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Sample records for anos uma narrativa

  1. ANO1 — EDRN Public Portal

    Cancer.gov

    ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.

  2. Ano1 as a regulator of proliferation

    PubMed Central

    Stanich, Jennifer E.; Gibbons, Simon J.; Eisenman, Seth T.; Bardsley, Michael R.; Rock, Jason R.; Harfe, Brian D.; Ordog, Tamas

    2011-01-01

    Ano1 is a recently discovered Ca2+-activated Cl− channel expressed on interstitial cells of Cajal (ICC) that has been implicated in slow-wave activity in the gut. However, Ano1 is expressed on all classes of ICC, even those that do not contribute to generation of the slow wave, suggesting that Ano1 may have an alternate function in these cells. Ano1 is also highly expressed in gastrointestinal stromal tumors. Mice lacking Ano1 had fewer proliferating ICC in whole mount preparations and in culture, raising the possibility that Ano1 is involved in proliferation. Cl− channel blockers decreased proliferation in cells expressing Ano1, including primary cultures of ICC and in the pancreatic cancer-derived cell line, CFPAC-1. Cl− channel blockers had a reduced effect on Ano1(−/−) cultures, confirming that the blockers are acting on Ano1. Ki67 immunoreactivity, 5-ethynyl-2′-deoxyuridine incorporation, and cell-cycle analysis of cells grown in low-Cl− media showed fewer proliferating cells than in cultures grown in regular medium. We confirmed that mice lacking Ano1 had less phosphorylated retinoblastoma protein compared with controls. These data led us to conclude that Ano1 regulates proliferation at the G1/S transition of the cell cycle and may play a role in tumorigenesis. PMID:21940901

  3. Idiopathic fistula-in-ano

    PubMed Central

    Shawki, Sherief; Wexner, Steven D

    2011-01-01

    Fistula-in-ano is the most common form of perineal sepsis. Typically, a fistula includes an internal opening, a track, and an external opening. The external opening might acutely appear following infection and/or an abscess, or more insiduously in a chronic manner. Management includes control of infection, assessment of the fistulous track in relation to the anal sphincter muscle, and finally, definitive treatment of the fistula. Fistulotomy was the most commonly used mode of management, but concerns about post-fistulotomy incontinence prompted the use of sphincter preserving techniques such as advancement flaps, fibrin glue, collagen fistula plug, ligation of the intersphincteric fistula track, and stem cells. Many descriptive and comparative studies have evaluated these different techniques with variable outcomes. The lack of consistent results, level I evidence, or long-term follow-up, as well as the heterogeneity of fistula pathology has prevented a definitive treatment algorithm. This article will review the most commonly available modalities and techniques for managing idiopathic fistula-in-ano. PMID:21876614

  4. Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells.

    PubMed

    Cherkashin, Alexander P; Kolesnikova, Alisa S; Tarasov, Michail V; Romanov, Roman A; Rogachevskaja, Olga A; Bystrova, Marina F; Kolesnikov, Stanislav S

    2016-02-01

    Specialized Ca(2+)-dependent ion channels ubiquitously couple intracellular Ca(2+) signals to a change in cell polarization. The existing physiological evidence suggests that Ca(2+)-activated Cl(-) channels (CaCCs) are functional in taste cells. Because Ano1 and Ano2 encode channel proteins that form CaCCs in a variety of cells, we analyzed their expression in mouse taste cells. Transcripts for Ano1 and Ano2 were detected in circumvallate (CV) papillae, and their expression in taste cells was confirmed using immunohistochemistry. When dialyzed with CsCl, taste cells of the type III exhibited no ion currents dependent on cytosolic Ca(2+). Large Ca(2+)-gated currents mediated by TRPM5 were elicited in type II cells by Ca(2+) uncaging. When TRPM5 was inhibited by triphenylphosphine oxide (TPPO), ionomycin stimulated a small but resolvable inward current that was eliminated by anion channel blockers, including T16Ainh-A01 (T16), a specific Ano1 antagonist. This suggests that CaCCs, including Ano1-like channels, are functional in type II cells. In type I cells, CaCCs were prominently active, blockable with the CaCC antagonist CaCCinh-A01 but insensitive to T16. By profiling Ano1 and Ano2 expressions in individual taste cells, we revealed Ano1 transcripts in type II cells only, while Ano2 transcripts were detected in both type I and type II cells. P2Y agonists stimulated Ca(2+)-gated Cl(-) currents in type I cells. Thus, CaCCs, possibly formed by Ano2, serve as effectors downstream of P2Y receptors in type I cells. While the role for TRPM5 in taste transduction is well established, the physiological significance of expression of CaCCs in type II cells remains to be elucidated.

  5. Learning about the Sky from the Environment: An Experience Working Along One Year with Students of Elementary Education. (Spanish Title: Aprendiendo sobre EL Cielo Desde el Entorno: Una Experiencia Trabajando Durante un Año Junto a Estudiantes del Primario.) Aprendendo sobre o Céu a Partir do Entorno: Uma Experiência de Trabalho ao Longo de um Ano com Alunos de Ensino Fundamental

    NASA Astrophysics Data System (ADS)

    Longhini, Marcos Daniel; Gomide, Hanny Angeles

    2014-12-01

    percepción limitada que los estudiantes tienen de su alrededor la cual, sin embargo, se expandió debido a las actividades llevadas a cabo, sobre todo en relación con la Luna. Trabajar con medidas sistemáticas revela el manejo cuidadoso de los datos para que sean comprensibles para los estudiantes, así como el trabajo con las sombras para que comprendan primero como se forman estas para después trabajarlas en Astronomía. Por último, llegamos a la conclusión de que el proceso desarrollado consistió en una etapa inicial de una obra que debe ser profundizado en los años posteriores de la formación de estos estudiantes. Projeto de pesquisa desenvolvido com 95 alunos do 6º ano do Ensino Fundamental de uma escola pública estadual de Uberlândia, Minas Gerais. Foi um trabalho contínuo, de fevereiro a dezembro de 2013, o qual levou os alunos a participarem de atividades de observação do entorno, dentre ele, o céu, analisando as mudanças ocorridas. Focamos no estudo das variações de temperaturas, chuvas, duração do dia, variações do tamanho das sombras e mudanças nos aspectos da Lua. Nosso foco de análise centrou-se em discutir os conhecimentos que os referidos alunos tinham acerca dos temas indicados no início e ao término da implementação da proposta. Os resultados mostraram a percepção limitada que os estudantes possuem de seu entorno, todavia, ampliada em função das atividades desenvolvidas, principalmente no que se refere à Lua. O trabalho com medidas sistemáticas revela o cuidado no tratamento dos dados para que eles se tornem compreensíveis aos alunos, assim como o trabalho com as sombras sinaliza para que os alunos primeiramente compreendam como as sombras são formadas para depois trabalhar isso em Astronomia. Por fim, concluímos que o processo vivido constituiu-se em uma etapa inicial de um trabalho que deve ser estimulado para os anos subsequentes da formação desses alunos.

  6. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2

    PubMed Central

    Seo, Yohan; Lee, Ho K.; Park, Jinhong; Jeon, Dong-kyu; Jo, Sungwoo; Jo, Minjae; Namkung, Wan

    2016-01-01

    Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression. To date, only a few ANO1 inhibitors have been described, and these have low potency and selectivity for ANO1. Here, we performed a high-throughput screening to identify highly potent and selective small molecule inhibitors of ANO1. Three novel ANO1 inhibitors were discovered from screening of 54,400 synthetic small molecules, and they were found to fully block ANO1 channel activity with an IC50 < 3 μM. Electrophysiological analysis revealed that the most potent inhibitor, 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), completely inhibited ANO1 chloride current with submicromolar potency. Notably, unlike previous small-molecule ANO1 inhibitors identified to date, Ani9 displayed high selectivity for ANO1 as compared to ANO2, which shares a high amino acid homology to ANO1. In addition, Ani9 did not affect the intracellular calcium signaling and CFTR chloride channel activity. Our results suggest that Ani9 may be a useful pharmacological tool for studying ANO1 and a potential development candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma. PMID:27219012

  7. A normal ano-genital exam: sexual abuse or not?

    PubMed

    Hornor, Gail

    2010-01-01

    Sexual abuse is a problem of epidemic proportions in the United States. Pediatric nurse practitioners (PNPs) are at the forefront of providing care to children and families. The PNP is in a unique position to educate patients and families regarding sexual abuse and dispel common myths associated with sexual abuse. One such myth is that a normal ano-genital examination is synonymous with the absence of sexual abuse. This article will provide primary care providers, including PNPs, with a framework for understanding why a normal ano-genital examination does not negate the possibility of sexual abuse/assault. Normal ano-genital anatomy, changes that occur with puberty, and physical properties related to the genitalia and anus will be discussed. Photos will provide visualization of both normal variants of the pre-pubertal hymen and genitalia as well as changes that occur with puberty. Implications for practice for PNPs will be discussed.

  8. Magnetic resonance imaging for primary fistula in ano.

    PubMed

    Buchanan, G N; Halligan, S; Williams, A B; Cohen, C R G; Tarroni, D; Phillips, R K S; Bartram, C I

    2003-07-01

    This was a prospective study designed to determine the therapeutic impact of magnetic resonance imaging (MRI) in primary fistula in ano, and to assess its effect on outcome. Thirty patients with suspected primary fistula in ano underwent preoperative MRI, and the findings were revealed during surgery following examination under anaesthesia (EUA). Any effect on operative approach was noted. Outcome was assessed at a median of 12 months. Two patients had sinuses, one had no sepsis and 27 had fistulas: five superficial, seven intersphincteric, 14 trans-sphincteric and one suprasphincteric. MRI and EUA agreed in 15 patients and MRI findings altered the surgical approach in a further three (10 per cent); two of the latter patients were believed to have a sinus at EUA, which MRI correctly identified as a fistula, allowing definitive treatment. The therapeutic impact of MRI was therefore 10 per cent. Persisting disagreement between MRI and EUA in 12 patients mostly related to minor discrepancies in classification. Only one patient required further unplanned surgery, which was for skin-bridging rather than any new sepsis. In experienced hands, MRI has a therapeutic impact of 10 per cent for primary fistula in ano, precipitating surgery that is likely to reduce recurrence in a small, but important, proportion of patients. Copyright 2003 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

  9. Uma Krishnaswami and International Imaginings

    ERIC Educational Resources Information Center

    Aldama, Frederick Luis

    2006-01-01

    This article presents an interview with South Asian children's book and young adult fiction writer, Uma Krishnaswami. The interviewer states that "in all her creative endeavors Uma's keen sense of detail, narrative voice, and characterization complicate and humanize portrayals of multicultural peoples worldwide." In this interview, Krishnaswami…

  10. Experimental porcine model of complex fistula-in-ano

    PubMed Central

    A Ba-Bai-Ke-Re, Ma-Mu-Ti-Jiang; Chen, Hui; Liu, Xue; Wang, Yun-Hai

    2017-01-01

    AIM To establish and evaluate an experimental porcine model of fistula-in-ano. METHODS Twelve healthy pigs were randomly divided into two groups. Under general anesthesia, the experimental group underwent rubber band ligation surgery, and the control group underwent an artificial damage technique. Clinical magnetic resonance imaging (MRI) and histopathological evaluation were performed on the 38th d and 48th d after surgery in both groups, respectively. RESULTS There were no significant differences between the experimental group and the control group in general characteristics such as body weight, gender, and the number of fistula (P > 0.05). In the experimental group, 15 fistulas were confirmed clinically, 13 complex fistulas were confirmed by MRI, and 11 complex fistulas were confirmed by histopathology. The success rate in the porcine complex fistula model establishment was 83.33%. Among the 18 fistulas in the control group, 5 fistulas were confirmed clinically, 4 complex fistulas were confirmed by MRI, and 3 fistulas were confirmed by histopathology. The success rate in the porcine fistula model establishment was 27.78%. Thus, the success rate of the rubber band ligation group was significantly higher than the control group (P < 0.05). CONCLUSION Rubber band ligation is a stable and reliable method to establish complex fistula-in-ano models. Large animal models of complex anal fistulas can be used for the diagnosis and treatment of anal fistulas. PMID:28348488

  11. Física e Arte nas Estações do Ano

    NASA Astrophysics Data System (ADS)

    Pessôa Queiroz, Glória; da Conceição Barbosa Lima, Maria; Navarro Vasconcellos das Mercês, Maria

    2004-12-01

    The paper deals with the subject of the Four Seasons, exploring elements of Science and the Art in order to motivate students or public of museums of science and technology to understand it from their current cultural experiences and of old times. Physics joins to Astronomy to explain the phenomenon, while the use of Music and Painting make possible the immersion in the subject in way to many trips to the imagination capable to awake emotions.A proposal didactic is presented and justified for some consensus of the research in the area of teaching-learning of science, since that related to the persistent alternative conceptions concerning the causes of the changes observed at the different times of the year until the qualitative modelling of phenomena that appeals three-dimensional pedagogical models. Such proposal was developed in the activity named " Hiper interesting Talk: The Four Seasons, Science and Art" in the first Sunday of August/2003 in the Museum of Astronomy, MAST. O artigo trata do tema das Estações do Ano, explorando elementos da Ciência e da Arte como forma de motivar estudantes ou público de museus de ciência e tecnologia a compreendê-lo a partir de vivências culturais atuais e de outras épocas. A Física se junta à Astronomia para explicar o fenômeno, enquanto a Música e a Pintura possibilitam a imersão no tema em meio a muitas viagens à imaginação capazes de despertar emoções.Uma proposta didática é apresentada e justificada por consensos das muitas pesquisas na área de ensino-aprendizagem de ciências, desde os que se referem às persistentes concepções alternativas acerca das causas das mudanças observadas nas diferentes épocas do ano até à modelagem qualitativa de fenômenos que recorre a modelos pedagógicos tridimensionais. Tal proposta foi desenvolvida na atividade "Bate papo Hiperinteressante: As Quatro Estações, Ciência e Arte" realizada no primeiro domingo do mês de agosto de 2003 no Museu de Astronomia.

  12. Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells

    PubMed Central

    Park, Jinhong; Jeon, Dong-kyu; Jo, Sungwoo; Lee, Ho K.

    2017-01-01

    Anoctamin 1 (ANO1), a calcium-activated chloride channel, is highly amplified in prostate cancer, the most common form of cancer and leading causes of cancer death in men, and downregulation of ANO1 expression or its functional activity is known to inhibit cell proliferation, migration and invasion in prostate cancer cells. Here, we performed a cell-based screening for the identification of ANO1 inhibitors as potential anticancer therapeutic agents for prostate cancer. Screening of ~300 selected bioactive natural products revealed that luteolin is a novel potent inhibitor of ANO1. Electrophysiological studies indicated that luteolin potently inhibited ANO1 chloride channel activity in a dose-dependent manner with an IC50 value of 9.8 μM and luteolin did not alter intracellular calcium signaling in PC-3 prostate cancer cells. Luteolin inhibited cell proliferation and migration of PC-3 cells expressing high levels of ANO1 more potently than that of ANO1-deficient PC-3 cells. Notably, luteolin not only inhibited ANO1 channel activity, but also strongly decreased protein expression levels of ANO1. Our results suggest that downregulation of ANO1 by luteolin is a potential mechanism for the anticancer effect of luteolin. PMID:28362855

  13. Ano-Genital Warts and HIV Status– A Clinical Study

    PubMed Central

    Sharma, Shimpa; Gulbake, Arvind

    2017-01-01

    Introduction Ano-Genital Warts (AGW) like other Sexually Transmitted Diseases (STD) is associated with Human Immunodeficiency Virus (HIV) infection. This study of AGW was done in HIV positive and HIV negative patients. Aim To study the risk factors and clinical presentations of ano-genital warts in HIV positive and negative patients. Materials and Methods A comparative, cross-sectional, descriptive study of 25 HIV positive and 25 HIV negative (n=50) AGW patients between 15-60 years of both sex was conducted in Dr. D. Y. Patil Hospital and Research Centre from July 2014 to July 2016. Results Significant association of HIV positivity (p<0.05) was observed between age group of 15-30 years and HIV negative status (p<0.05) in age group of 31-45 years. HIV positive status significantly higher in patients with self-admitted multiple sexual partners (p<0.01), homosexuality (p<0.05) and presentation with anal warts (p<0.01). HIV negative status correlated significantly with single sexual partner admission (p<0.01) and hetero-sexuality (p<0.05). Gender did not show significant association with number of sexual partners or HIV positivity. Extra-genital or only genital warts had no association with HIV status. Co-STDs though more in number in ser-positive group, did not show any significant association with HIV positivity (p>0.05). No patient presented with changes of malignancy. Four were adolescents below 19 years. Two patients had atypical presentations of giant condylomata i.e., Buschke-Lowenstein Tumour (BLT). Conclusion HIV positivity was significantly associated with the risk factors of age below 30 years, homo sexuality and multiple sexual partners. Anal warts were significantly common in HIV positive patients. Four adolescents with AGW underline the need for high risk behaviour counselling. No patient had malignant ano-genital warts. Follow up of these patients with Human Papilloma Virus (HPV) sub-typing is necessary. PMID:28274028

  14. A causa das estações do ano: modelos mentais

    NASA Astrophysics Data System (ADS)

    de Campos, J. A. S.; de Araujo, J. F. S.

    2003-08-01

    A década de 70 do século passado foi marcada pelo estudo das concepções alternativas que os alunos trazem para a sala de aula. A identificação destas concepções foi o ponto de partida para promover a mudança conceitual, onde as pré-concepções seriam trocadas pelas concepções científicas. Na década seguinte, surgiram muitas propostas de estratégias educacionais para facilitar esta troca, na sua maioria baseadas na idéia do conflito cognitivo, proposta por Piaget. Entretanto, os resultados pouco animadores conduziram à percepção de que a mudança conceitual é um processo mais complexo. Pelas idéias da Ciência Cognitiva, a mudança conceitual é uma mudança progressiva dos modelos mentais que o aluno tem sobre o mundo físico, através de enriquecimento e revisão. A causa das Estações do Ano é um tópico sobre o qual a maioria dos estudantes apresenta concepções alternativas. Os autores fizeram um levantamento sobre as pré-concepções encontradas em trabalhos sobre o tema (16 referências), procurando encontrar elementos comuns que indicassem a presença de modelos mentais específicos. As pré-concepções encontradas na literatura foram obtidas usando-se diversas metodologias (desde entrevistas clínicas até questionários de múltipla escolha) e envolvendo alunos e professores de diferentes regiões geográficas. A partir de uma análise aprofundada de cada trabalho, e utilizando-se a técnica das Redes Sistêmicas, chegou-se a conclusão que as diversas pré-concepções identificadas (em torno de 50), poderiam ser representadas por 6 modelos mentais, onde a explicação da causa das estações do ano tem um mecanismo causal responsável. Os mecanismos causais identificados foram: a dependência da distância, a dependência da orientação, a dependência conjunta da distância e orientação, a dependência da obstrução, a dependência da velocidade e a dependência da inclinação dos raios solares. Foram ainda identificadas

  15. Adenocarcinoma in an ano-vaginal fistula in Crohn's disease

    PubMed Central

    Alfa-Wali, Maryam; Atinga, Angela; Mohsen, Yasser; Anthony, Andrew; Myers, Alistair

    2013-01-01

    INTRODUCTION Fistulas are a relatively common occurrence in Crohn's disease (CD), and often present early in the disease process. Additionally, patients suffering from either CD or ulcerative colitis are shown to have an increased risk of colorectal malignancies compared with the general population. PRESENTATION OF CASE We present a case of adenocarcinoma in an ano-vaginal fistula in a patient with longstanding CD. DISCUSSION Various pathogenic mechanisms for the development of carcinoma in fistulas have been suggested, but there is no consensus and indeed this risk may be cumulative. In this case report, we also discuss the pathogenesis of mucinous adenocarcinoma in fistulas secondary to CD. CONCLUSION Better detection of adenocarcinoma in patients presenting with persistent non-resolving fistulas in the presence of CD should be undertaken with regular biopsies following examinations under anaesthetic of the anorectum. PMID:23702362

  16. An Allegory of Addiction Recovery: Exploring the Performance of "Eumenides" by Aeschylus, as Adapted by 18 ANO Theatre Group

    ERIC Educational Resources Information Center

    Zontou, Zoe

    2013-01-01

    This paper examines the performance of the "Eumenides," as adapted and performed by 18 ANO theatre group. 18 ANO is the theatre group of the Drug dependence treatment unit 18 ANO of Attica's Psychiatric Hospital, which is based in Athens, Greece. Each year 18 ANO organises performances in the wider community with the aim of promoting…

  17. An Allegory of Addiction Recovery: Exploring the Performance of "Eumenides" by Aeschylus, as Adapted by 18 ANO Theatre Group

    ERIC Educational Resources Information Center

    Zontou, Zoe

    2013-01-01

    This paper examines the performance of the "Eumenides," as adapted and performed by 18 ANO theatre group. 18 ANO is the theatre group of the Drug dependence treatment unit 18 ANO of Attica's Psychiatric Hospital, which is based in Athens, Greece. Each year 18 ANO organises performances in the wider community with the aim of promoting…

  18. Identification of a lipid scrambling domain in ANO6/TMEM16F

    PubMed Central

    Yu, Kuai; Whitlock, Jarred M; Lee, Kyleen; Ortlund, Eric A; Yuan Cui, Yuan; Hartzell, H Criss

    2015-01-01

    Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated bidirectional transport of phospholipids down their concentration gradient between membrane leaflets. ANO6/TMEM16F has been shown to be essential for Ca2+-dependent PLS, but controversy surrounds whether ANO6 is a phospholipid scramblase or an ion channel like other ANO/TMEM16 family members. Combining patch clamp recording with measurement of PLS, we show that ANO6 elicits robust Ca2+-dependent PLS coinciding with ionic currents that are explained by ionic leak during phospholipid translocation. By analyzing ANO1-ANO6 chimeric proteins, we identify a domain in ANO6 necessary for PLS and sufficient to confer this function on ANO1, which normally does not scramble. Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets. These findings provide a mechanistic framework for understanding PLS and how ANO6 functions in this process. DOI: http://dx.doi.org/10.7554/eLife.06901.001 PMID:26057829

  19. ANOs 3–7 in the anoctamin/Tmem16 Cl− channel family are intracellular proteins

    PubMed Central

    Duran, Charity; Qu, Zhiqiang; Osunkoya, Adeboye O.; Cui, Yuanyuan

    2012-01-01

    Ca2+-activated Cl− channels (CaCCs) participate in numerous physiological functions such as neuronal excitability, sensory transduction, and transepithelial fluid transport. Recently, it was shown that heterologously expressed anoctamins ANO1 and ANO2 generate currents that resemble native CaCCs. The anoctamin family (also called Tmem16) consists of 10 members, but it is not known whether all members of the family are CaCCs. Expression of ANOs 3–7 in HEK293 cells did not generate Cl− currents activated by intracellular Ca2+, as determined by whole cell patch clamp electrophysiology. With the use of confocal imaging, only ANO1 and ANO2 traffic to the plasma membrane when expressed heterologously. Furthermore, endogenously expressed ANO7 in the human prostate is predominantly intracellular. We took a chimeric approach to identify regions critical for channel trafficking and function. However, none of the chimeras of ANO1 and ANO5/7 that we made trafficked to the plasma membrane. Our results suggest that intracellular anoctamins may be endoplasmic reticulum proteins, although it remains unknown whether these family members are CaCCs. Determining the role of anoctamin family members in ion transport will be critical to understanding their functions in physiology and disease. PMID:22075693

  20. ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human scc-25 cells

    PubMed Central

    Li, Yadong; Zhang, Jinsong

    2014-01-01

    Objectives: The purpose of this study is to confirm that ANO1 correlates with occurrence and metastasis of OSCC. Study Design: Immunohistochemistry was used to detect the expression of ANO1 in 160 specimens of OSCC and normal tissues. Lentiviral silencing ANO1 was used in scc-25 cell line to study the cell migration and cell detachment. Results: Immunohistochemical staining revealed that ANO1 was expressed in a large majority (132 out of 160, 82.5%) of OSCC specimens and that the rate of ANO1 expression in OSCC was significantly higher than that of normal tissue (P<0.05); The rate of ANO1 expression was higher in metastatic tumors than in non-metastatic tumors, and the difference was significant (P<0.05). The results of cell migration assay showed that the percentage of cells through the membrane was 26.61 ±0.81 in assay group, and 54.26 ±3.74 in control group, respectively (t=-16.22,P<0.0001). The results of cell detachment assay showed that the percentage of cells detachment was 37.42 ±0.90 in assay group, and 87.38 ±1.59 in control group, respectively (t=-62.34, P<0.0001). The results of wound healing assay showed the assay group had a reduced migration rate compared with the control group in 32 h (F=1038.78, P<0.0001). Wound closure was no significantly different between the assay and control cells when DIDS was used in wound healing assay (F=4.61,P>0.05). Conclusions: Our study shows that abnormal expression of ANO1 correlated with the occurrence and metastasis of OSCC in clinical specimens and that silencing ANO1 greatly reduced migration ability of scc-25 cells. Calcium activated chloride channel activity of ANO1 promoted the cell migration. Thus, ANO1 could represent a new diagnostic biomarker and a potentially important therapeutic target of OSCC. Key words:Oral squamous cell carcinoma, chloride channel, metastasis. PMID:24316695

  1. A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.

    PubMed

    Strege, Peter R; Bernard, Cheryl E; Mazzone, Amelia; Linden, David R; Beyder, Arthur; Gibbons, Simon J; Farrugia, Gianrico

    2015-11-01

    Anoctamin 1 (Ano1; TMEM16A) is a Ca(2+)-activated Cl(-) channel (CACC) expressed in interstitial cells of Cajal. The mechanisms by which Ca(2+) regulates Ano1 are incompletely understood. In the gastrointestinal tract, Ano1 is required for normal slow wave activity and is involved in regulating cell proliferation. Splice variants of Ano1 have varying electrophysiological properties and altered expression in disease states. Recently, we identified a transcript for human Ano1 containing a novel exon-"exon 0" upstream of and in frame with exon 1. The electrophysiological properties of this longer Ano1 isoform are unknown. Our aim was to determine the functional contribution of the newly identified exon to the Ca(2+) sensitivity and electrophysiological properties of Ano1. Constructs with [Ano1(+0)] or without [Ano1(-0)] the newly identified exon were transfected into human embryonic kidney-293 cells. Voltage-clamp electrophysiology was used to determine voltage- and time-dependent parameters of whole cell Cl(-) currents between isoforms with varying concentrations of intracellular Ca(2+), extracellular anions, or Cl(-) channel inhibitors. We found that exon 0 did not change voltage sensitivity and had no impact on the relative permeability of Ano1 to most anions. Ano1(+0) exhibited greater changes in current density but lesser changes in kinetics than Ano1(-0) in response to varying intracellular Ca(2+). The CACC inhibitor niflumic acid inhibited current with greater efficacy and higher potency against Ano1(+0) compared with Ano1(-0). Likewise, the Ano1 inhibitor T16Ainh-A01 reduced Ano1(+0) more than Ano1(-0). In conclusion, human Ano1 containing exon 0 imparts its Cl(-) current with greater sensitivity to intracellular Ca(2+) and CACC inhibitors.

  2. A novel exon in the human Ca2+-activated Cl− channel Ano1 imparts greater sensitivity to intracellular Ca2+

    PubMed Central

    Strege, Peter R.; Bernard, Cheryl E.; Mazzone, Amelia; Linden, David R.; Beyder, Arthur; Gibbons, Simon J.

    2015-01-01

    Anoctamin 1 (Ano1; TMEM16A) is a Ca2+-activated Cl− channel (CACC) expressed in interstitial cells of Cajal. The mechanisms by which Ca2+ regulates Ano1 are incompletely understood. In the gastrointestinal tract, Ano1 is required for normal slow wave activity and is involved in regulating cell proliferation. Splice variants of Ano1 have varying electrophysiological properties and altered expression in disease states. Recently, we identified a transcript for human Ano1 containing a novel exon-“exon 0” upstream of and in frame with exon 1. The electrophysiological properties of this longer Ano1 isoform are unknown. Our aim was to determine the functional contribution of the newly identified exon to the Ca2+ sensitivity and electrophysiological properties of Ano1. Constructs with [Ano1(+0)] or without [Ano1(−0)] the newly identified exon were transfected into human embryonic kidney-293 cells. Voltage-clamp electrophysiology was used to determine voltage- and time-dependent parameters of whole cell Cl− currents between isoforms with varying concentrations of intracellular Ca2+, extracellular anions, or Cl− channel inhibitors. We found that exon 0 did not change voltage sensitivity and had no impact on the relative permeability of Ano1 to most anions. Ano1(+0) exhibited greater changes in current density but lesser changes in kinetics than Ano1(−0) in response to varying intracellular Ca2+. The CACC inhibitor niflumic acid inhibited current with greater efficacy and higher potency against Ano1(+0) compared with Ano1(−0). Likewise, the Ano1 inhibitor T16Ainh-A01 reduced Ano1(+0) more than Ano1(−0). In conclusion, human Ano1 containing exon 0 imparts its Cl− current with greater sensitivity to intracellular Ca2+ and CACC inhibitors. PMID:26359375

  3. Activation of Ca(2+) -activated Cl(-) channel ANO1 by localized Ca(2+) signals.

    PubMed

    Jin, Xin; Shah, Sihab; Du, Xiaona; Zhang, Hailin; Gamper, Nikita

    2016-01-01

    Ca(2+)-activated chloride channels (CaCCs) regulate numerous physiological processes including epithelial transport, smooth muscle contraction and sensory processing. Anoctamin-1 (ANO1, TMEM16A) is a principal CaCC subunit in many cell types, yet our understanding of the mechanisms of ANO1 activation and regulation are only beginning to emerge. Ca(2+) sensitivity of ANO1 is rather low and at negative membrane potentials the channel requires several micromoles of intracellular Ca(2+) for activation. However, global Ca(2+) levels in cells rarely reach such levels and, therefore, there must be mechanisms that focus intracellular Ca(2+) transients towards the ANO1 channels. Recent findings indeed indicate that ANO1 channels often co-localize with sources of intracellular Ca(2+) signals. Interestingly, it appears that in many cell types ANO1 is particularly tightly coupled to the Ca(2+) release sites of the intracellular Ca(2+) stores. Such preferential coupling may represent a general mechanism of ANO1 activation in native tissues.

  4. EAVK "segment c" sequence confers Ca(2+)-dependent changes to the kinetics of full length human Ano1.

    PubMed

    Strege, Peter R; Gibbons, Simon J; Mazzone, Amelia; Bernard, Cheryl E; Beyder, Arthur; Farrugia, Gianrico

    2017-03-23

    Anoctamin1 (Ano1, TMEM16A) is a calcium-activated chloride channel specifically expressed in interstitial cells of Cajal (ICC) of the gastrointestinal (GI) tract muscularis propria. Ano1 is necessary for normal electrical slow waves and ICC proliferation. The full length human Ano1 sequence includes an additional exon, exon "0," at the N-terminus. Ano1 with exon "0" (Ano1(0)) had a lower EC50 for intracellular calcium ([Ca(2+)]i) and faster chloride current (ICl) kinetics. The Ano1 alternative splice variant with segment "c" encoding exon 13 expresses on the first intracellular loop four additional amino acid residues, EAVK, which alter ICl at low [Ca(2+)]i Exon 13 is expressed in 75-100% of Ano1 transcripts in most human tissues but only 25% in human stomach. Our aim was to determine the effect of EAVK deletion on Ano1(0) ICl parameters. By voltage-clamp electrophysiology, we examined ICl in HEK293 cells transiently expressing Ano1(0) with or without the EAVK sequence (Ano1(0)ΔEAVK). The EC50 values of activating and deactivating ICl for [Ca(2+)]i was 438±7 and 493±9 nM for Ano1(0) but higher for Ano1(0)ΔEAVK at 746±47 and 761±26 nM, respectively. Meanwhile, the EC50 values for the ratio of instantaneous to steady-state ICl were not different between variants. Congruently, the time constant of activation was slower for Ano1(0)ΔEAVK than Ano1(0) currents at intermediate [Ca(2+)]i These results suggest that EAVK decreases the calcium sensitivity of Ano1(0) current activation and deactivation by slowing activation kinetics. Differential expression of EAVK in human stomach may function as a switch to increase sensitivity to [Ca(2+)]i via faster gating of Ano1.

  5. Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells.

    PubMed

    Guan, Lizhao; Song, Yan; Gao, Jian; Gao, Jianjun; Wang, KeWei

    2016-11-29

    ANO1, a calcium-activated chloride channel, has been reported to be amplified or overexpressed in tissues of several cancers. However, reports on its roles in tumor progression obtained from cancer cell lines are inconsistent, suggesting that the role of ANO1 in tumorigenesis is likely dependent on either its expression level or cell-type expressing ANO1. To investigate the biological roles of ANO1 in different tumor cells, we, in this study, selected several cancer cell lines and a normal HaCaT cell line with high expression levels of ANO1, and examined the function of ANO1 in these cells using approaches of lentiviral knockdown and pharmacological inhibition. We found that ANO1 knockdown significantly inhibited cell proliferation and induced cell apoptosis in either tumor cell lines or normal HaCaT cell line. Moreover, silencing ANO1 arrested cancer cells at G1 phase of cell cycle. Treatment with ANO1 inhibitor CaCCinh-A01 reduced cell viability in a dose-dependent manner. Furthermore, both ANO1 inhibitors CaCCinh-A01 and T16Ainh-A01 significantly suppressed cell migration. Our findings show that ANO1 overexpression promotes cancer cell proliferation and migration; and genetic or pharmacological inhibition of ANO1 induces apoptosis and cell cycle arrest at G1 phase in different types of epithelium-originated cancer cells.

  6. Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells

    PubMed Central

    Guan, Lizhao; Song, Yan; Gao, Jian; Gao, Jianjun; Wang, KeWei

    2016-01-01

    ANO1, a calcium-activated chloride channel, has been reported to be amplified or overexpressed in tissues of several cancers. However, reports on its roles in tumor progression obtained from cancer cell lines are inconsistent, suggesting that the role of ANO1 in tumorigenesis is likely dependent on either its expression level or cell-type expressing ANO1. To investigate the biological roles of ANO1 in different tumor cells, we, in this study, selected several cancer cell lines and a normal HaCaT cell line with high expression levels of ANO1, and examined the function of ANO1 in these cells using approaches of lentiviral knockdown and pharmacological inhibition. We found that ANO1 knockdown significantly inhibited cell proliferation and induced cell apoptosis in either tumor cell lines or normal HaCaT cell line. Moreover, silencing ANO1 arrested cancer cells at G1 phase of cell cycle. Treatment with ANO1 inhibitor CaCCinh-A01 reduced cell viability in a dose-dependent manner. Furthermore, both ANO1 inhibitors CaCCinh-A01 and T16Ainh-A01 significantly suppressed cell migration. Our findings show that ANO1 overexpression promotes cancer cell proliferation and migration; and genetic or pharmacological inhibition of ANO1 induces apoptosis and cell cycle arrest at G1 phase in different types of epithelium-originated cancer cells. PMID:27732935

  7. DEZ ANOS DE EXPERIÊNCIA DO COMITÊ DE ÉTICA EM PESQUISA DA SECRETARIA DE SAÚDE DO DISTRITO FEDERAL, BRASIL

    PubMed Central

    Novaes, Maria Rita C. G.; Guilhem, Dirce; Lolas, Fernando

    2009-01-01

    O objetivo deste artigo é relatar a experiência do Comitê de Ética em Pesquisa da Secretaria de Estado de Saúde do Distrito Federal (CEP/SES/DF) Brasil, durante o período de 10 anos a partir de sua fundação. Trata-se de uma avaliação descritiva e documental, na modalidade estudo de caso, utilizando-se a totalidade de projetos protocolados no CEP/SES/DF (N° 052/08) nesse período. As pendências mais freqüentes dos projetos foram: termo de consentimento livre e esclarecido (30%), folha de rosto (25%), metodologia (20%), curriculum vitae (12%), planilha de orçamento (9%), outros (4%). O relato das atividades do CEP/SES/DF no período de 10 anos revelou, através de sua produtividade, a legitimidade do processo de análise ética dos protocolos visando à proteção dos participantes da pesquisa. PMID:19888441

  8. Interstellar Material towards eta UMa

    NASA Astrophysics Data System (ADS)

    Frisch, P. C.; Jenkins, E. B.; Welty, D. E.; Johns-Krull, C.

    1999-05-01

    The star eta UMa (B3 V, vsini=205 km s(-1) , d=31 pc, l=101(o) , b=+65(o) ) samples nearby interstellar gas in a high latitude direction relatively devoid of material. IMAPS, Hubble GHRS Echelle, and ground based optical data are combined to present a comprehensive picture of the interstellar material (ISM) in this direction. Two main components dominate: the blue-shifted component which appears to be ionized, and the dominant, red-shifted, component which exhibits a low electron density ( ~ 0.2 cm(-3) ). However, the Mg(o/Mg^+) ratio and C(+) fine-structure lines yield different ionizations, depending on the adopted temperature, similar to differences found in the diffuse material towards 23 Ori (Welty et al. 1999). The IMAPS and GHRS data give C, N, O, and Fe column densities, which form the basis for calculating the gas-to-dust mass ratio for the main component using a ``missing mass'' calculation combined with an assumed reference abundance (Frisch et al. 1999). Comparing the eta UMa value with other diffuse cloud values then further constrains uncertainties in N(H(o) ) values for this sightline.

  9. MR imaging of fistula in ano: indications and contribution to surgical assessment.

    PubMed

    Mullen, R; Deveraj, S; Suttie, S A; Matthews, A G; Yalamarthi, S

    2011-01-01

    Magnetic Resonance Imaging (MRI) is the imaging modality of choice for fistula in ano. The purpose of this study was to analyse the use of MRI, and to assess its contribution towards the assessment of this sometimes difficult condition. A retrospective analysis of all patients with fistula in ano between January 2003 and December 2007 was performed, focussing on those who had MRI assessment. The primary pathology, indication for MRI and the contribution of this investigation to assessment of fistula in ano were analysed. MRI was performed in 40 patients. The primary pathologies included: perianal sepsis in 20 (50%), Crohn's disease in 11 (27.5%), primary fistula in ano in 6 (15%) and others in 3 (7.5%) patients. Indications for MRI were to assess the fistula anatomy in 17 (42.5%), to assess a clinically suspected fistula in 12 (30%), to assess a complex fistula found at Examination Under Anaesthesia (EUA) in 6 (15%) and to exclude a fistula in 5 (12.5%). MRI was considered helpful in 34 (85%) of all cases. MRI established the fistula anatomy and guided further surgery in 47.1%, correlated with EUA findings in 38.2% and excluded a suspected fistula in 14.7% of these. This study further supports the benefit of using MRI to assess fistula in ano. When used in selected patients, it was of benefit in 85% of cases, by establishing fistula anatomy and guiding further surgery, correlating EUA findings or excluding a clinically suspected fistula.

  10. [Epidemiology and management of patients with ano-genital warts in Italy].

    PubMed

    Suligoi, Barbara; Salfa, Maria Cristina; Mariani, Luciano

    2010-01-01

    Overview of the impact of ano-genital warts in Italy. In Italy, the HPV infection is not subject to mandatory reporting, the available epidemiological data come from sentinel surveillance of STIs and show a high spread among young people under 25 years and an increase in reports after 2004. Although ano-genital warts are a benign disease, nonetheless they are characterized by a big relational and psycho-sexual impact, due also to high recurrence rates. It is extremely useful to promote information activities, education in safe sex, early diagnosis and treatment of genital warts. In this context, primary prevention through vaccination represents a valid tool of protection.

  11. Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

    PubMed Central

    Zhu, Jinqiu; Qu, Zhiqiang; Cui, Yuan-Yuan; Hartzell, H. Criss

    2014-01-01

    The Ca2+-activated Cl channel anoctamin-1 (Ano1; Tmem16A) plays a variety of physiological roles, including epithelial fluid secretion. Ano1 is activated by increases in intracellular Ca2+, but there is uncertainty whether Ca2+ binds directly to Ano1 or whether phosphorylation or additional Ca2+-binding subunits like calmodulin (CaM) are required. Here we show that CaM is not necessary for activation of Ano1 by Ca2+ for the following reasons. (a) Exogenous CaM has no effect on Ano1 currents in inside-out excised patches. (b) Overexpression of Ca2+-insensitive mutants of CaM have no effect on Ano1 currents, whereas they eliminate the current mediated by the small-conductance Ca2+-activated K+ (SK2) channel. (c) Ano1 does not coimmunoprecipitate with CaM, whereas SK2 does. Furthermore, Ano1 binds very weakly to CaM in pull-down assays. (d) Ano1 is activated in excised patches by low concentrations of Ba2+, which does not activate CaM. In addition, we conclude that reversible phosphorylation/dephosphorylation is not required for current activation by Ca2+ because the current can be repeatedly activated in excised patches in the absence of ATP or other high-energy compounds. Although Ano1 is blocked by the CaM inhibitor trifluoperazine (TFP), we propose that TFP inhibits the channel in a CaM-independent manner because TFP does not inhibit Ano1 when applied to the cytoplasmic side of excised patches. These experiments lead us to conclude that CaM is not required for activation of Ano1 by Ca2+. Although CaM is not required for channel opening by Ca2+, work of other investigators suggests that CaM may have effects in modulating the biophysical properties of the channel. PMID:24420770

  12. Next generation sequencing on patients with LGMD and nonspecific myopathies: Findings associated with ANO5 mutations

    PubMed Central

    Savarese, Marco; Di Fruscio, Giuseppina; Tasca, Giorgio; Ruggiero, Lucia; Janssens, Sandra; De Bleecker, Jan; Delpech, Marc; Musumeci, Olimpia; Toscano, Antonio; Angelini, Corrado; Sacconi, Sabrina; Santoro, Lucio; Ricci, Enzo; Claes, Kathleen; Politano, Luisa; Nigro, Vincenzo

    2015-01-01

    We studied 786 undiagnosed patients with LGMD or nonspecific myopathic features to investigate the role of ANO5 mutations in limb-girdle muscular dystrophies (LGMDs) and in nonspecific myopathies using the next generation sequencing (NGS) approach. In 160 LGMD patients, we first sequenced hotspot exons 5 and 20 and then sequenced the remaining part of the coding region. Another 626 patients, recruited using broader inclusion criteria, were directly analyzed by targeted NGS. By combining NGS and Sanger sequencing, we identified 33/786 (4%) patients carrying putative pathogenic changes in both alleles and 23 ANO5 heterozygotes (3%). The phenotypic spectrum is broader than expected, from hyperCKemia to myopathies, with lack of genotype/phenotype correlations. In particular, this is currently the largest screening of the ANO5 gene. The large number of heterozygotes for damaging mutations suggests that anoctaminopathies should be frequent and often nonpenetrant. We propose the multiple genetic testing by targeted NGS as a first step to analyze patients with nonspecific myopathic presentations. This represents a straightforward approach to overcome the difficulties of clinical heterogeneity of ANO5 patients, and to test, at the same time, many other genes involved in neuromuscular disorders. PMID:25891276

  13. A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity.

    PubMed

    Hammer, Christian; Wanitchakool, Podchanart; Sirianant, Lalida; Papiol, Sergi; Monnheimer, Mathieu; Faria, Diana; Ousingsawat, Jiraporn; Schramek, Natalie; Schmitt, Corinna; Margos, Gabriele; Michel, Angelika; Kraiczy, Peter; Pawlita, Michael; Schreiber, Rainer; Schulz, Thomas F; Fingerle, Volker; Tumani, Hayrettin; Ehrenreich, Hannelore; Kunzelmann, Karl

    2015-02-23

    In a first genome-wide association study (GWAS) approach to anti-Borrelia seropositivity, we identified two significant single nucleotide polymorphisms (SNPs) (rs17850869, P = 4.17E-09; rs41289586, P = 7.18E-08). Both markers, located on chromosomes 16 and 3, respectively, are within or close to genes previously connected to spinocerebellar ataxia. The risk SNP rs41289586 represents a missense variant (R263H) of anoctamin 10 (ANO10), a member of a protein family encoding Cl(-) channels and phospholipid scramblases. ANO10 augments volume-regulated Cl(-) currents (IHypo) in Xenopus oocytes, HEK293 cells, lymphocytes and macrophages and controls volume regulation by enhancing regulatory volume decrease (RVD). ANO10 supports migration of macrophages and phagocytosis of spirochetes. The R263H variant is inhibitory on IHypo, RVD and intracellular Ca(2+) signals, which may delay spirochete clearance, thereby sensitizing adaptive immunity. Our data demonstrate for the first time that ANO10 has a central role in innate immune defense against Borrelia infection.

  14. Next generation sequencing on patients with LGMD and nonspecific myopathies: Findings associated with ANO5 mutations.

    PubMed

    Savarese, Marco; Di Fruscio, Giuseppina; Tasca, Giorgio; Ruggiero, Lucia; Janssens, Sandra; De Bleecker, Jan; Delpech, Marc; Musumeci, Olimpia; Toscano, Antonio; Angelini, Corrado; Sacconi, Sabrina; Santoro, Lucio; Ricci, Enzo; Claes, Kathleen; Politano, Luisa; Nigro, Vincenzo

    2015-07-01

    We studied 786 undiagnosed patients with LGMD or nonspecific myopathic features to investigate the role of ANO5 mutations in limb-girdle muscular dystrophies (LGMDs) and in nonspecific myopathies using the next generation sequencing (NGS) approach. In 160 LGMD patients, we first sequenced hotspot exons 5 and 20 and then sequenced the remaining part of the coding region. Another 626 patients, recruited using broader inclusion criteria, were directly analyzed by targeted NGS. By combining NGS and Sanger sequencing, we identified 33/786 (4%) patients carrying putative pathogenic changes in both alleles and 23 ANO5 heterozygotes (3%). The phenotypic spectrum is broader than expected, from hyperCKemia to myopathies, with lack of genotype/phenotype correlations. In particular, this is currently the largest screening of the ANO5 gene. The large number of heterozygotes for damaging mutations suggests that anoctaminopathies should be frequent and often nonpenetrant. We propose the multiple genetic testing by targeted NGS as a first step to analyze patients with nonspecific myopathic presentations. This represents a straightforward approach to overcome the difficulties of clinical heterogeneity of ANO5 patients, and to test, at the same time, many other genes involved in neuromuscular disorders. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  15. The Phenotypic Spectrum of DYT24 Due to ANO3 Mutations

    PubMed Central

    Stamelou, Maria; Charlesworth, Gavin; Cordivari, Carla; Schneider, Susanne A; Kägi, Georg; Sheerin, Una-Marie; Rubio-Agusti, Ignacio; Batla, Amit; Houlden, Henry; Wood, Nicholas W; Bhatia, Kailash P

    2014-01-01

    Genes causing primary dystonia are rare. Recently, pathogenic mutations in the anoctamin 3 gene (ANO3) have been identified to cause autosomal dominant craniocervical dystonia and have been assigned to the dystonia locus dystonia-24 (DYT24). Here, we expand on the phenotypic spectrum of DYT24 and provide demonstrative videos. Moreover, tremor recordings were performed, and back-averaged electroencephalography, sensory evoked potentials, and C-reflex studies were carried out in two individuals who carried two different mutations in ANO3. Ten patients from three families are described. The age at onset ranged from early childhood to the forties. Cervical dystonia was the most common site of onset followed by laryngeal dystonia. The characteristic feature in all affected individuals was the presence of tremor, which contrasts DYT24 from the typical DYT6 phenotype. Tremor was the sole initial manifestation in some individuals with ANO3 mutations, leading to misdiagnosis as essential tremor. Electrophysiology in two patients with two different mutations showed co-contraction of antagonist muscles, confirming dystonia, and a 6-Hz arm tremor at rest, which increased in amplitude during action. In one of the studied patients, clinically superimposed myoclonus was observed. The duration of the myoclonus was in the range of 250 msec at about 3 Hz, which is more consistent with subcortical myoclonus. In summary, ANO3 causes a varied phenotype of young-onset or adult-onset craniocervical dystonia with tremor and/or myoclonic jerks. Patients with familial cervical dystonia who also have myoclonus-dystonia as well as patients with prominent tremor and mild dystonia should be tested for ANO3 mutations. © 2014 The Authors. Movement Disorders published by International Parkinson and Movement Disorder Society PMID:24442708

  16. ANO10 mutations cause ataxia and coenzyme Q₁₀ deficiency.

    PubMed

    Balreira, Andrea; Boczonadi, Veronika; Barca, Emanuele; Pyle, Angela; Bansagi, Boglarka; Appleton, Marie; Graham, Claire; Hargreaves, Iain P; Rasic, Vedrana Milic; Lochmüller, Hanns; Griffin, Helen; Taylor, Robert W; Naini, Ali; Chinnery, Patrick F; Hirano, Michio; Quinzii, Catarina M; Horvath, Rita

    2014-11-01

    Inherited ataxias are heterogeneous disorders affecting both children and adults, with over 40 different causative genes, making molecular genetic diagnosis challenging. Although recent advances in next-generation sequencing have significantly improved mutation detection, few treatments exist for patients with inherited ataxia. In two patients with adult-onset cerebellar ataxia and coenzyme Q10 (CoQ10) deficiency in muscle, whole exome sequencing revealed mutations in ANO10, which encodes anoctamin 10, a member of a family of putative calcium-activated chloride channels, and the causative gene for autosomal recessive spinocerebellar ataxia-10 (SCAR10). Both patients presented with slowly progressive ataxia and dysarthria leading to severe disability in the sixth decade. Epilepsy and learning difficulties were also present in one patient, while retinal degeneration and cataract were present in the other. The detection of mutations in ANO10 in our patients indicate that ANO10 defects cause secondary low CoQ10 and SCAR10 patients may benefit from CoQ10 supplementation.

  17. A systematic review of new treatments for cryptoglandular fistula in ano.

    PubMed

    Narang, Sunil K; Keogh, Kenneth; Alam, Nasra N; Pathak, Samir; Daniels, Ian R; Smart, Neil J

    2017-02-01

    In 2007 the ACPGBI published a position statement on the management of cryptoglandular fistula in ano. Over the last seven years a number of new treatments have been developed and the aim of this systematic review was to assess their effectiveness. A systematic review of all English language literature relevant to novel treatment strategies for cryptoglandular fistula in ano, published between 1 January 2007 and 31 Dec 2014 was carried out using MEDLINE (PubMed and Ovid), EMBASE (Ovid) and the Cochrane Library of Systematic Reviews/Controlled Trials for relevant literature. Technical notes, commentaries, letters and meeting abstracts were excluded. The different treatments were assessed with regards to fistula closure rate in relation to length of follow up and reported complications. Seventy potential articles published between 1 January 2007 and 31 December 2014 were identified from the initial literature search. Twenty-one articles were included for final analysis although only two were randomized controlled trials, the remainder being retrospective or prospective series. This systematic review has demonstrated that whilst there have been technological advances to treat complex cryptoglandular fistula in ano, these are in an early stage of evolution and although early results were promising they are difficult to reproduce. Longer follow up data is not currently available and these treatments should not be introduced without further evidence. Copyright © 2016 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

  18. Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.

    PubMed

    Bill, Anke; Popa, M Oana; van Diepen, Michiel T; Gutierrez, Abraham; Lilley, Sarah; Velkova, Maria; Acheson, Kathryn; Choudhury, Hedaythul; Renaud, Nicole A; Auld, Douglas S; Gosling, Martin; Groot-Kormelink, Paul J; Gaither, L Alex

    2015-01-09

    The calcium-activated chloride channel ANO1 regulates multiple physiological processes. However, little is known about the mechanism of channel gating and regulation of ANO1 activity. Using a high-throughput, random mutagenesis-based variomics screen, we generated and functionally characterized ∼6000 ANO1 mutants and identified novel mutations that affected channel activity, intracellular trafficking, or localization of ANO1. Mutations such as S741T increased ANO1 calcium sensitivity and rendered ANO1 calcium gating voltage-independent, demonstrating a critical role of the re-entrant loop in coupling calcium and voltage sensitivity of ANO1 and hence in regulating ANO1 activation. Our data present the first unbiased and comprehensive study of the structure-function relationship of ANO1. The novel ANO1 mutants reported have diverse functional characteristics, providing new tools to study ANO1 function in biological systems, paving the path for a better understanding of the function of ANO1 and its role in health and diseases.

  19. Variomics Screen Identifies the Re-entrant Loop of the Calcium-activated Chloride Channel ANO1 That Facilitates Channel Activation*

    PubMed Central

    Bill, Anke; Popa, M. Oana; van Diepen, Michiel T.; Gutierrez, Abraham; Lilley, Sarah; Velkova, Maria; Acheson, Kathryn; Choudhury, Hedaythul; Renaud, Nicole A.; Auld, Douglas S.; Gosling, Martin; Groot-Kormelink, Paul J.; Gaither, L. Alex

    2015-01-01

    The calcium-activated chloride channel ANO1 regulates multiple physiological processes. However, little is known about the mechanism of channel gating and regulation of ANO1 activity. Using a high-throughput, random mutagenesis-based variomics screen, we generated and functionally characterized ∼6000 ANO1 mutants and identified novel mutations that affected channel activity, intracellular trafficking, or localization of ANO1. Mutations such as S741T increased ANO1 calcium sensitivity and rendered ANO1 calcium gating voltage-independent, demonstrating a critical role of the re-entrant loop in coupling calcium and voltage sensitivity of ANO1 and hence in regulating ANO1 activation. Our data present the first unbiased and comprehensive study of the structure-function relationship of ANO1. The novel ANO1 mutants reported have diverse functional characteristics, providing new tools to study ANO1 function in biological systems, paving the path for a better understanding of the function of ANO1 and its role in health and diseases. PMID:25425649

  20. Orbital period variations of two W UMa-type binaries: UY UMa and EF Boo

    NASA Astrophysics Data System (ADS)

    Yu, Yun-Xia; Zhang, Xu-Dong; Hu, Ke; Xiang, Fu-Yuan

    2017-08-01

    The orbital period variations of two W UMa-type contact binaries, UY UMa and EF Boo, are analyzed by using all available times of light minimum. It is detected that the general trends of their (O - C) curves show an upward parabolic variation, which reveals their continuous period increases at the rates of dP / dt = 2.545 ×10-7 days yr-1 and dP / dt = 2.623 ×10-7 days yr-1 , respectively. Meanwhile, UY UMa also shows a cyclic period variation with a small amplitude of A = 0.0026 days superposed on the long-term increase. Due to their contact configurations, the secular period increases are interpreted as a result of mass transfer from the less massive component to the more massive one. The cyclic period variation of UY UMa may be interpreted in terms of either the magnetic activity or the light time effect.

  1. Inhibition of Cell Proliferation by a Selective Inhibitor of the Ca2+-activated Cl− Channel, Ano1

    PubMed Central

    Mazzone, Amelia; Eisenman, Seth T.; Strege, Peter R.; Yao, Zhen; Ordog, Tamas; Gibbons, Simon J.; Farrugia, Gianrico

    2012-01-01

    Background Ion channels play important roles in regulation of cellular proliferation. Ano1 (TMEM16A) is a Ca2+-activated Cl− channel expressed in several tumors and cell types. In the muscle layers of the gastrointestinal tract Ano1 is selectively expressed in interstitial cells of Cajal (ICC) and appears to be required for normal gastrointestinal slow wave electrical activity. However, Ano1 is expressed in all classes of ICC, including those that do not generate slow waves suggesting that Ano1 may have other functions. Indeed, a role for Ano1 in regulating proliferation of tumors and ICC has been recently suggested. Recently, a high-throughput screen identified a small molecule, T16Ainh-A01 as a specific inhibitor of Ano1. Aim To investigate the effect of the T16Ainh-A01 inhibitor on proliferation in ICC and in the Ano1-expressing human pancreatic cancer cell line CFPAC-1. Methods Inhibition of Ano1 was demonstrated by whole cell voltage clamp recordings of currents in cells transfected with full-length human Ano1. The effect of T16Ainh-A01 on ICC proliferation was examined in situ in organotypic cultures of intact mouse small intestinal smooth muscle strips and in primary cell cultures prepared from these tissues. ICC were identified by Kit immunoreactivity. Proliferating ICC and CFPAC-1 cells were identified by immunoreactivity for the nuclear antigen Ki67 or EdU incorporation, respectively. Results T16Ainh-A01 inhibited Ca2+- activated Cl− currents by 60% at 10 µM in a voltage-independent fashion. Proliferation of ICC was significantly reduced in primary cultures from BALB/c mice following treatment with T16Ainh-A01. Proliferation of the CFPAC-1 human cell-line was also reduced by T16Ainh-A01. In organotypic cultures of smooth muscle strips from mouse jejunum, the proliferation of ICC was reduced but the total number of proliferating cells/confocal stack was not affected, suggesting that the inhibitory effect was specific for ICC. Conclusions The selective

  2. [Effects of membrane protein ANO1 stable overexpression on laryngocarcinoma Hep-2 cells].

    PubMed

    Li, Ya-dong

    2014-02-01

    To explore the effects of ANO1 overexpression on the proliferation, detachment, spreading, and migration of laryngocarcinoma Hep-2 cell line. ANO1-overexpressing Hep-2 cell line was selected as the assay group, and Hep-2 cell line with empty plasmid was selected as the control group. MTT assay was used to detect the proliferation abilities of Hep-2 cells in both two groups. Cell detachment assay and spreading assay were used to detect the detachment and spreading abilities of Hep-2 cells. Boyden chamber invasion assay, wound healing assay in vitro, and niflumic acid block chloride channel were used to detect the migration abilities of Hep-2 cells. All data were analyzed by SPSS 10.0 software package. Cell proliferation assay by MTT showed that, compared with the control group, the optical density value of assay group was not significantly different (P=0.62). The results of cell detachment assay and cell spreading assay showed the cell detachment rates and cell spreading rates in assay group were significantly higher than those in control group (P<0.0001). The results of Boyden chamber invasion assay showed the percentages of cells migrating through the membrane in assay group were significantly higher than those in control group (P<0.0001). The results of in vitro wound healing experiments showed the wound area rate in assay group was significantly lower than that in control group (P<0.0001). The results of niflumic acid blocking chloride channel experiments showed the wound area rates in assay group were significantly higher than those in control group (P<0.0001). ANO1 overexpression does not remarkably alter the proliferation rate of cancer cells, but increases the migration, spreading, and detachment capacities of head and neck squamous cell carcinoma.

  3. ANOS1: a unified nomenclature for Kallmann syndrome 1 gene (KAL1) and anosmin-1.

    PubMed

    de Castro, Fernando; Seal, Ruth; Maggi, Roberto

    2016-11-29

    It is accepted that confusion regarding the description of genetic variants occurs when researchers do not use standard nomenclature. The Human Genome Organization Gene Nomenclature Committee contacted a panel of consultants, all working on the KAL1 gene, to propose an update of the nomenclature of the gene, as there was a convention in the literature of using the 'KAL1' symbol, when referring to the gene, but using the name 'anosmin-1' when referring to the protein. The new name, ANOS1, reflects protein name and is more transferrable across species.

  4. The Ca2+-activated Cl− channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis

    PubMed Central

    Qu, Zhiqiang; Yao, Weicheng; Yao, Ruyong; Liu, Xiangping; Yu, Kuai; Hartzell, Criss

    2014-01-01

    Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca2+-activated Cl− channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment. PMID:24639373

  5. A new period for AX UMa.

    NASA Astrophysics Data System (ADS)

    Boninsegna, R.

    1985-05-01

    In 1958, G. Romano photographically discovered AX UMa. He proposed a first ephemeris for this RRab-type variable, in 1964. During three seasons, ten maxima were recordd by three GEOS visual observers. The reduction of the observations clearly shows that the period found by Romano is no longer valid. The new elements proposed by this paper are as follows: Max = hel. JD 2,445,382.559(+/-6) + 0.53491(+/-1) E (95% confidence interval for the error bands).

  6. GHRS Observations of LISM towards eta UMa

    NASA Astrophysics Data System (ADS)

    Frisch, P. C.

    1998-01-01

    The star eta UMa (l=101(deg) , b=+65(deg) , d=31 pc) samples local interstellar matter (LISM) in a high latitude region. The Sun is ``above'' most of the mass of the Local Fluff cloud complex, yielding low total interstellar column densities towards eta UMa. Thus cloud properties can be determined with minimal confusion caused by velocity component blending in this sightline. The physical properties of the cloud surrounding the solar system become the boundary conditions of the solar system. A key property of the surrounding cloud is the proton density, since the Alfven velocity regulates the formation of a bow shock around the heliosphere, and since charge exchange between interstellar p(+) and H(deg) yields a pile-up of H(deg) at the heliopause. As a result, the interstellar electron density in the surrounding cloud is an important parameter in understanding the configuration of the outer heliosphere regions. We present GHRS Echelle A and Echelle B data on C({deg) *}, C(deg) , Mg(deg) and Mg(+) . These data allow us to compare electron densities as estimated from the ratios N(C({deg) *})/N(C(deg) ) versus N(Mg(deg) )/N(Mg(+) ) for a relatively simple sightline. These electron densities are also compared to electron densities determined from optical Ca(+) observations towards eta UMa by Frisch and Welty (in preparation).

  7. The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis.

    PubMed

    Ruppersburg, Chelsey Chandler; Hartzell, H Criss

    2014-06-01

    Many cells possess a single, nonmotile, primary cilium highly enriched in receptors and sensory transduction machinery that plays crucial roles in cellular morphogenesis. Although sensory transduction requires ion channels, relatively little is known about ion channels in the primary cilium (with the exception of TRPP2). Here we show that the Ca(2+)-activated Cl ((-)) channel anoctamin-1 (ANO1/TMEM16A) is located in the primary cilium and that blocking its channel function pharmacologically or knocking it down with short hairpin RNA interferes with ciliogenesis. Before ciliogenesis, the channel becomes organized into a torus-shaped structure ("the nimbus") enriched in proteins required for ciliogenesis, including the small GTPases Cdc42 and Arl13b and the exocyst complex component Sec6. The nimbus excludes F-actin and coincides with a ring of acetylated microtubules. The nimbus appears to form before, or independent of, apical docking of the mother centriole. Our data support a model in which the nimbus provides a scaffold for staging of ciliary components for assembly very early in ciliogenesis and chloride transport by ANO1/TMEM16A is required for the genesis or maintenance of primary cilia.

  8. Comparing Ksharasutra (Ayurvedic Seton) and open fistulotomy in the management of fistula-in-ano.

    PubMed

    Dutta, Gouranga; Bain, Jayanta; Ray, Ajay Kumar; Dey, Soumedhik; Das, Nandini; Das, Biswanath

    2015-01-01

    Most commonly practiced surgical "lay open" technique to treat fistula-in-ano (a common anorectal pathology) has high rate of recurrence and anal incontinence. Alternatively, a nonsurgical cost efficient treatment with Ksharasutra (cotton Seton coated with Ayurvedic medicines) has minimal complications. In our study, we have tried to compare these two techniques. A prospective randomized control study was designed involving patients referred to the Department of General Surgery in RG Kar Medical College, Kolkata, India, from January 2010 to September 2011. Among 50 patients, 26 were in Ksharasutra and 24 were in fistulotomy group. 86% patients were male and 54% of the patients were in the fourth decade. About 74% fistulas are inter-sphincteric and 26% were of trans-sphincteric variety. Severe postoperative pain was more (7.7% vs. 25%) in fistulotomy group, while wound discharge was more associated with Ksharasutra group (15.3% vs. 8.3%). Wound scarring, bleeding, and infection rate were similar in both groups. Ksharasutra group took more time to heal (mean: 53 vs. 35.7 days, P = 0.002) despite reduced disruption to their routine work (2.7 vs. 15.5 days work off, P <0.001). Interestingly, pain experienced was less in Ksharasutra group, there was no open wound in contrast to fistulotomy and it was significantly cost effective (Rupees 166 vs. 464). Treatment of fistula-in-ano with Ksharasutra is a simple with low complications and minimal cost.

  9. Ano1, a Ca2+-activated Cl− channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal

    PubMed Central

    Singh, Raman Deep; Gibbons, Simon J; Saravanaperumal, Siva Arumugam; Du, Peng; Hennig, Grant W; Eisenman, Seth T; Mazzone, Amelia; Hayashi, Yujiro; Cao, Chike; Stoltz, Gary J; Ordog, Tamas; Rock, Jason R; Harfe, Brian D; Szurszewski, Joseph H; Farrugia, Gianrico

    2014-01-01

    Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical activity to drive contractility in the gastrointestinal tract via ion channels. Ano1 (Tmem16a), a Ca2+-activated Cl− channel, is an ion channel expressed in ICC. Genetic deletion of Ano1 in mice resulted in loss of slow waves in smooth muscle of small intestine. In this study, we show that Ano1 is required to maintain coordinated Ca2+ transients between myenteric ICC (ICC-MY) of small intestine. First, we found spontaneous Ca2+ transients in ICC-MY in both Ano1 WT and knockout (KO) mice. However, Ca2+ transients within the ICC-MY network in Ano1 KO mice were uncoordinated, while ICC-MY Ca2+ transients in Ano1 WT mice were rhythmic and coordinated. To confirm the role of Ano1 in the loss of Ca2+ transient coordination, we used pharmacological inhibitors of Ano1 activity and shRNA-mediated knock down of Ano1 expression in organotypic cultures of Ano1 WT small intestine. Coordinated Ca2+ transients became uncoordinated using both these approaches, supporting the conclusion that Ano1 is required to maintain coordination/rhythmicity of Ca2+ transients. We next determined the effect on smooth muscle contractility using spatiotemporal maps of contractile activity in Ano1 KO and WT tissues. Significantly decreased contractility that appeared to be non-rhythmic and uncoordinated was observed in Ano1 KO jejunum. In conclusion, Ano1 has a previously unidentified role in the regulation of coordinated gastrointestinal smooth muscle function through coordination of Ca2+ transients in ICC-MY. PMID:25063822

  10. FLIP-FLOP ACTIVITY ON THE W UMa-TYPE BINARY SYSTEM HH UMa

    SciTech Connect

    Wang, Kun; Zhang, Xiaobin; Deng, Licai; Luo, Changqing; Luo, Yangping; Zhang, Jun

    2015-05-20

    We report the discovery of flip-flop activity in a W UMa-type binary. A long-term multi-color photometric surveillance of HH UMa was carried out with three sets of light curves obtained over six weeks. The light curves of the eclipsing binary presented marked asymmetry and rapid interchange between the two light maxima. During the observations from 2014 February to 2014 April, the spot distortion phase jumped between phases 0.25 and 0.75 twice, a typical indication of flip-flop activity. We applied the Wilson–Devinney method to analyze the three light curves. The results indicate that HH UMa is a partially eclipsing contact system of A subtype with an obviously asymmetric light curve. The observed light curves can be modeled by assuming that there are two dark spots on the massive primary component that are almost persistently located around phases 0.25 and 0.75, but can interchange their intensities. We further suggest that a plausible scenario for explaining the properties of those dark spots is strong surface magnetic activity with a sudden reversal of the more active longitude. We therefore conclude that HH UMa is very likely a W UMa-type system displaying flip-flop activity.

  11. Three novel ANO5 missense mutations in Caucasian and Chinese families and sporadic cases with gnathodiaphyseal dysplasia

    PubMed Central

    Jin, Lingling; Liu, Yi; Sun, Fanyue; Collins, Michael T.; Blackwell, Keith; Woo, Albert S.; Reichenberger, Ernst J.; Hu, Ying

    2017-01-01

    Gnathodiaphyseal dysplasia (GDD; MIM#166260) is an autosomal dominant syndrome with characteristic cemento-osseous lesions of jawbones, bone fragility, and diaphyseal sclerosis of tubular bones. To date, only five mutations in the proposed calcium-activated chloride channel ANO5/TMEM16E gene have been identified. In this study, we describe two families and two singular patients with three new mutations. One Caucasian family with seven affected members exhibited frequent bone fractures and florid osseous dysplasia (p.Cys356Tyr), while one Chinese family with two affected members suffered from cementoma and purulent osteomyelitis (p.Cys360Tyr). In addition, two different novel mutations (p.Gly518Glu and p.Arg215Gly) were identified in sporadic patients without family history. In vitro studies overexpressing GDD mutations (p.Cys356Tyr and p.Cys360Tyr) showed significantly reduced ANO5 protein. It appears that all GDD mutations known so far locate in an extracellular domain following the first transmembrane domain or in the 4th putative transmembrane domain. Both wild-type and mutant ANO5 protein localize to the endoplasmic reticulum. After Ano5 gene knock-down with shRNA in MC3T3-E1 osteoblast precursors we saw elevated expression of osteoblast-related genes such as Col1a1, osteocalcin, osterix and Runx2 as well as increased mineral nodule formation in differentiating cells. Our data suggest that ANO5 plays a role in osteoblast differentiation. PMID:28176803

  12. Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion.

    PubMed

    Xu, Zhixiong; Lefevre, Gaelle M; Gavrilova, Oksana; Foster St Claire, Mark B; Riddick, Gregory; Felsenfeld, Gary

    2014-11-25

    We used circular chromatin conformation capture (4C) to identify a physical contact in human pancreatic islets between the region near the insulin (INS) promoter and the ANO1 gene, lying 68 Mb away on human chromosome 11, which encodes a Ca(2+)-dependent chloride ion channel. In response to glucose, this contact was strengthened and ANO1 expression increased, whereas inhibition of INS gene transcription by INS promoter targeting siRNA decreased ANO1 expression, revealing a regulatory effect of INS promoter on ANO1 expression. Knockdown of ANO1 expression caused decreased insulin secretion in human islets, establishing a physical proximity-dependent feedback loop involving INS transcription, ANO1 expression, and insulin secretion. To explore a possible role of ANO1 in insulin metabolism, we carried out experiments in Ano1(+/-) mice. We observed reduced serum insulin levels and insulin-to-glucose ratios in high-fat diet-fed Ano1(+/-) mice relative to Ano1(+/+) mice fed the same diet. Our results show that determination of long-range contacts within the nucleus can be used to detect novel and physiologically relevant mechanisms. They also show that networks of long-range physical contacts are important to the regulation of insulin metabolism.

  13. Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer

    PubMed Central

    Jia, Linghan; Liu, Wen; Guan, Lizhao; Lu, Min; Wang, KeWei

    2015-01-01

    Lung cancer or pulmonary carcinoma is primarily derived from epithelial cells that are thin and line on the alveolar surfaces of the lung for gas exchange. ANO1/TMEM16A, initially identified from airway epithelial cells, is a member of Ca2+-activated Cl- channels (CaCCs) that function to regulate epithelial secretion and cell volume for maintenance of ion and tissue homeostasis. ANO1/TMEM16A has recently been shown to be highly expressed in several epithelium originated carcinomas. However, the role of ANO1 in lung cancer remains unknown. In this study, we show that inhibition of calcium-activated chloride channel ANO1/TMEM16A suppresses tumor growth and invasion in human lung cancer. ANO1 is upregulated in different human lung cancer cell lines. Knocking-down ANO1 by small hairpin RNAs inhibited proliferation, migration and invasion of GLC82 and NCI-H520 cancel cells evaluated by CCK-8, would-healing, transwell and 3D soft agar assays. ANO1 protein is overexpressed in 77.3% cases of human lung adenocarcinoma tissues detected by immunohistochemistry. Furthermore, the tumor growth in nude mice implanted with GLC82 cells was significantly suppressed by ANO1 silencing. Taken together, our findings provide evidence that ANO1 overexpression contributes to tumor growth and invasion of lung cancer; and suppressing ANO1 overexpression may have therapeutic potential in lung cancer therapy. PMID:26305547

  14. Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion

    PubMed Central

    Xu, Zhixiong; Lefevre, Gaelle M.; Gavrilova, Oksana; Foster St. Claire, Mark B.; Riddick, Gregory; Felsenfeld, Gary

    2014-01-01

    We used circular chromatin conformation capture (4C) to identify a physical contact in human pancreatic islets between the region near the insulin (INS) promoter and the ANO1 gene, lying 68 Mb away on human chromosome 11, which encodes a Ca2+-dependent chloride ion channel. In response to glucose, this contact was strengthened and ANO1 expression increased, whereas inhibition of INS gene transcription by INS promoter targeting siRNA decreased ANO1 expression, revealing a regulatory effect of INS promoter on ANO1 expression. Knockdown of ANO1 expression caused decreased insulin secretion in human islets, establishing a physical proximity-dependent feedback loop involving INS transcription, ANO1 expression, and insulin secretion. To explore a possible role of ANO1 in insulin metabolism, we carried out experiments in Ano1+/− mice. We observed reduced serum insulin levels and insulin-to-glucose ratios in high-fat diet–fed Ano1+/− mice relative to Ano1+/+ mice fed the same diet. Our results show that determination of long-range contacts within the nucleus can be used to detect novel and physiologically relevant mechanisms. They also show that networks of long-range physical contacts are important to the regulation of insulin metabolism. PMID:25385647

  15. Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer.

    PubMed

    Jia, Linghan; Liu, Wen; Guan, Lizhao; Lu, Min; Wang, KeWei

    2015-01-01

    Lung cancer or pulmonary carcinoma is primarily derived from epithelial cells that are thin and line on the alveolar surfaces of the lung for gas exchange. ANO1/TMEM16A, initially identified from airway epithelial cells, is a member of Ca2+-activated Cl- channels (CaCCs) that function to regulate epithelial secretion and cell volume for maintenance of ion and tissue homeostasis. ANO1/TMEM16A has recently been shown to be highly expressed in several epithelium originated carcinomas. However, the role of ANO1 in lung cancer remains unknown. In this study, we show that inhibition of calcium-activated chloride channel ANO1/TMEM16A suppresses tumor growth and invasion in human lung cancer. ANO1 is upregulated in different human lung cancer cell lines. Knocking-down ANO1 by small hairpin RNAs inhibited proliferation, migration and invasion of GLC82 and NCI-H520 cancel cells evaluated by CCK-8, would-healing, transwell and 3D soft agar assays. ANO1 protein is overexpressed in 77.3% cases of human lung adenocarcinoma tissues detected by immunohistochemistry. Furthermore, the tumor growth in nude mice implanted with GLC82 cells was significantly suppressed by ANO1 silencing. Taken together, our findings provide evidence that ANO1 overexpression contributes to tumor growth and invasion of lung cancer; and suppressing ANO1 overexpression may have therapeutic potential in lung cancer therapy.

  16. Fistula Plug in Fistulising Ano-Perineal Crohn's Disease: a Randomised Controlled Trial.

    PubMed

    Senéjoux, A; Siproudhis, L; Abramowitz, L; Munoz-Bongrand, N; Desseaux, K; Bouguen, G; Bourreille, A; Dewit, O; Stefanescu, C; Vernier, G; Louis, E; Grimaud, J C; Godart, B; Savoye, G; Hebuterne, X; Bauer, P; Nachury, M; Laharie, D; Chevret, S; Bouhnik, Y

    2016-02-01

    Anal fistula plug [AFP] is a bioabsorbable bioprosthesis used in ano-perineal fistula treatment. We aimed to assess efficacy and safety of AFP in fistulising ano-perineal Crohn's disease [FAP-CD]. In a multicentre, open-label, randomised controlled trial we compared seton removal alone [control group] with AFP insertion [AFP group] in 106 Crohn's disease patients with non- or mildly active disease having at least one ano-perineal fistula tract drained for more than 1 month. Patients with abscess [collection ≥ 3mm on magnetic resonance imaging or recto-vaginal fistulas were excluded. Randomisation was stratified in simple or complex fistulas according to AGA classification. Primary end point was fistula closure at Week 12. In all, 54 patients were randomised to AFP group [control group 52]. Median fistula duration was 23 [10-53] months. Median Crohn's Disease Activity Index at baseline was 81 [45-135]. Fistula closure at Week 12 was achieved in 31.5% patients in the AFP group and in 23.1 % in the control group (relative risk [RR] stratified on AGA classification: 1.31; 95% confidence interval: 0.59-4.02; p = 0.19). No interaction in treatment effect with complexity stratum was found; 33.3% of patients with complex fistula and 30.8% of patients with simple fistula closed the tracts after AFP, as compared with 15.4% and 25.6% in controls, respectively [RR of success = 2.17 in complex fistula vs RR = 1.20 in simple fistula; p = 0.45]. Concerning safety, at Week 12, 17 patients developed at least one adverse event in the AFP group vs 8 in the controls [p = 0.07]. AFP is not more effective than seton removal alone to achieve FAP-CD closure. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  17. Modular condenser replacement at ANO-1 solves operating problems and improves performance

    SciTech Connect

    Edgell, D.; Davidian, A.

    1999-07-01

    After 22 years of operation, the condenser tube bundles and waterboxes at Arkansas Nuclear One, Unit 1 (ANO-1) had deteriorated significantly, impairing operating performance, reducing condenser reliability and increasing maintenance cost. An extensive condition assessment performed in 1995 revealed a 34% wall loss on the original Admiralty tubing and an erosion rate of 1.7% annually. Additionally, Arkansas Nuclear One was considering an 8% power uprate, which would place additional duty on the main condenser. As a result, it was decided to completely reconstruct the four condenser tube bundles serving the two low-pressure turbines at Arkansas Nuclear One. An evaluation of the available condenser tube materials was performed to determine which material was best suited for service in the single pass, single pressure condenser at ANO-1. All copper based materials were excluded from consideration due to the detrimental effect copper has on secondary chemistry and more specifically steam generator integrity. Titanium and a variety of stainless steel materials were evaluated, and ultimately titanium was selected as the replacement condenser tube material for the rebuilt condenser tube bundles due primarily to its corrosion resistance and extensive operating experience in condenser service. An impressed current cathodic protection system and epoxy waterbox coating was also installed to prevent galvanic corrosion of the carbon steel waterboxes. The cathodic protection system included local alarm indication to alert plant operating staff of any system malfunction that could result in titanium hydrating. A comparison of the heat transfer characteristics of the existing condenser design with Admiralty tubes and a new tube bundle design with titanium tubes concluded that a new tube bundle design was required to optimize the condenser performance and accommodate the anticipated 8% power uprate. This paper will discuss the condenser optimization program from the design state to

  18. Comparing Ksharasutra (Ayurvedic Seton) and open fistulotomy in the management of fistula-in-ano

    PubMed Central

    Dutta, Gouranga; Bain, Jayanta; Ray, Ajay Kumar; Dey, Soumedhik; Das, Nandini; Das, Biswanath

    2015-01-01

    Background: Most commonly practiced surgical “lay open” technique to treat fistula-in-ano (a common anorectal pathology) has high rate of recurrence and anal incontinence. Alternatively, a nonsurgical cost efficient treatment with Ksharasutra (cotton Seton coated with Ayurvedic medicines) has minimal complications. In our study, we have tried to compare these two techniques. Materials and Methods: A prospective randomized control study was designed involving patients referred to the Department of General Surgery in RG Kar Medical College, Kolkata, India, from January 2010 to September 2011. Results: Among 50 patients, 26 were in Ksharasutra and 24 were in fistulotomy group. 86% patients were male and 54% of the patients were in the fourth decade. About 74% fistulas are inter-sphincteric and 26% were of trans-sphincteric variety. Severe postoperative pain was more (7.7% vs. 25%) in fistulotomy group, while wound discharge was more associated with Ksharasutra group (15.3% vs. 8.3%). Wound scarring, bleeding, and infection rate were similar in both groups. Ksharasutra group took more time to heal (mean: 53 vs. 35.7 days, P = 0.002) despite reduced disruption to their routine work (2.7 vs. 15.5 days work off, P <0.001). Interestingly, pain experienced was less in Ksharasutra group, there was no open wound in contrast to fistulotomy and it was significantly cost effective (Rupees 166 vs. 464). Conclusion: Treatment of fistula-in-ano with Ksharasutra is a simple with low complications and minimal cost. PMID:26283840

  19. Comparative study of Ksharasutra suturing and Lord's anal dilatation in the management of Parikartika (chronic fissure-in-ano)

    PubMed Central

    Dudhamal, Tukaram S.; Baghel, Madhav Singh; Bhuyan, Chaturbhuja; Gupta, Sanjay Kumar

    2014-01-01

    Background: Parikartika resembles fissure-in-ano which is very common among all ano-rectal disorders. In Ayurvedic texts, Parikartika is described as a complication of Vamana and Virechana as well as complication of Atisara. Ksharasutra was proved successful in the management of fistula-in-ano, piles, and there is a need to try its efficacy in fissure-in-ano. Aim: To evaluate the role of Ksharasutra suturing (KSS) in fissure bed in chronic fissure-in-ano. Materials and Methods: Total 100 patients of chronic fissure-in-ano were selected and randomly divided into two groups (50 in each group). In group-A, patients were undergone by KSS; while in patients of Group-B Lord's anal dilatation followed by KSS was done under spinal anesthesia. The KSS was done once and after slough out of Ksharasutra, the wound was treated for 4 weeks and assessment of the result was done on the basis of gradation adopted. Results: The pain relief on 14th day in Group-A was 86% while in Group-B 100% was observed. As on 7th day in Group-A, oozing was stopped in 68% patients, while in Group-B, oozing was stopped in 82% patients. On 21st day, Group-B showed more healing (85%) as compared to Group-A (69%). In this study 68% of patients were cured. Conclusion: In Group-B (KSS with Lord's anal dilatation) patients were cured early as compared to patients of Group-A (KSS alone). PMID:25558158

  20. High speed photometry of AN UMa

    SciTech Connect

    Imamura, J.N.; Steiman-Cameron, T.Y.; Durisen, R.H.

