Fact Sheets from the ERIC Clearinghouse on Handicapped and Gifted Children, 1980.

ERIC Educational Resources Information Center

ERIC Clearinghouse on Handicapped and Gifted Children, Reston, VA.

The document is a compilation of 15 fact sheets developed during 1980 by the ERIC Clearinghouse on Handicapped and Gifted Children. Fact sheets are single sheets which provide basic information in a question-answer format and include additional resources and references. The fact sheets have the following titles: "Sex Education for Retarded…

Over the counter drugs (and dietary supplement) exercise: a team-based introduction to biochemistry for health professional students.

PubMed

Phadtare, Sangita; Abali, Emine; Brodsky, Barbara

2013-01-01

For successful delivery of basic science topics for health-professional students, it is critical to reduce apprehension and illustrate relevance to clinical settings and everyday life. At the beginning of the Biochemistry course for Physician Assistants, a team-based assignment was designed to develop an understanding of the mechanism of action, effectiveness, and toxicity of five common over the counter (OTC) drugs and dietary supplements, and place these familiar medicines in a political and historical context. The objectives of this exercise were to stimulate interest in biochemistry; to provide basic information on enzymes and enzyme inhibitors related to these drugs to be expanded upon later in the course; and to encourage active and interactive learning. Teams of five students were formed, and each student was given an information sheet on aspirin, alpha-galactosidase, orlistat, dextromethorphan, or simvastatin, a low dose statin, which was previously available without prescription at pharmacies in the UK. After each member of the team acquired information on one OTC drug/dietary supplement by reading an assigned information sheet, the team was asked to go through a series of questions, and then submit answers to a quiz as a group. A high rate of success on the quiz, an overwhelmingly positive response on formal course evaluations, and enthusiastic exchanges during class suggested this team-based session accomplished its goals. Copyright © 2013 Wiley-Liss, Inc.

Food Service Management. Second Edition. Answer Book/Teacher's Guide. Second Edition.

ERIC Educational Resources Information Center

Hatchett, Melvin S.; Zelade, Richard

This document contains a student assignment book with 22 assignments for a course in food service management and a teacher's guide with answers to the assignments and tips on presenting the lessons to which they pertain. The assignments cover the following topics: career opportunities; entering the food service industry; classifications of…

HOW TO PASS ARMED FORCES TESTS.

ERIC Educational Resources Information Center

Cowles Education Corp., New York, NY.

FOLLOWING THE CONTENT OF THE ARMED FORCES EXAMINATIONS, THIS BOOK IS PROGRAMED WITH STEP-BY-STEP DIRECTIONS, TESTS, AND CORRECT ANSWERS AND SOLUTIONS. THE CANDIDATE CAN SIMULATE TAKING THE ACTUAL EXAMS BY ANSWERING THE AUTHENTIC QUESTIONS AND PROBLEMS, MARKING THE ANSWER SHEET, AND EVALUATING HIS OWN APTITUDE BY COMPARING HIS ANSWERS WITH THE…

Merchandise Display, a Distributive Education Manual and Answer Book.

ERIC Educational Resources Information Center

Hatchett, Melvin S.

This revised manual in basic merchandise display for trainees in distributive education, together with a separate answer key, contains 23 self-study assignments, each with training objectives, questions to answer, and student projects. Developed by a distributive education coordinator, these assignments cover a wide range of topics, from the…

Drafting. Competency Based Curriculum.

ERIC Educational Resources Information Center

Everly, Al; And Others

This competency based drafting curriculum is presented in seven specialization sections with units in each section containing a competency statement, performance objective, learning activities, evaluation, and quiz or problem sheets. Some units also contain answer sheets and/or handout sheets. Sections and number of units presented are (1) basic…

A pilot study of simple interventions to improve informed consent in clinical research: feasibility, approach, and results.

PubMed

Kass, Nancy E; Taylor, Holly A; Ali, Joseph; Hallez, Kristina; Chaisson, Lelia

2015-02-01

Research suggests that participants do not always adequately understand studies. While some consent interventions increase understanding, methodologic challenges have been raised in studying consent outside of actual trial settings. This study examined the feasibility of testing two consent interventions in actual studies and measured effectiveness of interventions in improving understanding. Participants enrolling in any of eight ongoing clinical trials were sequentially assigned to one of three different informed consent strategies for enrollment in their clinical trial. Control participants received standard consent procedures for their trial. Participants in the first intervention arm received a bulleted fact sheet summarizing key study information. Participants in the second intervention arm received the bulleted fact sheet and also engaged in a feedback Q&A session. Later, patients answered closed- and open-ended questions to assess patient understanding and literacy. Descriptive statistics, Wilcoxon -Mann -Whitney and Kruskal-Wallis tests were generated to assess correlations; regression analysis determined predictors of understanding. 144 participants enrolled. Using regression analysis, participants receiving the second intervention scored 7.6 percentage points higher (p = .02) on open-ended questions about understanding than participants in the control, although unadjusted comparisons did not reach statistical significance. Our study supports the hypothesis that patients receiving both bulleted fact sheets and a Q&A session had higher understanding compared to standard consent. Fact sheets and short structured dialog are quick to administer and easy to replicate across studies and should be tested in larger samples. © The Author(s) 2014.

Fact Sheet - Final Amendments to Air Toxics Rule for Miscellaneous Coating Manufacturing

EPA Pesticide Factsheets

Fact sheet answering questions concerning National Emission Standards for Hazardous Air Pollutants for Miscellaneous Coating Manufacturing which includes facilities that produce inks, paints and adhesives.

Continuing Education- "The Action Level"®.

PubMed

Pierce, J Thomas

2005-03-01

Access "The Action Level"® Questions online at: http://www.acgih.org/products/joeh/alquestions.htm Access "The Action Level"® Answers online at: http://www.acgih.org/products/joeh/alanswers.htm Access "The Action Level"® Registration Form online at: https://www.acgih.org/products/joeh/alregfrm.htm "The Action Level,"® a self-study, continuing education program, provides a convenient and interesting opportunity for individuals to expand their knowledge in relevant areas of industrial hygiene, as well as occupational and environmental safety and health. The program is approved by both the American Board of Industrial Hygiene, and the Board of Certified Safety Professionals, which award Certification Maintenance (CM) points and Continuance of Certification (COC) points, respectively, for successful participation. Participants must read each issue of the Journal, answer "The Action Level"® questions, and return the completed answer sheet at the end of that issue's "The Action Level"® column. To earn the designated CM or COC credit, a score of 70 percent or better is required within a 12-month period. Certified Industrial Hygienists and Certified Associate Industrial Hygienists may earn 2 points per year. Certified Safety Professionals may earn 1.2 points per year. Enrollment is possible each month, but points are awarded only four times each year-in March, June, September, and December-to participants who score an average of 70 percent or better within each threemonth period. For example, if you register in December 2004, you will receive 0.5 CM points and/or 0.3 COC points for your January, February, and March 2005 responses (assuming that you submitted all answer sheets and scored a 70 percent or better average on them; only in your first quarter of enrollment will you be permitted to submit answer sheets for two months and receive full credit; three answer sheets are required for all other quarters). Further, you'll receive 0.5 CM points or 0.3 COC points after satisfactorily completing the April, May, and June 2005 issues, and so on. To enroll, complete the registration form and the answer sheet at the end of this "The Action Level"® column. The cost is $179 (ACGIH®/AIHA members)/$199 (nonmembers) for one year. Nonmembers are encouraged to become members to take advantage of the 10-percent member discount. For more information regarding ACGIH® membership, call 513-742-2020, or apply online at http://www.acgih.org/members/memberform.htm . Checks must be in U.S. currency, drawn on a U.S. bank, and payable to ACGIH®. We also accept AmEx, MasterCard, Discover, and Visa. This continuing education program fee is separate from the Journal subscription cost. The fee covers administration costs, and is nonrefundable. Submissions must be received by the date listed on each answer sheet.

Fact Sheets and Questions and Answers for the Final Air Toxics Rules for the Aerospace Manufacturing and Rework Industry

EPA Pesticide Factsheets

This page contains the July 1995 final rule fact sheet and the January 2015 proposed rule fact sheet that contains information on the National Emission Standards for Aerospace Manufacturing and Rework Facilities, as well as a 2001 Q&A document on the rule

Unit: Minerals and Crystals, First Trial Materials, Inspection Set.

ERIC Educational Resources Information Center

Australian Science Education Project, Toorak, Victoria.

This unit, one of a series being developed for Australian secondary school science courses, consists of a teacher's guide, two student booklets, a test booklet, and a student workbook which also contains answers to questions raised in the student booklets, and a answer sheet containing comments on the answers to the questions in the test booklet.…

Fact Sheets: Final Air Toxics Rules for Ethylene Oxide Emissions from Commercial Sterilization and Fumigation Operations

EPA Pesticide Factsheets

This page contains November 1994 and November 1999 fact sheets with information regarding the Final Ethylene Oxide Emissions Standards for Sterilization Facilities. These documents contain answers to common questions for this NESHAP

Advertising, a Distributive Education Manual and Answer Book.

ERIC Educational Resources Information Center

Martin, Charles H.; Cyrus, Cinda L.

This revised manual for individualized instruction of distributive education trainees at the high school or junior college level in basic advertising and sales promotion activities includes 15 self-study assignments, teaching suggestions, and a bibliography. Together with a separate answer key, each assignment provides student questions and…

Facts for Feeding Series.

ERIC Educational Resources Information Center

Academy for Educational Development, Washington, DC.

This document compiles several fact sheets, in multiple languages, for mothers and parent educators providing information and answering questions concerning breastfeeding infants. The fact sheets are published in English, French, and Spanish, and cover the following topics: (1) "Recommended Practices To Improve Infant Nutrition during the…

A Pilot Study of Simple Interventions to Improve Informed Consent in Clinical Research: Feasibility, Approach, and Results

PubMed Central

Kass, Nancy; Taylor, Holly; Ali, Joseph; Hallez, Kristina; Chaisson, Lelia

2014-01-01

Background Informed consent is intended to ensure that individuals understand the purpose, risks, and benefits of research studies, and then can decide, voluntarily, whether to enroll. However, research suggests that consent procedures do not always lead to adequate participant understanding and may be longer and more complex than necessary. Studies also suggest some consent interventions, including enhanced consent forms and extended discussions with patients, increase understanding, yet methodologic challenges have been raised in studying consent in actual trial settings. This study aimed to examine the feasibility of testing two consent interventions in actual studies and also to measure effectiveness of interventions in improving understanding of trials. Methods Participants enrolling in any of eight ongoing clinical trials (“collaborating studies”) were, for the purposes of this study, sequentially assigned to one of three study arms involving different informed consent procedures (one control and two intervention). Control participants received standard consent form and processes. Participants in the 1st intervention arm received a bulleted fact-sheet providing simple summaries of all study components in addition to the standard consent form. Participants in the 2nd intervention arm received the bulleted fact-sheet and standard consent materials and then also engaged with a member of the collaborating study staff in a feedback Q&A session. Following consent procedures, we administered closed and open ended questions to assess patient understanding and we assessed literacy level. Descriptive statistics, Wilcoxon-Mann-Whitney and Kruskal-Wallis tests were generated to assess correlations; regression analysis determined predictors of patient understanding. Results 144 participants enrolled. Using regression analysis participants receiving the 2nd intervention, which included a standard consent form, bulleted fact sheet and structured question and answer session with a study staff member, had open-ended question scores that were 7.6 percentage points higher (p=.02) than participants who received the control arm (standard consent only), although unadjusted comparisons did not reach statistical significance. Eleven clinical trial investigators agreed to participate and 8 trials provided sufficient data to be included, thereby demonstrating feasibility of consent research in actual settings. Conclusions Our study supports the hypothesis that patients receiving both bulleted fact sheets and a question and answer session have higher understanding compared to patients receiving standard consent form and procedures alone. Fact sheets and short structured dialog are quick to administer and easy to replicate across studies and should be tested in larger samples for effectiveness. PMID:25475879

Questions & Answers about...Marfan Syndrome.

ERIC Educational Resources Information Center

National Inst. of Arthritis and Musculoskeletal and Skin Diseases (NIH), Bethesda, MD.

This fact sheet answers general questions about Marfan syndrome, a heritable condition that affects the connective tissue. It describes the characteristics of the disorder, the diagnostic process, and ways to manage symptoms. Characteristics include: (1) people with Marfan syndrome are typically very tall, slender, and loose jointed; (2) more than…

Food Marketing: Cashier-Checker. Teacher's Guide. Competency Based Curriculum.

ERIC Educational Resources Information Center

Froelich, Larry; And Others

This teacher's guide is designed to accompany the Competency Based Cashier-Checker Curriculum student materials--see note. Contents include a listing of reference materials, tool and equipment lists, copy of the table of contents for student competency sheets, teacher's suggestions, and answer keys for information sheets and exercises.…

Food Stamps. Learning Packet No. 2.

ERIC Educational Resources Information Center

American Bar Association, Washington, DC. Clearinghouse for Offender Literacy Programs.

This package of instructional materials is designed to aid adults in prison to perform the functional skill of applying for food stamps. The materials consist of instructions for teachers, a sample application for food stamps, a student's work sheet and answer sheet, vocabulary flash cards, and resource materials on food stamps. (MKM)

The development of children's ability to fill the gaps in their knowledge by consulting experts.

PubMed

Aguiar, Naomi R; Stoess, Caryn J; Taylor, Marjorie

2012-01-01

This research investigated children's ability to recognize gaps in their knowledge and seek missing information from appropriate informants. In Experiment 1, forty-five 4- and 5-year-olds were adept in assigning questions from 3 domains (medicine, firefighting, and farming) to corresponding experts (doctor, firefighter, or farmer). However, when given the options of answering the same questions themselves or assigning them to an expert (Experiment 2), only 6-year-olds were consistently able to recognize when they did not know answers and then assign test questions correctly. Four- and 5-year-olds tended to overestimate their own knowledge or assign questions to the wrong expert. This result was replicated in Experiment 3, in which 5-year-olds were given incentives for correct answers. © 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.

Automated grading of homework assignments and tests in introductory and intermediate statistics courses using active server pages.

PubMed

Stockburger, D W

1999-05-01

Active server pages permit a software developer to customize the Web experience for users by inserting server-side script and database access into Web pages. This paper describes applications of these techniques and provides a primer on the use of these methods. Applications include a system that generates and grades individualized homework assignments and tests for statistics students. The student accesses the system as a Web page, prints out the assignment, does the assignment, and enters the answers on the Web page. The server, running on NT Server 4.0, grades the assignment, updates the grade book (on a database), and returns the answer key to the student.

BOOK REVIEW: Key Science Physics: New Edition and Key Science Physics for International Schools: Extension File

NASA Astrophysics Data System (ADS)

Maybank, Maureen

1999-09-01

When handling , I recalled how one set of sixth-form students that I taught affectionately referred to Jim Breithaupt's large format book Understanding Physics for Advanced Level as `Big Jim'. This package, for GCSE students and teachers, is its younger brother. Key Science Physics was reviewed in this journal over four years ago. Now it is in a new edition with an expanded ring file of teacher resources (a Teacher's Guide and Extension File). It has been expanded for a wider range of students to meet the requirements of all GCSE syllabuses with additional topics for IGCSE and IB. The international bit seems to be among materials in the file of resources and does not appear in the title of the students' textbook. This is not one of those purchases that will only get occasional use and be left in a department library but it is one that contains sufficient excellent material to become central to any GCSE Physics course. For the students there is a single-volume 396-page textbook in full colour (not a heavyweight book). Marginal comments point out places where an Activity or Assignment from the Extension File fits in. All the materials in the teacher's Extension File are cross referenced to the numbering of this textbook, i.e. its Themes, Topics, Checkpoints, Tests etc, not to page numbers. The margin is used in other attractive ways to highlight a summary, propose a first thought or provide a topic summary. The text is fruitful mix of pure physics, applications and personalities. To support the students' practical work the Extension File contains photocopiable sheets. For the activities and assignments a few contain a harder version to give access to the higher levels of attainment. Four alternatives to practical questions are given; there are also exam questions and multiple choice questions for each topic. These all have helpful mark schemes on the teacher's answers pages. What else do you get? A Glossary collection of sheets to photocopy with space to enter a definition in a second language. Versions of many key diagrams in the student book are enlarged and reworked in clear black and white to make OHP transparencies. There is a mention of these also being in colour on a CD-ROM. The organization of the Extension File is as clear as is reasonably possible. As a user, I would add coloured page dividers to mark the sections within it. The Teacher's Guide is admirable in its restraint - just 26 sides of topic notes - which includes the answers to the non-numerical checkpoint questions missing in the student book. It is not wordy or full of educational theory but succinct and relevant to the day-to-day business of learning with these materials. Reading it, I was aware of the snags that a novice teacher might be glad to know but were missing. As always, materials like these should come with a health warning - try out all homework sheets, instructions for activities and assignments before your students!

Influence of Self-generated Anchors on the Voice Handicap Index-10 (VHI-10).

PubMed

Canals-Fortuny, Elisabet; Vila-Rovira, Josep

2017-03-01

The aim of this research is to study whether the presentation of the Voice Handicap Index-10 questionnaire administered at the beginning of the treatment impinged on the results of the responses from the end of the treatment. The questionnaire was administered at the beginning of the treatment to a total of 308 patients. After the treatment, a group of 235 patients answered the questionnaire again without any reference to their responses on the initial administration. The other group of participants, consisting of 73 subjects, completed the questionnaire with the answer sheet of their initial self-assessment in sight. The data obtained show that patients who responded to the anchored answer test show less dispersion and a smaller coefficient of variation (0.90) than those who responded to the nonanchored answer test (coefficient of variation = 1.66). The method of administration of the Voice Handicap Index-10 at the end of a treatment influences the dispersion of the results. We recommend that the patient be anchored to the initial answer sheet while responding to the final self-assessment. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Comprehensive Small Engine Repair.

ERIC Educational Resources Information Center

Hires, Bill; And Others

This curriculum guide contains the basic information needed to repair all two- and four-stroke cycle engines. The curriculum covers four areas, each consisting of one or more units of instruction that include performance objectives, suggested activities for teacher and students, information sheets, assignment sheets, job sheets, visual aids,…

14 CFR Sec. 1-4 - System of accounts coding.

Code of Federal Regulations, 2010 CFR

2010-01-01

... General Accounting Provisions Sec. 1-4 System of accounts coding. (a) A four digit control number is assigned for each balance sheet and profit and loss account. Each balance sheet account is numbered sequentially, within blocks, designating basic balance sheet classifications. The first two digits of the four...

Temperature, Pulse, and Respiration. Instructor's Packet. Learning Activity Package.

ERIC Educational Resources Information Center

Runge, Lillian

This instructor's packet accompanies the learning activity package (LAP) on temperature, pulse, and respiration. Contents included in the packet are a time sheet, suggested uses for the LAP, an instruction sheet, final LAP reviews, a final LAP review answer key, suggested activities, an additional resources list, and student completion cards to…

sup 1 H assignments and secondary structure determination of the soybean trypsin/chymotrypsin Bowman-Birk inhibitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Werner, M.H.; Wemmer, D.E.

1991-04-09

The {sup 1}H resonance assignments and secondary structure of the trypsin/chymotrypsin Bowman-Birk inhibitor from soybeans were determined by nuclear magnetic resonance spectroscopy (NMR) at 600 MHz in an 18% acetonitrile-d{sub 3}/aqueous cosolvent. Resonances from 69 to 71 amino acids were assigned sequence specifically. Residues Q11-T15 form an antiparallel {beta}-sheet with residues Q21-S25 in the tryptic inhibitory domain and an analogous region of antiparallel sheet forms between residues S38-A42 and Q48-V52 in the chymotryptic inhibitory domain. The inhibitory sites of each fragment (K16-S17 for trypsin, L43-S44 for chymotrypsin) are each part of a type VI like turn at one end ofmore » their respective region of the antiparallel {beta}-sheet. These structural elements are compared to those found in other Bowman-Birk inhibitors.« less

ACER Chemistry Test Item Collection. ACER Chemtic Year 12.

ERIC Educational Resources Information Center

Australian Council for Educational Research, Hawthorn.

The chemistry test item banks contains 225 multiple-choice questions suitable for diagnostic and achievement testing; a three-page teacher's guide; answer key with item facilities; an answer sheet; and a 45-item sample achievement test. Although written for the new grade 12 chemistry course in Victoria, Australia, the items are widely applicable.…

Phenylketonuria (PKU). ARC Q&A #101-53.

ERIC Educational Resources Information Center

Arc, Arlington, TX.

This fact sheet uses a question-and-answer format to summarize what is known about phenylketonuria (PKU), an inherited metabolic disease that leads to mental retardation and other developmental disabilities if untreated in infancy. Questions and answers address the following topics: what PKU is; how PKU is inherited; the diagnosis of PKU; the…

HIV/AIDS and Pediatric AIDS. The Arc Q & A.

ERIC Educational Resources Information Center

Kowalski, Jo Anne T.

This fact sheet uses a question-and-answer format to summarize what is known about HIV/AIDS (Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome) and pediatric AIDS and applies this information to children in school settings. Questions and answers address the following topics: what the AIDS disease and HIV infection are; estimates…

A Module for Hospital Central Processing Technicians on Decontamination, Assembly and Wrapping Concepts of GYN Hysterectomy Instruments.

ERIC Educational Resources Information Center

Wojcik, Roseann B.; Moseley, James L.

This learning module can be used as an orientation guide, inservice tool, or resource guide for hospital central processing department technicians and instructors. It contains information sheets, worksheets, worksheet answers, a posttest, and posttest answers on correct procedures for decontaminating, assembling, and wrapping the medical…

The Influence of a Response Format Test Accommodation for College Students with and without Disabilities

ERIC Educational Resources Information Center

Potter, Kyle; Lewandowski, Lawrence; Spenceley, Laura

2016-01-01

Standardised and other multiple-choice examinations often require the use of an answer sheet with fill-in bubbles (i.e. "bubble" or Scantron sheet). Students with disabilities causing impairments in attention, learning and/or visual-motor skill may have difficulties with multiple-choice examinations that employ such a response style.…

Fuels planning: science synthesis and integration; economic uses fact sheet 06: selection criteria analysis

Treesearch

Rocky Mountain Research Station USDA Forest Service

2004-01-01

Confidence in decisionmaking can often come from knowing if others in similar circumstances would choose the same management strategy. Researchers at the USDA FS Pacific Northwest Research Station and the University of Saskatchewan have developed a Selection Criteria Analysis for answering this very question. This fact sheet discusses factors affecting the choice of...

Human Trafficking of Children in the United States: A Fact Sheet

ERIC Educational Resources Information Center

US Department of Education, 2007

2007-01-01

This fact sheet presents questions and answers related to the human trafficking of children in the United States. It describes human trafficking and its extent in the United States, how human traffickers target children for coerced labor and sex exploitation, how to identify victims of human trafficking, how to report a suspected incidence of…

Case Management for Individuals with Mental Retardation. ARC Facts.

ERIC Educational Resources Information Center

Association for Retarded Citizens, Arlington, TX.

A question-and-answer format is used in this fact sheet to provide information on case management for individuals with mental retardation. The fact sheet describes the major components of a case management system, the role of the case manager, the individual's or family's role in case management, providers of case management services and systems…

Prevention of Neural Tube Defects. ARC Q&A #101-45.

ERIC Educational Resources Information Center

Arc, Arlington, TX.

This fact sheet uses a question-and-answer format to summarize issues related to the prevention of neural tube defects. Questions and answers address the following topics: what neural tube defects are and the most common types (spina bifida and anencephaly); occurrence of neural tube defects during the first month of pregnancy; the frequency of…

Retailing. Instructor's Guide Sheets and Instructor's Package, Modules R 1-45. Competency-Based Education.

ERIC Educational Resources Information Center

Kentucky State Dept. of Education, Frankfort.

This package contains instructor's guide sheets and student task assignment sheets for Modules R 1-45 of the competency-based curriculum in retailing developed for use in secondary and postsecondary schools in Kentucky. Some of the topics covered in the modules include the following: retailing--past, present, and future; retailing occupations;…

76 FR 47550 - Certain Tissue Paper Products From the People's Republic of China: Notice of Rescission of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... products produced from Chinese-origin jumbo rolls/ sheets.\\3\\ We determined in the Preliminary Results, as... paper products produced using Chinese-origin jumbo rolls/sheets. Further, based on AFA, we preliminarily... produced by MFVN from Chinese-origin jumbo rolls/sheets is China. Consequently, we assigned MFVN a cash...

Nutrition: Eating for Better Health. Student Workbook. Health Promotion for Adult Literacy Students: An Empowering Approach.

ERIC Educational Resources Information Center

Hudson River Center for Program Development, Glenmont, NY.

This workbook was developed to help adult literacy students learn about nutrition. It contains information sheets, student worksheets, and answers to the worksheets. The information sheets are coordinated with an available audiotape. Some of the topics covered in the workbook are the following: choosing good foods without spending a lot of money;…

Related Instructional Material for Electrical Apprentice Technical Training. Student Worksheets. Series C (Third Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Information sheets and student worksheets for twenty-five lesson plans designed for a third-year electrical apprentice technical training program are presented in this workbook. The information sheets provide summary information about the lesson topics and the worksheets contain problems to be solved and questions to be answered relating to each…

Related Instructional Material for Electrical Apprentice Technical Training. Student Worksheets. Series D (Fourth Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Information sheets and student worksheets for twenty-seven lesson plans designed for a fourth-year electrical apprentice technical training program are presented in this workbook. The information sheets provide summary information about the lesson topics and the worksheets contain problems to be solved and questions to be answered relating to each…

First Aid: Helping Yourself, Helping Others. Student Workbook. Health Promotion for Adult Literacy Students: An Empowering Approach.

ERIC Educational Resources Information Center

Hudson River Center for Program Development, Glenmont, NY.

This workbook was developed to help adult literacy students learn about first aid in order to help themselves and others. It contains information sheets, student worksheets, and answers to the worksheets. The information sheets are coordinated with an available audiotape. Some of the topics covered in the workbook are the following: handling an…

Managed Care and Long-Term Services for People with Mental Retardation. ARC Q&A.

ERIC Educational Resources Information Center

Arc, Arlington, TX.

This fact sheet uses a question-and-answer format to summarize issues related to managed care and long-term services for people with mental retardation. Questions and answers address the following topics: the evolving concept of "managed care"; the application of managed care to provide cost-efficient long-term services for people with mental…

The MDT Innovation: Machine-Scoring of Fill-in-the-Blank Tests.

ERIC Educational Resources Information Center

Anderson, Paul S.

The Multi-Digit Technologies (MDT) testing technique is discussed as the first major advance in computer assisted testing in several decades. The MDT testing method uses fill-in-the-blank or completion-type questions, with an alphabetized long list of possible responses. An MDT answer sheet is used to record the code number of the answer. For…

Preventing Mental Retardation through Use of Bicycle Helmets. ARC Q&A #101-48.

ERIC Educational Resources Information Center

Arc, Arlington, TX.

This fact sheet uses a question-and-answer format to summarize what is known about preventing mental retardation through use of bicycle helmets. Questions and answers address the following topics: the importance of bicycle helmets; the number of bike riders injured or killed each year in bicycle crashes (about 1,000 killed, over 500,000 people…

People with Mental Retardation in the Criminal Justice System. ARC Q&A #101-47.

ERIC Educational Resources Information Center

Reynolds, Leigh Ann

This fact sheet uses a question-and-answer format to summarize issues related to people with mental retardation in the criminal justice system. Questions and answers address the following topics: the number of people with mental retardation in the criminal justice system (2 to 10 percent of the prison population is mentally retarded); whether…

Structure and luminescence properties of 10-BN sheets

NASA Astrophysics Data System (ADS)

Han, Wei-Qiang; Liu, Lijia; Sham, T. K.; Liu, Zhenxian

2012-10-01

Isotopic 10BN sheets were first prepared using graphene sheets as templates to react with 10B2O3. The edge-areas of BN sheets have much higher oxygen-doping ratios compared to other areas. The emission peak of X-ray excited optical luminescence spectra of the 10BN-sheets is broader and red-shifted because of the isotopic effect. A broad violet-blue emission at a wavelength centered at ~400 nm is assigned to the defect emission due to oxygen-doping and defects in the BN network.

Continuing Education- "The Action Level"®.

PubMed

Pierce, J Thomas

2010-03-01

Access "The Action Level,"® Questions online at: http://www.acgih.org/products/joeh/alquestions.htm Access "The Action Level,"® Answers online at: http://www.acgih.org/products/joeh/alanswers.htm Access "The Action Level,"® Registration Form online at: http://www.acgih.org/products/joeh/alregfrm.htm "The Action Level,"® a self-study, continuing education program, provides a convenient and interesting opportunity for individuals to expand their knowledge in relevant areas of industrial hygiene, as well as occupational and environmental safety and health. The program is approved by both the American Board of Industrial Hygiene, and the Board of Certified Safety Professionals, which award Certification Maintenance (CM) points and Continuance of Certification (COC) points, respectively, for successful participation. Participants must read each issue of the Journal, answer "The Action Level"® questions, and return the completed answer sheet at the end of that issue's "The Action Level"® column. To earn the designated CM or COC credit, a score of 70 percent or better is required within a 12-month period. Certified Industrial Hygienists and Certified Associate Industrial Hygienists may earn 2 points per year. Certified Safety Professionals may earn 1.2 points per year. Enrollment is possible each month, but points are awarded only four times each year-in March, June, September, and December-to participants who score an average of 70 percent or better within each three-month period. If you register in March 2010, you will not receive CM points and/or COC points until the following quarter. In the next quarter, you'll receive 0.5 CM points and/or 0.3 COC points after satisfactorily completing answer sheets for the April, May, and June 2010 issues, and so on. To enroll, complete the registration form and the answer sheet at the end of this "The Action Level"® column. The cost is $199 (ACGIH®/AIHA members)/$219 (nonmembers) for one year. Nonmembers are encouraged to become members to take advantage of the member discount. For more information regarding ACGIH® membership, call 513-742-2020, or apply on-line at http://www.acgih.org/members/memberform.htm . Checks must be in U.S. currency, drawn on a U.S. bank, and payable to ACGIH®. We also accept AmEx, MasterCard, Discover, and VISA. This continuing education program fee is separate from the Journal subscription cost. The fee covers administration costs and is nonrefundable. Submissions must be received by the date listed on each answer sheet.

