods. Separate equations are formulated for the bifurcation analysis of axisymmetric prebuckling states and an efficient solution method for the eigenvalue problem is described. The correctness of the formulation is checked by analyzing a number of elastic and elastoplastic buckling problems of perfect and imperfect shells.

  9. Selection of infectious medical waste disposal firms by using the analytic hierarchy process and sensitivity analysis

    SciTech Connect

    Hsu, P.-F. Wu, C.-R. Li, Y.-T.

    2008-07-01

    While Taiwanese hospitals dispose of large amounts of medical waste to ensure sanitation and personal hygiene, doing so inefficiently creates potential environmental hazards and increases operational expenses. However, hospitals lack objective criteria to select the most appropriate waste disposal firm and evaluate its performance, instead relying on their own subjective judgment and previous experiences. Therefore, this work presents an analytic hierarchy process (AHP) method to objectively select medical waste disposal firms based on the results of interviews with experts in the field, thus reducing overhead costs and enhancing medical waste management. An appropriate weight criterion based on AHP is derived to assess the effectiveness of medical waste disposal firms. The proposed AHP-based method offers a more efficient and precise means of selecting medical waste firms than subjective assessment methods do, thus reducing the potential risks for hospitals. Analysis results indicate that the medical sector selects the most appropriate infectious medical waste disposal firm based on the following rank: matching degree, contractor's qualifications, contractor's service capability, contractor's equipment and economic factors. By providing hospitals with an effective means of evaluating medical waste disposal firms, the proposed AHP method can reduce overhead costs and enable medical waste management to understand the market demand in the health sector. Moreover, performed through use of Expert Choice software, sensitivity analysis can survey the criterion weight of the degree of influence with an alternative hierarchy.

  10. Measuring the Grafting Density of Nanoparticles in Solution by Analytical Ultracentrifugation and Total Organic Carbon Analysis

    PubMed Central

    Benoit, Denise N.; Zhu, Huiguang; Lilierose, Michael H.; Verm, Raymond A.; Ali, Naushaba; Morrison, Adam N.; Fortner, John D.; Avendano, Carolina; Colvin, Vicki L.

    2012-01-01

    Many of the solution phase properties of nanoparticles, such as their colloidal stability and hydrodynamic diameter, are governed by the number of stabilizing groups bound to the particle surface (i.e., grafting density). Here we show how two techniques, analytical ultracentrifugation (AUC) and total organic carbon analysis (TOC), can be applied separately to the measurement of this parameter. AUC directly measures the density of nanoparticle–polymer conjugates while TOC provides the total carbon content of its aqueous dispersions. When these techniques are applied to model gold nanoparticles capped with thiolated poly(ethylene glycol), the measured grafting densities across a range of polymer chain lengths, polymer concentrations, and nanoparticle diameters agree to within 20%. Moreover, the measured grafting densities correlate well with the polymer content determined by thermogravimetric analysis of solid conjugate samples. Using these tools, we examine the particle core diameter, polymer chain length, and polymer solution concentration dependence of nanoparticle grafting densities in a gold nanoparticle–poly(ethylene glycol) conjugate system. PMID:22967239

  11. Analytical determination of flavonoids aimed to analysis of natural samples and active packaging applications.

    PubMed

    Castro-López, María del Mar; López-Vilariño, José Manuel; González-Rodríguez, María Victoria

    2014-05-01

    Several HPLC and UHPLC developed methods were compared to analyse the natural antioxidants catechins and quercetin used in active packaging and functional foods. Photodiode array detector coupled with a fluorescence detector and compared with LTQ-Orbitrap-MS was used. UHPLC was investigated as quick alternative without compromising the separation, analysis time shortened up to 6-fold. The feasibility of the four developed methods was compared. Linearity up to 0.9995, low detection limits (between 0.02 and 0.7 for HPLC-PDA, 2 to 7-fold lower for HPLC- LTQ-Orbitrap-MS and from 0.2 to 2mgL(-)(1) for UHPLC-PDA) and good precision parameters (RSD lower than 0.06%) were obtained. All methods were successfully applied to natural samples. LTQ-Orbitrap-MS allowed to identify other analytes of interest too. Good feasibility of the methods was also concluded from the analysis of catechin and quercetin release from new active packaging materials based on polypropylene added with catechins and green tea.

  12. Fabricating Cotton Analytical Devices.

    PubMed

    Lin, Shang-Chi; Hsu, Min-Yen; Kuan, Chen-Meng; Tseng, Fan-Gang; Cheng, Chao-Min

    2016-08-30

    A robust, low-cost analytical device should be user-friendly, rapid, and affordable. Such devices should also be able to operate with scarce samples and provide information for follow-up treatment. Here, we demonstrate the development of a cotton-based urinalysis (i.e., nitrite, total protein, and urobilinogen assays) analytical device that employs a lateral flow-based format, and is inexpensive, easily fabricated, rapid, and can be used to conduct multiple tests without cross-contamination worries. Cotton is composed of cellulose fibers with natural absorptive properties that can be leveraged for flow-based analysis. The simple but elegant fabrication process of our cotton-based analytical device is described in this study. The arrangement of the cotton structure and test pad takes advantage of the hydrophobicity and absorptive strength of each material. Because of these physical characteristics, colorimetric results can persistently adhere to the test pad. This device enables physicians to receive clinical information in a timely manner and shows great potential as a tool for early intervention.

  13. An Analytical Model for the Performance Analysis of Concurrent Transmission in IEEE 802.15.4

    PubMed Central

    Gezer, Cengiz; Zanella, Alberto; Verdone, Roberto

    2014-01-01

    Interference is a serious cause of performance degradation for IEEE802.15.4 devices. The effect of concurrent transmissions in IEEE 802.15.4 has been generally investigated by means of simulation or experimental activities. In this paper, a mathematical framework for the derivation of chip, symbol and packet error probability of a typical IEEE 802.15.4 receiver in the presence of interference is proposed. Both non-coherent and coherent demodulation schemes are considered by our model under the assumption of the absence of thermal noise. Simulation results are also added to assess the validity of the mathematical framework when the effect of thermal noise cannot be neglected. Numerical results show that the proposed analysis is in agreement with the measurement results on the literature under realistic working conditions. PMID:24658624

  14. An analytical model for the performance analysis of concurrent transmission in IEEE 802.15.4.

    PubMed

    Gezer, Cengiz; Zanella, Alberto; Verdone, Roberto

    2014-03-20

    Interference is a serious cause of performance degradation for IEEE802.15.4 devices. The effect of concurrent transmissions in IEEE 802.15.4 has been generally investigated by means of simulation or experimental activities. In this paper, a mathematical framework for the derivation of chip, symbol and packet error probability of a typical IEEE 802.15.4 receiver in the presence of interference is proposed. Both non-coherent and coherent demodulation schemes are considered by our model under the assumption of the absence of thermal noise. Simulation results are also added to assess the validity of the mathematical framework when the effect of thermal noise cannot be neglected. Numerical results show that the proposed analysis is in agreement with the measurement results on the literature under realistic working conditions.

  15. Should all anticoagulated patients with head injury receive a CT scan? Decision-analysis modelling of an observational cohort

    PubMed Central

    Kuczawski, Maxine; Stevenson, Matt; Goodacre, Steve; Teare, M Dawn; Ramlakhan, Shammi; Morris, Francis; Mason, Suzanne

    2016-01-01

    Objectives It is not currently clear whether all anticoagulated patients with a head injury should receive CT scanning or only those with evidence of traumatic brain injury (eg, loss of consciousness or amnesia). We aimed to determine the cost-effectiveness of CT for all compared with selective CT use for anticoagulated patients with a head injury. Design Decision-analysis modelling of data from a multicentre observational study. Setting 33 emergency departments in England and Scotland. Participants 3566 adults (aged ≥16 years) who had suffered blunt head injury, were taking warfarin and underwent selective CT scanning. Main outcome measures Estimated expected benefits in terms of quality-adjusted life years (QALYs) were the entire cohort to receive a CT scan; estimated increased costs of CT and also the potential cost implications associated with patient survival and improved health. These values were used to estimate the cost per QALY of implementing a strategy of CT for all patients compared with observed practice based on guidelines recommending selective CT use. Results Of the 1420 of 3534 patients (40%) who did not receive a CT scan, 7 (0.5%) suffered a potentially avoidable head injury-related adverse outcome. If CT scanning had been performed in all patients, appropriate treatment could have gained 3.41 additional QALYs but would have incurred £193 149 additional treatment costs and £130 683 additional CT costs. The incremental cost-effectiveness ratio of £94 895/QALY gained for unselective compared with selective CT use is markedly above the threshold of £20–30 000/QALY used by the UK National Institute for Care Excellence to determine cost-effectiveness. Conclusions CT scanning for all anticoagulated patients with head injury is not cost-effective compared with selective use of CT scanning based on guidelines recommending scanning only for those with evidence of traumatic brain injury. Trial registration number NCT 02461498. PMID

  16. The Challenge of Understanding Process in Clinical Behavior Analysis: The Case of Functional Analytic Psychotherapy

    ERIC Educational Resources Information Center

    Follette, William C.; Bonow, Jordan T.

    2009-01-01

    Whether explicitly acknowledged or not, behavior-analytic principles are at the heart of most, if not all, empirically supported therapies. However, the change process in psychotherapy is only now being rigorously studied. Functional analytic psychotherapy (FAP; Kohlenberg & Tsai, 1991; Tsai et al., 2009) explicitly identifies behavioral-change…

  17. The Promise and Peril of Predictive Analytics in Higher Education: A Landscape Analysis

    ERIC Educational Resources Information Center

    Ekowo, Manuela; Palmer, Iris

    2016-01-01

    Predictive analytics in higher education is a hot-button topic among educators and administrators as institutions strive to better serve students by becoming more data-informed. In this paper, the authors describe how predictive analytics are used in higher education to identify students who need extra support, steer students in courses they will…

  18. Receiver Analysis Program

    DTIC Science & Technology

    1976-12-01

    ITHIW D^EF HDTE:l..iFITE 99 FDP LnMCMM IMTFFCEPT p^UErSS^f ^^T,: FEFEF TC IMFUT LEVEL. BSSIrSf.JtSS ’s^𔃿 ""^ ^LIFIEP, MIXER... FEFEF : TD MIT ÜF FF INPUT FPEQUENCY MIT DF F:F INPUT FPEOUEMCY ILLftTDP FPEOUEhCY MIT DP IF IMPUT FPEOUEHCY MIT DF IF

  19. The Role of Teamwork in the Analysis of Big Data: A Study of Visual Analytics and Box Office Prediction.

    PubMed

    Buchanan, Verica; Lu, Yafeng; McNeese, Nathan; Steptoe, Michael; Maciejewski, Ross; Cooke, Nancy

    2017-03-01

    Historically, domains such as business intelligence would require a single analyst to engage with data, develop a model, answer operational questions, and predict future behaviors. However, as the problems and domains become more complex, organizations are employing teams of analysts to explore and model data to generate knowledge. Furthermore, given the rapid increase in data collection, organizations are struggling to develop practices for intelligence analysis in the era of big data. Currently, a variety of machine learning and data mining techniques are available to model data and to generate insights and predictions, and developments in the field of visual analytics have focused on how to effectively link data mining algorithms with interactive visuals to enable analysts to explore, understand, and interact with data and data models. Although studies have explored the role of single analysts in the visual analytics pipeline, little work has explored the role of teamwork and visual analytics in the analysis of big data. In this article, we present an experiment integrating statistical models, visual analytics techniques, and user experiments to study the role of teamwork in predictive analytics. We frame our experiment around the analysis of social media data for box office prediction problems and compare the prediction performance of teams, groups, and individuals. Our results indicate that a team's performance is mediated by the team's characteristics such as openness of individual members to others' positions and the type of planning that goes into the team's analysis. These findings have important implications for how organizations should create teams in order to make effective use of information from their analytic models.

  20. Trace analysis of energetic materials via direct analyte-probed nanoextraction coupled to direct analysis in real time mass spectrometry.

    PubMed

    Clemons, Kristina; Dake, Jeffrey; Sisco, Edward; Verbeck, Guido F

    2013-09-10

    Direct analysis in real time mass spectrometry (DART-MS) has proven to be a useful forensic tool for the trace analysis of energetic materials. While other techniques for detecting trace amounts of explosives involve extraction, derivatization, solvent exchange, or sample clean-up, DART-MS requires none of these. Typical DART-MS analyses directly from a solid sample or from a swab have been quite successful; however, these methods may not always be an optimal sampling technique in a forensic setting. For example, if the sample were only located in an area which included a latent fingerprint of interest, direct DART-MS analysis or the use of a swab would almost certainly destroy the print. To avoid ruining such potentially invaluable evidence, another method has been developed which will leave the fingerprint virtually untouched. Direct analyte-probed nanoextraction coupled to nanospray ionization-mass spectrometry (DAPNe-NSI-MS) has demonstrated excellent sensitivity and repeatability in forensic analyses of trace amounts of illicit drugs from various types of surfaces. This technique employs a nanomanipulator in conjunction with bright-field microscopy to extract single particles from a surface of interest and has provided a limit of detection of 300 attograms for caffeine. Combining DAPNe with DART-MS provides another level of flexibility in forensic analysis, and has proven to be a sufficient detection method for trinitrotoluene (TNT), RDX, and 1-methylaminoanthraquinone (MAAQ).

  1. Evidence for the contemporary magmatic system beneath Long Valley Caldera from local earthquake tomography and receiver function analysis

    USGS Publications Warehouse

    Seccia, D.; Chiarabba, C.; De Gori, P.; Bianchi, I.; Hill, D.P.

    2011-01-01

    We present a new P wave and S wave velocity model for the upper crust beneath Long Valley Caldera obtained using local earthquake tomography and receiver function analysis. We computed the tomographic model using both a graded inversion scheme and a traditional approach. We complement the tomographic I/P model with a teleseismic receiver function model based on data from broadband seismic stations (MLAC and MKV) located on the SE and SW margins of the resurgent dome inside the caldera. The inversions resolve (1) a shallow, high-velocity P wave anomaly associated with the structural uplift of a resurgent dome; (2) an elongated, WNW striking low-velocity anomaly (8%–10 % reduction in I/P) at a depth of 6 km (4 km below mean sea level) beneath the southern section of the resurgent dome; and (3) a broad, low-velocity volume (–5% reduction in I/P and as much as 40% reduction in I/S) in the depth interval 8–14 km (6–12 km below mean sea level) beneath the central section of the caldera. The two low-velocity volumes partially overlap the geodetically inferred inflation sources that drove uplift of the resurgent dome associated with caldera unrest between 1980 and 2000, and they likely reflect the ascent path for magma or magmatic fluids into the upper crust beneath the caldera.

  2. Evidence for the contemporary magmatic system beneath Long Valley Caldera from local earthquake tomography and receiver function analysis

    NASA Astrophysics Data System (ADS)

    Seccia, D.; Chiarabba, C.; de Gori, P.; Bianchi, I.; Hill, D. P.

    2011-12-01

    We present a new P wave and S wave velocity model for the upper crust beneath Long Valley Caldera obtained using local earthquake tomography and receiver function analysis. We computed the tomographic model using both a graded inversion scheme and a traditional approach. We complement the tomographic Vp model with a teleseismic receiver function model based on data from broadband seismic stations (MLAC and MKV) located on the SE and SW margins of the resurgent dome inside the caldera. The inversions resolve (1) a shallow, high-velocity P wave anomaly associated with the structural uplift of a resurgent dome; (2) an elongated, WNW striking low-velocity anomaly (8%-10 % reduction in Vp) at a depth of 6 km (4 km below mean sea level) beneath the southern section of the resurgent dome; and (3) a broad, low-velocity volume (˜5% reduction in Vp and as much as 40% reduction in Vs) in the depth interval 8-14 km (6-12 km below mean sea level) beneath the central section of the caldera. The two low-velocity volumes partially overlap the geodetically inferred inflation sources that drove uplift of the resurgent dome associated with caldera unrest between 1980 and 2000, and they likely reflect the ascent path for magma or magmatic fluids into the upper crust beneath the caldera.

  3. A Big Data Analytics Pipeline for the Analysis of TESS Full Frame Images

    NASA Astrophysics Data System (ADS)

    Wampler-Doty, Matthew; Pierce Doty, John

    2015-12-01

    We present a novel method for producing a catalogue of extra-solar planets and transients using the full frame image data from TESS. Our method involves (1) creating a fast Monte Carlo simulation of the TESS science instruments, (2) using the simulation to create a labeled dataset consisting of exoplanets with various orbital durations as well as transients (such as tidal disruption events), (3) using supervised machine learning to find optimal matched filters, Support Vector Machines (SVMs) and statistical classifiers (i.e. naïve Bayes and Markov Random Fields) to detect astronomical objects of interest and (4) “Big Data” analysis to produce a catalogue based on the TESS data. We will apply the resulting methods to all stars in the full frame images. We hope that by providing libraries that conform to industry standards of Free Open Source Software we may invite researchers from the astronomical community as well as the wider data-analytics community to contribute to our effort.

  4. Advanced qualification of pharmaceutical excipient suppliers by multiple analytics and multivariate analysis combined.

    PubMed

    Hertrampf, A; Müller, H; Menezes, J C; Herdling, T

    2015-11-10

    Pharmaceutical excipients have different functions within a drug formulation, consequently they can influence the manufacturability and/or performance of medicinal products. Therefore, critical to quality attributes should be kept constant. Sometimes it may be necessary to qualify a second supplier, but its product will not be completely equal to the first supplier product. To minimize risks of not detecting small non-similarities between suppliers and to detect lot-to-lot variability for each supplier, multivariate data analysis (MVA) can be used as a more powerful alternative to classical quality control that uses one-parameter-at-a-time monitoring. Such approach is capable of supporting the requirements of a new guideline by the European Parliament and Council (2015/C-95/02) demanding appropriate quality control strategies for excipients based on their criticality and supplier risks in ensuring quality, safety and function. This study compares calcium hydrogen phosphate from two suppliers. It can be assumed that both suppliers use different manufacturing processes. Therefore, possible chemical and physical differences were investigated by using Raman spectroscopy, laser diffraction and X-ray powder diffraction. Afterwards MVA was used to extract relevant information from each analytical technique. Both CaHPO4 could be discriminated by their supplier. The gained knowledge allowed to specify an enhanced strategy for second supplier qualification.

  5. Network Traffic Analysis With Query Driven VisualizationSC 2005HPC Analytics Results

    SciTech Connect

    Stockinger, Kurt; Wu, Kesheng; Campbell, Scott; Lau, Stephen; Fisk, Mike; Gavrilov, Eugene; Kent, Alex; Davis, Christopher E.; Olinger,Rick; Young, Rob; Prewett, Jim; Weber, Paul; Caudell, Thomas P.; Bethel,E. Wes; Smith, Steve

    2005-09-01

    Our analytics challenge is to identify, characterize, and visualize anomalous subsets of large collections of network connection data. We use a combination of HPC resources, advanced algorithms, and visualization techniques. To effectively and efficiently identify the salient portions of the data, we rely on a multi-stage workflow that includes data acquisition, summarization (feature extraction), novelty detection, and classification. Once these subsets of interest have been identified and automatically characterized, we use a state-of-the-art-high-dimensional query system to extract data subsets for interactive visualization. Our approach is equally useful for other large-data analysis problems where it is more practical to identify interesting subsets of the data for visualization than to render all data elements. By reducing the size of the rendering workload, we enable highly interactive and useful visualizations. As a result of this work we were able to analyze six months worth of data interactively with response times two orders of magnitude shorter than with conventional methods.

  6. A semi-analytical formulation for the elastoplastic analysis of imperfect cylindrical shells

    NASA Astrophysics Data System (ADS)

    Deerenberg, E.

    1991-12-01

    A semi-analytical formulation for the elastoplastic analysis of initially imperfect cylindrical shells under axial compression and lateral pressure was developed. The formulation is based on a small strain, moderate rotation shell theory and small strain incremental constitutive theory. The basic shell equations and the partially inverted constitutive relations in total form are reduced to a set of coupled nonlinear algebraic/ordinary differential equations by means of a Fourier decomposition of the state variables, imperfections and loads in circumferential direction of the shell, and application of Galerkin's method. The governing nonlinear equations are solved with an incremental iterative technique. The method of quasilinearization is used to generate the governing equations of the iterative procedure which consistently takes into account both geometrical and material nonlinearities. Plasticity effects are described using a layered approach. The classical flow theory based on the von Mises yield surface, associative flow rule, and the isotropic hardening law is used to describe the evolution of the plastic strains in the integration points. In every iteration a set of linear ordinary differential equations is solved numerically with a shooting method and a return mapping algorithm is used to integrate the constitutive equations locally. A number of elastic and elastoplastic buckling problems are solved for which results are known from literature. It is shown that the quadratic rate of convergence, characteristic for a Newton type iteration procedure, is retained even for large load steps. A comparison between the present results and the results from literature shows a good agreement.

  7. Analytical model and stability analysis of the leading edge spar of a passively morphing ornithopter wing.

    PubMed

    Wissa, Aimy; Calogero, Joseph; Wereley, Norman; Hubbard, James E; Frecker, Mary

    2015-10-26

    This paper presents the stability analysis of the leading edge spar of a flapping wing unmanned air vehicle with a compliant spine inserted in it. The compliant spine is a mechanism that was designed to be flexible during the upstroke and stiff during the downstroke. Inserting a variable stiffness mechanism into the leading edge spar affects its structural stability. The model for the spar-spine system was formulated in terms of the well-known Mathieu's equation, in which the compliant spine was modeled as a torsional spring with a sinusoidal stiffness function. Experimental data was used to validate the model and results show agreement within 11%. The structural stability of the leading edge spar-spine system was determined analytically and graphically using a phase plane plot and Strutt diagrams. Lastly, a torsional viscous damper was added to the leading edge spar-spine model to investigate the effect of damping on stability. Results show that for the un-damped case, the leading edge spar-spine response was stable and bounded; however, there were areas of instability that appear for a range of spine upstroke and downstroke stiffnesses. Results also show that there exist a damping ratio between 0.2 and 0.5, for which the leading edge spar-spine system was stable for all values of spine upstroke and downstroke stiffnesses.

  8. Advanced organic analysis and analytical methods development: FY 1995 progress report. Waste Tank Organic Safety Program

    SciTech Connect

    Wahl, K.L.; Campbell, J.A.; Clauss, S.A.

    1995-09-01

    This report describes the work performed during FY 1995 by Pacific Northwest Laboratory in developing and optimizing analysis techniques for identifying organics present in Hanford waste tanks. The main focus was to provide a means for rapidly obtaining the most useful information concerning the organics present in tank waste, with minimal sample handling and with minimal waste generation. One major focus has been to optimize analytical methods for organic speciation. Select methods, such as atmospheric pressure chemical ionization mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry, were developed to increase the speciation capabilities, while minimizing sample handling. A capillary electrophoresis method was developed to improve separation capabilities while minimizing additional waste generation. In addition, considerable emphasis has been placed on developing a rapid screening tool, based on Raman and infrared spectroscopy, for determining organic functional group content when complete organic speciation is not required. This capability would allow for a cost-effective means to screen the waste tanks to identify tanks that require more specialized and complete organic speciation to determine tank safety.

  9. GeneAnalytics Pathway Analysis and Genetic Overlap among Autism Spectrum Disorder, Bipolar Disorder and Schizophrenia

    PubMed Central

    Khanzada, Naveen S.; Butler, Merlin G.; Manzardo, Ann M.

    2017-01-01

    Bipolar disorder (BPD) and schizophrenia (SCH) show similar neuropsychiatric behavioral disturbances, including impaired social interaction and communication, seen in autism spectrum disorder (ASD) with multiple overlapping genetic and environmental influences implicated in risk and course of illness. GeneAnalytics software was used for pathway analysis and genetic profiling to characterize common susceptibility genes obtained from published lists for ASD (792 genes), BPD (290 genes) and SCH (560 genes). Rank scores were derived from the number and nature of overlapping genes, gene-disease association, tissue specificity and gene functions subdivided into categories (e.g., diseases, tissues or functional pathways). Twenty-three genes were common to all three disorders and mapped to nine biological Superpathways including Circadian entrainment (10 genes, score = 37.0), Amphetamine addiction (five genes, score = 24.2), and Sudden infant death syndrome (six genes, score = 24.1). Brain tissues included the medulla oblongata (11 genes, score = 2.1), thalamus (10 genes, score = 2.0) and hypothalamus (nine genes, score = 2.0) with six common genes (BDNF, DRD2, CHRNA7, HTR2A, SLC6A3, and TPH2). Overlapping genes impacted dopamine and serotonin homeostasis and signal transduction pathways, impacting mood, behavior and physical activity level. Converging effects on pathways governing circadian rhythms support a core etiological relationship between neuropsychiatric illnesses and sleep disruption with hypoxia and central brain stem dysfunction. PMID:28264500

  10. Solid waste facilities location using of analytical network process and data envelopment analysis approaches.

    PubMed

    Khadivi, M R; Fatemi Ghomi, S M T

    2012-06-01

    Selection of the appropriate site for solid waste facilities is a complex problem and requires an extensive evaluation process, because it is very difficult to develop a selection criterion that can precisely describe the preference of one location over another. Therefore selection of these sites can be viewed as a multiple criteria decision-making or multiple attributes decision-making problem. For this purpose, we propose a technique that can effectively take managerial preferences and subjective data into consideration, along with quantitative factors. The tool proposed here relies on the use of the analytical network process (ANP) and to help integrate managerial evaluations into a more quantitatively based decision tool, data envelopment analysis (DEA) is applied. In this paper, a location selection procedure is presented to construct an undesirable facility applying ANP and DEA approaches in two stages. In the first stage ANP approach is used, results of this stage are inputs for the second stage. In this stage, DEA is applied to select the best location. Finally, to illustrate the proposed framework, at "Results and discussion" section, a total of four undesirable facility locations are evaluated.

  11. Shape Analysis of DNA-Au Hybrid Particles by Analytical Ultracentrifugation.

    PubMed

    Urban, Maximilan J; Holder, Isabelle T; Schmid, Marius; Fernandez Espin, Vanesa; Garcia de la Torre, Jose; Hartig, Jörg S; Cölfen, Helmut

    2016-08-23

    Current developments in nanotechnology have increased the demand for nanocrystal assemblies with well-defined shapes and tunable sizes. DNA is a particularly well-suited building block in nanoscale assemblies because of its scalable sizes, conformational variability, and convenient self-assembly capabilities via base pairing. In hybrid materials, gold nanoparticles (AuNPs) can be assembled into nanoparticle structures with programmable interparticle distances by applying appropriate DNA sequences. However, the development of stoichiometrically defined DNA/NP structures is still challenging since product mixtures are frequently obtained and their purification and characterization is the rate-limiting step in the development of DNA-NP hybrid assemblies. Improvements in nanostructure fractionation and characterization techniques offer great potential for nanotechnology applications in general. This study reports the application of analytical ultracentrifugation (AUC) for the characterization of anisotropic DNA-linked metal-crystal assemblies. On the basis of transmission electron microscopy data and the DNA primary sequence, hydrodynamic bead models are set up for the interpretation of the measured frictional ratios and sedimentation coefficients. We demonstrate that the presence of single DNA strands on particle surfaces as well as the shape factors of multiparticle structures in mixtures can be quantitatively described by AUC. This study will significantly broaden the possibilities to analyze mixtures of shape-anisotropic nanoparticle assemblies. By establishing insights into the analysis of nanostructure mixtures based on fundamental principles of sedimentation, a wide range of potential applications in basic research and industry become accessible.

  12. Structural damage localization by outlier analysis of signal-processed mode shapes - Analytical and experimental validation

    NASA Astrophysics Data System (ADS)

    Ulriksen, M. D.; Damkilde, L.

    2016-02-01

    Contrary to global modal parameters such as eigenfrequencies, mode shapes inherently provide structural information on a local level. Therefore, this particular modal parameter and its derivatives are utilized extensively for damage identification. Typically, more or less advanced mathematical methods are employed to identify damage-induced discontinuities in the spatial mode shape signals, hereby, potentially, facilitating damage detection and/or localization. However, by being based on distinguishing damage-induced discontinuities from other signal irregularities, an intrinsic deficiency in these methods is the high sensitivity towards measurement noise. In the present paper, a damage localization method which, compared to the conventional mode shape-based methods, has greatly enhanced robustness towards measurement noise is proposed. The method is based on signal processing of a spatial mode shape by means of continuous wavelet transformation (CWT) and subsequent application of a generalized discrete Teager-Kaiser energy operator (GDTKEO) to identify damage-induced mode shape discontinuities. In order to evaluate whether the identified discontinuities are in fact damage-induced, outlier analysis is conducted by applying the Mahalanobis metric to major principal scores of the sensor-located bands of the signal-processed mode shape. The method is tested analytically and benchmarked with other mode shape-based damage localization approaches on the basis of a free-vibrating beam and validated experimentally in the context of a residential-sized wind turbine blade subjected to an impulse load.

  13. Improved analytic extreme-mass-ratio inspiral model for scoping out eLISA data analysis

    NASA Astrophysics Data System (ADS)

    Chua, Alvin J. K.; Gair, Jonathan R.

    2015-12-01

    The space-based gravitational-wave detector eLISA has been selected as the ESA L3 mission, and the mission design will be finalized by the end of this decade. To prepare for mission formulation over the next few years, several outstanding and urgent questions in data analysis will be addressed using mock data challenges, informed by instrument measurements from the LISA Pathfinder satellite launching at the end of 2015. These data challenges will require accurate and computationally affordable waveform models for anticipated sources such as the extreme-mass-ratio inspirals (EMRIs) of stellar-mass compact objects into massive black holes. Previous data challenges have made use of the well-known analytic EMRI waveforms of Barack and Cutler, which are extremely quick to generate but dephase relative to more accurate waveforms within hours, due to their mismatched radial, polar and azimuthal frequencies. In this paper, we describe an augmented Barack-Cutler model that uses a frequency map to the correct Kerr frequencies, along with updated evolution equations and a simple fit to a more accurate model. The augmented waveforms stay in phase for months and may be generated with virtually no additional computational cost.

