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Sample records for angra ii nuclear

  1. Front-end Design and Characterization for the ν-Angra Nuclear Reactor Monitoring Detector

    NASA Astrophysics Data System (ADS)

    Dornelas, T. I.; Araújo, F. T. H.; Cerqueira, A. S.; Costa, J. A.; Nóbrega, R. A.

    2016-07-01

    The Neutrinos Angra (ν-Angra) Experiment aims to construct an antineutrinos detection device capable of monitoring the Angra dos Reis nuclear reactor activity. Nuclear reactors are intense sources of antineutrinos, and the thermal power released in the fission process is directly related to the flow rate of these particles. The antineutrinos energy spectrum also provides valuable information on the nuclear source isotopic composition. The proposed detector will be equipped with photomultipliers tubes (PMT) which will be readout by a custom Amplifier-Shaper-Discriminator circuit designed to condition its output signals to the acquisition modules to be digitized and processed by an FPGA. The readout circuit should be sensitive to single photoelectron signals, process fast signals, with a full-width-half-amplitude of about 5 ns, have a narrow enough output pulse width to detect both particles coming out from the inverse beta decay (bar nue+p → n + e+), and its output amplitude should be linear to the number of photoelectrons generated inside the PMT, used for energy estimation. In this work, some of the main PMT characteristics are measured and a new readout circuit is proposed, described and characterized.

  2. The behavior of ANGRA 2 nuclear power plant core for a small break LOCA simulated with RELAP5 code

    SciTech Connect

    Sabundjian, Gaiane; Andrade, Delvonei A.; Belchior, Antonio Jr.; Silva Rocha, Marcelo da; Conti, Thadeu N.; Torres, Walmir M.; Macedo, Luiz A.; Umbehaun, Pedro E.; Mesquita, Roberto N.; Masotti, Paulo H. F.; Souza Lima, Ana Cecilia de

    2013-05-06

    This work discusses the behavior of Angra 2 nuclear power plant core, for a postulate Loss of Coolant Accident (LOCA) in the primary circuit for Small Break Loss Of Coolant Accident (SBLOCA). A pipe break of the hot leg Emergency Core Cooling System (ECCS) was simulated with RELAP 5 code. The considered rupture area is 380 cm{sup 2}, which represents 100% of the ECCS pipe flow area. Results showed that the cooling is enough to guarantee the integrity of the reactor core.

  3. The Angra Neutrino Project: precise measurement of {theta}{sub 13} and safeguards applications of neutrino detectors

    SciTech Connect

    Casimiro, E.; Anjos, J. C.

    2009-04-20

    We present an introduction to the Angra Neutrino Project. The goal of the project is to explore the use of neutrino detectors to monitor the reactor activity. The Angra Project, willl employ as neutrino sources the reactors of the nuclear power complex in Brazil, located in Angra dos Reis, some 150 Km south from the city of Rio de Janeiro. The Angra collaboration will develop and operate a low-mass neutrino detector to monitor the nuclear reactor activity, in particular to measure the reactor thermal power and the reactor fuel isotopic composition.

  4. Tritium ((3)H) as a tracer for monitoring the dispersion of conservative radionuclides discharged by the Angra dos Reis nuclear power plants in the Piraquara de Fora Bay, Brazil.

    PubMed

    de Carvalho Gomes, Franciane; Godoy, José Marcus; de Carvalho, Zenildo Lara; de Souza, Elder Magalhães; Rodrigues Silva, José Ivan; Tadeu Lopes, Ricardo

    2014-10-01

    Presently, two nuclear power plants operate in Brazil. Both are located at Itaorna beach, Angra dos Reis, approximately 133 km from Rio de Janeiro city. The reactor cooling circuits require the input of seawater, which is later discharged through a pipeline into the adjacent Piraquara de Fora Cove. The radioactive effluents undergo ion-exchange treatment prior to their release in batches, causing the enrichment of (3)H relative to other radionuclides in the discharged waters. Under steady state conditions, the (3)H gradient in the Piraquara de Fora waters can be used to determine the dependence of the dilution factor on the distance from the discharge point. The present work describes experiments carried out at the reactor site during batch release episodes, including time series sampling at the discharge point and surface seawater sampling every 250 m to a distance of 1250 m, after a double distillation, the (3)H concentration was measured by liquid scintillation counting applying a Quantulus liquid scintillation spectrometer. The obtained results showed a linear relationship between the (3)H concentration and distance from the discharge point. At 1250 m from the discharge point a dilution index of 1:15 was measured which fits the expected value based on modeling.

  5. Readout electronics validation and target detector assessment for the Neutrinos Angra experiment

    NASA Astrophysics Data System (ADS)

    Alvarenga, T. A.; Anjos, J. C.; Azzi, G.; Cerqueira, A. S.; Chimenti, P.; Costa, J. A.; Dornelas, T. I.; Farias, P. C. M. A.; Guedes, G. P.; Gonzalez, L. F. G.; Kemp, E.; Lima, H. P.; Machado, R.; Nóbrega, R. A.; Pepe, I. M.; Ribeiro, D. B. S.; Simas Filho, E. F.; Valdiviesso, G. A.; Wagner, S.

    2016-09-01

    A compact surface detector designed to identify the inverse beta decay interaction produced by anti-neutrinos coming from near operating nuclear reactors is being developed by the Neutrinos Angra Collaboration. In this document we describe and test the detector and its readout system by means of cosmic rays acquisition. In this measurement campaign, the target detector has been equipped with 16 8-in PMTs and two scintillator paddles have been used to trigger cosmic ray events. The achieved results disclosed the main operational characteristics of the Neutrinos Angra system and have been used to assess the detector and to validate its readout system.

  6. Nuclear pumped laser II

    NASA Technical Reports Server (NTRS)

    Deyoung, R. J.; Lee, J. H.; Pinkston, W. T.

    1977-01-01

    The first direct nuclear pumped laser using the He-2-(n,p) H-3 reaction is reported. Lasing took place on the 1.79 microns Ar I transition in a mixture of He-3-Ar at approximately 600 Torr total pressure. It was found that the electrically pulsed afterglow He-Ar laser had the same concentration profile as the nuclear pumped laser. As a result, nuclear lasing was also achieved in He-3-Xe (2.027 micron) and He-3-Kr (2.52 micron). Scaling of laser output with both thermal flux and total pressure as well as minority concentration has been completed. A peak output (He-3-Ar) of 3.7 watts has been achieved at a total pressure of 4 atm. Direct nuclear pumping of He-3-Ne has also been achieved. Nuclear pumping of a He-3-NF3 mixture was attempted, lasing in FI at approximately 7000 A, without success, although the potential lasing transitions appeared in spontaneous emission. Both NF3 and 238UF6 appear to quench spontaneous emission when they constitute more than 1% of the gas mixture.

  7. Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.

    PubMed

    Serebryannyy, Leonid A; Parilla, Megan; Annibale, Paolo; Cruz, Christina M; Laster, Kyle; Gratton, Enrico; Kudryashov, Dmitri; Kosak, Steven T; Gottardi, Cara J; de Lanerolle, Primal

    2016-09-15

    Actin is abundant in the nucleus and it is clear that nuclear actin has important functions. However, mystery surrounds the absence of classical actin filaments in the nucleus. To address this question, we investigated how polymerizing nuclear actin into persistent nuclear actin filaments affected transcription by RNA polymerase II. Nuclear filaments impaired nuclear actin dynamics by polymerizing and sequestering nuclear actin. Polymerizing actin into stable nuclear filaments disrupted the interaction of actin with RNA polymerase II and correlated with impaired RNA polymerase II localization, dynamics, gene recruitment, and reduced global transcription and cell proliferation. Polymerizing and crosslinking nuclear actin in vitro similarly disrupted the actin-RNA-polymerase-II interaction and inhibited transcription. These data rationalize the general absence of stable actin filaments in mammalian somatic nuclei. They also suggest a dynamic pool of nuclear actin is required for the proper localization and activity of RNA polymerase II.

  8. Nuclear instrumentation system operating experience and nuclear instrument testing in the EBR-II

    SciTech Connect

    Yingling, G. E.; Curran, R. N.

    1980-01-01

    In March of 1972 three wide range nuclear channels were purchased from Gulf Atomics Corporation and installed in EBR-II as a test. The three channels were operated as a test until April 1975 when they became a permanent part of the reactor shutdown system. Also described are the activities involved in evaluating and qualifying neutron detectors for LMFBR applications. Included are descriptions of the ANL Components Technology Division Test Program and the EBR-II Nuclear Instrument Test Facilities (NITF) used for the in-reactor testing and a summary of program test results from EBR-II.

  9. Open Questions in Stellar Nuclear Physics: II

    SciTech Connect

    Gai, Moshe

    2004-09-13

    No doubt, among the most exciting discoveries of the third millennium thus far are oscillations of massive neutrinos and dark energy that leads to an accelerated expansion of the Universe. Accordingly, Nuclear Physics is presented with two extraordinary challenges: the need for precise (5% or better) prediction of solar neutrino fluxes within the Standard Solar Model, and the need for an accurate (5% or better) understanding of stellar evolution and in particular of Type Ia super nova that are used as cosmological standard candle. In contrast, much confusion is found in the field with contradicting data and strong statements of accuracy that can not be supported by current data. We discuss an experimental program to address these challenges and disagreements.

  10. Deployment of the Topaz-II space nuclear power plant

    SciTech Connect

    Standley, V.H.; Wyant, F.J.; Polansky, G.F. )

    1993-01-01

    The Topaz-II is a 5-kW(electric) Russian space nuclear power plant. The power plant resembles a shuttlecock standing 3.9 m high and is 1.4 m in diameter at the base. The reactor is at the top, the radiation shield is in the middle, and the radiator is at the bottom. The whole system weighs 1 tonne. The reactor core is 37.5 cm long and 26 cm in diameter. It contains 37 core-length, single-cell thermionic fuel elements embedded in a ZrH moderator. Each thermionic fuel cell is a cylindrical emitter inside a cylindrical collector. Nuclear fuel inside the emitter raises the emitter's temperature.

  11. Trace Element Distribution Between Olivine and Kirschsteinite in Angra Dos Reis

    NASA Technical Reports Server (NTRS)

    Fittipaldo, M. M.; Jones, R. H.; Shearer, C. K.

    2003-01-01

    The angrites are a small and enigmatic group of basaltic achondrites that possess unique mineralogical and chemical properties. The dominant mineralogy of the seven angrite members (Angra dos Reis, LEW 86010, LEW 87051, Asuka 881371, Sahara 99555, D Orbigny, and a new Moroccan member) is fassaite, olivine, and plagioclase. Angrites display a wide range of thermal histories, with Angra dos Reis (AdoR) exhibiting a cooling history different from that of the rapidly cooled members and from LEW86010, a more slowly cooled member. AdoR could represent either a cumulate or a porphyritic igneous rock that was later altered by metamorphism. We are re-examining the thermal history of AdoR in light of the more recently described angrite members. Our emphasis is a trace element study of low-Ca olivine, which we refer to as olivine, and high-Ca olivine, which we refer to as kirschsteinite, in AdoR.

  12. 10 CFR 76.115 - Special nuclear material of moderate strategic significance-Category II.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Special nuclear material of moderate strategic significance-Category II. 76.115 Section 76.115 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safeguards and Security § 76.115 Special nuclear material of...

  13. 10 CFR 76.115 - Special nuclear material of moderate strategic significance-Category II.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Special nuclear material of moderate strategic significance-Category II. 76.115 Section 76.115 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safeguards and Security § 76.115 Special nuclear material of...

  14. 10 CFR 76.115 - Special nuclear material of moderate strategic significance-Category II.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Special nuclear material of moderate strategic significance-Category II. 76.115 Section 76.115 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safeguards and Security § 76.115 Special nuclear material of...

  15. 10 CFR 76.115 - Special nuclear material of moderate strategic significance-Category II.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Special nuclear material of moderate strategic significance-Category II. 76.115 Section 76.115 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safeguards and Security § 76.115 Special nuclear material of...

  16. 10 CFR 76.115 - Special nuclear material of moderate strategic significance-Category II.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Special nuclear material of moderate strategic significance-Category II. 76.115 Section 76.115 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS Safeguards and Security § 76.115 Special nuclear material of...

  17. Nuclear Technology Series. Course 32: Nondestructive Examination (NDE) Techniques II.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  18. Nuclear Technology Series. Course 17: Radiation Protection II.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  19. Nuclear Technology Series. Course 34: Control Systems II.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  20. Age and isotopic relationships among the angrites Lewis Cliff 86010 and Angra dos Reis

    SciTech Connect

    Lugmair, G.W. ); Galer, S.J.G. Max-Planck-Inst. fuer Chemie, Mainz )

    1992-04-01

    Results of a wide-ranging isotopic investigation of the unique Antarctican angrite LEW-86010 (LEW) are presented, together with a reassessment of the type angrite Angra dos Reis (ADOR). The principal objectives of this study are to obtain precise radiometric ages, initial Sr isotopic compositions, and to search for the erstwhile presence of the short-lived nuclei {sup 146}Sm and {sup 26}Al via their daughter products. The isotopic compositions of Sm, U, Ca, and Ti were also measured. This allows a detailed appraisal to be made of the relations between, and the genealogy of, these two angrites.

  1. Studies of Brazilian meteorites. III - Origin and history of the Angra dos Reis achondrite

    NASA Technical Reports Server (NTRS)

    Prinz, M.; Keil, K.; Hlava, P. F.; Berkley, J. L.; Gomes, C. B.; Curvello, W. S.

    1977-01-01

    The mineral composition of the Angra dos Reis meteorite, which fell in 1869, is described. This achondrite contains phases reported in a meteorite for the first time. Petrofabric analysis shows that fassaite has a preferred orientation and lineation, which is interpreted as being due to cumulus processes, possibly the effect of post-depositional magmatic current flow or laminar flow of a crystalline mush. The mineral chemistry indicates crystallization from a highly silica-undersaturated melt at low pressure. Several aspects of the mineral composition are discussed with reference to the implications of crystallization conditions.

  2. Pokhran II and Beyond (Emerging Indian Nuclear Posture)

    DTIC Science & Technology

    2002-04-01

    14 1945 to Pokhran-I India’s independent research in the field of nuclear physics started as early as 1945. Homi J Bhabha , an Indian physicist...of nuclear physics.’15 After independence, the first Indian Prime Minister, Jawahar Lal Nehru, was in turn duly convinced by Bhabha to continue...the wanton destructiveness of nuclear weapons’17 but on the other he granted Bhabha ‘a free hand in the development of India’s nuclear

  3. Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2.

    PubMed

    Forget, Diane; Lacombe, Andrée-Anne; Cloutier, Philippe; Lavallée-Adam, Mathieu; Blanchette, Mathieu; Coulombe, Benoit

    2013-08-01

    The RNA polymerase II (RNAP II)-associated protein (RPAP) 2 has been discovered through its association with various subunits of RNAP II in affinity purification coupled with mass spectrometry experiments. Here, we show that RPAP2 is a mainly cytoplasmic protein that shuttles between the cytoplasm and the nucleus. RPAP2 shuttling is tightly coupled with nuclear import of RNAP II, as RPAP2 silencing provokes abnormal accumulation of RNAP II in the cytoplasmic space. Most notably, RPAP4/GPN1 silencing provokes the retention of RPAP2 in the nucleus. Our results support a model in which RPAP2 enters the nucleus in association with RNAP II and returns to the cytoplasm in association with the GTPase GPN1/RPAP4. Although binding of RNAP II to RPAP2 is mediated by an N-terminal domain (amino acids 1-170) that contains a nuclear retention domain, and binding of RPAP4/GPN1 to RPAP2 occurs through a C-terminal domain (amino acids 156-612) that has a dominant cytoplasmic localization domain. In conjunction with previously published data, our results have important implications, as they indicate that RPAP2 controls gene expression by two distinct mechanisms, one that targets RNAP II activity during transcription and the other that controls availability of RNAP II in the nucleus.

  4. Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart

    PubMed Central

    Doan, ND; Nguyen, TTM; Létourneau, M; Turcotte, K; Fournier, A; Chatenet, D

    2012-01-01

    BACKGROUND AND PURPOSE During the past decade, a few GPCRs have been characterized at the nuclear membrane where they exert complementary physiological functions. In this study, we investigated (1) the presence of a functional urotensin-II (U-II) receptor (UT) in rat heart nuclear extracts and (2) the propensity of U-II and U-II-related peptide (URP) to cross the plasma membrane in a receptor-independent manner. EXPERIMENTAL APPROACH Biochemical and pharmacological methods including competitive binding assays, photoaffinity labelling, immunoblotting as well as de novo RNA synthesis were used to characterize the presence of functional UT receptors in rat heart nuclei. In addition, confocal microscopy and flow cytometry analysis were used to investigate the cellular uptake of fluorescent U-II and URP derivatives. KEY RESULTS The presence of specific U-II binding sites was demonstrated in rat heart nuclear extracts. Moreover, such subcellular localization was also observed in monkey heart extracts. In vitro transcription initiation assays on rat, freshly isolated, heart nuclei suggested that nuclear UT receptors are functional, and that U-II, but not URP, participates in nuclear UT-associated gene expression. Surprisingly, hU-II and URP efficiently crossed the plasma membrane in a receptor-independent mechanism involving endocytosis through caveolin-coated pits; this uptake of hU-II, but not that of URP, was dependent on extracellular pH. CONCLUSION Our results suggest that (1) U-II and URP can differentially modulate nuclear UT functions such as gene expression, and (2) both ligands can reach the internal cellular space through a receptor-independent mechanism. PMID:22044114

  5. Proton nuclear magnetic resonance and spectrophotometric studies of nickel(II)-iron(II) hybrid hemoglobins

    SciTech Connect

    Shibayama, N.; Inubushi, T.; Morimoto, H.; Yonetani, T.

    1987-04-21

    Ni(II)-Fe(II) hybrid hemoglobins, ..cap alpha..(Fe)/sub 2/..beta..(Ni)/sub 2/ and ..cap alpha..(Ni)/sub 2/..beta..(Fe)/sub 2/, have been characterized by proton nuclear magnetic resonance with Ni(II) protoporphyrin IX (Ni-PP) incorporated in apoprotein, which serves as a permanent deoxyheme. ..cap alpha..(Fe)/sub 2/..beta..(Ni)/sub 2/, ..cap alpha..(Ni)/sub 2/..beta..(Fe)/sub 2/, and NiHb commonly show exchangeable proton resonances at 11 and 14 ppm, due to hydrogen-bonded protons in a deoxy-like structure. Upon binding of carbon monoxide (CO) to ..cap alpha..(Fe)/sub 2/..beta..(Ni)/sub 2/, these resonances disappear at pH 6.5 to pH 8.5. On the other hand, the complementary hybrid ..cap alpha..(Ni)/sub 2/..beta..(Fe-CO)/sub 2/ showed the 11 and 14 ppm resonances at low pH. Upon raising pH, the intensities of both resonances are reduced, although these changes are not synchronized. Electronic absorption spectra and hyperfine-shifted proton resonances indicate that the ligation of CO in the ..beta..(Fe) subunits induced changes in the coordination and spin states of Ni-PP in the ..cap alpha.. subunits. In a deoxy-like structure, the coordination of Ni-PP in the ..cap alpha.. subunits is predominantly in a low-spin (S = 0) four-coordination state, whereas in an oxy-like structure the contribution of a high-spin (S = 1) five-coordination state markedly increased. Ni-PP in the ..beta.. subunits always takes a high-spin five-coordination state regardless of solution conditions and the state of ligation in the partner ..cap alpha..(Fe) subunits. In the ..beta..(Ni) subunits, a significant downfield shift of the proximal histidyl N/sub delta/H resonance and a change in the absorption spectrum of Ni-PP were detected, upon changing the quaternary structure of the hybrid. The chemical shifts were analyzed in terms of the E11-Val methyls vs. the porphyrin rings in hybrid Hbs.

  6. Age and isotopic relationships among the angrites Lewis Cliff 86010 and Angra dos Reis

    NASA Technical Reports Server (NTRS)

    Lugmair, G. W.; Galer, S. J. G.

    1992-01-01

    The paper presents results of a wide-ranging isotopic investigation of the the Antarctic angrite LEW-86010 (LEW), and reassesses the type angrite Angra dos Reis (ADOR) in order to obtain precise radiometric ages and initial Sr isotopic compositions, and to search for the erstwhile presence of the short-lived nuclei Sm-146 and Al-26 via their daughter products. The isotopic compositions of Sm, U, Ca, and Ti were measured to allow a detailed appraisal to be made of the relations between, and the geneology of, these two angrites. LEW proves to be severely contaminated with modern terrestrial Pb, which is shown to result from terrestrial weathering. Concordant Pb-Pb model ages of pyroxene separates are obtained; uranium isotopic compositions are normal within error. Overall, striking age and isotopic similarities between LEW and ADOR were found, suggesting almost simultaneous production on the same asteroid, even though recent experimental studies imply that the two are not comagmatic.

  7. Measured oxygen fugacities of the Angra dos Reis achondrite as a function of temperature

    USGS Publications Warehouse

    Brett, R.; Stephen, Huebner J.; Sato, M.

    1977-01-01

    Measurements of the oxygen fugacity (f{hook}O2) as a function of temperature (T) were made on an interior bulk sample of the cumulate achondrite, Angra dos Reis. Data clustered between the f{hook}O2-T relationship of the iron-wu??stite assemblage and 1.2 log atm units above iron-wu??stite. Interpretation of the data indicates that, throughout most of the cooling history of the meteorite, f{hook}O2 values were defined by equilibria involving iron-bearing species at values close to the f{hook}O2 of the assemblage iron-wu??stite. Measured f{hook}O2 data are compatible with crystallization and cooling at pressures greater than 50 bars. ?? 1977.

  8. Different pathways for the nuclear import of yeast RNA polymerase II.

    PubMed

    Gómez-Navarro, Natalia; Estruch, Francisco

    2015-11-01

    Recent studies suggest that RNA polymerase II (Pol II) has to be fully assembled before being imported into the nucleus, while other reports indicate a distinct mechanism to import large and small subunits. In yeast, Iwr1 binds to the holoenzyme assembled in the cytoplasm and directs its nuclear entry. However, as IWR1 is not an essential gene, Iwr1-independent pathway(s) for the nuclear import of Pol II must exist. In this paper, we investigate the transport into the nucleus of several large and small Pol II subunits in the mutants of genes involved in Pol II biogenesis. We also analyse subcellular localization in the presence of drugs that can potentially affect Pol II nuclear import. Our results show differences in the cellular distribution between large and small subunits when Pol II biogenesis was impaired. Our data suggest that, in addition to the fully assembled holoenzyme, Pol II subunits can be imported to the nucleus, either independently or as partial assemblies, through different pathways, including passive diffusion for the small subunits.

  9. Commercial Nuclear Steam-Electric Power Plants, Part II

    ERIC Educational Resources Information Center

    Shore, Ferdinand J.

    1974-01-01

    Presents the pros and cons of nuclear power systems. Includes a discussion of the institutional status of the AEC, AEC regulatory record, routine low-level radiation hazards, transport of radioactive materials, storage of wastes, and uranium resources and economics of supply. (GS)

  10. Startup control of the TOPAZ-II space nuclear reactor. Master`s thesis

    SciTech Connect

    Astrin, C.D.

    1996-09-01

    The Russian designed and manufactured TOPAZ-II Thermionic Nuclear Space Reactor has been supplied to the Ballistic Missile Defense Organization for study as part of the TOPAZ International Program. A Preliminary Nuclear Safety Assessment investigated the readiness to use the TOPAZ-II in support of a Nuclear Electric Propulsion Space Test Mission (NEPSTP). Among the anticipated system modifications required for launching the TOPAZ-II system within safety goals is for a U.S. designed Automatic Control System. The requirements and desired features of such a control system are developed based upon U.S. safety standards. System theory and design are presented in order to establish the basis for development of a hybrid control model from available simulations. The model is verified and then used in exploration of various control schemes and casualty analysis providing groundwork for future Automatic Control System design.

  11. Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module

    PubMed Central

    Wiggan, O’Neil; Schroder, Bryce; Krapf, Diego; Bamburg, James R.; DeLuca, Jennifer G.

    2017-01-01

    Structural features of the nucleus including shape, size and deformability impact its function affecting normal cellular processes such as cell differentiation and pathological conditions such as tumor cell migration. Despite the fact that abnormal nuclear morphology has long been a defining characteristic for diseases such as cancer relatively little is known about the mechanisms that control normal nuclear architecture. Mounting evidence suggests close coupling between F-actin cytoskeletal organization and nuclear morphology however, mechanisms regulating this coupling are lacking. Here we identify that Cofilin/ADF-family F-actin remodeling proteins are essential for normal nuclear structure in different cell types. siRNA mediated silencing of Cofilin/ADF provokes striking nuclear defects including aberrant shapes, nuclear lamina disruption and reductions to peripheral heterochromatin. We provide evidence that these anomalies are primarily due to Rho kinase (ROCK) controlled excessive contractile myosin-II activity and not to elevated F-actin polymerization. Furthermore, we demonstrate a requirement for nuclear envelope LINC (linker of nucleoskeleton and cytoskeleton) complex proteins together with lamin A/C for nuclear aberrations induced by Cofilin/ADF loss. Our study elucidates a pivotal regulatory mechanism responsible for normal nuclear structure and which is expected to fundamentally influence nuclear function. PMID:28102353

  12. Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module.

    PubMed

    Wiggan, O'Neil; Schroder, Bryce; Krapf, Diego; Bamburg, James R; DeLuca, Jennifer G

    2017-01-19

    Structural features of the nucleus including shape, size and deformability impact its function affecting normal cellular processes such as cell differentiation and pathological conditions such as tumor cell migration. Despite the fact that abnormal nuclear morphology has long been a defining characteristic for diseases such as cancer relatively little is known about the mechanisms that control normal nuclear architecture. Mounting evidence suggests close coupling between F-actin cytoskeletal organization and nuclear morphology however, mechanisms regulating this coupling are lacking. Here we identify that Cofilin/ADF-family F-actin remodeling proteins are essential for normal nuclear structure in different cell types. siRNA mediated silencing of Cofilin/ADF provokes striking nuclear defects including aberrant shapes, nuclear lamina disruption and reductions to peripheral heterochromatin. We provide evidence that these anomalies are primarily due to Rho kinase (ROCK) controlled excessive contractile myosin-II activity and not to elevated F-actin polymerization. Furthermore, we demonstrate a requirement for nuclear envelope LINC (linker of nucleoskeleton and cytoskeleton) complex proteins together with lamin A/C for nuclear aberrations induced by Cofilin/ADF loss. Our study elucidates a pivotal regulatory mechanism responsible for normal nuclear structure and which is expected to fundamentally influence nuclear function.

  13. Proceedings of the 1984 DOE nuclear reactor and facility safety conference. Volume II

    SciTech Connect

    Not Available

    1984-01-01

    This report is a collection of papers on reactor safety. The report takes the form of proceedings from the 1984 DOE Nuclear Reactor and Facility Safety Conference, Volume II of two. These proceedings cover Safety, Accidents, Training, Task/Job Analysis, Robotics and the Engineering Aspects of Man/Safety interfaces.

  14. Multiparticle Production in Particle and Nuclear Collisions. II

    NASA Astrophysics Data System (ADS)

    Kanki, T.; Kinoshita, K.; Sumiyoshi, H.; Takagi, F.

    The dominant phenomenon in high-energy particle and nuclear collisions is multiple production of hadrons. This had attracted may physicists in 1950's, the period of the first remarkable development of particle physics. Multiparticle production was already observed in cosmic-ray experiments and expected to be explained as a natural consequence of the strong Yukawa interaction. Statistical and hydrodynamical models were then proposed by Fermi, Landau and others. These theories are still surviving even today as a prototype of modern ``fire-ball'' models. After twenty years, a golden age came in this field of physics. It was closely related to the rapid development of accelerator facilities, especially, the invention of colliding-beam machines which yield high enough center-of-mass energies for studying reactions with high multiplicity. Abundant data on final states of multiparticle production have been accumulated mainly by measuring inclusive cross sections and multiplicity distributions. In super high-energy bar{p}p collisions at CERN S pmacr pS Collider, we confirmed the increasing total cross section and found violations of many scaling laws which seemed to be valid at lower energies. This suggests a fundamental complexity of the multiparticle phenomena and offers new materials for further development of theoretical investigations. In the same period, studies of constituent (quark-gluon) structure of hadrons had also been develped. Nowadays, pysicists believe that the quantum chromodynamics (QCD) is the fundamental law of the hadronic world. Multiparticle dynamics should also be described by QCD. We have known that the hard-jet phenomena are well explained by the perturbative QCD. On the other hand, the soft processes are considered to be non-perturbative phenomena which have not yet been solved, and related to the mechanism of the color confinement and formation of strings or color-flux tubes. Multiparticle production would offer useful information on this

  15. Optical spectrophotometry of the nuclear region of M51. II - Further evidence for nuclear activity

    NASA Astrophysics Data System (ADS)

    Rose, J. A.; Cecil, G.

    1983-03-01

    Spectrophotometric observations of the spiral galaxy M51 conducted by Rose and Searle (1982) have revealed that the ionized gas within the central region exhibits a peculiar emission-line spectrum and is undergoing large chaotic motions. These phenomena appear to result from low-level nuclear activity qualitatively similar to that seen in Seyfert galaxy nuclei and QSOs. It has been proposed that the gas is photoionized by a central nonstellar ultraviolet continuum. The present study is concerned with a further investigation of the ionization source in the nuclear region of M51, taking into account high signal-to-noise spectra obtained with an intensified Reticon detector on the 2.24 m telescope at the Mauna Kea Observatory. It is found that photoionization by a central nonstellar ionizing continuum source provides the most consistent explanation for the observed anomalous emission-line spectrum.

  16. Independent Safety Assessment of the TOPAZ-II space nuclear reactor power system (Revised)

    SciTech Connect

    1993-09-01

    The Independent Safety Assessment described in this study report was performed to assess the safety of the design and launch plans anticipated by the U.S. Department of Defense (DOD) in 1993 for a Russian-built, U.S.-modified, TOPAZ-II space nuclear reactor power system. Its conclusions, and the bases for them, were intended to provide guidance for the U.S. Department of Energy (DOE) management in the event that the DOD requested authorization under section 91b. of the Atomic Energy Act of 1954, as amended, for possession and use (including ground testing and launch) of a nuclear-fueled, modified TOPAZ-II. The scientists and engineers who were engaged to perform this assessment are nationally-known nuclear safety experts in various disciplines. They met with participants in the TOPAZ-II program during the spring and summer of 1993 and produced a report based on their analysis of the proposed TOPAZ-II mission. Their conclusions were confined to the potential impact on public safety and did not include budgetary, reliability, or risk-benefit analyses.

  17. Rare earth elements in Angra dos Reis and Lewis Cliff 86010, two meteorites with similar but distinct magma evolutions

    NASA Technical Reports Server (NTRS)

    Crozaz, Ghislaine; Mckay, Gordon

    1990-01-01

    Data are presented on ion microprobe measurements of REE and selected trace element abundances in individual grains of merrillite, fassaite, olivine, kirschsteinite, and plagioclase of Lewis Cliff 86010 (LEW 86010) meteorite and in merrillite and fassaite grains of Angra dos Reis (ADOR). Results show a close relationship between the two meteorites and support a magmatic origin for LEW 86010. However, the measurements indicate that, despite numerous common characteristics, the two meteorites must have been produced in separate magmatic events involving similar but distinct processes and parent melts.

  18. Physics with gamma-beams and charged particle detectors: I) Nuclear structure II) Nuclear astrophysics

    NASA Astrophysics Data System (ADS)

    Gai, Moshe

    2015-02-01

    The Charged Particle Working Group (CPWG) is proposing to construct large area Silicon Strip Detector (SSD), a gas Time Projection Chamber detector read by an electronic readout system (eTPC) and a Bubble Chamber (BC) containing superheated high purity water to be used in measurements utilizing intense gamma-ray beams from the newly constructed ELI-NP facility at Magurele, Bucharest in Romania. We intend to use the SSD and eTPC detectors to address essential problems in nuclear structure physics, such as clustering and the many alpha-decay of light nuclei such as 12C and 16O . All three detectors (SSD, eTPC and BC) will be used to address central problems in nuclear astrophysics such as the astrophysical cross section factor of the 12C (α,γ) reaction and other processes central to stellar evolution. The CPWG intends to submit to the ELI-NP facility a Technical Design Report (TDR) for the proposed detectors.

  19. Physics with gamma-beams and charged particle detectors: I) Nuclear structure II) Nuclear astrophysics

    SciTech Connect

    Gai, Moshe

    2015-02-24

    The Charged Particle Working Group (CPWG) is proposing to construct large area Silicon Strip Detector (SSD), a gas Time Projection Chamber detector read by an electronic readout system (eTPC) and a Bubble Chamber (BC) containing superheated high purity water to be used in measurements utilizing intense gamma-ray beams from the newly constructed ELI-NP facility at Magurele, Bucharest in Romania. We intend to use the SSD and eTPC detectors to address essential problems in nuclear structure physics, such as clustering and the many alpha-decay of light nuclei such as {sup 12}C and {sup 16}O. All three detectors (SSD, eTPC and BC) will be used to address central problems in nuclear astrophysics such as the astrophysical cross section factor of the {sup 12}C(α,γ) reaction and other processes central to stellar evolution. The CPWG intends to submit to the ELI-NP facility a Technical Design Report (TDR) for the proposed detectors.

  20. Sliding mode control of the space nuclear reactor system TOPAZ II

    SciTech Connect

    Shtessel, Y.B.; Wyant, F.J.

    1996-03-01

    The Automatic Control System (ACS) of the space nuclear reactor power system TOPAZ II that generates electricity from nuclear heat using in-core thermionic converters is considered. Sliding Mode Control Technique was applied to the reactor system controller design in order to provide the robust high accuracy following of a neutron (thermal) power reference profile in a start up regime and a payload electric power (current) reference profile following in an operation regime. Extensive simulations of the TOPAZ II reactor system with the designed sliding mode controllers showed improved accuracy and robustness of the reactor system performances in a start up regime and in an electric power supply regime as well. {copyright} {ital 1996 American Institute of Physics.}

  1. Nuclear Shell Structure and Beta Decay I. Odd A Nuclei II. Even A Nuclei

    DOE R&D Accomplishments Database

    Mayer, M.G.; Moszkowski, S.A.; Nordheim, L.W.

    1951-05-01

    In Part I a systematics is given of all transitions for odd A nuclei for which sufficiently reliable data are available. The allowed or forbidden characters of the transitions are correlated with the positions of the initial and final odd nucleon groups in the nuclear shell scheme. The nuclear shells show definite characteristics with respect to parity of the ground states. The latter is the same as the one obtained from known spins and magnetic moments in a one-particle interpretation. In Part II a systematics of the beta transitions of even-A nuclei is given. An interpretation of the character of the transitions in terms of nuclear shell structure is achieved on the hypothesis that the odd nucleon groups have the same structure as in odd-A nuclei, together with a simple coupling rule between the neutron and proton groups in odd-odd nuclei.

  2. Nuclear Infrared Spectral Energy Distribution of Type II Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Videla, Liza; Lira, Paulina; Andrews, Heather; Alonso-Herrero, Almudena; Alexander, David M.; Ward, Martin

    2013-02-01

    We present near- and mid-IR observations of a sample of Seyfert II galaxies drawn from the 12 μm Galaxy sample. The sample was observed in the J, H, K, L, M and N bands. Galaxy surface brightness profiles are modeled using nuclear, bulge, bar (when necessary), and disk components. To check the reliability of our findings, the procedure was tested using Spitzer observations of M 31. Nuclear spectral energy distributions (SEDs) are determined for 34 objects, and optical spectra are presented for 38, including analysis of their stellar populations using the STARLIGHT spectral synthesis code. Emission line diagnostic diagrams are used to discriminate between genuine active galactic nuclei (AGNs) and H II nuclei. Combining our observations with those found in the literature, we have a total of 40 SEDs. It is found that about 40% of the SEDs are characterized by an upturn in the near-IR, which we have quantified as a NIR slope α < 1 for an SED characterized as λf λvpropλα. The three objects with an H II nucleus and two Seyfert nuclei with strong contamination from a circumnuclear also show an upturn. For genuine AGNs, this component could be explained as emission from the accretion disk, a jet, or from a very hot dust component leaking from the central region through a clumpy obscuring structure. The presence of a very compact nuclear starburst as the origin for this NIR excess emission is not favored by our spectroscopic data for these objects.

  3. Preliminary nuclear safety assessment of the NEPST (Topaz II) space reactor program

    SciTech Connect

    Marshall, A.C.

    1993-01-01

    The United States (US) Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary nuclear safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary nuclear safety assessment included a number of deterministic analyses, such as; neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, an analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment to date, it appears that it will be possible to safely launch the Topaz II system in the US with a modification to preclude water flooded criticality. A full scale safety program is now underway.

  4. Nuclear structure and the fate of core collapse (Type II) supernova

    NASA Astrophysics Data System (ADS)

    Gai, Moshe

    2014-08-01

    For a long time Gerry Brown and his collaborator Hans Bethe considered the question of the final fate of a core collapse (Type II) supernova. Recalling ideas from nuclear structure on Kaon condensate and a soft equation of state of the dense nuclear matter they concluded that progenitor stars with mass as low as 17-18M⊙ (including supernova 1987A) could collapse to a small mass black hole with a mass just beyond 1.5M⊙, the upper bound they derive for a neutron star. We discuss another nuclear structure effect that determines the carbon to oxygen ratio (C/O) at the end of helium burning. This ratio also determines the fate of a Type II supernova with a carbon rich progenitor star producing a neutron star and oxygen rich collapsing to a black hole. While the C/O ratio is one of the most important nuclear inputs to stellar evolution it is still not known with sufficient accuracy. We discuss future efforts to measure with gamma-beam and TPC detector of the C12(α,γ)O16 reaction that determines the C/O ratio in stellar helium burning.

  5. Angiotensin II activates the proinflammatory transcription factor nuclear factor-kappaB in human monocytes.

    PubMed

    Kranzhöfer, R; Browatzki, M; Schmidt, J; Kübler, W

    1999-04-21

    The renin-angiotensin system may contribute to the pathogenesis of atherosclerosis. A common feature of all stages of atherosclerosis is inflammation of the vessel wall. The transcription factor nuclear factor-kappaB (NF-kappaB) participates in most signaling pathways involved in inflammation. This study therefore examined the effect of angiotensin (ANG) II on NF-kappaB activation in monocytic cells, a major cellular component of human atheroma, by electrophoretic mobility shift assay. ANG II, like TNFalpha, caused rapid activation of NF-kappaB in human mononuclear cells isolated from peripheral blood by Ficoll density gradient. This ANG II effect was blocked by the angiotensin AT1 receptor antagonist losartan. Specificity of ANG II-induced NF-kappaB activation was ascertained by supershift and competition experiments. Moreover, ANG II stimulated NF-kappaB activation in human monocytes, but not in lymphocytes from the same preparation. Together, the data demonstrate the ability of the vasoactive peptide ANG II to activate inflammatory pathways in human monocytes.

  6. RNA-RNA interactions and pre-mRNA mislocalization as drivers of group II intron loss from nuclear genomes.

    PubMed

    Qu, Guosheng; Dong, Xiaolong; Piazza, Carol Lyn; Chalamcharla, Venkata R; Lutz, Sheila; Curcio, M Joan; Belfort, Marlene

    2014-05-06

    Group II introns are commonly believed to be the progenitors of spliceosomal introns, but they are notably absent from nuclear genomes. Barriers to group II intron function in nuclear genomes therefore beg examination. A previous study showed that nuclear expression of a group II intron in yeast results in nonsense-mediated decay and translational repression of mRNA, and that these roadblocks to expression are group II intron-specific. To determine the molecular basis for repression of gene expression, we investigated cellular dynamics of processed group II intron RNAs, from transcription to cellular localization. Our data show pre-mRNA mislocalization to the cytoplasm, where the RNAs are targeted to foci. Furthermore, tenacious mRNA-pre-mRNA interactions, based on intron-exon binding sequences, result in reduced abundance of spliced mRNAs. Nuclear retention of pre-mRNA prevents this interaction and relieves these expression blocks. In addition to providing a mechanistic rationale for group II intron-specific repression, our data support the hypothesis that RNA silencing of the host gene contributed to expulsion of group II introns from nuclear genomes and drove the evolution of spliceosomal introns.

  7. Random vibration analysis of the Topaz-II nuclear reactor power system. Master`s thesis

    SciTech Connect

    Campbell, S.E.

    1995-06-01

    The TOPAZ-II Ya-21U is one of six Russian made space nuclear power systems which is based on theomionic power conversion. The U.S. is presently analyzing TOPAZ-II to determine the reliability and feasibility of using this system. A structural analysis test was conducted on the TOPAZ unit in May 1993 to provide data from which modal parameters could be identified. This test showed the fundamental frequency to be 10.5 Hz, yet the test results that the Russians conducted identified a fundamental frequency of 5 Hz. Another finite element model was created incorporating new developments in TOPAZ-II and modifications to the finite element model to better simulate the mass properties of the TOPAZ-II2. A second structural analysis test was conducted on the TOPAZ unit 06-09 September 1994. This thesis focuses on the random vibration analysis of the TOPAZ-II Ya-2lU utilizing the most recent test results and the Master Series (updated version) I-DEAS software. The modal respose of the model and simulated random vibration tests were within 8.33%. This model is a feasible tool which can be used to analyze the TOPAZ unit without testing the unit to fatigue.

  8. American Physicists, Nuclear Weapons in World War II, and Social Responsibility

    NASA Astrophysics Data System (ADS)

    Badash, Lawrence

    2005-06-01

    Social responsibility in science has a centuries-long history, but it was such a minor thread that most scientists were unaware of the concept. Even toward the conclusion of the Manhattan Project, which produced the first nuclear weapons, only a handful of its participants had some reservations about use of a weapon of mass destruction. But the explosions over Hiroshima and Nagasaki not only made society more aware of the importance of science, they made scientists more aware of their responsibility to society. I describe the development of the concept of social responsibility and its appearance among American scientists both before and after the end of World War II.

  9. Association of topoisomerase II with the hepatoma cell nuclear matrix: the role of intermolecular disulfide bond formation.

    PubMed

    Kaufmann, S H; Shaper, J H

    1991-02-01

    Previous studies have resulted in conflicting data regarding the recovery of the nuclear enzymes topoisomerase (topo) II and topo I in the nuclear matrix fraction. In the present study we have assessed the effect of systematically altering a single extraction procedure on the distribution of these enzymes during the subfractionation of nuclei from HTC hepatoma tissue culture cells. When nuclear monolayers (prepared by treating attached cells in situ with the neutral detergent Nonidet-P40 at 4 degrees C) were isolated in the presence of the irreversible sulfhydryl blocking reagent iodoacetamide, subsequent treatment with DNase I and RNase A followed by 1.6 M NaCl resulted in structures which were extensively depleted of intranuclear components as assessed by phase contrast microscopy and conventional transmission electron microscopy. These structures contained 12 +/- 4% of the total protein present in the original nuclear monolayers. The lamins and polypeptides with molecular weights comparable to those of actin and vimentin were the predominant polypeptides present on SDS-polyacrylamide gels. Western blotting revealed that less than 5% of the total nuclear topo II molecules were present in these structures. In contrast, when the sulfhydryl cross-linking reagent sodium tetrathionate (NaTT) was substituted for iodoacetamide, the same extraction procedure yielded structures containing components of the nucleolus and an extensive intranuclear network. These structures contained a wide variety of nonlamin, nonhistone nuclear polypeptides including 23 +/- 4% of the total nuclear topo II. SDS-polyacrylamide gel electrophoresis performed under nonreducing conditions revealed that topo II in these nuclear matrices was present as part of a large disulfide cross-linked complex. Treatment of these structures with reducing agents in 1.6 M NaCl released the topo II. In contrast, topo I did not form disulfide cross-linked oligomers and was not detectable in any of these nuclease

  10. Optical Spectroscopy of Luminous Infrared Galaxies. II. Analysis of the Nuclear and Long-Slit Data

    NASA Astrophysics Data System (ADS)

    Veilleux, S.; Kim, D.-C.; Sanders, D. B.; Mazzarella, J. M.; Soifer, B. T.

    1995-05-01

    A spectroscopic survey of a sample of 200 luminous IRAS galaxies (LIGs: L_ir_^7^ > 3 x 10^10^ L_sun_; H_0_ = 75 km s^-1^ Mpc^-1^) was carried out using the Palomar 5 meter and University of Hawaii 2.2 m telescopes. Kim et al. (1995) described the data-taking and data-reduction procedures and presented line and continuum measurements extracted from the nucleus of these objects. In this paper, the nuclear data are combined with circumnuclear measurements on 23 of these galaxies to investigate the properties of the line-emitting gas and underlying stellar population in and out of the nucleus. The nuclear spectra of these galaxies were classified as H II region-like" or "AGN-like" using a large number of line-ratio diagnostics corrected for the underlying stellar absorption features. This correction is an important source of errors in some previous studies. The emission-line spectra of many AGNs were found to-be of relatively low ionization level and were therefore classified as LINER. We confirm that both the fraction of LIGs with AGN spectra and the fraction of Seyferts among the AGN increase with infrared luminosity, reaching values of 62% and 54% at the highest observed luminosities, respectively. The fraction of LINERs, on the other hand, is relatively constant at ~27%. The source of the ionization of the emission-line gas often is a function of the distance from the nucleus. Based on the emission-line ratios and the strengths of the stellar absorption features, circumnuclear starburst activity is a common feature of LIGs, regardless of their nuclear spectral types. The emission-line, absorption-line, continuum, radio, and IRAS properties of the LINERs suggest that most of the LINER emission in these infrared-selected galaxies is produced through shock ionization rather than photoionization by a genuine active nucleus. The nuclear region of Seyfert LIGs is found to be slightly less reddened than that of the LINERs and H II galaxies. The dust distribution generally

  11. Human GTPases associate with RNA polymerase II to mediate its nuclear import.

    PubMed

    Carré, Clément; Shiekhattar, Ramin

    2011-10-01

    Small GTPases share a biochemical mechanism and act as binary molecular switches. One important function of small GTPases in the cell is nucleocytoplasmic transport of both proteins and RNA. Here, we show the stable association of human GPN1 and GPN3, small GTPases related to Ran, with RNA polymerase II (RNAPII) isolated from either the cytoplasmic or nuclear fraction. GPN1 and GPN3 directly interact with RNAPII subunit 7 (RPB7)/RPB4 and the C-terminal domain (CTD) of RNAPII. Depletion of GPN1 or GPN3 using small interfering RNAs led to decreased RNAPII levels in the nucleus and an accumulation of this enzyme in the cytoplasm of human cells. Furthermore, isolation of a GPN1/GPN3/RNAPII complex from stable cell lines expressing a dominant negative GPN1 harboring mutations in the GTP-binding pocket demonstrated a role for these proteins in nuclear import of RNAPII. Thus, GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus.

  12. Measurement of Nuclear Recoils in the CDMS II Dark Matter Search

    NASA Astrophysics Data System (ADS)

    Fallows, Scott M.

    The Cryogenic Dark Matter Search (CDMS) experiment is designed to directly detect elastic scatters of weakly-interacting massive dark matter particles (WIMPs), on target nuclei in semiconductor crystals composed of Si and Ge. These scatters would occur very rarely, in an overwhelming background composed primarily of electron recoils from photons and electrons, as well as a smaller but non-negligible background of WIMP-like nuclear recoils from neutrons. The CDMS~II generation of detectors simultaneously measure ionization and athermal phonon signals from each scatter, allowing discrimination against virtually all electron recoils in the detector bulk. Pulse-shape timing analysis allows discrimination against nearly all remaining electron recoils taking place near detector surfaces. Along with carefully limited neutron backgrounds, this experimental program allowed for "background-free'' operation of CDMS~II at Soudan, with less than one background event expected in each WIMP-search analysis. As a result, exclusionary upper-limits on WIMP-nucleon interaction cross section were placed over a wide range of candidate WIMP masses, ruling out large new regions of parameter space. These results, like any others, are subject to a variety of systematic effects that may alter their final interpretations. A primary focus of this dissertation will be difficulties in precisely calibrating the energy scale for nuclear recoil events like those from WIMPs. Nuclear recoils have suppressed ionization signals relative to electron recoils of the same recoil energy, so the response of the detectors is calibrated differently for each recoil type. The overall normalization and linearity of the energy scale for electron recoils in CDMS~II detectors is clearly established by peaks of known gamma energy in the ionization spectrum of calibration data from a 133Ba source. This electron-equivalent keVee) energy scale enables calibration of the total phonon signal (keVt) by enforcing unity

  13. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    SciTech Connect

    Not Available

    1980-06-01

    The purpose of this volume is limited to an assessment of the relative effects that particular choices of nuclear-power systems, for whatever reasons, may have on the possible spread of nuclear-weapons capabilities. This volume addresses the concern that non-nuclear-weapons states may be able to initiate efforts to acquire or to improve nuclear-weapons capabilities through civilian nuclear-power programs; it also addresses the concern that subnational groups may obtain and abuse the nuclear materials or facilities of such programs, whether in nuclear-weapons states (NWS's) or nonnuclear-weapons states (NNW's). Accordingly, this volume emphasizes one important factor in such decisions, the resistance of nuclear-power systems to the proliferation of nuclear-weapons capabilities.

  14. Phase II: Field Detector Development For Undeclared/Declared Nuclear Testing For Treaty Verfiation Monitoring

    SciTech Connect

    Kriz, M.; Hunter, D.; Riley, T.

    2015-10-02

    Radioactive xenon isotopes are a critical part of the Comprehensive Nuclear Test Ban Treaty (CTBT) for the detection or confirmation of nuclear weapons tests as well as on-site treaty verification monitoring. On-site monitoring is not currently conducted because there are no commercially available small/robust field detector devices to measure the radioactive xenon isotopes. Xenon is an ideal signature to detect clandestine nuclear events since they are difficult to contain and can diffuse and migrate through soils due to their inert nature. There are four key radioxenon isotopes used in monitoring: 135Xe (9 hour half-life), 133mXe (2 day half-life), 133Xe (5 day half-life) and 131mXe (12 day half-life) that decay through beta emission and gamma emission. Savannah River National Laboratory (SRNL) is a leader in the field of gas collections and has developed highly selective molecular sieves that allow for the collection of xenon gas directly from air. Phase I assessed the development of a small, robust beta-gamma coincidence counting system, that combines collection and in situ detection methodologies. Phase II of the project began development of the custom electronics enabling 2D beta-gamma coincidence analysis in a field portable system. This will be a significant advancement for field detection/quantification of short-lived xenon isotopes that would not survive transport time for laboratory analysis.

  15. Civilian nuclear power on the drawing board: the development of Experimental Breeder Reactor-II.

    SciTech Connect

    Westfall, C.

    2003-02-20

    On September 28, 2001 a symposium was held at Argonne National Laboratory as part of the festivities to mark the 100th birthday of Enrico Fermi. The symposium celebrated Fermi's ''contribution to the development of nuclear power'' and focused on one particular ''line of development'' resulting from Fermi's interest in power reactors: Argonne's fast reactor program. Symposium participants made many references to the ways in which the program was linked to Fermi, who led the team which created the world's first self-sustaining nuclear chain reaction. For example, one presentation featured an April, 1944 memo that described a meeting attended by Fermi and others. The memo came from the time when research on plutonium and the nuclear chain reaction at Chicago's WWII Metallurgical Laboratory was nearing its end. Even as other parts of the Manhattan Engineering Project were building on this effort to create the bombs that would end the war, Fermi and his colleagues were taking the first steps to plan the use of nuclear energy in the postwar era. After noting that Fermi ''viewed the use of [nuclear] power for the heating of cities with sympathy,'' the group outlined several power reactor designs. In the course of discussion, Fermi and his colleagues took the first steps in conjuring the vision that would later be brought to life with Experimental Breeder Reactor I (EBR-I) and Experimental Breeder Reactor II (EBR-II), the celebrated achievements of the Argonne fast reactor program. Group members considered various schemes for a breeder reactor in which the relatively abundant U-238 would be placed near a core of fissionable material. The reactor would be a fast reactor; that is, neutrons would not be moderated, as were most wartime reactors. Thus, the large number of neutrons emitted in fast neutron fission would hit the U-238 and create ''extra'' fissionable material, that is, more than ''invested,'' and at the same time produce power. The group identified the problem of

  16. The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.

    PubMed Central

    Rihs, H P; Jans, D A; Fan, H; Peters, R

    1991-01-01

    We have previously demonstrated [Rihs, H.-P. and Peters, R. (1989) EMBO J., 8, 1479-1484] that the nuclear transport of recombinant proteins in which short fragments of the SV40 T-antigen are fused to the amino terminus of Escherichia coli beta-galactosidase is dependent on both the nuclear localization sequence (NLS, T-antigen residues 126-132) and a phosphorylation-site-containing sequence (T-antigen residues 111-125). While the NLS determines the specificity, the rate of transport is controlled by the phosphorylation-site-containing sequence. The present study furthers this observation and examines the role of the various phosphorylation sites. Purified, fluorescently labeled recombinant proteins were injected into the cytoplasm of Vero or hepatoma (HTC) cells and the kinetics of nuclear transport measured by laser microfluorimetry. By replacing serine and threonine residues known to be phosphorylated in vivo, we identified the casein kinase II (CK-II) site S111/S112 to be the determining factor in the enhancement of the transport. Either of the residues 111 or 112 was sufficient to elicit the maximum transport enhancement. The other phosphorylation sites (S120, S123, T124) had no influence on the transport rate. Examination of the literature suggested that many proteins harboring a nuclear localization sequence also contain putative CK-II sites at a distance of approximately 10-30 amino acid residues from the NLS. CK-II has been previously implicated in the transmission of growth signals to the nucleus. Our results suggest that CK-II may exert this role by controlling the rate of nuclear protein transport. Images PMID:1848177

  17. The Effect of Measurement Bias on Nuclear Criticality Safety Calculations for WIPP TRUPACT-II Shipments

    SciTech Connect

    Blackwood, Larry G.; Harker, Yale D.

    2000-12-15

    Current nuclear criticality safety limit requirements for transporting TRUPACT-II waste containers to the U.S. Department of Energy's Waste Isolation Pilot Plant (WIPP) specify that the {sup 239}Pu fissile gram equivalent (FGE) plus two times its measurement error must be {<=}325 g for a payload of fourteen 55-gal drums. The authorized method for calculating a TRUPACT-II FGE measurement error value is to take the square root of the sum of the squared error values for the individual containers (often called root-sum-squares or simply RSS). However, to the extent that the individual drum measurements contain common bias effects (e.g., due to common calibration or other adjustment factors), the corresponding measurement errors are correlated, and simple RSS calculations will underestimate the true error in the TRUPACT-II FGE value.The RSS calculations assume independence, while common bias effects can induce strong correlations between the errors in measurements. Significant bias effects can occur when the matrix characteristics for a particular waste type are not fully accounted for in the measurement process. Depending on the relative size of the bias error compared to precision error, the true measurement error can be greater than twice that calculated by RSS. In such cases, the FGE shipping requirement may not be met. To avoid underestimating the error, bias components should be estimated and propagated separately (combined only at the final step in the TRUPACT-II FGE calculation), or the effect of bias on covariance between measurements must be calculated. These covariance terms then need to be included in the final uncertainty calculations.