    1985-01-01

    As a class, the AM Her objects exhibit temporal variability on time scales ranging from seconds to years. Most of the variations can be adequately described by ''shot noise'' models (Cordova and Mason 1982). Exceptions to this are the strictly periodic features modulated on the orbital periods of the systems (typically several hours) and the one to two second features which show up as ''excesses'' of power in the time averaged power spectra of AN UMa (Middleditch 1982) and E1405-451 (Mason et al. 1983; Larsson 1985). It has been suggested that the short time scale features are due to an oscillatory ''instability'' of radiative accretion shocks discovered by Langer, Chanmugam, and Shaviv (1981, 1982). This is an interesting suggestion because, if true, it would allow the masses of the accreting white dwarfs to be inferred and would provide other significant constraints on the physics of the accretion flows (see Langer et al. 1981, 1982; Chevalier and Imamura 1982; Imamura, Wolff, and Durisen 1984; Imamura 1985). Unfortunately, a direct physical relationship between the one to two second optical variations and shock oscillations has not yet been demonstrated. Because of the potential importance of such a result further study of these systems is clearly warranted. In this work, we examine the short time scale behavior of AN UMa in more detail and improve on the work of Middleditch (1982) by resolving the feature in time.

  1. Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca(2+) transients and slow waves in adult mouse small intestine.

    PubMed

    Malysz, John; Gibbons, Simon J; Saravanaperumal, Siva A; Du, Peng; Eisenman, Seth T; Cao, Chike; Oh, Uhtaek; Saur, Dieter; Klein, Sabine; Ordog, Tamas; Farrugia, Gianrico

    2017-03-01

    Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit(+) electrical pacemakers that express the Ano1/TMEM16A Ca(2+)-activated Cl(-) channel, whose functions in the gastrointestinal tract remain incompletely understood. In this study, an inducible Cre-LoxP-based approach was used to advance the understanding of Ano1 in ICC-MY of adult mouse small intestine. Kit(CreERT2/+);Ano1(Fl/Fl) mice were treated with tamoxifen or vehicle, and small intestines (mucosa free) were examined. Quantitative RT-PCR demonstrated ~50% reduction in Ano1 mRNA in intestines of conditional knockouts (cKOs) compared with vehicle-treated controls. Whole mount immunohistochemistry showed a mosaic/patchy pattern loss of Ano1 protein in ICC networks. Ca(2+) transients in ICC-MY network of cKOs displayed reduced duration compared with highly synchronized controls and showed synchronized and desynchronized profiles. When matched, the rank order for Ano1 expression in Ca(2+) signal imaged fields of view was as follows: vehicle controls>cKO(synchronized)>cKO(desynchronized). Maintenance of Ca(2+) transients' synchronicity despite high loss of Ano1 indicates a large functional reserve of Ano1 in the ICC-MY network. Slow waves in cKOs displayed reduced duration and increased inter-slow-wave interval and occurred in regular- and irregular-amplitude oscillating patterns. The latter activity suggested ongoing interaction by independent interacting oscillators. Lack of slow waves and depolarization, previously reported for neonatal constitutive knockouts, were also seen. In summary, Ano1 in adults regulates gastrointestinal function by determining Ca(2+) transients and electrical activity depending on the level of Ano1 expression. Partial Ano1 loss results in Ca(2+) transients and slow waves displaying reduced duration, while complete and widespread absence of Ano1 in ICC-MY causes lack of slow wave and desynchronized Ca(2+) transients.NEW & NOTEWORTHY The Ca(2+)-activated

  2. [Strategies on perianal abscess and fistula-in-ano: interpretation of the guidelines from USA and German].

    PubMed

    Ding, Shu-qing; Ding, Yi-jiang

    2012-12-01

    The Practice Parameters for the Management of Perianal Abscess and Fistula-in-ano from USA(2011) and German guidelines for anal abscess (2012) are based on the evidence and specialists consensus from colorectal field. Standardization of the anal abscess management may simplify the anal fistula treatment. This review is to concepts from other countries and guide the treatment in China.

  3. Randomized controlled pilot trial of nifedipine as oral therapy vs. topical application in the treatment of fissure-in-ano.

    PubMed

    Agrawal, Vivek; Kaushal, Gourav; Gupta, Rachna

    2013-11-01

    Fissure-in-ano is a common condition that leads to pain and affects quality of life. Sphincterotomy remains the gold standard, but it may lead to troublesome incontinence in some patients. To overcome this problem, numerous pharmacologic therapies have been tested with varying outcomes. The investigators compared the effect of the addition of oral and topical nifedipine to conservative measures in the treatment of patients with fissure-in-ano. Ninety patients with fissure-in-ano, randomized into 3 groups of 30 each, were included in the study. Group I received conventional treatment, group II received oral nifedipine and conventional treatment, and group III received topical nifedipine along with conventional treatment. Patients were followed for 8 weeks for pain relief (assessed using a visual analogue scale) and healing to evaluate the effect of treatment. Pain relief was significantly better in the group III at 3 weeks and 2 months compared with group I (P < .05). Groups II and III were comparable in terms of pain relief. Healing rates were significantly better in group II (P = .03) and group III (P = .00) compared with group I, but groups II and III were found to be comparable. Adverse effects were most commonly reported by group II patients, but these were not significantly higher than in other 2 groups. We recommend the addition of either oral or topical nifedipine to conservative measures to significantly improve pain relief and healing rates in patients with fissure-in-ano. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. The proposed use of radiofrequency ablation for the treatment of fistula-in-ano.

    PubMed

    Keogh, Kenneth M; Smart, Neil J

    2016-01-01

    Fistula in ano is a very common presentation to colorectal clinic. Embarrassment due to the symptoms makes accurate estimations of incidence difficult. It is estimated that up to 40% of peri-anal abscess will be accompanied by or preceded by a fistula. Fistulae can be classified into simple fistulae that involve no or minimal sphincter muscle and complex, which involve significant amounts of the anal sphincter muscle, possibly with multiple tracts. For complex fistulae a seton suture is usually placed through the tract and out through the anus to form a loop allowing pockets of sepsis to drain internally and externally and a mature tract of fibrous tissue to develop. Following this period definitive fistula treatment is considered. This can involve a number of procedures that have tremendously varied success rates in the literature. The first stage of surgical treatment is often a core fistulectomy, which entails surgical removal of the tract. This may be followed by insertion of fibrin glue, a collagen plug or formation of a rotation skin flap from surrounding tissue in order to close the resultant tissue defect. All current treatments have a significant failure rate. If this wound breaks down the surgery can leave a large painful peri-anal wound that can lead to ongoing fistulation. Should this occur resiting of the seton will be required with the patient only getting back to square one after months of healing around the seton. In addition removing cores of fibrous tissue passing through the sphincter can threaten the sphincter function resulting in impaired continence. Having seen radiofrequency ablation used to close varicose veins the authors propose that one could use similar techniques to close a fibrous tract matured with a seton in order to close a fistula. The authors propose that a short length radiofrequency catheter could be used to treat fistula in ano. This would in theory be less painful with less tissue destruction. In addition there would be no

  5. The anal fistula plug in Crohn's disease patients with fistula-in-ano: a systematic review.

    PubMed

    Nasseri, Y; Cassella, L; Berns, M; Zaghiyan, K; Cohen, J

    2016-04-01

    This study aimed to review, consolidate and analyse the findings of studies investigating the efficacy of anal fistula plugs (AFPs) in treating fistula-in-ano in patients with Crohn's disease. A literature review was conducted via Pubmed, Embase, Medline, Scopus and the Cochrane Library for the period 1995-2015. Articles were selected and reviewed based on specific inclusion and exclusion criteria. A total of 16 studies were extracted, of which 12 were included in the systematic review. In total, 84 patients (n = 1-20 per study) with a median age of 45 (18-72) years and a median follow-up time of 9 (3-24) months were analysed. The total success rate, defined as closure of the fistula tract, was 49/84 (58.3%, 95% CI 47-69). Success in patients with recurrent anal fistulae was 2/5 (40%, 95% CI 5-85). Overall, the success rates of Surgisis and GORE BIO-A brand plugs were 48/80 (60%, 95% CI 48-71) and 1/4 (25%, 95% CI 1-81). The recurrence rate of fistula-in-ano in the five studies that reported recurrence was 3/22 (13.6%). In two comparative studies, inferior overall success rates were found in patients who received preoperative immunomodulators vs. those who did not [3/11 (27.3%) vs. 17/23 (73.9%)]. The studies suggest that the use of an AFP in patients with Crohn's disease is a safe procedure with reasonable success, little morbidity and a low risk of incontinence. The current literature is limited by a number of factors, including small study cohorts, grouping of fistulae in Crohn's disease with other types of anal fistula, short and highly variable follow-up times and multiple confounding factors such as number of fistula tracts, use of preoperative steroids or immunosuppressants, previous use of setons and variation in surgical technique. Colorectal Disease © 2016 The Association of Coloproctology of Great Britain and Ireland.

  6. Fistulotomy versus fistulectomy for simple fistula in ano: a retrospective cohort study.

    PubMed

    Murtaza, Ghulam; Shaikh, Fareed Ahmed; Chawla, Tabish; Rajput, Batool Urooj; Shahzad, Noman; Ansari, Sumaiya

    2017-03-01

    To compare fistulotomy with fistulectomy for wound healing, duration of surgery, post-operative pain, incontinence and recurrence in patients with fistula in ano. This retrospective cohort study was conducted at the Aga Khan University Hospital, Karachi, and comprised data of adults who had undergone fistulotomy/fistulectomy for simple fistula in ano from January 2007 to August 2012. Data collection was done in August 2013 using questionnaire and telephonic interviews. Outcome variables like duration of wound healing, recurrence, incontinence, duration of surgery and post-operative pain were compared in both the groups. SPSS 19 was used for data analysis. Of the 192 cases, there were 96(50%) in each group. The mean age was 40.51 years (range: 21-72 years) in the fistulotomy group and 41.14 years (range: 21-66 years) in the fistulectomy group (p=0.66). Both groups were comparable for baseline demographic variables. The median duration of wound healing was shorter in the fistulotomy group 15 days (Interquartile range: 7-20 days) compared to the fistulectomy group 30 days (Interquartile range: 15-42 days) (p<0.001). The incidence of recurrence was comparable in fistulotomy vs. fistulectomy (3[3.12%] vs. 4[4.16%]; p=0.70). The incidence of incontinence was higher in fistulotomy compared to fistulectomy (5[5.3%] vs. 12[12.5%]; p=0.07). The severity of incontinence was also compared but the difference was insignificant (p=0.06). The median duration of surgery was significantly shorter in fistulotomy group 17 minutes (Interquartile range: 12-25 minutes) compared to fistulectomy group 25 minutes Interquartile range: 20-35 minutes (p<0.001). The median post-operative pain in the surgical day care unit and at the first follow-up in clinic was zero for both groups. Fistulotomy yielded better results than fistulectomy since it significantly decreased the duration of wound healing and duration of surgery without increasing the incidence of recurrence, incontinence and post

  7. UZ UMa: An RRab star with double-periodic modulation

    NASA Astrophysics Data System (ADS)

    Sodor, A.; Vida, K.; Jurcsik, J.; Varadi, M.; Szeidl, B.; Hurta, Zs.; Dekany, I.; Posztobanyi, K.; Vityi, N.; Szing, A.; Kuti, A.; Lakatos, J.; Nagy, I.; Dobos, V.

    2006-05-01

    Our CCD V observations show that the fundamental mode RR Lyrae star UZ UMa displays double periodic Blazhko modulation of its light curve. The Blazhko periods are 26.7 and approx. 143 days. UZ UMa is estimated to be a relatively metal poor RRab star with [Fe/H]=-1.2.

  8. Efficacy of an anal fistula plug for fistulas-in-Ano in children.

    PubMed

    Kouchi, Katsunori; Takenouchi, Ayao; Matsuoka, Aki; Yabe, Kiyoaki; Korai, Mashahiro; Nakata, Chikako

    2017-08-01

    In children, perianal abscesses have a good prognosis and often heal with age. However, some perianal abscesses are refractory to treatment and remain as fistulas-in-Ano. Treatment with a Surgisis Anal Fistula Plug® has been reported as a new method of treatment for fistulas. In adults, the plug has been reported to cause little pain and have a high cure rate, but there have been no reported cases of its use in children. This study was designed to analyze the efficacy of the plug for closure of refractory fistulas in children. Since the plug has not been approved as a medical device in Japan, application for its use was submitted to the ethics committee of our university, and approval was granted, marking the first use of the plug in Japan. We classified refractory fistulas as those treated for 6months or longer and remaining unhealed, even after 1year of age, despite continued conservative treatment. The plug was used in 11 refractory fistulas in 8 children. Eight of 11 fistulas (72.7%) were successfully treated. Three fistulas recurred, and fistulectomies were performed. No sequelae were observed after AFP treatment. The plug was effective even for closure of refractory fistulas without sequelae in children. Treatment Study, Level IV. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Effect of boric acid treatment on the secondary cycle at ANO-2. Final report

    SciTech Connect

    Siegwarth, D.P.; McNea, D.A.; Sawochka, S.G.

    1985-11-01

    Because of the rapid progression of denting at the steam generator upper support plates at Arkansas Nuclear One-Unit 2 (ANO-2), Arkansas Power and Light (AP and L) implemented boric acid treatment during the third fuel cycle. Minimal effects of boric acid on secondary cycle ionic transport were observed; however, indications of accelerated corrosion of copper alloys in portions of the cycle were noted. Since the primary-to-secondary hydrogen diffusion rate data did not conform to the relation expected based on laboratory studies with Alloy 600, hydrogen transport data could not be employed to conclusively demonstrate the effect of boric acid on steam generator corrosion. Assuming that the basic form of the diffusion relation remained the same during operation with and without boric acid, a net increase in corrosion-generated hydrogen transport appeared to result from the adoption of boric acid treatment. This increase may be attributable to an increase in secondary cycle copper alloy corrosion rates, although additional measurements would be required to confirm this hypothesis.

  10. Sphincterotomy with radio frequency surgery: a new treatment technique of fissure in ano and associated pathologies.

    PubMed

    Gupta, Pravin J

    2003-03-01

    Anal fissures are dealt with using traditional approaches aiming at relieving the anal spasm and minimizing the anal sphincter pressure. Nevertheless, pathologies like sentinel tags, anal papillae, anal polyps, or small hemorrhoids which are often associated with chronic fissures are either considered innocuous, therefore left untreated, or are removed by conventional techniques. In this retrospective, non-randomized study, we performed lateral internal sphincterotomy, which was followed by radio frequency surgical procedures to eliminate the associated pathologies mentioned above. In all, 283 patients were studied. All the patients treated by the method of lateral subcutaneous internal sphincterotomy followed by radio frequency surgical procedure for aforesaid associated pathologies were made comfortable on account of the reduction in pain and irritation during defecation, the pricking or foreign body sensation in the anus and pruritus or wetness around the anal verge. A follow up after 18 months showed that only 7 % of patients had recurrence of symptoms or local signs. This combined approach has been found to be an effective, easy and quick way of treating chronic fissure in ano with associated pathologies

  11. Life Cycle Assessment of the MBT plant in Ano Liossia, Athens, Greece

    SciTech Connect

    Abeliotis, Konstadinos; Kalogeropoulos, Alexandros; Lasaridi, Katia

    2012-01-15

    Highlights: Black-Right-Pointing-Pointer We model the operation of an MBT plant in Greece based on LCA. Black-Right-Pointing-Pointer We compare four different MBT operating scenarios (among them and with landfilling). Black-Right-Pointing-Pointer Even the current operation of the MBT plant is preferable to landfilling. Black-Right-Pointing-Pointer Utilization of the MBT compost and metals generates the most environmental gains. Black-Right-Pointing-Pointer Thermal exploitation of RDF improves further the environmental performance of the plant. - Abstract: The aim of this paper is the application of Life Cycle Assessment to the operation of the MBT facility of Ano Liossia in the region of Attica in Greece. The region of Attica is home to almost half the population of Greece and the management of its waste is a major issue. In order to explicitly analyze the operation of the MBT plant, five scenarios were generated. Actual operation data of the MBT plant for the year 2008 were provided by the region of Attica and the LCA modeling was performed via the SimaPro 5.1 software while impact assessment was performed utilizing the Eco-indicator'99 method. The results of our analysis indicate that even the current operation of the MBT plant is preferable to landfilling. Among the scenarios of MBT operation, the one with complete utilization of the MBT outputs, i.e. compost, RDF, ferrous and non-ferrous metals, is the one that generates the most environmental gains. Our analysis indicates that the exploitation of RDF via incineration is the key factor towards improving the environmental performance of the MBT plant. Our findings provide a quantitative understanding of the MBT plant. Interpretation of results showed that proper operation of the modern waste management systems can lead to substantial reduction of environmental impacts and savings of resources.

  12. ANO10 c.1150_1151del is a founder mutation causing autosomal recessive cerebellar ataxia in Roma/Gypsies.

    PubMed

    Chamova, Teodora; Florez, Laura; Guergueltcheva, Velina; Raycheva, Margarita; Kaneva, Radka; Lochmüller, Hanns; Kalaydjieva, Luba; Tournev, Ivailo

    2012-05-01

    A recent report (Vermeer et al. in Am J Hum Genet 87:813-819, 2010) implicated for the first time the ANO10 gene in the genetic basis of autosomal recessive cerebellar ataxias. One of the three described families were Roma/Gypsies from Serbia, where the affected individuals were homozygous for the truncating p.Leu384fs mutation and displayed distinct phenotypic features (Vermeer et al. in Am J Hum Genet 87:813-819, 2010). Based on the history and population genetics of the Roma/Gypsies, we hypothesised that p.Leu384fs could be another founder mutation in this population, whose identification in a larger number of genetically homogeneous patients will contribute to defining the phenotypic spectrum of the disorder. Here, we describe additional patients from neighbouring Bulgaria, outlining invariable ANO10-ataxia features and confirming global intellectual decline as part of the phenotype resulting from complete Anactomin 10 deficit.

  13. Fistulotomy and sphincter reconstruction in the treatment of complex fistula-in-ano: long-term clinical and manometric results.

    PubMed

    Arroyo, Antonio; Pérez-Legaz, Juan; Moya, Pedro; Armañanzas, Laura; Lacueva, Javier; Pérez-Vicente, Francisco; Candela, Fernando; Calpena, Rafael

    2012-05-01

    To evaluate the long-term clinical and manometric results of fistulotomy and sphincter reconstruction for the treatment of complex fistula-in-ano. Complex fistula-in-ano is difficult to treat due to the occurrence of postoperative anal incontinence and the high rate of recurrence. Seventy patients who were diagnosed with complex fistula-in-ano and underwent fistulotomy and sphincter reconstruction between October 2000 and October 2006 were analyzed in the present study. Preoperative assessment included physical examination, anorectal manometry, and anal endosonography. Appointments were scheduled every 6 months during the first and second year of treatment and every 2 years thereafter. Recurrence and incontinence were evaluated during each visit. Continence was assessed according to the Wexner continence grading scale. Anal manometry was performed 3 and 12 months after treatment and every 2 years thereafter. Anal endosonography was conducted 6 months after treatment. Fistulas were classified as medium-high trans-sphincteric in 64 patients (91.42%) and were recurrent in 22 patients (32%). Before surgery, 22 patients (32%) reported fecal incontinence, which improved after surgery in 15 cases (70%), from 6.75 to 1.88 (P < 0.005) on the Wexner Scale. Eight preoperative continent patients (16.6%) reported postoperative incontinence (Wexner Score < 3), and 6 patients (8.5%) had recurrent incontinence. Among these patients, 2 developed recurrent incontinence 6 months after treatment, 2 developed recurrent incontinence 1 year after treatment, 1 developed recurrent incontinence 2 years after treatment, and 1 developed incontinence 5 years after treatment. Fistulotomy with sphincter reconstruction is an effective technique for the treatment of complex fistula-in-ano. Continence and anal manometry results were improved in incontinent patients and were not jeopardized in continent ones. Fistulotomy with sphincter reconstruction is an especially suitable technique for

  14. Quantification of landfill emissions to air: a case study of the Ano Liosia landfill site in the greater Athens area.

    PubMed

    Paraskaki, Ioanna; Lazaridis, Mihalis

    2005-06-01

    Fugitive pollutant emissions from municipal solid waste landfills have the potential to cause annoyance and health impacts in the surrounding residential areas. The overall objective of this research was to perform an assessment of fugitive pollutant emissions and a dispersion analysis downwind of a specific landfill site. The study was performed at the closed Ano Liosia landfill site which is located in the greater Athens area. The human exposure from priority to health-risk pollutants emitted from landfill, such as vinyl chloride and benzene, was estimated by the landfill gas emission LandGEM 2.01 software combined with the atmospheric long-term dispersion model ISC3-LT. The emission and meteorological conditions under which the models were applied referred to the worst-case scenario. This scenario was used for the evaluation of the maximum human exposure assessed beyond the Ano Liosia landfill towards the residential areas. The above scenario provides the minimum downwind distance of the health-risk zone which is calculated to be equal to 1.5 km from the landfill. Within this distance the assessed air pollutant concentration for several air pollutants was significantly above the World Health Organization reference lifetime exposure health criteria. Finally, the applied methodology was used in the Ano Liosia landfill, where atmospheric concentrations of pollutants measured in the field were compared with model predictions.

  15. [Analysis in pulmonary ventilatory function from 100 patients with ano-rectal diseases caused by deficiency of qi].

    PubMed

    Wang, W

    1999-03-01

    To explore the pathogenesis of ano-rectal diseases caused by deficiency of Qi, which is correlated with obstruction of pulmonary ventilation. The pulmonary ventilatory function was measured in 100 patients with the internal piles, the interno-external hemorrhoid and prolapse of rectum, the prolapse of anus was the principal symptom of them. Data from the 100 patients showed that 67% of them were diagnosed with the obstruction of pulmonary ventilation, the ratio was far less in the health control group. FEV 1.0 (mean +/- s) (2011.65 +/- 875) ml, MMF (1.84 +/- 1.24) L/s and PEF (2.34 +/- 1.51) L/s in male patients, (1551.54 +/- 514) ml, (1.57 +/- 0.62) L/s and (1.85 +/- 0.92) L/s in female patients, but those values were higher in the control than in the patients. The statistical analysis was performed and the difference was significant between patients and the control group (P < 0.01). The patients with ano-rectal diseases caused by deficiency of Qi accompanied with obstruction of pulmonary ventilation in different degree and varied sorts, it confirmed that the pathogenesis of ano-rectal diseases caused by deficiency of Qi is related with "sinking of pectoral Qi".

  16. A Japanese male with a novel ANO5 mutation with minimal muscle weakness and muscle pain till his late fifties.

    PubMed

    Kadoya, Masato; Ogata, Katsuhisa; Suzuki, Mikiya; Honma, Yutaka; Momma, Kazunari; Yatabe, Kana; Tamura, Takuhisa; Kaida, Kenichi; Miyata, Naomasa; Nishino, Ichizo; Nonaka, Ikuya; Kawai, Mitsuru

    2017-05-01

    Limb girdle muscular dystrophy type 2L (LGMD2L) is an adult-onset slowly progressive muscular dystrophy associated with anoctamin 5 (ANO5) gene mutation, mainly reported from Northern and Central Europe. We report the case of a Japanese male patient with a novel homozygous mutation of c.2394dup, p.Arg799Thrfs in ANO5 gene, the second patient in the Asian population. He had had marked elevation of creatine kinase (CK) level for more than 10 years with minimal muscular symptoms consisting of muscle stiffness and occasional cramps, preceding the onset of proximal limb weakness. Calf hypertrophy and selective fatty replacement of the adductor magnus and gastrocnemius muscles were prominent clinical and muscle imaging features. This case suggests that LGMD2L may affect a broader population than has been previously thought, physicians should consider the possibility of ANO5 mutation even in patients showing elevated CK level with no apparent muscle weakness but muscle stiffness or cramps. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture.

    PubMed

    Loera-Valencia, Raúl; Wang, Xuan-Yu; Wright, George W J; Barajas-López, Carlos; Huizinga, Jan D

    2014-12-01

    The interstitial cells of Cajal (ICC) drive the slow wave-associated contractions in the small intestine. A commonly used marker for these cells is c-Kit, but another marker named Ano1 was recently described. This study uses single-cell RT-PCR, qPCR and immunohistochemistry to determine if Ano1 could be reliably used as a molecular marker for ICC in single-cell mRNA analysis. Here, we report on the relationship between the expression of c-Kit and Ano1 in single ICC in culture. We observed that Ano1 is expressed in more than 60% of the collected cells, whereas c-Kit is found only in 22% of the cells (n = 18). When we stained ICC primary cultures for c-KIT and ANO1 protein, we found complete co-localization in all the preparations. We propose that this difference is due to the regulation of c-Kit mRNA in culture. This regulation gives rise to low levels of its transcript, while Ano1 is expressed more prominently in culture on day 4. We also propose that Ano1 is more suitable for single-cell expression analysis as a marker for cell identity than c-Kit at the mRNA level. We hope this evidence will help to validate and increase the success of future studies characterizing single ICC expression patterns.

  18. Activation of the Cl− Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor*

    PubMed Central

    Jin, Xin; Shah, Shihab; Liu, Yani; Zhang, Huiran; Lees, Meredith; Fu, Zhaojun; Lippiat, Jonathan D.; Beech, David J.; Sivaprasadarao, Asipu; Baldwin, Stephen A.; Zhang, Hailin; Gamper, Nikita

    2014-01-01

    We report that ANO1 (also known as TMEM16A) Ca2+-activated Cl− channels in small neurons from dorsal root ganglia are preferentially activated by particular pools of intracellular Ca2+. These ANO1 channels can be selectively activated by the G protein-coupled receptor (GPCR)-induced release of Ca2+ from intracellular stores, but not by Ca2+ influx through voltage-gated Ca2+ channels. This ability to discriminate between Ca2+ pools was achieved by the tethering of ANO1-containing plasma membrane domains, which also contained GPCRs such as bradykinin receptor-2 and protease-activated receptor-2, to juxtamembrane regions of the endoplasmic reticulum. Interaction of the C-terminus and the first intracellular loop of ANO1 with IP3R1 (inositol 1,4,5-trisphosphate receptor 1) contributed to the tethering. Disruption of membrane microdomains blocked the ANO1 and IP3R1 interaction and resulted in the loss of coupling between GPCR signaling and ANO1. The junctional signaling complex enabled ANO1-mediated excitation in response to specific Ca2+ signals rather than to global changes in intracellular Ca2+. PMID:23982204

  19. Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.

    PubMed

    Wang, Qian; Leo, M Dennis; Narayanan, Damodaran; Kuruvilla, Korah P; Jaggar, Jonathan H

    2016-06-01

    Anoctamin-1 [ANO1, also known as transmembrane protein 16A (TMEM16A)] is a Ca(2+)-activated Cl(-) channel expressed in arterial myocytes that regulates membrane potential and contractility. Signaling mechanisms that control ANO1 activity in arterial myocytes are poorly understood. In cerebral artery myocytes, ANO1 channels are activated by local Ca(2+) signals generated by plasma membrane nonselective cation channels, but the molecular identity of these proteins is unclear. Arterial myocytes express several different nonselective cation channels, including multiple members of the transient receptor potential receptor (TRP) family. The goal of this study was to identify localized ion channels that control ANO1 currents in cerebral artery myocytes. Coimmunoprecipitation and immunofluorescence resonance energy transfer microscopy experiments indicate that ANO1 and canonical TRP 6 (TRPC6) channels are present in the same macromolecular complex and localize in close spatial proximity in the myocyte plasma membrane. In contrast, ANO1 is not near TRPC3, TRP melastatin 4, or inositol trisphosphate receptor 1 channels. Hyp9, a selective TRPC6 channel activator, stimulated Cl(-) currents in myocytes that were blocked by T16Ainh-A01, an ANO1 inhibitor, ANO1 knockdown using siRNA, and equimolar replacement of intracellular EGTA with BAPTA, a fast Ca(2+) chelator that abolishes local Ca(2+) signaling. Hyp9 constricted pressurized cerebral arteries, and this response was attenuated by T16Ainh-A01. In contrast, T16Ainh-A01 did not alter depolarization-induced (60 mM K(+)) vasoconstriction. These data indicate that TRPC6 channels generate a local intracellular Ca(2+) signal that activates nearby ANO1 channels in myocytes to stimulate vasoconstriction. Copyright © 2016 the American Physiological Society.

  20. Pulsational stability of the SX Phe star AE UMa

    NASA Astrophysics Data System (ADS)

    Pena, J. H.; Renteria, A.; Villarreal, C.; Pina, D. S.; Soni, A. A.; Guillen, J.; Vargas, K.; Trejo, O.

    2016-11-01

    From newly determined times of maxima of the SX Phe star AE UMa and a compilation of previous times of maxima, we were able to determine the nature of this star. With uv photometry we determined its physical parameters.

  1. PERFACT procedure to treat supralevator fistula-in-ano: A novel single stage sphincter sparing procedure

    PubMed Central

    Garg, Pankaj

    2016-01-01

    AIM: To prospectively perform the PERFACT procedure in supralevator anal fistula/abscess. METHODS: Magnetic resonance imaging was done preoperatively in all the patients. Proximal cauterization around the internal opening, emptying regularly of fistula tracts and curettage of tracts (PERFACT) was done in all patients with supralevator fistula or abscess. All types of anal fistula and/or abscess with supralevator extension, whether intersphincteric or transsphincteric, were included in the study. The internal opening along with the adjacent mucosa was electrocauterized. The resulting wound was left open to heal by secondary intention so as to heal (close) the internal opening by granulation tissue. The supralevator tract/abscess was drained and thoroughly curetted. It was regularly cleaned and kept empty in the postoperative period. The primary outcome parameter was complete fistula healing. The secondary outcome parameters were return to work and change in incontinence scores (Vaizey objective scoring system) assessed preoperatively and at 3 mo after surgery. RESULTS: Seventeen patients were prospectively enrolled and followed for a median of 13 mo (range 5-21 mo). Mean age was 41.1 ± 13.4 years, M:F - 15:2. Fourteen (82.4%) had a recurrent fistula, 8 (47.1%) had an associated abscess, 14 (82.4%) had multiple tracts and 5 (29.4%) had horseshoe fistulae. Infralevator part of fistula was intersphincteric in 4 and transsphincteric in 13 patients. Two patients were excluded. Eleven out of fifteen (73.3%) were cured and 26.7% (4/15) had a recurrence. Two patients with recurrence were reoperated on with the same procedure and one was cured. Thus, the overall healing rate was 80% (12/15). All the patients could resume normal work within 48 h of surgery. There was no deterioration in incontinence scores (Vaizey objective scoring system). This is the largest series of supralevator fistula-in-ano (SLF) published to date. CONCLUSION: PERFACT procedure is an effective single

  2. [Applicability and indications of colonoscopic screening for Crohn's disease in patients with fistula-in-ano].

    PubMed

    Chen, Xi; He, Xiaosheng; Zou, Yifeng; Lan, Ping

    2016-09-25

    To determine the indications of colonoscopic screening for Crohn's disease in patients with fistula-in-ano. Clinical data of 302 patients with perianal fistula who received colonoscopy examination from January 2010 to December 2013 in the Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University were analyzed retrospectively. Parameters for differentiating perianal Crohn's disease from nonspecific fistulae were screened by logistic regression analysis. A regression mathematical model was established for the prediction of perianal Crohn's disease. A total of 302 patients received colonoscopy examination, and Crohn's disease was found in 16 patients (CD group). Results of univariate analysis on 26 parameters of clinical manifestation, laboratory and radiological examination revealed that differences in 11 clinical parameters between the CD group and non-CD group were statistically significant(all P<0.05), including age, BMI, abdominal pain, non-specific symptoms, multiple fistula, complex anal fistula, neutrophil count, platelet count, activated partial thromboplastin time, hemoglobin concentration and serum albumin concentration. Multivariate analysis revealed that age≤40 years (OR=14.464, 95% CI: 1.143-183.053, P=0.039), BMI<24.0 kg/m(2) (OR=8.220, 95% CI:1.005-67.200, P=0.049), abdominal pain (OR=13.148, 95% CI: 1.110-155.774, P=0.041), complex anal fistula (OR=7.056, 95% CI:1.166-42.688, P=0.033) and elevated platelet count (OR=1.012, 95% CI: 1.004-1.0194, P=0.003) were independent risk factors for discovery of Crohn's disease by colonoscopy. Area under the ROC curve of the regression mathematical model based on factors mentioned above was 0.921, indicating that the model was highly predictive. The sensitivity and specificity of this model was 81.3% and 86.7% respectively when the optimal diagnostic cut-off point was established at 0.856. Parameters that predict Crohn's disease in patients with perianal fistula include age, BMI

  3. Doppler Tomography of the Dwarf Nova IY UMa During Quiescence

    NASA Astrophysics Data System (ADS)

    Rolfe, D. J.; Abbott, T. M. C.; Haswell, C. A.

    Quiescent Doppler tomography of the newly discovered deeply-eclipsing SU UMa system IY UMa reveals properties of the region where the accretion stream from the donor impacts the edge of the disc. A very strong bright spot is produced and the Keplerian disc emission in the impact region is disrupted or obscured. The differing properties of Hα, Hβ and He I emission will allow physical parameters of the converging flow region to be studied.

  4. Astronomia cultural e meio ambiente segundo uma abordagem holística

    NASA Astrophysics Data System (ADS)

    Jafelice, L. C.

    2003-08-01

    Neste trabalho ampliamos a discussão da abordagem holística para o ensino de astronomia que temos desenvolvido nos últimos anos, analisamos novos resultados e apresentamos exemplos práticos para interessados em experimentá-la. A constatação básica a orientar este enfoque é que cursos introdutórios em astronomia costumam ser excessiva e prematuramente técnicos, além de assumirem uma visão tradicional, muito estreita, do que seja educação científica, herdada da era cartesiana e positivista da ciência. Fundamentamos porque é importante que elementos de astronomia cultural ofereçam o mote e constituam o eixo norteador daqueles cursos e porque é urgente revermos a visão que temos da relação entre astronomia e meio ambiente. Um ponto central nesta abordagem é explorar formas de reativar e atualizar uma relação orgânica com o meio e excitar a consciência de nossa inevitável e profunda interdependência com ele em nível cósmico. Neste trabalho exemplificamos a possibilidade de concretização desta proposta em três diferentes situações: disciplinas de cursos de licenciatura em geografia e em física; escolas de nível fundamental; e, neste caso ainda a ser implementada, comunidades carentes. Estes casos envolvem públicos e espaços diferenciados para educação formal e não-formal. Dos casos já implementados, destacamos os resultados alcançados pelos alunos: enriquecimento cultural, aprendizagem significativa de conteúdos astronômicos tradicionais; mudanças de comportamento, incorporando contato diário com o céu; e freqüentes vivências de sentimentos empáticos que redirecionam a relação com a natureza e a consciência ecológica global. Além disto, para interessados em aplicar esta proposta, também socializamos procedimentos e cuidados para a implementação de ações alternativas consonantes com a mesma. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

  5. Fistulectomy versus fistulotomy with marsupialisation in the treatment of low fistula-in- ano: a prospective randomized controlled trial.

    PubMed

    Chalya, Phillipo L; Mabula, Joseph B

    2013-07-01

    Low fistula-in-ano has traditionally been treated with fistulectomy and fistulotomy. Recent studies have shown that marsupialisation of the fistulotomy wounds can reduce the healing time. A randomized clinical trial was conducted at Bugando Medical Centre in north-western Tanzania between January 2008 and December 2012 to compare the efficacy of fistulectomy versus fistulotomy with marsupialisation in the treatment of low fistula in ano. Patients were randomized into two groups, namely Group A (fistulectomy) and Group B (fistulotomy with marsupialisation). A total of 162 patients were enrolled in the study and randomly assigned to Group A (n = 82) and Group B (n = 80). Both groups were comparable with respect to age, sex ratio, duration of symptoms, type of fistula and radial distance of the external opening from the anal verge. The mean healing time was statistically significantly longer in group A than in group B (P = 0.002). The duration of postoperative wound discharge was statistically significantly shorter in group B than in group A (P = 0.012). There was no statistically significant difference in the mean operating time, mean operation wound size, mean postoperative pain score, rate of surgical site infection and postoperative hospital stay between the two groups (P > 0.05). None of the patients in either group had recurrence or was found to have anal incontinence. No differences in the extent of adverse effects of surgery on the physical, social and sexual lives of the patients in the two groups. We conclude that in comparison to a fistulectomy, a fistulotomy with marsupialisation results in faster wound healing and a shorter duration of wound discharge and should therefore be recommended as a standard surgical procedure in the treatment of low fistula-in-ano.

  6. Percepção astronómica de um grupo de alunos do ensino médio de uma escola da rede estadual de São Paulo

    NASA Astrophysics Data System (ADS)

    de Oliveria, E. F.; Voelzke, M. R.

    2009-03-01

    Sendo a Astronomia uma das cièncias mais antigas da humanidade, e considerando sua importáncia histórica e cultural, é de extrema releváncia que tópicos relacionados a ela sejam tratados nas escolas. Embora os Parámetros Curriculares Nacionais do Ensino Médio (PCN-EM) e as Orientaçiacute;es Complementares aos Parámetros (PCN+) apontem a importáncia de uma abordagem significativa de conceitos relacionados à Astronomia nas aulas de Física, muitos estudantes terminam o Ensino Médio (EM) sem compreender a razão de certos acontecimentos de origem celeste, ainda que estes façam parte de seu cotidiano e sejam alvos da curiosidade natural dos jovens. Da observação dessa curiosidade em alunos de uma escola pública paulista, na cidade de Suzano, surgiu o interesse em investigar os conhecimentos básicos em Astronomia dos alunos do Ensino Médio desta escola, constituindo-se este como principal objetivo desta pesquisa. Para tanto foi elaborado um questionário de múltipla escolha aplicado inicialmente a 34 alunos do primeiro ano e, posteriormente, a mais 310, distribuídos entre as très séries do Ensino Médio dos períodos matutino e noturno. Dessa forma, observou-se que 73,9% dos estudantes identificaram o Sol como sendo uma estrela, 67,1% mostraram compreender a sucessão entre dia e noite e 52,3% relacionaram o Big Bang à origem do Universo. Em contrapartida, apenas 34,5% relacionaram as estaçíes do ano à inclinação do eixo de rotação da Terra, 21,3% indicaram a influència gravitacional simultánea da Lua e do Sol como responsável pelo fenòmeno das marés, 24,5% indicaram corretamente quais são os objetos celestes mais próximos da Terra, 36,1% identificaram ano-luz como uma medida de distáncia e 34,2% reconheceram as estrelas cadentes como meteoros, evidenciando-se assim o pequeno discernimento dos estudantes quanto aos fenòmenos e termos astronòmicos do cotidiano. Além disso, foram comparadas as respostas de alun! os de diferentes s

  7. Treatment of fistula-in-ano with cyanoacrylate glue with and without prior seton placement in rats.

    PubMed

    Romero, Gustavo Tominaga; Santos, Carlos Henrique Marques Dos; Cassino, Pedro Carvalho; Odashiro, Maçanori; Seno, Gisele Zocoller; Aléssio, Gabriela Flávia

    2016-06-01

    To evaluate the efficacy of ethyl-cyanoacrylate in the treatment of fístula-in-ano in rats with and without prior seton placement. Thirty rats Wistar with fístula-in-ano produced surgically, distributed in three groups: group A (ethyl-cyanoacrylate) - treated by application of ethyl-cyanoacrylate into fístula tract; group B (seton + ethyl-cyanoacrylate) - seton placement followed by application of ethyl-cyanoacrylate into fístula tract, 30 days later; group C (control) - no treatment. After 60 days the animals were submited to euthanasia and the specimens were analyzed by pathologist. The results were analyzed by Chi-square test with significant value of p<0.05. One animal of group B died. Were found tracts fully healed: 7, 5 and 2, in groups A, B and C, respectivelly. There was a statistically significant difference between groups A and C (p=0.02). When joined all animals treated with glue (A + B) compared to group C there was also statistically significant difference (p=0.02). The use of ethyl-cyanoacrylate glue was effective in closing anal fistulae in rats. There was no advantage in the prior application of seton.

  8. Length of follow-up after fistulotomy and fistulectomy associated with endorectal advancement flap repair for fistula in ano.

    PubMed

    Ortiz, H; Marzo, M; de Miguel, M; Ciga, M A; Oteiza, F; Armendariz, P

    2008-04-01

    The length of follow-up required after surgical repair of cryptoglandular fistula in ano has not been established. This prospective study determined the follow-up time needed to establish that an anal fistula has been cured after elective fistulotomy or fistulectomy associated with endorectal advancement flap (ERAF) repair. Between January 2001 and June 2004, consecutive patients with anal fistula of cryptoglandular aetiology were included provided that they lived within the catchment area of the hospital and agreed to participate in a follow-up programme, which comprised scheduled visits every month until complete wound healing and annually thereafter. Some 206 of 219 eligible patients were evaluable; fistulotomy was performed in 115 and ERAF repair in 91. Median follow-up was 42 (range 24-65) months. Eighteen patients had recurrence of the fistula during follow-up, with a median time to relapse of 5.0 (range 1.0-11.7) months. There were no recurrences after 1 year. Recurrence of fistula in ano of cryptoglandular origin treated by means of fistulotomy or ERAF repair occurs within the first year of operation. 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

  9. Analysing the primacy of distance in the utilization of health services in the Ahafo-Ano South district, Ghana.

    PubMed

    Buor, Daniel

    2003-01-01

    Although the distance factor has been identified as key in the utilization of health services in rural areas of developing countries, it has been analysed without recourse to related factors of travel time and transport cost. Also, the influence of distance on vulnerable groups in utilization has not been an object of survey by researchers. This paper addresses the impact of distance on utilization, and how distance compares with travel time and transport cost that are related to it in the utilization of health services in the Ahafo-Ano South (rural) district in Ghana. The study, a cross-sectional survey, also identifies the position of distance among other important factors of utilization. A sample of 400, drawn through systematic random technique, was used for the survey. Data were analysed using the regression model and some graphic techniques. The main instruments used in data collection were formal (face-by-face) interview and a questionnaire. The survey finds that distance is the most important factor that influences the utilization of health services in the Ahafo-Ano South district. Other key factors are income, service cost and education. The effect of travel time on utilization reflects that of distance and utilization. Recommendations to reduce distance coverage, improve formal education and reduce poverty have been made.

  10. BZ UMa and Var Her 04: Orphan TOADS

    NASA Astrophysics Data System (ADS)

    Price, A.; Howell, S.

    2005-05-01

    Both BZ UMa and Var Her 04 are cataclysmic variable stars without a home. Neither fit easily into current classification systems so may extend the population distribution of two unique CV types: UGWZ dwarf novae and intermediate polars. New outburst photometry and archival X-Ray data shed some new light on BZ UMa's high energy state and new spectral and IR observations from Spitzer of dust around the newly discovered cataclysmic variable Var Her 04 may help find it a home as well.

  11. Uma Visão do Universo Segundo um Grupo de Alunos do Ensino Médio de São Paulo

    NASA Astrophysics Data System (ADS)

    Elias, D. S.; Araújo, M.; Amaral, L. H.; Voelzke, M. R.; Araújo, M.

    2005-08-01

    A astronomia, embora seja uma ciência popular, com inúmeras descobertas de interesse público, ainda é apresentada desconsiderando-se os aspectos históricos e científicos relacionados ao seu desenvolvimento, sendo geralmente veiculada nos meios de comunicação de maneira pouco esclarecedora e não raro com imprecisões. Neste trabalho analisou-se a concepção de um grupo de estudantes de Ensino Médio sobre conceitos de astronomia, visando identificar sua visão de mundo a respeito do Universo, envolvendo idéias sobre espaço e tempo. Para issso, foi aplicado um questionário em três escolas da grande São Paulo em um espaço amostral de 270 alunos. Constatou-se que, embora o ensino de astronomia esteja previsto nos PCNEM, os resultados obtidos na pesquisa mostram que há grande deficiência no conhecimento dos temas investigados. Nesse sentido, verificou-se que apenas 20% dos alunos eram capazes de relacionar a sucessão das semanas com as fases da lua, enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra. Por outro lado, somente 23% dos alunos tinham noções das distâncias entre os objetos celestes próximos da Terra e 56% conseguiram relacionar o Big Bang com a origem do Universo. Finalmente, constatou-se que 37% reconheciam o ano-luz como uma unidade de distância e 60% reconheciam o Sol como sendo uma estrela. Apesar de 60% dos alunos indicarem que a escola é a principal fonte para aquisição dos conhecimentos de astronomia, conclui-se que seus conceitos nessa área ainda são inadequados, havendo necessidade de ampliação e aprimoramento da abordagem desses conteúdos nos ambientes escolares.

  12. Inhibition of cell proliferation by a selective inhibitor of the Ca{sup 2+}-activated Cl{sup -} channel, Ano1

    SciTech Connect

    Mazzone, Amelia; Eisenman, Seth T.; Strege, Peter R.; Yao, Zhen; Ordog, Tamas; Gibbons, Simon J.; Farrugia, Gianrico

    2012-10-19

    Highlights: Black-Right-Pointing-Pointer T16A{sub inh}-A01 blocked Ano1 currents in HEK cells expressing Ano1. Black-Right-Pointing-Pointer T16A{sub inh}-A01 reduced proliferation in ICC primary cultures and CFPAC-1 cell line. Black-Right-Pointing-Pointer T16A{sub inh}-A01 reduced proliferation of ICC in intact smooth muscle strips. -- Abstract: Background: Ion channels play important roles in regulation of cellular proliferation. Ano1 (TMEM16A) is a Ca{sup 2+}-activated Cl{sup -} channel expressed in several tumors and cell types. In the muscle layers of the gastrointestinal tract Ano1 is selectively expressed in interstitial cells of Cajal (ICC) and appears to be required for normal gastrointestinal slow wave electrical activity. However, Ano1 is expressed in all classes of ICC, including those that do not generate slow waves suggesting that Ano1 may have other functions. Indeed, a role for Ano1 in regulating proliferation of tumors and ICC has been recently suggested. Recently, a high-throughput screen identified a small molecule, T16A{sub inh}-A01 as a specific inhibitor of Ano1. Aim: To investigate the effect of the T16A{sub inh}-A01 inhibitor on proliferation in ICC and in the Ano1-expressing human pancreatic cancer cell line CFPAC-1. Methods: Inhibition of Ano1 was demonstrated by whole cell voltage clamp recordings of currents in cells transfected with full-length human Ano1. The effect of T16A{sub inh}-A01 on ICC proliferation was examined in situ in organotypic cultures of intact mouse small intestinal smooth muscle strips and in primary cell cultures prepared from these tissues. ICC were identified by Kit immunoreactivity. Proliferating ICC and CFPAC-1 cells were identified by immunoreactivity for the nuclear antigen Ki67 or EdU incorporation, respectively. Results: T16A{sub inh}-A01 inhibited Ca{sup 2+}-activated Cl{sup -} currents by 60% at 10 {mu}M in a voltage-independent fashion. Proliferation of ICC was significantly reduced in primary cultures

  13. Meta-Analyses of Microarray Datasets Identifies ANO1 and FADD as Prognostic Markers of Head and Neck Cancer

    PubMed Central

    Reddy, Ram Bhupal; Bhat, Anupama Rajan; James, Bonney Lee; Govindan, Sindhu Valiyaveedan; Mathew, Rohit; DR, Ravindra; Hedne, Naveen; Illiayaraja, Jeyaram; Kekatpure, Vikram; Khora, Samanta S.; Hicks, Wesley; Tata, Pramila; Kuriakose, Moni A.; Suresh, Amritha

    2016-01-01

    The head and neck squamous cell carcinoma (HNSCC) transcriptome has been profiled extensively, nevertheless, identifying biomarkers that are clinically relevant and thereby with translational benefit, has been a major challenge. The objective of this study was to use a meta-analysis based approach to catalog candidate biomarkers with high potential for clinical application in HNSCC. Data from publically available microarray series (N = 20) profiled using Agilent (4X44K G4112F) and Affymetrix (HGU133A, U133A_2, U133Plus 2) platforms was downloaded and analyzed in a platform/chip-specific manner (GeneSpring software v12.5, Agilent, USA). Principal Component Analysis (PCA) and clustering analysis was carried out iteratively for segregating outliers; 140 normal and 277 tumor samples from 15 series were included in the final analysis. The analyses identified 181 differentially expressed, concordant and statistically significant genes; STRING analysis revealed interactions between 122 of them, with two major gene clusters connected by multiple nodes (MYC, FOS and HSPA4). Validation in the HNSCC-specific database (N = 528) in The Cancer Genome Atlas (TCGA) identified a panel (ECT2, ANO1, TP63, FADD, EXT1, NCBP2) that was altered in 30% of the samples. Validation in treatment naïve (Group I; N = 12) and post treatment (Group II; N = 12) patients identified 8 genes significantly associated with the disease (Area under curve>0.6). Correlation with recurrence/re-recurrence showed ANO1 had highest efficacy (sensitivity: 0.8, specificity: 0.6) to predict failure in Group I. UBE2V2, PLAC8, FADD and TTK showed high sensitivity (1.00) in Group I while UBE2V2 and CRYM were highly sensitive (>0.8) in predicting re-recurrence in Group II. Further, TCGA analysis showed that ANO1 and FADD, located at 11q13, were co-expressed at transcript level and significantly associated with overall and disease-free survival (p<0.05). The meta-analysis approach adopted in this study has identified

  14. Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna).

    PubMed

    Derakhshan, Ali Reza

    2016-06-08

    Most cases of chronic fissure do not respond to medical treatment. Razi and Ibn Sina were 2 of the best-known scientists of ancient Persia. The purpose of this study was to find out new scientific evidence in modern medicine about their recommendations, in order to find certain clues to conduct useful researches in the future. First, treatments of anal fissure mentioned by Razi and Ibn Sina were reviewed. Then, literature search was made in electronic databases including PubMed, Scopus, and Google Scholar. Management of anal fissure according to Razi's and Ibn Sina's practices is done based on 3 interventions: lifestyle modifications, drug treatments, and manual procedures. Almost all remedies suggested by Razi and Ibn Sina have shown their effects on fissure in ano via several mechanisms of action in many in vitro and in vivo studies; Still there is lack of human studies on the subject.

  15. Stability of the multiple star system ι UMa (ADS 7114)

    NASA Astrophysics Data System (ADS)

    Mel'nikov, A. V.; Orlov, V. V.; Shevchenko, I. I.

    2014-09-01

    The physical and orbital parameters of the quadruple star system ι UMa (HD 76644 = ADS 7114) were determined earlier, when it was concluded based on modeling the system's dynamics and applying theoretical stability criteria that the system was probably unstable. Here the stability of the ι UMa system is studied by calculating the Lyapunov characteristic exponents for representative sets of parameters and initial conditions. The conclusions on the system's stability (or instability) based on various stability criteria and the calculated Lyapunov exponents are compared. The instability of the system as a whole is confirmed rigorously based on massive computations of the Lyapunov exponents. This system appears to be the only known multiple system whose instability has been rigorously established. The Lyapunov time-disruption time statistical relations are constructed, which show that the Hamiltonian intermittency of the second kind dominates. Typical disruption times are shorter than 1000 years, and the Lyapunov times are shorter than 100 years.

  16. Electronic structure and spectroscopic properties of mixed sodium actinide oxides Na2AnO4 (An = U, Np, Pu, Am)

    NASA Astrophysics Data System (ADS)

    Kovács, Attila

    2017-03-01

    Multireference relativistic post-HF and DFT calculations have been performed on four Na2AnO4 (An = U, Np, Pu, Am) molecules. Beyond the electronic characteristics of the ground and excited electronic states, the molecular geometries and vibrational frequencies have been determined.

  17. AB310. SPR-37 Cholinergic excitatory motor responses in the colon are mediated through the calcium-activated chloride conductance Ano1

    PubMed Central

    Hwang, Sung Jin; Blair, Peter J.; Rock, Jason; Pardo, David; Sanders, Kenton M.; Ward, Sean M.

    2016-01-01

    Objective There is a growing body of evidence that gastrointestinal smooth muscle excitability is regulated by several different classes of interstitial cells [interstitial cells of Cajal (ICC) and PDGFRα(+) cells] that are electrically coupled to SMC. Thus, ‘myogenic’ activity results from the integrated behavior of the SMC/ICC/PDGFRα(+) cell (SIP) syncytium. Inputs from excitatory and inhibitory motor neurons are required to produce the complex motor patterns of the gut and coordinate GI motility. Motor neurons innervate these three cell types in the SIP syncytium, and receptors, second messenger pathways, and ion channels in these cells mediate postjunctional responses. Cholinergic neurotransmission in GI muscles from several species has long been thought to be dependent upon activation of a non-selective cation conductance in smooth muscle cells and the molecular candidates for mediating cholinergic excitation have been reported to be the transient receptor protein channels Trpc4 and Trpc6. However, we have shown that cholinergic responses in the GI tract involve ICC and in their absence these motor responses are greatly diminished or absent. We sought to determine the conductance(s) responsible for cholinergic motor responses in the colon. Methods Cre-LoxP recombinase technology was utilized to determine the role of the calcium-activated chloride conductance, Ano1 in post-junctional motor responses in the mouse colon in a cell-specific manner (Kit+ ICC). c-KitCreERT2/+ (Kit-Cre) mice and Ano f/f mice were crossed to generate c-KitCreERT2/+; Ano1f/f (mutants) and c-KitCreERT2/+; Ano1f/+ (controls) animals that were subsequently treated with tamoxifen to induce Cre recombinase expression in ICC. Confocal microscopy was used to determine the cell type Cre expression was switched on. Intracellular microelectrode recordings were performed to determine changes in post-junctional neural responses to nerve stimulation in c-KitCreERT2/+ (Kit-Cre) mice and Anof

  18. Estrogens Exacerbate Nociceptive Pain via Up-Regulation of TRPV1 and ANO1 in Trigeminal Primary Neurons of Female Rats.

    PubMed

    Yamagata, Kazuaki; Sugimura, Mitsutaka; Yoshida, Miki; Sekine, Shinichi; Kawano, Akiyo; Oyamaguchi, Aiko; Maegawa, Hiroharu; Niwa, Hitoshi

    2016-11-01

    Several trigeminal pain disorders show sex differences, and high levels of estrogens may underlie these differences. The interaction between transient receptor potential vanilloid 1 (TRPV1) and anoctamin 1 (ANO1) plays an important role in peripheral nociception. However, whether TRPV1 and ANO1 are involved in estrogen-modulated trigeminal pain sensitivity is unclear. In this study, we examined estradiol (E2) modulation of nociception through behavioral and immunohistological experiments after application of capsaicin (Cap), a selective TRPV1 agonist, onto the ocular surface in ovariectomized rats treated with high-dose E2 (HE) or low-dose E2 (LE) for 2 days. In addition, we used real-time PCR to study the effects of E2 on the expression levels of TRPV1 and ANO1 mRNA in trigeminal ganglia. In the behavioral experiment, the HE group showed significant potentiation of Cap-evoked nocifensive behavior compared with the LE group. Immunohistochemistry showed that Cap evoked a significantly greater number of cells that were immunoreactive for c-Fos, a marker of nociceptive activation, in the trigeminal subnucleus caudalis/upper cervical cord in the HE group than in the LE group. The number of c-Fos-immunoreactive cells in the ventral trigeminal interpolaris/caudalis were similar in the 2 groups. Real-time PCR showed that the levels of TRPV1 and ANO1 mRNA in the HE group were significantly higher than levels in the LE group. Thus, high levels of estrogens may be a risk factor for Cap-evoked nociceptive pain, and estrogen-dependent increases in TRPV1 and ANO1 are likely involved in modulating the nociceptive response in the trigeminal area.

  19. Revisiting an ancient treatment for transphincteric fistula-in-ano ‘There is nothing new under the sun’ Ecclesiastes 1v9

    PubMed Central

    Sturgeon, G; Hargest, R

    2015-01-01

    Objective The history of treatments for fistula-in-ano can be traced back to ancient times. Current treatment of transphincteric fistulae is controversial, with many options available. We reviewed the history of treatment using cutting setons and present our series of transphincteric fistulae in the light of the series in the literature. Design Literature review and case series. Setting Hospital based coloproctology service Participants 140 consecutive patients presenting with fistula-in-ano were included. Main Outcome Measures The literature pertaining to treatment of transphincteric fistula was reviewed, along with the outcome of various treatment methods for this condition. Data were collected for 140 consecutive patients presenting with fistula- in-ano were assessed for fistula healing, recurrence and complications. Results A total of 140 consecutive patients with fistula-in-ano were identified, of which 111 were cryptoglandular (79.3%). Eighty-one of these 111 were transphincteric (73.0%). At a median follow-up of 35 months (range, 2–83 months), 70 transphincteric fistulae had healed (86.4%), 10 were still undergoing treatment (12.3%) and one patient was lost to follow-up prior to treatment (1.2%). Two patients in this group required a stoma (2.5%), six patients developed recurrence (7.4%); three ‘true’ recurrences (3.7%). One (1.2%) developed a chronic fissure. There were no reported cases of incontinence. Conclusions The management of transphincteric fistula-in-ano is complex and controversial, for which no clear surgical procedure has gained acceptance as the gold standard. This study demonstrates that transphincteric fistulae can be successfully treated using cutting setons. A high healing rate (86.4%), low recurrence rate (7.4%) and a low complication rate (3.7%) are shown, which compares favourably with published rates over a long follow-up. PMID:26152674

  20. Uso de modelos mecânicos em curso informal de astronomia para deficientes visuais. Resgate de uma experiência

    NASA Astrophysics Data System (ADS)

    Tavares, E. T., Jr.; Klafke, J. C.

    2003-08-01

    O presente trabalho propõe-se a resgatar uma experiência que teve lugar no Planetário de São Paulo nos anos 60. Em 1962, o Sr. Acácio, então com 37 anos, deficiente visual desde os 27, passou a assistir às aulas ministradas pelo Prof. Aristóteles Orsini aos integrantes do corpo de servidores do Planetário. O Sr. Acácio era o único deficiente da turma e, embora possuísse conhecimentos básicos e relativamente avançados de matemática, enfrentava dificuldades na compreensão e acompanhamento da exposição, como também em estudos posteriores. Com o intuito de auxiliá-lo na superação desses problemas, o Prof. Orsini solicitou a construção de modelos mecânicos que, através do sentido do tato, permitissem o acompanhamento das aulas e a transposição do modelo para o "constructo" mental. Essa prática mostrou-se tão eficaz que facilitou sobejamente o aprendizado da matéria pelo sujeito. O Sr. Acácio passou a integrar o corpo de professores do Planetário/Escola Municipal de Astrofísica, tendo ficado responsável pelo curso de "Introdução à Astronomia" por vários anos. Além disso, a experiência foi tão bem sucedida que alguns dos modelos tiveram seus elementos constitutivos pintados diferencialmente para serem utilizados em cursos regulares do Planetário, tornando-se parte integrante do conjunto de recursos didáticos da instituição. É pensando nessa eficácia, tanto em seu objetivo original permitir o aprendizado de um deficiente visual quanto no subsidiário recurso didático sistemático da instituição que decidimos resgatar essa experiência. Estribados nela, acreditamos ser extremamente produtivo, em termos educacionais, o aperfeiçoamento dos modelos originais, agora resgatados e restaurados, e a criação de outros que pudessem ser utilizados no ensino dessa ciência a deficientes visuais.

  1. A comparative clinical study of Snuhi Ksheera Sutra, Tilanala Kshara Sutra and Apamarga Kshara Sutra in Bhagandara (Fistula in Ano)

    PubMed Central

    Lobo, Supreeth Joyal; Bhuyan, C.; Gupta, S. K.; Dudhamal, T. S.

    2012-01-01

    Bhagandara (Fistula in Ano) at modern parlance is a common anorectal condition prevalent in the populations worldwide and its prevalence is second highest after Arsha (hemorrhoids). Kshara Sutra (K.S.) is one of the chief modality in the treatment of Bhagandara in Ayurvedic science. Exploration of the new plants for the preparation of Kshara as a better substitute to Apamarga Kshara is the need of the hour. To find out an effective alternative to Apamarga K.S. in view of easy processing, a Snuhi Ksheera Sutra without any Kshara and the Tilanala K.S. were opted for their clinical evaluation. Total 33 cases of Bhagandara were divided randomly into 3 groups, having 11 patients in each group. In Group A, Snuhi Ksheera Sutra; in Group B, Tilanala K.S. and in Group C, Apamarga K.S. were used. Assessment was done on objective (Unit Cutting Time - UCT) and subjective parameters. Statistically insignificant difference was observed in the efficacy of treatment by subjective parameters like pain, discharge, etc. between the three groups. It was found that Tilanala K.S. showed higher UCT (9.76 days) while lower in Snuhi Ksheera Sutra (7.42 days) as compared to Apamarga K.S. (8.82 days). Thus Tilanala K.S. can be used as a substitute for Apamarga K.S. and Snuhi Ksheera Sutra can be employed in the recurrent fibrosed cases of Bhagandara. PMID:23049190

  2. MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology.

    PubMed

    Sonneville, Florence; Ruffin, Manon; Coraux, Christelle; Rousselet, Nathalie; Le Rouzic, Philippe; Blouquit-Laye, Sabine; Corvol, Harriet; Tabary, Olivier

    2017-09-27

    Cystic fibrosis results from reduced cystic fibrosis transmembrane conductance regulator protein activity leading to defective epithelial ion transport. Ca(2+)-activated Cl(-) channels mediate physiological functions independently of cystic fibrosis transmembrane conductance regulator. Anoctamin 1 (ANO1/TMEM16A) was identified as the major Ca(2+)-activated Cl(-) channel in airway epithelial cells, and we recently demonstrated that downregulation of the anoctamin 1 channel in cystic fibrosis patients contributes to disease severity via an unknown mechanism. Here we show that microRNA-9 (miR-9) contributes to cystic fibrosis and downregulates anoctamin 1 by directly targeting its 3'UTR. We present a potential therapy based on blockage of miR-9 binding to the 3'UTR by using a microRNA target site blocker to increase anoctamin 1 activity and thus compensate for the cystic fibrosis transmembrane conductance regulator deficiency. The target site blocker is tested in in vitro and in mouse models of cystic fibrosis, and could be considered as an alternative strategy to treat cystic fibrosis.Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse models.

  3. Evolutionary scenario for W UMa-type stars

    NASA Astrophysics Data System (ADS)

    Stepień, K.; Gazeas, K.

    2008-10-01

    An alternative to TRO model of a W UMa-type star is presented in which the binary is past mass exchange with mass ratio reversal. The secondary is hydrogen depleted and both components are in thermal equilibrium. Evolution in contact is driven by orbital angular momentum loss and mass transfer from the secondary to primary component, similarly as it is observed in Algols. Temperature equalization of both components results from an assumed energy transfer by a large scale flow encircling the whole system in the common envelope.

  4. STT Doubles with Large DM - Part II: Leo and UMa

    NASA Astrophysics Data System (ADS)

    Knapp, Wilfried; Nanson, John; Smith, Steven

    2016-02-01

    The results of visual double star observing sessions suggested a pattern for STT doubles with large DM being harder to resolve than would be expected based on the WDS catalog data. It was felt this might be a problem with expectations on one hand, and on the other might be an indication of a need for new precise measurements, so we decided to take a closer look at a selected sample of STT doubles and do some research. We found that also in Leo and Uma at least several of the selected objects show parameters quite different from the current WDS data.

  5. V4641 Sgr and KV UMa. Two black hole candidates

    NASA Astrophysics Data System (ADS)

    Chuprikov, A.; Guirin, I.

    We have analized the results of processing of the NRAO archive VLA and VLBA data for two star objects titled V4641 Sgr (J1819-2524) and KV UMa (X1118+4802). Some radio images of both sources for some frequency ranges are presented. Data have been processed with the software project titled 'Astro Space Locator' (ASL for Windows). The Multi Frequency Synthesis (MFS) method has been used for reconstruction of radio maps. Images of both sources are presented. Any polarization phenomena are not taken into account. We present results of processing of data of RR polarization for all the observational sessions.

  6. Comparing existing classifications of fistula-in-ano in 440 operated patients: Is it time for a new classification? A Retrospective Cohort Study.

    PubMed

    Garg, Pankaj

    2017-06-01

    Fistula-in-ano are classified so as to grade them according to increasing complexity which can help guide their management. The classifications used are Parks, St James Hospital University (SJHU) and Standard Practice Task Force (SPTF). Laying open (fistulotomy) of the fistula tract is the most commonly done procedure for fistula-in-ano and has high success rate. The lower grade fistulas are supposed to have low risk of incontinence when laid open and vice-versa. The objective of the study was to evaluate the efficacy of the existing classifications. 440 consecutive fistula-in-ano patients operated over four years were analyzed on the basis of preoperative MRI scan and operative findings. It was assessed whether the amenability to fistulotomy (measurement of fistula simplicity) correlated with the fistula-in-ano grades in different classifications. Out of 440 patients operated, 242 underwent fistulotomy whereas 198 underwent sphincter-sparing procedures for complex fistula. As per SJHU classification, the amenability to fistulotomy was 99.1% in Grade-I, 82.1% in Grade-II, 46.2% in Grade-III, 29.0% in Grade-IV and 5.4% in Grade-V. In Park's classification, the amenability to fistulotomy was 93.5% in Grade-I, 34.8% in Grade-II, 5.4% in Grade-III and 0% in Grade-IV. As per SPTF classification, 99.3% of simple and 32.1% of complex fistulas underwent fistulotomy. Even the higher grade fistula-in-ano in all three classifications had high rate of amenability to fistulotomy. Therefore none of the above classifications were accurate. A new classification is being proposed which divides fistula-in-ano in 5 grades in order of increasing complexity. Grade I & II are simple fistulas (fistulotomy be done conveniently) and Grade III-V are high complex fistulas (fistulotomy should not be attempted). The data was analyzed as per new classification and found it to be highly accurate. None of the existing classifications accurately correlated between the grade and the complexity of

  7. Anal fistula plug vs mucosa advancement flap in complex fistula-in-ano: A meta-analysis

    PubMed Central

    Leng, Qiang; Jin, Hei-Ying

    2012-01-01

    AIM: To investigate the efficacy of the anal fistula plug (AFP) compared to the mucosa advancement flap (MAF), considered the best procedure for patients with a complex anal fistula. METHODS: The literature search included PubMed, EMBASE, Cochrane Library and OVID original studies on the topic of AFP compared to MAF for complex fistula-in-ano that had a deadline for publication by April 2011. Randomized controlled trials, controlled clinical trials and prospective cohort studies were included in the review. After information collection, a meta-analysis was performed using data on overall success rates as well as incidence of incontinence and morbidity. The quality of postoperative life was also included with the clinical results. RESULTS: Six studies involving 408 patients (AFP = 167, MAF = 241) were included in the meta-analysis. The differences in the overall success rates and incidence of fistula recurrence were not statistically significant between the AFP and MAF [risk difference (RD) = -0.12, 95%CI: -0.39 - 0.14; RD = 0.13; 95%CI: -0.18 - 0.43, respectively]. However, for the AFP, the risk of postoperative impaired continence was lower (RD = -0.08, 95%CI: -0.15 - -0.02) as was the incidence of other complications (RD = -0.06, 95%CI: -0.11 - -0.00). The postoperative quality of life, for patients treated using the AFP was superior to that of the MAF patients. Patients treated with the AFP had less persistent pain of a shorter duration and the healing time of the fistula and hospital stay were also reduced. CONCLUSION: The AFP is an effective procedure for patients with a complex anal fistula; it has the same success rate but a lower risk of complications than the MAF and may also be associated with an improved postoperative quality of life. Additional evidence is needed to confirm these findings. PMID:23494149

  8. Unraveling the Mysteries of Océano Profundo: New organisms, ecosystems and geohazards in deep water around Puerto Rico

    NASA Astrophysics Data System (ADS)

    Cantwell, K. L.; Kennedy, B. R.; Quattrini, A.; Cheadle, M. J.; Sowers, D.; Lobecker, E.; Ford, M.; Garcia-Moliner, G.; Gray, L. M.; Chaytor, J. D.; Demopoulos, A. W.

    2016-02-01

    From February to April 2015, NOAA Ship Okeanos Explorer, America's Ship for Ocean Exploration, surveyed unknown deep-sea ecosystems and potential geohazards off the coast of Puerto Rico and the US Virgin Islands. Over 37,500 km² of high-resolution multibeam sonar data was collected, revealing rugged canyons along shelf breaks, intricate incised channels, and large slumps and slope failures. Twelve remotely operated vehicle (ROV) dives, surveyed seamounts, escarpments, and submarine canyons at depths of 300-6,000 m. Additional ROV exploration of the water column occurred at depths of 800-1200 m. Dives included three of the deepest dives ever conducted in the Puerto Rico Trench and the first exploration of Exocet and Whiting seamounts. Discoveries included assemblages of deep-sea corals (>50 species), and observations of several rare and new species. For example, the seastar Laetmaster spectabilis had not been documented since its original description in 1881 and a new species of benthopelagic cydippid ctenophore was observed at 3900 m in the Aricebo Amphitheater. Other expedition highlights included two rarely observed blind octopods (Cirrothauma murrayi); novel observation of a symbiotic association between predatory tunicates with polychaete associates; and approximately 75 species of demersal fishes, including a new species of wrasse and the first records of Shaefer's anglerfish and the ateleopodid jellynose in Puerto Rican waters. ROV dives traversed elements of the complete geological succession from 1 km deep into the Cretaceous volcanic arc basement, across the carbonate platform sequence unconformity and into the uppermost Pliocene carbonates. Highlights included spectacular slope failure headwall scarps and sub-aerial karstic weathering of the youngest carbonates. All data collected during Océano Profundo 2015 are now publicly available through the National Archives and are awaiting further analysis by the scientific community.

  9. Treatment of transsphincteric fistula-in-ano with growth factors from autologous platelets: results of a phase II clinical trial.

    PubMed

    de la Portilla, F; Segura-Sampedro, J J; Reyes-Díaz, M L; Maestre, M V; Cabrera, A M; Jimenez-Rodríguez, R M; Vázquez-Monchul, J M; Diaz-Pavón, J M; Padillo-Ruiz, F J

    2017-07-29

    The aim of this paper is to evaluate to the safety, feasibility and efficacy of a novel treatment for transsphincteric cryptoglandular fistula: injection of autologous plasma rich in growth factors (PRGF) into the fistula tract accompanied by sealing using a fibrin plug created from the activated platelet-poor fraction of the same plasma. This article is a prospective, phase II clinical trial. The procedure was externally audited. Thirty-six patients diagnosed with transsphincteric fistula-in-ano were included. All patients underwent follow-up examinations at 1 week and again at 3, 6 and 12 months after discharge. Main outcome measures safety (number of adverse events), feasibility and effectiveness of the treatment. A total of 36 patients received the study treatment, with the procedure found to be feasible in all patients. A total of seven adverse events (AE) related to the injected product or surgical procedure were identified in 4 of 36 patients. At the end of the follow-up period (12 months), 33.3% of patients (12/36) had achieved complete fistula healing and 11.1% of patients (4/36) had achieved partial healing. In total, this amounted to 44.4% of patients (16/36) being asymptomatic at final follow-up. In successfully healed patients, a gradual reduction in pain was observed, as measured using a Visual Analog Scale (VAS) (p = 0.0278). Compared to baseline, a significant improvement in Wexner score was seen in patients achieving total or partial healing of the fistula (p = 0.0195). The study treatment was safe and feasible, with apparently modest efficacy rates. Continence and pain improvement following treatment may be considered predictive factors for healing.

  10. X-ray sterilization of the An. arabiensis genetic sexing strain 'ANO IPCL1' at pupal and adult stages.

    PubMed

    Ndo, C; Yamada, H; Damiens, D D; N'do, S; Seballos, G; Gilles, J R L

    2014-03-01

    With a view to area wide integrated pest management programs with a sterile insect technique (SIT) component against the malaria vector Anopheles arabiensis, the effects of X-ray exposure of males of the genetic sexing strain (GSS) of An. arabiensis, "ANO IPCL1" have been tested. The suitability of X-ray was assessed in comparison to gamma-ray for mosquito sterilization in operational settings where the acquisition of gamma ray irradiators may be problematic. Pupae and adult males were sterilized using X-ray irradiation at 5 increasing doses and effects were observed in terms of fecundity and fertility. Irradiated pupae and adults were further observed for effects on longevity. The adult stage appeared to be more sensitive to radiation exposure than the pupal stage, with a residual fertility of 1% in adults irradiated at 75Gy and 0% at 105Gy, compared to 8%at 75Gy and 4% at 105Gy in adults irradiated at the pupal stage. All treatment groups except those irradiated at 60Gy were statistically different from the control groups in terms of adult longevity post treatment, however overall survival was not highly compromised in the 75Gy treatment group which showed 96% of induced sterility. To ensure the fine balance between the induced sterility and the fitness of the insect produced is achieved, irradiation of adults at this dose may be a good compromise for the SIT as applied for this species, especially in specific cases such as sterilization after female elimination by spiking blood meals. Investigation into the combined effects of blood spiking and irradiation at the adult stage and additional competitiveness studies both in laboratory and field cages will provide more insight into the radiation dose and mosquito stage to be used in the frame of future SIT programs targeting this important malaria vector.

  11. Cyclic Period Oscillation of the Eclipsing Dwarf Nova DV UMa

    NASA Astrophysics Data System (ADS)

    Han, Z.-T.; Qian, S.-B.; Irina, Voloshina; Zhu, L.-Y.

    2017-05-01

    DV UMa is an eclipsing dwarf nova with an orbital period of ˜2.06 hr, which lies just at the bottom edge of the period gap. To detect its orbital period changes, we present 12 new mid-eclipse times by using our CCD photometric data and archival data. The latest version of the O-C diagram, combined with the published mid-eclipse times in quiescence, and spanning ˜30 years, was obtained and analyzed. The best fit to those available eclipse timings shows that the orbital period of DV UMa is undergoing a cyclic oscillation with a period of 17.58(+/- 0.52) years and an amplitude of 71.1(+/- 6.7) s. The periodic variation most likely arises from the light-travel-time effect via the presence of a circumbinary object, because the required energy to drive the Applegate mechanism is too high in this system. The mass of the unseen companion was derived as {M}3\\sin i\\prime =0.025(+/- 0.004) {M}⊙ . If the third body is in the orbital plane (i.e., i\\prime =i=82\\buildrel{\\circ}\\over{.} 9) of the eclipsing pair, this would indicate it is a brown dwarf. This hypothetical brown dwarf is orbiting its host star at a separation of ˜8.6 au in an eccentric orbit (e = 0.44).

  12. Microscopic theory of the insulating electronic ground states of the actinide dioxides AnO2 (An = U, Np, Pu, Am, and Cm)

    NASA Astrophysics Data System (ADS)

    Suzuki, M.-T.; Magnani, N.; Oppeneer, P. M.

    2013-11-01

    The electronic states of the actinide dioxides AnO2 (with An = U, Np, Pu, Am, and Cm) are investigated employing first-principles calculations within the framework of the local density approximation +U (LDA+U) approach, implemented in a full-potential linearized augmented plane-wave scheme. A systematic analysis of the An-5f states is performed which provides intuitive connections between the electronic structures and the local crystalline fields of the f states in the AnO2 series. Particularly the mechanisms leading to the experimentally observed insulating ground states are investigated. These are found to be caused by the strong spin-orbit and Coulomb interactions of the 5f orbitals; however, as a result of the different configurations, this mechanism works in distinctly different ways for each of the AnO2 compounds. In agreement with experimental observations, the nonmagnetic states of plutonium and curium dioxide are computed to be insulating, whereas those of uranium, neptunium, and americium dioxides require additional symmetry breaking to reproduce the insulator ground states, a condition which is met with magnetic phase transitions. We show that the occupancy of the An-f orbitals is closely connected to each of the appearing insulating mechanisms. We furthermore investigate the detailed constitution of the noncollinear multipolar moments for transverse 3q magnetic ordered states in UO2 and longitudinal 3q high-rank multipolar ordered states in NpO2 and AmO2.

  13. Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

    PubMed Central

    Xiao, Qinghuan; Yu, Kuai; Perez-Cornejo, Patricia; Cui, Yuanyuan; Arreola, Jorge; Hartzell, H. Criss

    2011-01-01

    Ca2+-activated Cl− channels (CaCCs) are exceptionally well adapted to subserve diverse physiological roles, from epithelial fluid transport to sensory transduction, because their gating is cooperatively controlled by the interplay between ionotropic and metabotropic signals. A molecular understanding of the dual regulation of CaCCs by voltage and Ca2+ has recently become possible with the discovery that Ano1 (TMEM16a) is an essential subunit of CaCCs. Ano1 can be gated by Ca2+ or by voltage in the absence of Ca2+, but Ca2+- and voltage-dependent gating are very closely coupled. Here we identify a region in the first intracellular loop that is crucial for both Ca2+ and voltage sensing. Deleting 448EAVK in the first intracellular loop dramatically decreases apparent Ca2+ affinity. In contrast, mutating the adjacent amino acids 444EEEE abolishes intrinsic voltage dependence without altering the apparent Ca2+affinity. Voltage-dependent gating of Ano1 measured in the presence of intracellular Ca2+ was facilitated by anions with high permeability or by an increase in [Cl−]e. Our data show that the transition between closed and open states is governed by Ca2+ in a voltage-dependent manner and suggest that anions allosterically modulate Ca2+-binding affinity. This mechanism provides a unified explanation of CaCC channel gating by voltage and ligand that has long been enigmatic. PMID:21555582

  14. A novel ANO3 variant identified in a 53-year-old woman presenting with hyperkinetic dysarthria, blepharospasm, hyperkinesias, and complex motor tics.

    PubMed

    Blackburn, Patrick R; Zimmermann, Michael T; Gass, Jennifer M; Harris, Kimberly G; Cousin, Margot A; Boczek, Nicole J; Ross, Owen A; Klee, Eric W; Brazis, Paul W; Van Gerpen, Jay A; Atwal, Paldeep S

    2016-12-05

    Cervical dystonias have a variable presentation and underlying etiology, but collectively represent the most common form of focal dystonia. There are a number of known genetic forms of dystonia (DYT1-27); however the heterogeneity of disease presentation does not always make it easy to categorize the disease by phenotype-genotype comparison. In this report, we describe a 53-year-old female who presented initially with hand tremor following a total hip arthroplasty. The patient developed a mixed hyperkinetic disorder consisting of chorea, dystonia affecting the upper extremities, dysarthria, and blepharospasm. Whole exome sequencing of the patient revealed a novel heterozygous missense variant (Chr11(GRCh38): g.26525644C > G; NM_031418.2(ANO3): c.702C > G; NP_113606.2. p.C234W) in exon 7 in the ANO3 gene. ANO3 encodes anoctamin-3, a Ca(+2)-dependent phospholipid scramblase expressed in striatal-neurons, that has been implicated in autosomal dominant craniocervical dystonia (Dystonia-24, DYT24, MIM# 615034). To date, only a handful of cases of DYT-24 have been described in the literature. The complex clinical presentation of the patient described includes hyperkinesias, complex motor movements, and vocal tics, which have not been reported in other patients with DYT24. This report highlights the utility of using clinical whole exome sequencing in patients with complex neurological phenotypes that would not normally fit a classical presentation of a defined genetic disease.

  15. Multi-informant assessment of anxiety regarding ano-genital examinations for suspected child sexual abuse (CSA).

    PubMed

    Scribano, Philip V; Hornor, Gail; Rhoda, Dale; Curran, Sherry; Stevens, Jack

    2010-08-01

    Given the commonly held belief that physical examinations for child sexual abuse (CSA) are very distressing, our primary objective was to evaluate anxiety during these assessments using the Multidimensional Anxiety Score for Children (MASC-10). A second objective was to compare self-reported anxiety to parental report using the MASC-10 and to medical provider's rating of emotional distress using the Genital Examination Distress Scale (GEDS). Child/parent dyads completed the MASC-10 prior to the evaluation and were retested at the completion of the medical exam. GEDS assessment occurred during the medical exam. One hundred seventy-five subject dyads were enrolled and were predominantly female (77%), Caucasian (66%), accompanied by mother (90%), and receiving Medicaid (57%). A significant subgroup of children reported clinically significant levels of anxiety at the pre-examination assessment (17.1%) and post-examination assessment (15.4%). However, most subjects reported low anxiety at both pre- and post-examination assessments. Both child and parent report demonstrated less anxiety, on average, post-examination compared to pre-examination scores. Reduced anxiety was measured with a mean pre-T-score=55.8 versus mean post-T-score=53.1 (p<.001). Correlation coefficients for pre-T-scores and post-T-scores of child/parent dyad were 0.3257 (p<.0001) and 0.3403 (p<.0001). A small correlation was noted between child reported anxiety and medical provider observation using the GEDS for pre-exam (0.1904, p=.01), and post-exam (0.2090, p=.02). Our research indicates that the majority of children are not severely anxious during medical evaluations for CSA. In addition, the MASC-10 shows promise as an instrument to assess anxiety from the ano-genital examination in CSA because it could be quickly completed by most patients and their parents, indicated a wide range of anxiety levels, and demonstrated some sensitivity to change. While parent report may identify some child anxiety

  16. Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms.