  14. A Systematic Mapping on the Learning Analytics Field and Its Analysis in the Massive Open Online Courses Context

    ERIC Educational Resources Information Center

    Moissa, Barbara; Gasparini, Isabela; Kemczinski, Avanilde

    2015-01-01

    Learning Analytics (LA) is a field that aims to optimize learning through the study of dynamical processes occurring in the students' context. It covers the measurement, collection, analysis and reporting of data about students and their contexts. This study aims at surveying existing research on LA to identify approaches, topics, and needs for…

  15. moocRP: Enabling Open Learning Analytics with an Open Source Platform for Data Distribution, Analysis, and Visualization

    ERIC Educational Resources Information Center

    Pardos, Zachary A.; Whyte, Anthony; Kao, Kevin

    2016-01-01

    In this paper, we address issues of transparency, modularity, and privacy with the introduction of an open source, web-based data repository and analysis tool tailored to the Massive Open Online Course community. The tool integrates data request/authorization and distribution workflow features as well as provides a simple analytics module upload…

  16. An analytical solution of the Fokker-Planck equation in the phase-locked loop transient analysis

    NASA Technical Reports Server (NTRS)

    Zhang, Weijian

    1987-01-01

    A probabilistic approach is used to obtain an analytical solution to the Fokker-Planck equation used in the transient analysis of the phase-locked loop phase error process of the first-order phase-locked loop. The solution procedure, which is based on the Girsanov transformation, is described.

  17. Cost Analysis of an Air Brayton Receiver for a Solar Thermal Electric Power System in Selected Annual Production Volumes

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Pioneer Engineering and Manufacturing Company estimated the cost of manufacturing and Air Brayton Receiver for a Solar Thermal Electric Power System as designed by the AiResearch Division of the Garrett Corporation. Production costs were estimated at annual volumes of 100; 1,000; 5,000; 10,000; 50,000; 100,000 and 1,000,000 units. These costs included direct labor, direct material and manufacturing burden. A make or buy analysis was made of each part of each volume. At high volumes special fabrication concepts were used to reduce operation cycle times. All costs were estimated at an assumed 100% plant capacity. Economic feasibility determined the level of production at which special concepts were to be introduced. Estimated costs were based on the economics of the last half of 1980. Tooling and capital equipment costs were estimated for ach volume. Infrastructure and personnel requirements were also estimated.

  18. Crustal and upper mantle structure beneath the northeastern Tibetan Plateau from joint analysis of receiver functions and Rayleigh wave dispersions

    NASA Astrophysics Data System (ADS)

    Zheng, Dan; Li, Hongyi; Shen, Yang; Tan, Jing; Ouyang, Longbin; Li, Xinfu

    2016-01-01

    The crustal and upper mantle velocity structure in the northeastern Tibetan Plateau is obtained from joint analysis of receiver functions and Rayleigh wave dispersions. The resulting velocity model reveals a close correlation between the thick (>60 km) crust and the presence of an intracrustal low-velocity zone beneath the Qiangtang and Songpan-Ganzi terranes as well as the northwestern Qilian orogen. However, the high Vp/Vs ratio of the crust is found only beneath the Qiangtang and Songpan-Ganzi terranes. The crustal low velocity zone does not appear in the west Qinling and southeastern Qilian orogens, which have a relatively thin (˜50 km) crust, indicating that crustal channel flow is not the primary mechanism by which the northeastern Tibetan Plateau grows. A continuous low velocity zone from the mid-to-lower crust down to 160 km beneath the eastern Kunlun fault suggests an induced local mantle upwelling after partial detachment of the lithosphere.

  19. Total cyanide analysis of tank core samples: Analytical results and supporting investigations. Revision 1

    SciTech Connect

    Pool, K.H.

    1994-03-01

    The potential for a ferrocyanide explosion in Hanford site single-shelled waste storage tanks (SSTS) poses a serious safety concern. This potential danger developed in the 1950s when {sup 137}Cs was scavenged during the reprocessing of uranium recovery process waste by co-precipitating it along with sodium in nickel ferrocyanide salt. Sodium or potassium ferrocyanide and nickel sulfate were added to the liquid waste stored in SSTs. The tank storage space resulting from the scavenging process was subsequently used to store other waste types. Ferrocyanide salts in combinations with oxidizing agents, such as nitrate and nitrite, are known to explode when key parameters (temperature, water content, oxidant concentration, and fuel [cyanide]) are in place. Therefore, reliable total cyanide analysis data for actual SST materials are required to address the safety issue. Accepted cyanide analysis procedures do not yield reliable results for samples containing nickel ferrocyanide materials because the compounds are insoluble in acidic media. Analytical chemists at Pacific Northwest Laboratory (PNL) have developed a modified microdistillation procedure (see below) for analyzing total cyanide in waste tank matrices containing nickel ferrocyanide materials. Pacific Northwest Laboratory analyzed samples from Hanford Waste Tank 241-C-112 cores 34, 35, and 36 for total cyanide content using technical procedure PNL-ALO-285 {open_quotes}Total Cyanide by Remote Microdistillation and Agrentometric Titration,{close_quotes} Rev. 0. This report summarizes the results of these analyses along with supporting quality control data, and, in addition, summarizes the results of the test to check the efficacy of sodium nickel ferrocyanide solubilization from an actual core sample by aqueous EDTA/en to verify that nickel ferrocyanide compounds were quantitatively solubilized before actual distillation.

  20. Integrated Data Collection Analysis (IDCA) Program — KClO3 (as received)/Icing Sugar

    SciTech Connect

    Sandstrom, Mary M.; Brown, Geoffrey W.; Preston, Daniel N.; Pollard, Colin J.; Warner, Kirstin F.; Sorenson, Daniel N.; Remmers, Daniel L.; Shelley, Timothy J.; Reyes, Jose A.; Hsu, Peter C.; Whipple, Richard E.; Reynolds, John G.

    2011-05-23

    The Integrated Data Collection Analysis (IDCA) program is conducting a proficiency study for Small-Scale Safety and Thermal (SSST) testing of homemade explosives (HMEs). Described here are the results for impact, friction, electrostatic discharge, and differential scanning calorimetry analysis of a mixture of KClO3 as received from the manufacturer mixed with icing sugar, sized through a 100-mesh sieve—KClO3/icing sugar (AR) mixture. This material was selected because of the challenge of performing SSST testing of a mixture of two solid materials. The mixture was found to: 1) be more sensitive to impact than RDX, similar to PETN, 2) be the same or less sensitive to friction than PETN, and 3) to be less sensitive to spark than RDX. The thermal analysis showed that the mixture has thermally stability similar to RDX and is perhaps more energetic upon decomposition but variable results indicate sampling issues. Compared to the 100-mesh sieved counter part, the KClO3/icing sugar (-100) mixture, the AR mixture was found to be about the same sensitivity towards impact, friction and ESD.

  1. Sensitivity analysis of laboratory based mine overburden analytical techniques for the prediction of acidic mine drainage. Final report

    SciTech Connect

    Bradham, W.S.; Caruccio, F.T.

    1995-09-01

    A three part sensitivity analysis was conducted to evaluate commonly used mine overburden analytical techniques. The primary objectives of the study were: identify and evaluate the effects of variability in mine overburden geochemistry, as measured by pyrite weight percent and neutralization potential (NP), on variability of contaminant production; determine which acid/base accounting interpretation technique best predicts both qualitative and quantitative leachate quality in laboratory analytical testing; and identify the predominant factors of weathering cells, soxhlet extraction, and column leaching tests, and evaluate variability of contaminant production due to variations in; storage conditions, leachant temperature, particle size, particle sorting efficiency, and leaching interval.

  2. Radiation receiver

    DOEpatents

    Hunt, A.J.

    1983-09-13

    The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles. 5 figs.

  3. Radiation receiver

    DOEpatents

    Hunt, Arlon J.

    1983-01-01

    The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles.

  4. Comparison of analytical and numerical analysis of the reference region model for DCE-MRI.

    PubMed

    Lee, Joonsang; Cárdenas-Rodríguez, Julio; Pagel, Mark D; Platt, Simon; Kent, Marc; Zhao, Qun

    2014-09-01

    This study compared three methods for analyzing DCE-MRI data with a reference region (RR) model: a linear least-square fitting with numerical analysis (LLSQ-N), a nonlinear least-square fitting with numerical analysis (NLSQ-N), and an analytical analysis (NLSQ-A). The accuracy and precision of estimating the pharmacokinetic parameter ratios KR and VR, where KR is defined as a ratio between the two volume transfer constants, K(trans,TOI) and K(trans,RR), and VR is the ratio between the two extracellular extravascular volumes, ve,TOI and ve,RR, were assessed using simulations under various signal-to-noise ratios (SNRs) and temporal resolutions (4, 6, 30, and 60s). When no noise was added, the simulations showed that the mean percent error (MPE) for the estimated KR and VR using the LLSQ-N and NLSQ-N methods ranged from 1.2% to 31.6% with various temporal resolutions while the NLSQ-A method maintained a very high accuracy (<1.0×10(-4) %) regardless of the temporal resolution. The simulation also indicated that the LLSQ-N and NLSQ-N methods appear to underestimate the parameter ratios more than the NLSQ-A method. In addition, seven in vivo DCE-MRI datasets from spontaneously occurring canine brain tumors were analyzed with each method. Results for the in vivo study showed that KR (ranging from 0.63 to 3.11) and VR (ranging from 2.82 to 19.16) for the NLSQ-A method were both higher than results for the other two methods (KR ranging from 0.01 to 1.29 and VR ranging from 1.48 to 19.59). A temporal downsampling experiment showed that the averaged percent error for the NLSQ-A method (8.45%) was lower than the other two methods (22.97% for LLSQ-N and 65.02% for NLSQ-N) for KR, and the averaged percent error for the NLSQ-A method (6.33%) was lower than the other two methods (6.57% for LLSQ-N and 13.66% for NLSQ-N) for VR. Using simulations, we showed that the NLSQ-A method can estimate the ratios of pharmacokinetic parameters more accurately and precisely than the NLSQ-N and

  5. Safety analysis, 200 Area, Savannah River Plant: Separations area operations. Receiving Basin for Offsite Fuel (Supplement 3)

    SciTech Connect

    Allen, P M

    1983-09-01

    Analysis of the Savannah River Plant RBOF and RRF included an evaluation of the reliability of process equipment and controls, administrative controls, and engineered safety features. The evaluation also identified potential scenarios and radiological consequences. Risks were calculated in terms of 50-year population dose commitment per year (man-rem/year) to the onsite and offsite population within an 80 Km radius of RBOF and RRF, and to an individual at the plant boundary. The total 50-year onsite and offsite population radiological risks of operating the RBOF and RRF were estimated to be 1.0 man-rem/year. These risks are significantly less than the population dose of 54,000 man/rem/yr for natural background radiation in a 50-mile radius. The 50-year maximum offsite individual risk from operating the facility was estimated to be 2.1 {times} 10{sup 5} rem/yr. These risks are significantly lower than 93 mrem/yr an individual is expected to receive from natural background radiation in this area. The analysis shows. that the RBOF and RRF can be operated without undue risk to onsite personnel or to the general public.

  6. Outcomes in Ethnic Minority Renal Transplant Recipients Receiving Everolimus versus Mycophenolate: Comparative Risk Assessment Results From a Pooled Analysis

    PubMed Central

    Melancon, Keith; Mulgaonkar, Shamkant P.; Delcoro, Carlos; Wiland, Anne; McCague, Kevin; Shihab, Fuad S.

    2013-01-01

    Background Everolimus (EVR) has demonstrated good efficacy after renal transplantation. Racial disparities in clinical outcomes after de novo renal transplantation are well documented; whether the efficacy of EVR varies based on recipient ethnicity is unknown. We conducted a comparative risk assessment of EVR by ethnicity. Methods Data on 2004 renal transplant recipients from three EVR studies were pooled to identify the impact of ethnicity on efficacy outcomes across EVR dosing groups and control groups. Ethnic groups compared were African Americans, non-U.S. blacks, Asians, Hispanics, and Caucasians. EVR groups received either 1.5 or 3 mg per day, with either standard-dose cyclosporine or reduced-dose cyclosporine. Control groups received mycophenolic acid (MPA) with standard-dose cyclosporine. Composite efficacy failure endpoint was graft loss, death, biopsy-proven acute rejection, or lost to follow-up. Adjusted odds ratios were calculated using a logistic regression model. Results The proportion of renal transplant recipients who met the composite endpoint was African Americans (46%), non-U.S. black (35%), Caucasian (31%), Hispanic (28%), and Asian (25%). The odds of meeting the composite endpoint were significantly (P=0.0001) greater for African Americans versus Caucasians but did not differ among the other ethnic groups (ethnic groups were only compared with Caucasians). EVR and MPA were associated with similar efficacy among each of the ethnic groups. Conclusion In this pooled data analysis in more than 2000 renal transplant recipients, EVR versus MPA resulted in similar composite endpoint incidence events across ethnicities. Consistent with previously published data, African Americans had poorer clinical outcomes. EVR is efficacious regardless of ethnicity. PMID:24345868

  7. Analysis of hydroponic fertilizer matrixes for perchlorate: comparison of analytical techniques.

    PubMed

    Collette, Timothy W; Williams, Ted L; Urbansky, Edward T; Magnuson, Matthew L; Hebert, Gretchen N; Strauss, Steven H

    2003-01-01

    Seven retail hydroponic nitrate fertilizer products, two liquid and five solid, were comparatively analyzed for the perchlorate anion (ClO4-) by ion chromatography (IC) with suppressed conductivity detection, complexation electrospray ionization mass spectrometry (cESI-MS), normal Raman spectroscopy, and infrared spectroscopy using an attenuated total reflectance crystal (ATR-FTIR) coated with a thin film of an organometallic ion-exchange compound. Three of the five solid products were found by all techniques to contain perchlorate at the level of approximately 100-350 mg kg(-1). The remaining products did not contain perchlorate above the detection level of any of the techniques. Comparative analysis using several analytical techniques that depend on different properties of perchlorate allow for a high degree of certainty in both the qualitative and quantitative determinations. This proved particularly useful for these samples, due to the complexity of the matrix. Analyses of this type, including multiple spectroscopic confirmations, may also be useful for other complicated matrixes (e.g., biological samples) or in forensic/regulatory frameworks where data are likely to be challenged. While the source of perchlorate in these hydroponic products is not known, the perchlorate-to-nitrate concentration ratio (w/w) in the aqueous extracts is generally consistent with the historical weight percent of water soluble components in caliche, a nitrate-bearing ore found predominantly in Chile. This ore, which is the only well-established natural source of perchlorate, is mined and used, albeit minimally, as a nitrogen source in some fertilizer products.

  8. Real-time analysis for intensive care: development and deployment of the artemis analytic system.

    PubMed

    Blount, Marion; Ebling, Maria R; Eklund, J Mikael; James, Andrew G; McGregor, Carolyn; Percival, Nathan; Smith, Kathleen P; Sow, Daby

    2010-01-01

    The lives of many thousands of children born premature or ill at term around the world have been saved by those who work within neonatal intensive care units (NICUs). Modern-day neonatologists, together with nursing staff and other specialists within this domain, enjoy modern technologies for activities such as financial transactions, online purchasing, music, and video on demand. Yet, when they move into their workspace, in many cases, they are supported by nearly the same technology they used 20 years ago. Medical devices provide visual displays of vital signs through physiological streams such as electrocardiogram (ECG), heart rate, blood oxygen saturation (SpO(2)), and respiratory rate. Electronic health record initiatives around the world provide an environment for the electronic management of medical records, but they fail to support the high-frequency interpretation of streaming physiological data. We have taken a collaborative research approach to address this need to provide a flexible platform for the real-time online analysis of patients' data streams to detect medically significant conditions that precede the onset of medical complications. The platform supports automated or clinician-driven knowledge discovery to discover new relationships between physiological data stream events and latent medical conditions as well as to refine existing analytics. Patients benefit from the system because earlier detection of signs of the medical conditions may lead to earlier intervention that may potentially lead to improved patient outcomes and reduced length of stays. The clinician benefits from a decision support tool that provides insight into multiple streams of data that are too voluminous to assess with traditional methods. The remainder of this article summarizes the strengths of our research collaboration and the resulting environment known as Artemis, which is currently being piloted within the NICU of The Hospital for Sick Children (SickKids) in Toronto

  9. Analytical (mathematical) predictive modeling in fiber optics structural analysis (FOSA): review and extension

    NASA Astrophysics Data System (ADS)

    Suhir, Ephraim

    2015-03-01

    An updated version of the paper with revised references has been published The review part of the paper addresses analytical (mathematical) modeling in structural analysis in fiber optics engineering, mostly fiber optics interconnects, and deals with optical fibers subjected to thermal and/or mechanical loading (stresses) in bending, tension, compression, or to the combinations of such loadings. Attributes and significance of predictive modeling are indicated and discussed. The review is based mostly on the author's research conducted at Bell Laboratories, Physical Sciences and Engineering Research Division, Murray Hill, NJ, USA, during his tenure with this company, and, to a lesser extent, on his recent work in the field. The addressed structures include, but are not limited to, optical fibers of finite length: bare fibers; jacketed and dual-coated fibers; fibers experiencing thermal loading; fibers soldered into ferrules or adhesively bonded into capillaries; as well as the roles of geometric and material non-linearity; dynamic response to shocks and vibrations; and possible applications of nano-materials in new generations of coating and cladding systems. The extension part is concerned with a novel, fruitful and challenging directionprobabilistic design for reliability (PDfR) of opto-electronic and photonic products, including optical fibers and interconnects. The rationale behind the PDfR concept is that there is no such thing as zero probability of failure, that the difference between a highly reliable product and an insufficiently reliable product is "merely" in the level of the never zero probability of its failure and that when the operational performance of the product is imperative, the ability to predict, quantify, assure and, if possible and appropriate, even specify its reliability is highly desirable. Accordingly, the objective of the PDfR effort is to quantify the likelihood of an operational failure of a material, device or a system, including the

  10. Analysis of Synthetic Cannabinoids in Botanical Material: A Review of Analytical Methods and Findings.

    PubMed

    Presley, B C; Jansen-Varnum, S A; Logan, B K

    2013-03-01

    Synthetic cannabinoid analogs have gained a great deal of attention from the forensic community within the last four years. The compounds found to be of most interest to forensic practitioners include those of the following series: JWH, CP, HU, AM, WIN, RCS, and most recently, XLR and UR. Structurally the HU compounds are most similar in structure to Δ9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana. The novel compounds include cyclohexylphenols, naphthoylindoles, naphthylmethylindoles, naphthylmethylindenes, benzoylindoles, naphthoylpyrroles, phenylacetylindoles, adamantoylindoles, and tetramethylcyclopropylindoles. Many of these compounds are cannabinoid receptor agonists and were originally synthesized for medical research purposes but have recently been appropriated into the illicit drug market. Their psychoactive effects, mimicking those of marijuana, as well as their indeterminate legal status, have made them popular for recreational use. Solutions of the compounds dissolved in organic solvents are sprayed onto botanical material and sold as "herbal incense" products via the Internet, and in smoke shops, convenience stores, and gas stations around the world. Many of the products are labeled "Not for human consumption" in an attempt to circumvent legislation that bans the sale and manufacture of certain compounds and their analogs for human use. The compounds that were first detected following forensic analysis of botanical materials included JWH-018, JWH-073, and CP 47,497 (C7 and C8 homologs). However, in the four years since their appearance the number of compounds has grown, and additional diverse classes of compounds have been detected. Governments worldwide have taken action in an attempt to control those compounds that have become widespread in their regions. This article discusses the history of synthetic cannabinoids and how they have been detected in the illicit drug market. It also discusses the analytical methods and

  11. OCD RADIO ALERT RECEIVERS.

    DTIC Science & Technology

    for methods of operating a radioalert system were established in conjunction with OCD representatives. Four types of operation were selected. Three...models each of these four receiver types were fabricated and tested. The total of 12 laboratory models were delivered to OCD . Test equipment...suitable for demonstrating the two most promising receiver types was also assembled, and delivered to OCD . A preliminary analysis of the cost of mass

  12. An apparatus for the determination of volatile analytes by stopped-flow injection analysis using an integrated fiber optic detector.

    PubMed

    Baxter, P J; Růzicka, J; Christian, G D; Olson, D C

    1994-03-01

    A new method for the analysis of volatile analytes using a stopped-flow injection system originating from either a gas or liquid phase has been developed. It uses an integrated fiber optic detector which also serves as a reactor. This system combines the advantages of gas diffusion and stopped-flow, making the overall assay very sensitive. Both gas streams and aqueous solutions containing ammonia were analyzed. The limits of detection are 40 ppb for gas phase analysis and 1.0 ppm for aqueous phase analysis.

  13. A Statistical Comparison of the Blossom Blight Forecasts of MARYBLYT and Cougarblight with Receiver Operating Characteristic Curve Analysis.

    PubMed

    Dewdney, M M; Biggs, A R; Turechek, W W

    2007-09-01

    ABSTRACT Blossom blight forecasting is an important aspect of fire blight, caused by Erwinia amylovora, management for both apple and pear. A comparison of the forecast accuracy of two common fire blight forecasters, MARYBLYT and Cougarblight, was performed with receiver operating characteristic (ROC) curve analysis and 243 data sets. The rain threshold of Cougarblight was analyzed as a separate model termed Cougarblight and rain. Data were used as a whole and then grouped into geographic regions and cultivar susceptibilities. Frequency distributions of cases and controls, orchards or regions (depending on the data set), with and without observed disease, respectively, in all data sets overlapped. MARYBLYT, Cougarblight, and Cougarblight and rain all predicted blossom blight infection better than chance (P = 0.05). It was found that the blossom blight forecasters performed equivalently in the geographic regions of the east and west coasts of North America and moderately susceptible cultivars based on the 95% confidence intervals and pairwise contrasts of the area under the ROC curve. Significant differences (P < 0.05) between the forecasts of Cougarblight and MARYBLYT were found with pairwise contrasts in the England and very susceptible cultivar data sets. Youden's index was used to determine the optimal cutpoint of both forecasters. The greatest sensitivity and specificity for MARYBLYT coincided with the use of the highest risk threshold for predictions of infection; with Cougarblight, there was no clear single risk threshold across all data sets.

  14. Prediction of preterm and low birth weight delivery by maternal periodontal parameters: receiver operating characteristic (ROC) curve analysis.

    PubMed

    Al Habashneh, Rola; Khader, Yousef S; Jabali, Olfat Al; Alchalabi, Haifa'a

    2013-02-01

    In this study we used receiver-operating characteristic (ROC) analysis to comparatively evaluate maternal periodontal parameters to predict preterm (PB) delivery and low birth weight (LBW) delivery among Jordanian women. A total of 277 pregnant women (20 weeks of gestation or less) had periodontal examination at baseline and followed up until delivery. Gestational age and birth weight were retrieved from their medical records. ROC curve analyses were used to examine the overall discriminatory power of the studied periodontal parameters to predict PB, LBW, and PB or LBW. For the three outcome variables, the area under curve (AUC) ranged from 0.84 to 0.87 for average clinical attachment level (CAL), 0.78-0.86 for percent of sites with CAL ≥ 5 mm, 0.63-0.74 for percent of sites with CAL ≥ 6 mm, and 0.71-0.82 for number of missing teeth indicating that they had high discriminating power to predict adverse pregnancy outcomes. All other parameters had AUC less than 0.60 and thus had low discriminating power. Average CAL performed the best in predicting the studied adverse pregnancy outcomes because it has the highest AUC. The severity and extent of periodontal disease as measured by CAL can be used to predict the occurrence of adverse pregnancy outcomes.

  15. Policy-Making Theory as an Analytical Framework in Policy Analysis: Implications for Research Design and Professional Advocacy.

    PubMed

    Sheldon, Michael R

    2016-01-01

    Policy studies are a recent addition to the American Physical Therapy Association's Research Agenda and are critical to our understanding of various federal, state, local, and organizational policies on the provision of physical therapist services across the continuum of care. Policy analyses that help to advance the profession's various policy agendas will require relevant theoretical frameworks to be credible. The purpose of this perspective article is to: (1) demonstrate the use of a policy-making theory as an analytical framework in a policy analysis and (2) discuss how sound policy analysis can assist physical therapists in becoming more effective change agents, policy advocates, and partners with other relevant stakeholder groups. An exploratory study of state agency policy responses to address work-related musculoskeletal disorders is provided as a contemporary example to illustrate key points and to demonstrate the importance of selecting a relevant analytical framework based on the context of the policy issue under investigation.

  16. Blade loss transient dynamics analysis, volume 2. Task 2: Theoretical and analytical development. Task 3: Experimental verification

    NASA Technical Reports Server (NTRS)

    Gallardo, V. C.; Storace, A. S.; Gaffney, E. F.; Bach, L. J.; Stallone, M. J.

    1981-01-01

    The component element method was used to develop a transient dynamic analysis computer program which is essentially based on modal synthesis combined with a central, finite difference, numerical integration scheme. The methodology leads to a modular or building-block technique that is amenable to computer programming. To verify the analytical method, turbine engine transient response analysis (TETRA), was applied to two blade-out test vehicles that had been previously instrumented and tested. Comparison of the time dependent test data with those predicted by TETRA led to recommendations for refinement or extension of the analytical method to improve its accuracy and overcome its shortcomings. The development of working equations, their discretization, numerical solution scheme, the modular concept of engine modelling, the program logical structure and some illustrated results are discussed. The blade-loss test vehicles (rig full engine), the type of measured data, and the engine structural model are described.

  17. Analytical performance of three commonly used extraction methods for the gas chromatography-mass spectrometry analysis of wine volatile compounds.

    PubMed

    Andujar-Ortiz, I; Moreno-Arribas, M V; Martín-Alvarez, P J; Pozo-Bayón, M A

    2009-10-23

    The analytical performance of three extraction procedures based on cold liquid-liquid extraction using dicloromethane (LLE), solid phase extraction (SPE) using a styrene-divinylbenzene copolymer and headspace solid phase microextraction (SPME) using a carboxen-polydimethylsiloxane coated fibre has been evaluated based on the analysis of 30 representative wine volatile compounds. From the comparison of the three procedures, LLE and SPE showed very good linearity covering a wide range of concentrations of wine volatile compounds, low detection limits, high recovery for most of the volatile compounds under study and higher sensitivity compared to the headspace-SPME procedure. The latter showed in general, poor recovery for polar volatile compounds. Despite some drawbacks associated with the LLE and SPE procedures such as the more tedious sampling treatment and the use of organic solvents, the analytical performance of both procedures showed that they are more adequate for the analysis of wine volatiles.

  18. GeneAnalytics: An Integrative Gene Set Analysis Tool for Next Generation Sequencing, RNAseq and Microarray Data

    PubMed Central

    Ben-Ari Fuchs, Shani; Lieder, Iris; Mazor, Yaron; Buzhor, Ella; Kaplan, Sergey; Bogoch, Yoel; Plaschkes, Inbar; Shitrit, Alina; Rappaport, Noa; Kohn, Asher; Edgar, Ron; Shenhav, Liraz; Safran, Marilyn; Lancet, Doron; Guan-Golan, Yaron; Warshawsky, David; Shtrichman, Ronit

    2016-01-01

    Abstract Postgenomics data are produced in large volumes by life sciences and clinical applications of novel omics diagnostics and therapeutics for precision medicine. To move from “data-to-knowledge-to-innovation,” a crucial missing step in the current era is, however, our limited understanding of biological and clinical contexts associated with data. Prominent among the emerging remedies to this challenge are the gene set enrichment tools. This study reports on GeneAnalytics™ (geneanalytics.genecards.org), a comprehensive and easy-to-apply gene set analysis tool for rapid contextualization of expression patterns and functional signatures embedded in the postgenomics Big Data domains, such as Next Generation Sequencing (NGS), RNAseq, and microarray experiments. GeneAnalytics' differentiating features include in-depth evidence-based scoring algorithms, an intuitive user interface and proprietary unified data. GeneAnalytics employs the LifeMap Science's GeneCards suite, including the GeneCards®—the human gene database; the MalaCards—the human diseases database; and the PathCards—the biological pathways database. Expression-based analysis in GeneAnalytics relies on the LifeMap Discovery®—the embryonic development and stem cells database, which includes manually curated expression data for normal and diseased tissues, enabling advanced matching algorithm for gene–tissue association. This assists in evaluating differentiation protocols and discovering biomarkers for tissues and cells. Results are directly linked to gene, disease, or cell “cards” in the GeneCards suite. Future developments aim to enhance the GeneAnalytics algorithm as well as visualizations, employing varied graphical display items. Such attributes make GeneAnalytics a broadly applicable postgenomics data analyses and interpretation tool for translation of data to knowledge-based innovation in various Big Data fields such as precision medicine, ecogenomics, nutrigenomics

  19. Studying Crust and Upper Mantle Structure in Eastern Canada with High-Resolution Teleseismic Receiver Function Analysis

    NASA Astrophysics Data System (ADS)

    Wang, B.; Darbyshire, F. A.; Gao, S. S.

    2012-12-01

    Teleseismic receiver function (RF) analysis is an important technique that is widely used in studying the Earth's crust and upper mantle structure. A critical step of this technique is the RF calculation which is an unstable deconvolution procedure. A spline-based RF calculation method is developed, and it is demonstrated that the stacked spline-based RFs have higher resolution than the stacked RFs calculated with the water-level spectral division and iterative deconvolution methods. The better RFs calculated with the spline method lead to improved determination of the optimal Moho depths and Vp/Vs ratios with greater resolution and clarity, albeit compatible optimal Moho depths and Vp/Vs ratios are obtained by employing all three RF calculation methods. In contrast to the iterative deconvolution and water-level spectral division methods, there is less extensive strap of high values on the H-k analysis image and the maximum peak is substantially sharper for the spline method. The broadband seismogram data are acquired at 9 stations of the UQAM / POLARIS Seismograph Network in Quebec in the Superior Province and Greenville Province of the Canadian Shield. Nice PmS converted phase is clearly seen for all the stations. The crustal thickness ranges from 32.5 km to 38.9 km, and the Vp/Vs ratio from 1.68 to 1.83. Several stations show excellent coherent signals of the converted phases on both the radial and tangential RFs over a range of backazimuthal variations. This would indicate evidence for intra-crustal and significant 3D and/or anisotropic structure. More detailed forward and inverse modeling of the lithospheric structure and comparison with other geological and geophysical data and information are in progress.

  20. Big Data Geo-Analytical Tool Development for Spatial Analysis Uncertainty Visualization and Quantification Needs

    NASA Astrophysics Data System (ADS)

    Rose, K.; Bauer, J. R.; Baker, D. V.