  18. Spectroscopic, thermal characterization and cytotoxic activity of bi-, tri- and tetra-nuclear Pd(II) and Pt(II) complexes with diSchiff base ligands

    NASA Astrophysics Data System (ADS)

    Hegazy, Wael Hussein

    2014-10-01

    In this paper; new di-, tri-, and tetra-nuclear Pd(II) and Pt(II) complexes of N,N‧-bis(3,4-dihydroxybenzylidene)ethan-1,2-diamine (EDH4), N,N‧-bis(3,4-dihydroxy-benzylidene)-benzene-1,2-diamine (PDH4) and N,N‧-bis-(3,4-dihydroxybenzylidene)-4,5-dimethyl-1,2-diamine (MPDH4) ligands were synthesized by two different methods. The first method involve the synthesis of the three ligands from condensation reaction of 3,4-dihydroxybenzaldehyde (L‧H2) with ethylenediamine (en), o-phenylenediamine (o-PD), or 4,5-dimethyl-1,2-phenylendiamine (DMPD) in a mole ratio of 2:1 followed by the reaction of the resulting Schiff bases ligands with Pd(II) or Pt(II) ions in the presence of 2,2‧-dipyridyl (L) to form the di- and tri-nuclear metal complexes. The second method involve the condensation of the Pd complex LPd(II)L‧, (L = 2,2‧-dipyridyl, L‧ = 4-formylbenzene-1,2-bis(olate)) with en, o-PD, or DMPD in a mole ratio of 2:1, respectively, followed by reaction with PdCl2 to form di-, tri-, and tetra-nuclear palladium(II) complexes, respectively. Structures of ligands and metal complexes are characterized by physical properties, FT-IR spectra and nuclear magnetic resonance. The geometries of metal complexes are suggested according to elemental analysis, electronic absorption spectra, thermal analysis, atomic absorption, magnetic susceptibility and molar conductance. Cytotoxic activity against lung large cell carcinoma (H460), prostate carcinoma (DU145), breast adenocarcinoma (MCF-7), amelanotic melanoma (M-14), colon adenocarcinoma (HT-29), and chronic myelogenous leukemia (K562) is also reported.

  19. Dynamic nuclear polarization system for the SANS-J-II spectrometer at JAEA

    NASA Astrophysics Data System (ADS)

    Kumada, Takayuki; Noda, Yohei; Hashimoto, Takeji; Koizumi, Satoshi

    2009-09-01

    We have developed a dynamic nuclear polarization (DNP) system for the SANS-J-II spectrometer at the JRR-3 atomic research reactor of Japan Atomic Energy Agency (JAEA). The DNP system is composed of a split-type horizontal superconducting magnet (3.3 T), a Gunn oscillator as a microwave source (94 GHz), and a cryostat (1.2 K). In particular, a sample cell with ∅40 in inner diameter and the magnet with a field homogeneity of 5×10 -5 in a volume of ∅25 mm×8 mm were employed to polarize samples with a diameter of ∅20 mm for the ultra small-angle scattering experiment using the magnetic lens installed at the SANS-J-II spectrometer [S. Koizumi, H. Iwase, J. Suzuki, T. Oku, R. Motokawa, H. Sasao, H. Tanaka, D. Yamaguchi, H.M. Shimizu, T. Hashimoto, J. Appl. Crystallogr. 40 (2007) s474]. We obtained the proton polarization | P|=32% in the polyethylene doped with 2,2,6,6-tetra-methyl-piperidine-1-oxyl (TEMPO).

  20. Measurement of Nuclear Recoils in the CDMS II Dark Matter Search

    SciTech Connect

    Fallows, Scott Mathew

    2014-12-01

    The Cryogenic Dark Matter Search (CDMS) experiment is designed to directly detect elastic scatters of weakly-interacting massive dark matter particles (WIMPs), on target nuclei in semiconductor crystals composed of Si and Ge. These scatters would occur very rarely, in an overwhelming background composed primarily of electron recoils from photons and electrons, as well as a smaller but non-negligible background of WIMP-like nuclear recoils from neutrons. The CDMS II generation of detectors simultaneously measure ionization and athermal phonon signals from each scatter, allowing discrimination against virtually all electron recoils in the detector bulk. Pulse-shape timing analysis allows discrimination against nearly all remaining electron recoils taking place near detector surfaces. Along with carefully limited neutron backgrounds, this experimental program allowed for \\background- free" operation of CDMS II at Soudan, with less than one background event expected in each WIMP-search analysis. As a result, exclusionary upper-limits on WIMP-nucleon interaction cross section were placed over a wide range of candidate WIMP masses, ruling out large new regions of parameter space.

  1. SNMSP II: A system to fully automate special nuclear materials accountability reporting for electric utilities

    SciTech Connect

    Pareto, V.; Venegas, R.

    1987-07-01

    The USNRC requires each licensee who is authorized to possess Special Nuclear Materials (SNM) to prepare and submit reports concerning SNM received, produced, possessed, transferred, consumed, disposed of, or lost. These SNM accountability reports, which need to be submitted twice a year, contain detailed information on the origin, quantity, and type of SNM for several locations. The amount of detail required makes these reports very time consuming and error prone when prepared manually. Yankee Atomic is developing an IBM PC-based computer code that fully automates the process of generating SNM accountability reports. The program, called SNMSP II, prints a number of summaries including facsimiles of the NRC/DOE-741, 742, 742C, and RW-859 reports in a format that can be submitted directly to the NRC/DOE. SNMSP II is menu-driven and is especially designed for people with little or no computer training. Input can be either from a mainframe-based corporate data base or manually through user-friendly screens. In addition, extensive quality assurance features are available to ensure the security and accuracy of the data. This paper discusses the major features of the code and describes its implementation at Yankee.

  2. Proliferating cell nuclear antigen, p53 and micro vessel density: Grade II vs. Grade III astrocytoma.

    PubMed

    Malhan, Priya; Husain, Nuzhat; Bhalla, Shalini; Gupta, Rakesh K; Husain, Mazhar

    2010-01-01

    Histological classification and grading are prime procedures in the management of patients with astrocytoma, providing vital data for therapeutic decision making and prognostication. However, it has limitations in assessing biological tumor behavior. This can be overcome by using newer immunohistochemical techniques. This study was carried out to compare proliferative indices using proliferating cell nuclear antigen (PCNA), extent of p53 expression and micro vessel morphometric parameters in patients with low grade and anaplastic astrocytoma. Twenty-five patients, each of grade II and grade III astrocytoma were evaluated using monoclonal antibodies to PCNA, p53 protein and factor VIII related antigen. PCNA, p53-labeling indices were calculated along with micro vessel morphometric analysis using Biovis Image plus Software. Patients with grade III astrocytoma had higher PCNA and p53 labeling indices as compared with grade II astrocytoma (29.14 plus/minus 9.87% vs. 16.84 plus/minus 6.57%, p 0.001; 18.18 plus/minus 6.14% vs. 6.14 plus/minus 7.23%, p 0.001, respectively). Micro vessel percentage area of patients with grade III astrocytoma was also (4.26 plus/minus 3.70 vs. 1.05 plus/minus 0.56, p 0.001), higher along with other micro vessel morphometric parameters. Discordance between histology and one or more IHC parameters was seen in 5/25 (20%) of patients with grade III astrocytoma and 9/25 (36%) of patients with grade II disease. PCNA and p53 labeling indices were positively correlated with Pearson's correlation, p less than 0.001 for both). Increased proliferative fraction, genetic alterations and neovascularization mark biological aggressiveness in astrocytoma. Immunohistochemical evaluation scores over meet the challenge of accurate prognostication of this potentially fatal malignancy.

  3. Tri- and tetra-nuclear polypyridyl ruthenium(II) complexes as antimicrobial agents.

    PubMed

    Gorle, Anil K; Feterl, Marshall; Warner, Jeffrey M; Wallace, Lynne; Keene, F Richard; Collins, J Grant

    2014-11-28

    A series of inert tri- and tetra-nuclear polypyridylruthenium(II) complexes that are linked by the bis[4(4'-methyl-2,2'-bipyridyl)]-1,n-alkane ligand ("bb(n)" for n = 10, 12 and 16) have been synthesised and their potential as antimicrobial agents examined. Due to the modular nature of the synthesis of the oligonuclear complexes, it was possible to make both linear and non-linear tetranuclear ruthenium species. The minimum inhibitory concentrations (MIC) of the ruthenium(II) complexes were determined against four strains of bacteria--Gram positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA), and Gram negative Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa). In order to gain an understanding of the relative antimicrobial activities, the cellular uptake and water-octanol partition coefficients (log P) were determined for a selection of the ruthenium complexes. Although the trinuclear complexes were the most lipophilic based upon log P values and showed the greatest cellular uptake, the linear tetranuclear complexes were generally more active, with MIC values <1 μM against the Gram positive bacteria. Similarly, although the non-linear tetranuclear complexes were slightly more lipophilic and were taken up to a greater extent by the bacteria, they were consistently less active than their linear counterparts. Of particular note, the cellular accumulation of the oligonuclear ruthenium complexes was greater in the Gram negative strains compared to that in the Gram positive S. aureus and MRSA. The results demonstrate that the lower antimicrobial activity of polypyridylruthenium(II) complexes towards Gram negative bacteria, particularly P. aeruginosa, is not strongly correlated to the cellular accumulation but rather to a lower intrinsic ability to kill the Gram negative cells.

  4. Cinnamaldehyde enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression in HepG2 cells.

    PubMed

    Huang, Tzou-Chi; Chung, Yu-Ling; Wu, Mei-Li; Chuang, Show-Mei

    2011-05-11

    Cinnamaldehyde has been demonstrated to stimulate glutathione production and the expression of phase II detoxifying enzymes in HepG2 cells. The mechanism underlying this cinnamaldehyde-mediated gene expression relies on Nrf2 transcriptional activity. Therefore, the molecular signaling events in cinnamaldehyde-mediated detoxifying enzyme expression were further investigated in this study. Cinnamaldehyde activated ERK1/2, Akt, and JNK signaling pathways, but not the p38 MAP kinase pathway, subsequently leading to Nrf2 nuclear translocation and eventually increasing phase II enzyme expression. In contrast, inhibition of ERK1/2, Akt, or JNK pathways attenuated Nrf2 nuclear translocation and phase II enzyme expression. Depletion of Nrf2 by small RNA interference (si-RNA) showed that the protein levels of phase II enzymes were no longer induced by cinnamaldehyde. A luciferase reporter assay and an electrophoretic mobility shift assay (EMSA) also demonstrated that cinnamaldehyde-activated signaling resulted in the increased transcriptional activity of Nrf2 through binding to the ARE4 enhancer sequence. Altogether, these data suggest that ERK1/2, Akt, and JNK pathways activated by cinnamaldehyde collectively control Nrf2 nuclear translocation and transcriptional activity, leading to the increase of phase II enzyme expression. Application of an appropriate chemopreventive agent such as cinnamaldehyde could potentially be an alternative strategy for cancer chemoprevention.

  5. Analysis of Radionuclide Releases from the Fukushima Dai-ichi Nuclear Power Plant Accident Part II

    NASA Astrophysics Data System (ADS)

    Achim, Pascal; Monfort, Marguerite; Le Petit, Gilbert; Gross, Philippe; Douysset, Guilhem; Taffary, Thomas; Blanchard, Xavier; Moulin, Christophe

    2014-03-01

    The present part of the publication (Part II) deals with long range dispersion of radionuclides emitted into the atmosphere during the Fukushima Dai-ichi accident that occurred after the March 11, 2011 tsunami. The first part (Part I) is dedicated to the accident features relying on radionuclide detections performed by monitoring stations of the Comprehensive Nuclear Test Ban Treaty Organization network. In this study, the emissions of the three fission products Cs-137, I-131 and Xe-133 are investigated. Regarding Xe-133, the total release is estimated to be of the order of 6 × 1018 Bq emitted during the explosions of units 1, 2 and 3. The total source term estimated gives a fraction of core inventory of about 8 × 1018 Bq at the time of reactors shutdown. This result suggests that at least 80 % of the core inventory has been released into the atmosphere and indicates a broad meltdown of reactor cores. Total atmospheric releases of Cs-137 and I-131 aerosols are estimated to be 1016 and 1017 Bq, respectively. By neglecting gas/particulate conversion phenomena, the total release of I-131 (gas + aerosol) could be estimated to be 4 × 1017 Bq. Atmospheric transport simulations suggest that the main air emissions have occurred during the events of March 14, 2011 (UTC) and that no major release occurred after March 23. The radioactivity emitted into the atmosphere could represent 10 % of the Chernobyl accident releases for I-131 and Cs-137.

  6. MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress

    SciTech Connect

    Preta, Giulio; Klark, Rainier de; Chakraborti, Shankhamala; Glas, Rickard

    2010-08-27

    Research highlights: {yields} Nuclear translocation of TPPII occurs in response to different DNA damage inducers. {yields} Nuclear accumulation of TPPII is linked to ROS and anti-oxidant enzyme levels. {yields} MAPKs control nuclear accumulation of TPPII. {yields} Inhibited nuclear accumulation of TPPII decreases DNA damage-induced {gamma}-H2AX expression. -- Abstract: Reactive oxygen species (ROS) are a continuous hazard in eukaroytic cells by their ability to cause damage to biomolecules, in particular to DNA. Previous data indicated that the cytosolic serine peptidase tripeptidyl-peptidase II (TPPII) translocates into the nucleus of most tumor cell lines in response to {gamma}-irradiation and ROS production; an event that promoted p53 expression as well as caspase-activation. We here observed that nuclear translocation of TPPII was dependent on signaling by MAP kinases, including p38MAPK. Further, this was caused by several types of DNA-damaging drugs, a DNA cross-linker (cisplatinum), an inhibitor of topoisomerase II (etoposide), and to some extent also by nucleoside-analogues (5-fluorouracil, hydroxyurea). In the minority of tumor cell lines where TPPII was not translocated into the nucleus in response to DNA damage we observed reduced intracellular ROS levels, and the expression levels of redox defense systems were increased. Further, treatment with the ROS-inducer {gamma}-hexa-chloro-cyclohexane ({gamma}-HCH, lindane), an inhibitor of GAP junctions, restored nuclear translocation of TPPII in these cell lines upon {gamma}-irradiation. Moreover, blocking nuclear translocation of TPPII in etoposide-treated cells, by using a peptide-derived inhibitor (Z-Gly-Leu-Ala-OH), attenuated expression of {gamma}-H2AX in {gamma}-irradiated melanoma cells. Our results indicated a role for TPPII in MAPK-dependent DNA damage signaling.

  7. INFORMATION: Inspection Report on "Removal of Categories I and II Special Nuclear Material from Sandia National Laboratories-New Mexico"

    SciTech Connect

    2010-01-01

    The Department of Energy's (DOE's) Sandia National Laboratories-New Mexico (Sandia) develops science-based technologies in support of national security in areas such as nuclear weapons, nonproliferation, military technologies, and homeland security. Sandia's primary mission is ensuring that the U.S. nuclear arsenal is safe, secure, and reliable and can fully support the Nation's deterrence policy. Part of this mission includes systems engineering of nuclear weapons; research, design, and development of non-nuclear components; manufacturing of non-nuclear weapons components; the provision of safety, security, and reliability assessments of stockpile weapons; and the conduct of high-explosives research and development and environmental testing. Sandia Corporation, a subsidiary of Lockheed Martin Corporation, operates Sandia for the National Nuclear Security Administration (NNSA). On May 7, 2004, the Secretary announced that the Department would evaluate missions at DOE sites to consolidate Special Nuclear Material (SNM) in the most secure environments possible. The Administrator of the NNSA said that this effort was a key part of an overall plan to transform the nuclear weapons complex into a smaller, safer, more secure, and more efficient national security enterprise. In February 2008, Sandia was the first site to report it had reduced its on-site inventory of nuclear material below 'Categories I and II' levels, which require the highest level of security to protect material such as plutonium and highly enriched uranium. The Office of Inspector General initiated an inspection to determine if Sandia made appropriate adjustments to its security posture in response to the removal of the Categories I and II SNM. We found that Sandia adjusted its security posture in response to the removal of Categories I and II SNM. For example, security posts were closed; unneeded protective force weapons and equipment were excessed from the site; and, Sandia's Site Safeguards and

  8. Assessment of RELAP5/MOD2 against a main feedwater turbopump trip transient in the Vandellos II Nuclear Power Plant

    SciTech Connect

    Llopis, C.; Casals, A.; Perez, J.; Mendizabal, R.

    1993-12-01

    The Consejo de Seguridad Nuclear (CSN) and the Asociacion Nuclear Vandellos (ANV) have developed a model of Vandellos II Nuclear Power Plant. The ANV collaboration consisted in the supply of design and actual data, the cooperation in the simulation of the control systems and other model components, as well as in the results analysis. The obtained model has been assessed against the following transients occurred in plant: A trip from the 100% power level (CSN); a load rejection from 100% to 50% (CSN); a load rejection from 75% to 65% (ANV); and, a feedwater turbopump trip (ANV). This copy is a report of the feedwater turbopump trip transient simulation. This transient actually occurred in the plant on June 19, 1989.

  9. Nuclear Geoplosics Sourcebook. Volume IV. Part II. Empirical Analysis of Nuclear and High-Explosive Cratering and Ejecta

    DTIC Science & Technology

    1979-03-01

    namely the coral atolls of Bikini and Enewetak . The NTS geology is sufficiertly diverse that cratering experiments have been conducted in four general...reexamination of six nuclear craters (IVY-MIKE, OAK, KOi SEMINOLE, LACROSSE, CACTUS) pfroduced at Enewetak Atoll in the early 1950’s wi performed by...water for the event. *For the most recent details on the geolo at the Enewetak Atoll craters (OAK, IVY-MIKE, KOA, SEMINOLE, LACROSSE, CACTUS), sc3

  10. Comparison of codes and neutron IC data used in US and Russia for the Topaz-II nuclear reactor assessment

    SciTech Connect

    Glushkov, Y.S.; Ponomarev-Stepnoi, N.N.; Kompanietz, G.V.; Gomin, Y.A.; Maiorov, L.V.; Lobynstev, V.A.; Polyakov, D.N.; Sapir, J.; Streetman, J.R.

    1993-11-01

    Topaz-II is a heterogeneous, epithermal reactor, fueled with highly enriched uranium-dioxide, cooled with NaK, and moderated with zirconium-hydride. The reactor core contains 37 single-cell thermionic fuel elements, and is surrounded by a radial beryllium reflector that contains 12 rotatable control drums with poison segments. For the physics analysis of TOPAZ II it is necessary to use the Monte Carlo method. The United States (US) and Russia used two different Monte Carlo codes, namely MCNP and MCU-2, respectively. The work described in this paper was aimed at comparing the codes and neutronic data used in the US and Russia for verification of Topaz-II nuclear safety. For this purpose, the US and Russia developed a joint benchmark model of the Topaz-II reactor. The American and Russian teams performed independent computations for a series of variants representing potential water immersion accidents. Comparison of the MCNP and MCU-2 codes showed somewhat different results both for the absolute values of k{sub eff} and for reactivity effects. Future calculations will be performed to obtain a detailed understanding of the reasons for such discrepancies. For these analyses it will be necessary for the US and Russian teams to exchange neutronic data on Topaz-II physics calculations.

  11. Analysis of TOPAZ II and SPACE-R space nuclear power plants using a modified thermionic model

    SciTech Connect

    Habedank, O.D.

    1993-03-01

    Models based on the TDS thermionic diode model were developed for the TOPAZ II and SPACE-R nuclear power systems. Due to computer code limitations inherent in the TDS model, only the TOPAZ II system model ran successfully. Several parameter studies were conducted on the TOPAZ II model. These studies determined system performance and efficiency while varying the following: (1) the coolant flow inlet temperatures; (2) the rate of coolant temperature change; (3) the power profile of the core; and (4) the cesium reservoir temperature. Analysis of the results indicate that the model accurately represented the TOPAZ II system, underestimating published data by 10%. Coolant flow parameter studies indicate that raising coolant flow temperatures up to 100 K higher increases system power by put to 5%. Additional increases in temperature result in gradual performance degradation. Varying the axial power profile of the core from the actual peaked profile to a flat profile results in a negligible 0.3% change in total system performance. The peaked profile used in TOPAZ II produces the highest system efficiency of all the profiles modeled. The cesium pressure study indicates that the system is operating above optimum cesium pressure and that system performance is strongly dependent on cesium pressure. Increasing cesium reservoir temperature above design temperature by 30 K decreases system efficiency by 30%.

  12. DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac.

    PubMed

    Wartlick, Friedrich; Bopp, Anita; Henninger, Christian; Fritz, Gerhard

    2013-12-01

    Here, we investigated the influence of Rac family small GTPases on mechanisms of the DNA damage response (DDR) stimulated by topoisomerase II poisons. To this end, we examined the influence of the Rac-specific small molecule inhibitor EHT1864 on Ser139 phosphorylation of histone H2AX, a widely used marker of the DDR triggered by DNA double-strand breaks. EHT1864 attenuated the doxorubicin-stimulated DDR in a subset of cell lines tested, including HepG2 hepatoma cells. EHT1864 reduced the level of DNA strand breaks and increased viability following treatment of HepG2 cells with topo II poisons. Protection by EHT1864 was observed in both p53 wildtype (HepG2) and p53 deficient (Hep3B) human hepatoma cells and, furthermore, remained unaffected upon pharmacological inhibition of p53 in HepG2. Apparently, the impact of Rac on the DDR is independent of p53. Protection from doxorubicin-induced DNA damage by EHT1864 comprises both S and G2 phase cells. The inhibitory effect of EHT1864 on doxorubicin-stimulated DDR was mimicked by pharmacological inhibition of various protein kinases, including JNK, ERK, PI3K, PAK and CK1. EHT1864 and protein kinase inhibitors also attenuated the formation of the topo II-DNA cleavable complex. Moreover, EHT1864 mitigated the constitutive phosphorylation of topoisomerase IIα at positions S1106, S1213 and S1247. Doxorubicin transport, nuclear import/export of topoisomerase II and Hsp90-related mechanisms are likely not of relevance for doxorubicin-stimulated DDR impaired by EHT1864. We suggest that multiple kinase-dependent but p53- and heat shock protein-independent Rac-regulated nuclear mechanisms are required for activation of the DDR following treatment with topo II poisons.

  13. Rubisco in marine symbiotic dinoflagellates: form II enzymes in eukaryotic oxygenic phototrophs encoded by a nuclear multigene family.

    PubMed Central

    Rowan, R; Whitney, S M; Fowler, A; Yellowlees, D

    1996-01-01

    Genes encoding ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) were cloned from dinoflagellate symbionts (Symbiodinium spp) of the giant clam Tridacna gigas and characterized. Strikingly, Symbiodinium Rubisco is completely different from other eukaryotic (form I) Rubiscos: it is a form II enzyme that is approximately 65% identical to Rubisco from Rhodospirillum rubrum (Rubisco forms I and II are approximately 25 to 30% identical); it is nuclear encoded by a multigene family; and the predominantly expressed Rubisco is encoded as a precursor polyprotein. One clone appears to contain a predominantly expressed Rubisco locus (rbcA), as determined by RNA gel blot analysis of Symbiodinium RNA and sequencing of purified Rubisco protein. Another contains an enigmatic locus (rbcG) that exhibits an unprecedented pattern of amino acid replacement but does not appear to be a pseudogene. The expression of rbcG has not been analyzed; it was detected only in the minor of two taxa of Symbiodinium that occur together in T. gigas. This study confirms and describes a previously unrecognized branch of Rubisco's evolution: a eukaryotic form II enzyme that participates in oxygenic photosynthesis and is encoded by a diverse, nuclear multigene family. PMID:8721755

  14. Localization of human T-cell lymphotropic virus type II Tax protein is dependent upon a nuclear localization determinant in the N-terminal region.

    PubMed

    Turci, Marco; Romanelli, Maria Grazia; Lorenzi, Pamela; Righi, Paola; Bertazzoni, Umberto

    2006-01-03

    Human T-cell lymphotropic viruses (HTLV) types I and II are closely related oncogenic retroviruses that have been associated with lymphoproliferative and neurological disorders. The proviral genome encodes a trans-regulatory Tax protein that activates viral genes and upregulates various cellular genes involved in both cell growth and transformation. Tax proteins of HTLV-I (Tax-I) and HTLV-II (Tax-II) exhibit more than 77% aa homology and expression of either Tax-I or Tax-II is sufficient for immortalization of cultured T lymphocytes. Tax-I shuttles from the nucleus to the cytoplasm and accumulates within the nucleus, whereas Tax-II is found mainly in the cytoplasm. In the present study we have used recombinant vectors to analyze the size and structure of the nuclear localization domain within the Tax-II protein sequence. The Tax-II protein was expressed in HeLa cells either as the complete protein, or regions thereof, that were individually fused to the green fluorescent protein (GFP). Immunoblot analysis of the fused Tax-II products confirmed their expression and size. Fluorescence microscopy studies indicated that the complete Tax-II as well as N-truncated forms presented a punctuate cytoplasmic distribution and that a nuclear localization determinant is confined to within the first 60 aa of Tax-II. Accordingly, site directed mutagenesis and deletion of specific sequences within the first 60 aa showed that the nuclear determinant lies within the first 41 residues of Tax-II. These results point to a direct involvement of the amino-terminal residues of Tax-II protein in determining its nuclear functionality.

  15. Nuclear Thermal Rocket Element Environmental Simulator (NTREES) Phase II Upgrade Activities

    NASA Technical Reports Server (NTRS)

    Emrich, William J.; Moran, Robert P.; Pearson, J. Bose

    2013-01-01

    To support the on-going nuclear thermal propulsion effort, a state-of-the-art non nuclear experimental test setup has been constructed to evaluate the performance characteristics of candidate fuel element materials and geometries in representative environments. The facility to perform this testing is referred to as the Nuclear Thermal Rocket Element Environment Simulator (NTREES). This device can simulate the environmental conditions (minus the radiation) to which nuclear rocket fuel components will be subjected during reactor operation. Test articles mounted in the simulator are inductively heated in such a manner so as to accurately reproduce the temperatures and heat fluxes which would normally occur as a result of nuclear fission and would be exposed to flowing hydrogen. Initial testing of a somewhat prototypical fuel element has been successfully performed in NTREES and the facility has now been shutdown to allow for an extensive reconfiguration of the facility which will result in a significant upgrade in its capabilities. Keywords: Nuclear Thermal Propulsion, Simulator

  16. Analysis of TOPAZ II and SPACE-R space nuclear power plants using a modified thermionic model. Master's thesis

    SciTech Connect

    Habedank, O.D.

    1993-03-01

    Models based on the TDS thermionic diode model were developed for TOPAZ II and SPACER nuclear power systems. Several parameter studies were conducted with the TOPAZ II model. These determined system performance and efficiency while varying the following: (1) Coolant flow inlet temperatures. (2) Rate of coolant temperature change. (3) Power profile of the core. (4) Cesium reservoir temperature. Analysis of results indicate the model accurately represented the TOPAZ II system, underestimating published data by 10%. Coolant flow studies indicate that raising coolant temperatures up to 100 K higher increases system power by up to 5%. Additional increases in temperature result in gradual performance degradation. Varying the axial power profile of the core from the actual peaked profile to a flat profile results in a negligible 0.3% change in system performance. The peaked profile used in TOPAZ II produces the highest system efficiency of all the profiles modeled. The cesium pressure study indicates the system is operating above optimum cesium pressure and system performance is strongly dependent on cesium pressure. Increasing cesium reservoir temperature above design temperature by 30 K decreases system efficiency by 30%.

  17. A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses

    SciTech Connect

    Preta, Giulio; Klark, Rainier de; Glas, Rickard

    2009-11-27

    Responses to DNA damage are influenced by cellular metabolism through the continuous production of reactive oxygen species (ROS), of which most are by-products of mitochondrial respiration. ROS have a strong influence on signaling pathways during responses to DNA damage, by relatively unclear mechanisms. Previous reports have shown conflicting data on a possible role for tripeptidyl-peptidase II (TPPII), a large cytosolic peptidase, within the DNA damage response. Here we show that TPPII translocated into the nucleus in a p160-ROCK-dependent fashion in response to {gamma}-irradiation, and that nuclear expression of TPPII was present in most {gamma}-irradiated transformed cell lines. We used a panel of nine cell lines of diverse tissue origin, including four lymphoma cell lines (T, B and Hodgkins lymphoma), a melanoma, a sarcoma, a colon and two breast carcinomas, where seven out of nine cell lines showed nuclear TPPII expression after {gamma}-irradiation. Further, this required cellular production of ROS; treatment with either N-acetyl-Cysteine (anti-oxidant) or Rotenone (inhibitor of mitochondrial respiration) inhibited nuclear accumulation of TPPII. The local density of cells was important for nuclear accumulation of TPPII at early time-points following {gamma}-irradiation (at 1-4 h), indicating a bystander effect. Further, we showed that the peptide-based inhibitor Z-Gly-Leu-Ala-OH, but not its analogue Z-Gly-(D)-Leu-Ala-OH, excluded TPPII from the nucleus. This correlated with reduced nuclear expression of p53 as well as caspase-3 and -9 activation in {gamma}-irradiated lymphoma cells. Our data suggest a role for TPPII in ROS-dependent DNA damage responses, through alteration of its localization from the cytosol into the nucleus.

  18. Spiral Galaxies with HST/NICMOS. II. Isophotal Fits and Nuclear Cusp Slopes

    NASA Astrophysics Data System (ADS)

    Seigar, Marc; Carollo, C. Marcella; Stiavelli, Massimo; de Zeeuw, P. Tim; Dejonghe, Herwig

    2002-01-01

    We present surface brightness profiles for 56 of the 78 spiral galaxies observed in the HST/NICMOS2 F160W snapshot survey introduced in Paper I of this series, as well as surface brightness profiles for 23 objects out of the 41 that were also observed in the F110W filter. We fit these surface brightness profiles with the Nuker law of Lauer et al. and use the smooth analytical descriptions of the data to compute the average nuclear stellar cusp slopes <γ> in the 0.1"-0.5" radial range. Our main result is the startling similarity between the nuclear stellar cusp slopes <γ> in the near-infrared compared with those derived in the visual passband. This similarity has several implications: (1) Despite the significant local color variations that are found in the nuclear regions of spirals and that are documented in Paper I, there are typically little or no optical-NIR global color gradients, and thus no global stellar population variations, inside ~50-100 pc from the nucleus in nearby spirals. (2) The large observed range of the strength of the nuclear stellar cusps seen in the HST optical study of spiral galaxies reflects a physical difference between galaxies and is not an artifact caused by nuclear dust and/or recent star formation. (3) The dichotomy between R1/4 bulges, with steep nuclear stellar cusps <γ>~1, and exponential bulges, with shallow nuclear stellar cusps <γ><0.3, is also not an artifact of the effects of dust or recent star formation. (4) The presence of a surrounding massive disk appears to have no effect on the rise of the stellar density distribution within the innermost hundred parsecs of the R1/4 spheroids. These results imply a breakdown within the family of exponential bulges of the nuclear versus global relationships that have been found for the R1/4 spheroids. Such a breakdown is likely to have significant implications concerning the formation of exponential bulges and their connection with the R1/4 spheroids. Based on observations with the

  19. Nuclear abnormalities in buccal mucosa cells of patients with type I and II diabetes treated with folic acid.

    PubMed

    Gómez-Meda, B C; Zamora-Perez, A L; Muñoz-Magallanes, T; Sánchez-Parada, M G; García Bañuelos, J J; Guerrero-Velázquez, C; Sánchez-Orozco, L V; Vera-Cruz, J M; Armendáriz-Borunda, J; Zúñiga-González, G M

    2016-02-01

    Diabetes mellitus (DM) is characterized by high blood glucose. Excessive production of free radicals may cause oxidative damage to DNA and other molecules, leading to complications of the disease. It may be possible to delay or reduce such damage by administration of antioxidants such as folic acid (FA). The objective of this study was to determine the effect of FA on nuclear abnormalities (NAs) in the oral mucosa of patients with DM. NAs (micronucleated cells, binucleated cells, pyknotic nuclei, karyorrhexis, karyolysis, abnormally condensed chromatin, and nuclear buds) were analyzed in 2000 cells from 45 healthy individuals (control group) and 55 patients with controlled or uncontrolled type I or II DM; 35 patients in the latter group were treated with FA. Samples were taken from the FA group before and after treatment. An increased rate of NAs was found in patients with DM in comparison with that of the control group (P<0.001). FA supplementation in patients with DM reduced the frequency of NAs (20.4 ± 8.0 before treatment vs. 10.5 ± 5.2 after treatment; P<0.001). The type I and type II DM and controlled and uncontrolled DM subgroups were analyzed in terms of sex, age, and smoking habit. The significantly reduced frequencies of buccal mucosa cells with micronuclei, binucleation, pyknosis, karyorrhexis, karyorrhexis+abnormally condensed chromatin, karyolysis, and nuclear buds produced by FA supplementation in DM patients (P<0.02) are consistent with the idea that free radicals are responsible for the increased frequency of NAs in DM patients.

  20. Accidental Nuclear War: The Growing Peril. Part I [and] Part II.

    ERIC Educational Resources Information Center

    Newcombe, Alan, Ed.

    1984-01-01

    Two volumes designed to increase awareness of accidental nuclear war dangers are presented. The first of 5 sections in volume I proposes that although accidental war is preventable, the current arms race and secrecy about accidents and false alarms increase the possibility of an accidental war. Section 2 posits that decreased decision-making time…

  1. Two distinct nuclear factors bind the conserved regulatory sequences of a rabbit major histocompatibility complex class II gene.

    PubMed Central

    Sittisombut, N

    1988-01-01

    The constitutive coexpression of the major histocompatibility complex (MHC) class II genes in B lymphocytes requires positive, trans-acting transcriptional factors. The need for these trans-acting factors has been suggested by the reversion of the MHC class II-negative phenotype of rare B-lymphocyte mutants through somatic cell fusion with B cells or T-cell lines. The mechanism by which the trans-acting factors exert their effect on gene transcription is unknown. The possibility that two highly conserved DNA sequences, located 90 to 100 base pairs (bp) (the A sequence) and 60 to 70 bp (the B sequence) upstream of the transcription start site of the class II genes, are recognized by the trans-acting factors was investigated in this study. By using the gel electrophoresis retardation assay, a minimum of two proteins which specifically bound the conserved A or B sequence of a rabbit DP beta gene were identified in murine nuclear extracts of a B-lymphoma cell line, A20-2J. Fractionation of nuclear extract through a heparin-agarose column allowed the identification of one protein, designated NF-MHCIIB, which bound an oligonucleotide containing the B sequence and protected the entire B sequence in the DNase I protection analysis. Another protein, designated NF-MHCIIA, which bound an oligonucleotide containing the A sequence and partially protected the 3' half of this sequence, was also identified. NF-MHCIIB did not protect a CCAAT sequence located 17 bp downstream of the B sequence. The possible relationship between these DNA-binding factors and the trans-acting factors identified in the cell fusion experiments is discussed. Images PMID:3133552

  2. Description of induced nuclear fission with Skyrme energy functionals. II. Finite temperature effects

    NASA Astrophysics Data System (ADS)

    Schunck, N.; Duke, D.; Carr, H.

    2015-03-01

    Understanding the mechanisms of induced nuclear fission for a broad range of neutron energies could help resolve fundamental science issues, such as the formation of elements in the universe, but could have also a large impact on societal applications in energy production or nuclear waste management. The goal of this paper is to set up the foundations of a microscopic theory to study the static aspects of induced fission as a function of the excitation energy of the incident neutron, from thermal to fast neutrons. To account for the high excitation energy of the compound nucleus, we employ a statistical approach based on finite temperature nuclear density functional theory with Skyrme energy densities, which we benchmark on the 239Pu(n ,f ) reaction. We compute the evolution of the least-energy fission pathway across multidimensional potential energy surfaces with up to five collective variables as a function of the nuclear temperature and predict the evolution of both the inner and the outer fission barriers as a function of the excitation energy of the compound nucleus. We show that the coupling to the continuum induced by the finite temperature is negligible in the range of neutron energies relevant for many applications of neutron-induced fission. We prove that the concept of quantum localization introduced recently can be extended to T >0 , and we apply the method to study the interaction energy and total kinetic energy of fission fragments as a function of the temperature for the most probable fission. While large uncertainties in theoretical modeling remain, we conclude that a finite temperature nuclear density functional may provide a useful framework to obtain accurate predictions of fission fragment properties.

  3. Analytical mass formula and nuclear surface properties in the ETF approximation. Part II: asymmetric nuclei

    NASA Astrophysics Data System (ADS)

    Aymard, François; Gulminelli, Francesca; Margueron, Jérôme

    2016-08-01

    We have recently addressed the problem of the determination of the nuclear surface energy for symmetric nuclei in the framework of the extended Thomas-Fermi (ETF) approximation using Skyrme functionals. We presently extend this formalism to the case of asymmetric nuclei and the question of the surface symmetry energy. We propose an approximate expression for the diffuseness and the surface energy. These quantities are analytically related to the parameters of the energy functional. In particular, the influence of the different equation of state parameters can be explicitly quantified. Detailed analyses of the different energy components (local/non-local, isoscalar/isovector, surface/curvature and higher order) are also performed. Our analytical solution of the ETF integral improves previous models and leads to a precision of better than 200 keV per nucleon in the determination of the nuclear binding energy for dripline nuclei.

  4. PROTEINS IN NUCLEOCYTOPLASMIC INTERACTIONS : II. Turnover and Changes in Nuclear Protein Distribution with Time and Growth.

    PubMed

    Goldstein, L; Prescott, D M

    1968-01-01

    In previous studies, we showed that essentially all the proteins of the Amoeba proteus nucleus could be classified either as Rapidly Migrating Proteins (RMP), which shuttle between nucleus and cytoplasm continuously at a relatively rapid rate during interphase, or as Slow Turnover Proteins (STP), which seem to move hardly at all during interphase. In this paper, we report on the kinetics and direction of the movement of both classes of protein, as well as on aspects of their localization, with and without growth. The effects of growth were observed with and without cell division. These nuclear proteins have been studied in several ways: by transplantation of labeled nuclei into unlabeled cells and noting the rate of distribution to cytoplasm and host cell nuclei; by repeated amputation of cytoplasm from labeled cells-with and without initially labeled cytoplasm-each amputation being followed by refeeding on unlabeled food; by noting the redistribution of the various protein classes following growth and cell division. The data show (a) labeled RMP equilibrate between a grafted labeled nucleus and an unlabeled host nucleus in ca. 3 hr, but are detectable in the latter less than 30 min after the operation; (b) STP label does, indeed, leave the nucleus and does so at a rate of ca. 25% of the nuclear total per cell generation (ca. 36-40 hr at 23 degrees C); (c) the cytoplasm appears to have a reserve of material that is converted to RMP; (d) when labeled cells are amputated just before they would have divided and are refed unlabeled food after each amputation, there is a loss of 20-25% of the nuclear protein label with each amputation; (e) under the latter circumstances, an essentially complete turnover of all nuclear protein can be demonstrated.

  5. Investigation of injury/illness data at a nuclear facility. Part II

    SciTech Connect

    Cournoyer, Michael E.; Garcia, Vincent E.; Sandoval, Arnold N.; George, Gerald L.; Gubernatis, David C.; Schreiber, Stephen B.

    2015-07-01

    At Los Alamos National Laboratory (LANL), there are several nuclear facilities, accelerator facilities, radiological facilities, explosives sites, moderate- and high-hazard non-nuclear facilities, biosciences laboratory, etc. The Plutonium Science and Manufacturing Directorate (ADPSM) provides special nuclear material research, process development, technology demonstration, and manufacturing capabilities. ADPSM manages the LANL Plutonium Facility. Within the Radiological Control Area at TA-55 (PF-4), chemical and metallurgical operations with plutonium and other hazardous materials are performed. LANL Health and Safety Programs investigate injury and illness data. In this study, statistically significant trends have been identified and compared for LANL, ADPSM, and PF-4 injury/illness cases. A previously described output metric is used to measures LANL management progress towards meeting its operational safety objectives and goals. Timelines are used to determine trends in Injury/Illness types. Pareto Charts are used to prioritize causal factors. The data generated from analysis of Injury/Illness data have helped identify and reduce the number of corresponding causal factors.

  6. Investigation of injury/illness data at a nuclear facility. Part II

    DOE PAGES

    Cournoyer, Michael E.; Garcia, Vincent E.; Sandoval, Arnold N.; ...

    2015-07-01

    At Los Alamos National Laboratory (LANL), there are several nuclear facilities, accelerator facilities, radiological facilities, explosives sites, moderate- and high-hazard non-nuclear facilities, biosciences laboratory, etc. The Plutonium Science and Manufacturing Directorate (ADPSM) provides special nuclear material research, process development, technology demonstration, and manufacturing capabilities. ADPSM manages the LANL Plutonium Facility. Within the Radiological Control Area at TA-55 (PF-4), chemical and metallurgical operations with plutonium and other hazardous materials are performed. LANL Health and Safety Programs investigate injury and illness data. In this study, statistically significant trends have been identified and compared for LANL, ADPSM, and PF-4 injury/illness cases. A previouslymore » described output metric is used to measures LANL management progress towards meeting its operational safety objectives and goals. Timelines are used to determine trends in Injury/Illness types. Pareto Charts are used to prioritize causal factors. The data generated from analysis of Injury/Illness data have helped identify and reduce the number of corresponding causal factors.« less

  7. Synthesis, structure, and magnetic properties of (6-9)-nuclear Ni(II) trimethylacetates and their heterospin complexes with nitroxides.

    PubMed

    Ovcharenko, Victor; Fursova, Elena; Romanenko, Galina; Eremenko, Igor; Tretyakov, Evgeny; Ikorskii, Vladimir

    2006-07-10

    New polynuclear nickel trimethylacetates [Ni6(OH)4(C5H9O2)8(C5H10O2)4] (6), [Ni7(OH)7(C5H9O2)7(C5H10O2)6(H2O)] x 0.5 C6H14 x 0.5 H2O (7), [Ni8(OH)4(H2O)2(C5H9O2)12] (8), and [Ni9(OH)6(C5H9O2)12(C5H10O2)4] x C5H10O2 x 3 H2O (9), where C5H9O2 is trimethylacetate and C5H10O2 is trimethylacetic acid, have been found. Their structures were determined by X-ray crystallography. Because of their high solubility in low-polarity organic solvents, compounds 6-9 reacted with stable organic radicals to form the first heterospin compounds based on polynuclear Ni(II) trimethylacetate and nitronyl nitroxides containing pyrazole (L(1)-L(3)), methyl (L(4)), or imidazole (L(5)) substituent groups, respectively, in side chain [Ni7(OH)5(C5H9O2)9(C5H10O2)2(L(1))2(H2O)] x 0.5 C6H14 x H2O (6+1a), [Ni7(OH)5(C5H9O2)9(C5H10O2)2(L2)2(H2O)] x H2O (6+1b), [Ni7(OH)5(C5H9O2)9(C5H10O2)2(L(3))2(H2O)] x H2O (6+1c), [Ni6(OH)3(C5H9O2)9(C5H10O2)4(L(4))] x 1.5 C6H14 (6''), and [Ni4OH)3(C5H9O2)5(C5H10O2)4(L(5))] x 1.5 C7H8 (4). Their structures were also determined by X-ray crystallography. Although Ni(II) trimethylacetates may have varying nuclearity and can change their nuclearity during recrystallization or interactions with nitroxides, this family of compounds is easy to study because of its topological relationship. For any of these complexes, the polynuclear framework may be derived from the [Ni6] polynuclear fragment {Ni6(mu4-OH)2(mu3-OH)2(mu2-C5H9O2-O,O')6(mu2-C5H9O2-O,O)(mu4-C5H9O2-O,O,O',O')(C5H10O2)4}, which is shaped like an open book. On the basis of this fragment, the structure of 7-nuclear compounds (7 and 6+1a-c) is conveniently represented as the result of symmetric addition of other mononuclear fragments to the four Ni(II) ions lying at the vertexes of the [Ni6] open book. The 9-nuclear complex is formed by the addition of trinuclear fragments to two Ni(II) ions lying on one of the lateral edges of the [Ni6] open book. This wing of the 9-nuclear complex preserves its structure in

  8. A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription

    PubMed Central

    1991-01-01

    An antibody was identified previously that recognizes sites of polymerase II transcription on lampbrush chromosomes, puffs on polytene chromosomes, and many small granules in the nucleoplasm of all cells tested. This antibody binds a conserved family of phosphorylated polypeptides in vertebrate and invertebrate cells. We developed a method for purifying these proteins that involves differential solubility in MgCl2. We isolated a Drosophila cDNA encoding one of the proteins using information obtained from microsequencing. In vivo expression studies show that this protein is concentrated on sites of polymerase II transcription and that it is highly phosphorylated. The protein shares a high degree of homology with proteins involved in alternative splicing of pre-mRNA suggesting the possibility that this protein plays a role in pre-mRNA splicing. PMID:1717489

  9. Nuclear inelastic scattering study of a dinuclear iron(II) complex showing a direct spin transition

    NASA Astrophysics Data System (ADS)

    Wolny, J. A.; Garcia, Y.; Faus, I.; Rackwitz, S.; Schlage, K.; Wille, H.-C.; Schünemann, V.

    2016-12-01

    The results of the nuclear inelastic scattering (NIS)/nuclear resonance vibrational spectroscopy (NRVS) for the powder spectra of dimeric [Fe 2 L 5(NCS) 4] (L = N-salicylidene-4-amino-1,2,4-triazole) complex are presented. This system is spin crossover (SCO) material tagged with a fluorophore that can sense or "feel" the SCO signal ripping through the molecular network and thereby providing an opportunity to register the SCO transition. The spectra have been measured for the low-spin and high-spin phases of the complex. The high-spin isomer reveals one broad band above 200 cm -1, while the low-spin one displays two intense bands in the range from 390 to 430 cm -1, accompanied by a number of weaker bands below this area and one at ca. 490 cm -1. A normal coordinate analysis based on density functional calculations yields the assignment of the spin marker bands to particular molecular modes. In addition the vibrational contribution to the spin transition has been estimated

  10. Theory and Implementation of Nuclear Safety System Codes - Part II: System Code Closure Relations, Validation, and Limitations

    SciTech Connect

    Glenn A Roth; Fatih Aydogan

    2014-09-01

    This is Part II of two articles describing the details of thermal-hydraulic sys- tem codes. In this second part of the article series, the system code closure relationships (used to model thermal and mechanical non-equilibrium and the coupling of the phases) for the governing equations are discussed and evaluated. These include several thermal and hydraulic models, such as heat transfer coefficients for various flow regimes, two phase pressure correlations, two phase friction correlations, drag coefficients and interfacial models be- tween the fields. These models are often developed from experimental data. The experiment conditions should be understood to evaluate the efficacy of the closure models. Code verification and validation, including Separate Effects Tests (SETs) and Integral effects tests (IETs) is also assessed. It can be shown from the assessments that the test cases cover a significant section of the system code capabilities, but some of the more advanced reactor designs will push the limits of validation for the codes. Lastly, the limitations of the codes are discussed by considering next generation power plants, such as Small Modular Reactors (SMRs), analyz- ing not only existing nuclear power plants, but also next generation nuclear power plants. The nuclear industry is developing new, innovative reactor designs, such as Small Modular Reactors (SMRs), High-Temperature Gas-cooled Reactors (HTGRs) and others. Sub-types of these reactor designs utilize pebbles, prismatic graphite moderators, helical steam generators, in- novative fuel types, and many other design features that may not be fully analyzed by current system codes. This second part completes the series on the comparison and evaluation of the selected reactor system codes by discussing the closure relations, val- idation and limitations. These two articles indicate areas where the models can be improved to adequately address issues with new reactor design and development.

  11. Radiation effects in concrete for nuclear power plants, Part II: Perspective from micromechanical modeling

    SciTech Connect

    Le Pape, Yann; Field, Kevin G.; Remec, Igor

    2014-11-15

    The need to understand and characterize the effects of neutron irradiation on concrete has become urgent because of the possible extension of service life of many nuclear power generating stations. Current knowledge is primarily based on a collection of data obtained in test reactors. These results are inherently difficult to interpret because materials and testing conditions are inconsistent. A micromechanical approach based on the Hashin composite sphere model is presented to derive a first-order separation of the effects of radiation on cement paste and aggregate, and, also, on their interaction. Although the scarcity of available data limits the validation of the model, it appears that, without negating a possible gamma-ray induced effect, the neutron-induced damage and swelling of aggregate plays a predominant role on the overall concrete expansion and the damage of the cement paste. Finally, the radiation-induced volumetric expansion (RIVE) effects can also be aided by temperature elevation and shrinkage in the cement paste.

  12. A probabilistic seismic risk assessment procedure for nuclear power plants: (II) Application

    USGS Publications Warehouse

    Huang, Y.-N.; Whittaker, A.S.; Luco, N.

    2011-01-01

    This paper presents the procedures and results of intensity- and time-based seismic risk assessments of a sample nuclear power plant (NPP) to demonstrate the risk-assessment methodology proposed in its companion paper. The intensity-based assessments include three sets of sensitivity studies to identify the impact of the following factors on the seismic vulnerability of the sample NPP, namely: (1) the description of fragility curves for primary and secondary components of NPPs, (2) the number of simulations of NPP response required for risk assessment, and (3) the correlation in responses between NPP components. The time-based assessment is performed as a series of intensity-based assessments. The studies illustrate the utility of the response-based fragility curves and the inclusion of the correlation in the responses of NPP components directly in the risk computation. ?? 2011 Published by Elsevier B.V.

  13. SPATIALLY RESOLVED CHEMISTRY IN NEARBY GALAXIES. II. THE NUCLEAR BAR IN MAFFEI 2

    SciTech Connect

    Meier, David S.; Turner, Jean L. E-mail: turner@astro.ucla.edu

    2012-08-20

    We present 2''-10'' imaging of 11 transitions from 9 molecular species across the nuclear bar in Maffei 2. The data were obtained with the BIMA and OVRO interferometers. The 10 detected transitions are compared with existing CO isotopologues, HCN, CS, and millimeter continuum data. Dramatic spatial variations among the mapped species are observed across the nuclear bar. A principal component analysis is performed to characterize correlations between the transitions, star formation, and molecular column density. The analysis reveals that HCN, HNC, HCO{sup +}, and 3 mm continuum are tightly correlated, indicating a direct connection to massive star formation. We find two main morphologically distinct chemical groups, CH{sub 3}OH, SiO, and HNCO comprising the grain chemistry molecules, versus HCN, HNC, HCO{sup +}, and C{sub 2}H, molecules strong in the presence of star formation. The grain chemistry molecules, HNCO, CH{sub 3}OH, and SiO, trace hydrodynamical bar shocks. The near constancy of the HNCO/CH{sub 3}OH, SiO/CH{sub 3}OH, and SiO/HNCO ratios argues that shock properties are uniform across the nucleus. HCN/HCO{sup +}, HCN/HNC, HCN/CS, and HCN/CO ratios are explained primarily by variations in density. High HCO{sup +}/N{sub 2}H{sup +} ratios are correlated with the C{sub 2}H line, suggesting that this ratio may be a powerful new dense photon-dominated region probe in external galaxies. C{sub 2}H reveals a molecular outflow along the minor axis. The morphology and kinematics of the outflow are consistent with an outflow age of 6-7 Myr.

  14. The nuclear region of low luminosity flat radio spectrum sources. II. Emission-line spectra

    NASA Astrophysics Data System (ADS)

    Gonçalves, A. C.; Serote Roos, M.

    2004-01-01

    We report on the spectroscopic study of 19 low luminosity Flat Radio Spectrum (LL FRS) sources selected from Marchã's et al. (\\cite{March96}) 200 mJy sample. In the optical, these objects are mainly dominated by the host galaxy starlight. After correcting the data for this effect, we obtain a new set of spectra clearly displaying weak emission lines; such features carry valuable information concerning the excitation mechanisms at work in the nuclear regions of LL FRS sources. We have used a special routine to model the spectra and assess the intensities and velocities of the emission lines; we have analyzed the results in terms of diagnostic diagrams. Our analysis shows that 79% of the studied objects harbour a Low Ionization Nuclear Emission-line Region (or LINER) whose contribution was swamped by the host galaxy starlight. The remaining objects display a higher ionization spectrum, more typical of Seyferts; due to the poor quality of the spectra, it was not possible to identify any possible large Balmer components. The fact that we observe a LINER-type spectrum in LL FRS sources supports the idea that some of these objects could be undergoing an ADAF phase; in addition, such a low ionization emission-line spectrum is in agreement with the black hole mass values and sub-Eddington accretion rates published for some FRS sources. Based on observations collected at the Multiple Mirror Telescope on Mt. Hopkins. Full Fig. 1 is only available in electronic form at http://www.edpsciences.org

  15. Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling.

    PubMed

    Illi, Barbara; Dello Russo, Claudio; Colussi, Claudia; Rosati, Jessica; Pallaoro, Michele; Spallotta, Francesco; Rotili, Dante; Valente, Sergio; Ragone, Gianluca; Martelli, Fabio; Biglioli, Paolo; Steinkuhler, Christian; Gallinari, Paola; Mai, Antonello; Capogrossi, Maurizio C; Gaetano, Carlo

    2008-01-04

    Nitric oxide (NO) modulates important endothelial cell (EC) functions and gene expression by a molecular mechanism which is still poorly characterized. Here we show that in human umbilical vein ECs (HUVECs) NO inhibited serum-induced histone acetylation and enhanced histone deacetylase (HDAC) activity. By immunofluorescence and Western blot analyses it was found that NO induced class II HDAC4 and 5 nuclear shuttling and that class II HDACs selective inhibitor MC1568 rescued serum-dependent histone acetylation above control level in NO-treated HUVECs. In contrast, class I HDACs inhibitor MS27-275 had no effect, indicating a specific role for class II HDACs in NO-dependent histone deacetylation. In addition, it was found that NO ability to induce HDAC4 and HDAC5 nuclear shuttling involved the activation of the protein phosphatase 2A (PP2A). In fact, HDAC4 nuclear translocation was impaired in ECs expressing small-t antigen and exposed to NO. Finally, in cells engineered to express a HDAC4-Flag fusion protein, NO induced the formation of a macromolecular complex including HDAC4, HDAC3, HDAC5, and an active PP2A. The present results show that NO-dependent PP2A activation plays a key role in class II HDACs nuclear translocation.

  16. Radiation effects in concrete for nuclear power plants, Part II: Perspective from micromechanical modeling

    DOE PAGES

    Le Pape, Yann; Field, Kevin G.; Remec, Igor

    2014-11-15

    The need to understand and characterize the effects of neutron irradiation on concrete has become urgent because of the possible extension of service life of many nuclear power generating stations. Current knowledge is primarily based on a collection of data obtained in test reactors. These results are inherently difficult to interpret because materials and testing conditions are inconsistent. A micromechanical approach based on the Hashin composite sphere model is presented to derive a first-order separation of the effects of radiation on cement paste and aggregate, and, also, on their interaction. Although the scarcity of available data limits the validation ofmore » the model, it appears that, without negating a possible gamma-ray induced effect, the neutron-induced damage and swelling of aggregate plays a predominant role on the overall concrete expansion and the damage of the cement paste. Finally, the radiation-induced volumetric expansion (RIVE) effects can also be aided by temperature elevation and shrinkage in the cement paste.« less

  17. Design of sample carrier for neutron irradiation facility at TRIGA MARK II nuclear reactor

    NASA Astrophysics Data System (ADS)

    Abdullah, Y.; Hamid, N. A.; Mansor, M. A.; Ahmad, M. H. A. R. M.; Yusof, M. R.; Yazid, H.; Mohamed, A. A.

    2013-06-01

    The objective of this work is to design a sample carrier for neutron irradiation experiment at beam ports of research nuclear reactor, the Reaktor TRIGA PUSPATI (RTP). The sample carrier was designed so that irradiation experiment can be performed safely by researchers. This development will resolve the transferring of sample issues faced by the researchers at the facility when performing neutron irradiation studies. The function of sample carrier is to ensure the sample for the irradiation process can be transferred into and out from the beam port of the reactor safely and effectively. The design model used was House of Quality Method (HOQ) which is usually used for developing specifications for product and develop numerical target to work towards and determining how well we can meet up to the needs. The chosen sample carrier (product) consists of cylindrical casing shape with hydraulic cylinders transportation method. The sample placing can be done manually, locomotion was by wheel while shielding used was made of boron materials. The sample carrier design can shield thermal neutron during irradiation of sample so that only low fluencies fast neutron irradiates the sample.