Related Instructional Material for Electrical Apprentice Technical Training. Student Worksheets. Series No. A (First Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Information sheets and student worksheets for thirty-six lessons designed for a first-year electrical apprentice technical training program are presented in this workbook. The information sheets provide summary information about the lesson topics and the worksheets contain problems to be solved and questions to be answered relating to each lesson.…

Related Instructional Material for Electrical Apprentice Technical Training. Student Worksheets. Series No. B (Second Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Information sheets and student worksheets for twenty-eight lesson plans designed for a second-year electrical apprentice technical training program are presented in this workbook. The information sheets provide summary information about the lesson topics and the worksheets contain problems to be solved and questions to be answered relating to each…

Warning Signs of Youth Violence. Just the Facts: Answers to Your Questions about Psychological Health

ERIC Educational Resources Information Center

American Psychological Association (APA), 2002

2002-01-01

Violence. It's the act of purposefully hurting someone. And it's a major issue facing today's young adults. This fact sheet answers questions that those aged 12-24 might ask about violence. This age group faces the highest risk of being the victim of violence. Questions regard the causes of youth violence, warning signs, what to do if someone…

Multiple-Choice and Short-Answer Exam Performance in a College Classroom

ERIC Educational Resources Information Center

Funk, Steven C.; Dickson, K. Laurie

2011-01-01

The authors experimentally investigated the effects of multiple-choice and short-answer format exam items on exam performance in a college classroom. They randomly assigned 50 students to take a 10-item short-answer pretest or posttest on two 50-item multiple-choice exams in an introduction to personality course. Students performed significantly…

The Effect of Randomized Homework Contingencies on College Students' Daily Homework and Unit Exam Performance

ERIC Educational Resources Information Center

Galyon, Charles E.; Voils, Kyle L.; Blondin, Carolyn A.; Williams, Robert L.

2015-01-01

Students in an introductory educational psychology course submitted answers to daily homework questions for which they received credit either for percentage of questions answered in every homework assignment or for the accuracy of their answers to 10% of randomly selected questions. Potential credit was the same under both homework contingencies,…

Violations of Information Structure: An Electrophysiological Study of Answers to Wh-Questions

ERIC Educational Resources Information Center

Cowles, H. W.; Kluender, Robert; Kutas, Marta; Polinsky, Maria

2007-01-01

This study investigates brain responses to violations of information structure in wh-question-answer pairs, with particular emphasis on violations of focus assignment in it-clefts (It was the queen that silenced the banker). Two types of ERP responses in answers to wh-questions were found. First, all words in the focus-marking (cleft) position…

KIND Reproducibles.

ERIC Educational Resources Information Center

KIND Teacher, 1990

1990-01-01

Presented are 14 student worksheets for use in teaching about environmental conservation. Topics of these games, puzzles include pollution, rainforests, endangered species, habitat destruction, and solid waste. An answer sheet for teachers is included. (CW)

Performance-based readability testing of participant information for a Phase 3 IVF trial

PubMed Central

Knapp, Peter; Raynor, DK; Silcock, Jonathan; Parkinson, Brian

2009-01-01

Background Studies suggest that the process of patient consent to clinical trials is sub-optimal. Participant information sheets are important but can be technical and lengthy documents. Performance-based readability testing is an established means of assessing patient information, and this study aimed to test its application to participant information for a Phase 3 trial. Methods An independent groups design was used to study the User Testing performance of the participant information sheet from the Phase 3 'Poor Responders' trial of In Vitro Fertilisation (IVF). 20 members of the public were asked to read it, then find and demonstrate understanding of 21 key aspects of the trial. The participant information sheet was then re-written and re-designed, and tested on 20 members of the public, using the same 21 item questionnaire. Results The original participant information sheet performed well in some places. Participants could not find some answers and some of the found information was not understood. In total there were 30 instances of information being not found or not understood. Answers to three questions were found but not understood by many of the participants, these related to aspects of the drug timing, Follicle Stimulating Hormone and compensation. Only two of the 20 participants could find and show understanding of all question items when using the original sheet. The revised sheet performed generally better, with 17 instances of information being not found or not understood, although the number of 'not found' items increased. Half of the 20 participants could find and show understanding of all question items when using the revised sheet. When asked to compare the versions of the sheet, almost all participants preferred the revised version. Conclusion The original participant information sheet may not have enabled patients fully to give valid consent. Participants seeing the revised sheet were better able to understand the trial. Those who write information for trial participants should take account of good practice in information design. Performance-based User Testing may be a useful method to indicate strengths and weaknesses in trial information. PMID:19723335

The Origins of the Standards Movement in the United States: Adoption of the Written Test and Its Influence on Class Work

ERIC Educational Resources Information Center

Miyamoto, Kenichiro

2008-01-01

Every state in the United States, under the NCLB act, has set state standards and is testing all students in grades 3-8. Students are given printed questions to which they write answers with a pencil on an answer sheet. These written tests are usually given to determine the academic achievements of students. This paper traces the early history of…

Pre-service teachers’ challenges in presenting mathematical problems

NASA Astrophysics Data System (ADS)

Desfitri, R.

2018-01-01

The purpose of this study was to analyzed how pre-service teachers prepare and assigned tasks or assignments in teaching practice situations. This study was also intended to discuss about kind of tasks or assignments they gave to students. Participants of this study were 15 selected pre-service mathematics teachers from mathematics education department who took part on microteaching class as part of teaching preparation program. Based on data obtained, it was occasionally found that there were hidden errors on questions or tasks assigned by pre-service teachers which might lead their students not to be able to reach a logical or correct answer. Although some answers might seem to be true, they were illogical or unfavourable. It is strongly recommended that pre-service teachers be more careful when posing mathematical problems so that students do not misunderstand the problems or the concepts, since both teachers and students were sometimes unaware of errors in problems being worked on.

Teaching transcultural nursing through literature.

PubMed

Halloran, Laurel

2009-09-01

One of the biggest challenges in nursing education is to develop culturally sensitive graduates. Although theory and lecture are appropriate to introduce cultural issues, the application of those skills is limited by the kinds of clinical experiences and patient populations students may treat. Literary works are a rich source of information for nursing. This assignment was created to sensitize the students to the influence of cultural diversity. Students were assigned to read one novel from an approved list and answer the questions posed on the Cultural Discovery worksheet. The only direction that was given regarding novel selection was that the novel had to represent a culture other than the student's own. The focus was to expose students to a different culture. Classroom discussion, based on worksheet answers, followed. The assignment's good, bad, and ugly outcomes are discussed. Suggestions for adaptation of this assignment to an online format are also provided.

KIND Reproducibles.

ERIC Educational Resources Information Center

KIND Teacher, 1990

1990-01-01

Presented are 14 student worksheets for use in teaching the care of and humane treatment of animals. Topics of these games and puzzles include state animal trivia, domestic pets and wild animals. An answer sheet for teachers is included. (CW)

The First Annual West Antarctic Ice Sheet (WAIS) Science Workshop

NASA Technical Reports Server (NTRS)

Bindschadler, Robert A. (Editor)

1993-01-01

A compilation of abstracts presented at the workshop are presented. The goal was to answer the question, what is the future behavior and potential for rapid collapse of the West Antarctic Ice Sheet (WAIS)? The workshop was organized into four sessions corresponding to the four objectives identified as necessary to reach the WAIS workshop goal: history, current behavior, internal dynamics, and environmental interactions. Presentations were organized by their relevance to each objective, rather than by discipline.

Writing by Number: Teaching Students to Read the Balance Sheet.

ERIC Educational Resources Information Center

Cross, Mary

1990-01-01

Describes an assignment in which students write a short memo report analyzing and comparing both what a company says in its annual report and what its balance sheet shows. Describes four simple mathematical formulas students can use to quickly diagnose a company's financial health. Appends a sample of the short report format. (RS)

My Favorite Assignment.

ERIC Educational Resources Information Center

Hebert, Margaret; And Others

1991-01-01

Contains seven brief articles which offer assignments designed to help students perform job searches, write job application letters, answer difficult questions, write letters of resignation, alleviate fears of public speaking, use the interview effectively in the business communication, and develop listening skills. (PRA)

Fabrication of multiwall carbon nanotube sheet based hydrogen sensor on a stacking multi-layer structure.

PubMed

Yan, Keyi; Toku, Yuhki; Morita, Yasuyuki; Ju, Yang

2018-06-22

In this research, we propose a new simple method to fabricate hydrogen gas sensor by stacking the multiwall carbon nanotube (MWCNT) sheets. MWCNT sheet offers a larger surface area and more CNT contacts, which are key factors for gas sensing, because of its super-high alignment and end-to-end structure comparing to the traditional CNT film. Besides, MWCNT sheet can be directly drawn from the spinnable CNT array in large scales. Therefore, this method is a potential answer for the mass production and commercialization of CNT based sensor with high response. By stacking different layers of sheet, microstructure and CNT interactions in the layers were changed and their influences towards gas sensing were investigated. It was observed that the sample with 3 layers of sheet and functionalized with 3 nm-thick Pd showed the best gas sensing performance with a response of 12.31% at 4% H2 and response time below 200 s. © 2018 IOP Publishing Ltd.

A Multidisciplinary First-Year Seminar about Tuberculosis.

ERIC Educational Resources Information Center

Fluck, Richard A.

2001-01-01

Describes a writing intensive seminar for college freshman. Includes goals, reading assignments, writing assignments, and group projects. Provides web-based resources on tuberculosis along with an evaluation sheet for web site reviews. Concludes that students exhibited great interest in the topic and course feedback was positive. (DLH)

Choosing a Pest Control Company

EPA Pesticide Factsheets

If you have a pest control problem that you do not want to handle on your own, you may decide to turn to a professional applicator. Before you choose a company, get answers to the questions in this fact sheet.

The Effect on One's Own Performance of Evaluating Peers.

ERIC Educational Resources Information Center

Cohen, Stuart J.

Fifty-three high school males took a minicourse on library usage. All were randomly assigned a topic and given response sheets requiring the use of dictionaries, encyclopedias, periodicals, and books. In a discussion session, all received instructional handouts. Students were assigned either to evaluating two peers' pretests (experimental) or…

Student Assignment Information, 1984-1985. Boston Public Schools.

ERIC Educational Resources Information Center

Boston Public Schools, MA. Dept. of Implementation.

This booklet provides parents and students with information about individual schools and programs within the Boston Public School system. The first section answers common questions about enrollment procedures, school assignments, bilingual education programs, kindergarten, transportation eligibility, family changes of address, and parent…

Validations of the Character Mosaic Report

DTIC Science & Technology

2011-10-01

Distort or embellish the truth  Cheating (Cronbach’s alpha value of 0.82) o Copy someone else’s test answer(s) o Plagiarize all or parts of...the “General Answer Sheet Type A” (purple, USAFA Form 150) in recording  your answers.  2. GRID:  Print your  academic  year squadron in the third and...How frequently during your final four years of high school did you “ plagiarize  all or parts of someone  else’s work”?  1. Never    2. Once    3. 2‐5

Camp Minden Fact Sheet June 2015

EPA Pesticide Factsheets

Details of the CBS, an alternative remedy selected by LMD, was the topic for a Community Meeting held May 28, 2015. Representatives from the EPA, LDEQ, and LMD were available to answer questions from from the community on removal actions.

Using Written-Answer Questions To Complement Numerical Problems. Case Study: A Separation Processes Course.

ERIC Educational Resources Information Center

Iveson, Simon M.

2002-01-01

Describes the process and outcome of including in assignments and examinations some questions requiring written answers along with traditional questions requiring only numerical calculations. Lists questions used in a chemical engineering course on separation processes along with sample responses from students. Student feedback indicates a…

Apparel Marketing. [Student Manual] and Answer Book/Teacher's Guide.

ERIC Educational Resources Information Center

Gaskill, Melissa Lynn

This document on apparel marketing contains both a student's manual and an answer book/teacher's guide. The student's manual contains the following 16 assignments: (1) introduction to fashion and fashion merchandising; (2) current fashion; (3) careers in fashion; (4) buying; (5) retailing; (6) merchandise basics; (7) merchandise--promotion and…

Supermarket Special Departments. [Student Manual] and Answer Book/Teacher's Guide.

ERIC Educational Resources Information Center

Gaskill, Melissa Lynn; Summerall, Mary

This document on food marketing for supermarket special departments contains both a student's manual and an answer book/teacher's guide. The student's manual contains the following 11 assignments: (1) supermarkets of today; (2) merchandising; (3) pharmacy and cosmetics department; (4) housewares and home hardware; (5) video/camera/electronics…

Using Computers in Undergraduate Economics Courses.

ERIC Educational Resources Information Center

Barr, Saul Z.; Harmon, Oscar

Seven computer assignments for undergraduate economics students that concentrate on building a foundation for programming higher level mathematical calculations are described. The purpose of each assignment, the computer program for it, and the correct answers are provided. "Introduction to Text Editing" acquaints the student with some…

ELECTRICAL AND ELECTRONIC INDUSTRIAL CONTROL. BASIC ELECTRICITY, UNIT 3, ASSIGNMENTS.

ERIC Educational Resources Information Center

SUTTON, MACK C.

THIS GUIDE IS FOR INDIVIDUAL STUDENT USE IN STUDYING BASIC ELECTRICAL FUNDAMENTALS IN ELECTRICAL-ELECTRONIC PROGRAMS. IT WAS DEVELOPED BY AN INSTRUCTIONAL MATERIALS SPECIALIST AND ADVISERS. THE COURSE OBJECTIVE IS TO DEVELOP AN UNDERSTANDING OF DIRECT CURRENT FUNDAMENTALS. EACH OF THE 10 ASSIGNMENT SHEETS PROVIDES THE LESSON SUBJECT, PURPOSE,…

ELECTRICAL AND ELECTRONIC INDUSTRIAL CONTROL. D-C MAGNETIC MOTOR CONTROL, UNIT 7, ASSIGNMENTS.

ERIC Educational Resources Information Center

SUTTON, MACK C.

THIS GUIDE IS FOR INDIVIDUAL STUDENT USE IN STUDYING DIRECT CURRENT MAGNETIC MOTOR CONTROL IN ELECTRICAL-ELECTRONIC PROGRAMS. IT WAS DEVELOPED BY AN INSTRUCTIONAL MATERIALS SPECIALIST AND ADVISERS. EACH OF THE 15 ASSIGNMENT SHEETS PROVIDES THE LESSON SUBJECT, PURPOSE, INTRODUCTORY INFORMATION, STUDY REFERENCES, AND PROBLEMS. SOME OF THE LESSONS…

ELECTRICAL AND ELECTRONIC INDUSTRIAL CONTROL. A-C CONVENTIONAL MAGNETIC MOTOR CONTROL, PART I, UNIT 5, ASSIGNMENTS.

ERIC Educational Resources Information Center

SUTTON, MACK C.

THIS GUIDE IS FOR INDIVIDUAL STUDENT USE IN STUDYING ALTERNATING CURRENT CONVENTIONAL MAGNETIC MOTOR CONTROL IN ELECTRICAL-ELECTRONIC PROGRAMS. IT WAS DEVELOPED BY AN INSTRUCTIONAL MATERIALS SPECIALIST AND ADVISERS. EACH OF THE 10 ASSIGNMENT SHEETS PROVIDES THE LESSON SUBJECT, PURPOSE, INTRODUCTORY INFORMATION, STUDY REFERENCES, SUPPLEMENTARY…

ELECTRICAL AND ELECTRONIC INDUSTRIAL CONTROL. BASIC ELECTRICITY, UNIT 2, ASSIGNMENTS.

ERIC Educational Resources Information Center

SUTTON, MACK C.

THIS GUIDE IS FOR INDIVIDUAL STUDENT USE IN STUDYING BASIC ELECTRICAL FUNDAMENTALS IN ELECTRICAL-ELECTRONIC PROGRAMS. IT WAS DEVELOPED BY AN INSTRUCTIONAL MATERIALS SPECIALIST AND ADVISERS. THE COURSE OBJECTIVE IS TO DEVELOP AN UNDERSTANDING OF DIRECT CURRENT FUNDAMENTALS. EACH OF THE 15 ASSIGNMENT SHEETS PROVIDES THE LESSON SUBJECT, PURPOSE,…

Accreditation Fact Sheet.

ERIC Educational Resources Information Center

National Association of Private, Nontraditional Schools and Colleges, Grand Junction, CO.

Questions and answers concerning accreditation of postsecondary institutions are presented, along with a list of personal/organizational sources and bibliographical sources of information. Information is provided on the following: accreditation and its origin, the Council on Postsecondary Accreditation, the U.S. Department of Education, the…

BARBERING, A STUDY GUIDE AND PROGRESSION RECORD FOR BARBERING STUDENTS IN A COOPERATIVE TRAINING PROGRAM.

ERIC Educational Resources Information Center

Alabama Univ., University.

QUESTION-TYPE JOB OR ASSIGNMENT SHEETS IN THIS GUIDE DIRECT THE STUDENT'S RELATED STUDY IN COOPERATIVE TRAINING PROGRAMS. THE MATERIAL WAS DEVELOPED BY TRADE AND INDUSTRIAL COORDINATORS, SUBJECT MATTER SPECIALISTS, AND TEACHER EDUCATORS. IT WAS TESTED BY USE IN HIGH SCHOOL PROGRAMS. THE 61 JOB SHEETS ARE KEYED TO THREE RELATED REFERENCE BOOKS, BUT…

Are Lung Imaging Reporting and Data System Categories Clear to Radiologists? A Survey of the Korean Society of Thoracic Radiology Members on Ten Difficult-to-Classify Scenarios.

PubMed

Han, Dae Hee; Goo, Jin Mo; Chong, Semin; Ahn, Myeong Im

2017-01-01

To evaluate possible variability in chest radiologists' interpretations of the Lung Imaging Reporting and Data System (Lung-RADS) on difficult-to-classify scenarios. Ten scenarios of difficult-to-classify imaginary lung nodules were prepared as an online survey that targeted Korean Society of Thoracic Radiology members. In each question, a description was provided of the size, consistency, and interval change (new or growing) of a lung nodule observed using annual repeat computed tomography, and the respondent was instructed to choose one answer from five choices: category 2, 3, 4A, or 4B, or "un-categorizable." Consensus answers were established by members of the Korean Imaging Study Group for Lung Cancer. Of the 420 answers from 42 respondents (excluding multiple submissions), 310 (73.8%) agreed with the consensus answers; eleven (26.2%) respondents agreed with the consensus answers to six or fewer questions. Assigning the imaginary nodules to categories higher than the consensus answer was more frequent (16.0%) than assigning them to lower categories (5.5%), and the agreement rate was below 50% for two scenarios. When given difficult-to-classify scenarios, chest radiologists showed large variability in their interpretations of the Lung-RADS categories, with high frequencies of disagreement in some specific scenarios.

Wholesale Selling, a Distributive Education Manual and Answer Book.

ERIC Educational Resources Information Center

Batis, Harry P.

This document containing assignments on 16 varied topics, with objectives, content information, and a separate answer book was designed to be used by secondary or post-secondary distributive education students and by wholesale distributors for use as training guides for employees. Topics discussed include: (1) thinking about selling today, (2)…

Providing Adequate Interactions in Online Discussion Forums Using Few Teaching Assistants

ERIC Educational Resources Information Center

Chang, Chih-Kai; Chen, Gwo-Dong; Hsu, Ching-Kun

2011-01-01

In order to encourage students to participate in online learning forums, prompt responses to their questions are essential. To answer students' online questions, teaching assistants are assigned to manage discussions and answer questions in online learning forums. To minimize the response time, many teaching assistants may be needed to interact…

Drugstore Selling and Merchandising, a Distributive Education Manual and Answer Book.

ERIC Educational Resources Information Center

Adams, J. David

This manual on drugstore selling and merchandising, together with a separate answer key, is intended for trainees in distributive education. The 18 self-study assignments, developed by an instructional coordinator with the aid of college professors and leaders in business, cover a wide range of topics, from effective sales techniques to specific…

Randomized controlled trials in evidence-based mental health care: getting the right answer to the right question.

PubMed

Essock, Susan M; Drake, Robert E; Frank, Richard G; McGuire, Thomas G

2003-01-01

The purpose of clinical research is to answer this question: Would a new treatment, when added to the existing range of treatment options available in practice, help patients? Randomized controlled trials (RCTs)--in particular, double-blind RCTs--have important methodological advantages over observational studies for addressing this question. These advantages, however, come at a price. RCTs compare treatments using a particular allocation rule for assigning patients to treatments (random assignment) that does not mimic real-world practice. "Favorable" results from an RCT indicating that a new treatment is superior to existing treatments are neither necessary nor sufficient for establishing a "yes" answer to the question posed above. Modeled on an experimental design, RCTs are expensive in time and money and must compare simple differences in treatments. Findings have a high internal validity but may not address the needs of the field, particularly where treatment is complex and rapidly evolving. Design of clinical research needs to take account of the way treatments are allocated in actual practice and include flexible designs to answer important questions most effectively.

EPA's Study of Hydraulic Fracturing and Its Potential Impact on Drinking Water Resources

EPA Pesticide Factsheets

EPA released the final report for the study of fracking's impact on drinking water in December 2016. Here you can find a summary of the report, the full report, some frequent questions and answers and fact sheets.

PV FAQs: Will We Have Enough Materials for Energy-Significant PV Production?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2004-01-01

This PV FAQ fact sheet discusses whether we will have enough of the feedstock materials used for energy-significant PV production. The answer is that, for a set amount of PV production, we will indeed have enough materials.

A Bayesian truth serum for subjective data.

PubMed

Prelec, Drazen

2004-10-15

Subjective judgments, an essential information source for science and policy, are problematic because there are no public criteria for assessing judgmental truthfulness. I present a scoring method for eliciting truthful subjective data in situations where objective truth is unknowable. The method assigns high scores not to the most common answers but to the answers that are more common than collectively predicted, with predictions drawn from the same population. This simple adjustment in the scoring criterion removes all bias in favor of consensus: Truthful answers maximize expected score even for respondents who believe that their answer represents a minority view.

Promoting Discussion in Peer Instruction: Discussion Partner Assignment and Accountability Scoring Mechanisms

ERIC Educational Resources Information Center

Chou, Chih-Yueh; Lin, Pin-Hsun

2015-01-01

Peer instruction (PI) involves students answering questions and peer discussion learning activities. PI can enhance student performance and engagement in classroom instruction. However, some students do not engage in the discussions. This study proposes two mechanisms, discussion partner assignment and accountability scoring mechanisms, to form…

Undertaking an International Assignment.

ERIC Educational Resources Information Center

Kitinoja, Lisa; And Others

Agricultural and extension educators interested in international agricultural development must answer several questions to become oriented within the field before undertaking an international assignment. The questions are as follows: (1) why do you want to work internationally? (2) what do you have to offer as a professional? and (3) what is your…

Determination of Flaw Growth Characteristics of Ti-6Al-4V Sheet in the Solution-Treated and Aged Condition

NASA Technical Reports Server (NTRS)

Hoeppner, David W.; Pettit, Donald E.; Feddersen, Charles E.; Hyler, Walter S.

1968-01-01

The specific experimental investigation undertaken was designed to answer these questions on Ti-6Al-4V in the solution treated and aged condition. The defect growth and fracture characteristics were studied in parent (unwelded) and welded sheet material. The results of the study indicate that cryogenic proof testing will screen smaller size defects than proof testing at ambient conditions. However some unusual crack growth behavior during the proof test simulation suggests that some further study be made of stress and time duration effects.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wemmer, D.E.; Kumar, N.V.; Metrione, R.M.

Toxin II from Radianthus paumotensis (Rp/sub II/) has been investigated by high-resolution NMR and chemical sequencing methods. Resonance assignments have been obtained for this protein by the sequential approach. NMR assignments could not be made consistent with the previously reported primary sequence for this protein, and chemical methods have been used to determine a sequence with which the NMR data are consistent. Analysis of the 2D NOE spectra shows that the protein secondary structure is comprised of two sequences of ..beta..-sheet, probably joined into a distorted continuous sheet, connected by turns and extended loops, without any regular ..cap alpha..-helical segments.more » The residues previously implicated in activity in this class of proteins, D8 and R13, occur in a loop region.« less

Aircraft Environmental Systems Mechanic. Part 2.

ERIC Educational Resources Information Center

Chanute AFB Technical Training Center, IL.

This packet contains learning modules designed for a self-paced course in aircraft environmental systems mechanics that was developed for the Air Force. Learning modules consist of some or all of the following materials: objectives, instructions, equipment, procedures, information sheets, handouts, workbooks, self-tests with answers, review…

Facts about Hib Disease. ARC Facts.

ERIC Educational Resources Information Center

Association for Retarded Citizens, Arlington, TX.

The fact sheet provides basic information about Hib Disease in young children, which may involve a bacterial meningitis causing mental retardation, hearing loss, partial blindness, speech disorders, partial paralysis, behavioral problems, or seizures. Stressed is prevention of Hib Disease through immunization. The question and answer format…

Living with Volcanoes: Year Eleven Teaching Resource Unit.

ERIC Educational Resources Information Center

Le Heron, Kiri; Andrews, Jill; Hooks, Stacey; Larnder, Michele; Le Heron, Richard

2000-01-01

Presents a unit on volcanoes and experiences with volcanoes that helps students develop geography skills. Focuses on four volcanoes: (1) Rangitoto Island; (2) Lake Pupuke; (3) Mount Smart; and (4) One Tree Hill. Includes an answer sheet and resources to use with the unit. (CMK)

Homework and Academic Achievement: A Meta-Analytic Review of Research

ERIC Educational Resources Information Center

Bas, Gökhan; Sentürk, Cihad; Cigerci, Fatih Mehmet

2017-01-01

The main purpose of this study was to determine the effect of homework assignments on students' academic achievement. This meta-analysis sought an answer to the research question: "What kind of effect does homework assignment have on students' academic achievement levels?" In this research, meta-analysis was adopted to determine the…

Basic Visual Merchandising. Second Edition. [Student's Manual and] Answer Book/Teacher's Guide.

ERIC Educational Resources Information Center

Luter, Robert R.

This student's manual that features content needed to do tasks related to visual merchandising is intended for students in co-op training stations and entry-level, master employee, and supervisory-level employees. It contains 13 assignments. Each assignment has questions covering specific information and also features activities in which students…

"Yes, a T-Shirt!": Assessing Visual Composition in the "Writing" Class

ERIC Educational Resources Information Center

Odell, Lee; Katz, Susan M.

2009-01-01

Computer technology is expanding our profession's conception of composing, allowing visual information to play a substantial role in an increasing variety of composition assignments. This expansion, however, creates a major problem: How does one assess student work on these assignments? Current work in assessment provides only partial answers to…

AVAILABLE INSTRUCTIONAL MATERIALS.

ERIC Educational Resources Information Center

Indiana State Univ., Terre Haute.

THE INSTRUCTIONAL MATERIALS INCLUDE PROGRAM BROCHURES, CHARTS, COURSE OUTLINES, OVERHEAD TRANSPARENCIES, ASSIGNMENT SHEETS, STUDENT MANUALS, TEACHER MANUALS, TECHNICAL INFORMATION, AND RELATED INFORMATION IN VOCATIONAL EDUCATION. A BRIEF NOTE DESCRIBES EACH. (EM)

Housing and Home Furnishings Modules.

ERIC Educational Resources Information Center

Clemson Univ., SC. Vocational Education Media Center.

These sixty-seven modules provide student materials for a home economics course in housing and home furnishings. (A companion instructor's guide is available separately--see note.) Each module contains an objective, student information, learning activities (and activity sheets as needed), student self-checks, student self-check answers, check-out…

Pneumatics.

ERIC Educational Resources Information Center

Engelbrecht, Nancy; And Others

This unit on pneumatics, for use in postsecondary programs, is organized in eight sections. Each section consists of information sheets with line drawings and multiple-choice questions for each topic in the sections. Answers are provided at the back of the book. The following topics are covered: (1) introduction--pressure, principles of gases,…

Aircraft Environmental Systems Mechanic. Part 1.

ERIC Educational Resources Information Center

Chanute AFB Technical Training Center, IL.

This packet contains learning modules for a self-paced course in aircraft environmental systems mechanics that was developed for the Air Force. Each learning module consists of some or all of the following: objectives, instructions, equipment, procedures, information sheets, handouts, self-tests with answers, review section, tests, and response…

Partnership to Advance Alternative Fuel Vehicles; Ciudades Limpias: Alianza Para Promover El Uso De Vehiculos De Combustibles Alternativos (in Spanish)

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaRocque, T.

2001-10-01

This fact sheet provides a question and answer overview of the Clean Cities program including what it is, how it works, the program's accomplishments, and a map of Clean Cities throughout the United States.

Computer vs. Workbook Instruction in Second Language Acquisition.

ERIC Educational Resources Information Center

Nagata, Noriko

1996-01-01

Compares the effectiveness of Nihongo-CALI (Japanese Computer Assisted Language Instruction) with non-CALI workbook instruction. Findings reveal that given the same grammar notes and exercises, ongoing intelligent computer feedback is more effective than simple workbook answer sheets for developing learners' grammatical skill in producing Japanese…

Dinosaurs.

ERIC Educational Resources Information Center

Miller, Vicki; Happel, Sue

Facts, activities, and student worksheets about dinosaurs are presented. General information about dinosaurs (when they lived and what they were like) and fossils (how they are created and what information they can provide) is followed by a worksheet and answer sheet. A timeline of the dinosaur age and a classification chart which divides…

Learning Science Process Through Data Exploration and Writing

NASA Astrophysics Data System (ADS)

Prothero, W. A.