    2015-12-01

    As big data computing capabilities are increasingly paired with spatial analytical tools and approaches, there is a need to ensure uncertainty associated with the datasets used in these analyses is adequately incorporated and portrayed in results. Often the products of spatial analyses, big data and otherwise, are developed using discontinuous, sparse, and often point-driven data to represent continuous phenomena. Results from these analyses are generally presented without clear explanations of the uncertainty associated with the interpolated values. The Variable Grid Method (VGM) offers users with a flexible approach designed for application to a variety of analyses where users there is a need to study, evaluate, and analyze spatial trends and patterns while maintaining connection to and communicating the uncertainty in the underlying spatial datasets. The VGM outputs a simultaneous visualization representative of the spatial data analyses and quantification of underlying uncertainties, which can be calculated using data related to sample density, sample variance, interpolation error, uncertainty calculated from multiple simulations. In this presentation we will show how we are utilizing Hadoop to store and perform spatial analysis through the development of custom Spark and MapReduce applications that incorporate ESRI Hadoop libraries. The team will present custom 'Big Data' geospatial applications that run on the Hadoop cluster and integrate with ESRI ArcMap with the team's probabilistic VGM approach. The VGM-Hadoop tool has been specially built as a multi-step MapReduce application running on the Hadoop cluster for the purpose of data reduction. This reduction is accomplished by generating multi-resolution, non-overlapping, attributed topology that is then further processed using ESRI's geostatistical analyst to convey a probabilistic model of a chosen study region. Finally, we will share our approach for implementation of data reduction and topology generation

  1. Responder Analysis of the Effects of Denosumab on Bone Mineral Density in Men Receiving Androgen Deprivation Therapy for Prostate Cancer

    PubMed Central

    Egerdie, Blair; Saad, Fred; Smith, Matthew R; Tammela, Teuvo LJ; Heracek, Jiri; Sieber, Paul; Ke, Chunlei; Leder, Benjamin; Dansey, Roger; Goessl, Carsten

    2013-01-01

    Background Men with prostate cancer are at risk of experiencing accelerated bone loss and fractures as a result of androgen deprivation therapy (ADT). Objective We evaluated the effects of denosumab, a fully human monoclonal antibody against RANKL, on preservation of BMD at 3 key skeletal sites (lumbar spine [LS], femoral neck [FN], and total hip [TH]) and the distal radius at 36 months both by responder category and individual responses in a waterfall plot analysis. Design, Setting, and Participants This phase 3, randomized, double-blind study of men with non-metastatic prostate cancer receiving ADT investigated the effects of denosumab on bone mineral density (BMD) and fractures. Patients were treated for 36 months. Intervention Subcutaneous denosumab 60 mg (n=734) or placebo (n=734) every 6 months for up to 36 months. Patients were instructed to take supplemental Calcium and vitamin D. Measurements Primary outcome measure: The percentage change from baseline to month 36 in LS, FN, and TH BMD was measured by dual energy x-ray absorptiometry. BMD at the distal 1/3 radius at 36 months was measured in a sub-study of 309 patients. Results and Limitations At 36 months, significantly more patients in the denosumab arm had increases of >3% BMD from baseline at each site studied compared with placebo (LS, 78% vs 17%; TH, 48% vs 6%; FN, 48% vs 13%; distal 1/3 radius, 40% vs 7%). The percentage of denosumab patients with bone loss at all 3 key BMD sites at month 36 was 1%, as opposed to 42% in placebo arm. At 36 months 69% of denosumab-treated patients had BMD increases at all three sites (LS, TH or FN) compared with 8% of placebo-treated patients. Lower baseline BMD was associated with higher magnitude lumbar spine, femoral neck, and total hip BMD responses to denosumab. Conclusions In men with prostate cancer receiving ADT significantly higher BMD response rates were observed with denosumab vs. placebo. Trial Registration This study is registered with Clinical

  2. Crustal structure of the rifted volcanic margins and uplifted plateau of Western Yemen from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Ahmed, Abdulhakim; Tiberi, Christel; Leroy, Sylvie; Stuart, Graham W.; Keir, Derek; Sholan, Jamal; Khanbari, Khaled; Al-Ganad, Ismael; Basuyau, Clémence

    2013-06-01

    We analyse P-wave receiver functions across the western Gulf of Aden and southern Red Sea continental margins in Western Yemen to constrain crustal thickness, internal crustal structure and the bulk seismic velocity characteristics in order to address the role of magmatism, faulting and mechanical crustal thinning during continental breakup. We analyse teleseismic data from 21 stations forming the temporary Young Conjugate Margins Laboratory (YOCMAL) network together with GFZ and Yemeni permanent stations. Analysis of computed receiver functions shows that (1) the thickness of unextended crust on the Yemen plateau is ˜35 km; (2) this thins to ˜22 km in coastal areas and reaches less than 14 km on the Red Sea coast, where presence of a high-velocity lower crust is evident. The average Vp/Vs ratio for the western Yemen Plateau is 1.79, increasing to ˜1.92 near the Red Sea coast and decreasing to 1.68 for those stations located on or near the granitic rocks. Thinning of the crust, and by inference extension, occurs over a ˜130-km-wide transition zone from the Red Sea and Gulf of Aden coasts to the edges of the Yemen plateau. Thinning of continental crust is particularly localized in a <30-km-wide zone near the coastline, spatially co-incident with addition of magmatic underplate to the lower crust, above which on the surface we observe the presence of seaward dipping reflectors (SDRs) and thickened Oligo-Miocene syn-rift basaltic flows. Our results strongly suggest the presence of high-velocity mafic intrusions in the lower crust, which are likely either synrift magmatic intrusion into continental lower crust or alternatively depleted upper mantle underplated to the base of the crust during the eruption of the SDRs. Our results also point towards a regional breakup history in which the onset of rifting was synchronous along the western Gulf of Aden and southern Red Sea volcanic margins followed by a second phase of extension along the Red Sea margin.

  3. Crustal structure of the rifted volcanic margins and uplifted plateau of Western Yemen from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Ahmed, Abdulhakim; Tiberi, Christel; Leroy, Sylvie; Stuart, Graham; Keir, Derek; Sholan, Jamal; Khanbari, Khaled; Al-Ganad, Ismeal; Basuyau, Clemence

    2013-04-01

    We analyse P-wave receiver functions across the western Gulf of Aden and southern Red Sea continental margins in Western Yemen to constrain crustal thickness, internal crustal structure, and bulk seismic velocity characteristics in order to address the role of magmatism, faulting and mechanical crustal thinning during continental breakup. We analyse teleseismic data from 21 stations forming the temporary Young Conjugate Margins Laboratory (YOCMAL) network together with GFZ and Yemeni permanent stations. Analysis of computed receiver functions shows that (1) the thickness of unextended crust on the Yemen plateau is ~35 km; (2) this thins to ~22 km in coastal areas and reaches less than 14 km on the Red Sea coast, where presence of a high velocity lower crust (HVLC) is evident. The average Vp/Vs ratio for the western Yemen Plateau is 1.79, increasing to ~1.92 near the Red Sea coast and decreasing to 1.68 for those stations located on or near the granitic rocks. Thinning of the crust, and by inference extension, occurs over a ~130 km wide transition zone from the Red Sea and Gulf of Aden coasts to the edges of the Yemen plateau. Thinning of continental crust is particularly localized in a <30-km-wide zone near the coastline, spatially co-incident with addition of magmatic underplate to the lower crust, above which at the surface we observe the presence of seaward dipping reflectors (SDRs)_and thickened Oligo-Miocene syn-rift basaltic flows. Our results strongly suggest the presence of high velocity mafic intrusions in the lower crust, which are likely either synrift magmatic intrusion into continental lower-crust or alternatively depleted upper mantle underplated to the base of the crust during the eruption of the SDRs. Our results also point toward a regional breakup history in which the onset of rifting was synchronous along the western Gulf of Aden and southern Red Sea volcanic margins followed by a second phase of extension along the Red Sea margin.

  4. A joint Monte Carlo analysis of seafloor compliance, Rayleigh wave dispersion and receiver functions at ocean bottom seismic stations offshore New Zealand

    NASA Astrophysics Data System (ADS)

    Ball, Justin S.; Sheehan, Anne F.; Stachnik, Joshua C.; Lin, Fan-Chi; Collins, John A.

    2014-12-01

    body-wave imaging techniques such as receiver function analysis can be notoriously difficult to employ on ocean-bottom seismic data due largely to multiple reverberations within the water and low-velocity sediments. In lieu of suppressing this coherently scattered noise in ocean-bottom receiver functions, these site effects can be modeled in conjunction with shear velocity information from seafloor compliance and surface wave dispersion measurements to discern crustal structure. A novel technique to estimate 1-D crustal shear-velocity profiles from these data using Monte Carlo sampling is presented here. We find that seafloor compliance inversions and P-S conversions observed in the receiver functions provide complimentary constraints on sediment velocity and thickness. Incoherent noise in receiver functions from the MOANA ocean bottom seismic experiment limit the accuracy of the practical analysis at crustal scales, but synthetic recovery tests and comparison with independent unconstrained nonlinear optimization results affirm the utility of this technique in principle.

  5. Instrumental Analysis of Biodiesel Content in Commercial Diesel Blends: An Experiment for Undergraduate Analytical Chemistry

    ERIC Educational Resources Information Center

    Feng, Z. Vivian; Buchman, Joseph T.

    2012-01-01

    The potential of replacing petroleum fuels with renewable biofuels has drawn significant public interest. Many states have imposed biodiesel mandates or incentives to use commercial biodiesel blends. We present an inquiry-driven experiment where students are given the tasks to gather samples, develop analytical methods using various instrumental…

  6. Publication Bias in Studies of an Applied Behavior-Analytic Intervention: An Initial Analysis

    ERIC Educational Resources Information Center

    Sham, Elyssa; Smith, Tristram

    2014-01-01

    Publication bias arises when studies with favorable results are more likely to be reported than are studies with null findings. If this bias occurs in studies with single-subject experimental designs (SSEDs) on applied behavior-analytic (ABA) interventions, it could lead to exaggerated estimates of intervention effects. Therefore, we conducted an…

  7. Effect of Creative Drama on Academic Achievement: A Meta-Analytic and Thematic Analysis

    ERIC Educational Resources Information Center

    Batdi, Veli; Batdi, Hacer

    2015-01-01

    The aim of this study was to determine the effect of creative drama on achievement through the use of quantitative and qualitative research methods. In the quantitative section of the research, the meta-analytic method was used and an attempt was made to include all studies of creative drama carried out between 2000 and 2014 at the national and…

  8. Analytic models of ducted turbomachinery tone noise sources. Volume 1: Analysis

    NASA Technical Reports Server (NTRS)

    Clark, T. L.; Ganz, U. W.; Graf, G. A.; Westall, J. S.

    1974-01-01

    The analytic models developed for computing the periodic sound pressure of subsonic fans and compressors in an infinite, hardwall annular duct with uniform flow are described. The basic sound-generating mechanism is the scattering into sound waves of velocity disturbances appearing to the rotor or stator blades as a series of harmonic gusts. The models include component interactions and rotor alone.

  9. Classification of a target analyte in solid mixtures using principal component analysis, support vector machines, and Raman spectroscopy

    NASA Astrophysics Data System (ADS)

    O'Connell, Marie-Louise; Howley, Tom; Ryder, Alan G.; Leger, Marc N.; Madden, Michael G.

    2005-06-01

    The quantitative analysis of illicit materials using Raman spectroscopy is of widespread interest for law enforcement and healthcare applications. One of the difficulties faced when analysing illicit mixtures is the fact that the narcotic can be mixed with many different cutting agents. This obviously complicates the development of quantitative analytical methods. In this work we demonstrate some preliminary efforts to try and account for the wide variety of potential cutting agents, by discrimination between the target substance and a wide range of excipients. Near-infrared Raman spectroscopy (785 nm excitation) was employed to analyse 217 samples, a number of them consisting of a target analyte (acetaminophen) mixed with excipients of different concentrations by weight. The excipients used were sugars (maltose, glucose, lactose, sorbitol), inorganic materials (talcum powder, sodium bicarbonate, magnesium sulphate), and food products (caffeine, flour). The spectral data collected was subjected to a number of pre-treatment statistical methods including first derivative and normalisation transformations, to make the data more suitable for analysis. Various methods were then used to discriminate the target analytes, these included Principal Component Analysis (PCA), Principal Component Regression (PCR) and Support Vector Machines.

  10. Determination and analysis of an analytical potential for ions in excited configurations in plasmas

    NASA Astrophysics Data System (ADS)

    Rodriguez Perez, Rafael

    The main objective in this Thesis is to propose an analytical expression, within the context of the Independent Particle Model in a central field, for the effective potential that a bound electron feels when it belongs to an ion which is in an excited configuration. It is also an objective that this potential will be obtained as a correction to the effective potential corresponding to the ion in ground state. The potential proposed not only allows to include the effects that the excited configurations introduce on atomic magnitudes but also allows to broach, in a simple and fast way, how to determine the ionic populations and the optical properties of plasmas. The great advantage of the analytical potentials is that they avoid the iterative procedures, which are characteristic in the self-consistent methods, in the calculations of atomic magnitudes and plasma properties. This fact allow a considerable diminution in calculation time. Moreover, the analytical potential proposed in this Thesis has the advantage with respect other analytical potentials that it does not need to fit its parameters when we consider different excited configurations. This fact implies a considerable diminution in the complexity of the problem and in the calculation time and allows to include more excited configurations to model the ions present in the plasma, which improves the results. With the potential proposed in this Thesis we have studied the influence of the excited configurations on atomic magnitudes. Those results have been checked satisfactorily with others obtained by self-consistent methods and by using analytical potentials. We have also used the potential proposed to determine which excited configurations have more probability of presence in a plasma in Local Thermodynamic Equilibrium.

  11. Receiver Design, Performance Analysis, and Evaluation for Space-Borne Laser Altimeters and Space-to-Space Laser Ranging Systems

    NASA Technical Reports Server (NTRS)

    Davidson, Frederic M.; Sun, Xiaoli; Field, Christopher T.

    1996-01-01

    This progress report consists of two separate reports. The first one describes our work on the use of variable gain amplifiers to increase the receiver dynamic range of space borne laser altimeters such as NASA's Geoscience Laser Altimeter Systems (GLAS). The requirement of the receiver dynamic range was first calculated. A breadboard variable gain amplifier circuit was made and the performance was fully characterized. The circuit will also be tested in flight on board the Shuttle Laser Altimeter (SLA-02) next year. The second report describes our research on the master clock oscillator frequency calibration for space borne laser altimeter systems using global positioning system (GPS) receivers.

  12. Teleseismic receiver function analysis in Tierra del Fuego Island: an estimation of crustal thickness and Vp/Vs velocity ratio

    NASA Astrophysics Data System (ADS)

    Buffoni, C.; Sabbione, N. C.; Schimmel, M.; Rosa, M. L.

    2012-04-01

    Tierra del Fuego Island (TdF) is situated in the southern part of South America, where the transform tectonic boundary between the Scotia and South America plates divides the island into two continental blocks. This boundary is represented by a mainly strike-slip lineament known as Magallanes-Fagnano fault system that runs from the western part of the north Scotia ridge to the Chile trench south of 50° S. This fault system is composed of many splays and diverse subparallel faults that overprint the fold-and-thrust belt and are the responsible for the complex tectonic setting that has TdF. Only a few studies have been carried out to constrain the crustal structure and Moho depth in TdF. We present the preliminary estimations on Moho depth and Vp/Vs velocity ratio in TdF Argentinian Island, from teleseismic receiver function analysis with data recorded at five permanent seismic stations. We analyzed data and selected among 40 and 120 events for each seismic station, according to data availability and quality. Earthquakes with magnitudes greater than 5.5 mb and epicentral distances between 30° and 90° were selected. We used Seismic Analysis Code software to pre-process the seismograms. After removing the mean and trend, the data were band-pass filtered using different ranges of frequencies: 0.5-2Hz, 0.08-2Hz and 0.02-1Hz. We applied an iterative deconvolution technique in order to isolate the P-to-S converted waves and obtain the Receiver Functions (RFs). A Gaussian factor of a= 2.5 ( ~1Hz) was selected to reduce the noise and improve the signal coherence in the RFs. Crustal thickness and Vp/Vs ratio were estimated using the H-K stacking method. Since our RFs were not as clear as those typically obtained for simple tectonic settings, we performed different resample techniques to asses the robustness of our results. RFs from clustered events were stacked to increase the signal-to-noise ratio. For this purpose we divided the events into three clusters according event

  13. Analytical determination of orbital elements using Fourier analysis. I. The radial velocity case

    NASA Astrophysics Data System (ADS)

    Delisle, J.-B.; Ségransan, D.; Buchschacher, N.; Alesina, F.

    2016-05-01

    We describe an analytical method for computing the orbital parameters of a planet from the periodogram of a radial velocity signal. The method is very efficient and provides a good approximation of the orbital parameters. The accuracy is mainly limited by the accuracy of the computation of the Fourier decomposition of the signal which is sensitive to sampling and noise. Our method is complementary with more accurate (and more expensive in computer time) numerical algorithms (e.g. Levenberg-Marquardt, Markov chain Monte Carlo, genetic algorithms). Indeed, the analytical approximation can be used as an initial condition to accelerate the convergence of these numerical methods. Our method can be applied iteratively to search for multiple planets in the same system.

  14. A micro-process analysis of Functional Analytic Psychotherapy's mechanism of change.

    PubMed

    Busch, Andrew M; Kanter, Jonathan W; Callaghan, Glenn M; Baruch, David E; Weeks, Cristal E; Berlin, Kristoffer S

    2009-09-01

    This study sought to clarify the micro-process of Functional Analytic Psychotherapy (FAP) by using the Functional Analytic Psychotherapy Rating Scale (FAPRS) to code every client and therapist turn of speech over the course of successful treatment of an individual meeting diagnostic criteria for depression and histrionic personality disorder. Treatment consisted of cognitive behavioral therapy alone followed by the addition of FAP techniques in a unique A / A+B design. In-session client behavior improved following the shift to FAP techniques, and micro-process data suggested that client behavior was effectively shaped by in-vivo FAP procedures. These results support FAP's purported mechanisms of change and highlight the advantages of utilizing molecular coding systems to explore these mechanisms.

  15. Analytical Chemistry with Silica Sol-Gels: Traditional Routes to New Materials for Chemical Analysis

    NASA Astrophysics Data System (ADS)

    Walcarius, Alain; Collinson, Maryanne M.

    2009-07-01

    The versatility of sol-gel chemistry enables us to generate a wide range of silica and organosilica materials with controlled structure, composition, morphology and porosity. These materials’ hosting and recognition properties, as well as their wide-open structures containing many easily accessible active sites, make them particularly attractive for analytical purposes. In this review, we summarize the importance of silica sol-gels in analytical chemistry by providing examples from the separation sciences, optical and electrochemical sensors, molecular imprinting, and biosensors. Recent work suggests that manipulating the structure and composition of these materials at different scales (from molecular to macromolecular states and/or from micro- to meso- and/or macroporous levels) promises to generate chemical and biochemical sensing devices with improved selectivity and sensitivity.

  16. An analytical model accounting for tip shape evolution during atom probe analysis of heterogeneous materials.

    PubMed

    Rolland, N; Larson, D J; Geiser, B P; Duguay, S; Vurpillot, F; Blavette, D

    2015-12-01

    An analytical model describing the field evaporation dynamics of a tip made of a thin layer deposited on a substrate is presented in this paper. The difference in evaporation field between the materials is taken into account in this approach in which the tip shape is modeled at a mesoscopic scale. It was found that the non-existence of sharp edge on the surface is a sufficient condition to derive the morphological evolution during successive evaporation of the layers. This modeling gives an instantaneous and smooth analytical representation of the surface that shows good agreement with finite difference simulations results, and a specific regime of evaporation was highlighted when the substrate is a low evaporation field phase. In addition, the model makes it possible to calculate theoretically the tip analyzed volume, potentially opening up new horizons for atom probe tomographic reconstruction.

  17. IoT Big-Data Centred Knowledge Granule Analytic and Cluster Framework for BI Applications: A Case Base Analysis.

    PubMed

    Chang, Hsien-Tsung; Mishra, Nilamadhab; Lin, Chung-Chih

    2015-01-01

    The current rapid growth of Internet of Things (IoT) in various commercial and non-commercial sectors has led to the deposition of large-scale IoT data, of which the time-critical analytic and clustering of knowledge granules represent highly thought-provoking application possibilities. The objective of the present work is to inspect the structural analysis and clustering of complex knowledge granules in an IoT big-data environment. In this work, we propose a knowledge granule analytic and clustering (KGAC) framework that explores and assembles knowledge granules from IoT big-data arrays for a business intelligence (BI) application. Our work implements neuro-fuzzy analytic architecture rather than a standard fuzzified approach to discover the complex knowledge granules. Furthermore, we implement an enhanced knowledge granule clustering (e-KGC) mechanism that is more elastic than previous techniques when assembling the tactical and explicit complex knowledge granules from IoT big-data arrays. The analysis and discussion presented here show that the proposed framework and mechanism can be implemented to extract knowledge granules from an IoT big-data array in such a way as to present knowledge of strategic value to executives and enable knowledge users to perform further BI actions.

  18. IoT Big-Data Centred Knowledge Granule Analytic and Cluster Framework for BI Applications: A Case Base Analysis

    PubMed Central

    Chang, Hsien-Tsung; Mishra, Nilamadhab; Lin, Chung-Chih

    2015-01-01

    The current rapid growth of Internet of Things (IoT) in various commercial and non-commercial sectors has led to the deposition of large-scale IoT data, of which the time-critical analytic and clustering of knowledge granules represent highly thought-provoking application possibilities. The objective of the present work is to inspect the structural analysis and clustering of complex knowledge granules in an IoT big-data environment. In this work, we propose a knowledge granule analytic and clustering (KGAC) framework that explores and assembles knowledge granules from IoT big-data arrays for a business intelligence (BI) application. Our work implements neuro-fuzzy analytic architecture rather than a standard fuzzified approach to discover the complex knowledge granules. Furthermore, we implement an enhanced knowledge granule clustering (e-KGC) mechanism that is more elastic than previous techniques when assembling the tactical and explicit complex knowledge granules from IoT big-data arrays. The analysis and discussion presented here show that the proposed framework and mechanism can be implemented to extract knowledge granules from an IoT big-data array in such a way as to present knowledge of strategic value to executives and enable knowledge users to perform further BI actions. PMID:26600156

  19. 3D imaging of the Corinth rift from a new passive seismic tomography and receiver function analysis

    NASA Astrophysics Data System (ADS)

    Godano, Maxime; Gesret, Alexandrine; Noble, Mark; Lyon-Caen, Hélène; Gautier, Stéphanie; Deschamps, Anne

    2016-04-01

    model and earthquake location. In addition to the tomographic imaging, we perform a preliminary receiver function analysis of teleseismic data recorded by the broadband stations of the CRL network. The RF analysis should provide the interface depths beneath seismometers and increase the imaging resolution of the upper crustal structures provided by the 3D tomography. In this first attempt, we adjust the 1D velocity model that produces a synthetic RF as similar as possible to the observed RF for a subset of data. We compare the identified interfaces with structures imaged by the tomography.

  20. A semi-automated method for the detection of seismic anisotropy at depth via receiver function analysis

    NASA Astrophysics Data System (ADS)

    Licciardi, A.; Piana Agostinetti, N.

    2016-06-01

    Information about seismic anisotropy is embedded in the variation of the amplitude of the Ps pulses as a function of the azimuth, on both the Radial and the Transverse components of teleseismic receiver functions (RF). We develop a semi-automatic method to constrain the presence and the depth of anisotropic layers beneath a single seismic broad-band station. An algorithm is specifically designed to avoid trial and error methods and subjective crustal parametrizations in RF inversions, providing a suitable tool for large-size data set analysis. The algorithm couples together information extracted from a 1-D VS profile and from a harmonic decomposition analysis of the RF data set. This information is used to determine the number of anisotropic layers and their approximate position at depth, which, in turn, can be used to, for example, narrow the search boundaries for layer thickness and S-wave velocity in a subsequent parameter space search. Here, the output of the algorithm is used to invert an RF data set by means of the Neighbourhood Algorithm (NA). To test our methodology, we apply the algorithm to both synthetic and observed data. We make use of synthetic RF with correlated Gaussian noise to investigate the resolution power for multiple and thin (1-3 km) anisotropic layers in the crust. The algorithm successfully identifies the number and position of anisotropic layers at depth prior the NA inversion step. In the NA inversion, strength of anisotropy and orientation of the symmetry axis are correctly retrieved. Then, the method is applied to field measurement from station BUDO in the Tibetan Plateau. Two consecutive layers of anisotropy are automatically identified with our method in the first 25-30 km of the crust. The data are then inverted with the retrieved parametrization. The direction of the anisotropic axis in the uppermost layer correlates well with the orientation of the major planar structure in the area. The deeper anisotropic layer is associated with

  1. Analytical and numerical analysis of frictional damage in quasi brittle materials

    NASA Astrophysics Data System (ADS)

    Zhu, Q. Z.; Zhao, L. Y.; Shao, J. F.

    2016-07-01

    Frictional sliding and crack growth are two main dissipation processes in quasi brittle materials. The frictional sliding along closed cracks is the origin of macroscopic plastic deformation while the crack growth induces a material damage. The main difficulty of modeling is to consider the inherent coupling between these two processes. Various models and associated numerical algorithms have been proposed. But there are so far no analytical solutions even for simple loading paths for the validation of such algorithms. In this paper, we first present a micro-mechanical model taking into account the damage-friction coupling for a large class of quasi brittle materials. The model is formulated by combining a linear homogenization procedure with the Mori-Tanaka scheme and the irreversible thermodynamics framework. As an original contribution, a series of analytical solutions of stress-strain relations are developed for various loading paths. Based on the micro-mechanical model, two numerical integration algorithms are exploited. The first one involves a coupled friction/damage correction scheme, which is consistent with the coupling nature of the constitutive model. The second one contains a friction/damage decoupling scheme with two consecutive steps: the friction correction followed by the damage correction. With the analytical solutions as reference results, the two algorithms are assessed through a series of numerical tests. It is found that the decoupling correction scheme is efficient to guarantee a systematic numerical convergence.

  2. Analysis of plant gums and saccharide materials in paint samples: comparison of GC-MS analytical procedures and databases

    PubMed Central

    2012-01-01

    Background Saccharide materials have been used for centuries as binding media, to paint, write and illuminate manuscripts and to apply metallic leaf decorations. Although the technical literature often reports on the use of plant gums as binders, actually several other saccharide materials can be encountered in paint samples, not only as major binders, but also as additives. In the literature, there are a variety of analytical procedures that utilize GC-MS to characterize saccharide materials in paint samples, however the chromatographic profiles are often extremely different and it is impossible to compare them and reliably identify the paint binder. Results This paper presents a comparison between two different analytical procedures based on GC-MS for the analysis of saccharide materials in works-of-art. The research presented here evaluates the influence of the analytical procedure used, and how it impacts the sugar profiles obtained from the analysis of paint samples that contain saccharide materials. The procedures have been developed, optimised and systematically used to characterise plant gums at the Getty Conservation Institute in Los Angeles, USA (GCI) and the Department of Chemistry and Industrial Chemistry of the University of Pisa, Italy (DCCI). The main steps of the analytical procedures and their optimisation are discussed. Conclusions The results presented highlight that the two methods give comparable sugar profiles, whether the samples analysed are simple raw materials, pigmented and unpigmented paint replicas, or paint samples collected from hundreds of centuries old polychrome art objects. A common database of sugar profiles of reference materials commonly found in paint samples was thus compiled. The database presents data also from those materials that only contain a minor saccharide fraction. This database highlights how many sources of saccharides can be found in a paint sample, representing an important step forward in the problem of

  3. The application of multiple analyte adduct formation in the LC-MS(3) analysis of valproic acid in human serum.

    PubMed

    Dziadosz, Marek

    2017-01-01

    LC-MS using electrospray ionisation (negative ion mode) and low-energy collision-induced dissociation tandem mass spectrometric (CID-MS/MS) analysis, together with the multiple analyte adduct formation with the components of the mobile phase, were applied to analyse valproic acid in human serum with LC-MS(3). The CID-fragmentation of the precursor analyte adduct [M+2CH3COONa-H](-) was applied in the method validation (307.1/225.1/143.0). Chromatographic separation was performed with a Luna 5μm C18 (2) 100A, 150mm×2mm column and the elution with a mobile phase consisting of A (H2O/methanol=95/5, v/v) and B (H2O/methanol=3/97, v/v), both with 10mM ammonium acetate and 0.1% acetic acid. A binary flow pumping mode with a total flow rate of 0.400mL/min was used. The calculated limit of detection/quantification of the method calibrated in the range of 10-200μg/mL was 0.31/1.0μg/mL. The sample preparation based on protein precipitation with 1mL of H2O/methanol solution (3/97, v/v) with 10mM sodium acetate and 100mM acetic acid. On the basis of the experiments performed could be demonstrated, that multiple analyte adduct formation can be applied to generate MS(3) quantitation of analytes with problematic fragmentation. The presented new strategy makes the analysis of small drugs, which do not produce any stable product ions at all, on the basis of LC-MS(3) possible.