  18. Parallel Algorithms and Software for Nuclear, Energy, and Environmental Applications. Part II: Multiphysics Software

    SciTech Connect

    Derek Gaston; Luanjing Guo; Glen Hansen; Hai Huang; Richard Johnson; Dana Knoll; Chris Newman; Hyeong Kae Park; Robert Podgorney; Michael Tonks; Richard Williamson

    2012-09-01

    This paper is the second part of a two part sequence on multiphysics algorithms and software. The first [1] focused on the algorithms; this part treats the multiphysics software framework and applications based on it. Tight coupling is typically designed into the analysis application at inception, as such an application is strongly tied to a composite nonlinear solver that arrives at the final solution by treating all equations simultaneously. The application must also take care to minimize both time and space error between the physics, particularly if more than one mesh representation is needed in the solution process. This paper presents an application framework that was specifically designed to support tightly coupled multiphysics analysis. The Multiphysics Object Oriented Simulation Environment (MOOSE) is based on the Jacobian-free Newton-Krylov (JFNK) method combined with physics-based preconditioning to provide the underlying mathematical structure for applications. The report concludes with the presentation of a host of nuclear, energy, and environmental applications that demonstrate the efficacy of the approach and the utility of a well-designed multiphysics framework.

  19. TRIGA Mark II nuclear reactor facility. Final report, 1 July 1980--30 June 1995

    SciTech Connect

    Ryan, B.C.

    1997-05-01

    This report is a final culmination of activities funded through the Department of Energy`s (DOE) University Reactor Sharing Program, Grant DE-FG02-80ER10273, during the period 1 July 1980 through 30 June 1995. Progress reports have been periodically issued to the DOE, namely the Reactor Facility Annual Reports C00-2082/2219-7 through C00-2082/10723-21, which are contained as an appendix to this report. Due to the extent of time covered by this grant, summary tables are presented. Table 1 lists the fiscal year financial obligations of the grant. As listed in the original grant proposals, the DOE grant financed 70% of project costs, namely the total amount spent of these projects minus materials costs and technical support. Thus the bulk of funds was spent directly on reactor operations. With the exception of a few years, spending was in excess of the grant amount. As shown in Tables 2 and 3, the Reactor Sharing grant funded a immense number of research projects in nuclear engineering, geology, animal science, chemistry, anthropology, veterinary medicine, and many other fields. A list of these users is provided. Out of the average 3000 visitors per year, some groups participated in classes involving the reactor such as Boy Scout Merit Badge classes, teacher`s workshops, and summer internships. A large number of these projects met the requirements for the Reactor Sharing grant, but were funded by the University instead.

  20. Dynamics of asymmetric binary glass formers. II. Results from nuclear magnetic resonance spectroscopy

    SciTech Connect

    Bock, D.; Kahlau, R.; Pötzschner, B.; Körber, T.; Wagner, E.; Rössler, E. A.

    2014-03-07

    Various {sup 2}H and {sup 31}P nuclear magnetic resonance (NMR) spectroscopy techniques are applied to probe the component dynamics of the binary glass former tripropyl phosphate (TPP)/polystyrene-d{sub 3} (PS) over the full concentration range. The results are quantitatively compared to those of a dielectric spectroscopy (DS) study on the same system previously published [R. Kahlau, D. Bock, B. Schmidtke, and E. A. Rössler, J. Chem. Phys. 140, 044509 (2014)]. While the PS dynamics does not significantly change in the mixtures compared to that of neat PS, two fractions of TPP molecules are identified, one joining the glass transition of PS in the mixture (α{sub 1}-process), the second reorienting isotropically (α{sub 2}-process) even in the rigid matrix of PS, although at low concentration resembling a secondary process regarding its manifestation in the DS spectra. Pronounced dynamical heterogeneities are found for the TPP α{sub 2}-process, showing up in extremely stretched, quasi-logarithmic stimulated echo decays. While the time window of NMR is insufficient for recording the full correlation functions, DS results, covering a larger dynamical range, provide a satisfactory interpolation of the NMR data. Two-dimensional {sup 31}P NMR spectra prove exchange within the broadly distributed α{sub 2}-process. As demonstrated by {sup 2}H NMR, the PS matrix reflects the faster α{sub 2}-process of TPP by performing a spatially highly hindered motion on the same timescale.

  1. Nuclear Waste Management under Approaching Disaster: A Comparison of Decommissioning Strategies for the German Repository Asse II.

    PubMed

    Ilg, Patrick; Gabbert, Silke; Weikard, Hans-Peter

    2016-06-14

    This article compares different strategies for handling low- and medium-level nuclear waste buried in a retired potassium mine in Germany (Asse II) that faces significant risk of uncontrollable brine intrusion and, hence, long-term groundwater contamination. We survey the policy process that has resulted in the identification of three possible so-called decommissioning options: complete backfilling, relocation of the waste to deeper levels in the mine, and retrieval. The selection of a decommissioning strategy must compare expected investment costs with expected social damage costs (economic, environmental, and health damage costs) caused by flooding and subsequent groundwater contamination. We apply a cost minimization approach that accounts for the uncertainty regarding the stability of the rock formation and the risk of an uncontrollable brine intrusion. Since economic and health impacts stretch out into the far future, we examine the impact of different discounting methods and rates. Due to parameter uncertainty, we conduct a sensitivity analysis concerning key assumptions. We find that retrieval, the currently preferred option by policymakers, has the lowest expected social damage costs for low discount rates. However, this advantage is overcompensated by higher expected investment costs. Considering all costs, backfilling is the best option for all discounting scenarios considered.

  2. Analysis of heavy metals from water, sediment, and tissues of Labeo angra (Hamilton, 1822), from an Ox-box lake- an wetland site from Assam, India.

    PubMed

    Das, Suchismita; Choudhury, Shamim Sultana

    2016-01-01

    The aim of this study was to assess the regional impacts of heavy metals (Mn, Fe, Mg, Ca, Cu, Zn, Cd, Cr, Pb and Ni) on water, sediment and a native, teleost fish species, Labeo angra, inhabiting a flood plain wetland of Barak River in Assam, India. Heavy metal concentrations in the water, sediments and fish were measured; bioaccumulation factor, metal pollution index as well as condition indices were calculated, to assess the pollution load and health status of the fish. Multivariate statistical analysis was used on wetland water and sediment heavy metals to ascertain the possible sources and seasonal variations of the pollutants. Results showed that most heavy metals in the wetland water and sediments exceeded the water (drinking and irrigation) and sediment quality guidelines, respectively. Seasonal variations were observed for geogenic heavy metals, Mn, Fe, Mg and Ca while no seasonal variations were observed for anthropogenic heavy metals, Cu, Cd, Cr, Pb and Ni. Multivariate statistical analysis showed that there was strong correlation between geogenic and anthropogenic heavy metals in water and sediment, both originating from the common anthropogenic sources. Accumulation of most of the metals in all the tissues was above the safe limits as recommended by the Food and Agriculture Organization. High bioaccumulation factors and metal pollution index for these metals in the different tissues revealed that metals were extensively bio-accumulated and bioconcentrated. Condition indices in fish from the wetland suggested metabolic abnormalities.

  3. ASPECTS OF THE ECOLOGY OF PHLEBOTOMINES (Diptera: Psychodidae: Phlebotominae) IN AN AREA OF CUTANEOUS LEISHMANIASIS OCCURRENCE, MUNICIPALITY OF ANGRA DOS REIS, COAST OF RIO DE JANEIRO STATE, BRAZIL

    PubMed Central

    de Aguiar, Gustavo Marins; de Azevedo, Alfredo Carlos Rodrigues; de Medeiros, Wagner Muniz; Alves, João Ricardo Carreira; Rendeiro, Vanessa

    2014-01-01

    Over a complete two-year period, phlebotomine specimens were caught in an area of cutaneous leishmaniasis occurrence in the municipality of Angra dos Reis. A manual suction tube was used to catch phlebotomines on house walls, and also light traps in domestic and peridomestic settings and in the forest. This yielded 14,170 specimens of 13 species: two in the genus Brumptomyia and eleven in the genus Lutzomyia. L. intermedia predominantly in domestic and peridomestic settings, with little presence in the forest, with the same trend being found in relation to L. migonei, thus proving that these species have adapted to the human environment. L. fischeri appeared to be eclectic regarding location, but was seen to be proportionally more endophilic. L. intermedia and L. migonei were more numerous in peridomestic settings, throughout the year, while L. fischeri was more numerous in domestic settings except in March, April, May and September. From the prevalence of L. intermedia, its proven anthropophily and findings of this species naturally infected with Leishmania (Viannia) braziliensis, it can be incriminated as the main vector for this agent of cutaneous leishmaniasis in the study area, especially in the peridomestic environment. L. fischeri may be a coadjuvant in carrying the parasite. PMID:24626417

  4. FINESSE: study of the issues, experiments and facilities for fusion nuclear technology research and development. Interim report. Volume II

    SciTech Connect

    Abdou, M.

    1984-10-01

    The Nuclear Fusion Issues chapter contains a comprehensive list of engineering issues for fusion reactor nuclear components. The list explicitly defines the uncertainties associated with the engineering option of a fusion reactor and addresses the potential consequences resulting from each issue. The next chapter identifies the fusion nuclear technology testing needs up to the engineering demonstration stage. (MOW)

  5. Accumulation of radioactive corrosion products on steel surfaces of VVER-type nuclear reactors. II. 60Co

    NASA Astrophysics Data System (ADS)

    Varga, Kálmán; Hirschberg, Gábor; Németh, Zoltán; Myburg, Gerrit; Schunk, János; Tilky, Péter

    2001-10-01

    In the case of intact fuel claddings, the predominant source of radioactivity in the primary circuits of water-cooled nuclear reactors is the activation of corrosion products in the core. The most important corrosion product radionuclides in the primary coolant of pressurized water reactors (PWRs) are 60Co, 58Co, 51Cr, 54Mn, 59Fe (as well as 110mAg in some Soviet-made VVER-type reactor). The second part of this series is focused on the complex studies of the formation and build-up of 60Co-containing species on an austenitic stainless steel type 08X18H10T (GOST 5632-61) and magnetite-covered carbon steel often to be used in Soviet-planned VVERs. The kinetics and mechanism of the cobalt accumulation were studied by a combination (coupling) of an in situ radiotracer method and voltammetry in a model solution of the primary circuit coolant. In addition, independent techniques such as X-ray photoelectron spectroscopic (XPS) and ICP-OES are also used to analyze the chemical state of Co species in the passive layer formed on stainless steel as well as the chemical composition of model solution. The experimental results have revealed that: (i) The passive behavior of the austenitic stainless steel at open-circuit conditions, the slightly alkaline pH and the reducing water chemistry can be considered to be optimal to minimize the 60Co contamination. (ii) The highly potential dependent deposition of various Co-oxides at E>1.10 V (vs. RHE) offers a unique possibility to elaborate a novel electrochemical method for the decrease or removal of cobalt traces from borate-containing coolants contaminated with 60Co and/or 58Co radionuclides.

  6. Photobilirubin II.

    PubMed Central

    Bonnett, R; Buckley, D G; Hamzetash, D; Hawkes, G E; Ioannou, S; Stoll, M S

    1984-01-01

    An improved preparation of photobilirubin II in ammoniacal methanol is described. Evidence is presented which distinguishes between the two structures proposed earlier for photobilirubin II in favour of the cycloheptadienyl structure. Nuclear-Overhauser-enhancement measurements with bilirubin IX alpha and photobilirubin II in dimethyl sulphoxide are complicated by the occurrence of negative and zero effects. The partition coefficient of photobilirubin II between chloroform and phosphate buffer (pH 7.4) is 0.67. PMID:6743241

  7. Nanocellulose/nanobentonite composite anchored with multi-carboxyl functional groups as an adsorbent for the effective removal of Cobalt(II) from nuclear industry wastewater samples.

    PubMed

    Anirudhan, T S; Deepa, J R; Christa, J

    2016-04-01

    A novel adsorbent, poly(itaconic acid/methacrylic acid)-grafted-nanocellulose/nanobentonite composite [P(IA/MAA)-g-NC/NB] with multi carboxyl functional groups for the effective removal of Cobalt(II) [Co(II)] from aqueous solutions. The adsorbent was characterized using FTIR, XRD, SEM-EDS, AFM and potentiometric titrations before and after adsorption of Co(II) ions. FTIR spectra revealed that Co(II) adsorption on to the polymer may be due to the involvement of COOH groups. The surface morphological changes were observed by the SEM images. The pH was optimized as 6.0. An adsorbent dose of 2.0g/L found to be sufficient for the complete removal of Co(II) from 100mg/L at room temperature. Pseudo-first-order and pseudo-second-order models were tested to describe kinetic data and adsorption of Co(II) follows pseudo-second-order model. The equilibrium attained at 120min. Isotherm studies were conducted and data were analyzed using Langmuir, Freundlich and Sips isotherm models and best fit was Sips model. Thermodynamic study confirmed endothermic and physical nature of adsorption of the Co(II) onto the adsorbent. Desorption experiments were done with 0.1MHCl proved that without significant loss in performance adsorbent could be reused for six cycles. The practical efficacy and effectiveness of the adsorbent were tested using nuclear industrial wastewater. A double stage batch adsorption system was designed from the adsorption isotherm data of Co(II) by constructing operating lines.

  8. Proceedings of the Fiber Optics in the Nuclear Environment Symposium 25-27 March 1980. Volume II. Radiation Physics,

    DTIC Science & Technology

    1980-04-30

    emphasis on systems for transmitting nuclear device diagnostic data during, or shortly after, a nuclear explosion . This interest has required...Corp. A1rN: YCPT D. Bartel ATN: T. Neighbors ATTN: YCD E. Brininstool ATfI: ¥CD R. Spray Bell Telephone Labs ATTN: YCP H. Staubs ATTN: J. Fleming

  9. Public perception of the nuclear area in Brazil

    SciTech Connect

    Imeida, R.A. de

    2013-07-01

    In Brazil electricity production is proving increasingly important, the Brazilian government has recently launched the National Energy Plan, PNE-2030 which aims, among other objectives, to conclude construction of the Angra 3 plant and to deploy new nuclear power plants in the Northeast region. The Brazilian government wants to assess how the public has perceived its energy policy and what the public thinks about the nuclear issue. A public opinion survey was performed and sampling resulted in 127 respondents who were stratified by gender, age and educational level. The survey results show that although most respondents have post-graduate degrees, 64.6% are not aware of, or had never heard of PNE-2030. While 72 respondents consider nuclear energy as an alternative source of clean energy, 84 respondents did not know where the next Brazilian nuclear power plant will be built. The nuclear regulator, CNEN, is seen by 45.7% of respondents as the body that has most credibility to talk about the safety of nuclear power plants and the media most used to obtain information about the nuclear area were newspapers and discussion forums, with 52 and 50 votes respectively. These results prove the need to implement communication plans with clear and concise goals for different segments of society, since the degree of understanding differs within each segment.

  10. Heterogeneity of nuclear estrogen-binding sites in the rat uterus: a simple method for the quantitation of type I and type II sites by (3H)estradiol exchange

    SciTech Connect

    Markaverich, B.M.; Williams, M.; Upchurch, S.; Clark, J.H.

    1981-07-01

    Estrogen administration to mature-ovariectomized rats causes the activation or stimulation of secondary nuclear estrogen-binding sites (type II) in the uterus which can interfere with estrogen receptor (type I) measurement. Earlier reports from our laboratory have shown that quantitation of type I sites in the presence of the type II site is very difficult and can only be achieved by graphic analysis of saturation curves which employ a wide range (0.4-40 NM) of (/sup 3/H)estradiol concentrations in nuclear exchange assay. The studies presented in this manuscript describe simple methods which can be used to separately quantitate both nuclear estrogen-binding sites using a single concentration of (/sup 3/H)estradiol. Since the nuclear type II site does not bind (/sup 3/H)estradiol in the presence of reducing agent, type I sites can be easily quantitated by incubating nuclei (37 C for 30 min) in Tris-EDTA buffer containing 0.1-1.00 mM dithiothreitol using a single saturating concentration of (/sup 3/H)estradiol. Conversely, a single concentration of (/sup 3/H)estradiol (40-80 nM) can be used to quantitate the nuclear type II site by incubating nuclei in Tris-EDTA buffer under conditions (4 C for 60 min) which do not measure occupied nuclear estrogen receptor. Therefore, by using the appropriate buffer system, type I and type II sites can be easily separated in mixed binding systems. In addition, we also demonstrate that Nafoxidine does not bind to the nuclear type II site. Therefore, it can be used as a competitive inhibitor of (/sup 3/H)estradiol binding to type I sites and permit the measurement of type II sites without interference from type I sites. These techniques should be applicable to autoradiographic or fluorescence studies which cannot discriminate between steroid binding to these two classes of nuclear estrogen-binding sites.

  11. Nukes II: the nuclear power industry wants another chance. This time, it promises to do things right

    SciTech Connect

    De Young, H.G.

    1985-03-01

    Anticipating a comback for nuclear power, the nuclear industry points to the need for reliable supplies of electricity to provide over 35% of US energy requirements. The industry faces both technical and institutional problems, in contrast to the mature industry of other countries, and promises to improve its performance in safety design and efficiency. Pointing to design advances, robotics, computerized simulation and other techniques, the industry feels that regulation will be more reasonable and costs will be reduced. Economic solutions include building smaller plants and using modular construction. The biggest uncertainty, however, is whether the public will buy either the need for additional capacity or nuclear power to fill that need.

  12. Environmental resources and potential impacts for a nuclear energy center near Green River, Utah. Volume II. Maps

    SciTech Connect

    Not Available

    1981-01-01

    Maps are included for baseline studies for siting a nuclear energy park. Surface waters, ground water, water resources, forests, plant flora, land use, land ownership and mineral deposits are detailed. (PSB)

  13. A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans

    PubMed Central

    Ahn, Jeong H.; Rechsteiner, Andreas; Strome, Susan; Kelly, William G.

    2016-01-01

    The elongation phase of transcription by RNA Polymerase II (Pol II) involves numerous events that are tightly coordinated, including RNA processing, histone modification, and chromatin remodeling. RNA splicing factors are associated with elongating Pol II, and the interdependent coupling of splicing and elongation has been documented in several systems. Here we identify a conserved, multi-domain cyclophilin family member, SIG-7, as an essential factor for both normal transcription elongation and co-transcriptional splicing. In embryos depleted for SIG-7, RNA levels for over a thousand zygotically expressed genes are substantially reduced, Pol II becomes significantly reduced at the 3’ end of genes, marks of transcription elongation are reduced, and unspliced mRNAs accumulate. Our findings suggest that SIG-7 plays a central role in both Pol II elongation and co-transcriptional splicing and may provide an important link for their coordination and regulation. PMID:27541139

  14. Members of the nuclear factor 1 family and hepatocyte nuclear factor 4 bind to overlapping sequences of the L-II element on the rat pyruvate kinase L gene promoter and regulate its expression.

    PubMed

    Yamada, K; Tanaka, T; Noguchi, T

    1997-06-15

    The L-II element (-149 to -126 bp) in the enhancer unit of the rat pyruvate kinase L (PKL) gene is required for cell-type-specific transcription and induction by carbohydrates. This element was found to bind multiple nuclear proteins with different heat stabilities. A heat-labile factor was shown to be hepatocyte nuclear factor (HNF) 4 by the electrophoretic mobility-shift assay (EMSA) using various competitor DNAs and anti-HNF4 serum. A heat-stable factor was purified from rat liver nuclear extract and was resolved as two protein bands migrating at about 33 kDa on SDS/polyacrylamide gels. Peptide sequence analysis revealed that these proteins were nuclear factor (NF) 1-L and NF1/Red1. The heat-stable factor was also identified as a member of the NF1 family by using various competitor DNAs and anti-NF1 serum in an EMSA. In addition, we found that a factor bound to the accessory site of the rat S14 gene, which is necessary for carbohydrate responsiveness of this gene, was also a member of the NF1 family, raising the possibility that the NF1 family is involved in the carbohydrate regulation of gene transcription by interactions with other proteins. The NF1 family members and HNF4 interacted with overlapping sequences of the L-II element, wherein the 5' half-site was more critical for NF1 binding, and the 3' site was more important for HNF4 binding. Co-transfection of a vector expressing either NF1-L or NF1/Red1 repressed the transcription of the PKL enhancer unit-chloramphenicol acetyltransferase (CAT) fusion gene in HepG2 cells, whereas co-transfection of a vector expressing HNF4 activated the transcription of the same reporter gene. Furthermore NF1 family members antagonized the effect of HNF4 on PKL enhancer unit-CAT fusion gene expression when both expression plasmids were co-transfected. We conclude that NF1 family members and HNF4 regulate transcription of the PKL gene in an opposing manner by binding overlapping sequences of the L-II element.

  15. Development and Validation of Methodology to Model Flow in Ventilation Systems Commonly Found in Nuclear Facilities - Phase II

    SciTech Connect

    Strons, Philip; Bailey, James L.; Davis, John; Grudzinski, James; Hlotke, John

    2016-03-01

    In this report we present the results of the Phase II analysis and testing of the flow patterns encountered in the Alpha Gamma Hot Cell Facility (AGHCF), as well as the results from an opportunity to expand upon field test work from Phase I by the use of a Class IIIb laser. The addition to the Phase I work is covered before proceeding to the results of the Phase II work, followed by a summary of findings.

  16. ATMS_Phase_II: a standalone code for counting non-overlapping high-density nuclear tracks

    NASA Astrophysics Data System (ADS)

    Khayat, Omid

    2014-02-01

    In this paper we focus on counting and density measurements of non-overlapping high-density nuclear track images. This paper is a continuum of another paper of the author introducing ATMS software which has been particularly developed for overlapping nuclear tracks. Here, as the second phase of the ATMS software, a hybrid algorithm is presented for counting the tracks according to user parameter initialization, template inserting and correlation estimation to initially detect nuclear track candidates, then to evaluate geometrical and contextual features of track candidates and finally a decision-making process according to the user's sensitivity considerations. The presented hybrid algorithm is verified and validated by a database containing 100 randomly selected Alpha track images captured from the surface of CR-39 polycarbonate detectors irradiated by environmental Alpha particles emitted from Rn-222 near a copper mine around Anarak city.

  17. Survey II of Public and Leadership Attitudes Toward Nuclear Power Development in the United States. Study No. 2628.

    ERIC Educational Resources Information Center

    Harris (Louis) and Associates, Inc., New York, NY.

    This publication details a national survey done by Louis Harris and Associates, similar to one done in 1975, to assess attitudes toward nuclear power in the United States. The survey consisted of three parts. The first part was in-person, door-to-door interviews with 1,597 randomly selected households nationwide. The second part was 309…

  18. Cd(II) complexes with different nuclearity and dimensionality based on 3-hydrazino-4-amino-1,2,4-triazole

    SciTech Connect

    Xu, Cai-Xia; Zhang, Jian-Guo Yin, Xin; Jin, Xin; Li, Tong; Zhang, Tong-Lai; Zhou, Zun-Ning

    2015-03-15

    A series of zero- to two-dimensional Cd(II) coordination compounds have been synthesized by the reaction of Cd(II) salts and 3-hydrazino-4-amino-1,2,4-triazole di-hydrochloride (HATr·2HCl). [CdCl{sub 2}(HATr){sub 2}] (1) and [Cd{sub 2}Cl{sub 4}(HATr){sub 2}(H{sub 2}O){sub 2}] (2) have discrete mononuclear and binuclear structures, respectively. [Cd(HATr){sub 2}(ClO{sub 4}){sub 2}]{sub n} (3) presents polymeric 1-D chain and [Cd{sub 2}(NO{sub 3}){sub 2}Cl{sub 2}(HATr){sub 2}]{sub n} (4) shows 2-D frameworks. All Cd(II) ions exhibit distorted octahedral configurations in 1–3, whilst both hexa and heptacoordinated Cd(II) are formed in 4. The HATr ligands adopt chelating coordinated mode in 1, while tri-dentate bridging–chelating mode in 2–4. The chloride ion is a mono-coordinated ligand in 1 and 2, but it bridges two adjacent metal ions in 4. Furthermore, thermal behaviors have been investigated and the results reveal that all complexes have good thermal stability. The impact sensitivity test indicates that complex 3 is sensitive to impact stimuli. - Graphical abstract: Four Cd(II) complexes based on 3-hydrazino-4-amino-1,2,4-triazole ligands exhibit diverse structures from mononuclear to 2D networks. - Highlights: • Cd(II) complexes containing 3-hydrazino-4-amino-1,2,4-triazole ligands. • Mononuclear, binuclear, 1-D and 2-D structures. • Good thermal stability. • Thermal decomposition kinetics.

  19. Cobalt(II) chloride adducts with acetonitrile, propan-2-ol and tetrahydrofuran: considerations on nuclearity, reactivity and synthetic applications.

    PubMed

    Stinghen, Danilo; Rüdiger, André Luis; Giese, Siddhartha O K; Nunes, Giovana G; Soares, Jaísa F; Hughes, David L

    2017-02-01

    High-spin cobalt(II) complexes are considered useful building blocks for the synthesis of single-molecule magnets (SMM) because of their intrinsic magnetic anisotropy. In this work, three new cobalt(II) chloride adducts with labile ligands have been synthesized from anhydrous CoCl2, to be subsequently employed as starting materials for heterobimetallic compounds. The products were characterized by elemental, spectroscopic (EPR and FT-IR) and single-crystal X-ray diffraction analyses. trans-Tetrakis(acetonitrile-κN)bis(tetrahydrofuran-κO)cobalt(II) bis[(acetonitrile-κN)trichloridocobaltate(II)], [Co(C2H3N)4(C4H8O)2][CoCl3(C2H3N)]2, (1), comprises mononuclear ions and contains both acetonitrile and tetrahydrofuran (thf) ligands, The coordination polymer catena-poly[[tetrakis(propan-2-ol-κO)cobalt(II)]-μ-chlorido-[dichloridocobalt(II)]-μ-chlorido], [Co2Cl4(C3H8O)4], (2'), was prepared by direct reaction between anhydrous CoCl2 and propan-2-ol in an attempt to rationalize the formation of the CoCl2-alcohol adduct (2), probably CoCl2(HO(i)Pr)m. The binuclear complex di-μ-chlorido-1:2κ(4)Cl:Cl-dichlorido-2κ(2)Cl-tetrakis(tetrahydrofuran-1κO)dicobalt(II), [Co2Cl4(C4H8O)4], (3), was obtained from (2) after recrystallization from tetrahydrofuran. All three products present cobalt(II) centres in both octahedral and tetrahedral environments, the former usually less distorted than the latter, regardless of the nature of the neutral ligand. Product (2') is stabilized by an intramolecular hydrogen-bond network that appears to favour a trans arrangement of the chloride ligands in the octahedral moiety; this differs from the cis disposition found in (3). The expected easy displacement of the bound solvent molecules from the metal coordination sphere makes the three compounds good candidates for suitable starting materials in a number of synthetic applications.

  20. Launch Vehicle Fire Accident Preliminary Analysis of a Liquid-Metal Cooled Thermionic Nuclear Reactor: TOPAZ-II

    NASA Astrophysics Data System (ADS)

    Hu, G.; Zhao, S.; Ruan, K.

    2012-01-01

    In this paper, launch vehicle propellant fire accident analysis of TOPAZ-II reactor has been done by a thermionic reactor core analytic code-TATRHG(A) developed by author. When a rocket explodes on a launch pad, its payload-TOPAZ-II can be subjected to a severe thermal environment from the resulting fireball. The extreme temperatures associated with propellant fires can create a destructive environment in or near the fireball. Different kind of propellants - liquid propellant and solid propellant which will lead to different fire temperature are considered. Preliminary analysis shows that the solid propellant fires can melt the whole toxic beryllium radial reflector.

  1. CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription.

    PubMed Central

    Suñé, C; Hayashi, T; Liu, Y; Lane, W S; Young, R A; Garcia-Blanco, M A

    1997-01-01

    Maximal human immunodeficiency virus type 1 (HIV-1) gene expression requires specific cellular factors in addition to the virus-encoded trans-activator protein Tat and the RNA element TAR. We developed a functional assay, based on transcriptional activation in vitro, to identify these cellular factors. Here, we describe the purification and molecular cloning of CA150, a nuclear protein that is associated with the human RNA polymerase II holoenzyme and is involved in Tat-dependent HIV-1 transcriptional activation. The sequence of CA150 contains an extensive glutamine- and alanine-rich repeat that is found in transcriptional modulators such as GAL11 and SSN6 in Saccharomyces cerevisiae and Zeste in Drosophila melanogaster. Immunodepletion of CA150 abolished Tat trans activation in vitro. Moreover, overexpression of a mutant CA150 protein specifically and dramatically decreased Tat-mediated activation of the HIV-1 promoter in vivo, strongly suggesting a role for CA150 in HIV-1 gene regulation. Immunoprecipitation experiments demonstrated that both CA150 and Tat associate with the RNA polymerase II holoenzyme. Furthermore, we found that functional Tat associates with the holoenzyme whereas activation-deficient Tat mutants do not. Thus, we propose that Tat action is transduced via an RNA polymerase II holoenzyme that contains CA150. PMID:9315662

  2. Mono-nuclear copper complexes mimicking the intermediates for the binuclear copper center of the subunit II of cytochrome oxidase: a peptide based approach.

    PubMed

    Dutta Gupta, Dwaipayan; Usharani, Dandamudi; Mazumdar, Shyamalava

    2016-11-28

    Three stable copper complexes of peptides derived from the copper ion binding loop of the subunit II of cytochrome c oxidase have been prepared and characterized by various spectroscopic techniques. These stable copper complexes of peptides were found to exhibit cysteine, histidine and/or methionine ligation, which has predominant σ-contribution in the Cys-Cu charge transfer. The copper(ii) peptide complexes showed type-2 EPR spectra, which is uncommon in copper-cysteinate complexes. UV-visible spectra, Raman and EPR results support a tetragonal structure of the coordination geometry around the copper ion. The copper complex of the 9-amino acid peptide suggested the formation of a 'red' copper center while the copper complexes of the 12- and 11-amino acid peptides showed the formation of a 'green' copper center. The results provide insights on the first stable models of the copper complexes formed in the peptide scaffold that mimic the mono-nuclear copper bound protein intermediates proposed during the formation of the binuclear Cu2S2 core of the enzyme. These three copper complexes of peptides derived from the metal ion binding loop of the CuA center of the subunit II of cytochrome c oxidase showed novel spectroscopic properties which have not so far been reported in any stable small complex.

  3. Applications of nuclear physics.

    PubMed

    Hayes, A C

    2017-02-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applications of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.

  4. Applications of nuclear physics

    DOE PAGES

    Hayes-Sterbenz, Anna Catherine

    2017-01-10

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applicationsmore » of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Lastly, each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.« less

  5. Applications of nuclear physics

    NASA Astrophysics Data System (ADS)

    Hayes, A. C.

    2017-02-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applications of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.

  6. Di- and tetra-nuclear copper(II), nickel(II), and cobalt(II) complexes of four bis-tetradentate triazole-based ligands: synthesis, structure, and magnetic properties.

    PubMed

    Olguín, Juan; Kalisz, Marguerite; Clérac, Rodolphe; Brooker, Sally

    2012-05-07

    Four bis-tetradentate N(4)-substituted-3,5-{bis[bis-N-(2-pyridinemethyl)]aminomethyl}-4H-1,2,4-triazole ligands, L(Tz1)-L(Tz4), differing only in the triazole N(4) substituent R (where R is amino, pyrrolyl, phenyl, or 4-tertbutylphenyl, respectively) have been synthesized, characterized, and reacted with M(II)(BF(4))(2)·6H(2)O (M(II) = Cu, Ni or Co) and Co(SCN)(2). Experiments using all 16 possible combinations of metal salt and L(TzR) were carried out: 14 pure complexes were obtained, 11 of which are dinuclear, while the other three are tetranuclear. The dinuclear complexes include two copper(II) complexes, [Cu(II)(2)(L(Tz2))(H(2)O)(4)](BF(4))(4) (2), [Cu(II)(2)(L(Tz4))(BF(4))(2)](BF(4))(2) (4); two nickel(II) complexes, [Ni(II)(2)(L(Tz1))(H(2)O)(3)(CH(3)CN)](BF(4))(4)·0.5(CH(3)CN) (5) and [Ni(II)(2)(L(Tz4))(H(2)O)(4)](BF(4))(4)·H(2)O (8); and seven cobalt(II) complexes, [Co(II)(2)(L(Tz1))(μ-BF(4))](BF(4))(3)·H(2)O (9), [Co(II)(2)(L(Tz2))(μ-BF(4))](BF(4))(3)·2H(2)O (10), [Co(II)(2)(L(Tz3))(H(2)O)(2)](BF(4))(4) (11), [Co(II)(2)(L(Tz4))(μ-BF(4))](BF(4))(3)·3H(2)O (12), [Co(II)(2)(L(Tz1))(SCN)(4)]·3H(2)O (13), [Co(II)(2)(L(Tz2))(SCN)(4)]·2H(2)O (14), and [Co(II)(2)(L(Tz3))(SCN)(4)]·H(2)O (15). The tetranuclear complexes are [Cu(II)(4)(L(Tz1))(2)(H(2)O)(2)(BF(4))(2)](BF(4))(6) (1), [Cu(II)(4)(L(Tz3))(2)(H(2)O)(2)(μ-F)(2)](BF(4))(6)·0.5H(2)O (3), and [Ni(II)(4)(L(Tz3))(2)(H(2)O)(4)(μ-F(2))](BF(4))(6)·6.5H(2)O (7). Single crystal X-ray structure determinations revealed different solvent content from that found by microanalysis of the bulk sample after drying under a vacuum and confirmed that 5', 8', 9', 11', 12', and 15' are dinuclear while 1' and 7' are tetranuclear. As expected, magnetic measurements showed that weak antiferromagnetic intracomplex interactions are present in 1, 2, 4, 7, and 8, stabilizing a singlet spin ground state. All seven of the dinuclear cobalt(II) complexes, 9-15, have similar magnetic behavior and remain in the [HS-HS] state

  7. Quantitative prediction of nuclear-spin-diffusion-limited coherence times of molecular quantum bits based on copper(ii).

    PubMed

    Lenz, S; Bader, K; Bamberger, H; van Slageren, J

    2017-04-06

    We have investigated the electron spin dynamics in a series of copper(ii) β-diketonate complexes both in frozen solutions and doped solids. Double digit microsecond coherence times were found at low temperatures. We report quantitative simulations of the coherence decays solely based on the crystal structure of the doped solids.

  8. Nuclear Technology. Course 32: Nondestructive Examination (NDE) Techniques II. Module 32-5, Fundamentals of Eddy Current Testing.

    ERIC Educational Resources Information Center

    Espy, John

    This fifth in a series of six modules for a course titled Nondestructive Examination (NDE) Techniques II describes the fundamental concepts applicable to eddy current testing in general. The module follows a typical format that includes the following sections: (1) introduction, (2) module prerequisites, (3) objectives, (4) notes to…

  9. Nuclear Technology. Course 32: Nondestructive Examination (NDE) Techniques II. Module 32-6, Operation of Eddy Current Test Equipment.

    ERIC Educational Resources Information Center

    Espy, John; Selleck, Ben

    This sixth in a series of six modules for a course titled Nondestructive Examination (NDE) Techniques II details eddy current examination of steam generator tubing. The module follows a typical format that includes the following sections: (1) introduction, (2) module prerequisites, (3) objectives, (4) notes to instructor/student, (5) subject…

  10. Nuclear Technology. Course 32: Nondestructive Examination (NDE) Techniques II. Module 32-2, Operation of Ultrasonic Test Equipment.

    ERIC Educational Resources Information Center

    Espy, John

    This second in a series of six modules for a course titled Nondestructive Examination (NDE) II describes specific ultrasonic test techniques and calibration principles. The module follows a typical format that includes the following sections: (1) introduction, (2) module prerequisites, (3) objectives, (4) notes to instructor/student, (5) subject…

  11. Nuclear Technology. Course 32: Nondestructive Examination (NDE) Techniques II. Module 32-1, Fundamentals of Ultrasonic Testing.

    ERIC Educational Resources Information Center

    Spaulding, Bruce

    This first in a series of six modules for a course titled Nondestructive Examination (NDE) Techniques II introduces the student/trainee to the basic behavior of ultrasound, describes ultrasonic test equipment, and outlines the principal methods of ultrasonic testing. The module follows a typical format that includes the following sections: (1)…

  12. The Politics of Forgetting: Otto Hahn and the German Nuclear-Fission Project in World War II

    NASA Astrophysics Data System (ADS)

    Sime, Ruth Lewin

    2012-03-01

    As the co-discoverer of nuclear fission and director of the Kaiser Wilhelm Institute for Chemistry, Otto Hahn (1879-1968) took part in Germany`s nuclear-fission project throughout the Second World War. I outline Hahn's efforts to mobilize his institute for military-related research; his inclusion in high-level scientific structures of the military and the state; and his institute's research programs in neutron physics, isotope separation, transuranium elements, and fission products, all of potential military importance for a bomb or a reactor and almost all of it secret. These activities are contrasted with Hahn's deliberate misrepresentations after the war, when he claimed that his wartime work had been nothing but "purely scientific" fundamental research that was openly published and of no military relevance.

  13. Medical countermeasures for unwanted CBRN exposures: part II radiological and nuclear threats with review of recent countermeasure patents

    PubMed Central

    Singh, Vijay K.; Romaine, Patricia L.P.; Newman, Victoria L.; Seed, Thomas M.

    2016-01-01

    ABSTRACT Introduction: The global threat of a chemical, biological, radiological, or nuclear (CBRN) disaster is an important priority for all government agencies involved in domestic security and public health preparedness. Radiological/nuclear (RN) attacks or accidents have become a larger focus of the United States Food and Drug administration (US FDA) over time because of their increased likeliness. Clinical signs and symptoms of a developing acute radiation syndrome (ARS) are grouped into three sub-syndromes named for the dominant organ system affected, namely the hematopoietic (H-ARS), gastrointestinal (GI-ARS), and neurovascular systems. The availability of safe and effective countermeasures against radiological/nuclear threats currently represents a significant unmet medical need. Areas covered: This article reviews the development of RN threat medical countermeasures and highlights those specific countermeasures that have been recently patented and approved following the FDA Animal Rule. Patents for such agents from 2015 have been presented. Expert opinion: Two granulocyte colony-stimulating factor (G-CSF)-based radiation countermeasures (Neupogen® (Amgen, Thousand Oaks, CA) and Neulasta® (Amgen, Thousand Oaks, CA)) have recently been approved by the FDA for treatment of H-ARS and both these agents are radiomitigators, used after radiation exposure. To date, there are no FDA-approved radioprotectors for ARS. PMID:27610458

  14. Specification and verification of nuclear-power-plant training-simulator response characteristics. Part II. Conclusions and recommendations

    SciTech Connect

    Haas, P M; Selby, D L; Kerlin, T W; Felkins, L

    1982-05-01

    The nuclear industry should adopt and NRC regulatory and research actions should support the systems approach to training as a structured framework for development and validation of personnel training systems. Potential exists for improving the ability to assess simulator fidelity. Systems Identification Technology offers a potential framework for model validation. Installation of the data collection/recording equipment required by NUREG-0696 could provide a vastly improved source of data for simulator fidelity assessment. The NRC needs to continue its post-TMI actions to involve itself more rigorously and more formally in the entire process of NPP personnel training system development. However, this involvement should be a participative one with industry. The existing similator standards and guidelines should be reorganized to support the use of systems approach to training. The standards should require and support a holistic approach to training system development that recognizes simulators and simulator training as only parts of the complete training program and full-scope, high-fidelity, site-specific simulators as only one useful training device. Some recommendations for adapting the SAT/ISD process to the nuclear industry are: The formation of an NRC/industry planning/coordination group, a program planning study to develop a programmatic plan, development of a user's guide and NRC/industry workshops to establish common terminology and practice, and a pilot study applying the adopted SAT/ISD methodology to an actual nuclear industry training program.

  15. Measurements of miniature ionization chamber currents in the JSI TRIGA Mark II reactor demonstrate the importance of the delayed contribution to the photon field in nuclear reactors

    NASA Astrophysics Data System (ADS)

    Radulović, Vladimir; Fourmentel, Damien; Barbot, Loïc; Villard, Jean-François; Kaiba, Tanja; Gašper, Žerovnik; Snoj, Luka

    2015-12-01

    The characterization of experimental locations of a research nuclear reactor implies the determination of neutron and photon flux levels within, with the best achievable accuracy. In nuclear reactors, photon fluxes are commonly calculated by Monte Carlo simulations but rarely measured on-line. In this context, experiments were conducted with a miniature gas ionization chamber (MIC) based on miniature fission chamber mechanical parts, recently developed by the CEA (French Atomic Energy and Alternative Energies Commission) irradiated in the core of the Jožef Stefan Institute TRIGA Mark II reactor in Ljubljana, Slovenia. The aim of the study was to compare the measured MIC currents with calculated currents based on simulations with the MCNP6 code. A discrepancy of around 50% was observed between the measured and the calculated currents; in the latter taking into consideration only the prompt photon field. Further experimental measurements of MIC currents following reactor SCRAMs (reactor shutdown with rapid insertions of control rods) provide evidence that over 30% of the total measured signal is due to the delayed photon field, originating from fission and activation products, which are untreated in the calculations. In the comparison between the measured and calculated values, these findings imply an overall discrepancy of less than 20% of the total signal which is still unexplained.

  16. Ca2+/calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection.

    PubMed

    Maubach, Gunter; Sokolova, Olga; Wolfien, Markus; Rothkötter, Hermann-Josef; Naumann, Michael

    2013-09-15

    Helicobacter pylori, a class I carcinogen, induces a proinflammatory response by activating the transcription factor nuclear factor-kappa B (NF-κB) in gastric epithelial cells. This inflammatory condition could lead to chronic gastritis, which is epidemiologically and biologically linked to the development of gastric cancer. So far, there exists no clear knowledge on how H. pylori induces the NF-κB-mediated inflammatory response. In our study, we investigated the role of Ca(2+) /calmodulin-dependent kinase II (CAMKII), calmodulin, protein kinases C (PKCs) and the CARMA3-Bcl10-MALT1 (CBM) complex in conjunction with H. pylori-induced activation of NF-κB via the inhibitor of nuclear factor-kappa B kinase (IKK) complex. We use specific inhibitors and/or RNA interference to assess the contribution of these components. Our results show that CAMKII and calmodulin contribute to IKK complex activation and thus to the induction of NF-κB in response to H. pylori infection, but not in response to TNF-α. Thus, our findings are specific for H. pylori infected cells. Neither the PKCs α, δ, θ, nor the CBM complex itself is involved in the activation of NF-κB by H. pylori. The contribution of CAMKII and calmodulin, but not PKCs/CBM to the induction of an inflammatory response by H. pylori infection augment the understanding of the molecular mechanism involved and provide potential new disease markers for the diagnosis of gastric inflammatory diseases including gastric cancer.

  17. Npa3/ScGpn1 carboxy-terminal tail is dispensable for cell viability and RNA polymerase II nuclear targeting but critical for microtubule stability and function.

    PubMed

    Guerrero-Serrano, Gehenna; Castanedo, Leonardo; Cristóbal-Mondragón, Gema R; Montalvo-Arredondo, Javier; Riego-Ruíz, Lina; DeLuna, Alexander; De Las Peñas, Alejandro; Castaño, Irene; Calera, Mónica R; Sánchez-Olea, Roberto

    2017-03-01

    Genetic deletion of the essential GTPase Gpn1 or replacement of the endogenous gene by partial loss of function mutants in yeast is associated with multiple cellular phenotypes, including in all cases a marked cytoplasmic retention of RNA polymerase II (RNAPII). Global inhibition of RNAPII-mediated transcription due to malfunction of Gpn1 precludes the identification and study of other cellular function(s) for this GTPase. In contrast to the single Gpn protein present in Archaea, eukaryotic Gpn1 possesses an extension of approximately 100 amino acids at the C-terminal end of the GTPase domain. To determine the importance of this C-terminal extension in Saccharomyces cerevisiae Gpn1, we generated yeast strains expressing either C-terminal truncated (gpn1ΔC) or full-length ScGpn1. We found that ScGpn1ΔC was retained in the cell nucleus, an event physiologically relevant as gpn1ΔC cells contained a higher nuclear fraction of the RNAPII CTD phosphatase Rtr1. gpn1ΔC cells displayed an increased size, a delay in mitosis exit, and an increased sensitivity to the microtubule polymerization inhibitor benomyl at the cell proliferation level and two cellular events that depend on microtubule function: RNAPII nuclear targeting and vacuole integrity. These phenotypes were not caused by inhibition of RNAPII, as in gpn1ΔC cells RNAPII nuclear targeting and transcriptional activity were unaffected. These data, combined with our description here of a genetic interaction between GPN1 and BIK1, a microtubule plus-end tracking protein with a mitotic function, strongly suggest that the ScGpn1 C-terminal tail plays a critical role in microtubule dynamics and mitotic progression in an RNAPII-independent manner.

  18. Gamma irradiation-induced modifications of polymers found in nuclear waste embedding processes Part II: The ion-exchange resin

    NASA Astrophysics Data System (ADS)

    Debré, O.; Nsouli, B.; Thomas, J.-P.; Stevenson, I.; Colombini, D.; Romero, M.-A.

    1997-08-01

    Ion exchange resins (IERs) saturated in cesium and borate ions are well representative of low and medium activity nuclear waste to be embedded in an epoxy resin/amine hardener, such a conditioning procedure being under qualification. In order to test these materials in realistic conditions they are externally irradiated (air and water), in mixed beds saturated in fixed ions (cesium and borate) and water. Irradiation effects are evidenced with the HSF-SIMS technique by the variation of the emission characteristic of both the fixed ions, the chemical structure of the IERs and their interrelationship, both from the analysis of the solid material and of the residual or rinsing water. It appears that the fixed ions can be released in surrounding water as a consequence of radiation-induced resin fragments solubility.

  19. Primary and secondary relaxation process in plastically crystalline cyanocyclohexane studied by 2H nuclear magnetic resonance. II. Quantitative analysis

    NASA Astrophysics Data System (ADS)

    Micko, B.; Kruk, D.; Rössler, E. A.

    2013-02-01

    We analyze the results of our previously reported 2H nuclear magnetic resonance (NMR) experiments in the plastically crystalline (PC) phase of cyanocyclohexane (Part I of this work) to study the fast secondary relaxation (or β-process) in detail. Both, the occurrence of an additional minimum in the spin-lattice relaxation T1 and the pronounced effects arising in the solid-echo spectrum above the glass transition temperature Tg = 134 K, allow for a direct determination of the restricting geometry of the β-process in terms of the "wobbling-in-a-cone" model. Whereas at temperatures below Tg the reorientation is confined to rather small solid angles (below 10°), the spatial restriction decreases strongly with temperature above Tg, i.e., the distribution of cone angles shifts continuously towards higher values. The β-process in the PC phase of cyanocyclohexane proceeds via the same mechanism as found in structural glass formers. This is substantiated by demonstrating the very similar behavior (for T < Tg) of spin-lattice relaxation, stimulated echo decays, and spectral parameters when plotted as a function of ⟨log τβ⟩ (taken from dielectric spectroscopy). We do, however, not observe a clear-cut relation between the relaxation strength of the β-process observed by NMR (calculated within the wobbling-in-a-cone model) and dielectric spectroscopy.

  20. An analysis of thermionic space nuclear reactor power system: II. Merits of using safety drums for backup control

    SciTech Connect

    El-Genk, M.S.; Huimin Xue )

    1993-01-10

    An analysis is performed to investigate the merits of using the TOPAZ-II safety drums for a backup control to prevent a reactivity excursion, stabilize the reactor, and achieve steady-state power operation, following a severe hypothetical reactivity initiated accident (RIA). Such an RIA is assumed to occur during the system start-up in orbit due to a malfunction of the drive mechanism of the control drums, causing the nine drums to accidentally rotate the full 180[degree] outward. Results show that an immediate, inward rotation of the three safety drums to an angle of 80[degree] will shutdown the reactor, however, a delay time of 10 s will not only prevents a reactivity excursion, but also enables operating the reactor at a steady-state thermal power of about 33.3 kW (0.9 kW per TFE). Conversely, when the immediate rotation of the safety drums is to a larger angle of 100[degree], a steady-state operation at about 37 kW can be achieved, but a delay of 10 s causes a reactivity excursion and overheating of the TFEs. It is therefor concluded that, should the drive mechanism be modified to enable rotating the safety drums for TOPAZ-II reactor at variable speeds of and below 22.5[degree]/s, the three safety drums could be used successfully for a backup control, following an RIA. However, since the reactivity worth of the three safety drums is only $2.0, the maximum steady-state electric power achievable for the system is limited to approximately 0.25 kW, at which the fission power is about 37 kW and the emitter temperature is approximaely 1500 K. To alleviate such a limitation and enable operation at nominal design conditions (fission power of about 107 kW or a system's total electric power of 5.6 kW), the reactivity worth of the safety drums would have to be increased by at least $0.24.

  1. Low energy electron and nuclear recoil thresholds in the DRIFT-II negative ion TPC for dark matter searches

    NASA Astrophysics Data System (ADS)

    Burgos, S.; Daw, E.; Forbes, J.; Ghag, C.; Gold, M.; Hagemann, C.; Kudryavtsev, V. A.; Lawson, T. B.; Loomba, D.; Majewski, P.; Muna, D.; Murphy, A. St. J.; Paling, S. M.; Petkov, A.; Plank, S. J. S.; Robinson, M.; Sanghi, N.; Snowden-Ifft, D. P.; Spooner, N. J. C.; Turk, J.; Tziaferi, E.

    2009-04-01

    Understanding the ability to measure and discriminate particle events at the lowest possible energy is an essential requirement in developing new experiments to search for weakly interacting massive particle (WIMP) dark matter. In this paper we detail an assessment of the potential sensitivity below 10 keV in the 1 m3 DRIFT-II directionally sensitive, low pressure, negative ion time projection chamber (NITPC), based on event-by-event track reconstruction and calorimetry in the multiwire proportional chamber (MWPC) readout. By application of a digital smoothing polynomial it is shown that the detector is sensitive to sulfur and carbon recoils down to 2.9 and 1.9 keV respectively, and 1.2 keV for electron induced events. The energy sensitivity is demonstrated through the 5.9 keV gamma spectrum of 55Fe, where the energy resolution is sufficient to identify the escape peak. The effect of a lower energy sensitivity on the WIMP exclusion limit is demonstrated. In addition to recoil direction reconstruction for WIMP searches this sensitivity suggests new prospects for applications also in KK axion searches.

  2. Galaxy gas as obscurer - II. Separating the galaxy-scale and nuclear obscurers of active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Buchner, Johannes; Bauer, Franz E.

    2017-03-01

    The 'torus' obscurer of active galactic nuclei (AGN) is poorly understood in terms of its density, sub-structure and physical mechanisms. Large X-ray surveys provide model boundary constraints, for both Compton-thin and Compton-thick levels of obscuration, as obscured fractions are mean covering factors fcov. However, a major remaining uncertainty is host-galaxy obscuration. In Paper I, we discovered a relation of {NH} ∝ M_{star }^{1/3} for the obscuration of galaxy-scale gas. Here, we apply this observational relation to the AGN population, and find that galaxy-scale gas is responsible for a luminosity-independent fraction of Compton-thin AGN, but does not produce Compton-thick columns. With the host-galaxy obscuration understood, we present a model of the remaining nuclear obscurer, which is consistent with a range of observations. Our radiation-lifted torus model consists of a Compton-thick component (fcov ∼ 35 per cent) and a Compton-thin component (fcov ∼ 40 per cent), which depends on both black hole mass and luminosity. This provides a useful summary of observational constraints for torus modellers who attempt to reproduce this behaviour. It can also be employed as a sub-grid recipe in cosmological simulations that do not resolve the torus. We also investigate host-galaxy X-ray obscuration inside cosmological, hydrodynamic simulations (Evolution and Assembly of Galaxies and their Environment; Illustris). The obscuration from ray-traced galaxy gas can agree with observations, but is highly sensitive to the chosen feedback assumptions.

  3. Identification of polyproline II regions derived from the proline-rich nuclear receptor coactivators PNRC and PNRC2: new insights for ERα coactivator interactions.

    PubMed

    Byrne, C; Miclet, E; Broutin, I; Gallo, D; Pelekanou, V; Kampa, M; Castanas, E; Leclercq, G; Jacquot, Y

    2013-10-01

    Protein-protein interactions are crucial for signal transductions required for cell differentiation and proliferation. Their modulation is therefore key to the development of therapeutic alternatives, particularly in the context of cancer. According to literature data, the polyproline-rich nuclear receptor coactivators PNRC and PNRC2 interact with estrogen receptor (ERα) through their PxxP SH3-binding motifs. In a search to identify the molecular features governing this interaction, we explored using electronic circular dichroism (ECD) spectroscopy and molecular dynamics (MD) calculations, the capacity of a range of putative biologically active peptides derived from these proteins and containing this PxxP motif(s) to form polyproline II (PPII) domains. An additional more exhaustive structural study on a lead PPII peptide was also performed using 2D nuclear magnetic resonance (NMR) spectroscopy. With the exception of one of all the investigated peptides (PNRC-D), binding assays failed to detect any affinity for Grb2 SH3 domains, suggesting that PPII motifs issued from Grb2 antagonists have a binding mode distinct from those derived from Grb2 agonists. Instead, the peptides revealed a competitive binding ability against a synthetic peptide (ERα17p) with a putative PPII-cognate domain located within a coregulator recruitment region of ERα (AF-2 site). Our work, which constitutes the first structure-related interaction study concerning PNRC and PNRC2, supports not only the existence of PxxP-induced PPII sequences in these coregulators, but also confirms the presence of a PPII recognition site in the AF-2 of the steroid receptor ERα, a region important for transcription regulation.

  4. Nuclear membrane: nuclear envelope PORosity in fission yeast meiosis.

    PubMed

    Sazer, Shelley

    2010-11-09

    The fission yeast Schizosaccharomyces pombe undergoes closed mitosis but 'virtual nuclear envelope breakdown' at anaphase of meiosis II, in which the nuclear envelope is structurally closed but functionally open.

  5. Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex

    PubMed Central

    Thakker, Suhani; Purushothaman, Pravinkumar; Gupta, Namrata; Challa, Shanthan; Cai, Qiliang

    2015-01-01

    ABSTRACT Major histocompatibility complex class II (MHC-II) molecules play a central role in adaptive antiviral immunity by presenting viral peptides to CD4+ T cells. Due to their key role in adaptive immunity, many viruses, including Kaposi's sarcoma-associated herpesvirus (KSHV), have evolved multiple strategies to inhibit the MHC-II antigen presentation pathway. The expression of MHC-II, which is controlled mainly at the level of transcription, is strictly dependent upon the binding of the class II transactivator (CIITA) to the highly conserved promoters of all MHC-II genes. The recruitment of CIITA to MHC-II promoters requires its direct interactions with a preassembled MHC-II enhanceosome consisting of cyclic AMP response element-binding protein (CREB) and nuclear factor Y (NF-Y) complex and regulatory factor X (RFX) complex proteins. Here, we show that KSHV-encoded latency-associated nuclear antigen (LANA) disrupts the association of CIITA with the MHC-II enhanceosome by binding to the components of the RFX complex. Our data show that LANA is capable of binding to all three components of the RFX complex, RFX-associated protein (RFXAP), RFX5, and RFX-associated ankyrin-containing protein (RFXANK), in vivo but binds more strongly with the RFXAP component in in vitro binding assays. Levels of MHC-II proteins were significantly reduced in KSHV-infected as well as LANA-expressing B cells. Additionally, the expression of LANA in a luciferase promoter reporter assay showed reduced HLA-DRA promoter activity in a dose-dependent manner. Chromatin immunoprecipitation assays showed that LANA binds to the MHC-II promoter along with RFX proteins and that the overexpression of LANA disrupts the association of CIITA with the MHC-II promoter. These assays led to the conclusion that the interaction of LANA with RFX proteins interferes with the recruitment of CIITA to MHC-II promoters, resulting in an inhibition of MHC-II gene expression. Thus, the data presented here identify

  6. Alternative energy source II; Proceedings of the Second Miami International Conference, Miami Beach, Fla., December 10-13, 1979. Volume 6 - Nuclear energy

    NASA Astrophysics Data System (ADS)

    Veziroglu, T. N.