2007-12-01

One of the most effective ways of teaching science process is to have students take part in the same activities that practicing scientists engage in. These activities include studying the current research in the field, discussing ideas with colleagues, formulating a research problem, making a proposal defining the problem and plan of attack, presenting and writing about the results of the study, and critically reviewing the work of others. An inquiry curriculum can use these activities to guide the scaffolding of assignments and learning experiences that help students learn science process. At UCSB, students in a large general education oceanography class use real Earth data to study plate tectonics, the Indian Monsoon, climate change, and the health of the world fisheries. The end product for each subject has been a science paper based on Earth data. Over a period of approximately 15 years, the scaffolding of activities to prepare each student for the written assignments has been modified and improved, in response to student feedback and their success with the assignments. I have found that the following resources and sequence of activities help the oceanography students write good science papers. 1. Lecture: motivation and the opportunity for feedback and questions. 2. Textbook: background information. It is also possible to get the information from the internet, but unless the scope of reading is strictly defined, students don't know when to stop reading and become unhappy. 3. Online assignments: automatically graded assignments that force the student to keep up with reading. 4. Questions of the day: in-class handouts, with diagrams that the students either complete, or answer questions about. They are handed in and tallied, but not graded. They also inform the instructor of misconceptions. 5. Thought questions: student answers are posted on a threaded discussion list, and are due prior to lecture. The answers provide instructor feedback and guide the lecture. Students see their peers' answers only after entering their own. They can then improve their own answer ("Just In Time Teaching"). 6. Laboratory section activities: these introduce students to the course software, especially the data browsers, and the meaning of the data for the next writing assignment. For each meeting, a group inquiry activity results in a short class presentation by each group. This informs the teaching assistant (who teaches the lab section) of student understanding of the material, helps students become comfortable with the software, and supports students helping each other. 7. Written assignments. The assignments each require an approximately 1100-1600 word paper that includes abstract, introduction, data, interpretation, summary, and references. Images are captured from the data browser and included in the paper. The writing technology has evolved from papers handed in and graded by hand, to fully online hand-in and grading, to calibrated peer review, which was incorporated in the 2005 course. Calibrated peer review has the advantage that students see and evaluate their peers' papers. About 20% of the papers are graded by the instructor, resulting in a much lower instructor grading workload. Also, I suspect that a greater number of very short writing assignments in response to thought questions or min- inquiries might be an effective modification. The new "Learning With Data Workshop" will support many of the inquiry activities described here.

Unit Charge, First Trial Materials, Inspection Set.

ERIC Educational Resources Information Center

Australian Science Education Project, Toorak, Victoria.

The first trial edition of the Australian Science Education Project unit introducing the concepts of electrical charge consists of a student workbook, question booklet and a response sheet, and a booklet containing answers to the questions in the workbook and question booklet. The teacher's guide outlines the unit, lists suggested teaching…

Nutrition. Learning Activity Package.

ERIC Educational Resources Information Center

Lee, Carolyn

This learning activity package on nutrition is one of a series of 12 titles developed for use in health occupations education programs. Materials in the package include objectives, a list of materials needed, a list of definitions, information sheets, reviews (self evaluations) of portions of the content, and answers to reviews. These topics are…

Shock & Anaphylactic Shock. Learning Activity Package.

ERIC Educational Resources Information Center

Hime, Kirsten

This learning activity package on shock and anaphylactic shock is one of a series of 12 titles developed for use in health occupations education programs. Materials in the package include objectives, a list of materials needed, information sheets, reviews (self evaluations) of portions of the content, and answers to reviews. These topics are…

Perhaps the Professor Should Cut Class.

ERIC Educational Resources Information Center

Fisher, Lester A.; Murray, Donald M.

A basic college composition course without class meetings in which the instructors responded individually to each student's writing is described. The content of the course was each student's writing and the teaching method was the student writing and the teacher reacting in conference. Each student received a question-and-answer sheet, a brief…

Energy from the Atom.

ERIC Educational Resources Information Center

Smith, Patricia L.

This curriculum guide was written to supplement fifth and sixth grade science units on matter and energy. It was designed to provide more in-depth material on the atom. The first part, "Teacher Guide," contains background information, biographical sketches of persons in the history of nuclear energy, vocabulary, answer sheets, management sheets…

Radon Q & A. What You Need to Know.

ERIC Educational Resources Information Center

Bayham, Chris

1994-01-01

Because radon is the second leading cause of lung cancer in this country, the article presents a question and answer sheet on where radon comes from, which buildings are most likely to have radon, how to tell whether there is a problem, and expenses involved in testing and fixing problems. (SM)

Certified Nurse Assistant Certification Examination Test Booklet.

ERIC Educational Resources Information Center

Bonnot, Lois; And Others

This document contains four certification examinations (Forms A-D) for a certified nurse assistant in Missouri. Each of the four test booklets contains general instructions for completing the information section of the answer sheet, general instructions for taking the certification examination, and 100 questions. All test problems are in a…

Applied Physics Modules: Notes, Instructions, Data Sheets, Tests, and Test Answer Keys.

ERIC Educational Resources Information Center

Southeast Community Coll., Lincoln, NE.

These user instructions and related materials are designed to accompany a series of twenty-three applied physics modules which have been developed for postsecondary students in electrical, electronics, machine tool, metals, manufacturing, automotive, diesel, architecture, and civil drafting occupational programs. The instructions include an…

Direct Loan Overview Workshop. Participant's Guide.

ERIC Educational Resources Information Center

Department of Education, Washington, DC.

This training guide for a one-day workshop provides an introduction to the William D. Ford Federal Direct Loan Program for administrative personnel at higher educations institutions. The seven sections of the guide, each corresponding to a single workshop session, include activity sheets, questions for participants to answer, and space for notes.…

The Marfan Syndrome [and] Fact Sheet.

ERIC Educational Resources Information Center

Pyeritz, Reed E.; Conant, Julia

This introduction to the Marfan syndrome, a heritable disorder of connective tissue primarily affecting the bones and ligaments, eyes, cardiovascular system, and lungs, is intended for a general audience. The question-and-answer format was chosen by individuals with the syndrome to reflect their major questions and concerns. It incorporates the…

Machine Shop. Student Learning Guide.

ERIC Educational Resources Information Center

Palm Beach County Board of Public Instruction, West Palm Beach, FL.

This student learning guide contains eight modules for completing a course in machine shop. It is designed especially for use in Palm Beach County, Florida. Each module covers one task, and consists of a purpose, performance objective, enabling objectives, learning activities and resources, information sheets, student self-check with answer key,…

Prader-Willi Syndrome. ARC Q&A #101-52.

ERIC Educational Resources Information Center

Arc, Arlington, TX.

This fact sheet uses a question-and-answer format to summarize what is known about Prader-Willi Syndrome (PWS), a complex genetic disorder resulting in short stature, mental retardation or learning disabilities, incomplete sexual development, characteristic behavior problems, low muscle tone, and an involuntary urge to eat constantly, which…

Oral Hygiene. Learning Activity Package.

ERIC Educational Resources Information Center

Hime, Kirsten

This learning activity package on oral hygiene is one of a series of 12 titles developed for use in health occupations education programs. Materials in the package include objectives, a list of materials needed, a list of definitions, information sheets, reviews (self evaluations) of portions of the content, and answers to reviews. These topics…

Grooming. Learning Activity Package.

ERIC Educational Resources Information Center

Stark, Pamela

This learning activity package on grooming for health workers is one of a series of 12 titles developed for use in health occupations education programs. Materials in the package include objectives, a list of materials needed, information sheets, reviews (self evaluations) of portions of the content, and answers to reviews. These topics are…

The Direct Loan Reconciliation Game.

ERIC Educational Resources Information Center

Department of Education, Washington, DC.

This training guide for a one-day workshop provides an introduction to the William D. Ford Federal Direct Loan Program for administrative personnel at higher education institutions. The six sections of the guide, each corresponding to a workshop session, include activity sheets, questions for participants to answer, and space for notes. Following…

Darmok & Jalad at Tannagra: A Lesson in Cultural Communication and Writing.

ERIC Educational Resources Information Center

Staten, Karen A.

1996-01-01

Describes a writing assignment based on a "Star Trek: The Next Generation" episode in which an alien sacrifices his life so two cultures can come together. Provides questions for students to answer during the viewing of the episode. Suggests a writing assignment (and several variations) in which students create their own alien. (TB)

Physical Limits on Hmax, the Maximum Height of Glaciers and Ice Sheets

NASA Astrophysics Data System (ADS)

Lipovsky, B. P.

2017-12-01

The longest glaciers and ice sheets on Earth never achieve a topographic relief, or height, greater than about Hmax = 4 km. What laws govern this apparent maximum height to which a glacier or ice sheet may rise? Two types of answer appear possible: one relating to geological process and the other to ice dynamics. In the first type of answer, one might suppose that if Earth had 100 km tall mountains then there would be many 20 km tall glaciers. The counterpoint to this argument is that recent evidence suggests that glaciers themselves limit the maximum height of mountain ranges. We turn, then, to ice dynamical explanations for Hmax. The classical ice dynamical theory of Nye (1951), however, does not predict any break in scaling to give rise to a maximum height, Hmax. I present a simple model for the height of glaciers and ice sheets. The expression is derived from a simplified representation of a thermomechanically coupled ice sheet that experiences a basal shear stress governed by Coulomb friction (i.e., a stress proportional to the overburden pressure minus the water pressure). I compare this model to satellite-derived digital elevation map measurements of glacier surface height profiles for the 200,000 glaciers in the Randolph Glacier Inventory (Pfeffer et al., 2014) as well as flowlines from the Greenland and Antarctic Ice Sheets. The simplified model provides a surprisingly good fit to these global observations. Small glaciers less than 1 km in length are characterized by having negligible influence of basal melt water, cold ( -15C) beds, and high surface slopes ( 30 deg). Glaciers longer than a critical distance 30km are characterized by having an ice-bed interface that is weakened by the presence of meltwater and is therefore not capable of supporting steep surface slopes. The simplified model makes predictions of ice volume change as a function of surface temperature, accumulation rate, and geothermal heat flux. For this reason, it provides insights into both past and future global ice volume changes.

Challenges for understanding Antarctic surface hydrology and ice-shelf stability

NASA Astrophysics Data System (ADS)

Kingslake, J.; Bell, R. E.; Banwell, A. F.; Boghosian, A.; Spergel, J.; Trusel, L. D.

2017-12-01

It is widely hypothesized that surface meltwater can contribute to ice mass loss in Antarctica through its impact on ice-shelf stability. Meltwater potentially expedites ice-shelf calving by flowing into and enlarging existing crevasses, and could even trigger ice-shelf disintegration via stresses generated by melt ponds. When ice shelves collapse, the adjacent grounded ice accelerates and thins, which contributes to sea-level rise. How these mechanisms mediate the interactions between the atmosphere, the ocean and the ice sheet is the subject of long-standing research efforts. The drainage of water across the surface of the Antarctic Ice Sheet and its ice shelves is beginning to be recognized as another important aspect of the system. Recent studies have revealed that surface meltwater drainage is more widespread than previously thought and that surface hydrological systems in Antarctica may expand and proliferate this century. Contrasting hypotheses regarding the impact of the proliferation of drainage systems on ice-shelf stability have emerged. Surface drainage could deliver meltwater to vulnerable area or export meltwater from ice shelves entirely. Which behavior dominates may have a large impact on the future response of the Antarctic Ice Sheet to atmospheric warming. We will discuss these recent discoveries and hypotheses, as well as new detailed studies of specific areas where hydrological systems are well developed, such as Amery and Nimrod Ice Shelves. We will highlight analogies that can be drawn with Greenlandic (near-)surface hydrology and, crucially, where hydrological systems on the two ice sheets are very different, leading to potentially important gaps in our understanding. Finally, we will look ahead to the key questions that we argue will need to be if we are to determine the role Antarctic surface hydrology could play in the future of the ice sheet. These include: Where does meltwater pond today and how will this change this century? What coupled glaciological-hydrological dynamics control how drainage systems will change as melt rates increase this century? How do we incorporate surface hydrology into ice-sheet models? While we may be currently unable to answer these and related questions, we aim to start the discussion on how the community can move towards answering them in the future.

How did you guess? Or, what do multiple-choice questions measure?

PubMed

Cox, K R

1976-06-05

Multiple-choice questions classified as requiring problem-solving skills have been interpreted as measuring problem-solving skills within students, with the implicit hypothesis that questions needing an increasingly complex intellectual process should present increasing difficulty to the student. This hypothesis was tested in a 150-question paper taken by 721 students in seven Australian medical schools. No correlation was observed between difficulty and assigned process. Consequently, the question-answering process was explored with a group of final-year students. Anecdotal recall by students gave heavy weight to knowledge rather than problem solving in answering these questions. Assignment of the 150 questions to the classification by three teachers and six students showed their congruence to be a little above random probability.

Interagency Exchanges at Military Universities: Do Concerns About Finances, Career Progression and Assignments Affect Foreign Service Officers and Specialists’ Willingness to Participate?

DTIC Science & Technology

2015-06-12

benefits as well as its drawbacks , the results to this partition of the survey are extremely important to answering the primary research question. Are...Responses include: Too political. In my opinion, the assignment process is far from transparent. The assignment’s process sucks and the pendulum has... pendulum has swung back to “who you know”. Experience and prior work history is not taking into consideration when making assignments. And the process

Using Just in Time Teaching in a Global Climate Change Course to Address Misconceptions

NASA Astrophysics Data System (ADS)

Schuenemann, K. C.

2013-12-01

Just in Time Teaching (JiTT) is employed in an introductory Global Climate Change college course with the intention of addressing common misconceptions and climate myths. Students enter the course with a variety of prior knowledge and opinions on global warming, and JiTT can be used as a constructivist pedagogical approach to make use of this prior knowledge. Students are asked to watch a short video or do a reading, sometimes screen capture videos created by the professor as review of material from the previous class, a video available on the web from NASA or NOAA, for example, or a reading from an online article or their textbook. After the video or reading, students answer a question carefully designed to pry at a common misconception, or simply are asked for the 'muddiest point' that remains on the concept. This assignment is done the night before class using a web program. The program aggregates the answers in an organized way so the professor can use the answers to design the day's lesson to address common misconceptions or concerns students displayed in their answers, as well as quickly assign participation credit to students who completed the assignment. On the other hand, if students display that they have already mastered the material, the professor can confidently move on to the next concept. The JiTT pedagogical method personalizes each lecture period to the students in that particular class for maximum efficiency while catching and fixing misconceptions in a timely manner. This technique requires students to spend time with the material outside of class, acts as review of important concepts, and increases engagement in class due to the personalization of the course. Evaluation results from use of this technique will be presented. Examples of successful JiTT videos, questions, student answers, and techniques for addressing misconceptions during lecture will also be presented with the intention that instructors can easily apply this technique to their next course.

Developing effective assignment feedback for an interprofessional learning module-An action research project.

PubMed

Strudwick, Ruth; Day, Jane

2015-09-01

The first year interprofessional learning module at University Campus Suffolk (UCS) is delivered to 300 students and the students' assignments are marked by 20 members of staff from different health and social care professions. We were keen to find a way to reduce any inconsistencies and work with both staff and students to ensure that the essay and subsequent feedback were useful for all involved. The aims of the project were to evaluate the current marking process and feedback sheets used for year one inter-professional learning (IPL) marking, and to develop an appropriate marking tool and feedback sheet that would enable markers to provide more consistent feedback to the students. Participatory action research was used with both students and staff members being involved. Focus group and questions were used to ascertain views about the assignment feedback. The feedback from this action learning project helped us to enhance the feedback for students. There was also an increase in engagement with the assessment and feedback process amongst both staff and students. Copyright © 2015 Elsevier Ltd. All rights reserved.

Polytomous versus Dichotomous Scoring on Multiple-Choice Examinations: Development of a Rubric for Rating Partial Credit

ERIC Educational Resources Information Center

Grunert, Megan L.; Raker, Jeffrey R.; Murphy, Kristen L.; Holme, Thomas A.

2013-01-01

The concept of assigning partial credit on multiple-choice test items is considered for items from ACS Exams. Because the items on these exams, particularly the quantitative items, use common student errors to define incorrect answers, it is possible to assign partial credits to some of these incorrect responses. To do so, however, it becomes…

Facts about Alcohol and Other Drug Use during Pregnancy. ARC Facts.

ERIC Educational Resources Information Center

Association for Retarded Citizens, Arlington, TX.

The fact sheet provides basic information about how alcohol and drug use during pregnancy can lead to Fetal Alcohol Syndrome (FAS) and Alcohol Related Birth Defects (ARBD), resulting in such problems as mental retardation, sleep disturbances, learning disabilities, muscle problems, heart defects, and small head size. The question and answer format…

Test-Tampering Found Rampant in Atlanta System

ERIC Educational Resources Information Center

Samuels, Christina A.

2011-01-01

The author reports on a state investigation into Atlanta's impressive gains on state tests which finds that test-tampering was rampant in the much-praised school system. The report unveiled by the Georgia governor's office states that Atlanta teachers and principals for years methodically altered answer sheets for students taking state tests,…

Liability Insurance Questions and Answers for Physical Education and Recreation Personnel. Topical Information Sheet No. 3.

ERIC Educational Resources Information Center

American Alliance for Health, Physical Education, and Recreation, Washington, DC.

Provided are guidelines for physical education and recreation personnel regarding liability insurance. It is noted that recent trends toward including handicapped persons in community recreation, sports, and regular physical education programs have raised concerns among involved personnel. Brief sections cover the following topics: definition of…

Interrelations of Down Syndrome and Alzheimer Disease. ARC Facts.

ERIC Educational Resources Information Center

Schweber, Miriam

This fact sheet summarizes the interrelations of Down syndrome and Alzheimer disease in a question and answer format. The following questions are addressed: What is Alzheimer disease? Why is a relationship suggested between Down syndrome and Alzheimer disease? Is there a genetic link between Alzheimer disease and Down syndrome? Why is a…

The Surgical Scrub. Learning Activity Package.

ERIC Educational Resources Information Center

Runge, Lillian

This learning activity package on the surgical scrub is one of a series of 12 titles developed for use in health occupations education programs. Materials in the package include objectives, a list of materials needed, a list of definitions, information sheets, reviews (self evaluations) of portions of the content, and answers to reviews. These…

Radiology Aide. Instructor Key [and] Student Manual.

ERIC Educational Resources Information Center

Hartwein, Jon; Dunham, John

This manual can be used independently by students in secondary health occupations programs or by persons receiving on-the-job training in a radiology department. The manual includes an instructor's key that provides answers to the activity sheets and unit evaluations. The manual consists of the following five units: (1) orientation to radiology;…

Improving the Test-Taking Skills of Learning Disabled Students.

ERIC Educational Resources Information Center

Scruggs, Thomas E.; Jenkins, Vesna

Research on test taking skills of LD (learning disabled) students is reviewed and implications for improving the skill are noted. Among findings considered are that separate answer sheets appear to inhibit the performance of LD students, LD students can benefit from training and demonstrate improved attitudes toward testing, and students should…

Reye's Syndrome. The Arc Q & A.

ERIC Educational Resources Information Center

Reynolds, Leigh Ann

This fact sheet uses a question-and-answer format to summarize what is known about Reye's Syndrome, a disease probably caused by ingestion of salicylate, which affects all organs of the body but especially the liver and brain, often resulting in neurological abnormalities and mental retardation. The following topics on the subject are covered:…

Participatory assessment of the environment from children's viewpoints: development of a method and its trial.

PubMed

Moriyama, M; Suwa, T; Kabuto, M; Fukushima, T

2001-02-01

To understand the actual viewpoints of children about daily life and the environment, the authors, adopting a participatory strategy, visited 21 classes of Japanese school children, improved in a stepwise process their ways of question-asking, and developed "WIFY"(what is important for you); a set of interactive questions composed of a basic question and three accompanying instructions. In applying WIFY, 59 fourth graders, 22 in Nagasaki, Japan and 37 in Beijing, China, reported their viewpoints in each of classroom settings. In both settings, when children were allowed to communicate with each other by the use of WIFY answering sheet, spontaneous exchanges arose and continued. WIFY itself is supposed to bring out and enhance mutual collaboration and spontaneous networking. In this instance, WIFY functioned as a communication tool. When answering sheets were collected and obtained responses were analyzed as cases, a rather materialistic view was suggested among Japanese children and a more disciplined view, which put much value on school and home, was suggested among Chinese children. Further studies are needed to confirm the changing environmental views of children from the collaborative research framework.

What Is Child Abuse and Neglect?

ERIC Educational Resources Information Center

US Department of Health and Human Services, 2006

2006-01-01

Each State provides its own definitions of child abuse and neglect based on minimum standards set by Federal law. This fact sheet provides the answers to the following questions: (1) How is child abuse and neglect defined in Federal law?; and (2) What are the major types of child abuse and neglect? Additional resources are listed. (Contains 2…

Do-It-Yourself Guide to: A Solid Waste Seminar. Construction Plans and Use Guidelines.

ERIC Educational Resources Information Center

Quarry Hill Nature Center, Rochester, Minn.

Ten learning stations dealing with solid waste comprise the seminar described in this booklet. At each station, students observe a display and then answer questions listed on their data sheets. Although the seminar was intended for junior high school students, it has been used successfully with upper elementary and adult participants. Among the…

Coal combustion products

USGS Publications Warehouse

Kalyoncu, R.S.; Olson, D.W.

2001-01-01

Coal-burning powerplants, which supply more than half of U.S. electricity, also generate coal combustion products, which can be both a resource and a disposal problem. The U.S. Geological Survey collaborates with the American Coal Ash Association in preparing its annual report on coal combustion products. This Fact Sheet answers questions about present and potential uses of coal combustion products.

Nurse Assistant in Acute, Home Health and Long-Term Care Settings. Instructor Manual [and] Student Manual.

ERIC Educational Resources Information Center

Winberg, Pat

This document consists of an instructor's manual and student manual for a nurse assistant curriculum. The instructor's manual provides answers to activity sheets and unit evaluations along with individual unit overviews. Suggested teaching strategies and audiovisual supplements are included for each lesson. The student manual contains eight units:…

PRE-COLLEGE EXPERIENCES AS PREPARATION FOR COLLEGE COURSES IN AGRONOMY.

ERIC Educational Resources Information Center

BEEKS, JOHN C.

TO DETERMINE THE KNOWLEDGE OF AGRONOMY POSSESSED BY ENTERING FRESHMEN IN THE COLLEGE OF AGRICULTURE AT THE UNIVERSITY OF MISSOURI, STUDENTS ENROLLED IN THE REQUIRED COURSE AGRICULTURE IN THE ECONOMY DURING THE YEARS 1962 AND 1963 RESPONDED TO A 100-ITEM MULTIPLE CHOICE INSTRUMENT. A TOTAL OF 310 USABLE ANSWER SHEETS FURNISHED DATA ON STUDENTS--(1)…

Psychological Evaluation of Children Who Are Deaf-Blind: An Overview with Recommendations for Practice. Revised

ERIC Educational Resources Information Center

Mar, Harvey

2010-01-01

This fact sheet provides answers to frequently asked questions about psychological evaluations for infants, children and adults who are deaf-blind, we hope to clarify the evaluation process and the active roles that may be taken by everyone who is involved--family members, professionals, educators, and the student. Finally, by discussing quality…

Objective, Structured Proforma to Score the Merit of Scientific Presentations.

PubMed

Agarwal, Nayan; Thawani, Rajat; Gupta, Setu; Sharma, Arun; Dhaliwal, Upreet

2015-12-01

Around 100,000 medical conferences are organized all over the world and hence, they form an integral part of a medical professional's life. Oral presentations, especially award sessions, are judged by a panel of faculty judges who score individual presentations on various aspects including content, delivery and submission. Our objective was to compare the scores given by student-judges and faculty-judges for scientific presentations using the standardized score sheet. An objective, structured score-sheet was designed using existing literature. Five presentations, all made using PowerPoint, were judged using the structured score-sheet by seven student-judges and two-faculty judges. The mean score of all the score-sheets (n = 45) was 38.5 + 5.4 (out of a maximum score of 50). There was no statistical difference between mean scores assigned by students or faculty (p = 0.2). Thus, an objective, structured score sheet like ours, when used to judge scientific presentations, gave uniform results even when judges hailed from different levels of the medical hierarchy.

3D 14N/1H Double Quantum/1H Single Quantum Correlation Solid-State NMR for Probing Parallel and Anti-Parallel Beta-Sheet Arrangement of Oligo-Peptides at Natural Abundance.

PubMed

Hong, You-Lee; Asakura, Tetsuo; Nishiyama, Yusuke

2018-05-08

β-sheet structure of oligo- and poly-peptides can be formed in anti-parallel (AP)- and parallel (P)-structure, which is the important feature to understand the structures. In principle, P- and AP-β-sheet structures can be identified by the presence (AP) and absence (P) of the interstrand 1HNH/1HNH correlations on a diagonal in 2D 1H double quantum (DQ)/1H single quantum (SQ) spectrum due to the different interstrand 1HNH/1HNH distances between these two arrangements. However, the 1HNH/1HNH peaks overlap to the 1HNH3+/1HNH3+ peaks, which always give cross peaks regardless of the β-sheet arrangement. The 1HNH3+/1HNH3+ peaks disturb the observation of the presence/absence of 1HNH/1HNH correlations and the assignment of 1HNH and 1HNH3+ is not always available. Here, 3D 14N/1H DQ/1H SQ correlation solid-state NMR experiments at fast magic angle spinning (70 kHz) are introduced to distinguish AP and P β-sheet structure. The 14N dimension allows the separate observation of 1HNH/1HNH peaks from 1HNH3+/1HNH3+ peaks with clear assignment of 1HNH and 1HNH3+. In addition, the high natural abundance of 1H and 14N enables 3D 14N/1H DQ/1H SQ experiments of oligo-alanines (Ala3-6) in four hours without any isotope labelling. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Self-Directed Learning with Feedback

ERIC Educational Resources Information Center

Choi, Youngeun; Anderson, William

2016-01-01

This article describes a weekly writing assignment named SelFeed (Self-Directed Learning with Feedback), in which students are asked to identify their own questions relevant to the lecture content and provide logical answers.

Introductory Statistics Students' Conceptual Understanding of Study Design and Conclusions

NASA Astrophysics Data System (ADS)

Fry, Elizabeth Brondos

Recommended learning goals for students in introductory statistics courses include the ability to recognize and explain the key role of randomness in designing studies and in drawing conclusions from those studies involving generalizations to a population or causal claims (GAISE College Report ASA Revision Committee, 2016). The purpose of this study was to explore introductory statistics students' understanding of the distinct roles that random sampling and random assignment play in study design and the conclusions that can be made from each. A study design unit lasting two and a half weeks was designed and implemented in four sections of an undergraduate introductory statistics course based on modeling and simulation. The research question that this study attempted to answer is: How does introductory statistics students' conceptual understanding of study design and conclusions (in particular, unbiased estimation and establishing causation) change after participating in a learning intervention designed to promote conceptual change in these areas? In order to answer this research question, a forced-choice assessment called the Inferences from Design Assessment (IDEA) was developed as a pretest and posttest, along with two open-ended assignments, a group quiz and a lab assignment. Quantitative analysis of IDEA results and qualitative analysis of the group quiz and lab assignment revealed that overall, students' mastery of study design concepts significantly increased after the unit, and the great majority of students successfully made the appropriate connections between random sampling and generalization, and between random assignment and causal claims. However, a small, but noticeable portion of students continued to demonstrate misunderstandings, such as confusion between random sampling and random assignment.

College Algebra I.

ERIC Educational Resources Information Center

Benjamin, Carl; And Others

Presented are student performance objectives, a student progress chart, and assignment sheets with objective and diagnostic measures for the stated performance objectives in College Algebra I. Topics covered include: sets; vocabulary; linear equations; inequalities; real numbers; operations; factoring; fractions; formulas; ratio, proportion, and…

Information brochure on the Department of Energy's proposed Waste Isolation Pilot Plant (WIPP) in southeastern New Mexico. Project overview

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This project overview comprises the following: project history; WIPP fact sheet; legal actions required; major WIPP milestones; low-level waste volumes; nuclear waste transportation; WIPP site selection; and questions and answers from the Department of Energy request for public input prior to public meetings in Roswell and Hobbs, New Mexico.

75 FR 24730 - Agency Information Collection Activities: Proposed Collection; Comment Request, 1660-0046; FEMA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-05

... cost State, local or Tribal Government; Business or FEMA/EMI Independent Study 1,682,231 4 6,728,924 0... Tribal Government; Business or FEMA/EMI Independent Study 186,914 4 747,656 0.75 560,742 28.45 15,953,110... Independent Study Course Enrollment and Test Answer Sheet AGENCY: Federal Emergency Management Agency, DHS...

Instructor's Manual for Electrical Apprentice Technical Training. Series No. D (Fourth Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Twenty-seven lesson plans for a fourth-year electrical apprentice technical training program are presented in this instructor's manual. Also included are student worksheets and information sheets for each lesson, and copies of unit tests. (Answers to the worksheets and tests are provided.) The lesson plans are generally organized into four steps:…

Instructor's Manual for Electrical Apprentice Technical Training. Series No. A (First Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Thirty-six lesson plans for the first of a four-year electrical apprentice technical training program are presented in this instructor's manual. Also included are student worksheets and information sheets for each lesson, and copies of unit tests. (Answers to the worksheets and tests are provided.) The lesson plans are generally organized into…

Instructor's Manual for Electrical Apprentice Technical Training. Series No. B (Second Year). Revised to Meet 1978 Electrical Code.

ERIC Educational Resources Information Center

North Carolina State Dept. of Community Colleges, Raleigh.

Twenty-eight lesson plans for the second year of a four-year electrical apprentice technical training program are presented in this instructor's manual. Also included are student worksheets and information sheets for each lesson, and copies of unit tests. (Answers to the worksheets and tests are provided.) The lesson plans are generally organized…

Crime in the Classroom: Analysis over 26 Years

ERIC Educational Resources Information Center

Harrp, David N.