  4. Eliciting and Receiving Online Support: Using Computer-Aided Content Analysis to Examine the Dynamics of Online Social Support

    PubMed Central

    Kraut, Robert E; Levine, John M

    2015-01-01

    Background Although many people with serious diseases participate in online support communities, little research has investigated how participants elicit and provide social support on these sites. Objective The first goal was to propose and test a model of the dynamic process through which participants in online support communities elicit and provide emotional and informational support. The second was to demonstrate the value of computer coding of conversational data using machine learning techniques (1) by replicating results derived from human-coded data about how people elicit support and (2) by answering questions that are intractable with small samples of human-coded data, namely how exposure to different types of social support predicts continued participation in online support communities. The third was to provide a detailed description of these machine learning techniques to enable other researchers to perform large-scale data analysis in these communities. Methods Communication among approximately 90,000 registered users of an online cancer support community was analyzed. The corpus comprised 1,562,459 messages organized into 68,158 discussion threads. Amazon Mechanical Turk workers coded (1) 1000 thread-starting messages on 5 attributes (positive and negative emotional self-disclosure, positive and negative informational self-disclosure, questions) and (2) 1000 replies on emotional and informational support. Their judgments were used to train machine learning models that automatically estimated the amount of these 7 attributes in the messages. Across attributes, the average Pearson correlation between human-based judgments and computer-based judgments was .65. Results Part 1 used human-coded data to investigate relationships between (1) 4 kinds of self-disclosure and question asking in thread-starting posts and (2) the amount of emotional and informational support in the first reply. Self-disclosure about negative emotions (beta=.24, P<.001), negative

  5. Image analysis for a microfluidic paper-based analytical device using the CIE L*a*b* color system.

    PubMed

    Komatsu, Takeshi; Mohammadi, Saeed; Busa, Lori Shayne Alamo; Maeki, Masatoshi; Ishida, Akihiko; Tani, Hirofumi; Tokeshi, Manabu

    2016-11-28

    The combination of a microfluidic paper-based analytical device (μPAD) and digital image analysis is widely used for quantitative analysis with μPADs because of its easy and simple operation. Herein, we have demonstrated a quantitative analysis based on multiple color changes on a μPAD. The CIE L*a*b* color system was employed to analyse the digital images obtained with the μPAD. We made pH measurements using a universal pH-indicator showing multiple color changes for various pH values of aqueous test solutions. The detectable pH range of this method was wider than the typical grayscale-based image analysis, and we succeeded in the measurements for a wide pH range of 2-9.

  6. The Five Planets in the Kepler-296 Binary System All Orbit the Primary: A Statistical and Analytical Analysis

    NASA Astrophysics Data System (ADS)

    Barclay, Thomas; Quintana, Elisa V.; Adams, Fred C.; Ciardi, David R.; Huber, Daniel; Foreman-Mackey, Daniel; Montet, Benjamin T.; Caldwell, Douglas

    2015-08-01

    Kepler-296 is a binary star system with two M-dwarf components separated by 0.″2. Five transiting planets have been confirmed to be associated with the Kepler-296 system; given the evidence to date, however, the planets could in principle orbit either star. This ambiguity has made it difficult to constrain both the orbital and physical properties of the planets. Using both statistical and analytical arguments, this paper shows that all five planets are highly likely to orbit the primary star in this system. We performed a Markov-Chain Monte Carlo simulation using a five transiting planet model, leaving the stellar density and dilution with uniform priors. Using importance sampling, we compared the model probabilities under the priors of the planets orbiting either the brighter or the fainter component of the binary. A model where the planets orbit the brighter component, Kepler-296A, is strongly preferred by the data. Combined with our assertion that all five planets orbit the same star, the two outer planets in the system, Kepler-296 Ae and Kepler-296 Af, have radii of 1.53 ± 0.26 and 1.80 ± 0.31 {R}\\oplus , respectively, and receive incident stellar fluxes of 1.40 ± 0.23 and 0.62 ± 0.10 times the incident flux the Earth receives from the Sun. This level of irradiation places both planets within or close to the circumstellar habitable zone of their parent star.

  7. Receiver design, performance analysis, and evaluation for space-borne laser altimeters and space-to-space laser ranging systems

    NASA Technical Reports Server (NTRS)

    Davidson, Frederic M.; Sun, Xiaoli; Field, Christopher T.

    1995-01-01

    Laser altimeters measure the time of flight of the laser pulses to determine the range of the target. The simplest altimeter receiver consists of a photodetector followed by a leading edge detector. A time interval unit (TIU) measures the time from the transmitted laser pulse to the leading edge of the received pulse as it crosses a preset threshold. However, the ranging error of this simple detection scheme depends on the received, pulse amplitude, pulse shape, and the threshold. In practice, the pulse shape and the amplitude are determined by the target target characteristics which has to be assumed unknown prior to the measurement. The ranging error can be improved if one also measures the pulse width and use the average of the leading and trailing edges (half pulse width) as the pulse arrival time. The ranging error becomes independent of the received pulse amplitude and the pulse width as long as the pulse shape is symmetric. The pulse width also gives the slope of the target. The ultimate detection scheme is to digitize the received waveform and calculate the centroid as the pulse arrival time. The centroid detection always gives unbiased measurement even for asymmetric pulses. In this report, we analyze the laser altimeter ranging errors for these three detection schemes using the Mars Orbital Laser Altimeter (MOLA) as an example.

  8. Performance outlook of the SCRAP receiver

    NASA Astrophysics Data System (ADS)

    Lubkoll, Matti; von Backström, Theodor W.; Harms, Thomas M.

    2016-05-01

    A combined cycle (CC) concentrating solar power (CSP) plant provides significant potential to achieve an efficiency increase and an electricity cost reduction compared to current single-cycle plants. A CC CSP system requires a receiver technology capable of effectively transferring heat from concentrated solar irradiation to a pressurized air stream of a gas turbine. The small number of pressurized air receivers demonstrated to date have practical limitations, when operating at high temperatures and pressures. As yet, a robust, scalable and efficient system has to be developed and commercialized. A novel receiver system, the Spiky Central Receiver Air Pre-heater (SCRAP) concept has been proposed to comply with these requirements. The SCRAP system is conceived as a solution for an efficient and robust pressurized air receiver that could be implemented in CC CSP concepts or standalone solar Brayton cycles without a bottoming Rankine cycle. The presented work expands on previous publications on the thermal modeling of the receiver system. Based on the analysis of a single heat transfer element (spike), predictions for its thermal performance can be made. To this end the existing thermal model was improved by heat transfer characteristics for the jet impingement region of the spike tip as well as heat transfer models simulating the interaction with ambient. While the jet impingement cooling effect was simulated employing a commercial CFD code, the ambient heat transfer model was based on simplifying assumptions in order to employ empirical and analytical equations. The thermal efficiency of a spike under design conditions (flux 1.0 MW/m2, air outlet temperature just below 800 °C) was calculated at approximately 80 %, where convective heat losses account for 16.2 % of the absorbed radiation and radiative heat losses for a lower 2.9 %. This effect is due to peak surface temperatures occurring at the root of the spikes. It can thus be concluded that the geometric

  9. Analytical performance of benchtop total reflection X-ray fluorescence instrumentation for multielemental analysis of wine samples

    NASA Astrophysics Data System (ADS)

    Dalipi, Rogerta; Marguí, Eva; Borgese, Laura; Bilo, Fabjola; Depero, Laura E.

    2016-06-01

    Recent technological improvements have led to a widespread adoption of benchtop total reflection X-ray fluorescence systems (TXRF) for analysis of liquid samples. However, benchtop TXRF systems usually present limited sensitivity compared with high-scale instrumentation which can restrict its application in some fields. The aim of the present work was to evaluate and compare the analytical capabilities of two TXRF systems, equipped with low power Mo and W target X-ray tubes, for multielemental analysis of wine samples. Using the Mo-TXRF system, the detection limits for most elements were one order of magnitude lower than those attained using the W-TXRF system. For the detection of high Z elements like Cd and Ag, however, W-TXRF remains a very good option due to the possibility of K-Lines detection. Accuracy and precision of the obtained results have been evaluated analyzing spiked real wine samples and comparing the TXRF results with those obtained by inductively coupled plasma emission spectroscopy (ICP-OES). In general, good agreement was obtained between ICP-OES and TXRF results for the analysis of both red and white wine samples except for light elements (i.e., K) which TXRF concentrations were underestimated. However, a further achievement of analytical quality of TXRF results can be achieved if wine analysis is performed after dilution of the sample with de-ionized water.

  10. Crustal structure of Tolfa domes complex (northern Latium - Italy) inferred from receiver functions analysis: an interplay between tectonics and magmatism

    NASA Astrophysics Data System (ADS)

    Buttinelli, M.; Bianchi, I.; Anselmi, M.; Chiarabba, C.; de Rita, D.; Quattrocchi, F.

    2010-12-01

    The Tolfa-Cerite volcanic district developed along the Tyrrhenian passive margin of central Italy, as part of magmatic processes started during the middle Pliocene. In this area the uncertainties on the deep crustal structures and the definition of the intrusive bodies geometry are focal issues that still need to be addressed. After the onset of the spreading of the Tyrrhenian sea during the Late Miocene, the emplacement of the intrusive bodies of the Tolfa complex (TDC), in a general back-arc geodynamical regime, generally occurred in a low stretching rate, in correspondence of the junctions between major lithospheric discontinuities. Normal faults, located at the edge of Mio-Pliocene basins, were used as preferential pathways for the rising of magmatic masses from the mantle to the surface. We used teleseismic recordings at the TOLF and MAON broad band station of the INGV seismic network (located between the Argentario promontory and Tolfa-Ceriti dome complexes -TDC-) to image the principal seismic velocity discontinuities by receiver function analysis (RF's). Together with RF’s velocity models of the area computed using the teleseismic events recorded by a temporary network of eight stations deployed around the TDC, we achieve a general crustal model of this area. The geometry of the seismic network has been defined to focus on the crustal structure beneath the TDC, trying to define the main velocity changes attributable to the intrusive bodies, the calcareous basal complex, the deep metamorphic basement, the lower crust and the Moho. The analysis of these data show the Moho at a depth of 23 km in the TDC area and 20 km in the Argentario area. Crustal models also show an unexpected velocity decrease between 12 and 18 km, consistent with a slight dropdown of the Vp/Vs ratio, imputable to a regional mid-crustal shear zone inherited from the previous alpine orogenesis, re-activated in extensional tectonic by the early opening phases of the Tyrrhenian sea. Above

  11. Experimental analysis of the pressure drop and heat transfer through metal foams used as volumetric receivers under concentrated solar radiation

    SciTech Connect

    Albanakis, C.; Missirlis, D.; Yakinthos, K.; Goulas, A.; Michailidis, N.; Omar, H.; Tsipas, D.; Granier, B.

    2009-01-15

    The main objective of this work was to evaluate the behavior of porous materials, when treated as volumetric receivers under concentrated solar radiation. For this reason various porous metallic and ceramic materials have been tested as potential receivers for concentrated solar radiation. The experimental investigation showed that their efficiency was depending on both materials parameters and flow conditions. In this work, a variety of foam materials such as Ni and Ni alloy, inconel, copper, aluminum and SiC with different open cell porosity were tested as potential media to be used as volumetric receivers and heat exchangers. However, since the results were similar, for space economy, only the results of two of them, nickel and inconel were presented in detail and compared with each other. (author)

  12. Metagenomic analysis of bacterial community composition and antibiotic resistance genes in a wastewater treatment plant and its receiving surface water.

    PubMed

    Tang, Junying; Bu, Yuanqing; Zhang, Xu-Xiang; Huang, Kailong; He, Xiwei; Ye, Lin; Shan, Zhengjun; Ren, Hongqiang

    2016-10-01

    The presence of pathogenic bacteria and the dissemination of antibiotic resistance genes (ARGs) may pose big risks to the rivers that receive the effluent from municipal wastewater treatment plants (WWTPs). In this study, we investigated the changes of bacterial community and ARGs along treatment processes of one WWTP, and examined the effects of the effluent discharge on the bacterial community and ARGs in the receiving river. Pyrosequencing was applied to reveal bacterial community composition including potential bacterial pathogen, and Illumina high-throughput sequencing was used for profiling ARGs. The results showed that the WWTP had good removal efficiency on potential pathogenic bacteria (especially Arcobacter butzleri) and ARGs. Moreover, the bacterial communities of downstream and upstream of the river showed no significant difference. However, the increase in the abundance of potential pathogens and ARGs at effluent outfall was observed, indicating that WWTP effluent might contribute to the dissemination of potential pathogenic bacteria and ARGs in the receiving river.

  13. Analytical modeling and tolerance analysis of a linear variable filter for spectral order sorting.

    PubMed

    Ko, Cheng-Hao; Chang, Kuei-Ying; Huang, You-Min

    2015-02-23

    This paper proposes an innovative method to overcome the low production rate of current linear variable filter (LVF) fabrication. During the fabrication process, a commercial coater is combined with a local mask on a substrate. The proposed analytical thin film thickness model, which is based on the geometry of the commercial coater, is developed to more effectively calculate the profiles of LVFs. Thickness tolerance, LVF zone width, thin film layer structure, transmission spectrum and the effects of variations in critical parameters of the coater are analyzed. Profile measurements demonstrate the efficacy of local mask theory in the prediction of evaporation profiles with a high degree of accuracy.

  14. Analytical analysis of a beam flexural-mode piezoelectric actuator for deformable mirrors

    NASA Astrophysics Data System (ADS)

    Wang, Hairen

    2015-10-01

    A beam flexural-mode piezoelectric bimorph actuator is analyzed based on linear piezoelectricity, and the performance of the actuator is studied. The beam bimorph piezoelectric actuator (BBPA), which is a sandwich compound consisting of a lower and an upper piezoelectric ceramic surface layer and a middle layer made of metal, is driven to flexural deformation. The statistical analytical solution and dynamical solutions from the three-dimensional equations of linear piezoelectricity are derived, and the dependence of the performance upon the physical parameters of the BBPA is evaluated. Numerical results illustrate the strengthened performance achieved by adjusting the geometrical and material parameters of the BBPA.

  15. Asymptotic BER analysis of FSO with multiple receive apertures over ℳ -distributed turbulence channels with pointing errors.

    PubMed

    Yang, Liang; Hasna, Mazen Omar; Gao, Xiqi

    2014-07-28

    In this paper, we consider a free-space optical (FSO) communication with multiple receive apertures over ℳ -distributed turbulence channels with pointing errors. In particular, we consider two different combining schemes at the receiver: optimal combining (OC) and selection combining (SC). With these setups, the statistic characters of the instantaneous electrical signal-to-noise ratio (SNR) are derived. Then, using the cumulative density function (CDF)-based method, we analyze the asymptotic bit-error rate (BER) performance. The derived results help quantifying the diversity order of our considered systems.

  16. Using Fuzzy Analytic Hierarchy Process multicriteria and Geographical information system for coastal vulnerability analysis in Morocco: The case of Mohammedia

    NASA Astrophysics Data System (ADS)

    Tahri, Meryem; Maanan, Mohamed; Hakdaoui, Mustapha

    2016-04-01

    This paper shows a method to assess the vulnerability of coastal risks such as coastal erosion or submarine applying Fuzzy Analytic Hierarchy Process (FAHP) and spatial analysis techniques with Geographic Information System (GIS). The coast of the Mohammedia located in Morocco was chosen as the study site to implement and validate the proposed framework by applying a GIS-FAHP based methodology. The coastal risk vulnerability mapping follows multi-parametric causative factors as sea level rise, significant wave height, tidal range, coastal erosion, elevation, geomorphology and distance to an urban area. The Fuzzy Analytic Hierarchy Process methodology enables the calculation of corresponding criteria weights. The result shows that the coastline of the Mohammedia is characterized by a moderate, high and very high level of vulnerability to coastal risk. The high vulnerability areas are situated in the east at Monika and Sablette beaches. This technical approach is based on the efficiency of the Geographic Information System tool based on Fuzzy Analytical Hierarchy Process to help decision maker to find optimal strategies to minimize coastal risks.

  17. Analytical model for Transient Current Technique (TCT) signal prediction and analysis for thin interface characterization

    NASA Astrophysics Data System (ADS)

    Bronuzzi, J.; Mapelli, A.; Sallese, J. M.

    2016-12-01

    A silicon wafer bonding technique has been recently proposed for the fabrication of monolithic silicon radiation detectors. This new process would enable direct bonding of a read-out electronic chip wafer on a highly resistive silicon substrate wafer. Therefore, monolithic silicon detectors could be fabricated in this way which would allow the free choice of electronic chips and high resistive silicon bulk, even from different providers. Moreover, a monolithic detector with a high resistive bulk would also be available. Electrical properties of the bonded interface are then critical for this application. Indeed, mobile charges generated by radiation inside the bonded bulk are expected to transit through the interface to be collected by the read-out electronics. In order to characterize this interface, the concept of Transient Current Technique (TCT) has been explored by means of numerical simulations combined with a physics based analytical model. In this work, the analytical model giving insight into the physics behind the TCT dependence upon interface traps is validated using both TCAD simulations and experimental measurements.

  18. Analysis of low molecular weight metabolites in tea using mass spectrometry-based analytical methods.

    PubMed

    Fraser, Karl; Harrison, Scott J; Lane, Geoff A; Otter, Don E; Hemar, Yacine; Quek, Siew-Young; Rasmussen, Susanne

    2014-01-01

    Tea is the second most consumed beverage in the world after water and there are numerous reported health benefits as a result of consuming tea, such as reducing the risk of cardiovascular disease and many types of cancer. Thus, there is much interest in the chemical composition of teas, for example; defining components responsible for contributing to reported health benefits; defining quality characteristics such as product flavor; and monitoring for pesticide residues to comply with food safety import/export requirements. Covered in this review are some of the latest developments in mass spectrometry-based analytical techniques for measuring and characterizing low molecular weight components of tea, in particular primary and secondary metabolites. The methodology; more specifically the chromatography and detection mechanisms used in both targeted and non-targeted studies, and their main advantages and disadvantages are discussed. Finally, we comment on the latest techniques that are likely to have significant benefit to analysts in the future, not merely in the area of tea research, but in the analytical chemistry of low molecular weight compounds in general.

  19. A Statistical Comparison of the Blossom Blight Forecasts of MARYBLYT and Cougarblight with Receiver Operating Characteristic Curve Analysis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Blossom blight forecasting is an important aspect of fire blight, caused by Erwinia amylovora, management for both apple and pear. A comparison of the forecast accuracy of two common fire blight forecasters, MARYBLYT and Cougarblight, was performed with receiver operating characteristic (ROC) curve ...

  20. The Obsessive Compulsive Scale of the Child Behavior Checklist Predicts Obsessive-Compulsive Disorder: A Receiver Operating Characteristic Curve Analysis

    ERIC Educational Resources Information Center

    Hudziak, James J.; Althoff, Robert R.; Stanger, Catherine; van Beijsterveldt, C. E. M.; Nelson, Elliot C.; Hanna, Gregory L.; Boomsma, Dorret I.; Todd, Richard D.

    2006-01-01

    Background: The purpose of this study was to determine a score on the Obsessive Compulsive Scale (OCS) from the Child Behavior Checklist (CBCL) to screen for obsessive compulsive disorder (OCD) in children and to rigorously test the specificity and sensitivity of a single cutpoint. Methods: A receiver operating characteristic (ROC) curve analysis…

  1. A REVISED SOLAR TRANSFORMITY FOR TIDAL ENERGY RECEIVED BY THE EARTH AND DISSIPATED GLOBALLY: IMPLICATIONS FOR EMERGY ANALYSIS

    EPA Science Inventory

    Solar transformities for the tidal energy received by the earth and the tidal energy dissipated globally can be calculated because both solar energy and the gravitational attraction of the sun and moon drive independent processes that produce an annual flux of geopotential energy...

  2. An Analysis of Vocational Rehabilitation Services for Consumers with Hearing Impairments Who Received College or University Training

    ERIC Educational Resources Information Center

    Boutin, Daniel L.; Wilson, Keith

    2009-01-01

    The purpose of this study was to determine the predictive ability of vocational rehabilitation services for deaf and hard of hearing consumers who received college and university training. The RSA-911 database for fiscal year 2004 was analyzed to evaluate the effectiveness of 21 services in leading to competitive employment. A model predicting…

  3. An Investigation of the Relationship between the Fear of Receiving Negative Criticism and of Taking Academic Risk through Canonical Correlation Analysis

    ERIC Educational Resources Information Center

    Cetin, Bayram; Ilhan, Mustafa; Yilmaz, Ferat

    2014-01-01

    The aim of this study is to examine the relationship between the fear of receiving negative criticism and taking academic risk through canonical correlation analysis-in which a relational model was used. The participants of the study consisted of 215 university students enrolled in various programs at Dicle University's Ziya Gökalp Faculty of…

  4. Analysis of accuracy of approximate, simultaneous, nonlinear confidence intervals on hydraulic heads in analytical and numerical test cases

    USGS Publications Warehouse

    Hill, M.C.

    1989-01-01

    Inaccuracies in parameter values, parameterization, stresses, and boundary conditions of analytical solutions and numerical models of groundwater flow produce errors in simulated hydraulic heads. These errors can be quantified in terms of approximate, simultaneous, nonlinear confidence intervals presented in the literature. Approximate confidence intervals can be applied in both error and sensitivity analysis and can be used prior to calibration or when calibration was accomplished by trial and error. The method is expanded for use in numerical problems, and the accuracy of the approximate intervals is evaluated using Monte Carlo runs. Four test cases are reported. -from Author

  5. Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies.

    PubMed

    Chen, Hui; Luthra, Rajyalakshmi; Goswami, Rashmi S; Singh, Rajesh R; Roy-Chowdhuri, Sinchita

    2015-08-28

    Application of next-generation sequencing (NGS) technology to routine clinical practice has enabled characterization of personalized cancer genomes to identify patients likely to have a response to targeted therapy. The proper selection of tumor sample for downstream NGS based mutational analysis is critical to generate accurate results and to guide therapeutic intervention. However, multiple pre-analytic factors come into play in determining the success of NGS testing. In this review, we discuss pre-analytic requirements for AmpliSeq PCR-based sequencing using Ion Torrent Personal Genome Machine (PGM) (Life Technologies), a NGS sequencing platform that is often used by clinical laboratories for sequencing solid tumors because of its low input DNA requirement from formalin fixed and paraffin embedded tissue. The success of NGS mutational analysis is affected not only by the input DNA quantity but also by several other factors, including the specimen type, the DNA quality, and the tumor cellularity. Here, we review tissue requirements for solid tumor NGS based mutational analysis, including procedure types, tissue types, tumor volume and fraction, decalcification, and treatment effects.

  6. Exploiting green analytical procedures for acidity and iron assays employing flow analysis with simple natural reagent extracts.

    PubMed

    Grudpan, Kate; Hartwell, Supaporn Kradtap; Wongwilai, Wasin; Grudpan, Supara; Lapanantnoppakhun, Somchai

    2011-06-15

    Green analytical methods employing flow analysis with simple natural reagent extracts have been exploited. Various formats of flow based analysis systems including a single line FIA, a simple lab on chip with webcam camera detector, and a newly developed simple lab on chip system with reflective absorption detection and the simple extracts from some available local plants including butterfly pea flower, orchid flower, and beet root were investigated and shown to be useful as alternative self indicator reagents for acidity assay. Various tea drinks were explored to be used for chromogenic reagents in iron determination. The benefit of a flow based system, which allows standards and samples to go through the analysis process in exactly the same conditions, makes it possible to employ simple natural extracts with minimal or no pretreatment or purification. The combinations of non-synthetic natural reagents with minimal processed extracts and the low volume requirement flow based systems create some unique green chemical analyses.

  7. Validating Analytical Methods

    ERIC Educational Resources Information Center

    Ember, Lois R.

    1977-01-01

    The procedures utilized by the Association of Official Analytical Chemists (AOAC) to develop, evaluate, and validate analytical methods for the analysis of chemical pollutants are detailed. Methods validated by AOAC are used by the EPA and FDA in their enforcement programs and are granted preferential treatment by the courts. (BT)

  8. Optimization in the design of a 12 gigahertz low cost ground receiving system for broadcast satellites. Volume 1: System design, performance, and cost analysis

    NASA Technical Reports Server (NTRS)

    Ohkubo, K.; Han, C. C.; Albernaz, J.; Janky, J. M.; Lusignan, B. B.

    1972-01-01

    The technical and economical feasibility of using the 12 GHz band for broadcasting from satellites were examined. Among the assigned frequency bands for broadcast satellites, the 12 GHz band system offers the most channels. It also has the least interference on and from the terrestrial communication links. The system design and analysis are carried out on the basis of a decision analysis model. Technical difficulties in achieving low-cost 12 GHz ground receivers are solved by making use of a die cast aluminum packaging, a hybrid integrated circuit mixer, a cavity stabilized Gunn oscillator and other state-of-the-art microwave technologies for the receiver front-end. A working model was designed and tested, which used frequency modulation. A final design for the 2.6 GHz system ground receiver is also presented. The cost of the ground-terminal was analyzed and minimized for a given figure-of-merit (a ratio of receiving antenna gain to receiver system noise temperature). The results were used to analyze the performance and cost of the whole satellite system.

  9. Analytic materials

    NASA Astrophysics Data System (ADS)

    Milton, Graeme W.

    2016-11-01

    The theory of inhomogeneous analytic materials is developed. These are materials where the coefficients entering the equations involve analytic functions. Three types of analytic materials are identified. The first two types involve an integer p. If p takes its maximum value, then we have a complete analytic material. Otherwise, it is incomplete analytic material of rank p. For two-dimensional materials, further progress can be made in the identification of analytic materials by using the well-known fact that a 90° rotation applied to a divergence-free field in a simply connected domain yields a curl-free field, and this can then be expressed as the gradient of a potential. Other exact results for the fields in inhomogeneous media are reviewed. Also reviewed is the subject of metamaterials, as these materials provide a way of realizing desirable coefficients in the equations.

  10. Analytic materials.

    PubMed

    Milton, Graeme W

    2016-11-01

    The theory of inhomogeneous analytic materials is developed. These are materials where the coefficients entering the equations involve analytic functions. Three types of analytic materials are identified. The first two types involve an integer p. If p takes its maximum value, then we have a complete analytic material. Otherwise, it is incomplete analytic material of rank p. For two-dimensional materials, further progress can be made in the identification of analytic materials by using the well-known fact that a 90(°) rotation applied to a divergence-free field in a simply connected domain yields a curl-free field, and this can then be expressed as the gradient of a potential. Other exact results for the fields in inhomogeneous media are reviewed. Also reviewed is the subject of metamaterials, as these materials provide a way of realizing desirable coefficients in the equations.

  11. Some Comments on Analytic Traditions in EFA As against CFA: An Analysis of Selected Research Reports.

    ERIC Educational Resources Information Center

    Kieffer, Kevin M.

    Factor analysis has historically been used for myriad purposes in the social and behavioral sciences, but an especially important application of this technique has been to evaluate construct validity. Since in the present milieu both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) are readily available to the researcher,…

  12. Publication bias in studies of an applied behavior-analytic intervention: an initial analysis.

    PubMed

    Sham, Elyssa; Smith, Tristram

    2014-01-01

    Publication bias arises when studies with favorable results are more likely to be reported than are studies with null findings. If this bias occurs in studies with single-subject experimental designs(SSEDs) on applied behavior-analytic (ABA) interventions, it could lead to exaggerated estimates of intervention effects. Therefore, we conducted an initial test of bias by comparing effect sizes, measured by percentage of nonoverlapping data (PND), in published SSED studies (n=21) and unpublished dissertations (n=10) on 1 well-established intervention for children with autism, pivotal response treatment (PRT). Although published and unpublished studies had similar methodologies, the mean PND in published studies was 22% higher than in unpublished studies, 95% confidence interval (4%, 38%). Even when unpublished studies are included, PRT appeared to be effective (PNDM=62%). Nevertheless, the disparity between published and unpublished studies suggests a need for further assessment of publication bias in the ABA literature.

  13. Numerical stability analysis of the pseudo-spectral analytical time-domain PIC algorithm

    SciTech Connect

    Godfrey, Brendan B.; Vay, Jean-Luc; Haber, Irving

    2014-02-01

    The pseudo-spectral analytical time-domain (PSATD) particle-in-cell (PIC) algorithm solves the vacuum Maxwell's equations exactly, has no Courant time-step limit (as conventionally defined), and offers substantial flexibility in plasma and particle beam simulations. It is, however, not free of the usual numerical instabilities, including the numerical Cherenkov instability, when applied to relativistic beam simulations. This paper derives and solves the numerical dispersion relation for the PSATD algorithm and compares the results with corresponding behavior of the more conventional pseudo-spectral time-domain (PSTD) and finite difference time-domain (FDTD) algorithms. In general, PSATD offers superior stability properties over a reasonable range of time steps. More importantly, one version of the PSATD algorithm, when combined with digital filtering, is almost completely free of the numerical Cherenkov instability for time steps (scaled to the speed of light) comparable to or smaller than the axial cell size.

  14. Mission Analysis Program for Solar Electric Propulsion (MAPSEP). Volume 1: Analytical manual for earth orbital MAPSEP

    NASA Technical Reports Server (NTRS)

    1975-01-01

    An introduction to the MAPSEP organization and a detailed analytical description of all models and algorithms are given. These include trajectory and error covariance propagation methods, orbit determination processes, thrust modeling, and trajectory correction (guidance) schemes. Earth orbital MAPSEP contains the capability of analyzing almost any currently projected low thrust mission from low earth orbit to super synchronous altitudes. Furthermore, MAPSEP is sufficiently flexible to incorporate extended dynamic models, alternate mission strategies, and almost any other system requirement imposed by the user. As in the interplanetary version, earth orbital MAPSEP represents a trade-off between precision modeling and computational speed consistent with defining necessary system requirements. It can be used in feasibility studies as well as in flight operational support. Pertinent operational constraints are available both implicitly and explicitly. However, the reader should be warned that because of program complexity, MAPSEP is only as good as the user and will quickly succumb to faulty user inputs.

  15. Treaty verification sample analysis program analytical results: UNSCOM 65 samples. Final report, December 1993-January 1994

    SciTech Connect

    Szafraniec, L.L.; Beaudry, W.T.; Bossle, P.C.; Durst, H.D.; Ellzy, M.W.

    1994-07-01

    Nineteen samples from the United Nations Special Commission 65 on Iraq (UNSCOM 65) were analyzed for chemical warfare (CW) related compounds using a variety of highly sophisticated spectroscopic and chromatographic techniques. The samples consisted of six water, six soil, two vegetation, one cloth, one wood, and two mortar shell crosscut sections. No sulfur or nitrogen mustards, Lewsite, or any of their degradation products were detected. No nerve agents were observed, and no tin was detected precluding the presence of stannic chloride, a component of NC, a World War I choking agent. Diethyl phosphoric acid was unambiguously identified in three water samples, and ethyl phosphoric acid was tentatively identified, at very low levels, in one water sample. These phosphoric acids are degradation products of Amiton, many commercially available pesticides, as well as Tabun, and impurities in munitions-grade Tabun. No definitive conclusions concerning the source of these two chemicals could be drawn from the analytical results.