    This volume examines conventional nuclear energy, breeder reactors, and thermonuclear energy. The particular papers presented consider current developments in nuclear breeder technology, fusion-driven fissile fuel breeder systems, and the fusion fission hybrid reactor. The implications of nuclear energy utilization in the Phillipines and the internationally safeguarded atomic fuel exchanger center for the Asian-Pacific basin are also discussed.

  7. Studies on the sorption and desorption characteristics of Zn(II) on the surface soils of nuclear power plant sites in India using a radiotracer technique.

    PubMed

    Dahiya, Sudhir; Shanwal, A V; Hegde, A G

    2005-09-01

    Zinc adsorption was studied in the soils of three nuclear power plant sites of India. 65Zn was used as a radiotracer to study the sorption characteristics of Zn(II). The sorption of zinc was determined at 25 and 45 degrees C at pH 7.8+/-0.2 in the solution of 0.01 M Ca(NO3)2 as supporting electrolyte. The sorption data was tested both in Freundlich and Langmuir isotherms and could be described satisfactorily. The effect of organic matter and other physico-chemical properties on the uptake of zinc was also studied in all the soil samples. The results showed that the cation exchange capacity, organic matter, pH and clay content were the main contributors to zinc sorption in these soils. The adsorption maximum was found to be higher in the soil on Kakarpara Atomic Power Plant sites soils having high organic matter and clay content. The zinc supply parameters of the soils are also discussed. In the desorption studies, the sequential extraction of the adsorbed zinc from soils showed that the diethylene triamine penta acetic acid extracted maximum amount of adsorbed zinc than CaCl2 and Mg(NO3)2. The zinc sorption on the soil and amount of zinc retention after extractants desorption shows a positively correlation with vermiculite and smectite mineral content present in the clay fraction of the soil. The amount desorbed by strong base (NaOH) and demineralised water was almost negligible from soils of all the sites, whereas the desorption by strong acid (HNO3) was 75-96% of the adsorbed zinc.

  8. The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts.

    PubMed

    Castaño, E; Gross, P; Wang, Z; Roeder, R G; Oelgeschläger, T

    2000-06-20

    Activation of class II gene transcription may involve alleviation of transcription repression as well as stimulation of the assembly and function of the general RNA polymerase (RNAP) II transcription machinery. Here, we investigated whether activator-reversible transcription repression by NC2 (Dr1/DRAP1) contributes to maximum induction levels in unfractionated HeLa nuclear extracts. Surprisingly, we found that depletion of NC2 does not significantly affect basal transcription, but dramatically reduces activated transcription. Immunoblot analyses revealed that the loss of activator function coincides with selective removal of the C-terminal domain (CTD)-hyperphosphorylated RNAP IIO along with NC2. Coimmunoprecipitation experiments with purified factors confirmed that NC2 interacts with RNAP IIO, but not with the unphosphorylated or hypophosphorylated RNAP IIA or CTD-less RNAP IIB forms. Finally, we demonstrate that, in contrast to previously published observations in cell-free systems reconstituted with purified factors, only the CTD-phosphorylated form of RNAP II can mediate activator function in the context of unfractionated HeLa nuclear extracts. These findings reveal an unexpected link between NC2 and transcription activation and suggest that regulation of RNAP II transcription through reversible CTD phosphorylation might be more complex than previously proposed.

  9. Deployment of a three-dimensional array of Micro-Pocket Fission Detector triads (MPFD3) for real-time, in-core neutron flux measurements in the Kansas State University TRIGA Mark-II Nuclear Reactor

    NASA Astrophysics Data System (ADS)

    Ohmes, Martin Francis

    A Micro-Pocket Fission Detector (MPFD) is a miniaturized type of fission chamber developed for use inside a nuclear reactor. Their unique design allows them to be located between or even inside fuel pins while being built from materials which give them an operational lifetime comparable to or exceeding the life of the fuel. While other types of neutron detectors have been made for use inside a nuclear reactor, the MPFD is the first neutron detector which can survive sustained use inside a nuclear reactor while providing a real-time measurement of the neutron flux. This dissertation covers the deployment of MPFDs as a large three-dimensional array inside the Kansas State University TRIGA Mark-II Nuclear Reactor for real-time neutron flux measurements. This entails advancements in the design, construction, and packaging of the Micro-Pocket Fission Detector Triads with incorporated Thermocouple, or MPFD3-T. Specialized electronics and software also had to be designed and built in order to make a functional system capable of collecting real-time data from up to 60 MPFD3-Ts, or 180 individual MPFDs and 60 thermocouples. Design of the electronics required the development of detailed simulations and analysis for determining the theoretical response of the detectors and determination of their size. The results of this research shows that MPFDs can operate for extended times inside a nuclear reactor and can be utilized toward the use as distributed neutron detector arrays for advanced reactor control systems and power mapping. These functions are critical for continued gains in efficiency of nuclear power reactors while also improving safety through relatively inexpensive redundancy.

  10. Fn14 is regulated via the RhoA pathway and mediates nuclear factor-kappaB activation by Angiotensin II

    PubMed Central

    Li, Zhengwei; Shen, Zhida; Du, Lailing; He, Jialin; Chen, Shengyu; Zhang, Jiefang; Luan, Yi; Fu, Guosheng

    2016-01-01

    Angiotesin II (Ang II) plays an important role in cardiac remodeling. Fibroblast growth factor inducible-14 (Fn14) is the smallest member of the tumor necrosis factor superfamily of receptors. Currently, little is known about the functional role of Fn14 in the heart. Chiefly, we observe the up-regulation of extracellular matrix in in vivo model. We therefore assess the expression and regulation of Fn14 in cardiomyocytes and in vivo models induced by Ang II. In order to study the regulation of Fn14, cardiac remodeling was established in rats and neonatal cardiomyocytes were used in in vitro model. As well, Ang II is able to strongly induce Fn14 expression in in vivo and in vitro models. Fn14 is mediated via RhoA pathways, since siRNA against RhoA prevented the expression of Fn14 in cardiomyocytes. Pretreatment of cardiomyoctes with siRNA against NF-κB and IκBα also decreased Fn14 expression induced by Ang II. We here describe for the first time Ang II regulation of Fn14 in in vivo and in vitro models via RhoA, NF-κB and NF-κB driven gene signaling pathway. In conclusion, Fn14 may be important in regulating the process of cardiac remodeling induced by Ang II. PMID:28078010

  11. The LLNL Heavy Element Facility -- Facility Management, Authorization Basis, and Readiness Assessment Lessons Learned in the Heavy Element Facility (B251) Transition from Category II Nuclear Facility to Radiological Facility

    SciTech Connect

    Mitchell, M; Anderson, B; Brown, E; Gray, L

    2006-04-10

    This paper presents Facility Management, Readiness Assessment, and Authorization Basis experience gained and lessons learned during the Heavy Element Facility Risk Reduction Program (RRP). The RRP was tasked with removing contaminated glove boxes, radioactive inventory, and contaminated ventilation systems from the Heavy Element Facility (B251) at Lawrence Livermore National Laboratory (LLNL). The RRP was successful in its goal in April 2005 with the successful downgrade of B251 from a Category II Nuclear Facility to a Radiological Facility. The expertise gained and the lessons learned during the planning and conduct of the RRP included development of unique approaches in work planning/work control (''Expect the unexpected and confirm the expected'') and facility management. These approaches minimized worker dose and resulted in significant safety improvements and operational efficiencies. These lessons learned can help similar operational and management activities at other sites, including facilities restarting operations or new facility startup. B251 was constructed at LLNL to provide research areas for conducting experiments in radiochemistry using transuranic elements. Activities at B251 once included the preparation of tracer sets associated with the underground testing of nuclear devices and basic research devoted to a better understanding of the chemical and nuclear behavior of the transuranic elements. Due to the age of the facility, even with preventative maintenance, facility safety and experimental systems were deteriorating. A variety of seismic standards were used in the facility design and construction, which encompassed eight building increments constructed over a period of 26 years. The cost to bring the facility into compliance with the current seismic and other requirements was prohibitive, and simply maintaining B251 as a Category II nuclear facility posed serious cost considerations under a changing regulatory environment. Considering the high

  12. HFNET-A Computer Program to Calculate Nuclear Effects on HF/VHF Communications Systems. Volume II. User’s Guide.

    DTIC Science & Technology

    1979-11-30

    Identify by block number) HFNET Code User’s Guide HF Communications Systems Nuclear Effects Computer Simulation 20, AiPr*t"rIAC r ntae ,eo .e std newaswy a...fds dify. by block minu b r) The HFNET computer code is a simulation for estimating the performance of HF communications systems in a nuclear weapon...and/or 22Dist Special 2.9 $PLCALC KEYWORD 28 2.10 $ DEBUG KEYWORD 30 2.11 $RUN KEYWORD 33 3 HFNET OUTPUT 35 3.1 GENERAL 35 3.2 SIMULATION START OUTPUT

  13. Transcriptional up-regulation of nitric oxide synthase II by nuclear factor-kappaB at rostral ventrolateral medulla in a rat mevinphos intoxication model of brain stem death.

    PubMed

    Chan, Julie Y H; Wu, Carol H Y; Tsai, Ching-Yi; Cheng, Hsiao-Lei; Dai, Kuang-Yu; Chan, Samuel H H; Chang, Alice Y W

    2007-06-15

    As the origin of a 'life-and-death' signal that reflects central cardiovascular regulatory failure during brain stem death, the rostral ventrolateral medulla (RVLM) is a suitable neural substrate for mechanistic delineation of this vital phenomenon. Using a clinically relevant animal model that employed the organophosphate pesticide mevinphos (Mev) as the experimental insult, we evaluated the hypothesis that transcriptional up-regulation of nitric oxide synthase I or II (NOS I or II) gene expression by nuclear factor-kappaB (NF-kappaB) on activation of muscarinic receptors in the RVLM underlies brain stem death. In Sprague-Dawley rats maintained under propofol anaesthesia, co-microinjection of muscarinic M2R (methoctramine) or M4R (tropicamide), but not M1R (pirenzepine) or M3R (4-diphenylacetoxy-N-dimethylpiperidinium) antagonist significantly reduced the enhanced NOS I-protein kinase G signalling ('pro-life' phase) or augmented NOS II-peroxynitrite cascade ('pro-death' phase) in ventrolateral medulla, blunted the biphasic increase and decrease in baroreceptor reflex-mediated sympathetic vasomotor tone that reflect the transition from life to death, and diminished the elevated DNA binding activity or nucleus-bound translocation of NF-kappaB in RVLM neurons induced by microinjection of Mev into the bilateral RVLM. However, NF-kappaB inhibitors (diethyldithiocarbamate or pyrrolidine dithiocarbamate) or double-stranded kappaB decoy DNA preferentially antagonized the augmented NOS II-peroxynitrite cascade and the associated cardiovascular depression exhibited during the 'pro-death' phase. We conclude that transcriptional up-regulation of NOS II gene expression by activation of NF-kappaB on selective stimulation of muscarinic M2 or M4 subtype receptors in the RVLM underlies the elicited cardiovascular depression during the 'pro-death' phase in our Mev intoxication model of brain stem death.

  14. Dynamic nuclear polarisation via the integrated solid effect II: experiments on naphthalene-h8 doped with pentacene-d14

    NASA Astrophysics Data System (ADS)

    Eichhorn, T. R.; van den Brandt, B.; Hautle, P.; Henstra, A.; Wenckebach, W. Th.

    2014-07-01

    In dynamic nuclear polarisation (DNP), also called hyperpolarisation, a small amount of unpaired electron spins is added to the sample containing the nuclear spins, and the polarisation of these unpaired electron spins is transferred to the nuclear spins by means of a microwave field. Traditional DNP polarises the electron spin of stable paramagnetic centres by cooling down to low temperature and applying a strong magnetic field. Then weak continuous wave microwave fields are used to induce the polarisation transfer. Complicated cryogenic equipment and strong magnets can be avoided using short-lived photo-excited triplet states that are strongly aligned in the optical excitation process. However, a much faster transfer of the electron spin polarisation is needed and pulsed DNP methods like nuclear orientation via electron spin locking (NOVEL) and the integrated solid effect (ISE) are used. To describe the polarisation transfer with the strong microwave fields in NOVEL and ISE, the usual perturbation methods cannot be used anymore. In the previous paper, we presented a theoretical approach to calculate the polarisation transfer in ISE. In the present paper, the theory is applied to the system naphthalene-h8 doped with pentacene-d14 yielding the photo-excited triplet states and compared with experimental results.

  15. Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-κB activation-induced nitric oxide synthase II expression.

    PubMed

    Chang, Chiung-Chih; Chen, Shang-Der; Lin, Tsu-Kung; Chang, Wen-Neng; Liou, Chia-Wei; Chang, Alice Y W; Chan, Samuel H H; Chuang, Yao-Chung

    2014-02-01

    Status epilepticus induces subcellular changes that may eventually lead to neuronal cell death in the hippocampus. Based on an animal model of status epilepticus, our laboratory showed previously that sustained hippocampal seizure activity activates nuclear factor-κB (NF-κB) and upregulates nitric oxide synthase (NOS) II gene expression, leading to apoptotic neuronal cell death in the hippocampus. The present study examined the potential modulatory role of heat shock protein 70 (HSP70) on NF-κB signaling in the hippocampus following experimental status epilepticus. In Sprague-Dawley rats, kainic acid (KA) was microinjected unilaterally into the hippocampal CA3 subfield to induce prolonged bilateral seizure activity. Expression of HSP70 was elevated as early as 1h after the elicitation of sustained seizure activity, followed by a progressive elevation that peaked at 24h. Pretreatment with an antisense oligonucleotide against hsp70 decreased the HSP70 expression, and significantly augmented IκB kinase (IKK) activity and phosphorylation of IκBα, alongside enhanced nuclear translocation and DNA binding activity of NF-κB in the hippocampal CA3 neurons and glial cells. These cellular events were followed by enhanced upregulation of NOS II and peroxynitrite expression 3h after sustained seizure activity that led to an increase of caspase-3 and DNA fragmentation in the hippocampal CA3 neurons 7days after experimental status epilepticus. We concluded that HSP70 protects against apoptotic cell death induced by NF-κB activation and NOS II-peroxynitrite signaling cascade in the hippocampal CA3 and glial cells following experimental status epilepticus via suppression of IKK activity and deactivation of IκBα.

  16. Synthesis, characterization and magnetic studies on mono-, di-, and tri-nuclear Cu(ii) complexes of a new versatile diazine ligand.

    PubMed

    Anwar, Muhammad U; Rawson, Jeremy M; Gavey, Emma L; Pilkington, Melanie; Al-Harrasi, Ahmed; Thompson, Laurence K

    2017-02-14

    The synthesis and coordination chemistry of a new open-chain diazine ligand (L4H2) containing bipyridine, oxime and hydrazone functionalities is reported. Reaction of L4H2 with CuCl2·2H2O affords the mononuclear complex [Cu(L4H2)Cl2] (1) in which the ligand acts as a neutral tridentate N,N',N'' donor, whereas treatment with a large excess of CuCl2·2H2O affords the dinuclear complex [Cu2(L4H)Cl3(CH3OH)(H2O)] (2) in which the ligand is singly-deprotonated at the diazine, offering N,N',N'' and N,N' donor sets to two Cu(ii) ions. Reaction with Cu(NO3)2·3H2O yields the trinuclear complex, [Cu3(L4H)2(CH3OH)4(NO3)4] (3) in which the ligand is again singly deprotonated, but now presents a tetradentate N,N',N'',N'''-donor set to the first Cu(ii) and behaves as an N,O-chelate to a second Cu(ii), with a conformational change from cis to trans at the diazine moiety. When the latter reaction is repeated in the presence of a mild base, a second trinuclear complex is isolated, [Cu3(L4)2(CH3CH2OH)](NO3)2 (4) in which both the diazine and oxime functionalities of the ligand are deprotonated which subsequently bridges all three Cu(ii) ions, acting as an N,N',N'' donor to the first Cu(ii), a N,N' donor to a second Cu(ii) (similar to 2) and as a terminal O-donor to a third Cu(ii) ion. The Cu(ii) ions are linked mutually cis via the two-atom diazine bridge in the case of 2 and 4 and trans in the case of 3. Magnetic studies reveal the presence of weak ferromagnetic interactions in 2 (g = 2.2, J/k = +12.8 K) and strong antiferromagnetic interactions in both 3 and 4 (g = 2.093 J/k = -140 K and g = 2.24 J/k = -300 K respectively).

  17. Nuclear rights - nuclear wrongs

    SciTech Connect

    Paul, E.F.; Miller, F.D.; Paul, J.; Ahrens, J.

    1986-01-01

    This book contains 11 selections. The titles are: Three Ways to Kill Innocent Bystanders: Some Conundrums Concerning the Morality of War; The International Defense of Liberty; Two Concepts of Deterrence; Nuclear Deterrence and Arms Control; Ethical Issues for the 1980s; The Moral Status of Nuclear Deterrent Threats; Optimal Deterrence; Morality and Paradoxical Deterrence; Immoral Risks: A Deontological Critique of Nuclear Deterrence; No War Without Dictatorship, No Peace Without Democracy: Foreign Policy as Domestic Politics; Marxism-Leninism and its Strategic Implications for the United States; Tocqueveille War.

  18. Estimation of conventional C-Hπ (arene), unconventional C-Hπ (chelate) and C-Hπ (thiocyanate) interactions in hetero-nuclear nickel(ii)-cadmium(ii) complexes with a compartmental Schiff base.

    PubMed

    Roy, Sourav; Drew, Michael G B; Bauzá, Antonio; Frontera, Antonio; Chattopadhyay, Shouvik

    2017-04-07

    Three new heteronuclear nickel(ii)/cadmium(ii) complexes, [(SCN)(Cl)Cd(L)Ni(DMF)2] (1), [(SCN)(CH3CO2)Cd(L)Ni(CH3OH)2] (2) and [(SCN)(Cl)Cd(L)Ni(NH2CH2CH2CH2NH2)]n (3) {where H2L = N,N'-bis(3-ethoxy-salicylidene)propane-1,3-diamine is a N2O4 compartmental Schiff base}, have been synthesized and characterized. The structures of the complexes have been confirmed by single crystal X-ray diffraction studies. In each complex, nickel(ii) is placed in the inner N2O2 environment and cadmium(ii) is placed in the outer O4 compartment of the compartmental Schiff base. Furthermore, the importance of unconventional C-Hπ (chelate) interactions in the solid state of both complexes and C-Hπ (thiocyanate) interaction in complex 2 has been described by means of DFT and MEP calculations and characterized using NCI plots. All complexes show photoluminescence at room temperature upon irradiation by ultraviolet light. The lifetimes of excited states are in the range of 2-6 ns.

  19. Acetate/di-2-pyridyl ketone oximate "blend" as a source of high-nuclearity nickel(II) clusters: dependence of the nuclearity on the nature of the inorganic anion present.

    PubMed

    Stamatatos, Theocharis C; Diamantopoulou, Eleanna; Raptopoulou, Catherine P; Psycharis, Vassilis; Escuer, Albert; Perlepes, Spyros P

    2007-04-02

    The use of di-2-pyridyl ketone oxime [(py)2CNOH] in reactions with Ni(O2CMe)2.4H2O, in the presence or absence of extra inorganic anions (N3- and SCN-) has led to Ni4, Ni5, and Ni7 clusters; the magnetic study of the heptanuclear nickel(II) complex reveals an S = 3 ground state.

  20. Health effects model for nuclear power plant accident consequence analysis. Part I. Introduction, integration, and summary. Part II. Scientific basis for health effects models

    SciTech Connect

    Evans, J.S.; Moeller, D.W.; Cooper, D.W.

    1985-07-01

    Analysis of the radiological health effects of nuclear power plant accidents requires models for predicting early health effects, cancers and benign thyroid nodules, and genetic effects. Since the publication of the Reactor Safety Study, additional information on radiological health effects has become available. This report summarizes the efforts of a program designed to provide revised health effects models for nuclear power plant accident consequence modeling. The new models for early effects address four causes of mortality and nine categories of morbidity. The models for early effects are based upon two parameter Weibull functions. They permit evaluation of the influence of dose protraction and address the issue of variation in radiosensitivity among the population. The piecewise-linear dose-response models used in the Reactor Safety Study to predict cancers and thyroid nodules have been replaced by linear and linear-quadratic models. The new models reflect the most recently reported results of the follow-up of the survivors of the bombings of Hiroshima and Nagasaki and permit analysis of both morbidity and mortality. The new models for genetic effects allow prediction of genetic risks in each of the first five generations after an accident and include information on the relative severity of various classes of genetic effects. The uncertainty in modeloling radiological health risks is addressed by providing central, upper, and lower estimates of risks. An approach is outlined for summarizing the health consequences of nuclear power plant accidents. 298 refs., 9 figs., 49 tabs.

  1. Characterization of degraded EBR-II fuel from the ICPP-603 basin: National spent nuclear fuel program, FY 1999 final report

    SciTech Connect

    Pahl, R. G.

    2000-04-17

    Characterization data is reported for sodium bonded Experimental Breeder Reactor II (EBR-II) fuel which had been stored underwater in containers since the late 1970's. Sixteen stainless steel storage containers were retrieved from the ICPP-603 storage pool at the Idaho National Engineering and Environmental Laboratory (INEEL) in Idaho. Ten of the containers had leaked water due to improper sealing. In the container chosen for detailed destructive analysis, the stainless steel cladding on the uranium alloy fuel had ruptured and fuel oxide particulate formed and filled the bottom of the container. Headspace gas analysis determined that greater than 99% hydrogen was present. Cesium-137, which had leached out of the fuel during the aqueous corrosion process, dominated the radionuclide source term of the water. The metallic sodium from the fuel element bond had reacted with the water, forming a caustic solution of NaOH.

  2. I. Excluded Volume Effects in Ising Cluster Distributions and Nuclear Multifragmentation II. Multiple-Chance Effects in α-Particle Evaporation

    SciTech Connect

    Breus, Dimitry Eugene

    2005-05-16

    In Part 1, geometric clusters of the Ising model are studied as possible model clusters for nuclear multifragmentation. These clusters may not be considered as non-interacting (ideal gas) due to excluded volume effect which predominantly is the artifact of the cluster's finite size. Interaction significantly complicates the use of clusters in the analysis of thermodynamic systems. Stillinger's theory is used as a basis for the analysis, which within the RFL (Reiss, Frisch, Lebowitz) fluid-of-spheres approximation produces a prediction for cluster concentrations well obeyed by geometric clusters of the Ising model. If thermodynamic condition of phase coexistence is met, these concentrations can be incorporated into a differential equation procedure of moderate complexity to elucidate the liquid-vapor phase diagram of the system with cluster interaction included. The drawback of increased complexity is outweighted by the reward of greater accuracy of the phase diagram, as it is demonstrated by the Ising model. A novel nuclear-cluster analysis procedure is developed by modifying Fisher's model to contain cluster interaction and employing the differential equation procedure to obtain thermodynamic variables. With this procedure applied to geometric clusters, the guidelines are developed to look for excluded volume effect in nuclear multifragmentation. In part 2, an explanation is offered for the recently observed oscillations in the energy spectra of α-particles emitted from hot compound nuclei. Contrary to what was previously expected, the oscillations are assumed to be caused by the multiple-chance nature of α-evaporation. In a semi-empirical fashion this assumption is successfully confirmed by a technique of two-spectra decomposition which treats experimental α-spectra has having contributions from at least two independent emitters. Building upon the success of the multiple-chance explanation of the oscillations, Moretto's single-chance evaporation theory is

  3. Nuclear Medicine.

    ERIC Educational Resources Information Center

    Badawi, Ramsey D.

    2001-01-01

    Describes the use of nuclear medicine techniques in diagnosis and therapy. Describes instrumentation in diagnostic nuclear medicine and predicts future trends in nuclear medicine imaging technology. (Author/MM)

  4. Operate a Nuclear Power Plant.

    ERIC Educational Resources Information Center

    Frimpter, Bonnie J.; And Others

    1983-01-01

    Describes classroom use of a computer program originally published in Creative Computing magazine. "The Nuclear Power Plant" (runs on Apple II with 48K memory) simulates the operating of a nuclear generating station, requiring students to make decisions as they assume the task of managing the plant. (JN)

  5. Dissociative electron attachment to the H2O molecule. II. Nuclear dynamics on coupled electronic surfaces within the local complex potential model

    NASA Astrophysics Data System (ADS)

    Haxton, Daniel J.; Rescigno, T. N.; McCurdy, C. W.

    2007-01-01

    We report the results of a first-principles study of dissociative electron attachment to H2O . The cross sections were obtained from nuclear dynamics calculations carried out in full dimensionality within the local complex potential model by using the multiconfiguration time-dependent Hartree method. The calculations employ our previously obtained global, complex-valued, potential-energy surfaces for the three ( B12 , A12 , and B22 ) electronic Feshbach resonances involved in this process. These three metastable states of H2O- undergo several degeneracies, and we incorporate both the Renner-Teller coupling between the B12 and A12 states as well as the conical intersection between the A12 and B22 states into our treatment. The nuclear dynamics are inherently multidimensional and involve branching between different final product arrangements as well as extensive excitation of the diatomic fragment. Our results successfully mirror the qualitative features of the major fragment channels observed, but are less successful in reproducing the available results for some of the minor channels. We comment on the applicability of the local complex potential model to such a complicated resonant system.

  6. Dual Species Noble Gas Nuclear Spin Polarizer for a New Search for the Atomic EDM of Xe-129 at FRM-II (Munich Research Reactor)

    NASA Astrophysics Data System (ADS)

    Cohn, Jared; Coulter, Daniel; Frisbie, Dustin; Fromm, Steven; Huneau, Jake; Rabga, Tenzin; Underwood, Walter; Singh, Jaideep; Fierlinger, Peter; Kraegeloh, Eva; Kuchler, Florian; Lins, Tobias; Marino, Mike; Meinel, Jonas; Neissen, Benjamin; Stuiber, Stefan; Fan, Isaac; Kilian, Wolfgang; Knappe-Gruenberg, Silvia; Trahms, Lutz; Chupp, Tim; Degenkolb, Skyler; Sachdeva, Natasha; Gong, Fei; Babcock, Earl; Fierlinger Group Team; Chupp Laboratory Team; Physikalisch-Technische Bundesanstalt Collaboration; Juelich CenterNeutron Science Collaboration

    2015-10-01

    Electric dipole moments are believed to be very sensitive probes of CP violation beyond the Standard Model. A new search for the atomic electric dipole moment of Xe-129 is currently underway at FRM-II in Munich. Our technique takes advantage of a state of the art magnetically shielded room, ultra-sensitive magnetometry using SQUIDs, and control of systematics using a He-3 co-magnetometer. Our goal is an order of magnitude improvement over the previous Xe-129 atomic EDM limit. We will describe the design and construction of a noble gas polarizer using spectrally-narrow diode lasers. Technische Universitaet Muenchen.

  7. Global disturbances of the ionosphere caused by the electric field from the high-altitude nuclear explosion 'Starfish' on July 9, 1962. I, II

    NASA Astrophysics Data System (ADS)

    Tsedilina, E. E.; Shashun'kina, V. M.

    1990-10-01

    The theory of the formation of an artifical radiation belt of high-energy electrons in the magnetosphere is used to examine possible ionospheric effects from the electric field generated by the Starfish nuclear test explosion over Johnston Island on July 9, 1962. A region in the Northern Hemisphere is identified where the explosion led to a drop in electron density in the F-region maximum by about 20 percent and a lowering of the layer by 20-30 km in the course of one hour after the explosion. The F-layer gradually came back to normal in the following hour. It is suggested that, in the initial period after the explosion, this effect was associated with the western electric field, which caused the lowering of the F-layer, as well as with changes in the recombination-diffusion balance in this layer.

  8. Chromosome aberrations induced in human lymphocytes by U-235 fission neutrons: I. Irradiation of human blood samples in the "dry cell" of the TRIGA Mark II nuclear reactor.

    PubMed

    Fajgelj, A; Lakoski, A; Horvat, D; Remec, I; Skrk, J; Stegnar, P

    1991-11-01

    A set-up for irradiation of biological samples in the TRIGA Mark II research reactor in Ljubljana is described. Threshold activation detectors were used for characterisation of the neutron flux, and the accompanying gamma dose was measured by TLDs. Human peripheral blood samples were irradiated "in vitro" and biological effects evaluated according to the unstable chromosomal aberrations induced. Biological effects of two types of cultivation of irradiated blood samples, the first immediately after irradiation and the second after 96 h storage, were studied. A significant difference in the incidence of chromosomal aberrations between these two types of samples was obtained, while our dose-response curve fitting coefficients alpha 1 = (7.71 +/- 0.09) x 10(-2) Gy-1 (immediate cultivation) and alpha 2 = (11.03 +/- 0.08) x 10(-2) Gy-1 (96 h delayed cultivation) are in both cases lower than could be found in the literature.

  9. Plant small nuclear RNAs. II. U6 RNA and a 4.5SI-like RNA are present in plant nuclei.

    PubMed Central

    Kiss, T; Antal, M; Solymosy, F

    1987-01-01

    Two small nuclear RNA species (U6 RNA and a 4.5SI-like RNA) not described so far for plants were detected in broad bean (Vicia faba L.) nuclei. U6 RNA is 98 nucleotides long, contains psi and methylated nucleotides and shows a surprisingly high degree of sequence homology (80%) with its rat counterpart, particularly in the middle part (a 57 nucleotide-long stretch) of the molecule, where it amounts to 98%. The 4.5SI-like RNA, similar in its structure to 4.5SI RNA detected so far only in rodent nuclei, is 94 nucleotides long, contains psi and an unidentified nucleotide and exhibits 52% overall sequence homology with rat 4.5SI RNA. A block of 20 consecutive nucleotides at the 5' end of the molecule is conserved between broad bean 4.5SI-like RNA and rat 4.5SI RNA. The presence of the two RNA polymerase III internal promoter consensus sequences in 4.5SI-like RNA suggests that it is an RNA polymerase III transcript. Images PMID:2434924

  10. Effects of alien and intraspecies cytoplasms on manifestation of nuclear genes for wheat resistance to brown rust: II. Specificity of cytoplasm influence on different Lr genes

    SciTech Connect

    Voluevich, E.A.; Buloichik, A.A.; Palilova, A.N.

    1995-04-01

    Specificity of expression of the major nuclear genes Lr to two brown rust clones in hybrids with the same maternal cytoplasm was analyzed. It was evaluated by a resistant: susceptible ratio in the F{sub 2}. Reciprocal hybrids were obtained from the cross between the progeny of homozygous susceptible plants of the cultivar Penjamo 62 and its alloplasmatic lines carrying cytoplasms of Triticum dicoccoides var. fulvovillosum, Aegilops squarrosa var. typical, Agropyron trichophorum, and isogenic lines of the cultivar Thatcher (Th) with the Lr1, Lr9, Lr15, and Lr19 genes. It was shown that the effect of the Lr1 gene in the cytoplasm of cultivar Thatcher and in eu-, and alloplasmatic forms of Penjamo 62 was less expressed than that of other Lr genes. Cytoplasm of the alloplasmatic line (dicoccoides)-Penjamo 62 was the only exception: in the F{sub 2}, hybrids with Th (Lr1) had a higher yield of resistant forms than those with Th (Lr15). In the hybrid combinations studied, expression and/or transmission of the Lr19 gene was more significant than that of other genes. This gene had no advantages over Lr15 and Lr19 only in cytoplasm of the alloplasmatic line (squarrosa)-Penjamo 62. In certain hybrid cytoplasms, the display of the Lr1, Lr15, and Lr19 genes, in contrast to Lr9, varied with the virulence of the pathogen clones. 15 refs., 5 tabs.

  11. Analyses of promoter-proximal pausing by RNA polymerase II on the hsp70 heat shock gene promoter in a Drosophila nuclear extract.

    PubMed Central

    Li, B; Weber, J A; Chen, Y; Greenleaf, A L; Gilmour, D S

    1996-01-01

    Analyses of Drosophila cells have revealed that RNA polymerase II is paused in a region 20 to 40 nucleotides downstream from the transcription start site of the hsp70 heat shock gene when the gene is not transcriptionally active. We have developed a cell-free system that reconstitutes this promoter-proximal pausing. The paused polymerase has been detected by monitoring the hyperreactivity of thymines in the transcription bubble toward potassium permanganate. The pattern of permanganate reactivity for the hsp70 promoter in the reconstituted system matches the pattern found on the promoter after it has been introduced back into files by P-element-mediated transposition. Matching patterns of permanganate reactivity are also observed for a non-heat shock promoter, the histone H3 promoter. Further analysis of the hsp70 promoter in the reconstituted system reveals that pausing does not depend on sequence-specific interactions located immediately downstream from the pause site. Sequences upstream from the TATA box influence the recruitment of polymerase rather than the efficiency of pausing. Kinetic analysis indicates that the polymerase rapidly enters the paused state and remains stably in this state for at least 25 min. Further analysis shows that the paused polymerase will initially resume elongation when Sarkosyl is added but loses this capacity within minutes of pausing. Using an alpha-amanitin-resistant polymerase, we provide evidence that promoter-proximal pausing does not require the carboxy-terminal domain of the polymerase. PMID:8816456

  12. TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

    PubMed

    Alpern, Daniil; Langer, Diana; Ballester, Benoit; Le Gras, Stephanie; Romier, Christophe; Mengus, Gabrielle; Davidson, Irwin

    2014-09-10

    The functions of the TAF subunits of mammalian TFIID in physiological processes remain poorly characterised. In this study, we describe a novel function of TAFs in directing genomic occupancy of a transcriptional activator. Using liver-specific inactivation in mice, we show that the TAF4 subunit of TFIID is required for post-natal hepatocyte maturation. TAF4 promotes pre-initiation complex (PIC) formation at post-natal expressed liver function genes and down-regulates a subset of embryonic expressed genes by increased RNA polymerase II pausing. The TAF4-TAF12 heterodimer interacts directly with HNF4A and in vivo TAF4 is necessary to maintain HNF4A-directed embryonic gene expression at post-natal stages and promotes HNF4A occupancy of functional cis-regulatory elements adjacent to the transcription start sites of post-natal expressed genes. Stable HNF4A occupancy of these regulatory elements requires TAF4-dependent PIC formation highlighting that these are mutually dependent events. Local promoter-proximal HNF4A-TFIID interactions therefore act as instructive signals for post-natal hepatocyte differentiation.

  13. A tetra­nuclear cubane-like nickel(II) complex with a tridentate salicyl­idene­imine Schiff base ligand: tetra­kis­[μ3-4-methyl-N-(2-oxidophen­yl)salicylideneiminato]tetra­kis­[methano­lnickel(II)] methanol 0.8-solvate

    PubMed Central

    Pavlović, Gordana; Majer, Mihael; Cindrić, Marina

    2016-01-01

    The tetra­nuclear title complex, [Ni4(C14H11NO2)4(CH3OH)4]·0.8CH3OH, has a distorted cubane topology shaped by four Schiff base ligands. The cubane [Ni4(μ3-O4)] core is formed via the O atoms from the Schiff base ligands. The octa­hedrally coordinated NiII ions occupy alternating vertices of the cube. Each NiII ion is coordinated by one O,N,O′-tridentate dianionic ligand, two O atoms of oxidophenyl groups from adjacent ligands and the O atom of a coordinating methanol mol­ecule. The cubane core is stabilized via an intra­molecular O—H⋯O hydrogen bond between the hy­droxy group of the coordinating methanol mol­ecules and the phenolate O atom of the aldehyde Schiff base fragment. Additional stabilization is obtained via intra­molecular C—H⋯O hydrogen bonds involving aromatic C—H groups and the oxygen atoms of adjacent methanol mol­ecules. In the crystal, complex mol­ecules are linked into chains parallel to the c axis via weak C—H⋯O hydrogen bonds. The partial-occupancy disordered methanol solvent mol­ecule has a site occupancy of 0.8 and is linked to the tetra­nuclear unit via an inter­molecular C—H⋯O hydrogen bond involving a phenolate O atom. PMID:27980828

  14. Nuclear corroboration of DNA-DNA hybridization in deep phylogenies of hummingbirds, swifts, and passerines: the phylogenetic utility of ZENK (ii).

    PubMed

    Chubb, Alison L

    2004-01-01

    This paper documents the phylogenetic utility of ZENK at the avian intra-ordinal level using hummingbirds, swifts, and passerines as case studies. ZENK sequences (1.7 kb) were used to reconstruct separate gene trees containing the major lineages of each group, and the three trees were examined for congruence with existing DNA-DNA hybridization trees. The results indicate both that ZENK is an appropriate nuclear marker for resolving relationships deep in the avian tree, and that many relationships within these three particular groups are congruent among the different datasets. Specifically, within hummingbirds there was topological agreement that the major hummingbird lineages diverged in a graded manner from the "hermits," to the "mangoes," to the "coquettes," to the "emeralds," and finally to a sister relationship between the "mountain-gems" and the "bees." Concerning swifts, the deepest divergences were congruent: treeswifts (Hemiprocnidae) were sister to the typical swifts (Apodidae), and the subfamily Apodinae was monophyletic relative to Cypseloidinae. Within Apodinae, however, were short, unresolved branches among the swiftlets, spinetails, and more typical swifts; a finding which coincides with other datasets. Within passerine birds, there was congruent support for monophyly of sub-oscines and oscines, and within sub-oscines, for monophyly of New World groups relative to the Old World lineages. New World sub-oscines split into superfamilies Furnaroidea and Tyrannoidea, with the Tyrannoid relationships completely congruent among ZENK and DNA-DNA hybridization trees. Within Furnaroidea, however, there was some incongruence regarding the positions of Thamnophilidae and Formicariidae. Concerning oscine passerines, both datasets showed a split between Corvida and Passerida and confirmed the traditional membership of passerid superfamilies Muscicapoidea and Passeroidea. Monophyly of Sylvioidea, however, remained uncertain, as did the relationships among the

  15. Nuclear magnetic resonance studies of ancient buried wood-II. Observations on the origin of coal from lignite to bituminous coal

    USGS Publications Warehouse

    Hatcher, P.G.; Breger, I.A.; Szeverenyi, N.; Maciel, G.E.

    1982-01-01

    Coalified logs ranging in age from Late Pennsylvania to Miocene and in rank from lignite B to bituminous coal were analyzed by 13C nuclear magnetic resonance (NMR) utilizing the cross-polarization, magic-angle spinning technique, as well as by infrared spectroscopy. The results of this study indicate that at least three major stages of coalification can be observed as wood gradually undergoes transformation to bituminous coal. The first stage involves hydrolysis and loss of cellulose from wood with retention and differential concentration of the resistant lignin. The second stage involves conversion of the lignin residues directly to coalified wood of lignitic rank, during which the oxygen content of intermediate diagenetic products remains constant as the hydrogen content and the carbon content increases. These changes are thought to involve loss of methoxyl groups, water, and C3 side chains from the lignin. In the third major stage of coalification, the coalified wood increases in rank to subbituminous and bituminous coal; during this stage the oxygen content decreases, hydrogen remains constant, and the carbon content increases. These changes are thought to result from loss of soluble humic acids that are rich in oxygen and that are mobilized during compaction and dewatering. Relatively resistant resinous substances are differentially concentrated in the coal during this stage. The hypothesis that humic acids are formed as mobile by-products of the coalification of lignin and function only as vehicles for removal of oxygen represents a dramatic departure from commonly accepted views that they are relatively low-molecular-weight intermediates formed during the degradation of lignin that then condense to form high-molecular-weight coal structures. ?? 1982.

  16. Gd(iii) and Mn(ii) complexes for dynamic nuclear polarization: small molecular chelate polarizing agents and applications with site-directed spin labeling of proteins.

    PubMed

    Kaushik, Monu; Bahrenberg, Thorsten; Can, Thach V; Caporini, Marc A; Silvers, Robert; Heiliger, Jörg; Smith, Albert A; Schwalbe, Harald; Griffin, Robert G; Corzilius, Björn

    2016-10-21

    We investigate complexes of two paramagnetic metal ions Gd(3+) and Mn(2+) to serve as polarizing agents for solid-state dynamic nuclear polarization (DNP) of (1)H, (13)C, and (15)N at magnetic fields of 5, 9.4, and 14.1 T. Both ions are half-integer high-spin systems with a zero-field splitting and therefore exhibit a broadening of the mS = -1/2 ↔ +1/2 central transition which scales inversely with the external field strength. We investigate experimentally the influence of the chelator molecule, strong hyperfine coupling to the metal nucleus, and deuteration of the bulk matrix on DNP properties. At small Gd-DOTA concentrations the narrow central transition allows us to polarize nuclei with small gyromagnetic ratio such as (13)C and even (15)N via the solid effect. We demonstrate that enhancements observed are limited by the available microwave power and that large enhancement factors of >100 (for (1)H) and on the order of 1000 (for (13)C) can be achieved in the saturation limit even at 80 K. At larger Gd(iii) concentrations (≥10 mM) where dipolar couplings between two neighboring Gd(3+) complexes become substantial a transition towards cross effect as dominating DNP mechanism is observed. Furthermore, the slow spin-diffusion between (13)C and (15)N, respectively, allows for temporally resolved observation of enhanced polarization spreading from nuclei close to the paramagnetic ion towards nuclei further removed. Subsequently, we present preliminary DNP experiments on ubiquitin by site-directed spin-labeling with Gd(3+) chelator tags. The results hold promise towards applications of such paramagnetically labeled proteins for DNP applications in biophysical chemistry and/or structural biology.

  17. Nuclear DNA PCR-RFLPs that distinguish African and European honey bee groups of subspecies. II: Conversion of long PCR markers to standard PCR.

    PubMed

    Suazo, Alonso; Hall, H Glenn

    2002-08-01

    Nuclear DNA PCR-RFLPs previously found in amplifications of three long (> 5 kbp) anonymous regions of DNA were made analyzable using standard PCR procedures. RFLP analyses were simplified by restricting the amplifications to sections, within each locus, that contained most of the informative polymorphic sites. AluI digests of locus L-1 section 2 (L-1S2) revealed three suballeles of which one was African-specific (Apis mellifera scutellata Lepeletier) and one was east European-predominant (A. m. ligustica Spinola, A. m. carnica Pollman, and A. m. caucasica Gorbachev). Alleles found originally at locus L-2 with AvaI were determined in RFLP analysis of two sections, L-2S1int and L-2S2, resulting in two African-specific and two east European-predominant suballeles. Suballele identity was determined by the combination of banding patterns from both fragments. Polymorphisms revealed by HaeIII in locus L-2 were analyzed in amplifications and digests of L-2SM1int. an 830 bpfragment within L-2S1. Seven suballeles were found of which two were African-specific and three were east European-specific or predominant, including one suballele specific to the east European subspecies A. m. caucasica. In locus L-5, RFLPs were detected with HaeIII, DdeI, and SpeI. HaeIII polymorphisms were analyzed by amplification and digestion offragments L-5S1xt and L-5S1ter: Five suballeles were found of which three were African-specific and one east European-predominant. For DdeI, all five alleles originally found with long PCR could be identified in RFLP analyses of three sections. Two African-specific, one east European-specific, and one west European-predominant (A. m. mellifera L. and A. m. iberica Goetze) suballeles were found. A west European-predominant suballele was also found in RFLP analysis of L-5S3 with SpeI. Allele frequency data from Old World and US. populations are presented.

  18. Radiological investigations at the "Taiga" nuclear explosion site, part II: man-made γ-ray emitting radionuclides in the ground and the resultant kerma rate in air.

    PubMed

    Ramzaev, V; Repin, V; Medvedev, A; Khramtsov, E; Timofeeva, M; Yakovlev, V

    2012-07-01

    Samples of soil and epigeic lichens were collected from the "Taiga" peaceful nuclear explosion site (61.30°N 56.60°E, the Perm region, Russia) in 2009 and analyzed using high resolution γ-ray spectrometry. For soil samples obtained at six different plots, two products of fission ((137)Cs and (155)Eu), five products of neutron activation ((60)Co, (94)Nb, (152)Eu, (154)Eu, (207)Bi) and (241)Am have been identified and quantified. The maximal activity concentrations of (60)Co, (137)Cs, and (241)Am for the soils samples were measured as 1650, 7100, and 6800 Bq kg(-1) (d.w.), respectively. The deposit of (137)Cs for the top 20 cm of soil on the tested plots at the "Taiga" site ranged from 30 to 1020 kBq m(-2); the maximal value greatly (by almost 3 orders of magnitude) exceeded the regional background (from global fallout) level of 1.4 kBq m(-2). (137)Cs contributes approximately 57% of the total ground inventory of the man-made γ-ray emitters for the six plots tested at the "Taiga" site. The other major radionuclides -(241)Am and (60)Co, constitute around 40%. Such radionuclides as (60)Co, (137)Cs, (241)Am, and (207)Bi have also been determined for the epigeic lichens (genera Cladonia) that colonized certain areas at the ground lip produced by the "Taiga" explosion. Maximal activity concentrations (up to 80 Bq kg(-1) for (60)Co, 580 Bq kg(-1) for (137)Cs, 200 Bq kg(-1) for (241)Am, and 5 Bq kg(-1) for (207)Bi; all are given in terms of d.w.) have been detected for the lower dead section of the organisms. The air kerma rates associated with the anthropogenic sources of gamma radiation have been calculated using the data obtained from the laboratory analysis. For the six plots tested, the kerma rates ranged from 50 to 1200 nGy h(-1); on average, 51% of the dose can be attributed to (137)Cs and 45% to (60)Co. These estimates agree reasonably well with the results of the in situ measurements made during our field survey of the "Taiga" site in August

  19. Nuclear Scans

    MedlinePlus

    Nuclear scans use radioactive substances to see structures and functions inside your body. They use a special ... images. Most scans take 20 to 45 minutes. Nuclear scans can help doctors diagnose many conditions, including ...

  20. Nuclear Winter.

    ERIC Educational Resources Information Center

    Ehrlich, Anne

    1984-01-01

    "Nuclear Winter" was recently coined to describe the climatic and biological effects of a nuclear war. These effects are discussed based on models, simulations, scenarios, and projections. Effects on human populations are also considered. (JN)

  1. Nuclear Chemistry.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1979

    1979-01-01

    Provides a brief review of the latest developments in nuclear chemistry. Nuclear research today is directed toward increased activity in radiopharmaceuticals and formation of new isotopes by high-energy, heavy-ion collisions. (Author/BB)

  2. Nuclear weapons, nuclear effects, nuclear war

    SciTech Connect

    Bing, G.F.

    1991-08-20

    This paper provides a brief and mostly non-technical description of the militarily important features of nuclear weapons, of the physical phenomena associated with individual explosions, and of the expected or possible results of the use of many weapons in a nuclear war. Most emphasis is on the effects of so-called ``strategic exchanges.``

  3. Nuclear Fuels.

    ERIC Educational Resources Information Center

    Nash, J. Thomas

    1983-01-01

    Trends in and factors related to the nuclear industry and nuclear fuel production are discussed. Topics addressed include nuclear reactors, survival of the U.S. uranium industry, production costs, budget cuts by the Department of Energy and U.S. Geological survey for resource studies, mining, and research/development activities. (JN)

  4. Swedish nuclear waste efforts

    SciTech Connect

    Rydberg, J.

    1981-09-01

    After the introduction of a law prohibiting the start-up of any new nuclear power plant until the utility had shown that the waste produced by the plant could be taken care of in an absolutely safe way, the Swedish nuclear utilities in December 1976 embarked on the Nuclear Fuel Safety Project, which in November 1977 presented a first report, Handling of Spent Nuclear Fuel and Final Storage of Vitrified Waste (KBS-I), and in November 1978 a second report, Handling and Final Storage of Unreprocessed Spent Nuclear Fuel (KBS II). These summary reports were supported by 120 technical reports prepared by 450 experts. The project engaged 70 private and governmental institutions at a total cost of US $15 million. The KBS-I and KBS-II reports are summarized in this document, as are also continued waste research efforts carried out by KBS, SKBF, PRAV, ASEA and other Swedish organizations. The KBS reports describe all steps (except reprocessing) in handling chain from removal from a reactor of spent fuel elements until their radioactive waste products are finally disposed of, in canisters, in an underground granite depository. The KBS concept relies on engineered multibarrier systems in combination with final storage in thoroughly investigated stable geologic formations. This report also briefly describes other activities carried out by the nuclear industry, namely, the construction of a central storage facility for spent fuel elements (to be in operation by 1985), a repository for reactor waste (to be in operation by 1988), and an intermediate storage facility for vitrified high-level waste (to be in operation by 1990). The R and D activities are updated to September 1981.

  5. Calcium-aluminum-rich inclusions with fractionation and unidentified nuclear effects (FUN CAIs): II. Heterogeneities of magnesium isotopes and 26Al in the early Solar System inferred from in situ high-precision magnesium-isotope measurements

    NASA Astrophysics Data System (ADS)

    Park, Changkun; Nagashima, Kazuhide; Krot, Alexander N.; Huss, Gary R.; Davis, Andrew M.; Bizzarro, Martin

    2017-03-01

    Calcium-aluminum-rich inclusions with isotopic mass fractionation effects and unidentified nuclear isotopic anomalies (FUN CAIs) have been studied for more than 40 years, but their origins remain enigmatic. Here we report in situ high precision measurements of aluminum-magnesium isotope systematics of FUN CAIs by secondary ion mass spectrometry (SIMS). Individual minerals were analyzed in six FUN CAIs from the oxidized CV3 carbonaceous chondrites Axtell (compact Type A CAI Axtell 2271) and Allende (Type B CAIs C1 and EK1-4-1, and forsterite-bearing Type B CAIs BG82DH8, CG-14, and TE). Most of these CAIs show evidence for excess 26Mg due to the decay of 26Al. The inferred initial 26Al/27Al ratios [(26Al/27Al)0] and the initial magnesium isotopic compositions (δ26Mg0) calculated using an exponential law with an exponent β of 0.5128 are (3.1 ± 1.6) × 10-6 and 0.60 ± 0.10‰ (Axtell 2271), (3.7 ± 1.5) × 10-6 and -0.20 ± 0.05‰ (BG82DH8), (2.2 ± 1.1) × 10-6 and -0.18 ± 0.05‰ (C1), (2.3 ± 2.4) × 10-5 and -2.23 ± 0.37‰ (EK1-4-1), (1.5 ± 1.1) × 10-5 and -0.42 ± 0.08‰ (CG-14), and (5.3 ± 0.9) × 10-5 and -0.05 ± 0.08‰ (TE) with 2σ uncertainties. We infer that FUN CAIs recorded heterogeneities of magnesium isotopes and 26Al in the CAI-forming region(s). Comparison of 26Al-26Mg systematics, stable isotope (oxygen, magnesium, calcium, and titanium) and trace element studies of FUN and non-FUN igneous CAIs indicates that there is a continuum among these CAI types. Based on these observations and evaporation experiments on CAI-like melts, we propose a generic scenario for the origin of igneous (FUN and non-FUN) CAIs: (i) condensation of isotopically normal solids in an 16O-rich gas of approximately solar composition; (ii) formation of CAI precursors by aggregation of these solids together with variable abundances of isotopically anomalous grains-possible carriers of unidentified nuclear (UN) effects; and (iii) melt evaporation of these precursors

  6. START II and beyond

    SciTech Connect

    Mendelsohn, J.

    1996-10-01

    The second Strategic Arms Reduction Treaty (START II), signed by President George Bush and Russian President Boris yeltsin in January 1993, was ratified by the US Senate in January 1996 by and overwhelming vote of 87-4. The treaty, which will slash the strategic arsenals of the United States and Russia to 3,000-3,500 warheads each, is now before the two houses of the Russian Parliament (the Duma and the Federation Council) awaiting ratification amidst confusion and criticism. The Yeltsin administration supports START II and spoke in favor of Russian ratification after the Senate acted on the treaty. The Russian foreign minister and the Russian military believed that START II should be ratified as soon as possible. During the recent presidential campaign and his subsequent illness, President Yeltsin has been virtually silent on the subject of START II and nuclear force reductions. Without a push from the Yeltsin administration, the tone among Duma members, has been sharply critical of START II. Voices across the Russian political spectrum have questioned the treaty and linked it to constraints on highly capable theater missile defense (TMD) systems and the continued viability of the ABM Treaty. And urged that START II ratification be held hostage until NATO abandons its plans to expand eastward. Although the START I and START II accords have generated the momentum, opportunity and expectation-both domestic and international-for additional nuclear arms reductions, the current impasse over ratification in the Duma has cast a shadow over the future of START II and raised questions about the chances for any follow-on (START III) agreement.

  7. Nuclear astrophysics

    SciTech Connect

    Haxton, W.C.

    1992-01-01

    The problem of core-collapse supernovae is used to illustrate the many connections between nuclear astrophysics and the problems nuclear physicists study in terrestrial laboratories. Efforts to better understand the collapse and mantle ejection are also motivated by a variety of interdisciplinary issues in nuclear, particle, and astrophysics, including galactic chemical evolution, neutrino masses and mixing, and stellar cooling by the emission of new particles. The current status of theory and observations is summarized.

  8. Nuclear astrophysics

    SciTech Connect

    Haxton, W.C.

    1992-12-31

    The problem of core-collapse supernovae is used to illustrate the many connections between nuclear astrophysics and the problems nuclear physicists study in terrestrial laboratories. Efforts to better understand the collapse and mantle ejection are also motivated by a variety of interdisciplinary issues in nuclear, particle, and astrophysics, including galactic chemical evolution, neutrino masses and mixing, and stellar cooling by the emission of new particles. The current status of theory and observations is summarized.

  9. Nuclear Fission

    NASA Astrophysics Data System (ADS)

    Denschlag, J. O.

    This chapter first gives a survey on the history of the discovery of nuclear fission. It briefly presents the liquid-drop and shell models and their application to the fission process. The most important quantities accessible to experimental determination such as mass yields, nuclear charge distribution, prompt neutron emission, kinetic energy distribution, ternary fragment yields, angular distributions, and properties of fission isomers are presented as well as the instrumentation and techniques used for their measurement. The contribution concentrates on the fundamental aspects of nuclear fission. The practical aspects of nuclear fission are discussed in http://dx.doi.org/10.1007/978-1-4419-0720-2_57 of Vol. 6.

  10. Di/mono-nuclear iron(I)/(II) complexes as functional models for the 2Fe2S subunit and distal Fe moiety of the active site of [FeFe] hydrogenases: protonations, molecular structures and electrochemical properties.

    PubMed

    Gao, Shang; Fan, Jiangli; Sun, Shiguo; Song, Fengling; Peng, Xiaojun; Duan, Qian; Jiang, Dayong; Liang, Qingcheng

    2012-10-21

    Di/mono-nuclear iron(I)/(II) complexes containing conjugated and electron-withdrawing S-to-S linkers, [{(μ-S)(2)(C(4)N(2)H(2))}Fe(2)(CO)(6)] (1), [{(μ-S)(2)(C(4)N(2)H(2))}Fe(2)(CO)(5)(PMe(3))] (1P), and [{(μ-S)(2)(C(4)N(2)H(2))}Fe(CO)(2)(PMe(3))(2)] (2) were prepared as biomimetic models for the 2Fe2S subunit and distal Fe moiety of the active site of [FeFe] hydrogenases. The N atoms in the heterocyclic pyrazines of 1 and 2 were protonated in the presence of proton acid to generate one and two hydrides, [1(NH)](+) CF(3)SO(3)(-), [2(NH)](+) CF(3)SO(3)(-), and [2(NH)(2)](2+) (CF(3)SO(3)(-))(2), respectively. The protonation processes were evidenced by in situ IR and NMR spectroscopy. The molecular structures of the protonated species [1(NH)](+) CF(3)SO(3)(-) and [2(NH)(2)](2+) (CF(3)SO(3)(-))(2) together with their originating complexes and , and the mono-PMe(3) substituted diiron complex were identified by X-ray crystallography. The IR and single-crystal analysis data all suggested that the electron-withdrawing bridge, pyrazine, led to decreased electron density at the Fe centers of the model complexes, which was consistent with the electrochemical studies. The cyclic voltammograms indicated that complex exhibited a low primary reduction potential at -1.17 V vs. Fc-Fc(+) with a 270 mV positive shift compared with that of the benzene-1,2-dithiolate (bdt) bridged analogue [(μ-bdt)Fe(2)(CO)(6)]. Under the weak acid conditions, complexes 1 and 2 could electrochemically catalyze the proton reduction. More interestingly, the mononuclear ferrous complex 2 showed two catalytic peaks during the formation of hydrogen, confirming its potential as a catalyst for hydrogen production.