2018-01-01

Copying adjacent answer sheets on the oft-used multiple-choice exams can be prevented if exam material is scrambled. The latter mode has been a requirement for all exams of this type at McGill University for 26 years. Cheating by copying has been reduced to nearly zero in this time. The experiment carried out used permissive seating and a single…

Applied Reading Test--Forms A and B, Interim Manual, and Answer Sheets.

ERIC Educational Resources Information Center

Australian Council for Educational Research, Hawthorn.

Designed for use in the selection of apprentices, trainees, technical and trade personnel, and any other persons who need to read and understand text of a technical nature, this Applied Reading Test specimen set contains six passages and 32 items, has a 30-minute time limit, and is presented in a reusable multiple choice test booklet. The specimen…

How I Feel About Some Other Kids.

ERIC Educational Resources Information Center

Purdue Univ., Lafayette, IN. Educational Research Center.

This rating scale was developed to yield a measure of peer acceptance and socialization for students in grades 1-6. Each child is asked to consider his classmates in terms of three sets of questions, each set having 20 items. The child responds to the question by circling yes or no or sometimes on the answer sheet. Items are organized around three…

Certainty rating in pre-and post-tests of study modules in an online clinical pharmacy course - A pilot study to evaluate teaching and learning.

PubMed

Luetsch, Karen; Burrows, Judith

2016-10-14

Graduate and post-graduate education for health professionals is increasingly delivered in an e-learning environment, where automated, continuous formative testing with integrated feedback can guide students' self-assessment and learning. Asking students to rate the certainty they assign to the correctness of their answers to test questions can potentially provide deeper insights into the success of teaching, with test results informing course designers whether learning outcomes have been achieved. It may also have implications for decision making in clinical practice. A study of pre-and post-tests for five study modules was designed to evaluate the teaching and learning within a pharmacotherapeutic course in an online postgraduate clinical pharmacy program. Certainty based marking of multiple choice questions (MCQ) was adapted for formative pre- and post-study module testing by asking students to rate their certainty of correctness of MCQ answers. Paired t-tests and a coding scheme were used to analyse changes in answers and certainty between pre-and post-tests. A survey evaluated students' experience with the novel formative testing design. Twenty-nine pharmacists enrolled in the postgraduate program participated in the study. Overall 1315 matched pairs of MCQ answers and certainty ratings between pre- and post-module tests were available for evaluation. Most students identified correct answers in post-tests and increased their certainty compared to pre-tests. Evaluation of certainty ratings in addition to correctness of answers identified MCQs and topic areas for revision to course designers. A survey of students showed that assigning certainty ratings to their answers assisted in structuring and focusing their learning throughout online study modules, facilitating identification of areas of uncertainty and gaps in their clinical knowledge. Adding certainty ratings to MCQ answers seems to engage students with formative testing and feedback and focus their learning in a web-based postgraduate pharmacy course. It also offers deeper insight into the successful delivery of online course content, identifying areas for improvement of teaching and content delivery as well as test question design.

The US-China Face-Off in the Asia-Pacific Region: What Answer Can the Offense-Defense Theory Provide

DTIC Science & Technology

2015-06-01

strike first ; and so on. A war between the two giants would clearly disrupt the global order. In order to find answers related to these security...Spartly Islands in the South. China has a long history of fishing in the area surrounding these islands. Arguably, China was the first country to assign...the region? Is there a possibility of war? Does China see advantage in striking first ? Who has the strategic advantage? How strong is the alliance

Microwave. Instructor's Edition. Louisiana Vocational-Technical Education.

ERIC Educational Resources Information Center

Blanton, William

This publication contains related study assignments and job sheets for a course in microwave technology. The course is organized into 12 units covering the following topics: introduction to microwave, microwave systems, microwave oscillators, microwave modulators, microwave transmission lines, transmission lines, detectors and mixers, microwave…

Status Report and Update on the E-Rate: Providing Schools and Libraries with Affordable Access to the Information Superhighway.

ERIC Educational Resources Information Center

Department of Education, Washington, DC. Office of Educational Technology.

This document provides a fact sheet, status report, and questions and answers about E-Rate, the discount Educational Rate that schools and libraries will receive for the acquisition of telecommunication services. E-Rate is the result of a regulatory decision on Universal Service made by the Federal Communications Commission (FCC) on May 7, 1997.…

Bio-sheet graft therapy for artificial gastric ulcer after endoscopic submucosal dissection: an animal feasibility study.

PubMed

Kwon, Chang-Il; Kim, Gwangil; Ko, Kwang Hyun; Jung, Yunho; Chung, Il-Kwun; Jeong, Seok; Lee, Don Haeng; Hong, Sung Pyo; Hahm, Ki Baik

2015-04-01

Various bio-sheet grafts have been attempted either to accelerate healing of artificial ulcers or to prevent adverse events after endoscopic submucosal dissection (ESD), but neither prospective nor mechanistic studies were available. To evaluate the substantial effect of a bio-sheet graft on artificial ulcer healing and its feasibility as an endoscopic treatment modality. Preclinical, in vivo animal experiment and proof-of-concept study. Animal laboratory. Three mini-pigs, Sus scrofa, mean age 14 months. Multiple ulcers sized 2.5 cm in diameter were generated by ESD in 3 mini-pigs and were assigned randomly into the following 3 groups; control group, bio-sheet group, or combination (bio-sheet plus drug) group. Bio-sheet grafts or bio-sheet plus drug combinations were applied on the artificial ulcers immediately after the ESD. Feasibility and efficacy of endoscopic bio-sheet graft therapy for the management of artificial ulcers and the evaluation of healing conditions based on histology changes in the remaining gastric bed tissues harvested from the stomachs. Thirty-three ESD specimens were obtained. On an image analysis of the ratio of healed area in the remaining gastric bed tissue compared with the matched dissected gastric mucosa, the control group showed the most significant improvement in healing activity among the 3 groups (P < .05), whereas the severity of inflammation in the remaining ulcer tissue was significantly attenuated in bio-sheet and combination groups (P < .05). Animal model. Although the bio-sheet grafts provided physical protection from gastric acid attack as reflected in the attenuated inflammation on the ulcer beds, unexpected delayed ulcer healing was noted in the bio-sheet graft group because of its physical hindrance of the healing process. Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

Modeling, Simulation, and Gaming: Student Capstone Conference

NASA Technical Reports Server (NTRS)

Banks, Catherine

2008-01-01

Highlights student research and student projects focused on MS&G. Competitive presentations - Volunteer judges from industry, government, military and academic institutions across America. - Evaluate research, presentation expertise, . and ability to answer questions. - Judges also facilitate their assigned conference tracks

Decision making in family medicine

PubMed Central

Labrecque, Michel; Ratté, Stéphane; Frémont, Pierre; Cauchon, Michel; Ouellet, Jérôme; Hogg, William; McGowan, Jessie; Gagnon, Marie-Pierre; Njoya, Merlin; Légaré, France

2013-01-01

Abstract Objective To compare the ability of users of 2 medical search engines, InfoClinique and the Trip database, to provide correct answers to clinical questions and to explore the perceived effects of the tools on the clinical decision-making process. Design Randomized trial. Setting Three family medicine units of the family medicine program of the Faculty of Medicine at Laval University in Quebec city, Que. Participants Fifteen second-year family medicine residents. Intervention Residents generated 30 structured questions about therapy or preventive treatment (2 questions per resident) based on clinical encounters. Using an Internet platform designed for the trial, each resident answered 20 of these questions (their own 2, plus 18 of the questions formulated by other residents, selected randomly) before and after searching for information with 1 of the 2 search engines. For each question, 5 residents were randomly assigned to begin their search with InfoClinique and 5 with the Trip database. Main outcome measures The ability of residents to provide correct answers to clinical questions using the search engines, as determined by third-party evaluation. After answering each question, participants completed a questionnaire to assess their perception of the engine’s effect on the decision-making process in clinical practice. Results Of 300 possible pairs of answers (1 answer before and 1 after the initial search), 254 (85%) were produced by 14 residents. Of these, 132 (52%) and 122 (48%) pairs of answers concerned questions that had been assigned an initial search with InfoClinique and the Trip database, respectively. Both engines produced an important and similar absolute increase in the proportion of correct answers after searching (26% to 62% for InfoClinique, for an increase of 36%; 24% to 63% for the Trip database, for an increase of 39%; P = .68). For all 30 clinical questions, at least 1 resident produced the correct answer after searching with either search engine. The mean (SD) time of the initial search for each question was 23.5 (7.6) minutes with InfoClinique and 22.3 (7.8) minutes with the Trip database (P = .30). Participants’ perceptions of each engine’s effect on the decision-making process were very positive and similar for both search engines. Conclusion Family medicine residents’ ability to provide correct answers to clinical questions increased dramatically and similarly with the use of both InfoClinique and the Trip database. These tools have strong potential to increase the quality of medical care. PMID:24130286

Decision making in family medicine: randomized trial of the effects of the InfoClinique and Trip database search engines.

PubMed

Labrecque, Michel; Ratté, Stéphane; Frémont, Pierre; Cauchon, Michel; Ouellet, Jérôme; Hogg, William; McGowan, Jessie; Gagnon, Marie-Pierre; Njoya, Merlin; Légaré, France

2013-10-01

To compare the ability of users of 2 medical search engines, InfoClinique and the Trip database, to provide correct answers to clinical questions and to explore the perceived effects of the tools on the clinical decision-making process. Randomized trial. Three family medicine units of the family medicine program of the Faculty of Medicine at Laval University in Quebec city, Que. Fifteen second-year family medicine residents. Residents generated 30 structured questions about therapy or preventive treatment (2 questions per resident) based on clinical encounters. Using an Internet platform designed for the trial, each resident answered 20 of these questions (their own 2, plus 18 of the questions formulated by other residents, selected randomly) before and after searching for information with 1 of the 2 search engines. For each question, 5 residents were randomly assigned to begin their search with InfoClinique and 5 with the Trip database. The ability of residents to provide correct answers to clinical questions using the search engines, as determined by third-party evaluation. After answering each question, participants completed a questionnaire to assess their perception of the engine's effect on the decision-making process in clinical practice. Of 300 possible pairs of answers (1 answer before and 1 after the initial search), 254 (85%) were produced by 14 residents. Of these, 132 (52%) and 122 (48%) pairs of answers concerned questions that had been assigned an initial search with InfoClinique and the Trip database, respectively. Both engines produced an important and similar absolute increase in the proportion of correct answers after searching (26% to 62% for InfoClinique, for an increase of 36%; 24% to 63% for the Trip database, for an increase of 39%; P = .68). For all 30 clinical questions, at least 1 resident produced the correct answer after searching with either search engine. The mean (SD) time of the initial search for each question was 23.5 (7.6) minutes with InfoClinique and 22.3 (7.8) minutes with the Trip database (P = .30). Participants' perceptions of each engine's effect on the decision-making process were very positive and similar for both search engines. Family medicine residents' ability to provide correct answers to clinical questions increased dramatically and similarly with the use of both InfoClinique and the Trip database. These tools have strong potential to increase the quality of medical care.

Questions and Answers About the Effects of Septic Systems on Water Quality in the La Pine Area, Oregon

USGS Publications Warehouse

Williams, John S.; Morgan, David S.; Hinkle, Stephen R.

2007-01-01

Nitrate levels in the ground-water aquifer underlying the central Oregon city of La Pine and the surrounding area are increasing due to contamination from residential septic systems. This contamination has public health implications because ground water is the sole source of drinking water for area residents. The U.S. Geological Survey, in cooperation with Deschutes County and the Oregon Department of Environmental Quality, studied the movement and chemistry of nitrate in the aquifer and developed computer models that can be used to predict future nitrate levels and to evaluate alternatives for protecting water quality. This fact sheet summarizes the results of that study in the form of questions and answers.

Validation of Welding Curriculum Manual.

ERIC Educational Resources Information Center

Stone, Sheila D.

A study was conducted to validate the welding curriculum materials developed and published by the Oklahoma State Department of Vocational and Technical Education. Twelve instructors collected achievement data (unit tests, assignment sheets, and evaluation forms) concerning the performance of 280 students on a total of 46 instructional units. Item…

Pediatric Online Evidence-Based Medicine Assignment Is a Novel Effective Enjoyable Undergraduate Medical Teaching Tool

PubMed Central

Kotb, Magd A.; Elmahdy, Hesham Nabeh; Khalifa, Nour El Deen Mahmoud; El-Deen, Mohamed Hamed Nasr; Lotfi, Mohamed Amr N.

2015-01-01

Abstract Evidence-based medicine (EBM) is delivered through a didactic, blended learning, and mixed models. Students are supposed to construct an answerable question in PICO (patient, intervention, comparison, and outcome) framework, acquire evidence through search of literature, appraise evidence, apply it to the clinical case scenario, and assess the evidence in relation to clinical context. Yet these teaching models have limitations especially those related to group work, for example, handling uncooperative students, students who fail to contribute, students who domineer, students who have personal conflict, their impact upon progress of their groups, and inconsistent individual acquisition of required skills. At Pediatrics Department, Faculty of Medicine, Cairo University, we designed a novel undergraduate pediatric EBM assignment online system to overcome shortcomings of previous didactic method and aimed to assess its effectiveness by prospective follow-up during academic years 2012 to 2013 and 2013 to 2014. The novel web-based online interactive system was tailored to provide sequential single and group assignments for each student. Single assignment addressed a specific case scenario question, while group assignment was teamwork that addressed different questions of same case scenario. Assignment comprised scholar content and skills. We objectively analyzed students’ performance by criterion-based assessment and subjectively by anonymous student questionnaire. A total of 2879 were enrolled in 5th year Pediatrics Course consecutively, of them 2779 (96.5%) logged in and 2554 (88.7%) submitted their work. They were randomly assigned to 292 groups. A total of 2277 (89.15%) achieved ≥80% of total mark (4/5), of them 717 (28.1%) achieved a full mark. A total of 2178 (85.27%) and 2359 (92.36%) made evidence-based conclusions and recommendations in single and group assignment, respectively (P < 0.001). A total of 1102 (43.1%) answered student questionnaire, of them 898 (81.48%) found e-educational experience satisfactory, 175 (15.88%) disagreed, and 29 (2.6%) could not decide. A total of 964 (87.47%) found single assignment educational, 913 (82.84%) found group assignment educational, and 794 (72.3%) enjoyed it. Web-based online interactive undergraduate EBM assignment was found effective in teaching medical students and assured individual student acquisition of concepts and skills of pediatric EMB. It was effective in mass education, data collection, and storage essential for system and student assessment. PMID:26200621

Pediatric Online Evidence-Based Medicine Assignment Is a Novel Effective Enjoyable Undergraduate Medical Teaching Tool: A SQUIRE Compliant Study.

PubMed

Kotb, Magd A; Elmahdy, Hesham Nabeh; Khalifa, Nour El Deen Mahmoud; El-Deen, Mohamed Hamed Nasr; Lotfi, Mohamed Amr N

2015-07-01

Evidence-based medicine (EBM) is delivered through a didactic, blended learning, and mixed models. Students are supposed to construct an answerable question in PICO (patient, intervention, comparison, and outcome) framework, acquire evidence through search of literature, appraise evidence, apply it to the clinical case scenario, and assess the evidence in relation to clinical context. Yet these teaching models have limitations especially those related to group work, for example, handling uncooperative students, students who fail to contribute, students who domineer, students who have personal conflict, their impact upon progress of their groups, and inconsistent individual acquisition of required skills. At Pediatrics Department, Faculty of Medicine, Cairo University, we designed a novel undergraduate pediatric EBM assignment online system to overcome shortcomings of previous didactic method and aimed to assess its effectiveness by prospective follow-up during academic years 2012 to 2013 and 2013 to 2014. The novel web-based online interactive system was tailored to provide sequential single and group assignments for each student. Single assignment addressed a specific case scenario question, while group assignment was teamwork that addressed different questions of same case scenario. Assignment comprised scholar content and skills. We objectively analyzed students' performance by criterion-based assessment and subjectively by anonymous student questionnaire. A total of 2879 were enrolled in 5th year Pediatrics Course consecutively, of them 2779 (96.5%) logged in and 2554 (88.7%) submitted their work. They were randomly assigned to 292 groups. A total of 2277 (89.15%) achieved ≥ 80% of total mark (4/5), of them 717 (28.1%) achieved a full mark. A total of 2178 (85.27%) and 2359 (92.36%) made evidence-based conclusions and recommendations in single and group assignment, respectively (P < 0.001). A total of 1102 (43.1%) answered student questionnaire, of them 898 (81.48%) found e-educational experience satisfactory, 175 (15.88%) disagreed, and 29 (2.6%) could not decide. A total of 964 (87.47%) found single assignment educational, 913 (82.84%) found group assignment educational, and 794 (72.3%) enjoyed it. Web-based online interactive undergraduate EBM assignment was found effective in teaching medical students and assured individual student acquisition of concepts and skills of pediatric EMB. It was effective in mass education, data collection, and storage essential for system and student assessment.

Prototypes of Cognitive Measures for Air Force Officers: Test Development and Item Banking

DTIC Science & Technology

1990-05-01

with the complexity of the relationship. Relationships may be in terms of shape, size, dimensionality, area of embeddedness , rotation, blank/shaded...administration were used. Test directions were read from the booklet. Demographics and test responses were recorded on a machine-scannable answer sheet...as demographic information would be needed to determine whether sample characteristics accounted for the differences in mean scores for NC, FA, and WD

ACER Mathematics Profile Series: Number Test. (Test Booklet, Answer and Record Sheet, Score Key, and Teachers Handbook).

ERIC Educational Resources Information Center

Cornish, Greg; Wines, Robin

The Number Test of the ACER Mathematics Profile Series, contains 30 items, for each of three suggested grade levels: 7-8, 8-9, and 9-10. Raw scores on all tests in the ACER Mathematics Profile Series (Number, Operations, Space and Measurement) are converted to a common scale called MAPS, a major feature of the Series. Based on the Rasch Model,…

Towards Greenland Glaciation: cumulative or abrupt transition?

NASA Astrophysics Data System (ADS)

Ramstein, Gilles; Tan, Ning; Ladant, Jean-baptiste; Dumas, Christophe; Contoux, Camille

2017-04-01

During the mid-Pliocene warming period (3-3.3 Ma BP), the global annual mean temperatures inferred by data and model studies were 2-3° warmer than pre-industrial values. Accordingly, Greenland ice sheet volume is supposed to reach at the most, only half of that of present-day [Haywood et al. 2010]. Around 2.7-2.6 Ma BP, just ˜ 500 kyr after the warming peak of mid-Pliocene, the Greenland ice sheet has reached its full size [Lunt et al. 2008]. A crucial question concerns the evolution of the Greenland ice sheet from half to full size during the 3 - 2.5 Ma period. Data show a decreasing trend of atmospheric CO2 concentration from 3 Ma to 2.5 Ma [Seki et al.2010; Bartoli et al. 2011; Martinez et al. 2015]. However, a recent study [Contoux et al. 2015] suggests that a lowering of CO2 is not sufficient to initiate a perennial glaciation on Greenland and must be combined with low summer insolation to preserve the ice sheet during insolation maxima. This suggests rather a cumulative process than an abrupt event. In order to diagnose the evolution of the ice sheet build-up, we carry on, for the first time, a transient simulation of climate and ice sheet evolutions from 3 Ma to 2.5 Ma. This strategy enables us to investigate the waxing and waning of the ice sheet during several orbital cycles. We use a tri-dimensional interpolation method designed by Ladant et al. (2014), which allows the evolution of CO2 concentration and of orbital parameters, and the evolution of the Greenland ice sheet size to be taken into account. By interpolating climatic snapshot simulations ran with various possible combinations of CO2, orbits and ice sheet sizes, we can build a continuous climatic forcing that is then used to provide 500 kyrs-long ice sheet simulations. With such a tool, we may offer a physically based answer to different CO2 reconstructions scenarios and analyse which one is the most consistent with Greenland ice sheet buildup.

Introduction to Natural Resources: Advanced Applications.

ERIC Educational Resources Information Center

Crummett, Dan

This guide, which is designed for use with student and teacher guides to a 10-unit secondary-level course in natural resources, contains a series of student supplements and advanced assignment and job sheets that provide students with additional opportunities to explore the following areas of natural resources and conservation education: outdoor…

Computer-Assisted Law Instruction: Clinical Education's Bionic Sibling

ERIC Educational Resources Information Center

Henn, Harry G.; Platt, Robert C.

1977-01-01

Computer-assisted instruction (CAI), like clinical education, has considerable potential for legal training. As an initial Cornell Law School experiment, a lesson in applying different corporate statutory dividend formulations, with a cross-section of balance sheets and other financial data, was used to supplement regular class assignments.…

Small Business Course for Older Americans. Student Handbook.

ERIC Educational Resources Information Center

American Association of Community and Junior Colleges, Washington, DC.

This student handbook was designed for a course which offers people aged 55 and older guidance in starting and operating a small business. Following introductory remarks concerning small businesses, information and assignment sheets related to each of the course's basic units are presented. Course units include the following: (1) Small Business…

Surgical Techniques. Second Edition. Teacher Edition.

ERIC Educational Resources Information Center

Bushey, Vicki; And Others

This instructor's manual contains 18 units of instruction for a course on surgical technology designed to include the entry-level competencies students need as a surgical technologist. Each unit includes some or all of the following basic components of a unit of instruction: objective sheet, suggested activities for the teacher, assignment sheets…

Intraoperative use of a reflective blanket (Sirius rescue sheet) for temperature management in dogs less than 10 kg.

PubMed

Tünsmeyer, J; Bojarski, I; Nolte, I; Kramer, S

2009-07-01

To compare the effects of the Sirius rescue sheet with gel pads versus gel pads alone on intraoperative body temperature in dogs less than 10 kg. Forty small breed dogs undergoing elective surgical procedures were randomly assigned to two groups. One group was intraoperatively laid on warmed gel pads, and the other group was additionally wrapped in a Sirius rescue sheet. Oesophageal body temperature was determined every 10 minutes and compared between groups. Temperature of gel pads was measured preoperatively and postoperatively to compare heat loss of the gel pads between groups. The body temperature of dogs wrapped with the Sirius rescue sheet increased intraoperatively. In dogs just lying on warmed gel pads, a decrease in mean body temperature was revealed and mean body temperatures differed between groups after 40 minutes. Extent of heat loss from the gel pads did not differ between the groups. The Sirius rescue sheet, used in addition to warmed gel pads, led to higher intraoperative body temperatures in small breed dogs undergoing surgical procedures to the extremities and the head. The cost-effectiveness and ease of handling make this a useful addition to clinical practice.

Using Case Studies to Promote Student Engagement in Primary Literature Data Analysis and Evaluation

PubMed Central

Cook-Snyder, Denise R.

2017-01-01

Analyzing and evaluating primary literature data is a common learning objective in undergraduate neuroscience courses. However, students with more clinically focused career goals often dismiss the relevance of evaluating basic neuroscience literature. Here, we describe using case studies to promote student engagement in primary literature in a cellular and molecular neuroscience course. Two example literature-based case studies are provided: Untwisting Pretzel Syndrome, a neurodevelopment case exploring synapse formation in a pretzel syndrome patient, and The Trials of ALS, a neurodegeneration case exploring axon degeneration and repair in an amyotrophic lateral sclerosis patient. These cases were assigned after neurodevelopment and neurodegeneration lectures covering key concepts. Both cases begin by introducing the patient and hypothesizing symptoms and diagnoses, followed by scenes incorporating primary data to illustrate disease pathogenesis and treatments. Students complete questions embedded in these cases as homework, and class time is used to discuss their answers. Discussion emphasizes that there can be multiple “correct” answers, and the best answers are accurate and well-supported. Accordingly, students edit their answers in class, and these annotations are factored into a pass/fail grade on the case. Additional scenes and questions from the same case studies are used on the course’s take-home exams, thereby allowing students to practice primary data analysis and evaluation before a graded assignment. Student evaluations support literature-based case studies as an effective learning tool, with students identifying cases as the most valuable aspect of the course, and reporting increased confidence in understanding cellular and molecular neuroscience. PMID:29371850

Using Case Studies to Promote Student Engagement in Primary Literature Data Analysis and Evaluation.

PubMed

Cook-Snyder, Denise R

2017-01-01

Analyzing and evaluating primary literature data is a common learning objective in undergraduate neuroscience courses. However, students with more clinically focused career goals often dismiss the relevance of evaluating basic neuroscience literature. Here, we describe using case studies to promote student engagement in primary literature in a cellular and molecular neuroscience course. Two example literature-based case studies are provided: Untwisting Pretzel Syndrome, a neurodevelopment case exploring synapse formation in a pretzel syndrome patient, and The Trials of ALS, a neurodegeneration case exploring axon degeneration and repair in an amyotrophic lateral sclerosis patient. These cases were assigned after neurodevelopment and neurodegeneration lectures covering key concepts. Both cases begin by introducing the patient and hypothesizing symptoms and diagnoses, followed by scenes incorporating primary data to illustrate disease pathogenesis and treatments. Students complete questions embedded in these cases as homework, and class time is used to discuss their answers. Discussion emphasizes that there can be multiple "correct" answers, and the best answers are accurate and well-supported. Accordingly, students edit their answers in class, and these annotations are factored into a pass/fail grade on the case. Additional scenes and questions from the same case studies are used on the course's take-home exams, thereby allowing students to practice primary data analysis and evaluation before a graded assignment. Student evaluations support literature-based case studies as an effective learning tool, with students identifying cases as the most valuable aspect of the course, and reporting increased confidence in understanding cellular and molecular neuroscience.

Where can I get help with science questions?

Atmospheric Science Data Center

2014-12-08

... (ASDC's) User Services. They will forward them to the volunteer scientists assigned to the ERBE data sets. Since the ERBE project has ... is very limited and depends on the availability of our volunteer scientists. It may take a few days to receive your answers. ...

Measuring Discrimination in Education. NBER Working Paper No. 15057

ERIC Educational Resources Information Center

Hanna, Rema; Linden. Leigh

2009-01-01

In this paper, we illustrate a methodology to measure discrimination in educational contexts. In India, we ran an exam competition through which children compete for a large financial prize. We recruited teachers to grade the exams. We then randomly assigned child "characteristics" (age, gender, and caste) to the cover sheets of the…

The Effects of a Computerized Study Program on the Acquisition of Science Vocabulary

ERIC Educational Resources Information Center

Rollins, Karen F.

2012-01-01

The following study examined the difference in science vocabulary acquisition comparing computer-assisted learning and a traditional study review sheet. Fourth and fifth grade students from a suburban school in central Texas were randomly selected and randomly assigned to either experimental group or control group. Both groups were given a…

40 CFR 370.42 - What is Tier II inventory information?

Code of Federal Regulations, 2013 CFR

2013-07-01

... common name of the chemical as provided on the Material Safety Data Sheet and its Chemical Abstract....64(a). (2) Indicate whether the chemical is: pure or mixture; solid, liquid, or gas; and whether the... Inventory (TRI) and Risk Management Program. If your facility has not been assigned an identification number...

Exploring Norms and Moral Authority through Content Analysis of Classic Texts.

ERIC Educational Resources Information Center

Wallace, Richard Cheever

1993-01-01

Describes a class assignment for a college-level sociology course in which students read from religious texts to identify norms and sanctions. Reports that students expressed positive comments about the activity. Includes suggestions for preparing materials, instructions for implementing the activity, and a coding sheet to be used by students.…

Thermal analysis and vibrational spectroscopic characterization of the boro silicate mineral datolite - CaBSiO4(OH)

NASA Astrophysics Data System (ADS)

Frost, Ray L.; Xi, Yunfei; Scholz, Ricardo; Lima, Rosa Malena Fernandes; Horta, Laura Frota Campos; Lopez, Andres

2013-11-01

The objective of this work is to determine the thermal stability and vibrational spectra of datolite CaBSiO4(OH) and relate these properties to the structure of the mineral. The thermal analysis of datolite shows a mass loss of 5.83% over a 700-775 °C temperature range. This mass loss corresponds to 1 water (H2O) molecules pfu. A quantitative chemical analysis using electron probe was undertaken. The Raman spectrum of datolite is characterized by bands at 917 and 1077 cm-1 assigned to the symmetric stretching modes of BO and SiO tetrahedra. A very intense Raman band is observed at 3498 cm-1 assigned to the stretching vibration of the OH units in the structure of datolite. BOH out-of-plane vibrations are characterized by the infrared band at 782 cm-1. The vibrational spectra are based upon the structure of datolite based on sheets of four- and eight-membered rings of alternating SiO4 and BO3(OH) tetrahedra with the sheets bonded together by calcium atoms.

Incorporation of ice sheet models into an Earth system model: Focus on methodology of coupling

NASA Astrophysics Data System (ADS)

Rybak, Oleg; Volodin, Evgeny; Morozova, Polina; Nevecherja, Artiom

2018-03-01

Elaboration of a modern Earth system model (ESM) requires incorporation of ice sheet dynamics. Coupling of an ice sheet model (ICM) to an AOGCM is complicated by essential differences in spatial and temporal scales of cryospheric, atmospheric and oceanic components. To overcome this difficulty, we apply two different approaches for the incorporation of ice sheets into an ESM. Coupling of the Antarctic ice sheet model (AISM) to the AOGCM is accomplished via using procedures of resampling, interpolation and assigning to the AISM grid points annually averaged meanings of air surface temperature and precipitation fields generated by the AOGCM. Surface melting, which takes place mainly on the margins of the Antarctic peninsula and on ice shelves fringing the continent, is currently ignored. AISM returns anomalies of surface topography back to the AOGCM. To couple the Greenland ice sheet model (GrISM) to the AOGCM, we use a simple buffer energy- and water-balance model (EWBM-G) to account for orographically-driven precipitation and other sub-grid AOGCM-generated quantities. The output of the EWBM-G consists of surface mass balance and air surface temperature to force the GrISM, and freshwater run-off to force thermohaline circulation in the oceanic block of the AOGCM. Because of a rather complex coupling procedure of GrIS compared to AIS, the paper mostly focuses on Greenland.