    PubMed

    Scudieri, Paolo; Caci, Emanuela; Venturini, Arianna; Sondo, Elvira; Pianigiani, Giulia; Marchetti, Carla; Ravazzolo, Roberto; Pagani, Franco; Galietta, Luis J V

    2015-09-01

    TMEM16F is a membrane protein with possible dual function as an ion channel and a phospholipid scramblase. The properties of ion channels associated with TMEM16F and the link between ion channel and scramblase activity are a matter of debate. We studied the properties of four isoforms of TMEM16F generated by alternative splicing. Upregulation of three TMEM16F isoforms or silencing of endogenous TMEM16F increased and decreased, respectively, both scramblase and channel activities. Introduction of an activating mutation in TMEM16F sequence caused a marked increase in phosphatidylserine scrambling and in ion transport indicating direct involvement of the protein in both functions. TMEM16F, also known as ANO6, is a membrane protein that has been associated with phospholipid scramblase and ion channel activity. However, the characteristics of TMEM16F-dependent channels, particularly the ion selectivity, are a matter of debate. Furthermore, the direct involvement of TMEM16F in phospholipid scrambling has been questioned. We studied the properties of different TMEM16F variants generated by alternative splicing. Using whole-cell patch-clamp recordings, we found that V1, V2 and V5 variants generated membrane currents activated by very high (micromolar) intracellular Ca(2+) concentrations and positive membrane potentials. These variants showed different degrees of Ca(2+) sensitivity and kinetics of activation but similar ion permeability, characterized by a slight selectivity for Cl(-) over Na(+) . A fourth variant (V3) showing a unique carboxy-terminus was devoid of activity, in agreement with its intracellular localization. We also measured scramblase activity using the binding of annexin V to detect phosphatidylserine on the cell surface. V1, V2 and V5 variants were associated with calcium-dependent phosphatidylserine externalization. Interestingly, introduction of an activating mutation, D409G, produced a marked increase in the apparent Ca(2+) sensitivity of TMEM16F

  17. Recent developments on SU UMa stars - theory vs. observation

    NASA Astrophysics Data System (ADS)

    Cannizzo, John K.

    2015-01-01

    Kepler light curves of short period dwarf novae have resparked interest in the nature of superoutbursts and led to the question: Is the thermal-tidal instability needed, or can the plain vanilla version of the accretion disk limit cycle do the job all by itself? A detailed time-resolved study of an eclipsing SU UMa system during superoutburst onset should settle the question - if there is a dramatic contraction of the disk at superoutburst onset, Osaki's thermal-tidal model would be preferred; if not, the plain disk instability model would be sufficient. I will present recent results that support the contention by Osaki & Kato that the time varying negative superhump frequencies can be taken as a surrogate for the outer disk radius variations. Finally, it may be necessaryto look beyond the short period dwarf novae to gain perspective on the nature of embedded precursors in long outbursts.

  18. The accretion process in AR UMa, an extremely magnetized polar

    NASA Astrophysics Data System (ADS)

    Scipione, Valentina

    2012-10-01

    We propose a triggered observation of the highest magnetized polar, AR UMa. Our target with a magnetic field of about 230 MG gives access to an unexplored parameter regime. It escaped XMM-Newton so far due to extended low states. Utilizing the broad spectral range covered by XMM-Newton including the OM, we will simultaneously determine the energy content of the three cooling channels of the post-shock accretion plasma: cyclotron radiation in the UV, plasma radiation in hard X-rays and re-processed radiation in soft X-rays. We will confront our observations with state-of-art models and study quantitatively the energy balance of the cooling plasma as a function of the accretion rate and the magnetic field strength.

  19. Origin and evolution of contact binaries of W UMa type

    NASA Astrophysics Data System (ADS)

    Rahunen, T.; Vilhu, O.

    Angular momentum loss estimates for single stars are employed to discuss three theories for contact binary evolution. Two of the theories of the metamorphoses of W UMa stars involve the fission of a rapidly rotating star at the end of the pre-main sequence contraction phase, resulting in a constant level of angular momentum and small mass ratios. The second sequence comprises an evolution of the companion from angular momentum loss from a detached or semidetached binary. Chromospheric Ca(+) emission observations are noted to correlate with rotational velocity predicted for the second type of evolution of angular momentum loss rate. The models display cyclic behavior on a time scale of one to ten million years, although the contact never breaks. It is concluded that the constant angular momentum models require a formation process which yield unequal components, while the detached, followed by contact, process is the most natural production mechanism.

  20. Video-Assisted Anal Fistula Treatment (VAAFT) in Cryptoglandular fistula-in-ano: A systematic review and proportional meta-analysis.

    PubMed

    Garg, Pankaj; Singh, Pratiksha

    2017-09-04

    Video-Assisted Anal Fistula Treatment (VAAFT) is a relatively new minimally invasive videoendoscopic procedure for treating fistula-in-ano. We reviewed and performed metaanalysis to evaluate the efficacy of this procedure. Studies from the period 2010 to 2016 were searched in PubMed, Medline, Scopus, Embase, Ovid, SCI database, Cochrane Central Register of Controlled Trials (CENTRAL) & Google Scholar database. All studies which utilized VAAFT to treat fistula-in-ano were extracted. The studies in which the Cryptoglandular fistula were treated were included. Procedure's done in patients with Crohn's disease, pediatric patients and associated malignancy were excluded from the study. The primary outcome parameter was success rate in fistula healing and the secondary outcome parameters were operating time, hospital stay, return to work, incontinence rate and complication rate. A total of 1378 studies were screened. Out of these, eight studies were finally included for meta-analysis. The analysis (n = 786) demonstrated a net Proportion Meta-analysis pooled rate of 76.01% (95% CI = 68.1 to 83.9) for success rate, 16.2% (95% CI = 12.1 to 20.2) for complications, 44.7 min (95% CI = 38.3 to 51.2) for operating time, 1-4.1 days for mean hospital stay and 1-11 days for return to work. None of the studies reported worsening of continence levels. VAAFT is a safe videoendoscopic method to treat fistula-in-ano with an overall success rate of 76% (net Proportion Meta-analysis pooled rate). The main benefit of the procedure is minimal risk to incontinence, minimal hospital stay and early return to work. Copyright © 2017 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

  1. Surgical Management of Fistula-in-ano Among Patients With Crohn's Disease: Analysis of Outcomes After Fistulotomy or Seton Placement-Single-Center Experience.

    PubMed

    Papaconstantinou, I; Kontis, E; Koutoulidis, V; Mantzaris, G; Vassiliou, I

    2017-09-01

    Fistula-in-ano is a common problem among patients with Crohn's disease and carries significant morbidity. We aimed to study the outcomes of surgical treatment of fistula-in-ano after fistulotomy or seton placement in patients with perianal fistulizing Crohn's disease. A retrospective observational study of 59 patients diagnosed with Crohn's disease, who were treated surgically for fistula-in-ano between 2010 and 2014 in our department. The assessment of disease complexity included a detailed physical examination, magnetic resonance imaging of the rectum, and examination under anesthesia. Outcomes for analysis included wound healing rate and postoperative incontinence. High transsphincteric fistula was found in 44% of the patients, while mid or low transsphincteric fistulas were found in 51%. Three women (5%) had a rectovaginal fistula. All patients with high transsphincteric fistulas were treated with loose seton placement. Patients with mid- or low-level transsphincteric fistula were offered either fistulotomy or seton placement based on the clinical evaluation. The mean follow-up duration was 1.6 ± 1.1 years. In terms of recurrence, one patient treated with seton placement presented with recurrence 6 months after seton removal and one patient with fistulotomy failed to achieve wound healing. Minor incontinence was found in six patients treated with fistulotomy and in three patients treated with seton placement; however, this difference was not significant (chi-square = 1.723, df = 1, Monte-Carlo: p = 0.273). Fistulotomy could achieve good results in terms of wound healing and incontinence in strictly selected patients with Crohn's disease suffering from low-lying transsphincteric fistulae. For more high-lying or complicated fistulae, seton placement is more appropriate. For high transsphincteric fistulae, the only option is placement of loose seton.

  2. Potassium and ANO1/TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis

    PubMed Central

    Iqbal, Javed; Tonta, Mary A; Mitsui, Retsu; Li, Qun; Kett, Michelle; Li, Jinhua; Parkington, Helena C; Hashitani, Hikaru; Lang, Richard J

    2012-01-01

    BACKGROUND AND PURPOSE Although atypical smooth muscle cells (SMCs) in the proximal renal pelvis are thought to generate the pacemaker signals that drive pyeloureteric peristalsis, their location and electrical properties remain obscure. EXPERIMENTAL APPROACH Standard patch clamp, intracellular microelectrode and immunohistochemistry techniques were used. To unequivocally identify SMCs, transgenic mice with enhanced yellow fluorescent protein (eYFP) expressed in cells containing α-smooth muscle actin (α-SMA) were sometimes used. KEY RESULTS Atypical SMCs were distinguished from typical SMCs by the absence of both a transient 4-aminopyridine-sensitive K+ current (IKA) and spontaneous transient outward currents (STOCs) upon the opening of large-conductance Ca2+-activated K+ (BK) channels. Many typical SMCs displayed a slowly activating, slowly decaying Cl- current blocked by niflumic acid (NFA). Immunostaining for KV4.3 and ANO1/ TMEM16A Cl- channel subunits co-localized with α-SMA immunoreactive product predominately in the distal renal pelvis. Atypical SMCs fired spontaneous inward currents that were either selective for Cl- and blocked by NFA, or cation-selective and blocked by La3+. α-SMA- interstitial cells (ICs) were distinguished by the presence of a Xe991-sensitive KV7 current, BK channel STOCs and Cl- selective, NFA-sensitive spontaneous transient inward currents (STICs). Intense ANO1/ TMEM16A and KV7.5 immunostaining was present in Kit-α-SMA- ICs in the suburothelial and adventitial regions of the renal pelvis. CONCLUSIONS AND IMPLICATIONS We conclude that KV4.3+α-SMA+ SMCs are typical SMCs that facilitate muscle wall contraction, that ANO1/ TMEM16A and KV7.5 immunoreactivity may be selective markers of Kit- ICs and that atypical SMCs which discharge spontaneous inward currents are the pelviureteric pacemakers. PMID:22014103

  3. [Liver transplant at the UMAE 25 IMSS Monterrey].

    PubMed

    Cisneros-Garza, Laura E; López-Hernández, Pedro A; Muñoz-Ramírez, M del Rosario; Castilla-Valdéz, Martha Patricia; Sebastián-Ruiz, M José; Carmona-Martínez, Juan Gerardo; Alvarez-Treviño, Guillermo Alberto; Martínez-Flores, José Guillermo; Olavide-Aguilar, Ramón

    2011-09-01

    Liver transplantation is the best treatment for end stage liver diseases. In April 2003, our institution started a Liver Transplantation Program for both pediatric and adults population. Shown the results of the Liver Transplantation Program in the UMAE 25 Monterrey N.L. This is a retrospective cohort study of patients with liver transplantation. A total of 51 liver transplantations have been done in 49 patients with two retrasplantation, 15 in children and 36 in adults. The principal indication for liver transplantation in children was biliary atresia and hepatitis C cirrhosis in adults. The acute renal failure was the main early complication, the acute cellular rejection in the mediate period, and the cardiovascular diseases as late complication related to obesity, metabolic syndrome, diabetes mellitus and hypertension. Overall survival at 1 and 5 years was 57.1 and 54.2%, respectively. During the first three years post-transplantation, the quality of life was good or very good. Although still a young and perfectible program, the effort of a multidisciplinary team has made possible to perform liver transplantation in two patient populations, pediatric and adults.

  4. Variação temporal do gradiente radial de o/h a partir de uma amostra de nebulosas planetárias

    NASA Astrophysics Data System (ADS)

    Maciel, W. J.; Costa, R. D. D.; Uchida, M. M. M.

    2003-08-01

    Gradientes radiais de abundância são observados no disco de nossa Galáxia e também em outras galáxias espirais. No caso da Galáxia, o principal problema relativo aos gradientes é sua variação temporal, que constitui um dos principais vínculos aos modelos de evolução química da Galáxia. As nebulosas planetárias são particularmente interessantes no estudo dos gradientes e suas variações, tanto espaciais como temporais. São objetos brilhantes, podendo ser observadas a grandes distâncias, e têm abundâncias relativamente precisas de diversos elementos químicos. Além disso, sendo originadas de estrelas com massas entre 0.8 e 8 massas solares na sequência principal, incluem objetos com idades e populações diferentes, o que as torna especialmente interessantes ao estudo da variação temporal dos gradientes. Neste trabalho, apresentamos resultados recentes sobre a variação temporal do gradiente de O/H a partir de uma amostra contendo cerca de 200 nebulosas, para as quais obtivemos distâncias por métodos estatísticos. As abundâncias foram parcialmente obtidas a partir de observações em Itajubá e La Silla, sendo as restantes obtidas da literatura. Os resultados mostram, pela primeira vez, evidências de um achatamento do gradiente de O/H, de -0.11 dex/kpc para -0.06 dex/kpc nos últimos 9 giga-anos ou de -0.08 dex/kpc para -0.06 dex/kpc nos últimos 5 giga-anos. Esses valores apresentam um bom acordo com alguns modelos recentes para a evolução química da Galáxia. (FAPESP/CNPq)

  5. VizieR Online Data Catalog: Galaxies in the UMa cluster complex (Karachentsev+, 2013)

    NASA Astrophysics Data System (ADS)

    Karachentsev, I. D.; Nasonova, O. G.; Courtois, H. M.

    2015-04-01

    A nearby friable cloud in Ursa Majoris contains 270 galaxies with radial velocities 500UMa complex. According to Makarov & Karachentsev (2011MNRAS.412.2498M, Cat. J/MNRAS/412/2498), most of the UMa galaxies belong to seven bound groups, which have the following median parameters: velocity dispersion of 58k/s, harmonic projected radius of 300kpc, virial mass of 2x1012M⊙ and virial mass-to-K-band luminosity ratio of 27M⊙/L⊙. Almost a half of the UMa cloud population are gas-rich dwarfs (Ir, Im, BCD) with active star formation seen in the GALEX UV-survey. The UMa groups reside within 15-19Mpc from us, being just at the same distance as the Virgo cluster. The total virial mass of the UMa groups is 4x1013M⊙, yielding the average density of dark matter in the UMa cloud to be Ωm=0.08, i.e. a factor of 3 lower than the cosmic average. This is despite the fact that the UMa cloud resides in a region of the Universe that is an apparent overdensity. A possible explanation for this is that most mass in the Universe lies in the empty space between clusters. Herewith, the mean distances and velocities of the UMa groups follow nearly undisturbed Hubble flow without a sign of the 'Z-wave' effect caused by infall towards a massive attractor. This constrains the total amount of dark matter between the UMa groups within the cloud volume. (1 data file).

  6. New Light Curves and Period Studies of V502 OPH W UMA System

    NASA Astrophysics Data System (ADS)

    Awadalla, Nabil S.

    NEW LIGHT CURVES AND PERIOD STUDIES OF V502 OPH W UMa SYSTEM N.S.Awadalla National Research Institute of Astronomy and Geophysics( NRIAG ) Helwan Cairo EGYPT New BVR photoelectric observations of the W UMa eclipsing binary system V502 Oph have been presented and analyzed. The geometric and physical elements of the system have been obtained and compared to the previous results. The classification of the system concerning the sub-type of the W UMa binary has been studied as well as its evolution stage. Its period variation in a view of the light time effect has been examin

  7. Whole exome sequencing links dental tumor to an autosomal-dominant mutation in ANO5 gene associated with gnathodiaphyseal dysplasia and muscle dystrophies

    PubMed Central

    Andreeva, T. V.; Tyazhelova, T. V.; Rykalina, V. N.; Gusev, F. E.; Goltsov, A. Yu.; Zolotareva, O. I.; Aliseichik, M. P.; Borodina, T. A.; Grigorenko, A. P.; Reshetov, D. A.; Ginter, E. K.; Amelina, S. S.; Zinchenko, R. A.; Rogaev, E. I.

    2016-01-01

    Tumors of the jaws may represent different human disorders and frequently associate with pathologic bone fractures. In this report, we analyzed two affected siblings from a family of Russian origin, with a history of dental tumors of the jaws, in correspondence to original clinical diagnosis of cementoma consistent with gigantiform cementoma (GC, OMIM: 137575). Whole exome sequencing revealed the heterozygous missense mutation c.1067G > A (p.Cys356Tyr) in ANO5 gene in these patients. To date, autosomal-dominant mutations have been described in the ANO5 gene for gnathodiaphyseal dysplasia (GDD, OMIM: 166260), and multiple recessive mutations have been described in the gene for muscle dystrophies (OMIM: 613319, 611307); the same amino acid (Cys) at the position 356 is mutated in GDD. These genetic data and similar clinical phenotypes demonstrate that the GC and GDD likely represent the same type of bone pathology. Our data illustrate the significance of mutations in single amino-acid position for particular bone tissue pathology. Modifying role of genetic variations in another gene on the severity of the monogenic trait pathology is also suggested. Finally, we propose the model explaining the tissue-specific manifestation of clinically distant bone and muscle diseases linked to mutations in one gene. PMID:27216912

  8. The Anopheles arabiensis genetic sexing strain ANO IPCL1 and its application potential for the sterile insect technique in integrated vector management programmes.

    PubMed

    Yamada, Hanano; Vreysen, Marc J B; Bourtzis, Kostas; Tschirk, Wolfgang; Chadee, Dave D; Gilles, Jeremie R L

    2015-02-01

    The Anopheles arabiensis genetic sexing strain ANO IPCL1 was developed based on a dieldrin resistant mutation. The strain has been shown to be practical and reliable in terms of female elimination by dieldrin treatments at larval stages, but has provided some difficulties when treatments were applied at the egg stage. The high natural sterility of this strain has advantages and disadvantages in both mass rearing and the sterilization process. In addition, its recombination rate, although relatively low, poses a threat of strain deterioration if left unchecked in a mass-rearing setting. The males of the ANO IPCL1 have been shown to be equally competitive as lab-reared males of the wild-type Dongola strain, but competitiveness decreased by half when irradiated with 75 Gy—a dose conferring >98% sterility. More controversial issues surround the use of dieldrin—a highly persistent organochlorine that is known to bioaccumulate in the food chain. The prospective use of large volumes of dieldrin in a mass-rearing facility and the retention of its residues by the male mosquitoes makes the use of the strain in the context of the sterile insect technique against this vector highly questionable, and therefore its implementation at a large scale cannot be recommended.

  9. Sequential ultrasound-microwave assisted acid extraction (UMAE) of pectin from pomelo peels.

    PubMed

    Liew, Shan Qin; Ngoh, Gek Cheng; Yusoff, Rozita; Teoh, Wen Hui

    2016-12-01

    This study aims to optimize sequential ultrasound-microwave assisted extraction (UMAE) on pomelo peel using citric acid. The effects of pH, sonication time, microwave power and irradiation time on the yield and the degree of esterification (DE) of pectin were investigated. Under optimized conditions of pH 1.80, 27.52min sonication followed by 6.40min microwave irradiation at 643.44W, the yield and the DE value of pectin obtained was respectively at 38.00% and 56.88%. Based upon optimized UMAE condition, the pectin from microwave-ultrasound assisted extraction (MUAE), ultrasound assisted extraction (UAE) and microwave assisted extraction (MAE) were studied. The yield of pectin adopting the UMAE was higher than all other techniques in the order of UMAE>MUAE>MAE>UAE. The pectin's galacturonic acid content obtained from combined extraction technique is higher than that obtained from sole extraction technique and the pectin gel produced from various techniques exhibited a pseudoplastic behaviour. The morphological structures of pectin extracted from MUAE and MAE closely resemble each other. The extracted pectin from UMAE with smaller and more regular surface differs greatly from that of UAE. This has substantiated the highest pectin yield of 36.33% from UMAE and further signified their compatibility and potentiality in pectin extraction. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Ensino de gravitação clássica no nível médio: uma proposta de abordagem e resultados preliminares

    NASA Astrophysics Data System (ADS)

    Medeiros, G. C. M.; Jafelice, L. C.

    2003-08-01

    O ensino de gravitação clássica é comumente realizado de maneira formal e descontextualizado da experiência com a força-peso e da história do tema. Fustigados por anos de experiência de ensino no assunto, nem sempre com bons resultados, propomos uma abordagem ancorada nos eixos: a) contextualização histórica; e b) reconhecimento do peso como a força de atração gravitacional. O primeiro eixo integra o tema no desenvolvimento cultural do ser humano, praticando a interdisciplinaridade. O segundo eixo embasa construtivamente a abordagem, levando o aluno a realizar experiências e a vivenciar o reconhecimento de uma força universal. A abordagem foi construída através das etapas: 1) análise crítica do tema em livros didáticos; 2) elaboração de um curso para professores das várias disciplinas do ensino médio, identificando conexões para a prática da interdisciplinaridade; 3) elaboração de material didático; e 4) avaliação da eficácia da abordagem. No trabalho discutimos em detalhe as quatro etapas. Como resultados, adiantamos que: tabulamos a abordagem de gravitação nos livros didáticos, ainda muito tradicional e carecedora de atividades criativas que poderiam melhor explorar esse assunto; mapeamos, junto aos professores, padrões de conceitos espontâneos e erros associados ao tema; e, no curso, adaptamos e testamos a eficiência de materiais instrucionais existentes e criamos outros novos (e.g., para trabalhar excentricidades das órbitas planetárias), além disto elaboramos roteiros e figuras para tratamentos qualitativo e quantitativo da lei da gravitação universal. As avaliações feitas pelos professores foram muito animadoras. O espaço da presente reunião será aproveitado para socializar a proposta e os resultados obtidos e para submeter o projeto à análise crítica. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP)

  11. Comparison of histopathology and real-time polymerase chain reaction (RT-PCR) for detection of Mycobacterium tuberculosis in fistula-in-ano.

    PubMed

    Garg, Pankaj

    2017-07-01

    Histopathology is commonly used to diagnose tuberculosis in fistula-in-ano. The aim was to compare the sensitivity of polymerase chain reaction and histopathology in detecting tuberculosis in fistula-in-ano. The histopathology and polymerase chain-reaction of tissue (fistula tract) was done in all the consecutive operated cases. When pus sample was also available, polymerase chain reaction-pus was also done RESULTS: Three hundred forty seven samples (179 patients) were tested over 2 years (median 6.5 months). The mean age was 38.8 ± 10.7 years, and male/female was 170/9. Histopathology and polymerase chain reaction of tissue (fistula tract) was done in 152 and 165 patients, respectively. Polymerase chain reaction (pus) could be done in 30 patients. Overall, tuberculosis was detected in 20/179 (11.2%) patients. Of these, tuberculosis was detected by histopathology (tissue) in 1/152 (0.7%) and by polymerase chain reaction (tissue) in 14/165 (8.5%) patients. In pus, polymerase chain reaction detected tuberculosis in 6/30 (20%) patients. Both polymerase chain reaction of tissue and pus were positive in one patient. Polymerase chain reaction (tissue) and polymerase chain reaction (pus) were significantly more sensitive than histopathology (tissue) for detecting tuberculosis [histopathology 1/152 vs. polymerase chain reaction (tissue) 14/165, p = 0.0009] [histopathology 1/152 vs. polymerase chain reaction (pus) 6/30, p < 0.0001]. In 20 patients detected to have tuberculosis, four drug anti-tubercular therapy was recommended for 6 months. The therapy was completed in 13 patients and 12/13 (92.3%) were cured. The therapy is continuing in 3/20 patients. Four patients did not take the therapy. None of them was cured. Polymerase chain reaction was significantly more sensitive than histopathology in detecting tuberculosis in fistula-in-ano. Histopathology might be missing out tuberculosis in many patients leading to recurrence of the fistula.

  12. A Dynamical Analysis of the 47 UMa Planetary System

    NASA Astrophysics Data System (ADS)

    Laughlin, G.; Chambers, J.; Fischer, D.

    2001-12-01

    Thirteen years of Doppler velocity measurements have revealed the presence of two planets orbiting the star 47 Ursa Majoris on low eccentricity orbits. A 2-Keplerian fit to the radial velocity data suggests that the inner planet has a period Pb = 1089.0 +/- 2.9 d, and a nominal mass msin i = 2.54 MJup, while the outer planet has a period Pc = 2594 +/- 90 d, and a mass m sin i = 0.76 MJup. These mass and period ratios suggest a possible kinship to the Jupiter-Saturn pair in our own solar system. We explore the current dynamical state of this system with numerical integrations, and compare the results with analytic secular theory. We find that the planets in the system are likely participating in a secular resonance in which the arguments of pericenter librate around zero. The system may also currently be in a 7:3 mean-motion resonance. Using a self-consistent fitting procedure in conjunction with numerical integrations, we show that stability considerations restrict the mutual inclination between the two planets to 40 degrees or less, and that this result is relatively insensitive to the total mass of the two planets. We present hydrodynamical simulations which measure the torques exerted on the planets by a hypothesized external protoplanetary disk. We show that planetary migration in response to torques from the disk may have led to capture of the system into a 7:3 mean-motion resonance, although it is unclear how the eccentricities of the planets would have been damped after capture occured. We show that Earth-mass planets can survive for long periods in some regions of the habitable zone of the nominal co-planar system. A set of planetary accretion calculations, however, shows that it is unlikely that large terrestrial planets can form in the 47UMa habitable zone. This work was funded by the NASA Origins Program, and by a NASA Ames Director's Discretionary Fund Award.

  13. Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia.

    PubMed

    Vermeer, Sascha; Hoischen, Alexander; Meijer, Rowdy P P; Gilissen, Christian; Neveling, Kornelia; Wieskamp, Nienke; de Brouwer, Arjan; Koenig, Michel; Anheim, Mathieu; Assoum, Mirna; Drouot, Nathalie; Todorovic, Slobodanka; Milic-Rasic, Vedrana; Lochmüller, Hanns; Stevanin, Giovanni; Goizet, Cyril; David, Albert; Durr, Alexandra; Brice, Alexis; Kremer, Berry; van de Warrenburg, Bart P C; Schijvenaars, Mascha M V A P; Heister, Angelien; Kwint, Michael; Arts, Peer; van der Wijst, Jenny; Veltman, Joris; Kamsteeg, Erik-Jan; Scheffer, Hans; Knoers, Nine

    2010-12-10

    Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders. In contrast to their dominant counterparts, unraveling the molecular background of these ataxias has proven to be more complicated and the currently known mutations provide incomplete coverage for genotyping of patients. By combining SNP array-based linkage analysis and targeted resequencing of relevant sequences in the linkage interval with the use of next-generation sequencing technology, we identified a mutation in a gene and have shown its association with autosomal-recessive cerebellar ataxia. In a Dutch consanguineous family with three affected siblings a homozygous 12.5 Mb region on chromosome 3 was targeted by array-based sequence capture. Prioritization of all detected sequence variants led to four candidate genes, one of which contained a variant with a high base pair conservation score (phyloP score: 5.26). This variant was a leucine-to-arginine substitution in the DUF 590 domain of a 16K transmembrane protein, a putative calcium-activated chloride channel encoded by anoctamin 10 (ANO10). The analysis of ANO10 by Sanger sequencing revealed three additional mutations: a homozygous mutation (c.1150_1151del [p.Leu384fs]) in a Serbian family and a compound-heterozygous splice-site mutation (c.1476+1G>T) and a frameshift mutation (c.1604del [p.Leu535X]) in a French family. This illustrates the power of using initial homozygosity mapping with next-generation sequencing technology to identify genes involved in autosomal-recessive diseases. Moreover, identifying a putative calcium-dependent chloride channel involved in cerebellar ataxia adds another pathway to the list of pathophysiological mechanisms that may cause cerebellar ataxia.

  14. Elemental Abundance Analyses with DAO Spectrograms. XXXIX. The Am Stars 2 UMa and 15 Vul

    NASA Astrophysics Data System (ADS)

    Çay, İpek H.; Teker Yelkenci, Aysegul; Adelman, Saul J.

    2016-05-01

    We derived the elemental abundances of the metallic-line stars 2 UMa (=HR 3354; spectral type A2m) and 15 Vul (=HR 7653; spectral type A4 III), using high-dispersion, high signal-to-noise ratio (≥200) optical region spectrograms obtained with CCD detectors at the long Coudé camera of the 1.22 m telescope of the Dominion Astrophysical Observatory (DAO) and Kurucz's ATLAS9 and WIDTH9 programs. The star 2 UMa has not been the subject of a modern detailed elemental abundances analysis. It is relatively sharp-lined and sufficiently hot (T eff = 8050 K) that the continuum placement is not a major problem in the optical region. Comparison of the results of this new study of 15 Vul with the last complete study shows a 0.15 dex mean increase in the derived abundances and a reduction in the standard deviations of the mean values. The abundance anomalies of 2 UMa are usually larger than those of 15 Vul. The greater spectral coverage of 15 Vul compared with 2 UMa results in a larger number of abundances being derived. The abundances of 2 UMa are typical for those of classical Am stars that have similar effective temperatures and surface gravities. 15 Vul, characterized by a similar effective temperature and smaller surface gravity, is a more evolved star.

  15. High-frequency variations of hydrogen spectral lines in the B3V star η UMa

    NASA Astrophysics Data System (ADS)

    Pokhvala, S. M.

    2015-09-01

    We reported the detection of high-frequency variations in the hydrogen Balmer lines in the hot star η UMa of spectral class B3V. Spectral observations of η UMa were carried out with slitless spectrograph (R˜100) installed on the 60 cm Carl Zeiss telescope in the Andrushivka Observatory. Spectra were obtained with a time resolution in the sub-second range. It has been found that the η UMa shows rapid variations in the hydrogen lines Hα, Hβ, Hγ, as well as variations in the atmospheric oxygen lines. The intensity variations in the hydrogen lines varies from 0.2% to 0.5% , and that of the oxygen lines is approximately 2%.

  16. FUSE Observations of the Bright, Eclipsing Nova-like Cataclysmic Variable, UX UMa (FUSE 2000)

    NASA Technical Reports Server (NTRS)

    Long, Knox; Froning, Cynthia

    2004-01-01

    This was a project to study the disk and wind of the eclipsing nova-like variable UX UMa, in order to better define the wind geometry of the system, including the nature of the transition region between the disk photosphere and the supersonic wind. We proposed to use phase resolved spectroscopy of the system, taking advantage of the fact that UX UMa is an eclipsing system, to isolate different regions of the wind and to use a Monte Carlo radiative transfer code to simulate the spectra through the eclipse.

  17. Providing Meaningful Learning for Students of the Sixth Grade of Middle School: a Study on the Moon Phases. (Breton Title: Propiciando Aprendizagem Significativa Para Alunos do Sexto Ano do Ensino Fundamental: um Estudo sobre as Fases da Lua.) Propiciando el Aprendizaje Significativo Para Alumnos del Sexto Nivel de la Educación General Básica: un Estudio sobre Las Fases de la Luna

    NASA Astrophysics Data System (ADS)

    Darroz, Luiz Marcelo; Samudio Pérez, Carlos Ariel; da Rosa, Cleci Werner; Heineck, Renato

    2012-07-01

    We relate in this article a didactic experience studying the moon phases with a group of middle school students of a private school of the municipality of Passo Fundo, RS. Based on David Ausubel's Meaningful Learning Theory, we have sought to develop a proposal following a didactic model which simulates the phases of the Moon, as based on the previous conceptions of the students. The signs of learning were evidenced by means of memory registries of the activity. From the obtained results we believe that the proposal achieved its goals, since the students were able to identify, differentiate and transfer the phenomenon of the moon phases to new contexts. Thus, it is concluded that a methodology focused on a meaningful content for the students is fundamental to the construction and genuine grasping of what is being learned. Neste artigo, relata-se uma experiência didática de estudo das fases da Lua com uma turma do 6° ano do Ensino Fundamental, de uma escola privada do município de Passo Fundo, RS. Tendo como fundamentação teórica a Teoria da Aprendizagem Significativa de David Ausubel, buscou-se desenvolver a proposta a partir de um modelo didático que simula as fases da Lua e com base nas concepções prévias dos estudantes. Os indícios da aprendizagem foram constatados através de registros de memórias da atividade. Pelos resultados apresentados, acredita-se que a proposta alcançou seus objetivos, uma vez que os estudantes conseguiram identificar, diferenciar e transferir o fenômeno das fases da Lua para novos contextos. Assim, conclui-se que uma metodologia com enfoque em um conteúdo significativo ao estudante é fundamental para a construção e compreensão genuína do que está sendo aprendido. En este artículo se relata una experiencia didáctica de estudio de las fases de la Luna con una clase de 6º año de la educación general básica de una escuela privada del municipio de Passo Fundo, RS. Teniendo como fundamentación teórica la Teor

  18. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.

    PubMed

    Piechowicz, Katarzyna A; Truong, Eric C; Javed, Kashif M; Chaney, Rachelle R; Wu, Johnny Y; Phuan, Puay W; Verkman, Alan S; Anderson, Marc O

    2016-12-01

    Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca(2+) activated Cl(-) channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole T16Ainh-01 was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in T16Ainh-01. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. We found that very little structural variation of T16Ainh-01 was tolerated, with most compounds showing no activity at 10 μM. The most potent compound in the series, 9bo, which substitutes 4-methoxyphenyl in T16Ainh-01 with 2-thiophene, had IC50 ∼1 μM for inhibition of TMEM16A chloride conductance.

  19. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1

    PubMed Central

    Piechowicz, Katarzyna A.; Truong, Eric C.; Javed, Kashif M.; Chaney, Rachelle R.; Wu, Johnny Y.; Phuan, Puay W.; Verkman, Alan S.; Anderson, Marc O.

    2016-01-01

    Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca2+ activated Cl− channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole T16Ainh-01 was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in T16Ainh-01. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. We found that very little structural variation of T16Ainh-01 was tolerated, with most compounds showing no activity at 10 µM. The most potent compound in the series, 9bo, which substitutes 4-methoxyphenyl in T16Ainh-01 with 2-thiophene, had IC50 ~1 µM for inhibition of TMEM16A chloride conductance. PMID:26796863

  20. Bonding trends across the series of tricarbonato-actinyl anions [(AnO2)(CO3)3](4-) (An = U-Cm): the plutonium turn.

    PubMed

    Liu, Jian-Biao; Chen, Guo P; Huang, Wei; Clark, David L; Schwarz, W H Eugen; Li, Jun

    2017-02-21

    Actinyl-tricarbonato anions [(AnO2)(CO3)3](4-) (An = U-Cm) in various environments were investigated using theoretical approaches of quantum-mechanics, molecular-mechanics and cluster-models. Cations and solvent molecules in the 2(nd) coordination sphere affect the equatorial An←Oeq bonds more than the axial An[triple bond, length as m-dash]Oax bonds. Common actinide contraction is found for calculated and experimental axial bond lengths of 92U to 94Pu, though no longer for 94Pu to 96Cm. The tendency of U to Pu forming actinyl(vi) species dwindles away toward Cm, which already features the preferred An(III)/Ln(III) oxidation state of the later actinides and all lanthanides. The well known change from d-type to typical U-Pu-Cm type and then to f-type behavior is labeled as the plutonium turn, a phenomenon that is caused by f-orbital energy-decrease and f-orbital localization with increase of both nuclear charge and oxidation state, and a non-linear variation of effective f-electron population across the actinide series. Both orbital and configuration mixing and occupation of antibonding 5f type orbitals increase, weakening the AnOax bonds and reducing the highest possible oxidation states of the later actinides.

  1. MN Dra - a SU UMa-type star during its September 2013 superoutburst

    NASA Astrophysics Data System (ADS)

    Bąkowska, Karolina; Olech, Arkadiusz; Pospieszyński, Remigiusz

    2016-06-01

    We report CCD photometry of the cataclysmic variable star MN Draconis. During the season of August-September 2013, one normal outburst and one superoutburst were detected. In the light curves of MN Dra clear superhumps were present during September 2013 superoutburst. That fact confirms that the star is a member of SU UMa class.

  2. Genome Sequences of Gordonia Bacteriophages Obliviate, UmaThurman, and Guacamole

    PubMed Central

    Akbar, Armaan F.; Ayers, Taylor N.; Belohoubek, Selena G.; Chung, Connie F.; Hartman, Allison C.; Kayiti, Tejus; Kessler, Cecilia M.; Koman, Philipp I.; Kotovskiy, Grigoriy A.; Morgan, Taylor M.; Rohac, Rebecca M.; Silva, Gabriela M.; Willis, Charles E.; Milliken, Katherine A.; Shedlock, Kathleen A.; Stanton, Ann-Catherine J.; Toner, Chelsea L.; Furbee, Emily C.; Grubb, Sarah R.; Warner, Marcie H.; Montgomery, Matthew T.; Garlena, Rebecca A.; Russell, Daniel A.; Jacobs-Sera, Deborah; Hatfull, Graham F.

    2016-01-01

    We describe three newly isolated phages—Obliviate, UmaThurman, and Guacamole—that infect Gordonia terrae 3612. The three genomes are related to one another but are not closely related to other previously sequenced phages or prophages. The three phages are predicted to use integration-dependent immunity systems as described in several mycobacteriophages. PMID:27365348

  3. Baseline findings from the Anal Cancer Examination (ACE) study: screening using digital ano-rectal examination in HIV-positive men who have sex with men.

    PubMed

    Ong, Jason J; Grulich, Andrew; Walker, Sandra; Hoy, Jennifer; Read, Tim; Bradshaw, Catriona; Garland, Suzanne M; Hillman, Richard; Templeton, David; Hocking, Jane; Eu, Beng; Tee, B K; Fairley, Christopher K

    2016-06-01

    Cytological screening for anal cancer precursors is not always possible. We investigated digital ano-rectal examination (DARE) as a means of early anal cancer detection in HIV-positive men who have sex with men (MSM). We recruited 327 HIV-positive MSM aged 35 and over from clinics with HIV physicians in Melbourne, Australia, to receive an annual DARE. We analyzed baseline data from patient questionnaires regarding general, anal and sexual health, adverse effects from the anal examination, cancer worry, and quality of life. The majority of men (82%, 95% CI:78-87) felt relaxed during the DARE, 1% (95% CI:0-3) complained of pain, and 1% (95% CI:0-4) reported bleeding after the examination. Nearly all men (99%, 95% CI:96-100) were willing to continue with an annual DARE. Quality of life was unaffected with utility scores of 0.76 before examination vs. 0.77 two weeks after examination, (p = 0.41). An anal abnormality was detected in 86 men (27%, 95% CI:22-31), with one anal cancer identified. The specialist referral rate following DARE was 5% (95% CI:3-8). Recruitment rates were significantly associated with the clinic setting (sexual health centre 78%, general practice 13%, hospital 14%, p = 0.002) and specialty (sexual health physician 67%, general practitioner 20%, infectious disease physician 14%, p = 0.031). Annual DARE to detect anal cancer in HIV-positive MSM was acceptable for patients, with minimal side effects. Strategies to increase HIV physician's patient recruitment would be needed if DARE were to be implemented in anal cancer screening. © The Author(s) 2015.

  4. Static electric dipole polarizabilities of An5+/6+ and AnO2+/2+ (An = U, Np, and Pu) ions

    NASA Astrophysics Data System (ADS)

    Parmar, Payal; Peterson, Kirk A.; Clark, Aurora E.

    2014-12-01

    The parallel components of static electric dipole polarizabilities have been calculated for the lowest lying spin-orbit states of the penta- and hexavalent oxidation states of the actinides (An) U, Np, and Pu, in both their atomic and molecular diyl ion forms (An5+/6+ and AnO2+/2+) using the numerical finite-field technique within a four-component relativistic framework. The four-component Dirac-Hartree-Fock method formed the reference for MP2 and CCSD(T) calculations, while multireference Fock space coupled-cluster (FSCC), intermediate Hamiltonian Fock space coupled-cluster (IH-FSCC) and Kramers restricted configuration interaction (KRCI) methods were used to incorporate additional electron correlation. It is observed that electron correlation has significant (˜5 a.u.3) impact upon the parallel component of the polarizabilities of the diyls. To the best of our knowledge, these quantities have not been previously reported and they can serve as reference values in the determination of various electronic and response properties (for example intermolecular forces, optical properties, etc.) relevant to the nuclear fuel cycle and material science applications. The highest quality numbers for the parallel components (αzz) of the polarizability for the lowest Ω levels corresponding to the ground electronic states are (in a.u.3) 44.15 and 41.17 for UO2+ and UO22+, respectively, 45.64 and 41.42 for NpO2+ and NpO22+, respectively, and 47.15 for the PuO2+ ion.

  5. Static electric dipole polarizabilities of An(5+/6+) and AnO2 (+/2+) (An = U, Np, and Pu) ions.

    PubMed

    Parmar, Payal; Peterson, Kirk A; Clark, Aurora E

    2014-12-21

    The parallel components of static electric dipole polarizabilities have been calculated for the lowest lying spin-orbit states of the penta- and hexavalent oxidation states of the actinides (An) U, Np, and Pu, in both their atomic and molecular diyl ion forms (An(5+/6+) and AnO2 (+/2+)) using the numerical finite-field technique within a four-component relativistic framework. The four-component Dirac-Hartree-Fock method formed the reference for MP2 and CCSD(T) calculations, while multireference Fock space coupled-cluster (FSCC), intermediate Hamiltonian Fock space coupled-cluster (IH-FSCC) and Kramers restricted configuration interaction (KRCI) methods were used to incorporate additional electron correlation. It is observed that electron correlation has significant (∼5 a.u.(3)) impact upon the parallel component of the polarizabilities of the diyls. To the best of our knowledge, these quantities have not been previously reported and they can serve as reference values in the determination of various electronic and response properties (for example intermolecular forces, optical properties, etc.) relevant to the nuclear fuel cycle and material science applications. The highest quality numbers for the parallel components (αzz) of the polarizability for the lowest Ω levels corresponding to the ground electronic states are (in a.u.(3)) 44.15 and 41.17 for UO2 (+) and UO2 (2+), respectively, 45.64 and 41.42 for NpO2 (+) and NpO2 (2+), respectively, and 47.15 for the PuO2 (+) ion.

  6. Non-sphincter splitting fistulectomy vs conventional fistulotomy for high trans-sphincteric fistula-in-ano: a prospective functional and manometric study.

    PubMed

    Toyonaga, Takayuki; Matsushima, Makoto; Tanaka, Yoshiaki; Suzuki, Kazunori; Sogawa, Nobuhito; Kanyama, Hiroki; Shimojima, Yasuhiro; Hatakeyama, Tomoaki; Tanaka, Masao

    2007-09-01

    This study compared the clinical and physiological results of non-sphincter splitting fistulectomy (N-SSF) with those of sphincter splitting fistulotomy (SSF) for treatment of high trans-sphincteric fistula-in-ano. A prospective, observational study was undertaken in 70 consecutive patients with high trans-sphincteric fistula treated by SSF (n = 35) or N-SSF (n = 35). Anal manometry was performed before and 3 months after surgery. Anal continence was assessed using the Cleveland Clinic Florida Incontinence Score. There was no difference between the two groups in age, gender, presence of horseshoe extension, preoperative incontinence score and manometric values. The incidence of recurrence was similar between the two groups. The postoperative incontinence score of the SSF group was significantly higher than that of the N-SSF group (1.9 +/- 2.9 vs 1.1 +/- 2.9, P = 0.0347). Maximum resting pressure showed significant decrease after surgery in both groups (83.2 to 56.1 mmHg, P = 0.0001 and 85.1 to 58.4 mmHg, P = 0.0001). Voluntary contraction pressure and functional anal canal length did not change after N-SSF (137.6 to 138.2 mmHg, P = 0.9524 and 4.06 to 4.07 cm, P = 0.9524), but significantly decreased after SSF (120.2 to 96.7 mmHg, P = 0.0085 and 4.12 to 3.74 cm, P = 0.0183). Non-sphincter splitting fistulectomy for high trans-sphincteric fistula provided better functional results than fistulotomy. Less impairment of anal continence was achieved possibly not only by maintenance of the external anal sphincter function but also by preservation of the length of the high-pressure zone.

  7. OA03.11. A comparative study of guggulu chitrak kshar – sutra and snuhi apamarg kshar – sutra in the management of fistula in ano

    PubMed Central

    Gond, Pushpa; Kumar, Ashok; Rajeshwari, PN; Choudhary, PC; Kumar, Jitendra

    2013-01-01

    Purpose: Fistula in ano is a condition which has been recognized as difficult surgical diseases in all the ancient and modern medical sciences of the world. In Ayurvedic texts fistulainano is described as Bhagandar. This disease is recurrent in nature which makes it more difficult for treatment. So it produces inconvenience in routine life. KsharSutra has been proved as a big revolution in the treatment of fistulainano. It is the need to do further researches to get more efficient Kshar Sutra. Method: The present study was clinical, randomised, single blind trial. In the present research work Guggulu Chitraka KsharSutra has been taken for comparative study wth snuhi apamarga ksharsutra. Thirty patients cases of fistulainano were selected from OPD/IPD of Shalya Tantra department of National Institute of Ayurveda, Jaipur. Total patients were divided into two equal groups. The patients of group A were treated with Snuhi Apamarga KsharSutra and the patients of group B were treated with Guggulu Chitraka KsharSutra. Result: In the study the effect of Guggulu Chitraka KsharSutra was found better in pain, itching, pus discharge, tenderness and burning sensation and the rate of Unit Cutting Time was slightly higher as Snuhi Apamarga KsharSutra. Conclusion: Though U.C.T of Guggulu Chitrak Kshara Sutra is slightly higher than Snuhi Apamarga Kshar Sutra, but in assessment parameter Guggulu Chitrak Kshar Sutra has been shown significant result. With guggulu chitrak ksharsutra post ligation complications like hypertrophied scar etc are not seen and this is easily available and cost effective.

  8. Functional characterization of CD4 and CD8 T cell responses among human papillomavirus infected patients with ano-genital warts.

    PubMed

    Singh, Manjula; Thakral, Deepshi; Rishi, Narayan; Kar, Hemanta Kumar; Mitra, Dipendra Kumar

    2017-06-01

    Ano-genital warts are considered one of the commonest and highly infectious sexually transmitted infections. These warts are primarily caused by the human papillomavirus (HPV) of the family Papillomaviridae, genus alpha-papillomavirus, species 10 and types 6 and 11. However the high recurrence rate of warts is a matter of serious concern to the patients and a challenge for the treating physician. The conventional treatment options are targeted only to the local site of warts. There is no systemic treatment modality as there is limited understanding of the disease immune-pathogenesis. The role of cell-mediated immunity in combating HPV infection is not clearly defined. Hence the present study is aimed at investigating the CD4(+) T helper (Th1 and Th2) and CD8(+) T cell responses among wart patients. In this study, we compared HPV6 and HPV11 antigen-specific T cell responses among venereal wart patients relative to healthy controls. Significant decrease in percent frequencies of IFN-γ producing CD4(+) and CD8(+) T cells were observed in HPV infected wart patients. On the other hand, the frequency of CD4(+) T cells expressing IL-4 was significantly increased in these patients as compared to healthy controls. The observed functional skewing of HPV specific T cells from Th1 to Th2 response in patients indicated suppressed immunity against the HPV. Moreover, decrease in CD8 T cell function correlated with poor wart clearance. Our findings open future avenues for exploring potential immunomodulation strategies as an adjunct to standard treatment for better management of these patients and prevention of recurrence.

  9. Absolute and geometric parameters of the W UMa type contact binary V546 And

    NASA Astrophysics Data System (ADS)

    Gürol, Birol; Bradstreet, David H.; Okan, Abdullah

    2015-04-01

    We present the results of our investigation on the geometrical and physical parameters of the W UMa-type binary V546 And from analyzed CCD (BVRI) light curves and radial velocity data. The photometric data were obtained in 2010 and 2011 at Ankara University Observatory (AUO) and the spectroscopic observations were made in 2010 at TUBITAK National Observatory (TUG). Light and radial velocity observations were analyzed simultaneously by using the Wilson-Devinney (2013 revision) code to obtain absolute and geometrical parameters. The system was determined to be a W-type W UMa system. Combining our photometric solution with the spectroscopic data we derived masses and radii of the eclipsing system to be M1 = 0.275M⊙,M2 = 1.083M⊙,R1 = 0.661R⊙ and R2 = 1.229R⊙ . We finally discuss the evolutionary status of the system.

  10. LX Leo: A High Mass-Ratio Totally Eclipsing W-type W UMa System

    NASA Astrophysics Data System (ADS)

    Gürol, B.; Michel, R.; Gonzalez, C.

    2017-10-01

    We present the results of our investigation of the geometrical and physical parameters of the binary system LX Leo. Based on CCD BVRc light curves, and their analyses with the Wilson-Devinney code, new times of minima and light elements have been determined. According to our solution, the system is a high mass-ratio, totally eclipsing, W-type W UMa system. Combining our photometric solution with the empirical relation for W UMa type systems by Dimitrow & Kjurkchieva (2015), we derived the masses and radii of the components to be M1=0.43 Mȯ, M2=0.81 Mȯ, R1=0.58 Rȯ and R2=0.77 Rȯ. In addition, the evolutionary condition of the system is discussed.

  11. Spectral and photometric behavior of SU UMa during quiescence and outburst states

    NASA Astrophysics Data System (ADS)

    Zead, I.; Saad, S. M.; Sanad, M. R.; Behary, M. M.; Gadallah, K.

    2017-04-01

    We report the results of spectral and photometric observations of SU UMa. Available spectra from International Ultraviolet Explorer (IUE) and CCD photometry of five nights were used. Some profiles revealing the variations of some spectral lines at different times are presented. There is variation with time for photometric observations and the brightness of SU UMa is changed from 12.9 mag. to 15.6 mag in 5 nights with clear display of burst. The ultraviolet luminosity for emitting region is in the range of (6.9*1030 erg s-1). The mass accretion rate is in the range of (9.8*10-13 M⊙yr-1). The line flux modulations at different times can be explained in terms of the mass transfer instability model (Bath 1973).

  12. About DR UMa or the CRTS transient CSS110402:135906+554432

    NASA Astrophysics Data System (ADS)

    Lampens, Patricia,; Van Cauteren, Paul

    2017-03-01

    We report differential photometric measurements, both unfiltered (filter clear, C) and filtered (filter V), obtained at the Humain station of the Royal Observatory of Belgium (longitude = 5.254, latitude = +50.192, elevation = 280 m) of the CRTS transient CSS110402:135906+554432 (Drake et al. 2009, ApJ 696, 870), which is also identified as DR UMa. The instrumentation is a 16-inch Schmidt-Cassegrain telescope equipped with a Moravian G2-3200 CCD camera.

  13. Increasing Supercycle Lengths of Active SU UMa-type Dwarf Novae

    NASA Astrophysics Data System (ADS)

    Otulakowska-Hypka, M.; Olech, A.

    2014-12-01

    We present observational evidence that supercycle lengths of the most active SU UMa-type stars are increasing during the past decades. We analyzed a large number of photometric measurements from available archives and found that this effect is generic for this class of stars, independently of their evolutionary status. This finding is in agreement with previous predictions and the most recent work of Patterson et al. (2012) on BK Lyn.

  14. A cool stellar companion to the δ Scuti variable star GW UMa

    NASA Astrophysics Data System (ADS)

    Wang, S.-M.; Qian, S.-B.; Li, L.-J.; Zhu, L.-Y.; Zhao, E.-G.; Zhou, X.

    2015-01-01

    GW UMa is a new high-amplitude δ Scuti variable star with a period of 0d.20319367. By using a few new determined times of light maximum together with those collected from the literature, the changes in Observed-Calculated (O-C) diagram were analyzed. It is discovered that the O-C curve of GW UMa shows a cyclic variation with a period of 13.2 years and a semi-amplitude of 0.0023 days. The periodic variation was analyzed for the light-travel time effect that may be due to the presence of a stellar companion. The mass of the stellar companion is determined to be M2 sin i=0.11(±0.01)M⊙ when a mass of 1.76 M⊙ for GW UMa is adopted. The two component stars in the binary system are orbiting each other at an orbital separation about 6.5(±0.8) AU. For orbital inclinations i⩾22.6°, the mass of the companion star would be M2<0.3M⊙ and it is a fully convective star. The detection suggests that hidden stellar companions to bright stars may be not unusual.

  15. Curious Variables Experiment (CURVE). Superhump Period Change Pattern in KS UMa and Other Dwarf Novae

    NASA Astrophysics Data System (ADS)

    Olech, A.; Schwarzenberg-Czerny, A.; Kedzierski, P.; Zloczewski, K.; Mularczyk, K.; Wisniewski, M.

    2003-06-01

    We report extensive photometry of the dwarf nova KS UMa throughout its 2003 superoutburst till quiescence. During the superoutburst the star displayed clear superhumps with a mean period of P_sh=0.070092(23) days. In the middle stage of superoutburst the period was increasing with a rate of dot P/P=(21+/-12)*10^-5 and later was decreasing with a rate of dot P/P=-(21+/-8)*10^-5. At the end of superoutburst and during first dozen days of quiescence the star was showing late superhumps with a mean period of P_late=0.06926(2) days. This phenomenon was observed even 30 days after beginning of the superoutburst. In quiescence the star shows quasi-periodic modulations with amplitude reaching 0.5 mag. The most common structure observed during this stage was sinusoidal wave characterized by a period of about 0.1 days. Comparing KS UMa to other SU UMa stars we conclude that this group of dwarf novae shows decreasing superhump periods at the beginning and the end of superoutburst but increasing period in the middle phase.

  16. UBVRI analysis of the totally eclipsing extreme mass ratio W UMa binary, GSC 3208 1986

    SciTech Connect

    Samec, R. G.; Kring, J. D.; Robb, Russell; Van Hamme, W.; Faulkner, D. R.

    2015-03-01

    GSC 3208 1986 is an NSVS and TYCHO binary, first observed from 1999 to 2000. It is a W UMa binary with a period of 0.405 days. The present observations were taken in 2012 September and are of high precision, averaging a standard deviation of better than 5 mmag. The amplitude of the light curve is very nearly 0.5 mag yet it undergoes total eclipses. Dominion Astrophysical Observatory spectra give an F3V type (T∼6900 K) for the system, the earliest of the extreme mass ratio W UMa binaries. The linear period determination of 0.4045672 days was calculated with the two sets of epochs available. An early NSVS light curve reveals that the period has been smoothly decreasing over its past 12,000 orbits. The binary may be undergoing sinusoidal oscillations due to the presence of a third body, possibly with a period of 23±3 years. The high inclination of 85° results in a long duration secondary total eclipse, lasting some 49.5 minutes. Findings indicate that GSC 3208 1986 is an immaculate extreme mass ratio, q(m{sub 2}/m{sub 1}) = 0.24, A-type W UMa binary.

  17. Five years of experience with the FiLaC™ laser for fistula-in-ano management: long-term follow-up from a single institution.

    PubMed

    Wilhelm, A; Fiebig, A; Krawczak, M

    2017-04-01

    There are limited data available concerning endofistular therapies for fistula-in-ano, with our group reporting the first preliminary outcomes of the use of the radial fibre Fistula laser Closing (FiLaC ™) device. The aim of this study was to assess a cohort of anal fistulae managed with laser ablation plus definitive flap closure of the internal fistula opening over a long-term follow-up. Factors governing primary healing success and secondary healing success (i.e. success after one or two operations) were determined. The study analysed 117 patients over a median follow-up period of 25.4 months (range 6-60 months) with 13 patients (11.1%) having Crohn's-related fistulae. No incontinence to solid and liquid stool was reported. Minor incontinence to mucus and gas was observed in two cases (1.7%), and a late abscess treated in one case (0.8%). The primary healing rate was 75/117 (64.1%) overall, and 63.5% for cryptoglandular fistulae versus 69.2% for Crohn's fistulae, respectively. Of the 42 patients who failed FiLaC™ 31 underwent a second operation ("Re-FiLaC™", fistulectomy with sphincter reconstruction or fistulotomy). The secondary healing rate, defined as healing of the fistula at the end of the study period, was 103/117 (88.0%) overall and 85.5% for cryptoglandular fistulae versus 92.3% for Crohn's fistulae. A significantly higher primary success rate was observed for intersphincteric-type fistulae with primary and secondary outcome unaffected by age, gender, presence of Crohn's disease, number of prior surgeries and the type of flap designed to close the internal fistula opening. There is a moderate primary success rate using first-up FiLaC™ treatment. If FiLaC™ fails, secondary success with repeat FiLaC™ or other approaches was high. The minimally invasive FiLaC™ approach may therefore represent a sensible first-line treatment option for anal fistula repair.

  18. Optimization and comparison of ultrasound/microwave assisted extraction (UMAE) and ultrasonic assisted extraction (UAE) of lycopene from tomatoes.

    PubMed

    Lianfu, Zhang; Zelong, Liu

    2008-07-01

    The extracting technology including ultrasonic and microwave assisted extraction (UMAE) and ultrasonic assisted extraction (UAE) of lycopene from tomato paste were optimized and compared. The results showed that the optimal conditions for UMAE were 98 W microwave power together with 40 KHz ultrasonic processing, the ratio of solvents to tomato paste was 10.6:1 (V/W) and the extracting time should be 367 s; as for UAE, the extracting temperature was 86.4 degrees C, the ratio of the solvents to tomato paste was 8.0:1 (V/W) and the extracting time should be 29.1 min, while the percentage of lycopene yield was 97.4% and 89.4% for UMAE and UAE, respectively. These results implied that UMAE was far more efficient extracting method than UAE.

  19. Kīlauea summit eruption—Lava returns to Halemaʻumaʻu

    USGS Publications Warehouse

    Babb, Janet L.; Wessells, Stephen M.; Neal, Christina A.

    2017-10-06

    In March 2008, a new volcanic vent opened within Halemaʻumaʻu, a crater at the summit of Kīlauea Volcano in Hawaiʻi Volcanoes National Park on the Island of Hawaiʻi. This new vent is one of two ongoing eruptions on the volcano. The other is on Kīlauea’s East Rift Zone, where vents have been erupting nearly nonstop since 1983. The duration of these simultaneous summit and rift zone eruptions on Kīlauea is unmatched in at least 200 years.Since 2008, Kīlauea’s summit eruption has consisted of continuous degassing, occasional explosive events, and an active, circulating lava lake. Because of ongoing volcanic hazards associated with the summit vent, including the emission of high levels of sulfur dioxide gas and fragments of hot lava and rock explosively hurled onto the crater rim, the area around Halemaʻumaʻu remains closed to the public as of 2017.Through historical photos of past Halemaʻumaʻu eruptions and stunning 4K imagery of the current eruption, this 24-minute program tells the story of Kīlauea Volcano’s summit lava lake—now one of the two largest lava lakes in the world. It begins with a Hawaiian chant that expresses traditional observations of a bubbling lava lake and reflects the connections between science and culture that continue on Kīlauea today.The video briefly recounts the eruptive history of Halemaʻumaʻu and describes the formation and continued growth of the current summit vent and lava lake. It features USGS Hawaiian Volcano Observatory scientists sharing their insights on the summit eruption—how they monitor the lava lake, how and why the lake level rises and falls, why explosive events occur, the connection between Kīlauea’s ongoing summit and East Rift Zone eruptions, and the impacts of the summit eruption on the Island of Hawaiʻi and beyond. The video is also available at the following U.S. Geological Survey Multimedia Gallery link (video hosted on YouTube): Kīlauea summit eruption—Lava returns to Halemaʻumaʻu

  20. Cosmoeducação: uma proposta para o ensino de astronomia

    NASA Astrophysics Data System (ADS)

    Medeiros, L. A. L.; Jafelice, L. C.

    2003-08-01

    Entende-se por cosmoeducação o desenvolvimento vivencial da unidade homem-cosmo. Este conceito é norteado pela psicologia transpessoal, que estuda o ser humano em sua totalidade, onde suas relações ecológicas e cósmicas são de grande importância. Constata-se uma necessidade latente no ser humano moderno em resgatar uma relação holística com o Universo. Neste trabalho exploramos meios de cultivar a consciência de que o ser humano constitui parte integrante do cosmo e se relaciona com este com o objetivo de promover em si uma percepção ambiental mais ampla. Nossa hipótese de trabalho inicial foi que o ensino de conteúdos básicos em astronomia realizado através de uma abordagem holística, que incorpore práticas vivenciais correlacionadas àqueles conteúdos, pode despertar no indivíduo sua identidade cósmica. O método que utilizamos é o fenomenológico e o universo desta pesquisa é um grupo de estudantes da disciplina de Astronomia (Curso de Licenciatura em Geografia/UFRN), onde realizamos observação participante, entrevistas, depoimentos e as práticas vivenciais mencionadas. Neste caso estamos desenvolvendo e adaptando exercícios de algumas técnicas terapêuticas de psicologia transpessoal, que um de nós (LALM) tem aplicado no contexto clínico, para trabalhar aspectos cognitivos envolvidos naquele processo de conscientização cósmica. Resultados parciais claramente referendam a hipótese inicial. Um resultado a destacar é fruto de uma dinâmica de representação corporal interiorizada do eclipse lunar, envolvendo um pequeno grupo daqueles estudantes, na qual conteúdos míticos afloraram de maneira espontânea e contundente para todos, sugerindo ressonância, ou pelo menos isomorfismo, entre o macro e o microcosmo. Este e outros resultados são discutidos em detalhe neste trabalho. (PPGECNM/UFRN; PRONEX/FINEP; NUPA/USP; Temáticos/FAPESP).

  1. O Passado como Nacao: Imagens do Imperio nas Falas Reacionarias dos Anos 30 e 40 do Seculo XX: Uma Pequena Arqueologia do Debate Publico e Privado (The Past as Nation: Images of the Empire in the Reactionary Words of the 30s and 40s in the 20th Century: A Small Archaeology of the Public Debate versus the Private One).

    ERIC Educational Resources Information Center

    de Freitas, Marcos Cezar

    1998-01-01

    Suggests an archaeology of the public debate versus the private one in Brazil through analysis of the reactionary speech of a religious leader, Dom Jose Mauricio da Rocha, which produced innumerable representations of the Brazilian Empire. (PA)

  2. O Passado como Nacao: Imagens do Imperio nas Falas Reacionarias dos Anos 30 e 40 do Seculo XX: Uma Pequena Arqueologia do Debate Publico e Privado (The Past as Nation: Images of the Empire in the Reactionary Words of the 30s and 40s in the 20th Century: A Small Archaeology of the Public Debate versus the Private One).

    ERIC Educational Resources Information Center

    de Freitas, Marcos Cezar

    1998-01-01

    Suggests an archaeology of the public debate versus the private one in Brazil through analysis of the reactionary speech of a religious leader, Dom Jose Mauricio da Rocha, which produced innumerable representations of the Brazilian Empire. (PA)

  3. BO Canum Venaticorum and SS Comae Berenices: A Photometric Study of AW UMa-Type Binaries

    NASA Astrophysics Data System (ADS)

    Qian, S.-B.; Zhu, L.-Y.

    2006-02-01

    BO CVn and SS Com are two short-period W UMa-type binary stars with spectral types earlier than F5. In the present paper new CCD photometric light curves in B, V, and R bands of BO CVn and the first complete light curve in V band of SS Com are presented. The light curves of the two binaries are symmetric, and no variations of the light curves were found for both systems that are quite unlike those of cooler overcontact binaries. These observational properties may suggest weak photospheric dark spot activity in the two systems during the observational time intervals. Photometric solutions of the two W UMa-type binaries were derived by using the 2003 version of the Wilson-Devinney (W-D) method. The new solutions suggest that they are overcontact binary stars with degrees of overcontact of f=40.6% for BO CVn and f=49.6% for SS Com. Our new times of light minimum confirmed the long-time period increases of the two systems, and the rates of continuous period increase were revised. The long-time period increases, the orbital periods, the degrees of overcontact, and the mass ratios all suggest that they are on an evolutionary stage of mass transfer from the less massive component to the more massive one, and SS Com will reach the present evolutionary state of BO CVn. The slow evolution toward extreme mass ratio will cause them finally to coalesce to single stars. Therefore, both of them are AW UMa-type near-coalescent overcontact binary systems.

  4. The first photometric study of W UMa eclipsing binary OQ Dra

    NASA Astrophysics Data System (ADS)

    Heidarnia, R.; Ebadi, H.; Rooydargard, H.

    2016-11-01

    The present study is an analysis of V-band CCD observations of new W UMa contact binary OQ Dra. To carry out the analysis, Primary and secondary minimum were obtained and new epoch was calculated. The computed period of system was 0.33967 day. Light curve analysis was performed using Binary Maker 3 and PHOEBE that uses the latest Wilson-Devinney code. We obtained photometric mass ratio of qptm = 0.55. O'Connell effect also was seen in the fitted model. Finally, the best model was achieved by introducing 2 spots on each component.

  5. NY Serpentis: SU UMa-type nova in the period gap with diversity of normal outbursts

    NASA Astrophysics Data System (ADS)

    Pavlenko, Elena P.; Kato, Taichi; Antonyuk, Oksana I.; Ohshima, Tomohito; Hambsch, Franz-Josef; Antonyuk, Kirill A.; Sosnovskij, Aleksei A.; Baklanov, Alex V.; Shugarov, Sergey Yu.; Pit, Nikolaj V.; Nakata, Chikako; Masi, Gianluca; Nakajima, Kazuhiro; Maehara, Hiroyuki; Dubovsky, Pavol A.; Kudzej, Igor; Andreev, Maksim V.; Kuznyetsova, Yuliana G.; Vasiliskov, Kirill A.

    2014-12-01

    We present a photometric study of NY Ser, an in-the-gap SU UMa-type nova, in 2002 and 2013. We determined the duration of its superoutburst and the mean period of its superhump are 18 d and 0.10458 d, respectively. We detected in 2013 that NY Ser showed two distinct states separated by a superoutburst. A state of rather infrequent normal outbursts lasted at least 44 d before the superoutburst, and a state of frequent outbursts started immediately after the superoutburst and lasted at least 34 d. Unlike a typical SU UMa star with a bimodal distribution of outburst duration, NY Ser displayed a diversity of normal outbursts. In the state of infrequent outbursts, we detected a wide ˜ 12 d outburst accompanied by 0.098 d orbital modulation but without superhumps ever established in NY Ser. We classified this as a "wide normal outburst." The orbital period was dominant both in quiescence and during normal outbursts in this state. In the state of the most frequent normal outbursts, the 0.10465 d positive superhump period was dominant and coexisted with the orbital modulation. In 2002 we detected the normal outburst of "intermediate" 5-6 d duration that was also accompanied by orbital modulations.

  6. LONG-TERM PHOTOMETRIC ANALYSIS OF THE ACTIVE W UMa-TYPE SYSTEM TU BOOTIS

    SciTech Connect

    Coughlin, Jeffrey L.; Dale, Horace A. III; Williamon, Richard M.

    2008-09-15

    We present multicolor light curves for the W UMa-type eclipsing binary TU Boo for two epochs separated by 22 years. An analysis of the O - C diagram indicates the earlier observations took place right in the middle of a major period change, thus allowing for a unique study on mass transfer and period changes in this W UMa-type system. We compute model fits to our light curves, along with the only other published set, using the Wilson-Devinney program, and find temporally correlated changes in the size of the secondary component with anomalies in the O - C diagram. We investigate the cause of these changes and find support for the existence of rapid, large-scale mass transfer between the components. We postulate that this interaction allows them to maintain nearly equal surface temperatures despite having achieved only marginal contact. We also find support for the evolutionary scenario in which TU Boo has undergone a mass ratio reversal in the past, due to large-scale mass transfer so that what is presently the secondary component of TU Boo is in an advanced evolutionary state, oversized due to a helium-enriched core, with a total system age of {>=}10 Gyr.

  7. PhenUMA: a tool for integrating the biomedical relationships among genes and diseases.

    PubMed

    Rodríguez-López, Rocío; Reyes-Palomares, Armando; Sánchez-Jiménez, Francisca; Medina, Miguel Ángel

    2014-11-25

    Several types of genetic interactions in humans can be directly or indirectly associated with the causal effects of mutations. These interactions are usually based on their co-associations to biological processes, coexistence in cellular locations, coexpression in cell lines, physical interactions and so on. In addition, pathological processes can present similar phenotypes that have mutations either in the same genomic location or in different genomic regions. Therefore, integrative resources for all of these complex interactions can help us prioritize the relationships between genes and diseases that are most deserving to be studied by researchers and physicians. PhenUMA is a web application that displays biological networks using information from biomedical and biomolecular data repositories. One of its most innovative features is to combine the benefits of semantic similarity methods with the information taken from databases of genetic diseases and biological interactions. More specifically, this tool is useful in studying novel pathological relationships between functionally related genes, merging diseases into clusters that share specific phenotypes or finding diseases related to reported phenotypes. This framework builds, analyzes and visualizes networks based on both functional and phenotypic relationships. The integration of this information helps in the discovery of alternative pathological roles of genes, biological functions and diseases. PhenUMA represents an advancement toward the use of new technologies for genomics and personalized medicine.

  8. Effect of spin-orbit coupling on the actinide dioxides AnO2 (An=Th, Pa, U, Np, Pu, and Am): A screened hybrid density functional study

    NASA Astrophysics Data System (ADS)

    Wen, Xiao-Dong; Martin, Richard L.; Roy, Lindsay E.; Scuseria, Gustavo E.; Rudin, Sven P.; Batista, Enrique R.; McCleskey, Thomas M.; Scott, Brian L.; Bauer, Eve; Joyce, John J.; Durakiewicz, Tomasz

    2012-10-01

    We present a systematic comparison of the lattice structures, electronic density of states, and band gaps of actinide dioxides, AnO2 (An=Th, Pa, U, Np, Pu, and Am) predicted by the Heyd-Scuseria-Ernzerhof screened hybrid density functional (HSE) with the self-consistent inclusion of spin-orbit coupling (SOC). The computed HSE lattice constants and band gaps of AnO2 are in consistently good agreement with the available experimental data across the series, and differ little from earlier HSE results without SOC. ThO2 is a simple band insulator (f 0), while PaO2, UO2, and NpO2 are predicted to be Mott insulators. The remainders (PuO2 and AmO2) show considerable O2p/An5f mixing and are classified as charge-transfer insulators. We also compare our results for UO2, NpO2, and PuO2 with the PBE+U, self interaction correction (SIC), and dynamic mean-field theory (DMFT) many-body approximations.

  9. BVR photometric study of NSVS 2607629. A high mass-ratio W-type W UMa system

    NASA Astrophysics Data System (ADS)

    Gürol, Birol; Michel, Raul

    2017-02-01

    We present the results of our investigation of the geometrical and physical parameters of the W UMa-type binary system NSVS 2607629 based on CCD BVRc light curves and their analysis with the Wilson-Devinney code. New times of minima and light elements have been determined. We find that, as seen in eccentric systems, secondary minima do not occur at phase 0.5. According to our solution, the system is found to be a high mass-ratio W-type W UMa system. Combining our photometric solution with the emprical relation obtained for W UMa type systems by Dimitrov and Kjurkchieva (2015) we derive the masses and radii of the components of this eclipsing system as M1 = 0.44M⊙ , M2 = 0.73M⊙ , R1 = 0.57R⊙ and R2 = 0.71R⊙ . The evolutionary state of the system is also discussed.

  10. The Shadow of a Gnomon Along a Year: Routine Observations and Teaching of Apparent Motion of the Sun and the Four Seasons. (Spanish Title: La Sombra de un Gnomon lo Largo de un Año: Observaciones de Rutina y la Enseñanza del Movimiento Aparente del Sol y Las Cuatro Estaciones.) A Sombra de um Gnômon ao Longo de um Ano: Observações Rotineiras e o Ensino do Movimento Aparente do Sol E das Quatro Estações

    NASA Astrophysics Data System (ADS)

    Trogello, Anderson Giovani; Danhoni Neves, Marcos Cesar; de Carvalho Rutz da Silva, Sani

    2013-12-01

    , al solsticio de junio, al equinoccio de septiembre y al solsticio de diciembre. Además, se dictaron clases teóricas en la sala de aula. Estos métodos buscaron construir conceptos en torno al movimiento aparente del Sol y la sucesión de las estaciones. Teniendo en cuenta los resultados de las actividades se aplicó una evaluación cuyos datos demuestran la existencia de un aprendizaje deseado por los estudiantes en cuanto a: el reconocimiento de los puntos cardinales, la descripción del movimiento solar aparente y la aparición de las estaciones y su alternancia a partir de observaciones astronómicas visuales sin instrumentos. Muitas concepções alternativas são reconhecidas entre os diversos grupos de estudantes, em especial nos da educação básica. Dentre elas, o movimento aparente do Sol, por mais quotidiano que seja, proporciona variadas interpretações. Deste modo, observar e registrar o movimento dos astros na abóboda celeste é uma tarefa necessária ao ensino de Astronomia. O trabalho que ora se apresenta propõe a apresentação dos resultados da observação do movimento aparente do Sol por intermédio da marcação da sombra de um gnômon vertical por alunos de uma turma do sexto ano do ensino fundamental de uma escola do campo do Paraná. O projeto em si ocorreu em quatro etapas, em datas próximas do equinócio de março, do solstício de junho, do equinócio de setembro e do solstício de dezembro. Além disso, foram desenvolvidas aulas teóricas em sala de aula. Tais métodos buscaram construir conceitos em torno da movimentação aparente do Sol e da alternância das estações do ano. Diante dos resultados provenientes das atividades desenvolvidas foi aplicada uma avaliação e os dados demonstraram um aprendizado desejado dos alunos quanto: ao reconhecimento dos pontos cardeais; à descrição do movimento solar aparente e a ocorrência das estações do ano e sua alternância a partir de observações astronômicas a olho nu.

  11. Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. IV. The Fourth Year (2011-2012)

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Hambsch, Franz-Josef; Maehara, Hiroyuki; Masi, Gianluca; Miller, Ian; Noguchi, Ryo; Akasaka, Chihiro; Aoki, Tomoya; Kobayashi, Hiroshi; Matsumoto, Katsura; Nakagawa, Shinichi; Nakazato, Takuma; Nomoto, Takashi; Ogura, Kazuyuki; Ono, Rikako; Taniuchi, Keisuke; Stein, William; Henden, Arne; de Miguel, Enrique Kiyota, Seiichiro; Dubovsky, Pavol A.; Kudzej, Igor; Imamura, Kazuyoshi; Akazawa, Hidehiko; Takagi, Ryosuke; Wakabayashi, Yuya; Ogi, Minako; Tanabe, Kenji; Ulowetz, Joseph; Morelle, Etienne; Pickard, Roger D.; Ohshima, Tomohito; Kasai, Kiyoshi; Pavlenko, Elena P.; Antonyuk, Oksana I.; Baklanov, Aleksei V.; Antonyuk, Kirill; Samsonov, Denis; Pit, Nikolaj; Sosnovskij, Aleksei; Littlefield, Colin; Sabo, Richard; Ruiz, Javier; Krajci, Thomas; Dvorak, Shawn; Oksanen, Arto; Hirosawa, Kenji; Goff, William N.; Monard, Berto; Shears, Jeremy; Boyd, David; Voloshina, Irina B.; Shugarov, Sergey Yu.; Chochol, Drahomir; Miyashita, Atsushi; Pietz, Jochen; Katysheva, Natalia; Itoh, Hiroshi; Bolt, Greg; Andreev, Maksim V.; Parakhin, Nikolai; Malanushenko, Viktor; Martinelli, Fabio; Denisenko, Denis; Stockdale, Chris; Starr, Peter; Simonsen, Mike; Tristram, Paul J.; Fukui, Akihiko; Tordai, Tamas; Fidrich, Robert; Paxson, Kevin B.; Itagaki, Koh-ichi; Nakashima, Youichirou; Yoshida, Seiichi; Nishimura, Hideo; Kryachko, Timur V.; Samokhvalov, Andrey V.; Korotkiy, Stanislav A.; Satovski, Boris L.; Stubbings, Rod; Poyner, Gary; Muyllaert, Eddy; Gerke, Vladimir; MacDonald, Walter, II; Linnolt, Michael; Maeda, Yutaka; Hautecler, Hubert

    2013-02-01

    Continuing the project described by Kato et al. (2009, PASJ, 61, S395), we collected times of superhump maxima for 86 SU UMa-type dwarf novae, mainly observed during the 2011-2012 season. We confirmed general trends recorded in our previous studies, such as the relation between period derivatives and orbital periods. There are some systems showing positive period derivatives despite the long orbital period. We observed the 2011 outburst of the WZ Sge-type dwarf nova BW Scl, and recorded an O - C diagram similar to those of previously known WZ Sge-type dwarf novae. The WZ Sge-type dwarf nova OT J184228.1+483742 showed an unusual pattern of double outbursts composed of an outburst with early superhumps and one with ordinary superhumps. We propose an interpretation that a very small growth rate of the 3:1 resonance due to an extremely low mass-ratio led to quenching the superoutburst before the ordinary superhump appeared. We systematically studied ER UMa-type dwarf novae, and found that V1159 Ori showed positive superhumps similar to ER UMa in the 1990s. The recently recognized ER UMa-type object BK Lyn dominantly showed negative superhumps, and its behavior was very similar to the present-day state of ER UMa. The pattern of period variations in AM CVn-type objects was very similar to that of short-period hydrogen-rich SU UMa-type dwarf novae, making them a helium analogue of hydrogen-rich SU UMa-type dwarf novae. SBS 1108+574, a peculiar hydrogen-rich dwarf nova below the period minimum, showed a very similar pattern of period variations to those of short-period SU UMa-type dwarf novae. The mass-ratio derived from the detected orbital period suggests that this secondary is a somewhat evolved star whose hydrogen envelope was mostly stripped during the mass-exchange. CC Scl, MASTER OT J072948.66+593824.4, and OT J173516.9+154708 showed only low-amplitude superhumps with complex profiles. These superhumps are likely to be a combination of two closely separated periods.

  12. SU UMa dwarf novae in the period gap showing the negative superhumps

    NASA Astrophysics Data System (ADS)

    Pavlenko, Elena

    2016-07-01

    There are only two known up to date SU UMa dwarf novae in the period gap showing the negative superhumps, namely, MN Dra and 1RXS J003828.7+250920. We present the results of X-ray and spectral investigation for 1RXS J003828.7+250920, multicolor optical investigation for 1RXS J003828.7+250920 and MN Dra at different stages of their activity in 2011-2016 years. We discuss a finding of the accretion disc radius for both dwarf novae, its variation during separated intervals between outbursts for MN Dra as well as high and low temperature regions in quiescent accretion disk for 1RXS J003828.7+250920.

  13. Sonification of Kepler Field SU UMa Cataclysmic Variable Stars V344 Lyr and V1504 Cyg

    NASA Technical Reports Server (NTRS)

    Tutchton, Roxanne M.; Wood, Matt A.; Still, Martin D.; Howell, Steve B.; Cannizzo, John K.; Smale, Alan P.

    2012-01-01

    Sonification is the conversion of quantitative data into sound. In this work we explain the methods used in the sonification of light curves provided by the Kepler instrument from Q2 through Q6 for the cataclysmic variable systems V344 Lyr and V1504 Cyg . Both systems are SU UMa stars showing dwarf nova outbursts and superoutbursts as well as positive and negative superhumps. Focused sonifications were done from average pulse shapes of each superhump, and separate sonifications of the full, residual light curves were done for both stars. The audio of these data reflected distinct patterns within the evolutions of supercycles and superhumps that matched pervious observations and proved to be effective aids in data analysis.

  14. Orbital Period Investigations of Two W UMa-type Binaries: AH Aur and V728 Her

    NASA Astrophysics Data System (ADS)

    Yu, Yun-Xia; Xiang, Fu-Yuan; Hu, Ke

    2016-04-01

    The orbital period changes of two W UMa-type binaries, AH Aur and V728 Her, are investigated based on all available times of the light minimum taken from the databases and literature. It is revealed that the orbital period of AH Aur shows a long-term decrease at a rate of {dP}/{dt}=-2.491× {10}-7 days yr-1. For V728 Her, we find that the orbital period exhibits a secular increase at a rate of {dP}/{dt}=3.793× {10}-7 days yr-1. The secular period changes suggest that AH Aur and V728 Her are undergoing rapid mass transfer between the primary star and the secondary companion.

  15. Mapping of surface activity on the W UMa-type system VW Cephei

    NASA Technical Reports Server (NTRS)

    Bradstreet, David H.; Guinan, Edward F.