  11. Nuclear safety

    NASA Technical Reports Server (NTRS)

    Buden, D.

    1991-01-01

    Topics dealing with nuclear safety are addressed which include the following: general safety requirements; safety design requirements; terrestrial safety; SP-100 Flight System key safety requirements; potential mission accidents and hazards; key safety features; ground operations; launch operations; flight operations; disposal; safety concerns; licensing; the nuclear engine for rocket vehicle application (NERVA) design philosophy; the NERVA flight safety program; and the NERVA safety plan.

  12. Nuclear privatization

    SciTech Connect

    Jeffs, E.

    1995-11-01

    The United Kingdom government announced in May 1995 plans to privatize the country`s two nuclear generating companies, Nuclear Electric and Scottish Nuclear. Under the plan, the two companies will become operating divisions of a unified holding company, to be called British Electric, with headquarters in Scotland. Britain`s nuclear plants were left out of the initial privatization in 1989 because the government believed the financial community would be unwilling to accept the open-ended liability of decommissioning the original nine stations based on the Magnox gas-cooled reactor. Six years later, the government has found a way around this by retaining these power stations in state ownership, leaving the new nuclear company with the eight Advanced Gas-cooled Reactor (AGR) stations and the recently completed Sizewell B PWR stations. The operating Magnox stations are to be transferred to BNFL, which operates two Magnox stations of their own at Calder Hall and Chapelcross.

  13. Options Study - Phase II

    SciTech Connect

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2010-09-01

    The Options Study has been conducted for the purpose of evaluating the potential of alternative integrated nuclear fuel cycle options to favorably address the issues associated with a continuing or expanding use of nuclear power in the United States. The study produced information that can be used to inform decisions identifying potential directions for research and development on such fuel cycle options. An integrated nuclear fuel cycle option is defined in this study as including all aspects of the entire nuclear fuel cycle, from obtaining natural resources for fuel to the ultimate disposal of used nuclear fuel (UNF) or radioactive wastes. Issues such as nuclear waste management, especially the increasing inventory of used nuclear fuel, the current uncertainty about used fuel disposal, and the risk of nuclear weapons proliferation have contributed to the reluctance to expand the use of nuclear power, even though it is recognized that nuclear power is a safe and reliable method of producing electricity. In this Options Study, current, evolutionary, and revolutionary nuclear energy options were all considered, including the use of uranium and thorium, and both once-through and recycle approaches. Available information has been collected and reviewed in order to evaluate the ability of an option to clearly address the challenges associated with the current implementation and potential expansion of commercial nuclear power in the United States. This Options Study is a comprehensive consideration and review of fuel cycle and technology options, including those for disposal, and is not constrained by any limitations that may be imposed by economics, technical maturity, past policy, or speculated future conditions. This Phase II report is intended to be used in conjunction with the Phase I report, and much information in that report is not repeated here, although some information has been updated to reflect recent developments. The focus in this Options Study was to

  14. Nuclear stress test

    MedlinePlus

    ... Persantine stress test; Thallium stress test; Stress test - nuclear; Adenosine stress test; Regadenoson stress test; CAD - nuclear stress; Coronary artery disease - nuclear stress; Angina - nuclear ...

  15. Nuclear reprogramming.

    PubMed

    Halley-Stott, Richard P; Pasque, Vincent; Gurdon, J B

    2013-06-01

    There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the development of human disease models and patient-specific tissue-replacement therapies. Here, we introduce the field of nuclear reprogramming and briefly discuss six of the procedures by which reprogramming may be experimentally performed: nuclear transfer to eggs or oocytes, cell fusion, extract treatment, direct reprogramming to pluripotency and transdifferentiation.

  16. Nuclear Speckles

    PubMed Central

    Spector, David L.; Lamond, Angus I.

    2011-01-01

    Nuclear speckles, also known as interchromatin granule clusters, are nuclear domains enriched in pre-mRNA splicing factors, located in the interchromatin regions of the nucleoplasm of mammalian cells. When observed by immunofluorescence microscopy, they usually appear as 20–50 irregularly shaped structures that vary in size. Speckles are dynamic structures, and their constituents can exchange continuously with the nucleoplasm and other nuclear locations, including active transcription sites. Studies on the composition, structure, and dynamics of speckles have provided an important paradigm for understanding the functional organization of the nucleus and the dynamics of the gene expression machinery. PMID:20926517

  17. (Nuclear theory). [Research in nuclear physics

    SciTech Connect

    Haxton, W.

    1990-01-01

    This report discusses research in nuclear physics. Topics covered in this paper are: symmetry principles; nuclear astrophysics; nuclear structure; quark-gluon plasma; quantum chromodynamics; symmetry breaking; nuclear deformation; and cold fusion. (LSP)

  18. Linoleic acid-induced expression of inducible nitric oxide synthase and cyclooxygenase II via p42/44 mitogen-activated protein kinase and nuclear factor-kappaB pathway in retinal pigment epithelial cells.

    PubMed

    Fang, I-Mo; Yang, Chang-Hao; Yang, Chung-May; Chen, Muh-Shy

    2007-11-01

    High linoleic acid (LA) intake is known to correlate with age-related macular degeneration (AMD), but the molecular mechanisms remain unclear. This study was conducted to investigate the effects of LA on expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase II (COX-2) and their associated signaling pathways in human retinal pigment epithelial (RPE) cells. ARPE-19 cells were treated with different concentrations of LA. Expressions of iNOS and COX-2 were examined using semiquantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. Concentrations of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in the culture medium were determined by enzyme-link immunosorbent assay (ELISA). Activation of p42/44, p38, JNK mitogen-activated protein kinase (MAPK) and nuclear factors (NF)-kappaB were evaluated by Western blot analysis and electrophoretic mobility shift assay (EMSA). We found that LA induced expression of iNOS and COX-2 in RPE cells at the mRNA and protein levels in a time-and dose-dependent manner. Upregulation of iNOS and COX-2 resulted in increased production of NO and PGE(2). Moreover, LA caused degradation of IkappaB and increased NF-kappaB DNA binding activity. Effects of LA-induced iNOS and COX-2 expression were inhibited by a NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC). LA activated p42/44, but not p38 or JNK MAPK. Inhibition of p42/44 activity by PD98059 significantly reduced LA-induced activation of NF-kappaB. Linoleic acid-induced expression of iNOS and COX-2 as well as PGE(2) and NO release in RPE cells were sequentially mediated through activation of p42/p44, MAPK, then NF-kappaB. These results may provide new insights into both mechanisms of LA action on RPE cells and pathogenesis of age-related macular degeneration.

  19. Nuclear battlefields

    SciTech Connect

    Arkin, W.M.; Fieldhouse, R.W.

    1985-01-01

    This book provides complete data on the nuclear operations and research facilities in the U.S.A., the U.S.S.R., France, China and the U.K. It describes detailed estimates on the U.S.S.R.'s nuclear stockpile for over 500 locations. It shows how non-nuclear countries cooperate with the world-wide war machine. And it maps the U.S. nuclear facilities from Little America, WY, and Charleston, SC, to the battleships patroling the world's oceans and subs stalking under the sea. The data were gathered from unclassified sources through the Freedom of Information Act, from data supplied to military installations, and from weapons source books. It provides guidance for policymakers, government and corporate officials.

  20. NUCLEAR REACTOR

    DOEpatents

    Sherman, J.; Sharbaugh, J.E.; Fauth, W.L. Jr.; Palladino, N.J.; DeHuff, P.G.

    1962-10-23

    A nuclear reactor incorporating seed and blanket assemblies is designed. Means are provided for obtaining samples of the coolant from the blanket assemblies and for varying the flow of coolant through the blanket assemblies. (AEC)

  1. Nuclear Medicine

    MedlinePlus

    ... here Home » Science Education » Science Topics » Nuclear Medicine SCIENCE EDUCATION SCIENCE EDUCATION Science Topics Resource Links for ... administered by inhalation, by oral ingestion, or by direct injection into an organ. The mode of tracer ...

  2. Nuclear accidents

    SciTech Connect

    Mobley, J.A.

    1982-05-01

    A nuclear accident with radioactive contamination can happen anywhere in the world. Because expert nuclear emergency teams may take several hours to arrive at the scene, local authorities must have a plan of action for the hours immediately following an accident. The site should be left untouched except to remove casualties. Treatment of victims includes decontamination and meticulous wound debridement. Acute radiation syndrome may be an overwhelming sequela.

  3. Nuclear cardiac

    SciTech Connect

    Slutsky, R.; Ashburn, W.L.

    1982-01-01

    The relationship between nuclear medicine and cardiology has continued to produce a surfeit of interesting, illuminating, and important reports involving the analysis of cardiac function, perfusion, and metabolism. To simplify the presentation, this review is broken down into three major subheadings: analysis of myocardial perfusion; imaging of the recent myocardial infarction; and the evaluation of myocardial function. There appears to be an increasingly important relationship between cardiology, particularly cardiac physiology, and nuclear imaging techniques. (KRM)

  4. Nuclear Data

    SciTech Connect

    White, Morgan C.

    2014-01-23

    PowerPoint presentation targeted for educational use. Nuclear data comes from a variety of sources and in many flavors. Understanding where the data you use comes from and what flavor it is can be essential to understand and interpret your results. This talk will discuss the nuclear data pipeline with particular emphasis on providing links to additional resources that can be used to explore the issues you will encounter.

  5. Nuclear Nonproliferation

    SciTech Connect

    Atkins-Duffin, C E

    2008-12-10

    With an explosion equivalent of about 20kT of TNT, the Trinity test was the first demonstration of a nuclear weapon. Conducted on July 16, 1945 in Alamogordo, NM this site is now a Registered National Historic Landmark. The concept and applicability of nuclear power was demonstrated on December 20, 1951 with the Experimental Breeder Reactor Number One (EBR-1) lit four light bulbs. This reactor is now a Registered National Historic Landmark, located near Arco, ID. From that moment forward it had been clearly demonstrated that nuclear energy has both peaceful and military applications and that the civilian and military fuel cycles can overlap. For the more than fifty years since the Atoms for Peace program, a key objective of nuclear policy has been to enable the wider peaceful use of nuclear energy while preventing the spread of nuclear weapons. Volumes have been written on the impact of these two actions on the world by advocates and critics; pundits and practioners; politicians and technologists. The nations of the world have woven together a delicate balance of treaties, agreements, frameworks and handshakes that are representative of the timeframe in which they were constructed and how they have evolved in time. Collectively these vehicles attempt to keep political will, nuclear materials and technology in check. This paper captures only the briefest abstract of the more significant aspects on the Nonproliferation Regime. Of particular relevance to this discussion is the special nonproliferation sensitivity associated with the uranium isotope separation and spent fuel reprocessing aspects of the nuclear fuel cycle.

  6. Nuclear telemedicine

    NASA Astrophysics Data System (ADS)

    Morrison, R. T.; Szasz, I. J.

    1990-06-01

    Diagnostic nuclear medicine patient images have been transniitted for 8 years from a regional conununity hospital to a university teaching hospital 700 kiloinetres away employing slow scan TV and telephone. Transruission and interpretation were done at the end of each working day or as circumstances required in cases of emergencies. Referring physicians received the nuclear medicine procedure report at the end of the completion day or within few minutes of completion in case of emergency procedures. To date more than 25 patient studies have been transmitted for interpretation. Blinded reinterpretation of the original hard copy data of 350 patient studies resulted in 100 agreement with the interpretation of transmitted data. This technique provides high quality diagnostic and therapeutic nuclear medicine services in remote hospitals where the services of an on-site nuclear physician is not available. 2. HISTORY Eight years ago when the nuclear medicine physician at Trail Regional Hospital left the Trail area and an other could not be recruited we examined the feasibility of image transmission by phone for interpretation since closing the department would have imposed unacceptable physical and financial hardship and medical constraints on the patient population the nearest nuclear medicine facility was at some 8 hours drive away. In hospital patients would have to be treated either based purely on physical findings or flown to Vancouver at considerable cost to the health care system (estimated cost $1500.

  7. The Bad News and the Good about Nuclear Careers.

    ERIC Educational Resources Information Center

    Basta, Nicholas

    1986-01-01

    Traces the changes in the nuclear energy field since World War II, citing distinct periods of growth in the nuclear industry, as well as downtrends. Analyzes the reasons for the changes in public support for nuclear energy and the impact upon careers in the field. (TW)

  8. Children's (Pediatric) Nuclear Medicine

    MedlinePlus Videos and Cool Tools

    ... Professions Site Index A-Z Children's (Pediatric) Nuclear Medicine Children’s (pediatric) nuclear medicine imaging uses small amounts ... Children's Nuclear Medicine? What is Children's (Pediatric) Nuclear Medicine? Nuclear medicine is a branch of medical imaging ...

  9. Nuclear risk

    SciTech Connect

    Levenson, M.

    1989-01-01

    The title of our session, Nuclear Risk Versus Other Power Options, is provocative. It is also a title with different meanings to different people. To the utility chief executive officer, nuclear power is a high-risk financial undertaking because of political and economic barriers to cost recovery. To the utility dispatcher, it is a high-risk future power source since plant completion and start-up dates can be delayed for very long times due to uncertain legal and political issues. To the environmentalist, concerned about global effects such as greenhouse and acid rain, nuclear power is a relatively low risk energy source. To the financial people, nuclear power is a cash cow turned sour because of uncertainties as to what new plants will cost and whether they will even be allowed to operate. The statistics on risk are known and the results of probability risk assessment calculations of risks are known. The challenge is not to make nuclear power safer, it is already one of the safest, if not the safest, source of power currently available. The challenge is to find a way to communicate this to the public.

  10. Nuclear waste

    SciTech Connect

    Not Available

    1988-05-01

    This paper discusses how, as part of the Department of Energy's implementation of the Nuclear Waste Policy Act of 1982, DOE is required to investigate a site at Yucca Mountain, Nevada and, if it determines that the site is suitable, recommend to the President its selection for a nuclear waste repository. The Nuclear Regulatory Commission, in considering development of the plan, issued five objections, one of which is DOE's failure to recognize the range of alternative conceptual models of the Yucca Mountain site that can be supported by the limited existing technical data. At the end of the quarter DOE directed its project offices in Washington and Texas to begin orderly phase-out of all site-specific repository activities. Costs for this phase-out are $53 million for the Deaf Smith site and $85 million for the Hanford site.

  11. Nuclear Models

    NASA Astrophysics Data System (ADS)

    Fossión, Rubén

    2010-09-01

    The atomic nucleus is a typical example of a many-body problem. On the one hand, the number of nucleons (protons and neutrons) that constitute the nucleus is too large to allow for exact calculations. On the other hand, the number of constituent particles is too small for the individual nuclear excitation states to be explained by statistical methods. Another problem, particular for the atomic nucleus, is that the nucleon-nucleon (n-n) interaction is not one of the fundamental forces of Nature, and is hard to put in a single closed equation. The nucleon-nucleon interaction also behaves differently between two free nucleons (bare interaction) and between two nucleons in the nuclear medium (dressed interaction). Because of the above reasons, specific nuclear many-body models have been devised of which each one sheds light on some selected aspects of nuclear structure. Only combining the viewpoints of different models, a global insight of the atomic nucleus can be gained. In this chapter, we revise the the Nuclear Shell Model as an example of the microscopic approach, and the Collective Model as an example of the geometric approach. Finally, we study the statistical properties of nuclear spectra, basing on symmetry principles, to find out whether there is quantum chaos in the atomic nucleus. All three major approaches have been rewarded with the Nobel Prize of Physics. In the text, we will stress how each approach introduces its own series of approximations to reduce the prohibitingly large number of degrees of freedom of the full many-body problem to a smaller manageable number of effective degrees of freedom.

  12. Nuclear pursuits

    SciTech Connect

    Not Available

    1993-05-01

    This table lists quantities of warheads (in stockpile, peak number per year, total number built, number of known test explosions), weapon development milestones (developers of the atomic bomb and hydrogen bomb, date of first operational ICBM, first nuclear-powered naval SSN in service, first MIRVed missile deployed), and testing milestones (first fission test, type of boosted fission weapon, multistage thermonuclear test, number of months from fission bomb to multistage thermonuclear bomb, etc.), and nuclear infrastructure (assembly plants, plutonium production reactors, uranium enrichment plants, etc.). Countries included in the tally are the United States, Soviet Union, Britain, France, and China.

  13. Theft and Diversion of Special Nuclear Materials and Military Nuclear Weapons

    DTIC Science & Technology

    1975-03-12

    7 II. Computed Probability per Year for Nuclear Diversion....... 10 III. Amount of U235 Compounds for One Critical Ms...15 IVo Probability of Success,for Making a Nuclear Weapon from UF6 . 19 V. Risk Assessments for Attempted Diversion of F....... 22 VIo Probability of...Richardson of the Nuclear Safety Division, is due special acknowledgment for their interest in the project, and for their financial aid in supporting

  14. Nuclear orbiting

    SciTech Connect

    Shapira, D.

    1988-01-01

    Nuclear orbiting following collisions between sd and p shell nuclei is discussed. The dependence of this process on the real and imaginary parts of the nucleus-nucleus potential is discussed, as well as the evolution of the dinucleus toward a fully equilibrated fused system. 26 refs., 15 figs.

  15. Nuclear Misinformation

    ERIC Educational Resources Information Center

    Ford, Daniel F.; Kendall, Henry W.

    1975-01-01

    Many scientists feel that research into nuclear safety has been diverted or distorted, and the results of the research concealed or inaccurately reported on a large number of occasions. Of particular concern have been the emergency cooling systems which have not, as yet, been adequately tested. (Author/MA)

  16. Nuclear Terrorism.

    SciTech Connect

    Hecker, Siegfried S.

    2001-01-01

    As pointed out by several speakers, the level of violence and destruction in terrorist attacks has increased significantly during the past decade. Fortunately, few have involved weapons of mass destruction, and none have achieved mass casualties. The Aum Shinrikyo release of lethal nerve agent, sarin, in the Tokyo subway on March 20, 1995 clearly broke new ground by crossing the threshold in attempting mass casualties with chemical weapons. However, of all weapons of mass destruction, nuclear weapons still represent the most frightening threat to humankind. Nuclear weapons possess an enormous destructive force. The immediacy and scale of destruction are unmatched. In addition to destruction, terrorism also aims to create fear among the public and governments. Here also, nuclear weapons are unmatched. The public's fear of nuclear weapons or, for that matter, of all radioactivity is intense. To some extent, this fear arises from a sense of unlimited vulnerability. That is, radioactivity is seen as unbounded in three dimensions - distance, it is viewed as having unlimited reach; quantity, it is viewed as having deadly consequences in the smallest doses (the public is often told - incorrectly, of course - that one atom of plutonium will kill); and time, if it does not kill you immediately, then it will cause cancer decades hence.

  17. Nuclear medicine

    SciTech Connect

    Wagner, H.N. Jr.

    1986-10-17

    In 1985 and 1986 nuclear medicine became more and more oriented toward in vov chemistry, chiefly as a result of advances in positron emission tomography (PET). The most important trend was the extension of PET technology into the care of patients with brain tumors, epilepsy, and heart disease. A second trend was the increasing use of single-photon emission computed tomography (SPECT).

  18. NUCLEAR REACTOR

    DOEpatents

    Treshow, M.

    1961-09-01

    A boiling-water nuclear reactor is described wherein control is effected by varying the moderator-to-fuel ratio in the reactor core. This is accomplished by providing control tubes containing a liquid control moderator in the reactor core and providing means for varying the amount of control moderatcr within the control tubes.

  19. Nuclear Science.

    ERIC Educational Resources Information Center

    Pennsylvania State Dept. of Education, Harrisburg. Bureau of Curriculum Services.

    This document is a report on a course in nuclear science for the high school curriculum. The course is designed to provide a basic but comprehensive understanding of the atom in the light of modern knowledge, and to show how people attempt to harness the tremendous energy liberated through fission and fusion reactions. The course crosses what are…

  20. Nuclear energy.

    PubMed

    Wilson, Peter D

    2010-01-01

    The technical principles and practices of the civil nuclear industry are described with particular reference to fission and its products, natural and artificial radioactivity elements principally concerned and their relationships, main types of reactor, safety issues, the fuel cycle, waste management, issues related to weapon proliferation, environmental considerations and possible future developments.

  1. Argentine nuclear development: capabilities and implications

    SciTech Connect

    Watson, C.A.

    1984-01-01

    Complacency was shattered in 1974 by the Indian explosion of a nuclear device developed from a civil nuclear program. The fear of nuclear weapon spread led the international system to consider the other states that could develop devices from what were assumed to be peaceful nuclear programs. Many states of the non-nuclear ranks, often the more developed states of the Third World, resented the nuclear suppliers weapon holders dictating to the developing states the types of technology that these states could handle. Some of these developing states had highly sophisticated nuclear programs that no longer rely on the suppliers for assistance. These states are using the options that their nuclear developments present in an attempt to alter the international system, or the balance of power, that has existed since the end of World War II. Argentina's nuclear program has become one of the most-sophisticated in the Third World. This work discusses the implications of the country's present capabilities as they affect Argentine actions in the foreign policy areas of nuclear commerce and the international nuclear weapons non-proliferation regime.

  2. Risk perspectives for TOPAZ II flight mission

    SciTech Connect

    Payne, A.C. Jr.; Haskin, F.E.

    1993-11-01

    The purpose of this paper is to present a preliminary estimate of the nuclear-related public health risk presented by launching and operating the Russian TOPAZ II space reactor as part of the Nuclear Electric Propulsion Space Test Program (NEPSTP). This risk is then compared to the risks from the operation of commercial nuclear power reactors and previously planned and/or launched space nuclear power missions. For the current mission profile, the initial estimate of the risk posed by launching and operating TOPAZ II is significantly less (at least two orders of magnitude) than that estimated for prior space nuclear missions. Even allowing for the large uncertainties in this estimate, it does not appear that the NEPSTP mission will present a significant health risk to the public.

  3. NUCLEAR REACTOR

    DOEpatents

    Anderson, C.R.

    1962-07-24

    A fluidized bed nuclear reactor and a method of operating such a reactor are described. In the design means are provided for flowing a liquid moderator upwardly through the center of a bed of pellets of a nentron-fissionable material at such a rate as to obtain particulate fluidization while constraining the lower pontion of the bed into a conical shape. A smooth circulation of particles rising in the center and falling at the outside of the bed is thereby established. (AEC)

  4. NUCLEAR REACTORS

    DOEpatents

    Long, E.; Ashby, J.W.

    1958-09-16

    ABS>A graphite moderator structure is presented for a nuclear reactor compriscd of an assembly of similarly orientated prismatic graphite blocks arranged on spaced longitudinal axes lying in common planes wherein the planes of the walls of the blocks are positioned so as to be twisted reintive to the planes of said axes so thatthe unlmpeded dtrect paths in direction wholly across the walls of the blocks are limited to the width of the blocks plus spacing between the blocks.

  5. NUCLEAR REACTOR

    DOEpatents

    Grebe, J.J.

    1959-07-14

    High temperature reactors which are uniquely adapted to serve as the heat source for nuclear pcwered rockets are described. The reactor is comprised essentially of an outer tubular heat resistant casing which provides the main coolant passageway to and away from the reactor core within the casing and in which the working fluid is preferably hydrogen or helium gas which is permitted to vaporize from a liquid storage tank. The reactor core has a generally spherical shape formed entirely of an active material comprised of fissile material and a moderator material which serves as a diluent. The active material is fabricated as a gas permeable porous material and is interlaced in a random manner with very small inter-connecting bores or capillary tubes through which the coolant gas may flow. The entire reactor is divided into successive sections along the direction of the temperature gradient or coolant flow, each section utilizing materials of construction which are most advantageous from a nuclear standpoint and which at the same time can withstand the operating temperature of that particular zone. This design results in a nuclear reactor characterized simultaneously by a minimum critiral size and mass and by the ability to heat a working fluid to an extremely high temperature.

  6. Nuclear waste

    SciTech Connect

    Not Available

    1991-09-01

    Radioactive waste is mounting at U.S. nuclear power plants at a rate of more than 2,000 metric tons a year. Pursuant to statute and anticipating that a geologic repository would be available in 1998, the Department of Energy (DOE) entered into disposal contracts with nuclear utilities. Now, however, DOE does not expect the repository to be ready before 2010. For this reason, DOE does not want to develop a facility for monitored retrievable storage (MRS) by 1998. This book is concerned about how best to store the waste until a repository is available, congressional requesters asked GAO to review the alternatives of continued storage at utilities' reactor sites or transferring waste to an MRS facility, GAO assessed the likelihood of an MRSA facility operating by 1998, legal implications if DOE is not able to take delivery of wastes in 1998, propriety of using the Nuclear Waste Fund-from which DOE's waste program costs are paid-to pay utilities for on-site storage capacity added after 1998, ability of utilities to store their waste on-site until a repository is operating, and relative costs and safety of the two storage alternatives.

  7. Institute for Nuclear Theory annual report No. 2, 1 March 1991--29 February 1992

    SciTech Connect

    Haxton, W.; Henley, E. M.

    1992-01-01

    This report discusses research on the following topics in Nuclear physics: electromagnetic interactions and few-nucleon systems; N*'s and nucleon structure; mesons and fields in nuclei; and nuclear astrophysics of type II supernovae. (LSP).

  8. Nuclear photonics

    NASA Astrophysics Data System (ADS)

    Habs, D.; Günther, M. M.; Jentschel, M.; Thirolf, P. G.

    2012-07-01

    With the planned new γ-beam facilities like MEGa-ray at LLNL (USA) or ELI-NP at Bucharest (Romania) with 1013 γ/s and a band width of ΔEγ/Eγ≈10-3, a new era of γ beams with energies up to 20MeV comes into operation, compared to the present world-leading HIγS facility at Duke University (USA) with 108 γ/s and ΔEγ/Eγ≈3ṡ10-2. In the long run even a seeded quantum FEL for γ beams may become possible, with much higher brilliance and spectral flux. At the same time new exciting possibilities open up for focused γ beams. Here we describe a new experiment at the γ beam of the ILL reactor (Grenoble, France), where we observed for the first time that the index of refraction for γ beams is determined by virtual pair creation. Using a combination of refractive and reflective optics, efficient monochromators for γ beams are being developed. Thus, we have to optimize the total system: the γ-beam facility, the γ-beam optics and γ detectors. We can trade γ intensity for band width, going down to ΔEγ/Eγ≈10-6 and address individual nuclear levels. The term "nuclear photonics" stresses the importance of nuclear applications. We can address with γ-beams individual nuclear isotopes and not just elements like with X-ray beams. Compared to X rays, γ beams can penetrate much deeper into big samples like radioactive waste barrels, motors or batteries. We can perform tomography and microscopy studies by focusing down to μm resolution using Nuclear Resonance Fluorescence (NRF) for detection with eV resolution and high spatial resolution at the same time. We discuss the dominating M1 and E1 excitations like the scissors mode, two-phonon quadrupole octupole excitations, pygmy dipole excitations or giant dipole excitations under the new facet of applications. We find many new applications in biomedicine, green energy, radioactive waste management or homeland security. Also more brilliant secondary beams of neutrons and positrons can be produced.

  9. Nuclear photonics

    SciTech Connect

    Habs, D.; Guenther, M. M.; Jentschel, M.; Thirolf, P. G.

    2012-07-09

    With the planned new {gamma}-beam facilities like MEGa-ray at LLNL (USA) or ELI-NP at Bucharest (Romania) with 10{sup 13}{gamma}/s and a band width of {Delta}E{gamma}/E{gamma} Almost-Equal-To 10{sup -3}, a new era of {gamma} beams with energies up to 20MeV comes into operation, compared to the present world-leading HI{gamma}S facility at Duke University (USA) with 10{sup 8}{gamma}/s and {Delta}E{gamma}/E{gamma} Almost-Equal-To 3 Dot-Operator 10{sup -2}. In the long run even a seeded quantum FEL for {gamma} beams may become possible, with much higher brilliance and spectral flux. At the same time new exciting possibilities open up for focused {gamma} beams. Here we describe a new experiment at the {gamma} beam of the ILL reactor (Grenoble, France), where we observed for the first time that the index of refraction for {gamma} beams is determined by virtual pair creation. Using a combination of refractive and reflective optics, efficient monochromators for {gamma} beams are being developed. Thus, we have to optimize the total system: the {gamma}-beam facility, the {gamma}-beam optics and {gamma} detectors. We can trade {gamma} intensity for band width, going down to {Delta}E{gamma}/E{gamma} Almost-Equal-To 10{sup -6} and address individual nuclear levels. The term 'nuclear photonics' stresses the importance of nuclear applications. We can address with {gamma}-beams individual nuclear isotopes and not just elements like with X-ray beams. Compared to X rays, {gamma} beams can penetrate much deeper into big samples like radioactive waste barrels, motors or batteries. We can perform tomography and microscopy studies by focusing down to {mu}m resolution using Nuclear Resonance Fluorescence (NRF) for detection with eV resolution and high spatial resolution at the same time. We discuss the dominating M1 and E1 excitations like the scissors mode, two-phonon quadrupole octupole excitations, pygmy dipole excitations or giant dipole excitations under the new facet of

  10. Tech Area II: A history

    SciTech Connect

    Ullrich, R.

    1998-07-01

    This report documents the history of the major buildings in Sandia National Laboratories` Technical Area II. It was prepared in support of the Department of Energy`s compliance with Section 106 of the National Historic Preservation Act. Technical Area II was designed and constructed in 1948 specifically for the final assembly of the non-nuclear components of nuclear weapons, and was the primary site conducting such assembly until 1952. Both the architecture and location of the oldest buildings in the area reflect their original purpose. Assembly activities continued in Area II from 1952 to 1957, but the major responsibility for this work shifted to other sites in the Atomic Energy Commission`s integrated contractor complex. Gradually, additional buildings were constructed and the original buildings were modified. After 1960, the Area`s primary purpose was the research and testing of high-explosive components for nuclear weapons. In 1994, Sandia constructed new facilities for work on high-explosive components outside of the original Area II diamond-shaped parcel. Most of the buildings in the area are vacant and Sandia has no plans to use them. They are proposed for decontamination and demolition as funding becomes available.

  11. Childhood leukemia around nuclear facilities.

    PubMed

    Hatch, M

    1992-12-15

    Epidemiologic studies on the health effects of living near nuclear facilities have been rare and, indeed, radiobiological models would not predict any detectable increase in cancer risk to the general public from the very low levels of radioactivity emitted by nuclear installations. Thus the recent evidence suggesting an excess of childhood leukemias in the vicinity of certain nuclear sites in the United Kingdom has generated considerable controversy. To help resolve the uncertainty and enhance interpretability of results, future epidemiologic studies will need to be designed with great care (and within realistic cost limits). This commentary suggests three areas for methodologic consideration: (i) definition and modelling of radiation exposure; (ii) selection of cancer sites and sensitive subgroups; and (iii) use of incidence or mortality data. Specific suggestions for further epidemiologic research are offered as well.

  12. Fifty years with nuclear fission

    SciTech Connect

    Behrens, J.W.; Carlson, A.D. )

    1989-01-01

    The news of the discovery of nucler fission, by Otto Hahn and Fritz Strassmann in Germany, was brought to the United States by Niels Bohr in January 1939. Since its discovery, the United States, and the world for that matter, has never been the same. It therefore seemed appropriate to acknowledge the fiftieth anniversary of its discovery by holding a topical meeting entitled, Fifty years with nuclear fission,'' in the United States during the year 1989. The objective of the meeting was to bring together pioneers of the nuclear industry and other scientists and engineers to report on reminiscences of the past and on the more recent developments in fission science and technology. The conference highlighted the early pioneers of the nuclear industry by dedicating a full day (April 26), consisting of two plenary sessions, at the National Academy of Sciences (NAS) in Washington, DC. More recent developments in fission science and technology in addition to historical reflections were topics for two full days of sessions (April 27 and 28) at the main sites of the NIST in Gaithersburg, Maryland. The wide range of topics covered by Volume 2 of this topical meeting included plenary invited, and contributed sessions entitled, Nuclear fission -- a prospective; reactors II; fission science II; medical and industrial applications by by-products; reactors and safeguards; general research, instrumentation, and by-products; and fission data, astrophysics, and space applications. The individual papers have been cataloged separately.

  13. The Nuclear Education and Staffing Challenge: Rebuilding Critical Skills in Nuclear Science and Technology

    SciTech Connect

    Wogman, Ned A.; Bond, Leonard J.; Waltar, Alan E.; Leber, R E.

    2005-01-01

    The United States, the Department of Energy (DOE) and its National Laboratories, including the Pacific Northwest National Laboratory (PNNL), are facing a serious attrition of nuclear scientists and engineers and their capabilities through the effects of aging staff. Within the DOE laboratories, 75% of nuclear personnel will be eligible to retire by 2010. It is expected that there will be a significant loss of senior nuclear science and technology staff at PNNL within five years. PNNL's nuclear legacy is firmly rooted in the DOE Hanford site, the World War II Manhattan Project, and subsequent programs. Historically, PNNL was a laboratory were 70% of its activities were nuclear/radiological, and now just under 50% of its current business science and technology are nuclear and radiologically oriented. Programs in the areas of Nuclear Legacies, Global Security, Nonproliferation, Homeland Security and National Defense, Radiobiology and Nuclear Energy still involve more than 1,000 of the 3,800 current laboratory staff, and these include more than 420 staff who are certified as nuclear/radiological scientists and engineers. This paper presents the current challenges faced by PNNL that require an emerging strategy to solve the nuclear staffing issues through the maintenance and replenishment of the human nuclear capital needed to support PNNL nuclear science and technology programs.

  14. The Nuclear Education and Staffing Challenge: Rebuilding Critical Skills in Nuclear Science and Technology.

    SciTech Connect

    Wogman, Ned A.; Bond, Leonard J.; Waltar, Alan E.; Leber, R. E.

    2005-01-01

    The United States, the Department of Energy (DOE) and its National Laboratories, including the Pacific Northwest National Laboratory (PNNL), are facing a serious attrition of nuclear scientists and engineers and their capabilities through the effects of aging staff. Within the DOE laboratories, 75% of nuclear personnel will be eligible to retire by 2010. It is expected that there will be a significant loss of senior nuclear science and technology staff at PNNL within five years. PNNL's nuclear legacy is firmly rooted in the DOE Hanford site, the World War II Manhattan Project, and subsequent programs. Historically, PNNL was a laboratory where 70% of its activities were nuclear/radiological, and now just under 50% of its current business science and technology are nuclear and radiologically oriented. Programs in the areas of Nuclear Legacies, Global Security, Nonproliferation, Homeland Security and National Defense, Radiobiology and Nuclear Energy still involve more than 1,000 of the 3,800 current laboratory staff, and these include more than 420 staff who are certified as nuclear/radiological scientists and engineers. This paper presents the current challenges faced by PNNL that require an emerging strategy to solve the nuclear staffing issues through the maintenance and replenishment of the human nuclear capital needed to support PNNL nuclear science and technology programs.

  15. Nuclear eclectic power.

    PubMed

    Rose, D J

    1974-04-19

    The uranium and thorium resources, the technology, and the social impacts all seem to presage an even sharper increase in nuclear power for electric generation than had hitherto been predicted. There are more future consequences. The "hydrogen economy." Nuclear power plants operate best at constant power and full load. Thus, a largely nuclear electric economy has the problem of utilizing substantial off-peak capacity; the additional energy generation can typically be half the normal daily demand. Thus, the option of generating hydrogen as a nonpolluting fuel receives two boosts: excess nuclear capacity to produce it, plus much higher future costs for oil and natural gas. However, the so-called "hydrogen economy" must await the excess capacity, which will not occur until the end of the century. Nonelectric uses. By analyses similar to those performed here, raw nuclear heat can be shown to be cheaper than heat from many other fuel sources, especially nonpolluting ones. This will be particularly true as domestic natural gas supplies become more scarce. Nuclear heat becomes attractive for industrial purposes, and even for urban district heating, provided (i) the temperature is high enough (this is no problem for district heating, but could be for industry; the HTGR's and breeders, with 600 degrees C or more available, have the advantage); (ii) there is a market for large quantities (a heat rate of 3800 Mw thermal, the reactor size permitted today, will heat Boston, with some to spare); and (iii) the social costs become more definitely resolved in favor of nuclear power. Capital requirements. Nuclear-electric installations are very capital-intensive. One trillion dollars for the plants, backup industry, and so forth is only 2 percent of the total gross national product (GNP) between 1974 and 2000, at a growth rate of 4 percent per year. But capital accumulation tends to run at about 10 percent of the GNP, so the nuclear requirements make a sizable perturbation. Also

  16. Photosystem II

    ScienceCinema

    James Barber

    2016-07-12

    James Barber, Ernst Chain Professor of Biochemistry at Imperial College, London, gives a BSA Distinguished Lecture titled, "The Structure and Function of Photosystem II: The Water-Splitting Enzyme of Photosynthesis."

  17. Russian nuclear-powered submarine decommissioning

    SciTech Connect

    Bukharin, O.; Handler, J.

    1995-11-01

    Russia is facing technical, economic and organizational difficulties in dismantling its oversized and unsafe fleet of nuclear powered submarines. The inability of Russia to deal effectively with the submarine decommissioning crisis increases the risk of environmental disaster and may hamper the implementation of the START I and START II treaties. This paper discusses the nuclear fleet support infrastructure, the problems of submarine decommissioning, and recommends international cooperation in addressing these problems.

  18. The second coming of the nuclear age

    SciTech Connect

    Ikle, F.C.

    1996-01-01

    Nuclear weapons were used for the first and only time in World War II, and the world has grown accustomed to their nonuse. But the overwhelming deterrent forces that worked during the Cold War will not provide protection against the new threats: terrorism and catastrophic accident. The arsenals and mindsets of the past half-century present a formidable barrier to change, but the United States must lead the way in preventing nuclear weapons from becoming acceptable.

  19. The Common Sense of Small Nuclear Arsenals

    DTIC Science & Technology

    2012-01-01

    reasons, France developed a small, independent nuclear arsenal after World War II. 4 It kept its force levels comparatively low, even during the Cold War...00-00-2012 to 00-00-2012 4 . TITLE AND SUBTITLE The Common Sense of Small Nuclear Arsenals 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...survival motive” is law-like. All human conduct is shaped in some measure by what individuals believe to be general laws. In science , laws establish

  20. The Nuclear Power and Nuclear Weapons Connection.

    ERIC Educational Resources Information Center

    Leventhal, Paul

    1990-01-01

    Explains problems enforcing the Nuclear Non-Proliferation Treaty (NPT) of 1968. Provides factual charts and details concerning the production of nuclear energy and arms, the processing and disposal of waste products, and outlines the nuclear fuel cycle. Discusses safeguards, the risk of nuclear terrorism, and ways to deal with these problems. (NL)

  1. The Nuclear Power/Nuclear Weapons Connection.

    ERIC Educational Resources Information Center

    Totten, Sam; Totten, Martha Wescoat

    1985-01-01

    Once they have nuclear power, most countries will divert nuclear materials from commercial to military programs. In excerpts from the book "Facing the Danger" (by Totten, S. and M. W., Crossing Press, 1984), five anti-nuclear activists explain how and why they have been addressing the nuclear connection. (RM)

  2. Nuclear energy.

    PubMed

    Grandin, Karl; Jagers, Peter; Kullander, Sven

    2010-01-01

    Nuclear energy can play a role in carbon free production of electrical energy, thus making it interesting for tomorrow's energy mix. However, several issues have to be addressed. In fission technology, the design of so-called fourth generation reactors show great promise, in particular in addressing materials efficiency and safety issues. If successfully developed, such reactors may have an important and sustainable part in future energy production. Working fusion reactors may be even more materials efficient and environmental friendly, but also need more development and research. The roadmap for development of fourth generation fission and fusion reactors, therefore, asks for attention and research in these fields must be strengthened.

  3. NUCLEAR REACTORS

    DOEpatents

    Long, E.; Ashley, J.W.

    1958-12-16

    A graphite moderator structure is described for a gas-cooled nuclear reactor having a vertical orlentation wherein the structure is physically stable with regard to dlmensional changes due to Wigner growth properties of the graphite, and leakage of coolant gas along spaces in the structure is reduced. The structure is comprised of stacks of unlform right prismatic graphite blocks positioned in layers extending in the direction of the lengths of the blocks, the adjacent end faces of the blocks being separated by pairs of tiles. The blocks and tiles have central bores which are in alignment when assembled and are provided with cooperatlng keys and keyways for physical stability.

  4. Nuclear security

    SciTech Connect

    Dingell, J.D.

    1991-02-01

    The Department of Energy's (DOE) Lawrence Livermore National Laboratory, located in Livermore, California, generates and controls large numbers of classified documents associated with the research and testing of nuclear weapons. Concern has been raised about the potential for espionage at the laboratory and the national security implications of classified documents being stolen. This paper determines the extent of missing classified documents at the laboratory and assesses the adequacy of accountability over classified documents in the laboratory's custody. Audit coverage was limited to the approximately 600,000 secret documents in the laboratory's custody. The adequacy of DOE's oversight of the laboratory's secret document control program was also assessed.

  5. Nuclear dualism.

    PubMed

    Karrer, Kathleen M

    2012-01-01

    Nuclear dualism is a characteristic feature of the ciliated protozoa. Tetrahymena have two different nuclei in each cell. The larger, polyploid, somatic macronucleus (MAC) is the site of transcriptional activity in the vegetatively growing cell. The smaller, diploid micronucleus (MIC) is transcriptionally inactive in vegetative cells, but is transcriptionally active in mating cells and responsible for the genetic continuity during sexual reproduction. Although the MICs and MACs develop from mitotic products of a common progenitor and reside in a common cytoplasm, they are different from one another in almost every respect.

  6. Condensed Matter Nuclear Science

    NASA Astrophysics Data System (ADS)

    Biberian, Jean-Paul

    2006-02-01

    . Bloch ions / T. A. Chubb. II. Inhibited diffusion driven surface transmutations / T. A. Chubb. III. Bloch nuclides, Iwamura transmutations, and Oriani showers / T. A. Chubb. Bose-Einstein condensate. Theoretical study of nuclear reactions induced by Bose-Einstein condensation in Pd / K.-I. Tsuchiya and H. Okumura. Proposal for new experimental tests of the Bose-Einstein condensation mechanism for low-energy nuclear reaction and transmutation processes in deuterium loaded micro- and nano-scale cavities / Y. E. Kim ... [et al.]. Mixtures of charged bosons confined in harmonic traps and Bose-Einstein condensation mechanism for low-energy nuclear reactions and transmutation processes in condensed matters / Y. E. Kim and A. L. Zubarev. Alternative interpretation of low-energy nuclear reaction processes with deuterated metals based on the Bose-Einstein condensation mechanism / Y. E. Kim and T. O. Passell. Multi-body fusion. [symbol]He/[symbol]He production ratios by tetrahedral symmetric condensation / A. Takahashi. Phonon coupling. Phonon-exchange models: some new results / P. L. Hagelstein. Neutron clusters. Cold fusion phenomenon and solid state nuclear physics / H. Kozima. Neutrinos, magnetic monopoles. Neutrino-driven nuclear reactions of cold fusion and transmutation / V. Filimonov. Light monopoles theory: an overview of their effects in physics, chemistry, biology, and nuclear science (weak interactions) / G. Lochak. Electrons clusters and magnetic monopoles / M. Rambaut. Others. Effects of atomic electrons on nuclear stability and radioactive decay / D. V. Filippov, L. I. Urutskoev, and A. A. Rukhadze. Search for erzion nuclear catalysis chains from cosmic ray erzions stopping in organic scintillator / Yu. N. Bazhutov and E. V. Pletnikov. Low-energy nuclear reactions resulting as picometer interactions with similarity to K-shell electron capture / H. Hora ... [et al.] -- 5. Other topics. On the possible magnetic mechanism of shortening the runaway of RBMK-1000 reactor

  7. Chemical Approaches to Nuclear Receptors in Metabolism

    PubMed Central

    Margolis, Ronald N.; Moore, David D.; Willson, Timothy M.; Guy, R. Kip

    2017-01-01

    The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsored a workshop, “Chemical Approaches to Nuclear Receptors and Metabolism,” in April 2009 to explore how chemical and molecular biology and physiology can be exploited to further our understanding of nuclear receptor structure, function, and role in disease. Signaling cascades involving nuclear receptors are more complex and interrelated than once thought. Nuclear receptors continue to be attractive targets for drug discovery. The overall goal of this workshop was to identify gaps in our understanding of the complexity of ligand activities and begin to address them by (i) increasing the collaboration of investigators from different disciplines, (ii) developing a better understanding of chemical modulation of nuclear receptor action, and (iii) identifying opportunities and roadblocks in the path of translating basic research to discovery of new therapeutics. PMID:19654413

  8. Nuclear weapons databook. Volume V: British, French, and Chinese nuclear weapons

    SciTech Connect

    Norris, R.S.; Burrows, A.S.; Fieldhouse, R.W.

    1994-12-31

    How insecurity and the search military independence drove post World War II nuclear proliferation beyond the United States and the Soviet Union is the subject of the latest and most voluminous title in the Natural Resources Defense Council`s highly acclaimed Nuclear Weapons Databook series. Volume 5 explains how atomic and thermonuclear weapons spread to Britain, France, and China despite the political turmoil and economic hardship that beset these countries. The history of the British nuclear weapons program includes the most comprehensive collection of photos and specifications of British warheads and nuclear tests ever assembled in one publication. The role of the United States in the French nuclear weapons program is discussed. This is a comprehensive source for the mechanics and politics of nuclear weapons proliferation.

  9. NUCLEAR REACTOR

    DOEpatents

    Miller, H.I.; Smith, R.C.

    1958-01-21

    This patent relates to nuclear reactors of the type which use a liquid fuel, such as a solution of uranyl sulfate in ordinary water which acts as the moderator. The reactor is comprised of a spherical vessel having a diameter of about 12 inches substantially surrounded by a reflector of beryllium oxide. Conventionnl control rods and safety rods are operated in slots in the reflector outside the vessel to control the operation of the reactor. An additional means for increasing the safety factor of the reactor by raising the ratio of delayed neutrons to prompt neutrons, is provided and consists of a soluble sulfate salt of beryllium dissolved in the liquid fuel in the proper proportion to obtain the result desired.

  10. NUCLEAR REACTOR

    DOEpatents

    Christy, R.F.

    1958-07-15

    A nuclear reactor of the homogeneous liquid fuel type is described wherein the fissionable isotope is suspended or dissolved in a liquid moderator such as water. The reactor core is comprised essentially of a spherical vessel for containing the reactive composition surrounded by a reflector, preferably of beryllium oxide. The reactive composition may be an ordinary water solution of a soluble salt of uranium, the quantity of fissionable isotope in solution being sufficient to provide a critical mass in the vessel. The liquid fuel is stored in a tank of non-crtttcal geometry below the reactor vessel and outside of the reflector and is passed from the tank to the vessel through a pipe connecting the two by air pressure means. Neutron absorbing control and safety rods are operated within slots in the reflector adjacent to the vessel.

  11. NUCLEAR REACTOR

    DOEpatents

    Grebe, J.J.

    1959-12-15

    A reactor which is particularly adapted tu serve as a heat source for a nuclear powered alrcraft or rocket is described. The core of this reactor consists of a porous refractory modera;or body which is impregnated with fissionable nuclei. The core is designed so that its surface forms tapered inlet and outlet ducts which are separated by the porous moderator body. In operation a gaseous working fluid is circulated through the inlet ducts to the surface of the moderator, enters and passes through the porous body, and is heated therein. The hot gas emerges into the outlet ducts and is available to provide thrust. The principle advantage is that tremendous quantities of gas can be quickly heated without suffering an excessive pressure drop.

  12. Nuclear reactor

    DOEpatents

    Wade, Elman E.

    1979-01-01

    A nuclear reactor including two rotatable plugs and a positive top core holddown structure. The top core holddown structure is divided into two parts: a small core cover, and a large core cover. The small core cover, and the upper internals associated therewith, are attached to the small rotating plug, and the large core cover, with its associated upper internals, is attached to the large rotating plug. By so splitting the core holddown structures, under-the-plug refueling is accomplished without the necessity of enlarging the reactor pressure vessel to provide a storage space for the core holddown structure during refueling. Additionally, the small and large rotating plugs, and their associated core covers, are arranged such that the separation of the two core covers to permit rotation is accomplished without the installation of complex lifting mechanisms.

  13. Biosorption of Cu(II), Zn(II), Ni(II) and Pb(II) ions by cross-linked metal-imprinted chitosans with epichlorohydrin.

    PubMed

    Chen, Chia-Yun; Yang, Cheng-Yu; Chen, Arh-Hwang

    2011-03-01

    Cross-linked metal-imprinted chitosan microparticles were prepared from chitosan, using four metals (Cu(II), Zn(II), Ni(II), and Pb(II)) as templates, and epichlorohydrin as the cross-linker. The microparticles were characterized by Fourier transform infrared spectroscopy, solid state (13)C nuclear magnetic resonance spectroscopy, and energy-dispersive X-ray spectroscopy. They were used for comparative biosorption of Cu(II), Zn(II), Ni(II) and Pb(II) ions in an aqueous solution. The results showed that the sorption capacities of Cu(II), Zn(II), Ni(II), and Pb(II) on the templated microparticles increased from 25 to 74%, 13 to 46%, 41 to 57%, and 12 to 43%, respectively, as compared to the microparticles without metal ion templates. The dynamic study showed that the sorption process followed the second-order kinetic equation. Three sorption models, Langmuir, Freundlich, and Dubinin-Radushkevich, were applied to the equilibrium isotherm data. The result showed that the Langmuir isotherm equation best fitted for monolayer sorption processes. Furthermore, the microparticles can be regenerated and reused for the metal removal.

  14. FAQs II

    ERIC Educational Resources Information Center

    Kezar, Adrianna; Frank, Vikki; Lester, Jaime; Yang, Hannah

    2008-01-01

    In their paper entitled "Why should postsecondary institutions consider partnering to offer (Individual Development Accounts (IDAs)?" the authors reviewed frequently asked questions they encountered from higher education professionals about IDAs, but as their research continued so did the questions. FAQ II has more in-depth questions and…

  15. SAGE II

    Atmospheric Science Data Center

    2016-02-16

    ... of stratospheric aerosols, ozone, nitrogen dioxide, water vapor and cloud occurrence by mapping vertical profiles and calculating ... (i.e. MLS and SAGE III versus HALOE) Fixed various bugs Details are in the  SAGE II V7.00 Release Notes .   ...

  16. Gamma II

    NASA Astrophysics Data System (ADS)

    Barker, Thurburn; Castelaz, M.; Cline, J.; Owen, L.; Boehme, J.; Rottler, L.; Whitworth, C.; Clavier, D.

    2011-05-01

    GAMMA II is the Guide Star Automatic Measuring MAchine relocated from STScI to the Astronomical Photographic Data Archive (APDA) at the Pisgah Astronomical Research Institute (PARI). GAMMA II is a multi-channel laser-scanning microdensitometer that was used to measure POSS and SERC plates to create the Guide Star Catalog and the Digital Sky Survey. The microdensitometer is designed with submicron accuracy in x and y measurements using a HP 5507 laser interferometer, 15 micron sampling, and the capability to measure plates as large as 0.5-m across. GAMMA II is a vital instrument for the success of digitizing the direct, objective prism, and spectra photographic plate collections in APDA for research. We plan several targeted projects. One is a collaboration with Drs. P.D. Hemenway and R. L. Duncombe who plan to scan 1000 plates of 34 minor planets to identify systematic errors in the Fundamental System of celestial coordinates. Another is a collaboration with Dr. R. Hudec (Astronomical Institute, Academy of Sciences of the Czech Republic) who is working within the Gaia Variability Unit CU7 to digitize objective prism spectra on the Henize plates and Burrell-Schmidt plates located in APDA. These low dispersion spectral plates provide optical counterparts of celestial high-energy sources and cataclysmic variables enabling the simulation of Gaia BP/RP outputs. The astronomical community is invited to explore the more than 140,000 plates from 20 observatories now archived in APDA, and use GAMMA II. The process of relocating GAMMA to APDA, re-commissioning, and starting up the production scan programs will be described. Also, we will present planned research and future upgrades to GAMMA II.

  17. Nuclear war: Opposing viewpoints

    SciTech Connect

    Szumski, B.

    1985-01-01

    This book presents opposing viewpoints on nuclear war. Topics discussed include: how nuclear would begin; would humanity survive; would civil defense work; will an arms agreement work; and can space weapons reduce the risk of nuclear war.

  18. Nuclear analytical chemistry

    SciTech Connect

    Brune, D.; Forkman, B.; Persson, B.

    1984-01-01

    This book covers the general theories and techniques of nuclear chemical analysis, directed at applications in analytical chemistry, nuclear medicine, radiophysics, agriculture, environmental sciences, geological exploration, industrial process control, etc. The main principles of nuclear physics and nuclear detection on which the analysis is based are briefly outlined. An attempt is made to emphasise the fundamentals of activation analysis, detection and activation methods, as well as their applications. The book provides guidance in analytical chemistry, agriculture, environmental and biomedical sciences, etc. The contents include: the nuclear periodic system; nuclear decay; nuclear reactions; nuclear radiation sources; interaction of radiation with matter; principles of radiation detectors; nuclear electronics; statistical methods and spectral analysis; methods of radiation detection; neutron activation analysis; charged particle activation analysis; photon activation analysis; sample preparation and chemical separation; nuclear chemical analysis in biological and medical research; the use of nuclear chemical analysis in the field of criminology; nuclear chemical analysis in environmental sciences, geology and mineral exploration; and radiation protection.

  19. Nuclear Quadrupole Moments and Nuclear Shell Structure

    DOE R&D Accomplishments Database

    Townes, C. H.; Foley, H. M.; Low, W.

    1950-06-23

    Describes a simple model, based on nuclear shell considerations, which leads to the proper behavior of known nuclear quadrupole moments, although predictions of the magnitudes of some quadrupole moments are seriously in error.

  20. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  1. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  2. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  3. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  4. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC...

  5. Nuclear South Asia

    DTIC Science & Technology

    2007-11-02

    inseparable from the history of nuclear developments in both India and Pakistan. The timing of India’s tests was determined by the pronuclear stance of the...Rawalpindi, 2001), 17-18. 53 3Robert Boardman, The Politics of Fading Dreams: Britain and the Nuclear Export Business, Nuclear Exports and World Politics (New...disasters of nuclear arms race. 61 BIBLIOGRAPHY Books Boardman, Robert. The Politics of Fading Dreams: Britain and the Nuclear Export Business, Nuclear

  6. Nuclear Fuel Cycle & Vulnerabilities

    SciTech Connect

    Boyer, Brian D.

    2012-06-18

    The objective of safeguards is the timely detection of diversion of significant quantities of nuclear material from peaceful nuclear activities to the manufacture of nuclear weapons or of other nuclear explosive devices or for purposes unknown, and deterrence of such diversion by the risk of early detection. The safeguards system should be designed to provide credible assurances that there has been no diversion of declared nuclear material and no undeclared nuclear material and activities.

  7. Nuclear reactor

    DOEpatents

    Thomson, Wallace B.