Callosobruchus maculatus: A Seed Beetle with a Future in Schools.

ERIC Educational Resources Information Center

Dockery, Michael

1997-01-01

Recommends the use of seed beetles for studying animal behavior and provides suggestions for practical and project assignments. Sources for obtaining the beetles and a list of the equipment needed for their study and maintenance are provided. Answers to common concerns are addressed. (DDR)

The Paradoxical Value of Privacy

DTIC Science & Technology

2003-03-14

on occurrence of identity theft correlated with consumer behavior so that probabilities of at least such clear privacy problems could be assigned to...now. And, the market typically needs to learn from experience, so consumer behavior is likely to lag behind any current reality. So one answer is that

Doing REAL History: Citing Your Mother in Your Research Paper.

ERIC Educational Resources Information Center

Libresco, Andrew S.

2001-01-01

Describes a project for high school students where the students write research papers that incorporate oral history interviews. Provides a list of questions students can answer and excerpts from students' research papers. Discusses which National Council for the Social Studies standards the assignment addresses. (CMK)

Results of a round-robin exercise on read-across.

PubMed

Benfenati, E; Belli, M; Borges, T; Casimiro, E; Cester, J; Fernandez, A; Gini, G; Honma, M; Kinzl, M; Knauf, R; Manganaro, A; Mombelli, E; Petoumenou, M I; Paparella, M; Paris, P; Raitano, G

2016-05-01

A round-robin exercise was conducted within the CALEIDOS LIFE project. The participants were invited to assess the hazard posed by a substance, applying in silico methods and read-across approaches. The exercise was based on three endpoints: mutagenicity, bioconcentration factor and fish acute toxicity. Nine chemicals were assigned for each endpoint and the participants were invited to complete a specific questionnaire communicating their conclusions. The interesting aspect of this exercise is the justification behind the answers more than the final prediction in itself. Which tools were used? How did the approach selected affect the final answer?

Intrinsic Dawn-Dusk Asymmetry of Magnetotail Thin Current Sheet

NASA Astrophysics Data System (ADS)

Lu, S.; Pritchett, P. L.; Angelopoulos, V.; Artemyev, A.

2017-12-01

Magnetic reconnection and its related phenomena (flux ropes, dipolarization fronts, bursty bulk flows, particle injections, etc.) occur more frequently on the duskside in the Earth's magnetotail. Magnetohydrodynamic simulations attributed the asymmetry to the nonuniform ionospheric conductance through global scale magnetosphere-ionosphere interaction. Hybrid simulations, on the other hand, found an alternative responsible mechanism: the Hall effect in the magnetotail thin current sheet, but left an open question: What is the physical origin of the asymmetric Hall effect? The answer could be the temperature difference on the two sides and/or the dawn-dusk transportation of magnetic flux and plasmas. In this work, we use 3-D particle-in-cell simulations to further explore the magnetotail dawn-dusk asymmetry. The magnetotail equilibrium contains a dipole magnetic field and a current sheet region. The simulation is driven by a symmetric and localized (in the y direction) high-latitude electric field, under which the current sheet thins with a decrease of Bz. During the same time, a dawn-dusk asymmetry is formed intrinsically in the thin current sheet, with a smaller Bz, a stronger Hall effect (indicated by the Hall electric field Ez), and a stronger cross-tail current jy on the duskside. The deep origin of the asymmetry is also shown to be dominated by the dawnward E×B drift of magnetic flux and plasmas. A direct consequence of this intrinsic dawn-dusk asymmetry is that it favors magnetotail reconnection and related phenomena to preferentially occur on the duskside.

A New Secondary Structure Assignment Algorithm Using Cα Backbone Fragments

PubMed Central

Cao, Chen; Wang, Guishen; Liu, An; Xu, Shutan; Wang, Lincong; Zou, Shuxue

2016-01-01

The assignment of secondary structure elements in proteins is a key step in the analysis of their structures and functions. We have developed an algorithm, SACF (secondary structure assignment based on Cα fragments), for secondary structure element (SSE) assignment based on the alignment of Cα backbone fragments with central poses derived by clustering known SSE fragments. The assignment algorithm consists of three steps: First, the outlier fragments on known SSEs are detected. Next, the remaining fragments are clustered to obtain the central fragments for each cluster. Finally, the central fragments are used as a template to make assignments. Following a large-scale comparison of 11 secondary structure assignment methods, SACF, KAKSI and PROSS are found to have similar agreement with DSSP, while PCASSO agrees with DSSP best. SACF and PCASSO show preference to reducing residues in N and C cap regions, whereas KAKSI, P-SEA and SEGNO tend to add residues to the terminals when DSSP assignment is taken as standard. Moreover, our algorithm is able to assign subtle helices (310-helix, π-helix and left-handed helix) and make uniform assignments, as well as to detect rare SSEs in β-sheets or long helices as outlier fragments from other programs. The structural uniformity should be useful for protein structure classification and prediction, while outlier fragments underlie the structure–function relationship. PMID:26978354

A Study of False-Positive and False-Negative Error Rates in Cartridge Case Comparisons

DTIC Science & Technology

2014-04-07

materials for the study, in particular Vicki Sieve. 3 Abstract: This report provides the details for a study designed to...participate in ASCLD were provided with 15 sets of 3 known + 1 unknown cartridge cases fired from a collection of 25 new Ruger SR9 handguns . The...answer sheet allowing for the AFTE range of conclusions, and return shipping materials . They were also asked to assess how many of the 3 knowns were

Anatomy of a Book Controversy.

ERIC Educational Resources Information Center

Homstad, Wayne

A major controversy arose in 1987 in a midwestern school district, after a middle school teacher assigned the novel "Go Ask Alice" to her seventh-grade class. This book describes the district's attempt to answer two basic questions: What should students read? and Who should decide what students read? The book controversy is first…

Making Molecular Movies

ERIC Educational Resources Information Center

O'Brien, Walter

2015-01-01

One of the most difficult challenges of incorporating literacy in the classroom--as called for by the "Common Core State Standards" (NGAC and CCSSO 2010)--is inspiring reluctant writers. Students are often unmotivated by essay assignments or having to write answers to open-ended questions. Some students may even view these as obstacles…

Learning to Read Empirical Articles in General Psychology

ERIC Educational Resources Information Center

Sego, Sandra A.; Stuart, Anne E.

2016-01-01

Many students, particularly underprepared students, struggle to identify the essential information in empirical articles. We describe a set of assignments for instructing general psychology students to dissect the structure of such articles. Students in General Psychology I read empirical articles and answered a set of general, factual questions…

Modelling Cognitive Style in a Peer Help Network.

ERIC Educational Resources Information Center

Bull, Susan; McCalla, Gord

2002-01-01

Explains I-Help, a computer-based peer help network where students can ask and answer questions about assignments and courses based on the metaphor of a help desk. Highlights include cognitive style; user modeling in I-Help; matching helpers to helpees; and types of questions. (Contains 64 references.) (LRW)

Word Search Packet: Climbing the Hills of Math Skills. California Demonstration Mathematics Program.

ERIC Educational Resources Information Center

Ontario-Montclair School District, Ontario, CA.

Thirty word-search puzzles on mathematics and mathematicians are presented. The puzzles are used periodically as homework assignments in a self-paced, individualized mathematics program which is designed to improve the achievement of junior high school students. Answers to the puzzles are not included. (DC)

Categorising Motivational Drives in Second Language Acquisition.

ERIC Educational Resources Information Center

Green, Christopher Frank

1999-01-01

Studied learning motivation of English by Cantonese-speaking students in Hong Kong. Students answered a questionnaire and were assigned on the basis of their responses to four categories of motivational regulation proposed in Deci and Ryan (1985): External, Identified, and Integrated. Suggests that the transition from Identified to Integrated…

A Tale of Four Electrons

ERIC Educational Resources Information Center

Burgmayer, Paul

2011-01-01

"A Tale of Four Electrons" is a creative writing assignment used with 10th-grade Honors Chemistry students. The project helps students consolidate their learning about bonding--an important unifying theme in chemistry--and answers questions such as (1) How are ionic, metallic, and covalent bonds related? (2) How do variations in electron…

Crime in the Classroom Part IV: Conclusions

ERIC Educational Resources Information Center

Harpp, David N.

2008-01-01

In 1990, the McGill University Senate established regulations governing how multiple-choice exams are to be conducted. The primary rules require multiple-version exams (scrambled question and if possible, scrambled answer positions) as well as assigned seating or seating with alternating rows of students from different courses. In recent years, we…

The Art of Science Writing.

ERIC Educational Resources Information Center

Worsley, Dale; Mayer, Bernadette

Aimed at secondary school science and English teachers, this book presents practical advice for developing good student writing in science and mathematics. Five main sections cover: (1) an essay development workshop; (2) 47 specific writing assignments; (3) over 30 questions teachers ask about science writing, and the answers; (4) an anthology of…

College Libraries and Student Culture: What We Now Know

ERIC Educational Resources Information Center

Duke, Lynda M., Ed.; Asher, Andrew D., Ed.

2012-01-01

How do college students "really" conduct research for classroom assignments? In 2008, five large Illinois universities were awarded a Library Services and Technology Act Grant to try to answer that question. The resulting ongoing study has already yielded some eye-opening results. The findings suggest changes ranging from simple…

Balancing Content & Language in the English Language Development Classroom

ERIC Educational Resources Information Center

Reynolds-Young, Danielle; Hood, Sally

2014-01-01

Although course assignments require English as a Second Language (ESL) teacher candidates to design activities, performance assessments, and lessons that balance the teaching of the English language and academic content, the ESL teacher candidates remain perplexed as to how to teach without a prescribed curriculum. The answer is challenging, given…

Understanding by the general public of newspaper reports on publicly reported cancer survival in Japan: a randomized controlled trial.

PubMed

Nakamura, Fumiaki; Higashi, Takahiro; Saruki, Nobuhiro; Fukuhara, Shunichi; Sobue, Tomotaka

2014-07-01

This study was aimed to examine how well readers of newspapers understand cancer survival rate data, and the effect of this understanding on their behavioral intent. We recruited 1950 persons who were 20 years old or older registered with a market research company. Participants were randomly divided into 10 groups; 9 were assigned one of nine newspaper articles, and the remaining group was assigned the excerpt of the official Association of Clinical Cancer Centers web pages. The primary outcome was the proportion of respondents with 'sufficient understanding', who gave 70% or more correct answers on a 10-item knowledge question. The proportion of participants with sufficient understanding varied across the groups (range: 0.8-22.1%, overall, P<0.001). Only around 15% of participants answered that they would consider other hospitals in a scenario where the only hospital in the participants' area had a 5-year survival of 5% or less, and answers did not significantly vary between groups (range: 11.1-21.0%, overall P=0.77). The level of understanding of cancer survival rate varied by variation in media reporting. However, the effect of behavioral intent on hospital choice did not differ between articles. UMIN CTR UMIN000004885. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Climbing Bloom's taxonomy pyramid: Lessons from a graduate histology course.

PubMed

Zaidi, Nikki B; Hwang, Charles; Scott, Sara; Stallard, Stefanie; Purkiss, Joel; Hortsch, Michael

2017-09-01

Bloom's taxonomy was adopted to create a subject-specific scoring tool for histology multiple-choice questions (MCQs). This Bloom's Taxonomy Histology Tool (BTHT) was used to analyze teacher- and student-generated quiz and examination questions from a graduate level histology course. Multiple-choice questions using histological images were generally assigned a higher BTHT level than simple text questions. The type of microscopy technique (light or electron microscopy) used for these image-based questions did not result in any significant differences in their Bloom's taxonomy scores. The BTHT levels for teacher-generated MCQs correlated positively with higher discrimination indices and inversely with the percent of students answering these questions correctly (difficulty index), suggesting that higher-level Bloom's taxonomy questions differentiate well between higher- and lower-performing students. When examining BTHT scores for MCQs that were written by students in a Multiple-Choice Item Development Assignment (MCIDA) there was no significant correlation between these scores and the students' ability to answer teacher-generated MCQs. This suggests that the ability to answer histology MCQs relies on a different skill set than the aptitude to construct higher-level Bloom's taxonomy questions. However, students significantly improved their average BTHT scores from the midterm to the final MCIDA task, which indicates that practice, experience and feedback increased their MCQ writing proficiency. Anat Sci Educ 10: 456-464. © 2017 American Association of Anatomists. © 2017 American Association of Anatomists.

Which factors predict the time spent answering queries to a drug information centre?

PubMed Central

Reppe, Linda A.; Spigset, Olav

2010-01-01

Objective To develop a model based upon factors able to predict the time spent answering drug-related queries to Norwegian drug information centres (DICs). Setting and method Drug-related queries received at 5 DICs in Norway from March to May 2007 were randomly assigned to 20 employees until each of them had answered a minimum of five queries. The employees reported the number of drugs involved, the type of literature search performed, and whether the queries were considered judgmental or not, using a specifically developed scoring system. Main outcome measures The scores of these three factors were added together to define a workload score for each query. Workload and its individual factors were subsequently related to the measured time spent answering the queries by simple or multiple linear regression analyses. Results Ninety-six query/answer pairs were analyzed. Workload significantly predicted the time spent answering the queries (adjusted R2 = 0.22, P < 0.001). Literature search was the individual factor best predicting the time spent answering the queries (adjusted R2 = 0.17, P < 0.001), and this variable also contributed the most in the multiple regression analyses. Conclusion The most important workload factor predicting the time spent handling the queries in this study was the type of literature search that had to be performed. The categorisation of queries as judgmental or not, also affected the time spent answering the queries. The number of drugs involved did not significantly influence the time spent answering drug information queries. PMID:20922480

A monograph assignment as an integrative application of evidence-based medicine and pharmacoeconomic principles.

PubMed

Law, Anandi V; Jackevicius, Cynthia A; Bounthavong, Mark

2011-02-10

To describe the development and assessment of monographs as an assignment to incorporate evidence-based medicine (EBM) and pharmacoeconomic principles into a third-year pharmacoeconomic course. Eight newly FDA-approved drugs were assigned to 16 teams of students, where each drug was assigned to 2 teams. Teams had to research their drug, write a professional monograph, deliver an oral presentation, and answer questions posed by faculty judges. One team was asked to present evidence for inclusion of the drug into a formulary, while another team presented evidence against inclusion. The teams' average score on the written report was 99.1%; on the oral presentation, 92.5%, and on the online quiz given at the end of the presentations, 77%. Monographs are a successful method of incorporating and integrating learning across different concepts, as well as increasing relevance of pharmacoeconomics in the PharmD curriculum.

A Monograph Assignment as an Integrative Application of Evidence-Based Medicine and Pharmacoeconomic Principles

PubMed Central

Jackevicius, Cynthia A.; Bounthavong, Mark

2011-01-01

Objective To describe the development and assessment of monographs as an assignment to incorporate evidence-based medicine (EBM) and pharmacoeconomic principles into a third-year pharmacoeconomic course. Design Eight newly FDA-approved drugs were assigned to 16 teams of students, where each drug was assigned to 2 teams. Teams had to research their drug, write a professional monograph, deliver an oral presentation, and answer questions posed by faculty judges. One team was asked to present evidence for inclusion of the drug into a formulary, while another team presented evidence against inclusion. Assessment The teams' average score on the written report was 99.1%; on the oral presentation, 92.5%, and on the online quiz given at the end of the presentations, 77%. Conclusions Monographs are a successful method of incorporating and integrating learning across different concepts, as well as increasing relevance of pharmacoeconomics in the PharmD curriculum. PMID:21451753

Valuing Exercises for the Middle School. Resource Monograph No. 11.

ERIC Educational Resources Information Center

Casteel, J. Doyle; And Others

One of the major goals of the middle school is to help students gain and refine skills in the area of values clarification. One way of securing such value clarification is to plan and assign value sheets--carefully planned and written activities designed to elicit value clarification patterns of language usage from students. Six different formats…

Military Curriculum Materials for Vocational and Technical Education. Fundamentals of Electricity, 3-7.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This self-paced correspondence course for independent study in electricity was adapted from military curriculum materials for use in vocational education. This basic course is designed to provide the student with some fundamentals of electricity--not with specific job skills. The seven lessons of the course each have a lesson assignment sheet with…

On the problem of resonance assignments in solid state NMR of uniformly 15N, 13C-labeled proteins

NASA Astrophysics Data System (ADS)

Tycko, Robert

2015-04-01

Determination of accurate resonance assignments from multidimensional chemical shift correlation spectra is one of the major problems in biomolecular solid state NMR, particularly for relative large proteins with less-than-ideal NMR linewidths. This article investigates the difficulty of resonance assignment, using a computational Monte Carlo/simulated annealing (MCSA) algorithm to search for assignments from artificial three-dimensional spectra that are constructed from the reported isotropic 15N and 13C chemical shifts of two proteins whose structures have been determined by solution NMR methods. The results demonstrate how assignment simulations can provide new insights into factors that affect the assignment process, which can then help guide the design of experimental strategies. Specifically, simulations are performed for the catalytic domain of SrtC (147 residues, primarily β-sheet secondary structure) and the N-terminal domain of MLKL (166 residues, primarily α-helical secondary structure). Assuming unambiguous residue-type assignments and four ideal three-dimensional data sets (NCACX, NCOCX, CONCA, and CANCA), uncertainties in chemical shifts must be less than 0.4 ppm for assignments for SrtC to be unique, and less than 0.2 ppm for MLKL. Eliminating CANCA data has no significant effect, but additionally eliminating CONCA data leads to more stringent requirements for chemical shift precision. Introducing moderate ambiguities in residue-type assignments does not have a significant effect.

Learning in depth with the bespoke rubric-supported online poster presentation

NASA Astrophysics Data System (ADS)

Lajevardipour, Alireza; Wood, Andrew

2017-08-01

In our course of Biomedical Imaging, we introduced a research project as an assignment that included an online poster presentation. To assess the assignment, an adjusted criteria sheet was created, where it facilitated providing students with an effective feedback linked to particular criteria. Students are expected to produce a scientific poster to present the result of their investigation and upload it to an online discussion board. In addition, they are required to read their colleagues' works and provide peer-feedback by asking quality questions about principles and results, also on-line. Subtle distribution of marks in the rubric balances focus between preparing poster and providing peer-feedbacks.

Simulating Heinrich events in a coupled atmosphere-ocean-ice sheet model

NASA Astrophysics Data System (ADS)

Mikolajewicz, Uwe; Ziemen, Florian

2016-04-01

Heinrich events are among the most prominent events of long-term climate variability recorded in proxies across the northern hemisphere. They are the archetype of ice sheet - climate interactions on millennial time scales. Nevertheless, the exact mechanisms that cause Heinrich events are still under discussion, and their climatic consequences are far from being fully understood. We contribute to answering the open questions by studying Heinrich events in a coupled ice sheet model (ISM) atmosphere-ocean-vegetation general circulation model (AOVGCM) framework, where this variability occurs as part of the model generated internal variability without the need to prescribe external perturbations, as was the standard approach in almost all model studies so far. The setup consists of a northern hemisphere setup of the modified Parallel Ice Sheet Model (mPISM) coupled to the global coarse resolution AOVGCM ECHAM5/MPIOM/LPJ. The simulations used for this analysis were an ensemble covering substantial parts of the late Glacial forced with transient insolation and prescribed atmospheric greenhouse gas concentrations. The modeled Heinrich events show a marked influence of the ice discharge on the Atlantic circulation and heat transport, but none of the Heinrich events during the Glacial did show a complete collapse of the North Atlantic meridional overturning circulation. The simulated main consequences of the Heinrich events are a freshening and cooling over the North Atlantic and a drying over northern Europe.

Recalling Prerequisite Material in a Calculus II Course to Improve Student Success

ERIC Educational Resources Information Center

Mokry, Jeanette

2016-01-01

This article discusses preparation assignments used in a Calculus II course that cover material from prerequisite courses. Prior to learning new material, students work on problems outside of class involving concepts from algebra, trigonometry, and Calculus I. These problems are directly built upon in order to answer Calculus II questions,…

Generic Assessment Rubrics for Computer Programming Courses

ERIC Educational Resources Information Center

Mustapha, Aida; Samsudin, Noor Azah; Arbaiy, Nurieze; Mohammed, Rozlini; Hamid, Isredza Rahmi

2016-01-01

In programming, one problem can usually be solved using different logics and constructs but still producing the same output. Sometimes students get marked down inappropriately if their solutions do not follow the answer scheme. In addition, lab exercises and programming assignments are not necessary graded by the instructors but most of the time…

The Economic Naturalist Writing Assignment

ERIC Educational Resources Information Center

Frank, Robert H.

2006-01-01

Several months after having completed an introductory economics course, most students are no better able to answer simple economic questions than students who never took the course. The problem seems to be that principles courses try to teach students far too much, with the result that everything goes by in a blur. The good news is that a…

Arithmetic Practice Can Be Modified to Promote Understanding of Mathematical Equivalence

ERIC Educational Resources Information Center

McNeil, Nicole M.; Fyfe, Emily R.; Dunwiddie, April E.

2015-01-01

This experiment tested if a modified version of arithmetic practice facilitates understanding of math equivalence. Children within 2nd-grade classrooms (N = 166) were randomly assigned to practice single-digit addition facts using 1 of 2 workbooks. In the control workbook, problems were presented in the traditional "operations = answer"…

Aircraft Electrical Repairman Technician, 2-2. Military Curriculum Materials for Vocational and Technical Education.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

These military-developed curriculum materials consist of a volume of text information; a student workbook containing objectives, reading assignments, chapter review exercises, and answers; a volume review exercise; and two illustration booklets for use with the student exercises. Covered in the course are the following topics: use and maintenance…

Poster Presentations: An Alternative to the Traditional Classroom Lecture.

ERIC Educational Resources Information Center

Hunter, Kimberly A.

1997-01-01

In a doctoral pharmacy course, student pairs were assigned presentations on topics related to specific anemias or blood disorders, and given one-and-a-half hours to present the material, with posters as visual aids, and to answer questions. The method is seen as promoting active learning, critical thinking, and professional presentation skills,…

Web-Based Trainer for Electrical Circuit Analysis

ERIC Educational Resources Information Center

Weyten, L.; Rombouts, P.; De Maeyer, J.

2009-01-01

A Web-based system for training electric circuit analysis is presented in this paper. It is centered on symbolic analysis techniques and it not only verifies the student's final answer, but it also tracks and coaches him/her through all steps of his/her reasoning path. The system mimics homework assignments, enhanced by immediate personalized…

COMPUTER TECHNIQUES FOR WEEKLY MULTIPLE-CHOICE TESTING.

ERIC Educational Resources Information Center

BROYLES, DAVID

TO ENCOURAGE POLITICAL SCIENCE STUDENTS TO READ PROPERLY AND CONTINUOUSLY, THE AUTHOR GIVES FREQUENT SHORT QUIZZES BASED ON THE ASSIGNED READINGS. FOR EASE IN ADMINISTRATION AND SCORING, HE USES MARK-SENSE CARDS, ON WHICH THE STUDENT MARKS DESIGNATED AREAS TO INDICATE HIS NUMBER AND HIS CHOICE OF ANSWERS. TO EMPHASIZE THE VALUE OF CONTINUED HIGH…

Going Metric...PAL (Programmed Assigned Learning).

ERIC Educational Resources Information Center

Wallace, Jesse D.

This 41-page programed booklet is intended for use by students and adults. It introduces the metric units for length, area, volume, and temperature through a series of questions and answers. The advantages of the metric system over the English system are discussed. Conversion factors are introduced and several applications of the metric system in…

Current Issues and Problems in Texas Community Colleges.

ERIC Educational Resources Information Center

Hastings, Chester R., Comp.

In October 1992, doctoral students enrolled in a community college leadership program at Baylor University in Waco, Texas, were assigned six questions to be answered in collaboration with the Chief Executive Officer (CEO), or the CEO's designate, at the 15 community colleges where the students were employed. The questions explored respondents'…

Effects of Enhanced Anchored Instruction on Skills Aligned to Common Core Math Standards

ERIC Educational Resources Information Center

Bottge, Brian A.; Cho, Sun-Joo

2013-01-01

This study compared how students with learning difficulties in math (MLD) who were randomly assigned to two instructional conditions answered items on problem solving tests aligned to the Common Core State Standards Initiative for Mathematics. Posttest scores showed improvement in the math performance of students receiving Enhanced Anchored…

75 FR 61166 - Delegation and Redelegation of Authority for the Office of the Inspector General

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... of authority of the Office of Inspector General to require by subpoena the production of all information, documents, reports, answers, records, accounts, papers, and other data in any medium (including... performance of the functions assigned by the Inspector General Act to the Deputy Inspector General, the...

Observing and Deterring Social Cheating on College Exams

ERIC Educational Resources Information Center

Fendler, Richard J.; Yates, Michael C.; Godbey, Johnathan M.

2018-01-01

This research introduces a unique multiple choice exam design to observe and measure the degree to which students copy answers from their peers. Using data collected from the exam, an empirical experiment is conducted to determine whether random seat assignment deters cheating relative to a control group of students allowed to choose their seats.…

Sequence-specific sup 1 H NMR resonance assignments of Bacillus subtilis HPr: Use of spectra obtained from mutants to resolve spectral overlap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wittekind, M.; Klevit, R.E.; Reizer, J.

1990-08-07

On the basis of an analysis of two-dimensional {sup 1}H NMR spectra, the complete sequence-specific {sup 1}H NMR assignments are presented for the phosphocarrier protein HPr from the Gram-positive bacterium Bacillus subtilis. During the assignment procedure, extensive use was made of spectra obtained from point mutants of HPr in order to resolve spectral overlap and to provide verification of assignments. Regions of regular secondary structure were identified by characteristic patterns of sequential backbone proton NOEs and slowly exchanging amide protons. B subtilis HPr contains four {beta}-strands that form a single antiparallel {beta}-sheet and two well-defined {alpha}-helices. There are two stretchesmore » of extended backbone structure, one of which contains the active site His{sub 15}. The overall fold of the protein is very similar to that of Escherichia coli HPr determined by NMR studies.« less

A Modern Approach to the Traditional Textbook: Bringing Introductory Geology Courses into the 21st Century

NASA Astrophysics Data System (ADS)

Workman Ford, K.; Ford, K. R.

2013-12-01

Undergraduate introductory geology courses are required in many colleges nationwide as part of the general education requirement. As a result, a large portion of those students are non-majors and most are not science majors. Textbooks used in these courses are often extensive with respect to the amount of material covered which tends to be overwhelming to the average student. Thus, students often purchase the pricey textbook but turn to their smartphones, notebooks, and laptops for answers. Before the development of the internet, students spent many hours in libraries and with their textbooks organizing and retrieving information. However, new technologies in the 21st century have essentially replaced traditional textbooks with students turning to online search engines, such as Google, to study and to complete homework assignments. Presently, online search engines may be more intuitive, but what's going on in the background isn't intuitive at all, and few students have a clear understanding of how search engines operate. Effectively this leads to students without the conception of how to build an adequate search strategy independent of search engines. Often, students are directed to online encyclopedias that may have erroneous information. Here, we employ an alternative to traditional textbooks and online search engines by implementing a guidebook with electronic resources for online activities and homework assignments. The proposed guidebook is roughly modeled after the American Geosciences Institute's Geoscience Handbook: AGI Data Sheets 4th, revised edition, and will include diagrams, graphs, charts, and pictures of basic geologic principles, processes, and earth materials. Along with the information, each topic will have online resources including sites for general reading, specific assignments that require visiting scientifically sound websites (i.e., USGS, GSA, AGU, Science, Nature), online self-assessment activities, and Google Earth activities. In addition, some elements would include a critical thinking problem wherein students research a topic without specific online resources provided, and compare what they find to reputable resources. This process is likely to drive students to evaluate their sources in a more critical manner. Given that textbooks are costly and sometimes overwhelming for students compelling them to use online search engines, the idea of a guidebook that encompasses electronic resources may engage the students more effectively, leading to a more comprehensive understanding and appreciation of the geosciences.

Process Mechanics Analysis in Single Point Incremental Forming

NASA Astrophysics Data System (ADS)

Ambrogio, G.; Filice, L.; Fratini, L.; Micari, F.

2004-06-01

The request of highly differentiated products and the need of process flexibility have brought the researchers to focus the attention on innovative sheet forming processes. Industrial application of conventional processes is, in fact, economically convenient just for large scale productions; furthermore conventional processes do not allow to fully satisfy the mentioned demand of flexibility. In this contest, single point incremental forming (SPIF) is an innovative and flexible answer to market requests. The process is characterized by a peculiar process mechanics, being the sheet plastically deformed only through a localised stretching mechanism. Some recent experimental studies have shown that SPIF permits a relevant increase of formability limits, just as a consequence of the peculiar deformation mechanics. The research here addressed is focused on the theoretical investigation of process mechanics; the aim was to achieve a deeper understanding of basic phenomena involved in SPIF which justify the above mentioned formability enhancing.

The Impact of Adding Online Homework Assignments to an Introduction to Physical Geology Class

NASA Astrophysics Data System (ADS)

Brevik, Eric C.