  16. Sensitivity Analysis of Semi-Analytical Models of Diffuse Attenuation of Downwelling Irradiance in Lake Balaton

    NASA Astrophysics Data System (ADS)

    Van der Zande, D.; Blaas, M.; Nechad, B.

    2015-12-01

    A quantification of the available light in the water column is key to evaluate the water quality in lakes as it is one of the major factors determining primary production. The light environment in water is generally described in terms of the vertical attenuation coefficient (Kd) and euphotic depth (Ze) where the light is reduced to 1% of its (just below) surface value. Reliable models to estimate KdPAR (and Ze) from remote sensing measurements have been successfully demonstrated in marine applications using typical ocean colour missions such as MERIS-envisat (300m) and MODIS-AQUA (250-1000m). In this study, we present the adaptation of a semi-analytical model for Kd and Ze, developed for MERIS/MODIS, to the new and upcoming sensors bands for inland water cases.

  17. Analytical and experimental analysis of stress concentration in notched multilayered composites with finite outer boundaries

    NASA Astrophysics Data System (ADS)

    Hufenbach, W.; Grüber, B.; Gottwald, R.; Lepper, M.; Zhou, B.

    2010-12-01

    A solution method for stress concentration problems of fibre- and textile-reinforced multilayered composites with account of the influence of a circular or elliptical cut-out and of the finite outer boundary of a composite plate is presented. The method is based on complex-valued displacement functions and conformal mappings in combination with the boundary collocation and least squares methods. This allows a layer-by-layer calculation of full stress, strain, and displacement fields in a generally multilayered anisotropic plate. To verify the calculation model, extensive experimental studies have been carried out. For all the combinations of multilayered GF/PP plates, laminate lay-ups, and notch and specimen dimensions investigated so far, a very good agreement between the analytical calculations and experimental results is found to exist.

  18. Transient analysis of leaky Lamb waves with a semi-analytical finite element method.

    PubMed

    Inoue, Daisuke; Hayashi, Takahiro

    2015-09-01

    We previously formulated a semi-analytical finite element technique for Lamb waves in a plate surrounded by fluids and investigated the dispersion curves and wave structures for leaky Lamb waves. Herein, this technique is extended to the calculation of transient responses both in a plate and in fluids for dynamic loading on the plate surface. To gain fundamental insights into guided wave inspection for a water-filled pipe or tank, guided waves generated upon transient loading of a flat plate water-loaded on one side were analyzed. The results show that a quasi-Scholte mode propagating at the plate-water interface is useful for the long-range inspection of a water-loaded plate because of its non-attenuation and minimal dispersion; moreover, this mode has superior generation efficiency in the low-frequency range, while it is localized near the plate-water interface at higher frequencies.

  19. Priority survey between indicators and analytic hierarchy process analysis for green chemistry technology assessment

    PubMed Central

    Kim, Sungjune; Hong, Seokpyo; Ahn, Kilsoo; Gong, Sungyong

    2015-01-01

    Objectives This study presents the indicators and proxy variables for the quantitative assessment of green chemistry technologies and evaluates the relative importance of each assessment element by consulting experts from the fields of ecology, chemistry, safety, and public health. Methods The results collected were subjected to an analytic hierarchy process to obtain the weights of the indicators and the proxy variables. Results These weights may prove useful in avoiding having to resort to qualitative means in absence of weights between indicators when integrating the results of quantitative assessment by indicator. Conclusions This study points to the limitations of current quantitative assessment techniques for green chemistry technologies and seeks to present the future direction for quantitative assessment of green chemistry technologies. PMID:26206364

  20. Dynamical analysis of the avian-human influenza epidemic model using the semi-analytical method

    NASA Astrophysics Data System (ADS)

    Jabbari, Azizeh; Kheiri, Hossein; Bekir, Ahmet

    2015-03-01

    In this work, we present a dynamic behavior of the avian-human influenza epidemic model by using efficient computational algorithm, namely the multistage differential transform method(MsDTM). The MsDTM is used here as an algorithm for approximating the solutions of the avian-human influenza epidemic model in a sequence of time intervals. In order to show the efficiency of the method, the obtained numerical results are compared with the fourth-order Runge-Kutta method (RK4M) and differential transform method(DTM) solutions. It is shown that the MsDTM has the advantage of giving an analytical form of the solution within each time interval which is not possible in purely numerical techniques like RK4M.

  1. Gravity field error analysis for pendulum formations by a semi-analytical approach

    NASA Astrophysics Data System (ADS)

    Li, Huishu; Reubelt, Tilo; Antoni, Markus; Sneeuw, Nico

    2016-10-01

    Many geoscience disciplines push for ever higher requirements on accuracy, homogeneity and time- and space-resolution of the Earth's gravity field. Apart from better instruments or new observables, alternative satellite formations could improve the signal and error structure compared to uc(Grace). One possibility to increase the sensitivity and isotropy by adding cross-track information is a pair of satellites flying in a pendulum formation. This formation contains two satellites which have different ascending nodes and arguments of latitude, but have the same orbital height and inclination. In this study, the semi-analytical approach for efficient pre-mission error assessment is presented, and the transfer coefficients of range, range-rate and range-acceleration gravitational perturbations are derived analytically for the pendulum formation considering a set of opening angles. The new challenge is the time variations of the opening angle and the range, leading to temporally variable transfer coefficients. This is solved by Fourier expansion of the sine/cosine of the opening angle and the central angle. The transfer coefficients are further applied to assess the error patterns which are caused by different orbital parameters. The simulation results indicate that a significant improvement in accuracy and isotropy is obtained for small and medium initial opening angles of single polar pendulums, compared to uc(Grace). The optimal initial opening angles are 45° and 15° for accuracy and isotropy, respectively. For a Bender configuration, which is constituted by a polar uc(Grace) and an inclined pendulum in this paper, the behaviour of results is dependent on the inclination (prograde vs. retrograde) and on the relative baseline orientation (left or right leading). The simulation for a sun-synchronous orbit shows better results for the left leading case.

  2. Gravity field error analysis for pendulum formations by a semi-analytical approach

    NASA Astrophysics Data System (ADS)

    Li, Huishu; Reubelt, Tilo; Antoni, Markus; Sneeuw, Nico

    2017-03-01

    Many geoscience disciplines push for ever higher requirements on accuracy, homogeneity and time- and space-resolution of the Earth's gravity field. Apart from better instruments or new observables, alternative satellite formations could improve the signal and error structure compared to Grace. One possibility to increase the sensitivity and isotropy by adding cross-track information is a pair of satellites flying in a pendulum formation. This formation contains two satellites which have different ascending nodes and arguments of latitude, but have the same orbital height and inclination. In this study, the semi-analytical approach for efficient pre-mission error assessment is presented, and the transfer coefficients of range, range-rate and range-acceleration gravitational perturbations are derived analytically for the pendulum formation considering a set of opening angles. The new challenge is the time variations of the opening angle and the range, leading to temporally variable transfer coefficients. This is solved by Fourier expansion of the sine/cosine of the opening angle and the central angle. The transfer coefficients are further applied to assess the error patterns which are caused by different orbital parameters. The simulation results indicate that a significant improvement in accuracy and isotropy is obtained for small and medium initial opening angles of single polar pendulums, compared to Grace. The optimal initial opening angles are 45° and 15° for accuracy and isotropy, respectively. For a Bender configuration, which is constituted by a polar Grace and an inclined pendulum in this paper, the behaviour of results is dependent on the inclination (prograde vs. retrograde) and on the relative baseline orientation (left or right leading). The simulation for a sun-synchronous orbit shows better results for the left leading case.

  3. Crustal structure beneath two seismic stations in the Sunda-Banda arc transition zone derived from receiver function analysis

    SciTech Connect

    Syuhada; Hananto, Nugroho D.; Handayani, Lina; Puspito, Nanang T; Yudistira, Tedi; Anggono, Titi

    2015-04-24

    We analyzed receiver functions to estimate the crustal thickness and velocity structure beneath two stations of Geofon (GE) network in the Sunda-Banda arc transition zone. The stations are located in two different tectonic regimes: Sumbawa Island (station PLAI) and Timor Island (station SOEI) representing the oceanic and continental characters, respectively. We analyzed teleseismic events of 80 earthquakes to calculate the receiver functions using the time-domain iterative deconvolution technique. We employed 2D grid search (H-κ) algorithm based on the Moho interaction phases to estimate crustal thickness and Vp/Vs ratio. We also derived the S-wave velocity variation with depth beneath both stations by inverting the receiver functions. We obtained that beneath station PLAI the crustal thickness is about 27.8 km with Vp/Vs ratio 2.01. As station SOEI is covered by very thick low-velocity sediment causing unstable solution for the inversion, we modified the initial velocity model by adding the sediment thickness estimated using high frequency content of receiver functions in H-κ stacking process. We obtained the crustal thickness is about 37 km with VP/Vs ratio 2.2 beneath station SOEI. We suggest that the high Vp/Vs in station PLAI may indicate the presence of fluid ascending from the subducted plate to the volcanic arc, whereas the high Vp/Vs in station SOEI could be due to the presence of sediment and rich mafic composition in the upper crust and possibly related to the serpentinization process in the lower crust. We also suggest that the difference in velocity models and crustal thicknesses between stations PLAI and SOEI are consistent with their contrasting tectonic environments.

  4. Crustal structure beneath two seismic stations in the Sunda-Banda arc transition zone derived from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Syuhada, Hananto, Nugroho D.; Puspito, Nanang T.; Anggono, Titi; Handayani, Lina; Yudistira, Tedi

    2015-04-01

    We analyzed receiver functions to estimate the crustal thickness and velocity structure beneath two stations of Geofon (GE) network in the Sunda-Banda arc transition zone. The stations are located in two different tectonic regimes: Sumbawa Island (station PLAI) and Timor Island (station SOEI) representing the oceanic and continental characters, respectively. We analyzed teleseismic events of 80 earthquakes to calculate the receiver functions using the time-domain iterative deconvolution technique. We employed 2D grid search (H-κ) algorithm based on the Moho interaction phases to estimate crustal thickness and Vp/Vs ratio. We also derived the S-wave velocity variation with depth beneath both stations by inverting the receiver functions. We obtained that beneath station PLAI the crustal thickness is about 27.8 km with Vp/Vs ratio 2.01. As station SOEI is covered by very thick low-velocity sediment causing unstable solution for the inversion, we modified the initial velocity model by adding the sediment thickness estimated using high frequency content of receiver functions in H-κ stacking process. We obtained the crustal thickness is about 37 km with VP/Vs ratio 2.2 beneath station SOEI. We suggest that the high Vp/Vs in station PLAI may indicate the presence of fluid ascending from the subducted plate to the volcanic arc, whereas the high Vp/Vs in station SOEI could be due to the presence of sediment and rich mafic composition in the upper crust and possibly related to the serpentinization process in the lower crust. We also suggest that the difference in velocity models and crustal thicknesses between stations PLAI and SOEI are consistent with their contrasting tectonic environments.

  5. Pyrosequencing Analysis Reveals Changes in Intestinal Microbiota of Healthy Adults Who Received a Daily Dose of Immunomodulatory Probiotic Strains

    PubMed Central

    Plaza-Díaz, Julio; Fernández-Caballero, Jose Ángel; Chueca, Natalia; García, Federico; Gómez-Llorente, Carolina; Sáez-Lara, María José; Fontana, Luis; Gil, Ángel

    2015-01-01

    The colon microbiota plays a crucial role in human gastrointestinal health. Current attempts to manipulate the colon microbiota composition are aimed at finding remedies for various diseases. We have recently described the immunomodulatory effects of three probiotic strains (Lactobacillus rhamnosus CNCM I-4036, Lactobacillus paracasei CNCM I-4034, and Bifidobacterium breve CNCM I-4035). The goal of the present study was to analyze the compositions of the fecal microbiota of healthy adults who received one of these strains using high-throughput 16S ribosomal RNA gene sequencing. Bacteroides was the most abundant genus in the groups that received L. rhamnosus CNCM I-4036 or L. paracasei CNCM I-4034. The Shannon indices were significantly increased in these two groups. Our results also revealed a significant increase in the Lactobacillus genus after the intervention with L. rhamnosus CNCM I-4036. The initially different colon microbiota became homogeneous in the subjects who received L. rhamnosus CNCM I-4036. While some orders that were initially present disappeared after the administration of L. rhamnosus CNCM I-4036, other orders, such as Sphingobacteriales, Nitrospirales, Desulfobacterales, Thiotrichales, and Synergistetes, were detected after the intervention. In summary, our results show that the intake of these three bacterial strains induced changes in the colon microbiota. PMID:26016655

  6. Pyrosequencing analysis reveals changes in intestinal microbiota of healthy adults who received a daily dose of immunomodulatory probiotic strains.

    PubMed

    Plaza-Díaz, Julio; Fernández-Caballero, Jose Ángel; Chueca, Natalia; García, Federico; Gómez-Llorente, Carolina; Sáez-Lara, María José; Fontana, Luis; Gil, Ángel

    2015-05-26

    The colon microbiota plays a crucial role in human gastrointestinal health. Current attempts to manipulate the colon microbiota composition are aimed at finding remedies for various diseases. We have recently described the immunomodulatory effects of three probiotic strains (Lactobacillus rhamnosus CNCM I-4036, Lactobacillus paracasei CNCM I-4034, and Bifidobacterium breve CNCM I-4035). The goal of the present study was to analyze the compositions of the fecal microbiota of healthy adults who received one of these strains using high-throughput 16S ribosomal RNA gene sequencing. Bacteroides was the most abundant genus in the groups that received L. rhamnosus CNCM I-4036 or L. paracasei CNCM I-4034. The Shannon indices were significantly increased in these two groups. Our results also revealed a significant increase in the Lactobacillus genus after the intervention with L. rhamnosus CNCM I-4036. The initially different colon microbiota became homogeneous in the subjects who received L. rhamnosus CNCM I-4036. While some orders that were initially present disappeared after the administration of L. rhamnosus CNCM I-4036, other orders, such as Sphingobacteriales, Nitrospirales, Desulfobacterales, Thiotrichales, and Synergistetes, were detected after the intervention. In summary, our results show that the intake of these three bacterial strains induced changes in the colon microbiota.

  7. Impact of pre-analytical factors on the proteomic analysis of formalin-fixed paraffin-embedded tissue.

    PubMed

    Thompson, Seonaid M; Craven, Rachel A; Nirmalan, Niroshini J; Harnden, Patricia; Selby, Peter J; Banks, Rosamonde E

    2013-04-01

    Formalin-fixed paraffin-embedded (FFPE) tissue samples represent a tremendous potential resource for biomarker discovery, with large numbers of samples in hospital pathology departments and links to clinical information. However, the cross-linking of proteins and nucleic acids by formalin fixation has hampered analysis and proteomic studies have been restricted to using frozen tissue, which is more limited in availability as it needs to be collected specifically for research. This means that rare disease subtypes cannot be studied easily. Recently, improved extraction techniques have enabled analysis of FFPE tissue by a number of proteomic techniques. As with all clinical samples, pre-analytical factors are likely to impact on the results obtained, although overlooked in many studies. The aim of this review is to discuss the various pre-analytical factors, which include warm and cold ischaemic time, size of sample, fixation duration and temperature, tissue processing conditions, length of storage of archival tissue and storage conditions, and to review the studies that have considered these factors in more detail. In those areas where investigations are few or non-existent, illustrative examples of the possible importance of specific factors have been drawn from studies using frozen tissue or from immunohistochemical studies of FFPE tissue.

  8. Analytical and Computational Aspects of Collaborative Optimization

    NASA Technical Reports Server (NTRS)

    Alexandrov, Natalia M.; Lewis, Robert Michael

    2000-01-01

    Bilevel problem formulations have received considerable attention as an approach to multidisciplinary optimization in engineering. We examine the analytical and computational properties of one such approach, collaborative optimization. The resulting system-level optimization problems suffer from inherent computational difficulties due to the bilevel nature of the method. Most notably, it is impossible to characterize and hence identify solutions of the system-level problems because the standard first-order conditions for solutions of constrained optimization problems do not hold. The analytical features of the system-level problem make it difficult to apply conventional nonlinear programming algorithms. Simple examples illustrate the analysis and the algorithmic consequences for optimization methods. We conclude with additional observations on the practical implications of the analytical and computational properties of collaborative optimization.

  9. Studies of the analyte-carrier interface in flow injection analysis

    SciTech Connect

    Brown, S.D.

    1992-01-01

    Chemical analysis in flowing solution is popular for automation of classical methods. However, most of the classical methods are not specific enough for direct multicomponent analysis of simple mixtures. This research project has the goals of study of rapid multicomponent analysis of transient species in flowing media, and investigations of chemical reactions at interfaces and of effects of competition on distribution of products from interfacial reaction. This report summarizes work done over the past 4.5 years; support has been terminated.

  10. Optimization of MLS receivers for multipath environments

    NASA Technical Reports Server (NTRS)

    Mcalpine, G. A.; Highfill, J. H., III; Tzeng, C. P. J.; Koleyni, G.

    1978-01-01

    Reduced order receiver (suboptimal receiver) analysis in multipath environments is presented. The origin and objective of MLS is described briefly. Signal modeling in MLS the optimum receiver is also included and a description of a computer oriented technique which was used in the simulation study of the suboptimal receiver is provided. Results and conclusion obtained from the research for the suboptimal receiver are reported.

  11. Analytical techniques: A compilation

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A compilation, containing articles on a number of analytical techniques for quality control engineers and laboratory workers, is presented. Data cover techniques for testing electronic, mechanical, and optical systems, nondestructive testing techniques, and gas analysis techniques.

  12. Content Analysis of Meta-Analytic Studies from I/O Psychology.

    ERIC Educational Resources Information Center

    Cornwell, John M.

    The use of meta-analysis in industrial and organizational psychology has become quite common. Unfortunately, the understanding and research necessary to ensure appropriate application of the technique have not been as widespread. As part of a larger study, a content analysis of meta-analyses from the industrial and organizational psychological…

  13. Analysis and Reflections on the Third Learning Analytics and Knowledge Conference (LAK 2013)

    ERIC Educational Resources Information Center

    Ochoa, Xavier; Suthers, Dan; Verbert, Katrien; Duval, Erik

    2014-01-01

    Analyzing a conference, especially one as young and focused as LAK, provides the opportunity to observe the structure and contributions of the scientific community around it. This work will perform a Scientometric analysis, coupled with a more in-depth manual content analysis, to extract this insight from the proceedings and program of LAK 2013.…

  14. Recursive organizer (ROR): an analytic framework for sequence-based association analysis.

    PubMed

    Zhao, Lue Ping; Huang, Xin

    2013-07-01

    The advent of next-generation sequencing technologies affords the ability to sequence thousands of subjects cost-effectively, and is revolutionizing the landscape of genetic research. With the evolving genotyping/sequencing technologies, it is not unrealistic to expect that we will soon obtain a pair of diploidic fully phased genome sequences from each subject in the near future. Here, in light of this potential, we propose an analytic framework called, recursive organizer (ROR), which recursively groups sequence variants based upon sequence similarities and their empirical disease associations, into fewer and potentially more interpretable super sequence variants (SSV). As an illustration, we applied ROR to assess an association between HLA-DRB1 and type 1 diabetes (T1D), discovering SSVs of HLA-DRB1 with sequence data from the Wellcome Trust Case Control Consortium. Specifically, ROR reduces 36 observed unique HLA-DRB1 sequences into 8 SSVs that empirically associate with T1D, a fourfold reduction of sequence complexity. Using HLA-DRB1 data from Type 1 Diabetes Genetics Consortium as cases and data from Fred Hutchinson Cancer Research Center as controls, we are able to validate associations of these SSVs with T1D. Further, SSVs consist of nine nucleotides, and each associates with its corresponding amino acids. Detailed examination of these selected amino acids reveals their potential functional roles in protein structures and possible implication to the mechanism of T1D.

  15. Analytical analysis of modulated signal in apertureless scanning near-field optical microscopy.

    PubMed

    Lo, Y L; Chuang, C H

    2007-11-26

    Eliminating background-scattering effects from the detected signal is crucial in improving the performance of super-high-resolution apertureless scanning near-field optical microscopy (A-SNOM). Using a simple mathematical model of the A-SNOM detected signal, this study explores the respective effects of the phase modulation depth, the wavelength and angle of the incident light, and the amplitude of the tip vibration on the signal contrast and signal intensity. In general, the results show that the background-noise decays as the order of the Bessel function increases and that higher-order harmonic frequencies yield an improved signal contrast. Additionally, it is found that incident light with a longer wavelength improves the signal contrast for a constant order of modulation frequency. The signal contrast can also be improved by reducing the incident angle of the incident light. Finally, it is demonstrated that sample stage scanning yields an improved imaging result. However, tip scanning provides a reasonable low-cost and faster solution in the smaller scan area. The analytical results presented in this study enable a better understanding of the complex detected signal in A-SNOM and provide insights into methods of improving the signal contrast of the A-SNOM measurement.

  16. Analysis of plasticizers in PVC medical devices: Performance comparison of eight analytical methods.

    PubMed

    Bernard, L; Bourdeaux, D; Pereira, B; Azaroual, N; Barthélémy, C; Breysse, C; Chennell, P; Cueff, R; Dine, T; Eljezi, T; Feutry, F; Genay, S; Kambia, N; Lecoeur, M; Masse, M; Odou, P; Radaniel, T; Simon, N; Vaccher, C; Verlhac, C; Yessad, M; Décaudin, B; Sautou, V

    2017-01-01

    A wide variety of medical devices (MDs) used in hospitals are made of flexible plasticized polyvinylchloride (PVC). Different plasticizers are present in variable amounts in the PVC matrix of the devices and can leach out into the infused solutions and may enter into contact with the patients. The ARMED(1) project aims to assess the migration of these plasticizers from medical devices and therefore the level of exposure in patients. For the first task of the project, eight methods were developed to directly detect and quantify the plasticizers in the PVC matrix of the MDs. We compared the overall performances of the analytical methods using standardized and validated criteria in order to provide the scientific community with the guidance and the technical specifications of each method for the intended application. We have shown that routine rapid screening could be performed directly on the MDs using the FTIR technique, with cost-effective analyses. LC techniques may also be used, but with limits and only with individual quantification of the main plasticizers expected in the PVC matrix. GC techniques, especially GC-MS, are both more specific and more sensitive than other techniques. NMR is a robust and specific technique to precisely discriminate all plasticizers in a MD but is limited by its cost and its low ability to detect and quantify plasticizer contamination, e.g. by DEHP. All these results have been confirmed by a real test, called the " blind test " carried out on 10 MD samples.

  17. Re-Paying Attention to Visitor Behavior: A Re-Analysis using Meta-Analytic Techniques.

    PubMed

    Castro, Yone; Botella, Juan; Asensio, Mikel

    2016-06-20

    The present study describes a meta-analytic review of museum visitors' behavior. Although there is a large number of visitor studies available, their cumulative importance has not been determined due to the lack of rigorous methods to determine common causes of visitors' behaviors. We analyzed Serrell's (1998) database of 110 studies, defining a number of variables that measure visitors' behaviors in exhibition spaces which exceeded the most typical and obvious ones. We defined four indexes of effect size and obtained their combined estimates: average time per feature [ATF● = 0.43 (0.49; 0.37)], percentage of diligent visitors [dv● = 30% (0.39; 0.23)], inverse of velocity [Iv● = 4.07 min/100m2 (4.55; 3.59)], and stops per feature [SF● = 0.35 (0.38; 0.33)], and we analyzed the role of relevant moderating variables. Key findings indicate, for example, that the visiting time for each display element relates to the size of the exhibition and its newness, and visitor walking speed is higher in large exhibit areas. The indexes obtained in this study can be understood as references to be used for comparison with new evaluations. They may help to predict people's behavior and appreciation of new exhibitions, identifying important problems in museum designs, and providing new research tools for this field.

  18. Ambient aerodynamic ionization source for remote analyte sampling and mass spectrometric analysis.

    PubMed

    Dixon, R Brent; Sampson, Jason S; Hawkridge, Adam M; Muddiman, David C

    2008-07-01

    The use of aerodynamic devices in ambient ionization source development has become increasingly prevalent in the field of mass spectrometry. In this study, an air ejector has been constructed from inexpensive, commercially available components to incorporate an electrospray ionization emitter within the exhaust jet of the device. This novel aerodynamic device, herein termed remote analyte sampling, transport, and ionization relay (RASTIR) was used to remotely sample neutral species in the ambient and entrain them into an electrospray plume where they were subsequently ionized and detected using a linear ion trap Fourier transform mass spectrometer. Two sets of experiments were performed in the ambient environment to demonstrate the device's utility. The first involved the remote (approximately 1 ft) vacuum collection of pure sample particulates (i.e., dry powder) from a glass slide, entrainment and ionization at the ESI emitter, and mass spectrometric detection. The second experiment involved the capture (vacuum collection) of matrix-assisted laser desorbed proteins followed by entrainment in the ESI emitter plume, multiple charging, and mass spectrometric detection. This approach is in principle a RASTIR-assisted matrix-assisted laser desorption electrospray ionization source (Sampson, J. S.; Hawkridge, A. M.; Muddiman, D. C. J. Am. Soc. Mass Spectrom. 2006, 17, 1712-1716; Rapid Commun. Mass Spectrom. 2007, 21, 1150-1154.). A detailed description of the device construction, operational parameters, and preliminary small molecule and protein data are presented.

  19. General analytical approach for sound transmission loss analysis through a thick metamaterial plate

    SciTech Connect

    Oudich, Mourad; Zhou, Xiaoming; Badreddine Assouar, M.

    2014-11-21

    We report theoretically and numerically on the sound transmission loss performance through a thick plate-type acoustic metamaterial made of spring-mass resonators attached to the surface of a homogeneous elastic plate. Two general analytical approaches based on plane wave expansion were developed to calculate both the sound transmission loss through the metamaterial plate (thick and thin) and its band structure. The first one can be applied to thick plate systems to study the sound transmission for any normal or oblique incident sound pressure. The second approach gives the metamaterial dispersion behavior to describe the vibrational motions of the plate, which helps to understand the physics behind sound radiation through air by the structure. Computed results show that high sound transmission loss up to 72 dB at 2 kHz is reached with a thick metamaterial plate while only 23 dB can be obtained for a simple homogeneous plate with the same thickness. Such plate-type acoustic metamaterial can be a very effective solution for high performance sound insulation and structural vibration shielding in the very low-frequency range.

  20. Material degradation due to moisture and temperature. Part 1: mathematical model, analysis, and analytical solutions

    NASA Astrophysics Data System (ADS)

    Xu, C.; Mudunuru, M. K.; Nakshatrala, K. B.

    2016-11-01

    The mechanical response, serviceability, and load-bearing capacity of materials and structural components can be adversely affected due to external stimuli, which include exposure to a corrosive chemical species, high temperatures, temperature fluctuations (i.e., freezing-thawing), cyclic mechanical loading, just to name a few. It is, therefore, of paramount importance in several branches of engineering—ranging from aerospace engineering, civil engineering to biomedical engineering—to have a fundamental understanding of degradation of materials, as the materials in these applications are often subjected to adverse environments. As a result of recent advancements in material science, new materials such as fiber-reinforced polymers and multi-functional materials that exhibit high ductility have been developed and widely used, for example, as infrastructural materials or in medical devices (e.g., stents). The traditional small-strain approaches of modeling these materials will not be adequate. In this paper, we study degradation of materials due to an exposure to chemical species and temperature under large strain and large deformations. In the first part of our research work, we present a consistent mathematical model with firm thermodynamic underpinning. We then obtain semi-analytical solutions of several canonical problems to illustrate the nature of the quasi-static and unsteady behaviors of degrading hyperelastic solids.

  1. 2.5D S-wave velocity model of the TESZ area in northern Poland from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Wilde-Piorko, Monika; Polkowski, Marcin; Grad, Marek

    2016-04-01

    Receiver function (RF) locally provides the signature of sharp seismic discontinuities and information about the shear wave (S-wave) velocity distribution beneath the seismic station. The data recorded by "13 BB Star" broadband seismic stations (Grad et al., 2015) and by few PASSEQ broadband seismic stations (Wilde-Piórko et al., 2008) are analysed to investigate the crustal and upper mantle structure in the Trans-European Suture Zone (TESZ) in northern Poland. The TESZ is one of the most prominent suture zones in Europe separating the young Palaeozoic platform from the much older Precambrian East European craton. Compilation of over thirty deep seismic refraction and wide angle reflection profiles, vertical seismic profiling in over one hundred thousand boreholes and magnetic, gravity, magnetotelluric and thermal methods allowed for creation a high-resolution 3D P-wave velocity model down to 60 km depth in the area of Poland (Grad et al. 2016). On the other hand the receiver function methods give an opportunity for creation the S-wave velocity model. Modified ray-tracing method (Langston, 1977) are used to calculate the response of the structure with dipping interfaces to the incoming plane wave with fixed slowness and back-azimuth. 3D P-wave velocity model are interpolated to 2.5D P-wave velocity model beneath each seismic station and synthetic back-azimuthal sections of receiver function are calculated for different Vp/Vs ratio. Densities are calculated with combined formulas of Berteussen (1977) and Gardner et al. (1974). Next, the synthetic back-azimuthal sections of RF are compared with observed back-azimuthal sections of RF for "13 BB Star" and PASSEQ seismic stations to find the best 2.5D S-wave models down to 60 km depth. National Science Centre Poland provided financial support for this work by NCN grant DEC-2011/02/A/ST10/00284.

  2. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis.

    PubMed

    Casas, Francisco J; Ortiz, David; Villa, Enrique; Cano, Juan L; Cagigas, Jaime; Pérez, Ana R; Aja, Beatriz; Terán, J Vicente; de la Fuente, Luisa; Artal, Eduardo; Hoyland, Roger; Génova-Santos, Ricardo

    2015-08-05

    This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process.

  3. A direction-sensitive model of atmospheric noise and its application to the analysis of HF receiving antennas

    NASA Astrophysics Data System (ADS)

    Coleman, C. J.

    2002-05-01

    Global maps of lightning occurrence are combined with ray tracing propagation calculations to form a direction-sensitive model of atmospheric noise. The model suggests a very complex directional behavior that can vary strongly with location, time, season, sunspot number, and frequency. It is shown that the directional variability of noise, when coupled with the directional variability of antenna gain, can lead to marked changes in noise outcome between different antennas. The implication of directional varying noise for the optimum choice of receiver antenna is explored.