    2004-03-16

    A nuclear reactor comprising a cylindrical pressure vessel, an elongated annular core centrally disposed within and spaced from the pressure vessel, and a plurality of ducts disposed longitudinally of the pressure vessel about the periphery thereof, said core comprising an annular active portion, an annular reflector just inside the active portion, and an annular reflector just outside the active a portion, said annular active portion comprising rectangular slab, porous fuel elements radially disposed around the inner reflector and extending the length of the active portion, wedge-shaped, porous moderator elements disposed adjacent one face of each fuel element and extending the length of the fuel element, the fuel and moderator elements being oriented so that the fuel elements face each other and the moderator elements do likewise, adjacent moderator elements being spaced to provide air inlet channels, and adjacent fuel elements being spaced to provide air outlet channels which communicate with the interior of the peripheral ducts, and means for introducing air into the air inlet channels which passes through the porous moderator elements and porous fuel elements to the outlet channel.

  8. Nuclear Proliferation: A Global Nuclear Strategy

    DTIC Science & Technology

    2007-03-30

    thinking about nuclear weapons as a “ Wild Card ” in this case. Finally, just as North Korea is using nuclear weapons as a “bargaining chip,” we...definite disadvantage for non-nuclear nations not to have a nuclear” Wild Card ”. So some misguided Japanese politicians are attracted to the “ Wild Card ” advantage

  9. Nuclear weapons modernizations

    SciTech Connect

    Kristensen, Hans M.

    2014-05-09

    This article reviews the nuclear weapons modernization programs underway in the world's nine nuclear weapons states. It concludes that despite significant reductions in overall weapons inventories since the end of the Cold War, the pace of reductions is slowing - four of the nuclear weapons states are even increasing their arsenals, and all the nuclear weapons states are busy modernizing their remaining arsenals in what appears to be a dynamic and counterproductive nuclear competition. The author questions whether perpetual modernization combined with no specific plan for the elimination of nuclear weapons is consistent with the nuclear Non-Proliferation Treaty and concludes that new limits on nuclear modernizations are needed.

  10. Nuclear weapons modernizations

    NASA Astrophysics Data System (ADS)

    Kristensen, Hans M.

    2014-05-01

    This article reviews the nuclear weapons modernization programs underway in the world's nine nuclear weapons states. It concludes that despite significant reductions in overall weapons inventories since the end of the Cold War, the pace of reductions is slowing - four of the nuclear weapons states are even increasing their arsenals, and all the nuclear weapons states are busy modernizing their remaining arsenals in what appears to be a dynamic and counterproductive nuclear competition. The author questions whether perpetual modernization combined with no specific plan for the elimination of nuclear weapons is consistent with the nuclear Non-Proliferation Treaty and concludes that new limits on nuclear modernizations are needed.

  11. Who Should Control Nuclear Technology? A Curriculum Unit for Contemporary U.S. and World History, Grades 9-12.

    ERIC Educational Resources Information Center

    Zimney, Michelle; Boston, Jane

    Since the end of World War II and the onset of the "new age," nuclear technology has remained high on the world's agenda as questions regarding sovereignty and the balance of power, control of the development and spread of nuclear weapons, non-military uses for nuclear technology, and nuclear safety are debated among and within nations.…

  12. Nuclear and Radiochemistry: the First 100 Years

    NASA Astrophysics Data System (ADS)

    Friedlander, G.; Herrmann, G.

    This chapter gives a brief overview of the development of nuclear and radiochemistry from Mme. Curie's chemical isolation of radium toward the end of the twentieth century. The first four sections deal with fairly distinct time periods: (1) the pioneering years when the only radioactive materials available were the naturally occurring ones; (2) the decade of rapid growth and expansion of both the fundamental science and its applications following the discoveries of the neutron and artificial radioactivity; (3) the World War II period characterized by the intense exploration of nuclear fission and its ramifications; (4) what can be called the “golden era” - the 3 to 4 decades following World War II when nuclear science was generously supported and therefore flourished. In the final section, research trends pursued near the end of the century are briefly touched upon.

  13. Consequences of Regional Scale Nuclear Conflicts and Acts of Individual Nuclear Terrorism

    NASA Astrophysics Data System (ADS)

    Toon, O. B.; Turco, R. P.; Robock, A.; Bardeen, C.; Oman, L.; Stenchikov, G. L.

    2006-12-01

    The number of nuclear warheads in the world has fallen by about a factor of three since its peak in 1986. However, the potential exists for numerous regional nuclear arms races, and for a significant expansion in the number of nuclear weapons states. Eight countries are known to have nuclear weapons, 2 are constructing them, and an additional 32 nations already have the fissile material needed to build weapons if they so desire. Population and economic activity worldwide are congregated to an increasing extent in "megacities", which are ideal targets for nuclear weapons. We find that low yield weapons, which new nuclear powers are likely to construct, can produce 100 times as many fatalities and 100 times as much smoke from fires per kt yield as high-yield weapons, if they are targeted at city centers. A single low-yield nuclear detonation in an urban center could lead to more fatalities, in some cases by orders of magnitude, than have occurred in major historical conflicts. A regional war between the smallest current nuclear states involving 100 15-kt explosions (less than 0.1% of the explosive yield of the current global nuclear arsenal) could produce direct fatalities comparable to all of those worldwide in World War II (WW-II), or to those once estimated for a "counterforce" nuclear war between the superpowers. Portions of megacities attacked with nuclear devices or exposed to fallout of long-lived isotopes, through armed conflict or terrorism, would likely be abandoned indefinitely, with severe national and international implications. Smoke from urban firestorms in a regional war might induce significant climatic and ozone anomalies on global scales. While there are many uncertainties in the issues we discuss here, the major uncertainties are the type and scale of conflict that might occur. Each of these potential hazards deserves careful analysis by governments worldwide advised by a broad section of the world scientific community, as well as widespread

  14. Data trimming, nuclear emissions, and climate change.

    PubMed

    Shrader-Frechette, Kristin Sharon

    2009-03-01

    Ethics requires good science. Many scientists, government leaders, and industry representatives support tripling of global-nuclear-energy capacity on the grounds that nuclear fission is "carbon free" and "releases no greenhouse gases." However, such claims are scientifically questionable (and thus likely to lead to ethically questionable energy choices) for at least 3 reasons. (i) They rely on trimming the data on nuclear greenhouse-gas emissions (GHGE), perhaps in part because flawed Kyoto Protocol conventions require no full nuclear-fuel-cycle assessment of carbon content. (ii) They underestimate nuclear-fuel-cycle releases by erroneously assuming that mostly high-grade uranium ore, with much lower emissions, is used. (iii) They inconsistently compare nuclear-related GHGE only to those from fossil fuels, rather than to those from the best GHG-avoiding energy technologies. Once scientists take account of (i)-(iii), it is possible to show that although the nuclear fuel cycle releases (per kWh) much fewer GHG than coal and oil, nevertheless it releases far more GHG than wind and solar-photovoltaic. Although there may be other, ethical, reasons to support nuclear tripling, reducing or avoiding GHG does not appear to be one of them.

  15. PORT II

    NASA Technical Reports Server (NTRS)

    Muniz, Beau

    2009-01-01

    One unique project that the Prototype lab worked on was PORT I (Post-landing Orion Recovery Test). PORT is designed to test and develop the system and components needed to recover the Orion capsule once it splashes down in the ocean. PORT II is designated as a follow up to PORT I that will utilize a mock up pressure vessel that is spatially compar able to the final Orion capsule.

  16. Nuclear power for Mars surface

    SciTech Connect

    Houts, M.G.; Buksa, J.J.; Howe, S.D.

    1993-01-01

    Safe, reliable, low-mass, low-volume, long-life nuclear fission power supplies are an attractive option for meeting lunar and Martian surface power requirements. Two factors will have a strong impact on the suitability of a surface nuclear power supply: the technology used by the reactor and the overall system mass. Because thermionic technology is well suited for surface applications, this paper briefly discusses the existing 6 kWe Russian TOPAZ II reactor and two near-term US thermionic space nuclear power supplies capable of providing 40 kWe. Man-rated shielding will be a significant fraction of the mass of any surface nuclear fission power supply. Because of the importance of optimizing the reactor shield, this paper presents detailed calculations related to the shielding properties of lunar and Martian soil, and the effectiveness of using existing craters to shield a reactor. Preliminary results indicate that it may be desirable to incorporate neutron shielding into the reactor design, but when possible in-situ materials should be used. Preliminary calculations also indicate that while existing craters could provide substantial shielding, radiation scatter off of the crater rim may limit the overall shielding effectiveness of the crater. 7 refs.

  17. Nuclear Power in China

    NASA Astrophysics Data System (ADS)

    Zhou, Yun

    2012-02-01

    In response to the Fukushima accident, China is strengthening its nuclear safety at reactors in operation, under construction and in preparation, including efforts to improve nuclear safety regulations and guidelines based on lessons learned from the accident. Although China is one of the major contributors in the global nuclear expansion, China's nuclear power industry is relatively young. Its nuclear safety regulators are less experienced compared to those in other major nuclear power countries. To realize China's resolute commitment to rapid growth of safe nuclear energy, detailed analyses of its nuclear safety regulatory system are required. This talk explains China's nuclear energy program and policy at first. It also explores China's governmental activities and future nuclear development after Fukushima accidents. At last, an overview of China's nuclear safety regulations and practices are provided. Issues and challenges are also identified for police makers, regulators, and industry professionals.

  18. Recent developments in Topaz II reactor safety assessments

    SciTech Connect

    Marshall, A.C.

    1993-07-01

    In December 1991, the Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of a US launch of a Russian Topaz II space nuclear power system. The primary mission goal would be to demonstrate and evaluate Nuclear Electric Propulsion technology to establish a capability for future civilian and military missions. A preliminary nuclear safety assessment, involving selected safety analyses, was initiated to determine whether or not a space mission could be conducted safely and within budget constraints. This paper describes the preliminary safety assessment results and the nuclear safety program now being established for the Nuclear Electric Propulsion Space Test Program (NEPSTP).

  19. Nuclear reactor

    DOEpatents

    Pennell, William E.; Rowan, William J.

    1977-01-01

    A nuclear reactor in which the core components, including fuel-rod assemblies, control-rod assemblies, fertile rod-assemblies, and removable shielding assemblies, are supported by a plurality of separate inlet modular units. These units are referred to as inlet module units to distinguish them from the modules of the upper internals of the reactor. The modular units are supported, each removable independently of the others, in liners in the supporting structure for the lower internals of the reactor. The core assemblies are removably supported in integral receptacles or sockets of the modular units. The liners, units, sockets and assmblies have inlet openings for entry of the fluid. The modular units are each removably mounted in the liners with fluid seals interposed between the opening in the liner and inlet module into which the fluid enters and the upper and lower portion of the liner. Each assembly is similarly mounted in a corresponding receptacle with fluid seals interposed between the openings where the fluid enters and the lower portion of the receptacle or fitting closely in these regions. As fluid flows along each core assembly a pressure drop is produced along the fluid so that the fluid which emerges from each core assembly is at a lower pressure than the fluid which enters the core assembly. However because of the seals interposed in the mountings of the units and assemblies the pressures above and below the units and assemblies are balanced and the units are held in the liners and the assemblies are held in the receptacles by their weights as they have a higher specific gravity than the fluid. The low-pressure spaces between each module and its liner and between each core assembly and its module is vented to the low-pressure regions of the vessel to assure that fluid which leaks through the seals does not accumulate and destroy the hydraulic balance.

  20. Nuclear reactor

    DOEpatents

    Yant, Howard W.; Stinebiser, Karl W.; Anzur, Gregory C.

    1977-01-01

    A nuclear reactor, particularly a liquid-metal breeder reactor, whose upper internals include outlet modules for channeling the liquid-metal coolant from selected areas of the outlet of the core vertically to the outlet plenum. The modules are composed of a highly-refractory, high corrosion-resistant alloy, for example, INCONEL-718. Each module is disposed to confine and channel generally vertically the coolant emitted from a subplurality of core-component assemblies. Each module has a grid with openings, each opening disposed to receive the coolant from an assembly of the subplurality. The grid in addition serves as a holdown for the assemblies of the corresponding subplurality preventing their excessive ejection upwardly from the core. In the region directly over the core the outlet modules are of such peripheral form that they nest forming a continuum over the core-component assemblies whose outlet coolant they confine. Each subassembly includes a chimney which confines the coolant emitted by its corresponding subassemblies to generally vertical flow between the outlet of the core and the outlet plenum. Each subplurality of assemblies whose emitted coolant is confined by an outlet module includes assemblies which emit lower-temperature coolant, for example, a control-rod assembly, or fertile assemblies, and assemblies which emit coolant of substantially higher temperature, for example, fuel-rod assemblies. The coolants of different temperatures are mixed in the chimneys reducing the effect of stripping (hot-cold temperature fluctuations) on the remainder of the upper internals which are composed typically of AISI-304 or AISI-316 stainless steel.

  1. Virtual breakdown of the nuclear envelope in fission yeast meiosis.

    PubMed

    Asakawa, Haruhiko; Kojidani, Tomoko; Mori, Chie; Osakada, Hiroko; Sato, Mamiko; Ding, Da-Qiao; Hiraoka, Yasushi; Haraguchi, Tokuko

    2010-11-09

    Asymmetric localization of Ran regulators (RanGAP1 and RanGEF/RCC1) produces a gradient of RanGTP across the nuclear envelope. In higher eukaryotes, the nuclear envelope breaks down as the cell enters mitosis (designated "open" mitosis). This nuclear envelope breakdown (NEBD) leads to collapse of the RanGTP gradient and the diffusion of nuclear and cytoplasmic macromolecules in the cell, resulting in irreversible progression of the cell cycle. On the other hand, in many fungi, chromosome segregation takes place without NEBD (designated "closed" mitosis). Here we report that in the fission yeast Schizosaccharomyces pombe, despite the nuclear envelope and the nuclear pore complex remaining intact throughout both the meiotic and mitotic cell cycles, nuclear proteins diffuse into the cytoplasm transiently for a few minutes at the onset of anaphase of meiosis II. We also found that nuclear protein diffusion into the cytoplasm occurred coincidently with nuclear localization of Rna1, an S. pombe RanGAP1 homolog that is usually localized in the cytoplasm. These results suggest that nuclear localization of RanGAP1 and depression of RanGTP activity in the nucleus may be mechanistically tied to meiosis-specific diffusion of nuclear proteins into the cytoplasm. This nucleocytoplasmic shuffling of RanGAP1 and nuclear proteins represents virtual breakdown of the nuclear envelope.

  2. Perspectives of The Interagency Nuclear Safety Review Panel (INSRP) on future nuclear powered space missions

    SciTech Connect

    Gray, L.B. ); Pyatt, D.W. ); Sholtis, J.A. ); Winchester, R.O. , c/o Directorate of Nuclear Surety, Kirtland AFB, New Mexico 87117 )

    1993-01-10

    The Interagency Nuclear Safety Review Panel (INSRP) has provided reviews of all nuclear powered spacecraft launched by the United States. The two most recent launches were Ulysses in 1990 and Galileo in 1989. One reactor was launched in 1965 (SNAP-10A). All other U.S. space missions have utilized radioisotopic thermoelectric generators (RTGs). There are several missions in the next few years that are to be nuclear powered, including one that would utilize the Topaz II reactor purchased from Russia. INSRP must realign itself to perform parallel safety assessments of a reactor powered space mission, which has not been done in about thirty years, and RTG powered missions.

  3. The New Nuclear Nations.

    ERIC Educational Resources Information Center

    Spector, Leonard S.

    1990-01-01

    Explores the issue of nuclear proliferation, noting that the countries with nuclear capability now include Israel, South Africa, India, and Pakistan. Describes the role and problems of the United States in halting nuclearization. Supplies charts, maps, and information concerning the state of nuclear capability in each country. (NL)

  4. Nuclear air cushion vehicles

    NASA Technical Reports Server (NTRS)

    Anderson, J. L.

    1973-01-01

    The state-of-the-art of the still-conceptual nuclear air cushion vehicle, particularly the nuclear powerplant is identified. Using mission studies and cost estimates, some of the advantages of nuclear power for large air cushion vehicles are described. The technology studies on mobile nuclear powerplants and conceptual ACV systems/missions studies are summarized.

  5. Nuclear energy and security

    SciTech Connect

    BLEJWAS,THOMAS E.; SANDERS,THOMAS L.; EAGAN,ROBERT J.; BAKER,ARNOLD B.

    2000-01-01

    Nuclear power is an important and, the authors believe, essential component of a secure nuclear future. Although nuclear fuel cycles create materials that have some potential for use in nuclear weapons, with appropriate fuel cycles, nuclear power could reduce rather than increase real proliferation risk worldwide. Future fuel cycles could be designed to avoid plutonium production, generate minimal amounts of plutonium in proliferation-resistant amounts or configurations, and/or transparently and efficiently consume plutonium already created. Furthermore, a strong and viable US nuclear infrastructure, of which nuclear power is a large element, is essential if the US is to maintain a leadership or even participatory role in defining the global nuclear infrastructure and controlling the proliferation of nuclear weapons. By focusing on new fuel cycles and new reactor technologies, it is possible to advantageously burn and reduce nuclear materials that could be used for nuclear weapons rather than increase and/or dispose of these materials. Thus, the authors suggest that planners for a secure nuclear future use technology to design an ideal future. In this future, nuclear power creates large amounts of virtually atmospherically clean energy while significantly lowering the threat of proliferation through the thoughtful use, physical security, and agreed-upon transparency of nuclear materials. The authors must develop options for policy makers that bring them as close as practical to this ideal. Just as Atoms for Peace became the ideal for the first nuclear century, they see a potential nuclear future that contributes significantly to power for peace and prosperity.

  6. Terrorists and Nuclear Technology

    ERIC Educational Resources Information Center

    Krieger, David

    1975-01-01

    This essay explores the ways terrorist groups may gain possession of nuclear materials; the way in which they may use nuclear weapons and other nuclear technologies to their benefit; and various courses of action designed to minimize the possibilities of terrorists utilizing nuclear technology to their benefit and society's detriment. (BT)

  7. Frontiers of Nuclear Structure

    SciTech Connect

    Nazarewicz, Witold

    1997-12-31

    Current developments in nuclear structure at the `limits` are discussed. The studies of nuclear behavior at extreme conditions provide us with invaluable information about the nature of the nuclear interaction and nucleonic correlations at various energy-distance scales. In this talk frontiers of nuclear structure are briefly reviewed from a theoretical perspective, mainly concentrating on medium-mass and heavy nuclei.

  8. Nuclear medicine annual, 1984

    SciTech Connect

    Freeman, L.M.; Weissmann, H.S.

    1984-01-01

    The following topics are reviewed in this work: nuclear physicians role in planning for and handling radiation accidents; the role of nuclear medicine in evaluating the hypertensive patient; studies of the heart with radionuclides; role of radionuclide imaging in the patient undergoing chemotherapy; hematologic nuclear medicine; the role of nuclear medicine in sports related injuries; radionuclide evaluation of hepatic function with emphasis on cholestatis.

  9. A Conversation with William A. Fowler Part II

    NASA Astrophysics Data System (ADS)

    Greenberg, John

    2005-06-01

    Physicist William A.Fowler initiated an experimental program in nuclear astrophysics after World War II. He recalls here the Steady State versus Big Bang controversy and his celebrated collaboration with Fred Hoyle and Geoffrey and Margaret Burbidge on nucleosynthesis in stars. He also comments on the shift away from nuclear physics in universities to large accelerators and national laboratories.

  10. PESTICINS II. I and II

    PubMed Central

    Brubaker, Robert R.; Surgalla, Michael J.

    1962-01-01

    Brubaker, Robert R. (Fort Detrick, Frederick, Md.) and Michael J. Surgalla. Pesticins. II. Production of pesticin I and II. J. Bacteriol. 84:539–545. 1962.—Pesticin I was separated from pesticin I inhibitor by ion-exchange chromatography of cell-free culture supernatant fluids and by acid precipitation of soluble preparations obtained from mechanically disrupted cells. The latter procedure resulted in formation of an insoluble pesticin I complex which, upon removal by centrifugation and subsequent dissolution in neutral buffer, exhibited a 100- to 1,000-fold increase in antibacterial activity over that originally observed. However, activity returned to the former level upon addition of the acid-soluble fraction, which contained pesticin I inhibitor. Since the presence of pesticin I inhibitor leads to serious errors in the determination of pesticin I, an assay medium containing ethylenediaminetetraacetic acid in excess Ca++ was developed; this medium eliminated the effect of the inhibitor. By use of the above medium, sufficient pesticin I was found to be contained within 500 nonirradiated cells to inhibit growth of a suitable indicator strain; at least 107 cells were required to effect a corresponding inhibition by pesticin II. Although both pesticins are located primarily within the cell during growth, pesticin I may arise extracellularly during storage of static cells. Slightly higher activity of pesticin I inhibitor was found in culture supernatant fluids than occurred in corresponding cell extracts of equal volume. The differences and similarities between pesticin I and some known bacteriocins are discussed. PMID:14016110

  11. 78 FR 35989 - Tennessee Valley Authority; Watts Bar Nuclear Plant, Unit 2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ..., Maryland 20852. FOR FURTHER INFORMATION CONTACT: Elaine N. Keegan, Office of Nuclear Reactor Regulation, U... second light-water nuclear reactor (the facility), WBN Unit 2, located on the applicant's site in Rhea... Branch II-1, Division of Operating Reactor Licensing, Office of Nuclear Reactor Regulation. BILLING...

  12. Consideration of Initial Nuclear Radiation in an Attack on a Civilian Population

    DTIC Science & Technology

    1980-03-01

    4 2.Initial Nuclear Radiation. .. ................ 5 D. Thermal and Residual ?Fuclear Radiation ....... 9 E. Blast Casualties...Comparison of Distance and Explosive Yield for Blast, Thermal Radiation, and Components of the Initial Nuclear Radiation Field ..... ........... 15 II...several of the phenomena. Phenomena that occur promptly are air blast and ground shock, thermal radiation and heat, initial nuclear radiation, and

  13. Advanced nuclear precleaner

    SciTech Connect

    Wright, S.R.

    1997-10-01

    This Phase II Small Business Innovation Research (SBIR) program`s goal is to develop a dynamic, self-cleaning air precleaner for high-efficiency particulate air (HEPA) filtration systems that would extend significantly the life of HEPA filter banks by reducing the particulate matter that causes filter fouling and increased pack pressure. HEPA filters are widely used in DOE, Department of Defense, and a variety of commercial facilities. InnovaTech, Inc. (Formerly Micro Composite materials Corporation) has developed a proprietary dynamic separation device using a concept called Boundary Layer Momentum Transfer (BLMT) to extract particulate matter from fluid process streams. When used as a prefilter in the HVAC systems or downstream of waste vitrifiers in nuclear power plants, fuel processing facilities, and weapons decommissioning factories, the BLMT filter will dramatically extend the service life and increase the operation efficiency of existing HEPA filtration systems. The BLMT filter is self cleaning, so there will be no degraded flow or increased pressure drop. Because the BLMT filtration process is independent of temperature, it can be designed to work in ambient, medium, or high-temperature applications. During Phase II, the authors are continuing development of the computerized flow simulation model to include turbulence and incorporate expansion into a three-dimensional model that includes airflow behavior inside the filter housing before entering the active BLMT device. A full-scale (1000 ACFM) prototype filter is being designed to meet existing HEPA filter standards and will be fabricated for subsequent testing. Extensive in-house testing will be performed to determine a full range of performance characteristics. Final testing and evaluation of the prototype filter will be conducted at a DOE Quality Assurance Filter Test Station.

  14. The nuclear freeze controversy

    SciTech Connect

    Payne, K.B.; Gray, C.S.

    1984-01-01

    This book presents papers on nuclear arms control. Topics considered include the background and rationale behind the nuclear freeze proposal, nuclear deterrence, national defense, arms races, arms buildup, warfare, the moral aspects of nuclear deterrence, treaty verification, the federal budget, the economy, a historical perspective on Soviet policy toward the freeze, the other side of the Soviet peace offensive, and making sense of the nuclear freeze debate.

  15. Radon and Thoron Measured in Petrol and Gas-oil Exhaust Fumes by Using CR-39 and LR-115 II Nuclear Track Detectors: Radiation Doses to the Respiratory Tract of Mechanic Workers.

    PubMed

    Misdaq, M A; Chaouqi, A; Ouguidi, J; Touti, R; Mortassim, A

    2015-06-01

    Mechanic workers are exposed to exhaust fumes when controlling vehicle engines in motion inside repair shops. To assess radiation doses due to radon short-lived progeny from the inhalation of exhaust fumes by mechanic workers, concentrations of these radionuclides were measured in petrol (gasoline) and gas-oil exhaust fumes by evaluating mean critical angles of etching of the CR-39 and LR-115 type II SSNTDs for alpha particles emitted by the radon and thoron decay series. Committed effective doses due to ²¹⁸Po and ²¹⁴Po short-lived radon decay products from the inhalation of petrol and gas-oil exhaust fumes by workers were evaluated. A maximum value of 1.35 mSv y⁻¹ due to radon short-lived decay products from the inhalation of gas-oil exhaust fumes by mechanic workers was found, which is lower than the (3-10 mSv y⁻¹) dose limit interval for workers.

  16. Correlation of radioactive-waste-treatment costs and the environmental impact of waste effluents in the nuclear fuel cycle: conversion of yellow cake to uranium hexafluoride. Part II. The solvent extraction-fluorination process

    SciTech Connect

    Sears, M.B.; Etnier, E.L.; Hill, G.S.; Patton, B.D.; Witherspoon, J.P.; Yen, S.N.

    1983-03-01

    A cost/benefit study was made to determine the cost and effectiveness of radioactive waste (radwaste) treatment systems for decreasing the release of radioactive materials and chemicals from a model uranium hexafluoride (UF/sub 6/) production plant using the solvent extraction-fluorination process, and to evaluate the radiological impact (dose commitment) of the release materials on the environment. The model plant processes 10,000 metric tons of uranium per year. Base-case waste treatment is the minimum necessary to operate the process. Effluents meet the radiological requirements listed in the Code of Federal Regulations, Title 10, Part 20 (10 CFR 20), Appendix B, Table II, but may not be acceptable chemically at all sites. Additional radwaste treatment techniques are applied to the base-case plant in a series of case studies to decrease the amounts of radioactive materials released and to reduce the amounts of radioactive materials released and to reduce the radiological dose commitment to the population in the surrounding area. The costs for the added waste treatment operations and the corresponding dose committment are correlated with the annual cost for treatment of the radwastes. The status of the radwaste treatment methods used in the case studies is discussed. Much of the technology used in the advanced cases will require development and demonstration, or else is proprietary and unavailable for immediate use. The methodology and assumptions for the radiological doses are found in ORNL-4992.

  17. Extended Deterrence, Nuclear Proliferation, and START III

    SciTech Connect

    Speed, R.D.

    2000-06-20

    Early in the Cold War, the United States adopted a policy of ''extended nuclear deterrence'' to protect its allies by threatening a nuclear strike against any state that attacks these allies. This threat can (in principle) be used to try to deter an enemy attack using conventional weapons or one using nuclear, chemical, or biological weapons. The credibility of a nuclear threat has long been subject to debate and is dependent on many complex geopolitical factors, not the least of which is the military capabilities of the opposing sides. The ending of the Cold War has led to a significant decrease in the number of strategic nuclear weapons deployed by the United States and Russia. START II, which was recently ratified by the Russian Duma, will (if implemented) reduce the number deployed strategic nuclear weapons on each side to 3500, compared to a level of over 11,000 at the end of the Cold War in 1991. The tentative limit established by Presidents Clinton and Yeltsin for START III would reduce the strategic force level to 2000-2500. However, the Russians (along with a number of arms control advocates) now argue that the level should be reduced even further--to 1500 warheads or less. The conventional view is that ''deep cuts'' in nuclear weapons are necessary to discourage nuclear proliferation. Thus, as part of the bargain to get the non-nuclear states to agree to the renewal of the Nuclear Non-Proliferation Treaty, the United States pledged to work towards greater reductions in strategic forces. Without movement in the direction of deep cuts, it is thought by many analysts that some countries may decide to build their own nuclear weapons. Indeed, this was part of the rationale India used to justify its own nuclear weapons program. However, there is also some concern that deep cuts (to 1500 or lower) in the U.S. strategic nuclear arsenal could have the opposite effect. The fear is that such cuts might undermine extended deterrence and cause a crisis in confidence

  18. Nuclear Waste Disposal

    SciTech Connect

    Gee, Glendon W.; Meyer, Philip D.; Ward, Andy L.

    2005-01-12

    Nuclear wastes are by-products of nuclear weapons production and nuclear power generation, plus residuals of radioactive materials used by industry, medicine, agriculture, and academia. Their distinctive nature and potential hazard make nuclear wastes not only the most dangerous waste ever created by mankind, but also one of the most controversial and regulated with respect to disposal. Nuclear waste issues, related to uncertainties in geologic disposal and long-term protection, combined with potential misuse by terrorist groups, have created uneasiness and fear in the general public and remain stumbling blocks for further development of a nuclear industry in a world that may soon be facing a global energy crisis.

  19. Nuclear Security for Floating Nuclear Power Plants

    SciTech Connect

    Skiba, James M.; Scherer, Carolynn P.

    2015-10-13

    Recently there has been a lot of interest in small modular reactors. A specific type of these small modular reactors (SMR,) are marine based power plants called floating nuclear power plants (FNPP). These FNPPs are typically built by countries with extensive knowledge of nuclear energy, such as Russia, France, China and the US. These FNPPs are built in one country and then sent to countries in need of power and/or seawater desalination. Fifteen countries have expressed interest in acquiring such power stations. Some designs for such power stations are briefly summarized. Several different avenues for cooperation in FNPP technology are proposed, including IAEA nuclear security (i.e. safeguards), multilateral or bilateral agreements, and working with Russian design that incorporates nuclear safeguards for IAEA inspections in non-nuclear weapons states

  20. March to Armageddon: The United States and the nuclear arms race, 1939 to the present

    SciTech Connect

    Powaski, R.

    1987-01-01

    This history of the events, forces, and factors that have brought the world to the brink of nuclear holocaust probes two basic questions: what factors perpetuate the nuclear arms race and why is it so difficult to end. Starting with the opening days of World War II, this study traces the escalating arms race up to the present and notes that, while nuclear arsenals continue to grow, nuclear arms treaties are on the verge of collapse.

  1. The Topaz-II project: A technical teaming of US and Russian scientists

    SciTech Connect

    Thome, F.V.; Wyant, F.J.; Oglobin, B.

    1994-12-31

    This report describes research efforts associated with the Topaz-II project and thermionic conversion. The Thermionic System Evaluation test is a program that is executed by Air FOrce Phillips Laboratory and involves the purchase of two Russian TOPAZ II space nuclear power reactor systems and support equipment necessary for nonuclear ground testing. The laboratory also is involved with the The Nuclear Electric Propulsion Space Test Power System that involes the evaluation of the TOPAZ II system from a safety perspective.

  2. Rational serendipity: "undirected" synthesis of a large {MnCu} complex from pre-formed Mn(II) building blocks.

    PubMed

    Frost, Jamie M; Kettles, Fraser J; Wilson, Claire; Murrie, Mark

    2016-11-15

    Use of an aminopolyalcohol-based Mn(II) complex in solvothermal Cu(II) chemistry leads to a rare example of a high nuclearity heterometallic {MnCu} system, in which four Cu(II)(H1Edte) units trap an inner {MnCu(II)} oxide core.

  3. Nuclear radiation actuated valve

    DOEpatents

    Christiansen, David W.; Schively, Dixon P.

    1985-01-01

    A nuclear radiation actuated valve for a nuclear reactor. The valve has a valve first part (such as a valve rod with piston) and a valve second part (such as a valve tube surrounding the valve rod, with the valve tube having side slots surrounding the piston). Both valve parts have known nuclear radiation swelling characteristics. The valve's first part is positioned to receive nuclear radiation from the nuclear reactor's fuel region. The valve's second part is positioned so that its nuclear radiation induced swelling is different from that of the valve's first part. The valve's second part also is positioned so that the valve's first and second parts create a valve orifice which changes in size due to the different nuclear radiation caused swelling of the valve's first part compared to the valve's second part. The valve may be used in a nuclear reactor's core coolant system.

  4. RBC nuclear scan

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/003835.htm RBC nuclear scan To use the sharing features on this page, please enable JavaScript. An RBC nuclear scan uses small amounts of radioactive material to ...

  5. Nuclear Thermal Propulsion (NTP)

    NASA Video Gallery

    NASA's history with nuclear thermal propulsion (NTP) technology goes back to the earliest days of the Agency. The Manned Lunar Rover Vehicle and the Nuclear Engine for Rocket Vehicle Applications p...

  6. Nuclear disarmament verification

    SciTech Connect

    DeVolpi, A.

    1993-12-31

    Arms control treaties, unilateral actions, and cooperative activities -- reflecting the defusing of East-West tensions -- are causing nuclear weapons to be disarmed and dismantled worldwide. In order to provide for future reductions and to build confidence in the permanency of this disarmament, verification procedures and technologies would play an important role. This paper outlines arms-control objectives, treaty organization, and actions that could be undertaken. For the purposes of this Workshop on Verification, nuclear disarmament has been divided into five topical subareas: Converting nuclear-weapons production complexes, Eliminating and monitoring nuclear-weapons delivery systems, Disabling and destroying nuclear warheads, Demilitarizing or non-military utilization of special nuclear materials, and Inhibiting nuclear arms in non-nuclear-weapons states. This paper concludes with an overview of potential methods for verification.

  7. Nuclear fear revisited

    NASA Astrophysics Data System (ADS)

    Crease, Robert P.

    2010-10-01

    In 1988 the science historian Spencer Weart published a groundbreaking book called Nuclear Fear: A History of Images, which examined visions of radiation damage and nuclear disaster in newspapers, television, film, literature, advertisements and popular culture.

  8. Triangle Universities Nuclear Laboratory

    SciTech Connect

    Not Available

    1991-01-01

    This report contains brief papers that discusses the following topics: Fundamental Symmetries in the Nucleus; Internucleon Interactions; Dynamics of Very Light Nuclei; Facets of the Nuclear Many-Body Problem; and Nuclear Instruments and Methods.

  9. Teaching "The Nuclear Predicament."

    ERIC Educational Resources Information Center

    Carman, Philip; Kneeshaw, Stephen

    1987-01-01

    Contends that courses on nuclear war must help students examine the political, social, religious, philosophical, economic, and moral assumptions which characterized the dilemma of nuclear armament/disarmament. Describes the upper level undergraduate course taught by the authors. (JDH)

  10. Nuclear Energy Policy

    DTIC Science & Technology

    2010-05-27

    small modular reactors and extend the lives and improve the operation of existing commercial nuclear power plants. 40 Interdisciplinary MIT Study, The Future of Nuclear Power, Massachusetts Institute of Technology, 2003, p. 79. 41 Gronlund, Lisbeth, David Lochbaum, and Edwin Lyman, Nuclear Power in a Warming World, Union of Concerned Scientists, December 2007. 42 Travis Madsen, Tony Dutzik, and Bernadette Del Chiaro, et al., Generating Failure: How Building Nuclear Power Plants

  11. JPRS Report, Nuclear Developments

    DTIC Science & Technology

    2016-03-24

    of efforts to improve the safety of nuclear reactors that were started together with the USSR. These efforts are focused in particular on...characteristics of these reactors are quite encouraging. With their improved safety and low radiation effect on environment they ensure the possi...Nuclear Power [KYODO] 3 Fukushima Nuclear Reactor Reports Leak [KYODO] 3 NORTH KOREA Nuclear Weapons Capability Discussed by ROK Paper

  12. Nuclear power browning out

    SciTech Connect

    Flavin, C.; Lenssen, N.

    1996-05-01

    When the sad history of nuclear power is written, April 26, 1986, will be recorded as the day the dream died. The explosion at the Chernobyl plant was a terrible human tragedy- and it delivered a stark verdict on the hope that nuclear power will one day replace fossil fuel-based energy systems. Nuclear advocates may soldier on, but a decade after Chernobyl it is clear that nuclear power is no longer a viable energy option for the twenty-first century.

  13. JPRS Report Nuclear Developments

    DTIC Science & Technology

    2007-11-02

    release; Distribution Unlimited | -—fb 40 Nuclear Developments JPRS-TND-88-016 CONTENTS 2 SEPTEMBER 1988 CHINA Nuclear Power Chief Seeks...Foreign Cooperation [Yuan Zhou; CHINA DAILY (BUSINESS WEEKLY) 1 Aug 88] 1 Nuclear Fusion Study Reaches Advanced Level [Xiao Longlian; Beijing...Government ’Welcomes’ Group [Beijing XINHUA 12 Aug 88] 4 No Decision on Disposal of Daya Nuclear Waste [Andy Ho; Hong Kong SOUTH CHINA MORNING POST

  14. Nuclear air cushion vehicles.

    NASA Technical Reports Server (NTRS)

    Anderson, J. L.

    1973-01-01

    This paper serves several functions. It identifies the 'state-of-the-art' of the still-conceptual nuclear air cushion vehicle, particularly the nuclear powerplant. Using mission studies and cost estimates, the report describes some of the advantages of nuclear power for large air cushion vehicles. The paper also summarizes the technology studies on mobile nuclear powerplants and conceptual ACV systems/missions studies that have been performed at NASA Lewis Research Center.

  15. NUCLEAR REACTOR CONTROL SYSTEM

    DOEpatents

    Epler, E.P.; Hanauer, S.H.; Oakes, L.C.

    1959-11-01

    A control system is described for a nuclear reactor using enriched uranium fuel of the type of the swimming pool and other heterogeneous nuclear reactors. Circuits are included for automatically removing and inserting the control rods during the course of normal operation. Appropriate safety circuits close down the nuclear reactor in the event of emergency.

  16. Revitalizing Nuclear Safety Research.

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC.

    This report covers the general issues involved in nuclear safety research and points out the areas needing detailed consideration. Topics included are: (1) "Principles of Nuclear Safety Research" (examining who should fund, who should conduct, and who should set the agenda for nuclear safety research); (2) "Elements of a Future…

  17. Nuclear energy technology

    NASA Technical Reports Server (NTRS)

    Buden, David

    1992-01-01

    An overview of space nuclear energy technologies is presented. The development and characteristics of radioisotope thermoelectric generators (RTG's) and space nuclear power reactors are discussed. In addition, the policy and issues related to public safety and the use of nuclear power sources in space are addressed.

  18. JPRS Report, Nuclear Developments

    DTIC Science & Technology

    2016-03-24

    a new generation of nuclear Because of the significant improvements in radiation read- reactors with an increased degree of safety are developed...With USSR [Moscow PRA VDA 14 Aug] ...................... 14 Future Nuclear Reactor Plans Detailed fIslamnahad Radio...July Stoppages /Moscow International] ........................................... 19 Suspension of Nuclear Reactor Construction Urged ITASS

  19. JPRS Report, Nuclear Developments

    DTIC Science & Technology

    2016-03-24

    extraction plant in collaboration with the Fer- Prototype Fast Breeder Reactor (PFBR). tilizers and Chemicals , Travancore (FACT) at Eloor near Cochin...Nuclear Reactor Shut Down After Malfunction [KYODO] ................................................................ 8 PHILIPPINES Proposal To Operate...Nuclear Reactor in Algeria [TELAM] .............................................................. 10 Nuclear Official Returns From Algeria [TELAM

  20. Teaching Nuclear History.

    ERIC Educational Resources Information Center

    Holl, Jack M.; Convis, Sheila C.

    1991-01-01

    Presents results of a survey of the teaching about nuclear history at U.S. colleges and universities. Reports the existence of a well-established and extensive literature, a focus on nuclear weapons or warfare, and a concentration on nuclear citizenship, therapy, or eschatology for courses outside of history departments. Discusses individual…

  1. Nuclear Medicine Imaging

    MedlinePlus

    ... necesita saber acerca de... Estudios de Imagen de Medicina Nuclear Un procedimiento de medicina nuclear se describe algunas veces como unos rayos- ... través del cuerpo del paciente. Los procedimientos de medicina nuclear utilizan pequeñas cantidades de mate- riales radiactivos, ...

  2. Nuclear fact book

    SciTech Connect

    Hill, O. F.; Platt, A. M.; Robinson, J. V.

    1983-05-01

    This reference provides significant highlights and summary facts in the following areas: general energy; nuclear energy; nuclear fuel cycle; uranium supply and enrichment; nuclear reactors; spent fuel and advanced repacking concepts; reprocessing; high-level waste; gaseous waste; transuranic waste; low-level waste; remedial action; transportation; disposal; radiation information; environment; legislation; socio-political aspects; conversion factors; and a glossary. (GHT)

  3. Effects of Nuclear Weapons.

    ERIC Educational Resources Information Center

    Sartori, Leo

    1983-01-01

    Fundamental principles governing nuclear explosions and their effects are discussed, including three components of a nuclear explosion (thermal radiation, shock wave, nuclear radiation). Describes how effects of these components depend on the weapon's yield, its height of burst, and distance of detonation point. Includes effects of three…

  4. Basic Nuclear Physics.

    ERIC Educational Resources Information Center

    Bureau of Naval Personnel, Washington, DC.

    Basic concepts of nuclear structures, radiation, nuclear reactions, and health physics are presented in this text, prepared for naval officers. Applications to the area of nuclear power are described in connection with pressurized water reactors, experimental boiling water reactors, homogeneous reactor experiments, and experimental breeder…

  5. Recent developments in Topaz-II reactor safety assessments

    SciTech Connect

    Marshall, A.C. )

    1993-01-01

    In December 1991, the Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of a US launch of a Russian Topaz-II space nuclear power system. The primary mission goal would be to demonstrate and evaluate nuclear electric propulsion technology to establish a capability for future civilian and military missions. A preliminary nuclear safety analysis was initiated to determine whether or not a space mission could be conducted safely and within budget constraints. This paper describes preliminary safety analysis results and the nuclear safety program now being established for the NEP space test (NEPST).

  6. 10 CFR Appendix E to Part 73 - Levels of Physical Protection To Be Applied in International Transport of Nuclear Material 1

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... International Transport of Nuclear Material 1 E Appendix E to Part 73 Energy NUCLEAR REGULATORY COMMISSION... Physical Protection To Be Applied in International Transport of Nuclear Material 1 1 See appendix C to part... II is special nuclear material of moderate strategic significance or irradiated fuel; and...

  7. Changing Facets of Nuclear Structure

    NASA Astrophysics Data System (ADS)

    Covello, Aldo

    2008-04-01

    Section I. Exotic nuclear structure. Radioactive beams at TRIUMF / A. C. Shotter. Status of RI-beam factory project at RIKEN / H. Ueno. Population of neutron unbound states via two-proton knockout reactions / N. Frank ... [et al.]. Studies of neutron-rich nuclei using ISOL facilities at CERN and Jyväskylä / J. Äystö. Shell structure evolution far from stability: recent results from GANIL / F. Azaiez. Magnetic moment meaurements: pushing the limits / N. Benczer-Koller. Technique for measuring angular correlations and g-factors of excited states with large multi-detector arrays: an application to neutron rich nuclei produced in spontaneous fission / A. V. Ramayya ... [et al.]. Isospin symmetry and proton decay: identification of the 10+ isomer in [symbol]Ni / C. Fahlander ... [et al.]. Exploring the evolution of the shell structure by means of deep inelastic reactions / G. de Angelis. Studies on the exotic structure of [symbol]Al by measurements of [symbol] and P[symbol] / D. Q. Fang ... [et al.]. Extended cluster model for light and medium nuclei / M. Tomaselli ... [et al.]. Nuclear structure studies on exotic nuclei with radioactive beams - present status and future perspectives at FAIR / P. Egelhof. The SPES direct target project at the Laboratori Nazionali di Legnaro / G. Prete ... [et al.] -- Section II. Nuclear structure and nuclear forces. Modern aspects of nuclear structure theory / J. Wambach. Correlations in nuclei: a review / R. Schiavilla. Correlated nucleons in k- and r-space / I. Sick. Roles of all-order core polarizations and Brown-Rho scaling in nucleon effective interactions / T. T. S. Kuo ... [et al.]. Ab initio and ab exitu no core shell model / J. P. Vary ... [et al.]. Ab-initio coupled cluster theory for open quantum systems / G. Hagen ... [et al.]. Symplectic no-core shell model / J. P. Draayer ... [et al.]. Role of deformed symplectic configurations in ab initio no-core shell model results / T. Dytrych ... [et al.]. Nuclear structure

  8. History of Nuclear India

    NASA Astrophysics Data System (ADS)

    Chaturvedi, Ram

    2000-04-01

    India emerged as a free and democratic country in 1947, and entered into the nuclear age in 1948 by establishing the Atomic Energy Commission (AEC), with Homi Bhabha as the chairman. Later on the Department of Atomic Energy (DAE) was created under the Office of the Prime Minister Jawahar Lal Nehru. Initially the AEC and DAE received international cooperation, and by 1963 India had two research reactors and four nuclear power reactors. In spite of the humiliating defeat in the border war by China in 1962 and China's nuclear testing in 1964, India continued to adhere to the peaceful uses of nuclear energy. On May 18, 1974 India performed a 15 kt Peaceful Nuclear Explosion (PNE). The western powers considered it nuclear weapons proliferation and cut off all financial and technical help, even for the production of nuclear power. However, India used existing infrastructure to build nuclear power reactors and exploded both fission and fusion devices on May 11 and 13, 1998. The international community viewed the later activity as a serious road block for the Non-Proliferation Treaty and the Comprehensive Test Ban Treaty; both deemed essential to stop the spread of nuclear weapons. India considers these treaties favoring nuclear states and is prepared to sign if genuine nuclear disarmament is included as an integral part of these treaties.

  9. Commercial nuclear power 1990

    SciTech Connect

    Not Available

    1990-09-28

    This report presents the status at the end of 1989 and the outlook for commercial nuclear capacity and generation for all countries in the world with free market economies (FME). The report provides documentation of the US nuclear capacity and generation projections through 2030. The long-term projections of US nuclear capacity and generation are provided to the US Department of Energy's (DOE) Office of Civilian Radioactive Waste Management (OCRWM) for use in estimating nuclear waste fund revenues and to aid in planning the disposal of nuclear waste. These projections also support the Energy Information Administration's annual report, Domestic Uranium Mining and Milling Industry: Viability Assessment, and are provided to the Organization for Economic Cooperation and Development. The foreign nuclear capacity projections are used by the DOE uranium enrichment program in assessing potential markets for future enrichment contracts. The two major sections of this report discuss US and foreign commercial nuclear power. The US section (Chapters 2 and 3) deals with (1) the status of nuclear power as of the end of 1989; (2) projections of nuclear capacity and generation at 5-year intervals from 1990 through 2030; and (3) a discussion of institutional and technical issues that affect nuclear power. The nuclear capacity projections are discussed in terms of two projection periods: the intermediate term through 2010 and the long term through 2030. A No New Orders case is presented for each of the projection periods, as well as Lower Reference and Upper Reference cases. 5 figs., 30 tabs.

  10. The nuclear symmetry energy

    NASA Astrophysics Data System (ADS)

    Baldo, M.; Burgio, G. F.

    2016-11-01

    The nuclear symmetry energy characterizes the variation of the binding energy as the neutron to proton ratio of a nuclear system is varied. This is one of the most important features of nuclear physics in general, since it is just related to the two component nature of the nuclear systems. As such it is one of the most relevant physical parameters that affect the physics of many phenomena and nuclear processes. This review paper presents a survey of the role and relevance of the nuclear symmetry energy in different fields of research and of the accuracy of its determination from the phenomenology and from the microscopic many-body theory. In recent years, a great interest was devoted not only to the Nuclear Matter symmetry energy at saturation density but also to its whole density dependence, which is an essential ingredient for our understanding of many phenomena. We analyze the nuclear symmetry energy in different realms of nuclear physics and astrophysics. In particular we consider the nuclear symmetry energy in relation to nuclear structure, astrophysics of Neutron Stars and supernovae, and heavy ion collision experiments, trying to elucidate the connections of these different fields on the basis of the symmetry energy peculiarities. The interplay between experimental and observational data and theoretical developments is stressed. The expected future developments and improvements are schematically addressed, together with most demanded experimental and theoretical advances for the next few years.

  11. Thermodynamics of nuclear transport

    NASA Astrophysics Data System (ADS)

    Wang, Ching-Hao; Mehta, Pankaj; Elbaum, Michael

    Molecular transport across the nuclear envelope is important for eukaryotes for gene expression and signaling. Experimental studies have revealed that nuclear transport is inherently a nonequilibrium process and actively consumes energy. In this work we present a thermodynamics theory of nuclear transport for a major class of nuclear transporters that are mediated by the small GTPase Ran. We identify the molecular elements responsible for powering nuclear transport, which we term the ``Ran battery'' and find that the efficiency of transport, measured by the cargo nuclear localization ratio, is limited by competition between cargo molecules and RanGTP to bind transport receptors, as well as the amount of NTF2 (i.e. RanGDP carrier) available to circulate the energy flow. This picture complements our current understanding of nuclear transport by providing a comprehensive thermodynamics framework to decipher the underlying biochemical machinery. Pm and CHW were supported by a Simons Investigator in the Mathematical Modeling in Living Systems grant (to PM).

  12. Cytotoxic copper(II), cobalt(II), zinc(II), and nickel(II) coordination compounds of clotrimazole.

    PubMed

    Betanzos-Lara, Soledad; Gómez-Ruiz, Celedonio; Barrón-Sosa, Lidia R; Gracia-Mora, Isabel; Flores-Álamo, Marcos; Barba-Behrens, Noráh

    2012-09-01

    Sixteen novel mononuclear Cu(II), Co(II), Zn(II), and Ni(II) complexes of the biologically active ligand clotrimazole (clotri) of the forms [M(clotri)(2)Cl(2)]·nH(2)O (1-4), [M(clotri)(2)Br(2)]·nH(2)O (5-7), [M(clotri)(3)Br(2)] (8), [M(clotri)(3)NO(3)]NO(3)·nH(2)O (9, 11), [M(clotri)(3)(NO(3))(2)]·nH(2)O (10), and [M(clotri)(3)(OH(2))(2)NO(3)]NO(3)·nH(2)O (12) were synthesized and fully characterized. Dinuclear [Cu(2)(clotri)(4)μ(2)-Cl(4)]·2H(2)O (1a) and [Cu(2)(clotri)(4)μ(2)-Br(2)]·2H(2)O (5b) as well as tetranuclear [Cu(4)(clotri)(4)μ(4)-Br(6)μ(4)-O] (5a) complexes were also isolated. Complexes 1-7, 9, and 11 present a tetrahedral geometry; complex 8 exhibits a pentacoordinated structure; complexes 1a, 10 and 12 an octahedral geometry. X-ray crystal structures of [Cu(clotri)(2)Cl(2)](1), [Cu(clotri)(2)(EtOH)Cl(2)](1·EtOH), [Zn(clotri)(2)Cl(2)] (3), [Zn(clotri)(2)Br(2)] (7), and [Cu(4)(clotri)(4)μ(4)-Br(6)μ(4)-O] (5a) were obtained. Complexes 1-12 were tested for cytotoxic activity against the human carcinoma cell lines HeLa (cervix-uterine), PC3 (prostate), and HCT-15 (colon) displaying IC(50) values <30 μM. Confocal microscopy and nuclear dying (DAPI) for complex 1 showed condensation of cromatin and nuclear membrane fragmentation. Immunocytochemical detection/expression of biomarkers suggests that complexes 1 and 9 induce cell death via apoptosis. TUNEL assay detected DNA fragmentation in HeLa cells, resulting from apoptotic signaling cascades induced by Cu(II) complexes 1 and 9. (1)H NMR studies of the Zn(II) complexes showed that they can bind to nucleotides.

  13. Nuclear Concrete Materials Database Phase I Development

    SciTech Connect

    Ren, Weiju; Naus, Dan J

    2012-05-01

    The FY 2011 accomplishments in Phase I development of the Nuclear Concrete Materials Database to support the Light Water Reactor Sustainability Program are summarized. The database has been developed using the ORNL materials database infrastructure established for the Gen IV Materials Handbook to achieve cost reduction and development efficiency. In this Phase I development, the database has been successfully designed and constructed to manage documents in the Portable Document Format generated from the Structural Materials Handbook that contains nuclear concrete materials data and related information. The completion of the Phase I database has established a solid foundation for Phase II development, in which a digital database will be designed and constructed to manage nuclear concrete materials data in various digitized formats to facilitate electronic and mathematical processing for analysis, modeling, and design applications.

  14. Fifty years with nuclear fission. Volume 2

    SciTech Connect

    Behrens, J.W.; Carlson, A.D.

    1989-12-31

    The news of the discovery of nucler fission, by Otto Hahn and Fritz Strassmann in Germany, was brought to the United States by Niels Bohr in January 1939. Since its discovery, the United States, and the world for that matter, has never been the same. It therefore seemed appropriate to acknowledge the fiftieth anniversary of its discovery by holding a topical meeting entitled, ``Fifty years with nuclear fission,`` in the United States during the year 1989. The objective of the meeting was to bring together pioneers of the nuclear industry and other scientists and engineers to report on reminiscences of the past and on the more recent developments in fission science and technology. The conference highlighted the early pioneers of the nuclear industry by dedicating a full day (April 26), consisting of two plenary sessions, at the National Academy of Sciences (NAS) in Washington, DC. More recent developments in fission science and technology in addition to historical reflections were topics for two full days of sessions (April 27 and 28) at the main sites of the NIST in Gaithersburg, Maryland. The wide range of topics covered by Volume 2 of this topical meeting included plenary invited, and contributed sessions entitled, Nuclear fission -- a prospective; reactors II; fission science II; medical and industrial applications by by-products; reactors and safeguards; general research, instrumentation, and by-products; and fission data, astrophysics, and space applications. The individual papers have been cataloged separately.

  15. 75 FR 30078 - Entergy Nuclear Operations, Inc.; Entergy Nuclear Vermont Yankee, LLC; Vermont Yankee Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... Office of Nuclear Reactor Regulation (NRR). By letter dated May 20, 2010, the Director denied the... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc.; Entergy Nuclear Vermont Yankee, LLC; Vermont Yankee...

  16. Assembly dynamics of PML nuclear bodies in living cells.

    PubMed

    Brand, Peter; Lenser, Thorsten; Hemmerich, Peter

    2010-03-05

    The mammalian cell nucleus contains a variety of organelles or nuclear bodies which contribute to key nuclear functions. Promyelocytic leukemia nuclear bodies (PML NBs) are involved in the regulation of apoptosis, antiviral responses, the DNA damage response and chromatin structure, but their precise biochemical function in these nuclear pathways is unknown. One strategy to tackle this problem is to assess the biophysical properties of the component parts of these macromolecular assemblies in living cells. In this study we determined PML NB assembly dynamics by live cell imaging, combined with mathematical modeling. For the first time, dynamics of PML body formation were measured in cells lacking endogenous PML. We show that all six human nuclear PML isoforms are able to form nuclear bodies in PML negative cells. All isoforms exhibit individual exchange rates at NBs in PML positive cells but PML I, II, III and IV are static at nuclear bodies in PML negative cells, suggesting that these isoforms require additional protein partners for efficient exchange. PML V turns over at PML Nbs very slowly supporting the idea of a structural function for this isoform. We also demonstrate that SUMOylation of PML at Lysine positions K160 and/or K490 are required for nuclear body formation in vivo.We propose a model in which the isoform specific residence times of PML provide both, structural stability to function as a scaffold and flexibility to attract specific nuclear proteins for efficient biochemical reactions at the surface of nuclear bodies.MCS code: 92C37.

  17. Inhibition of endogenous heat shock protein 70 attenuates inducible nitric oxide synthase induction via disruption of heat shock protein 70/Na(+) /H(+) exchanger 1-Ca(2+) -calcium-calmodulin-dependent protein kinase II/transforming growth factor β-activated kinase 1-nuclear factor-κB signals in BV-2 microglia.