2017-04-01

As instructors we are constantly looking for ways to improve student performance in the classroom. In an attempt to improve student performance in my GEOL 105 - Introduction to Physical Geology class, I added online homework assignments from the Pearson Mastering Geology program beginning in the Fall semester of 2014. There were several anticipated advantages to the online homework approach. If a student is struggling with a question they can get hints that don't tell them the answer, but are designed to stimulate their thinking and lead them towards the correct answer. The students also know immediately after submitting their answers which questions they got right and which were wrong, and they can go back to the wrong answers and try to determine the correct answer so they know what it is. This gives them much more rapid feedback than traditional paper homework, all of which makes this a more student-centered approach to learning. It is also my hope that the students find the online homework more interesting and interactive than paper-based homework, which I hope in turn will stimulate the students to be more likely to do the homework and take it seriously while also having some fun while doing it. As of the end of Fall semester 2016, I had been using the online homework assignments in my classes for three years. Therefore, I analyzed student performance in the three years prior to adopting the online homework and compared it to performance over the three years since adopting online homework. In the three years prior to adopting the online homework, the average grade in my classes was 73.8%; afterwards the average grade was 81.3%, for an improvement of 7.5% on average. Most of that improvement was in average test scores, which increased by 6.3% (67.4% prior to 73.6% after). The online homework did not improve the performance of the top students, but it did improve the performance of the other students. Prior to adopting the online homework, grade distribution in the class was 15% A (90-100% scores), 32% B (80-90%), 19% C (70-80%), 19% D (60-79%), and 15% F (<60%). After adopting the online homework, the grade distribution was 13% A, 48% B, 24% C, 13% D, and 2% F. Therefore, students who either passed the class but didn't excel or who struggled with the class prior to online homework adoption saw improvements in their performance, while students who showed truly outstanding performance remained constant. Test grades showed a similar trend. The average test scores for those who received an A in the class were 88.0% prior to and 88.6% after adopting the online homework, while test averages for students who received less than an A were 63.9% prior to and 71.4% (7.5% improvement) after adopting the online homework. I am always making small changes to my classes in an effort to improve them, but the only major change made to the class over the time period covered in this study was replacing paper homework assignments (which were not graded) with the online homework assignments. In addition, there was no statistical difference in scores in the Introduction to Physical Geology Laboratory over the same period (87.8% average before adoption, 85.7% after adoption). Students are required to take the lecture and laboratory at the same time, so the student populations were identical. The online homework applied to the lecture, where grades improved, but not to the laboratory, where grades remained consistent. Therefore, it was concluded that the addition of online homework to the Introduction to Physical Geology class had a strong positive effect on student scores. While students who would excel regardless of the format (those who received A grades) showed the same performance under both class formats, those who fell farther down the grade scale showed significant improvement with the use of the online homework assignments. Acknowledgement The integration of online homework assignments into the Introduction to Physical Geology class was funded by a Summer Faculty Fellowship from the North Dakota Space Grant Consortium.

Prevention of postsurgical scars: comparsion of efficacy and convenience between silicone gel sheet and topical silicone gel.

PubMed

Kim, Sue-Min; Choi, Jung-Sik; Lee, Jung-Ho; Kim, Young-Jin; Jun, Young-Joon

2014-11-01

To date, few studies have compared the effectiveness of topical silicone gels versus that of silicone gel sheets in preventing scars. In this prospective study, we compared the efficacy and the convenience of use of the 2 products. We enrolled 30 patients who had undergone a surgical procedure 2 weeks to 3 months before joining the study. These participants were randomly assigned to 2 treatment arms: one for treatment with a silicone gel sheet, and the other for treatment with a topical silicone gel. Vancouver Scar Scale (VSS) scores were obtained for all patients; in addition, participants completed scoring patient questionnaires 1 and 3 months after treatment onset. Our results reveal not only that no significant difference in efficacy exists between the 2 products but also that topical silicone gels are more convenient to use. While previous studies have advocated for silicone gel sheets as first-line therapies in postoperative scar management, we maintain that similar effects can be expected with topical silicone gel. The authors recommend that, when clinicians have a choice of silicone-based products for scar prevention, they should focus on each patient's scar location, lifestyle, and willingness to undergo scar prevention treatment.

Assessing fundamental 2-dimensional understanding of basic soft tissue techniques.

PubMed

Jabbour, Noel; Dobratz, Eric J; Dresner, Harley S; Hilger, Peter A

2011-01-01

To develop a written practical examination and scoring system for assessing trainee skills in basic soft-tissue techniques. A brief written practical examination was developed to assess the ability of trainees to sketch preoperative plans and postoperative results for common soft-tissue techniques: simple-excision, M-plasty, geometric broken line closure, Z-plasty, V-to-Y flap, and rhombic flap. A scoring system was developed to assign 0 to 5 points to each of 10 items on the examination for a total score of 0-50. The 15-minute examination was administered as a pretest, posttest, and 3-month posttest assessment as part of a soft-tissue course at our institution. University of Minnesota, Otolaryngology Department. Three raters reviewed all examination answer sheets independently. The pretest scores of examinees correlated strongly with their level of training; the average pretest for junior residents (PGY 1-2) compared with senior residents (PGY 4-5) was 17.3 (of 50) versus 26.0 (p < 0.01). The scoring system showed a high intrarater reliability and high interrater reliability with correlation coefficients of r = 0.99 and r = 0.95, respectively and agreement coefficients of κ = 0.82 and κ = 0.77, respectively. This written practical examination and scoring system may be used to assess the skills of trainees accurately in basic soft tissue techniques and to expose areas of deficiency that can be addressed in future training sessions. Copyright © 2011 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Heinrich events simulated across the glacial

NASA Astrophysics Data System (ADS)

Ziemen, F. A.; Mikolajewicz, U.

2015-12-01

Heinrich events are among the most prominent climate change events recorded in proxies across the northern hemisphere. They are the archetype of ice sheet — climate interactions on millennial time scales. Nevertheless, the exact mechanisms that cause Heinrich events are still under discussion, and their climatic consequences are far from being fully understood. We contribute to answering the open questions by studying Heinrich events in a coupled ice sheet model (ISM) atmosphere-ocean-vegetation general circulation model (AOVGCM) framework, where this variability occurs as part of the model generated internal variability. The setup consists of a northern hemisphere setup of the modified Parallel Ice Sheet Model (mPISM) coupled to the global AOVGCM ECHAM5/MPIOM/LPJ. The simulations were performed fully coupled and with transient orbital and greenhouse gas forcing. They span from several millennia before the last glacial maximum into the deglaciation. We analyze simulations where the ISM is coupled asynchronously to the AOVGCM and simulations where the ISM and the ocean model are coupled synchronously and the atmosphere model is coupled asynchronously to them. The modeled Heinrich events show a marked influence of the ice discharge on the Atlantic circulation and heat transport.

A Machine Learning-based Method for Question Type Classification in Biomedical Question Answering.

PubMed

Sarrouti, Mourad; Ouatik El Alaoui, Said

2017-05-18

Biomedical question type classification is one of the important components of an automatic biomedical question answering system. The performance of the latter depends directly on the performance of its biomedical question type classification system, which consists of assigning a category to each question in order to determine the appropriate answer extraction algorithm. This study aims to automatically classify biomedical questions into one of the four categories: (1) yes/no, (2) factoid, (3) list, and (4) summary. In this paper, we propose a biomedical question type classification method based on machine learning approaches to automatically assign a category to a biomedical question. First, we extract features from biomedical questions using the proposed handcrafted lexico-syntactic patterns. Then, we feed these features for machine-learning algorithms. Finally, the class label is predicted using the trained classifiers. Experimental evaluations performed on large standard annotated datasets of biomedical questions, provided by the BioASQ challenge, demonstrated that our method exhibits significant improved performance when compared to four baseline systems. The proposed method achieves a roughly 10-point increase over the best baseline in terms of accuracy. Moreover, the obtained results show that using handcrafted lexico-syntactic patterns as features' provider of support vector machine (SVM) lead to the highest accuracy of 89.40 %. The proposed method can automatically classify BioASQ questions into one of the four categories: yes/no, factoid, list, and summary. Furthermore, the results demonstrated that our method produced the best classification performance compared to four baseline systems.

Evaluation of RPE-Select: A Web-Based Respiratory Protective Equipment Selector Tool.

PubMed

Vaughan, Nick; Rajan-Sithamparanadarajah, Bob; Atkinson, Robert

2016-08-01

This article describes the evaluation of an open-access web-based respiratory protective equipment selector tool (RPE-Select, accessible at http://www.healthyworkinglives.com/rpe-selector). This tool is based on the principles of the COSHH-Essentials (C-E) control banding (CB) tool, which was developed for the exposure risk management of hazardous chemicals in the workplace by small and medium sized enterprises (SMEs) and general practice H&S professionals. RPE-Select can be used for identifying adequate and suitable RPE for dusts, fibres, mist (solvent, water, and oil based), sprays, volatile solids, fumes, gases, vapours, and actual or potential oxygen deficiency. It can be applied for substances and products with safety data sheets as well as for a large number of commonly encountered process-generated substances (PGS), such as poultry house dusts or welding fume. Potential international usability has been built-in by using the Hazard Statements developed for the Globally Harmonised System (GHS) and providing recommended RPE in picture form as well as with a written specification. Illustration helps to compensate for the variabilities in assigned protection factors across the world. RPE-Select uses easily understandable descriptions/explanations and an interactive stepwise flow for providing input/answers at each step. The output of the selection process is a report summarising the user input data and a selection of RPE, including types of filters where applicable, from which the user can select the appropriate one for each wearer. In addition, each report includes 'Dos' and 'Don'ts' for the recommended RPE. RPE-Select outcomes, based on up to 20 hypothetical use scenarios, were evaluated in comparison with other available RPE selection processes and tools, and by 32 independent users with a broad range of familiarities with industrial use scenarios in general and respiratory protection in particular. For scenarios involving substances having safety data sheets, 87% of RPE-Select outcomes resulted in a 'safe' RPE selection, while 98% 'safe' outcomes were achieved for scenarios involving process-generated substances. Reasons for the outliers were examined. User comments and opinions on the mechanics and usability of RPE-Select are also presented. © Crown copyright 2016.

Evaluation of RPE-Select: A Web-Based Respiratory Protective Equipment Selector Tool

PubMed Central

Vaughan, Nick; Rajan-Sithamparanadarajah, Bob; Atkinson, Robert

2016-01-01

This article describes the evaluation of an open-access web-based respiratory protective equipment selector tool (RPE-Select, accessible at http://www.healthyworkinglives.com/rpe-selector). This tool is based on the principles of the COSHH-Essentials (C-E) control banding (CB) tool, which was developed for the exposure risk management of hazardous chemicals in the workplace by small and medium sized enterprises (SMEs) and general practice H&S professionals. RPE-Select can be used for identifying adequate and suitable RPE for dusts, fibres, mist (solvent, water, and oil based), sprays, volatile solids, fumes, gases, vapours, and actual or potential oxygen deficiency. It can be applied for substances and products with safety data sheets as well as for a large number of commonly encountered process-generated substances (PGS), such as poultry house dusts or welding fume. Potential international usability has been built-in by using the Hazard Statements developed for the Globally Harmonised System (GHS) and providing recommended RPE in picture form as well as with a written specification. Illustration helps to compensate for the variabilities in assigned protection factors across the world. RPE-Select uses easily understandable descriptions/explanations and an interactive stepwise flow for providing input/answers at each step. The output of the selection process is a report summarising the user input data and a selection of RPE, including types of filters where applicable, from which the user can select the appropriate one for each wearer. In addition, each report includes ‘Dos’ and ‘Don’ts’ for the recommended RPE. RPE-Select outcomes, based on up to 20 hypothetical use scenarios, were evaluated in comparison with other available RPE selection processes and tools, and by 32 independent users with a broad range of familiarities with industrial use scenarios in general and respiratory protection in particular. For scenarios involving substances having safety data sheets, 87% of RPE-Select outcomes resulted in a ‘safe’ RPE selection, while 98% ‘safe’ outcomes were achieved for scenarios involving process-generated substances. Reasons for the outliers were examined. User comments and opinions on the mechanics and usability of RPE-Select are also presented. PMID:27286763

Preparing to Succeed in Marketing. [Curriculum Guide and] Answer Book/Teacher's Guide.

ERIC Educational Resources Information Center

Gavin, Marybeth; Foster, Gary

This guide outlines a curriculum that was designed to help students develop competencies identified by the Secretary's Commission on Achieving Necessary Skills (SCANS) as being necessary to succeed in marketing. Included in the guide are 19 assignments organized into 7 sections as follows: good health and good looks (staying healthy; staying clean…

An Examination of Text Complexity as Characterized by Readability and Cohesion

ERIC Educational Resources Information Center

Reed, Deborah K.; Kershaw-Herrera, Sarah

2016-01-01

To better understand dimensions of text complexity and their effect on the comprehension of adolescents, 103 high school seniors were randomly assigned to 4 groups. Each group read versions of the same 2 informational passages and answered comprehension test items targeting factual recall and inferences of causal content. Group A passages had a…

Co-Creation of Value in Higher Education: Using Social Network Marketing in the Recruitment of Students

ERIC Educational Resources Information Center

Fagerstrom, Asle; Ghinea, Gheorghita

2013-01-01

A social network recruitment campaign was prepared where applicants for information technology bachelor studies at a Norwegian university college were invited to join a Facebook group related to the subject of interest. Each Facebook group was assigned a contact person who received training to facilitate activities and in answering questions from…

Reactions. [Individualized Learning System (ILS) Chemistry Pac No. 5.

ERIC Educational Resources Information Center

Torop, William

This booklet is one of a set of eight designed to be used in a self-paced introductory chemistry course in conjunction with specified textbooks and computer-assisted instruction (CAI) modules. Each topic is introduced with a textbook reading assignment and additional readings are provided in the booklet. Also included are self-tests (and answers),…

The Relationship of Teacher-Personality Type to Grading Freshman Composition Essays: An Empirical Study.

ERIC Educational Resources Information Center

Covner, Thelma Crockin

To gain insight into the evaluation of college freshman compositions, a study explored the relationship between the personality type of the instructor and the grades assigned to essays written by freshman composition students. The sample comprised 23 college instructors who answered a short questionnaire, graded the same expository essay, and…

Technology Is the Answer, But What Was the Question? Audiotape vs. Videotape for Individualized Instruction.

ERIC Educational Resources Information Center

Tabachnick, Barbara Gerson; And Others

1978-01-01

In an evaluation of supplementary learning aids students were assigned to one of four learning conditions: (1) videotape plus worksheet, (2) audiotape plus worksheet, (3) combination of audio- and videotape plus worksheet, and (4) worksheet only. Results reported include test scores and ratings of helpfulness, as well as student preferences and…

An Analysis of the Candidate Teachers' Beliefs Related to Knowledge, Learning and Teaching

ERIC Educational Resources Information Center

Bay, Erdal; Vural, Ömer Faruk; Demir, Servet; Bagceci, Birsen

2015-01-01

Candidate teachers have several beliefs related to their knowledge, learning and teaching. The purpose of this study is to analyze the beliefs of candidate teachers about knowledge, learning and teaching. Candidate teachers were assigned a scale and from the answers "belief points" were obtained based on their attitudes about these three…

No Randomization? No Problem: Experimental Control and Random Assignment in Single Case Research

ERIC Educational Resources Information Center

Ledford, Jennifer R.

2018-01-01

Randomization of large number of participants to different treatment groups is often not a feasible or preferable way to answer questions of immediate interest to professional practice. Single case designs (SCDs) are a class of research designs that are experimental in nature but require only a few participants, all of whom receive the…

Carbon. [Individualized Learning System (ILS) Chemistry Pac No. 7.

ERIC Educational Resources Information Center

Torop, William

This booklet is one of a set of eight designed to be used in a self-paced introductory chemistry course in conjunction with specified textbooks and computer-assisted instruction (CAI) modules. Each topic is introduced with a textbook reading assignment and additional readings are provided in the booklet. Also included are self-tests (and answers),…

Statistical Refinement of the Q-Matrix in Cognitive Diagnosis

ERIC Educational Resources Information Center

Chiu, Chia-Yi

2013-01-01

Most methods for fitting cognitive diagnosis models to educational test data and assigning examinees to proficiency classes require the Q-matrix that associates each item in a test with the cognitive skills (attributes) needed to answer it correctly. In most cases, the Q-matrix is not known but is constructed from the (fallible) judgments of…

Further exploration of the conformational space of α-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.

PubMed

Verasdonck, Joeri; Bousset, Luc; Gath, Julia; Melki, Ronald; Böckmann, Anja; Meier, Beat H

2016-04-01

Polymorphism is a common and important phenomenon for protein fibrils which has been linked to the appearance of strains in prion and other neurodegenerative diseases. Parkinson disease is a frequently occurring neurodegenerative pathology, tightly associated with the formation of Lewy bodies. These deposits mainly consist of α-synuclein in fibrillar, β-sheet-rich form. α-synuclein is known to form numerous different polymorphs, which show distinct structural features. Here, we describe the chemical shift assignments, and derive the secondary structure, of a polymorph that was fibrillized at higher-than-physiological pH conditions. The fibrillar core contains residues 40-95, with both the C- and N-terminus not showing any ordered, rigid parts. The chemical shifts are similar to those recorded previously for an assigned polymorph that was fibrillized at neutral pH.

Withholding answers during hands-on scientific investigations? Comparing effects on developing students' scientific knowledge, reasoning, and application

NASA Astrophysics Data System (ADS)

Zhang, Lin

2018-03-01

As more concerns have been raised about withholding answers during science teaching, this article argues for a need to detach 'withholding answers' from 'hands-on' investigation tasks. The present study examined students' learning of light-related content through three conditions: 'hands-on' + no 'withholding' (hands-on only: HO), 'hands-on' + 'withholding' (hands-on investigation with answers withheld: HOW), and no 'hands-on' + no 'withholding' (direction instruction: DI). Students were assessed in terms of how well they (1) knew the content taught in class; (2) reasoned with the learned content; and (3) applied the learned content to real-life situations. Nine classes of students at 4th and 5th grades, N = 136 in total, were randomly assigned to one of the three conditions. ANCOVA results showed that students in the hands-on only condition reasoned significantly better than those in the other two conditions. Students in this condition also seemed to know the content fairly better although the advance was not significant. Students in all three conditions did not show a statistically significant difference in their ability to apply the learned content to real-life situations. The findings from this study provide important contributions regarding issues relating to withholding answers during guided scientific inquiry.

Using the Weighted Keyword Model to Improve Information Retrieval for Answering Biomedical Questions

PubMed Central

Yu, Hong; Cao, Yong-gang

2009-01-01

Physicians ask many complex questions during the patient encounter. Information retrieval systems that can provide immediate and relevant answers to these questions can be invaluable aids to the practice of evidence-based medicine. In this study, we first automatically identify topic keywords from ad hoc clinical questions with a Condition Random Field model that is trained over thousands of manually annotated clinical questions. We then report on a linear model that assigns query weights based on their automatically identified semantic roles: topic keywords, domain specific terms, and their synonyms. Our evaluation shows that this weighted keyword model improves information retrieval from the Text Retrieval Conference Genomics track data. PMID:21347188

Using the weighted keyword model to improve information retrieval for answering biomedical questions.

PubMed

Yu, Hong; Cao, Yong-Gang

2009-03-01

Physicians ask many complex questions during the patient encounter. Information retrieval systems that can provide immediate and relevant answers to these questions can be invaluable aids to the practice of evidence-based medicine. In this study, we first automatically identify topic keywords from ad hoc clinical questions with a Condition Random Field model that is trained over thousands of manually annotated clinical questions. We then report on a linear model that assigns query weights based on their automatically identified semantic roles: topic keywords, domain specific terms, and their synonyms. Our evaluation shows that this weighted keyword model improves information retrieval from the Text Retrieval Conference Genomics track data.

RELIGION AND DISASTER VICTIM IDENTIFICATION.

PubMed

Levinson, Jay; Domb, Abraham J

2014-12-01

Disaster Victim Identification (DVI) is a triangle, the components of which are secular law, religious law and custom and professional methods. In cases of single non-criminal deaths, identification often rests with a hospital or a medical authority. When dealing with criminal or mass death incidents, the law, in many jurisdictions, assigns identification to the coroner/medical examiner, who typically uses professional methods and only answers the religious requirements of the deceased's next-of-kin according to his personal judgment. This article discusses religious considerations regarding scientific methods and their limitations, as well as the ethical issues involved in the government coroner/medical examiner's becoming involved in clarifying and answering the next-of-kin's religious requirements.

Precision and Disclosure in Text and Voice Interviews on Smartphones

PubMed Central

Antoun, Christopher; Ehlen, Patrick; Fail, Stefanie; Hupp, Andrew L.; Johnston, Michael; Vickers, Lucas; Yan, H. Yanna; Zhang, Chan

2015-01-01

As people increasingly communicate via asynchronous non-spoken modes on mobile devices, particularly text messaging (e.g., SMS), longstanding assumptions and practices of social measurement via telephone survey interviewing are being challenged. In the study reported here, 634 people who had agreed to participate in an interview on their iPhone were randomly assigned to answer 32 questions from US social surveys via text messaging or speech, administered either by a human interviewer or by an automated interviewing system. 10 interviewers from the University of Michigan Survey Research Center administered voice and text interviews; automated systems launched parallel text and voice interviews at the same time as the human interviews were launched. The key question was how the interview mode affected the quality of the response data, in particular the precision of numerical answers (how many were not rounded), variation in answers to multiple questions with the same response scale (differentiation), and disclosure of socially undesirable information. Texting led to higher quality data—fewer rounded numerical answers, more differentiated answers to a battery of questions, and more disclosure of sensitive information—than voice interviews, both with human and automated interviewers. Text respondents also reported a strong preference for future interviews by text. The findings suggest that people interviewed on mobile devices at a time and place that is convenient for them, even when they are multitasking, can give more trustworthy and accurate answers than those in more traditional spoken interviews. The findings also suggest that answers from text interviews, when aggregated across a sample, can tell a different story about a population than answers from voice interviews, potentially altering the policy implications from a survey. PMID:26060991

To Compare PubMed Clinical Queries and UpToDate in Teaching Information Mastery to Clinical Residents: A Crossover Randomized Controlled Trial

PubMed Central

Sayyah Ensan, Ladan; Faghankhani, Masoomeh; Javanbakht, Anna; Ahmadi, Seyed-Foad; Baradaran, Hamid Reza

2011-01-01

Purpose To compare PubMed Clinical Queries and UpToDate regarding the amount and speed of information retrieval and users' satisfaction. Method A cross-over randomized trial was conducted in February 2009 in Tehran University of Medical Sciences that included 44 year-one or two residents who participated in an information mastery workshop. A one-hour lecture on the principles of information mastery was organized followed by self learning slide shows before using each database. Subsequently, participants were randomly assigned to answer 2 clinical scenarios using either UpToDate or PubMed Clinical Queries then crossed to use the other database to answer 2 different clinical scenarios. The proportion of relevantly answered clinical scenarios, time to answer retrieval, and users' satisfaction were measured in each database. Results Based on intention-to-treat analysis, participants retrieved the answer of 67 (76%) questions using UpToDate and 38 (43%) questions using PubMed Clinical Queries (P<0.001). The median time to answer retrieval was 17 min (95% CI: 16 to 18) using UpToDate compared to 29 min (95% CI: 26 to 32) using PubMed Clinical Queries (P<0.001). The satisfaction with the accuracy of retrieved answers, interaction with UpToDate and also overall satisfaction were higher among UpToDate users compared to PubMed Clinical Queries users (P<0.001). Conclusions For first time users, using UpToDate compared to Pubmed Clinical Querries can lead to not only a higher proportion of relevant answer retrieval within a shorter time, but also a higher users' satisfaction. So, addition of tutoring pre-appraised sources such as UpToDate to the information mastery curricula seems to be highly efficient. PMID:21858142

To compare PubMed Clinical Queries and UpToDate in teaching information mastery to clinical residents: a crossover randomized controlled trial.

PubMed

Sayyah Ensan, Ladan; Faghankhani, Masoomeh; Javanbakht, Anna; Ahmadi, Seyed-Foad; Baradaran, Hamid Reza

2011-01-01

To compare PubMed Clinical Queries and UpToDate regarding the amount and speed of information retrieval and users' satisfaction. A cross-over randomized trial was conducted in February 2009 in Tehran University of Medical Sciences that included 44 year-one or two residents who participated in an information mastery workshop. A one-hour lecture on the principles of information mastery was organized followed by self learning slide shows before using each database. Subsequently, participants were randomly assigned to answer 2 clinical scenarios using either UpToDate or PubMed Clinical Queries then crossed to use the other database to answer 2 different clinical scenarios. The proportion of relevantly answered clinical scenarios, time to answer retrieval, and users' satisfaction were measured in each database. Based on intention-to-treat analysis, participants retrieved the answer of 67 (76%) questions using UpToDate and 38 (43%) questions using PubMed Clinical Queries (P<0.001). The median time to answer retrieval was 17 min (95% CI: 16 to 18) using UpToDate compared to 29 min (95% CI: 26 to 32) using PubMed Clinical Queries (P<0.001). The satisfaction with the accuracy of retrieved answers, interaction with UpToDate and also overall satisfaction were higher among UpToDate users compared to PubMed Clinical Queries users (P<0.001). For first time users, using UpToDate compared to Pubmed Clinical Queries can lead to not only a higher proportion of relevant answer retrieval within a shorter time, but also a higher users' satisfaction. So, addition of tutoring pre-appraised sources such as UpToDate to the information mastery curricula seems to be highly efficient.

Precision and Disclosure in Text and Voice Interviews on Smartphones.

PubMed

Schober, Michael F; Conrad, Frederick G; Antoun, Christopher; Ehlen, Patrick; Fail, Stefanie; Hupp, Andrew L; Johnston, Michael; Vickers, Lucas; Yan, H Yanna; Zhang, Chan

2015-01-01

As people increasingly communicate via asynchronous non-spoken modes on mobile devices, particularly text messaging (e.g., SMS), longstanding assumptions and practices of social measurement via telephone survey interviewing are being challenged. In the study reported here, 634 people who had agreed to participate in an interview on their iPhone were randomly assigned to answer 32 questions from US social surveys via text messaging or speech, administered either by a human interviewer or by an automated interviewing system. 10 interviewers from the University of Michigan Survey Research Center administered voice and text interviews; automated systems launched parallel text and voice interviews at the same time as the human interviews were launched. The key question was how the interview mode affected the quality of the response data, in particular the precision of numerical answers (how many were not rounded), variation in answers to multiple questions with the same response scale (differentiation), and disclosure of socially undesirable information. Texting led to higher quality data-fewer rounded numerical answers, more differentiated answers to a battery of questions, and more disclosure of sensitive information-than voice interviews, both with human and automated interviewers. Text respondents also reported a strong preference for future interviews by text. The findings suggest that people interviewed on mobile devices at a time and place that is convenient for them, even when they are multitasking, can give more trustworthy and accurate answers than those in more traditional spoken interviews. The findings also suggest that answers from text interviews, when aggregated across a sample, can tell a different story about a population than answers from voice interviews, potentially altering the policy implications from a survey.

A new criterion needed to evaluate reliability of digital protective relays

NASA Astrophysics Data System (ADS)

Gurevich, Vladimir

2012-11-01

There is a wide range of criteria and features for evaluating reliability in engineering; but as many as there are, only one of them has been chosen to evaluate reliability of Digital Protective Relays (DPR) in the technical documentation: Mean (operating) Time Between Failures (MTBF), which has gained universal currency and has been specified in technical manuals, information sheets, tender documentation as the key indicator of DPR reliability. But is the choice of this criterion indeed wise? The answer to this question is being sought by the author of this article.

An efficient randomized algorithm for contact-based NMR backbone resonance assignment.

PubMed

Kamisetty, Hetunandan; Bailey-Kellogg, Chris; Pandurangan, Gopal

2006-01-15

Backbone resonance assignment is a critical bottleneck in studies of protein structure, dynamics and interactions by nuclear magnetic resonance (NMR) spectroscopy. A minimalist approach to assignment, which we call 'contact-based', seeks to dramatically reduce experimental time and expense by replacing the standard suite of through-bond experiments with the through-space (nuclear Overhauser enhancement spectroscopy, NOESY) experiment. In the contact-based approach, spectral data are represented in a graph with vertices for putative residues (of unknown relation to the primary sequence) and edges for hypothesized NOESY interactions, such that observed spectral peaks could be explained if the residues were 'close enough'. Due to experimental ambiguity, several incorrect edges can be hypothesized for each spectral peak. An assignment is derived by identifying consistent patterns of edges (e.g. for alpha-helices and beta-sheets) within a graph and by mapping the vertices to the primary sequence. The key algorithmic challenge is to be able to uncover these patterns even when they are obscured by significant noise. This paper develops, analyzes and applies a novel algorithm for the identification of polytopes representing consistent patterns of edges in a corrupted NOESY graph. Our randomized algorithm aggregates simplices into polytopes and fixes inconsistencies with simple local modifications, called rotations, that maintain most of the structure already uncovered. In characterizing the effects of experimental noise, we employ an NMR-specific random graph model in proving that our algorithm gives optimal performance in expected polynomial time, even when the input graph is significantly corrupted. We confirm this analysis in simulation studies with graphs corrupted by up to 500% noise. Finally, we demonstrate the practical application of the algorithm on several experimental beta-sheet datasets. Our approach is able to eliminate a large majority of noise edges and to uncover large consistent sets of interactions. Our algorithm has been implemented in the platform-independent Python code. The software can be freely obtained for academic use by request from the authors.

Natural and man-made hexavalent chromium, Cr(VI), in groundwater near a mapped plume, Hinkley, California—study progress as of May 2017, and a summative-scale approach to estimate background Cr(VI) concentrations

USGS Publications Warehouse

Izbicki, John A.; Groover, Krishangi D.

2018-03-22

This report describes (1) work done between January 2015 and May 2017 as part of the U.S. Geological Survey (USGS) hexavalent chromium, Cr(VI), background study and (2) the summative-scale approach to be used to estimate the extent of anthropogenic (man-made) Cr(VI) and background Cr(VI) concentrations near the Pacific Gas and Electric Company (PG&E) natural gas compressor station in Hinkley, California. Most of the field work for the study was completed by May 2017. The summative-scale approach and calculation of Cr(VI) background were not well-defined at the time the USGS proposal for the background Cr(VI) study was prepared but have since been refined as a result of data collected as part of this study. The proposed summative scale consists of multiple items, formulated as questions to be answered at each sampled well. Questions that compose the summative scale were developed to address geologic, hydrologic, and geochemical constraints on Cr(VI) within the study area. Each question requires a binary (yes or no) answer. A score of 1 will be assigned for an answer that represents data consistent with anthropogenic Cr(VI); a score of –1 will be assigned for an answer that represents data inconsistent with anthropogenic Cr(VI). The areal extent of anthropogenic Cr(VI) estimated from the summative-scale analyses will be compared with the areal extent of anthropogenic Cr(VI) estimated on the basis of numerical groundwater flow model results, along with particle-tracking analyses. On the basis of these combined results, background Cr(VI) values will be estimated for “Mojave-type” deposits, and other deposits, in different parts of the study area outside the summative-scale mapped extent of anthropogenic Cr(VI).