  4. Receiver design, performance analysis, and evaluation for space-borne laser altimeters and space-to-space laser ranging systems

    NASA Technical Reports Server (NTRS)

    Davidson, Frederic M.; Sun, Xiaoli; Field, Christopher T.

    1995-01-01

    This Interim report consists of a manuscript, 'Receiver Design for Satellite to Satellite Laser Ranging Instrument,' and copies of two papers we co-authored, 'Demonstration of High Sensitivity Laser Ranging System' and 'Semiconductor Laser-Based Ranging Instrument for Earth Gravity Measurements. ' These two papers were presented at the conference Semiconductor Lasers, Advanced Devices and Applications, August 21 -23, 1995, Keystone Colorado. The manuscript is a draft in the preparation for publication, which summarizes the theory we developed on space-borne laser ranging instrument for gravity measurements.

  5. Lithosphere/Asthenosphere Structure beneath the Mendocino Triple Junction from the Analysis of Surface Wave, Ambient Noise, and Receiver Functions

    NASA Astrophysics Data System (ADS)

    Liu, K.; Zhai, Y.; Levander, A.; Porritt, R. W.; Allen, R. M.; Schmandt, B.; Humphreys, E.; O'Driscoll, L.

    2010-12-01

    We have developed a 3-D shear velocity model using finite-frequency Rayleigh wave phase velocity dispersion, PdS receiver functions, and ambient noise tomography to better understand the complex lithosphere/asthenosphere structures in the Mendocino Triple Junction (MTJ) region. Using approximately 100 events (July 2007-December 2008) recorded by the stations of the Flexible Array Mendocino Experiment (FAME), the USArray Transportable Array (TA) network, and the Berkeley Digital Seismograph network, we have obtained the phase velocities (20-100s) from the finite-frequency Rayleigh wave tomography, which agrees well with the ambient noise tomography results (7-40 s, Porritt & Allen, 2010) in the overlapping period range. We subsequently inverted for a 3-D Vs model on a 0.25°x0.25° grid from the combined dispersion datasets, constrained by interface depths from the PdS receiver functions (Zhai & Levander, 2010). The resulting crustal and upper mantle Vs model (~150 km) reveals strong lateral heterogeneity in the subduction and transform regimes of the Mendocino Triple Junction region where the Gorda, Pacific, and North American plates intersect. The subducting Gorda slab is well-imaged as an eastward-dipping high-velocity anomaly to ~100 km depth. At the same depth to the east we observe a large-scale low velocity zone, which is the mantle wedge beneath the North American Plate. The southern edge of the Gorda plate (SEDGE) is imaged at 80-100 km depth and is in excellent agreement with measurements made from PdS receiver functions, body-wave tomography (Schmandt & Humphreys, 2010; Obrebski et al., 2010), and active source studies. At depths greater than 80 km, we interpret low velocities under the Cascadia subduction zone as the asthenosphere below the Gorda plate, in agreement with measured LAB depths from RFs. South of the SEDGE shallow strong low-velocities appear beneath the transform region, which we interpret as the asthenosphere in the slab-gap region left by

  6. Development of an analytical method for the simultaneous analysis of MCPD esters and glycidyl esters in oil-based foodstuffs.

    PubMed

    Ermacora, Alessia; Hrnčiřík, Karel

    2014-01-01

    Substantial progress has been recently made in the development and optimisation of analytical methods for the quantification of 2-MCPD, 3-MCPD and glycidyl esters in oils and fats, and there are a few methods currently available that allow a reliable quantification of these contaminants in bulk oils and fats. On the other hand, no standard method for the analysis of foodstuffs has yet been established. The aim of this study was the development and validation of a new method for the simultaneous quantification of 2-MCPD, 3-MCPD and glycidyl esters in oil-based food products. The developed protocol includes a first step of liquid-liquid extraction and purification of the lipophilic substances of the sample, followed by the application of a previously developed procedure based on acid transesterification, for the indirect quantification of these contaminants in oils and fats. The method validation was carried out on food products (fat-based spreads, creams, margarine, mayonnaise) manufactured in-house, in order to control the manufacturing process and account for any food matrix-analyte interactions (the sample spiking was carried out on the single components used for the formulations rather than the final products). The method showed good accuracy (the recoveries ranged from 97% to 106% for bound 3-MCPD and 2-MCPD and from 88% to 115% for bound glycidol) and sensitivity (the LOD was 0.04 and 0.05 mg kg(-1) for bound MCPD and glycidol, respectively). Repeatability and reproducibility were satisfactory (RSD below 2% and 5%, respectively) for all analytes. The levels of salts and surface-active compounds in the formulation were found to have no impact on the accuracy and the other parameters of the method.

  7. Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry.

    PubMed

    Smart, Kathleen F; Aggio, Raphael B M; Van Houtte, Jeremy R; Villas-Bôas, Silas G

    2010-09-01

    This protocol describes an analytical platform for the analysis of intra- and extracellular metabolites of microbial cells (yeast, filamentous fungi and bacteria) using gas chromatography-mass spectrometry (GC-MS). The protocol is subdivided into sampling, sample preparation, chemical derivatization of metabolites, GC-MS analysis and data processing and analysis. This protocol uses two robust quenching methods for microbial cultures, the first of which, cold glycerol-saline quenching, causes reduced leakage of intracellular metabolites, thus allowing a more reliable separation of intra- and extracellular metabolites with simultaneous stopping of cell metabolism. The second, fast filtration, is specifically designed for quenching filamentous micro-organisms. These sampling techniques are combined with an easy sample-preparation procedure and a fast chemical derivatization reaction using methyl chloroformate. This reaction takes place at room temperature, in aqueous medium, and is less prone to matrix effect compared with other derivatizations. This protocol takes an average of 10 d to complete and enables the simultaneous analysis of hundreds of metabolites from the central carbon metabolism (amino and nonamino organic acids, phosphorylated organic acids and fatty acid intermediates) using an in-house MS library and a data analysis pipeline consisting of two free software programs (Automated Mass Deconvolution and Identification System (AMDIS) and R).

  8. Spatial Analysis in Determination Of Flood Prone Areas Using Geographic Information System and Analytical Hierarchy Process at Sungai Sembrong's Catchment

    NASA Astrophysics Data System (ADS)

    Bukari, S. M.; Ahmad, M. A.; Wai, T. L.; Kaamin, M.; Alimin, N.

    2016-07-01

    Floods that struck Johor state in 2006 and 2007 and the East Coastal in 2014 have triggered a greatly impact to the flood management here in Malaysia. Accordingly, this study conducted to determine potential areas of flooding, especially in Batu Pahat district since it faces terrifying experienced with heavy flood. This objective is archived by using the application of Geographic Information Systems (GIS) on study area of flood risk location at the watershed area of Sungai Sembrong. GIS functions as spatial analysis is capable to produce new information based on analysis of data stored in the system. Meanwhile the Analytical Hierarchy Process (AHP) was used as a method for setting up in decision making concerning the existing data. By using AHP method, preparation and position of the criteria and parameters required in GIS are neater and easier to analyze. Through this study, a flood prone area in the watershed of Sungai Sembrong was identified with the help of GIS and AHP. Analysis was conducted to test two different cell sizes, which are 30 and 5. The analysis of flood prone areas were tested on both cell sizes with two different water levels and the results of the analysis were displayed by GIS. Therefore, the use of AHP and GIS are effective and able to determine the potential flood plain areas in the watershed area of Sungai Sembrong.

  9. An Integrated Geovisual Analytics Framework for Analysis of Energy Consumption Data and Renewable Energy Potentials

    SciTech Connect

    Omitaomu, Olufemi A; Kramer, Ian S; Kodysh, Jeffrey B; Bhaduri, Budhendra L; Steed, Chad A; Karthik, Rajasekar; Nugent, Philip J; Myers, Aaron T

    2012-01-01

    We present an integrated geovisual analytics framework for utility consumers to interactively analyze and benchmark their energy consumption. The framework uses energy and property data already available with the utility companies and county governments respectively. The motivation for the developed framework is the need for citizens to go beyond the conventional utility bills in understanding the patterns in their energy consumption. There is also a need for citizens to go beyond one-time improvements that are often not monitored and measured over time. Some of the features of the framework include the ability for citizens to visualize their historical energy consumption data along with weather data in their location. The quantity of historical energy data available is significantly more than what is available from utility bills. An overlay of the weather data provides users with a visual correlation between weather patterns and their energy consumption patterns. Another feature of the framework is the ability for citizens to compare their consumption on an aggregated basis to that of their peers other citizens living in houses of similar size and age and within the same or different geographical boundaries, such as subdivision, zip code, or county. The users could also compare their consumption to others based on the size of their family and other attributes. This feature could help citizens determine if they are among the best in class . The framework can also be used by the utility companies to better understand their customers and to plan their services. To make the framework easily accessible, it is developed to be compatible with mobile consumer electronics devices.

  10. The magnetic particle in a box: Analytic and micromagnetic analysis of probe-localized spin wave modes

    NASA Astrophysics Data System (ADS)

    Adur, Rohan; Du, Chunhui; Manuilov, Sergei A.; Wang, Hailong; Yang, Fengyuan; Pelekhov, Denis V.; Hammel, P. Chris

    2015-05-01

    The dipole field from a probe magnet can be used to localize a discrete spectrum of standing spin wave modes in a continuous ferromagnetic thin film without lithographic modification to the film. Obtaining the resonance field for a localized mode is not trivial due to the effect of the confined and inhomogeneous magnetization precession. We compare the results of micromagnetic and analytic methods to find the resonance field of localized modes in a ferromagnetic thin film, and investigate the accuracy of these methods by comparing with a numerical minimization technique that assumes Bessel function modes with pinned boundary conditions. We find that the micromagnetic technique, while computationally more intensive, reveals that the true magnetization profiles of localized modes are similar to Bessel functions with gradually decaying dynamic magnetization at the mode edges. We also find that an analytic solution, which is simple to implement and computationally much faster than other methods, accurately describes the resonance field of localized modes when exchange fields are negligible, and demonstrating the accessibility of localized mode analysis.

  11. A analytical method to low-low satellite-to-satellite tracking (ll-SST) error analysis

    NASA Astrophysics Data System (ADS)

    Cai, Lin; Zhou, Zebing; Bai, Yanzheng

    2014-05-01

    The conventional methods of error analysis for low-low satellite-to-satellite tracking (ll-SST) missions are mainly based on least-squares (LS) method, which addresses the whole effect of measurement errors and estimate the resolution of gravity field models mainly from a numerical point of view. A direct analytical expression between power spectral density of the ll-SST measurements and spherical harmonic coefficients of the Earth's gravity model is derived based on the relationship between temporal frequencies and sphere harmonics. In this study much effort has been put into the establishment of the observation equation, which derived from the linear perturbations theory and control theory, and the computation of the average power acceleration in the north direction with respect to a local north-oriented frame, which relates to the orthonormalization of derivatives of the Legendre functions. This method provides a physical insight into the relation between mission parameters, instrument parameters and gravity field parameters. In contrast, the least-squares method is mainly based on a mathematical viewpoint. The result explicitly expresses the relationship, which enables us to estimate the parameters of ll-SST missions quantitatively and directly, especially for analyzing the frequency characteristics of measurement noise. By taking advantage of the analytical expression, we discuss the effects of range, range-rate and non-conservative forces measurements errors on the gravity field recovery.

  12. The magnetic particle in a box: Analytic and micromagnetic analysis of probe-localized spin wave modes

    SciTech Connect

    Adur, Rohan Du, Chunhui; Manuilov, Sergei A.; Wang, Hailong; Yang, Fengyuan; Pelekhov, Denis V.; Hammel, P. Chris

    2015-05-07

    The dipole field from a probe magnet can be used to localize a discrete spectrum of standing spin wave modes in a continuous ferromagnetic thin film without lithographic modification to the film. Obtaining the resonance field for a localized mode is not trivial due to the effect of the confined and inhomogeneous magnetization precession. We compare the results of micromagnetic and analytic methods to find the resonance field of localized modes in a ferromagnetic thin film, and investigate the accuracy of these methods by comparing with a numerical minimization technique that assumes Bessel function modes with pinned boundary conditions. We find that the micromagnetic technique, while computationally more intensive, reveals that the true magnetization profiles of localized modes are similar to Bessel functions with gradually decaying dynamic magnetization at the mode edges. We also find that an analytic solution, which is simple to implement and computationally much faster than other methods, accurately describes the resonance field of localized modes when exchange fields are negligible, and demonstrating the accessibility of localized mode analysis.

  13. Is food allergen analysis flawed? Health and supply chain risks and a proposed framework to address urgent analytical needs.

    PubMed

    Walker, M J; Burns, D T; Elliott, C T; Gowland, M H; Mills, E N Clare

    2016-01-07

    Food allergy is an increasing problem for those affected, their families or carers, the food industry and for regulators. The food supply chain is highly vulnerable to fraud involving food allergens, risking fatalities and severe reputational damage to the food industry. Many facets are being pursued to ameliorate the difficulties including better food labelling and the concept of thresholds of elicitation of allergy symptoms as risk management tools. These efforts depend to a high degree on the ability reliably to detect and quantify food allergens; yet all current analytical approaches exhibit severe deficiencies that jeopardise accurate results being produced particularly in terms of the risks of false positive and false negative reporting. If we fail to realise the promise of current risk assessment and risk management of food allergens through lack of the ability to measure food allergens reproducibly and with traceability to an international unit of measurement, the analytical community will have failed a significant societal challenge. Three distinct but interrelated areas of analytical work are urgently needed to address the substantial gaps identified: (a) a coordinated international programme for the production of properly characterised clinically relevant reference materials and calibrants for food allergen analysis; (b) an international programme to widen the scope of proteomics and genomics bioinformatics for the genera containing the major allergens to address problems in ELISA, MS and DNA methods; (c) the initiation of a coordinated international programme leading to reference methods for allergen proteins that provide results traceable to the SI. This article describes in more detail food allergy, the risks of inapplicable or flawed allergen analyses with examples and a proposed framework, including clinically relevant incurred allergen concentrations, to address the currently unmet and urgently required analytical requirements. Support for the

  14. Analysis of environmental contamination resulting from catastrophic incidents: part 2. Building laboratory capability by selecting and developing analytical methodologies.

    PubMed

    Magnuson, Matthew; Campisano, Romy; Griggs, John; Fitz-James, Schatzi; Hall, Kathy; Mapp, Latisha; Mullins, Marissa; Nichols, Tonya; Shah, Sanjiv; Silvestri, Erin; Smith, Terry; Willison, Stuart; Ernst, Hiba

    2014-11-01

    Catastrophic incidents can generate a large number of samples of analytically diverse types, including forensic, clinical, environmental, food, and others. Environmental samples include water, wastewater, soil, air, urban building and infrastructure materials, and surface residue. Such samples may arise not only from contamination from the incident but also from the multitude of activities surrounding the response to the incident, including decontamination. This document summarizes a range of activities to help build laboratory capability in preparation for sample analysis following a catastrophic incident, including selection and development of fit-for-purpose analytical methods for chemical, biological, and radiological contaminants. Fit-for-purpose methods are those which have been selected to meet project specific data quality objectives. For example, methods could be fit for screening contamination in the early phases of investigation of contamination incidents because they are rapid and easily implemented, but those same methods may not be fit for the purpose of remediating the environment to acceptable levels when a more sensitive method is required. While the exact data quality objectives defining fitness-for-purpose can vary with each incident, a governing principle of the method selection and development process for environmental remediation and recovery is based on achieving high throughput while maintaining high quality analytical results. This paper illustrates the result of applying this principle, in the form of a compendium of analytical methods for contaminants of interest. The compendium is based on experience with actual incidents, where appropriate and available. This paper also discusses efforts aimed at adaptation of existing methods to increase fitness-for-purpose and development of innovative methods when necessary. The contaminants of interest are primarily those potentially released through catastrophes resulting from malicious activity

  15. Non-linear waveform analysis for water-layer response and its application to high-frequency receiver function analysis using OBS array

    NASA Astrophysics Data System (ADS)

    Akuhara, Takeshi; Mochizuki, Kimihiro; Kawakatsu, Hitoshi; Takeuchi, Nozomu

    2016-09-01

    Determination of a response of the sea water column to teleseismic plane wave is important to suppress adverse effects of water reverberations in calculating receiver functions (RFs) using ocean-bottom seismometer (OBS) records. We present a novel non-linear waveform analysis method using the simulated annealing algorithm to determine such a water-layer response recorded by an OBS array. We then demonstrate its usefulness for the RF estimation through its application to synthetic and observed data. Synthetic experiments suggest that the water-layer response constrained in this way has a potential to improve RFs of OBS records drastically even in the high-frequency range (to 4 Hz). By applying it to data observed by the OBS array around the Kii Peninsula, southwestern Japan, we identified a low-velocity zone at the top of the subducting Philippine Sea plate. This zone may represent the incoming fluid-rich sediment layer that has been reported by active-source seismic survey.

  16. Concept mapping and network analysis: an analytic approach to measure ties among constructs.

    PubMed

    Goldman, Alyssa W; Kane, Mary

    2014-12-01

    Group concept mapping is a mixed-methods approach that helps a group visually represent its ideas on a topic of interest through a series of related maps. The maps and additional graphics are useful for planning, evaluation and theory development. Group concept maps are typically described, interpreted and utilized through points, clusters and distances, and the implications of these features in understanding how constructs relate to one another. This paper focuses on the application of network analysis to group concept mapping to quantify the strength and directionality of relationships among clusters. The authors outline the steps of this analysis, and illustrate its practical use through an organizational strategic planning example. Additional benefits of this analysis to evaluation projects are also discussed, supporting the overall utility of this supplemental technique to the standard concept mapping methodology.

  17. [Analysis of reticulocytes: manual microscopy, flow analyzers or image analyzers? (analytical review)].

    PubMed

    Piatnitskiĭ, A M; Medovyĭ, V S; Parpara, A A

    2007-10-01

    Three procedures for determining the quantity and composition of reticulocytes (visual analysis during manual microscopy; flow cytometry, semi-automatic analysis using a computerized microscopy unit) are compared. The errors characteristics for each procedure and the reasons why manual analysis still remains most used are discussed. The paper points out that it is impossible to draw a conclusion on the accuracy of the procedures, by using the values of the correlation coefficient. Evidence is provided for the thesis that the statistical accuracy may be achieved only when the image analyzer of a computerized microscopy unit is employed, therefore this procedure is recommended for use as a reference one. The characteristics of a procedure for analyzing reticulocytes by means of a MEKOS-Ts2 computerized microscopy unit are presented.

  18. An analytical and experimental stress analysis of a practical mode II fracture-test specimen

    NASA Technical Reports Server (NTRS)

    Chisholm, D. B.; Jones, D. L.

    1975-01-01

    A boundary collocation method has been employed to determine the Mode II stress intensity factors for a pair of through-the-thickness edge cracks in a finite isotropic plate. An elastostatic analysis has been carried out in terms of the complete Williams stress function employing both even and odd components. The results of the numerical analysis were verified by a two-step procedure whereby the symmetric and antisymmetric portions of the solution were independently compared with existing solutions. The complete solution was verified by comparison with a photoelastic analysis. A compact shear specimen (CSS) of Hysol epoxy resin was loaded in a photoelastic experiment designed to study the isochromatic fringe patterns resulting from the Mode II crack tip stress distribution. The experiment verified that a pure Mode II stress distribution existed in the neighborhood of the crack tips and confirmed the accuracy of the boundary collocation solution for the Mode II stress intensity factors.

  19. Mission Analysis Program for Solar Electric Propulsion (MAPSEP). Volume 1: Analytical manual

    NASA Technical Reports Server (NTRS)

    Hong, P. E.; Shults, G. L.; Boain, R. J.; Huling, K. R.; Wilson, T.

    1974-01-01

    The mission analysis program for solar electric propulsion (MAPSEP) is comprised of the basic modes: TOPSEP (trajectory generation), GODSEP (linear error analysis), and SIMSEP (simulation). The program is designed to analyze any low thrust mission with respect to trajectory performance, guidance and navigation, and to provide system related requirements for the purpose of vehicle design. The MAPSEP organization is described along with all models and algorithms. Topics discussed include: trajectory and error covariance propagation methods, orbit determination processes, thrust modeling, and trajectory correction (guidance) schemes.

  20. PASCO: Structural panel analysis and sizing code, capability and analytical foundations

    NASA Technical Reports Server (NTRS)

    Stroud, W. J.; Anderson, M. S.

    1980-01-01

    A computer code denoted PASCO which can be used for analyzing and sizing uniaxially-stiffened composite panels is described. Buckling and vibration analyses are carried out with a linked-plate analysis computer code denoted VIPASA, which is incorporated in PASCO. Sizing is based on nonlinear mathematical programming techniques and employs a computer code denoted CONMIN, also incorporated in PASCO. Design requirements considered are initial buckling, material strength, stiffness, and vibration frequency. The capability of the PASCO computer code and the approach used in the structural analysis and sizing are described.

  1. Analytical solutions in R + qRn cosmology from singularity analysis

    NASA Astrophysics Data System (ADS)

    Paliathanasis, Andronikos; Leach, P. G. L.

    2016-08-01

    The integrability of higher-order theories of gravity is of importance in the determining the properties of these models and so their viability as models of reality. An important tool in the establishment of integrability is the singularity analysis. We apply this analysis to the case of fourth-order theory of gravity f (R) = R + qRn to establish those values of the free parameters q and n for which integrability in this sense exists. As a preliminary we examine the well-known case of n = 4 / 3.

  2. Suicide Attempt Characteristics Among Veterans and Active-Duty Service Members Receiving Mental Health Services: A Pooled Data Analysis

    PubMed Central

    Villatte, Jennifer L.; O’Connor, Stephen S.; Leitner, Rebecca; Kerbrat, Amanda H.; Johnson, Lora L.; Gutierrez, Peter M.

    2015-01-01

    Past suicidal behaviors are among the strongest and most consistent predictors of eventual suicide and may be particularly salient in military suicide. The current study compared characteristics of suicide attempts in veterans (N = 746) and active-duty service members (N = 1,013) receiving treatment for acute suicide risk. Baseline data from six randomized controlled trials were pooled and analyzed using robust regression. Service members had greater odds of having attempted suicide relative to veterans, though there were no differences in number of attempts made. Service members also had higher rates of premilitary suicide attempts and nonsuicidal self-injury (NSSI). Veterans disproportionately attempted suicide by means of overdose. In veterans, combat deployment was associated with lower odds of lifetime suicide attempt, while history of NSSI was associated with greater attempt odds. Neither was significantly associated with lifetime suicide attempt in service members. Implications for suicide assessment and treatment are discussed. PMID:26740909

  3. The Thirty Gigahertz Instrument Receiver for the QUIJOTE Experiment: Preliminary Polarization Measurements and Systematic-Error Analysis

    PubMed Central

    Casas, Francisco J.; Ortiz, David; Villa, Enrique; Cano, Juan L.; Cagigas, Jaime; Pérez, Ana R.; Aja, Beatriz; Terán, J. Vicente; de la Fuente, Luisa; Artal, Eduardo; Hoyland, Roger; Génova-Santos, Ricardo

    2015-01-01

    This paper presents preliminary polarization measurements and systematic-error characterization of the Thirty Gigahertz Instrument receiver developed for the QUIJOTE experiment. The instrument has been designed to measure the polarization of Cosmic Microwave Background radiation from the sky, obtaining the Q, U, and I Stokes parameters of the incoming signal simultaneously. Two kinds of linearly polarized input signals have been used as excitations in the polarimeter measurement tests in the laboratory; these show consistent results in terms of the Stokes parameters obtained. A measurement-based systematic-error characterization technique has been used in order to determine the possible sources of instrumental errors and to assist in the polarimeter calibration process. PMID:26251906

  4. Erosion of the continental lithosphere at the cusps of the Calabrian arc: Evidence from S receiver functions analysis

    NASA Astrophysics Data System (ADS)

    Miller, Meghan S.; Piana Agostinetti, Nicola

    2011-12-01

    Mediterranean tectonics has been characterized by an irregular, complex temporal evolution with episodic rollback and retreat of the subducted plate followed by period of slow trench-migration. To provide insight into the geodynamics of the Calabrian arc, we image the characteristics and lithospheric structure of the convergent, Apulian and Hyblean forelands at the cusps of the arc. Specifically we investigate the crustal and lithospheric thicknesses using teleseismic S-to-p converted phases, applied to the Adria-Africa plate margin for the first time. We find that the Moho in the Apulian foreland is nearly flat at ˜30 km depth, consistent with previous P receiver functions results, and that the Hyblean crustal thickness is more complex, which can be understood in terms of the nature of the individual pieces of carbonate platform and pelagic sediments that make up the Hyblean platform. The lithospheric thicknesses range between 70-120 km beneath Apulia and 70-90 km beneath Sicily. The lithosphere of the forelands at each end of the Calabrian arc are continental in nature, buoyant compared to the subducting oceanic lithosphere and have previously been interpreted as mostly undeformed carbonate platforms. Our receiver function images also show evidence of lithospheric erosion and thinning close to Mt. Etna and Mt. Vulture, two volcanoes which have been associated with asthenospheric upwelling and mantle flow around of the sides the slab. We suggest that as the continental lithosphere resists being subducted it is being thermo-mechanically modified by toroidal flow around the edges of the subducting oceanic lithosphere of the Calabrian arc.

  5. Factor Analysis of People Rather than Variables: Q and Other Two-Mode Factor Analytic Models.

    ERIC Educational Resources Information Center

    Frederick, Brigitte N.

    Factor analysis attempts to study how different objects group together to form factors with the purposes of: (1) reducing the number of factorable entities (e.g., variables) with which the researcher needs to deal; (2) searching data for qualitative and quantitative differences; and (3) testing hypotheses (R. Gorsuch, 1983). While most factor…

  6. A Discourse Analytic Approach to Video Analysis of Teaching: Aligning Desired Identities with Practice

    ERIC Educational Resources Information Center

    Schieble, Melissa; Vetter, Amy; Meacham, Mark

    2015-01-01

    The authors present findings from a qualitative study of an experience that supports teacher candidates to use discourse analysis and positioning theory to analyze videos of their practice during student teaching. The research relies on the theoretical concept that learning to teach is an identity process. In particular, teachers construct and…

  7. Researcher Effects on Mortality Salience Research: A Meta-Analytic Moderator Analysis

    ERIC Educational Resources Information Center

    Yen, Chih-Long; Cheng, Chung-Ping

    2013-01-01

    A recent meta-analysis of 164 terror management theory (TMT) papers indicated that mortality salience (MS) yields substantial effects (r = 0.35) on worldview and self-esteem-related dependent variables (B. L. Burke, A. Martens, & E. H. Faucher, 2010). This study reanalyzed the data to explore the researcher effects of TMT. By cluster-analyzing…

  8. The Effect of Gender on Organizational Commitment of Teachers: A Meta Analytic Analysis

    ERIC Educational Resources Information Center

    Aydin, Ayhan; Sarier, Yilmaz; Uysal, Sengul

    2011-01-01

    The purpose of this study is to determine the effect of gender on the organizational commitment of teachers. In this respect, the levels of organizational commitment were also investigated with organizational commitment. Fifteen master and doctorate theses done between 2005-2009 were analyzed using meta analysis. At the end of the research study,…

  9. Black Boxes in Analytical Chemistry: University Students' Misconceptions of Instrumental Analysis

    ERIC Educational Resources Information Center

    Carbo, Antonio Domenech; Adelantado, Jose Vicente Gimeno; Reig, Francisco Bosch

    2010-01-01

    Misconceptions of chemistry and chemical engineering university students concerning instrumental analysis have been established from coordinated tests, tutorial interviews and laboratory lessons. Misconceptions can be divided into: (1) formal, involving specific concepts and formulations within the general frame of chemistry; (2)…

  10. The analysis of non-linear dynamic behavior (including snap-through) of postbuckled plates by simple analytical solution

    NASA Technical Reports Server (NTRS)

    Ng, C. F.

    1988-01-01

    Static postbuckling and nonlinear dynamic analysis of plates are usually accomplished by multimode analyses, although the methods are complicated and do not give straightforward understanding of the nonlinear behavior. Assuming single-mode transverse displacement, a simple formula is derived for the transverse load displacement relationship of a plate under in-plane compression. The formula is used to derive a simple analytical expression for the static postbuckling displacement and nonlinear dynamic responses of postbuckled plates under sinusoidal or random excitation. Regions with softening and hardening spring behavior are identified. Also, the highly nonlinear motion of snap-through and its effects on the overall dynamic response can be easily interpreted using the single-mode formula. Theoretical results are compared with experimental results obtained using a buckled aluminum panel, using discrete frequency and broadband point excitation. Some important effects of the snap-through motion on the dynamic response of the postbuckled plates are found.

  11. Rapid process development of chromatographic process using direct analysis in real time mass spectrometry as a process analytical technology tool.

    PubMed

    Yan, Binjun; Chen, Teng; Xu, Zhilin; Qu, Haibin

    2014-06-01

    The concept of quality by design (QbD) is widely applied in the process development of pharmaceuticals. However, the additional cost and time have caused some resistance about QbD implementation. To show a possible solution, this work proposed a rapid process development method, which used direct analysis in real time mass spectrometry (DART-MS) as a process analytical technology (PAT) tool for studying the chromatographic process of Ginkgo biloba L., as an example. The breakthrough curves were fast determined by DART-MS at-line. A high correlation coefficient of 0.9520 was found between the concentrations of ginkgolide A determined by DART-MS and HPLC. Based on the PAT tool, the impacts of process parameters on the adsorption capacity were discovered rapidly, which showed a decreased adsorption capacity with the increase of the flow rate. This work has shown the feasibility and advantages of integrating PAT into QbD implementation for rapid process development.

  12. Ion beam analysis and PD-MS as new analytical tools for quality control of pharmaceuticals: comparative study from fluphenazine in solid dosage forms.