    PubMed

    Huang, Chao; Lu, Xu; Wang, Jia; Tong, Lijuan; Jiang, Bo; Zhang, Wei

    2015-08-01

    Inducible nitric oxide synthase (iNOS) critically contributes to inflammation and host defense. The inhibition of heat shock protein 70 (Hsp70) prevents iNOS induction in lipopolysaccharide (LPS)-stimulated macrophages. However, the role and mechanism of endogenous Hsp70 in iNOS induction in microglia remains unclear. This study addresses this issue in BV-2 microglia, showing that Hsp70 inhibition or knockdown prevents LPS-induced iNOS protein expression and nitric oxide production. Real-time PCR experiments showed that LPS-induced iNOS mRNA transcription was blocked by Hsp70 inhibition. Further studies revealed that the inhibition of Hsp70 attenuated LPS-stimulated nuclear translocation and phosphorylation of nuclear factor (NF)-κB as well as the degradation of inhibitor of κB (IκB)-α and phosphorylation of IκB kinase β (IKKβ). This prevention effect of Hsp70 inhibition on IKKβ-NF-κB activation was found to be dependent on the Ca(2+) /calcium-calmodulin-dependent protein kinase II (CaMKII)/transforming growth factor β-activated kinase 1 (TAK1) signals based on the following observations: 1) chelation of intracellular Ca(2+) or inhibition of CaMKII reduced LPS-induced increases in TAK1 phosphorylation and 2) Hsp70 inhibition reduced LPS-induced increases in CaMKII/TAK1 phosphorylation, intracellular pH value, [Ca(2+) ]i , and CaMKII/TAK1 association. Mechanistic studies showed that Hsp70 inhibition disrupted the association between Hsp70 and Na(+) /H(+) exchanger 1 (NHE1), which is an important exchanger responsible for Ca(2+) influx in LPS-stimulated cells. These studies demonstrate that the inhibition of endogenous Hsp70 attenuates the induction of iNOS, which likely occurs through the disruption of NHE1/Hsp70-Ca(2+) -CaMKII/TAK1-NF-κB signals in BV-2 microglia, providing further insight into the functions of Hsp70 in the CNS.

  18. Spectroscopic (FT-IR, FT-Raman, 1H, 13C NMR, UV/VIS), thermogravimetric and antimicrobial studies of Ca(II), Mn(II), Cu(II), Zn(II) and Cd(II) complexes of ferulic acid

    NASA Astrophysics Data System (ADS)

    Kalinowska, M.; Piekut, J.; Bruss, A.; Follet, C.; Sienkiewicz-Gromiuk, J.; Świsłocka, R.; Rzączyńska, Z.; Lewandowski, W.

    2014-03-01

    The molecular structure of Mn(II), Cu(II), Zn(II), Cd(II) and Ca(II) ferulates (4-hydroxy-3-methoxycinnamates) was studied. The selected metal ferulates were synthesized. Their composition was established by means of elementary and thermogravimetric analysis. The following spectroscopic methods were used: infrared (FT-IR), Raman (FT-Raman), nuclear magnetic resonance (13C, 1H NMR) and ultraviolet-visible (UV/VIS). On the basis of obtained results the electronic charge distribution in studied metal complexes in comparison with ferulic acid molecule was discussed. The microbiological study of ferulic acid and ferulates toward Escherichia coli, Bacillus subtilis, Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus and Proteus vulgaris was done.

  19. British nuclear policymaking

    SciTech Connect

    Bowie, C.J.; Platt, A.

    1984-01-01

    This study analyzes the domestic political, economic, and bureaucratic factors that affect the nuclear policymaking process in Great Britain. Its major conclusion is that, although there have been changes in that process in recent years (notably the current involvement of a segment of the British public in the debate about the deployment of intermediate-range nuclear forces), future British nuclear policymaking will remain much what it has been in the past. Three ideas are central to understanding British thinking on the subject: (1) Britain's long-standing resolve to have her own national nuclear force is largely traceable to her desire to maintain first-rank standing among the nations of the world in spite of loss of empire. (2) Financial considerations have always been important--so much so that they have usually dominated issues of nuclear policy. (3) The executive branch of government dominates the nuclear policymaking process but does not always present a united front. The United States heavily influences British nuclear policy through having supplied Britain since the late 1950s with nuclear data and components of nuclear weapon systems such as Polaris and Trident. The relationship works both ways since the U.S. depends on Britain as a base for deployment of both conventional and nuclear systems.

  20. 10 CFR 73.51 - Requirements for the physical protection of stored spent nuclear fuel and high-level radioactive...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... nuclear fuel and high-level radioactive waste. 73.51 Section 73.51 Energy NUCLEAR REGULATORY COMMISSION... radioactive waste pursuant to paragraphs (a)(1)(i), (ii), and (2) of this section. This includes— (1) Spent nuclear fuel and high-level radioactive waste stored under a specific license issued pursuant to part...

  1. 10 CFR 73.51 - Requirements for the physical protection of stored spent nuclear fuel and high-level radioactive...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... nuclear fuel and high-level radioactive waste. 73.51 Section 73.51 Energy NUCLEAR REGULATORY COMMISSION... radioactive waste pursuant to paragraphs (a)(1)(i), (ii), and (2) of this section. This includes— (1) Spent nuclear fuel and high-level radioactive waste stored under a specific license issued pursuant to part...

  2. 10 CFR 73.51 - Requirements for the physical protection of stored spent nuclear fuel and high-level radioactive...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... nuclear fuel and high-level radioactive waste. 73.51 Section 73.51 Energy NUCLEAR REGULATORY COMMISSION... radioactive waste pursuant to paragraphs (a)(1)(i), (ii), and (2) of this section. This includes— (1) Spent nuclear fuel and high-level radioactive waste stored under a specific license issued pursuant to part...

  3. 10 CFR 73.51 - Requirements for the physical protection of stored spent nuclear fuel and high-level radioactive...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... nuclear fuel and high-level radioactive waste. 73.51 Section 73.51 Energy NUCLEAR REGULATORY COMMISSION... radioactive waste pursuant to paragraphs (a)(1)(i), (ii), and (2) of this section. This includes— (1) Spent nuclear fuel and high-level radioactive waste stored under a specific license issued pursuant to part...

  4. 10 CFR 73.51 - Requirements for the physical protection of stored spent nuclear fuel and high-level radioactive...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... nuclear fuel and high-level radioactive waste. 73.51 Section 73.51 Energy NUCLEAR REGULATORY COMMISSION... radioactive waste pursuant to paragraphs (a)(1)(i), (ii), and (2) of this section. This includes— (1) Spent nuclear fuel and high-level radioactive waste stored under a specific license issued pursuant to part...

  5. Evaluating Russian space nuclear reactor technology for United States applications

    SciTech Connect

    Polansky, G.F.; Schmidt, G.L.; Voss, S.S.; Reynolds, E.L.

    1994-08-01

    Space nuclear power and nuclear electric propulsion are considered important technologies for planetary exploration, as well as selected earth orbit applications. The Nuclear Electric Propulsion Space Test Program (NEPSTP) was intended to provide an early flight demonstration of these technologies at relatively low cost through extensive use of existing Russian technology. The key element of Russian technology employed in the program was the Topaz II reactor. Refocusing of the activities of the Ballistic Missile Defense Organization (BMDO), combined with budgetary pressures, forced the cancellation of the NEPSTP at the end of the 1993 fiscal year. The NEPSTP was faced with many unique flight qualification issues. In general, the launch of a spacecraft employing a nuclear reactor power system complicates many spacecraft qualification activities. However, the NEPSTP activities were further complicated because the reactor power system was a Russian design. Therefore, this program considered not only the unique flight qualification issues associated with space nuclear power, but also with differences between Russian and United States flight qualification procedures. This paper presents an overview of the NEPSTP. The program goals, the proposed mission, the spacecraft, and the Topaz II space nuclear power system are described. The subject of flight qualification is examined and the inherent difficulties of qualifying a space reactor are described. The differences between United States and Russian flight qualification procedures are explored. A plan is then described that was developed to determine an appropriate flight qualification program for the Topaz II reactor to support a possible NEPSTP launch.

  6. Economics of nuclear power.

    PubMed

    Rossin, A D; Rieck, T A

    1978-08-18

    With 12 percent of U.S. electricity now being supplied by nuclear power, Commonwealth Edison has found nuclear plants to be good investments relative to other base load energy sources. The country's largest user of nuclear power, Commonwealth Edison, estimates that its commitment to nuclear saved its customers about 10 percent on their electric bills in 1977, compared to the cost with the next best alternative, coal. This advantage is seen as continuing, contrary to criticisms of the economics and reliability of nuclear power and claims that it has hidden subsidies. It is concluded that there is a need for both nuclear and coal and that government policy precluding or restricting either would be unwise.

  7. Nuclear Science References Database

    SciTech Connect

    Pritychenko, B.; Běták, E.; Singh, B.; Totans, J.

    2014-06-15

    The Nuclear Science References (NSR) database together with its associated Web interface, is the world's only comprehensive source of easily accessible low- and intermediate-energy nuclear physics bibliographic information for more than 210,000 articles since the beginning of nuclear science. The weekly-updated NSR database provides essential support for nuclear data evaluation, compilation and research activities. The principles of the database and Web application development and maintenance are described. Examples of nuclear structure, reaction and decay applications are specifically included. The complete NSR database is freely available at the websites of the National Nuclear Data Center (http://www.nndc.bnl.gov/nsr) and the International Atomic Energy Agency (http://www-nds.iaea.org/nsr)

  8. Absolute nuclear material assay

    DOEpatents

    Prasad, Manoj K [Pleasanton, CA; Snyderman, Neal J [Berkeley, CA; Rowland, Mark S [Alamo, CA

    2012-05-15

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  9. Absolute nuclear material assay

    DOEpatents

    Prasad, Manoj K.; Snyderman, Neal J.; Rowland, Mark S.

    2010-07-13

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  10. Nuclear Fabrication Consortium

    SciTech Connect

    Levesque, Stephen

    2013-04-05

    This report summarizes the activities undertaken by EWI while under contract from the Department of Energy (DOE) Office of Nuclear Energy (NE) for the management and operation of the Nuclear Fabrication Consortium (NFC). The NFC was established by EWI to independently develop, evaluate, and deploy fabrication approaches and data that support the re-establishment of the U.S. nuclear industry: ensuring that the supply chain will be competitive on a global stage, enabling more cost-effective and reliable nuclear power in a carbon constrained environment. The NFC provided a forum for member original equipment manufactures (OEM), fabricators, manufacturers, and materials suppliers to effectively engage with each other and rebuild the capacity of this supply chain by : Identifying and removing impediments to the implementation of new construction and fabrication techniques and approaches for nuclear equipment, including system components and nuclear plants. Providing and facilitating detailed scientific-based studies on new approaches and technologies that will have positive impacts on the cost of building of nuclear plants. Analyzing and disseminating information about future nuclear fabrication technologies and how they could impact the North American and the International Nuclear Marketplace. Facilitating dialog and initiate alignment among fabricators, owners, trade associations, and government agencies. Supporting industry in helping to create a larger qualified nuclear supplier network. Acting as an unbiased technology resource to evaluate, develop, and demonstrate new manufacturing technologies. Creating welder and inspector training programs to help enable the necessary workforce for the upcoming construction work. Serving as a focal point for technology, policy, and politically interested parties to share ideas and concepts associated with fabrication across the nuclear industry. The report the objectives and summaries of the Nuclear Fabrication Consortium

  11. Pakistans Nuclear Weapons

    DTIC Science & Technology

    2016-02-12

    2004 revelations about a procurement network run by former Pakistani nuclear official A. Q. Khan, Islamabad has taken a number of steps to improve ...strengthened export control laws, improved personnel security, and international nuclear security cooperation programs, have improved Pakistan’s...context where these broader tensions and conflicts are present. 1 Pakistani efforts to improve the security of its nuclear weapons have been ongoing

  12. Nuclear Proliferation Challenges

    SciTech Connect

    Professor William Potter

    2005-11-28

    William C. Potter, Director of the Center for Non Proliferation Studies and the Center for Russian and Eurasian Studies at the Monterey Institute of International Studies, will present nuclear proliferation challenges following the 2005 Nuclear Non-Proliferation Treaty (NPT) Review Conference. In addition to elucidating reasons for, and implications of, the conference’s failure, Dr. Potter will discuss common ground between nuclear proliferation and terrorism issues and whether corrective action can be taken.

  13. Nuclear imaging in pediatrics

    SciTech Connect

    Siddiqui, A.R.

    1985-01-01

    The author's intent is to familiarize practicing radiologists with the technical aspects and interpretation of nuclear medicine procedures in children and to illustrate the indications for nuclear medicine procedures in pediatric problems. Pediatric doses, dosimetry, sedation, and injection techniques, organ systems, oncology and infection, testicular scanning and nuclear crystography, pediatric endocrine and skeletal systems, ventilation and perfusion imaging of both congenital and acquired pediatric disorders, cardiovascular problems, gastrointestinal, hepatobiliary, reticuloendothelial studies, and central nervous system are all topics which are included and discussed.

  14. Nuclear Politics in Iran

    DTIC Science & Technology

    2010-05-01

    system. States with prestige are recognized by other actors as having a high 21 Nuclear Politics in Iran standing either generally or with regard to...Nuclear Politics in Iran Edited by Judith S. Yaphe MIDDLE EAST STRATEGIC PERSPECTIVES 1 Center for Strategic Research Institute for National...OMB control number. 1. REPORT DATE MAY 2010 2. REPORT TYPE 3. DATES COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Nuclear Politics in

  15. Nonstrategic Nuclear Weapons

    DTIC Science & Technology

    2014-01-03

    William Potter , and Nikolai Sokov, Reducing and Regulating Tactical (Nonstrategic) Nuclear Weapons in Europe, The James Martin Center For...See William C. Potter and Nikolai Sokov, “Nuclear Weapons that People Forget,” International Herald Tribune, May 31, 2000. 87 Sam Nunn, Igor...their security.97 94 Kent Harris , “NATO Allies Want U.S. Nuclear Weapons out of Europe

  16. TRUPACT-II, a regulatory perspective

    SciTech Connect

    Gregory, P.C.; Spooner, O.R.

    1995-12-31

    The Transuranic Package Transporter II (TRUPACT-II) is a US Nuclear Regulatory Commission (NRC) certified Type B packaging for the shipment of contact-handled transuranic (CH-TRU) material by the US Department of Energy (DOE). The NRC approved the TRUPACT-II design as meeting the requirements of Title 10, Code of Federal Regulations, Part 71 (10 CFR 71) and issued Certificate of Compliance (CofC) Number 9218 to the DOE. There are currently 15 certified TRUPACT-IIs. Additional TRUPACT-IIs will be required to make more than 15,000 shipments of CH-TRU waste to the Waste Isolation Pilot Plant (WIPP) site near Carlsbad, New Mexico. The TRUPACT-II may also be used for the DOE inter-site and intra-site shipments of CH-TRU waste. The Land Withdrawal Act (Public Law 102-579), enacted by the US Congress, October 30, 1992, and an agreement between the DOE and the State of New Mexico, signed August 4, 1987, both stipulate that only NRC approved packaging may be used for shipments of TRU waste to the WIPP. Early in the TRUPACT-II development phase it was decided that the transportation system (tractor, trailer, and TRUPACT-II) should be highway legal on all routes without the need for oversize and/or overweight permits. In large measure, public acceptance of the DOE`s efforts to safely transport CH-TRU waste depends on the public`s perception that the TRUPACT-II is in compliance with all applicable regulations, standards, and quality assurance requirements. This paper addresses some of the numerous regulations applicable to Type B packaging, and it describes how the TRUPACT-II complies with these regulations.

  17. Nuclear reactor apparatus

    DOEpatents

    Wade, Elman E.

    1978-01-01

    A lifting, rotating and sealing apparatus for nuclear reactors utilizing rotating plugs above the nuclear reactor core. This apparatus permits rotation of the plugs to provide under the plug refueling of a nuclear core. It also provides a means by which positive top core holddown can be utilized. Both of these operations are accomplished by means of the apparatus lifting the top core holddown structure off the nuclear core while stationary, and maintaining this structure in its elevated position during plug rotation. During both of these operations, the interface between the rotating member and its supporting member is sealingly maintained.

  18. Comprehensive Nuclear Materials

    SciTech Connect

    Konings, Dr. Rudy J. M.; Allen, Todd R.; Stoller, Roger E; Yamanaka, Prof. Shinsuke

    2012-01-01

    This book encompasses a rich seam of current information on the vast and multidisciplinary field of nuclear materials employed in fission and prototype fusion systems. Discussion includes both historical and contemporary international research in nuclear materials, from Actinides to Zirconium alloys, from the worlds leading scientists and engineers. Synthesizes pertinent current science to support the selection, assessment, validation and engineering of materials in extreme nuclear environments. The work discusses the major classes of materials suitable for usage in nuclear fission, fusion reactors and high power accelerators, and for diverse functions in fuels, cladding, moderator and control materials, structural, functional, and waste materials.

  19. [Nuclear families in Turkey].

    PubMed

    Unalan, T

    1988-01-01

    This study examines the household or family types in Turkey in 1983, especially nuclear families. Nuclear families constitute 61.6% of all households in Turkey, and the majority of them are in the West and the Central regions. The highest % of nuclear families was found in the Mediterranean regions, and the lowest in the Black Sea region. Among all nuclear families, 87% of them consist of husband, wife and children, whereas 13% of them have only husband and wife. Nuclear families without children are common in urban areas and in the West while nuclear families with children are mostly found in rural areas and in the East and the Black Sea regions. Nuclear families with 3 or more children constitute 32% of all nuclear households in the West. On the other hand, the corresponding % is 73 for the Eastern region. As a result, it is concluded that nuclear families have significant regional and residential differentiations and households with the same formation in a developed and a less developed region should have different social, economic, and cultural characteristics.

  20. Technologists for Nuclear Medicine

    ERIC Educational Resources Information Center

    Barnett, Huey D.

    1974-01-01

    Physicians need support personnel for work with radioisotopes in diagnosing dangerous diseases. The Nuclear Medicine Technology (NMT) Program at Hillsborough Community College in Tampa, Florida, is described. (MW)

  1. Nuclear criticality safety guide

    SciTech Connect

    Pruvost, N.L.; Paxton, H.C.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators.

  2. Radiation chemistry for modern nuclear energy development

    NASA Astrophysics Data System (ADS)

    Chmielewski, Andrzej G.; Szołucha, Monika M.

    2016-07-01

    Radiation chemistry plays a significant role in modern nuclear energy development. Pioneering research in nuclear science, for example the development of generation IV nuclear reactors, cannot be pursued without chemical solutions. Present issues related to light water reactors concern radiolysis of water in the primary circuit; long-term storage of spent nuclear fuel; radiation effects on cables and wire insulation, and on ion exchangers used for water purification; as well as the procedures of radioactive waste reprocessing and storage. Radiation effects on materials and enhanced corrosion are crucial in current (II/III/III+) and future (IV) generation reactors, and in waste management, deep geological disposal and spent fuel reprocessing. The new generation of reactors (III+ and IV) impose new challenges for radiation chemists due to their new conditions of operation and the usage of new types of coolant. In the case of the supercritical water-cooled reactor (SCWR), water chemistry control may be the key factor in preventing corrosion of reactor structural materials. This paper mainly focuses on radiation effects on long-term performance and safety in the development of nuclear power plants.

  3. Topaz II preliminary safety assessment

    NASA Astrophysics Data System (ADS)

    Marshall, Albert C.; Standley, Vaughn; Voss, Susan S.; Haskin, Eric

    1993-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  4. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. )

    1993-01-10

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  5. Nucleolus: the fascinating nuclear body

    PubMed Central

    Sirri, Valentina; Urcuqui-Inchima, Silvio; Roussel, Pascal

    2007-01-01

    Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus, ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA polymerase I synthesizes the ribosomal RNAs and this activity is cell cycle regulated. The nucleolus reveals the functional organization of the nucleus in which the compartmentation of the different steps of ribosome biogenesis is observed whereas the nucleolar machineries are in permanent exchange with the nucleoplasm and other nuclear bodies. After mitosis, nucleolar assembly is a time and space regulated process controlled by the cell cycle. In addition, by generating a large volume in the nucleus with apparently no RNA polymerase II activity, the nucleolus creates a domain of retention/sequestration of molecules normally active outside the nucleolus. Viruses interact with the nucleolus and recruit nucleolar proteins to facilitate virus replication. The nucleolus is also a sensor of stress due to the redistribution of the ribosomal proteins in the nucleoplasm by nucleolus disruption. The nucleolus plays several crucial functions in the nucleus: in addition to its function as ribosome factory of the cells it is a multifunctional nuclear domain, and nucleolar activity is linked with several pathologies. Perspectives on the evolution of this research area are proposed. PMID:18046571

  6. Technical Basis for Flood Protection at Nuclear Power Plants

    DTIC Science & Technology

    2015-07-01

    ER D C/ CH L SR -1 5- 3 Technical Basis for Flood Protection at Nuclear Power Plants Co as ta l a nd H yd ra ul ic s La bo ra to ry...2015 Technical Basis for Flood Protection at Nuclear Power Plants James R. Leech, Loren L. Wehmeyer, David A. Margo, Landris T. Lee, Aaron R. Byrd...39180-6199 ERDC/CHL SR-15-3 ii Abstract Current flood- protection regulatory guidance for nuclear power plants is contained in the Regulatory Guide

  7. Short-lived radionuclides in nuclear medicine - II

    SciTech Connect

    Budinger, T.F.; Peng, C.T.

    1985-11-01

    Positron emission tomography (PET) has been applied effectively in the diagnosis of Alzheimer's disease, the prognosis of stroke, and the evaluation of the efficacy of tumor therapy. In addition, PET has been applied to studies of the neuroreceptor distribution in the human brain, to studies of epilepsy and congenital disorders of the brain, and to the study of flow and metabolism of the human heart muscle. Of the many current investigations of PET, the three discussed here are now of clinical importance for patient care.

  8. Quantum chaos in the nuclear collective model. II. Peres lattices.

    PubMed

    Stránský, Pavel; Hruska, Petr; Cejnar, Pavel

    2009-06-01

    This is a continuation of our paper [Phys. Rev. E 79, 046202 (2009)] devoted to signatures of quantum chaos in the geometric collective model of atomic nuclei. We apply the method by Peres to study ordered and disordered patterns in quantum spectra drawn as lattices in the plane of energy vs average of a chosen observable. Good qualitative agreement with standard measures of chaos is manifested. The method provides an efficient tool for studying structural changes in eigenstates across quantum spectra of general systems.

  9. Monitoring the Durability Performance of Concrete in Nuclear Waste Containment. Technical Progress Report No. 3

    SciTech Connect

    Ulm, Franz-Josef

    2000-03-31

    OAK-B135 Monitoring the Durability Performance of Concrete in Nuclear Waste Containment. Technical Progress Report No. 3(NOTE: Part II A item 1 indicates ''PAPER'', but a report is attached electronically)

  10. PP2A Regulates HDAC4 Nuclear Import

    PubMed Central

    Paroni, Gabriela; Cernotta, Nadia; Dello Russo, Claudio; Gallinari, Paola; Pallaoro, Michele; Foti, Carmela; Talamo, Fabio; Orsatti, Laura; Steinkühler, Christian

    2008-01-01

    Different signal-regulated serine/threonine kinases phosphorylate class II histone deacetylases (HDACs) to promote nuclear export, cytosolic accumulation, and activation of gene transcription. However, little is known about mechanisms operating in the opposite direction, which, possibly through phosphatases, should promote class II HDACs nuclear entry and subsequent gene repression. Here we show that HDAC4 forms a complex with the PP2A holoenzyme Cα, Aα, B/PR55α. In vitro and in vivo binding studies demonstrate that the N-terminus of HDAC4 interacts with the catalytic subunit of PP2A. HDAC4 is dephosphorylated by PP2A and experiments using okadaic acid or RNA interference have revealed that PP2A controls HDAC4 nuclear import. Moreover, we identified serine 298 as a putative phosphorylation site important for HDAC4 nuclear import. The HDAC4 mutant mimicking phosphorylation of serine 298 is defective in nuclear import. Mutation of serine 298 to alanine partially rescues the defect in HDAC4 nuclear import observed in cells with down-regulated PP2A. These observations suggest that PP2A, via the dephosphorylation of multiple serines including the 14-3-3 binding sites and serine 298, controls HDAC4 nuclear import. PMID:18045992

  11. Nuclear charge and neutron radii and nuclear matter: Trend analysis in Skyrme density-functional-theory approach

    NASA Astrophysics Data System (ADS)

    Reinhard, P.-G.; Nazarewicz, W.

    2016-05-01

    Background: Radii of charge and neutron distributions are fundamental nuclear properties. They depend on both nuclear interaction parameters related to the equation of state of infinite nuclear matter and on quantal shell effects, which are strongly impacted by the presence of nuclear surface. Purpose: In this work, by studying the correlation of charge and neutron radii, and neutron skin, with nuclear matter parameters, we assess different mechanisms that drive nuclear sizes. Method: We apply nuclear density functional theory using a family of Skyrme functionals obtained by means of optimization protocols, which do not include any radius information. By performing the Monte Carlo sampling of reasonable functionals around the optimal parametrization, we scan all correlations between nuclear matter properties and observables characterizing charge and neutron distributions of spherical closed-shell nuclei 48Ca,208Pb, and 298Fl. Results: By considering the influence of various nuclear matter properties on charge and neutron radii in a multidimensional parameter space of Skyrme functionals, we demonstrate the existence of two strong relationships: (i) between the nuclear charge radii and the saturation density of symmetric nuclear matter ρ0, and (ii) between the neutron skins and the slope of the symmetry energy L . The impact of other nuclear matter properties on nuclear radii is weak or nonexistent. For functionals optimized to experimental binding energies only, proton and neutron radii are found to be weakly correlated due to canceling trends from different nuclear matter characteristics. Conclusion: The existence of only two strong relations connecting nuclear radii with nuclear matter properties has important consequences. First, by requiring that the nuclear functional reproduces the empirical saturation point of symmetric nuclear matter practically fixes the charge (or proton) radii, and vice versa. This explains the recent results of ab initio calculations

  12. Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading

    PubMed Central

    Li, Yuan; Lovett, David; Zhang, Qiao; Neelam, Srujana; Kuchibhotla, Ram Anirudh; Zhu, Ruijun; Gundersen, Gregg G.; Lele, Tanmay P.; Dickinson, Richard B.

    2015-01-01

    The nucleus has a smooth, regular appearance in normal cells, and its shape is greatly altered in human pathologies. Yet, how the cell establishes nuclear shape is not well understood. We imaged the dynamics of nuclear shaping in NIH3T3 fibroblasts. Nuclei translated toward the substratum and began flattening during the early stages of cell spreading. Initially, nuclear height and width correlated with the degree of cell spreading, but over time, reached steady-state values even as the cell continued to spread. Actomyosin activity, actomyosin bundles, microtubules, and intermediate filaments, as well as the LINC complex, were all dispensable for nuclear flattening as long as the cell could spread. Inhibition of actin polymerization as well as myosin light chain kinase with the drug ML7 limited both the initial spreading of cells and flattening of nuclei, and for well-spread cells, inhibition of myosin-II ATPase with the drug blebbistatin decreased cell spreading with associated nuclear rounding. Together, these results show that cell spreading is necessary and sufficient to drive nuclear flattening under a wide range of conditions, including in the presence or absence of myosin activity. To explain this observation, we propose a computational model for nuclear and cell mechanics that shows how frictional transmission of stress from the moving cell boundaries to the nuclear surface shapes the nucleus during early cell spreading. Our results point to a surprisingly simple mechanical system in cells for establishing nuclear shapes. PMID:26287620

  13. Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.

    PubMed

    Li, Yuan; Lovett, David; Zhang, Qiao; Neelam, Srujana; Kuchibhotla, Ram Anirudh; Zhu, Ruijun; Gundersen, Gregg G; Lele, Tanmay P; Dickinson, Richard B

    2015-08-18

    The nucleus has a smooth, regular appearance in normal cells, and its shape is greatly altered in human pathologies. Yet, how the cell establishes nuclear shape is not well understood. We imaged the dynamics of nuclear shaping in NIH3T3 fibroblasts. Nuclei translated toward the substratum and began flattening during the early stages of cell spreading. Initially, nuclear height and width correlated with the degree of cell spreading, but over time, reached steady-state values even as the cell continued to spread. Actomyosin activity, actomyosin bundles, microtubules, and intermediate filaments, as well as the LINC complex, were all dispensable for nuclear flattening as long as the cell could spread. Inhibition of actin polymerization as well as myosin light chain kinase with the drug ML7 limited both the initial spreading of cells and flattening of nuclei, and for well-spread cells, inhibition of myosin-II ATPase with the drug blebbistatin decreased cell spreading with associated nuclear rounding. Together, these results show that cell spreading is necessary and sufficient to drive nuclear flattening under a wide range of conditions, including in the presence or absence of myosin activity. To explain this observation, we propose a computational model for nuclear and cell mechanics that shows how frictional transmission of stress from the moving cell boundaries to the nuclear surface shapes the nucleus during early cell spreading. Our results point to a surprisingly simple mechanical system in cells for establishing nuclear shapes.

  14. Nuclear Energy and the Environment.

    ERIC Educational Resources Information Center

    International Atomic Energy Agency, Vienna (Austria).

    "Nuclear Energy and the Environment" is a pocket folder of removable leaflets concerned with two major topics: Nuclear energy and Nuclear Techniques. Under Nuclear Energy, leaflets concerning the topics of "Radiation--A Fact of Life,""The Impact of a Fact: 1963 Test Ban Treaty,""Energy Needs and Nuclear Power,""Power Reactor Safety,""Transport,"…

  15. Gordon Conference on Nuclear Research

    SciTech Connect

    Austin, S.M.

    1983-09-01

    Session topics were: quarks and nuclear physics; anomalons and anti-protons; the independent particle structure of nuclei; relativistic descriptions of nuclear structure and scattering; nuclear structure at high excitation; advances in nuclear astrophysics; properties of nuclear material; the earliest moments of the universe; and pions and spin excitations in nuclei.

  16. Nuclear fuel cycle information workshop

    SciTech Connect

    Not Available

    1983-01-01

    This overview of the nuclear fuel cycle is divided into three parts. First, is a brief discussion of the basic principles of how nuclear reactors work; second, is a look at the major types of nuclear reactors being used and world-wide nuclear capacity; and third, is an overview of the nuclear fuel cycle and the present industrial capability in the US.

  17. Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.

    PubMed

    Webster, Brant M; Thaller, David J; Jäger, Jens; Ochmann, Sarah E; Borah, Sapan; Lusk, C Patrick

    2016-11-15

    The integrity of the nuclear envelope barrier relies on membrane remodeling by the ESCRTs, which seal nuclear envelope holes and contribute to the quality control of nuclear pore complexes (NPCs); whether these processes are mechanistically related remains poorly defined. Here, we show that the ESCRT-II/III chimera, Chm7, is recruited to a nuclear envelope subdomain that expands upon inhibition of NPC assembly and is required for the formation of the storage of improperly assembled NPCs (SINC) compartment. Recruitment to sites of NPC assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2. We establish direct binding between Heh2 and the "open" forms of both Chm7 and the ESCRT-III, Snf7, and between Chm7 and Snf7. Interestingly, Chm7 is required for the viability of yeast strains where double membrane seals have been observed over defective NPCs; deletion of CHM7 in these strains leads to a loss of nuclear compartmentalization suggesting that the sealing of defective NPCs and nuclear envelope ruptures could proceed through similar mechanisms.

  18. Vented nuclear fuel element

    DOEpatents

    Grossman, Leonard N.; Kaznoff, Alexis I.

    1979-01-01

    A nuclear fuel cell for use in a thermionic nuclear reactor in which a small conduit extends from the outside surface of the emitter to the center of the fuel mass of the emitter body to permit escape of volatile and gaseous fission products collected in the center thereof by virtue of molecular migration of the gases to the hotter region of the fuel.

  19. Under the Nuclear Umbrella.

    ERIC Educational Resources Information Center

    Williams, Leon F.

    1987-01-01

    Entertains the thesis that social work has a stake in the technological-humanistic debate and should greet the recent and spectacular technological failures with protest and alarm. Discusses relationship of nuclear issue and social work, effects of nuclear issue on children, and Chernobyl. Advocates pacifism, activism, and a coherent conception of…

  20. Vertical nuclear proliferation.

    PubMed

    Sidel, Victor W

    2007-01-01

    All the nuclear-weapon states are working to develop new nuclear-weapon systems and upgrade their existing ones. Although the US Congress has recently blocked further development of small nuclear weapons and earth-penetrating nuclear weapons, the United States is planning a range of new warheads under the Reliable Replacement Warhead programme, and renewing its nuclear weapons infrastructure. The United Kingdom is spending 1 billion pounds sterling on updating the Atomic Weapons Establishment at Aldermaston, and about 20 billion pounds sterling on replacing its Vanguard submarines and maintaining its Trident warhead stockpile. The US has withdrawn from the Anti-Ballistic Missile Treaty and plans to install missile defence systems in Poland and the Czech Republic; Russia threatens to upgrade its nuclear countermeasures. The nuclear-weapon states should comply with their obligations under Article VI of the Non-Proliferation Treaty, as summarised in the 13-point plan agreed at the 2000 NPT Review Conference, and they should negotiate a Nuclear Weapons Convention.

  1. Nuclear physics and cosmology

    SciTech Connect

    Coc, Alain

    2014-05-09

    There are important aspects of Cosmology, the scientific study of the large scale properties of the universe as a whole, for which nuclear physics can provide insights. Here, we will focus on Standard Big-Bang Nucleosynthesis and we refer to the previous edition of the School [1] for the aspects concerning the variations of constants in nuclear cosmo-physics.

  2. Nuclear Taskforce Summation.

    ERIC Educational Resources Information Center

    1979

    At the end of 1978, there were approximately 230 nuclear-fueled electric generating plants around the world; 72 of these were in the United States. Each plant requires an operations-and-maintenance workforce of 92 people, and attrition occurs at a rate of 8% per year. Requirements for a nuclear taskforce and job training, in view of current…

  3. JPRS Report, Nuclear Developments

    DTIC Science & Technology

    2016-03-24

    7 Scientists Term Nuclear Reactor ’Satisfactory’ [XINHUA] ............................................................... 7 Neutron Velocity...PAULO 29 Oct] .................................... 14 Details of Secret Army Graphite Reactor Disclosed [FOLHA DE SAO PAULO 24 Oct] .............. 14...Corporation Plans To Expand Production [THE HINDU 2 Oct] .................................. 28 ISRAEL Request for Canadian Nuclear Reactor Confirmed

  4. Nuclear-Powered Debate.

    ERIC Educational Resources Information Center

    Arce, Gary

    1992-01-01

    Describes an exercise to develop interest and understanding about nuclear energy in which students make presentations regarding a proposal to build a hypothetical nuclear power plant. Students spend two weeks researching the topic; give testimony before a "Senate Energy Committee"; and vote on the proposal. Background information is…

  5. Talk About Nuclear Power

    ERIC Educational Resources Information Center

    Tremlett, Lewis

    1976-01-01

    Presents an overview of the relation of nuclear power to human health and the environment, and discusses the advantages and disadvantages of nuclear power as an energy source urging technical educators to inculcate an awareness of the problems associated with the production of energy. Describes the fission reaction process, the hazards of…

  6. Nuclear Age Education Curriculum.

    ERIC Educational Resources Information Center

    Oregon State Dept. of Education, Salem.

    The primary goal of the Oregon nuclear age education curriculum is to develop in students the knowledge and skills needed to meet the challenges of living in a nuclear age. This curriculum is developed around five general themes, each corresponding to a specific unit. The general goals for the units are: (Unit 1) to increase students' exposure to…

  7. Nuclear Power Plants. Revised.

    ERIC Educational Resources Information Center

    Lyerly, Ray L.; Mitchell, Walter, III

    This publication is one of a series of information booklets for the general public published by the United States Atomic Energy Commission. Among the topics discussed are: Why Use Nuclear Power?; From Atoms to Electricity; Reactor Types; Typical Plant Design Features; The Cost of Nuclear Power; Plants in the United States; Developments in Foreign…

  8. Nuclear Shuttle Logistics Configuration

    NASA Technical Reports Server (NTRS)

    1971-01-01

    This 1971 artist's concept shows the Nuclear Shuttle in both its lunar logistics configuraton and geosynchronous station configuration. As envisioned by Marshall Space Flight Center Program Development persornel, the Nuclear Shuttle would deliver payloads to lunar orbits or other destinations then return to Earth orbit for refueling and additional missions.

  9. High energy nuclear structures

    SciTech Connect

    Boguta, J.; Kunz, J.

    1984-03-09

    In conventional nuclear physics the nucleus is described as a non-relativistic many-body system, which is governed by the Schroedinger equation. Nucleons interact in this framework via static two-body potentials, mesonic degrees of freedom are neglected. An alternative description of nuclear physics in terms of a relativistic field theory has been developed by Walecka. The model Lagrangian containing baryons, sigma-mesons and ..omega..-mesons was subsequently extended to include also ..pi..-mesons and rho-mesons. An essential feature of such a nuclear Lagrangian is its renormalizability. In addition to the description of known nuclear structure the field theoretical approach may reveal entirely new nuclear phenomena, based on the explicit treatment of mesonic degrees of freedom. The existence of such abnormal nuclear states was proposed by Lee and Wick employing the sigma-model Lagrangian. There the non-linearity of the meson field equations allows for soliton solutions in the presence of nucleons, in particular the sigma-field may exhibit a kink. Different types of soliton solutions occur in gauge theories with hidden symmetries. In the phenomenological Lagrangian the rho-meson is described by a non-abelian gauge field, that acquires its mass spontaneously due to the non-vanishing vacuum expectation value of a Higgs field. A general ansatz for soliton solutions of such a gauge theory was given by Dashen et al. A specific solution and its possible implications for nuclear physics like anomalous nuclear states were discussed by Boguta.

  10. Nuclear Weapons and Schools.

    ERIC Educational Resources Information Center

    Howie, David I.

    1984-01-01

    The growing debate on nuclear weapons in recent years has begun to make inroads into school curricula. Elementary and secondary school teachers now face the important task of educating their students on issues relating to nuclear war without indoctrinating them to a particular point of view. (JBM)

  11. Nuclear effects at HERA

    SciTech Connect

    Brodsky, S.J.

    1996-07-01

    The development of a nuclear beam facility at HERA would allow the study of fundamental features of quark and gluon interactions in QCD. I briefly review the physics underlying nuclear shadowing and anti-shadowing as well as other diffractive and jet fragmentation processes that can be studies in high energy electron-nucleus collisions.

  12. TRAINING NUCLEAR TECHNICIANS.

    ERIC Educational Resources Information Center

    KOVNER, EDGAR A.

    PROBLEMS CONFRONTED BY PLANNERS OF NUCLEAR PROGRAMS AT THE TECHNICIAN LEVEL INCLUDE (1) LACK OF PRECEDENT IN CURRICULUM, COURSE OUTLINES, AND GRADUATE PLACEMENT, (2) DIFFICULTY IN DETERMINING COSTS OF LABORATORY CONSTRUCTION, EQUIPMENT, AND OPERATION, AND (3) REQUIREMENT OF ATOMIC ENERGY COMMISSION LICENSES IN NUCLEAR OCCUPATIONS. A 92-SEMESTER…

  13. Nuclear Power Plant Technician

    ERIC Educational Resources Information Center

    Randall, George A.

    1975-01-01

    The author recognizes a body of basic knowledge in nuclear power plant technoogy that can be taught in school programs, and lists the various courses, aiming to fill the anticipated need for nuclear-trained manpower--persons holding an associate degree in engineering technology. (Author/BP)

  14. Nuclear energy related research

    NASA Astrophysics Data System (ADS)

    Rintamaa, R.

    1992-05-01

    The annual Research Program Plan describes publicly funded nuclear energy related research to be carried out mainly at the Technical Research Center of Finland (VTT) in 1992. The research is financed primarily by the Ministry of Trade and Industry (KTM), the Finnish Center for Radiation and Nuclear Safety (STUK), and VTT itself. Other research institutes, utilities, and industry also contribute to many projects.

  15. World nuclear outlook 1994

    SciTech Connect

    1994-12-01

    As part of the EIA program to provide energy information, this analysis report presents the current status and projections through 2010 of nuclear capacity, generation, and fuel cycle requirements for all countries in the world using nuclear power to generate electricity for commercial use. It also contains information and forecasts of developments in the uranium market. Long-term projections of US nuclear capacity, generation, and spent fuel discharges for three different scenarios through 2040 are developed for the Department of Energy`s Office of Civilian Radioactive Waste Management (OCRWM). In turn, the OCRWM provides partial funding for preparation of this report. The projections of uranium requirements are provided to the Organization for Economic Cooperation and Development (OECD) for preparation of the Nuclear Energy Agency/OECD report, Summary of Nuclear Power and Fuel Cycle Data in OECD Member Countries.

  16. World nuclear outlook 1995

    SciTech Connect

    1995-09-29

    As part of the EIA program to provide energy information, this analysis report presents the current status and projections through 2015 of nuclear capacity, generation, and fuel cycle requirements for all countries in the world using nuclear power to generate electricity for commercial use. It also contains information and forecasts of developments in the uranium market. Long-term projections of US nuclear capacity, generation, and spent fuel discharges for two different scenarios through 2040 are developed for the Department of Energy`s Office of Civilian Radioactive Waste Management (OCRWM). In turn, the OCRWM provides partial funding for preparation of this report. The projections of uranium requirements are provided to the Organization for Economic Cooperation and Development (OECD) for preparation of the Nuclear Energy Agency/OECD report, Summary of Nuclear Power and Fuel Cycle Data in OECD Member Countries.

  17. Nuclear transfer in rodents.

    PubMed

    Mullins, Linda J; Wilmut, Ian; Mullins, John J

    2004-01-01

    Cloning is the asexual reproduction of an individual, such that the offspring have an essentially identical nuclear genome. Nuclear transfer and cloning have been achieved in a number of species, namely sheep, cows, goats, rabbits, cats and mice, but have been largely unsuccessful, so far, in dogs, primates and rats. Clearly, contributory factors which affect the outcome of successful cloning experiments are not universally applicable to all species. One theme common to all cloning experiments, however, is the overall inefficiency of the process, typically 0-4%. A number of factors contribute to nuclear transfer inefficiency, and we will review mouse cloning experiments, which address these problems, highlighting the importance of donor nucleus choice (somatic or ES cell, fetal or adult, quiescent or actively dividing). Finally, we will summarize the emerging principles which appear to govern nuclear reprogramming and production of clones, and will consider the application of nuclear transfer to the rat.

  18. Nuclear physics: Macroscopic aspects

    SciTech Connect

    Swiatecki, W.J.

    1993-12-01

    A systematic macroscopic, leptodermous approach to nuclear statics and dynamics is described, based formally on the assumptions {h_bar} {yields} 0 and b/R << 1, where b is the surface diffuseness and R the nuclear radius. The resulting static model of shell-corrected nuclear binding energies and deformabilities is accurate to better than 1 part in a thousand and yields a firm determination of the principal properties of the nuclear fluid. As regards dynamics, the above approach suggests that nuclear shape evolutions will often be dominated by dissipation, but quantitative comparisons with experimental data are more difficult than in the case of statics. In its simplest liquid drop version the model exhibits interesting formal connections to the classic astronomical problem of rotating gravitating masses.

  19. Nuclear Powerplant Safety: Source Terms. Nuclear Energy.

    ERIC Educational Resources Information Center

    Department of Energy, Washington, DC. Nuclear Energy Office.

    There has been increased public interest in the potential effects of nuclear powerplant accidents since the Soviet reactor accident at Chernobyl. People have begun to look for more information about the amount of radioactivity that might be released into the environment as a result of such an accident. When this issue is discussed by people…

  20. Nuclear war, nuclear proliferation, and their consequences

    SciTech Connect

    Sanruddin, A.K.

    1986-01-01

    The proceedings of a colloquium convened by the Groupe de Bellerive offers the contributions of Carl Sagan, Gabriel Garcia Marquez, Kenneth Galbraith, Pierre Trudeau, Edward Kennedy, and other eminent scientists, politicians, and strategists on the subject of the proliferation of nuclear weaponry and its potential ramifications.

  1. Nuclear excitation and precompound nuclear reactions

    SciTech Connect

    De, A.; Ray, S.; Ghosh, S.K.

    1988-06-01

    The angular distribution of nucleons emitted in nucleon-induced precompound nuclear reactions are calculated taking into account the effect of excitation on the kinematics of nucleon-nucleon scattering inside the target-plus-projectile system. The results are compared with quantum mechanical calculations and those of reaction models based on a pure nucleon-nucleon collision picture.

  2. US nuclear weapons policy

    SciTech Connect

    May, M.

    1990-12-05

    We are closing chapter one'' of the nuclear age. Whatever happens to the Soviet Union and to Europe, some of the major determinants of nuclear policy will not be what they have been for the last forty-five years. Part of the task for US nuclear weapons policy is to adapt its nuclear forces and the oganizations managing them to the present, highly uncertain, but not urgently competitive situation between the US and the Soviet Union. Containment is no longer the appropriate watchword. Stabilization in the face of uncertainty, a more complicated and politically less readily communicable goal, may come closer. A second and more difficult part of the task is to deal with what may be the greatest potential source of danger to come out of the end of the cold war: the breakup of some of the cooperative institutions that managed the nuclear threat and were created by the cold war. These cooperative institutions, principally the North Atlantic Treaty Organization (NATO), the Warsaw Pact, the US-Japan alliance, were not created specifically to manage the nuclear threat, but manage it they did. A third task for nuclear weapons policy is that of dealing with nuclear proliferation under modern conditions when the technologies needed to field effective nuclear weapons systems and their command and control apparatus are ever more widely available, and the leverage over some potential proliferators, which stemmed from superpower military support, is likely to be on the wane. This paper will make some suggestions regarding these tasks, bearing in mind that the unsettled nature of that part of the world most likely to become involved in nuclear weapons decisions today must make any suggestions tentative and the allowance for surprise more than usually important.

  3. Development of KURAMA-II and its operation in Fukushima

    NASA Astrophysics Data System (ADS)

    Tanigaki, M.; Okumura, R.; Takamiya, K.; Sato, N.; Yoshino, H.; Yoshinaga, H.; Kobayashi, Y.; Uehara, A.; Yamana, H.

    2015-05-01

    A carborne survey system, named as KURAMA (Kyoto University RAdiation MApping system), was developed as a response to the nuclear accident at TEPCO Fukushima Daiichi Nuclear Power Plant in 2011. Now the system has evolved into KURAMA-II, characterized by its compactness, autonomous operation, and acquisition of pulse-height spectrum data. A two-year field test of radiation monitoring by KURAMA-II on local buses, performed by Kyoto University, has successfully proceeded to the phase of official operation by the Fukushima prefectural government, supported by Kyoto University and JAEA (Japan Atomic Energy Agency). An outline and the current status of KURAMA-II, including some results of the continuous monitoring by KURAMA-II on local buses in Fukushima, are introduced.

  4. PREFACE: EPS Euroconference XIX Nuclear Physics Divisional Conference: New Trends in Nuclear Physics Applications and Technology

    NASA Astrophysics Data System (ADS)

    2006-06-01

    It was with great pleasure that the Department of Nuclear and Theoretical Physics of the University of Pavia and the INFN (Istituto Nazionale di Fisica Nucleare) Structure of Pavia organised the XIX Nuclear Physics Divisional Conference of the European Physical Society, which was held in the historical buildings of the University of Pavia from 5-9 September 2005. The Conference was devoted to the discussion of the most recent experimental and theoretical achievements in the field of Nuclear Physics applications, as well as of the latest developments in technological tools related to Nuclear Physics research. The University of Pavia has a long tradition in Physics and in Applied Physics, being the site where Alessandro Volta developed his "pila", the precursor of the modern battery. This is the place where the first experiments with electricity were conducted and where the term "capacitance" used for capacitors was invented. Today the University hosts a Triga Mark II nuclear reactor, which is used by the Departments of the University of Pavia and by other Universities and private companies as well. Moreover, Pavia is the site selected for the construction of the CNAO complex "Centro Nazionale di Adroterapia Oncologica" (National Centre for Oncological Hadrontherapy), planned for 2005-2008 which represents a unique facility in Italy and will be among the first complexes of this type in Europe. The Conference has gathered together experts in various fields from different countries and has been the occasion to review the present status and to discuss the new emerging trends in Nuclear Physics and its applications to multidisciplinary researches and the development of new technologies. The following topics were treated: Nuclear Techniques in Medicine and Life Sciences (Cancer Therapy, new Imaging and Diagnostics Tools, Radioisotope production, Radiation Protection and Dosimetry). Applications of Nuclear Techniques in Art, Archaeometry and other Interdisciplinary fields

  5. The nuclear dynamo; Can a nuclear tornado annihilate nations

    SciTech Connect

    McNally, J.R. Jr.

    1991-01-01

    This paper reports on the development of the hypothesis of a nuclear dynamo for a controlled nuclear fusion reactor. This dynamo hypothesis suggests properties for a nuclear tornado that could annihilate nations if accidentally triggered by a single high yield to weight nuclear weapon detonation. The formerly classified reports on ignition of the atmosphere, the properties of a nuclear dynamo, methods to achieve a nuclear dynamo in the laboratory, and the analogy of a nuclear dynamo to a nuclear tornado are discussed. An unclassified international study of this question is urged.

  6. 75 FR 39057 - Entergy Nuclear Operations, Inc.; Entergy Nuclear Vermont Yankee, LLC; Vermont Yankee Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc.; Entergy Nuclear Vermont Yankee, LLC; Vermont Yankee Nuclear... CFR), Section 2.206, ``Requests for Action under this Subpart,'' the U.S. Nuclear...

  7. 77 FR 7184 - Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc.; Indian Point Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc.; Indian Point Nuclear Generating Unit No. 2; Exemption 1.0 Background Entergy Nuclear Operations, Inc. (Entergy or the licensee)...

  8. 75 FR 3497 - Entergy Nuclear Operations, Inc., Entergy Nuclear Indian Point 2, LLC, Entergy Nuclear Indian...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc., Entergy Nuclear Indian Point 2, LLC, Entergy Nuclear Indian Point 3, LLC,: Indian Point Nuclear Generating Unit Nos. 2 and 3; Notice of Consideration of Issuance of Amendment to Facility Operating License...

  9. 76 FR 15001 - Entergy Nuclear Operations, Inc,. Entergy Nuclear Vermont Yankee, LLC, Vermont Yankee Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc,. Entergy Nuclear Vermont Yankee, LLC, Vermont Yankee Nuclear... Regulations (10 CFR) 2.206, ``Requests for Action under this Subpart,'' the U.S. Nuclear Regulatory...

  10. Atmospheric effects and societal consequences of regional scale nuclear conflicts and acts of individual nuclear terrorism

    NASA Astrophysics Data System (ADS)

    Toon, O. B.; Turco, R. P.; Robock, A.; Bardeen, C.; Oman, L.; Stenchikov, G. L.

    2007-04-01

    We assess the potential damage and smoke production associated with the detonation of small nuclear weapons in modern megacities. While the number of nuclear warheads in the world has fallen by about a factor of three since its peak in 1986, the number of nuclear weapons states is increasing and the potential exists for numerous regional nuclear arms races. Eight countries are known to have nuclear weapons, 2 are constructing them, and an additional 32 nations already have the fissile material needed to build substantial arsenals of low-yield (Hiroshima-sized) explosives. Population and economic activity worldwide are congregated to an increasing extent in megacities, which might be targeted in a nuclear conflict. We find that low yield weapons, which new nuclear powers are likely to construct, can produce 100 times as many fatalities and 100 times as much smoke from fires per kt yield as previously estimated in analyses for full scale nuclear wars using high-yield weapons, if the small weapons are targeted at city centers. A single "small" nuclear detonation in an urban center could lead to more fatalities, in some cases by orders of magnitude, than have occurred in the major historical conflicts of many countries. We analyze the likely outcome of a regional nuclear exchange involving 100 15-kt explosions (less than 0.1% of the explosive yield of the current global nuclear arsenal). We find that such an exchange could produce direct fatalities comparable to all of those worldwide in World War II, or to those once estimated for a "counterforce" nuclear war between the superpowers. Megacities exposed to atmospheric fallout of long-lived radionuclides would likely be abandoned indefinitely, with severe national and international implications. Our analysis shows that smoke from urban firestorms in a regional war would rise into the upper troposphere due to pyro-convection. Robock et al. (2007) show that the smoke would subsequently rise deep into the stratosphere due

  11. Your Radiologist Explains Nuclear Medicine

    MedlinePlus

    ... Sponsored by Image/Video Gallery Your Radiologist Explains Nuclear Medicine Transcript Welcome to Radiology Info dot org ... I’d like to talk to you about nuclear medicine. Nuclear medicine offers the potential to identify ...

  12. Supporting Our Nation's Nuclear Industry

    ScienceCinema

    Lyons, Peter

    2016-07-12

    On the 60th anniversary of the world's first nuclear power plant to produce electricity, Assistant Secretary for Nuclear Energy Peter Lyons discusses the Energy Department's and the Administration's commitment to promoting a nuclear renaissance in the United States.

  13. Your Radiologist Explains Nuclear Medicine

    MedlinePlus Videos and Cool Tools

    ... by Image/Video Gallery Your Radiologist Explains Nuclear Medicine Transcript Welcome to Radiology Info dot org Hello! ... d like to talk to you about nuclear medicine. Nuclear medicine offers the potential to identify disease ...

  14. Supporting Our Nation's Nuclear Industry

    SciTech Connect

    Lyons, Peter

    2011-01-01

    On the 60th anniversary of the world's first nuclear power plant to produce electricity, Assistant Secretary for Nuclear Energy Peter Lyons discusses the Energy Department's and the Administration's commitment to promoting a nuclear renaissance in the United States.

  15. Radiological Effects of Nuclear War.

    ERIC Educational Resources Information Center

    Shapiro, Charles S.

    1988-01-01

    Described are the global effects of nuclear war. Discussed are radiation dosages, limited nuclear attacks, strategic arms reductions, and other results reported at the workshop on nuclear war issues in Moscow in March 1988. (CW)

  16. "Fat Man and Little Boy": The Cinematic Representation of Interests in the Nuclear Weapons Organization.

    ERIC Educational Resources Information Center

    Taylor, Bryan C.

    1993-01-01

    Examines the ironic "problems" of the 1989 Hollywood film "Fat Man and Little Boy" (portraying the construction of the atomic bomb at the Los Alamos Laboratory during World War II) to demonstrate the ideological operations of nuclear texts, and the role of the nuclear weapons organization as a symbolic form in cultural…

  17. Independent nuclear state: the United States, Britain and the military atom

    SciTech Connect

    Simpson, J.

    1983-01-01

    Anglo-American relationships concerning nuclear weapons development from the World War II period up through the present are reviewed. The development of Great Britain as an independent nuclear state is examined in detail. The political factors affecting the cooperative efforts and alliances are discussed in detail as well as the trade in information and materials for reactor and weapons development.