The effect of postal questionnaire burden on response rate and answer patterns following admission to intensive care: a randomised controlled trial.

PubMed

Hatch, Robert; Young, Duncan; Barber, Vicki; Harrison, David A; Watkinson, Peter

2017-03-27

The effects of postal questionnaire burden on return rates and answers given are unclear following treatment on an intensive care unit (ICU). We aimed to establish the effects of different postal questionnaire burdens on return rates and answers given. Design: A parallel group randomised controlled trial. We assigned patients by computer-based randomisation to one of two questionnaire packs (Group A and Group B). Patients from 26 ICUs in the United Kingdom. Patients who had received at least 24 h of level 3 care and were 16 years of age or older. Patients did not know that there were different questionnaire burdens. The study included 18,490 patients. 12,170 were eligible to be sent a questionnaire pack at 3 months. We sent 12,105 questionnaires (6112 to group A and 5993 to group B). The Group A pack contained demographic and EuroQol group 5 Dimensions 3 level (EQ-5D-3 L) questionnaires, making four questionnaire pages. The Group B pack also contained the Hospital Anxiety and Depression Score (HADS) and the Post-Traumatic Stress Disorder Check List-Civilian (PCL-C) questionnaires, making eight questionnaire pages in total. Questionnaire return rate 3 months after ICU discharge by group. In group A, 2466/6112 (40.3%) participants responded at 3 months. In group B 2315/ 5993 (38.6%) participants responded (difference 1.7% CI for difference 0-3.5% p = 0.053). Group A reported better functionality than group B in the EQ-5D-3 L mobility (41% versus 37% reporting no problems p = 0.003) and anxiety/depression (59% versus 55% reporting no problems p = 0.017) domains. In survivors of intensive care, questionnaire burden had no effect on return rates. However, questionnaire burden affected answers to the same questionnaire (EQ-5D-3 L). ISRCTN69112866 (assigned 02/05/2006).

NMR analysis of cross strand aromatic interactions in an 8 residue hairpin and a 14 residue three stranded β-sheet peptide.

PubMed

Sonti, Rajesh; Rai, Rajkishor; Ragothama, Srinivasarao; Balaram, Padmanabhan

2012-12-13

Cross strand aromatic interactions between a facing pair of phenylalanine residues in antiparallel β-sheet structures have been probed using two structurally defined model peptides. The octapeptide Boc-LFV(D)P(L)PLFV-OMe (peptide 1) favors the β-hairpin conformation nucleated by the type II' β-turn formed by the (D)Pro-(L)Pro segment, placing Phe2 and Phe7 side chains in proximity. Two centrally positioned (D)Pro-(L)Pro segments facilitate the three stranded β-sheet formation in the 14 residue peptide Boc-LFV(D)P(L)PLFVA(D)P(L)PLFV-OMe (peptide 2) in which the Phe2/Phe7 orientations are similar to that in the octapeptide. The anticipated folded conformations of peptides 1 and 2 are established by the delineation of intramolecularly hydrogen bonded NH groups and by the observation of specific cross strand NOEs. The observation of ring current shifted aromatic protons is a diagnostic of close approach of the Phe2 and Phe7 side chains. Specific assignment of aromatic proton resonances using HSQC and HSQC-TOCSY methods allow an analysis of interproton NOEs between the spatially proximate aromatic rings. This approach facilitates specific assignments in systems containing multiple aromatic rings in spectra at natural abundance. Evidence is presented for a dynamic process which invokes a correlated conformational change about the C(α)-C(β)(χ(1)) bond for the pair of interacting Phe residues. NMR results suggest that aromatic ring orientations observed in crystals are maintained in solution. Anomalous temperature dependence of ring current induced proton chemical shifts suggests that solvophobic effects may facilitate aromatic ring clustering in apolar solvents.

Enhanced osseointegration of titanium implants in a rat model of osteoporosis using multilayer bone mesenchymal stem cell sheets

PubMed Central

Duan, Yan; Ma, Wei; Li, Dehua; Wang, Tongfei; Liu, Baolin

2017-01-01

The present study aimed to investigate whether bone marrow-derived mesenchymal stem cell (BMSC) sheets combined with titanium implants enhanced implant osseointegration in an ovariectomized (OVX) rat model of osteoporosis. Sprague-Dawley rats were randomly assigned into a test group and control group. Allogenic BMSCs were collected from the rats, cultured and stored via cryopreservation. At 6 months post-ovariectomy, establishment of the OVX model was confirmed by micro-computed tomography (CT) measurements. BMSC sheets were subsequently layered and wrapped over titanium implants for implantation. Unmodified implants served as the control. At 8 weeks post-implantation, samples were observed by micro-CT reconstruction and histomorphometric evaluation. Micro-CT reconstruction identified a marked improvement in the surrounding bone volume following treatment, with data analyses indicating a significant increase in bone volume in the BMSC-implant group compared with the control implant group (P<0.05). In addition, histological staining identified new bone formation and an increased rate of bone-implant contact surrounding the BMSC-implant constructs. These results indicate that the use of BMSC sheets as a novel tissue engineering approach improves the osseointegration of titanium implants in an osteoporosis model. This method may expand the operative indications in patients with osteoporosis and improve the success rate of clinical dental implant treatments. PMID:29250137

The cosmic web and the orientation of angular momenta

NASA Astrophysics Data System (ADS)

Libeskind, Noam I.; Hoffman, Yehuda; Knebe, Alexander; Steinmetz, Matthias; Gottlöber, Stefan; Metuki, Ofer; Yepes, Gustavo

2012-03-01

We use a 64 h-1 Mpc dark-matter-only cosmological simulation to examine the large-scale orientation of haloes and substructures with respect to the cosmic web. A web classification scheme based on the velocity shear tensor is used to assign to each halo in the simulation a web type: knot, filament, sheet or void. Using ˜106 haloes that span ˜3 orders of magnitude in mass, the orientation of the halo's spin and the orbital angular momentum of subhaloes with respect to the eigenvectors of the shear tensor is examined. We find that the orbital angular momentum of subhaloes tends to align with the intermediate eigenvector of the velocity shear tensor for all haloes in knots, filaments and sheets. This result indicates that the kinematics of substructures located deep within the virialized regions of a halo is determined by its infall which in turn is determined by the large-scale velocity shear, a surprising result given the virialized nature of haloes. The non-random nature of subhalo accretion is thus imprinted on the angular momentum measured at z= 0. We also find that the haloes' spin axis is aligned with the third eigenvector of the velocity shear tensor in filaments and sheets: the halo spin axis points along filaments and lies in the plane of cosmic sheets.

Using Symmetric Predication of Endogenous Subgroups for Causal Inferences about Program Effects under Robust Assumptions: Part Two of a Method Note in Three Parts

ERIC Educational Resources Information Center

Bell, Stephen H.; Peck, Laura R.

2013-01-01

To answer "what works?" questions about policy interventions based on an experimental design, Peck (2003) proposes to use baseline characteristics to symmetrically divide treatment and control group members into subgroups defined by endogenously determined postrandom assignment events. Symmetric prediction of these subgroups in both…

A Special Assignment from NASA: Understanding Earth's Atmosphere through the Integration of Science and Mathematics

ERIC Educational Resources Information Center

Fox, Justine E.; Glen, Nicole J.

2012-01-01

Have your students ever wondered what NASA scientists do? Have they asked you what their science and mathematics lessons have to do with the real world? This unit about Earth's atmosphere can help to answer both of those questions. The unit described here showcases "content specific integration" of science and mathematics in that the lessons meet…

A Comparison of Multi-Age and Homogeneous Age Grouping in Early Childhood Centers.

ERIC Educational Resources Information Center

Freedman, Paula

Studies from several countries are described in this review of literature pertinent to assigning day care children to multi-age or homogeneous age groups. Three issues are discussed in this regard: (1) What difference does it make how one groups children? The answer is that a profound difference to children, staff, and parents may occur in terms…

Some Effects of School Building Renovation on Pupil Attitudes and Behavior in Selected Junior High Schools.

ERIC Educational Resources Information Center

Cramer, Robert Joseph

A study of 2,300 junior high school students from three schools determined the effect of a newly renovated school, a new school environment, and an old dilapidated school environment on their attitudes and behavior. Points were assigned to their answers; high scores indicated a positive attitude. Results show attitudes were lowest in the old…

How to Set up Oral Homework: A Case of Limited Technology

ERIC Educational Resources Information Center

Mendez, Elba

2010-01-01

Homework usually consists of the learners' written account of how they interpreted a task set by the teacher, and is generally defined as out-of-class assignments that are handed in for the instructor to grade. Learners may work individually or with partners to answer simple or challenging linguistic exercises, sketch out a mind map, or develop a…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fogh, R.H.; Mabbutt, B.C.; Kem, W.R.

Sequence-specific assignments are reported for the 500-MHz H nuclear magnetic resonance (NMR) spectrum of the 48-residue polypeptide neurotoxin I from the sea anemone Stichodactyla helianthus (Sh I). Spin systems were first identified by using two-dimensional relayed or multiple quantum filtered correlation spectroscopy, double quantum spectroscopy, and spin lock experiments. Specific resonance assignments were then obtained from nuclear Overhauser enhancement (NOE) connectivities between protons from residues adjacent in the amino acid sequence. Of a total of 265 potentially observable resonances, 248 (i.e., 94%) were assigned, arising from 39 completely and 9 partially assigned amino acid spin systems. The secondary structure ofmore » Sh I was defined on the basis of the pattern of sequential NOE connectivities. NOEs between protons on separate strands of the polypeptide backbone, and backbone amide exchange rates. Sh I contains a four-stranded antiparallel {beta}-sheet encompassing residues 1-5, 16-24, 30-33, and 40-46, with a {beta}-bulge at residues 17 and 18 and a reverse turn, probably a type II {beta}-turn, involving residues 27-30. No evidence of {alpha}-helical structure was found.« less

Improving the knowledge of labour and delivery nurses in India: a randomized controlled trial of mentoring and case sheets in primary care centres.

PubMed

Bradley, Janet; Jayanna, Krishnamurthy; Shaw, Souradet; Cunningham, Troy; Fischer, Elizabeth; Mony, Prem; Ramesh, B M; Moses, Stephen; Avery, Lisa; Crockett, Maryanne; Blanchard, James F

2017-01-07

Birthing in health facilities in India has increased over the last few years, yet maternal and neonatal mortality rates remain high. Clinical mentoring with case sheets or checklists for nurses is viewed as essential for on-going knowledge transfer, particularly where basic training is inadequate. This paper summarizes a study of the effect of such a programme on staff knowledge and skills in a randomized trial of 295 nurses working in 108 Primary Health Centres (PHCs) in Karnataka, India. Stratifying by district, half of the PHCs were randomly assigned to be intervention sites and provided with regular mentoring visits where case sheet/checklists were a central job and teaching aid, and half to be control sites, where no support was provided except provision of case sheets. Nurses' knowledge and skills around normal labour, labour complications and neonate issues were tested before the intervention began and again one year later. Univariate and multivariate analyses were conducted to examine the effect of mentoring and case sheets. Overall, on none of the 3 measures, did case sheet use without mentoring add anything to the basic nursing training when controlling for other factors. Only individuals who used both case-sheets and received mentoring scored significantly higher on the normal labour and neonate indices, scoring almost twice as high as those who only used case-sheets. This group was also associated with significantly higher scores on the complications of labour index, with their scores 2.3 times higher on average than the case sheet only control group. Individuals from facilities with 21 or more deliveries in a month tended to fare worse on all 3 indices. There were no differences in outcomes according to district or years of experience. This study demonstrates that provision of case sheets or checklists alone is insufficient to improve knowledge and practices. However, on-site mentoring in combination with case sheets can have a demonstrable effect on improving nurse knowledge and skills around essential obstetric and neonatal care in remote rural areas of India. We recommend scaling up of this mentoring model in order to improve staff knowledge and skills and reduce maternal and neonatal mortality in India. This study is registered at clinicaltrials.gov, Identifier No. NCT02004912 , November 27, 2013.

Case in Point: Stronach v. Virginia State U. (2008): Does Academic Freedom Give a Professor the Final Say on Grades?

ERIC Educational Resources Information Center

White, Lawrence

2008-01-01

Virginia State University Carey E. Stronach assigned an undergraduate a final grade of D after the student had failed three classroom quizzes. The student, who claimed to have received A's on two of the quizzes, submitted fax copies of his score sheets to Stronach, who concluded that the student had doctored his scores. The student appealed to the…

Development of probabilistic thinking-oriented learning tools for probability materials at junior high school students

NASA Astrophysics Data System (ADS)

Sari, Dwi Ivayana; Hermanto, Didik

2017-08-01

This research is a developmental research of probabilistic thinking-oriented learning tools for probability materials at ninth grade students. This study is aimed to produce a good probabilistic thinking-oriented learning tools. The subjects were IX-A students of MTs Model Bangkalan. The stages of this development research used 4-D development model which has been modified into define, design and develop. Teaching learning tools consist of lesson plan, students' worksheet, learning teaching media and students' achievement test. The research instrument used was a sheet of learning tools validation, a sheet of teachers' activities, a sheet of students' activities, students' response questionnaire and students' achievement test. The result of those instruments were analyzed descriptively to answer research objectives. The result was teaching learning tools in which oriented to probabilistic thinking of probability at ninth grade students which has been valid. Since teaching and learning tools have been revised based on validation, and after experiment in class produced that teachers' ability in managing class was effective, students' activities were good, students' responses to the learning tools were positive and the validity, sensitivity and reliability category toward achievement test. In summary, this teaching learning tools can be used by teacher to teach probability for develop students' probabilistic thinking.

¹⁵N, ¹³C and ¹H resonance assignments and secondary structure determination of a variable heavy domain of a heavy chain antibody.

PubMed

Prosser, Christine E; Waters, Lorna C; Muskett, Frederick W; Veverka, Vaclav; Addis, Philip W; Griffin, Laura M; Baker, Terry S; Lawson, Alastair D G; Wernery, Ulrich; Kinne, Jorg; Henry, Alistair J; Taylor, Richard J; Carr, Mark D

2014-04-01

Heavy chain antibodies differ in structure to conventional antibodies lacking both the light chain and the first heavy chain constant domain (CH1). Characteristics of the antigen-binding variable heavy domain of the heavy chain antibody (VHH) including the smaller size, high solubility and stability make them an attractive alternative to more traditional antibody fragments for detailed NMR-based structural analysis. Here we report essentially complete backbone and side chain (15)N, (13)C and (1)H assignments for a free VHH. Analysis of the backbone chemical shift data obtained indicates that the VHH is comprised predominantly of β-sheets corresponding to nearly 60% of the protein backbone.

[Response rate, missing values, validity and reproducibility of responses in mark-sheet and conventional questionnaires].

PubMed

Tsubono, Y; Fukao, A; Hisamichi, S

1994-06-01

A self-administered questionnaire using the mark-sheet method (MSM), in which responses of subjects are computer processed directly through an optical scanning device, has recently been utilized in epidemiologic surveys. Compared to the data coding process for a conventional questionnaire, in which a keypuncher enters the responses manually into a computer (manual method; MM), optical scanning requires less time and cost. Accuracy of the MSM for use in the general population in Japan, however, remains uncertain. Therefore the response rates, frequencies of missing values, validity and reproducibility of the answers in self-administered questionnaires were compared between the MSM and MM. Subjects were 463 residents aged 40-69 years living in 6 local districts of a rural town in northeastern Japan. They were randomly allocated, by district basis, to the MSM group (n = 242) or the MM group (n = 221). The questionnaire was delivered and collected at the subject's home by volunteers. Two weeks after collecting the original questionnaire, the same type of questionnaire was again distributed to half of the responders randomly chosen to investigate reproducibility. The overall response rate did not differ in MSM and MM (96.7% vs 98.2%, p = 0.312). Among questions with a multiple-choice type of answer, proportions of missing values were not different for most of the items, but it was lower in MSM for all of the 33 food frequency items. Reproducibilities of food frequency items measured by Spearman's rank correlation did not differ substantially in two groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Q2Stress: A database for multiple cues to stress assignment in Italian.

PubMed

Spinelli, Giacomo; Sulpizio, Simone; Burani, Cristina

2017-12-01

In languages where the position of lexical stress within a word is not predictable from print, readers rely on distributional information extracted from the lexicon in order to assign stress. Lexical databases are thus especially important for researchers willing to address stress assignment in those languages. Here we present Q2Stress, a new database aimed to fill the lack of such a resource for Italian. Q2Stress includes multiple cues readers may use in assigning stress, such as type and token frequency of stress patterns as well as their distribution with respect to number of syllables, grammatical category, word beginnings, word endings, and consonant-vowel structures. Furthermore, for the first time, data for both adults and children are available. Q2Stress may help researchers to answer empirical as well as theoretical questions about stress assignment and stress-related issues, and more in general, to explore the orthography-to-phonology relation in reading. Q2Stress is designed as a user-friendly resource, as it comes with scripts allowing researchers to explore and select their own stimuli according to several criteria as well as summary tables for overall data analysis.

Conformational and vibrational reassessment of solid paracetamol

NASA Astrophysics Data System (ADS)

Amado, Ana M.; Azevedo, Celeste; Ribeiro-Claro, Paulo J. A.

2017-08-01

This work provides an answer to the urge for a more detailed and accurate knowledge of the vibrational spectrum of the widely used analgesic/antipyretic drug commonly known as paracetamol. A comprehensive spectroscopic analysis - including infrared, Raman, and inelastic neutron scattering (INS) - is combined with a computational approach which takes account for the effects of intermolecular interactions in the solid state. This allows a full reassessment of the vibrational assignments for Paracetamol, thus preventing the propagation of incorrect data analysis and misassignments already found in the literature. In particular, the vibrational modes involving the hydrogen-bonded Nsbnd H and Osbnd H groups are correctly reallocated to bands shifted by up to 300 cm- 1 relatively to previous assignments.

Italo-Swiss "Chalk and blackboard interactive 2-day workshop"-participants feedback.

PubMed

Camozzi, Pietro; Faré, Pietro B; Lavagno, Camilla; Milani, Gregorio P; Fossali, Emilio F; Bianchetti, Mario G; Lava, Sebastiano A G

2015-08-20

Ten "chalk and blackboard interactive workshops" have taken place between 2011 and 2015 in Southern Switzerland or Italy. Students, residents and expert pediatricians meet during 2 days and discuss 10-15 cases. Pediatricians promote reasoning, provide supporting information and correct statements. Emphasis is placed on history taking and examination, and on all participants being involved in a stimulating atmosphere. Thirty-seven participants were asked, ≥3 months after workshop-completion, to evaluate the workshop and a recent teaching session. Thirty answered and scored the workshop as excellent (N = 24) or above average (N = 6). The scores assigned to the workshop were higher (P < 0.001) than those assigned to the lecture-based teaching.

Hazard banding in compliance with the new Globally Harmonised System (GHS) for use in control banding tools.

PubMed

Arnone, Mario; Koppisch, Dorothea; Smola, Thomas; Gabriel, Stefan; Verbist, Koen; Visser, Remco

2015-10-01

Many control banding tools use hazard banding in risk assessments for the occupational handling of hazardous substances. The outcome of these assessments can be combined with advice for the required risk management measures (RMMs). The Globally Harmonised System of Classification and Labelling of Chemicals (GHS) has resulted in a change in the hazard communication elements, i.e. Hazard (H) statements instead of Risk-phrases. Hazard banding schemes that depend on the old form of safety information have to be adapted to the new rules. The purpose of this publication is to outline the rationales for the assignment of hazard bands to H statements under the GHS. Based on this, this publication proposes a hazard banding scheme that uses the information from the safety data sheets as the basis for assignment. The assignment of hazard bands tiered according to the severity of the underlying hazards supports the important principle of substitution. Additionally, the set of assignment rules permits an exposure-route-specific assignment of hazard bands, which is necessary for the proposed route-specific RMMs. Ideally, all control banding tools should apply the same assignment rules. This GHS-compliant hazard banding scheme can hopefully help to establish a unified hazard banding strategy in the various control banding tools. Copyright © 2015 Elsevier Inc. All rights reserved.

Effects of Requiring Students to Meet High Expectation Levels within an On-Line Homework Environment

ERIC Educational Resources Information Center

Weber, William J., Jr.

2010-01-01

On-line homework is becoming a larger part of mathematics classrooms each year. Thus, ways to maximize the effectiveness of on-line homework for both students and teachers must be investigated. This study sought to provide one possible answer to this aim, by requiring students to achieve at least 50% for any on-line homework assignment in order to…

Learning in the School Workplace: Knowledge Acquisition and Modelling in Preparatory Vocational Secondary Education

ERIC Educational Resources Information Center

van Schaik, Martijn; van Oers, Bert; Terwel, Jan

2010-01-01

This paper addresses the composite question of whether it is better in vocational education to allow students to design their own models and guide them while doing so, or to provide them with ready-made models. To answer this question we set up a design experiment in which students were asked to work on real-life assignments, guided by teachers in…

DefenseLink Feature: Chairman Visits Japan and Republic of Korea, Nov. 5-8,

Science.gov Websites

Staff Navy Adm. Michael G. Mullen answers questions at a press availability with local media following Staff Navy Adm. Michael G. Mullen visits greets marines and staff assigned to the U.S. Embassy, Tokyo the Joint Chiefs of Staff U.S. Navy Adm. Michael G. Mullen, right, and Japanese Chief of Defense Adm

An overview of the BIOASQ large-scale biomedical semantic indexing and question answering competition.

PubMed

Tsatsaronis, George; Balikas, Georgios; Malakasiotis, Prodromos; Partalas, Ioannis; Zschunke, Matthias; Alvers, Michael R; Weissenborn, Dirk; Krithara, Anastasia; Petridis, Sergios; Polychronopoulos, Dimitris; Almirantis, Yannis; Pavlopoulos, John; Baskiotis, Nicolas; Gallinari, Patrick; Artiéres, Thierry; Ngomo, Axel-Cyrille Ngonga; Heino, Norman; Gaussier, Eric; Barrio-Alvers, Liliana; Schroeder, Michael; Androutsopoulos, Ion; Paliouras, Georgios

2015-04-30

This article provides an overview of the first BIOASQ challenge, a competition on large-scale biomedical semantic indexing and question answering (QA), which took place between March and September 2013. BIOASQ assesses the ability of systems to semantically index very large numbers of biomedical scientific articles, and to return concise and user-understandable answers to given natural language questions by combining information from biomedical articles and ontologies. The 2013 BIOASQ competition comprised two tasks, Task 1a and Task 1b. In Task 1a participants were asked to automatically annotate new PUBMED documents with MESH headings. Twelve teams participated in Task 1a, with a total of 46 system runs submitted, and one of the teams performing consistently better than the MTI indexer used by NLM to suggest MESH headings to curators. Task 1b used benchmark datasets containing 29 development and 282 test English questions, along with gold standard (reference) answers, prepared by a team of biomedical experts from around Europe and participants had to automatically produce answers. Three teams participated in Task 1b, with 11 system runs. The BIOASQ infrastructure, including benchmark datasets, evaluation mechanisms, and the results of the participants and baseline methods, is publicly available. A publicly available evaluation infrastructure for biomedical semantic indexing and QA has been developed, which includes benchmark datasets, and can be used to evaluate systems that: assign MESH headings to published articles or to English questions; retrieve relevant RDF triples from ontologies, relevant articles and snippets from PUBMED Central; produce "exact" and paragraph-sized "ideal" answers (summaries). The results of the systems that participated in the 2013 BIOASQ competition are promising. In Task 1a one of the systems performed consistently better from the NLM's MTI indexer. In Task 1b the systems received high scores in the manual evaluation of the "ideal" answers; hence, they produced high quality summaries as answers. Overall, BIOASQ helped obtain a unified view of how techniques from text classification, semantic indexing, document and passage retrieval, question answering, and text summarization can be combined to allow biomedical experts to obtain concise, user-understandable answers to questions reflecting their real information needs.

Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein.

PubMed

Massiah, M A; Starich, M R; Paschall, C; Summers, M F; Christensen, A M; Sundquist, W I

1994-11-25

The HIV-1 matrix protein forms an icosahedral shell associated with the inner membrane of the mature virus. Genetic analyses have indicated that the protein performs important functions throughout the viral life-cycle, including anchoring the transmembrane envelope protein on the surface of the virus, assisting in viral penetration, transporting the proviral integration complex across the nuclear envelope, and localizing the assembling virion to the cell membrane. We now report the three-dimensional structure of recombinant HIV-1 matrix protein, determined at high resolution by nuclear magnetic resonance (NMR) methods. The HIV-1 matrix protein is the first retroviral matrix protein to be characterized structurally and only the fourth HIV-1 protein of known structure. NMR signal assignments required recently developed triple-resonance (1H, 13C, 15N) NMR methodologies because signals for 91% of 132 assigned H alpha protons and 74% of the 129 assignable backbone amide protons resonate within chemical shift ranges of 0.8 p.p.m. and 1 p.p.m., respectively. A total of 636 nuclear Overhauser effect-derived distance restraints were employed for distance geometry-based structure calculations, affording an average of 13.0 NMR-derived distance restraints per residue for the experimentally constrained amino acids. An ensemble of 25 refined distance geometry structures with penalties (sum of the squares of the distance violations) of 0.32 A2 or less and individual distance violations under 0.06 A was generated; best-fit superposition of ordered backbone heavy atoms relative to mean atom positions afforded root-mean-square deviations of 0.50 (+/- 0.08) A. The folded HIV-1 matrix protein structure is composed of five alpha-helices, a short 3(10) helical stretch, and a three-strand mixed beta-sheet. Helices I to III and the 3(10) helix pack about a central helix (IV) to form a compact globular domain that is capped by the beta-sheet. The C-terminal helix (helix V) projects away from the beta-sheet to expose carboxyl-terminal residues essential for early steps in the HIV-1 infectious cycle. Basic residues implicated in membrane binding and nuclear localization functions cluster about an extruded cationic loop that connects beta-strands 1 and 2. The structure suggests that both membrane binding and nuclear localization may be mediated by complex tertiary structures rather than simple linear determinants.

An Intelligent Personalized e-Assessment Tool Developed and Implemented for a Greek Lyric Poetry Undergraduate Course

ERIC Educational Resources Information Center

Xanthou, Maria

2013-01-01

The scope of this paper is to present the development of a web-based evaluation system that adjusts to the level of knowledge of each student. The underlying concept is to split the questions into pools (bins) of distinct difficulty at the same time assigning a different level of accuracy to each possible answer that the student may select. Given…

How Do General Chemistry Students' Impressions, Attitudes, Perceived Learning, and Course Performance Vary with the Arrangement of Homework Questions and E-Text?

ERIC Educational Resources Information Center

Williamson, Vickie M.; Zumalt, Caitlin J.

2017-01-01

Two large sections of first-semester general chemistry were assigned to use different homework systems. One section used MindTap, a Cengage Learning product, which presents short sections of the textbook with embedded homework questions; such that students could read the textbook section then answer one or more questions in the same screen. The…

Coding Manual for the U.S. Army Aviation Epidemiology Data Register

DTIC Science & Technology

1991-01-01

procedures are indexed under Complications. 3. Late effects of cerebral infections, cerebrovascular lesions, injuries (e.g., fractures , dislocations, open...Examples: - Coronary artery bypass - Fitting of prosthetic leg - Lithotripsy - Cholecystectomy Step 2: Look up the item in the alphabetic index and...pertain to the main term. In the following exam- ples, use the notes to assign the appropriate tentative code. Answer - Greenstick fracture of the shaft

Does the Arrangement of Embedded Text versus Linked Text in Homework Systems Make a Difference in Students Impressions, Attitudes, and Perceived Learning?

ERIC Educational Resources Information Center

Zumalt, Caitlin J.; Williamson, Vickie M.

2016-01-01

Students in a first-semester general chemistry course at a large southwestern university completed a 3-week homework assignment using MindTap, a Cengage Learning product. MindTap is the first major electronic system that has homework questions embedded in the text, such that students read a short section of the textbook and then answer a question…

Facet Annotation by Extending CNN with a Matching Strategy.

PubMed

Wu, Bei; Wei, Bifan; Liu, Jun; Guo, Zhaotong; Zheng, Yuanhao; Chen, Yihe

2018-06-01

Most community question answering (CQA) websites manage plenty of question-answer pairs (QAPs) through topic-based organizations, which may not satisfy users' fine-grained search demands. Facets of topics serve as a powerful tool to navigate, refine, and group the QAPs. In this work, we propose FACM, a model to annotate QAPs with facets by extending convolution neural networks (CNNs) with a matching strategy. First, phrase information is incorporated into text representation by CNNs with different kernel sizes. Then, through a matching strategy among QAPs and facet label texts (FaLTs) acquired from Wikipedia, we generate similarity matrices to deal with the facet heterogeneity. Finally, a three-channel CNN is trained for facet label assignment of QAPs. Experiments on three real-world data sets show that FACM outperforms the state-of-the-art methods.