    PubMed

    Nsouli, Bilal; Bejjani, Alice; Negra, Serge Della; Gardon, Alain; Thomas, Jean-Paul

    2010-09-01

    In order to evaluate the potential of accelerator based analytical techniques ((particle induced X-ray emission (PIXE), particle induced gamma-ray emission (PIGE), and particle desorption mass spectrometry (PD-MS)) for the analysis of commercial pharmaceutical products in their solid dosage form, the fluphenazine drug has been taken as a representative example. It is demonstrated that PIXE and PIGE are by far the best choice for quantification of the active ingredient (AI) (certification with 7% precision) from the reactions induced on its specific heteroatoms fluorine and sulfur using pellets made from original tablets. Since heteroatoms cannot be present in all types of drugs, the PD-MS technique, which makes easily the distinction between AI(s) and excipients, has been evaluated for the same material. It is shown that the quantification of AI is obtained via the detection of its protonated molecule. However, calibration curves have to be made from the secondary ion yield variations since matrix effects of various nature are characteristics of such mixtures of heterogeneous materials (including deposits from soluble components). From the analysis of solid tablets, (either transformed into pellets and even as received), it is strongly suggested that the physical state of the grains in the mixture is a crucial parameter in the ion emission and accordingly for the calibration curves. As a result of our specific (but not optimized) conditions the resulting precision is <17% with an almost linear range extending from 0.04 to 7.87 mg of AI in a tablet made under the manufacturer conditions (the commercial drug product is labeled at 5 mg).

  13. A Multi-facetted Visual Analytics Tool for Exploratory Analysis of Human Brain and Function Datasets

    PubMed Central

    Angulo, Diego A.; Schneider, Cyril; Oliver, James H.; Charpak, Nathalie; Hernandez, Jose T.

    2016-01-01

    Brain research typically requires large amounts of data from different sources, and often of different nature. The use of different software tools adapted to the nature of each data source can make research work cumbersome and time consuming. It follows that data is not often used to its fullest potential thus limiting exploratory analysis. This paper presents an ancillary software tool called BRAVIZ that integrates interactive visualization with real-time statistical analyses, facilitating access to multi-facetted neuroscience data and automating many cumbersome and error-prone tasks required to explore such data. Rather than relying on abstract numerical indicators, BRAVIZ emphasizes brain images as the main object of the analysis process of individuals or groups. BRAVIZ facilitates exploration of trends or relationships to gain an integrated view of the phenomena studied, thus motivating discovery of new hypotheses. A case study is presented that incorporates brain structure and function outcomes together with different types of clinical data. PMID:27601990

  14. Framework for Analytic Cognition (FAC): A Guide for Doing All-Source Intelligence Analysis

    DTIC Science & Technology

    2011-12-01

    humans as rational decision makers has been thoroughly discounted in the last decade. Recent research in neuroscience and cognitive psychology has...Intelligence and Counterintelligence, Vol. 18, No. 2, 2005, p. 206. 60 Moore, D.T. & Krizan, L. "Intelligence Analysis: Does NSA have what it Takes...SIGINT NSA Online TS/SCI Online Digital Yes COMINT Internet None N/A Unclassified Online Digital Yes Open Source STRATFOR Local information

  15. Analytical and Graphical Methods for the Analysis of Slopes in Rock Masses

    DTIC Science & Technology

    1980-03-01

    Properties of Nuclear Craters." The contract was negotiated on 16 June 1967. This report was prepared by Messrs. Hendron, Cording and Aiyer; and, was...80 4. GRAPHICAL SLOPE STABILITY ANALYSIS BY USE OF STEREONETS . 83 4.1 Properties of Spherical Projections .......... ... 83 4.1.1...FIGURES Page 2.1 Scalar Product of Two Vectors ............. . . 2.2 Cross Product of Two Vectors ....... ............... 8 2.3 Orinetation of a

  16. Nuclear analytical chemistry

    SciTech Connect

    Brune, D.; Forkman, B.; Persson, B.

    1984-01-01

    This book covers the general theories and techniques of nuclear chemical analysis, directed at applications in analytical chemistry, nuclear medicine, radiophysics, agriculture, environmental sciences, geological exploration, industrial process control, etc. The main principles of nuclear physics and nuclear detection on which the analysis is based are briefly outlined. An attempt is made to emphasise the fundamentals of activation analysis, detection and activation methods, as well as their applications. The book provides guidance in analytical chemistry, agriculture, environmental and biomedical sciences, etc. The contents include: the nuclear periodic system; nuclear decay; nuclear reactions; nuclear radiation sources; interaction of radiation with matter; principles of radiation detectors; nuclear electronics; statistical methods and spectral analysis; methods of radiation detection; neutron activation analysis; charged particle activation analysis; photon activation analysis; sample preparation and chemical separation; nuclear chemical analysis in biological and medical research; the use of nuclear chemical analysis in the field of criminology; nuclear chemical analysis in environmental sciences, geology and mineral exploration; and radiation protection.

  17. Imaging The Flat Slab Beneath The Sierras Pampeanas, Argentina, Using Receiver Function Analysis: Evidence For Overthickened Subducted Oceanic Crust

    NASA Astrophysics Data System (ADS)

    Gans, C.; Beck, S. L.; Zandt, G.; Gilbert, H. J.; Alvarado, P. M.; Linkimer, L.; Porter, R. C.

    2009-12-01

    The western margin of the South American continent between 30°and 32° S is characterized by the flat slab subduction of the ~43 Ma oceanic Nazca plate beneath the continental South American plate. Several arrays of broadband seismic instruments have been deployed in Chile and western Argentina to study this phenomenon (e.g., CHARGE, 2000-2002; SIEMBRA, 2007-2009; ESP, 2008-2010). The low angle subduction has prevented magmatism in the area since the late Miocene due to reduced mantle flow above the subducting slab, and spatially correlates with the formation of both thick-skinned (Sierras Pampeanas) and thin-skinned (Andean Precordillera) thrust belts within the region. In order to better constrain the crust and upper mantle structure in the transition region between flat slab and normal subduction to the south and east, we have calculated receiver functions (RFs) from teleseismic earthquakes. Using our dense SIEMBRA array, combined with the broader CHARGE and ESP arrays, we are able to image in detail the flat slab, which contains a distinct negative arrival (indicative of a low velocity zone) at the top of the flat slab, followed by a strong positive P-to-S conversion. While the exact causes of flat slab subduction continue to be debated, one overriding theme is the necessity of having an overthickened crust in order to increase the buoyancy of the subducting slab. In this region, the hotspot seamount chain of the Juan Fernandez Ridge (JFR) is thought to provide such a mechanism. Kopp et al. (2004), however, did not find overthickened crust in the offshore portion of the JFR, but rather moderately thick oceanic crust. Preliminary results from our receiver functions, compared with synthetic RFs containing either a normal (7 km) or an overthickened (17km) crust, indicate that the oceanic crust at the top of the slab (the low velocity zone) must be at least ~15 km thick. Our results support the idea of an overthickened crust in the subducted flat slab beneath

  18. Does anterior plating maintain cervical lordosis versus conventional fusion techniques? A retrospective analysis of patients receiving single-level fusions.

    PubMed

    Troyanovich, Stephan J; Stroink, Ann R; Kattner, Keith A; Dornan, Wayne A; Gubina, Irina

    2002-02-01

    A retrospective review of medical records and radiographs of patients receiving anterior cervical discectomy and fusion (ACDF) without anterior plating and with anterior plating was performed. The objective of the study was to determine whether a difference exists in cervical lordotic alignment between subjects undergoing single-level ACDF with and without anterior cervical plating instrumentation for symptomatic cervical disc disease. Collapse or settling of grafted bone into the vertebral endplates with resulting kyphotic deformity of the cervical spine is a commonly described complication of anterior discectomy and fusion. Despite the increasing use of instrumentation for the treatment of cervical spine injuries and degenerative conditions, little is known regarding lordotic alignment of the cervical spine in patients who receive plating instrumentation compared with conventional fusion without plating. Accumulating evidence suggests that plating is superior to non-plating techniques in patients with multiple level cervical disc lesions in regard to fusion, return to work rates, and complication rates; however, little is known about maintenance of lordotic curve alignment in single- and multiple-level procedures. Neutral lateral cervical radiographs of 57 patients who underwent single-level ACDF between 1994 and 1999 with anterior screw plates (n = 26), and conventional single-level fusion without anterior screw plates (n = 21) were retrospectively assessed. Measurements were made on weight-bearing lateral cervical radiographs to assess overall sagittal spinal alignment and intersegmental sagittal alignment at the surgical site before surgery, immediately after surgery, 4 to 12 weeks after surgery, and 12+ months after surgery. The average magnitude of overall lordosis measured between C2 and C7 decreased 4.2 degrees in the non-plated group, while being preserved in the plated group. This finding did not reach statistical significance in the long-term follow

  19. A theoretical analysis of the free vibrations of ring- and/or stringer-stiffened elliptical cylinders with arbitrary end conditions. Volume 1: Analytical derivation and applications

    NASA Technical Reports Server (NTRS)

    Boyd, D. E.; Rao, C. K. P.

    1973-01-01

    The derivation and application of a Rayleigh-Ritz modal vibration analysis are presented for ring and/or stringer stiffened noncircular cylindrical shells with arbitrary end conditions. Comparisons with previous results from experimental and analytical studies showed this method of analysis to be accurate for a variety of end conditions. Results indicate a greater effect of rings on natural frequencies than of stringers.

  20. Cryoplasty Versus Conventional Angioplasty in Femoropopliteal Arterial Recanalization: 3-Year Analysis of Reintervention-Free Survival by Treatment Received

    SciTech Connect

    Diaz, Maria Lourdes; Urtasun, Fermin Barberena, Javier; Aranzadi, Carlos; Guillen-Grima, Francisco; Bilbao, Jose Ignacio

    2011-10-15

    Purpose: To compare long-term efficacy of cryoplasty therapy versus conventional angioplasty in the treatment of peripheral arterial atherosclerotic stenosis on the basis of our 3-year clinical experience. Materials and Methods: From January 2006 to December 2008, a total of 155 patients with 192 lesions of the femoropopliteal sector were randomized to receive either cryoplasty or conventional balloon angioplasty. The primary study end point was lesion target patency. Follow-up with clinical evaluation of patient's symptoms, ankle-brachial index, and Doppler ultrasound was scheduled at 1, 6, 9, 12, 24, and 36 months. Results: For the cryoplasty group (n = 86), technical immediate success was achieved in 74.4% of lesions. Rate of significant dissection was 13.5% and rate of stent placement of 22%. In the long term, target lesion patency rate at 6 months was 59.4%, with rates of 55.9, 52.6, and 49.1% at 1, 2, and 3 years, respectively. For the conventional angioplasty group (n = 69), the immediate technical success rate was 83.7%. Rate of significant dissection was 19%, and rate of stent placement was 72.9%. Patency rates at 6 months and at 1, 2, and 3 years were 71.5, 61.2, 60, and 56%, respectively. Conclusion: Compared with conventional angioplasty, cryoplasty showed good immediate success rates with lower stent placement rates. During the 3-year follow-up, patency rates tended to equalize between the two modalities.

  1. [Analysis of Factors Influencing the Development of Hypomagnesemia in Patients Receiving Cetuximab Therapy for Head and Neck Cancer].

    PubMed

    Inose, Ryo; Takahashi, Katsuyuki; Nishikawa, Takeshi; Nagayama, Katsuya

    2015-01-01

    Cetuximab was approved in Japan as the only clinically available molecular targeted drug for the treatment of head and neck cancer. Hypomagnesemia associated with cetuximab is considered one of the most serious adverse events. However, the factors influencing the development of hypomagnesemia are not clear, although the drug was previously approved for the treatment of patients with colorectal cancer. Thus, we studied the factors involved in the development of hypomagnesemia in patients receiving cetuximab therapy for head and neck cancer. Patients' background data and laboratory values before starting cetuximab therapy did not affect the development of hypomagnesemia. Among patients who had never been treated with cisplatin (NT group), 36.4% developed hypomagnesemia. In contrast, all patients who had previously been treated with cisplatin (T group) developed hypomagnesemia (p=0.034). Magnesium is reabsorbed by transient receptor potential subfamily melastatin 6 (TRPM6) in the distal convoluted tubule. The expression level of TRPM6 is controlled by the epidermal growth factor (EGF) pathway. Cetuximab is an EGF receptor inhibitor and reduces the expression of TRPM6. Additionally, recent studies have shown that the expression of TRPM6 is reduced by cisplatin. Therefore, we considered that the serum magnesium level was cumulatively reduced by cetuximab and cisplatin. In conclusion, the T group was more likely to develop hypomagnesemia than the NT group, and therefore the serum magnesium level in the T group requires careful monitoring so that magnesium supplementation can be provided to patients when the level decreases.

  2. Evaluation of Models for Alternaria Brown Spot of Mandarin Under Mediterranean Conditions by Partial Receiver Operating Characteristic Curve Analysis.

    PubMed

    Bassimba, Daniel D M; Mira, Jose L; Vicent, Antonio

    2017-04-12

    Alternaria brown spot (ABS) is a serious fungal disease of mandarin in the Mediterranean Basin. Due to the rigorous fruit quality standards, models for ABS should avoid false negatives. Experiments were conducted with susceptible 'Fortune' and 'Nova' inoculated at different temperatures and leaf wetness durations, including interrupted periods. Effects of temperature and time elapsed after inoculation were also studied. Disease incidence data were fitted to generalized additive models and a generic infection model. Exposure of trap plants in affected orchards was used for model evaluation, including the Alter-Rater and a simple rule system (SRS). The predictive ability of the models was analyzed using the partial area under the receiver operating characteristic curve in the high-sensitivity range between 0.9 and 1. Postinoculation temperature had a significant effect on disease incidence, with maximum symptom expression after 30 h on Fortune and 60 h on Nova. ABS incidence did not increase after a leaf wetness interruption of 1 h on Nova and 2 h on Fortune. All the models evaluated had high false-positive rates on Fortune. Only the SRS showed a substantial strength of agreement in Nova, with a true-positive rate of 0.93 and false-positive rate of 0.16.

  3. Analytical Methods for Malachite Green : Completion Report : Malachite Green Analysis in Water.

    SciTech Connect

    Allen, John L.; Gofus, Jane E.; Meinertz, Jeffery R.

    1991-06-01

    Malachite green is a known teratogen and therefore its use is limited to nonfood fish under an Investigational New Animal Drug permit (INAD), number 2573. Although a charcoal adsorption column was developed to remove malachite green from hatchery water, INAD compliance requires that the malachite green residue concentrations in any effluent from hatcheries using the chemical be quantified. Therefore, we developed a method for the analysis of malachite green residues in water. Enrichment of the residues of malachite green in water on a diol column followed by High Performance Liquid Chromatographic (HPLC) analysis gives a minimum sensitivity of less than 10 ppb for the chemical. When combined with post-column oxidation using a lead oxide post-column reactor, the procedure can be used for the simultaneous analysis of malachite green in its leuco form, a decomposition product of the dye, as well as its chromatic form. Recovery of the leuco form is pH dependent and water samples should be adjusted to pH 6 to optimize recovery of this form. Water samples spiked with malachite green were concentrated on a diol column followed by elution with 0.05 M p-toluene sulfonic acid in methanol. The methanol elutes were analyzed by HPLC. Pond water samples spiked with malachite green and leuco malachite green yielded average recoveries of 95.4% for malachite green and 57.3% for leuco malachite green. Tap water samples spiked with the carbinol form of malachite green gave average recoveries of 98.6%. The method is very sensitive and is capable of detecting malachite green residues in water at less than 10 ppb. Fish culturists, who cannot find an effective replacement for malachite green, can utilize the method to ensure that their effluents comply with INAD regulations. 13 refs., 2 figs., 7 tabs.

  4. Double-sided Microfluidic Device for Speciation Analysis of Iron in Water Samples: Towards Greener Analytical Chemistry.

    PubMed

    Youngvises, Napaporn; Thanurak, Porapichcha; Chaida, Thanatcha; Jukmunee, Jaroon; Alsuhaimi, Awadh

    2015-01-01

    Microfluidics minimize the amounts of reagents and generate less waste. While microdevices are commonly single-sided, producing a substrate with microchannels on multiple surfaces would increase their usefulness. Herein, a polymethymethacrylate substrate incorporating microchannel structures on two sides was sandwiched between two polydimethylsiloxane sheets to create a multi-analysis device, which was used for the spectrophotometric analysis of the ferrous ion (Fe(2+)) and the ferric ion (Fe(3+)), by utilizing colorimetric detection. To monitor the signals from both channel networks, dual optical sensors were integrated into the system. The linear ranges for Fe(2+) and Fe(3+) analyses were 0.1 - 20 mg L(-1) (R(2) = 0.9988) and 1.0 - 40 mg L(-1) (R(2) = 0.9974), respectively. The detection limits for Fe(2+) and Fe(3+) were 0.1 and 0.5 mg L(-1), respectively. The percent recoveries of Fe(2+) and Fe(3+) were 93.5 - 104.3 with an RSD < 8%. The microdevice demonstrated capabilities for simultaneous analysis, low waste generation (7.2 mL h(-1)), and high sample throughput (180 h(-1)), making it ideal for greener analytical chemistry applications.

  5. Development of Analytical Protocols For Organics and Isotopes Analysis on the 2009 MARS Science Laboratory.

    NASA Technical Reports Server (NTRS)

    Mahaffy, P. R.

    2006-01-01

    The Mars Science Laboratory, under development for launch in 2009, is designed explore and quantitatively asses a local region on Mars as a potential habitat for present or past life. Its ambitious goals are to (1) assess the past or present biological potential of the target environment, (2) to characterize the geology and geochemistry at the MSL landing site, and (3) to investigate planetary processes that influence habitability. The planned capabilities of the rover payload will enable a comprehensive search for organic molecules, a determination of definitive mineralogy of sampled rocks and fines, chemical and isotopic analysis of both atmospheric and solid samples, and precision isotope measurements of several volatile elements. A range of contact and remote surface and subsurface survey tools will establish context for these measurements and will facilitate sample identification and selection. The Sample Analysis at Mars (SAM) suite of MSL addresses several of the mission's core measurement goals. It includes a gas chromatograph, a mass spectrometer, and a tunable laser spectrometer. These instruments will be designed to analyze either atmospheric samples or gases extracted from solid phase samples such as rocks and fines. We will describe the range of measurement protocols under development and study by the SAM engineering and science teams for use on the surface of Mars.

  6. SASfit: a tool for small-angle scattering data analysis using a library of analytical expressions

    PubMed Central

    Breßler, Ingo; Kohlbrecher, Joachim; Thünemann, Andreas F.

    2015-01-01

    SASfit is one of the mature programs for small-angle scattering data analysis and has been available for many years. This article describes the basic data processing and analysis workflow along with recent developments in the SASfit program package (version 0.94.6). They include (i) advanced algorithms for reduction of oversampled data sets, (ii) improved confidence assessment in the optimized model parameters and (iii) a flexible plug-in system for custom user-provided models. A scattering function of a mass fractal model of branched polymers in solution is provided as an example for implementing a plug-in. The new SASfit release is available for major platforms such as Windows, Linux and MacOS. To facilitate usage, it includes comprehensive indexed documentation as well as a web-based wiki for peer collaboration and online videos demonstrating basic usage. The use of SASfit is illustrated by interpretation of the small-angle X-ray scattering curves of monomodal gold nanoparticles (NIST reference material 8011) and bimodal silica nanoparticles (EU reference material ERM-FD-102). PMID:26500467

  7. Space Trajectory Error Analysis Program (STEAP) for halo orbit missions. Volume 1: Analytic and user's manual

    NASA Technical Reports Server (NTRS)

    Byrnes, D. V.; Carney, P. C.; Underwood, J. W.; Vogt, E. D.

    1974-01-01

    Development, test, conversion, and documentation of computer software for the mission analysis of missions to halo orbits about libration points in the earth-sun system is reported. The software consisting of two programs called NOMNAL and ERRAN is part of the Space Trajectories Error Analysis Programs (STEAP). The program NOMNAL targets a transfer trajectory from Earth on a given launch date to a specified halo orbit on a required arrival date. Either impulsive or finite thrust insertion maneuvers into halo orbit are permitted by the program. The transfer trajectory is consistent with a realistic launch profile input by the user. The second program ERRAN conducts error analyses of the targeted transfer trajectory. Measurements including range, doppler, star-planet angles, and apparent planet diameter are processed in a Kalman-Schmidt filter to determine the trajectory knowledge uncertainty. Execution errors at injection, midcourse correction and orbit insertion maneuvers are analyzed along with the navigation uncertainty to determine trajectory control uncertainties and fuel-sizing requirements. The program is also capable of generalized covariance analyses.

  8. Gray Matter Features of Reading Disability: A Combined Meta-Analytic and Direct Analysis Approach1234

    PubMed Central

    Berninger, Virginia W.; Gebregziabher, Mulugeta; Tsu, Loretta

    2016-01-01

    Abstract Meta-analysis of voxel-based morphometry dyslexia studies and direct analysis of 293 reading disability and control cases from six different research sites were performed to characterize defining gray matter features of reading disability. These analyses demonstrated consistently lower gray matter volume in left posterior superior temporal sulcus/middle temporal gyrus regions and left orbitofrontal gyrus/pars orbitalis regions. Gray matter volume within both of these regions significantly predicted individual variation in reading comprehension after correcting for multiple comparisons. These regional gray matter differences were observed across published studies and in the multisite dataset after controlling for potential age and gender effects, and despite increased anatomical variance in the reading disability group, but were not significant after controlling for total gray matter volume. Thus, the orbitofrontal and posterior superior temporal sulcus gray matter findings are relatively reliable effects that appear to be dependent on cases with low total gray matter volume. The results are considered in the context of genetics studies linking orbitofrontal and superior temporal sulcus regions to alleles that confer risk for reading disability. PMID:26835509

  9. Off-target effects and clinical outcome in metastatic colorectal cancer patients receiving regorafenib: The TRIBUTE analysis

    PubMed Central

    Giampieri, Riccardo; Prete, Michela del; Prochilo, Tiziana; Puzzoni, Marco; Pusceddu, Valeria; Pani, Fabiana; Maccaroni, Elena; Mascia, Roberta; Baleani, Maria Giuditta; Meletani, Tania; Berardi, Rossana; Lanzillo, Anna Maria; Mariotti, Stefano; Zaniboni, Alberto; Cascinu, Stefano; Scartozzi, Mario

    2017-01-01

    Regorafenib is an orally administered multikinase inhibitor indicated for the treatment of heavily pretreated metastatic colorectal cancer patients with good performance status, albeit less than 50% treated patients achieve disease stabilisation or better at the first radiological evaluation. In addition to that a particularly broad spectrum of toxicities (experienced as G3 or more NCI CTCAE graded by 50% of patients treated) have led to reconsider its widespread use in the majority of patients. We retrospectively collected data about the magnitude of off-target effects experienced during the first 8-weeks of regorafenib monotherapy and analysed their correlation with overall survival, progression free survival and disease control rate. Our findings suggest that skin rash (Exp (B): 0.52, p = 0.0133) or hypothyroidism (Exp (B): 0.11, p = 0.0349) were significantly correlated with improved overall survival at multivariate regression analysis. It was also demonstrated a statistically significant role of diarrhea as predictor of improved survival but its independent prognostic role was lost at multivariate analysis (Exp (B): 0.63, p = 0.162). This is the first analysis showing a potential correlation between the onset of these forms of side effects and regorafenib efficacy, however sample size limitations and the retrospective nature of our analysis prevent us from drawing definitive conclusions. PMID:28378839

  10. Off-target effects and clinical outcome in metastatic colorectal cancer patients receiving regorafenib: The TRIBUTE analysis.

    PubMed

    Giampieri, Riccardo; Prete, Michela Del; Prochilo, Tiziana; Puzzoni, Marco; Pusceddu, Valeria; Pani, Fabiana; Maccaroni, Elena; Mascia, Roberta; Baleani, Maria Giuditta; Meletani, Tania; Berardi, Rossana; Lanzillo, Anna Maria; Mariotti, Stefano; Zaniboni, Alberto; Cascinu, Stefano; Scartozzi, Mario

    2017-04-05

    Regorafenib is an orally administered multikinase inhibitor indicated for the treatment of heavily pretreated metastatic colorectal cancer patients with good performance status, albeit less than 50% treated patients achieve disease stabilisation or better at the first radiological evaluation. In addition to that a particularly broad spectrum of toxicities (experienced as G3 or more NCI CTCAE graded by 50% of patients treated) have led to reconsider its widespread use in the majority of patients. We retrospectively collected data about the magnitude of off-target effects experienced during the first 8-weeks of regorafenib monotherapy and analysed their correlation with overall survival, progression free survival and disease control rate. Our findings suggest that skin rash (Exp (B): 0.52, p = 0.0133) or hypothyroidism (Exp (B): 0.11, p = 0.0349) were significantly correlated with improved overall survival at multivariate regression analysis. It was also demonstrated a statistically significant role of diarrhea as predictor of improved survival but its independent prognostic role was lost at multivariate analysis (Exp (B): 0.63, p = 0.162). This is the first analysis showing a potential correlation between the onset of these forms of side effects and regorafenib efficacy, however sample size limitations and the retrospective nature of our analysis prevent us from drawing definitive conclusions.

  11. Impact of analysing continuous outcomes using final values, change scores and analysis of covariance on the performance of meta-analytic methods: a simulation study.

    PubMed

    McKenzie, Joanne E; Herbison, G Peter; Deeks, Jonathan J

    2016-12-01

    When meta-analysing intervention effects calculated from continuous outcomes, meta-analysts often encounter few trials, with potentially a small number of participants, and a variety of trial analytical methods. It is important to know how these factors affect the performance of inverse-variance fixed and DerSimonian and Laird random effects meta-analytical methods. We examined this performance using a simulation study. Meta-analysing estimates of intervention effect from final values, change scores, ANCOVA or a random mix of the three yielded unbiased estimates of pooled intervention effect. The impact of trial analytical method on the meta-analytic performance measures was important when there was no or little heterogeneity, but was of little relevance as heterogeneity increased. On the basis of larger than nominal type I error rates and poor coverage, the inverse-variance fixed effect method should not be used when there are few small trials. When there are few small trials, random effects meta-analysis is preferable to fixed effect meta-analysis. Meta-analytic estimates need to be cautiously interpreted; type I error rates will be larger than nominal, and confidence intervals will be too narrow. Use of trial analytical methods that are more efficient in these circumstances may have the unintended consequence of further exacerbating these issues. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd.

  12. Crustal structure beneath the High Lava Plains of eastern Oregon and surrounding regions from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Eagar, Kevin C.; Fouch, Matthew J.; James, David E.; Carlson, Richard W.

    2011-02-01

    We analyze teleseismic P-to-S receiver functions to image crustal structure beneath the High Lava Plains (HLP) of eastern Oregon and surrounding regions. Coverage from 206 broadband seismic stations provides the first opportunity to resolve variations in crustal composition, thickness, and heterogeneity on scales of a few km in depth and tens of km laterally across the HLP region. We utilize both H - κ stacking and a new Gaussian-weighted common conversion point stacking technique. We find crust that is ≥40 km thick beneath the Cascades, Idaho Batholith, and Owyhee Plateau and thinner (˜31 km) crust beneath the HLP and northern Great Basin. Low Poisson's ratios of ˜0.240 characterize the granitic crust beneath the Idaho Batholith, while the Owyhee Plateau exhibits values of ˜0.270, typical of average continental crust. The Owyhee Plateau is a thick simple crustal block with distinct edges at depth. The western HLP exhibits high average values of 0.304, typical for regions of widespread basaltic volcanism. Combined with other geological and geophysical observations, the areas of abnormally high Poisson's ratios (˜0.320) and low-velocity zones in the crust beneath north-central and southern Oregon are consistent with the presence of partial melt on either side of the HLP trend, suggesting a central zone where crustal melts have drained to the surface, perhaps enabled by the Brothers Fault Zone. Thicker crust and an anomalous N-S band of low Poisson's ratios (˜0.252) skirting the Steens Mountain escarpment is consistent with residuum from a midcrustal magma source of the massive flood basalts, supporting the view of extensive mafic underplating and intraplating of the crust from Cenozoic volcanism.

  13. An Analysis of the Origins, Subjects, and Awards Received for Presentations at the Annual IASG Conferences (2009-2013).

    PubMed

    Soni, Subhash; Sahni, Peush; Nundy, Samiran

    2015-12-01

    s presented at scientific meetings are important for making ongoing research more widely known and may also reflect the quality of the parent institution's standard of patient care. We analyzed the abstracts presented at the annual meetings of IASG for the past 5 years for (i) medium of presentation (oral/poster/videos), (ii) subjects discussed, (iii) institution of origin, (iv) whether a prospective/ retrospective study or a case report, (v) changing trends, and (vi) awards received. Of the 1340 abstracts analyzed, there were 18.5 % oral, 74.9 % posters, and 6.5 % videos presented from 205 in 2009 to 388 in 2012. The main organs discussed were the liver (19.3 %) pancreas (18.8 %), and biliary system (14.4 %). Sixty percent was from the private sector with Sir Ganga Ram, SGRH (95) and the Apollo Hospital, New Delhi (60), being the most prolific. From public institutes, the abstracts were predominantly from PGIMER, Chandigarh (39) and GB Pant Hospital (37). Thirty-three percent was from DNB and 25 % from M.Ch GI Surgery centres and 42 % was from others (most of these were as posters). There were 1016 (75.8 %) prospective/retrospective studies and 324 (24.2 %) case reports. Presentations, especially those related to liver transplantation, showed an increase. The main awards were won by SGRH (8); AIIMS, New Delhi (7); and JIPMER, Puducherry (6). Over the last 5 years, abstracts presented at the IASG have increased in number especially those dealing with the hepato-pancreatico-biliary system and liver transplantation. Most presentations were from "academic" departments, and similar analyses may inform us where we are heading and stimulate healthy competition.

  14. Crustal thickness and VP/ VS variations in the Grenville orogen (Ontario, Canada) from analysis of teleseismic receiver functions

    NASA Astrophysics Data System (ADS)

    Eaton, David W.; Dineva, Savka; Mereu, Robert

    2006-06-01

    We have developed a simple semblance-weighted stacking technique to estimate crustal thickness and average VP/ VS ratio using teleseismic receiver functions. We have applied our method to data from 32 broadband seismograph stations that cover a 700 × 400 km 2 region of the Grenville orogen, a 1.2-0.98 Ga Himalayan-scale collisional belt in eastern North America. Our seismograph network partly overlaps with L ITHOPROBE and other crustal refraction surveys. In 8 out of 9 cases where a crustal-refraction profile passes within 30 km of a seismograph station, the two independent crustal thickness estimates agree to within 7%. Our regional crustal-thickness model, constructed using both teleseismic and refraction observations, ranges between 34.0 and 52.4 km. Crustal-thickness trends show a strong correlation with geological belts, but do not correlate with surface topography and are far in excess of relief required to maintain local isostatic equilibrium. The thickest crust (52.4 ± 1.7 km) was found at a station located within the 1.1 Ga mid-continent (failed) rift. The Central Gneiss Belt, which contains rocks exhumed from deep levels of the crust, is characterized by VP/ VS ranging from 1.78 to 1.85. In other parts of the Grenville orogen, VP/ VS is found to be generally less than 1.80. The thinnest crust (34.5-37.0 km) occurs northeast of the 0.7 Ga Ottawa-Bonnechere graben and correlates with areas of high intraplate seismicity.