    1988-01-01

    After multifilter photometry of the W UMa-type contact binary VW Cep (P = 6.67 hr; G5V + K0V) in 1986/87 revealed large asymmetries in the light curves believed to be caused by large, cool starspot regions on the surface of the larger stars, in Apr. 1987 it was observed with IUE to study the chromospheres and transition regions of the components. During one complete orbital cycle, three SWP and four LWP low dispersion spectra were obtained, including and then excluding the suspected active region. Phase dependent TR line emission strengths were found, most notably C IV, which is 50 percent stronger when the spot region is most visible. The results could be important because VW Cep represents an extreme case for studying stellar dynamo theory and observations can play a crucial role in the unterstanding of magnetic fields and activity cycles in rapidly rotating solar-like stars.

  16. VizieR Online Data Catalog: Search for UMa group companions (Ammler-von Eiff+, 2016)

    NASA Astrophysics Data System (ADS)

    Ammler-von Eiff, M.; Bedalov, A.; Kranhold, C.; Mugrauer, M.; Schmidt, T. O. B.; Neuhaeuser, R.; Errmann, R.

    2016-03-01

    The astrometric and photometric data of companion candidates of members of the Ursa Major (UMa) group are presented. They were identified by coronagraphic observations obtained with the S27 camera of NACO at the ESO VLT, Chile, in 2003-2006. Most of the candidates were observed a second time to assess whether they share the proper motion of the star. For this purpose, the change in position with respect to the star was compared to the stellar parallactic and proper motion known from Hipparcos. This way, all candidates with two epochs of observations were rejected being distant background objects. The layout of the included table deviates from the article version to facilitate automatic reading, i.e. the epoch date and the primary name are added to each row, and the candidate identifier is added to the corresponding data set for each epoch. (2 data files).

  17. Multicolour high-speed photometry and Hα spectroscopy of XY UMa

    NASA Astrophysics Data System (ADS)

    Kjurkchieva, D.; Marchev, D.; Ogloza, W.

    2000-02-01

    BVRI photometry and Hα -line spectroscopy of the short-period RS CVn-binary XY UMa are presented. The light curves as a whole as well as the two eclipse minima are asymmetric. The light level after the primary minimum is lower by about 0.04-0.05 mag than that after the secondary one. Two cool spots on the primary with sizes 20degr and 10degr , temperatures 4630 and 4330 K at middle latitudes reproduced well the distortion curve in all colours. The observed Hα profile is quite wide and asymmetric at most the phases out of the eclipses. The radial velocity curve is sinusoidal with semiamplitude K1=120.7+/- 2.9 km/s. The corresponding mass function of the system is 0.082Msun . The phase behaviour of the Hα -profile implies contribution of emission of the chromospheric regions above the photospheric spots.

  18. Buckets of Ash Track Tephra Flux From Halema`uma`u Crater, Hawai`i

    NASA Astrophysics Data System (ADS)

    Swanson, Don; Wooten, Kelly; Orr, Tim

    2009-11-01

    The 2008-2009 eruption at Kīlauea Volcano's summit made news because of its eight small discrete explosive eruptions and noxious volcanic smog (vog) created from outgassing sulfur dioxide. Less appreciated is the ongoing, weak, but continuous output of tephra, primarily ash, from the new open vent in Halema`uma`u Crater. This tephra holds clues to processes causing the eruption and forming the new crater-in-a-crater, and its flux is important to hazard evaluations. The setting of the vent—easily accessible from the Hawaiian Volcano Observatory (HVO)—is unusually favorable for near-daily tracking of tephra mass flux during this small prolonged basaltic eruption. Recognizing this, scientists from HVO are collecting ash and documenting how ejection masses, components, and chemical compositions vary through time.

  19. VizieR Online Data Catalog: Mid-eclipse times of DV UMa (Han+, 2017)

    NASA Astrophysics Data System (ADS)

    Han, Z.-T.; Qian, S.-B.; Irina, V.; Zhu, L.-Y.

    2017-08-01

    New CCD photometric observations of DV UMa were carried out by using three different telescopes. Beginning on 2009 November 12, this star was continuously monitored with the 2.4m telescope at the Lijiang observational station of Yunnan Observatories (YNAO). To collect more data for this binary, an observation was made on 2016 March 29 with an Andor DW436 1K CCD camera mounted on the 85cm reflecting telescope at the XingLong station of the National Astronomical Observatory and another observation made on 2017 January 23 with an Andor DW936 2K CCD camera attached to the 1.0m reflecting telescope at YNAO. During the observations, no filters were used in order to improve the time resolution. (1 data file).

  20. Photometric and Period Investigation of the Late F-type Overcontact Binary II UMa

    NASA Astrophysics Data System (ADS)

    Zhou, X.; Qian, S.-B.; Zhang, J.; Zhang, B.; Kreiner, J.

    2016-03-01

    II UMa is a late F-type (F5) contact binary with a close-in tertiary and a distant visual companion. According to the four-color (B V RcIc) light curves’ solutions of II UMa, it is a high fill-out (f = 86.6%) and low-mass ratio (q = 0.172) contact binary system, which indicates that it is at the late evolutionary stage of late-type tidal-locked binary stars. The masses of the primary star and secondary star are calculated to be {M}1=1.99{M}⊙ and {M}2=0.34{M}⊙ . The primary star has evolved from the zero-age main sequence, but it still appeared before the terminal-age main sequence, and the secondary star is even more evolved. Considering the mass ratio ({M}3/{M}1=0.67) obtained by spectroscopic observations, the mass of the close-in tertiary is estimated to be {M}3=1.34{M}⊙ . The period variations of the binary system are investigated for the first time. According to the observed-calculated (O-C) curve analysis, a continuous period increase at a rate of {dP}/{dt}=4.88× {10}-7 {day} {{yr}}-1 is determined. The parabolic variation in the O-C curve may be part of a cyclic period of change, or the combined period of change of a parabolic variation and a cyclic one. More instances of minimum light are needed to confirm this. The presence of the tertiary component may play an important role in the formation and evolution of this binary system by drawing angular momentum from the central system during the pre-contact stage.

  1. Habitable Zones for Earth-Like Planets in the 47UMa Planetary System

    NASA Astrophysics Data System (ADS)

    Ji, Jianghui; Liu, Lin

    The Habitable zones are usually believed to be appropriate environment for terrestrial planets that can provide the liquid-water, subtle temperature, atmosphere components of CO2, H2O, and N2 [Kasting et al., Icarus 101 (1993) 108], supporting the development and biological evolution of life on their surfaces. In this work [see an accompanied paper, Ji et al., Astrophysical Journal 631 (2005) 1191 for details], we investigated the dynamical architecture of 47 UMa with the planetary configuration of the best-fit orbital solutions by Fischer et al. [Astrophysical Journal 586 (2003) 1394], to study the existence of the Earth-like planets in the region for 0.05 AU ≤ a ≤ 2.0 AU for 47 UMa by numerical simulations. In the study, we found that the “hot Earths” at 0.05 AU ≤ a ≤ 0.4 AU can dynamically survive at least for 1 Myr. The Earth-like planets can eventually remain in the system for 10 Myr at the areas involved in mean motion resonance (MMR) (e.g., 3:2 MMR and 9:5 MMR) with the inner companion. Moreover, we showed that the 2:1 and 3:1 resonances could be marginally stable, but the 5:2 MMR is unstable. In a dynamical sense, we point out that the most possible candidate habitable environment is that the Earth-like planets may bear the orbits of 0.8 AU ≤ a ≤ 1.0 AU and 1.0 AU ≤ a ≤ 1.30 AU (except 5:2 MMR) for relatively lower eccentricities. We also conducted similar studies in other multi-planet systems and found the potential existence of the Earth-like planets in habitable zones.

  2. THE LEECH EXOPLANET IMAGING SURVEY: ORBIT AND COMPONENT MASSES OF THE INTERMEDIATE-AGE, LATE-TYPE BINARY NO UMa

    SciTech Connect

    Schlieder, Joshua E.; Skemer, Andrew J.; Hinz, Philip; Leisenring, Jarron; Defrère, Denis; Close, Laird M.; Eisner, Josh A.; Maire, Anne-Lise; Desidera, Silvano; Skrutskie, Michael F.; Bailey, Vanessa; Esposito, Simone; Strassmeier, Klaus G.; Weber, Michael; Biller, Beth A.; Bonnefoy, Mickaël; Buenzli, Esther; Henning, Thomas; Crepp, Justin R.; Hofmann, Karl-Heinz; and others

    2016-02-10

    We present high-resolution Large Binocular Telescope LBTI/LMIRcam images of the spectroscopic and astrometric binary NO UMa obtained as part of the LBT Interferometer Exozodi Exoplanet Common Hunt exoplanet imaging survey. Our H-, K{sub s}-, and L′-band observations resolve the system at angular separations <0.″09. The components exhibit significant orbital motion over a span of ∼7 months. We combine our imaging data with archival images, published speckle interferometry measurements, and existing spectroscopic velocity data to solve the full orbital solution and estimate component masses. The masses of the K2.0 ± 0.5 primary and K6.5 ± 0.5 secondary are 0.83 ± 0.02 M{sub ⊙} and 0.64 ± 0.02 M{sub ⊙}, respectively. We also derive a system distance of d = 25.87 ± 0.02 pc and revise the Galactic kinematics of NO UMa. Our revised Galactic kinematics confirm NO UMa as a nuclear member of the ∼500 Myr old Ursa Major moving group, and it is thus a mass and age benchmark. We compare the masses of the NO UMa binary components to those predicted by five sets of stellar evolution models at the age of the Ursa Major group. We find excellent agreement between our measured masses and model predictions with little systematic scatter between the models. NO UMa joins the short list of nearby, bright, late-type binaries having known ages and fully characterized orbits.

  3. Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. II The Second Year (2009-2010)

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Maehara, Hiroyuki; Uemura, Makoto; Henden, Arne; Miguel, Enrique De; Miller, Ian; Dubovsky, Pavol A.; Kudzej, Igor; Kiyota, Seiichiro; Hambsch, Franz-Josef; Tanabe, Kenji; Imamura, Kazuyoshi; Kunitomi, Nanae; Takagi, Ryosuke; Nose, Mikiha; Akazawa, Hidehiko; Masi, Gianluca; Nakagawa, Shinichi; Iino, Eriko; Noguchi, Ryo; Matsumoto, Katsura; Fujii, Daichi; Kobayashi, Hiroshi; Ogura, Kazuyuki; Ohtomo, Sachi; Yamashita, Kousei; Yanagisawa, Hirofumi; Itoh, Hiroshi; Bolt, Greg; Monard, Berto; Ohshima, Tomohito; Shears, Jeremy; Ruiz, Javier; Imada, Akira; Oksanen, Arto; Nelson, Peter; Gomez, Tomas L.; Staels, Bart; Boyd, David; Voloshina, Irina B.; Krajci, Thomas; Crawford, Tim; Stockdale, Chris; Richmond, Michael; Morelle, Etienne; Novák, Rudolf; Nogami, Daisaku; Ishioka, Ryoko; Brady, Steve; Simonsen, Mike; Pavlenko, Elena P.; Ringwald, Frederick A.; Kuramoto, Tetsuya; Miyashita, Atsushi; Pickard, Roger D.; Hynek, Tomáš; Dvorak, Shawn; Stubbings, Rod; Muyllaert, Eddy

    2010-12-01

    Continued from Kato et al. (2009, PASJ, 61, S395), we collected the times of superhump maxima for 68 SU UMa-type dwarf novae, mainly observed during the 2009-2010 season. The newly obtained data confirmed the basic findings reported in Kato et al. (ibid.): the presence of stages A-C and the predominance of positive period derivatives during stage B in systems with superhump periods shorter than 0.07 d. There was a systematic difference in the period derivatives for the systems with superhump periods longer than 0.075 d between this study and Kato et al. (ibid.). We suggest that this difference was possibly caused by a relative lack of frequently outbursting SU UMa-type dwarf novae in this period regime in the present study. We recorded a strong beat phenomenon during the 2009 superoutburst of IY UMa. A close correlation between the beat period and the superhump period suggests that the changing angular velocity of the apsidal motion of the elliptical disk is responsible for the variation of the superhump periods. We also described three new WZ Sge-type objects with established early superhumps and one with likely early superhumps. We suggest that two systems, VX For and EL UMa, are WZ Sge-type dwarf novae with multiple rebrightenings. The O - C variation in OT J213806.6+261957 suggests that the frequent absence of rebrightenings in very short-Porb objects can be the result of a sustained superoutburst plateau at the epoch when usual SU UMa-type dwarf novae return to quiescence, preceding a rebrightening. We also present a formulation for a variety of Bayesian extensions to traditional period analyses.

  4. The LEECH Exoplanet Imaging Survey: Orbit and Component Masses of the Intermediate-Age, Late-Type Binary NO UMa

    NASA Astrophysics Data System (ADS)

    Schlieder, Joshua E.; Skemer, Andrew J.; Maire, Anne-Lise; Desidera, Silvano; Hinz, Philip; Skrutskie, Michael F.; Leisenring, Jarron; Bailey, Vanessa; Defrère, Denis; Esposito, Simone; Strassmeier, Klaus G.; Weber, Michael; Biller, Beth A.; Bonnefoy, Mickaël; Buenzli, Esther; Close, Laird M.; Crepp, Justin R.; Eisner, Josh A.; Hofmann, Karl-Heinz; Henning, Thomas; Morzinski, Katie M.; Schertl, Dieter; Weigelt, Gerd; Woodward, Charles E.

    2016-02-01

    We present high-resolution Large Binocular Telescope LBTI/LMIRcam images of the spectroscopic and astrometric binary NO UMa obtained as part of the LBT Interferometer Exozodi Exoplanet Common Hunt exoplanet imaging survey. Our H-, Ks-, and L‧-band observations resolve the system at angular separations <0.″09. The components exhibit significant orbital motion over a span of ∼7 months. We combine our imaging data with archival images, published speckle interferometry measurements, and existing spectroscopic velocity data to solve the full orbital solution and estimate component masses. The masses of the K2.0 ± 0.5 primary and K6.5 ± 0.5 secondary are 0.83 ± 0.02 M⊙ and 0.64 ± 0.02 M⊙, respectively. We also derive a system distance of d = 25.87 ± 0.02 pc and revise the Galactic kinematics of NO UMa. Our revised Galactic kinematics confirm NO UMa as a nuclear member of the ∼500 Myr old Ursa Major moving group, and it is thus a mass and age benchmark. We compare the masses of the NO UMa binary components to those predicted by five sets of stellar evolution models at the age of the Ursa Major group. We find excellent agreement between our measured masses and model predictions with little systematic scatter between the models. NO UMa joins the short list of nearby, bright, late-type binaries having known ages and fully characterized orbits. Based on data obtained with the STELLA robotic telescope in Tenerife, an AIP facility jointly operated by AIP and IAC.

  5. Difficulties of First Years Elementary School Teachers with the Teaching of Astronomy. (Breton Title: Dificuldades de Professores dos Anos Iniciais do Ensino Fundamental em Relação ao Ensino da Astronomia. ) Dificultades de LOS Profesores de los Primeros Años de la Escuela Primaria en Relación a la Enseñanza de la Astronomía

    NASA Astrophysics Data System (ADS)

    Langhi, Rodolfo; Nardi, Roberto

    2005-12-01

    This paper reports Primary School teachers' discourses analysis about their difficulties related to the teaching of Astronomy. It reports partial data of a master's level research carried out in the last two years, named "An exploratory study for inserting Astronomy in primary school teachers' education" (LANGHI, 2004). The study took into consideration students' and teachers' common sense conceptions about astronomical phenomena, conceptual mistakes in textbooks, and Astronomy's suggestions given by the PCN (Parâmetros Curriculares Nacionais - The Brazilian National Curriculum Standards). The paper aims to characterize teachers' difficulties, in order to provide subsides to the implementation of an initial or continuing education program. This study is justified by the fact that courses plans like these only will be adapted to the teacher's (and students') reality, if there is a primary investigation about what the teachers really need to know about Astronomy. This fact was possible here by the enunciations interpretation of a teachers' sample using semi-structured interviews, according to discourse analysis procedures. The research outcomes show difficulties related to factors like: those of personal order, methodological, on teacher's formation, educational infrastructure and other related to information sources for educators. Este artigo, que relata as dificuldades de professores em relação ao ensino da Astronomia, faz parte de um estudo exploratório para a inserção da Astronomia na formação de professores dos anos iniciais do Ensino Fundamental. Esse estudo leva em consideração as concepções alternativas de alunos e professores sobre fenômenos astronômicos, os erros conceituais em livros didáticos e as sugestões de conteúdos de Astronomia constantes nos PCN (Parâmetros Curriculares Nacionais). Caracterizar as dificuldades dos professores é a questão central deste texto, apontando para o objetivo de contribuir com subsídios para um futuro

  6. JH and K-band spectra of three SU UMa-type Dwarf Novae

    NASA Astrophysics Data System (ADS)

    Ishioka, R.; Sekiguchi, K.; Maehara, H.

    2007-08-01

    We present the results of JH and K-band spectroscopy on three SU UMa-type dwarf novae with orbital periods of 1.33 ~1.37 hr. We performed the SED fitting for the obtained spectra by assuming a power law distribution for the accretion disk and using template spectra of late-type dwarfs for secondary star. ASAS 002511+1217.2 and EQ J183926+260409 are WZ Sge-type or WX Cet-type dwarf novae. We found strong water absorption features in their spectra, which are characteristic in late M- or L-type dwarfs. The SED fitting suggests that their secondary contributions to the overall SED are less than one third. We identified the secondary stars as M9 and L1 type dwarfs, which are rather less massive but still normal stars. The spectrum of SDSS J013701-091235 is dominated by the secondary component. Spectral features of this object are similar to those of an early M-type dwarf in spite of its short orbital period. The spectrum of SDSS0137 strongly suggests that the evolutionary path of this object is different from that of ordinary CVs, and this object is a candidate of EI Psc-like systems.

  7. Implementation of UMA concept in advanced Internet environments using MPEG-21

    NASA Astrophysics Data System (ADS)

    Rovira, Marc; Freixes, Marc; Lopez, Alejandro; Fernandez, Gabriel

    2005-10-01

    This work presents a partial development within the Internet2 Catalan project called "Integrated Project" which aims to design and build an advanced Internet environment based on Universal Multimedia Access (UMA) concept using MPEG-21 standard tools in order to enable transparent and augmented use of multimedia content across a wide range of networks, devices and by different users. The project is integrated with several modules using Web Service architecture in an interoperable manner to accomplish a complete distributed system. Within this framework, the DI Management & Personalization module provides services such as content recommendation, advanced searches, best content adaptation possibilities and session mobility management. By means of cataloguing tools, user preferences setting and update according to user's habit consumption, it offers content recommendations taking also into account user preferences, terminal capabilities, and network characteristics. Finally, during the consumption process, the Adaptation Decision Engine selects the best adaptation process in each case taking into account network characteristics, terminal capabilities, and state of AV content transcoding servers. The module provides extensive use of MPEG-21 and MPEG-7 standards ensuring interoperability with other similar systems.

  8. An Orbital Period Study of the W UMa-Type Binary RZ Comae Berenicis

    NASA Astrophysics Data System (ADS)

    Qian, Sheng-Bang; He, Jia-Jia

    2005-12-01

    New photoelectric and CCD photometry observations of a short-period W UMa-type binary system, RZ Com, are presented. The light curves of Broglia (1960, Contr. Milano-Merate, 165) were symmetric in V band, while the present light curve shows a typical O'Connell effect, with Maximum I brighter than Maximum II by 0.015mag. It is found that the light curve of the binary star has changed from W-subtype to A-subtype according to Binnendijk's classification. This variation may be caused by the activity of dark spot on the primary component. Combining four newly determined times of the light minimum with others published in the literature, the orbital period change of the system was investigated. A small-amplitude oscillation (A = 0.0058 d), with a period of 44.8yr has been discovered to be superimposed on a long-term period increase with a rate of dP/dt = +4.12 × 10-8 d yr-1. The period oscillation can be explained either by the light-time effect via the presence of an unseen third body or by magnetic-activity cycles of the components. The mass ratio of RZ Com is q = 0.43. The secular period variation is in agreement with the conclusions of Qian (2001, MNRAS, 328, 914; 2003, MNRAS, 342, 1260). This indicates that it is on the TRO-controlled stage of the evolutionary scheme proposed by Qian.

  9. Absolute-magnitude Calibration for W UMa-type Systems Based on Gaia Data

    NASA Astrophysics Data System (ADS)

    Mateo, Nicole M.; Rucinski, Slavek M.

    2017-09-01

    Tycho-Gaia Astrometric Solution (TGAS) parallax data are used to determine absolute magnitudes M V for 318 W UMa-type (EW) contact binary stars. A very steep (slope ≃ ‑9), single-parameter ({log}P), linear calibration can be used to predict M V to about 0.1–0.3 mag over the whole range of accessible orbital period, 0.22< P< 0.88 days. A similar calibration for the most common systems with 0.275< P< 0.575 days predicts M V values to about 0.06–0.16 mag. For orbital period values both shorter and longer than the central range, the period dependence is respectively steeper and shallower, i.e., the binaries are fainter in M V than predicted by the whole-range linear law. The steepness of the relation for short-period systems implies important consequences for the detectability of the faintest binaries, defining the short-period cut-off of the period distribution. Although the scatter around the linear {log}P-fit is fairly large (0.2–0.4 mag), the current data do not support the inclusion of a B-V color term in the calibration. ). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement.

  10. Observations and light curve solutions of six deep-contact W UMa binaries

    NASA Astrophysics Data System (ADS)

    Kjurkchieva, D. P.; Popov, V. A.; Vasileva, D. L.; Petrov, N. I.

    2017-10-01

    This work presents photometric observations of the W UMa binaries V0637 Peg. V0473 Cam, CSS J153314.8+560527, CSS J075258.0+382035, V0416 Gem and NSVS 6859986, made using Sloan g' and i'$ filters. The periods of these binaries are in the range of 0.26-0.43 d. The light curve solutions revealed that the components of each binary system are almost equal in temperature. The stellar components are of G and K spectral types and undergo total eclipses. All observation targets have deep-contact configurations with a fill-out factor of f≥0.5. NSVS 6859986 has one of the highest fill-out factors that have been determined, f=0.84. We studied the empirical dependencies between the fill-out factor and the stellar parameters (temperature, period, mass ratio, relative component radii, and luminosity ratio) in a sample of around thirty stars; they are consistent with theoretical predictions, although there are deviations from the main tendencies.

  11. Phenomenological Parameters of the Prototype Eclipsing Binaries Algol, β Lyrae and W UMa

    NASA Astrophysics Data System (ADS)

    Tkachenko, Mariia G.; Andronov, Ivan L.; Chinarova, Lidia L.

    2016-12-01

    The phenomenological parameters of eclipsing binary stars, which are the prototypes of the EA, EB and EW systems are determined using the expert complex of computer programs, which realizes the NAV ("New Algol Variable") algorithm (Andronov 2010, 2012) and its possible modifications are discussed, as well as constrains for estimates of some physical parameters of the systems in a case of photometric observations only, such as the degree of eclipse, ratio of the mean surface brightnesses of the components. The half-duration of the eclipse is 0.0617(7), 0.1092(18) and 0.1015(7) for Algol, β Lyrae and W UMa, respectively. The brightness ratio is 6.8±1.0, 4.9±1.0 and 1.15±0.13. These results show that the eclipses have distinct begin and end not only in EA (as generally assumed), but also in EB and EW - type systems as well. The algorithm may be applied to classification and study of the newly discovered (or poorly studied) eclipsing variables based on own observations or that obtained using photometric surveys.

  12. Curious Variables Experiment (CURVE). RZ LMi - the Most Active SU UMa Star

    NASA Astrophysics Data System (ADS)

    Olech, A.; Wisniewski, M.; Zloczewski, K.; Cook, L. M.; Mularczyk, K.; Kedzierski, P.

    2008-06-01

    We report extensive photometry of the frequently outbursting dwarf nova RZ Leo Minoris. During two seasons of observations we detected 12 superoutbursts and 7 normal outbursts. The V magnitude of the star varied in range from 16.5 mag to 13.9 mag. The superoutbursts occur quite regularly flashing every 19.07(4) days and lasting slightly over 10 days. The average interval between two successive normal outbursts is 4.027(3) days. The mean superhump period observed during the superoutbursts is P_sh=0.059396(4) days (85.530+/-0.006 min). The period of the superhumps was constant except for one superoutburst when it increased with a rate of dot P/P_sh=7.6(1.9)x10^-5. Our observations indicate that RZ LMi enters the stage of permanent superhumps, both in superoutbursts and quiescence. This may indicate that decoupling of thermal and tidal instabilities play important role in ER UMa systems. No periodic light variations which can be connected with orbital period of the binary were seen, thus the mass ratio and evolutionary status of RZ LMi are still unknown.

  13. VizieR Online Data Catalog: HD 163151: a new W UMa type system (Rodriguez+ 1998)

    NASA Astrophysics Data System (ADS)

    Rodríguez, E.; Claret, A.; García, J. M.; Zerbi, F. M.; Garrido, R.; Martín, S.; Akan, C.; Luedeke, K.; Keskin, V.; Ibanoglu, C.; Evren, S.; Tunca, Z.; Pekunlu, R.; Paparo, M.; Nuspl, J.; Krisciunas, K.; Jiang, S. Y.

    1998-06-01

    Table 2 contains 408 simultaneous measurements collected in each of the four uvby colours of the Stromgren photometric system for the W UMa system HD 163151. The data are magnitude differences (Du, Dv, Db, Dy, D(b-y), Dm1, Dc1) of the variable star minus comparison star in the standard system versus Heliocentric Julian Day. Tables 3, 4 and 5 are the same, but for Hβ (65 points), Johnson B data (212 points) and Johnson V data (355 points). The comparison star is HD 166095. The origin in time is the Julian Day 2449858. The observations were carried out (by E. Rodriguez, A. Claret, J.M. Garcia, F.M. Zerbi, R. Garrido, S. Martin, C. Akan, K. Luedeke, V. Keskin, C. Ibanoglu, S. Evren, Z. Tunca, R. Pekunlu, M. Paparo, J. Nuspl, K. Krisciunas and S.Y. Jiang) in 1995 during the course of a multisite campaign. The following telescopes were used: 90cm telescope of the Sierra Nevada Observatory, Spain (uvby-Hβ photometry); 50cm telescope at the Ege University Observatory, Turkey (BV-uvby); 50cm telescope at Piszkesteto mountain station, Konkoly Observatory, Hungary (BV); 50cm telescope at the Merate Observatory, Italy (V); 30cm telescope at Albuquerque, New Mexico, USA (V) and 15cm telescope at Mauna Kea, Hawaii, USA (V). (4 data files).

  14. The Effect of Blowsand Reduction on the Abundance of the Fringe-Toed Lizard (Uma inornata) in the Coachella Valley, California,

    DTIC Science & Technology

    1981-10-01

    dunes" (England and Nelson 1976). In fact, Plot 1 included one of the study areas used by England and Nelson. Both Norris (1958) and Pough (1970) have...inhibit burrowing by Uma (Norris 1958, Pough 1970), these measures were of little use in understanding the densities of Uma in Plots 1-9. In fact, when...situations (Stebbins 1944, Norris 1958) but some of Pough’s (1970) observations are at odds with these earlier ideas. Pough observed that Uma retreated at

  15. Backyard Research on Cataclysmic Variables by a Consortium of Professional and Amateur Astronomers: DV UMa-A Case Study

    NASA Astrophysics Data System (ADS)

    Vanmunster, T.

    2006-06-01

    The Center for Backyard Astrophysics (CBA) is a multi-longitude network of small photometric telescopes, owned by talented amateurs, who study periodic phenomena in Cataclysmic Variables (CVs). The CBA is among the leading examples of successful partnerships between professional and amateur enthusiasts, producing vast amounts of high-quality variable star data. This poster paper highlights observational CBA results obtained on DV UMa, a most interesting eclipsing UGSU-type dwarf nova, that has been intensively monitored during its April 1997 superoutburst.

  16. Survey of period variations of superhumps in SU UMa-type dwarf novae. V. The fifth year (2012-2013)

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Hambsch, Franz-Josef; Maehara, Hiroyuki; Masi, Gianluca; Nocentini, Francesca; Dubovsky, Pavol A.; Kudzej, Igor; Imamura, Kazuyoshi; Ogi, Minako; Tanabe, Kenji; Akazawa, Hidehiko; Krajci, Thomas; Miller, Ian; de Miguel, Enrique; Henden, Arne; Noguchi, Ryo; Ishibashi, Takehiro; Ono, Rikako; Kawabata, Miho; Kobayashi, Hiroshi; Sakai, Daisuke; Nishino, Hirochika; Furukawa, Hisami; Masumoto, Kazunari; Matsumoto, Katsura; Littlefield, Colin; Ohshima, Tomohito; Nakata, Chikako; Honda, Satoshi; Kinugasa, Kenzo; Hashimoto, Osamu; Stein, William; Pickard, Roger D.; Kiyota, Seiichiro; Pavlenko, Elena P.; Antonyuk, Oksana I.; Baklanov, Aleksei V.; Antonyuk, Kirill; Samsonov, Denis; Pit, Nikolaj; Sosnovskij, Aleksei; Oksanen, Arto; Harlingten, Caisey; Tyyskä, Jenni; Monard, Berto; Shugarov, Sergey Yu.; Chochol, Drahomir; Kasai, Kiyoshi; Maeda, Yutaka; Hirosawa, Kenji; Itoh, Hiroshi; Sabo, Richard; Ulowetz, Joseph; Morelle, Etienne; Michel, Raúl; Suárez, Genaro; James, Nick; Dvorak, Shawn; Voloshina, Irina B.; Richmond, Michael; Staels, Bart; Boyd, David; Andreev, Maksim V.; Parakhin, Nikolai; Katysheva, Natalia; Miyashita, Atsushi; Nakajima, Kazuhiro; Bolt, Greg; Padovan, Stefano; Nelson, Peter; Starkey, Donn R.; Buczynski, Denis; Starr, Peter; Goff, William N.; Denisenko, Denis; Kochanek, Christopher S.; Shappee, Benjamin; Stanek, Krzysztof Z.; Prieto, José L.; Itagaki, Koh-ichi; Kaneko, Shizuo; Stubbings, Rod; Muyllaert, Eddy; Shears, Jeremy; Schmeer, Patrick; Poyner, Gary; Rodríguez-Marco, Miguel

    2014-04-01

    Continuing the project described in Kato et al. (2009, PASJ, 61, S395), we collected times of superhump maxima for SU UMa-type dwarf novae mainly observed during the 2012-2013 season. We found three objects (V444 Peg, CSS J203937, and MASTER J212624) having strongly positive period derivatives despite the long orbital period (Porb). By using the period of growing stage (stage A) superhumps, we obtained mass ratios for six objects. We characterized nine new WZ Sge-type dwarf novae. We made a pilot survey of the decline rate in the slowly fading parts of SU UMa-type and WZ Sge-type outbursts. The decline time scale was found to generally follow an expected P_orb^{1/4} dependence, and WZ Sge-type outbursts also generally follow this trend. There are some objects which show slower decline rates, and we consider these objects good candidates for period bouncers. We also studied unusual behavior in some objects, including BK Lyn which made a transition from an ER UMa-type state to a novalike (standstill) state in 2013, and unusually frequent occurrences of superoutbursts in NY Ser and CR Boo. We applied the least absolute shrinkage and selection operator (Lasso) power spectral analysis, which has been proven to be very effective in analyzing the Kepler data, to the ground-based photometry of BK Lyn, and detected a dramatic disappearance of the signal of negative superhumps in 2013. We suggested that the mass-transfer rates did not strongly vary between the ER UMa-type state and novalike state in BK Lyn, and this transition was less likely caused by a systematic variation of the mass-transfer rate.

  17. THE FIRST PHOTOMETRIC INVESTIGATION OF THE NEGLECTED W-UMa-TYPE BINARY STAR UZ CMi

    SciTech Connect

    Qian, S.-B.; Li, K.; Liao, W.-P.; Liu, L.; Zhu, L.-Y.; He, J.-J.; Wang, J.-J.; Zhao, E.-G.

    2013-04-15

    UZ CMi was a W-UMa-type binary star found more than 80 years ago. However, it has been neglected in photometric investigations. Here, the first complete light curves in the B, V, R, and I bands are presented and analyzed using the Wilson and Devinney method. It is discovered that UZ CMi is a contact binary (f = 38.4({+-} 2.3)%) with a mass ratio of 0.45. The derived orbital inclination (i = 87 Degree-Sign ) indicates that it is a total eclipsing binary, which suggests that the determined parameters are reliable. By using 17 new eclipse times together with those collected from the literature, we found that the general trend of the observed-calculated (O - C) curve shows an upward parabolic variation that corresponds to a long-term increase in the orbital period at a rate of P-dot = +4.1 x 10{sup -8} days yr{sup -1}. The continuous increase may be caused by a mass transfer from the less massive component to the more massive one. This suggests that UZ CMi is in the thermal relaxation oscillation controlled stage of the evolutionary scheme proposed by Qian. UZ CMi will oscillate around a critical mass ratio and the contact configuration cannot be broken. After the upward parabolic change was removed, the (O - C){sub 2} curve of the photoelectric and charge-coupled device data revealed a cyclic variation with a small amplitude of 0.0026 days and a period of 21.1 yr. The cyclic change was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

  18. Infrasonic harmonic tremor and degassing bursts from Halema'uma'u Crater, Kilauea Volcano, Hawaii

    USGS Publications Warehouse

    Fee, David; Garcés, Milton; Patrick, Matt; Chouet, Bernard; Dawson, Phil; Swanson, Donald A.

    2010-01-01

    The formation, evolution, collapse, and subsequent resurrection of a vent within Halema'uma'u Crater, Kilauea Volcano, produced energetic and varied degassing signals recorded by a nearby infrasound array between 2008 and early 2009. After 25 years of quiescence, a vent-clearing explosive burst on 19 March 2008 produced a clear, complex acoustic signal. Near-continuous harmonic infrasonic tremor followed this burst until 4 December 2008, when a period of decreased degassing occurred. The tremor spectra suggest volume oscillation and reverberation of a shallow gas-filled cavity beneath the vent. The dominant tremor peak can be sustained through Helmholtz oscillations of the cavity, while the secondary tremor peak and overtones are interpreted assuming acoustic resonance. The dominant tremor frequency matches the oscillation frequency of the gas emanating from the vent observed by video. Tremor spectra and power are also correlated with cavity geometry and dynamics, with the cavity depth estimated at ~219 m and volume ~3 x 106 m3 in November 2008. Over 21 varied degassing bursts were observed with extended burst durations and frequency content consistent with a transient release of gas exciting the cavity into resonance. Correlation of infrasound with seismicity suggests an open system connecting the atmosphere to the seismic excitation process at depth. Numerous degassing bursts produced very long period (0.03-0.1 Hz) infrasound, the first recorded at Kilauea, indicative of long-duration atmospheric accelerations. Kilauea infrasound appears controlled by the exsolution of gas from the magma, and the interaction of this gas with the conduits and cavities confining it.

  19. Photometric Analysis of the Recently Discovered W UMa Star NR Camelopardalis: Period Change and Spot Migration

    NASA Astrophysics Data System (ADS)

    Shoup, Jenae; Reed, Phillip A.; Joner, Michael D.; Jensen, Eric L. N.; Collins, Karen A; Pepper, Joshua

    2014-06-01

    NR Cam is a short period (P=0.26 days) eclipsing binary of the W UMa type that was relatively recently discovered in the ROTSE1 data of the Northern Sky Variability Survey (NSVS) and was originally listed in the New Catalog of Suspected Variable Stars (NSV) with the identifier NSV 3754. Here we present the first known detailed study of NR Cam, which includes multi-band light curves, color curves, and a photometric orbital solution. NR Cam exhibits a strong O'Connell effect that can be attributed to magnetically induced spot activity on one of the components. Absolute photometry was performed in B and V at the Kutztown University Observatory in 2013 October and November and complementary high precision differential light curves were obtained in BVRI at the same time, as part of the KELT follow-up network, at Brigham Young University's West Mountain Observatory, Swarthmore College's Peter Van de Kamp Observatory, and the University of Louisville's Moore Observatory. After the B-V color curves were used to approximate the stellar surface temperatures and spot locations, the Wilson-Devinney code was employed with a differential corrections routine to determine the most likely stellar properties and orbital parameters. Our solution indicates that the two stars are in contact, sharing a common envelope, and their surface temperatures are approximately 4500 K and 4200 K. The inclination of the orbit was determined to be 68.0 (±0.6) degrees. When compared with the NSVS data, we find that the orbital period of NR Cam has changed over the past decade and that the strength of the O'Connell effect, and the associated spot activity, has also varied significantly.

  20. Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Imada, Akira; Uemura, Makoto; Nogami, Daisaku; Maehara, Hiroyuki; Ishioka, Ryoko; Baba, Hajime; Matsumoto, Katsura; Iwamatsu, Hidetoshi; Kubota, Kaori; Sugiyasu, Kei; Soejima, Yuichi; Moritani, Yuuki; Ohshima, Tomohito; Ohashi, Hiroyuki; Tanaka, Junpei; Sasada, Mahito; Arai, Akira; Nakajima, Kazuhiro; Kiyota, Seiichiro; Tanabe, Kenji; Imamura, Kazuyoshi; Kunitomi, Nanae; Kunihiro, Kenji; Taguchi, Hiroki; Koizumi, Mitsuo; Yamada, Norimi; Nishi, Yuichi; Kida, Mayumi; Tanaka, Sawa; Ueoka, Rie; Yasui, Hideki; Maruoka, Koichi; Henden, Arne; Oksanen, Arto; Moilanen, Marko; Tikkanen, Petri; Aho, Mika; Monard, Berto; Itoh, Hiroshi; Dubovsky, Pavol A.; Kudzej, Igor; Dancikova, Radka; Vanmunster, Tonny; Pietz, Jochen; Bolt, Greg; Boyd, David; Nelson, Peter; Krajci, Thomas; Cook, Lewis M.; Torii, Ken'ichi; Starkey, Donn R.; Shears, Jeremy; Jensen, Lasse-Teist; Masi, Gianluca; Hynek, Tomáš; Nová; K, Rudolf; Kociá; N, Radek; Krá; L, Lukáš; Kučá; Ková, Hana; Kolasa, Marek; Štastný, Petr; Staels, Bart; Miller, Ian; Sano, Yasuo; de Ponthière, Pierre; Miyashita, Atsushi; Crawford, Tim; Brady, Steve; Santallo, Roland; Richards, Tom; Martin, Brian; Buczynski, Denis; Richmond, Michael; Kern, Jim; Davis, Stacey; Crabtree, Dustin; Beaulieu, Kevin; Davis, Tracy; Aggleton, Matt; Morelle, Etienne; Pavlenko, Elena P.; Andreev, Maksim; Baklanov, Alexander; Koppelman, Michael D.; Billings, Gary; Urbancok, L'ubomír; Ögmen, Yenal; Heathcote, Bernard; Gomez, Tomas L.; Voloshina, Irina; Retter, Alon; Mularczyk, Krzysztof; Zoczewski, Kamil; Olech, Arkadiasz; Kedzierski, Piotr; Pickard, Roger D.; Stockdale, Chris; Virtanen, Jani; Morikawa, Koichi; Hambsch, Franz-Josef; Garradd, Gordon; Gualdoni, Carlo; Geary, Keith; Omodaka, Toshihiro; Sakai, Nobuyuki; Michel, Raul; Cárdenas, A. A.; Gazeas, Kosmas D.; Niarchos, Panos G.; Yushchenko, Alexander V.; Mallia, Franco; Fiaschi, Marco; Good, Gerry A.; Walker, Stan; James, Nick; Douzu, Ken-Ichi; Julian, Wm Mack, II; Butterworth, Neil D.; Shugarov, Sergey Yu.; Volkov, Igor; Chochol, Drahomir; Katysheva, Natalia; Rosenbush, Alexander E.; Khramtsova, Maria; Kehusmaa, Petri; Reszelski, Maciej; Bedient, James; Liller, William; Pojmanski, Grzegorz; Simonsen, Mike; Stubbings, Rod; Schmeer, Patrick; Muyllaert, Eddy; Kinnunen, Timo; Poyner, Gary; Ripero, Jose; Kriebel, Wolfgang

    2009-12-01

    We systematically surveyed period variations of superhumps in SU UMa-type dwarf novae based on newly obtained data and past publications. In many systems, the evolution of the superhump period is found to be composed of three distinct stages: an early evolutionary stage with a longer superhump period, a middle stage with systematically varying periods, and a final stage with a shorter, stable superhump period. During the middle stage, many systems with superhump periods of less than 0.08 d show positive period derivatives. We present observational characteristics of these stages and give greatly improved statistics. Contrary to an earlier claim, we found no clear evidence for a variation of period derivatives among different superoutbursts of the same object. We present an interpretation that the lengthening of the superhump period is a result of the outward propagation of an eccentricity wave, which is limited by the radius near the tidal truncation. We interpret that late-stage superhumps are rejuvenated excitation of a 3:1 resonance when superhumps in the outer disk are effectively quenched. The general behavior of the period variation, particularly in systems with short orbital periods, appears to follow a scenario proposed in Kato, Maehara, and Monard (2008, PASJ, 60, L23). We also present an observational summary of WZ Sge-type dwarf novae. Many of them have shown long-enduring superhumps during a post-superoutburst stage having longer periods than those during the main superoutburst. The period derivatives in WZ Sge-type dwarf novae are found to be strongly correlated with the fractional superhump excess, or consequently with the mass ratio. WZ Sge-type dwarf novae with a long-lasting rebrightening or with multiple rebrightenings tend to have smaller period derivatives, and are excellent candidates for those systems around or after the period minimum of evolution of cataclysmic variables.

  1. V344 Lyrae: A Touchtone SU UMa Cataclysmic Variable in the Kepler Field

    NASA Technical Reports Server (NTRS)

    Smale, Alan P.; Wood, Matt A.; Still, Martin D.; Howell, Steve B.; Cannizzo, John K.

    2012-01-01

    We report on the analysis of the Kepler short-cadence (SC) light curve of V344 Lyr obtained during 2009 June 20 through 2010 Mar 19 (Q2-Q4). The system is an SU UMa star showing dwarf nova outbursts and superoutbursts, and promises to be a touchstone for CV studies for the foreseeable future. The system displays both positive and negative super humps with periods of 2.20 and 2.06-hr, respectively, and we identify an orbital period of 2.11-hr. The positive super humps have a maximum amplitude of approximately 0.025-mag, the negative super humps a maximum amplitude of approximately 0.8 mag, and the orbital period at quiescence has an amplitude of approximately 0.025 mag. The quality of the Kepler data is such that we can test vigorously the models for accretion disk dynamics that have been emerging in the past several years. The SC data for V344 Lyr are consistent with the model that two physical sources yield positive superhumps: early in the superoutburst. the superhump signal is generated by viscous dissipation within the periodically flexing disk. but late in the superoutburst, the signal is generated as the accretion stream bright spot sweeps around the rim of the non-axisymmetric disk. The disk super humps are roughly anti-phased with the stream/late superhumps. The V344 Lyr data also reveal negative super humps arising from accretion onto a tilted disk precessing in the retrograde direction, and suggest that negative superhumps may appear during the decline of DN outbursts. The period of negative superhumps has a positive P(raised dot) in between outbursts.

  2. BVRI Photometric Study of the Twin, Detached, Near-Contact W UMA Binary, GQ Cancri

    NASA Astrophysics Data System (ADS)

    Caton, Daniel B.; Samec, Ronald G.; Olsen, Amber; Van Hamme, Walter V.; Faulkner, Danny R.

    2017-01-01

    CCD BVRcIc light curves of GQ Cancri were observed in April, 2013 on the SARA North 0.9-m Telescope at Kitt Peak National Observatory in Arizona in remote mode. It is a high amplitude (V~0.9-mag) K0-type eclipsing binary (T1~5250 K) with a photometrically determined mass ratio of M2/M1= 0.99. Its spectral type classifies it as a pre-contact W UMa Binary (PCWB). Binary Maker fits and the Wilson-Devinney Mode 2 solutions show that the binary has a detached binary configuration with fill-outs of 94 and 98% for the primary and secondary component, respectively. As expected, the light curve is asymmetric due to spot activity.Three times of minimum light were calculated, for 2 primary and 1 secondary eclipses from our present observations:HJD I = 2456390.66196±0.00002, 2456406.7056±0.0001HJD II = 2456405.6505±0.0002In total, some 20 times of minimum light covering 17 years of observation were used to determine the following linear ephemeris:JDHelMinI=2456406.70556±0. 00088d + 0. 42220887± 0.00000009 × EAn ephemeris with a weak negative quadratic term with a one probable error significance.It is noted that the solution remained in a detached state for every iteration of the computer runs. The components are truly twins with a computed temperature difference of only 25 K, with the flux of the primary component accounting for 52% of the systems light in B,V,Rc and Ic. A 15 degree equatorial hot spot was iterated on the primary component.

  3. Land use impacts on river health of Uma Oya, Sri Lanka: implications of spatial scales.

    PubMed

    Jayawardana, J M C K; Gunawardana, W D T M; Udayakumara, E P N; Westbrooke, M

    2017-04-01

    Human actions on landscapes are a principal threat to the ecological integrity of river ecosystems worldwide. Tropical landscapes have been poorly investigated in terms of the impact of catchment land cover alteration on water quality and biotic indices in comparison to temperate landscapes. Effects of land cover in the catchment at two spatial scales (catchment and site) on stream physical habitat quality, water quality, macroinvertebrate indices and community composition were evaluated for Uma Oya catchment in the upper Mahaweli watershed, Sri Lanka. The relationship between spatial arrangement of land cover in the catchment and water quality, macroinvertebrate indices and community composition was examined using univariate and multivariate approaches. Results indicate that chemical water quality variables such as conductivity and total dissolved solids are mostly governed by the land cover at broader spatial scales such as catchment scale. Shannon diversity index was also affected by catchment scale forest cover. In stream habitat features, nutrients such as N-NO3(-), macroinvertebrate family richness, %shredders and macroinvertebrate community assemblages were predominantly influenced by the extent of land cover at 200 m site scale suggesting that local riparian forest cover is important in structuring macroinvertebrate communities. Thus, this study emphasizes the importance of services provided by forest cover at catchment and site scale in enhancing resilience of stream ecosystems to natural forces and human actions. Findings suggest that land cover disturbance effects on stream ecosystem health could be predicted when appropriate spatial arrangement of land cover is considered and has widespread application in the management of tropical river catchments.

  4. First Photometric Investigation of the Newly Discovered W UMa-type Binary Star MR Com

    NASA Astrophysics Data System (ADS)

    Qian, S.-B.; Liu, N.-P.; Liao, W.-P.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Wang, J.-J.; Zhao, E.-G.

    2013-08-01

    By analyzing multi-color light curves of the newly discovered W UMa-type binary, MR Com, we discovered that it is a shallow-contact binary with a degree of contact factor of f = 10.0% ± 2.1%. Photometric solutions reveal that MR Com is a W-type system with a mass ratio of q = 3.9 where the less massive component is about 90 K hotter than the more massive one. By investigating all of the available times of minimum light, we found that the general trend of the Observed-Calculated (O - C) curve shows a downward parabolic variation while it undergoes a cyclic variation with a small amplitude of 0.0031 days and a period of 10.1 yr. The downward parabolic change corresponds to a long-term decrease in the orbital period at a rate of \\dot{P}=-5.3\\times {10^{-7}} days yr-1 that may be caused by a combination of a mass transfer and an angular momentum loss (AML) via magnetic braking. Among the 16 shallow-contact systems with a decreasing orbital period, MR Com has the lowest mass ratio (e.g., 1/q = 0.26). The shallow-contact configuration, the low-mass ratio, and the long-term period decrease all suggest that systems similar to MR Com are on the AML-controlled stage of the evolutionary scheme proposed by Qian. They will oscillate around a critical mass ratio and evolve into a deep contact with a higher mass ratio. The small-amplitude cyclic change in the O - C curve was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

  5. FIRST PHOTOMETRIC INVESTIGATION OF THE NEWLY DISCOVERED W UMa-TYPE BINARY STAR MR Com

    SciTech Connect

    Qian, S.-B.; Liu, N.-P.; Liao, W.-P.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Wang, J.-J.; Zhao, E.-G.

    2013-08-01

    By analyzing multi-color light curves of the newly discovered W UMa-type binary, MR Com, we discovered that it is a shallow-contact binary with a degree of contact factor of f = 10.0% {+-} 2.1%. Photometric solutions reveal that MR Com is a W-type system with a mass ratio of q = 3.9 where the less massive component is about 90 K hotter than the more massive one. By investigating all of the available times of minimum light, we found that the general trend of the Observed-Calculated (O - C) curve shows a downward parabolic variation while it undergoes a cyclic variation with a small amplitude of 0.0031 days and a period of 10.1 yr. The downward parabolic change corresponds to a long-term decrease in the orbital period at a rate of P-dot = -5.3 x 10{sup -7} days yr{sup -1} that may be caused by a combination of a mass transfer and an angular momentum loss (AML) via magnetic braking. Among the 16 shallow-contact systems with a decreasing orbital period, MR Com has the lowest mass ratio (e.g., 1/q = 0.26). The shallow-contact configuration, the low-mass ratio, and the long-term period decrease all suggest that systems similar to MR Com are on the AML-controlled stage of the evolutionary scheme proposed by Qian. They will oscillate around a critical mass ratio and evolve into a deep contact with a higher mass ratio. The small-amplitude cyclic change in the O - C curve was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.

  6. Modeling the Radial Velocity Curve of the Water Vapor Maser in VX UMa

    NASA Astrophysics Data System (ADS)

    Salter, D. M.; Benson, P. J.; Strelnitski, V. S.

    1999-12-01

    VX UMa is a unique Mira-type star that demonstrates a triple-peaked spectrum of its 1.35-cm H2O maser emission. We used the high-precision curves of radial velocities of the spectral peaks, obtained by Benson & Little-Marenin from 1988 to 1992, as probes of the kinematics of the masing region. The pronounced periodicity of the radial velocity of the central component, with a period equal to the pulsational period of the optical variations, suggests the involvement of pulsations in the observed excursions of radial velocity. However, the radial velocity of the central spectral component produced by a symmetrical, pulsating spherical layer should be constantly zero. Rotation seems to be the most obvious mechanism to impart a small non-zero component to the central feature. We assume that the bulk of maser radiation originates in the equatorial "belt" around the star and approximate this region as a two-dimensional, rotating and pulsating ring. We found that any combination of rotation and pulsation produces a quadruple peaked, not a triple peaked spectrum. Therefore, some asymmetry in the disk or unequal absorption of the two central peaks by ionized gas (e.g. in the shock responsible for the maser emission) is needed. We demonstrate that one of the central peaks can then undergo periodic changes of its radial velocity with the period of pulsation, as observed. A VLBA experiment that may verify our model is under way. This project was supported by the NSF/REU grant AST-9820555.

  7. An extensive analysis of the triple W UMa type binary FI BOO

    SciTech Connect

    Christopoulou, P.-E.; Papageorgiou, A.

    2013-12-01

    We present a detailed analysis of the interesting W UMa binary FI Boo in view of the spectroscopic signature of a third body through photometry, period variation, and a thorough investigation of solution uniqueness. We obtained new BVR{sub c}I{sub c} photometric data that, when combined with spectroscopic data, enable us to analyze the system FI Boo and determine its basic orbital and physical properties through PHOEBE, as well as the period variation by studying the times of the minima. This combined approach allows us to study the long-term period changes in the system for the first time in order to investigate the presence of a third body and to check extensively the solution uniqueness and the uncertainties of derived parameters. Our modeling indicates that FI Boo is a W-type moderate (f = 50.15% ± 8.10%) overcontact binary with component masses of M {sub h} = 0.40 ± 0.05 M {sub ☉} and M {sub c} = 1.07 ± 0.05 M {sub ☉}, temperatures of T {sub h} = 5746 ± 33 K and T {sub c} = 5420 ± 56 K, and a third body, which may play an important role in the formation and evolution. The results were tested by heuristic scanning and parameter kicking to provide the consistent and reliable set of parameters that was used to obtain the initial masses of the progenitors (1.71 ± 0.10 M {sub ☉} and 0.63 ± 0.01 M {sub ☉}, respectively). We also investigated the evolutionary status of massive components with several sets of widely used isochrones.

  8. OT J002656.6+284933 (CSS101212:002657+284933): an SU UMa-type dwarf nova with the longest superhump period

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Tordai, Tamás; Littlefield, Colin; Kasai, Kiyoshi; Shugarov, Sergey Yu.; Katysheva, Natalia; Zaostrojnykh, Anna M.; Pickard, Roger D.; de Miguel, Enrique; Antonyuk, Kirill; Antonyuk, Oksana; Pavlenko, Elena P.; Pit, Nikolai; Itoh, Hiroshi; Ruiz, Javier; Isogai, Keisuke; Kimura, Mariko; Wakamatsu, Yasuyuki; Vanmunster, Tonny; Stone, Geoff

    2017-06-01

    We observed the 2016 outburst of OT J002656.6+284933 (CSS101212:002657+284933) and found that it has the longest recorded [0.13225(1) d on average] superhumps among SU UMa-type dwarf novae. The object is the third known SU UMa-type dwarf nova above the period gap. The outburst, however, was unlike ordinary long-period SU UMa-type dwarf novae in that it showed two post-outburst rebrightenings. It showed superhump evolution similar to short-period SU UMa-type dwarf novae. We could constrain the mass ratio to less than 0.15 (most likely between 0.10 and 0.15) by using superhump periods in the early and post-superoutburst stages. These results suggest the possibility that OT J002656.6+284933 has an anomalously undermassive secondary and it should have followed a different evolutionary track from the standard one.

  9. Uma grade de perfis teóricos para estrelas massivas em transição

    NASA Astrophysics Data System (ADS)

    Nascimento, C. M. P.; Machado, M. A.

    2003-08-01

    Na XXVIII Reunião Anual da Sociedade Astronômica Brasileira (2002) apresentamos uma grade de perfis calculados de acordo com os pontos da trajetória evolutiva de metalicidade solar, Z = 0.02 e taxa de perda de massa () padrão, para estrelas com massa inicial de 25, 40, 60, 85 e 120 massas solares. Estes perfis foram calculados com o auxílio de um código numérico adequado para descrever os ventos de objetos massivos, supondo simetria esférica, estacionaridade e homogeneidade. No presente trabalho, apresentamos a complementação da grade com os perfis teóricos relativos às trajetórias de Z = 0.02 com taxa de perda de massa dobrada em relação a padrão (2´), e de metalicidade Z = 0.008. Para cada ponto das três trajetórias obtemos os perfis teóricos de Ha, Hb, Hg e Hd, e como esperado eles se apresentam em pura emissão, pura absorção ou em P-Cygni. Para valores de taxa de perda de massa muito baixos (~10-7) não há formação de linhas, o que é visto nos primeiros pontos em todas as trajetórias. Em geral, para um mesmo ponto a componente de emissão diminui e a absorção aumenta de Ha para Hd. É verificado que as trajetórias com Z = 0.02 e padrão possuem menos circuitos (loops) do que as com metalicidade Z = 0.02 e 2´ padrão, e seus perfis são, em geral, menos intensos. Em relação a trajetória de Z = 0.008, verifica-se menos circuitos e maior variação em luminosidade, e seus perfis mostram-se em, algumas trajetórias, mais intensos. Verificamos também que, pontos distintos em uma mesma trajetória, apresentam perfis diferentes para valores similares de luminosidade e temperatura efetiva. Sendo assim, uma grade de perfis teóricos parece ser útil para fornecer uma informação preliminar sobre o estágio evolutivo de uma estrela massiva.

  10. Apparent Motion of the Sun, Shadows of Objects and Measurement of Time in the View of Seventh Grade Students of Middle School. (Breton Title: Movimento Aparente do Sol, Sombras dos Objetos e Medição do Tempo na Visão de Alunos do Sétimo Ano do Ensino Fundamental.) Movimiento Aparente del Sol, Sombras de los Objetos y Medición del Tiempo en la Visión de Estudiantes del Séptimo Grado del Ciclo Pirmario

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel

    2013-07-01

    The apparent motion of the Sun on the celestial sphere and the behavior of the shadows of objects over time are observable phenomena in everyday life. However, students often do not have a proper understanding of such occurrences, and can even display misconceptions about them. Therefore, we performed a research in order to know students' notions about these subjects and to evaluate the contribution to their understanding brought about by an activity performed with an interactive sundial in an informal learning environment. We investigated the ideas of 43 students from the seventh grade of middle school by applying a test with open questions before and after an activity with an analemmatic sundial, conducted by a monitor. A significant proportion of students were initially unaware of most of the phenomena treated. The intervention performed helped the students to assimilate new concepts, providing the contact with new phenomena and to a lesser degree, the development of explanations about them, indicating an educational potential of this action. However, the contribution to the understanding of some of the ideas explored was small, pointing to the need to make additional observations, studies and discussions. O movimento aparente do Sol na esfera celeste e o comportamento das sombras dos objetos com o passar do tempo são fenômenos observáveis no dia a dia. No entanto, muitas vezes os estudantes não possuem uma compreensão adequada de tais ocorrências, podendo inclusive exibir concepções alternativas a seu respeito. Por isso, efetuou-se uma pesquisa com o intuito de conhecer as noções dos alunos sobre esses temas e avaliar a contribuição para seu entendimento propiciada por uma atividade feita com um relógio de Sol interativo, em um ambiente de ensino informal. Foram investigadas as ideias de 43 alunos do sétimo ano do Ensino Fundamental mediante a aplicação de um teste com questões abertas antes e depois de uma atividade com um relógio de Sol

  11. The mechanism of the reduction of [AnO2]2+ (An = U, Np, Pu) in aqueous solution, and by Fe(II) containing proteins and mineral surfaces, probed by DFT calculations.

    PubMed

    Sundararajan, Mahesh; Assary, Rajeev S; Hillier, Ian H; Vaughan, David J

    2011-11-14

    The fate of actinyl species in the environment is closely linked to oxidation state, since the reduction of An(VI) to An(IV) greatly decreases their mobility due to the precipitation of the relatively insoluble An(IV) species. Here we study the mechanism of the reduction of [AnO(2)](2+) (An = U, Np, Pu) both in aqueous solution and by Fe(II) containing proteins and mineral surfaces, using density functional theory calculations. We find a disproportionation mechanism involving a An(V)-An(V) cation-cation complex, and we have investigated how these complexes are formed in the different environments. We find that the behaviour of U and Pu complexes are similar, but the reduction of Np(V) to Np(IV) would seems to be more difficult, in line with the experimental finding that Np(V) is generally more stable than U(V) or Pu(V). Although the models we have used are somewhat idealised, our calculations suggest that there are strong similarities between the biotic and abiotic reduction pathways.

  12. WZ Cephei: A Dynamically Active W UMa-Type Binary Star

    NASA Astrophysics Data System (ADS)

    Jeong, Jang-Hae; Kim, Chun-Hwey

    2011-09-01

    An intensive analysis of 185 timings of WZ Cep, including our new three timings, was made to understand the dynamical picture of this active W UMa-type binary. It was found that the orbital period of the system has complexly varied in two cyclical components superposed on a secularly downward parabola over about 80y. The downward parabola, corresponding to a secular period decrease of -9.d97 × 10-8 y-1, is most probably produced by the action of both angular momentum loss (AML) due to magnetic braking and mass-transfer from the massive primary component to the secondary. The period decrease rate of -6.d72 × 10-8 y-1 due to AML contributes about 67% to the observed period decrease. The mass flow of about 5.16 × 10-8 M⊙ y-1 from the primary to the secondary results the remaining 33% period decrease. Two cyclical components have an 11.y8 period with amplitude of 0.d0054 and a 41.y3 period with amplitude of 0.d0178. It is very interesting that there seems to be exactly in a commensurable 7:2 relation between their mean motions. As the possible causes, two rival interpretations (i.e., light-time effects (LTE) by additional bodies and the Applegate model) were considered. In the LTE interpretation, the minimum masses of 0.30 M⊙ for the shorter period and 0.49 M⊙ for the longer one were calculated. Their contributions to the total light were at most within 2%, if they were assumed to be main-sequence stars. If the LTE explanation is true for the WZ Cep system, the 7:2 relation found between their mean motions would be interpreted as a stable 7:2 orbit resonance produced by a long-term gravitational interaction between two tertiary bodies. In the Applegate model interpretation, the deduced model parameters indicate that the mechanism could work only in the primary star for both of the two period modulations, but could not in the secondary. However, we couldn't find any meaningful relation between the light variation and the period variability from the historical

  13. [Anatomy of the ano-rectal region].

    PubMed

    Van Limborgh, J; Los, J A; De Blok, S; De Jong, E

    1980-01-01

    Following a survey of the anatomical characteristics of the rectum and the posterior part of the pelvic floor, a description is given of the fibrous sheath enveloping the rectum, and of the fibrous leaves and septa which traverse the adipose tissue of the subperitoneal space and the ischiorectal fossa. These fibrous structures contain the blood vessels, the lymphatics and the nerves, the distribution of which is described in detail. The fibrous structures, in which many smooth muscle fibres are present, not only enclose the vessels and nerves but also form the suspensory apparatus of the rectum.

  14. Estudios Sociales Para ninos de cinco anos.

    ERIC Educational Resources Information Center

    Van Camp, Sara S.

    1982-01-01

    Suggests that kindergarten teachers should once a week bring to class a news photograph which they can discuss with the children. Such an exercise can be used to create among the children a wider awareness of the world and to counter their tendency to focus exclusively on the self. (Author/RH)

  15. Survey of period variations of superhumps in SU UMa-type dwarf novae. IX. The ninth year (2016-2017)

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Isogai, Keisuke; Hambsch, Franz-Josef; Vanmunster, Tonny; Itoh, Hiroshi; Monard, Berto; Tordai, Tamás; Kimura, Mariko; Wakamatsu, Yasuyuki; Kiyota, Seiichiro; Miller, Ian; Starr, Peter; Kasai, Kiyoshi; Shugarov, Sergey Yu.; Chochol, Drahomir; Katysheva, Natalia; Zaostrojnykh, Anna M.; Sekeráš, Matej; Kuznyetsova, Yuliana G.; Kalinicheva, Eugenia S.; Golysheva, Polina; Krushevska, Viktoriia; Maeda, Yutaka; Dubovsky, Pavol A.; Kudzej, Igor; Pavlenko, Elena P.; Antonyuk, Kirill A.; Pit, Nikolaj V.; Sosnovskij, Aleksei A.; Antonyuk, Oksana I.; Baklanov, Aleksei V.; Pickard, Roger D.; Kojiguchi, Naoto; Sugiura, Yuki; Tei, Shihei; Yamamura, Kenta; Matsumoto, Katsura; Ruiz, Javier; Stone, Geoff; Cook, Lewis M.; de Miguel, Enrique; Akazawa, Hidehiko; Goff, William N.; Morelle, Etienne; Kafka, Stella; Littlefield, Colin; Bolt, Greg; Dubois, Franky; Brincat, Stephen M.; Maehara, Hiroyuki; Sakanoi, Takeshi; Kagitani, Masato; Imada, Akira; Voloshina, Irina B.; Andreev, Maksim V.; Sabo, Richard; Richmond, Michael; Rodda, Tony; Nelson, Peter; Nazarov, Sergey; Mishevskiy, Nikolay; Myers, Gordon; Denisenko, Denis; Stanek, Krzysztof Z.; Shields, Joseph V.; Kochanek, Christopher S.; Holoien, Thomas W.-S.; Shappee, Benjamin; Prieto, José L.; Itagaki, Koh-ichi; Nishiyama, Koichi; Kabashima, Fujio; Stubbings, Rod; Schmeer, Patrick; Muyllaert, Eddy; Horie, Tsuneo; Shears, Jeremy; Poyner, Gary; Moriyama, Masayuki

    2017-10-01

    Continuing the project described by Kato et al. (2009, PASJ, 61, S395), we collected times of superhump maxima for 127 SU UMa-type dwarf novae observed mainly during the 2016-2017 season and characterized these objects. We provide updated statistics of the relation between the orbital period and the variation of superhumps, the relation between period variations and the rebrightening type in WZ Sge-type objects. We obtained the period minimum of 0.05290(2) d and confirmed the presence of the period gap above the orbital period ˜0.09 d. We note that four objects (NY Her, 1RXS J161659.5+620014, CRTS J033349.8-282244, and SDSS J153015.04+094946.3) have supercycles shorter than 100 d but show infrequent normal outbursts. We consider that these objects are similar to V503 Cyg, whose normal outbursts are likely suppressed by a disk tilt. These four objects are excellent candidates to search for negative superhumps. DDE 48 appears to be a member of ER UMa-type dwarf novae. We identified a new eclipsing SU UMa-type object, MASTER OT J220559.40-341434.9. We observed 21 WZ Sge-type dwarf novae during this interval and report 18 of them in this paper. Among them, ASASSN-16js is a good candidate for a period bouncer. ASASSN-16ia showed a precursor outburst for the first time in a WZ Sge-type superoutburst. ASASSN-16kg, CRTS J000130.5+050624, and SDSS J113551.09+532246.2 are located in the period gap. We have newly obtained 15 orbital periods, including periods from early superhumps.

  16. Survey of period variations of superhumps in SU UMa-type dwarf novae. VII. The seventh year (2014-2015)

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Hambsch, Franz-Josef; Dubovsky, Pavol A.; Kudzej, Igor; Monard, Berto; Miller, Ian; Itoh, Hiroshi; Kiyota, Seiichiro; Masumoto, Kazunari; Fukushima, Daiki; Kinoshita, Hiroki; Maeda, Kazuki; Mikami, Jyunya; Matsuda, Risa; Kojiguchi, Naoto; Kawabata, Miho; Takenaka, Megumi; Matsumoto, Katsura; de Miguel, Enrique; Maeda, Yutaka; Ohshima, Tomohito; Isogai, Keisuke; Pickard, Roger D.; Henden, Arne; Kafka, Stella; Akazawa, Hidehiko; Otani, Noritoshi; Ishibashi, Sakiko; Ogi, Minako; Tanabe, Kenji; Imamura, Kazuyoshi; Stein, William; Kasai, Kiyoshi; Vanmunster, Tonny; Starr, Peter; Oksanen, Arto; Pavlenko, Elena P.; Antonyuk, Oksana I.; Antonyuk, Kirill A.; Sosnovskij, Aleksei A.; Pit, Nikolaj V.; Babina, Julia V.; Sklyanov, Aleksandr; Novák, Rudolf; Dvorak, Shawn; Michel, Raúl; Masi, Gianluca; Littlefield, Colin; Ulowetz, Joseph; Shugarov, Sergey Yu.; Golysheva, Polina Yu.; Chochol, Drahomir; Krushevska, Viktoriia; Ruiz, Javier; Tordai, Tamás; Morelle, Etienne; Sabo, Richard; Maehara, Hiroyuki; Richmond, Michael; Katysheva, Natalia; Hirosawa, Kenji; Goff, William N.; Dubois, Franky; Logie, Ludwig; Rau, Steve; Voloshina, Irina B.; Andreev, Maksim V.; Shiokawa, Kazuhiko; Neustroev, Vitaly V.; Sjoberg, George; Zharikov, Sergey; James, Nick; Bolt, Greg; Crawford, Tim; Buczynski, Denis; Cook, Lewis M.; Kochanek, Christopher S.; Shappee, Benjamin; Stanek, Krzysztof Z.; Prieto, José L.; Denisenko, Denis; Nishimura, Hideo; Mukai, Masaru; Kaneko, Shizuo; Ueda, Seiji; Stubbings, Rod; Moriyama, Masayuki; Schmeer, Patrick; Muyllaert, Eddy; Shears, Jeremy; Modic, Robert J.; Paxson, Kevin B.

    2015-12-01

    Continuing the project described by Kato et al. (2009, PASJ, 61, S395), we collected times of superhump maxima for 102 SU UMa-type dwarf novae, observed mainly during the 2014-2015 season, and characterized these objects. Our project has greatly improved the statistics of the distribution of orbital periods, which is a good approximation of the distribution of cataclysmic variables at the terminal evolutionary stage, and has confirmed the presence of a period minimum at a period of 0.053 d and a period spike just above this period. The number density monotonically decreased toward the longer period and there was no strong indication of a period gap. We detected possible negative superhumps in Z Cha. It is possible that normal outbursts are also suppressed by the presence of a disk tilt in this system. There was no indication of enhanced orbital humps just preceding the superoutburst, and this result favors the thermal-tidal disk instability as the origin of superoutbursts. We detected superhumps in three AM CVn-type dwarf novae. Our observations and recent other detections suggest that 8% of objects showing dwarf nova-type outbursts are AM CVn-type objects. AM CVn-type objects and EI Psc-type objects may be more abundant than previously recognized. OT J213806, a WZ Sge-type object, exhibited remarkably different features between the 2010 and 2014 superoutbursts. Although the 2014 superoutburst was much fainter, the plateau phase was shorter than the 2010 one, and the course of the rebrightening phase was similar. This object indicates that the O - C diagrams of superhumps can indeed be variable, at least in WZ Sge-type objects. Four deeply eclipsing SU UMa-type dwarf novae (ASASSN-13cx, ASASSN-14ag, ASASSN-15bu, and NSV 4618) were identified. We studied long-term trends in supercycles in MM Hya and CY UMa and found systematic variations of supercycles of ˜20%.

  17. Time sequence spectroscopy of AW UMa. The 518 nm Mg I triplet region analyzed with broadening functions

    SciTech Connect

    Rucinski, Slavek M.

    2015-02-01

    High-resolution spectroscopic observations of AW UMa, obtained on three consecutive nights with a median time resolution of 2.1 minutes, have been analyzed using the broadening function method in the spectral window of 22.75 nm around the 518 nm Mg i triplet region. Doppler images of the system reveal the presence of vigorous mass motions within the binary system; their presence puts into question the solid-body rotation assumption of the contact binary model. AW UMa appears to be a very tight, semi-detached binary; the mass transfer takes place from the more massive to the less massive component. The primary, a fast-rotating star with Vsini=181.4±2.5 km s{sup −1}, is covered with inhomogeneities: very slowly drifting spots and a dense network of ripples more closely participating in its rotation. The spectral lines of the primary show an additional broadening component (called the “pedestal”) that originates either in the equatorial regions, which rotate faster than the rest of the star by about 50 km s{sup −1}, or in an external disk-like structure. The secondary component appears to be smaller than predicted by the contact model. The radial velocity field around the secondary is dominated by accretion of matter transferred from (and possibly partly returned to) the primary component. The parameters of the binary are Asini=2.73±0.11 R{sub ⊙} and M{sub 1}sin{sup 3}i=1.29±0.15 M{sub ⊙}, M{sub 2}sin{sup 3}i=0.128±0.016 M{sub ⊙}. The mass ratio, q{sub sp}=M{sub 2}/M{sub 1}=0.099±0.003, while still the most uncertain among the spectroscopic elements, is substantially different from the previous numerous and mutually consistent photometric investigations which were based on the contact model. It should be studied why photometry and spectroscopy give such discrepant results and whether AW UMa is an unusual object or if only very high-quality spectroscopy can reveal the true nature of W UMa-type binaries.

  18. Mass Flux of Tephra Sampled Frequently During the Ongoing Halema`uma`u Eruption (Invited)

    NASA Astrophysics Data System (ADS)

    Swanson, D.; Wooten, K.; Orr, T. R.

    2009-12-01

    The ongoing summit eruption of Kilauea provides an unparalleled opportunity to track, almost daily, the production of tephra. The eruption began on 19 March 2008, and tephra has been erupted every day since then to the end of August 2009. Most of the time, tephra is ejected quasi-continuously from the vent accompanied by a light gray to white gas plume, occasionally broken by a more vigorous pulse (“brown plume”) richer in ejecta. In early April 2008, an array of 10 plastic buckets was placed within 400 m of the new vent in Halema`uma`u down the prevailing NE wind direction. The configuration of the array, spanning an area of about 73,000 m2, has not changed since then. Buckets are emptied frequently, initially every day and, since summer 2008, on all weekdays. The contents are dried and weighed, and an “average network accumulation rate” is calculated in g/m2/hour. In addition, componentry analyses are made of the >0.5-mm size fraction from a bucket near the vent, in order to categorize the tephra into juvenile and lithic fractions. To estimate the total mass of tephra ejected from the vent for a given collection, we first drew isomass contours for several daily collections and plotted isomass versus square root of area to obtain the total mass of the deposit. From this, we developed an empirical multiplication factor that allows us to estimate, within ~25 percent, the total ejected mass per day in kilograms from the total collected mass in grams. The tephra is a mix of vitric and lithic pyroclasts, mostly ash in size. The vitric clasts, interpreted as juvenile, include Pele’s hair and tears, hollow spherules, dumbbells, pumice, and bits of coarsely vesicular glass. All these clasts were probably produced by weak spattering at the top of the lava column, which has rarely been seen. Especially since fall 2008, some vitric clasts are partly coated with secondary minerals or rock dust. We interpret such clasts as recycled, first erupted during spattering

  19. The 2008-2009 Eruption in Halema`uma`u Crater, Kilauea Volcano

    NASA Astrophysics Data System (ADS)

    Kauahikaua, J. P.; Orr, T. R.; Patrick, M. R.; Swanson, D.; Poland, M. P.; Miklius, A.; Wilson, D.; Sutton, A. J.; Elias, T.; Thornber, C. R.; Wooten, K.

    2009-12-01

    Early in the 26th year of Kilauea volcano’s ongoing east rift zone eruption, a distinct increase in activity was detected at Kilauea summit. By February 2008, the southern part of the summit caldera was bathed in high concentrations of SO2 prompting Hawai`i Volcanoes National Park to close public access. A vigorous fuming area at the base of the east wall of Halema`uma`u Crater was noted on March 12, and the first throat-clearing explosion occurred from that location a week later. This, the first explosive eruption of Kilauea's summit since 1924, was followed by 7 more before the first major vent collapse in early December 2008 buried the lava column beneath rubble, extinguished vent glow, and reduced gas emissions. The vent slowly came back to life in early 2009, exhibiting behavior similar to that in 2008, until another major collapse in mid-2009 reburied the vent and again extinguished glow and reduced gas emissions. As of August 2009, glow had returned and gas emissions had increased, a total of 2,200 tonnes of lithic and juvenile tephra had been erupted, and the dimensions of the vent opening in the crater floor increased to 125 x 133 m. Chemical uniformity of magma erupted from the summit and rift zone vents unambiguously demonstrate their direct connection. The low explosive intensity and location of the 2008-9 explosive activity within the heavily monitored and easily accessible summit have allowed a number of near-vent studies. Near-daily ashfall measurements have revealed temporal variations in tephra production and changes in the proportion of juveniles and lithics. Direct views of the lava surface within the vent allowed cross-correlation with seismic and geodetic signals to suggest new interpretations of tremor, infrasound, and tilt data. Near-source emission measurements allowed uniquely full characterization of gas content and associated hazards. Additional hazards posed by the summit activity include near-vent ballistic impacts and low air quality

  20. A New Look at the Eclipse Timing Variation Diagram Analysis of Selected 3-body W UMa Systems

    NASA Astrophysics Data System (ADS)

    Christopoulou, P.-E.; Papageorgiou, A.

    2015-07-01

    The light travel effect produced by the presence of tertiary components can reveal much about the origin and evolution of over-contact binaries. Monitoring of W UMa systems over the last decade and/or the use of publicly available photometric surveys (NSVS, ASAS, etc.) has uncovered or suggested the presence of many unseen companions, which calls for an in-depth investigation of the parameters derived from cyclic period variations in order to confirm or reject the assumption of hidden companion(s). Progress in the analysis of eclipse timing variations is summarized here both from the empirical and the theoretical points of view, and a more extensive investigation of the proposed orbital parameters of third bodies is proposed. The code we have developed for this, implemented in Python, is set up to handle heuristic scanning with parameter perturbation in parameter space, and to establish realistic uncertainties from the least squares fitting. A computational example is given for TZ Boo, a W UMa system with a spectroscopically detected third component. Future options to be implemented include MCMC and bootstrapping.

  1. Comparing the precision 2009 and 2012 light curves of the precontact W UMa binary V1001 Cassiopeia

    SciTech Connect

    Samec, R. G.; Koenke, S. S.; Faulkner, D. R.

    2015-01-01

    A 2012 follow up to the analysis of 2009 observations is presented for the very short period (∼0.43 days) precontact W UMa binary (PCWB) V1001 Cassiopeia. Its short period, similar to the majority of W UMa binaries, and its distinct EA light curve make it a very rare and interesting system for continuing photometric investigation. Previous photometric VRI standard magnitudes give a K4 spectral type. Our solutions of light curves separated by some three years give approximately the same physical parameters. However, the spots have radically changed in temperature, area, and position. While only one dark spot was used to model the first curves, two hot spots are now needed. This affects the overall shape of the light curve, especially in the secondary eclipses in B and V. Additional eclipse timings now show that the orbital period is changing. We conclude that spots are very active on this solar-type dwarf system and that it may mimic its larger cousins, the RS CVn binaries. The conclusion is that analysis now needs to be directed at the continuous time evolution of PCWBs.

  2. Light curve solutions of six eclipsing binaries at the lower limit of periods for W UMa stars

    NASA Astrophysics Data System (ADS)

    Kjurkchieva, Diana P.; Dimitrov, Dinko P.; Ibryamov, Sunay I.

    2015-09-01

    Photometric observations are presented in V and I bands of six eclipsing binaries at the lower limit of the orbital periods for W UMa stars. Three of them are newly discovered eclipsing systems. The light curve solutions reveal that all short-period targets are contact or overcontact binaries and six new binaries are added to the family of short-period systems with estimated parameters. Four binaries have components that are equal in size and a mass ratio near 1. The phase variability shown by the V-I colors of all targets may be explained by lower temperatures on their back surfaces than those on their side surfaces. Five systems exhibit the O'Connell effect that can be modeled by cool spots on the side surfaces of their primary components. The light curves of V1067 Her in 2011 and 2012 are fitted by diametrically opposite spots. Applying the criteria for subdivision of W UMa stars to our targets leads to ambiguous results.

  3. Observations and light curve solutions of the eclipsing W UMa binaries CSS J071813.2+505000, NSVS 2459652, NSVS 7178717 and NSVS 7377875

    NASA Astrophysics Data System (ADS)

    Kjurkchieva, D. P.; Popov, V. A.; Vasileva, D. L.; Petrov, N. I.

    2017-04-01

    Photometric observations in Sloan g' and i' bands of four eclipsing W UMa binaries are presented. They allowed the improvement of system ephemerides. The light curve solutions led to the following results: (i) CSS J071813.2+505000 is barely an overcontact system, NSVS 2459652 and NSVS 7377875 are overcontact binaries with an intermediate fillout factor, while NSVS 7178717 has a deep-contact configuration; (ii) NSVS 7178717 undergoes total eclipses while the other three targets exhibit partial eclipses; (iii) The components of each target are almost the same in temperature: those of CSS J071813.2+505000 are early G stars while those of the other three targets are of K spectral type; (iv) The targets with late components reveal spot activity; (v) NSVS 2459652 and NSVS 7377875 are W UMa binaries of H subtype; (vi) The relation mass ratio - luminosity ratio of our targets confirms the results from previous statistical analysis of W UMa systems.

  4. Propriedades de estruturas temporais rápidas submilimétricas durante uma grande explosão solar

    NASA Astrophysics Data System (ADS)

    Raulin, J.-P.; Kaufmann, P.; Gimenez de Castro, C. G.; Pacini, A. A.; Makhmutov, V.; Levato, H.; Rovira, M.

    2003-08-01

    Apresentamos novas propriedades de variações rápidas da emissão submilimétrica durante uma das maiores explosões solares do ciclo solar 23. Os dados analisados neste estudo foram obtidos com o Telescópio Solar Submilimétrico (SST), que observa o Sol em 212 GHz e 405 GHz, e comparados com emissões em Raios-X duros e Raios-gama (fótons de energia > 10 MeV), que foram obtidas pelo experimento GRS do Yohkoh. Aplicamos diferentes metodologias para detectar e caracterizar, ao longo do evento, os pulsos submilimétricos (duração de 50-300 ms) detectados acima de uma componente mais lenta (alguns minutos). Os resultados mostram que durante a fase impulsiva, num instante próximo ao tempo do máximo do evento, houve um aumento da ocorrência de maiores e de mais rápidas estruturas temporais. Também identificamos uma boa correlação com as emissões em raios-X e raios-gama (até a faixa de energia 10-100 MeV), indicando que os pulsos rápidos submilimétricos refletiram injeções primárias de energia durante o evento.O espectro do fluxo desses pulsos é crescente com a freqüência entre 212 and 405 GHz, na maioria dos casos, ao contrário do observado para a componente gradual. As posições calculadas para as estruturas rápidas são discretas, compactas e localizadas em toda a área da região ativa, o que é previsto nos modelos de explosões solares decorrentes de instabilidades múltiplas em diferentes pequenas regiões. Por outro lado, a posição calculada para a componente lenta é estável durante a fase impulsiva. Assim, a comparação entre as características do espectro de fluxo e da localização da emissão, para os pulsos rápidos e para a componente gradual, sugere que as respectivas emissões são de natureza diferente.