  18. U.S.-China Strategic Dialogue, Phase II

    DTIC Science & Technology

    2007-04-12

    Chinese Presentation 12:00-1:30p Lunch – Hibiscus Suite (Kalia Tower-2nd floor) 1:30p Panel II: Crisis Escalation in Theory and History Paper...Lunch Hibiscus Suite (Kalia Tower-2nd floor) 1:30p Panel IV: Nuclear Weapons Safety and Security: Comparing national approaches and discussing... Hibiscus Suite (Kalia Tower-2nd floor) 25 APPENDIX II: CONFERENCE PARTICIPANTS 26 China Rear Admiral Yang Yi Director Institute of

  19. Photoreleasable ligands to study intracrine angiotensin II signalling

    PubMed Central

    Tadevosyan, Artavazd; Létourneau, Myriam; Folch, Benjamin; Doucet, Nicolas; Villeneuve, Louis R; Mamarbachi, Aida M; Pétrin, Darlaine; Hébert, Terence E; Fournier, Alain; Chatenet, David; Allen, Bruce G; Nattel, Stanley

    2015-01-01

    Several lines of evidence suggest that intracellular angiotensin II (Ang-II) contributes to the regulation of cardiac contractility, renal salt reabsorption, vascular tone and metabolism; however, work on intracrine Ang-II signalling has been limited to indirect approaches because of a lack of selective intracellularly-acting probes. Here, we aimed to synthesize and characterize cell-permeant Ang-II analogues that are inactive without uncaging, but release active Ang-II upon exposure to a flash of UV-light, and act as novel tools for use in the study of intracrine Ang-II physiology. We prepared three novel caged Ang-II analogues, [Tyr(DMNB)4]Ang-II, Ang-II-ODMNB and [Tyr(DMNB)4]Ang-II-ODMNB, based upon the incorporation of the photolabile moiety 4,5-dimethoxy-2-nitrobenzyl (DMNB). Compared to Ang-II, the caged Ang-II analogues showed 2–3 orders of magnitude reduced affinity toward both angiotensin type-1 (AT1R) and type-2 (AT2R) receptors in competition binding assays, and greatly-reduced potency in contraction assays of rat thoracic aorta. After receiving UV-irradiation, all three caged Ang-II analogues released Ang-II and potently induced the contraction of rat thoracic aorta. [Tyr(DMNB)4]Ang-II showed the most rapid photolysis upon UV-irradiation and was the focus of subsequent characterization. Whereas Ang-II and photolysed [Tyr(DMNB)4]Ang-II increased ERK1/2 phosphorylation (via AT1R) and cGMP production (AT2R), caged [Tyr(DMNB)4]Ang-II did not. Cellular uptake of [Tyr(DMNB)4]Ang-II was 4-fold greater than that of Ang-II and significantly greater than uptake driven by the positive-control HIV TAT(48–60) peptide. Intracellular photolysis of [Tyr(DMNB)4]Ang-II induced an increase in nucleoplasmic Ca2+ ([Ca2+]n), and initiated 18S rRNA and nuclear factor kappa B mRNA synthesis in adult cardiac cells. We conclude that caged Ang-II analogues represent powerful new tools for use in the selective study of intracrine signalling via Ang-II. PMID:25433071

  20. Dry Processing of Used Nuclear Fuel

    SciTech Connect

    K. M. Goff; M. F. Simpson

    2009-09-01

    Dry (non-aqueous) separations technologies have been used for treatment of used nuclear fuel since the 1960s, and they are still being developed and demonstrated in many countries. Dry technologies offer potential advantages compared to traditional aqueous separations including: compactness, resistance to radiation effects, criticality control benefits, compatibility with advanced fuel types, and ability to produce low purity products. Within the Department of Energy’s Advanced Fuel Cycle Initiative, an electrochemical process employing molten salts is being developed for recycle of fast reactor fuel and treatment of light water reactor oxide fuel to produce a feed for fast reactors. Much of the development of this technology is based on treatment of used Experimental Breeder Reactor II (EBR-II) fuel, which is metallic. Electrochemical treatment of the EBR-II fuel has been ongoing in the Fuel Conditioning Facility, located at the Materials and Fuel Complex of Idaho National Laboratory since 1996. More than 3.8 metric tons of heavy metal of metallic fast reactor fuel have been treated using this technology. This paper will summarize the status of electrochemical development and demonstration activities with used nuclear fuel, including high-level waste work. A historic perspective on the background of dry processing will also be provided.

  1. The new nuclear nations

    SciTech Connect

    Spector, L.

    1985-01-01

    Using 251 pages of text, 66 pages of references and 26 pages of appendixes, Spector delves into a world of new nuclear suppliers whose voracious hunger for profits may lead them to provide unwise assistance to countries that are unduly interested in nuclear weaponry. He assails a new dragon, a 'nuclear netherworld' that would illicitly supply such items for profit or political gain. Spector's book tells of covert dealings in nuclear technologies and materials. For him, the buyers have but one goal: '... to gain possession of the knowledge and materials necessary for development of nuclear weapons'. He warns of dangers from this illicit trade, of the loopholes in existing controls and the need to close them. His warnings come wrapped in stories of undercover transactions, many about Pakistan's efforts to get what it needs for its centrifuge enrichment plant. Recognizing the tightening of controls over nuclear trade since the 1970s, including those for dual-use items, Spector is nonetheless pessimistic that these efforts are sufficient to irradicate the nuclear netherworld or to deter newcomers from it.

  2. Nuclear forensics: Soil content

    SciTech Connect

    Beebe, Merilyn Amy

    2015-08-31

    Nuclear Forensics is a growing field that is concerned with all stages of the process of creating and detonating a nuclear weapon. The main goal is to prevent nuclear attack by locating and securing nuclear material before it can be used in an aggressive manner. This stage of the process is mostly paperwork; laws, regulations, treaties, and declarations made by individual countries or by the UN Security Council. There is some preliminary leg work done in the form of field testing detection equipment and tracking down orphan materials; however, none of these have yielded any spectacular or useful results. In the event of a nuclear attack, the first step is to analyze the post detonation debris to aid in the identification of the responsible party. This aspect of the nuclear forensics process, while reactive in nature, is more scientific. A rock sample taken from the detonation site can be dissolved into liquid form and analyzed to determine its chemical composition. The chemical analysis of spent nuclear material can provide valuable information if properly processed and analyzed. In order to accurately evaluate the results, scientists require information on the natural occurring elements in the detonation zone. From this information, scientists can determine what percentage of the element originated in the bomb itself rather than the environment. To this end, element concentrations in soils from sixty-nine different cities are given, along with activity concentrations for uranium, thorium, potassium, and radium in various building materials. These data are used in the analysis program Python.

  3. Evaluated Nuclear Data

    SciTech Connect

    Oblozinsky, P.; Oblozinsky,P.; Herman,M.; Mughabghab,S.F.

    2010-10-01

    This chapter describes the current status of evaluated nuclear data for nuclear technology applications. We start with evaluation procedures for neutron-induced reactions focusing on incident energies from the thermal energy up to 20 MeV, though higher energies are also mentioned. This is followed by examining the status of evaluated neutron data for actinides that play dominant role in most of the applications, followed by coolants/moderators, structural materials and fission products. We then discuss neutron covariance data that characterize uncertainties and correlations. We explain how modern nuclear evaluated data libraries are validated against an extensive set of integral benchmark experiments. Afterwards, we briefly examine other data of importance for nuclear technology, including fission yields, thermal neutron scattering and decay data. A description of three major evaluated nuclear data libraries is provided, including the latest version of the US library ENDF/B-VII.0, European JEFF-3.1 and Japanese JENDL-3.3. A brief introduction is made to current web retrieval systems that allow easy access to a vast amount of up-to-date evaluated nuclear data for nuclear technology applications.

  4. Perspectives of Nuclear Physics

    NASA Astrophysics Data System (ADS)

    Faessler, Amand

    2003-04-01

    The organizers of this meeting have asked me to present perspectives of nuclear physics. This means to identify the areas where nuclear physics will be expanding in the next future. In six chapters a short overview of these areas will be given, where I expect that nuclear physics will develop quite fast: (1) Quantum Chromodynamics and effective field theories in the confinement region. (2) Nuclear structure at the limits. (3) High energy heavy ion collisions. (4) Nuclear astrophysics. (5) Neutrino physics. (6) Test of physics beyond the standard model by rare processes. After a survey over these six points I will pick out a few topics where I will go more in details. There is no time to give for all six points detailed examples. I shall discuss the following examples of the six topics mentionned above: (1) The perturbative chiral quark model and the nucleon Σ-term. (2) VAMPIR (Variation After Mean field Projection In Realistic model spaces and with realistic forces) as an example of the nuclear structure renaissance. (3) Measurement of important astrophysical nuclear reactions in the Gamow peak. (4) The solar neutrino problem. As examples for testing new physics beyond the standard model by rare processes I had prepared to speak about the measurement of the electric neutron dipole moment and of the neutrinoless double beta decay. But the time is limited and so I have to skip these points, although they are extremely interesting.

  5. Virtual nuclear weapons

    SciTech Connect

    Pilat, J.F.

    1997-08-01

    The term virtual nuclear weapons proliferation and arsenals, as opposed to actual weapons and arsenals, has entered in recent years the American lexicon of nuclear strategy, arms control, and nonproliferation. While the term seems to have an intuitive appeal, largely due to its cyberspace imagery, its current use is still vague and loose. The author believes, however, that if the term is clearly delineated, it might offer a promising approach to conceptualizing certain current problems of proliferation. The first use is in a reference to an old problem that has resurfaced recently: the problem of growing availability of weapon-usable nuclear materials in civilian nuclear programs along with materials made `excess` to defense needs by current arms reduction and dismantlement. It is argued that the availability of these vast materials, either by declared nuclear-weapon states or by technologically advanced nonweapon states, makes it possible for those states to rapidly assemble and deploy nuclear weapons. The second use has quite a different set of connotations. It is derived conceptually from the imagery of computer-generated reality. In this use, one thinks of virtual proliferation and arsenals not in terms of the physical hardware required to make the bomb but rather in terms of the knowledge/experience required to design, assemble, and deploy the arsenal. Virtual weapons are a physics reality and cannot be ignored in a world where knowledge, experience, materials, and other requirements to make nuclear weapons are widespread, and where dramatic army reductions and, in some cases, disarmament are realities. These concepts are useful in defining a continuum of virtual capabilities, ranging from those at the low end that derive from general technology diffusion and the existence of nuclear energy programs to those at the high end that involve conscious decisions to develop or maintain militarily significant nuclear-weapon capabilities.

  6. Ovarian Cancer Stage II

    MedlinePlus

    ... Download Title: Ovarian Cancer Stage II Description: Three-panel drawing of stage IIA, IIB, and stage II primary peritoneal cancer; the first panel (stage IIA) shows cancer inside both ovaries that ...

  7. Factor II deficiency

    MedlinePlus

    ... if one or more of these factors are missing or are not functioning like they should. Factor II is one such coagulation factor. Factor II deficiency runs in families (inherited) and is very rare. Both parents must ...

  8. Nuclear Cryogenic Propulsion Stage

    NASA Technical Reports Server (NTRS)

    Houts, Michael G.; Borowski, S. K.; George, J. A.; Kim, T.; Emrich, W. J.; Hickman, R. R.; Broadway, J. W.; Gerrish, H. P.; Adams, R. B.

    2012-01-01

    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced NEP.

  9. Nuclear Regulatory Commission issuances

    SciTech Connect

    1996-03-01

    This document is the March 1996 listing of NRC issuances. Included are: (1) NRC orders granting Cleveland Electric Illuminating Company`s petition for review of the ASLB order LBP-95-17, (2) NRC orders relating to the potential disqualification of two commissioners in the matter of the decommissioning of Yankee Nuclear Power Station, (3) ASLB orders pertaining to the Oncology Services Corporation, (4) ASLB orders pertaining to the Radiation Oncology Center, (5) ASLB orders pertaining to the Yankee Nuclear Power Station, and (6) Director`s decision pertaining to the Yankee Nuclear Power Station.

  10. The nuclear option

    SciTech Connect

    Herken, G.

    1992-03-01

    A development history and current status evaluation are presented for nuclear-thermal rocket propulsion systems applicable to interplanetary flight. While the most advanced current chemical rocket engines, such as the SSMEs of the Space Shuttle, produce specific impulses of the order of 450 secs, a nuclear-thermal rocket engine tested at Los Alamos in 1969 generated 845 secs; such specific impulse improvements could represent weeks or months of interplanetary travel time. Attention is given to the achievements of the historical Nuclear Engine for Rocket Vehicle Application, Helios, and Orion design programs, as well as to the current Vehicle for Interplanetary Space Transportation Applications, which is fusion-based.

  11. Fictions of nuclear disaster

    SciTech Connect

    Dowling, D.

    1987-01-01

    This work is critical study of literary interpretations of the nuclear holocaust. The author examines more than 250 stories and novels dealing with the theme of nuclear power and its devastating potential implications. Addressing such topics as the scientist and Armageddon, the role of religion, future evolution and mutation, and the postnuclear society, the author assesses the response of Bradbury, Lessing, Malamud, Shute, Huxley, Vonnegut, Heinlein, and others to the threat of nuclear apocalypse, with in-depth analyses of Alter Miller's A canticle for Leibowitz and Russell Hoban's Riddley Walker.

  12. Monitoring international nuclear activity

    SciTech Connect

    Firestone, R.B.

    2006-05-19

    The LBNL Table of Isotopes website provides primary nuclearinformation to>150,000 different users annually. We have developedthe covert technology to identify users by IP address and country todetermine the kinds of nuclear information they are retrieving. Wepropose to develop pattern recognition software to provide an earlywarning system to identify Unusual nuclear activity by country or regionSpecific nuclear/radioactive material interests We have monitored nuclearinformation for over two years and provide this information to the FBIand LLNL. Intelligence is gleaned from the website log files. Thisproposal would expand our reporting capabilities.

  13. Nuclear Medicine Annual, 1989

    SciTech Connect

    Freeman, L.M.; Weissmann, H.S.

    1989-01-01

    Among the highlights of Nuclear Medicine Annual, 1989 are a status report on the thyroid scan in clinical practice, a review of functional and structural brain imaging in dementia, an update on radionuclide renal imaging in children, and an article outlining a quality assurance program for SPECT instrumentation. Also included are discussions on current concepts in osseous sports and stress injury scintigraphy and on correlative magnetic resonance and radionuclide imaging of bone. Other contributors assess the role of nuclear medicine in clinical decision making and examine medicolegal and regulatory aspects of nuclear medicine.

  14. TRUPACT-II Operating and Maintenance Instructions

    SciTech Connect

    Westinghouse Electric Corporation, Waste Isolation Division

    1999-12-31

    The purpose of this document is to provide the technical requirements for preparation for use, operation, inspection, and maintenance of a Transuranic Package Transporter Model II (TRUPACT-II) Shipping Package and directly related components. This document complies with the minimum requirements as specified in the TRUPACT-II Safety Analysis Report for Packaging (SARP) and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9218. In the event there is a conflict between this document and the TRUPACT-II SARP, the TRUPACT-II SARP shall govern. TRUPACT-II C of C number 9218 states, ''... each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application.'' It further states, ''... each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the application.'' Chapter 9 of the TRUPACT-II SARP charges the Westinghouse Electric Corporation Waste Isolation Division (WID) with assuring that the TRUPACT-II is used in accordance with the requirements of the C of C. To meet this requirement and verify consistency of operations when loading and unloading the TRUPACT-II on the trailer, placing a payload in the packaging, unloading the payload from the packaging, or performing maintenance, the U.S. Department of Energy Carlsbad Area Office (U.S. DOE/CAO) finds it necessary to implement the changes that follow. This TRUPACT-II maintenance document represents a change to previous philosophy regarding site specific procedures for the use of the TRUPACT-II. This document details the instructions to be followed to consistently operate and maintain the TRUPACT-II. The intent of these instructions is to ensure that all users of the TRUPACT-II follow the same or equivalent instructions. Users may achieve this intent by any of the following methods: (1) Utilizing these instructions as is, or (2

  15. Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescence.

    PubMed

    Han, Ying-Hao; Kwon, Jeong-Hoon; Yu, Dae-Yeul; Moon, Eun-Yi

    2006-11-01

    Intracellular reactive oxygen species (ROS) were attenuated by the expression of peroxiredoxin II (Prx II). Cellular senescence as judged by senescence-associated (SA)-beta-galactosidase (Gal) positive cell formation was increased in Prx II-deficient mouse embryonic fibroblast (MEF). Ras expression was increased following passages. The level of Ras expression was higher in Prx II-/- MEF than wild type MEF. ERK activity was also augmented by the deletion of Prx II. SA-beta-Gal-positive cell formation was reduced by PD98059, ERK inhibitor. Activated nuclear transcription factor, nuclear factor-kappaB (NFkappaB) by the deletion of Prx II was inhibited by the treatment with PD98059. In contrast, no changes in SA-beta-Gal-positive cell formation were detected by NFkappaB inhibitor, N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK). Collectively, results suggest that Prx II deletion activate Ras-ERK-NFkappaB pathways and cellular senescence in Prx II-/- MEF cells was mediated by ERK activation but not by NFkappaB activation.

  16. An integrated mechanism of cardiomyocyte nuclear Ca(2+) signaling.

    PubMed

    Ibarra, Cristián; Vicencio, Jose Miguel; Varas-Godoy, Manuel; Jaimovich, Enrique; Rothermel, Beverly A; Uhlén, Per; Hill, Joseph A; Lavandero, Sergio

    2014-10-01

    In cardiomyocytes, Ca(2+) plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical functions is achieved by segregating Ca(2+) within subcellular microdomains: transcription is regulated by Ca(2+) release within nuclear microdomains, and excitation-contraction coupling is regulated by cytosolic Ca(2+). Accordingly, a variety of agonists that control cardiomyocyte gene expression, such as endothelin-1, angiotensin-II or insulin-like growth factor-1, share the feature of triggering nuclear Ca(2+) signals. However, signaling pathways coupling surface receptor activation to nuclear Ca(2+) release, and the phenotypic responses to such signals, differ between agonists. According to earlier hypotheses, the selective control of nuclear Ca(2+) signals by activation of plasma membrane receptors relies on the strategic localization of inositol trisphosphate receptors at the nuclear envelope. There, they mediate Ca(2+) release from perinuclear Ca(2+) stores upon binding of inositol trisphosphate generated in the cytosol, which diffuses into the nucleus. More recently, identification of such receptors at nuclear membranes or perinuclear sarcolemmal invaginations has uncovered novel mechanisms whereby agonists control nuclear Ca(2+) release. In this review, we discuss mechanisms for the selective control of nuclear Ca(2+) signals with special focus on emerging models of agonist receptor activation.

  17. An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling

    PubMed Central

    Ibarra, Cristián; Vicencio, Jose Miguel; Varas-Godoy, Manuel; Jaimovich, Enrique; Rothermel, Beverly A.; Uhlén, Per; Hill, Joseph A.; Lavandero, Sergio

    2015-01-01

    In cardiomyocytes, Ca2+ plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical functions is achieved by segregating Ca2+ within subcellular microdomains: transcription is regulated by Ca2+ release within nuclear microdomains, and excitation–contraction coupling is regulated by cytosolic Ca2+. Accordingly, a variety of agonists that control cardiomyocyte gene expression, such as endothelin-1, angiotensin-II or insulin-like growth factor-1, share the feature of triggering nuclear Ca2+ signals. However, signaling pathways coupling surface receptor activation to nuclear Ca2+ release, and the phenotypic responses to such signals, differ between agonists. According to earlier hypotheses, the selective control of nuclear Ca2+ signals by activation of plasma membrane receptors relies on the strategic localization of inositol trisphosphate receptors at the nuclear envelope. There, they mediate Ca2+ release from perinuclear Ca2+ stores upon binding of inositol trisphosphate generated in the cytosol, which diffuses into the nucleus. More recently, identification of such receptors at nuclear membranes or perinuclear sarcolemmal invaginations has uncovered novel mechanisms whereby agonists control nuclear Ca2+ release. In this review, we discuss mechanisms for the selective control of nuclear Ca2+ signals with special focus on emerging models of agonist receptor activation. PMID:24997440

  18. Nuclear space power safety and facility guidelines study

    SciTech Connect

    Mehlman, W.F.

    1995-09-11

    This report addresses safety guidelines for space nuclear reactor power missions and was prepared by The Johns Hopkins University Applied Physics Laboratory (JHU/APL) under a Department of Energy grant, DE-FG01-94NE32180 dated 27 September 1994. This grant was based on a proposal submitted by the JHU/APL in response to an {open_quotes}Invitation for Proposals Designed to Support Federal Agencies and Commercial Interests in Meeting Special Power and Propulsion Needs for Future Space Missions{close_quotes}. The United States has not launched a nuclear reactor since SNAP 10A in April 1965 although many Radioisotope Thermoelectric Generators (RTGs) have been launched. An RTG powered system is planned for launch as part of the Cassini mission to Saturn in 1997. Recently the Ballistic Missile Defense Office (BMDO) sponsored the Nuclear Electric Propulsion Space Test Program (NEPSTP) which was to demonstrate and evaluate the Russian-built TOPAZ II nuclear reactor as a power source in space. As of late 1993 the flight portion of this program was canceled but work to investigate the attributes of the reactor were continued but at a reduced level. While the future of space nuclear power systems is uncertain there are potential space missions which would require space nuclear power systems. The differences between space nuclear power systems and RTG devices are sufficient that safety and facility requirements warrant a review in the context of the unique features of a space nuclear reactor power system.

  19. Nuclear Fuel Reprocessing

    SciTech Connect

    Michael F. Simpson; Jack D. Law

    2010-02-01

    This is an a submission for the Encyclopedia of Sustainable Technology on the subject of Reprocessing Spent Nuclear Fuel. No formal abstract was required for the article. The full article will be attached.

  20. Nuclear Explosion Monitoring

    SciTech Connect

    Fagan, Deborah K.; Anderson, Dale N.; Shumway, Robert

    2008-09-15

    Teleseismic events (earthquakes or explosions) generate strong seismic energy waves that propagate largely in the mantle. For example, the Threshold Test Ban Treaty restricted nuclear tests to be less that 150 kilotons in size, and explosions of this size generate seismic energy waves that are observed teleseismically. Teleseismic monitoring for explosions answers three questions: Where is the seismic event located? Is the event an explosion or natural (event identification)? If an explosion, how large was it? Resolving whether an explosion is chemical or nuclear can require additional analysis (e.g., analysis of atmospherically observed chemical and nuclear spectra). Because of the political ramifications of event identification errors, risk analysis in the context of nuclear explosion monitoring is unique.

  1. Children's (Pediatric) Nuclear Medicine

    MedlinePlus

    ... nuclear medicine facility. Through the natural process of radioactive decay, the small amount of radiotracer in your child’s body will lose its radioactivity over time. In many cases, the radioactivity will ...

  2. 2011 Japanese Nuclear Incident

    EPA Pesticide Factsheets

    EPA’s RadNet system monitored the environmental radiation levels in the United States and parts of the Pacific following the Japanese Nuclear Incident. Learn about EPA’s response and view historical laboratory data and news releases.

  3. Desalting and Nuclear Energy

    ERIC Educational Resources Information Center

    Burwell, Calvin C.

    1971-01-01

    Future use of nuclear energy to produce electricity and desalted water is outlined. Possible desalting processes are analyzed to show economic feasibility and the place in planning in world's economic growth. (DS)

  4. Nuclear Heart Scan

    MedlinePlus

    ... into your blood and travels to your heart. Nuclear heart scans use single photon emission computed tomography (SPECT) or cardiac positron emission tomography (PET) to detect the energy from the tracer to make pictures of your ...

  5. International Nuclear Security

    SciTech Connect

    Doyle, James E.

    2012-08-14

    This presentation discusses: (1) Definitions of international nuclear security; (2) What degree of security do we have now; (3) Limitations of a nuclear security strategy focused on national lock-downs of fissile materials and weapons; (4) What do current trends say about the future; and (5) How can nuclear security be strengthened? Nuclear security can be strengthened by: (1) More accurate baseline inventories; (2) Better physical protection, control and accounting; (3) Effective personnel reliability programs; (4) Minimize weapons-usable materials and consolidate to fewer locations; (5) Consider local threat environment when siting facilities; (6) Implement pledges made in the NSS process; and (7) More robust interdiction, emergency response and special operations capabilities. International cooperation is desirable, but not always possible.

  6. The nuclear weapons world

    SciTech Connect

    Burke, P.

    1988-01-01

    This book presents insight into the technical world of weapons production. It discusses accountability in nuclear weapons decisionmaking. Nuclear decisions and the weapons and strategy they concern are too mammoth, too complex and too intimidating a subject for most of us to grapple with. The more so because informed debate is rare, and because information is difficult to obtain. In Britain, Parliamentary questions receive evasive answers or no answers at all, and the rationale of official secrecy is used as a reason to reveal less and less about decisions on national defense: between 1981 and 1987, for example, the number of open government documents published on defence fell from fifty-seven to two. In the case of NATO, decisions on nuclear strategy into the next century are taken in secret by defence ministers meeting in the Nuclear Planning Group.

  7. Physics and nuclear power

    NASA Astrophysics Data System (ADS)

    Buttery, N. E.

    2008-03-01

    Nuclear power owes its origin to physicists. Fission was demonstrated by physicists and chemists and the first nuclear reactor project was led by physicists. However as nuclear power was harnessed to produce electricity the role of the engineer became stronger. Modern nuclear power reactors bring together the skills of physicists, chemists, chemical engineers, electrical engineers, mechanical engineers and civil engineers. The paper illustrates this by considering the Sizewell B project and the role played by physicists in this. This covers not only the roles in design and analysis but in problem solving during the commissioning of first of a kind plant. Looking forward to the challenges to provide sustainable and environmentally acceptable energy sources for the future illustrates the need for a continuing synergy between physics and engineering. This will be discussed in the context of the challenges posed by Generation IV reactors.

  8. Nuclear energy: moving ahead

    SciTech Connect

    Not Available

    1983-01-01

    Electricity is assuming a larger role despite conservation efforts because it can be generated from a variety of fuels, it is essential for many industrial processes, and it is easier to control the environmental impacts from centralized power plants. The growth in electricity use over the next 10 years is expected to match that of productivity and the gross national product. After examining available energy sources and concluding that nuclear energy is necessary for an adequate and reliable supply, this booklet goes on to examine the risks, accidents and accident control, safety research, nuclear waste management, and the economics of nuclear energy. It concludes that nuclear energy is needed for both the transition period as fossil fuels are used up and in the long term when demand may increase as much as 50%. 24 references, 5 figures, 1 table.

  9. Nuclear data interface retrospective

    SciTech Connect

    Gray, Mark G

    2008-01-01

    The Nuclear Data Interface (NDI) code library and data formats are the standards for multigroup nuclear data at Los Alamos National Laboratory. NDI's analysis, design, implementation, testing, integration, and maintenance required a ten person-year and ongoing effort by the Nuclear Data Team. Their efforts provide a unique, contemporary experience in producing a standard component library. In reflection upon that experience at NDI's decennial, we have identified several factors critical to NDI's success: it addressed real problems with appropriate simplicity, it fully supported all users, it added extra value through the code to the raw nuclear data, and its team went the distance from analysis through maintenance. In this report we review these critical success factors and discuss their implications for future standardization projects.

  10. JPRS report, nuclear developments

    SciTech Connect

    1991-03-28

    This report contains articles concerning the nuclear developments of the following countries: (1) China; (2) Japan, North Korea, South Korea; (3) Bulgaria; (4) Argentina, Brazil, Honduras; (5) India, Iran, Pakistan, Syria; (6) Soviet Union; and (7) France, Germany, Turkey.

  11. Nuclear material operations manual

    SciTech Connect

    Tyler, R.P.

    1981-02-01

    This manual provides a concise and comprehensive documentation of the operating procedures currently practiced at Sandia National Laboratories with regard to the management, control, and accountability of nuclear materials. The manual is divided into chapters which are devoted to the separate functions performed in nuclear material operations-management, control, accountability, and safeguards, and the final two chapters comprise a document which is also issued separately to provide a summary of the information and operating procedures relevant to custodians and users of radioactive and nuclear materials. The manual also contains samples of the forms utilized in carrying out nuclear material activities. To enhance the clarity of presentation, operating procedures are presented in the form of playscripts in which the responsible organizations and necessary actions are clearly delineated in a chronological fashion from the initiation of a transaction to its completion.

  12. Direct nuclear pumped laser

    DOEpatents

    Miley, George H.; Wells, William E.; DeYoung, Russell J.

    1978-01-01

    There is provided a direct nuclear pumped gas laser in which the lasing mechanism is collisional radiated recombination of ions. The gas laser active medium is a mixture of the gases, with one example being neon and nitrogen.

  13. Nuclear Clusters in Astrophysics

    NASA Astrophysics Data System (ADS)

    Kubono, S.; Binh, Dam N.; Hayakawa, S.; Hashimoto, H.; Kahl, D.; Wakabayashi, Y.; Yamaguchi, H.; Teranishi, T.; Iwasa, N.; Komatsubara, T.; Kato, S.; Khiem, Le H.

    2010-03-01

    The role of nuclear clustering is discussed for nucleosynthesis in stellar evolution with Cluster Nucleosynthesis Diagram (CND) proposed before. Special emphasis is placed on α-induced stellar reactions together with molecular states for O and C burning.

  14. Western Nuclear Science Alliance

    SciTech Connect

    Steve Reese; George Miller; Stephen Frantz; Denis Beller; Denis Beller; Ed Morse; Melinda Krahenbuhl; Bob Flocchini; Jim Elliston

    2010-12-07

    The primary objective of the INIE program is to strengthen nuclear science and engineering programs at the member institutions and to address the long term goal of the University Reactor Infrastructure and Education Assistance Program.

  15. Structural Biology of Nuclear Auxin Action.

    PubMed

    Dinesh, Dhurvas Chandrasekaran; Villalobos, Luz Irina A Calderón; Abel, Steffen

    2016-04-01

    Auxin coordinates plant development largely via hierarchical control of gene expression. During the past decades, the study of early auxin genes paired with the power of Arabidopsis genetics have unraveled key nuclear components and molecular interactions that perceive the hormone and activate primary response genes. Recent research in the realm of structural biology allowed unprecedented insight into: (i) the recognition of auxin-responsive DNA elements by auxin transcription factors; (ii) the inactivation of those auxin response factors by early auxin-inducible repressors; and (iii) the activation of target genes by auxin-triggered repressor degradation. The biophysical studies reviewed here provide an impetus for elucidating the molecular determinants of the intricate interactions between core components of the nuclear auxin response module.

  16. Nuclear Technology Series. Course 5: Introduction to Nuclear Systems.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  17. Nuclear Technology Series. Course 24: Nuclear Systems and Safety.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  18. Nuclear Technology Series. Course 23: Nuclear Chemical Processes.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  19. Nuclear fuel element

    DOEpatents

    Meadowcroft, Ronald Ross; Bain, Alastair Stewart

    1977-01-01

    A nuclear fuel element wherein a tubular cladding of zirconium or a zirconium alloy has a fission gas plenum chamber which is held against collapse by the loops of a spacer in the form of a tube which has been deformed inwardly at three equally spaced, circumferential positions to provide three loops. A heat resistant disc of, say, graphite separates nuclear fuel pellets within the cladding from the plenum chamber. The spacer is of zirconium or a zirconium alloy.

  20. UNISOR Nuclear Orientation Facility

    SciTech Connect

    Girit, I.C.

    1988-01-01

    The combination of an on-line isotope separator and a dilution refrigerator has increased the applicability of the nuclear orientation technique to a wide range of nuclei, especially those very far from stability. The UNISOR Nuclear Orientation Facility (UNISOR/NOF) is among the two (the other being NICOLE at CERN) that have recently become operational. The following is an overall view of the UNISOR system and recent results. 24 refs., 3 figs.

  1. Nuclear magnetic resonance gyroscope

    SciTech Connect

    Grover, B.C.

    1984-02-07

    A nuclear magnetic resonance gyro using two nuclear magnetic resonance gases, preferably xenon 129 and xenon 131, together with two alkaline metal vapors, preferably rubidium, potassium or cesium, one of the two alkaline metal vapors being pumped by light which has the wavelength of that alkaline metal vapor, and the other alkaline vapor being illuminated by light which has the wavelength of that other alkaline vapor.

  2. Keeping Nuclear Materials Secure

    SciTech Connect

    2016-10-19

    For 50 years, Los Alamos National Laboratory has been helping to keep nuclear materials secure. We do this by developing instruments and training inspectors that are deployed to other countries to make sure materials such as uranium are being used for peaceful purposes and not diverted for use in weapons. These measures are called “nuclear safeguards,” and they help make the world a safer place.

  3. Nuclear Warfare Water Contamination.

    DTIC Science & Technology

    1982-05-01

    Products x Applied Health Physics, Inc x Applied Physical Technology, Inc x Aptec Nuclear Inc x The Aston Company x Baird Corp x Berthold-Beta...15, Department of the Army, Washington, D. C., June 1966. 61 26. Private Communication, D. C. Lindsten (USAMERADCOM) to John C.Phillips (SA[-Chicago...Detection and Measurement," John Wiley & Sons, New York, 1919. 29. Lichholz, G. G., "Environmental Aspects of Nuclear Power," Ann Arbor, Science, Ann Arbor

  4. Nuclear Plant Inspection

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Engineers from the Power Authority of the State of New York use a Crack Growth Analysis Program supplied by COSMIC (Computer Software Management and Information Center) in one stage of nuclear plant inspection. Welds of the nuclear steam supply system are checked for cracks; radiographs, dye penetration and visual inspections are performed to locate cracks in the metal structure and welds. The software package includes three separate crack growth analysis models and enables necessary repairs to be planned before serious problems develop.

  5. Nuclear Rocket Technology Conference

    NASA Technical Reports Server (NTRS)

    1966-01-01

    The Lewis Research Center has a strong interest in nuclear rocket propulsion and provides active support of the graphite reactor program in such nonnuclear areas as cryogenics, two-phase flow, propellant heating, fluid systems, heat transfer, nozzle cooling, nozzle design, pumps, turbines, and startup and control problems. A parallel effort has also been expended to evaluate the engineering feasibility of a nuclear rocket reactor using tungsten-matrix fuel elements and water as the moderator. Both of these efforts have resulted in significant contributions to nuclear rocket technology. Many successful static firings of nuclear rockets have been made with graphite-core reactors. Sufficient information has also been accumulated to permit a reasonable Judgment as to the feasibility of the tungsten water-moderated reactor concept. We therefore consider that this technoIogy conference on the nuclear rocket work that has been sponsored by the Lewis Research Center is timely. The conference has been prepared by NASA personnel, but the information presented includes substantial contributions from both NASA and AEC contractors. The conference excludes from consideration the many possible mission requirements for nuclear rockets. Also excluded is the direct comparison of nuclear rocket types with each other or with other modes of propulsion. The graphite reactor support work presented on the first day of the conference was partly inspired through a close cooperative effort between the Cleveland extension of the Space Nuclear Propulsion Office (headed by Robert W. Schroeder) and the Lewis Research Center. Much of this effort was supervised by Mr. John C. Sanders, chairman for the first day of the conference, and by Mr. Hugh M. Henneberry. The tungsten water-moderated reactor concept was initiated at Lewis by Mr. Frank E. Rom and his coworkers. The supervision of the recent engineering studies has been shared by Mr. Samuel J. Kaufman, chairman for the second day of the

  6. Nuclear Fuel Cycle

    SciTech Connect

    Dale, Deborah J.

    2014-10-28

    These slides will be presented at the training course “International Training Course on Implementing State Systems of Accounting for and Control (SSAC) of Nuclear Material for States with Small Quantity Protocols (SQP),” on November 3-7, 2014 in Santa Fe, New Mexico. The slides provide a basic overview of the Nuclear Fuel Cycle. This is a joint training course provided by NNSA and IAEA.

  7. JPRS Report, Nuclear Developments.

    DTIC Science & Technology

    2007-11-02

    COMERCIO 21 Aug] 23 NEAR EAST & SOUTH ASIA EGYPT Agreements Signed to Develop Domestic Uranium [AL-JUMHURIYAH 2 Aug] 24 INDIA Two Large...Empresas Nucleares Brasileiras S.A. (Nuclebras) to Industrias Nucleares do Brasil S.A. (INB), and trans- ferred the shares of its capital stock...96.622 authorizes the establishment of Uranium of Brasil S.A. as a subsidiary of INB, with headquarters in the city of Caldas, Minas Gerais State

  8. Nuclear Energy Policy

    DTIC Science & Technology

    2007-07-12

    Generation IV Program will also focus on developing a sodium-cooled fast reactor ( SFR ). Existing U.S. commercial nuclear reactors use water to slow...Nevada. The UREX+ process also would reduce the heat generated by nuclear waste — the major limit on the repository’s capacity — by removing cesium ...significantly contaminated by radioactive cesium .17 Greenpeace issued a report in 2006 estimating that 200,000 deaths in Belarus, Russia, and Ukraine resulted

  9. Management of Global Nuclear Materials for International Security

    SciTech Connect

    Isaacs, T; Choi, J-S

    2003-09-18

    Nuclear materials were first used to end the World War II. They were produced and maintained during the cold war for global security reasons. In the succeeding 50 years since the Atoms for Peace Initiative, nuclear materials were produced and used in global civilian reactors and fuel cycles intended for peaceful purposes. The Nonproliferation Treaty (NPT) of 1970 established a framework for appropriate applications of both defense and civilian nuclear activities by nuclear weapons states and non-nuclear weapons states. As global inventories of nuclear materials continue to grow, in a diverse and dynamically changing manner, it is time to evaluate current and future trends and needed actions: what are the current circumstances, what has been done to date, what has worked and what hasn't? The aim is to identify mutually reinforcing programmatic directions, leading to global partnerships that measurably enhance international security. Essential elements are material protection, control and accountability (MPC&A) of separated nuclear materials, interim storage, and geologic repositories for all nuclear materials destined for final disposal. Cooperation among key partners, such as the MPC&A program between the U.S. and Russia for nuclear materials from dismantled weapons, is necessary for interim storage and final disposal of nuclear materials. Such cooperative partnerships can lead to a new nuclear regime where a complete fuel cycle service with fuel leasing and spent fuel take-back can be offered to reactor users. The service can effectively minimize or even eliminate the incentive or rationale for the user-countries to develop their indigenous enrichment and reprocessing technologies. International cooperation, supported by governments of key countries can be best to facilitate the forum for formation of such cooperative partnerships.

  10. Superpower nuclear minimalism

    SciTech Connect

    Graben, E.K.

    1992-01-01

    During the Cold War, the United States and the Soviet Union competed in building weapons -- now it seems like America and Russia are competing to get rid of them the fastest. The lengthy process of formal arms control has been replaced by exchanges of unilateral force reductions and proposals for reciprocal reductions not necessarily codified by treaty. Should superpower nuclear strategies change along with force postures President Bush has yet to make a formal pronouncement on post-Cold War American nuclear strategy, and it is uncertain if the Soviet/Russian doctrine of reasonable sufficiency formulated in the Gorbachev era actually heralds a change in strategy. Some of the provisions in the most recent round of unilateral proposals put forth by Presidents Bush and Yeltsin in January 1992 are compatible with a change in strategy. Whether such a change has actually occurred remains to be seen. With the end of the Cold War and the breakup of the Soviet Union, the strategic environment has fundamentally changed, so it would seem logical to reexamine strategy as well. There are two main schools of nuclear strategic thought: a maximalist school, mutual assured destruction (MAD) which emphasizes counterforce superiority and nuclear war- fighting capability, and a MAD-plus school, which emphasizes survivability of an assured destruction capability along with the ability to deliver small, limited nuclear attacks in the event that conflict occurs. The MAD-plus strategy is based on an attempt to conventionalize nuclear weapons which is unrealistic.

  11. Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesis

    PubMed Central

    Hyter, Stephen; Indra, Arup K

    2013-01-01

    Skin homeostasis is maintained, in part, through regulation of gene expression orchestrated by type II nuclear hormone receptors in a cell and context specific manner. This group of transcriptional regulators is implicated in various cellular processes including epidermal proliferation, differentiation, permeability barrier formation, follicular cycling and inflammatory responses. Endogenous ligands for the receptors regulate actions during skin development and maintenance of tissue homeostasis. Type II nuclear receptor signaling is also important for cellular crosstalk between multiple cell types in the skin. Overall, these nuclear receptors are critical players in keratinocyte and melanocyte biology and present targets for cutaneous disease management. PMID:23395795

  12. 10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been...

  13. 10 CFR 140.85 - Criterion II-Substantial damages to persons offsite or property offsite.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 140.85 Section 140.85 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) FINANCIAL PROTECTION REQUIREMENTS AND INDEMNITY AGREEMENTS Extraordinary Nuclear Occurrences § 140.85 Criterion...

  14. 10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been...

  15. 10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been...

  16. 10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been...

  17. 10 CFR 840.5 - Criterion II-Substantial damages to persons offsite or property offsite.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Criterion II-Substantial damages to persons offsite or property offsite. 840.5 Section 840.5 Energy DEPARTMENT OF ENERGY EXTRAORDINARY NUCLEAR OCCURRENCES § 840.5... nuclear, or byproduct material; or (2) DOE finds that $2,500,000 or more of damage offsite has been...

  18. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. . Dept. of Chemical and Nuclear Engineering)

    1992-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz 11 space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safely assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the US with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  19. A Nuclear Energy Renaissance: Challenges to Nuclear Weapon Nonproliferation

    DTIC Science & Technology

    2009-03-30

    civilian nuclear power infrastructure. Light water reactors require enriched uranium to operate, albeit at much lower enrichment percentages...the horizon. Twenty-two years after the Chernobyl nuclear reactor accident the world’s nuclear energy industry is booming.1 Nuclear energy is...experiencing a strong revival around the world and in the United States. There are currently 439 nuclear reactors operating worldwide, in 30 countries. Thirty

  20. Analysis of nuclear reconstitution, nuclear envelope assembly, and nuclear pore assembly using Xenopus in vitro assays.

    PubMed

    Bernis, Cyril; Forbes, Douglass J

    2014-01-01

    The large and complex eukaryotic nucleus is the arbiter of DNA replication, RNA transcription, splicing, and ribosome assembly. With the advent of in vitro nuclear reconstitution extracts derived from Xenopus eggs in the 1980s, it became possible to assemble multiple nuclei in vitro around added DNA or chromatin substrates. Such reconstituted nuclei contain a nuclear lamina, double nuclear membranes, nuclear pores, and are competent for DNA replication and nuclear import. In vitro nuclear reconstitution has allowed the assembly of "wild-type" and "biochemically mutant" nuclei in which the impact of individual components can be assessed. Here, we describe protocols for preparation of the nuclear reconstitution extract, nuclear reconstitution in vitro, assessment of nuclear membrane integrity, and a more specialized assay for nuclear pore assembly into preformed pore-free nuclear intermediates.

  1. Analysis of Nuclear Reconstitution, Nuclear Envelope Assembly, and Nuclear Pore Assembly Using Xenopus In Vitro Assays

    PubMed Central

    Bernis, Cyril; Forbes, Douglass J.

    2015-01-01

    The large and complex eukaryotic nucleus is the arbiter of DNA replication, RNA transcription, splicing, and ribosome assembly. With the advent of in vitro nuclear reconstitution extracts derived from Xenopus eggs in the 1980s, it became possible to assemble multiple nuclei in vitro around added DNA or chromatin substrates. Such reconstituted nuclei contain a nuclear lamina, double nuclear membranes, nuclear pores, and are competent for DNA replication and nuclear import. In vitro nuclear reconstitution has allowed the assembly of “wild-type” and “biochemically mutant” nuclei in which the impact of individual components can be assessed. Here, we describe protocols for preparation of the nuclear reconstitution extract, nuclear reconstitution in vitro, assessment of nuclear membrane integrity, and a more specialized assay for nuclear pore assembly into preformed pore-free nuclear intermediates. PMID:24857730

  2. Type II oestrogen binding sites in human colorectal carcinoma.

    PubMed Central

    Piantelli, M; Ricci, R; Larocca, L M; Rinelli, A; Capelli, A; Rizzo, S; Scambia, G; Ranelletti, F O

    1990-01-01

    Seven cases of colorectal adenocarcinomas were investigated for the presence of oestrogen receptors and progesterone receptors. The tumours specifically bound oestradiol. This binding almost exclusively resulted from the presence of high numbers of type II oestrogen binding sites. Oestrogen receptors were absent or present at very low concentrations. Immunohistochemical investigation of nuclear oestrogen receptors gave negative results. This indicates that antioestrogen receptor antibodies recognise oestrogen receptors but not type II oestrogen binding sites. The presence of specific type II oestrogen binding sites and progesterone binding offers further evidence for a potential role for these steroids and their receptors in colorectal carcinoma. PMID:2266171

  3. Uterine type II estrogen-binding sites are not of eosinophil origin

    SciTech Connect

    Not Available

    1986-01-05

    A recent report suggested that nuclear type II sites in the rat uterus are of eosinophil origin and may represent (/sup 3/H)estradiol binding to eosinophil peroxidase. To further evaluate this hypothesis the authors examined the response of nuclear type II sites to estrogen under conditions where eosinophils are not present. Results of the experiments show that physiological levels of estradiol-17..beta.. (10 nM for 72 h) will stimulate nuclear type II sites in highly purified cultures of rat uterine stromal and myometrial cells. The magnitude of the response of type II sites to estradiol in these stromal (4-fold) and myometrial (80-fold) cell cultures was essentially identical to that observed in the uterine cell types following in vivo estrogen treatment. Since these highly purified cultures of uterine cells were prepared from the uterus of a 21-day ovariectomized rat which is devoid of eosinophils, it was concluded that estradiol stimulation of nuclear type II sites is a direct intracellular response to estrogen which occurs independent of eosinophil accumulation. Furthermore, it was found that type II sites in the rat uterus are not peroxidase. Stimulation of cytosol and nuclear type II sites by estrogen in the rat uterus is a direct intracellular response to the hormone unrelated to eosinophil accumulation and/or peroxidase activity.

  4. Panel report: nuclear physics

    SciTech Connect

    Carlson, Joseph A; Hartouni, Edward P

    2010-01-01

    Nuclear science is at the very heart of the NNSA program. The energy produced by nuclear processes is central to the NNSA mission, and nuclear reactions are critical in many applications, including National Ignition Facility (NIF) capsules, energy production, weapons, and in global threat reduction. Nuclear reactions are the source of energy in all these applications, and they can also be crucial in understanding and diagnosing the complex high-energy environments integral to the work of the NNSA. Nuclear processes are complex quantum many-body problems. Modeling and simulation of nuclear reactions and their role in applications, coupled tightly with experiments, have played a key role in NNSA's mission. The science input to NNSA program applications has been heavily reliant on experiment combined with extrapolations and physical models 'just good enough' to provide a starting point to extensive engineering that generated a body of empirical information. This body of information lacks the basic science underpinnings necessary to provide reliable extrapolations beyond the domain in which it was produced and for providing quantifiable error bars. Further, the ability to perform additional engineering tests is no longer possible, especially those tests that produce data in the extreme environments that uniquely characterize these applications. The end of testing has required improvements to the predictive capabilities of codes simulating the reactions and associated applications for both well known and well characterized cases as well as incompletely known cases. Developments in high performance computing, computational physics, applied mathematics and nuclear theory have combined to make spectacular advances in the theory of fission, fusion and nuclear reactions. Current research exploits these developments in a number of Office of Science and NNSA programs, and in joint programs such as the SciDAC (Science Discovery through Advanced Computing) that supports the

  5. Thinking About Preventing Nuclear War.

    ERIC Educational Resources Information Center

    Ground Zero, Washington, DC.

    Potential paths to nuclear war and the available means of prevention of nuclear war are discussed. Presented is a detailed description of six nuclear war scenarios, and brief examples of types of potential deterrents to nuclear war (firebreaks) which are relevant for each. To be effective, the right combination of firebreaks must be used, the…

  6. Nuclear War and Science Teaching.

    ERIC Educational Resources Information Center

    Hobson, Art

    1983-01-01

    Suggests that science-related material on nuclear war be included in introductory courses. Lists nuclear war topics for physics, psychology, sociology, biology/ecology, chemistry, geography, geology/meteorology, mathematics, and medical science. Also lists 11 lectures on nuclear physics which include nuclear war topics. (JN)

  7. Uncertainties in nuclear fission data

    NASA Astrophysics Data System (ADS)

    Talou, Patrick; Kawano, Toshihiko; Chadwick, Mark B.; Neudecker, Denise; Rising, Michael E.

    2015-03-01

    We review the current status of our knowledge of nuclear fission data, and quantify uncertainties related to each fission observable whenever possible. We also discuss the roles that theory and experiment play in reducing those uncertainties, contributing to the improvement of our fundamental understanding of the nuclear fission process as well as of evaluated nuclear data libraries used in nuclear applications.

  8. Britain`s nuclear quandary

    SciTech Connect

    1994-07-01

    This article is review of energy policy in the United Kingdom, in particular, the British government`s review of the nuclear industry. Major topics of this review include: (1) The economic viability of new nuclear stations, (2) The privitization of the nuclear industry, (3) Nuclear waste disposal, and (4) Liabilities associated with decommissioning.

  9. Nuclear and Non-Nuclear Airblast Effects.

    DTIC Science & Technology

    1984-02-14

    Military Applications of Blast Simulation (1974). 5. Pyatt, K., CSB Review Meeting, DNA Hadquarters, October 13, 1982. .4. 54 °." .4,% * APPENDIX C... systematically larger. (ii) In the regular reflection region (underneath and close to the fireball), the HE case exhibits two overpressure peaks at the...1.t is clear that the major cualitative features persist loncest in the velocity plots. This is not surprising, as the circulation patterns

  10. Nuclear powerplants for mobile applications.

    NASA Technical Reports Server (NTRS)

    Anderson, J. L.

    1972-01-01

    Mobile nuclear powerplants for applications other than large ships and submarines will require compact, lightweight reactors with especially stringent impact-safety design. This paper examines the technical and economic feasibility that the broadening role of civilian nuclear power, in general, (land-based nuclear electric generating plants and nuclear ships) can extend to lightweight, safe mobile nuclear powerplants. The paper discusses technical experience, identifies potential sources of technology for advanced concepts, cites the results of economic studies of mobile nuclear powerplants, and surveys future technical capabilities needed by examining the current use and projected needs for vehicles, machines, and habitats that could effectively use mobile nuclear reactor powerplants.

  11. Stockpile Stewardship: How we Ensure the Nuclear Deterrent without Testing

    ScienceCinema

    None

    2016-07-12

    In the 1990s, the U.S. nuclear weapons program shifted emphasis from developing new designs to dismantling thousands of existing weapons and maintaining a much smaller enduring stockpile. The United States ceased underground nuclear testing, and the Department of Energy created the Stockpile Stewardship Program to maintain the safety, security, and reliability of the U.S. nuclear deterrent without full-scale testing. This video gives a behind the scenes look at a set of unique capabilities at Lawrence Livermore that are indispensable to the Stockpile Stewardship Program: high performance computing, the Superblock category II nuclear facility, the JASPER a two stage gas gun, the High Explosive Applications Facility (HEAF), the National Ignition Facility (NIF), and the Site 300 contained firing facility.

  12. Stockpile Stewardship: How we Ensure the Nuclear Deterrent without Testing

    SciTech Connect

    2014-09-04

    In the 1990s, the U.S. nuclear weapons program shifted emphasis from developing new designs to dismantling thousands of existing weapons and maintaining a much smaller enduring stockpile. The United States ceased underground nuclear testing, and the Department of Energy created the Stockpile Stewardship Program to maintain the safety, security, and reliability of the U.S. nuclear deterrent without full-scale testing. This video gives a behind the scenes look at a set of unique capabilities at Lawrence Livermore that are indispensable to the Stockpile Stewardship Program: high performance computing, the Superblock category II nuclear facility, the JASPER a two stage gas gun, the High Explosive Applications Facility (HEAF), the National Ignition Facility (NIF), and the Site 300 contained firing facility.

  13. The A-bomb, 50 years later: The evolution of nuclear medicine

    SciTech Connect

    Kotz, D.

    1995-08-01

    In the wake of the Hiroshima and Nagasaki bombings, the U.S. government began to invest heavily in its nuclear program. Nuclear medicine stood to gain from these postwar policies, but it also suffered some setbacks. Fifty years ago this month, two atomic bombs were dropped on Japan, killing thousands of civilians and ushering in a quick and final end to World War II. The beginning of the post-war era signaled the birth of nuclear medicine as it is widely applied today. In fact, the same nuclear reactor that produced elements for the A-bomb project was turned over for the mass production of radionuclides for medicine and industry. The link between the A-bomb and nuclear medicine, however, has always been a sensitive subject among nuclear physicians whose patients may associate radionuclide injections with mushroom clouds. Although this link is not justified, the government`s interest in developing nuclear technology following World War II did have a significant impact on nuclear medicine: on the upside, millions of federal dollars were funneled into the production of radionuclides for research and medicine. On the downside, Congress established the Atomic Energy Commission (AEC)-which later became the Nuclear Regulatory Commission (NRC)-to oversee safety issues, making nuclear medicine the only medical field regulated by a federal agency.

  14. International academic program in technologies of light-water nuclear reactors. Phases of development and implementation

    NASA Astrophysics Data System (ADS)

    Geraskin, N. I.; Glebov, V. B.

    2017-01-01

    The results of implementation of European educational projects CORONA and CORONA II dedicated to preserving and further developing nuclear knowledge and competencies in the area of technologies of light-water nuclear reactors are analyzed. Present article addresses issues of design and implementation of the program for specialized training in the branch of technologies of light-water nuclear reactors. The systematic approach has been used to construct the program for students of nuclear specialties, which corresponding to IAEA standards and commonly accepted nuclear principles recognized in the European Union. Possibilities of further development of the international cooperation between countries and educational institutions are analyzed. Special attention is paid to e-learning/distance training, nuclear knowledge preservation and interaction with European Nuclear Education Network.

  15. 78 FR 50458 - Entergy Nuclear Operations, Inc., James A. Fitzpatrick Nuclear Power Plant, Vermont Yankee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Entergy Nuclear Operations, Inc., James A. Fitzpatrick Nuclear Power Plant, Vermont Yankee Nuclear Power Station, Pilgrim Nuclear Power Station, Request for Action AGENCY: Nuclear Regulatory...

  16. Nuclear Regulatory Commission information digest

    SciTech Connect

    None,

    1990-03-01

    The Nuclear Regulatory Commission information digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the commission. This is an annual publication for the general use of the NRC Staff and is available to the public. The digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  17. Atmospheric effects and societal consequences of regional scale nuclear conflicts and acts of individual nuclear terrorism

    NASA Astrophysics Data System (ADS)

    Toon, O. B.; Turco, R. P.; Robock, A.; Bardeen, C.; Oman, L.; Stenchikov, G. L.

    2006-11-01

    We assess the potential damage and smoke production associated with the detonation of small nuclear weapons in modern megacities. While the number of nuclear warheads in the world has fallen by about a factor of three since its peak in 1986, the number of nuclear weapons states is increasing and the potential exists for numerous regional nuclear arms races. Eight countries are known to have nuclear weapons, 2 are constructing them, and an additional 32 nations already have the fissile material needed to build substantial arsenals of low-yield (Hiroshima-sized) explosives. Population and economic activity worldwide are congregated to an increasing extent in megacities, which might be targeted in a nuclear conflict. Our analysis shows that, per kiloton of yield, low yield weapons can produce 100 times as many fatalities and 100 times as much smoke from fires as high-yield weapons, if they are targeted at city centers. A single "small'' nuclear detonation in an urban center could lead to more fatalities, in some cases by orders of magnitude, than have occurred in the major historical conflicts of many countries. We analyze the likely outcome of a regional nuclear exchange involving 100 15-kt explosions (less than 0.1% of the explosive yield of the current global nuclear arsenal). We find that such an exchange could produce direct fatalities comparable to all of those worldwide in World War II, or to those once estimated for a "counterforce'' nuclear war between the superpowers. Megacities exposed to atmospheric fallout of long-lived radionuclides would likely be abandoned indefinitely, with severe national and international implications. Our analysis shows that smoke from urban firestorms in a regional war would rise into the upper troposphere due to pyro-convection. Robock et al. (2006) show that the smoke would subsequently rise deep into the stratosphere due to atmospheric heating, and then might induce significant climatic anomalies on global scales.We also

  18. 40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 11 2012-07-01 2012-07-01 false Volatile Organic HAP (VOHAP) Limits... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP... 571 728 Mist 610 2,235 Navigational aids 550 1,597 Nonskid 340 571 728 Nuclear 420 841 1,069...

  19. 40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 11 2013-07-01 2013-07-01 false Volatile Organic HAP (VOHAP) Limits... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP... 571 728 Mist 610 2,235 Navigational aids 550 1,597 Nonskid 340 571 728 Nuclear 420 841 1,069...

  20. 40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Volatile Organic HAP (VOHAP) Limits... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP... 571 728 Mist 610 2,235 Navigational aids 550 1,597 Nonskid 340 571 728 Nuclear 420 841 1,069...