  15. Electromagnetic interference of cardiac rhythmic monitoring devices to radio frequency identification: analytical analysis and mitigation methodology.

    PubMed

    Ogirala, Ajay; Stachel, Joshua R; Mickle, Marlin H

    2011-11-01

    Increasing density of wireless communication and development of radio frequency identification (RFID) technology in particular have increased the susceptibility of patients equipped with cardiac rhythmic monitoring devices (CRMD) to environmental electro magnetic interference (EMI). Several organizations reported observing CRMD EMI from different sources. This paper focuses on mathematically analyzing the energy as perceived by the implanted device, i.e., voltage. Radio frequency (RF) energy transmitted by RFID interrogators is considered as an example. A simplified front-end equivalent circuit of a CRMD sensing circuitry is proposed for the analysis following extensive black-box testing of several commercial pacemakers and implantable defibrillators. After careful understanding of the mechanics of the CRMD signal processing in identifying the QRS complex of the heart-beat, a mitigation technique is proposed. The mitigation methodology introduced in this paper is logical in approach, simple to implement and is therefore applicable to all wireless communication protocols.

  16. Interventions to reduce sexual prejudice: a study-space analysis and meta-analytic review.

    PubMed

    Bartoş, Sebastian E; Berger, Israel; Hegarty, Peter

    2014-01-01

    Sexual prejudice is an important threat to the physical and mental well-being of lesbians, gay men, and bisexual people. Therefore, we reviewed the effectiveness of interventions designed to reduce such prejudice. A study-space analysis was performed on published and unpublished papers from all over the world to identify well-studied and underexplored issues. Most studies were conducted with North American undergraduates and were educational in nature. Dissertations were often innovative and well designed but were rarely published. We then performed meta-analyses on sets of comparable studies. Education, contact with gay people, and combining contact with education had a medium-size effect on several measures of sexual prejudice. The manipulation of social norms was effective in reducing antigay behavior. Other promising interventions, such as the use of entertainment media to promote tolerance, need further investigation. More research is also needed on populations other than American students, particularly groups who may have higher levels of sexual prejudice.

  17. Objective analysis of preparations in dental training: development of analytical software.

    PubMed

    Hey, Jeremias; Kupfer, Philipp; Urbannek, Michael; Beuer, Florian

    2013-01-01

    Objective analysis of the quality of a stump preparation by conventional methods is complex and expensive. In this regard digitalization has created new possibilities. The high resolution of modern scanners permits visual representation of the most minute preparation parameters. Virtual rulers permit measurement of distances in many construction programs; however, the use of such measuring instruments is too time-consuming for scientific studies. The computer program presented here permits measurement of the preparation angle, calculation of the width of the preparation margin, and determination of the horizontal path of the preparation shoulder. It runs on the Windows XP operating system independently of a CAD construction program. The program analyzes datasets in the STL file format.

  18. Analytical simulation of water system capacity reliability, 1. Modified frequency-duration analysis

    NASA Astrophysics Data System (ADS)

    Hobbs, Benjamin F.; Beim, Gina K.

    1988-09-01

    The problem addressed is the computation of the unavailability and expected unserved demand of a water supply system having random demand, finished water storage, and unreliable capacity components. Examples of such components include pumps, treatment plants, and aqueducts. Modified frequency-duration analysis estimates these reliability statistics by, first, calculating how often demand exceeds available capacity and, second, comparing the amount of water in storage with how long such capacity deficits last. This approach builds upon frequency-duration methods developed by the power industry for analyzing generation capacity deficits. Three versions of the frequency-duration approach are presented. Two yield bounds to system unavailability and unserved demand and the third gives an estimate of their true values between those bounds.

  19. Analytical Microscopy

    SciTech Connect

    Not Available

    2006-06-01

    In the Analytical Microscopy group, within the National Center for Photovoltaic's Measurements and Characterization Division, we combine two complementary areas of analytical microscopy--electron microscopy and proximal-probe techniques--and use a variety of state-of-the-art imaging and analytical tools. We also design and build custom instrumentation and develop novel techniques that provide unique capabilities for studying materials and devices. In our work, we collaborate with you to solve materials- and device-related R&D problems. This sheet summarizes the uses and features of four major tools: transmission electron microscopy, scanning electron microscopy, the dual-beam focused-ion-beam workstation, and scanning probe microscopy.

  20. Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis

    PubMed Central

    Jaime-Pérez, José Carlos; García-Arellano, Gisela; Méndez-Ramírez, Nereida; González-Llano, Óscar; Gómez-Almaguer, David

    2015-01-01

    Objective By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns. Methods Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns. Women with Hb <11.0 g/dL and newborns with cord Hb <13.0 g/dL were classified as anemic. A serum ferritin <12.0 μg/L in women and a cord blood serum ferritin <35.0 μg/L were considered to reflect empty iron stores. Receiver operating characteristic curve analysis was applied to select the cut-off points that better reflected iron stores. Results The Hb cut-off point selected by receiver operating characteristic curve analysis in women was <11.5 g/dL (sensitivity: 60.82, specificity: 53.33%, Youden Index: 0.450). Most of the newborns had normal Hb which precluded this analysis. Maternal Hb <11.0 g/dL was the cut-off point that best reflected iron deficiency anemia in newborns (sensitivity: 55.88%, specificity: 57.24%, Youden Index: 0.217). The best cut-off point of maternal serum ferritin to reflect empty iron stores in newborns was <6.0 μg/L (sensitivity: 76.47%, specificity: 31.58%, Youden Index: 0.200). Conclusion Hemoglobin concentration performed poorly to detect iron deficiency anemia in women at term with high risk for iron deficiency and their newborns. PMID:26041420

  1. Receiving social support online: an analysis of a computer-mediated support group for individuals living with irritable bowel syndrome.

    PubMed

    Coulson, Neil S

    2005-12-01

    In recent years, the rapid expansion in Internet access and computer-mediated communication has fostered new opportunities for individuals with health-related concerns to participate in supportive communication within a network of individuals dealing with similar issues. The aim of this study was to examine the nature of socially supportive communication that took place within a computer-mediated support network for individuals affected by irritable bowel syndrome. Using deductive thematic analysis, 572 posted messages were examined with reference to five main categories of social support (i.e., emotional, esteem, information, network, and tangible assistance). The analysis suggests that the primary function of this group was the communication of informational support, notably within the areas of symptom interpretation, illness management, and interaction with health care professionals.

  2. An attributional analysis of reactions to poverty: the political ideology of the giver and the perceived morality of the receiver.

    PubMed

    Weiner, Bernard; Osborne, Danny; Rudolph, Udo

    2011-05-01

    An attributional analysis of reactions to poverty is presented. The article begins by discussing the perceived causes of poverty and their taxonomic properties (locus, stability, and controllability). One antecedent of causal beliefs, political ideology, is then examined in detail, followed by a review of the effects of causal beliefs on emotions and behavior. It is contended that helping the poor is a moral issue, but the moral evaluation concerns the targeted recipient of aid rather than the potential help giver. Persons perceived as responsible for their plight, a dominant construal for conservatives, elicit anger and neglect. In contrast, those seen as not responsible for their financial hardship, an outlook predominantly endorsed by liberals, arouse sympathy and help giving. Sympathy is the most important proximal determinant of aid. This analysis is extended to reactions to achievement failure, abortion, and rape. Policy implications are also examined.

  3. High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum

    PubMed Central

    Jenkinson, Carl; Adams, John S.; Stewart, Paul M.; Hewison, Martin; Keevil, Brian G.

    2016-01-01

    Recent studies suggest that vitamin D-deficiency is linked to increased risk of common human health problems. To define vitamin D ‘status’ most routine analytical methods quantify one particular vitamin D metabolite, 25-hydroxyvitamin D3 (25OHD3). However, vitamin D is characterized by complex metabolic pathways, and simultaneous measurement of multiple vitamin D metabolites may provide a more accurate interpretation of vitamin D status. To address this we developed a high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyse multiple vitamin D analytes, with particular emphasis on the separation of epimer metabolites. A supportive liquid-liquid extraction (SLE) and LC-MS/MS method was developed to quantify 10 vitamin D metabolites as well as separation of an interfering 7α-hydroxy-4-cholesten-3-one (7αC4) isobar (precursor of bile acid), and validated by analysis of human serum samples. In a cohort of 116 healthy subjects, circulating concentrations of 25-hydroxyvitamin D3 (25OHD3), 3-epi-25-hydroxyvitamin D3 (3-epi-25OHD3), 24,25-dihydroxyvitamin D3 (24R,25(OH)2D3), 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3), and 25-hydroxyvitamin D2 (25OHD2) were quantifiable using 220 μl of serum, with 25OHD3 and 24R,25(OH)2D3 showing significant seasonal variations. This high-throughput LC-MS/MS method provides a novel strategy for assessing the impact of vitamin D on human health and disease. PMID:26874878

  4. High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum.

    PubMed

    Jenkinson, Carl; Taylor, Angela E; Hassan-Smith, Zaki K; Adams, John S; Stewart, Paul M; Hewison, Martin; Keevil, Brian G

    2016-03-01

    Recent studies suggest that vitamin D-deficiency is linked to increased risk of common human health problems. To define vitamin D 'status' most routine analytical methods quantify one particular vitamin D metabolite, 25-hydroxyvitamin D3 (25OHD3). However, vitamin D is characterized by complex metabolic pathways, and simultaneous measurement of multiple vitamin D metabolites may provide a more accurate interpretation of vitamin D status. To address this we developed a high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyse multiple vitamin D analytes, with particular emphasis on the separation of epimer metabolites. A supportive liquid-liquid extraction (SLE) and LC-MS/MS method was developed to quantify 10 vitamin D metabolites as well as separation of an interfering 7α-hydroxy-4-cholesten-3-one (7αC4) isobar (precursor of bile acid), and validated by analysis of human serum samples. In a cohort of 116 healthy subjects, circulating concentrations of 25-hydroxyvitamin D3 (25OHD3), 3-epi-25-hydroxyvitamin D3 (3-epi-25OHD3), 24,25-dihydroxyvitamin D3 (24R,25(OH)2D3), 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3), and 25-hydroxyvitamin D2 (25OHD2) were quantifiable using 220μL of serum, with 25OHD3 and 24R,25(OH)2D3 showing significant seasonal variations. This high-throughput LC-MS/MS method provides a novel strategy for assessing the impact of vitamin D on human health and disease.

  5. Analytical development of disturbed matrix eigenvalue problem applied to mixed convection stability analysis in Darcy media

    NASA Astrophysics Data System (ADS)

    Hamed, Haikel Ben; Bennacer, Rachid

    2008-08-01

    This work consists in evaluating algebraically and numerically the influence of a disturbance on the spectral values of a diagonalizable matrix. Thus, two approaches will be possible; to use the theorem of disturbances of a matrix depending on a parameter, due to Lidskii and primarily based on the structure of Jordan of the no disturbed matrix. The second approach consists in factorizing the matrix system, and then carrying out a numerical calculation of the roots of the disturbances matrix characteristic polynomial. This problem can be a standard model in the equations of the continuous media mechanics. During this work, we chose to use the second approach and in order to illustrate the application, we choose the Rayleigh-Bénard problem in Darcy media, disturbed by a filtering through flow. The matrix form of the problem is calculated starting from a linear stability analysis by a finite elements method. We show that it is possible to break up the general phenomenon into other elementary ones described respectively by a disturbed matrix and a disturbance. A good agreement between the two methods was seen. To cite this article: H.B. Hamed, R. Bennacer, C. R. Mecanique 336 (2008).

  6. A novel four-dimensional analytical approach for analysis of complex samples.

    PubMed

    Stephan, Susanne; Jakob, Cornelia; Hippler, Jörg; Schmitz, Oliver J

    2016-05-01

    A two-dimensional LC (2D-LC) method, based on the work of Erni and Frei in 1978, was developed and coupled to an ion mobility-high-resolution mass spectrometer (IM-MS), which enabled the separation of complex samples in four dimensions (2D-LC, ion mobility spectrometry (IMS), and mass spectrometry (MS)). This approach works as a continuous multiheart-cutting LC system, using a long modulation time of 4 min, which allows the complete transfer of most of the first - dimension peaks to the second - dimension column without fractionation, in comparison to comprehensive two-dimensional liquid chromatography. Hence, each compound delivers only one peak in the second dimension, which simplifies the data handling even when ion mobility spectrometry as a third and mass spectrometry as a fourth dimension are introduced. The analysis of a plant extract from Ginkgo biloba shows the separation power of this four-dimensional separation method with a calculated total peak capacity of more than 8700. Furthermore, the advantage of ion mobility for characterizing unknown compounds by their collision cross section (CCS) and accurate mass in a non-target approach is shown for different matrices like plant extracts and coffee. Graphical abstract Principle of the four-dimensional separation.

  7. Experimental testing and analytical analysis of a plastic panel heat exchanger for greenhouse heating

    SciTech Connect

    Olszewski, M.; Thomas, J.F.

    1980-02-01

    The performance of a plastic panel-type heat exchanger, suitable for greenhouse heating using low-grade (25 to 60/sup 0/C water) power plant reject heat, was investigated theoretically and experimentally. The theoretical analysis showed that a plastic panel heat exchanger would have an overall heat transfer coefficient, U/sub 0/, of about 18 w/m/sup 2/-/sup 0/C compared to about 12 w/m/sup 2/-/sup 0/C for a fin-tube heat exchanger, under typical greenhouse conditions. Furthermore the plastic heat exchanger would require less fan power due to reduced air pressure losses. The experimental data revealed a similar functional relationship for U/sub 0/ and air flow when compared with the theoretical calculations, however the experimental values of U/sub 0/ were consistently larger by 20 to 30%. It was concluded that a properly designed plastic heat exchanger can compete with metal fin tube type exchangers on a performance basis, but the plastic heat exchangers are 3 to 4 times larger by volume. However, because of the lower cost of plastic, a substantial cost reduction is expected. It appears that further study, examining heat exchanger lifetime, performance and costs, is warranted.

  8. Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans.

    PubMed

    Gillis, Richard B; Adams, Gary G; Besong, David T M; Machová, Eva; Ebringerová, Anna; Rowe, Arthur J; Harding, Stephen E; Patel, Trushar R

    2017-04-01

    Polysaccharides, the most abundant biopolymers, are required for a host of activities in lower organisms, animals, and plants. Their solution characterization is challenging due to their complex shape, heterogeneity, and size. Here, recently developed data analysis approaches were applied for traditional sedimentation equilibrium and velocity methods in order to investigate the molar mass distribution(s) of a subtype of polysaccharide, namely, mannans from four Candida spp. The molecular weight distributions of these mannans were studied using two recently developed equilibrium approaches: SEDFIT-MSTAR and MULTISIG, resulting in corroboratory distribution profiles. Additionally, sedimentation velocity data for all four mannans, analyzed using ls-g*(s) and Extended Fujita approaches, suggest that two of the fungal mannans (FM-1 and FM-3) have a unimodal distribution of molecular species whereas two others (FM-2 and FM-4) displayed bi-modal and broad distributions, respectively: this demonstrates considerable molecular heterogeneity in these polysaccharides, consistent with previous observations of mannans and polysaccharides in general. These methods not only have applications for the characterization of mannans but for other biopolymers such as polysaccharides, DNA, and proteins (including intrinsically disordered proteins).

  9. Paper-based analytical device for electrochemical flow-injection analysis of glucose in urine.

    PubMed

    Lankelma, Jan; Nie, Zhihong; Carrilho, Emanuel; Whitesides, George M

    2012-05-01

    This article describes a new design for a paper-based electrochemical system for flow-injection analysis. Capillary wicking facilitates a gravity-driven flow of buffer solution continuously through paper and nitrocellulose, from a buffer reservoir at one end of the device to a sink at the other. A difference in height between the reservoir and the sink leads to a continuous and constant flow. The nitrocellulose lies horizontally on a working electrode, which consists of a thin platinum layer deposited on a solid support. The counter and reference electrodes are strategically positioned upstream in the buffer reservoir. A simple pipetting device was developed for reliable application of (sub)microliter volumes of sample without the need of commercial micropipets; this device did not damage the nitrocellulose membrane. Demonstration of the system for the determination of the concentration of glucose in urine resulted in a noninvasive, quantitative assay that could be used for diagnosis and monitoring of diabetes. This method does not require disposable test strips, with enzyme and electrodes, that are thrown away after each measurement. Because of its low cost, this system could be used in medical environments that are resource-limited.

  10. Mode analysis for a microwave driven plasma discharge: A comparison between analytical and numerical results

    NASA Astrophysics Data System (ADS)

    Szeremley, Daniel; Mussenbrock, Thomas; Brinkmann, Ralf Peter; Zimmermanns, Marc; Rolfes, Ilona; Eremin, Denis; Ruhr-University Bochum, Theoretical Electrical Engineering Team; Ruhr-University Bochum, Institute of Microwave Systems Team

    2015-09-01

    The market shows in recent years a growing demand for bottles made of polyethylene terephthalate (PET). Therefore, fast and efficient sterilization processes as well as barrier coatings to decrease gas permeation are required. A specialized microwave plasma source - referred to as the plasmaline - has been developed to allow for depositing thin films of e.g. silicon oxid on the inner surface of such PET bottles. The plasmaline is a coaxial waveguide combined with a gas-inlet which is inserted into the empty bottle and initiates a reactive plasma. To optimize and control the different surface processes, it is essential to fully understand the microwave power coupling to the plasma and the related heating of electrons inside the bottle and thus the electromagnetic wave propagation along the plasmaline. In this contribution, we present a detailed dispersion analysis based on a numerical approach. We study how modes of guided waves are propagating under different conditions, if at all. The authors gratefully acknowledge the financial support of the German Research Foundation (DFG) within the framework of the collaborative research centre TRR87.

  11. Analytical constraints for the analysis of human cell line secretomes by shotgun proteomics.

    PubMed

    Malard, Véronique; Chardan, Laetitia; Roussi, Stamatiki; Darolles, Carine; Sage, Nicole; Gaillard, Jean-Charles; Armengaud, Jean

    2012-01-04

    Human cell line secretome represents a valuable source of therapeutic targets and candidate biomarkers. Secreted proteins found in biological fluids or culture media are by essence highly diluted. Secretome investigation with proteomic approaches is hardly compatible with the high content of proteins found in complete cell culture media. Therefore, many studies are currently done with media containing few or no protein. Such conditions may perturb cell metabolism and proliferation. Here, we compared seventeen different compositions of culture media for the human bronchial epithelial BEAS-2B cell line. Cell viability, proliferation rate and initial protein charge were systematically compared. We have shown that an important difficulty for the proteomic analysis is due to the presence of detergents such as Pluronic F-68 which hinders peptide mass spectrometry. The high glucose containing DMEM medium which is free of proteins was shown to preserve a good viability and proliferation of cells. With this conditioning medium, we identified 81 extracellular proteins in the secretome of BEAS-2B cells. Moreover, to illustrate this approach, we exposed BEAS-2B cells to a low toxic dose of CoCl(2,) and found 24 extracellular proteins modulated by cobalt. This study highlights the possible contribution of such proteomic approach in the field of toxicology.

  12. Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis

    PubMed Central

    2013-01-01

    Venous abnormalities contribute to the pathophysiology of several neurological conditions. This paper reviews the literature regarding venous abnormalities in multiple sclerosis (MS), leukoaraiosis, and normal-pressure hydrocephalus (NPH). The review is supplemented with hydrodynamic analysis to assess the effects on cerebrospinal fluid (CSF) dynamics and cerebral blood flow (CBF) of venous hypertension in general, and chronic cerebrospinal venous insufficiency (CCSVI) in particular. CCSVI-like venous anomalies seem unlikely to account for reduced CBF in patients with MS, thus other mechanisms must be at work, which increase the hydraulic resistance of the cerebral vascular bed in MS. Similarly, hydrodynamic changes appear to be responsible for reduced CBF in leukoaraiosis. The hydrodynamic properties of the periventricular veins make these vessels particularly vulnerable to ischemia and plaque formation. Venous hypertension in the dural sinuses can alter intracranial compliance. Consequently, venous hypertension may change the CSF dynamics, affecting the intracranial windkessel mechanism. MS and NPH appear to share some similar characteristics, with both conditions exhibiting increased CSF pulsatility in the aqueduct of Sylvius. CCSVI appears to be a real phenomenon associated with MS, which causes venous hypertension in the dural sinuses. However, the role of CCSVI in the pathophysiology of MS remains unclear. PMID:23724917

  13. Uncertainty Quantification for the Reliability of the Analytical Analysis for the Simplified Model of CO2 Geological Sequestration

    SciTech Connect

    Bao, Jie; Xu, Zhijie; Fang, Yilin

    2015-04-01

    A hydro-mechanical model with analytical solutions including pressure evolution and geomechanical deformation for geological CO2 injection and sequestration were introduced in our previous work. However, the reliability and accuracy of the hydro-mechanical model and the companion analytical solution are uncertain because of the assumptions and simplifications in the analytical model, though it was validated by a few example cases. This study introduce the method to efficiently measure the accuracy of the analytical model, and specify the acceptable input parameters range that can guarantee the accuracy and reliability of the analytical solution. A coupled hydro-geomechanical subsurface transport simulator STOMP was adopted as a reference to justify the reliability of the hydro-mechanical model and the analytical solution. A quasi-Monte Carlo sampling method was applied to efficiently sample the input parameter space.

  14. Proteomic analysis of synovial fluid as an analytical tool to detect candidate biomarkers for knee osteoarthritis.

    PubMed

    Liao, Weixiong; Li, Zhongli; Zhang, Hao; Li, Ji; Wang, Ketao; Yang, Yimeng

    2015-01-01

    We conducted research to detect the proteomic profiles in synovial fluid (SF) from knee osteoarthritis (OA) patients to better understand the pathogenesis and aetiology of OA. Our long-term goal is to identify reliable candidate biomarkers for OA in SF. The SF proteins obtained from 10 knee OA patients and 10 non-OA patients (9 of whom were patients with a meniscus injury in the knee; 1 had a discoid meniscus in the knee, and all exhibited intact articular cartilage) were separated by two-dimensional electrophoresis (2-DE). The repeatability of the obtained protein spots regarding their intensity was tested via triplicate 2-DE of selected samples. The observed protein expression patterns were subjected to statistical analysis, and differentially expressed protein spots were identified via matrix-assisted laser desorption/ionisation-time of flight/time of flight mass spectrometry (MALDI-TOF/TOF MS). Our analyses showed low intrasample variability and clear intersample variation. Among the protein spots observed on the gels, there were 29 significant differences, of which 22 corresponded to upregulation and 7 to downregulation in the OA group. One of the upregulated protein spots was confirmed to be haptoglobin by mass spectrometry, and the levels of haptoglobin in SF are positively correlated with the severity of OA (r = 0.89, P < 0.001). This study showed that 2-DE could be used under standard conditions to screen SF samples and identify a small subset of proteins in SF that are potential markers associated with OA. Spots of interest identified by mass spectrometry, such as haptoglobin, may be associated with OA severity.

  15. Disaster risk management in prospect mining area Blitar district, East Java, using microtremor analysis and ANP (analytical network processing) approach

    SciTech Connect

    Parwatiningtyas, Diyan E-mail: erlinunindra@gmail.com; Ambarsari, Erlin Windia E-mail: erlinunindra@gmail.com; Marlina, Dwi E-mail: erlinunindra@gmail.com; Wiratomo, Yogi E-mail: erlinunindra@gmail.com

    2014-03-24

    Indonesia has a wealth of natural assets is so large to be managed and utilized, either from its own local government and local communities, especially in the mining sector. However, mining activities can change the state of the surface layer of the earth that have a high impact disaster risk. This could threaten the safety and disrupt human life, environmental damage, loss of property, and the psychological impact, sulking to the rule of law no 24 of 2007. That's why we strive to manage and minimize the risk of mine disasters in the region, how to use the method of calculation of Amplification Factor (AF) from the analysis based microtremor sulking Kanai and Nakamura, and decision systems were tested by analysis of ANP. Based on the amplification factor and Analytical Network Processing (ANP) obtained, some points showed instability in the surface layer of a mining area include the site of the TP-7, TP-8, TP-9, TP-10, (Birowo2). If in terms of structure, location indicated unstable due to have a sloping surface layer, resulting in the occurrence of landslides and earthquake risk is high. In the meantime, other areas of the mine site can be said to be a stable area.

  16. Disaster risk management in prospect mining area Blitar district, East Java, using microtremor analysis and ANP (analytical network processing) approach

    NASA Astrophysics Data System (ADS)

    Parwatiningtyas, Diyan; Ambarsari, Erlin Windia; Marlina, Dwi; Wiratomo, Yogi

    2014-03-01

    Indonesia has a wealth of natural assets is so large to be managed and utilized, either from its own local government and local communities, especially in the mining sector. However, mining activities can change the state of the surface layer of the earth that have a high impact disaster risk. This could threaten the safety and disrupt human life, environmental damage, loss of property, and the psychological impact, sulking to the rule of law no 24 of 2007. That's why we strive to manage and minimize the risk of mine disasters in the region, how to use the method of calculation of Amplification Factor (AF) from the analysis based microtremor sulking Kanai and Nakamura, and decision systems were tested by analysis of ANP. Based on the amplification factor and Analytical Network Processing (ANP) obtained, some points showed instability in the surface layer of a mining area include the site of the TP-7, TP-8, TP-9, TP-10, (Birowo2). If in terms of structure, location indicated unstable due to have a sloping surface layer, resulting in the occurrence of landslides and earthquake risk is high. In the meantime, other areas of the mine site can be said to be a stable area.

  17. What workforce is needed to implement the health information technology agenda? Analysis from the HIMSS analytics database.

    PubMed

    Hersh, William; Wright, Adam

    2008-11-06

    One of the essential ingredients for health information technology implementation is a well trained and competent workforce. However, this workforce has not been quantified or otherwise characterized well. We extracted data from the HIMSS Analytics Database and extrapolated our findings to the US as a whole. We found that there are approximately 108,390 IT professionals in healthcare the US. In addition, the amount of IT staff hired varies by level of EMR adoption, with the rate of IT FTE per bed started at a level of 0.082 FTE per bed at the lowest level of the EMR Adoption Model (Stage0) and increasing to 0.210 FTE bed at higher levels(Stage 4). We can extrapolate nationally to conclude that to move the entire US to higher levels of adoption (Stage 4) will require an additional 40,784 IT professionals. There are limitations to this analysis, including that the data are limited to IT professionals who are mainly in hospitals and do not include those who, for example, work for vendors or in non-clinical settings. Furthermore, data on biomedical informatics professionals are still virtually non-existent. Our analysis adds to data that show there must be increasing attention paid to the workforce that will develop, implement, and evaluate HIT applications. Further research is essential to better characterize all types of workers needed for adoption of health information technology, including their job roles, required competencies, and optimal education.

  18. Meta-analysis of lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine.

    PubMed

    Zanton, G I; Bowman, G R; Vázquez-Añón, M; Rode, L M

    2014-11-01

    The objectives of our study were to evaluate the productive response to methionine supplementation in lactating dairy cows and to define a relationship between metabolizable Met (MP Met) intake and production. A database of 64 papers meeting the selection criteria was developed evaluating postruminally infused dl-methionine (9 papers with 18 control diets and 35 treatment comparisons), 2-hydroxy-4-methylthio butanoic acid (HMTBa) provided as either a liquid or Ca salt form (17 papers with 34 control diets and 46 treatment comparisons), Mepron (Evonik Industries, Essen, Germany; 18 papers with 35 control diets and 42 treatment comparisons), and Smartamine (Adisseo Inc., Antony, France; 20 papers with 30 control diets and 39 treatment comparisons). Dietary ingredients and their accompanying nutritional compositions as described in the reports were entered into the Cornell-Penn-Miner software to model the diets and to predict nutrients that were not reported in the original publication. Data were analyzed using a weighted analysis of response to supplementation compared with the intraexperiment control, as well as through a regression analysis to changing dietary MP Met. Data included in the analysis were from experiments published between 1970 and 2011 with cows supplemented with between 3.5 and 67.9 g of Met or its equivalent from HMTBa. Cows supplemented with Smartamine consumed more, whereas cows supplemented with Mepron consumed less DM compared with controls. Milk yield did not significantly respond to Met supplementation, although it tended to increase for cows supplemented with HMTBa and Mepron. Milk protein yield was increased due to supplementation from all sources or from infusion, and protein concentration was greater for all supplements or infusion of dl-Met, except for cows supplemented with HMTBa. Irrespective of Met source, milk protein yield increased 2.23 g of protein/g of MP Met until reaching the breakpoint. Milk fat yield was increased for Mepron

  19. Analytical Chemistry Laboratory

    NASA Technical Reports Server (NTRS)

    Anderson, Mark

    2013-01-01

    The Analytical Chemistry and Material Development Group maintains a capability in chemical analysis, materials R&D failure analysis and contamination control. The uniquely qualified staff and facility support the needs of flight projects, science instrument development and various technical tasks, as well as Cal Tech.

  20. Putting the "receive" in accounts receivable.

    PubMed

    McDaniel, John W; Baum, Neil

    2006-01-01

    There isn't a practice in the United States that doesn't have a concern about accounts receivable. The financial success of any practice depends on the care and feeding of the accounts receivable. This is not an area of practice management that can be taken lightly or delegated to someone who is not attentive to detail and doggedly persistent. In this article, we will discuss how to identify problematic accounts receivable and what can be done to bring the accounts receivable under control. We will provide you with a plan of action that can be adopted by any practice regardless of size, number of physicians, or whether the practice uses in-house billing or outsources its billing arrangements.