  5. The first confirmed superoutburst of the SU UMa-type dwarf nova SDSS J083931.35+282824.0

    NASA Astrophysics Data System (ADS)

    Shears, J.; de Miguel, E.; Roberts, G.; Collins, D. F..; Myers, G.; Campbell, T.

    2011-12-01

    We report unfiltered CCD photometry of the first confirmed superoutburst in 2010 April of the recently discovered dwarf nova SDSS J083931.35+282824.0. From a quiescence magnitude of ~19.8 it rose to 14.0, an outburst amplitude of at least 5.8 magnitudes. Only the plateau phase of the outburst was observed, during which superhumps with peak-to-peak amplitude of up to 0.28 magnitudes were present, confirming this to be an SU UMa-type dwarf nova. The mean superhump period was Psh= 0.07836(2) during the first 3 days and this subsequently decreased to 0.07800(3)d. Analysis of the data revealed tentative evidence for an orbital period Porb= 0.07531(25)d. The fractional superhump period excess was e= 0.039(6), which is consistent with other dwarf novae of similar orbital period.

  6. Peculiarities of the SU UMa-Type Dwarf Nova V1504 Cyg Behavior in 1994 - 2012 Years

    NASA Astrophysics Data System (ADS)

    Antonyuk, O. I.; Pavlenko, E. P.

    2013-12-01

    For the SU UMa-type dwarf nova V1504 Cyg on the data base of the CrAO (1998 - 2009), space telescope "Kepler" (2009 - 2011), AAVSO and VSNET (1994 - 2012) we found as follows: 1) the supercycle length varying in average from 100 to 140 d; 2) the normal outbursts show a bimodal cycles lengths distributions with centers 8 - 9 days and 11 days within the range of 5 - 22 days; 3) for the quiescent data JD 2451737-2451745 we have detected the 0.0677-d periodicity that probably connected to the negative superhumps, and for the JD 245497 - 2454974 - these consisting either with simultaneous existing of positive and negative superhumps or with one of these periods.

  7. BVR{sub c}I{sub c} observations and analyses on V2421 Cygni, a precontact W UMa binary

    SciTech Connect

    Samec, R. G.; Shebs, Travis S.; Faulkner, D. R.; Van Hamme, W.; Mathis, R. F.

    2014-01-01

    We present the first precision BVRI light curves, synthetic light curve solutions, and a period study for the high amplitude solar type binary, V2421 Cygni. The light curves have the appearance of an Algol (EA) type; however, it is made up of dwarf solar type components in a detached mode with a period of only 0.6331 days with an amplitude of about a full magnitude, i.e., it is a precontact W UMa binary. Flare-like disruptions occur in the light curves following the primary and secondary eclipses possibly due to the line-of-sight track of a gas stream. An associated stream spot and splash spot cause bright equatorial spots on the stellar surface of the primary star. The more massive star is the gainer, making this system a classic, albeit dwarf, Algol.

  8. CSS090530:144011+494734: a new SU UMa-type dwarf nova in Boötes

    NASA Astrophysics Data System (ADS)

    Boyd, D.; Dunckel, N.; Foote, J.; Miller, I.

    2010-08-01

    We report photometry and analysis of a previously unknown SU UMa-type dwarf nova in Boötes detected in outburst by the Catalina Real-time Transient Survey on 2009 May 30, with the discovery identifier CSS090530:144011+494734. This apparently stellar object had previously been catalogued by the Sloan Digital Sky Survey as SDSS J144011.01+494733.4. We measured its mean superhump period over the first 3 days following detection as 0.06500(4)d, at which point this changed to 0.06438(3)d. We detected a possible orbital period of 0.06322(8)d implying a mean superhump period excess of 0.020(2). After detection, the dwarf nova maintained steady brightness for 5 days before starting to fade. The outburst amplitude was 5.5 magnitudes above its quiescent level.

  9. Survey of period variations of superhumps in SU UMa-type dwarf novae. VIII. The eighth year (2015-2016)

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Hambsch, Franz-Josef; Monard, Berto; Vanmunster, Tonny; Maeda, Yutaka; Miller, Ian; Itoh, Hiroshi; Kiyota, Seiichiro; Isogai, Keisuke; Kimura, Mariko; Imada, Akira; Tordai, Tamás; Akazawa, Hidehiko; Tanabe, Kenji; Otani, Noritoshi; Ogi, Minako; Ando, Kazuko; Takigawa, Naoki; Dubovsky, Pavol A.; Kudzej, Igor; Shugarov, Sergey Yu.; Katysheva, Natalia; Golysheva, Polina; Gladilina, Natalia; Chochol, Drahomir; Starr, Peter; Kasai, Kiyoshi; Pickard, Roger D.; Miguel, Enrique de; Kojiguchi, Naoto; Sugiura, Yuki; Fukushima, Daiki; Yamada, Eiji; Uto, Yusuke; Kamibetsunawa, Taku; Tatsumi, Taiki; Takeda, Nao; Matsumoto, Katsura; Cook, Lewis M.; Pavlenko, Elena P.; Babina, Julia V.; Pit, Nikolaj V.; Antonyuk, Oksana I.; Antonyuk, Kirill A.; Sosnovskij, Aleksei A.; Baklanov, Aleksei V.; Kafka, Stella; Stein, William; Voloshina, Irina B.; Ruiz, Javier; Sabo, Richard; Dvorak, Shawn; Stone, Geoff; Andreev, Maksim V.; Antipin, Sergey V.; Zubareva, Alexandra M.; Zaostrojnykh, Anna M.; Richmond, Michael; Shears, Jeremy; Dubois, Franky; Logie, Ludwig; Rau, Steve; Vanaverbeke, Siegfried; Simon, Andrei; Oksanen, Arto; Goff, William N.; Bolt, Greg; Dębski, Bartłomiej; Kochanek, Christopher S.; Shappee, Benjamin; Stanek, Krzysztof Z.; Prieto, José L.; Stubbings, Rod; Muyllaert, Eddy; Hiraga, Mitsutaka; Horie, Tsuneo; Schmeer, Patrick; Hirosawa, Kenji

    2016-08-01

    Continuing the project described by Kato et al. (2009, PASJ, 61, S395), we collected times of superhump maxima for 128 SU UMa-type dwarf novae observed mainly during the 2015-2016 season and characterized these objects. The data have improved the distribution of orbital periods, the relation between the orbital period and the variation of superhumps, and the relation between period variations and the rebrightening type in WZ Sge-type objects. Coupled with new measurements of mass ratios using growing stages of superhumps, we now have a clearer and statistically greatly improved evolutionary path near the terminal stage of evolution of cataclysmic variables. Three objects (V452 Cas, KK Tel, and ASASSN-15cl) appear to have slowly growing superhumps, which is proposed to reflect the slow growth of the 3 : 1 resonance near the stability border. ASASSN-15sl, ASASSN-15ux, SDSS J074859.55+312512.6, and CRTS J200331.3-284941 are newly identified eclipsing SU UMa-type (or WZ Sge-type) dwarf novae. ASASSN-15cy has a short (˜0.050 d) superhump period and appears to belong to EI Psc-type objects with compact secondaries having an evolved core. ASASSN-15gn, ASASSN-15hn, ASASSN-15kh, and ASASSN-16bu are candidate period bouncers with superhump periods longer than 0.06 d. We have newly obtained superhump periods for 79 objects and 13 orbital periods, including periods from early superhumps. In order that future observations will be more astrophysically beneficial and rewarding to observers, we propose guidelines on how to organize observations of various superoutbursts.

  10. The Understanding of Astronomy Concepts by Students from Basic Education of a Public School. (Spanish Title: El Entendimiento de Conceptos de Aastronmía Por Los Alumnos de Educación Básica en Una Escuela Pública.) O Entendimento de Conceitos de Astronomia Por Alunos da Educação Básica: O Caso de Uma Escola Pública Brasileira

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel; dos Santos, Carlos

    2011-07-01

    movimiento de la Luna, el movimiento aparente del Sol sobre la esfera celeste, los eclipses, las dimensiones y las distancias en el Universo, el brillo de las estrellas y su observación de la Tierra. Si bien ha habido un pequeño progreso en la proporción de respuestas aceptables científicamente cuando se cotejó el octavo grado de la enseñanza primaria con el quinto, y el último año de la enseñanza secundaria con el primero, se observó un predominio de las concepciones alternativas en relación a la mayoría de los temas explorados, que continuó hasta los últimos años de la educación básica. Una comparación con los datos encontrados en investigaciones realizadas en otros contextos socioculturales revelaron, en muchos aspectos, conceptos y dificultades similares expresadas por los estudiantes. Apresentam-se os resultados de uma investigação sobre a compreensão de conceitos astronômicos básicos, da qual participaram 561 estudantes da quinta série do Ensino Fundamental ao terceiro ano do Ensino Médio de uma escola pública da cidade de Foz do Iguaçu. Um teste com 20 questões de múltipla escolha foi aplicado para identificar as concepções mais comuns expressadas pelos alunos. Esse instrumento de coleta de dados foi elaborado com base na literatura sobre concepções alternativas e abordou os seguintes temas: o ciclo dia-noite; os fusos horários; as estações do ano; as fases da Lua; o movimento da Lua; o movimento aparente do Sol na esfera celeste; os eclipses; as dimensões e distâncias no Universo; o brilho das estrelas e sua observação da Terra. Embora se tenha verificado um pequeno progresso na proporção de respostas cientificamente aceitáveis ao se cotejar a oitava série do Ensino Fundamental com a quinta, e a terceira série do Ensino Médio com a primeira, houve o predomínio de concepções alternativas em relação à maior parte dos temas explorados, as quais persistiram até o último ano da Educação Básica. A comparação com

  11. Analysis of the Presence of Content about Astronomy in a Decade of the National High School Examination (1998-2008). (Spanish Title: Análisis de la Presencia de Contenidos de Astronomía em Uma Década del Examen Nacional de Enseñaza Secundária (1998-2008).) Análise da Presença de Conteúdos de Astronomia em Uma DÉcada do Exame Nacional do Ensino Médio (1998-2008)

    NASA Astrophysics Data System (ADS)

    Gomide, Hanny Angeles; Longhini, Marcos Daniel

    2011-07-01

    In this paper we analyzed the presence of contents of Astronomy in the National High School Examination (ENEM) in its first decade (1998-2008). We verified the number of questions addressing this topic that were present over the years, as well as the most recurrent subjects. We discussed the results from what is proposed by the official documents regarding the teaching of Astronomy in the Elementary and Secondary Education and we entertain future expectations about the presence of contents of this science in future official examinations. En este trabajo realizamos un análisis de la presencia de contenidos de Astronomía em las pruebas del Examen Nacional de Enseñanza Secundaria (ENEM) em su primera década de existência (1998-2008). Contabilizamos la cantidad de preguntas incluyendo este tema que estuvieron presentes en el transcurso de los años, así como los temas más recurrentes. Discutimos los resultados a partir de lo propuesto por los documentos oficiales en relación a la enseñanza de Astronomía en la Educación Básica y elaboramos algunos apuntes sobre futuras expectativas em relación a la presencia de contenidos de esta ciencia en examenes oficiales. No presente trabalho fizemos uma análise da presença de conteúdos de Astronomia nas provas do Exame Nacional do Ensino Médio (ENEM), em sua primeira década de existência (1998-2008). Verificamos a quantidade de questões envolvendo essa temática que estiveram presentes no decorrer dos anos, assim como os temas mais recorrentes. Discutimos os resultados a partir do que é proposto pelos documentos oficiais em relação ao ensino de Astronomia na Educação Básica e tecemos alguns apontamentos sobre a expectativa futura quanto à presença de conteúdos dessa ciência nesse exame oficial.

  12. VizieR Online Data Catalog: TU UMa light curves and maxima, CL Aur minima (Liska+, 2016)

    NASA Astrophysics Data System (ADS)

    Liska, J.; Skarka, M.; Mikulasek, Z.; Zejda, M.; Chrastina, M.

    2016-02-01

    Differential photometry for RR Lyrae star TU UMa in the 1st and 2nd file. The measurements were obtained using 24-inch and 1-inch telescopes, respectively. The observations were performed at the Masaryk University Observatory in Brno (3 nights, 24-inch), and at the private observatory in Brno (16 nights, 1-inch) in the Czech Republic from December 2013 to June 2014. Observing equipments consisted of 24-inch Newtonian telescope (600/2780mm, diameter/focal length) and a Moravian Instruments CCD camera G2-4000 with Stromgren photometric filters vby, and of 1-inch refractor (a photographic lens Sonnar 4/135mm, lens focal ratio/focal length) and ATIK 16IC CCD camera with green photometric filter with similar throughput as the Johnson V filter. Exposures were v - 60s, b - 30s, y - 30s, green - 30s. For the small aperture telescope, five frames were combined to a single image to achieve a better signal-to-noise ratio. The time resolution of a such combined frame is about 170s. CCD images were calibrated in a standard way (dark frame and flat field corrections). The C-Munipack software (Motl 2009) was used for this processing as well as for differential photometry. The comparison star BD+30 2165 was the same for both instruments, but the control stars were BD+30 2164 (for the 24-inch telescope) and HD 99593 (for the 1-inch telescope). The 3rd file contains maxima timings of TU UMa adopted from the GEOS RR Lyr database, from the latest publications, together with maxima timings determined in our study. Times of maxima were calculated from our observations, sky-surveys data (Hipparcos, NSVS, Pi of the Sky, SuperWASP), photographic measurements (project DASCH), and from several published datasets, in which the maxima were omitted or badly determined - Boenigk (1958AcA.....8...13B), Liakos, Niarchos (2011IBVS.6099....1L, 2011IBVS.5990....1L), Liu, Janes (1989ApJS...69..593L), Preston et al. (1961ApJ...133..484P). The 4th file contains minima timings of eclipsing binary CL Aur

  13. Imagens do céu ontem e hoje - um multimídia interativo de astronomia e uma nova exposição no MAST

    NASA Astrophysics Data System (ADS)

    Caretta, C. A.; Lima, F. P.; Requeijo, F.; Vieira, G. G.; Alves, F.; Valente, M. E. A.; de Almeida, R.; de Garcia, G. C.; Quixadá, A. C.

    2003-08-01

    "Imagens do Céu Ontem e Hoje" é o título de uma nova exposição que está sendo inaugurada no Museu de Astronomia e Ciências Afins (MCT), que inclui experimentos interativos, maquetes, réplicas e 8 terminais de computador com um multimídia interativo sobre Astronomia para consulta dos visitantes. O multimídia apresenta um conteúdo bastante extenso, que engloba quase todos os temas em Astronomia, consistindo numa fonte de divulgação e pesquisa para um público que vai das crianças até estudantes universitários. O conteúdo está distribuído em mais de 500 páginas de texto divididas em 4 módulos: "O Universo", "Espectroscopia", "Telescópios" e "Observando o Céu". Cada módulo é subdividido em 5 seções, em média, cada uma iniciada por uma animação que ilustra os temas a serem abordados na seção. Ao final da animação, uma lista de temas é apresentada sob o título "Saiba Mais". Para exemplificar, o módulo "O Universo" contém as seguintes seções: "O Universo visto pelo homem", "Conhecendo o Sistema Solar", "Indo além do Sistema Solar", "Nossa Galáxia, a Via-Láctea" e "Indo mais além, a imensidão do Universo". A seção "Conhecendo o Sistema Solar", por sua vez, tem os seguintes temas: "A origem do Sistema Solar", "O Sol", "Os planetas", "Satélites, asteróides, cometas e outros bichos..." e "O Sistema Solar em números". Cada texto é repleto de imagens, quadros, desenhos, esquemas, etc, além de passatempos ao final de cada seção, incluindo jogos interativos, quadrinhos e curiosidades, que auxiliam o aprendizado de forma divertida. Apresentamos neste trabalho as idéias gerais que permearam a produção da exposição, e uma viagem pelo multimídia para exemplificar sua estrutura e conteúdo. O multimídia será posteriormente disponibilizado para o público externo pela página eletrônica do MAst e/ou por intermédio de uma publicação comercial.

  14. THE GEOMETRY AND IONIZATION STRUCTURE OF THE WIND IN THE ECLIPSING NOVA-LIKE VARIABLES RW TRI AND UX UMa

    SciTech Connect

    Noebauer, Ulrich M.; Long, Knox S.; Sim, Stuart A.; Knigge, Christian

    2010-08-20

    The UV spectra of nova-like variables are dominated by emission from the accretion disk, modified by scattering in a wind emanating from the disk. Here, we model the spectra of RW Tri and UX UMa, the only two eclipsing nova-like variables which have been observed with the Hubble Space Telescope in the far-ultraviolet, in an attempt to constrain the geometry and the ionization structure of their winds. Using our Monte Carlo radiative transfer code, we computed spectra for simply parameterized axisymmetric biconical outflow models and were able to find plausible models for both systems. These reproduce the primary UV resonance lines-N V, Si IV, and C IV-in the observed spectra in and out of eclipse. The distribution of these ions in the wind models is similar in both cases as is the extent of the primary scattering regions in which these lines are formed. The inferred mass-loss rates are 6%-8% of the mass accretion rates for the systems. We discuss the implication of our point models for our understanding of accretion disk winds in cataclysmic variables.

  15. Absolute parameter determination in low-mass eclipsing binaries - Radiative parameters for BH Vir, ZZ UMA and CR CAS

    NASA Astrophysics Data System (ADS)

    Clement, R.; Reglero, V.; Garcia, M.; Fabregat, J.; Bravo, A.; Suso, J.

    1993-01-01

    A new uvby and H-beta monitoring program of low mass eclipsing binaries is currently being carried out in the framework of a 5-yr observational program which also involves radial velocity determinations. The scope of this work is to provide very accurate absolute astrophysical parameters: mass, radius, and effective temperatures, for main-sequence late-type stars. One of the main goals is to improve the mass-luminosity relation in the low and intermediate mass range. A second objective is to perform accurate tests of the most recent grids of evolutionary models. This program is complementary to that currently being implemented by the Copenhagen group. In this contribution we present the photometric preliminary results obtained for three of the systems included in our long-term survey: BH Vir, ZZ UMa, and CR Cas for which primary eclipses have been observed. Particular attention is paid to the determination of reddening, distances, and radiative properties. A more detailed study will be carried out when the light curves and radial velocity measurements are completed.

  16. The first photometric investigation and orbital period variation analysis of the W UMa type binary IK Bootis

    NASA Astrophysics Data System (ADS)

    Kriwattanawong, Wichean; Sanguansak, Nuanwan; Maungkorn, Sakdawoot

    2017-08-01

    With new CCD observations of the W UMa type binary IK Boo, we present the first investigation of photometric parameters and orbital period change. The BVRc light curve fit shows that IK Boo is a W-type contact system with a mass ratio of q = 1.146 and a shallow contact with a fill-out factor of f = 2.22%. The orbital period decrease was found to be a rate of -3.28 × 10-7 d yr-1, corresponding to a mass transfer from the more massive to the less massive component with a rate of -2.83 × 10-6 M⊙ yr-1. The inner and outer critical Roche lobes will contract and cause the contact degree to increase. Therefore, IK Boo may evolve into a deeper contact system. Furthermore, a possible cyclic variation was found with a period of 9.74 yr, which could be explained by the light-travel time effect due to the existence of a third companion in the system.

  17. Optimization of Physiochemical Parameters during Bioremediation of Synthetic Dye by Marasmius cladophyllus UMAS MS8 Using Statistical Approach

    PubMed Central

    Shuib, Fatin Nur Sufinas

    2016-01-01

    In many industrial areas such as in food, pharmaceutical, cosmetic, printing, and textile, the use of synthetic dyes has been integral with products such as azo dye, anthrax, and dyestuffs. As such, these industries produce a lot of waste by-products that could contaminate the environment. Bioremediation, therefore, has become an important emerging technology due to its cost-sustainable, effective, natural approach to cleaning up contaminated groundwater and soil via the use of microorganisms. The use of microorganisms in bioremediation requires the optimisation of parameters used in cultivating the organism. Thus the aim of the work was to assess the degradation of Remazol Brilliant Blue R (RBBR) dye on soil using Plackett-Burman design by the basidiomycete, M. cladophyllus UMAS MS8. Biodegradation analyses were carried out on a soil spiked with RBBR and supplemented with rice husk as the fungus growth enhancer. A two-level Plackett-Burman design was used to screen the medium components for the effects on the decolourization of RBBR. For the analysis, eleven variables were selected and from these four parameters, dye concentration, yeast extract concentration, inoculum size, and incubation time, were found to be most effective to degrade RBBR with up to 91% RBBR removal in soil after 15 days. PMID:27803944

  18. ASCA Observation of a Long-Duration X-Ray Flare from the W UMa--Type Binary VW Cephei

    NASA Astrophysics Data System (ADS)

    Choi, C. S.; Dotani, T.

    1998-01-01

    We analyze X-ray archive data of the W UMa-type binary VW Cephei taken with ASCA on 1993 November 5-6. By analyzing the light curve, we find a long-duration flare of ~7.5 hr with a peak luminosity of 1.2 × 1030 ergs s-1 (0.4-3.0 keV) for the assumed distance of 23.2 pc. A flux dip is detected in the light curve at the orbital phase of ~0.5, and it is identified as an eclipse by the secondary star. We determine the timescale of the eclipse egress to be ~30 minutes from a model fit to the light curve. With this timescale, we estimate that the linear size of the flaring region is ~5.5 × 1010 cm, regardless of the flare models. From the spectral analysis of the data, we find that the spectrum can be well reproduced by the variable-abundance plasma model with a combination of two different temperatures, kT = 0.64 and kT = 1.91 keV. The hotter component is considered to be associated with the flare. The results are interpreted in terms of a two-ribbon flare model, in which we also discuss the possible enhancement of element abundances.

  19. Speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a species of conservation concern

    PubMed Central

    Gottscho, Andrew D; Marks, Sharyn B; Jennings, W Bryan

    2014-01-01

    The North American deserts were impacted by both Neogene plate tectonics and Quaternary climatic fluctuations, yet it remains unclear how these events influenced speciation in this region. We tested published hypotheses regarding the timing and mode of speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), a sand dune specialist endemic to the Mojave Desert of California and Arizona. We sampled 109 individual lizards representing 22 insular dune localities, obtained DNA sequences for 14 nuclear loci, and found that U. scoparia has low genetic diversity relative to the U. notata species complex, comparable to that of chimpanzees and southern elephant seals. Analyses of genotypes using Bayesian clustering algorithms did not identify discrete populations within U. scoparia. Using isolation-with-migration (IM) models and a novel coalescent-based hypothesis testing approach, we estimated that U. scoparia diverged from U. notata in the Pleistocene epoch. The likelihood ratio test and the Akaike Information Criterion consistently rejected nested speciation models that included parameters for migration and population growth of U. scoparia. We reject the Neogene vicariance hypothesis for the speciation of U. scoparia and define this species as a single evolutionarily significant unit for conservation purposes. PMID:25360285

  20. First BVR light curves and preliminary results of a recently discovered W UMa-type binary: V1848 Ori

    NASA Astrophysics Data System (ADS)

    Kriwattanawong, W.; Poojon, P.

    2014-04-01

    First complete photometric light curves of a recently discovered contact binary, V1848 Ori, are presented. BVR imaging data were used to derive photometric solutions, using Wilson-Devinney code. We discovered that this system is a weak-contact binary, with a fillout factor of f = 13.14%(±1.44%). Preliminary results showed that V1848 Ori is an A-type W UMa system, with a mass ratio of q = 0.7615. The more massive component was found about 400 K hotter than the other one. This system has varied from W-type to A-type during the last decade. According to the preliminary physical parameters, the weak-contact configuration of this system, with the mass ratio close to unity, and no sign of long-term orbital period change yet, is unlikely to be broken. The contact configuration is expected to be maintained and become deeper or not, depending on effect of the AML mechanism.

  1. VRI photometry and light curve analysis of short period W UMa-Type 1SWASP J222514.69 + 361643.0

    NASA Astrophysics Data System (ADS)

    El-Depsey, M. H.; Abo-Alazm, M. S.; Saad, M. S.; Hassan, I. A.; Shaltout, A. M. K.; Zeid, I.; Shokry, A.; Darwish, M.

    2017-10-01

    We present the first light curve analysis and modeling for the short period close binary 1SWASP J222514.69 + 361643.0. The results show that the system is in over contact with factor ƒ = 53%. The primary component is the massive and hotter one. The system is A-subtype W UMa eclipsing binary with spectral types K2 and K3, respectively.

  2. [Epidemiology of bilio-pancreatic cancer in Specialty Hospital UMAE N°71 IMSS in Torreón, Coahuil].

    PubMed

    Güitrón-Cantú, A; Adalid-Martínez, R; Segura-López, Fk

    2011-01-01

    There is a worldwide increase in the incidence of cancer of the biliopancreatic ducts; early diagnosis is difficult and prognosis is poor. To analyze the frequency of malignant biliary strictures diagnosed by Endoscopio Retrograde Cholangiopancreatography (ERCP) at the "Hospital de Especialidades No. 71 UMAE IMSS", Torreon, Coahuila, Mexico. A 5-year retrospective study of consecutive patients referred for ERCP at our institution was performed. Medical records from patients with malignant neoplasms were reviewed. Demographic variables, post-ERCP and final diagnosis, based on cytological and endoscopic or surgical biopsies, imaging studies and clinical outcome were registered. The frequency of biliary-pancreatic neoplasm was 15.6% (301 cases in 1924 ERCP) determined by bile duct cancer (40.7%), pancreas (27.9%) and Vater´s ampulla (12.3%). Brushing was performed for histopathological analysis in 86.7% of cases. The cytology was positive in 91.2%, negative 8.8%, and it was no possible in 13.3% of cases. Therapeutic endoscopy was performed in 273 patients with complications in 1.3% and no procedure-related mortality. Patients with malignant strictures had a higher risk for unsuccessful ERCP (RR 3.01, 95% CI 1.77 - 5.11) and carrying out pre-cut sphincterotomy (RR 1.80, 95% CI 1.38 - 2.35). In our center the incidence of biliary-pancreatic neoplasm was 15.6% among patients sent to ERCP and its presence increases the degree of difficulty in performing diagnostic and therapeutic endoscopic procedures.

  3. Environmental differences in substrate mechanics do not affect sprinting performance in sand lizards (Uma scoparia and Callisaurus draconoides).

    PubMed

    Korff, Wyatt L; McHenry, Matthew J

    2011-01-01

    Running performance depends on a mechanical interaction between the feet of an animal and the substrate. This interaction may differ between two species of sand lizard from the Mojave Desert that have different locomotor morphologies and habitat distributions. Uma scorparia possesses toe fringes and inhabits dunes, whereas the closely related Callisaurus draconoides lacks fringes and is found on dune and wash habitats. The present study evaluated whether these distribution patterns are related to differential locomotor performance on the fine sand of the dunes and the course sand of the wash habitat. We measured the kinematics of sprinting and characterized differences in grain size distribution and surface strength of the soil in both habitats. Although wash sand had a surface strength (15.4±6.2 kPa) that was more than three times that of dune sand (4.7±2.1 kPa), both species ran with similar sprinting performance on the two types of soil. The broadly distributed C. draconoides ran with a slightly (22%) faster maximum speed (2.2±0.2 m s(-1)) than the dune-dwelling U. scorparia (1.8±0.2 m s(-1)) on dune sand, but not on wash sand. Furthermore, there were no significant differences in maximum acceleration or the time to attain maximum speed between species or between substrates. These results suggest that differences in habitat distribution between these species are not related to locomotor performance and that sprinting ability is dominated neither by environmental differences in substrate nor the presence of toe fringes.

  4. Queda dos homicídios em São Paulo, Brasil: uma análise descritiva

    PubMed Central

    Peres, Maria Fernanda Tourinho; Vicentin, Diego; Nery, Marcelo Batista; de Lima, Renato Sérgio; de Souza, Edinilsa Ramos; Cerda, Magdalena; Cardia, Nancy; Adorno, e Sérgio

    2012-01-01

    Objetivo Descrever a evolução da mortalidade por homicídios no Município de São Paulo segundo tipo de arma, sexo, raça ou cor, idade e áreas de exclusão/inclusão social entre 1996 e 2008. Métodos Estudo ecológico de série temporal. Os dados sobre óbitos ocorridos no Município foram coletados da base de dados do Programa de Aprimoramento das Informações sobre Mortalidade, seguindo a Classificação Internacional de Doenças, Décima Revisão (CID-10). Foram calculadas as taxas de mortalidade por homicídio (TMH) para a população total, por sexo, raça ou cor, faixa etária, tipo de arma e área de exclusão/inclusão social. As TMH foram padronizadas por idade pelo método direto. Foram calculados os percentuais de variação no período estudado. Para as áreas de exclusão/inclusão social foram calculados os riscos relativos de morte por homicídio. Resultados As TMH apresentaram queda de 73,7% entre 2001 e 2008. Foi observada redução da TMH em todos os grupos analisados, mais pronunciada em homens (−74,5%), jovens de 15 a 24 anos (−78,0%) e moradores de áreas de exclusão social extrema (−79,3%). A redução ocorreu, sobretudo, nos homicídios cometidos com armas de fogo (−74,1%). O risco relativo de morte por homicídio nas áreas de exclusão extrema (tendo como referência áreas com algum grau de exclusão social) foi de 2,77 em 1996, 3,9 em 2001 e 2,13 em 2008. Nas áreas de alta exclusão social, o risco relativo foi de 2,07 em 1996 e 1,96 em 2008. Conclusões Para compreender a redução dos homicídios no Município, é importante considerar macrodeterminantes que atingem todo o Município e todos os subgrupos populacionais e microdeterminantes que atuam localmente, influenciando de forma diferenciada os homicídios com armas de fogo e os homicídios na população jovem, no sexo masculino e em residentes em áreas de alta exclusão social. PMID:21390415

  5. BVRI Photometric Study of the Short Period Solar Type Near-Contact W UMa Binary, FF Vulpeculae

    NASA Astrophysics Data System (ADS)

    Caton, Daniel B.; Samec, Ronald G.; Nyaude, Ropafadzo; Van Hamme, Walter V.

    2016-01-01

    High precision BVRcIc light curves of FF Vul were observed during the Fall, 2015 season at the Dark Sky Observatory 0.81-m reflector of Appalachian State University, and the SARA North 0.91-m reflector at KPNO. It is an eclipsing binary with a period of only 0.444983 (2) d. This is the shortest period of our recently studied Pre Contact W UMa Binary (PCWB's), V2421 Cyg, V1043 Cas, ZZ Eri, V500 Peg, and Mis V1287. Our Binary Maker fits and our Wilson-Devinney solution show that the binary is a near-contact, semidetached binary, i.e., a V1010 Oph type configuration (the more massive component has filled its critical lobe while the secondary component is under-filling). Five times of minimum light were calculated, 3 primary and 2 secondary eclipses from our present observations:HJD I = 2457285.7262 ±0.0002, 2457306.6425 ±0.0002, 2457310.6469 ±0.0002HJD II = 2457279.7222 ±0.0006, 2457280.6124 ±0.0017.The following quadratic ephemerides was determined from all available times of minimum light:JDHelMinI=2457310.6473±0.0007d + 0.4449758±0.0000002 X E -0.00000000006± 0.00000000001 X E2The continuous 20 year period study reveals a period decrease in the orbital period at about the 6 sigma level. Our modeling shows a near-equatorial hot spot on the following side of the secondary component. This is probably due to a matter transfer onto the secondary component. The light curve has a large difference in primary and secondary amplitudes and the light curve solution gives a component temperature difference of more than 1500 K. The solution shows a total secondary eclipse of 23 minutes duration. As expected in binaries of this type, it has a cool spot region on its primary component.

  6. Uma comparação entre técnicas de propagação de erros em astrofísica: Monte Carlo x Bootstrap

    NASA Astrophysics Data System (ADS)

    Waelkens, A. H.; Janot Pacheco, E.

    2003-08-01

    Recentemente Dhillon & Watson (2001) criticaram o procedimento de determinação de erros via simulações de Monte Carlo no caso do imageamento indireto de estrelas, por introduzir ruído nos dados e resultar em erros superestimados. Estes autores propuseram a utilização alternativa do método de Bootstrap como uma técnica superior para a estimativa de erros. Neste trabalho apresentamos os resultados de um estudo comparativo da performance das técnicas de simulação por Monte Carlo e por Bootstrap para a determinação de erros em duas situações de interesse: (i) ajuste de modelos a espectros observados e (ii) imageamento indireto de discos de acréscimo com técnicas de mapeamento por eclipse. No caso (i), os dados de entrada são espectros de emissão simples de hidrogênio aos quais é adicionado ruído gaussiano de amplitude selecionada. No caso (ii), são produzidas curvas de luz do eclipse de uma distribuição de brilho seguindo a lei TµR-3/4 para discos estacionários cuja taxa de acréscimo varia ao longo do eclipse segundo uma distribuição gaussiana de amplitude selecionada, simulando o ruído. A avaliação da performance é feita com o auxílio de um diagrama do erro relativo na grandeza ajustada, conforme obtido por cada método, versus o erro relativo (ruído/sinal) dos dados de entrada. O estudo mostra que as duas técnicas produzem resultados semelhantes nos dois casos, e que a suposta superioridade do método de Bootstrap não se confirma.

  7. Rapid Light-curve Changes and Probable Flip-flop Activity of the W UMa-type Binary V410 Aur

    NASA Astrophysics Data System (ADS)

    Luo, Xia; Wang, Kun; Zhang, Xiaobin; Deng, Licai; Luo, Yangping; Luo, Changqing

    2017-09-01

    New photometric observations of a W UMa system, V410 Aur, were carried out over 10 nights from 2014 December 19 to 2015 February 8, from which four sets of light curves were obtained. The light curves show many unusual behavioral features, including changing occultation depths, transit minima, and asymmetric maxima. The four sets of light curves have been separately analyzed with the Wilson-Devinney method. The results suggest a totally eclipsing contact configuration for the system. Over a surprisingly short time span of only 52 days, the dominant spot distortion phase jumped twice between phases 0.0 and 0.5. The light-curve variations can be interpreted by the presence of two cool spots on the massive component. Based on our analysis, it is further suggested that the peculiar behavioral patterns are probably caused by the presence of two permanent, active large spots separated in longitude by about 180°, whose locations remain almost unchanged throughout. Our study demonstrates that the system has been undergoing typical flip-flop activity. We therefore conclude that V410 Aur is a W UMa-type system exhibiting flip-flop activity.

  8. Photometric observations and Numerical modeling of SDSS J162520.29+120308.7, an SU UMa in the CV period gap

    NASA Astrophysics Data System (ADS)

    Montgomery, M. M.; Voloshina, I.; Olenick, Richard; Meziere, Kyle; Metlov, Vladimir

    2017-01-01

    We present R-band photometric observations of Cataclysmic Variable dwarf nova SU UMa SDSS J162520.29+120308.7 during the July 2010 superoutburst, from near maximum through decline and into a single rebrightening. We find a maximum superoutburst amplitude of ∼ 6.1 magnitudes and a maximum rebrightening amplitude of ∼4 magnitudes. Near superoutburst maximum, we find 0.09604(3) days for the mean Stage B positive superhump period and a much longer period for the hump shaped modulation during the rebrightening. For the orbital period, we find Porb = 0.09113(30) days. As all periods both agree and disagree with values reported by others, additional observations are needed. Our 2015 observations of this system in quiescence reveal a 0.09080(20) day orbital period. As our 2010 value is within the error bars of a spectroscopically determined value and our 2015 photometrically determined value, we suggest 0.09113(30) days as the orbital period for this system. As for the secondary-to-primary mass ratio, analytical models using observed orbital and Stage B positive superhump periods as input suggest q = 0.221. As a check, we present a 3D SPH simulation of the rise to, and during the plateau stage of, the SU UMa in superoutburst, assuming Porb=0.09113 days. For Stages A and B, we find 0.09717 days and 0.09702 days, respectively, for the average simulated positive superhump periods. Analytical models using these simulated Stages A and B and the simulated orbital period suggest q = 0.1920(4) and q = 0.221, respectively, for this system. Due to the poorly constrained observational data and the similar mass ratio estimates regardless of stage, we can neither confirm nor deny that Stage A is better than Stage B for determining mass ratio in CV dwarf novae SU UMa systems. Additional observations and simulations are needed to further test this recently proposed hypothesis. For now, we suggest an average q = 0.21(1) for this system.

  9. Volatiles in gases and melt inclusions erupted during the 2008-9 Halema`uma`u eruption of Kilauea Volcano, Hawai`i

    NASA Astrophysics Data System (ADS)

    Sawyer, G. M.; Sides, I.; Martin, R.; Mead, I.; Roberts, T. J.; Jones, R.; Tsanev, V. I.; Herd, R.; Sutton, A. J.; Elias, T.; Werner, C. A.; Swanson, D.; Allard, P.; Oppenheimer, C.; Edmonds, M.

    2009-12-01

    Parental magmas ascending beneath Kilauea Volcano degas volatile species in the order of their solubility, with deep degassing (up to a few tens of kilometres depth) dominated by carbon dioxide and shallow degassing (less than 1 km depth), by water and sulphur gases. The 2008-9 Halema`uma`u eruption provides a unique opportunity to measure the composition of primary, unfractionated volcanic gas as part of a young and highly concentrated plume, using new miniature gas sensors. The eruption also offers a chance to test models of volatile fractionation and degassing at Kilauea that were originally proposed a quarter century ago and, in doing so, extend our understanding of magma and degassing pathways at this long-lived and well-studied volcano. In April 2009, the composition of volcanic gas was measured by non-dispersive infra-red spectrometers, electrochemical sensors and FTIR spectroscopy on the Halema`uma`u crater rim. CO2 concentration was measured by two 21 cm-pathlength miniature NDIR spectrometers, deployed side by side. SO2, H2S and CO concentrations were measured simultaneously by an array of electrochemical sensors adjacent to the CO2 sensors. Sampling rates of ~1 Hz were achieved on all sensors. The data sets were cross-correlated with one another and gas ratios derived for the summit gas plume. Open-path active source FTIR measurements carried out close to the sensors yielded independent ratios between the major volatile species. Tephra erupted from the new Halema`uma`u vent in September 2008 was sampled, and olivine-hosted melt inclusions were isolated and exposed for analysis by electron microprobe and SIMS for major elements and volatile species. We present S, Cl, F, H2O and CO2 concentrations in melt inclusions and matrix glasses, as well as major and trace element data, in order to establish degassing and melt evolution trends. We compare the data to those collected previously for East Rift eruptions, for the Summit plume during rift eruptions, for

  10. Evidence for gas accumulation beneath the surface crust driving cyclic rise and fall of the lava surface at Halema`uma`u, Kilauea Volcano

    NASA Astrophysics Data System (ADS)

    Patrick, M. R.; Orr, T. R.; Wilson, D.; Sutton, A. J.; Elias, T.; Fee, D.; Nadeau, P. A.

    2010-12-01

    The ongoing eruption in Halema`uma`u crater, at the summit of Kilauea Volcano, has surpassed the two-year mark and is characterized by lava lake activity in the vent. As of August 2010, the lava lake is about 70 m in diameter and 180 m below the rim of a narrow vent cavity. Although the explosive events that typified the first year of activity have abated, episodic rise and fall of the lava surface remains common. Cycles of rise and fall range from several minutes to eight hours in duration and are characterized by a quiescent rise phase and violent, gas-charged fall, spanning a height change of 20-30 m. Several models have been proposed to explain the cyclic rise and fall of lava surfaces at basaltic volcanoes, which in some cases is referred to as “gas pistoning”. In one model, episodic rise and fall is driven by the ascent of gas slugs from depth. In another, the cyclic behavior is driven by gas accumulation beneath the surface crust, with each cycle terminated by an abrupt failure of the crust, resulting in gas release. Seismic and infrasound data, as well as gas and webcam monitoring, at Halema`uma`u over the past two years strongly support the gas accumulation model, based on several lines of evidence. First, gas emission rates drop significantly below background levels during the rise phase, and increase dramatically during the fall phase, suggesting a process of gas buildup and release as opposed to slug flow. Second, the rise phases can last several hours, which is longer than reasonable slug ascent times. Third, the rise rate decreases over time, and in many cases plateaus, as the lava reaches its high stand, which is contrary to the exponential increase expected for gas slugs. Fourth, webcam video has captured numerous instances where rockfalls piercing the surface crust initiate gas release and lava level drop, suggestive of gas accumulation at shallow levels. Lastly, FTIR (Fourier Transform Infrared Spectroscopy) data reveal changes in gas

  11. BVR{sub c}I{sub c} OBSERVATIONS AND ANALYSES OF THE DWARF DETACHED BINARY V1043 CASSIOPEIA AND A COMMENT ON PRECONTACT W UMa'S

    SciTech Connect

    Samec, R. G.; Smith, P. M.; Chamberlain, H.; Faulkner, D. R.; Van Hamme, W.

    2013-01-01

    Complete Bessel BVR{sub c}I{sub c} light curves of V1043 Cassiopeia [2MASS J00371195+5301324, Mis V1292, USNO-A2.0 1425-00875743, {alpha}(2000) = 00{sup h}37{sup m}11.{sup s}95, {delta}(2000) = +53 Degree-Sign 01'32.''5] are analyzed. The system is a member of the small group of pre-contact W UMa binaries (PCWBs). Its light curve has the appearance of an Algol (EA) light curve, however it is made up of dwarf solar type components in a detached mode with a period of only 0.6616 days. The analysis includes a period study, an improved ephemeris, a mass ratio search, and a simultaneous BVR{sub c}I{sub c} Wilson-Devinney solution. We document about 20 other PCWBs given in the literature. Several have RS CVn-like properties.

  12. Photometric observations and light curve solutions of the W UMa stars NSVS 2244206, NSVS 908513, CSS J004004.7+385531 and VSX J062624.4+570907

    NASA Astrophysics Data System (ADS)

    Kjurkchieva, Diana Petrova; Popov, Velimir Angelov; Vasileva, Doroteya Lyubenova; Petrov, Nikola Ivanov

    2016-09-01

    Photometric observations in Sloan g‧ and i‧ bands of four W UMa stars, NSVS 2244206, NSVS 908513, CSS J004004.7+385531 and VSX J062624.4+570907, are presented. The light curve solutions reveal that all targets have overcontact configurations with fillout factors within 0.15-0.26. Their components are G-K spectral types and are almost in thermal contact. They are also relatively close in size and luminosity: the radius ratios r2/r1 are within 0.75-0.90 the luminosity ratios l2/l1 are within 0.53-0.63. The results of the light curve solution of CSS J004004.7+385531 imply the weak limb-darkening effect of its primary component and possible presence of additional absorbing features in the system.

  13. Electronic structure of bulk AnO2 (An = U, Np, Pu) and water adsorption on the (111) and (110) surfaces of UO2 and PuO2 from hybrid density functional theory within the periodic electrostatic embedded cluster method

    NASA Astrophysics Data System (ADS)

    Wellington, Joseph P. W.; Kerridge, Andrew; Austin, Jonathan; Kaltsoyannis, Nikolas

    2016-12-01

    Generalised gradient approximation (PBE) and hybrid (PBE0) density functional theory (DFT) within the periodic electrostatic embedded cluster method have been used to study AnO2 bulk and surfaces (An = U, Np, Pu). The electronic structure has been investigated by examining the projected density of states (PDOS). While PBE incorrectly predicts these systems to be metallic, PBE0 finds them to be insulators, with the composition of the valence and conduction levels agreeing well with experiment. Molecular and dissociative water adsorption on the (111) and (110) surfaces of UO2 and PuO2 has been investigated, with that on the (110) surface being stronger than on the (111). Similar energies are found for molecular and dissociative adsorption on the (111) surfaces, while on the (110) there is a clear preference for dissociative adsorption. Adsorption energies and geometries on the (111) surface of UO2 are in good agreement with recent periodic DFT studies using the GGA+U approach, and our data for dissociative adsorption on the (110) surface of PuO2 match experiment rather well, especially when dispersion corrections are included.

  14. Lineage diversification of fringe-toed lizards (Phrynosomatidae: Uma notata complex) in the Colorado Desert: Delimiting species in the presence of gene flow

    USGS Publications Warehouse

    Gottscho, Andrew D.; Wood, Dustin A.; Vandergast, Amy; Lemos Espinal, Julio A.; Gatesy, John; Reeder, Tod

    2017-01-01

    Multi-locus nuclear DNA data were used to delimit species of fringe-toed lizards of theUma notata complex, which are specialized for living in wind-blown sand habitats in the deserts of southwestern North America, and to infer whether Quaternary glacial cycles or Tertiary geological events were important in shaping the historical biogeography of this group. We analyzed ten nuclear loci collected using Sanger sequencing and genome-wide sequence and single-nucleotide polymorphism (SNP) data collected using restriction-associated DNA (RAD) sequencing. A combination of species discovery methods (concatenated phylogenies, parametric and non-parametric clustering algorithms) and species validation approaches (coalescent-based species tree/isolation-with-migration models) were used to delimit species, infer phylogenetic relationships, and to estimate effective population sizes, migration rates, and speciation times. Uma notata, U. inornata, U. cowlesi, and an undescribed species from Mohawk Dunes, Arizona (U. sp.) were supported as distinct in the concatenated analyses and by clustering algorithms, and all operational taxonomic units were decisively supported as distinct species by ranking hierarchical nested speciation models with Bayes factors based on coalescent-based species tree methods. However, significant unidirectional gene flow (2NM >1) from U. cowlesi and U. notata into U. rufopunctata was detected under the isolation-with-migration model. Therefore, we conservatively delimit four species-level lineages within this complex (U. inornata, U. notata, U. cowlesi, and U. sp.), treating U. rufopunctata as a hybrid population (U. notata x cowlesi). Both concatenated and coalescent-based estimates of speciation times support the hypotheses that speciation within the complex occurred during the late Pleistocene, and that the geological evolution of the Colorado River delta during this period was an important process shaping the observed phylogeographic patterns.

  15. Lineage diversification of fringe-toed lizards (Phrynosomatidae: Uma notata complex) in the Colorado Desert: Delimiting species in the presence of gene flow.

    PubMed

    Gottscho, Andrew D; Wood, Dustin A; Vandergast, Amy G; Lemos-Espinal, Julio; Gatesy, John; Reeder, Tod W

    2017-01-01

    Multi-locus nuclear DNA data were used to delimit species of fringe-toed lizards of the Uma notata complex, which are specialized for living in wind-blown sand habitats in the deserts of southwestern North America, and to infer whether Quaternary glacial cycles or Tertiary geological events were important in shaping the historical biogeography of this group. We analyzed ten nuclear loci collected using Sanger sequencing and genome-wide sequence/single-nucleotide polymorphism (SNP) data collected using restriction-associated DNA (RAD) sequencing. A combination of species discovery methods (concatenated phylogenies, parametric and non-parametric clustering algorithms) and species validation approaches (coalescent-based species tree/isolation-with-migration models) were used to delimit species, infer phylogenetic relationships, and to estimate effective population sizes, migration rates, and speciation times. Uma notata, U. inornata, U. cowlesi, and an undescribed species from Mohawk Dunes, Arizona (U. sp.) were supported as distinct in the concatenated analyses and by clustering algorithms, and all operational taxonomic units were decisively supported as distinct species by ranking hierarchical nested speciation models with Bayes factors based on coalescent-based species tree methods. However, significant unidirectional gene flow (2NM>1) from U. cowlesi and U. notata into U. rufopunctata was detected under the isolation-with-migration model. Therefore, we conservatively delimit four species-level lineages within this complex (U. inornata, U. notata, U. cowlesi, and U. sp.), treating U. rufopunctata as a hybrid population (U. notata×cowlesi). Both concatenated and coalescent-based estimates of speciation times support the hypotheses that speciation within the complex occurred during the late Pleistocene, and that the geological evolution of the Colorado River delta during this period was an important process shaping the observed phylogeographic patterns.

  16. Management of fistula-in-ano: an introduction.

    PubMed

    El-Tawil, Am

    2011-07-28

    Peri-anal fistulae are a worldwide health problem that can affect any person anywhere. Surgical management of these fistulae is not free from risks. Recurrence and fecal incontinence are the most common complications after surgery. The cumulative personal surgical experience in managing cases with anal fistulae is significantly considered as necessary for obtaining better results with minimal adverse effects after surgery. The purpose for conducting this survey is to facilitate better outcome after surgical interventions in idiopathic anal fistulae' cases.

  17. Ano-Rectal Symptoms of Sexually Transmitted Disease

    PubMed Central

    Warren, Ralph E.

    1987-01-01

    Diseases of the anus and rectum are frequently the outcome of proctogenital and oral-anal sexual activities. These sexually transmitted diseases are more common among homosexual and bisexual men than among heterosexuals. A variety of infectious agents are responsible including viruses, bacteria, spirochetes, helminths, and protozoa. Anal warts, herpetic ulcers, and syphilitic chancres are common anal STDs. Gonorrhea, herpes, and chlamydial organisms are common causes of venereal acute proctitis. Enteric infections such as shigellosis, amebiasis, giardiasis and pinworms can be transmitted by oral-anal contact. Aggressive sexual attempts at auto-eroticism using rectally inserted foreign bodies may cause traumatic proctitis complicated by bacterial peritonitis or perirectal abscesses. PMID:21263807

  18. Detecção da fase impulsiva de uma explosão solar gigante até 405 GHz

    NASA Astrophysics Data System (ADS)

    Raulin, J.-P.; Makhmutov, V.; Kaufmann, P.; Pacini, A. A.; Luethi, T.; Hudson, H. S.; Gary, D. E.; Yoshimori, M.

    2003-08-01

    A explosão ocorrida no dia 25/08/2001 foi uma das mais intensas do presente ciclo solar em ondas de rádio de altas frequências. Foram medidas em ondas milimétricas e submilimétricas, aproximadamente, 105 e vários milhares de unidades de fluxo solar, respectivamente. Apresentamos um estudo deste evento em múltiplas frequências, desde microondas (1GHz), até ondas submilimétricas (405 GHz) detectadas pelo Telescópio Solar para ondas Submilimétricas (SST). Esta base de dados foi complementada utilizando-se o experimento Yohkoh, incluindo a emissão em raios-X duros e raios-g (até 100 MeV), e imagens em raios-X moles da região ativa envolvida. Enfocamos e discutimos principalmente os seguintes aspectos da fase impulsiva do evento: (i) as implicações deduzidas do espectro eletromagnético, obtido pela primeira vez até 405 GHz; (ii) a dinâmica da região ativa. Os resultados mostram que para explicar o espectro rádio observado, são necessários entre 3.5×1037 e 1.5×1039 elétrons acelerados acima de 20 keV em uma região de campo magnético entre 300 e 800 Gauss. A estimativa do fluxo de fótons que seria produzido por estes elétrons, mostra que grande parte deles não precipitou na baixa atmosfera. A evolução temporal da emissão em raios-X moles revela que a configuração magnética da região ativa foi muito dinâmica durante a fase impulsiva da explosão. Em particular, mostramos que a produção dos elétrons altamente energéticos foi iniciada junto com a aparição, na baixa coroa solar, de um novo sistema compacto de estruturas magnéticas. Este fato sugere que os locais de aceleração estão localizados na baixa atmosfera do Sol, como resultado da interação entre o novo sistema compacto e o campo magnético ambiente da região ativa.

  19. Analysis of the southern pre-contact W UMa binary ZZ Eridani: A 34 year period study yields a possible low-mass companion

    SciTech Connect

    Samec, R. G.; Clark, J. D.; Hamme, W. Van; Faulkner, D. R.

    2015-02-01

    Complete Bessel BVRI light curves of ZZ Eridani [2MASS J04130109-1044545, HV 6280, NSVS 14888164 α(2000) = 04{sup h}13{sup m}1{sub ·}{sup s}10, δ(2000) = −10°44′54{sub ·}{sup ″}5 (ICRS), V = 13.9-14.4-15.0] are observed and analyzed. The system is a southern pre-contact W UMa binary. Its light curve has the appearance of an Algol (EA) light curve, however, it is made up of dwarf solar-type components with a period of only 0.4521 days. Our 34 year period study yields a sinusoidal fit or an increasing quadratic fit. The sinusoid may indicate that a third body is orbiting the close binary. The lower-limit mass of the third body is near that of the brown dwarf limit (0.095 M α). Also included is an improved ephemeris, a mass ratio search, and a simultaneous BVRI Wilson–Devinney solution.

  20. Vesiculation Processes During Transient and Sustained Explosive Activity at Halema'uma'u Crater, Kīlauea in 2008-2013.

    NASA Astrophysics Data System (ADS)

    Houghton, B. F.; Orr, T. R.; Taddeucci, J.; Carey, R.; Del Bello, E.; Scarlato, P.; Patrick, M. R.

    2015-12-01

    The 2008-2015 summit eruption within Halema'uma'u crater, Kilauea has been characterized by alternations of passive degassing with two styles of explosive activity, both frequently triggered by rock falls that perturb the free surface of magma in the vent. In the first, larger rock falls trigger second vesiculation of magma at depths up to 100 m below the free surface ejecting juvenile bomb and lapilli populations of very variable vesicularity. The second, the topic of this presentation, consists of intervals of minutes to tens-of-minutes duration of low fountaining activity often from multiple locations. Vents may migrate with time, first across the free surface to its margins, and then around the margins, in response to convection processes in the underlying melt. Analysis of short sequences of high-speed, high-resolution video footage shows that the sustained fountaining is maintained by not by a continuous discharge but rather by closely spaced bursting of two-to-five meter-wide bubbles. Bubbles accelerate through the free surface at velocities of 10 to 40 m/s disrupting the viscoelastic crust and forming large fall-back, lacework pyroclasts and smaller highly vesicular bombs and lapilli.

  1. Adapting a Common Photographic Camera to Take Pictures of the Sky. (Spanish Title: Adaptando Una Camara Fotografica Comun Para Obtener Fotografias del Cielo.) Adaptando Uma Câmera Fotográfica Manual Simples Para Fotografar o Céu

    NASA Astrophysics Data System (ADS)

    Danhoni Neves, Marcos Cesar; Pereira, Ricardo Francisco

    2007-12-01

    In this paper will be introduced a method of astrophotography using a non-reflex photographic camera (a low-cost method). It will be revised some photographic processes commonly used nowadays for comparison with the aims of this paper. En este trabajo será introducido un método de astrofotografia que utiliza una cámara fotográfica non-reflex (un método de bajo costo). Serán revisados algunos procesos fotográficos comúnmente utilizados actualmente para comparación con los objetivos de este trabajo. O presente artigo procura introduzir um método de astrofotografia utilizando uma câmera fotográfica não reflex, de baixo custo. É feita uma revisão do processo fotográfico comumente empregado para fins de comparação com os objetivos pretendidos no presente trabalho.

  2. Ambient air quality effects of the 2008-2009 Halema`uma`u eruption on the Island of Hawai`i

    NASA Astrophysics Data System (ADS)

    Elias, T.; Sutton, A. J.; Kauahikaua, J. P.; Ray, J. D.; Babb, J. L.

    2009-12-01

    While the Halema`uma`u eruption has enlivened volcanologists with the rare opportunity to observe eruptive processes at Kilauea’s summit, it has also caused significant environmental impact on the Island of Hawai`i. Since the beginning of 2008, the combined SO2 emissions from the east rift zone (ERZ) and summit of Kilauea have increased by ~40% as compared to the 2003-2007 long-term average. However, emissions from Kilauea’s summit have increased ~6-fold, averaging 850 t/d during January 2008-August 2009. Although average emissions from the ERZ during this period have been 1-2 times that of the summit, the relative impact of summit emissions is disproportionately large due to the location of the vent and the plume dispersal pattern to downwind communities. Ambient air quality data show that federal standards have been exceeded frequently in various communities on the south half of the island. Between April 2008 and August 2009, primary health standards for SO2 and PM2.5 were exceeded on 41 and 19 occasions respectively in Pahala, located ~30 km downwind of the Kilauea summit under prevailing trade wind conditions. Pahala, which exceeded the SO2 annual standard for 2008, had not exceeded standards prior to the opening of the Halema`uma`u vent in March 2008. In July 2008, the U.S. Secretary of Agriculture designated Hawai`i County a primary natural disaster area due to agricultural losses from volcanic emissions. Many growers of exotic flower crops in the Ka`u district suffered irrecoverable losses. Coffee and macadamia nut farmers also reported damage to their fields. While some livestock farmers reported eye irritation in cattle, more significant damage was observed in the accelerated deterioration of galvanized fencing, gates, pipelines and other infrastructure. The increase in volcanic pollution has spurred health concerns. A rise in respiratory emergencies for visitors to Kilauea caldera in early 2008 led Hawai`i Volcanoes National Park to close areas

  3. Learning Astronomy by Playing in a Park. (Spanish Title: Aprender AstronoMía Jugando en Una Plaza.) Aprender Astronomia Brincando em Uma Praça

    NASA Astrophysics Data System (ADS)

    Camino, Néstor

    2012-12-01

    trabalho alguns jogos de praça, considerados como módulos didáticos para imaginar processos astronômicos, a partir da concepção de que a aprendizagem em Astronomia deve-se desenvolver fortalecendo a relação do próprio corpo com o espaço tridimensional e com o tempo, tal como se vive ao observar o céu, construindo um "diálogo" entre o mundo real e as aprendizagens a construir. Os jogos apresentados (carrosséis e tobogãs) foram desenhados para trabalhar sobre a translação da Terra em torno do Sol, as fases da Lua e a gravidade, e sobre o que um observador percebe dos mesmos. Dá-se a descrição de cada jogo, discutem-se seus fundamentos físicos e astronômicos, e desenvolve-se uma crítica didática dos mesmos. Finalmente, comenta-se o papel que deveriam ter os docentes no apoio aos aprendizes no processo de interação com os jogos apresentados.

  4. Multiwavelength optical observations of chromospherically active binary systems. V. FF UMa (2RE J0933+624): a system with orbital period variation

    NASA Astrophysics Data System (ADS)

    Gálvez, M. C.; Montes, D.; Fernández-Figueroa, M. J.; de Castro, E.; Cornide, M.

    2007-09-01

    Context: This is the fifth paper in a series aimed at studying the chromospheres of active binary systems using several optical spectroscopic indicators to obtain or improve orbital solution and fundamental stellar parameters. Aims: We present here the study of FF UMa (2RE J0933+624), a recently discovered, X-ray/EUV selected, active binary with strong Hα emission. The objectives of this work are, to find orbital solutions and define stellar parameters from precise radial velocities and carry out an extensive study of the optical indicators of chromospheric activity. Methods: We obtained high resolution echelle spectroscopic observations during five observing runs from 1998 to 2004. We found radial velocities by cross correlation with radial velocity standard stars to achieve the best orbital solution. We also measured rotational velocity by cross-correlation techniques and have studied the kinematic by galactic space-velocity components (U, V, W) and Eggen criteria. Finally, we have determined the chromospheric contribution in optical spectroscopic indicators, from Ca ii H & K to Ca ii IRT lines, using the spectral subtraction technique. Results: We have found that this system presents an orbital period variation, higher than previously detected in other RS CVn systems. We determined an improved orbital solution, finding a circular orbit with a period of 3.274 days. We derived the stellar parameters, confirming the subgiant nature of the primary component (MP = 1.67 M⊙ and R sin{i}_P=2.17 R⊙) and obtained rotational velocities (v sin{i}), of 33.57 ± 0.45 km s-1 and 32.38 ± 0.75 km s-1 for the primary and secondary components respectively. From our kinematic study, we can deduce its membership to the Castor moving group. Finally, the activity study has given us a better understanding of the possible mechanisms that produce the orbital period variation. Based on observations collected with the 2.2 m telescope at the Centro Astronómico Hispano Alemán (CAHA

  5. Uma análise do fenômeno “alternância de línguas” na fala de bilíngues intermodais (Libras e Português)

    PubMed Central

    de Sousa, Aline Nunes; de Quadros, Ronice Müller

    2013-01-01

    Um interessante fenômeno lingüístico presente nas interações das pessoas bilíngues é a alternância de línguas. Neste trabalho, estamos investigando a alternância entre a língua portuguesa oral e a língua de sinais brasileira – Libras, numa mesma cadeia enunciativa, com o objetivo de identificar e analisar o uso dessa alternância na fala de uma criança e de um adulto (ambos ouvintes, filhos de pais surdos), interagindo em uma situação de bilinguismo intermodal, com interlocutores surdos e ouvintes. A alternância de línguas, nesse caso, ocorre quando se para de falar em português e se alterna para sinalizar. O presente trabalho se caracteriza como um estudo inicial, com análise qualitativa de dados. Fazem parte do nosso corpus nove sessões de interações em Libras e em português oral, gravadas em vídeo, que fazem parte do Projeto Desenvolvimento Bilíngue Bimodal da UFSC. Os dados revelam que as características da alternância de línguas pelo adulto e pela criança parecem ter semelhanças e diferenças. O sujeito adulto parece ter feito um uso da alternância mais preocupado com o curso da interação. A criança, por sua vez, não parece tê-la usado com propósitos pragmáticos específicos. Quanto à extensão das alternâncias, pode-se perceber que tanto a criança quanto o adulto utilizaram enunciados maiores do que uma única palavra isolada. O papel dos interlocutores parece ter sido decisivo nas interações aqui investigadas – especialmente nas do adulto, já que a criança ainda está em processo de tomada de consciência do papel do interlocutor na interação. PMID:24379831

  6. II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies.

    PubMed

    Goudouris, Ekaterini Simões; Rego Silva, Almerinda Maria do; Ouricuri, Aluce Loureiro; Grumach, Anete Sevciovic; Condino-Neto, Antonio; Costa-Carvalho, Beatriz Tavares; Prando, Carolina Cardoso; Kokron, Cristina Maria; Vasconcelos, Dewton de Moraes; Tavares, Fabíola Scancetti; Silva Segundo, Gesmar Rodrigues; Barreto, Irma Cecília; Dorna, Mayra de Barros; Barros, Myrthes Anna; Forte, Wilma Carvalho Neves

    2017-01-01

    In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published in 2010. The document presents new knowledge about the indications and efficacy of immunoglobulin therapy in primary immunodeficiencies, relevant production-related aspects, mode of use (routes of administration, pharmacokinetics, doses and intervals), adverse events (major, prevention, treatment and reporting), patient monitoring, presentations available and how to have access to this therapeutic resource in Brazil. RESUMO Nos últimos anos, novas imunodeficiências primárias e defeitos genéticos têm sido descritos. Recentemente, produtos de imunoglobulina, com aprimoramento em sua composição e para uso por via subcutânea, tornaram-se disponíveis em nosso meio. Com o objetivo de orientar o médico no uso da imunoglobulina humana para o tratamento das imunodeficiências primárias, os membros do Grupo de Assessoria em Imunodeficiências da Associação Brasileira de Alergia e Imunologia produziram um documento que teve por base uma revisão narrativa da literatura e sua experiência profissional, atualizando o I Consenso Brasileiro publicado em 2010. Apresentam-se novos conhecimentos sobre indicações e eficácia do tratamento com imunoglobulina nas imunodeficiências primárias, aspectos relevantes sobre a produção, forma de utilização (vias de administração, farmacocinética, doses e intervalos), efeitos adversos (principais efeitos, prevenção, tratamento e notificação), monitorização do

  7. Basic Concepts of Astronomy: a Methodological Proposal. (Spanish Title: Conceptos Básicos de Astronomía: Una Propuesta Metodológica.) Conceitos Básicos de Astronomia: Uma Proposta Metodológica

    NASA Astrophysics Data System (ADS)

    Darroz, Luiz Marcelo; Heineck, Renato; Samudio Pérez, Carlos Ariel

    2011-12-01

    obtenidos en diferentes momentos, por los comentarios efectuados por los participantes durante las actividades y por los altos índices de aprobación al final de la etapa, consideramos que la propuesta atingió los objetivos establecidos y puede ser repetida con certeza de éxito. Neste relato, descreve-se o desenvolvimento de uma proposta metodológica que aborda conceitos básicos de astronomia fundamentada pedagogicamente na Aprendizagem Significativa. A proposta, que compreende quatro encontros, foi desenvolvida por professores e acadêmicos do curso de Licenciatura em Física da Universidade de Passo Fundo (UPF), através de um curso de extensão, a um grupo de dez estudantes do ensino médio de uma escola pública da cidade de Passo Fundo, RS. O trabalho centrou-se em conceitos básicos de astronomia. Os indícios da aprendizagem significativa foram obtidos por instrumentos de pesquisa e avaliação aplicados ao término de cada encontro. A avaliação da proposta foi efetuada através de um questionário final respondido pelos participantes ao término do desenvolvimento das atividades. Pelos resultados obtidos nos diferentes instrumentos, pelos comentários efetuados pelos participantes durante as atividades e pelos altos índices de aprovação alcançados no questionário final, consideramos que a proposta atingiu os objetivos estabelecidos e pode ser repetida com convicção de sucesso.

  8. A Proposed Activity for a Meaningful Learning about the Moon Phases. (Breton Title: Uma Proposta de Atividade Para a Aprendizagem Significativa sobre as Fases da Lua.) Una Actividad Propuesta Para EL Aprendizaje Significativo Acerca de Las Fases de la Luna

    NASA Astrophysics Data System (ADS)

    Martins, Bruno Andrade; Langhi, Rodolfo

    2012-12-01

    This paper presents one of the concepts of Astronomy and its consequent failure in teaching this topic in high school, even when the official documents point out the necessity of Astronomy teaching at this school level. Among the spontaneous conceptions in Astronomy that high school students carry with them, even after the end of the school, we emphasized in this research the Moon phases. The development of different strategies in relation to traditional methods, aimed to teaching-learning process on this topic was considered in this study. These strategies were devised based on the reference frame of the Meaningful Learning, as elaborated by Ausubel. The proposals presented here include the active participation of students in experimental activities and other didactic activities, for their continuous evaluation during the process. These activities finished with a Comics elaboration about the Moon phases. Therefore, the objective of this paper is to present a proposal for differentiated teaching activity about Moon phases supported by the theoretical principles of Meaningful Learning at Physics classes. Este texto foca um dos conteúdos de Astronomia e a consequente falha no ensino deste tema no ensino médio, apesar de os documentos oficiais apresentarem a necessidade de se trabalhar a Astronomia neste nível de ensino. Dentre as concepções alternativas em Astronomia que os alunos do ensino médio carregam consigo, mesmo após o término dos estudos, destacamos, nesta pesquisa, o fenômeno das fases da Lua. O desenvolvimento de estratégias diferenciadas em relação ao ensino tradicional, visando o processo de ensino-aprendizagem sobre este tema, foi contemplado neste trabalho como um dos resultados obtidos sob a luz dos referenciais da aprendizagem significativa, fundamentados em Ausubel. Segundo a proposta aqui apresentada, a participação ativa dos alunos na execução de uma atividade experimental e outras atividades didáticas, que visam sua cont

  9. Portuguese and the Computer: "uma bossa nova".

    ERIC Educational Resources Information Center

    Kelly, John R.

    This paper describes the process of preparing a computer study of Brazilian Portuguese literary texts to be used both in teaching and in the preparation of a reference text. Procedural difficulties encountered in the project point out the potential and limitations of computerized research in literary studies. Seven possible areas for computer…

  10. Anorectal abscess and fistula-in-ano: evidence-based management.

    PubMed

    Rizzo, Julie A; Naig, Anna L; Johnson, Eric K

    2010-02-01

    The management of anorectal abscess and anal fistula has changed markedly with time. Invasive methods with high resulting rates of incontinence have given way to sphincter-sparing methods that have a much lower associated morbidity. There has been an increase in reports in the medical literature describing the success rates of the varying methods of dealing with this condition. This article reviews the various methods of treatment and evidence supporting their use and explores advances that may lead to new therapies.

  11. 450 Years of Chicano History in Pictures/450 Anos del Pueblo Chicano.

    ERIC Educational Resources Information Center

    Chicano Communications Center, Albuquerque, NM.

    For use with junior and senior high school students, this book presents more than 250 drawings and pictures, with an introduction and brief texts in English and Spanish, depicting 450 years of Chicano history. The book covers: Mexico before the Spanish Conquests, Spain's colonization of the Southwest, the United States war on Mexico, events in the…

  12. Consideraciones medicas y psicologicas en ninos de 5 y 6 anos de 6 guarderias infantiles

    ERIC Educational Resources Information Center

    DeSilva, Milagros Guerra; DeViloria, Carmen Leon

    1975-01-01

    This study assessed the effect of attendance at state kindergartens of a group of 181 five- and six-year-olds from low socioeconomic backgrounds. The effects of a supplemental nutritional program as well as the children's attitudes toward attendance were considered. (MS)

  13. Boletin de Informacion Educativa, Ano 2, No. 4 (Educational Information Bulletin, Volume 2, No. 4).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  14. Analisis de las Condiciones de Salud del Nino de 0-6 anos en Honduras.

    ERIC Educational Resources Information Center

    Matamoros, Douglas Alberto

    1987-01-01

    Examines the National Pediatric Service and the research program of the Maternity-Infant-Hospital-School in Honduras. Reports that health conditions of young children (birth to six years) in Honduras are appalling and that available funds for health services are inadequate, reflecting the country's economic and social crisis. (NH)

  15. Boletin de Informacion Educativa, Ano 3, No. 5 (Educational Information Bulletin, Volume 3, No. 5)

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  16. Boletin de Informacion Educativa, Ano V, No. 9 (Educational Information Bulletin, Volume V, No. 9).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  17. Boletin de Informacion Educativa, Ano III, No. 7 (Educational Information Bulletin, Volume III, No. 7).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  18. Definitive seton management for transsphincteric fistula-in-ano: harm or charm?

    PubMed

    Rosen, D R; Kaiser, A M

    2016-05-01

    The treatment of transsphincteric anal fistula requires a balance between eradication of the disease and preservation of faecal control. A cutting seton is an old tool that is now out of vogue for many surgeons. We hypothesized that the concept remains reliable and safe with results that exceed those reported for many of the more recently described methods. A retrospective review was conducted of real-time electronic health records (single institution, single surgeon) of patients presenting during the 14 years between 2001 and 2014 with a transsphincteric anal fistula who were treated with a cutting seton. Excluded were patients with Crohn's disease, fistulae related to malignancy or a previous anastomosis and patients whose fistula was treated by another method including a loose draining seton. Data collection included demographics, duration of the disease, duration of the treatment, outcome and continence. In all, 121 patients (80 men) of mean age 40.2 ± 12.2 years (range 18-76) with a mean follow-up of 5.1 ± 3.3 (1-24) months were included in the analysis. The median duration of symptoms was 6 (1-84) months; 36% had failed other fistula surgery, 12% had a complex fistula with more than one track and 35% had some form of comorbidity. The median time to healing was 3 (1-18) months; 7.4% required further surgery, but eventually 98% had complete fistula healing. The incontinence rate decreased postoperatively to 11.6% from 19% before treatment with 17/121 with pre-existing incontinence resolved and 8/107 new cases developing. Despite its retrospective non-comparative design, the study has demonstrated that a cutting seton is a safe, well tolerated and highly successful treatment for transsphincteric anal fistula and is followed overall by improved continence. The results compare very favourably with other techniques. Colorectal Disease © 2015 The Association of Coloproctology of Great Britain and Ireland.

  19. Consideraciones medicas y psicologicas en ninos de 5 y 6 anos de 6 guarderias infantiles

    ERIC Educational Resources Information Center

    DeSilva, Milagros Guerra; DeViloria, Carmen Leon

    1975-01-01

    This study assessed the effect of attendance at state kindergartens of a group of 181 five- and six-year-olds from low socioeconomic backgrounds. The effects of a supplemental nutritional program as well as the children's attitudes toward attendance were considered. (MS)

  20. Ano-rectal lymphogranuloma venereum: 22 cases reported in a sexually transmited infections center in Paris.

    PubMed

    Halioua, B; Bohbot, J M; Monfort, L; Nassar, N; de Barbeyrac, B; Monsonego, J; Sednaoui, P

    2006-01-01

    In January 2004 the European Surveillance of Sexually Transmitted Infections Network (ESSTI) issued an international alert regarding an outbreak of Lymphogranuloma venereum (LGV) in Rotterdam in a sexual network of men who have sex with men (MSM). Further to this alert, a retrospective survey was set up by the Institut de Veille Sanitaire and the reference laboratories for N.gonorrhoeae and Chlamydia in France. Our STI clinic in Paris carried out a clinico-biological retrospective study involving 154 MSM screened for anorectal sexually transmitted infections (STIs) between January 2002 and May 2004 and a prospective study between May 2004 and August 2004. Out of 216 swabs of rectal discharge from homosexual or bisexual males, a total of 32 were positive for C. trachomatis (14.8%) (3 patients in 2002, 11 in 2003 and 18 in 2004). C. trachomatis-positive rectal strains were genotyped to detect the specific C. trachomatis serovars and revealed serovars L(2) for 22 patients (respectively 1 in 2002, 9 in 2003 and 12 in 2004). Serum antibody titers for Chlamydia trachomatis were determined among 14 subjects and revealed strongly positive in 13 cases (1/512 to 1/16384) titers of IgG. These 22 patients with clinico-biologically confirmed anorectal lymphogranuloma venereum (ARLGV) were all homosexual men. They ranged from 28 to 52 years (mean age 39.2 years). 12 of 21 (57.1%) subjects with an ARLGV diagnosis were seropositive for human immunodeficiency virus (HIV) (one not done). Although rare, anorectal lymphogranuloma venereum (ARLGV) still exists in France and should not be forgotten in the differential diagnosis of rectal problems in male homosexuals.

  1. Fistula in ano surgery has no impact on pudendal nerve terminal motor latency.

    PubMed

    Daniel, Fady; Thomas, Christian; Etienney, Isabelle; Atienza, Patrick

    2006-07-01

    Anal fistula surgery is recognized as a major risk factor for anal incontinence. This incontinence is mainly due to surgical sphincter lesions, although a neurogenic mechanism through damage to the pudendal nerve is not excluded. The objective of our study was to evaluate the influence of anal surgery on the anal terminal motor latency of the pudendal nerve (PNTML). The PNTML values were measured pre- and postoperatively, respectively, in 33 patients (28 men, 5 women) treated for anal suppuration and 34 patients (21 men, 13 women) undergoing pedicular hemorrhoidectomy using the Milligan and Morgan technique. The average age was 49.6 years in the hemorrhoid group and 45 years in the fistula group (p=0.19). There was no difference in the sex ratio between the two groups (p=0.06). In the anal fistula group, the preoperative mean PNTML was 2.42 (+/-0.46) ms on the infected side and 2.40 (+/-0.42) ms on the healthy side, with a significant difference from the control group's preoperative ipsilateral latencies: 2.73 (+/-0.60) ms (p=0.02, p=0.01). The variations in the postoperative PNTML of the fistula group, both on the healthy side (DeltaPNTML=0.06+/-0.42 ms) and on the diseased side (DeltaPNTML=0.03+/-0.40 ms), are comparable with those of the hemorrhoid group (DeltaPNTML=0.01+/-0.48 ms; p=0.63, p=0.84). The nervous conduction of the pudendal nerves does not seem to be altered by the presence of an infectious process in the ischiorectal fossa nor by the surgical procedure. However, a more refined electrophysiological study would seem to be necessary to assess the repercussions on the perineal innervation.

  2. Analisis de las Condiciones de Salud del Nino de 0-6 anos en Honduras.

    ERIC Educational Resources Information Center

    Matamoros, Douglas Alberto

    1987-01-01

    Examines the National Pediatric Service and the research program of the Maternity-Infant-Hospital-School in Honduras. Reports that health conditions of young children (birth to six years) in Honduras are appalling and that available funds for health services are inadequate, reflecting the country's economic and social crisis. (NH)

  3. Treatment of Complex Fistula-in-Ano With a Nitinol Proctology Clip.

    PubMed

    Nordholm-Carstensen, Andreas; Krarup, Peter-Martin; Hagen, Kikke

    2017-07-01

    The treatment of complex anocutaneous fistulas remains a major therapeutic challenge balancing the risk of incontinence against the chance of permanent closure. The purpose of this study was to investigate the efficacy of a nitinol proctology clip for closure of complex anocutaneous fistulas. This is a single-center cohort study with retrospective analysis of all of the treated patients. Data were obtained from patient records and MRI reports, as well as follow-up telephone calls and clinical follow-up with endoanal ultrasonography. All of the patients were treated for high transsphincteric and suprasphincteric anocutaneous fistulas at the Digestive Disease Center, Bispebjerg Hospital, between May 2013 and February 2015. All of the patients were treated with the nitinol proctology clip. Primary outcome was fistula healing after proctology clip placement, as evaluated through clinical examination, endoanal ultrasonography, and MRI. The fistula healing rate 1 year after the clip procedure was 54.3% (19 of 35 included patients). At the end of follow-up, 17 (49%) of 35 patients had persistent closure of the fistula tracks. No impairment of continence function was observed. Treatment outcome was not found to be statistically associated with any clinicopathological characteristics. The study is limited by its retrospective and nonrandomized design. Selection bias may have occurred, because treatment options other than the clip were available during the study period. The small number of patients means that there is a nonnegligible risk of type II error in the conclusion, and the follow-up may be too short to have detected all of the failures. Healing rates were comparable with those of other noninvasive, sphincter-sparing techniques for high-complex anocutaneous fistulas, with no risk of incontinence. Predictive parameters for fistula healing using this technique remain uncertain. See Video Abstract at http://links.lww.com/DCR/A347.

  4. Cinco Anos Despues: A Preliminary Critique of the Sixteen Point/Spanish Speaking Program - Five Years.

    ERIC Educational Resources Information Center

    National Council of La Raza, Washington, DC.

    In 1970, the Spanish Speaking Program was launched as the Sixteen-Point Program to increase the number of Hispanic employees in the Federal Service. It functioned as part of the government-wide Equal Employment Opportunity (EEO) Program. In 1973 the U.S. Civil Service Commission's Federal Personnel Manual required agencies to take specific actions…

  5. 450 Years of Chicano History in Pictures/450 Anos del Pueblo Chicano.

    ERIC Educational Resources Information Center

    Chicano Communications Center, Albuquerque, NM.

    For use with junior and senior high school students, this book presents more than 250 drawings and pictures, with an introduction and brief texts in English and Spanish, depicting 450 years of Chicano history. The book covers: Mexico before the Spanish Conquests, Spain's colonization of the Southwest, the United States war on Mexico, events in the…

  6. Boletin de Informacion Educativa, Ano 2, No. 3. (Educational Information Bulletin, Volume 2, No. 3).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  7. Boletin de Informacion Educativa, Ano III, No. 6 (Educational Information Bulletin, Volume III, No. 6).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  8. Reading: Birth to Age 5 = La Lectura: Desde El Nacimiento Hasta Los 5 Anos

    ERIC Educational Resources Information Center

    Learning Point Associates / North Central Regional Educational Laboratory (NCREL), 2005

    2005-01-01

    Besides a change in the expectations of parents, other shifts are occurring in society that impact the youngest children (Bowman, Donovan, & Burns, 2000): (1) More women are in the workforce than ever before, which means more children are in child care or preschool; (2) There is increasing evidence of, and conviction from educators, that preschool…

  9. Teachers' Knowledge of Second Language and Curriculum: A Narrative Experience (Conocimiento de los profesores acerca de la segunda lengua y el currículo: una experiencia narrativa)

    ERIC Educational Resources Information Center

    Mendieta Aguilar, Jenny Alexandra

    2011-01-01

    This study was carried out with a group of three teachers who work for the foreign languages department of a private university in Colombia. It was aimed at unveiling and characterizing the narrative knowledge these teachers hold about language teaching and learning processes as well as the role this knowledge plays in the constant construction…

  10. Experiencias, Sentido y Significado de la Consejeria en Justicia Social a Nivel Universitario: Estudio de Caso Cualitativo Mediante Tres Narrativas De Consejeros Profesionales en Educacion Superior

    ERIC Educational Resources Information Center

    Santiago Tosado, Virginia

    2012-01-01

    The purpose of the study was to understand and profoundly describe the nature of social justice practice, as is comes up from the experience of three professional counselors whose working settings are the academic arena. Detailed descriptions are presented concerning the meanings and sense of counseling for social justice, as the interviews…

  11. Las historias de la narrativa hispanoamericana: Criterios, metodos y ausencias. (Histories of the Latin-American Narrative: Criteria, Methods, and Absences).

    ERIC Educational Resources Information Center

    Zavalo, Lauro

    This paper explains that materials on the teaching of Latin-American literature are sparse, even though most researchers in the field will dedicate much of their time to teaching. The paper adds that, in scholarly journals, little attention is given to teaching literature, and the topic is also absent from most academic congresses. The paper then…

  12. Experiencias, Sentido y Significado de la Consejeria en Justicia Social a Nivel Universitario: Estudio de Caso Cualitativo Mediante Tres Narrativas De Consejeros Profesionales en Educacion Superior

    ERIC Educational Resources Information Center

    Santiago Tosado, Virginia

    2012-01-01

    The purpose of the study was to understand and profoundly describe the nature of social justice practice, as is comes up from the experience of three professional counselors whose working settings are the academic arena. Detailed descriptions are presented concerning the meanings and sense of counseling for social justice, as the interviews…

  13. Como ayudar a su hijo durante los primeros anos de la adolescencia: Para los padres con ninos entre las edades de 10 a 14 anos (Helping Your Child through Early Adolescence: For Parents of Children from 10 through 14).

    ERIC Educational Resources Information Center

    Paulu, Nancy

    Recognizing that parents and families can greatly influence the development of their 10- through 14-year-olds, this Spanish-language booklet is part of a national effort to provide parents with the latest research and practical information to help them support their children both at home and in school. The booklet is organized in 13 sections…

  14. Desafios que Enfrentaran las Administraciones Universitarias en los Proximos Anos (Challenges for University Administration in the Years Ahead).

    ERIC Educational Resources Information Center

    Valle, Victor M.

    Ten important issues surround the challenges that Latin American university administrations will face in the near future. Those issues are: (1) the importance of administration to higher education and the need for analyzing situations, resolving problems, making decisions, and communicating at all administrative levels; (2) the uniqueness of…

  15. El curriculo creativo para ninos de cero a tres anos (The Creative Curriculum for Infants and Toddlers).

    ERIC Educational Resources Information Center

    Dombro, Amy Laura; Colker, Laura J.; Dodge, Diane Trister

    Stemming from the core idea that infant and toddler care should be based on building relationships, this curriculum in Spanish-language version provides a foundation for staff development. Section 1, "Why a Curriculum for Infants and Toddlers?" examines key quality indicators, discusses curriculum components, describes how to use the…

  16. Soy Tu Hijo: Los Primeros Anos Marcan Para Siempre (I Am Your Child: The First Years Last Forever). [Videotape].

    ERIC Educational Resources Information Center

    Reiner Foundation, Washington, DC.

    New research in brain development reveals the vital importance of the relationship between caregiver and child in the critical first years of life. This Spanish-language video explores the role of parents in stimulating early childhood development. The 28-minute video discusses: (1) attachment and the role of touch in creating a bond between…

  17. Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker

    PubMed Central

    Ta, Chau M; Adomaviciene, Aiste; Rorsman, Nils J G; Garnett, Hannah

    2016-01-01

    Background and Purpose Calcium‐activated chloride channels (CaCCs) play varied physiological roles and constitute potential therapeutic targets for conditions such as asthma and hypertension. TMEM16A encodes a CaCC. CaCC pharmacology is restricted to compounds with relatively low potency and poorly defined selectivity. Anthracene‐9‐carboxylic acid (A9C), an inhibitor of various chloride channel types, exhibits complex effects on native CaCCs and cloned TMEM16A channels providing both activation and inhibition. The mechanisms underlying these effects are not fully defined. Experimental Approach Patch‐clamp electrophysiology in conjunction with concentration jump experiments was employed to define the mode of interaction of A9C with TMEM16A channels. Key Results In the presence of high intracellular Ca2+, A9C inhibited TMEM16A currents in a voltage‐dependent manner by entering the channel from the outside. A9C activation, revealed in the presence of submaximal intracellular Ca2+ concentrations, was also voltage‐dependent. The electric distance of A9C inhibiting and activating binding site was ~0.6 in each case. Inhibition occurred according to an open‐channel block mechanism. Activation was due to a dramatic leftward shift in the steady‐state activation curve and slowed deactivation kinetics. Extracellular A9C competed with extracellular Cl−, suggesting that A9C binds deep in the channel's pore to exert both inhibiting and activating effects. Conclusions and Implications A9C is an open TMEM16A channel blocker and gating modifier. These effects require A9C to bind to a region within the pore that is accessible from the extracellular side of the membrane. These data will aid the future drug design of compounds that selectively activate or inhibit TMEM16A channels. PMID:26562072

  18. Informacion Bibliografica: Ano 3, Num. 9, Enero-Febrero, 1972 (Bibliographic Information: Volume 3, Number 9, January-February 1972).

    ERIC Educational Resources Information Center

    Martinez Martinez, Antonio L., Ed.

    This bulletin contains several articles on various topics concerning information science. The first article is a report on the November 1971 Seminar on Documentation and Pedagogical Information in Latin America held in Panama. The second article, entitled "Informatica," provides a discussion of information science by three Soviet writers;…

  19. Multi-Informant Assessment of Anxiety regarding Ano-Genital Examinations for Suspected Child Sexual Abuse (CSA)

    ERIC Educational Resources Information Center

    Scribano, Philip V.; Hornor, Gail; Rhoda, Dale; Curran, Sherry; Stevens, Jack

    2010-01-01

    Objective: Given the commonly held belief that physical examinations for child sexual abuse (CSA) are very distressing, our primary objective was to evaluate anxiety during these assessments using the Multidimensional Anxiety Score for Children (MASC-10). A second objective was to compare self-reported anxiety to parental report using the MASC-10…

  20. Boletin de Informacion Educativa, Ano VI, No. 10/11 (Educational Information Bulletin, Volume VI, No. 10/11).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  1. El curriculo creativo para ninos de cero a tres anos (The Creative Curriculum for Infants and Toddlers).

    ERIC Educational Resources Information Center

    Dombro, Amy Laura; Colker, Laura J.; Dodge, Diane Trister

    Stemming from the core idea that infant and toddler care should be based on building relationships, this curriculum in Spanish-language version provides a foundation for staff development. Section 1, "Why a Curriculum for Infants and Toddlers?" examines key quality indicators, discusses curriculum components, describes how to use the…

  2. Incidence of ano-genital and head and neck malignancies in women with a previous diagnosis of cervical intraepithelial neoplasia.

    PubMed

    Gaudet, Marc; Hamm, Jeremy; Aquino-Parsons, Christina

    2014-09-01

    The objective of this study was to determine if women with a history of Cervical Intraepithelial Neoplasia grades 2 and 3 (CIN2 and CIN3) are at increased long-term risk for developing non-cervix HPV-related malignancies. Women diagnosed with CIN2 or CIN3 between 1980 and 2005 were identified from the British Columbia (BC) Cancer Agency Cervical Cancer Screening Program's database. These patients' records were then cross-referenced with the BC Cancer Registry for diagnosis of vulvar, vaginal, anal or head and neck (HN) cancers during the period subsequent to their diagnosis of CIN. Standardized incidence ratios (SIR) were generated according to expected rates of each cancer. 54,320 women with a diagnosis of CIN2 or CIN3 were identified between 1985 and 2005. The crude incidence rate for non-cervix HPV-related cancers was 35.4 per 100,000 person-years (8.6 for vagina, 17.6 for vulva, 3.7 for anal canal and 5.5 for HN). The SIR was 1.9 (95% CI 1.3-2.7) for all non-cervix cancers, 6.7 (95% CI: 3.0-12.8) for vagina, 2.9 (95% CI: 1.7-4.6) for vulva, 1.8 (95% CI: 0.4-4.7) for anal canal, and 0.6 (95% CI: 0.2-1.4) for HN. There were statistically significant increases in anal cancers for years 5-9 and in HN cancers for years 0.5-5. BC women with a history of CIN2 or CIN3 are at relatively high risk of developing non-cervical HPV-related malignancies. The findings of this study suggest that interventions such as vaccination against high-risk HPV or long-term screening for these other cancers should be evaluated. Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.

  3. America o Aztlan? Los Chicanos En El Ano 2001 (America or Aztalan? Chicanos in the year 2001).

    ERIC Educational Resources Information Center

    de Ortego y Gasca, Felipe

    The future, more than any time in the past, will require of Chicanos a collective effort if they are to preserve their legacy of language and culture for their children. To prepare for the year 2001, Chicanos should be aware of future concerns and take action to address them. Chicanos could best realize national visibility and importance by…

  4. Multi-Informant Assessment of Anxiety regarding Ano-Genital Examinations for Suspected Child Sexual Abuse (CSA)

    ERIC Educational Resources Information Center

    Scribano, Philip V.; Hornor, Gail; Rhoda, Dale; Curran, Sherry; Stevens, Jack

    2010-01-01

    Objective: Given the commonly held belief that physical examinations for child sexual abuse (CSA) are very distressing, our primary objective was to evaluate anxiety during these assessments using the Multidimensional Anxiety Score for Children (MASC-10). A second objective was to compare self-reported anxiety to parental report using the MASC-10…

  5. Boletin Estadistico de la Educacion: Ano VI, No. 1 (Statistical Bulletin on Education: Volume VI, No. 1).

    ERIC Educational Resources Information Center

    Ministerio de Educacion, Guatemala City (Guatemala). Oficina de Planeamiento Integral de la Educacion.

    This booklet presents statistics concerning primary education in Guatemala. The first section covers enrollment, considering such factors as type of school and location. Other sections provide statistics on teachers, their locations, the number of schools, enrollment in terms of students repeating grades or leaving school, students advancing out…

  6. The Universe in a Box: Introduction to the Study of Astronomy in the Initial Formation of Physics Teachers. (Spanish Title: El Universo Representado en Una Caja: Introducción al Estudio de la Astronomía en la Formación Inicial de Profesores de Física.) O Universo Representado em Uma Caixa: Introdução ao Estudo da Astronomia NA Formação Inicial de Professores de Física

    NASA Astrophysics Data System (ADS)

    Longhini, Marcos Daniel

    2009-07-01

    This is a report of an activity of introduction to the study of Astronomy developed with a group of future Physics teachers at a Brazilian public university. Such activity had the goal of giving privileged emphasis to notions of spatiality, alternative conceptions of the participants and the process of interaction among peers, and consisted of the representation, in a three dimensional space, of the models of the universe that the participants had. The results, which were categorized as miscellaneous, geocentric, heliocentric and acentric models of the universe, were qualitatively analyzed. Analyses of the activity in the perspective of the participants are indicated and additional considerations are made regarding its use as a resource for teaching Astronomy and for teacher training. Este es el informe de una actividad para presentar un estudio introductorio de la Astronomía, desarrollado con una clase de futuros profesores de física en una universidad pública brasileña. Esta actividad tuvo como objetivo centrar las nociones de espacialidad, las concepciones alternativas de los participantes y el proceso de interacción entre pares, y consistió en la representación en un espacio tridimensional, de los modelos del universo que los participantes habían. Los resultados, que se clasificaron en universo miscelania, geocéntrico, heliocéntrico y acentrico, se analizaron cualitativamente. Son identificadas análisis de la actividad por los participantes, e hizo observaciones sobre su uso como recurso para la enseñanza de la astronomía y la formación de docentes. Trata-se do relato de uma atividade de introdução ao estudo da Astronomia, desenvolvida com uma turma de futuros professores de Física, em uma universidade pública brasileira. Tal atividade teve como meta privilegiar noções de espacialidade, as concepções alternativas dos participantes e o processo de interação entre pares e constou da representação, em um espaço tridimensional, dos

  7. STT Doubles with Large DM - Part II: Leo and UMa

    NASA Astrophysics Data System (ADS)

    Ahad, Abdul

    2016-02-01

    This paper documents the discovery of a new double star in Cygnus, currently not listed in the WDS catalog. On observed photometric and proper motion characteristics, calibration of distances, and other assumptions, it is concluded that the components comprise a wide gravitationally-bound visual binary system.

  8. Molecular Hydrogen in the Quiescent Disk of SW UMa

    NASA Technical Reports Server (NTRS)

    Raymond, John C.

    2004-01-01

    The FUSE observation has been reduced and a paper has been submitted to ApJ. The analysis has been slow because of the very noisy quality of the data, but we have derived line profile information for O VI and limits to the continuum brightness which place an interesting limit on the white dwarf temperature. The primary results are that a narrow O VI emission component seems to arise from the accretion flow onto the white dwarf itself, in agreement with cooling flow models for the X-ray spectra of low accretion rate dwarf novae. The broad component of the O VI lines is weaker than the observed C IV emission, suggesting that the UV line emission from the disk comes from photoionized plasma. A secondary result is that there is no H-2 fluorescent emission. The upper limits indicate that if molecular gas is present in the disk, it is shielded from Ly alpha photons by a layer of atomic hydrogen on the disk surface. We also derive an upper limit to the continuum level is below that observed by IUE. The limits are compatible with the lower end of the WD temperature range derived from IUE measurements, and they appear to agree with unpublished analysis of HST spectra. The grant has provided partial support for a data aide (Matt Povich) and a postdoc (Alex Lobel). It purchased a computer for M. Menou.

  9. The Illness Experience: Palliative Care Given the impossibility of Healing.

    PubMed

    Dantas, Margarida Maria Florêncio; Amazonas, Maria Cristina Lopes de Almeida

    2016-06-01

    This paper presents a reflection about being terminally ill and the various ways that the subject has at its disposal to deal with this event. The objective is to understand the experience of palliation for patients undergoing no therapeutic possibilities of cure. The methodology of this study has the instruments to semi-structured interview, the participant observation and the field diary, and the Descriptive Analysis of Foucault's inspiration how the narratives of the subjects were perceived. The Results of paper there was the possibility of looking at the experience of illness through the eyes of a subject position assumed by the very sick. As conclusion we have than when choosing palliative care, the terminally ill opts for a way to feel more comfortable and resists the impositions of the medical model of prolonging life. O presente trabalho traz uma reflexão a respeito do ser um doente terminal e das várias maneiras que o sujeito tem a seu dispor para lidar com esse acontecimento. Nosso objetivo foi compreender a experiência da paliação por sujeitos doentes sem possibilidades terapêuticas de cura. A metodologia deste estudo teve como instrumentos a Entrevista Narrativa, a Observação Participante e o Diário de Campo, sendo a Análise Descritiva de inspiração foucaultiana o modo como as narrativas dos sujeitos foram percebidas. O resultado do estudo mostrou a possibilidade de olhar a experiência do adoecer através da ótica de uma posição de sujeito assumida pelo próprio enfermo. E concluímos que ao escolher os cuidados paliativos, o doente terminal opta por um modo de se sentir mais confortável e resiste às imposições do modelo médico de prolongamento da vida.

  10. Periprosthetic humeral fractures after reverse shoulder arthroplasty. Case report.

    PubMed

    Wajnsztejn, Andre; Foni, Noel Oizerovici; Oizerovici, Dan; Pires, Robinson Esteves Santos; Ejnisman, Benno

    2017-09-21

    Periprosthetic fractures is a severe complication after joint replacement. The rapidly increase of reverse shoulder arthroplasty surgeries, periprosthetic humeral fractures, which are described as rare, may increase in the near future. We report the case of displaced humeral fracture bellow the stem of reverse shoulder prosthesis. The patient was an 85-year-old woman who had a total shoulder replacement 6 years previously. The surgical solution consisted of plate osteossynthesis and cerclage. This report describes an unprecedented case in Brazilian literature; and gives an overview of the existing literature including this injury classification. RESUMO As fraturas periprotéticas do ombro representam uma grave complicação após a substituição da articulação. Devido ao rápido aumento do número de cirurgias de artroplastia reversa no ombro, as fraturas periprótese do úmero, descritas como raras, podem aumentar no futuro próximo. Descrevemos um caso de fratura desviada do úmero abaixo do componente umeral de uma artroplastia reversa. A paciente era uma mulher de 85 anos de idade, que tinha uma artroplastia reversa do ombro há 6 anos. O tratamento cirúrgico consistiu em osteossíntese com placa, parafusos e cerclagem. Os objetivos do presente trabalho foram reportar um caso inédito na literatura brasileira, e revisar a literatura existente e as classificações da lesão.

  11. A Diagnostic Assessment for the Teaching of Astronomy. (Spanish Title: Una Evaluación Diagnóstica Para la Enseñanza de la Astronomia.) Uma Avaliação Diagnóstica Para o Ensino da Astronomia

    NASA Astrophysics Data System (ADS)

    Pacifico Ribeiro de Assis Silveira, Felipa; Soares Gomes de Sousa, Célia Maria; Moreira, Antonio

    2011-07-01

    interpretación, lo que nos permite comprender los significados asignados por el estudiante a estos conceptos. Se desprende de la evaluación diagnóstica que la mayoría de los encuestados ha tenido dificultades para exponer los conceptos científicos sobre el Universo y la Tierra, para iniciar el 6 º grado. Sin embargo, se identificaron ideas relevantes y las representaciones que contribuyeron a la re-significación de los conceptos científicos propuestos para la enseñanza del tema en esta serie. Los resultados de la evaluación diagnóstica han servido como referencia para la organización del Programa, facilitando el proceso de aprendizaje, haciendo coincidir la secuencia didáctica a las características de los estudiantes y el contexto del aula. Se espera que el instrumento presentado en este documento también pueda ser utilizado por otros investigadores en investigaciones relacionadas con el tema. Este artigo tem como objetivo apresentar os resultados de uma avaliação diagnóstica, utilizada como instrumento para a coleta de dados sobre o conhecimento prévio de conceitos científicos, necessários à compreensão do tema Terra e Universo, de um grupo composto por 47 estudantes, da 6ª série do Ensino Fundamental. A ação pedagógica de diagnosticar os conhecimentos prévios, do estudante, antes de ensiná-los, tem fundamento na teoria da Aprendizagem Significativa, proposta por David Ausubel. Essa avaliação diagnóstica foi composta por 25 questões, cujas respostas foram analisadas e categorizadas visando sua interpretação, o que permitiu compreender os significados atribuídos pelo estudante a esses conceitos. Conclui-se, a partir da avaliação diagnóstica, que a maioria dos estudantes pesquisados apresentou dificuldades em expor conceitos científicos sobre o tema Terra e Universo ao iniciar a 6ª série. Entretanto, foram identificadas ideias e representações relevantes que contribuíram para a (re)significação dos conceitos científicos propostos

  12. Inclusion of Astronomy Themes in an Inovative Approach of Informal Physics Teaching for High School Students. (Spanish Title: Inclusión de Temas Astronómicos en Uma Abordaje Innovadora de la Enseñanza Informal de Física Para Estudiantes de Secumdaria.) Inclusão de Temas Astronômicos Numa Abordagem Inovadora do Ensino Informal de Física Para Estudantes do Ensino Médio

    NASA Astrophysics Data System (ADS)

    Tiara Mota, Aline; de Morais Bonomini, Iracema Ariel; Meloni Martins Rosado, Ricardo

    2009-12-01

    The current work reports on an experience on Astronomy education at the Federal University of Itajubá through an extra-curricular course offered for High School students. This initiative was motivated by the low attention paid to the Astronomy subjects at this stage of the Brazilian Formal Education, in spite that the National Curricular Parameters (PCN and PCN+, in Brazil) point out the importance of their inclusion Este artículo relata una experiencia en la enseñanza de la astronomía efectuada en la Universidad Federal de Itajubá en la forma de un curso de extensión orientado para los estudiantes del colegio secundario. Esta iniciativa surgió de constatar la poca atención dada a la Astronomía en esta etapa de la Educación formal brasileña, a pesar que los Parámetros Curriculares Nacionales (PCN y PCN+, en Brasil) destacan la importancia de su inclusión. Este artigo relata uma experiência em ensino de Astronomia realizada na Universidade Federal de Itajubá na forma de um curso de extensão voltado para alunos do Ensino Médio. Esta iniciativa surgiu da pouca atenção que se dá à Astronomia nesta etapa da Educação embora os Parâmetros Curriculares Nacionais (PCN e PCN+) apontem a importância de sua inclusão.

  13. Peculiaridades observadas no espectro da estrela magnética HD 190073 - candidata a estrela do tipo Ae de Herbig

    NASA Astrophysics Data System (ADS)

    Franco, G. A. P.; Pogodin, M. A.; Lopes, D. F.

    2003-08-01

    Apresentaremos os resultados de uma investigação espectroscópica cooperativa da estrela magnética HD 190073. As observações foram conduzidas no Observatório do Pico dos Dias (LNA/MCT), European Southern Observatory (ESO, Chile), e Crimean Astrophysical Observatory (CrAO, Ucrânia), entre 1998 e 2002. Discutiremos em detalhe um dos padrões mais marcantes do espectro desse objeto - as multicomponentes em absorção das linhas Ca ii K e H. De acordo com nossos resultados, a estrutura complexa desse perfil permaneceu constante durante várias decadas (dos anos 30 até os anos 80) após o que apresentou mudanças marcantes nos anos 90. Essa variabilidade apresenta óbvia contradição com a interpretação tradicional desse fenômeno como o resultado de espalhamento ressonante atuando seletivamente sobre o vento estelar em distâncias diferentes. Propomos uma explicação alternativa com base em uma topologia especí fica do campo magnético estelar. Essa hipótese permite, também, explicar uma série de outras peculiaridades observadas no envoltório de HD 190073, tais como: (a) a baixa velocidade de rotação pode ser o resultado da interação entre a magnetosfera estelar e um disco equatorial hipotético; (b) o gás circumstelar acumulado em loops magnéticos em latitudes intermediárias pode estimular a formação de regiões gasosas densas a distâncias intermediárias da estrela, onde linhas em emissão com perfil simples são formadas.

  14. Stigma and Attitudes towards Psychiatric Patients in Portuguese Medical Students.

    PubMed

    Telles-Correia, Diogo; Gama Marques, João; Gramaça, João; Sampaio, Daniel

    2015-01-01

    Introdução: Este estudo pretende avaliar o impacto da educação psiquiátrica nas atitudes em alunos de medicina face aos doentes mentais. Material e Métodos: Foi conduzido um inquérito em corte transversal na maior faculdade de medicina portuguesa. Os alunos preencheram um questionário que incluía informação sociodemográfica, antecedentes pessoais e familiares de doença psiquiátrica, bem como a Community Attitudes towards the Mentally Ill scale. Resultados: Em 2 178 estudantes, 398 responderam ao inquérito, representando 18,2% daquela faculdade de medicina. Houve uma significativa melhoria em todas as dimensões avaliadas pela Community Attitudes towards the Mentally Ill scale, ao longo dos anos do curso de medicina. Os valores mais elevados verificaram-se na subescala Restritividade (38,01), e os valores mais baixos na sub-escala Autoritarismo (36,13). A melhor diferença verificou-se para a sub-escala Autoritarismo (5º ano - 1º ano = 2,03), e a pior diferença verificou-se para a sub-escala Benevolência (5º ano - 1º ano = 0,39). Os melhores resultados foram encontrados no final do 3º ano. Discussão: Os resultados poderão dever-se ao módulo de luta contra o estigma, incluído na disciplina de 'Introdução à Saúde Mental'. Esse efeito positivo ter-se-á perdido no 4º e 5º anos, com uma degradação das atitudes.Conclusão: Este estudo salienta a import'ncia dos módulos de luta contra o estigma na melhoria das atitudes dos estudantes de medicina perante a saúde mental. Este tipo de acções pedagógicas preventivas com intuito anti-estigma, devem ser na melhor preparação possível de gerações Médicas futuras.

  15. Cost-effectiveness of screening for anal cancer using regular digital ano-rectal examinations in men who have sex with men living with HIV

    PubMed Central

    Ong, Jason J; Fairley, Christopher K; Carroll, Susan; Walker, Sandra; Chen, Marcus; Read, Tim; Grulich, Andrew; Bradshaw, Catriona; Kaldor, John; Clarke, Philip

    2016-01-01

    Introduction Anal cancer in men who have sex with men (MSM) living with HIV is an important issue but there are no consistent guidelines for how to screen for this cancer. In settings where screening with anal cytology is unavailable, regular anal examinations have been proposed in some guidelines but their cost-effectiveness is unknown. Methods Our objective was to estimate the cost-effectiveness of regular anal examinations to screen for anal cancer in HIV-positive MSM living in Australia using a probabilistic Markov model. Data sources were based on the medical literature and a clinical trial of HIV-positive MSM receiving an annual anal examination in Australia. The main outcome measures for calculating effectiveness were undiscounted and discounted (at 3%) lifetime costs, life years gained, quality-adjusted life years (QALY) gained and incremental cost-effectiveness ratio (ICER). Results Base-case analysis estimated the average cost of screening for and management of anal cancer ranged from $195 for no screening to $1,915 for lifetime annual screening of men aged ≥ 50. Screening of men aged ≥ 50 generated ICERs of $29,760 per QALY gained (for screening every four years), $32,222 (every three years) and $45,484 (every two years). Uncertainty for ICERs was mostly influenced by the cost (financially and decrease in quality of life) from a false-positive result, progression rate of anal cancer, specificity of the anal examination, the probability of detection outside a screening program and the discount rate. Conclusions Screening for anal cancer by incorporating regular anal examinations into routine HIV care for MSM aged ≥ 50 is most likely to be cost-effective by conventional standards. Given that anal pap smears are not widely available yet in many clinical settings, regular anal exams for MSM living with HIV to detect anal cancer earlier should be implemented. PMID:26942721

  16. "Cien Anos de Soledad" y el concepto de la "Caida Afortunada" ("One Hundred Years of Solitude" and the Concept of the "Fortunate Fall")

    ERIC Educational Resources Information Center

    Dario Carrillo, German; Stults, Barry

    1972-01-01

    Shows the influence of R.W.B. Lewis' work about the fall of Adam on the Marquez novel. Marquez' view coincides with Lewis' that Adam's fall should be considered not as a lapse from divine favor, but as an actual rise to the normal human level. (DS)

  17. A Parent's Guide to Infant/Toddler Programs = Guia para los padres sobre los programas de cuidado infantil de 0-3 anos.

    ERIC Educational Resources Information Center

    Dodge, Diane Trister; Dombro, Amy Laura; Colker, Laura J.

    Information on how warm and responsive care can help shape infants' and toddlers' development and their ability to learn can be reassuring for concerned parents. This guide, in English and Spanish versions, presents quality child care as a partnership between the child caregiver and the parents with the primary goal of benefiting the child. The…

  18. Ano-genital human papillomavirus type 97 infection is detected in Canadian men but not women at risk or infected with the human immunodeficiency virus.

    PubMed

    Landry, Marie-Eve; Salit, Irving E; Rodrigues-Coutlée, Catherine; Money, Deborah; Rebbapragada, Anu; Tinmouth, Jill; Hankins, Catherine; Gorska-Flipot, Isabelle; Archambault, Jacques; Franco, Eduardo L; Coutlée, François

    2012-10-23

    Human papillomavirus type 97 (HPV97) DNA was detected in nearly 5% of anal samples collected from HIV-seropositive men living in Montreal, Canada. The rate of detection of HPV97 in the genital tract of Canadian women is unknown. Whether HPV97 is a local epidemic in HIV-seropositive men living in Montreal is also unknown. The prevalence of human papillomavirus type 97 (HPV97) was assessed in cervicovaginal cells from women living in Canada and in anal samples from HIV-seropositive men living in Toronto. Cervicovaginal lavages collected from 904 women (678 HIV-seropositive, 226 HIV-seronegative) women living in Canada and anal cells collected from 123 HIV-seropositive men living in Toronto were tested for the presence of HPV97 with PCR. HPV97-positive samples were further tested by PCR-sequencing for molecular variant analysis to assess if all HPV97-positive men were infected with the same strain. All cervicovaginal samples were negative for HPV97. HPV97 was detected in anal samples from 6 HIV-seropositive men (4.9%, 95% confidence interval 2.0-10.5%), of whom five had high-grade and one had low-grade anal intraepithelial neoplasia, in addition to 2 to 8 HPV genital genotypes per sample. Four HPV97 variants were defined by four variation sites in the viral control region. These findings indicate that HPV97 infects in the anal canal of HIV-seropositive men but is not detected in the genital tract of women.

  19. Ano-genital human papillomavirus type 97 infection is detected in Canadian men but not women at risk or infected with the human immunodeficiency virus

    PubMed Central

    2012-01-01

    Background Human papillomavirus type 97 (HPV97) DNA was detected in nearly 5% of anal samples collected from HIV-seropositive men living in Montreal, Canada. The rate of detection of HPV97 in the genital tract of Canadian women is unknown. Whether HPV97 is a local epidemic in HIV-seropositive men living in Montreal is also unknown. The prevalence of human papillomavirus type 97 (HPV97) was assessed in cervicovaginal cells from women living in Canada and in anal samples from HIV-seropositive men living in Toronto. Findings Cervicovaginal lavages collected from 904 women (678 HIV-seropositive, 226 HIV-seronegative) women living in Canada and anal cells collected from 123 HIV-seropositive men living in Toronto were tested for the presence of HPV97 with PCR. HPV97-positive samples were further tested by PCR-sequencing for molecular variant analysis to assess if all HPV97-positive men were infected with the same strain. All cervicovaginal samples were negative for HPV97. HPV97 was detected in anal samples from 6 HIV-seropositive men (4.9%, 95% confidence interval 2.0-10.5%), of whom five had high-grade and one had low-grade anal intraepithelial neoplasia, in addition to 2 to 8 HPV genital genotypes per sample. Four HPV97 variants were defined by four variation sites in the viral control region. Conclusion These findings indicate that HPV97 infects in the anal canal of HIV-seropositive men but is not detected in the genital tract of women. PMID:23092191

  20. La Educacion en America Latina y El Caribe Durante Los Proximos 25 Anos. (Education in Latin America and the Caribbean during the Next 25 Years.)

    ERIC Educational Resources Information Center

    Roggi, Luis Osvaldo, Ed.

    1987-01-01

    The nine papers appearing in this document review both limitations and progress in education in Latin America, study the future of education in Latin America and the Caribbean, and make recommendations to the Regional Program for Educational Development (PREDE). There is, in addition, a lengthy transcription of a discussion, among eight of the…

  1. Indice Bibliografico Ciencias de la Educacion. Ano 1988. Volume II No. 1. (Bibliographic Index of the Education Sciences. 1988. Volume II No.1).

    ERIC Educational Resources Information Center

    Centro de Investigacion, Madrid (Spain). Servicio de Documentacion.

    Published quarterly, this annotated bibliography indexes articles from scholarly Spanish journals, as well as significant foreign journals, considered important in the field of education. References are organized alphabetically according to subject and within each subject by number, author, and content. A users' information description is provided…

  2. Me escuchas? Como conversar con ninos de cuatro a doce anos (Are You Listening to Me? Communicating with Children from Four to Twelve Years Old).

    ERIC Educational Resources Information Center

    Delfos, Martine F.

    Although talking to children is a daily activity for almost everyone at some stage in one's life and an essential activity for professionals who work with children, there is little research on activity. This Spanish-language book describes communication with children between the ages of 4 and 12 years, focusing on open question-and-answer sessions…

  3. Sugerencias para la Evolucion del Desarrollo: 0-5 Anos (Stages for the Development of Discovery [Learning in] 0-5 Year-Olds).

    ERIC Educational Resources Information Center

    Organization of American States, Washington, DC.

    Some points that may serve as a foundation of experience and reference in the stimulation of mentally retarded children during the years of one through five are presented. Points of development are given for the following breakdowns of time: three months, six months, nine months, 12 months, 18 months, two years, three years, four years, and five…

  4. La Educacion Especial para Ninos con Impedimentos Desde Recien Nacidos Hasta Cinco Anos de Edad = Special Education for Handicapped Children Birth to Five.

    ERIC Educational Resources Information Center

    New York State Education Dept. Albany. Office for the Education of Children with Handicapping Conditions.

    The manual, in Spanish, describes programs and resources available for preschool handicapped children and their families in conjunction with the New York State Education Department. Section 1 on assistance in securing services, reviews the service provided by Early Childhood Direction Centers, and outlines the role of local Committees on the…

  5. La investigacion sobre la calidad de los programas para ninos de hasta dos anos de edad (Research on Quality in Infant-Toddler Programs). ERIC Digest.

    ERIC Educational Resources Information Center

    Honig, Alice Sterling

    Concern about the quality of infant-toddler care programs has grown recently in response to two factors. The first is the need of employed parents for such care, and the second is research emphasizing the importance of brain development in the early years. This Spanish-language Digest introduces some of the many issues related to the quality of…

  6. La Educacion Especial para Ninos con Impedimentos Desde Recien Nacidos Hasta Cinco Anos de Edad = Special Education for Handicapped Children Birth to Five.

    ERIC Educational Resources Information Center

    New York State Education Dept. Albany. Office for the Education of Children with Handicapping Conditions.

    The manual, in Spanish, describes programs and resources available for preschool handicapped children and their families in conjunction with the New York State Education Department. Section 1 on assistance in securing services, reviews the service provided by Early Childhood Direction Centers, and outlines the role of local Committees on the…

  7. La Educacion en America Latina y El Caribe Durante Los Proximos 25 Anos. (Education in Latin America and the Caribbean during the Next 25 Years.)

    ERIC Educational Resources Information Center

    Roggi, Luis Osvaldo, Ed.

    1987-01-01

    The nine papers appearing in this document review both limitations and progress in education in Latin America, study the future of education in Latin America and the Caribbean, and make recommendations to the Regional Program for Educational Development (PREDE). There is, in addition, a lengthy transcription of a discussion, among eight of the…

  8. Ligation of the intersphincteric fistula tract plus a bioprosthetic anal fistula plug (LIFT-Plug): a new technique for fistula-in-ano.

    PubMed

    Han, J G; Yi, B Q; Wang, Z J; Zheng, Y; Cui, J J; Yu, X Q; Zhao, B C; Yang, X Q

    2013-05-01

    Ligation of the intersphincteric fistula tract and reinforcement with a bioprosthetic graft are two recently reported procedures that have shown promise in the treatment of anal fistula. This study was undertaken to validate combining ligation of the intersphincteric fistula tract plus bioprosthetic anal fistula plug and report our preliminary results and experience. Twenty-one patients with transsphincteric anal fistula were treated with ligation of the intersphincteric fistula tract plus concurrent bioprosthetic plug of the anal fistula. We evaluated healing time, fistula closure rate and postoperative anal function according to the Wexner continence score. No mortality or major complications were observed. Median operative time was 20 (range 15-40) min. After a median follow-up of 14 (range 12-15) months, the overall success rate was 95% (20/21), with a median healing time of 2 (range 2-3) weeks for external anal fistula opening and 4 (range 3-7) weeks for intersphincteric groove incision. Only 1 (5%) patient reported rare incontinence for gas postoperatively (Wexner score 1). Ligation of the intersphincteric fistula tract plus a bioprosthetic anal fistula plug is an easy, safe, effective and useful alternative in the management of anal fistula. Further randomized controlled studies are necessary to better evaluate long-term results. © 2012 The Authors. Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland.

  9. Indice Bibliografico Ciencias de la Educacion. Ano 1988. Volume II No. 1. (Bibliographic Index of the Education Sciences. 1988. Volume II No.1).

    ERIC Educational Resources Information Center

    Centro de Investigacion, Madrid (Spain). Servicio de Documentacion.

    Published quarterly, this annotated bibliography indexes articles from scholarly Spanish journals, as well as significant foreign journals, considered important in the field of education. References are organized alphabetically according to subject and within each subject by number, author, and content. A users' information description is provided…

  10. 1990: Ano Internacional de la alfabetizacion: Acciones sugeridas para America Latina y el Caribe = 1990 International Literacy Year: Suggested Actions for Latin America and the Caribbean.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Michoacan (Mexico). Regional Office for Educ. in Latin America & Caribbean.

    This booklet discusses the needs for literacy education in Latin America and the Caribbean during International Literacy Year. Particular focus is on the objectives of International Literacy Year and suggested actions are provided in the four following areas: (1) operative strategies for the realization of the International Literacy Year,…

  11. Co-operativity among defect sites in AnO2+ and An4O9 (An = U, Np or Pu)

    SciTech Connect

    Andersson, Anders David; Lezama Pacheco, Juan; Uberuaga, Blas P; Conradson, Steven D

    2008-01-01

    Actinide dioxides derived from the AnO{sub 2} fluorite lattice are of high technological relevance due to their application in nuclear reactor fuels. Oxidation of AnO{sub 2} compounds emerges as a central theme in fuel fabrication, reactor operation, long-term storage forms for both spent fuels and surplus weapons materials, and environmental actinide migration. In this paper, we use density functional theory calculations to study the oxidation of uranium, neptunium and plutonium dioxides, AnO{sub 2} (An = U, Np or Pu), in O{sub 2} and O{sub 2}/H{sub 2}O environments. We pay particular attention to the formation of oxygen clusters (co-operativity) in AnO{sub 2+x} and how this phenomenon govern oxidation thermodynamics and the development of ordered An{sub 4}O{sub 9} compounds. The so-called split di-interstitial, which is composed of two nearest neighbor octahedral oxygen interstitials that are distorted in such a way that they dislocate one regular fluorite lattice oxygen ion to form a cluster of triangular geometry, is predicted to be the fundamental building block of the most stable cluster configurations. We also identify how the formation of oxygen defect clusters and the degree of oxidation in AnO{sub 2+x} are both governed by the characer of the An-5f to excess O-2p charger transfer, i.e. the charge transfer to the O-2p orbitals of the interstitial-like (+x) ions, and the ability of the excess O-2p orbitals to hybridize with regular fluorite lattice ions.

  12. 1,6-anhydro-2, 3-di-O-benzyl-5C-[(R)-ethoxycarbonyl(hydroxy)methyl]-beta-L-altrofur ano se.

    PubMed

    Taillefumier, C; Charron, C; Chapleur, Y; Aubry, A

    2000-09-01

    The crystal structure of the title compound, C(24)H(28)O(8), has been determined. The conformation of the furanose ring can be described as 58% ideal envelope (O)E conformer and 42% ideal twisted (O)T(1) conformer. The 1,3-dioxane ring adopts a chair conformation with the anhydro-O atom pointing upwards. Both phenyl rings are quasi-perpendicular to the mean plane of the furanose ring. The hydrogen bonding is intermolecular and consists of infinite chains parallel to the a axis.

  13. Molecular Confirmation of Anopheles (Anopheles) lesteri from the Republic of South Korea and its Genetic Identity with An. (Ano.) anthropophagus from China (Diptera: Culicidae)

    DTIC Science & Technology

    2003-12-08

    genus Anopheles (Beebe et al. 1999; Fritz 1998; Marinucci et al. 1999; Paskewitz et al. 1993; Wilkerson et al. In press). Morphological...Control Association, 16, 189- 198. Marinucci , M., Romi, R., Mancini, P., Di, L.M. & Severini, C. (1999) Phylogenetic relationships of seven

  14. 1990: Ano Internacional de la alfabetizacion: Acciones sugeridas para America Latina y el Caribe = 1990 International Literacy Year: Suggested Actions for Latin America and the Caribbean.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Michoacan (Mexico). Regional Office for Educ. in Latin America & Caribbean.

    This booklet discusses the needs for literacy education in Latin America and the Caribbean during International Literacy Year. Particular focus is on the objectives of International Literacy Year and suggested actions are provided in the four following areas: (1) operative strategies for the realization of the International Literacy Year,…

  15. Guia para la ensenanza de la Lengua Nacional (segundo ano) (A Guide to the Teaching of the National Language (second year).

    ERIC Educational Resources Information Center

    Instituto Nacional de Pedagogia (Mexico).

    This document is an English-language abstract (approximately 1500 words) of a guide based on the results of experiments conducted by the Instituto Nacional de Pedagogia in its pilot school and other schools in Mexico, D. F. The foreword points out that there are two aspects of language teaching in elementary schools--the first year class to read…

  16. Financial Aid for Students Workbook, 1994-95 School Year = Ayuda Financiera para Estudiantes, Libreta del Ano Escolar 1994-95.

    ERIC Educational Resources Information Center

    California Student Aid Commission, Sacramento.

    Presented in both English and Spanish language formats, this workbook explains how California residents can qualify for and obtain student financial aid in the form of federal and state grants and loans, work-study programs, institutional grants, federal campus-based programs, and the Federal Family Education Loan Program loans. A calendar of…

  17. Guia para la ensenanza de la Lengua Nacional (segundo ano) (A Guide to the Teaching of the National Language (second year).

    ERIC Educational Resources Information Center

    Instituto Nacional de Pedagogia (Mexico).

    This document is an English-language abstract (approximately 1500 words) of a guide based on the results of experiments conducted by the Instituto Nacional de Pedagogia in its pilot school and other schools in Mexico, D. F. The foreword points out that there are two aspects of language teaching in elementary schools--the first year class to read…

  18. "Cien Anos de Soledad" y el concepto de la "Caida Afortunada" ("One Hundred Years of Solitude" and the Concept of the "Fortunate Fall")

    ERIC Educational Resources Information Center

    Dario Carrillo, German; Stults, Barry

    1972-01-01

    Shows the influence of R.W.B. Lewis' work about the fall of Adam on the Marquez novel. Marquez' view coincides with Lewis' that Adam's fall should be considered not as a lapse from divine favor, but as an actual rise to the normal human level. (DS)

  19. Literacy Learning Parties for 3-5 Year Olds. Activity Book = Fiestas de aprendizaje de alfabetismo para ninos de 3-5 anos. Libro de actividades.

    ERIC Educational Resources Information Center

    Daniels, Ellen R.

    Noting that family members are a child's first teachers and set the course for future success, this activity book of "literacy learning parties" presents 10 activities that can be used at home to practice the skills and ideas learned at parent literacy workshops. Presented in English and Spanish versions, the activity book discusses the importance…

  20. Guia para Padres Intervencion Temprana en Pennsylvania para Bebes desde el Nacimiento a los Tres Anos (A Parent Guide to Early Intervention in Pennsylvania for Infants and Toddlers).

    ERIC Educational Resources Information Center

    Parent Education Network, York, PA.

    This guide, in Spanish, is intended to help Pennsylvania parents of infants and toddlers with disabilities to understand their rights and assist in the design of an appropriate early intervention preschool educational program. An overview of special education laws focus on the Individuals with Disabilities Education Act, Parts B and C. The main…

  1. Swath Bathymetry Surveys of the Monterey Bay Area from Point Ano Nuevo to Moss Landing, San Mateo, Santa Cruz, and Monterey Counties, California

    USGS Publications Warehouse

    Ritchie, Andrew C.; Finlayson, David P.; Logan, Joshua B.

    2010-01-01

    This report describes swath bathymetry and backscatter data acquired by the U.S. Geological Survey on the continental shelf within the Monterey Bay National Marine Sanctuary between Point A?o Nuevo and Moss Landing, in San Mateo, Santa Cruz, and Monterey Counties, Calif. The survey was done for the California Seafloor Mapping Program (CSMP), in field activities S-7-09-MB and S-10-09-MB, by the Western Coastal and Marine Geology (WCMG) Team of the U.S. Geological Survey (USGS). The data were aquired in two seperate surveys: (1) between August 13, 2009 and September 3, 2009, personnel from WCMG completed field activity S-7-09-MB, from Point A?o Nuevo south to Table Rock, as well as a block west of Soquel Canyon; (2) between October 12 and December 16, 2009, WCMG conducted field activity S-10-09-MB, surveying between Table Rock and Moss Landing.

  2. Literacy Learning Parties for 3-5 Year Olds. Activity Book = Fiestas de aprendizaje de alfabetismo para ninos de 3-5 anos. Libro de actividades.

    ERIC Educational Resources Information Center

    Daniels, Ellen R.

    Noting that family members are a child's first teachers and set the course for future success, this activity book of "literacy learning parties" presents 10 activities that can be used at home to practice the skills and ideas learned at parent literacy workshops. Presented in English and Spanish versions, the activity book discusses the importance…

  3. Ministerio da Educacao e Cultura. Trinta Anos de Organizacao e Situacao Atual (Ministry of Education and Culture [Brazil]. Thirty Years Ago and Now). Volumes I and III.

    ERIC Educational Resources Information Center

    Porto, Norma Carneiro Monteiro

    The economic rather than the educational aspect of Brazil's Ministry of Education and Culture is presented in this historical summary. The study was done as part of Brazil's national program of educational reform. Brazil is currently re-evaluating its school system with the view of adopting a nationally-administered system similar to that in…

  4. The Meanings of Astronomical Observation: An Analysis on the Basis of Relationship with Knowledge. (Spanish Title: Los Sentidos de la Observación Astronómica: un Análisis sobre la Base de la Relación con el Saber.) Os Sentidos da Observação Astronômica: Uma Análise com Base na Relação com o Saber

    NASA Astrophysics Data System (ADS)

    Klein, Alberto Eduardo; de Mello Arruda, Sergio; Meneghello Passos, Marinez; Vinicius Domenes Zapparoli, Ferdinando

    2010-12-01

    This article presents results of a research which aimed to understand the meanings that people construct for astronomical observation. The subjects, students and school teachers, initially received some instruction on how to view astronomical objects through the telescope. After the observation was realized, they were interviewed. The data analysis allowed the creation of 12 categories, later interpreted on the basis of relationship with knowledge (relation to the world, with himself and with others), as presented by Bernard Charlot. Este artículo presenta los resultados de una investigación que tuvo como objetivo comprender los sentidos que las personas construyen para la observación astronómica. Los sujetos, los estudiantes y maestros de escuela, recibieron inicialmente algunas instrucciones sobre cómo ver los objetos astronómicos a través del telescopio. Al término de la observación, fueron entrevistados. El análisis de datos permitió la creación de 12 categorías que más tarde fueron interpretadas sobre la base de la relación con el conocimiento (relación con el mundo, consigo mismo y con los demás), tal como presentado por Bernard Charlot. Este artigo apresenta resultados de uma pesquisa que objetivou entender quais os sentidos que as pessoas constroem para a observação astronômica. Os sujeitos da pesquisa, estudantes e professores do ensino médio, receberam inicialmente alguma instrução sobre como visualizar os objetos astronômicos através do telescópio. Após a realização da observação, eles foram entrevistados. A análise dos dados permitiu a elaboração de 12 categorias que foram posteriormente interpretadas com base nas relações com o saber (relação com o mundo, consigo mesmo e com o outro), conforme apresentadas por Bernard Charlot.

  5. Molecular Toxicology of Chromatin

    DTIC Science & Technology

    1992-01-01

    FINAL 01 Jan 89 TO 31 Dec 91 4. ITL ANO SUS Y, L RE %UMAS MOLECULAR TOXICOLOGY OF CHROMATIN AFOSR-89-0231 PE - 61102F AUT PR - 2312 TA - A5 Dr Ernest Kun...Waterbury, CT), 2-mercaptoethanol, NAD+, NADPH, nucleo- tides, sodium tungstate , hydrogen peroxide, Tris and MES buffers from Sigma (St. Louis, MO...ml) with sodium tungstate (5.93 g, in 20 ml H20) for 1.5 h followed by extraction of the green product into ethyl acetate, washing with 0.1 N HCl, and

  6. Paradox of life among survivors of bladder cancer and treatments.

    PubMed

    Lopes, Miriam; Nascimento, Lucila Castanheira; Zago, Márcia Maria Fontão

    2016-04-01

    To interpret the meanings attributed to the experience of bladder cancer among survivors in therapeutic follow-up. Qualitative methodological approach, based on medical anthropology and narrative methodology. After approval by the research ethics committee of a public university hospital, data were collected from January 2014 to February 2015, by means of recorded semi-structured interviews, direct observation and field journal entries on daily immersion with a group of six men and six women, aged between 57 and 82 years, in therapeutic follow-up. Narratives were analyzed by means of inductive thematic analysis. The meanings revealed difficulties with the processes of disease and treatment, such as breakdown of normal life, uncertainty about the future due to possible recurrence of the disease, difficulty with continuity of care and emotional control, relating it to conflicting ways of understanding the present life. Thus, the meaning of this narrative synthesis is paradox. Interpretation of the meaning of experience with bladder cancer among patients provides nurses with a comprehensive view of care, which encompasses biological, psychological and social dimensions, and thereby systematizes humanized care. Interpretar o significado atribuído à experiência do câncer de bexiga entre sobreviventes em seguimento terapêutico. Empregou-se a abordagem metodológica qualitativa, embasado pela antropologia médica e método narrativo. Após aprovação do Comitê de Ética, os dados foram coletados de janeiro 2014 a fevereiro de 2015, por meio de entrevistas semiestruturadas gravadas, observação direta e registros no diário de imersão com grupo de seis homens e seis mulheres, entre 57 e 82 anos, em seguimento terapêutico em um hospital público universitário. As narrativas foram analisadas por meio da análise temática indutiva. Os sentidos revelam as dificuldades com o processo da doença e do tratamento, como rupturas na vida, futuro incerto pela

  7. Establishing the Empirical Relationship Between Non-Science Majoring Undergraduate Learners' Spatial Thinking Skills and Their Conceptual Astronomy Knowledge. (Spanish Title: Estableciendo Una Relación Empírica Entre el Razonamiento Espacial de los Estudiantes de Graduación de Carreras no Científicas y su Conocimento Conceptual de la Astronomía.) Estabelecendo Uma Relação Empírica Entre o RacioCínio Espacial dos Estudantes de Graduação EM Carreiras Não Científicas e Seu Conhecimento Conceitual da Astronomia

    NASA Astrophysics Data System (ADS)

    Heyer, Inge; Slater, Stephanie J.; Slater, Timothy F.

    2013-12-01

    normalizadas, en el desempeño de los estudiantes en estos dos asuntos foram pequenas, 0.26 e 0.13 respectivamente. El razonamiento espacial de los estudiantes fue medido utilizando un instrumento específico desarrollado para este trabaljo. Las correlaciones entre los resultados de los tests astronómicos y este instrumento específico, antes y después del curso mostraron una relación entre moderada y fuerte, sugiriendo que la relación entre el razonamiento espacial y el conocimiento astronómico puede explicar hasta un 25% de la variación em el desempeño de los estudiantes. A comunidade da educação em astronomia tem suposto de forma implícita que o aprendizado da astronomia consiste em um domínio conceitual fundamentado no raciocínio espacial. Como um primeiro passo para identificar formalmente uma relação empírica entre estas duas coisas, utilizamos como amostra os estudantes de graduação de carreiras não científicas de um curso exploratório em uma universidade norte-americana do meio-oeste de médio porte com programa de Doutorado em andamento, onde estes estudantes foram submetidos a um diagnóstico de raciocino espacial e conceitos astronômicos antes e depois do mesmo. As ferramentas utilizadas foram o Test Of Astronomy Standards (TOAST) e o questionário What do you know? Utilizando somente dados completamente consistentes para esta análise, nossa amostra consistiu de 86 estudantes de graduação. As melhoras, depois de normalizadas, do desempenho dos estudantes nos dois quesitos foram pequenas, 0.26 e 0.13 respectivamente. O raciocínio espacial dos estudantes foi medido utilizando um instrumento específico desenhado para este trabalho. As correlações entre os resultados dos testes astronômicos e este instrumento específico antes e depois do curso mostraram uma relação entre moderada e forte, sugerindo que a relação entre o raciocínio espacial e o conhecimento astronômico pode explicar até um 25% na variação no desempenho dos

  8. An Invited Preface for the Following Book: Astrobiologia, Uma Ciencia Emergente

    NASA Technical Reports Server (NTRS)

    Rothschild, Lynn J.

    2016-01-01

    Since the dawn of civilization, we have beheld at the beauty and wonder of the natural world around us and wondered how it came to be. We have pondered the past, and have been intrigued about the future. For this we are unique. Our ancestors looked to the vastness of space and thought surely there are others out there. We are now at a new time in human history where we can address these age-old questions with a scientific approach and study rigorously the three big questions of astrobiology: Where do we come from? Where are we going? and Are we alone? These fundamental questions of astrobiology correspond to those of humanity, and arguably, what makes us human. And so we cannot help but be drawn to the field. Unlike other scientific disciplines, Astrobiology draws on the latest advances in a multitude of fields, from evolutionary and molecular biology, to prebiotic and interstellar chemistry, from astrophysics to astronomy, with a healthy dose of earth and planetary science. Astrobiology is in reality a "metadiscipline" drawing on useful science wherever it is to be found. From a practical point of view, this endeavor requires the interaction of scientists who might not normally meet each other, much less work on a common research project. And, unlike most other scientific disciplines, Astrobiology has implications for how we see ourselves, and how we interact with the earth and beyond. "Where do we come from" touches on the "why" questions that have intrigued not just scientists but philosophers and theologians. "Where are we going" adds to these an economic and political involvement that is currently being played out with discussions of climate change. "And are we alone" will someday force us to face the fact that we as living creatures are not unique, or perhaps that we are utterly alone in the universe, the result of a chemical history that was so improbable as to result in a sample size of one. Either result will force ethical considerations of either "the other" and their relationship to us, or our solitude and thus responsibility as the only life form in our cosmos. So what is Astrobiology? Let's start with the "Where do we come from?" A biologist will approach this looking at the evolution of life on earth, using such traditional tools as comparative anatomy and paleontology and newer tools such as molecular techniques. But this doesn't address why this happened the way it did without a comprehensive understanding of the environment. What was the temperature at such and such a time? Was the earth in a snowball phase or being bombarded by meteorites -- or even just a single large, well-placed one such as struck off the Yucatan peninsula 65 million years ago. This event could not have been predicted by population genetics alone, yet it had the most profound influence on our evolution as without it, we could still be in a world dominated by dinosaurs with the mammals cowering under cover. But it is not enough to go back to LUCA, the Last Universal Common Ancestor of all extant life. One must go back to the dawn of life. How did life arise? What was the environmental backdrop that allowed it to happen? How did we happen to end up with a habitable planet? Indeed, what is the origin and evolution of our solar system, galaxy, biogenic elements all the way back to the Big Bang. The "Where are we going?" tends to be ignored in many astrobiology programs, but in fact this is of the most immediate importance to us. Whereas the past was dominated by physical and chemical processes, and organismal interactions, the future has a new major player: us. While we probably don't have the power (yet) to stop our galaxy passing through another, or even reset the sun or stop the movement of the moon away from the earth, all of these things will influence the future of life on earth. We are already proving that we have the power to visit other bodies in our solar system, either with humans or our robotic surrogates. We are changing our atmospheric composition and thus our climate. We have the power to render species extinct, including our own. But we also have the power to use these tools for the common good, to extend our lifetimes and reclaim our rivers and forests. Which will it be? And then there is the question where science fiction becomes a reality: "Are we alone?" While many people are anxious to find signs of intelligent life out there, such a creature may not share either our curiosity or values. But what if there was a beneficent alien civilization that could communicate with us, perhaps forging a mutual understanding? More likely in the forseeable future is finding a small life, less evolved, life form. Note I did not use the word "simple" as there is nothing "simple" about life, ever. Which brings us back to the question: what is life? So where does Brazil come in? For nearly a decade there has been interest in a Brazilian astrobiology program, from a small side meeting held by the Brazilian Exobiology Program (BEP) of the Brazilian National Research Council, held in Rio de Janeiro, Brazil, on August 12, 2009, in association with the IAU Assembly to subsequent workshops held in several locations and membership of the Brazilian program in the NASA Astrobiology Institute (NAI). Each time I go to Brazil, I am impressed by the enthusiasm of the community, both scientific and student, the latter an excellent omen for the future of astrobiology in Brazil. Facilities are being built to supplement the natural laboratories that Brazil is blessed to have. In my own lab I have been privileged to have a wonderful Brazilian postdoctoral fellow, Dr. Ivan Paulino-Lima, resulting in a daily reminder of the program. I am honored to have been part of the development of astrobiology in Brazil, and hope that this relationship will continue to flourish. Clearly to advance astrobiology needs new knowledge, a reorganization of that which is known, and space missions. To help the reader join on this quest, what follows is a buffet of topics that will allow the reader to nibble on the richness that is Astrobiology. And, like a fabulous meal, it should make you want more. Welcome to Astrobiology.

  9. CCD photometric analysis of the W UMa-type binary V376 Andromeda

    NASA Astrophysics Data System (ADS)

    Çiçek, C.

    2011-01-01

    This study presents the absolute parameters of the contact binary system V376 And. CCD photometric observations were made at the Çanakkale Onsekiz Mart University Observatory in 2004. The instrumental magnitudes of all observed stars were converted into standard magnitudes. New BV light curves of the system were analysed using the Wilson-Devinney method supplemented with a Monte Carlo type algorithm. Since there are large asymmetries between maxima (i.e., O'Connell effect) in these light curves, two different models (one with a cool spot and one with a hot spot) were applied to the photometric data. The best fit, which was obtained with a large hot spot on the secondary component, gives V376 And as an A sub-type contact binary in poor thermal contact and a small value of the filling factor ( f ≈ 0.07). Combining the solutions of our light curves and Rucinski et al. (2001)'s radial velocity curves, the following absolute parameters of the components were determined: M1 = 2.44 ± 0.04 M ⊙, M2 = 0.74 ± 0.03 M ⊙, R1 = 2.60 ± 0.03 R ⊙, R2 = 1.51 ± 0.02 R ⊙, L1 = 40 ± 4 L ⊙ and L2 = 5 ± 1 L ⊙. We also discuss the evolution of the system, which appears to have an age of 1.6 Gyr. The distance to V376 And was calculated as 230 ± 20 pc from this analysis, taking into account interstellar extinction.

  10. Model computations of blue stragglers and W UMa-type stars in globular clusters

    NASA Astrophysics Data System (ADS)

    Stȩpień, K.; Kiraga, M.

    2015-05-01

    Context. It was recently demonstrated that contact binaries occur in globular clusters (GCs) only immediately below turn-off point and in the region of blue straggler stars (BSs). In addition, observations indicate that at least a significant fraction of BSs in these clusters was formed by the binary mass-transfer mechanism. Aims: The aim of our present investigation is to obtain and analyze a set of evolutionary models of cool, close detached binaries with a low metal abundance, which are characteristic of GC. Methods: We computed the evolution of 975 models of initially detached, cool close binaries with different initial parameters. The models include mass exchange between components as well as mass and angular momentum loss due to the magnetized winds for very low-metallicity binaries with Z = 0.001. The models are interpreted in the context of existing data on contact binary and blue straggler members of GCs. The models are based on our recently developed code for evolutionary modeling of cool close and contact binaries. Results: The model parameters agree well with the observed positions of the GC contact binaries in the Hertzsprung-Russell diagram, and we achieve detailed parameters of several individual contact and near-contact binaries. Contact binaries in the lower part of the cluster main sequence are absent because there are no binaries with initial orbital periods shorter than 1.5 d. Contact binaries end their evolution as mergers that appear in the BS region. Binary-formed BSs populate the whole observed BS region in a GC, but a gap is visible between low-mass mergers that are concentrated along the zero-age main sequence and binary BSs occupying the red part of the BS region. Very few binary mergers are expected to rotate rapidly and/or possess chemical peculiarities resulting from the exposure of the layers processed by CNO nuclear reactions. All other binary mergers are indistinguishable from the collisionally formed mergers. The results show that binary-formed BSs may constitute at least a substantial fraction of all BSs in a GC. Tables 2-7 are available in electronic form at http://www.aanda.org

  11. An Orbital Period Investigation of the W UMa-Type Binary Y Sextantis

    NASA Astrophysics Data System (ADS)

    He, Jia-Jia; Qian, Sheng-Bang

    2007-12-01

    Four charge-coupled device (CCD) photometric times of light minimum of the overcontact binary Y Sex obtained from 2004 to 2007 are presented. It has been discovered that the light curve of Y Sex is variational. Combining the present times of light minimum with values collected from the literature, we investigated the orbital period changes of the system. It has been found that there may exist two cyclic period oscillations in the O - C diagram of Y Sex. One oscillates at a period of 51.22yr with an amplitude of 0.0218d, and the other changes at a period of 32.10yr with an amplitude of 0.0100d. The period oscillations can be explained either by the light-time effect via the presence of an unseen third body and an unseen fourth body or by magnetic-activity cycles of the components.

  12. Unified Multi-speed analysis (UMA) for the condition monitoring of aero-engines

    NASA Astrophysics Data System (ADS)

    Nembhard, Adrian D.; Sinha, Jyoti K.

    2015-12-01

    For rotating machinery in which speeds and dynamics constantly change, performing vibration-based condition monitoring can be challenging. Thus, an effort is made here to develop a Unified Multi-speed fault diagnosis technique that can exploit useful vibration information available at various speeds from a rotating machine in a single analysis. Commonly applied indicators are computed from data collected from a rig at different speeds for a baseline case and different faults. Four separate analyses are performed: single speed at a single bearing, integrated features from multiple speeds at a single bearing, single speed for integrated features from multiple bearings and the proposed Unified Multi-speed analysis. The Unified Multi-speed approach produces the most conspicuous separation and isolation among the conditions tested. Observations made here suggest integration of more dynamic features available at different speeds improves the learning process of the tool which could prove useful for aero-engine condition monitoring.

  13. Controls on lava lake level at Halema`uma`u Crater, Kilauea Volcano

    NASA Astrophysics Data System (ADS)

    Patrick, M. R.; Orr, T. R.

    2013-12-01

    Lava level is a fundamental measure of lava lake activity, but very little continuous long-term data exist worldwide to explore this aspect of lava lake behavior. The ongoing summit eruption at Kilauea Volcano began in 2008 and is characterized by an active lava lake within the eruptive vent. Lava level has been measured nearly continuously at Kilauea for several years using a combination of webcam images, laser rangefinder, and terrestrial LIDAR. Fluctuations in lava level have been a common aspect of the eruption and occur over several timescales. At the shortest timescale, the lava lake level can change over seconds to hours owing to two observed shallow gas-related processes. First, gas pistoning is common and is driven by episodic gas accumulation and release from the surface of the lava lake, causing the lava level to rise and fall by up to 20 m. Second, rockfalls into the lake trigger abrupt gas release, and lava level may drop as much as 10 m as a result. Over days, cyclic changes in lava level closely track cycles of deflation-inflation (DI) deformation events at the summit, leading to level changes up to 50 m. Rift zone intrusions have caused large (up to 140 m) drops in lava level over several days. On the timescale of weeks to months, the lava level follows the long-term inflation and deflation of the summit region, resulting in level changes up to 140 m. The remarkable correlation between lava level and deflation-inflation cycles, as well as the long-term deformation of the summit region, indicates that the lava lake acts as a reliable 'piezometer' (a measure of liquid pressure in the magma plumbing system); therefore, assessments of summit pressurization (and rift zone eruption potential) can now be carried out with the naked eye. The summit lava lake level is closely mirrored by the lava level within Pu`u `O`o crater, the vent area for the 30-year-long eruption on Kilauea's east rift zone, which is 20 km downrift of the summit. The coupling of these lava levels implies an efficient hydraulic connection between the summit and east rift zone vents. This connection has been indicated previously with geophysical data and is reinforced in a new quantitative manner with lava level data. Lastly, the current lava level at the summit is significantly lower than the mean level measured in the crater during continuous lava lake activity in the early 1900s. This is probably because the ongoing eruption at Pu`u `O`o 'taps' the magma supplied to the summit reservoir. Should the Pu`u `O`o eruption stop, the lava level at the summit would certainly rise in response. The precise correspondence between lava lake level and deformation of the summit implies that the lake level is a good indication of the pressure state of the magma reservoir. Tracking lava level over time may therefore provide an indication of the potential for future changes in eruptive activity. Such an observation has clear relevance for monitoring analogous open-vent basaltic volcanoes, especially where other measures of volcanic activity, like seismic or deformation measurements, may be lacking.

  14. Contact binary stars of the W UMa-type as distance tracers

    NASA Astrophysics Data System (ADS)

    Rucinski, Slavek M.

    2004-07-01

    Contact binaries can be used for distance determinations of stellar systems. They are easy to discover and identify and are very abundant among solar-type stars, particularly for MV>+3. The period-luminosity-colour (PLC) relations have similar properties to those for pulsating stars and can currently predict individual values of MV to about ±0.25 mag.

  15. Escola versus Televisao: Uma Questao de Linguagem (School versus Television: A Question of Language).

    ERIC Educational Resources Information Center

    Belloni, Maria Luiza

    1995-01-01

    Discusses the increasing presence of technology in social life and its effects on the educational processes. Presents research results about cognitive abilities and the "audiovisual language" typical of the younger generations. Discusses how to adapt the practice of education to these new requirements or necessities of the children who…

  16. First photometric study of the W UMa system GSC 1042-2191

    NASA Astrophysics Data System (ADS)

    Bulut, A.; Bulut, İ.; Demircan, O.

    2016-04-01

    We present new photometric observations covering eight minima times for the eclipsing binary GSC 1042-2191. The light curves in BVRI colors were analyzed by using WD-code for the system parameters. Eight minima times were obtained from the new observations. The system is found a low mass ratio (q = 0.148), A-type over-contact binary with a fill out parameter of f = 65.01 ± 12.18%. The preliminary absolute dimensions (M1= 1.26 ± 0.06 M⊙, M2 = 0.18 ± 0.06 M⊙, R1 = 1.54 ± 0.20 R⊙, R2 = 0.69 ± 0.01 R⊙, L1 =3.30 ± 0.30 L⊙ and L2 = 0.59 ± 0.20 L⊙) indicate the very much oversized and over-luminous secondary component, by assuming the present luminosity of the secondary is its main sequence luminosity, we predict the original mass is about 0.8 M⊙, this means the present secondary could be transferred and/or lost 77% of its original mass and only its core is left.

  17. Um satélite brasileiro para observação do diâmetro solar

    NASA Astrophysics Data System (ADS)

    Emilio, M.; Leister, N. V.; Benevides Soares, P.; Teixeira, R.; Kuhn, J.

    2003-08-01

    Propomos uma missão espacial para medir a forma e o diâmetro solar com o objetivo de ajudar a determinar o potencial gravitacional do Sol e a sua rotação com precisão, testar modelos teóricos de variação de energia e pela primeira vez medir os modos g de oscilação. As observações serão obtidas através do instrumento denominado APT (Astrometric and Photometric Telescope) descrito por Kuhn(1983). A sensibilidade do instrumento é de 0,2 mas em 27 dias para as observações do diâmetro solar feitas a cada minuto. Esta é uma missão de três anos de duração e pode complementar as medidas que serão feitas pelo satélite PICARD (a ser lançado em 2007). Outros parâmetros físicos podem ser obtidos com as mesmas imagens o que certamente interessará à comunidade de física solar. Um primeiro contato foi realizado com a agência espacial brasileira que pretende lançar um satélite científico a cada dois anos.

  18. [Efficacy of the Vaccines Against Human Papillomavirus in Women Older than 24 Years in the Cervix Cancer Prevention].

    PubMed

    Pimenta Ribeiro, Jaime; Borges, Isabel

    2016-06-01

    Introdução: O cancro do colo do útero é o quarto tipo de cancro feminino mais comum e o segundo mais frequente nas mulheres entre os 15 e os 44 anos. A infeção pelo vírus do papiloma humano é condição necessária na quase totalidade dos casos de cancro do colo do útero; trata-se de uma doença sexualmente transmissível e todas as mulheres sexualmente ativas estão em risco de contrair infeção. Atualmente existem três vacinas contra o vírus do papiloma humano, e apesar da sua eficácia estar bem comprovada nas mulheres até aos 25 anos, não está totalmente estabelecida em idades superiores.Material e Métodos: Realizou-se uma revisão da literatura sobre a evidência atual relativa à eficácia das vacinas contra o vírus do papiloma humano nas mulheres com mais de 24 anos na prevenção do cancro do colo do útero e foi avaliada a qualidade da evidência segundo o sistema GRADE.Resultados: Foram identificados dois estudos controlados randomizados relevantes para a análise que envolveram um total de 9 571 participantes – 4 792 no grupo vacinado e 4 779 no grupo controlo – e reportaram dados relativos a 48 meses de follow-up. A redução do risco relativo foi de 41% (95% CI: 29 a 50%), – favorável para o grupo vacinado. Não existiram diferenças entre a segurança e tolerabilidade das vacinas nos grupos vacina e controlo.Conclusão: A evidência atual demonstra que as vacinas contra o vírus do papiloma humano 16 e/ou 18 nas mulheres com mais de 24 e até aos 45 anos apresentam uma eficácia importante na redução do risco de desenvolver infeção persistente e/ou adquirir lesões precursoras de cancro do colo do útero.

  19. [Anogenital Warts in a Major Venereology Clinic: Centro de Saúde da Lapa - Lisbon, 2008 to 2014].

    PubMed

    Gameiro, Ana; Alves, João; Santo, Irene; Azevedo, Jacinta

    2016-02-01

    Introdução: O vírus do papiloma humano é responsável pela infeção sexualmente transmissível mais comum, podendo manifestar--se por um conjunto amplo de doenças, nomeadamente condilomas anogenitais, papilomatose laríngea recorrente, e neoplasias da região anogenital, colo do útero e orofaringe. Estima-se que os condilomas anogenitais afetem 1% da população sexualmente ativa, causados em cerca de 90% pelos genótipos 6 e 11. Material e Métodos: Identificámos os doentes com primeiro diagnóstico de condilomas anogenitais da consulta de doenças sexualmente transmissíveis do Centro de Saúde da Lapa, entre janeiro de 2008 e dezembro de 2014, e caracterizámos os doentes por sexo, orientação sexual, idade, localização das lesões, e número de parceiros nos últimos seis meses. Resultados: Foram identificados 902 indivíduos com primeiro diagnóstico de condilomas anogenitais. Observámos uma diminuição significativa de novos casos nas mulheres com < 19 anos (r = -0,848; p = 0,016), e uma diminuição sem significado estatístico nos homens com < 19 anos e nas mulheres entre os 20 - 24 anos. Discussão: Em outubro de 2008, a vacina quadrivalente (genótipos 6, 11, 16, 18) foi introduzida no plano nacional de vacinação de Portugal, abrangendo as adolescentes com 13 anos, com um catch-up para as de 17 anos. A diminuição de primeiros diagnósticos de condilomas anogenitais nas mulheres, deve-se provavelmente à sua vacinação antes de iniciarem a vida sexual. Conclusão: Este estudo reforça a import'ncia do programa nacional de vacinação para o vírus do papiloma humano.

  20. [Epidemiology of Vertigo on Hospital Emergency].

    PubMed

    Roque Reis, Luis; Lameiras, Rita; Cavilhas, Pedro; Escada, Pedro

    2016-05-01

    Introdução: A vertigem é um dos motivos mais frequentes na procura de atendimento médico especializado na urgência. O objetivo deste estudo foi avaliar o peso real que as alterações do equilíbrio têm na urgência de Otorrinolaringologia, as suas características epidemiológicas e uma eventual sazonalidade por estações do ano. Usou-se uma amostra de doentes que utilizou o serviço de urgência desta especialidade de um hospital central universitário de Lisboa durante um período de quatro anos. Material e Métodos: O projeto foi concebido como um estudo epidemiológico descritivo de tipo populacional, retrospectivo, no período de 2010 a 2013. Incluiu uma população total de 40 173 atendimentos de doentes que nesse período utilizou o serviço de urgência de Otorrinolaringologia. As variáveis estudadas incluíram a idade, género, número anual de casos (total e percentual), data da crise de vertigem, distribuição sazonal por estações do ano e proporção anual de casos internados. Resultados: Um total de 4 347 doentes (10,8%) procurou atendimento médico devido a vertigem ou alterações do equilíbrio ao longo dos quatro anos do estudo. Verificou-se um aumento anual do número de casos entre 7,6% (em 2010) a 17% (em 2013). As mulheres foram mais frequentemente afetadas (68,3%) e as crises ocorreram mais frequentemente em indivíduos entre os 60 e 79 anos de idade (40%). Os casos distribuíram-se de forma heterogénea entre as estações do ano, havendo mais episódios de vertigem no verão e no outono e com uma tendência crescente entre 2010 e 2013. O número de internamentos aumentou anualmente nesse período. Discussão: A epidemiologia da vertigem e dos distúrbios vestibulares específicos é ainda um campo a estudar, pois pode ter utilidade para a tomada de decisões clínicas e para o planeamento dos cuidados de saúde. Conclusão: O estudo revelou que os casos de vertigem na urgência aumentaram anualmente e são mais frequentes no sexo

  1. Cost-effectiveness analysis of paricalcitol versus calcitriol for the treatment of SHPT in dialytic patients from the SUS perspective.

    PubMed

    Menezes, Fabiana Gatti de; Abreu, Rodrigo Martins; Itria, Alexander

    2016-01-01

    ções nas taxas séricas de cálcio, fósforo e do produto cálcio-fósforo. Este trabalho tem como objetivo desenvolver uma análise de custo-efetividade de paricalcitol versus calcitriol para pacientes em diálise com HPTS, perspectiva do SUS. Foi desenvolvido um modelo de decisão de Markov para a população ≥ 50 anos, com DRC em diálise e HPTS. Foram considerados ciclos trimestrais e um horizonte temporal lifetime. O desfecho clínico avaliado foram os anos de vida ganhos. Dados foram obtidos a partir de revisão sistemática da literatura e bases de dados oficiais. Custos em reais (R$), ano de 2014. No caso base: paricalcitol gerou benefício clínico de 16,28 anos de vida ganhos versus 14,11 anos de vida ganhos com calcitriol, custos totais de R$ 131.064 e R$ 114.262, respectivamente. A razão de custo-efetividade incremental de R$ 7.740 por ano de vida salvo. Dados robustos confirmados pela análise de sensibilidade. De acordo com o limiar de custo-efetividade recomendado pela Organização Mundial de Saúde para o ano de 2013, o tratamento de pacientes com HPTS em diálise com paricalcitol é custo-efetivo, comparado ao calcitriol, perspectiva SUS.

  2. Inauguração do Telescópio SOAR

    NASA Astrophysics Data System (ADS)

    Steiner, João

    2004-04-01

    A comunidade astronômica brasileira de há muito almeja ter a sua disposição um instrumento científico com o qual possa fazer pesquisa de vanguarda e manter a competitividade científica a nível internacional. Hoje este sonho se torna uma realidade. O Brasil tem tido uma política de pesquisa e de pós-graduação bem sucedida. Estamos formando 7000 doutores por ano e produzimos 1,5% da ciência mundial. Nosso desafio, hoje, é associar a esta capacidade de gerar conhecimento também a capacidade de usar o conhecimento em beneficio da sociedade. A Astronomia não é exceção. Temos 7 programas de pós-graduação em nível de doutorado e 11 em nível de mestrado. O telescópio SOAR será o principal instrumento que sustentará estes programas nas próximas décadas. A inauguração do telescópio SOAR simboliza de forma concreta e decidida o apoio do MCT, do CNPq e da FAPESP para o financiamento à pesquisa básica em nosso país. O Laboratório Nacional de Astrofísica, criado a cerca de 20 anos pelo CNPq, a par do Laboratório Nacional de Luz Sincrotron, são até hoje, os únicos laboratórios nacionais do Brasil e ambos voltados basicamente ao avanço do conhecimento. Os vinte anos de existência do LNA foram decisivos para a estruturação da comunidade astronômica no Brasil e para a construção das parcerias como o SOAR.

  3. Economic analysis of rivaroxaban for the treatment and long-term prevention of venous thromboembolism in Portugal.

    PubMed

    Santos, Isabel Fonseca; Pereira, Sónia; McLeod, Euan; Guillermin, Anne-Laure; Chatzitheofilou, Ismini

    2014-01-01

    Introdução: O tromboembolismo venoso representa uma carga substancial para os sistemas de saúde. O objectivo foi estimar os resultados clínicos e económicos a longo-prazo associados a rivaroxabano relativamente à prática clínica (enoxaparina/varfarina) no tratamento e prevenção secundária de tromboembolismo venoso em Portugal.Material e Métodos: Foi desenvolvido um modelo de Markov baseado nos ensaios clínicos EINSTEIN e dados da literatura para complicações a longo-prazo. Foram avaliados custos e anos de vida ajustados pela qualidade de vida totais e incrementais e rácio custo-efectividade incremental. As indicações trombose venosa profunda e embolismo pulmonar foram analisados separadamente. Adoptou-se a perspectiva da sociedade portuguesa e um horizonte temporal de cinco anos. Aplicou-se uma taxa de actualização de cinco por cento para custos e consequências. Foram desenvolvidas análises de sensibilidade e diversas análises de cenário para avaliação da variação dos resultados em função de determinados pressupostos.Resultados: Rivaroxabano está associado a menores custos na trombose venosa profunda e constitui uma alternativa associada a menores custos e a maior eficácia no tratamento de embolismo pulmonar, relativamente a enoxaparina/varfarina.Discussão: O recurso a um painel de peritos para identificação de alguns recursos e a ausência de utilidades específicas para Portugal constituem as principais limitações.Conclusão: Rivaroxabano constitui uma alternativa eficaz, estando associado a menores custos (para ambas as indicações) e a mais anos de vida ajustados pela qualidade de vida (para embolismo pulmonar) relativamente a enoxaparina/varfarina em Portugal.

  4. Análise sobre o Conhecimento de um Grupo de Alunos do Ensino Médio da Rede Estadual de São Paulo sobre Termos e Fenômenos Astronômicos do Cotidiano

    NASA Astrophysics Data System (ADS)

    de Oliveira, E. F.; Voelzke, M. R.; Amaral, L. H.

    2007-08-01

    Embora os Parâmetros Curriculares Nacionais do Ensino Médio (PCN-EM) e as orientações complementares a esses Parâmetros (PCN+) apontem a importância de uma abordagem significativa de conceitos relacionados à astronomia nas aulas de Física, muitos estudantes terminam o Ensino Médio (EM) sem compreender a razão de certos acontecimentos de origem celeste, ainda que estes façam parte de seu cotidiano. Este trabalho tem por objetivo analisar os conhecimentos básicos em astronomia dos alunos de EM da escola estadual Batista Renzi, bem como investigar os meios através dos quais estes conhecimentos foram adquiridos. Para tanto foi elaborado um questionário de múltipla escolha aplicado a 310 alunos distribuídos entre as três séries do EM dos períodos matutino e noturno. Dessa forma, observou-se que apenas 34,5% relacionaram as estações do ano à inclinação do eixo de rotação da Terra, 21,3% indicaram a influência gravitacional da Lua e do Sol como responsáveis pelo fenômeno das marés, 24,5% indicaram corretamente quais são os objetos celestes mais próximos da Terra, 36,1% identificaram ano-luz como uma medida de distância e 34,2% reconheceram uma estrela cadente como meteoro. Em contrapartida, 67,1% compreendiam a sucessão entre dia e noite, 73,9% identificaram o Sol como estrela e 52,3% relacionaram o Big Bang à origem do Universo. Além disso, foram comparadas as respostas de alunos de diferentes séries e períodos, observando-se, dentre outras coisas, que os estudantes do terceiro ano apresentam um percentual de acertos semelhante ao dos alunos do primeiro, caracterizando que a abordagem de tópicos relacionados à astronomia no EM não tem contribuído para uma maior compreensão dos fenômenos e conceitos.

  5. A proposed contents astronomy for basic education

    NASA Astrophysics Data System (ADS)

    Albrecht, E.; Voelzke, M. R.

    2014-08-01

    A Astronomia é um tema que sempre exerceu fascínio sobre as pessoas de um modo geral. Conhecer e estudar o que há nos “céus”, além de nossos olhos, continua sendo instigador e de grande interesse. Baseado nestas justificativas desenvolveu-se uma pesquisa de Doutorado, na qual, o objetivo principal foi investigar sobre a presença dos conteúdos de Astronomia nas Propostas Curriculares da região Sul do Brasil, a saber, os estados de Paraná, Rio Grande do Sul e Santa Catarina e, posterior comparação com os Parâmetros Curriculares Nacionais (PCN) que trazem propostas de conteúdos para toda a Educação Básica brasileira. Tal investigação pautou-se na abordagem de caráter qualitativo e utilizouse para tal da Análise de Conteúdos (Bardin, 2011), que possibilitou a construção de quatro categorias, nas quais os conteúdos astronômicos foram agrupados: Terra, Sistema Solar, Via Láctea e Universo. Após a leitura, coleta de dados, construção de categorias, observou-se a dicotomia na apresentação destes conteúdos. As propostas curriculares analisadas foram as de Geografia, Ciências e Física dos estados do Paraná (2008), Rio Grande do Sul (2009) e de Santa Catarina (1998), responsáveis pelo trabalho com Astronomia nestes estados. No Ensino Fundamental, a proposta curricular do estado do Paraná apresenta conteúdos ligados à Astronomia desde o sexto ano até o nono ano, como conteúdo do primeiro bimestre, o que também é apresentado na proposta curricular do estado do Rio Grande do Sul, porém, este, não divide os conteúdos por bimestre e nem por ano, mas por ciclos, sexto e sétimo anos como primeiro ciclo e oitavo e nono anos como segundo ciclo, deixando livre para o professor estruturar sua sequência de conteúdos. A proposta curricular de Santa Catarina não apresenta estes conteúdos de maneira explícita, não divide dos conteúdos nem por ano, nem por série, traz uma sequência de conteúdos para serem trabalhados ao longo dos

  6. [Alcohol consumption in the schooled youth: an old question revisited].

    PubMed

    Marques, Marilia; Viveiro, Carolina; Passadouro, Rui

    2013-01-01

    Introdução: É principalmente na adolescência que os jovens procuram novas experiências. O consumo de álcool surge neste contexto como uma atitude banalizada e, por vezes, até incitada socialmente, já que o acesso a bebidas alcoólicas é facilitado. Associa-se a comportamentos de risco, com consequências sérias do ponto de vista de saúde pública. O nosso objectivo é caracterizar os padrões de consumo de álcool numa amostra de adolescentes residentes no distrito de Leiria. Material e Métodos: Estudo transversal, descritivo, através de um questionário anónimo aplicado em alunos do distrito de Leiria. Resultados: A amostra final foi de 405 indivíduos, 56% do sexo feminino, com idade média de 16,5 ± 1 anos (15 - 18 anos). A maioria (48%) frequentava o 10º ano, 15,4% reprovaram pelo menos uma vez. Noventa por cento dos inquiridos afirmaram ter experimentado bebidas alcoólicas pelo menos uma vez. O primeiro contacto com o álcool ocorreu preferencialmente com amigos (63%), na maioria dos casos por curiosidade (47%). Os resultados apontaram para maiores índices de consumo de cerveja e maior insucesso escolar no género masculino, comparativamente ao género feminino, que apresentava um maior consumo de bebidas brancas. Em ambos os sexos verificou-se uma tendência para o binge drinking. A maioria dos inquiridos (60%) consumia 2 a 3 copos por ocasião mas cerca de 30% dos rapazes afirmaram consumir mais de quatro copos por ocasião (7% até ficarem embriagados), tendência que não se verificou nas raparigas. A maioria dos consumos efectuou-se nos bares e discotecas (60%). Constatou-se que 41% dos inquiridos saíam à noite, e 70% ingeriam bebidas alcoólicas; 66% começaram a sair à noite entre os 13 e os 15 anos de idade e 9% já tinham experimentado drogas pelo menos uma vez. Os jovens estão mal informados quanto ao consumo do álcool: 20% achavam que as bebidas alcoólicas podem matar a sede, 34% acreditavam que abrem o apetite, 15

  7. Retained Textile Foreign Bodies: Experience of 27 Years.

    PubMed

    Arikan, Soykan; Kocakusak, Ahmet

    2015-01-01

    Introdução e Objetivos: A retenção de materiais têxteis após a cirurgia é uma situação indesejada, tanto para o doente como para o cirurgião. Frequentemente são subnotificados por questões de natureza médico-legal. Apresentamos 14 casos de textilomas (compressoma) que foram tratados ou seguidos pessoalmente por dois cirurgiões gerais num período de 27 anos para descrever e definir as características clínicas e patológicas. Material e Métodos: Foram avaliados retrospectivamente os dados relativos a uma serie de casos, nomeadamente: características dos doentes (sexo e idade), localização anatómica do corpo estranho, intervalo de tempo até ao diagnóstico, apresentação clínica, queixas, abordagem diagnóstica, motivo de cirurgia, tipo de tratamento cirúrgico e complicações. Resultados: Foram identificados nove doentes do sexo feminino e cinco do sexo masculino, com uma média de idades de 43,07 ± 15,23 (mediano: 45) anos para o momento do diagnóstico. Em três doentes a cirurgia prévia foi cesariana, em quatro casos herniorrafia inguinal, um doente submetido a laparotomia exploradora por abdome agudo, um doente no qual foi realizado uma sigmoidectomia, uma doente submetida a apendicectomia e salpingooforectomia direita, uma doente na qual a cirurgia anterior tinha sido para corrigir uma hérnia incisional após laparotomia por neoplasia do ovário, um caso de tiroidectomia total, uma herniorrafia por hérnia epigástricae uma doente submetida cirurgia conservadora bilateral da mama com pesquisa de gânglio sentinela. A localização mais frequente dos compressomas foi intra-abdominal em sete casos, em quatro doentes a localização foi inguinal, um caso localizado na incisão da correcção da hérnia epigástrica, um doente com textiloma na loca de tiroidectomia, e no caso da doente submetida a cirurgia conservadora da mama em ambas regiões axilares se encontraram corpos estranhos/compressomas. O intervalo de tempo foi em média14

  8. Oral health in the agenda of priorities in public health.

    PubMed

    Antunes, José Leopoldo Ferreira; Toporcov, Tatiana Natasha; Bastos, João Luiz; Frazão, Paulo; Narvai, Paulo Capel; Peres, Marco Aurélio

    2016-09-01

    This study describes the scientific production on oral health diffused in Revista de Saúde Pública, in the 50 years of its publication. A narrative review study was carried out using PubMed, as it is the search database that indexes all issues of the journal. From 1967 to 2015, 162 manuscripts specifically focused on oral health themes were published. This theme was present in all volumes of the journal, with increasing participation over the years. Dental caries was the most studied theme, constantly present in the journal since its first issue. Periodontal disease, fluorosis, malocclusions, and other themes emerged even before the decline of dental caries indicators. Oral health policy is the most recurring theme in the last two decades. Revista de Saúde Pública has been an important vehicle for dissemination, communication, and reflection on oral health, contributing in a relevant way to the technical-scientific interaction between professionals in this field. RESUMO Este estudo descreve a produção científica sobre saúde bucal veiculada na Revista de Saúde Pública, nos cinquenta anos de sua publicação. Foi realizado estudo de revisão narrativa, utilizando o PubMed como mecanismo de busca que indexa todos os fascículos da revista. De 1967 a 2015, foram publicados 162 manuscritos com foco específico em temas de saúde bucal. Essa temática esteve presente em todos os volumes da revista, com participação crescente ao longo dos anos. Cárie dentária foi o tema mais estudado, marcando presença constante na revista desde seu primeiro fascículo. Doença periodontal, fluorose, oclusopatias e outros temas emergiram antes mesmo do declínio dos indicadores de cárie. Políticas de saúde bucal é o tema mais recorrente nas duas últimas décadas. A Revista de Saúde Pública tem sido importante veículo de divulgação, comunicação e reflexão sobre saúde bucal, contribuindo de modo relevante para a interação técnico-científica entre os

  9. Pacemaker Implants in Children and Adolescents with Chagas Disease in Brazil: 18-Year Incidence.

    PubMed

    Mizzaci, Carolina Christianini; Souza, Thiago Gonçalves Schroder E; Targueta, Gabriel Pelegrineti; Tótora, Ana Paula Frederico; Mateos, Juan Carlos Pachón; Mateos, José Carlos Pachon

    2017-06-01

    ções coletadas pelo Registro Brasileiro de Marca-passo. As variáveis analisadas foram: ano do implante, localidade, idade, sexo, grupo étnico dos pacientes; classificação funcional e os principais achados eletrocardiográficos de base. Em um total de 183 123 implantes realizados entre 1994 e 2011, foram identificados 214 implantes de dispositivos de estimulação cardíaca em portadores de doença de Chagas com idade inferior a 18 anos. A média de idade no momento do implante foi de 5,6 ± 6,2 anos. Bloqueios atrioventriculares de 2º e 3º graus foram responsáveis por 71% das indicações. Dos procedimentos, 55,6% foram realizados na região sudeste. Em relação ao total de implantes de marca-passo por ano, observamos um aumento importante e significante de implante por todas as causas. Entretanto, quando avaliamos a série temporal de implantes em pacientes com doença de Chagas menores que 18 anos, observamos uma redução expressiva e significativa no número anual de implantes. Observa-se uma redução importante do número de implantes de marca-passo em crianças e adolescente chagásicos, o que sugere uma redução da transmissão vertical do parasita.

  10. [Peritoneal Dialysis in the First Two Years of Life: Experience of a Nephrology and Renal Transplantation Pediatric Unit].

    PubMed

    Deuchande, Sofia; Mano, Tânia; Novais, Cristina; Machado, Rute; Stone, Rosário; Almeida, Margarida

    2016-09-01

    Introdução: A diálise peritoneal é o método dialítico de eleição perante doença renal crónica terminal em idade pediátrica. O objetivo deste estudo foi caracterizar a sobrevivência a longo prazo de uma população de crianças, que iniciou diálise peritoneal nos dois primeiros anos de vida. Material e Métodos: Estudo descritivo e retrospetivo, realizado numa unidade de nefrologia e transplantação renal pediátrica portuguesa, no período de janeiro de 1991 a agosto de 2014. Avaliou-se etiologia da doença renal crónica terminal, mortalidade, comorbilidades e complicações da diálise peritoneal e da doença renal crónica terminal, crescimento e desenvolvimento psicomotor.Resultados: Vinte crianças iniciaram diálise peritoneal antes dos dois anos. Ocorreram seis óbitos; não houve mortalidade em crianças com doença renal primária nos últimos 10 anos. Caracterizaram-se os 14 sobreviventes, 13 do sexo masculino. As anomalias congénitas do rim e do trato urinário constituíram a principal causa de doença renal crónica terminal (45%).O início de diálise peritoneal ocorreu em média aos 6,1 meses, em seis casos antes dos 30 dias de vida. A peritonite foi o motivo mais frequente de internamento. Dez crianças foram transplantadas, com idade média de 5,3 anos. Em relação ao crescimento, as quatro crianças que se mantêm em diálise peritoneal têm baixa estatura, mas nove dos transplantados têm uma estatura final dentro do esperado para a sua estatura-alvo familiar. Nove (64%) tiveram alterações no desenvolvimento psicomotor. Discussão: A diálise peritoneal é uma técnica possível e exequível desde o nascimento, tal como evidenciado nesta amostra, em que se iniciou com sucesso em mais de metade das crianças antes dos seis meses de vida. Permite uma sobrevivência a longo prazo até à possibilidade do transplante renal apesar da morbilidade associada, nomeadamente as peritonites e as complicações da doença renal

  11. National Migrant Education Program: Early Childhood Development Skills--Birth Through 5 Years (Desarrollo de Destrezas en la Temprana Infancia--Desde el Nacimiento Hasta los Cinco Anos de Edad).

    ERIC Educational Resources Information Center

    1979

    Compiled to ensure cooperation between states and to provide continuity of reporting on developmental skills for the migrant child from birth through five years of age, this booklet lists the psychomotor, cognitive, and affective skills which are reported through the Migrant Student Record Transfer System (MSRTS). Published in both English and…

  12. What to Teach Your Child: A Handbook for Parents of 4-6 Year Olds. (Lo Que Pueden Ensenarles a Los Ninos: Un Manual Para Padres De Ninos De 4 A 6 Anos).

    ERIC Educational Resources Information Center

    Wile, Elizabeth M.

    Prepared specifically for parents of children ages 4 to 6, this brief guide (available in English or Spanish) provides basic information about what basic skills children should master, and how parents can help them acquire these skills. Ideas and suggestions are given for teaching such basic skills as controlling large and small muscles,…

  13. Como ayudar a su hijo a ser un buen lector: Con actividades para los ninos desde el nacimiento hasta los 6 anos (Helping Your Child Become a Reader: With Activities for Children from Infancy through Age 6).

    ERIC Educational Resources Information Center

    Lehr, Fran; Osborn, Jean

    When parents and other family members read with their children, help them with homework, talk with their teachers, and participate in school or other learning activities, they give their children a tremendous advantage. The foundation for learning to read is in place long before children enter school and begin formal reading instruction. Families…

  14. What to Teach Your Child: A Handbook for Parents of 4-6 Year Olds. (Lo Que Pueden Ensenarles a Los Ninos: Un Manual Para Padres De Ninos De 4 A 6 Anos).

    ERIC Educational Resources Information Center

    Wile, Elizabeth M.

    Prepared specifically for parents of children ages 4 to 6, this brief guide (available in English or Spanish) provides basic information about what basic skills children should master, and how parents can help them acquire these skills. Ideas and suggestions are given for teaching such basic skills as controlling large and small muscles,…

  15. Effect of Spin-Orbit Coupling on the Actinide Dioxides AnO2 (An=Th, Pa, U, Np, Pu, and Am): A Screened Hybrid Density Functional Study

    SciTech Connect

    Wen, Xiaodong; Martin, Richard L.; Roy, Lindsay E.; Scuseria, Gustavo E.; Rudin, Sven P.; Batista, Enrique R.; McCleskey, Thomas M.; Scott, Brian L.; Bauer, Eve; Joyce, John J.; Durakiewicz, Tomasz

    2012-10-21

    We present a systematic comparison of the lattice structures, electronic density of states, and band gaps of actinide dioxides, AnO₂ (An=Th, Pa, U, Np, Pu, and Am) predicted by the Heyd-Scuseria-Ernzerhof screened hybrid density functional (HSE) with the self-consistent inclusion of spin-orbit coupling(SOC). The computed HSE lattice constants and band gaps of AnO₂ are in consistently good agreement with the available experimental data across the series, and differ little from earlier HSE results without SOC. ThO₂ is a simple band insulator (f⁰), while PaO₂, UO₂, and NpO₂ are predicted to be Mott insulators. The remainders (PuO₂ and AmO₂) show considerable O2p/An5f mixing and are classified as charge-transfer insulators. We also compare our results for UO₂, NpO₂, and PuO₂with the PBE+U, self interaction correction (SIC), and dynamic mean-field theory (DMFT) many-body approximations.

  16. Como ayudar a su hijo a tener exito en la escuela, con actividades para ninos entre las edades de 5 a 11 anos (Helping Your Child Succeed in School, with Activities for Children Ages 5 through 11).

    ERIC Educational Resources Information Center

    Paulu, Nancy

    At the heart of the No Child Left Behind Act of 2001 is a promise to raise standards for all children and to help all children meet those standards. This Spanish-language booklet provides information that parents can use to help their child succeed in school. Following an introduction, the second section of the booklet, "The Basics," offers…

  17. Como ayudar a su hijo durante la edad preescolar, con actividades para los ninos desde el nacimiento hasta los 5 anos (Helping Your Preschool Child, with Activities for Children from Infancy through Age 5).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC. Office of Intergovernmental and Interagency Affairs.

    The first 5 yeas of a child's life are a time of tremendous physical, emotional, social, and cognitive growth. Noting that research shows that children are more likely to succeed in learning when their families actively support them, this Spanish-language booklet is intended for families and caregivers who want to help their preschool children…

  18. International Symposium on Visually Handicapped Infants and Young Children: Birth to Seven (2nd, Aruba, 1987). "The First Steps." Proceedings = Simpasio Internacional sobre Ninos Visualmente Deficientes de Nacimiento hasta Siete Anos (2nd, Aruba, 1987). "Los Primeros Pasos."

    ERIC Educational Resources Information Center

    Palmer, Lillian, Ed.; And Others

    This symposium focused on the special needs of visually handicapped infants and young children. Texts of 48 papers are presented, including keynote addresses by W. Aubrey Webson ("The First Steps") and Heather Hewitt ("First Steps--Parenting, Prevention and Programming"). Regional reports are provided for Japan, Bangladesh, the…

  19. El buen comienzo de la lectura: Lo que pueden hacer los padres durante los primeros cinco anos (Reading Right from the Start: What Parents Can Do in the First Five Years).

    ERIC Educational Resources Information Center

    Bickart, Toni S.; Dodge, Diane Trister

    Intended to provide concrete ways for parents to help children become readers and writers, this Spanish-language, easy-to-read, illustrated booklet uses the everyday routines that parents follow with their children--bathing and dressing, eating, shopping, doing household chores--to demonstrate how to build vocabulary, learn about conversations,…

  20. Little Steps for New Parents: A Week-by-Week Guide and Journal for Baby's First Year = Pasitos para nuevos padres: Una guia y diario semanal para el primer ano del bebe.

    ERIC Educational Resources Information Center

    Briggs, Sandy

    Providing young infants with a loving and interesting environment through play will have a positive impact on their future. This book, designed for first time parents, provides simple and enjoyable activities intended to promote brain development during the first year. The book's introduction discusses the importance of the environment during the…

  1. National Migrant Education Program: Early Childhood Development Skills--Birth Through 5 Years (Desarrollo de Destrezas en la Temprana Infancia--Desde el Nacimiento Hasta los Cinco Anos de Edad).

    ERIC Educational Resources Information Center

    1979

    Compiled to ensure cooperation between states and to provide continuity of reporting on developmental skills for the migrant child from birth through five years of age, this booklet lists the psychomotor, cognitive, and affective skills which are reported through the Migrant Student Record Transfer System (MSRTS). Published in both English and…

  2. Tão perto de casa, tão longe de nós: etnografia das novas margens no centro da urbe

    PubMed Central

    Fernandes, Por Luís

    2011-01-01

    Philippe Bourgois é, desde 2007, “Richard Perry University professor” no Departamento de Antropologia e de Medicina Familiar e de Práticas Comunitárias na Universidade da Pensilvânia. Esteve durante largos anos ligado ao Departamento de Antropologia, História e Medicina Social da Universidade da Califórnia, São Francisco. A publicação, em 1995, de In Search of Respect: Selling Crack in El Barrio1 projectaria o seu nome muito para além dos Estados Unidos: uma etnografia no coração porto-riquenho do Harlem, em torno dos actores e dos ambientes da venda de crack. Seguir-se-ia um longo trabalho de terreno em acampamentos de dependentes de heroína em São Francisco, orientando o seu trabalho para as formas mais radicais da pobreza e da marginalidade nos EUA. É deste trabalho de terreno que sai o seu último livro, Righteous Dopefiend2. Em Junho de 2007 esteve em Lisboa para participar na 3.a edição do “Ethnografeast”. Foi então que aproveitámos a oportunidade para ouvir um percurso invulgar contado pelo próprio: uma longa conversa no Hotel Zurique, cujo nome só vem ao caso por evocar o país onde passou uma parte da infância. PMID:22013286

  3. [Surgical Treated Spondylodiscitis Epidemiological Study].

    PubMed

    Soares do Brito, Joaquim; Tirado, António; Fernandes, Pedro

    2016-05-01

    Introdução: O termo espondilodiscite descreve uma qualquer infeção da coluna vertebral, sendo o tratamento gold standard baseado na terapêutica médica e a indicação cirúrgica ponderada em casos particulares. Foi objetivo deste trabalho estudar o perfil epide-miológico de um grupo de doentes com espondilodiscite submetidos a tratamento cirúrgico numa mesma instituição nacional entre 1997 e 2013. Material e Métodos: Análise epidemiológica de 85 doentes com diagnóstico de espondilodiscite submetidos a tratamento cirúrgico. Foram analisados os processos clínicos, estudos de imagem e registos informáticos. Resultados: Foram tratados 51 doentes do género masculino e 34 do género feminino. A idade média foi de 48 anos (min: 6 - máx: 80). O segmento lombar foi o mais afetado e o Mycobacterium tuberculosis o agente etiológico mais frequente. A distribuição do número de casos ao longo dos anos manteve-se aproximadamente constante, com discreto aumento da incidência do Staphylococus aureus e diminuição do número de casos sem agente identificado. Trinta e nove doentes apresentavam abcesso paravertebral e 17 lesão neurológica concomitante, a maioria no segmento torácico e em relação com infeção tuberculosa. Dez doentes apresentavam imunodepressão importante. Discussão: Nesta série verificou-se um predomínio da infeção tuberculosa, no género masculino e em indivíduos jovens. Enquanto o número de casos/ano das discites tuberculosas se mantém constante, as infeções a Staphylococus aureus parecem ganhar preponderância. O abcesso paravertebral e a lesão neurológica constituíram uma complicação frequente da infeção tuberculosa. Conclusão: As infeções da coluna vertebral com necessidade cirúrgica persistem como patologia relevante. Mycobacterium tuberculosis e Staphylococcus aureus representam os principais agentes etiológicos, parecendo existir uma incidência crescente deste último agente.

  4. Trends in asthma mortality in the 0- to 4-year and 5- to 34-year age groups in Brazil.

    PubMed

    Graudenz, Gustavo Silveira; Carneiro, Dominique Piacenti; Vieira, Rodolfo de Paula

    2017-01-01

    To provide an update on trends in asthma mortality in Brazil for two age groups: 0-4 years and 5-34 years. Data on mortality from asthma, as defined in the International Classification of Diseases, were obtained for the 1980-2014 period from the Mortality Database maintained by the Information Technology Department of the Brazilian Unified Health Care System. To analyze time trends in standardized asthma mortality rates, we conducted an ecological time-series study, using regression models for the 0- to 4-year and 5- to 34-year age groups. There was a linear trend toward a decrease in asthma mortality in both age groups, whereas there was a third-order polynomial fit in the general population. Although asthma mortality showed a consistent, linear decrease in individuals ≤ 34 years of age, the rate of decline was greater in the 0- to 4-year age group. The 5- to 34-year group also showed a linear decline in mortality, and the rate of that decline increased after the year 2004, when treatment with inhaled corticosteroids became more widely available. The linear decrease in asthma mortality found in both age groups contrasts with the nonlinear trend observed in the general population of Brazil. The introduction of inhaled corticosteroid use through public policies to control asthma coincided with a significant decrease in asthma mortality rates in both subsets of individuals over 5 years of age. The causes of this decline in asthma-related mortality in younger age groups continue to constitute a matter of debate. Apresentar uma atualização das tendências da mortalidade da asma no Brasil em duas faixas etárias: 0-4 anos e 5-34 anos. Dados relativos ao período de 1980 a 2014 referentes à mortalidade da asma, conforme se definiu na Classificação Internacional de Doenças, foram extraídos Sistema de Informação sobre Mortalidade do Departamento de Tecnologia da Informação do Sistema Único de Saúde. Para analisar as tendências temporais das taxas

  5. [Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: genotype-phenotype correlation].

    PubMed

    Mendes, Catarina; Vaz Matos, Inês; Ribeiro, Luís; Oliveira, Maria João; Cardoso, Helena; Borges, Teresa

    2015-01-01

    Introdução: A hiperplasia congénita da suprarrenal por deficiência de 21-hidroxílase constitui uma das doenças hereditárias mais comuns. Resulta de diferentes mutações no gene CYP21A2 e, na maioria dos casos, a gravidade da doença correlaciona-se com a variação alélica do CYP21A2. O objetivo deste estudo foi descrever o espectro mutacional do CYP21A2 e avaliar a correlação genótipo-fenótipo numa coorte de doentes portugueses com deficiência de 21-hidroxílase. Material e Métodos: Estudo retrospetivo de 22 doentes com diagnóstico clínico de deficiência de 21-hidroxílase. Foi feita análise molecular do CYP21A2 e estabelecida a correlação genótipo-fenótipo. Resultados: Foi realizada genotipagem em 22 doentes não relacionados: 5 com a forma clássica perdedora de sal (idade média ao diagnóstico de 10,2 dias; mínimo 1, máximo 20 dias), 7 com a forma clássica virilizante simples (idade média ao diagnóstico de 3,5 anos; mínimo 0 dias, máximo 7 anos) e 10 com a forma não clássica (idade média ao diagnóstico de 5,7 anos; mínimo 4 anos, máximo 8 anos). Os defeitos genéticos mais frequentes nas formas clássicas foram o I2 splice (24%) e I172N (24%), seguindo-se o Q318X (16%) e deleções de genes (16%) e, na forma não clássica, o V281L (80%). Verificou-se uma concordância genótipo-fenótipo global de 81,8%. O genótipo permitiu prever adequadamente o fenótipo em 83,3%, 100% e 90% dos doentes com mutações compatíveis com a forma clássica perdedora de sal, clássica virilizante simples e não clássica, respectivamente. Discussão: A frequência de defeitos genéticos observados nos nossos doentes é comparável a estudos semelhantes. Observou-se, na maioria dos casos, uma boa correlação genótipo-fenótipo. Conclusões: A análise molecular do CYP21A2 fornece informação importante relativamente à gravidade da doença e no aconselhamento genético e pré-natal.

  6. Percepção Astronômica de Alunos do Ensino Médio da Rede Estadual de São Paulo

    NASA Astrophysics Data System (ADS)

    de Oliveira, E. F.; Voelzke, M. R.; Amaral, L. H.

    2005-08-01

    Embora a astronomia seja uma das ciências mais antigas da humanidade e muitos dos conceitos astronômicos serem populares, principalmente nesta época de alta globalização do conhecimento por intermédio de eficientes meios de comunicação e de obtenção da informação, notadamente através da internet, observa-se que uma parcela significativa dos estudantes encontra-se à margem dessas informações. O presente trabalho visa analisar o nível de conhecimento básico dos alunos de Ensino Médio da rede estadual da cidade de Suzano quanto aos fenômenos astronômicos que os rodeiam, tais como a sucessão dos dias e das estações do ano, além de questioná-los sobre fatos genéricos tais como: quais são os astros que se encontram mais próximos do planeta Terra, o que vem a ser o Sol, o Big Bang, um ano-luz, uma estrela cadente, a estrela de Bélem e o que ocasionou a extinção dos dinossauros. Para tanto foi elaborado um formulário constando de questões de múltipla escolha, o qual foi aplicado no primeiro colegial noturno da Escola Estadual Batista Renzi. Num espaço amostral de 34 alunos constatou-se que apenas 29,4% compreendiam a sucessão dos dias da semana, que apenas 20,6% explicaram corretamente as estações do ano, que apenas 20,6% tinham idéia de quais são os objetos celestes mais próximos da Terra, em contraposição 67,6% sabiam classificar corretamente o Sol como estrela, 55,9% relacionavam o Big Bang à origem do universo, apenas 20,6% identificavam um ano-luz como unidade de distância, 32,4% reconheciam uma estrela cadente como meteoro, 41,2% consideravam a estrela de Belém como um cometa e 50,0% explicaram corretamente a extinção dos dinossauros. A presente análise será expandida para as demais classes de primeiro colegial, não somente do período noturno, mas também do diurno da Escola Estadual Batista Renzi, bem como o formulário será devidamente ampliado. Já nesta primeira fase nota-se claramente o pequeno discernimento

  7. Bursts de raios gama

    NASA Astrophysics Data System (ADS)

    Braga, J.

    2003-02-01

    Nos últimos anos, graças principalmente aos dados obtidos pelo Compton Gamma-Ray Observatory e pelo satélite ítalo-holandês BeppoSAX, grandes avanços foram obtidos no nosso conhecimento sobre os fascinantes e enigmáticos fenômenos conhecidos por "bursts"de raios gama. Neste trabalho é feita uma revisão sobre a fenomenologia desses misteriosos objetos e são apresentados os desenvolvimentos recentes nessa área palpitante da astrofísica moderna, ressaltando tanto os resultados observacionais obtidos até o momento quanto os modelos teóricos propostos para explixá-los.

  8. [Evolution of residual risk for HIV, HCV and HBV, from 1999 to 2010, in blood donations of the Centro Hospitalar S. João, EPE, Porto, Portugal].

    PubMed

    Koch, Carmo; Araújo, Fernando

    2013-01-01

    Introdução/Objectivo: A monitorização do risco residual infeccioso pela transfusão, é importante pois permite avaliar a melhoria alcançada na segurança das dádivas de sangue e adoptar políticas adequadas de redução dos riscos. Este estudo calcula as estimativas da taxa de incidência e do risco residual infeccioso para as infecções pelo vírus da imunodeficiência humana (VIH), vírus da hepatite B (VHB) e vírus da hepatite C (VHC), entre 1999 e 2010. Os dados foram analisados em períodos de quatro anos (1999-2002, 2003-2006 e 2007-2010) e as estimativas foram comparadas com as obtidas previamente, para dádivas ocorridas entre 1991 e 1998.Material e Métodos: O estudo incluiu 209 640 colheitas de sangue, provenientes de 42 634 dadores regulares, voluntários e não remunerados. Para o cálculo do risco residual infeccioso, utilizamos o modelo matemático taxa de incidência-período de janela, descrito por Schreiber et al. Todas as dádivas foram rastreadas de acordo com a legislação portuguesa. Em Janeiro de 2001 foi implementado, em todas as dádivas de sangue, o teste de ácidos nucleicos em minipool, para o rastreio simultâneo de ácido ribonucleico (ARN) VIH-1 e VHC (Cobas Amplicor Ampliscreen-Roche©) o qual foi substituído, em Janeiro de 2007, pelo rastreio simultâneo de ácido desoxirribonucleico VHB e de ácido ribonucleico VHC e VIH-1/VIH-2, em minipool (Cobas TaqScreen MPX Test-Roche©).Resultados: O risco residual infeccioso de uma dádiva em período de janela é muito reduzido e tem diminuído ao longo dos anos. Após a implementação de teste de ácidos nucleicos em minipool para os três vírus, a probabilidade de colhermos uma dádiva infecciosa e não detectada pelos testes de rastreio foi de 1/1,67 milhões de dádivas para o vírus da imunodeficiência humana, de 1/3,33 milhões para o vírus da hepatite C e de 1/526 000 para o vírus da hepatite B.Conclusões: Durante os 12 anos em estudo verificamos uma diminuição do

  9. Giant esophageal epiphrenic diverticulum: presentation and treatment.

    PubMed

    Santos, Marcelo Protásio Dos; Akerman, Denise; Santos, Caio Pasquali Dias Dos; Santos, Paulo Vicente Dos; Radtke, Marcos Claudio; Beraldo, Fernando Bray; Gonçalves, José Eduardo

    2017-09-21

    Epiphrenic diverticulum is a rare disease associated with esophageal motor disorders that is usually asymptomatic and has a well-established surgical indication. We report a case of giant epiphrenic diverticulum in a 59-year-old symptomatic woman who was diagnosed after underwent complementary exams. Because of her symptoms, the surgical treatment was chosen, and esophageal diverticulectomy was performed along with laparoscopic cardiomyotomy and anterior partial fundoplication. RESUMO O divertículo epifrênico é uma patologia rara associada a distúrbios motores esofágicos e, frequentemente, assintomática, tendo indicações cirúrgicas bem estabelecidas. Relatamos um caso de divertículo epifrênico gigante em paciente de 59 anos, sexo feminino, sintomática, diagnosticada por exames complementares. Devido à sintomatologia, optou-se por tratamento cirúrgico, sendo realizada a diverticulectomia esofágica com cardiomiotomia e fundoplicatura parcial anterior laparoscópica.

  10. Buracos negros primordiais e astrofísica observacional

    NASA Astrophysics Data System (ADS)

    Custódio, P. S.; Horvath, J. E.

    2003-02-01

    A história da física contemporânea é pródiga em grandes descobertas (a Relatividade e a Mecânica Quântica entre as mais importantes) até meados dos anos '30. O peso destes desenvolvimentos é tão grande que outros feitos de grande porte (por exemplo, a teoria da nucleossíntese nas estrelas) são geralmente considerados como "filhotes" dos primeiros, ao menos na imaginação popular. Porém, algumas exceções à regra não-escrita são dignas de menção. Entre estas últimas está a descoberta por S.W.Hawking e colaboradores das propriedades de emissão dos buracos negros, trabalho que iniciou uma disciplina com vida própria denominada Termodinâmica de Buracos Negros.

  11. Narrative Research into the Possibilities of Classroom-Generated Stories in English Teacher Education (Una investigación narrativa en torno a las posibilidades de los relatos realizados en clase en la formación del profesorado de inglés)

    ERIC Educational Resources Information Center

    Sarasa, María Cristina

    2015-01-01

    This paper summarizes a narrative inquiry carried out with forty volunteer undergraduate participants attending the course Overall Communication, in the English Teacher Education Program in the School of Humanities of the "Universidad Nacional de Mar del Plata," Argentina. It addresses their family/academic identities and personal…

  12. "Estudia para que no te pase lo que a mi": Narrativas Culturales Sobre el Valor de la Escuela en Familias Mexicanas ("Study So That What Happened to Me Doesn't Happen to You": Cultural Narratives about the Value of Schooling in Mexican Families).

    ERIC Educational Resources Information Center

    Ramos, Claudia Saucedo

    2003-01-01

    Narratives used by parents in Mexican working-class families to motivate their children to study are examined for the advice offered and parental attitudes about the importance of school. The integration of contemporary pressures about the value of schooling is investigated, as well as the ways in which the value of schooling is being…

  13. "Estudia para que no te pase lo que a mi": Narrativas Culturales Sobre el Valor de la Escuela en Familias Mexicanas ("Study So That What Happened to Me Doesn't Happen to You": Cultural Narratives about the Value of Schooling in Mexican Families).

    ERIC Educational Resources Information Center

    Ramos, Claudia Saucedo

    2003-01-01

    Narratives used by parents in Mexican working-class families to motivate their children to study are examined for the advice offered and parental attitudes about the importance of school. The integration of contemporary pressures about the value of schooling is investigated, as well as the ways in which the value of schooling is being…

  14. Title: BVRI Photometric Study and Spectra of Algol type Pre-contact W UMa Binary, V500 Pegasi

    NASA Astrophysics Data System (ADS)

    Caton, Daniel B.; Samec, Ronald G.; Van Hamme, Walter V.; Robb, Russell M.; Clark, Jeremy; Faulkner, Danny R.

    2015-01-01

    V500 Pegasi is a NSVS and TYCHO variable, fortuitously observed by ASAS-3, 2003-2009. It is an eclipsing binary with a period of 0.57983 d. The light curves have the appearance of a detached binary. Our spectroscopy reveals that it is of F5V-type. A continuous14-year period study reveals a period increase in the orbital period at about the 1 sigma level. This is probably due to weak matter transfer to the primary component. The light curve has a large difference in primary and secondary amplitudes which is typical of detached binaries. The final solution shows a total secondary eclipse. The solution is that of a classical Algol system, but of solar type. As expected in binaries of this type, it has a large cool spot region. The secondary component has a temperature of ~4700 K (K3), which means it is somewhat over-luminous for its mass.

  15. VizieR Online Data Catalog: BVRI light curves and RV curves of 65 UMa (Zasche+, 2012)

    NASA Astrophysics Data System (ADS)

    Zasche, P.; Uhlar, R.; Slechta, M.; Wolf, M.; Harmanec, P.; Nemravova, J. A.; Korcakova, D.

    2012-04-01

    We perform a combined analysis of the light and radial velocity curves, as well as the period variation by studying the times of the minima and the interferometric orbit. A disentangling technique is used to perform the spectra decomposition. This combined approach allows us to study the long-term period changes in the system for the first time, identifying the period variation due to the motion on the visual orbit, in addition to some short-term modulation. (4 data files).

  16. A critical review of period analyses and implications for mass exchange in W UMa eclipsing binaries: Part 2

    NASA Astrophysics Data System (ADS)

    Nelson, R. H.; Terrell, D.; Milone, E. F.

    2015-12-01

    This is the second of a series of four papers, the goal of which is to identify the overcontact eclipsing binary star systems for which a solid case can be made for mass exchange. To reach this goal, it is necessary first to identify those systems for which there is a strong case for period change. We have identified 60 candidate systems; in the first paper (Nelson et al., 2014) we discussed 20 individual cases; this paper continues with the next 20. For each system, we present a detailed discussion and evaluation concerning the observational and interpretive material presented in the literature. An eclipse timing (ET) diagram (or diagrams), commonly referred to as an "O-C diagram", that includes the latest available data accompanies each discussion. In paper 4, we will discuss the mechanisms that can effect period change and which of the 60 systems can be reliably concluded to exhibit mass exchange; we will also provide a list of marginal and rejected cases suitable for future work.

  17. A critical review of period analyses and implications for mass exchange in W UMa eclipsing binaries: Paper 3

    NASA Astrophysics Data System (ADS)

    Nelson, R. H.; Terrell, D.; Milone, E. F.

    2016-02-01

    This is the third of a series of four papers, the goal of which is to identify the overcontact eclipsing binary star systems for which a solid case can be made for mass exchange. To reach this goal, it is necessary first to identify those systems for which there is a strong case for period change. We have identified 60 candidate systems; in the first two papers (Nelson et al. 2014, 2016) we discussed 40 individual cases; this paper continues with the last 20. For each system, we present a detailed discussion and evaluation concerning the observational and interpretive material presented in the literature. At least one eclipse timing (ET) diagram, commonly referred to as an "O-C diagram", that includes the latest available data, accompanies each discussion. In paper 4, we will discuss the mechanisms that can cause period change and which of the 60 systems can be reliably concluded to exhibit mass exchange; we will also provide a list of marginal and rejected cases - suitable for future work.

  18. Revidierte Lichtwechselelemente für die W UMa-Sterne V417 Aql undSS Com.

    NASA Astrophysics Data System (ADS)

    Kämper, B.-C.

    The author presents period studies for V417 Aql and SS Com, using all available material. Recently published revised period for V417 Aql (Faulkner, 1983) is confirmed and further improved. There is evidence for period changes in the past, but not exceeding 10-5 P. In the A-type system SS Com, since 1937 a marked period increase of almost 2s has taken place.

  19. STS-116 MS Fuglesang works on the UMA on the STBD side of the S0 Truss during EVA 4

    NASA Image and Video Library

    2006-12-19

    S116-E-06880 (18 Dec. 2006) --- European Space Agency (ESA) astronaut Christer Fuglesang, STS-116 mission specialist, participates in the mission's fourth session of extravehicular activity (EVA) while Space Shuttle Discovery was docked with the International Space Station. Astronaut Robert L. Curbeam Jr. (out of frame), mission specialist, worked in tandem with Fuglesang, using specially-prepared, tape-insulated tools, to guide the array wing neatly inside its blanket box during the 6-hour, 38-minute spacewalk.

  20. CCD Photometric Study of the W UMa-Type Binary II Canis Majoris in the Field of Berkeley 33

    NASA Astrophysics Data System (ADS)

    Liu, Liang; Qian, Sheng-Bang; Zhu, Li-Ying; He, Jia-Jia; Yuan, Jinzhao; Dai, Zhibin; Liao, Wenping; Zhang, Jia

    2008-06-01

    The CCD photometric data of an EW-type binary, IICMa, which is a contact star in the field of the middle-aged open cluster Berkeley33, are presented. Acomplete R light curve was obtained. In the present work, using the five CCD epochs of light minimum [three of them were calculated from Mazur etal. (1993 MNRAS, 265, 405)'s data and two from our new data], the orbital period P was revised to 0.22919704days. The complete R light curve was analyzed by using the 2003 version of W-D (Wilson-Devinney) program. It is found that this is a contact system with a mass ratio of q=0.9 and a contact factor of f=4.1%. The high mass ratio (q=0.9) and the low contact factor (f=4.1%) indicate that the system just evolved into the marginal contact stage.

  1. Angioqueratomas de fordyce múltiplos de vulva associados à cirrose hepática.

    PubMed

    Souza Teixeira, Marcelo; Dos Santos Lima, Caren; De Abreu Neves Salles1, Simone; Luz, Flávio Barbosa; Roberta Duarte Bezerra Pinto, Roberta; Pantaleão, Luciana

    2016-05-15

    Fordyce angiokeratoma is a benign skin neoplasm, characterized by erythematous-violet keratotic papules with mamillated surface, which follows a chronic and minimally symptomatic course. However, symptoms can be related such as itching, burning, bleeding, dyspareunia; aesthetic and social concerns may prompt request for treatment. The condition mainly affects men and usually occurs in the scrotum, but rarely may occur in women. A 30-year-old woman with liver cirrhosis and portal hypertension is described. Over a period of two years she developed multiple angiokeratomas of the vulva, complicated by frequent bleeding. Histopathologic analysis of the lesion confirmed the diagnosis of angiokeratoma and all lesions were surgically removed. The results of the treatment were very satisfactory, with no relapses or complications.Angioqueratoma de Fordyce é uma dermatose incomum que compõe o grupo das neoplasias cutâneas benignas, caracterizando-se pelo aparecimento de lesões papuloceratósicas, eritemato-violáceas de superfície mamilonada, que apresentam curso crônico e oligossintomático. No entanto, outros sintomas podem estar associados, como prurido, ardência, sangramento e dispareunia, além de problemas estéticos e de ordem social. Afeta principalmente homens, acometendo a região escrotal, sendo raro seu surgimento em mulheres. Relata-se caso de uma paciente com 30 anos de idade, portadora de cirrose hepática e hipertensão portal evoluindo há 2 anos com múltiplos angioqueratomas na vulva de sangramento frequente. A análise histopatológica confirmou o diagnóstico de angioqueratoma e a paciente foi submetida à exérese cirúrgica das lesões. Os resultados terapêuticos foram satisfatórios, sem recidivas ou complicações.

  2. A Visão do Universo Segundo a Concepção de um Grupo de Alunos do Ensino Médio de São Paulo

    NASA Astrophysics Data System (ADS)

    Araújo, M. A. A.; Elias, D. C. N.; Amaral, L. H.; Araújo, M. S. T.; Voelzke, M. R.

    2005-12-01

    Nesse trabalho foi identificada por meio de um questionário a visão de mundo sobre o Universo espaço e tempo entre 270 estudantes de Ensino Médio de três escolas de São Paulo. Constatou-se pouco conhecimento dos temas investigados sendo que apenas 20% dos alunos relacionaram as semanas com as fases da lua enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra e 23% tinham noções das distâncias entre objetos celestes próximos da Terra. Enquanto 56% conseguiram relacionar o Big Bang com a origem do Universo verificou-se que 37% reconheciam ano-luz como unidade de distância e 60% reconheciam o Sol como uma estrela. Apesar de 60% dos alunos indicarem a escola como principal fonte dos conhecimentos de astronomia seus conceitos ainda são inadequados havendo necessidade de aprimoramento da abordagem desses conteúdos pois apesar de popular a astronomia é veiculada de maneira pouco esclarecedora e com imprecissões.

  3. [The Impact of Electronic Monitoring on Healthcare Associated Infections: The Role of the HViTAL Platform].

    PubMed

    Oliveira, Rita Fontes; Castro, Lídia; Almeida, José Pedro; Alves, Carlos; Ferreira, António

    2016-11-01

    Introdução: Em Portugal, 9,8% dos doentes internados adquiriram infeções associadas aos cuidados de saúde, correspondendo a uma prevalência de cerca 11,7%. O Centro Hospitalar de São João desenvolveu uma plataforma de business intelligence capaz de VIgiar (os utentes), moniTorizar (o estado clínico) e ALertar (o profissional de saúde): HViTAL. Este estudo tem como objectivo avaliar o impacto da monitorização eletrónica nas infeções associadas aos cuidados de saúde desde o ano da implementação do HViTAL. Material e Métodos: Avaliaram-se os dados relativos a janeiro 2008 (data a partir da qual há registos informatizados) até dezembro de 2011, comparando-os com os dados posteriores, aqueles correspondentes a janeiro de 2012 (data de implementação do HViTAL) até 19 de outubro de 2015. Resultados: Observou-se uma tendência para o aumento dos parâmetros de infecção no período 2008 - 2011. No período correspondente a janeiro de 2012 e outubro de 2015, todos os parâmetros que constituem o indicador de infeção (previsto na contratualização) revelaram uma evolução linear negativa. Discussão: Os resultados são muito sugestivos de que o HVITAL poderá ter tido impacto na melhoria dos parâmetros associados às infeções associadas aos cuidados de saúde. Houve uma tendência crescente na aplicação de medidas básicas de controlo de infecção desde 2005, com ações de sensibilização dos profissionais de saúde, facto que, embora não analisado neste report, poderá também ter contribuído para a melhoria observada. O nosso estudo não incluiu outras variáveis tais como investimento em capital humano. Conclusão: Houve uma inequívoca melhoria em todos os domínios que caracterizam as infeções associadas aos cuidados de saúde, sugerindo um impacto positivo da introdução do HVITAL.

  4. Omental infarction: a reappraisal of conservative management in children.

    PubMed

    Estevão-Costa, José; Alvarenga, Ana Sofia; Fragoso, Ana Catarina; Garcia, Maria; Campos, Miguel

    2014-01-01

    Introdução: A melhoria da acuidade diagnóstica do enfarte do omento resultou num incremento da atitude conservadora no seu tratamento. Com o objectivo de avaliar a eficácia e segurança da abordagem não-operatória, analisámos os casos de enfarte do omento tratados num hospital terciário. Material e Métodos: Incluímos os casos de enfarte do omento primários tratados entre 2004 e 2011. Os enfartes do omento diagnosticados por imagiologia foram submetidos a tratamento conservador que constou de analgésicos e antibioterapia intravenosa. Avaliámos os dados demográficos, apresentação clínica, dados laboratoriais, imagiologia e resultado. Resultados: Ocorreram nove casos de enfarte do omento. Oito pacientes (4 rapazes), com uma idade mediana de 8,5 anos, apresentaram- se na fase inicial da doença por dor abdominal à direita; a contagem leucocitária era normal ou ligeiramente elevada. Seis casos, diagnosticados por TC após ecografia suspeita de enfarte do omento em quatro, foram trados conservadoramente sem complicações, tendo alta ao terceiro dia (mediana). Dois doentes foram apenas diagnosticados durante a intervenção cirúrgica por suposta apendicite. O nono caso apresentou-se com uma obstrução intestinal devida a hérnia interna que foi resolvida por laparoscopia. Discussão: A imagiologia foi diagnóstica na maioria dos casos de enfarte do omento, permitindo a adoção de uma abordagem conservadora. O tratamento não-operatório foi eficaz e sem complicações em todos os doentes que se apresentaram na fase inicial da doença. Um doente apresentou-se com uma complicação grave que requereu intervenção cirúrgica. Conclusão: Na ausência de um tratamento consensual para o enfarte do omento, a abordagem não-operatória é uma alternativa não invasiva e eficaz, mas requer uma vigilância clínica ativa.

  5. Experience of the MALA bag in the open abdomen management in an obstetrical intensive care unit.

    PubMed

    Malagón Reyes, Ricardo Mauricio; Reyes Mendoza, Luis Emilio; Angeles Vásquez, María de Jesús; Mendieta Zerón, Hugo

    2013-01-01

    Introdução: As indicações atuais para a gestão de abdómen aberto são a cirurgia de controlo de danos, a abordagem de sepsis intraabdominal grave, a síndrome de compartimento abdominal, o encerramento da parede abdominal sob tensão e a perda de massa da parede abdominal.Objetivo: Descrever a experiência em gestão e cirurgias de abdómen aberto usando a bolsa MALA (Maior Absorção de Líquido Abdominal).Material e Métodos: Estudo descritivo, incluindo todos os doentes com o diagnóstico de abdómen aberto gerido com a bolsa MALA internados na Unidade de Cuidados Intensivos Obstétricos de Fevereiro de 2009 a Junho de 2012.Resultados: Dos 25 casos identificados no período do estudo, sete foram eliminados por arquivos incompletos, permanecendo 18 casos para a análise. A média de idade foi de 31,5 anos. Setenta e oito por cento dos doentes eram multíparas, 50% com uma história de dois ou mais partos, 83% com uma cesariana anterior e 78% histerectomizadas, por atonia uterina, na maioria dos casos. A principal indicação para tratamento cirúrgico foi o controlo de danos. Uma doente morreu e uma segunda foi transferida para outra instituição, tendo as demais tido melhoria clínica. Doze doentes (67%) permaneceram menos de 14 dias na Unidade de Cuidados Intensivos Obstétricos e apenas uma precisou de mais de 30 dias na unidade.Conclusão: A bolsa MALA pode oferecer uma opção económica e eficaz para a gestão cirúrgica abdominal aberta, bem como umatécnica de drenagem.

  6. [Primary and secondary outcomes in oncology clinical trials: definitions and uses].

    PubMed

    Vaz-Carneiro, António; Luz, Ricardo; Borges, Margarida; Costa, João

    2014-01-01

    Introdução: A prova de eficácia de uma intervenção terapêutica em oncologia consegue-se através de ensaios clínicos rigorosamente conduzidos. Um dos factores metodológicos mais importantes é a selecção de indicadores clínicos de eficácia (outcomes), necessários ao cálculo das chamadas medidas de associação que permitem a definição de eficácia terapêutica. Material e Métodos: Foi feita uma revisão narrativa baseada em alguns dos documentos de agências reguladoras internacionais, assim como documentos de consenso entre as sociedades científicas oncológicas, procurando listar e avaliar criticamente cada um dos indicadores utilizados em ensaios clínicos oncológicos. Resultados: Identificaram-se como indicadores mais importantes a sobrevivência global, a sobrevivência livre de progressão/sobrevivência livre de doença, a toxicidade/qualidade de vida e taxa objectiva de resposta tumoral. Discussão: A selecção do outcome primário deve basear-se no conceito de eficácia terapêutica, mas também na toxicidade relativa da terapêutica experimental, na sobrevivência esperada após progressão da doença, na existência de fármacos alternativos já estudados com indicações idênticas e até a prevalência da patologia em causa. Conclusão: A selecção de indicadores em ensaios clínicos oncológicos reveste-se de especial importância e a sua selecção deve ser bem fundamentada, dependendo da doença, dos doentes e do fármaco em estudo.

  7. [Adulthood Langerhans cell histiocytosis: experience of two Portuguese hospitals].

    PubMed

    de Brito, Margarida Dantas; Martins, Éngelo; Andrade, Joaquim; Guimarães, José; Mariz, José

    2014-01-01

    IntroduçÉo: A histiocitose de células de Langerhans é uma doença heterogénea e mais frequente em crianças. Entre 1/2001 e 12/2013 admitimos 20 doentes com HCL nas duas instituições. O objectivo deste trabalho foi caracterizar esta populaçÉo, avaliando as formas de apresentaçÉo, o estadiamento e tratamento.Material e Métodos: Estudo retrospectivo; consulta do processo clínico.Resultados: Dos 16 doentes analisáveis verificamos uma mediana de idade 34 anos (15-48), 10 mulheres e 6 homens. Os motivos que determinaram a referenciaçÉo dos doentes foram: queixas respiratórias em 37,5%; alterações ósseas em 37,5%; queixas dentárias em 25%; sintomas constitucionais em 19%; lesões mucocut'neas em 6% e outro foi um achado histológico inesperado após tiroidectomia. O diagnóstico histológico foi obtido em: osso em 50%; pulmÉo em 37,5%; fígado, mucosa vulvar e peça de tiroidectomia em 6%, respectivamente. O estadiamento assumido na prática clínica foi: envolvimento de órgÉo único (uni/multifocal) em 69% e doença multissistémica em 31%. A mediana de seguimento foi cinco anos (dois meses-11 anos) e a sobrevivência global 92%. Actualmente: 19% estÉo vivos sem doença; 44% estÉo vivos com doença; 25% estÉo em tratamento e 12% morreram.DiscussÉo: Estes resultados estÉo de acordo com a literatura. No entanto, segundo as recomendações actuais consideramos que 56% doentes efectuaram estudo complementar incompleto condicionando subestadiamento e provavelmente subtratamento. Verifica-se heterogeneidade de procedimentos no estadiamento e tratamento.ConclusÉo: Frequentemente há dificuldades e atraso no diagnóstico desta entidade clínica. SÉo importantes estudos prospectivos internacionais na populaçÉo adulta.

  8. [The Importance of Early Referral in Pediatric Acute Liver Failure].

    PubMed

    Jerónimo, Mónica; Moinho, Rita; Pinto, Carla; Carvalho, Leonor; Gonçalves, Isabel; Furtado, Emanuel; Farela Neves, José

    2015-01-01

    Introdução: A falência hepática aguda é uma doença rara associada a elevada morbilidade e mortalidade apesar do aumento da sobrevida devido ao transplante hepático. Em 2008, decorreu em Portugal uma reunião sobre esta patologia em pediatria, resultando num consenso de atuação que salientou a importância da abordagem multidisciplinar e referenciação precoce para um centro de transplantação hepática. Objetivos: Caracterizar as admissões por falência hepática aguda no Serviço de Cuidados Intensivos Pediátricos do centro português com transplante hepático pediátrico. Comparar resultados antes (A) e depois de 2008 (B). Material e Métodos: Estudo observacional retrospetivo de 20 anos (1994-2014). Critérios de inclusão: idade < 18 anos e falência hepática aguda (INR ≥ 2 sem resposta à vitamina K e necrose hepatocelular). Excluíram-se as crianças com doença hepática crónica. Resultados: Incluíram-se 50 crianças com idade mediana de 24,5 meses. A causa mais comum de falência hepática aguda abaixo dos 2 anos foi metabólica (34,6%) e acima infeciosa (29,2%). Foram submetidos a transplante hepático 46%, tendo sobrevivido 78%. A mortalidade global foi 34%. A mediana do tempo de referenciação foi 7 dias no período A (n = 35) e 2 no B (n = 15; p = 0,006). A mediana do risco de mortalidade prevista pelo PRISM foi 14,7% no período A e 6,5% no B (p = 0,019). A mortalidade foi 37% vs 26% no período A e B respetivamente (p = 0,474).Discussão e Conclusões: A mortalidade global foi sobreponível à de outros centros europeus, sendo o transplante hepático a opção terapêutica mais eficaz. Após 2008 o tempo de referenciação e a gravidade dos casos na admissão reduziram, ainda sem tradução significativa na mortalidade.

  9. [Congenital Heart Disease in Children with Down Syndrome: What Has Changed in the Last Three Decades?

    PubMed

    Dias, Filipa Mestre; Cordeiro, Susana; Menezes, Isabel; Nogueira, Graça; Teixeira, Ana; Marques, Marta; Abecasis, Miguel; Anjos, Rui

    2016-10-01

    Introdução: A prevalência da síndrome de Down tem aumentado nos últimos 30 anos; 55% destas crianças apresentam cardiopatia congénita. Material e Métodos: Estudo retrospetivo longitudinal de coorte; dados clínicos obtidos em bases de dados de 1982 a 2013 com o diagnóstico de síndrome de Down ou trissomia 21 num hospital de referência em cardiologia pediátrica e cirurgia cardíaca. Objetivo: Avaliar a evolução, nas últimas três décadas, dos cuidados cardiológicos prestados às crianças com síndrome de Down ecardiopatia congénita.Resultados: Estudámos 102 doentes com síndrome de Down e cardiopatia congénita submetidos a terapêutica invasiva: cirurgiacardíaca corretiva, paliativa e cateterismo terapêutico. Em doentes referenciados no primeiro ano de vida, a referenciação foi cada vez mais precoce. O diagnóstico mais frequente foi o defeito completo do septo aurículo-ventricular (41%). Verificou-se uma tendência para cirurgia corretiva cada vez mais precoce em doentes abaixo dos 12 meses (p < 0,001). A partir de 2000, a grande maioria dos doentes foi operada antes dos seis meses de idade. As principais complicações cardíacas foram alterações de ritmo e baixo débito e as principais não cardíacas foram pulmonares e infeciosas. A taxa de mortalidade a 30 dias foi de 3/102 casos (2,9%). Dos doentes em follow-up, 89% estão em classe funcional I da NYHA. Discussão e Conclusão: A correção cirúrgica mais precoce verificada nos últimos 15 anos vai ao encontro do proposto na literatura. A taxa de mortalidade a 30 dias verificada é sobreponível aos resultados internacionais. Os doentes com síndrome de Down submetidos a cirurgia corretiva de cardiopatia congénita apresentam uma excelente capacidade funcional a longo prazo.

  10. Impact of preoperative analytical values on post-operative mortality rate of intertrochanteric fractures.

    PubMed

    Borges, Ana; Torres, João; São Simão, Ricardo; Cabral, Abel Trigo; Pinto, Rui

    2014-01-01

    Introdução: A incidência das fraturas intertrocantéricas tem aumentado ao longo dos últimos anos, bem como todos os problemas a elas associados. É importante pesquisar possíveis formas de reduzir quer co-morbilidades, quer a mortalidade pós-operatória. Decidimos avaliar o impacto de alguns valores analíticos pré-operatórios na mortalidade pós-operatória de doentes com fractura intertrocantérica, com idade igual ou superior a 65 anos.Material e Métodos: De todas as fracturas intertrocantéricas admitidas entre Janeiro de 2007 e Maio 2012, 160 doentes foram incluídos no estudo. As variáveis estudadas foram idade, género, tempo de internamento, e dados analíticos, como hemoglobina, contagem de leucócitos e plaquetas, níveis de ureia e creatinina e concentração de sódio plasmática. Informação relativa à mortalidade foi obtida através do registo civil e, considerando um ponto de corte de seis meses após a cirurgia, os doentes foram divididos em dois grupos de acordo com a sua sobrevida. Os testes de Mann-Whitney e Chi-quadrado foram utilizados para estudar a associação entre as nossas variáveis e a sobrevida dos doentes.Resultados: A nossa população apresentava uma idade mediana de 82 anos de idade e uma maioria de mulheres (79,4%). Nos primeiros 6 meses após a cirurgia, 27 doentes dos iniciais 160 (16,1%) faleceram. A mortalidade estava relacionada com valores baixos de hemoglobina, elevados de plaquetas, elevados de creatinina e baixa concentração de sódio plasmático.Conclusão: A taxa de mortalidade pos-operatória da cirurgia da anca é elevada. Os nossos resultados podem ser utilizados parareduzir esta taxa, corrigindo valores analíticos pré-operatórios.

  11. Contribuições para o projeto da câmara infravermelha Spartan do telescópio SOAR

    NASA Astrophysics Data System (ADS)

    Laporte, R.; Jablonski, F.; Loh, E.

    2003-08-01

    Como parte de uma colaboração entre a Divisão de Astrofísica do INPE, IAG-USP, Instituto do Milênio MEGALIT e a Michigan State University, trabalhamos durante um ano junto ao grupo do Dr. Edwin Loh (MSU) no projeto e detalhamento de diversos subsistemas para a câmara infravermelho Spartan do telescópio SOAR. Trata-se de um imageador para as bandas J, H e K que explora todo o potencial, em termos de qualidade de imagem e campo de visada, fornecido pelo sistema de óptica adaptativa de primeira ordem do telescópio SOAR. Projetamos soluções detalhadas para os subsistemas de rodas de filtros/grismas/máscaras de Lyot; subsistema de compactação do mosaico de detectores em duas versões distintas; subsistema de alimentação de Nitrogênio líquido. Mantivemos sempre uma supervisão geral sobre todas as partes restantes e os respectivos envelopes volumétricos produzindo soluções para a integração de todos os componentes. Neste trabalho, ilustramos as principais contribuições e fornecemos um resumo do estado atual do instrumento.

  12. Telescópio de pequeno porte como suporte ao ensino em cidades com intensa poluição luminosa II

    NASA Astrophysics Data System (ADS)

    Pereira, P. C. R.; Santos-Júnior, J. M.; Cruz, W. S.

    2003-08-01

    Para a maioria dos estudantes, sua passagem pelo ensino formal fundamental envolve a transmissão de fatos que devem ser guardados para um exame, a habilidade para lembrar fórmulas e, eventualmente, a repetição de experimentos que devem produzir resultados exigidos pelo professor. O resultado deste modelo de ensino, ao longo dos anos, é conhecido por todos: desconhecimento e descontentamento, por parte dos estudantes, de temas relativos ao papel e aos processos da ciência. Acreditamos que a Astronomia, pelo seu caráter observacional, é uma das áreas do conhecimento que pode contribuir neste cenário. A Fundação Planetário da Cidade do Rio de Janeiro possui um telescópio Meade LX-200 (25cm) que, juntamente com as câmeras CCD ST-7E e ST8E, tem sido utilizado em projetos voltados aos estudantes do ensino médio desde o ano 2000. Tais projetos envolvem a condução de um projeto de pesquisa observacional num nível apropriado, e possibilitam o contato com técnicas e novas tecnologias: computador, software para manipulação de dados e gráficos, programas de tratamento e redução de dados, uso de equipamentos óptico-eletrônicos (telescópio e CCD), bem como o processo de aquisição de conhecimento. Dentro da proposta dos anos anteriores, priorizamos projetos de uma noite, ou seja, procuramos trabalhar com fenômenos que apresentem variabilidade com intervalo de recorrência relativamente curto. Em todos os casos, optamos pela fotometria diferencial, que tem se mostrado bastante eficiente para o céu luminoso como o da cidade do Rio de Janeiro. Neste painel, apresentamos alguns dos projetos desenvolvidos no último ano, com 25 estudantes. Apresentamos os resultados da observação da variável pulsante AI Vel (V = 6,6) e da variável cataclísmica FO Aqr (V = 13,5), e do monitoramento do trânsito da lua de Júpiter, Europa, ocorrido em 30 de abril de 2003. As curvas de luz produzidas para as primeiras estão concordantes com as da literatura, assim

  13. [Allergic contact dermatitis to metals over a 20-year period in the Centre of Portugal: evaluation of the effects of the European directives].

    PubMed

    Teixeira, Vera; Coutinho, Inês; Gonçalo, Margarida

    2014-01-01

    Introdução: Os metais são causa frequente de dermatite de contacto alérgica. Desde a introdução da Directiva Comunitária do Níquel (1994/27/CE; 2004/96/CE) e, mais recentemente, da Directiva do Cimento (2003/53/CE), nos países nórdicos tem havido uma diminuição da sensibilização aos metais. A aplicabilidade destas medidas e o seu impacto permanece por avaliar em Portugal. Material e Métodos: Foi realizado um estudo retrospectivo (1992-2011) na Consulta de Alergologia Cutânea com o principal objectivo de analisar a variação dos padrões de sensibilização aos metais (níquel [Ni], cobalto [Co] e crómio [Cr]) ao longo de 20 anos, em particular no que se refere ao género, grupo etário e relação com a actividade profissional. Resultados: Do total de 5 250 doentes estudados, em 1 626 (31%) observámos pelo menos um teste epicutâneo positivo a um metal (26,5% ao Ni; 10,0% ao Co e 7,0% ao Cr). A prevalência de sensibilização ao Ni era significativamente maior nas mulheres (34,4% versus 8,9%) e ao Cr nos homens (11,5% versus 5,0%). Não houve diminuição significativa da sensibilização ao Ni ao longo dos 20 anos, mas o contributo da faixa etária dos 16-30 anos no total de mulheres sensíveis a este metal decresceu de forma significativamente estatística ao longo dos anos (p < 0,001). A sensibilização ao Cr decresceu sobretudo nos homens (r = -0,535), muito particularmente nos casos relacionados com a construção civil (r = -0,639), enquanto a reatividade ao Cr relacionado com o uso de calçado se manteve estável. Discussão: A manutenção dos elevados níveis de sensibilização ao níquel denota ainda uma fraca implementação das Directivas comunitárias mas a redução da percentagem de mulheres jovens poderá significar já algum efeito positivo nesta faixa etária. Ao contrário, a Directiva referente à redução do Cr no cimento parece estar a ter os seus efeitos positivos. Há, contudo, necessidade de interferir com o conte

  14. [HIV infection and non-AIDS-defining malignancies: an outpatient clinic experience].

    PubMed

    Fevereiro, Maria do Carmo

    2014-01-01

    Introdução: Os doentes infectados pelo Vírus da Imunodeficiência Humana têm um risco elevado de desenvolver diferentes tipos de Neoplasias. Com a introdução da terapêutica anti-retroviral de alta potência, e consequente aumento da sobrevida, assistimos a uma mudança do espectro das patologias relacionadas com a infecção, nomeadamente das doenças Oncológicas, com aumento das Neoplasias Não Definidoras em deterimento das Definidoras de SIDA.Material e Métodos: Caracterização dos doentes com infecção Vírus da Imunodeficiência Humana e diagnóstico de Neoplasias Não Definidoras acompanhados ao longo de 16 anos na Consulta de Medicina/Imunodeficiência do Hospital de São José, através da consulta dos processos clínicos e avaliação retrospectiva dos aspectos demográficos, epidemiológicos, clínico-laboratoriais, tratamento e sobrevida.Resultados: Nos 1 042 doentes avaliados, foram identificados 34 casos de Neoplasias Não Definidoras, principalmente em homens (78%) e com idade mediana de 55 anos. As neoplasias mais frequentes foram: pulmão (20,6%), bexiga (17,6%), próstata (8,8%) e canal anal (5,9%), sendo o tempo médio entre o diagnóstico da infecção pelo Vírus da Imunodeficiência Humana e da Neoplasias Não Definidoras de 6,8 ± 4 anos. Na altura do diagnóstico da Neoplasias Não Definidoras a maioria dos doentes (78,8%) estava sob terapêutica anti-retroviral de alta potência, em média desde há 5,7 ± 3 anos, encontrando-se imunovirologicamente controlada. No total verificaram-se 45,5% óbitos, sobretudo em doentes com Neoplasia do pulmão (20%).Conclusão: Perante o risco de desenvolvimento de Neoplasias Não Definidoras nos doentes infectados pelo Vírus da Imunodeficiência Humana, torna-se fundamental o investimento em estratégias de prevenção, promoção de cessação tabágica e vacinação, bem como aplicação de protocolos de rastreio ajustados a esta população.

  15. [Hypofractionation in locally advanced breast cancer: "flash" scheme].

    PubMed

    Padilha, Marisa; Gonçalves, Sara; Fardilha, Carlos; Melo, Gilberto; Miranda, Cristina; Alves, Paula

    2013-01-01

    Introdução: O carcinoma da mama é uma das principais causas de morte no nosso país. No Serviço de Radioterapia do Instituto Português de Oncologia de Coimbra de Coimbra utilizamos, desde há mais de 30 anos, um esquema de hipofraccionamento de radioterapia, denominado “Flash”, como opção terapêutica em doentes idosos ou com baixo Performance Status, portadores de carcinoma da mama localmente avançado ou com estádios IIb ou IV, com intenção neoadjuvante ou paliativa. Objectivos: Avaliar a resposta ao tratamento, nomeadamente sobrevivência global aos três anos, resposta local e toxicidades aguda e crónica, no grupo de doentes seleccionados submetidos a esquema de hipofraccionamento, em estudo retrospectivo. Metodologia: Entre Janeiro de 2006 e Dezembro de 2008, um total de 83 doentes com diagnóstico de Carcinoma da Mama Localmente Avançado ou com estádios IIb ou IV, foi submetido a “Flash” mamário. A dose de radioterapia prescrita foi de 13Gy / 2Fr / 3 dias (em 23 doentes - 27,7%) e 26Gy / 4Fr / 2,5 semanas (em 60 doentes - 72,3%), com fotões de 4 MV, sobre a mama afectada. Foi avaliada sobrevivência global segundo o método de Kaplan-Meier. A análise estatística foi efectuada através da aplicação SPSS, versão 17.0 e os testes estatísticos foram avaliados ao nível de significância de 5%. Resultados: 80 doentes (96,4%) que efectuaram “Flash” mamário eram do género feminino, com idades compreendidas entre os 59 e os 93 anos (idade média 80,72 + 5,87 anos) e Performance Status (Karnosfsky: 0 - 100) entre 90 e 50%. Em 72 doentes (86,7%) o diagnóstico histológico foi Carcinoma Ductal Invasivo. A cirurgia após a realização do “Flash” Mamário foi realizada em 44 doentes (53%) após evidência de resposta local à radioterapia, sendo a Mastectomia Radical Modificada a técnica cirúrgica mais frequente. Efectuou-se o diagnóstico de metastização óssea em 10 doentes (12%), sendo que a taxa de sobrevivência global foi

  16. Comparative study between kidney transplantation with deceased donor expanded criteria and donor standard criteria in a single center in Brazil.

    PubMed

    Mota, Luana Soriano; Oliveira, Claudia Maria Costa de; Pinheiro, Francisco Martho Leal; Santos, Larissa Costa de Oliveira; Nóbrega, Danilo Gonçalves; Fernandes, Paula Fbc; Costa, Alda Angélica de Melo; Silva, Sônia Leite da

    2016-01-01

    ção retardada do enxerto - DGF - (62,9% no DCP vs. 70,8% no DCE; p = 0,44) nos dois grupos. Os transplantes com DCE apresentaram uma taxa de filtração glomerular (TFG) significativamente inferior aos 12 meses (56,8 ± 26,9 vs. 76,9 ± 23,7; p = 0,001). A sobrevida dos pacientes em 1 ano foi significativamente inferior no grupo de DCE, mas não houve diferença na sobrevida dos enxertos após exclusão de perdas por óbito com rim funcionante. O grupo com DCE associou-se com níveis significativamente mais baixos de TFG ao longo do primeiro ano de transplante, bem como uma menor sobrevida dos pacientes em 1 ano, quando comparado ao grupo com doador padrão.

  17. Ondas de choque em jatos de quasares e objetos BL Lacertae

    NASA Astrophysics Data System (ADS)

    Melo, F. E.; Botti, L. C. L.

    2003-08-01

    Este trabalho é parte de um projeto que vem sendo realizado há dois anos no CRAAM, cujos objetivos principais são analisar e aplicar um modelo generalizado de ondas de choque em jatos relativísticos de plasma, presentes em quasares e objetos BL Lacertae, para explicar a variabilidade observada nestes objetos. O método consiste em uma decomposição de curvas de luz em séries de explosões similares, em várias freqüências, baseando-se em uma evolução espectro-temporal média das explosões. A partir da evolução média, um ajuste de cada explosão é feito com base em equações empíricas, modificando-se apenas parâmetros específicos de cada explosão. Inicialmente o modelo foi aplicado ajustando-se as curvas de luz a explosões delineadas por uma evolução do choque em três estágios, segundo a predominância do processo de emissão: síncrotron, Compton e adiabático. Entretanto, nesta nova fase de projeto, visando uma parametrização mais concisa, uma otimização do algoritmo de ajuste e uma convergência mais rápida, a formulação para cada evento foi assumida com uma evolução em apenas dois estágios: subida e descida. Isto possibilitou uma ótima delineação das curvas de luz das fontes OV236, OJ287, 3C273 e BL Lac, entre 1980 e 2000, nas freqüências 4.8, 8.0, 14.5 e 22 GHz, utilizando-se dados do Observatório da Universidade de Michigan, do Observatório do Itapetinga (Atibaia SP) e do Observatório Metsähovi. Como conclusões importantes, verificou-se que: os parâmetros ajustados descrevem o comportamento do jato; os valores do índice que descreve a expansão do jato sugerem que o mesmo se expande de uma forma não-cônica; o campo magnético é turbulento atrás da frente de choque; e as peculiaridades das explosões são devidas à influência de grandezas tais como o coeficiente da distribuição espectral de energia dos elétrons, a intensidade de campo magnético e o fator de feixe Doppler, no início do choque.

  18. Health Policy on the pages of Revista de Saúde Pública.

    PubMed

    Bousquat, Aylene; Tanaka, Oswaldo Yoshimi

    2016-11-10

    We carried out a narrative review of the scientific production in the area of Policy, Planning and Management in Revista de Saúde Pública (RSP), between 1967 and 2015. All the fascicles of RSP, in the period, were accessed via SciELO platform, which provides all articles online. We selected and classified the articles according to the main topics of scientific production in the area of Policy, Planning and Management. Revista de Saúde Pública has published 343 articles on this subject, with significant growth in the last two decades. The most discussed topics were Health Economics, Primary Health-care, Access and Use of Health Services, and Evaluation of Services and Programs. In the last decade, the topics of Policy and Access to Medicines and Public-Private Relationship, including judicialization, gained importance. The pages of RSP embraced the vast and diverse production of Policy, Planning and Management in its first 50 years, contributing to the consolidation of the area in Brazil. RESUMO Foi realizada revisão narrativa da produção científica do campo de Política, Planejamento e Gestão veiculada na Revista de Saúde Pública (RSP), entre 1967 e 2015. Todos os fascículos da RSP, no período, foram acessados via plataforma SciELO, que disponibiliza todos os artigos online. Foram selecionados e classificados os artigos segundo os principais temas da produção científica da área de Política, Planejamento e Gestão. Foram publicados 343 artigos, com crescimento expressivo nas últimas duas décadas. Economia da Saúde, Atenção Primária à Saúde, Acesso e Utilização de Serviços de Saúde e Avaliação de Serviços e Programas foram os temas mais abordados. Na última década, os temas Política e Acesso a Medicamentos e Relação Público-Privado, incluindo a judicialização, ganharam importância. As páginas da RSP abrigaram vasta e diversa produção de Política, Planejamento e Gestão nos seus primeiros 50 anos, contribuindo para

  19. Mumps Outbreak among Highly Vaccinated Teenagers and Children in the Central Region of Portugal, 2012-2013.

    PubMed

    Cordeiro, Eugénio; Ferreira, Muriel; Rodrigues, Fernanda; Palminha, Paula; Vinagre, Elsa; Pimentel, João Pedro

    2015-01-01

    Introdução: A vacina contra o sarampo, parotidite epidémica e rubéola foi introduzida no Programa Nacional de Vacinação em 1987, atingindo rapidamente uma cobertura vacinal > 92% para duas doses, com redução importante da incidência anual da doença. Reportamos um surto de parotidite na Região Centro de Portugal ocorrido entre outubro de 2012 e março de 2013. Material e Métodos: Foram investigados os casos de tumefação de glândulas salivares e sintomas compatíveis com parotidite. Para cada caso foram analisados dados demográficos, clínicos, laboratoriais e vacinais. Resultados: Ao longo de seis meses foram notificados 148 casos: 87,8% ocorreram em três dos 16 concelhos afetados e 78,4% tinham uma relação epidemiológica conhecida. A idade mediana foi de 14,5 anos (2-62) e 70,3% tinham entre 11 e 20 anos; 61,5% eram do sexo masculino. Na maioria dos casos a doença foi ligeira, com uma duração média de sete dias (2-20). A febre ocorreu em 80,4% e a glândula parótida apresentou envolvimento unilateral em 55,4%; sete casos tiveram orquite, um ooforite e uma nefrite. Dois doentes foram internados. A transmissão da doença ocorreu predominantemente em ambiente escolar, com taxas de ataque < 30%. A maioria dos casos ocorreu em indivíduos vacinados (92%), dos quais 86,8% com duas doses. Em 17,7% foi identificada uma dosede vacina contendo a estirpe Rubini. Foi identificado o genótipo G do vírus da parotidite em quatro casos. Discussão: Este surto de parotidite numa população com coberturas vacinais elevadas, atingindo principalmente adolescentes em meio escolar, poderá dever-se à efetividade parcial da vacina contra a doença (especialmente no grupo vacinado com a estirpe Rubini), à perda de imunidade ao longo do tempo ou ainda à discordância entre os genótipos vacinal e circulante causador de doença. Conclusões: O relato deste surto releva a importância da discussão sobre a necessidade de mais doses de reforço da vacina atual

  20. A atuação do Observatório Nacional registrada nos relatórios ministeriais 1889 a 1930

    NASA Astrophysics Data System (ADS)

    Rodrigues, T.

    2003-08-01

    O período republicano até 1930 foi marcante na história do Observatório Nacional. Diversas reformas levaram a instituição a três ministérios diferentes e mudaram a ênfase do seu trabalho. A tão aguardada mudança para uma nova sede, em São Cristóvão, em 1920, não foi suficiente para que a instituição acompanhasse o ritmo tomado pela astronomia no mundo e se firmasse como ambiente de pesquisa. Uma análise simplificada poderia caracterizar um período de produção científica insignificante, dado o distanciamento da instituição dos novos rumos da astrofísica e da rápida inovação dos instrumentos, além do pequeno volume de publicações. Era uma época em que ainda não existiam os mecanismos formais de apoio e avaliação da atividade científica. Esse trabalho procura identificar a real atividade do Observatório no conteúdo dos Relatórios Ministeriais que, ao final de cada ano, apresentava as atividades, sucessos e problemas enfrentados pela instituição. Questões como instrumental e recursos humanos necessários; entraves burocráticos e financeiros; e articulações com outros observatórios se complementaram entre si ao longo desses anos para definir o perfil institucional e alguns aspectos fundamentais para a construção da astronomia no país. É possível concluir que a ênfase em serviços geográficos e de meteorologia, ao lado da inadequação dos instrumentos e do local, quase fizeram desaparecer a pesquisa em astronomia. Porém, vale destacar a sobrevivência de alguns trabalhos, como, por exemplo, variação de latitude e observação de estrelas duplas que mantiveram importante intercâmbio com outros grupos de pesquisa, demonstrando o constante esforço dos astrônomos e das diretorias em defesa da atividade científica.

  1. Hyperbaric Oxygen Therapy for the Treatment of Fournier's Gangrene: A Review of 34 Cases.

    PubMed

    Rosa, Isabel; Guerreiro, Francisco

    2015-01-01

    Introdução: A gangrena de Fournier é uma infecção necrotizante grave, que pode levar à morte se não for tratada rapidamente. O tratamento baseia-se na combinação do desbridamento cirúrgico, antibioterapia e terapêutica de suporte. A oxigenoterapia hiperbárica surge como adjuvante quer na optimização da oxigenação dos tecidos infetados, quer através da ação bactericida e bacteriostática. Material e Métodos: Foi feita uma revisão dos processos clínicos dos doentes com gangrena de Fournier referenciados ao Centro de Medicina Subaquática e Hiperbárica da Marinha para realizar oxigenoterapia hiperbárica num período de 25 anos. Resultados: Foram tratados 34 doentes. A maioria dos doentes era do género masculino (94,1%) com idade média de 53,7 anos. A diabetes foi a comorbilidade mais frequentemente associada. O foco de infeção mais frequente foi o trato urinário. A taxa de mortalidade foi de 20,8%. Discussão: A diabetes é a comorbilidade mais frequente, sugerindo a diabetes como factor predisponente. A maioria dos doentes falecidos tinham diabetes, todavia não se conseguiu estabelecer correlação entre diabetes e morte. A área de residência dos doentes parece limitar a referenciação ao centro. Conclusões: A gangrena de Fournier, apesar de rara, é uma doença potencialmente fatal, nomeadamente em doentes com comorbilidades como a diabetes. A oxigenoterapia hiperbárica está recomendada como adjuvante à terapêutica convencional e, quando este recurso está disponível, deve ser considerado. São necessários mais estudos para melhor aferir o papel da oxigenoterapia hiperbárica no tratamento desta entidade.

  2. Symptoms and reason for a medical visit in lung cancer patients.

    PubMed

    Gonzalez-Barcala, Francisco Javier; Falagan, José Antonio; Garcia-Prim, Jose Maria; Valdes, Luis; Carreira, Jose Martin; Pose, Antonio; Canive, Juan Carlos; Anton, Diana; Garcia-Sanz, Maria Teresa; Puga, Amalia; Temes, Enrique; Lopez-Lopes, Rafael

    2014-01-01

    Contexto: A Os doentes com o diagnóstico de cancro do pulmão estão habitualmente sintomáticos no momento do diagnóstico, sendo comum que o médico ou o doente não associem essa sintomatologia com a eventualidade de um tumor maligno. Objectivos: Este estudo teve como objectivo a análise dos sintomas de doentes com cancro do pulmão e sua relação com as características pessoais ou com a doença oncológica. Material e Métodos: Foi levado a cabo um estudo retrospectivo englobando todos os doentes com o diagnóstico de cancro do pulmão na Região de Saúde de Pontevedra (Espanha) ao longo de um período de três anos. São analisados os sintomas de apresentação do doente, o motivo de consulta e a concordância entre ambos ou com quaisquer factores correlacionados. Resultados: Foram incluídos no estudo 358 doentes, com uma média etária de 68,7 anos, sendo 87% dos doentes do sexo masculino. Os sintomas iniciais mais comuns foram sintomas constitucionais em 30,4% dos casos, tosse em 20,9% e dor torácica, descrita por 12% dos doentes. O motivo de consulta mais frequente foi dispneia em 22,1% dos doentes, um achado acidental em 15,4% dos doentes e hemoptise em 12,8%. Observou-se uma associação moderada (coeficiente de correlação = 0,495) entre os sintomas iniciais e o motivo de consulta. Conclusões: Uma elevada percentagem de doentes com um diagnóstico de cancro do pulmão apresentou sintomas associados com o tumor no momento do diagnóstico, mesmo num estadio inicial da doença.

  3. Clinical, genetic and neuropathological features of frontotemporal dementia: an update and guide.

    PubMed

    Pelicano Paulos, Jorge; Massano, João

    2013-01-01

    Introdução: A Degenerescência Lobar Frontotemporal engloba um conjunto de situações heterogéneas que partilham sintomas cognitivos e comportamentais, bem como características patológicas macroscópicas. As bases genéticas e características histopatológicas são bastante diversas e formam a base da classificação molecular das várias doenças, sendo difícil fazer uma correlação com os achados clínicos e síndromas. A investigação científica trouxe um conjunto vasto de conhecimentos, nem sempre fáceis de acompanhar,especialmente nos últimos anos em relação à genética e histopatologia.Material e Métodos: Os autores fizeram uma pesquisa de literatura neste tema, escolheram referências relevantes, extraíram e sistematizaram os dados.Resultados e Conclusão: o texto apresenta uma revisão atualizada dos aspetos clínicos, genéticos e histopatológicos da Degenerescência Lobar Frontotemporal, com ênfase especial na Demência Frontotemporal, a doença mais comum. O tratamento é também revisto e são propostas pelos autores estratégias relativamente à escolha dos testes genéticos na prática clínica. Deveriam serpromovidos a atenção e conhecimento públicos sobre este grupo de doenças.

  4. Situação da Mulher na Astronomia Brasileira

    NASA Astrophysics Data System (ADS)

    Silva, Adriana V. R.

    2007-07-01

    O conteúdo desse texto surgiu de uma apresentação de mesmo título que fiz na XXXI Reunião Anual da Sociedade Astronômica Brasileira (SAB) em 2005. Esse tema foi inspirado originalmente pela minha participação no "2nd UIPAP International Conference on Women in Physics" realizado entre 23 e 25 de maio de 2005 no Rio de Janeiro. Essa é uma conferência internacional que acontece de três em três anos, sendo que a primeira ocorreu em 2002 na cidade de Paris, França. Participei dessa conferência como membro da delegação da Sociedade Brasileira de Física e um dos trabalhos que apresentei versava sobre a situação das mulheres na Astronomia brasileira, cujos resultados principais discorro a seguir. A situação das astrônomas, baseada nos dados dos sócios da SAB coletados no final de 2004, é comparada com a das físicas brasileiras e também com as nossas colegas americanas. Os dados identificam ainda uma maior evasão da carreira por parte das mulheres do que os homens. Alguns dos possíveis motivos da evasão são discutidos, como o desejo de constituir família e/ou isolamento. Resultados um tanto preocupantes com relação à distribuição de bolsas de produtividade do CNPq também são apresentados. As principais discussões e estratégias recomendadas nesse congresso são mencionadas de forma resumida ao final.

  5. Hypertriglyceridemia: Is there a role for prophylactic apheresis? A case report.

    PubMed

    Francisco, Ana Rita; Gonçalves, Inês; Veiga, Fátima; Pedro, Mónica Mendes; Pinto, Fausto J; Brito, Dulce

    2016-01-01

    Severe hypertriglyceridemia has been consistently associated with an increased risk of cardiovascular disease and other complications, namely acute pancreatitis. We report a case of a 64 year-old woman with hypertrophic cardiomyopathy and metabolic syndrome with triglyceride level of 3260 mg/dL. Plasma exchange was performed with simultaneous medical treatment to achieve a rapid and effective lowering of triglycerides in order to prevent clinical complications. After three plasmapheresis sessions a marked reduction in triglyceride and total cholesterol levels was observed. Several cases have shown the importance of plasmapheresis in the treatment of acute pancreatitis. We intend to demonstrate the applicability of this technique as primary prophylaxis in the presence of extremely high serum triglyceridemia levels. Resumo A hipertrigliceridemia grave tem sido associada de forma consistente ao aumento do risco cardiovascular e a outras complicações, nomeadamente, pancreatite aguda. Descrevemos um caso de uma mulher de 64 anos, com miocardiopatia hipertrófica e síndrome metabólica com valor sérico de triglicerídeos de 3260 mg/dL. Foi efectuada plasmaferese e optimizado o tratamento médico para alcançar uma redução rápida e efectiva dos níveis dos triglicerídeos, prevenindo complicações clínicas. Após três sessões de plasmaferese, verificou-se uma redução marcada dos triglicerídeos e do colesterol total. Existem alguns casos descritos na literatura demonstrado a importância da plasmaferese no tratamento da pancreatite aguda em contexto de hipertrigliceridemia grave. Os autores pretendem com este caso demonstrar a aplicabilidade desta técnica em contexto de prevenção primária em doentes com níveis de triglicerídeos extremamente aumentados.

  6. Análise da cinemática interna das regiões HII gigantes e das galáxias HII

    NASA Astrophysics Data System (ADS)

    Plana, H.; Telles, E.; Maíz-Apellániz, J.

    2003-08-01

    Neste trabalho nós mostramos os primeiros resultados de um estudo sobre a cinemática das Regiões HII Gigantes (GHIIRs) em galáxias próximas. Essas regiões HII têm um diâmetro médio entre 100 pc e 1000 pc e uma taxa de formação estelar de 106 M¤ / ano sendo equivalente à observada em galáxias de tipo tardio correspondendo a uma taxa de formação estelar por unidade de volume uma ordem de magnitude maior que a observada em regiões HII normais. Usando espectros de fenda longas em várias posições, nós construímos mapas de velocidades, de dispersão e de intensidade para várias linhas de emissão como Ha, Hb, [NII]6584 Å, [OIII]5007 Å e o doublet de [SII], para cinco regiões gigantes: NGC 2403 II e IV, NGC 595, NGC 5461, NGC 5471, NGC 5455. O estudo da cinemática (mapas de velocidades e da dispersão) mostrou, por exemplo, a presença de cascas em expansão em NGC 595 ou perfis de emissão com várias componentes em NGC 5461. Os perfis de emissão também mostram velocidades supersônicas. Os resultados são discutidos em comparação com os de estudos anteriores realizados.

  7. Surgical correction of ectopic penis and scrotum associated with bilateral orchidopexy.

    PubMed

    Sobral, Daniel Santos Rocha; Silva, Helder Damásio da; Damázio, Eulálio

    2017-01-01

    Ectopic penis is usually associated with penoscrotal transposition, and it is rarely observed in isolation. We report a surgical approach for an extremely rare case. A 10-year-old male patient with bilateral cryptorchidism and ectopic penis and scrotum in perineal area, with no penoscrotal transposition, representing an association not yet described in literature. A previous orchiopexy failed due to ectopic scrotum. By means of an inverted Y incision, the penis was mobilized and a perineal skin flap in form of a testicular sac was prepared. Finally orchiopexy was performed. The surgery was essential to treat cryptorchidism and to improve the self-image of the patient. RESUMO O pênis ectópico geralmente ocorre associado à transposição peno-escrotal, sendo raro isoladamente. Relatamos uma abordagem cirúrgica para um caso extremamente raro. Tratava-se de paciente do sexo masculino, 10 anos, com criptorquidia bilateral e pênis e escroto ectópicos, na região perineal, sem transposição peno-escrotal, representando uma associação ainda não descrita na literatura. Orquidopexia prévia sem sucesso, devido à ectopia do escroto. Por meio de uma incisão em Y invertido, mobilizou-se o pênis e preparou-se um retalho da pele perineal em forma de bolsa testicular. Por fim, realizou-se a orquidopexia. A cirurgia foi fundamental para tratar a criptorquidia e promover ganho na autoimagem do paciente.

  8. Implementação de um algoritmo para a limpeza de mapas da RCFM

    NASA Astrophysics Data System (ADS)

    Souza, C. L.; Wuensche, C. A.

    2003-08-01

    A Radiação Cósmica de Fundo em Microondas (RCFM), descoberta por Penzias e Wilson em 1965, é uma das ferramentas mais poderosas para o estudo da cosmologia. Com a descoberta de flutuações de temperatura na RCFM, da ordem de uma parte em 105, pelo COBE (1992), uma nova era teve início. Nos últimos onze anos, diversos instrumentos fizeram novas medidas de alta precisão, refinando os resultados apresentados pelo COBE, culminando com os resultados recentes do satélite WMAP. A análise de dados da RCFM, especialmente no caso de experimentos com pequena cobertura do céu, apresenta uma série de dificuldades devido a emissões de contaminantes externos, tais como a emissão da Galáxia e de fontes pontuais, e de ruídos intrínsecos tanto ao sistema de detecção quanto à estratégia de observação do céu. Uma das soluções típicas para a filtragem de dados brutos de um experimento para medir flutuações de temperatura é aplicar um gabarito (template) e um filtro passa alta ao produzir mapas simplificados (sem considerar matrizes de correlação ou covariância). No caso de experimentos que utilizam detectores HEMT, essa combinação de filtros remove, satisfatoriamente, ruídos do tipo 1/f gerados pela instabilidade no ganho do detector acoplado ao movimento do instrumento, definido pela estratégia de observação. Entretanto, o sinal resultante medido, tanto em simulações quanto em séries temporais reais, sugere que parte do sinal cosmológico pode estar sendo removido junto com o ruído dos detectores. Este trabalho descreve as etapas para a produção de um mapa típico (simulado) e os testes preliminares de um algoritmo para remover ruídos do tipo 1/f introduzidos pela estratégia de observação sem prejudicar a qualidade do sinal cosmológico presente no mapa.

  9. Toxic epidermal necrolysis: the experience of Coimbra's burn unit.

    PubMed

    Pinheiro, Susana; Carvalho, Ricardo; Ramos, Sara; Diogo, Carla; Caetano, Marisa; Cabral, Luís; Cruzeiro, Celso

    2013-01-01

    Introdução: A necrólise epidérmica tóxica é uma doença sistémica grave, potencialmente fatal, caracterizada por febre, descolamento dermoepidérmico extenso e erosão das mucosas. Em 95% dos casos, consiste numa reacção idiossincrática à administração de fármacos. A gravidade da doença é estratificada através da aplicação de uma escala de previsão da mortalidade, denominada SCORTEN. O tratamento obriga à suspensão imediata do fármaco suspeito e à referenciação do doente a uma Unidade de Queimados capaz de assegurar um tratamento específico.Material e Métodos: Estudo retrospectivo de 21 doentes internados com SJS/ Necrólise Epidérmica Tóxica na Unidade de Queimados dos Hospitais da Universidade de Coimbra, entre Janeiro de 1999 e Dezembro de 2010 com avaliação dos resultados e das opções terapêuticas. Comparação das taxas de mortalidade desses doentes com as previstas pelo SCORTEN, no sentido de avaliar a capacidade preditiva desta escala. Os dados foram analisados no programa SPSS 17.0®.Resultados: Foram internados 13 doentes do sexo feminino (61,9%) e 8 do sexo masculino (38,1%), com média de idades de 55,6 ± 23,7 anos e com 51% ± 22,4% de superfície corporal atingida. A taxa de mortalidade dos doentes internados foi de 47,6% e a prevista pelo SCORTEN foi de 42,2%. %. O tratamento instituído centrou-se na remoção imediata do fármaco suspeito e na referenciação precoce do doente para a unidade.Conclusão: A fisiopatologia da necrólise epidérmica tóxica não está completamente esclarecida, pelo que não existe actualmente uma terapêutica específica, comprovadamente eficaz. A utilização do SCORTEN permite uma previsão adequada da taxa de mortalidade nestes doentes.

  10. [Metallosis: A Rare Cause of Autoimmune Hemolytic Anemia].

    PubMed

    Duarte, Joana; Correia, Lurdes; Simão, Adélia; Figueiredo, António; Carvalho, Armando

    2015-01-01

    Introdução: A anemia hemolítica pode estar associada a múltiplas etiologias, nomeadamente a tóxicos, como os metais, sendo esta uma causa rara.Caso Clínico: Homem de 55 anos de idade, sujeito a artroplastia total da anca direita (prótese não cimentada com articulação cerâmica-cerâmica, cujo componente acetabular era constituído por uma cúpula metálica composta por uma liga de titânio, vanádio e alumínio na qual encaixava um insert cerâmico). Cerca de quatro anos após esta intervenção cirúrgica referia ruídos na prótese com os movimentos. Foi sujeito a revisão cirúrgica tendo-se constatado a presença de líquido espesso intracapsular de cor escura, fractura do insert acetabular cerâmico e sinais de desgaste da cúpula metálica acetabular. Procedeu-se a lavagem abundante e substituição do insert cerâmico fracturado por um insert de polietileno. Dois meses depois recorreu ao Serviço de Urgência por degradação do estado geral, flutuação na anca direita e icterícia muco-cutânea. Analiticamente evidenciava valores compatíveis com anemia hemolítica autoimune. Foi feita punção articular com saída de abundante líquido metalótico. A tomografia computorizada revelou extensa colecção heterogénea quística intrapélvica com múltiplos fragmentos de prótese no seu interior, sugestivos de metalose. A anemia hemolítica foi interpretada como consequência da toxicidade das partículas e iões metálicos oriundos do desgaste da prótese. Iniciou corticoterapia em altas doses e posteriormente quando houve condições procedeu-se à substituição de todos os componentes da prótese e drenagem do material acumulado intra-pélvico.Discussão: Após a fractura do insert cerâmico a cabeça cerâmica passou a articular directamente com o componente acetabular metálico, originando os ruídos e desgaste com libertação de partículas e iões. Este material formou uma coleção quística intrapélvica, que passou despercebida na

  11. [Congenital Anomalies Detected at Birth in Newborns of Adolescent Women].

    PubMed

    dos Reis, Leandro Valim; Araujo Júnior, Edward; Guazzelli, Cristina Aparecida Falbo; Cernach, Mirlene Cecilia Soares Pinho; Torloni, Maria Regina; Moron, Antonio Fernandes

    2015-01-01

    Introdução: Analisar a prevalência das anomalias congénitas, detetadas no nascimento, entre filhos de gestantes adolescentes, enfatizando os tipos mais comuns e a época do diagnóstico. Material e Métodos: Estudo retrospetivo do tipo censo, no qual foram analisados todos recém-nascidos, vivos ou mortos, com peso superior a 500 g, de mulheres que tiveram o parto no Hospital São Paulo num período de seis anos. Os produtos da conceção portadores de anomalias foram identificados no período pré-natal ou através do exame físico pós-natal, segundo os critérios do Estudo Colaborativo Latino-Americano das Malformações Congênitas. Os resultados são apresentados de forma descritiva através de valores absolutos e relativos, calcula-se a prevalência das anomalias e comparam-se os diferentes grupos recorrendo a testes não paramétricos. Resultados: Foram analisadas 6 257 gestações, das quais 577 resultaram em recém-nascidos com alguma anomalia congénita identificada no nascimento (prevalência de 9,2%). Do total de gestações, 907 eram de adolescentes (idade inferior a 20 anos), para as quais se verificou uma prevalência de anomalias nos recém-nascidos de 9,9%. Comparando os recém-nascidos de adolescentes com os das mulheres com idade superior a 20 anos, apenas se encontrou diferença estatisticamente significativa para a prevalência dos defeitos do tubo neural (p = 0,027). Discussão: Observamos uma alta taxa de partos em adolescentes, acima das taxas dos países desenvolvidos. Observamos também alta frequência de anomalias congénitas em recém-nascidos, provavelmente por sermos um serviço terciário de referência. A elevada prevalência dos defeitos do tubo neural entre grávidas jovens pode ser explicada pela não suplementação pré-concecional de ácido fólico em gravidezes não planeadas, como é característico nas adolescentes.Conclusão: A prevalência e momento do diagnóstico das anomalias congénitas em rec

  12. [Meningococcal disease admissions in a paediatric intensive care unit].

    PubMed

    Mação, Patrícia; Januário, Gustavo; Ferreira, Sofia; Dias, Andrea; Dionísio, Teresa; Pinto, Carla; Carvalho, Leonor

    2014-01-01

    Introdução: A infecção meningocócica tem uma elevada mortalidade e morbilidade em crianças. O tratamento agressivo do choque, a referenciação precoce, o transporte secundário especializado e a vacinação são factores com impacto potencial na redução da mortalidade. Foram objectivos caracterizar as crianças com doença invasiva meningocócica admitidas em cuidados intensivos, avaliar parâmetros de gravidade e mortalidade. Material e Métodos: Estudo observacional, cujo método de colheita de dados foi retrospectivo. Foram constituídos dois períodos, de seis anos cada, de acordo com o ano de admissão (A: 2000-2005 e B: 2006-2011) e nestes compararam-se índices de gravidade, disfunção orgânica e mortalidade. Resultados: Foram admitidas 70 crianças com doença invasiva meningocócica. Quando comparadas com as outras causas verificouse uma redução nas admissões por doença invasiva meningocócica (período A: 3,4%; período B: 1,5%; p = 0,001). A ocorrência de meningite foi de 41% no período A e de 29% no período B (p = 0,461). Tiveram púrpura rapidamente progressiva 78% no período A e 50% no período B (p = 0,0032). As crianças do período A tiveram disfunção multi-órgão (80%), coagulação intravascular disseminada (76%) e coma (22%) mais frequentemente que as crianças do período B (29%, 29%, 0%; p < 0,05). A mortalidade foi 26% no período A e 0% no período B (p = 0,006) e a mortalidade estandardizada pelo PRISM foi 1,3 e 0 no período A e B respectivamente. Discussão: A redução do número de admissões por doença menigocócica invasiva pode ser explicada pela introdução da vacina anti-meningocócica C em 2006. Pensa-se que a redução da mortalidade observada, possa ser atribuível à melhoria da estabilização inicial e ao transporte secundário. Conclusão: Nos últimos anos houve uma redução significativa no número de admissões e na mortalidade por doença invasiva meningocócica.

  13. [Brucellar spondylodiscitis: case series of the last 25 years].

    PubMed

    Lebre, Ana; Velez, Jorge; Seixas, Diana; Rabadão, Eduardo; Oliveira, Joaquim; Saraiva da Cunha, J; Silvestre, A Meliço

    2014-01-01

    Introdução: A brucelose é uma zoonose endémica em Portugal, sendo a espondilodiscite brucélica uma das manifestações focaismais frequentes. Pode provocar sequelas graves, apesar da terapêutica dirigida.Material e Métodos: Estudo retrospectivo dos processos dos doentes com espondilodiscite brucélica, internados no Serviço de Doenças Infecciosas do Centro Hospitalar e Universitário de Coimbra, num período de 25 anos (1988-2012).Resultados: Foram identificados 54 doentes, 55,6% do sexo masculino, com idade média de 54,8 anos. Em 81,5% identificou-se contexto epidemiológico, maioritariamente contacto com gado ovino e caprino. A duração da sintomatologia prévia ao diagnóstico foi de 5,5 meses. Os sinais e sintomas mais frequentes foram: dor (98,1%), febre (46,3%) e défices neurológicos (25,9%). A ressonância magnética nuclear da coluna foi o exame imagiológico mais usado (77,8%) evidenciando abcessos em 29,6% dos doentes. A localizaçãolombar predominou (77,7%). O diagnóstico etiológico foi confirmado em 47 doentes (87,0%): microbiologicamente (3 doentes), serologicamente (32 doentes) ou por ambos (12 doentes). As associações de doxiciclina com rifampicina (64,8%), ou estreptomicina (24,1%) foram as mais utilizadas, com duração média de 4,4 meses de tratamento. Um doente teve indicação cirúrgica para drenar abcesso. A evolução foi maioritariamente favorável (92,6%), sem óbitos.Discussão: A investigação de contexto epidemiológico revelou ser uma peça importante na suspeita do diagnóstico. O tratamento da brucelose osteoarticular ainda é controverso.Conclusões: A espondilodiscite brucélica deve ser considerada no diagnóstico diferencial dos doentes com lombalgia, mesmo naausência de febre, particularmente em regiões onde a doença é endémica. O esquema antibiótico, sua duração e a necessidade de cirurgia deverão ser individualizados, com vista a um melhor prognóstico. O número de casos tem diminuído ao longo dos

  14. Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience.

    PubMed

    Dantas Brito, Margarida; Campilho, Fernando; Branca, Rosa; Vaz, Carlos; Roncon, Susana; Campos, António

    2016-03-01

    Introdução: O linfoma não Hodgkin difuso de grandes células B pode ser curado em 60% - 70% dos doentes. O transplante autológo de progenitores hematopoiéticos é o tratamento de intenção curativa standard à recidiva. Este tratamento intensivo após primeira remissão num grupo selecionado de doentes de alto risco é controverso e fez parte da estratégia do nosso Serviço durante alguns anos. Material e Métodos: Estudo retrospectivo, consulta do processo clínico. Resultados: Este estudo analisa o outcome de 113 doentes transplantados entre 1992 e 2012. Formaram-se quatro grupos com base no status pré-transplante: a) primeira remissão completa após 1 ciclo de quimioterapia (n = 64); b) segunda remissão completa após ≥ duas linhas de quimioterapia (n = 15); c) segunda remissão completa (n = 15); d) doença mais avançada (n = 19). O protocolo de quimioterapia de primeira linha mais utilizado foi R-CHOP (n = 71) e CHOP (n = 28). O seguimento mediano foi de 34 meses (1 - 221). Aos cinco anos a sobrevivência global foi de 73% (± 5) e a sobrevivência livre de progressão 75% (± 5). Conclusão: A imunoquimioterapia convencional seguida de transplante autólogo é uma opção segura e eficaz no tratamento de casos selecionados de linfoma difuso de grandes células B. Na nossa casuística cerca de 70% dos doentes de alto risco atingiram remissões duráveis com esta estratégia terapêutica.

  15. A Concepção de Universo entre Alunos do Ensino Médio de São Paulo e suas Fontes de Aquisição

    NASA Astrophysics Data System (ADS)

    Araújo, M. A. A.; Elias, D. C. N.; Amaral, L. H.; Araújo, M. S. T.; Voelzke, M. R.

    2006-08-01

    Nesse trabalho procurou-se identificar por meio de um questionário as concepções de Universo, de espaço e tempo que sustentam a visão de mundo de um grupo de 270 estudantes de Ensino Médio, pertencentes a três escolas de São Paulo. As questões relacionadas aos conhecimentos prévios dos estudantes permitiram constatar que há pouco conhecimento acerca dos temas investigados, destacando-se que apenas 20% dos alunos foram capazes de relacionar as semanas com as fases da lua, enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra e 23% tinham noções das distâncias entre objetos celestes próximos da Terra. Enquanto 56% conseguiram relacionar o Big Bang com a origem do Universo, verificou-se que 37% reconheciam ano-luz como unidade de distância e 60% concebiam o Sol como uma estrela. No que se refere às fontes de aquisição que proporcionaram esses conhecimentos, apesar de 60% dos alunos indicarem a escola como principal fonte dos conhecimentos de Ast! ronomia, verificou-se claramente que para a maioria dos alunos seus conceitos ainda são inadequados, havendo necessidade de aprimoramento da abordagem desses conteúdos, pois apesar de popular, a Astronomia ainda é veiculada de maneira pouco esclarecedora e com imprecisões. Nesse contexto, são discutidas algumas possíveis contribuições que podem ser dadas para o ensino de Astronomia pelo uso das ferramentas computacionais nas escolas.

  16. Modelagem do vento e da fotosfera de AG Carinae

    NASA Astrophysics Data System (ADS)

    Groh, J. H.; Damineli, A.

    2003-08-01

    A trajetória evolutiva das estrelas de alta massa depende fortemente de suas taxas de perda de massa. Apesar do rápido progresso no estudo destas estrelas, a taxa de perda de massa e outros parâmetros físicos básicos, como a temperatura superficial e a velocidade terminal do vento ainda não estão bem determinados. Isto ocorre devido à presença de ventos irregulares, rápidos e fortes ao redor destas estrelas, tornando a interpretação dos seus espectros uma tarefa difícil. Assim, a modelagem do vento e da fotosfera dessas estrelas está sendo cada vez mais usada para obter tais parâmetros a partir dos espectros. O aumento da taxa de perda de massa durante a fase LBV (Variáveis Luminosas Azuis), comparado com outros tipos de estrelas, tem sido atribuído a instabilidades do tipo S Doradus. Dispomos de uma base de dados espectroscópicos cobrindo 22 anos de observações de AG Carinae, incluindo um ciclo S Doradus completo, com espectros CCD em alta resolução na faixa óptica e infravermelha. Utilizamos o programa desenvolvido por Schmutz (1997) para uma análise preliminar desse ciclo, obtendo a taxa de perda de massa a partir da linha do Ha. Não existe uma correlação clara da taxa de perda de massa com mudanças da temperatura efetiva, do raio da estrela e do fluxo na banda V. A estrela atingiu seu mínimo fotométrico (raio mínimo) em 1990 e o máximo fotométrico (raio máximo) em 1995, enquanto que o fluxo máximo da linha do Ha ocorreu em 1996. Além disso a taxa de perda de massa não segue esse ciclo, contrariamente às idéias correntes. Para fazer um modelo mais realista estamos usando o programa CMFGEN (Hillier & Miller), que trata a fotosfera e o vento estelar de forma consistente, considerando a radiação fora do equilíbrio termodinâmico (NLTE) e com blanketting total de linhas. Simulamos o espectro de AG Carinae em duas épocas extremas do ciclo S Dor para testar os resultados obtidos com o modelo mais simplificado.

  17. [Fibrinolytics in the Treatment of Complicated Pleural Effusions].

    PubMed

    Coelho, Ana; Coelho, Margarida; Pereira, Joana; Lavrador, Vasco; Morais, Lurdes; Carvalho, Fátima

    2016-11-01

    Introdução: A instilação intrapleural de fibrinolítico, no tratamento dos derrames pleurais parapneumónicos complicados, tem demonstrado resultados equivalentes ao tratamento cirúrgico. Este estudo foi realizado para avaliar e descrever os resultados da aplicaçãode fibrinolítico no tratamento de derrame pleural parapneumónico complicado, nos doentes seguidos no nosso hospital. Material e Métodos: Revisão retrospetiva, entre janeiro de 2005 e dezembro de 2013, dos doentes (idade superior a um mês e inferior a 18 anos) com diagnóstico de derrame pleural parapneumónico complicado, submetidos a colocação de dreno torácico e instilação intrapleural de fibrinolítico. Resultados: Identificaram-se um total de 37 doentes. A duração média do internamento foi de 17 ± 7,60 dias. Na maioria dos doentes (89,2%) o dreno torácico foi colocado nas primeiras 48 h após admissão, com seis dias de média de drenagem. Verificou-se falência terapêutica em 2,7% dos casos, por recidiva do derrame. Este doente foi submetido a toracoscopia videoassistida com necessidade de conversão do procedimento para toracotomia. A evolução clínica foi favorável em 96,9% dos casos. Discussão: Na nossa revisão a taxa de sucesso terapêutico encontra-se dentro do esperado, com uma percentagem de falência inferior ao descrito na literatura. Apresentamos a instilação intrapleural de fibrinolítico e a toracoscopia videoassistida num mesmo protocolo de atuação, tendo como primeira linha terapêutica o fibrinolítico. Conclusão: A opção terapêutica apresentada teve uma baixa taxa de falência e permitiu evitar um procedimento cirúrgico mais agressivo. Consideramos que esta é uma opção de tratamento eficaz e que, na nossa amostra, cursou com uma baixa taxa de sequelas.

  18. Compilação de dados atômicos e moleculares do UV ao IV próximo para uso em síntese espectral

    NASA Astrophysics Data System (ADS)

    Coelho, P.; Barbuy, B.; Melendez, J.; Allen, D. M.; Castilho, B.

    2003-08-01

    Espectros sintéticos são utéis em uma grande variedade de aplicações, desde análise de abundâncias em espectros estelares de alta resolução ao estudo de populações estelares em espectros integrados. A confiabilidade de um espectro sintético depende do modelo de atmosfera adotado, do código de formação de linhas e da qualidade dos dados atômicos e moleculares que são determinantes no cálculo das opacidades da fotosfera. O nosso grupo no departamento de Astronomia no IAG tem utilizado espectros sintéticos há mais de 15 anos, em aplicações voltadas principalmente para a análise de abundâncias de estrelas G, K e M e populações estelares velhas. Ao longo desse tempo, as listas de linhas vieram sendo construídas e atualizadas continuamente, e alguns acréscimos recentes podem ser citados: Castilho (1999, átomos e moléculas no UV), Schiavon (1998, bandas moleculares de TiO) e Melendez (2001, átomos e moléculas no IV próximo). Com o intuito de calcular uma grade de espectros do UV ao IV próximo para uso no estudo de populações estelares velhas, se fazia necessário compilar e homogeneizar as diversas listas em apenas uma lista atômica e uma molecular. Nesse processo, a nova lista compilada foi correlacionada com outras bases de dados (NIST, Kurucz Database, O' Brian et al. 1991) para atualização dos parâmetros que caracterizam a transição atômica (comprimento de onda, log gf e potencial de excitação). Adicionalmente as constantes de interação C6 foram calculadas segundo a teoria de Anstee & O'Mara (1995) e artigos posteriores. As bandas moleculares de CH e CN foram recalculadas com o programa LIFBASE (Luque & Crosley 1999). Nesse poster estão detalhados os procedimentos citados acima, as comparações entre espectros calculados com as novas listas e espectros observados em alta resolução do Sol e de Arcturus, e uma análise do impacto decorrente da utilização de diferentes modelos de atmosfera no espectro sintético. Ao

  19. [Pulmonary carcinoid: analysis of a single institutional experience and prognostic factors].

    PubMed

    Correia, Silvia da Silva; Pinto, Carlos; Bernardo, João

    2014-01-01

    IntroduçÉo: Os tumores carcinóides pulmonares sÉo tumores raros com origem nas células neuro-endócrinas do pulmÉo. Classificam-se de acordo com os critérios da OMS em carcinóides típicos ou atípicos. Quando comparados com outros tipos de neoplasia pulmonar, os tumores carcinóides apresentam melhor prognóstico.Objetivos: CaracterizaçÉo dos doentes com diagnóstico histológico de tumor carcinóide observados numa instituiçÉo. Análise dos fatores que influenciaram o prognóstico.Material e Métodos: Análise retrospetiva incluindo todos os doentes com diagnóstico histológico de tumor carcinóide pulmonar durante um período de 11 anos numa instituiçÉo. Os tumores foram classificados em típicos e atípicos de acordo com a classificaçÉo da OrganizaçÉo Mundial de Saúde de 2004. O estadiamento foi feito com base na classificaçÉo TNM de 2009 para o carcinoma do pulmÉo de nÉo pequenas células: T (Tumor); N (Ganglionar); M (Metástase).Resultados: Foram incluídos 59 doentes: 53 carcinóides típicos e seis carcinóides atípicos. Destes, 90% foram submetidos a cirurgia. O follow-up médio foi de 57 meses. A mortalidade operatória foi de 2% (n = 1) tratando-se de cirurgia paliativa para um doente em estádio IV. Em 49 doentes nÉo se verificou envolvimento ganglionar (N0), um doente apresentava doença N1, oito doença N2 e um doente doença N3. A sobrevivência global aos cinco anos foi de 79,2%: 80,2% nos carcinóides típicos e 66,7% nos carcinóides atípicos (p < 0,05). Nos doentes T1, a sobrevivência foi de 88,1% e de 58,2% nos T2-T4 (p < 0,01). Nos doentes N0 a sobrevivência aos cinco anos de 89,7% e de 36% para os doentes N1-N3 (p < 0,001). Os doentes com doença M0 apresentaram uma sobrevivência aos cinco anos de 85,9% sendo de 0% nos doentes M1 (p < 0,01). Dos 11 doentes que necessitaram de quimioterapia adjuvante, 45,4% eram carcinóides atípicos.DiscussÉo: Na nossa série, a cirurgia no tumor carcinóide pulmonar demonstrou

  20. "Canteiro Escola"--Uma Resposta da Industria da Construcao no Contexto Produtivo Atual (The "Building Site" School--A Construction Industry Answer in the Actual Productive Context).

    ERIC Educational Resources Information Center

    Barone, Rosa Elisa; Letelier, Maria Eugenia

    1995-01-01

    Presents examples of the discourse of construction industry personnel involved in workplace basic education in Brazil. Reports on the perspective of the workers/students and on the experiences and the vision of those who implement the educational programs. Identifies the limits of the schooling process and the difficulties inherent in the present…

  1. Decolourisation Capabilities of Ligninolytic Enzymes Produced by Marasmius cladophyllus UMAS MS8 on Remazol Brilliant Blue R and Other Azo Dyes

    PubMed Central

    Roslan, Hairul Azman

    2017-01-01

    Marasmius cladophyllus was examined for its ability to degradatively decolourise the recalcitrant dye Remazol Brilliant Blue R (RBBR) and screened for the production of ligninolytic enzymes using specific substrates. Monitoring dye decolourisation by the decrease in absorbance ratio of A592/A500 shows that the decolourisation of RBBR dye was associated with the dye degradation. Marasmius cladophyllus produces laccase and lignin peroxidase in glucose minimal liquid medium containing RBBR. Both enzyme activities were increased, with laccase activity recorded 70 times higher reaching up to 390 U L−1 on day 12. Further in vitro RBBR dye decolourisation using the culture medium shows that laccase activity was correlated with the dye decolourisation. Fresh RBBR dye continuously supplemented into the decolourised culture medium was further decolourised much faster in the subsequent round of the RBBR dye decolourisation. In vitro dye decolourisation using the crude laccase not only decolourised 76% of RBBR dye in just 19 hours but also decolourised 54% of Orange G and 33% of Congo red at the same period of time without the use of any exogenous mediator. This rapid dye decolourisation ability of the enzymes produced by M. cladophyllus thus suggested its possible application in the bioremediation of dye containing wastewater. PMID:28168194

  2. BVRI Photometric 2015 WD Analysis of the Southern Totally Eclipsing, Solar-type, Shallow-contact W UMa Binary, DD Indus

    NASA Astrophysics Data System (ADS)

    Samec, Ronald G.; Norris, Cody L.; Van Hamme, Walter; Faulkner, Danny R.; Hill, Robert L.

    2016-12-01

    Observations and a 2015 Wilson-Devinney Program analysis are undertaken for the first precision observations of DD Indi. DD Indi is of solar-type (T 1 ˜ 5750 K) and was determined to be a shallow-contact eclipsing binary. It was observed from 2013 June through September at Cerro Tololo InterAmerican Observatory in remote mode. The 24 inch Boller and Chivens reflector, now under management by The Southeastern Association for Resarch in Astronomomy (SARA) was used. Five new eclipse timings were obtained, for three primary and two secondary eclipses. Seven more eclipse timings were calculated from All Sky Automated Survey data. A possibly increasing period was found from all available eclipse timings with a 5 ± 2 × 10-11 × E 2 quadratic term. A BVR c I c simultaneous synthetic light-curve analysis reveals that the system has a mass ratio of ˜0.46, a ˜ 140 K component temperature difference, and two weak cool spots. The Roche Lobe fill-out of this W-type binary is only ˜11%, and an inclination of ˜86° was determined. A time of constant light of ˜16 minutes is measured around phase zero. More detail is included in this report.

  3. "Canteiro Escola"--Uma Resposta da Industria da Construcao no Contexto Produtivo Atual (The "Building Site" School--A Construction Industry Answer in the Actual Productive Context).

    ERIC Educational Resources Information Center

    Barone, Rosa Elisa; Letelier, Maria Eugenia

    1995-01-01

    Presents examples of the discourse of construction industry personnel involved in workplace basic education in Brazil. Reports on the perspective of the workers/students and on the experiences and the vision of those who implement the educational programs. Identifies the limits of the schooling process and the difficulties inherent in the present…

  4. Uma Comparação entre Técnicas de Propagação de Erros em Astrofísica: Monte Carlo x Bootstrap

    NASA Astrophysics Data System (ADS)

    Zabot, Alexandre; Baptista, Raymundo

    2005-07-01

    Neste trabalho é feito um estudo comparativo entre dois algoritmos numéricos usados para propagação de erros em dados experimentais. Um deles é conhecido por Método de Monte carlo e o outro por Método de Bootstrap. Recentemente, Dhullon & Watson argüiram que a aplicação do método de Monte Carlo introduz ruído nos dados, e propuseram então a utilização do Bootstrap como alternativa capaz de produzir resultados superiores. O objetivo deste trabalho é testar a validade dessa afirmação. As duas técnicas foram aplicadas a três problemas diferentes: o ajsute de modelos de emissão LTE simples e atmosfera estelar a espectros estelares observados e o ajuste de curvas de luz de eclipses de Variáveis Cataclísmicas para a detemrinação da distribuição radial de brilho dos seus discos de acréscimo. Os métodos foram testados quanto à sua robusteza, ou seja, a capacidade de prover resultados coerentes enre si. Além disso, as soluções dos métodos foram comparadas. Os resultados indicam que não existe evidência de superioridade de um métodos em relação ao outro.

  5. Decolourisation Capabilities of Ligninolytic Enzymes Produced by Marasmius cladophyllus UMAS MS8 on Remazol Brilliant Blue R and Other Azo Dyes.

    PubMed

    Sing, Ngieng Ngui; Husaini, Ahmad; Zulkharnain, Azham; Roslan, Hairul Azman

    2017-01-01

    Marasmius cladophyllus was examined for its ability to degradatively decolourise the recalcitrant dye Remazol Brilliant Blue R (RBBR) and screened for the production of ligninolytic enzymes using specific substrates. Monitoring dye decolourisation by the decrease in absorbance ratio of A592/A500 shows that the decolourisation of RBBR dye was associated with the dye degradation. Marasmius cladophyllus produces laccase and lignin peroxidase in glucose minimal liquid medium containing RBBR. Both enzyme activities were increased, with laccase activity recorded 70 times higher reaching up to 390 U L(-1) on day 12. Further in vitro RBBR dye decolourisation using the culture medium shows that laccase activity was correlated with the dye decolourisation. Fresh RBBR dye continuously supplemented into the decolourised culture medium was further decolourised much faster in the subsequent round of the RBBR dye decolourisation. In vitro dye decolourisation using the crude laccase not only decolourised 76% of RBBR dye in just 19 hours but also decolourised 54% of Orange G and 33% of Congo red at the same period of time without the use of any exogenous mediator. This rapid dye decolourisation ability of the enzymes produced by M. cladophyllus thus suggested its possible application in the bioremediation of dye containing wastewater.

  6. O Brincar como uma Acao Mediadora no Trabalho Desenvolvido com Criancas Hospitalizadas (Play as a Mediating Activity in Work Developed with Hospitalized Children).

    ERIC Educational Resources Information Center

    Goulart, Aurea Maria Paes Leme; de Moraes, Silvia Pereira Gonzaga

    2000-01-01

    Describes experiences with hospitalized children through the extension project "Writing and Reading at the University Hospital", State University of Maringa Hospital (Brazil). States the initial project proposal provided educational assistance to the children separated from school due to being in the hospital. Used play and games as an…

  7. Elemente der beiden W-UMa-Sterne GSC 0424-0792 (Brh V62) und GSC 1721-1591 (Brh V127)

    NASA Astrophysics Data System (ADS)

    Bernhard, Klaus; Frank, Peter; Moschner, Wolfgang

    2011-01-01

    CCD observations and ASAS-3 data of GSC 0424-0792 (Brh V62) and GSC 1721-1591 (Brh V127) lead to the following elements and types of variability: GSC 0424-0792: HJD (MinI)= 2453142.489(5)+ E*1.182336(1), type: WUMa GSC 1721-1591: HJD (MinI)= 2455429.5086(4)+E*0.3188963(1), type: WUMa

  8. Hypertriglyceridemic Waist Phenotype and Changes in the Fasting Glycemia and Blood Pressure in Children and Adolescents Over One-Year Follow-Up Period.

    PubMed

    Costa, Priscila Ribas de Farias; Assis, Ana Marlúcia Oliveira; Cunha, Carla de Magalhães; Pereira, Emile Miranda; Jesus, Gabriela Dos Santos de; Silva, Lais Eloy Machado da; Alves, Wilanne Pinheiro de Oliveira

    2017-07-01

    modelos de Equação de Estimulação Generalizada (GEE) foram calculados para avaliar a influência longitudinal do fenótipo CHT na glicemia e na pressão arterial ao longo de um ano. Foi observada uma prevalência de 10,6% (n = 52) do fenótipo CHT nos estudantes. Os modelos GEE identificaram que os estudantes com fenótipo CHT apresentaram aumento de 3,87 mg/dl na média de glicemia em jejum (IC: 1,68-6,05) e de 3,67 mmHg na pressão arterial sistólica media (PAS) (IC: 1,55-6,08) depois de um ano de acompanhamento, após ajuste para variáveis de confusão. Os resultados deste estudo sugerem que o fenótipo CHT é um fator de risco para alterações longitudinais da glicemia e da PAS em crianças e adolescentes em um período de um ano de seguimento.

  9. Analysis of the Economic Impact of Cardiovascular Diseases in the Last Five Years in Brazil.

    PubMed

    Siqueira, Alessandra de Sá Earp; Siqueira-Filho, Aristarco Gonçalves de; Land, Marcelo Gerardin Poirot

    2017-07-01

    There is growing concern about the economic impact of cardiovascular diseases (CVD) in Brazil and worldwide. To estimate the economic impact of CVD in Brazil in the last five years. The information to estimate CVD costs was taken from national databases, adding the direct costs with hospitalizations, outpatient visits and benefits granted by social security. Indirect costs were added to the calculation, such as loss of income caused by CVD morbidity or mortality. CVD mortality accounts for 28% of all deaths in Brazil in the last five years and for 38% of deaths in the productive age range (18 to 65 years). The estimated costs of CVD were R$ 37.1 billion in 2015, a 17% increase in the period from 2010 to 2015. The estimated costs of premature death due to CVD represent 61% of the total cost of CVD, Direct costs with hospitalizations and consultations were 22%, and costs related to the loss of productivity related to the disease were 15% of the total. Health expenditures in Brazil are estimated at 9.5% of GDP and the average cost of CVD was estimated at 0.7% of GDP. CVD costs have increased significantly in the last five years. It is estimated that CVD costs increase as the Brazilian population ages and the prevalence of CVD increases. Existe uma preocupação crescente com o impacto econômico das doenças cardiovasculares (DCV) no Brasil e no mundo. Estimar o impacto econômico das DCV no Brasil nos últimos cinco anos. As informações para estimar os custos em DCV foram retiradas de bancos de dados nacionais, somando os custos diretos com hospitalizações, atendimentos ambulatoriais e benefícios concedidos pela previdência. Custos indiretos foram acrescidos ao cálculo, como a perda de renda causada pela morbidade ou pela mortalidade da DCV. A mortalidade por DCV representa 28% do total de óbitos ocorridos no Brasil nos últimos cinco anos e atinge 38% dos óbitos na faixa etária produtiva (18 a 65 anos). Os custos estimados por DCV foram de R$ 37,1 bilh

  10. [Study of the Sociodemographic Factors and Risky Behaviours Associated with the Acquisition of Sexual Transmitted Infections by Foreign Exchange Students in Portugal].

    PubMed

    Gravata, Andreia; Castro, Rita; Borges-Costa, João

    2016-06-01

    Introdução: As infeções sexualmente transmissíveis são um problema de saúde pública, sendo mais frequentes em jovens. Este estudo teve como principal objetivo avaliar os fatores sociodemográficos e comportamentos associados à aquisição de infeções sexualmente transmissíveis e o conhecimento sobre infeção por Chlamydia trachomatis em estudantes estrangeiros em intercâmbio universitário em Portugal. Material e Métodos: Os fatores sociodemográficos e comportamentos de risco foram estudados por aplicação de um questionário a estudantes em intercâmbio universitário em Portugal, inscritos nos anos letivos de 2012/2013, 2013/2014 e 2014/2015. Resultados: Avaliaram-se 338 questionários: 58,3% participantes do sexo feminino e 40,8% do sexo masculino (17 aos 30 anos). A idade média apontada para o início da vida sexual foi de 17,5 anos e a média de parceiros sexuais de 6,9. Relativamente às questões inquiridas foi referido: 9,5% negaram atividade sexual oral; 29% com atividade sexual anal; 11,8% com atividade sexual com parceiros do mesmo género; 82,1% refere consumo de álcool/estupefacientes; 42,3% desconhecimento sobre a infeção por Chlamydia trachomatis e 21% sobre o risco de transmissão de infeção por via oral. Discussão: Apesar das infeções sexualmente transmissíveis poderem afetar indivíduos de todas as idades, raças e orientações sexuais, vários fatores demográficos, sociais e comportamentais têm revelado influência nas taxas de prevalência deste tipo de infeções.Conclusões: Nesta população os fatores de risco associados a uma maior prevalência de infeções sexualmente transmissíveis continuam a existir, nomeadamente início precoce da atividade sexual, parceiros sexuais múltiplos e ausência de medidas de proteção durante as relações sexuais.

  11. PREVALENCE OF HELICOBACTER PYLORI TEN YEARS AGO COMPARED TO THE CURRENT PREVALENCE IN PATIENTS UNDERGOING UPPER ENDOSCOPY.

    PubMed

    Frugis, Sandra; Czeczko, Nicolau Gregori; Malafaia, Osvaldo; Parada, Artur Adolfo; Poletti, Paula Bechara; Secchi, Thiago Festa; Degiovani, Matheus; Rampanazzo-Neto, Alécio; D Agostino, Mariza D

    2016-01-01

    Helicobacter pylori has been extensively studied since 1982 it is estimated that 50% of the world population is affected. The literature lacks studies that show the change of its prevalence in the same population over time. To compare the prevalence of H. pylori in 10 years interval in a population that was submitted to upper endoscopy in the same endoscopy service. Observational, retrospective and cross-sectional study comparing the prevalence of H. pylori in two samples with 10 years apart (2004 and 2014) who underwent endoscopy with biopsy and urease. Patients were studied in three consecutive months of 2004, compared to three consecutive months of 2014. The total number of patients was 2536, and 1406 in 2004 and 1130 in 2014. There were positive for H. pylori in 17 % of the sample as a whole. There was a significant decrease in the prevalence from 19.3% in 2004 to 14.1% in 2014 (p<0.005). There was a 5.2% reduction in the prevalence of H. pylori comparing two periods of three consecutive months with 10 years apart in two equivalent population samples. Helicobacter pylori vem sendo amplamente estudado desde 1982 estimando-se que 50% da população mundial esteja afetada. A literatura carece de estudos que mostrem a mudança de sua prevalência em uma mesma população ao longo do tempo. Comparar a prevalência do H.pylori no intervalo de 10 anos em população que realizou endoscopia digestiva alta no mesmo serviço de endoscopia. Estudo observacional, retrospectivo e transversal, comparando a prevalência de H. pylori em duas amostras com intervalo de 10 anos (2004 e 2014) que realizaram endoscopia digestiva alta com biópsias e teste da urease para a pesquisa de H. pylori. Foram estudados pacientes em três meses consecutivos de 2004, comparados aos de três meses consecutivos de 2014. O número total de pacientes avaliados foi 2536, sendo 1406 em 2004 e 1130 em 2014. Constatou-se resultado positivo para H.pylori em 17% da amostra como um todo. Houve queda

  12. [Streptococcus pneumoniae Vaccination in Children and Adolescents at High Risk of Invasive Pneumococcal Disease].

    PubMed

    Tendais-Almeida, Marta; Ferreira-Magalhães, Manuel; Alves, Inês; Tavares, Margarida; Azevedo, Inês

    2015-01-01

    Introdução: Em Portugal, a vacinação anti-pneumocócica é gratuita e recomendada pela Direção-Geral da Saúde na população pediátrica de alto risco para doença invasiva pneumocócica. O objetivo deste estudo foi analisar o cumprimento vacinal numa população pediátrica seguida em consulta hospitalar. Material e Métodos: Estudo observacional transversal, em crianças com diagnóstico de alto risco de doença invasiva pneumocócica e consulta num hospital nível três, entre julho e dezembro de 2014. Os dados foram obtidos através do processo clínico, Boletim Individual de Saúde e Plataforma de Dados da Saúde®. Resultados: Dos 122 participantes, 95,9% realizaram, pelo menos, uma dose de vacina mas, destes, só 64,8% efetuaram o esquema completo. O cumprimento do esquema vacinal foi melhor nos de idade inferior a cinco anos (p < 0,01). A proporção de crianças com esquema completo foi de: 100% nas hemoglobinopatias, 100% nas infeções por vírus da imunodeficiência humana, 66,7% nos prematuros com idade gestacional ⤠28 semanas, 62,5% nos esplenectomizados e 54,7% na síndrome de Down. As crianças têm mais esquemas completos quando são seguidas em consulta de Infeciologia (100%) e de Pneumologia pediátricas (88,2%). O grupocom idade superior a cinco anos está mais vacinado com a vacina polissacarida 23-valente do que o dos 2-5 anos (74,5% vs 40,5%; p < 0,01).Discussão: A maioria da nossa população de alto risco para doença invasiva pneumocócica efetuou vacinação anti-pneumocócica, mas apenas dois terços completaram o esquema recomendado, sendo a maior falha na administração da vacina polissacarida 23-valente. Conclusões: Embora estes resultados sejam melhores do que em países europeus com recomendações semelhantes, é necessário explorar as causas das falhas observadas para otimizar a vacinação.

  13. [The Epidemiology of Dementia and Alzheimer Disease in Portugal: Estimations of Prevalence and Treatment-Costs].

    PubMed

    Santana, Isabel; Farinha, Filipa; Freitas, Sandra; Rodrigues, Vítor; Carvalho, Ålvaro

    2015-01-01

    Introdução: A incidência e prevalência de demência e de Doença de Alzheimer aumentam com a idade, duplicando a cada cinco anos após a sexta década de vida. Portugal é um país envelhecido, previsivelmente com um número crescente de casos de demência. No entanto, os dados epidemiológicos são escassos e os estudos sobre os custos da doença praticamente inexistentes. Propomo-nos apresentar uma estimativa actualizada da prevalência de demência/ Doença de Alzheimer em Portugal e inferir, a partir da prescrição específica para demência, o número de diagnósticos efectivos e os encargos financeiros com esses medicamentos.Material e Métodos: ÃÄ população residente em Portugal (2013), aplicámos os valores de prevalência de demência para a Europa Ocidental (estudo da AlzheimerâÄôs Disease International). A estimativa dos diagnósticos efectivos de Doença de Alzheimer e dos encargos financeiros com medicação específica baseou-se nas informações do Intercontinental Marketing Services Health (IMSH) âÄì 2013.Resultados: O número estimado de Portugueses com mais de 60 anos e com demência foi 160287, o que corresponde a 5,91% deste universo populacional. Sabendo que a Doença de Alzheimer representa 50-70% dos casos, inferimos que existirão entre 80144 e 112201 doentes. Por outro lado, os dados da IMSH indicam que estarão diagnosticados e a receceber anti-demenciais 76250 doentes, representando um encargo financeiro de 37 MâǬ/ano.Conclusão: O envelhecimento da população incrementa o número de casos de demência. Aparentemente, nem todos os doentes com Doença de Alzheimer recebem a medicação aconselhada, sugerindo que esta condição ainda está sub-diagnosticada. A evolução tem sido positiva, com incremento do número de doentes tratados e redução dos custos com fármacos específicos.

  14. [Urinary tract infections in a cohort of kidney transplant recipients].

    PubMed

    Bispo, Ana; Fernandes, Milene; Toscano, Cristina; Marques, Teresa; Machado, Domingos; Weigert, André

    2014-01-01

    Introdução: A infeção do trato urinário é a complicação infeciosa mais comum no período pós transplante renal, estando a sua frequência pouco caracterizada na população portuguesa. Este trabalho teve como objetivo determinar a incidência de infeções do trato urinário e infeções do trato urinário recorrentes em transplantados renais. Material e Métodos: Tratou-se de um estudo observacional de coorte retrospetiva, com consulta dos processos clínicos de doentes transplantados entre Janeiro de 2004 e Dezembro de 2005, no Hospital de Santa Cruz, com seguimento durante cinco anos ou até à data de perda de enxerto, morte ou perda de follow-up. Após uma análise descritiva da população, utilizámos testes bivariados para identificação de fatores associados a infeções do trato urinário. Resultados: Em 127 doentes incluídos com seguimento de 593 doentes/ ano, 53 (41,7%) tiveram pelo menos um episódio de infeção do trato urinário e 21 (16,5%) tiveram infeções do trato urinário recorrentes. O género feminino foi o único fator associado com ocorrência de infeções do trato urinário (p < 0,001, OR = 7,08, RR = 2,95) e infeções do trato urinário recorrentes (p < 0,001, OR = 4,66, RR = 2,83). Os agentes etiológicos mais frequentes foram Escherichia coli (51,6%), Klebsiella pneumoniae (15,5%) e Enterobacter spp (9,9%). As infeções do trato urinário não causaram aumento de mortalidade ou perda de enxerto, mas foram a principal causa de internamentos hospitalares. Discussão: Na nossa população, apenas o género feminino foi identificado como fator de risco para o desenvolvimento de infeções do trato urinário, recorrentes ou não. Escherichia coli foi o agente etiológico mais frequente. Conclusão: Apesar das medidas preventivas adotadas, as infeções do trato urinário continuam a ser uma importante causa de morbilidade e de internamentos hospitalares.

  15. HOW TO EVALUATE SCIENTIFIC PRODUCTION.

    PubMed

    Antunes, Alberto Azoubel

    2015-01-01

    To conduct a critical analysis of the two main bibliometric indexes used by science: the impact factor and the H index. Research was conducted on PubMed using the keywords: impact factor, Bibliometrics and H index. The citations of articles tend to follow a curve in which the articles published in a given year increase sharply to a peak occurring between two and six years after its publication. From this peak citations decline over time. The analysis of the scientific merit should not be based on only in bibliometric measure, but in the association of various parameters. The impact factor and the H index is mainly based on the number of citations of scientific papers, and this parameter, although important, should not be used alone, nor overvalued in the evaluation of teaching merit. Realizar análise crítica dos dois principais índices bibliométricos utilizados pela ciência: o fator de impacto e o índice H. Foi realizada pesquisa no Pubmed utilizando as palavras-chave: impact factor, bibliometrics, H index. As citações dos artigos tendem a seguir uma curva em que os artigos publicados em determinado ano aumentam agudamente para um pico que ocorre entre dois e seis anos após sua publicação. A partir deste pico, as citações declinam ao longo do tempo. A análise do mérito científico não deve ser baseada em apenas uma medida bibliométrica, mas em associação de medidas. O FI e o índice H se baseiam fundamentalmente no número de citações dos artigos científicos, e este parâmetro, apesar de importante, não deve ser utilizado sozinho e tampouco supervalorizado na avaliação do mérito docente.

  16. Causes of Death in an Acute Psychiatric Inpatient Unit of a Portuguese General Hospital.

    PubMed

    Barbosa, Sofia; Sequeira, Márcia; Castro, Sara; Manso, Rita; Klut Câmara, Catarina; Trancas, Bruno; Borja-Santos, Nuno; Maia, Teresa

    2016-08-01

    Introdução: Os doentes afectos de patologia psiquiátrica apresentam maior risco de morte, tanto por causas naturais como não naturais. Este estudo avalia as causas de morte de todos os doentes de uma unidade de internamento de agudos de Psiquiatria num hospital geral em Portugal, ao longo de dezasseis anos (de 1998 a 2013). Material e Métodos: Vinte e um doentes morreram na unidade de internamento de doentes agudos entre 1998 e 2013 (média 1,3 por ano). As características demográficas, os diagnósticos médicos e psiquiátricos foram recolhidos através de um estudo retrospectivo que consistiu na análise dos processos clínicos da amostra selecionada. Os doentes transferidos para outras enfermarias durante o internamento não foram incluídos no estudo. Resultados: As doenças do sistema circulatório foram as causas de morte mais prevalentes, ocorrendo em 2/3 dos doentes, incluindo embolismo pulmonar (n = 6), acidente vascular cerebral (n = 3), arritmia cardíaca (n = 2), enfarte agudo do miocárdio (n = 1), rutura de aneurisma da aorta abdominal (n = 1) e insuficiência cardíaca (n = 1). Dois doentes morreram de pneumonia e em quatro casos a causa de morte foi indeterminada. Apenas um caso de suicídio foi registado. Discussão: As doenças do aparelho circulatório foram as causas de morte mais frequentes nesta unidade de agudos. O suicídio em doentes internados, apesar de constituir um evento raro, é uma realidade que comporta consequências complexas para os profissionais de saúde, familiares e restantes doentes, devendo permanecer como foco de prevenção continuada. Conclusão: Os estudos de mortalidade são importantes para determinar a qualidade dos cuidados de saúde e criar recomendações para medidas preventivas.

  17. Evolução química de galáxias HII anãs

    NASA Astrophysics Data System (ADS)

    Ferraresi, M., Jr.; Cuisinier, F.; Telles, E.

    2003-08-01

    Galáxias HII anãs são galáxias de baixa massa, com alto conteúdo de gás, e se encontram em uma fase intensa de formação estelar. A taxa de formação estelar está tão alta nestas galáxias que não pode ter se mantido durante sua vida inteira. O tempo máximo de duração do episódio atual de formação estelar deve ser no máximo de algumas dezenas de milhões de anos, bem inferior à idade destas galáxias. Isto leva naturalmente a idéia de que já aconteceram surtos anteriores. Abundâncias químicas oferecem uma ferramenta poderosa para investigar a história evolutiva destas galáxias, porque aumentam de geração em geração estelar. O hidrogênio, o oxigênio, o nitrogênio produzem algumas das linhas mais importantes em um gás foto-ionizado, permitindo a determinação das abundâncias destes elementos facilmente. A dispersão das abundâncias em oxigênio e nitrogênio é significativa, sendo maior que os erros observacionais. O oxigênio é produzido em estrelas massivas, que explodem quase instâneamente, enquanto o nitrogênio é produzido em estrelas de massa intermediária, que só o liberam depois de um atraso de @ 500 mihões de anos. Construímos um modelo de evolução química semi-analítico, utilizando rendimentos empíricos baseados nas abundâncias observadas destes dois elementos. Conseguimos através deste modelo rudimentar explicar nas galáxias de mais baixas metalicidades as abundâncias de oxigênio e de nitrogênio, assim como a dispersão dos dados observacionais devida a formação estelar descontínua, e isto com um número baixo de surtos (1 ou 2, no máximo 3).

  18. Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Polycystic Ovary Syndrome.

    PubMed

    Luz, Rita; Barros, Joana; Aguiar, Ana; Rodrigues, Cátia; Soares, Ana Paula; Nunes, Joaquim; Sousa, Sandra; Calhaz-Jorge, Carlos

    2016-08-01

    Introdução: A síndrome dos ovários poliquísticos é a causa mais frequente de anovulação e o tratamento envolve uma abordagem faseada. A electrocoagulação laparoscópica dos ovários é aceite como segunda linha no tratamento das doentes que não respondem ao citrato de clomifeno. Os objectivos deste estudo foram determinar a eficácia desta técnica a curto e longo prazo e definir os factores preditivos de gravidez espontânea. Material e Métodos: Este estudo retrospectivo envolveu 76 mulheres submetidas a electrocoagulação dos ovários entre 2004 e 2013, num hospital universitário. Os desfechos principais foram a regularidade menstrual e gravidez. Os resultados a curto prazo registados durante a vigilância na unidade foram revistos e os desfechos a longo prazo foram avaliados através de entrevista telefónica realizada a todas as mulheres operadas há mais de três anos. Dados clínicos e bioquímicos foram analisados como factores preditivos de gravidez espontânea em doentes sem outros factores de infertilidade. Resultados: A regularidade do ciclo menstrual foi alcançada inicialmente em 53 (70%) mulheres e a longo prazo, 52% (12/53) tinham ciclos regulares. Em geral, 53 (70%) mulheres engravidaram e foram obtidas 77 gravidezes, 60% das quais foram espontâneas. O único factor de prognóstico associado a gravidez espontânea foi a duração da infertilidade inferior a três anos (p < 0,05). Discussão: A electrocoagulação dos ovários demonstrou taxas de gravidez comparáveis a outros tratamentos de indução da ovulação com a vantagem de ter efeitos benéficos duradouros na regularidade menstrual e fertilidade. Conclusão: A electrocoagulação dos ovários é uma opção de tratamento segura e eficaz na infertilidade anovulatória em mulheres com síndrome dos ovários poliquísticos.

  19. Tendências de teses e dissertações sobre ensino de astronomia no Brasil

    NASA Astrophysics Data System (ADS)

    Bretones, P. S.; Megid Neto, J.

    2003-08-01

    Neste trabalho são apresentados os resultados de uma pesquisa do tipo estado da arte sobre teses e dissertações defendidas no Brasil e relativas ao ensino de Astronomia. Teve por objetivo identificar essa produção e conhecer as principais tendências da pesquisa nesse campo. O procedimento inicial consistiu de um levantamento bibliográfico junto ao Centro de Documentação em Ensino de Ciências (CEDOC) da Faculdade de Educação da UNICAMP e ao Banco de Teses da CAPES disponível na Internet. Foram localizadas 13 dissertações de mestrado e 3 teses de doutorado, as quais foram estudadas em função dos seguintes aspectos: instituição, ano de defesa, nível escolar abrangido no estudo, foco temático do estudo e gênero de trabalho acadêmico. Deste conjunto de pesquisas, 13 (81,3%) delas foram defendidas a partir da segunda metade dos anos 90, indicando uma preocupação mais recente com temas relativos ao ensino de Astronomia no conjunto da produção acadêmica em programas de pós-graduação no Brasil. Verificou-se que 43,7% dos trabalhos foram produzidas na USP e 18,8% na UNICAMP. Quanto ao nível escolar abrangido nos estudos, predominaram os estudos direcionados ao Ensino Fundamental de 5a a 8a séries (62,5%). No que diz respeito ao foco temático das pesquisas, as principais tendências voltaram-se: 56,3% para Conteúdo e Método; 43,8% para Concepções do Professor; 37,5% para Currículo e Programas; 37,5% para Recursos Didáticos. Quanto ao gênero de trabalho acadêmico, verificou-se que 43,8% são de Pesquisa Experimental e 31,3% de Pesquisa de Análise de Conteúdo. Estudos de revisão bibliográfica como este visam colaborar com a divulgação ampla da produção acadêmica em determinada área, traçando algumas de suas tendências. Ao mesmo tempo possibilita, a partir de investigações decorrentes, apontar as suas contribuições para o ensino e sinalizar com necessidades a serem supridas por futuras pesquisas.

  20. Hansen Neuropathy: Still a Possible Diagnosis in the Investigation of a Peripheral Neuropathy.

    PubMed

    Veiga, Andreia; Costa, Alexandre; Taipa, Ricardo; Guimarães, António; Pires, Manuel Melo

    2015-01-01

    Introdução: A lepra continua a ser uma das causas mais frequentes de neuropatia periférica. Apesar de tida como erradicada em Portugal, ainda se documenta no estudo neuropatológico de doentes com clínica de neuropatia periférica sem diagnóstico etiológico definido.Material e Métodos: Revisão dos casos neuropatia por doença de Hansen diagnosticados na Unidade de Neuropatologia do Centro Hospitalar do Porto no período de 1978 e 2013 atendendo ao género, idade, manifestações clínicas e achados neuropatológicos.Resultados: Foram identificados 21 doentes com diagnóstico neuropatológico de neuropatia por doença de Hansen, com predomínio do sexo masculino. A idade média ao diagnóstico foi de 52 anos, sendo a sintomatologia sensitiva predominante. O intervalo entre sintomatologia e diagnóstico oscilou entre 1 a 38 anos. Na maioria foi identificada forma tuberculoide em biópsia de nervo e detetados bacilos em pele e nervo em 44% dos casos.Discussão: A mononeurite é a forma mais comum de apresentação de hanseníase, podendo cursar com outras manifestações clínicas incluindo lesões cutâneas. A infeção pelo M. leprae lesiona fibras mielinizadas e não mielinizadas, com substituição do tecido nervoso por colagénio resultando em fibrose. O diagnóstico da lepra é apenas conseguido por estudo neuropatológico das lesões cutâneas e/ou nervo periférico, adjuvado pela identificação do bacilo.Conclusão: A doença de Hansen continua a ser um problema de saúde pública em áreas tropicais e, apesar de rara, ainda descrita em países ocidentais, devendo ser considerada como uma hipótese de diagnóstico na investigação de neuropatia periférica.

  1. Fungus ball of the paranasal sinuses: Report of two cases and literature review.

    PubMed

    Bosi, Guilherme Rasia; de Braga, Gustavo Lisbôa; de Almeida, Tobias Skrebsky; de Carli, Adriana

    2012-04-01

    Introdução: Bola fúngica dos seios paranasais é uma infecção não invasiva que se caracteriza por sua cronicidade, sendo a maioria relacionada com tratamento endodôntico prévio. Acomete principalmente o seio maxilar, embora todos os seios possam ser envolvidos. O principal agente etiológico é o Aspergillus spp. A tomografia computadorizada, devido às apresentações radiológicas características, sugere o diagnóstico que é realizado definitivamente através de análises histopatológicas. O tratamento padrão-ouro é a cirurgia sinusal endoscópica com antrostomia meatal média.Objetivo: Relatar dois casos de bola fúngica dos seios paranasais e ressaltar aspectos importantes desta patologia.Relato dos Casos: Caso 1) Paciente do sexo feminino, 78 anos, apresentou-se com queixas de dor facial há 6 meses e história prévia de tratamento endodôntico. Ao exame físico constatou-se a presença de secreção purulenta em meato médio esquerdo. O Raio X apresentou velamento completo do seio maxilar esquerdo, enquanto a tomografia computadorizada mostrou lesão calcificada neste local. Realizou-se sinusotomia que evoluiu bem. Caso 2) Paciente do sexo feminino, 70 anos, procurou atendimento por história de sinusites de repetição. Ao exame físico não se percebeu nenhuma particularidade. A tomografia computadorizada, assim como a ressonância magnética, detectou espessamento da parede mucosa do seio maxilar esquerdo, além de uma massa calcificada. Realizou-se a mesma sequência de tratamento e a paciente também evoluiu bem.Considerações finais: A infecção fúngica deve ser considerada nos pacientes que se apresentam com sinusite crônica, que não respondem ao uso de antibióticos e que possuem história de manipulação endodôntica.

  2. On Ensino da Astronomia no Ensino Médio sob Diferentes Abordagens Metodológicas

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; Albrecht, Evonir

    2011-12-01

    O presente trabalho, sobre a intervenção de metodologias de ensino, foi desenvolvido na Escola Estadual Colônia dos Pescadores, na cidade de Caraguatatuba - SP, em três turmas do terceiro ano do Ensino Médio, perfazendo um total de 119 educandos, entre 16 e 19 anos. Antes de iniciar-se a intervenção, um questionário de vinte perguntas objetivas e dissertativas foi desenvolvido, aplicado pelo professor da classe, que ministrou as aulas correspondentes. Este questionário foi o mesmo em todas as três classes com o objetivo de diagnosticar o conhecimento prévio dos alunos sobre Astronomia. Começando a intervenção nas turmas, o professor envolvido usou três diferentes metodologias de ensino: (A) em forma de seminários, elaborados e apresentados pelos alunos, nos quais o professor fazia apenas as intervenções necessárias, (B) na forma tradicional, com a ajuda de multimídia para o desenvolvimento das aulas e a terceira (C) a tradicional, fazendo uso exclusivo de lousa e giz. No final do trabalho os alunos responderam o mesmo questionário novamente, de modo que os três métodos utilizados puderam ser comparados. Os resultados apresentados após a intervenção foram melhores que os resultados iniciais indicando a ocorrência de uma aprendizagem significativa. Quando os estudantes foram inicialmente questionados sobre quantos planetas existem no nosso sistema solar, a classe A obteve 39% de respostas certas, a classe B 48% e a classe C 46%, mas após o desenvolvimento das atividades, as classes obtiveram respectivamente 94%, 97 % e 90% de aproveitamento. No término do bimestre, foi sugerido aos educandos que elaborassem uma história em quadrinhos, a qual serviu para averiguar se os conceitos inicialmente observados foram alterados e se novos foram agregados. A análise das histórias foi dividida em três partes: Criatividade; Temas abordados; Emprego correto dos conceitos estudados. Ao final quatorze histórias foram confeccionadas. O aprendizado

  3. [Relational and reproductive trajectories leading to adolescent pregnancy in Portugal: a national and regional characterization].

    PubMed

    Pires, Raquel; Pereira, Joana; Pedrosa, Anabela Araújo; Bombas, Teresa; Vilar, Duarte; Vicente, Lisa; Canavarro, Maria Cristina

    2014-01-01

    Introdução: Este estudo pretendeu caracterizar as trajetórias relacionais e reprodutivas conducentes à gravidez na adolescência em Portugal, explorando a existência de especificidades regionais.Material e Métodos: O estudo decorreu entre 2008 e 2013 em 42 serviços de saúde públicos. A amostra, nacionalmente representativa, incluiu 459 grávidas com idades entre os 12 e os 19 anos. Os dados foram obtidos por autorrelato, através de uma ficha de caracterização construída para o efeito.Resultados: Independentemente de terem tido um (59,91%) ou múltiplos parceiros sexuais (40,09%), as adolescentes engravidaram de forma mais frequente numa relação de namoro, utilizando contraceção à data da conceção e tendo identificado a falha contracetiva que esteve na origem da gravidez (39,22%). A nível regional, outras trajetórias surgiram com elevada prevalência, refletindo opções como a decisão de engravidar (Alentejo/Açores), a não utilização de contraceção (Centro/Madeira) ou a sua utilização ineficaz sem que a falha contracetiva fosse identificada (Madeira). As relações de namoro revelaram-se maioritariamente duradouras (> 19 meses), com homens mais velhos (> 4 anos) e fora do sistema de ensino (75,16%); estes resultados foram particularmente expressivos quando a gravidez foi planeada.Discussão: O conhecimento gerado por este estudo reflete a necessidade de investir em abordagens preventivas que atendam às necessidades específicas das jovens de cada região e integrem a população masculina de maior risco.Conclusão: Os nossos resultados podem contribuir para o delineamento de políticas de saúde mais eficazes e para uma atuação multidisciplinar mais informada ao nível da educação sexual e do planeamento familiar nas diferentes regiões do país.

  4. Art and Writing: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Arte y escritura: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  5. Reading: Students' Attitudes and Interests in Fourth, Fifth, and Sixth Grades in Official Portuguese Schools in the USA (A Leitura: Atitudes e Preferencias dos Educandos do 4th, 5th, e 6th Anos de Escolaridade nas Escolas Oficiais Portuguesas nos Estados Unidos da America).

    ERIC Educational Resources Information Center

    Castanho, Maria da Graca Borges

    A study investigated attitudes and preferences concerning reading among fourth-, fifth-, and sixth-grade students in Portuguese-language schools in the United States. Extrinsic factors influencing students (parents, teachers) were also analyzed. The research took place in 10 schools in 5 states. Data were obtained using questionnaires (students)…

  6. A Visit to the Library: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Una visita a la biblioteca: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides suggestions for parents…

  7. A Guide for Parents and Families about What Your 11th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Grado 11 Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  8. Algunas Premisas Metodologicas y Conceptuales sobre el Desarrollo de los Movimientos en el Primer Ano de Vida (0-12 Meses) (Some Methodological and Conceptual Premises about the Development of Movement in the First Year of Life (0-12 Months)).

    ERIC Educational Resources Information Center

    Bequer Diaz, Gladys

    1997-01-01

    Examined the emergence of principal and secondary movements in Cuban children in their first year of life. Based on 35 examples of observed movements, an integrated program of activity is developed to assist in the development of physical skills which are essential to the development of a well-rounded personality. (AS)

  9. Talking, Singing, Rhyming: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Hablar, cantar, recitar: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  10. Exploring with Technology: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Exploremos con tecnologia: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides computer literacy…

  11. Reading with Children: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = La lectura con los ninos: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  12. Words All around Us: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Palabras y palabras a nuestro alrededor: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  13. Art and Writing: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Arte y escritura: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  14. Words All around Us: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Palabras y palabras a nuestro alrededor: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  15. A Visit to the Library: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Una visita a la biblioteca: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides suggestions for parents…

  16. Talking, Singing, Rhyming: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Hablar, cantar, recitar: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  17. Reading with Children: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = La lectura con los ninos: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  18. Algunas Premisas Metodologicas y Conceptuales sobre el Desarrollo de los Movimientos en el Primer Ano de Vida (0-12 Meses) (Some Methodological and Conceptual Premises about the Development of Movement in the First Year of Life (0-12 Months)).

    ERIC Educational Resources Information Center

    Bequer Diaz, Gladys

    1997-01-01

    Examined the emergence of principal and secondary movements in Cuban children in their first year of life. Based on 35 examples of observed movements, an integrated program of activity is developed to assist in the development of physical skills which are essential to the development of a well-rounded personality. (AS)

  19. Exploring with Technology: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Exploremos con tecnologia: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides computer literacy…

  20. ...And That's How It All Began: Putting Information about Your Child's Growth, Health and Safety All within Your Reach...Because the First Years Last Forever! = ...Y asi es como empezo todo: Ponemos a su alcance en forma conjunta la informacion sobre el crecimiento, la salud y la seguridad de su hijo...Porque los primeros anos duran para siempre!

    ERIC Educational Resources Information Center

    North Carolina Partnership for Children, Raleigh.

    Smart Start is North Carolina's model early childhood initiative to help all North Carolina children enter school healthy and prepared for success. This resource guide, in Spanish and English versions, is designed to provide parents with information on infant and child development, health care, and resources for further assistance. Presented in an…

  1. A Guide for Parents and Families about What Your 5th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 5to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  2. A Guide for Parents and Families about What Your 8th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Octavo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  3. A Guide for Parents and Families about What Your 7th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Septimo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  4. A Guide for Parents and Families about What Your 2nd Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 2do Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  5. A Guide for Parents and Families about What Your 3rd Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 3er Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  6. A Guide for Parents and Families about What Your 10th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Decimo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Education Oversight Committee, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  7. A Guide for Parents and Families about What Your 4th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 4to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  8. A Guide for Parents and Families about What Your 6th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 6to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  9. A Guide for Parents and Families about What Your 1st Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 1er Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  10. A Guide for Parents and Families about What Your 9th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Noveno Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  11. A Guide for Parents and Families about What Your Kindergartner Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Jardin Infantil (Kindergarten) Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  12. A Guide for Parents and Families about What Your 12th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Grado 12 Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Education Oversight Committee, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  13. El juego entre el nacimiento y los 7 anos: Un manual para ludotecarias. Investigacion-accion sobre la Familia y la Primera Infancia. UNESCO Sector de Educacion Monografia (Play between Birth and 7 Years: A Manual for Preschool Teachers. Action Research in Family and Early Childhood. UNESCO Education Sector Monograph).

    ERIC Educational Resources Information Center

    Grellet, Carolina

    The purpose of this Spanish-language manual is to help preschool teachers better understand theoretical concepts related to children's play. Following a preface that discusses UNESCO's activities related to early childhood education, the two main sections of the manual discuss children's play between 0-2 years and 2-7 years. Each section includes…

  14. En sus marcas--Listos--A leer! Para los cuidadores de ninos pequenos: Actividades de lenguaje para la primera infancia y ninez entre el nacimiento y los 5 anos. El reto: A leer, America! (Ready--Set--Read! For Caregivers: Early Childhood Language Activities for Children from Birth through Age Five. America Reads Challenge).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This Ready--Set--Read Kit includes an activity guide for caregivers, a 1997-98 early childhood activity calendar, and an early childhood growth chart. The activity guide presents activities and ideas that caregivers (family child care providers and the teachers, staff, and volunteers in child development programs) can use to help young children…

  15. En sus marcas--Listos--A leer! Para las familias: Actividades de lenguaje para la primera infancia y ninez entre el nacimiento y los 5 anos. El reto: A leer, America! (Ready--Set--Read! For Families: Early Childhood Language Activities for Children from Birth through Age Five. America Reads Challenge).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This Ready--Set--Read Kit includes an activity guide for families, a 1997-98 early childhood activity calendar, and an early childhood growth wallchart. The activity guide presents activities and ideas that families (adults who have nurturing relationships with a child--a mother, father, grandparent, other relative, or close friend) can use to…

  16. ...And That's How It All Began: Putting Information about Your Child's Growth, Health and Safety All within Your Reach...Because the First Years Last Forever! = ...Y asi es como empezo todo: Ponemos a su alcance en forma conjunta la informacion sobre el crecimiento, la salud y la seguridad de su hijo...Porque los primeros anos duran para siempre!

    ERIC Educational Resources Information Center

    North Carolina Partnership for Children, Raleigh.

    Smart Start is North Carolina's model early childhood initiative to help all North Carolina children enter school healthy and prepared for success. This resource guide, in Spanish and English versions, is designed to provide parents with information on infant and child development, health care, and resources for further assistance. Presented in an…

  17. Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans.

    PubMed

    Calabrese, Cecilia; Corcione, Nadia; Rea, Gaetano; Stefanelli, Francesco; Meoli, Ilernando; Vatrella, Alessandro

    2016-01-01

    Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting 2 agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance. RESUMO A bronquiolite obliterante pós-infecciosa (BOPI) é uma doença das pequenas vias aéreas caracterizada por limitação fixa do fluxo aéreo. Portanto, os broncodilatadores e os corticosteroides inalatórios não são recomendados como opções de terapia de manutenção. Atualmente, o manejo da BOPI consiste apenas de um acompanhamento rigoroso dos pacientes afetados, visando à prevenção e ao tratamento precoce de infecções pulmonares. A incidência de BOPI tem aumentado na população pediátrica nos últimos anos. Os pacientes com BOPI caracterizam-se por um declínio progressivo da função pulmonar, associado a uma diminuição da capacidade funcional global. Relatamos aqui o caso de um homem relativamente jovem diagnosticado com BOPI, acompanhado por três anos. Ap

  18. Pulmonary Embolism in Ambulatory Oncologic Patients.

    PubMed

    Silva, Patrícia; Rosales, Maria; Milheiro, Maria João; Santos, Luísa L

    2015-01-01

    Introdução: A associação entre a doença oncológica e a doença tromboembólica venosa é conhecida. O doente oncológico apresenta um risco de evento trombótico seis a sete vezes superior à população em geral. O tromboembolismo pulmonar é uma importante causa de morbilidade e mortalidade neste grupo de doentes, encontrando-se a sua prevalência subestimada. Material e Métodos: Estudo retrospetivo de todos os episódios de tromboembolismo pulmonar referenciados num período de cinco anos. Selecionaram-se os doentes oncológicos em regime de ambulatório, tendo sido revistos os dados demográficos, fatores de risco, presença de sintomatologia ao diagnóstico, estratificação de risco de doença tromboembólica venosa pelo modelo de Khorana, probabilidade de mortalidade aos 30 dias e sobrevivência global. O trabalho elaborado está de acordo com a declaração de Helsínquia. Resultados: Avaliaram-se 186 doentes, 55,9% do sexo feminino, mediana de idade de 64 anos. As neoplasias mais prevalentes foram a colo-rectal (24,2%) e a pulmonar (17,7%), sendo que a maioria apresentava metástases (66,1%) ou realizaram quimioterapia (69,4%). O tromboembolismo pulmonar foi um achado imagiológico em 69,4%, sendo que nenhum dado clínico analisado no nosso estudo mostrou ter significado estatístico na apresentação de tromboembolismo pulmonar com sintomatologia clínica evidente. Observou-se uma mortalidade aos 30 dias resultante do tromboembolismo pulmonar de 7,5%, tendo-se verificado que os doentes sintomáticos apresentaram uma sobrevivência média inferior relativamente aos assintomáticos (12 vs. 20 meses; p = 0,029). A aplicação retrospetiva do modelo preditivo de Khorana para doença tromboembólica venosa nos doentes sob quimioterapia permitiu identificar 11% dos indivíduos em alto risco. Discussão: O tromboembolismo pulmonar foi um achado imagiológico na maioria dos doentes, sendo que nenhuma variável clínica se associou à presença ou aus

  19. Playful Interventions Increase Knowledge about Healthy Habits and Cardiovascular Risk Factors in Children: The CARDIOKIDS Randomized Study.

    PubMed

    Cecchetto, Fátima H; Pena, Daniela B; Pellanda, Lucia C

    2017-07-20

    idade entre 7 e 11 anos. Medidas antropométricas foram coletadas, e dois questionários (DAFA, Dia Típico de Atividades Físicas e de Alimentação e o CARDIOKIDS, um questionário de conhecimento sobre fatores de risco cardiovasculares) foram aplicados no basal, ao final da intervenção, e três meses depois. A intervenção consistiu em oito workshops lúdicos, que incluiu a apresentação de uma peça de teatro. Setenta e nove estudantes foram randomizados para o grupo intervenção (n = 40) ou para o grupo controle (n = 39). A idade média foi 10 ± 1,1 anos. Após oito semanas, o grupo intervenção mostrou uma melhora significativa no escore de conhecimento (p < 0,01). Houve um aumento nos escores de atividade física em ambos os grupos, mas sem diferença entre os grupos no final da intervenção (p=0,209). Observou-se uma redução no percentil do IMC no grupo intervenção, mas não houve diferença estatística entre os grupos após a intervenção. Intervenções lúdicas podem melhorar o conhecimento e níveis de atividade física em crianças e, quando combinadas com outras estratégias, podem ser benéficas na prevenção da obesidade e melhoria do autocuidado.

  20. [Fiability Study of Diabetes Empowerment Scale: Short Version].

    PubMed

    Aveiro, Marcelo; Santiago, Luiz Miguel; Ferreira, Pedro Lopes; Simões, José Augusto

    2015-01-01

    Objetivo: Avaliar a correlação entre o valor obtido pelo instrumento de medição Diabetes Empowerment Scale - Short Form e o controlo da pessoa com diabetes medido pelo valor da hemoglobina glicada A1c.Material e Métodos: Estudo observacional transversal pela aplicação do Diabetes Empowerment Scale - Short Form a pessoas com diabetes de três Unidades de Saúde Familiar da Região Centro de Portugal após realização de teste e reteste (primeiro por escrito e, passados cinco minutos, oralmente) para determinação da coerência interna através do valor de alfa de Cronbach em 20 elementos que não foram depois estudados. A aplicação a pacientes diabéticos foi feita após a consulta de enfermagem e antes da entrada na consulta médica. Foi realizada estatística descritiva e inferencial apos verificação da normalidade dos dados.Resultados: Na primeira fase o valor de alfa de Cronbach de 0,90 a 1,00 relativamente aos oito itens da escala. Na aplicação escrita, a média de resultados foi de 3,78 ± 0,71 e na aplicação oral de 3,79 ± 0,65, p = 0,629. A amostra da segunda fase foi de 81 pessoas com diabetes, sendo 55,6% do sexo masculino. A idade média foi de 68,5 ± 1,1 anos com uma HbA1c média de 6,8 ± 0,2 e um tempo de evolução desde o diagnóstico de 9,2 ± 0,9 anos. A média da pontuação final da escala foi de 4,1 ± 0,8. Verificou-se uma correlação significativa entre a pontuação final e os níveis de Hba1C (ÏÅ = -0,114; p = 0,312).Conclusão: A Escala de Capacidade de Controlo da Diabetes âÄì Versão Breve revelou ser uma escala fiável para medir a capacitação em doentes diabéticos em Portugal. Confirmou-se a presença de uma correlação estatisticamente significativa entre o resultado obtido no final da escala e o valor de HbA1c.