Web-based Homework and Quiz Systems

NASA Astrophysics Data System (ADS)

Pritchard, David

2005-05-01

Mastering Physics is a Socratic tutor designed to help students learn introductory physics. The tutor poses problems and then comments specifically on about 1/2 of all wrong answers, even though most responses demanded are analytic expressions. Students can request hints (some of which are sub-problems), and work through the list of hint titles at random. In a typical problem there are 10 round trip interactions between tutor and student, raising the percentage of students who get the answer from ˜60% on the first try to over 90% after tutoring. This is Mastery Learning where student time and effort are increased to achieve learning rather than the grade decreased to indicate that the learning is incomplete. Mastering Physics is also a homework administration system that aids the instructor in preparing an assignment by indicating (in the problem library) the difficulty and duration of each problem and of the overall assignment. At MIT doing Mastering Physics has been shown to correlate much better than written homework or going to recitation with scoring better on the final exam in May than that student did on the final in December (which is why the student was repeating the course in the spring). At Arizona State, Mastering Physics increased the class' normalized gain on the Force Concept Inventory from 21% to 40% the year it was introduced.

Interactions between children with juvenile rheumatoid arthritis and their mothers.

PubMed

Power, Thomas G; Dahlquist, Lynnda M; Thompson, Suzanne M; Warren, Robert

2003-01-01

To determine the degree to which mothers of children with juvenile rheumatoid arthritis (JRA) show an overprotective or highly controlling interaction style. We videotaped 84 mother-child pairs (42 JRA and 42 healthy, ages 6 to 13) while working on a collaborative problem-solving task. Based on physical therapy evaluations, children in the JRA group were assigned to "more severe" (n = 19) and "milder" (n = 22) arthritis subgroups. Results showed numerous differences between mothers of children with more severe arthritis and the other mothers (no differences between the milder arthritis and healthy comparison groups were found). Compared to mothers in the other two groups, mothers of children with more severe arthritis were more directive of their children's behavior during the task, showing higher rates of structure and rule setting, general clues, and prompting the child for an answer. Sequential analyses showed that mothers in the more severe group appeared to treat the task in a more evaluative manner, being more likely than other mothers to respond to correct answers with positive feedback and to incorrect answers with structure and rule setting. Mothers in the other groups were more likely to respond to both correct and incorrect answers with specific clues. We discuss how these differences in interactional style might impact the social development of children with JRA.

Assessment of Learning Gains Associated with Independent Exam Analysis in Introductory Biology

PubMed Central

William, Adrienne E.; Aguilar-Roca, Nancy M.; Tsai, Michelle; Wong, Matthew; Beaupré, Marin Moravec; O’Dowd, Diane K.

2011-01-01

This study evaluates the impact of an independent postmidterm question analysis exercise on the ability of students to answer subsequent exam questions on the same topics. It was conducted in three sections (∼400 students/section) of introductory biology. Graded midterms were returned electronically, and each student was assigned a subset of questions answered incorrectly by more than 40% of the class to analyze as homework. The majority of questions were at Bloom's application/analysis level; this exercise therefore emphasized learning at these higher levels of cognition. Students in each section answered final exam questions matched by topic to all homework questions, providing a within-class control group for each question. The percentage of students who correctly answered the matched final exam question was significantly higher (p < 0.05) in the Topic Analysis versus Control Analysis group for seven of 19 questions. We identified two factors that influenced activity effectiveness: 1) similarity in topic emphasis of the midterm–final exam question pair and 2) quality of the completed analysis homework. Our data suggest that this easy-to-implement exercise will be useful in large-enrollment classes to help students develop self-regulated learning skills. Additional strategies to help introductory students gain a broader understanding of topic areas are discussed. PMID:22135369

Assessment of learning gains associated with independent exam analysis in introductory biology.

PubMed

Williams, Adrienne E; William, Adrienne E; Aguilar-Roca, Nancy M; Tsai, Michelle; Wong, Matthew; Beaupré, Marin Moravec; O'Dowd, Diane K

2011-01-01

This study evaluates the impact of an independent postmidterm question analysis exercise on the ability of students to answer subsequent exam questions on the same topics. It was conducted in three sections (∼400 students/section) of introductory biology. Graded midterms were returned electronically, and each student was assigned a subset of questions answered incorrectly by more than 40% of the class to analyze as homework. The majority of questions were at Bloom's application/analysis level; this exercise therefore emphasized learning at these higher levels of cognition. Students in each section answered final exam questions matched by topic to all homework questions, providing a within-class control group for each question. The percentage of students who correctly answered the matched final exam question was significantly higher (p < 0.05) in the Topic Analysis versus Control Analysis group for seven of 19 questions. We identified two factors that influenced activity effectiveness: 1) similarity in topic emphasis of the midterm-final exam question pair and 2) quality of the completed analysis homework. Our data suggest that this easy-to-implement exercise will be useful in large-enrollment classes to help students develop self-regulated learning skills. Additional strategies to help introductory students gain a broader understanding of topic areas are discussed.

A Dyadic Interactive Approach to the Study of Leader Behavior

DTIC Science & Technology

1975-07-01

supervisors and workers in a bogus greeting card company performed experimental tasks involving construction of " origami " cranes. The following variables...comprised of a supervisor and three workers who, in turn, were assigned the task of producing " origami " paper cranes and were paid on a piece-rate basis...behaviors as he inter- acted with his followers. Experimental Task The experimental task involved the construction of " origami " cranes from sheets of

Work assignments, delegation of tasks and job satisfaction among Danish dental hygienists.

PubMed

Hach, M; Aaberg, K B; Lempert, S M; Danielsen, B

2017-08-01

Recent legislation in Denmark has made it possible for dentists to delegate their tasks to dental hygienists. Previous studies have shown that Danish dental hygienists primarily were performing assignments within their own work field. These assignments include prophylaxis or instructing patients in oral health care. However, studies have also shown that Danish dental hygienists performed dental nurse assignments such as chair-side assistance, unit cleaning and disinfection of instruments. The objectives of this study were to investigate (i) the range of work assignments performed by Danish dental hygienists, (ii) the types of dentist tasks performed by Danish dental hygienists and (iii) job satisfaction among Danish dental hygienists. Dental hygienists graduating in 2004-2007 were invited to participate in this study. Participants answered an email-distributed questionnaire. The questionnaire consisted of questions regarding job satisfaction, assignments performed, postgraduate course attendance, receiving assistance from a dental nurse and which work assignments Danish dental hygienists wish to perform in the future. The results of this study showed that 90% of Danish dental hygienists were satisfied with their job and 52% were performing dentists' tasks. Among dentists' tasks performed by Danish dental hygienists, invasive caries therapy was the most frequently performed task. The type of assignments performed by Danish dental hygienists today appears to be changing compared to previous studies. From initially performing prophylaxis and chair-side assistance for the dentist, Danish dental hygienists today are performing a wider range of tasks which includes dentists' tasks. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Usefulness of FTIR spectroscopy to distinguish rough and smooth variants of Lactobacillus farciminis CNCM-I-3699.

PubMed

Tareb, R; Bernardeau, M; Amiel, C; Vernoux, J P

2017-02-01

In this study, the potential of Fourier transform infrared (FTIR) spectroscopy for assessing putative biochemical and structural differences between the two variants, rough (R) and smooth (S), of Lactobacillus farciminis CNCM-I-3699, a pleomorphic strain, was investigated. The main differences observed were localized in the polysaccharide (1200-900 cm-1) and protein (1700-1500 cm-1) regions. Based on spectral information in these two spectral ranges, clustering resulted in a dendrogram that showed a clear discrimination between both morphotypes. Significant increases in favor of morphotype S compared to R at specific wavenumbers for polysaccharides (22.18% vs. 5.24% at 1068 cm-1) and capsular polysaccharides (16% vs. 13.17% at 1048 cm-1) were recorded. Compared to S, the morphotype R exhibits a 1.27-fold higher signal at the wavenumber of 1637 cm-1 assigned to the amide I β-sheet and a 2.71-fold higher signal at the wavenumber of 1513 cm-1 assigned to the tyrosine involved in the β-sheet arrangement of proteins. The FTIR analysis is efficient to separate and give data on mainly surface component differences observed previously between S colony morphotype (ropy and exopolysaccharide positive) and the R colony morphotype (non-ropy but highly autoaggregative). © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Comparison of efficacy of silicone gel, silicone gel sheeting, and topical onion extract including heparin and allantoin for the treatment of postburn hypertrophic scars.

PubMed

Karagoz, Huseyin; Yuksel, Fuat; Ulkur, Ersin; Evinc, Rahmi

2009-12-01

We compared the efficacy of silicone gel (Scarfade), silicone gel sheet (Epi-Derm), and topical onion extract including heparin and allantoin (Contractubex) for the treatment of hypertrophic scars. Forty-five postburn scars were included in the study. Patients with scars less than 6 months from injury were assigned at random to three groups each containing 15 scars, and their treatment was continued for 6 months. Scars were treated with Scarfade, Epiderm and Contractubex. Scar assessment was performed at the beginning of the treatment, and at the end of the sixth month when the treatment was completed by using the Vancouver scar scale. The difference between before and after treatment scores for each three groups was statistically significant. The difference between Scarfade group and Epi-Derm group was not significant; however, the differences of the other groups (Scarfade-Contractubex, Epiderm-Contractubex) were significant. Silicone products, either in gel or sheet, are superior to Contractubex in the treatment of the hypertrophic scar. The therapist should select the most appropriate agent according to the patient's need and guidelines of these signs.

Retrieval attempts enhance learning, but retrieval success (versus failure) does not matter.

PubMed

Kornell, Nate; Klein, Patricia Jacobs; Rawson, Katherine A

2015-01-01

Retrieving information from memory enhances learning. We propose a 2-stage framework to explain the benefits of retrieval. Stage 1 takes place as one attempts to retrieve an answer, which activates knowledge related to the retrieval cue. Stage 2 begins when the answer becomes available, at which point appropriate connections are strengthened and inappropriate connections may be weakened. This framework raises a basic question: Does it matter whether Stage 2 is initiated via successful retrieval or via an external presentation of the answer? To test this question, we asked participants to attempt retrieval and then randomly assigned items (which were equivalent otherwise) to be retrieved successfully or to be copied (i.e., not retrieved). Experiments 1, 2, 4, and 5 tested assumptions necessary for interpreting Experiments 3a, 3b, and 6. Experiments 3a, 3b, and 6 did not support the hypothesis that retrieval success produces more learning than does retrieval failure followed by feedback. It appears that retrieval attempts promote learning but retrieval success per se does not. PsycINFO Database Record (c) 2015 APA, all rights reserved.

Use of a Mobile Device Simulation as a Preclass Active Learning Exercise.

PubMed

Keegan, Robert D; Oliver, M Cecile; Stanfill, Teresa J; Stevens, Kevin V; Brown, Gary R; Ebinger, Michael; Gay, John M

2016-01-01

Research shows that preclass activities introducing new material can increase student performance. In an effort to engage students in an active learning, preclass activity, the authors developed a mobile application. Eighty-four nursing students were assigned a preclass reading exercise, whereas 32 students completed the preclass simulation scenario on their mobile device. All students completed the same electronic fetal monitoring (EFM) quiz 1 week following the lecture. The effects of reading or simulation on student quiz performance was evaluated with a student's paired t test, using an alpha of .05. Students completing the preclass simulation scored higher on the EFM quiz, compared with students assigned the preclass reading (85% versus 70% correct answers, p = .01). Student survey data indicated that the mobile device simulation was perceived as an engaging and desirable instructional tool. Nursing students completing the mobile device EFM preclass simulation outperformed the students who were given the traditional reading assignment. Copyright 2016, SLACK Incorporated.

On the stabilizability of multivariable systems by minimum order compensation

NASA Technical Reports Server (NTRS)

Byrnes, C. I.; Anderson, B. D. O.

1983-01-01

In this paper, a derivation is provided of the necessary condition, mp equal to or greater than n, for stabilizability by constant gain feedback of the generic degree n, p x m system. This follows from another of the main results, which asserts that generic stabilizability is equivalent to generic solvability of a deadbeat control problem, provided mp equal to or less than n. Taken together, these conclusions make it possible to make some sharp statements concerning minimum order stabilization. The techniques are primarily drawn from decision algebra and classical algebraic geometry and have additional consequences for problems of stabilizability and pole-assignability. Among these are the decidability (by a Sturm test) of the equivalence of generic pole-assignability and generic stabilizability, the semi-algebraic nature of the minimum order, q, of a stabilizing compensator, and the nonexistence of formulae involving rational operations and extraction of square roots for pole-assigning gains when they exist, answering in the negative a question raised by Anderson, Bose, and Jury (1975).

Cell replacement and visual restoration by retinal sheet transplants

PubMed Central

Seiler, Magdalene J.; Aramant, Robert B.

2012-01-01

Retinal diseases such as age-related macular degeneration (ARMD) and retinitis pigmentosa (RP) affect millions of people. Replacing lost cells with new cells that connect with the still functional part of the host retina might repair a degenerating retina and restore eyesight to an unknown extent. A unique model, subretinal transplantation of freshly dissected sheets of fetal-derived retinal progenitor cells, combined with its retinal pigment epithelium (RPE), has demonstrated successful results in both animals and humans. Most other approaches are restricted to rescue endogenous retinal cells of the recipient in earlier disease stages by a ‘nursing’ role of the implanted cells and are not aimed at neural retinal cell replacement. Sheet transplants restore lost visual responses in several retinal degeneration models in the superior colliculus (SC) corresponding to the location of the transplant in the retina. They do not simply preserve visual performance – they increase visual responsiveness to light. Restoration of visual responses in the SC can be directly traced to neural cells in the transplant, demonstrating that synaptic connections between transplant and host contribute to the visual improvement. Transplant processes invade the inner plexiform layer of the host retina and form synapses with presumable host cells. In a Phase II trial of RP and ARMD patients, transplants of retina together with its RPE improved visual acuity. In summary, retinal progenitor sheet transplantation provides an excellent model to answer questions about how to repair and restore function of a degenerating retina. Supply of fetal donor tissue will always be limited but the model can set a standard and provide an informative base for optimal cell replacement therapies such as embryonic stem cell (ESC)-derived therapy. PMID:22771454

East Europe Report. Economic and Industrial Affairs No. 2437.

DTIC Science & Technology

1983-08-17

considerable attention at exhibitions in Hungary, including also the Budapest International Fair. The showroom that opened this year on Ors Vezer Square...quickly became popular. One reason for this is the display of Soviet cars. What role do you intend to assign the showroom in the future, and what...exhibitions will be held there? [Answer] The showroom for displaying Soviet commodities features 450 square meters of floorspace and 600 square meters of

Temporal Codes for Memories: Issues and Problems.

DTIC Science & Technology

1977-04-01

for specific dates they were quite unable to reconstruct the dates. It has been reported (Gibson & Levin, 197S) that children afflicted with dyslexia ...used. Two answers predominated. First, a verbal label was used for the first item, and a "last" label was used by some subjects for the last item...this being assigned when the list terminated. Some subjects indicated that more general labels were used for several items, such phrases as the

Building and Retaining the Career Force: New Procedures for Accessing and Assigning Army Enlisted Personnel: Annual Report 1990 Fiscal Year

DTIC Science & Technology

1992-05-01

researched, valid measure of general cognitive abilities. However, many critical Army tasks appear to require psychomotor and perceptual skills for their...temperament (achievement, discipline, stress toler- ance), psychomotor ability (e.g., eye-hand coordination), and spatial ability to job performance...answered: (1) What combinations of aptitude, temperament, psychomotor ability, and spatial ability, measured at or before entry into the Army, best

Dehydration of main-chain amides in the final folding step of single-chain monellin revealed by time-resolved infrared spectroscopy

PubMed Central

Kimura, Tetsunari; Maeda, Akio; Nishiguchi, Shingo; Ishimori, Koichiro; Morishima, Isao; Konno, Takashi; Goto, Yuji; Takahashi, Satoshi

2008-01-01

Kinetic IR spectroscopy was used to reveal β-sheet formation and water expulsion in the folding of single-chain monellin (SMN) composed of a five-stranded β-sheet and an α-helix. The time-resolved IR spectra between 100 μs and 10 s were analyzed based on two consecutive intermediates, I1 and I2, appearing within 100 μs and with a time constant of ≈100 ms, respectively. The initial unfolded state showed broad amide I′ corresponded to a fluctuating conformation. In contrast, I1 possessed a feature at 1,636 cm−1 for solvated helix and weak features assignable to turns, demonstrating the rapid formation of helix and turns. I2 possessed a line for solvated helix at 1,637 cm−1 and major and minor lines for β-sheet at 1,625 and 1,680 cm−1, respectively. The splitting of the major and minor lines is smaller than that of the native state, implying an incomplete formation of the β-sheet. Furthermore, both major and minor lines demonstrated a low-frequency shift compared to those of the native state, which was interpreted to be caused by hydration of the CO group in the β-sheet. Together with the identification of solvated helix, the core domain of I2 was interpreted as being hydrated. Finally, slow conversion of the water-penetrated core of I2 to the dehydrated core of the native state was observed. We propose that both the expulsion of water, hydrogen-bonded to main-chain amides, and the completion of the secondary structure formation contribute to the energetic barrier of the rate-limiting step in SMN folding. PMID:18757727

Interface between hospital and fire authorities--a concept for management of incidents in hospitals.

PubMed

Gretenkort, Peter; Harke, Henning; Blazejak, Jan; Pache, Bernd; Leledakis, Georgios

2002-01-01

Although every hospital needs a security plan for the support of immobile patients who do not possess autonomous escape capabilities, little information exists to assist in the development of practical patient evacuation methods. 1) In hospitals during disasters, incident leadership of the fire authorities can be supported effectively by hospital executives experienced in the management of mass casualties; and 2) As an alternative for canvas carry sheets, rescue drag sheets can be employed for emergency, elevator-independent, patient evacuation. A hospital evacuation exercise was planned and performed to obtain experiences in incident command and to permit calculation of elevator-independent patient transport times. Performance of incident leadership was observed by means of pre-defined checklists. The effectiveness and efficiency of carrying teams with five persons each were compared to those with a rescue drag sheet employed by a single person. Incident command for hospitals during a disaster is enhanced considerably by pre-defined and trained executives who are placed at the immediate disposal of the fire authorities. For elevator-independent patient transport, the rescue drag sheet was superior to conventional carrying measures because of a reduced number of transport personnel required to move each patient. With this method, patient transport times averaged 54 m/min. flat and 18 seconds for one floor descent. Experiences from a hospital during an evacuation exercise provided decision criteria for changes in the disaster preparedness plan. Hospital incident leadership was assigned to executives-in-charge in close co-operation with the fire authorities. All beds were equipped with a rescue drag sheet. Both concepts may help to cope with an emergency evacuation of a hospital.

Higher-order molecular packing in amyloid-like fibrils constructed with linear arrangements of hydrophobic and hydrogen-bonding side-chains.

PubMed

Saiki, Masatoshi; Honda, Shinya; Kawasaki, Kazunori; Zhou, Deshan; Kaito, Akira; Konakahara, Takeo; Morii, Hisayuki

2005-05-13

Various mutants of the protein fragment, barnase module-1 (1-24) were investigated in order to reveal the structural principle of amyloid-like fibrils. By means of circular dichroism spectroscopy, X-ray diffraction, electron microscopy, and thioflavin T binding assay, we found that the molecules containing two beta-strands and an intervening turn structure are assembled to form a cross-beta structure. Stabilization by both the hydrophobic interactions and hydrogen bonding between the respective paired side-chains on the coupled beta-strands was essential for fibril formation. These two types of interaction can also arrange the corresponding residues in lines on both sheet surfaces of protofilaments with a cross-beta structure. This leads to the most probable fibril structure constructed with the line-matching interactions between protofilaments. Consideration of the geometrical symmetry resulted in our finding that a limited number of essential models for molecular packing in fibril structure are stable, which would rationally explain the occurrence of two or three morphologies from an identical molecular species. The ribbon-like fibrils exhibited striped texture along the axis, which was assigned to a stacked two-sheet repeat as a structural unit. The comprehensively proposed structural model, that is, the sheet-sheet interaction between left-handed cross-beta structures, results in a slightly right-handed twist of beta-sheet stacking, which reasonably elucidates the intrinsic sizes of the fibril width and its helical period along the fibril axis, as the bias in the orientation of the hydrogen-bonded beta-strand pair at the lateral edge is larger than that at the central protofilament.

The Cryosphere Model Comparison Tool (CmCt): Ice Sheet Model Validation and Comparison Tool for Greenland and Antarctica

NASA Astrophysics Data System (ADS)

Simon, E.; Nowicki, S.; Neumann, T.; Tyahla, L.; Saba, J. L.; Guerber, J. R.; Bonin, J. A.; DiMarzio, J. P.

2017-12-01

The Cryosphere model Comparison tool (CmCt) is a web based ice sheet model validation tool that is being developed by NASA to facilitate direct comparison between observational data and various ice sheet models. The CmCt allows the user to take advantage of several decades worth of observations from Greenland and Antarctica. Currently, the CmCt can be used to compare ice sheet models provided by the user with remotely sensed satellite data from ICESat (Ice, Cloud, and land Elevation Satellite) laser altimetry, GRACE (Gravity Recovery and Climate Experiment) satellite, and radar altimetry (ERS-1, ERS-2, and Envisat). One or more models can be uploaded through the CmCt website and compared with observational data, or compared to each other or other models. The CmCt calculates statistics on the differences between the model and observations, and other quantitative and qualitative metrics, which can be used to evaluate the different model simulations against the observations. The qualitative metrics consist of a range of visual outputs and the quantitative metrics consist of several whole-ice-sheet scalar values that can be used to assign an overall score to a particular simulation. The comparison results from CmCt are useful in quantifying improvements within a specific model (or within a class of models) as a result of differences in model dynamics (e.g., shallow vs. higher-order dynamics approximations), model physics (e.g., representations of ice sheet rheological or basal processes), or model resolution (mesh resolution and/or changes in the spatial resolution of input datasets). The framework and metrics could also be used for use as a model-to-model intercomparison tool, simply by swapping outputs from another model as the observational datasets. Future versions of the tool will include comparisons with other datasets that are of interest to the modeling community, such as ice velocity, ice thickness, and surface mass balance.

Use of Polypentapeptides of Elastin to Prevent Postoperative Adhesions: Efficacy in a Contaminated Peritoneal Model

DTIC Science & Technology

1994-02-01

short-gut syndrome, rotomy was conducted to reveal the cranial portion of chronic pain , and female infertility [3, 4]. Many sub- the ileum. The abdominal ...hold the sheets in the proper position. The presence of nal adhesions, chronic abdominal pain , and infertility. Gynecol. suture material acting as a...intra- abdominal landmarks. Opera- of 88 rats were studied with random assignment of ani- tions in this situation are often associated with mals to three

[IOL and aniseikonia calculation combined with documentation of surgical data and IOL inventory].

PubMed

Bastian, G O; Hiss, P

1992-08-01

The exact recording of operation data is a precondition for keeping the standards high in cataract surgery, but surgeons are reluctant to answer a questionnaire after a strenuous operation. We have designed a program easy to use in the Macintosh Hypercard System that covers all aspects of cataract surgery such as: (1) the operating record; (2) a data sheet for recording the various details of the operation; (3) recording of the data on hard disc; (4) managing the IOL stock list; (5) proposal of IOL models that are in stock with regard to IOL power (SRK2) and aniseiconia. This program enables the surgeon to record the operation data with effortless ease and it is well accepted. There is no dictation. The operating record and data sheet are printed immediately. The program is controlled by a "mouse". Selection of the suitable IOL model is facilitated by the link between the calculation of IOL power and the IOL stock list. In special cases the IOL power can be changed to obtain less aniseiconia.

The Value Question in Metaphysics.

PubMed

Kahane, Guy

2012-07-01

Much seems to be at stake in metaphysical questions about, for example, God, free will or morality. One thing that could be at stake is the value of the universe we inhabit-how good or bad it is. We can think of competing philosophical positions as describing possibilities, ways the world might turn out to be, and to which value can be assigned. When, for example, people hope that God exists, or fear that we do not possess free will, they express attitudes towards these possibilities, attitudes that presuppose answers to questions about their comparative value. My aim in this paper is to distinguish these evaluative questions from related questions with which they can be confused, to identify structural constraints on their proper pursuit, and to address objections to their very coherence. Answers to such evaluative questions offer one measure of the importance of philosophical disputes.

The GLAS Standard Data Products Specification--Level 2, Version 9. Volume 14

NASA Technical Reports Server (NTRS)

Lee, Jeffrey E.

2013-01-01

The Geoscience Laser Altimeter System (GLAS) is the primary instrument for the ICESat (Ice, Cloud and Land Elevation Satellite) laser altimetry mission. ICESat was the benchmark Earth Observing System (EOS) mission for measuring ice sheet mass balance, cloud and aerosol heights, as well as land topography and vegetation characteristics. From 2003 to 2009, the ICESat mission provided multi-year elevation data needed to determine ice sheet mass balance as well as cloud property information, especially for stratospheric clouds common over polar areas. It also provided topography and vegetation data around the globe, in addition to the polar-specific coverage over the Greenland and Antarctic ice sheets.This document defines the Level-2 GLAS standard data products. This document addresses the data flow, interfaces, record and data formats associated with the GLAS Level 2 standard data products. The term standard data products refers to those EOS instrument data that are routinely generated for public distribution. The National Snow and Ice Data Center (NSDIC) distribute these products. Each data product has a unique Product Identification code assigned by the Senior Project Scientist. The Level 2 Standard Data Products specifically include those derived geophysical data values (i.e., ice sheet elevation, cloud height, vegetation height, etc.). Additionally, the appropriate correction elements used to transform the Level 1A and Level 1B Data Products into Level 2 Data Products are included. The data are packaged with time tags, precision orbit location coordinates, and data quality and usage flags.

Geology of National Parks

USGS Publications Warehouse

Stoffer, Philip W.

2008-01-01

This is a set of two sheets of 3D images showing geologic features of many National Parks. Red-and-cyan viewing glasses are need to see the three-dimensional effect. A search on the World Wide Web will yield many sites about anaglyphs and where to get 3D glasses. Red-blue glasses will do but red-cyan glasses are a little better. This publication features a photo quiz game: Name that park! where you can explore, interpret, and identify selected park landscapes. Can you identify landscape features in the images? Can you explain processes that may have helped form the landscape features? You can get the answers online.

Comparing cluster-level dynamic treatment regimens using sequential, multiple assignment, randomized trials: Regression estimation and sample size considerations.

PubMed

NeCamp, Timothy; Kilbourne, Amy; Almirall, Daniel

2017-08-01

Cluster-level dynamic treatment regimens can be used to guide sequential treatment decision-making at the cluster level in order to improve outcomes at the individual or patient-level. In a cluster-level dynamic treatment regimen, the treatment is potentially adapted and re-adapted over time based on changes in the cluster that could be impacted by prior intervention, including aggregate measures of the individuals or patients that compose it. Cluster-randomized sequential multiple assignment randomized trials can be used to answer multiple open questions preventing scientists from developing high-quality cluster-level dynamic treatment regimens. In a cluster-randomized sequential multiple assignment randomized trial, sequential randomizations occur at the cluster level and outcomes are observed at the individual level. This manuscript makes two contributions to the design and analysis of cluster-randomized sequential multiple assignment randomized trials. First, a weighted least squares regression approach is proposed for comparing the mean of a patient-level outcome between the cluster-level dynamic treatment regimens embedded in a sequential multiple assignment randomized trial. The regression approach facilitates the use of baseline covariates which is often critical in the analysis of cluster-level trials. Second, sample size calculators are derived for two common cluster-randomized sequential multiple assignment randomized trial designs for use when the primary aim is a between-dynamic treatment regimen comparison of the mean of a continuous patient-level outcome. The methods are motivated by the Adaptive Implementation of Effective Programs Trial which is, to our knowledge, the first-ever cluster-randomized sequential multiple assignment randomized trial in psychiatry.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Driscoll, P.C.; Clore, G.M.; Beress, L.

The sequential resonance assignment of the {sup 1}H NMR spectrum of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata is presented. This is carried out with two-dimensional NMR techniques to identify through-bond and through-space (< 5{angstrom}) connectivities. Added spectral complexity arises from the fact that the sample is an approximately 1:1 mixture of two BDS-I isoproteins, (Leu-18)-BDS-I and (Phe-18)-BDS-I. Complete assignments, however, are obtained, largely due to the increased resolution and sensitivity afforded at 600 MHz. In addition, the stereospecific assignment of a large number of {beta}-methylene protons is achieved from an analysis of the patternmore » of {sup 3}J{sub {alpha}{beta}} coupling constants and the relative magnitudes of intraresidue NOEs involving the NH, C{sup {alpha}}H, and C{sup {beta}}H protons. Regular secondary structure elements are deduced from a qualitative interpretation of the nuclear Overhauser enhancement, {sup 3}J{sub HN{alpha}} coupling constant, and amide NH exchange data. A triple-stranded antiparallel {beta}-sheet is found to be related to that found in partially homologous sea anemone polypeptide toxins.« less

HealthScope: a model for a low cost health education program using commercial television.

PubMed Central

Braun, K L; Conybeare, C R

1995-01-01

HealthScope is a health education based on the Health Belief Model that uses television and print materials. It was designed for a number of agendas--(a) a desire by health educators to provide health information to a broad audience at a reasonable cost (b) a desire by the local medical association to promote its role in prevention and primary care, and (c) a desire by commercial television to expand its coverage of local health issues in a cost-effective way. In its summer series, HealthScope included 10 weekly television programs that focused on various aspects of disease prevention and health promotion and answered viewers' questions on the air. Each program was followed by a bank of physicians answering questions on the telephone for 90 minutes. Corresponding fact sheets were distributed through a local pharmacy chain. A "healthy weekend" sweepstakes contest also was held. Intermediate outcome measures indicated that HealthScope had a broad reach and stimulated viewers to seek additional information about health. At the same time, the program generated revenue for the commercial television station. PMID:7638337

Profile of student’s understanding in Kinetic Theory of Gases

NASA Astrophysics Data System (ADS)

Putri, E. E. R.; Sukarmin; Cari

2018-04-01

Students in eleven grade had a different style for answering the physics problems. They could do anything to solve the problem. The way they thought and revealed it into the answer in many styles could be used as a data to know their conception. One of the sub-chapter in physics was the effective velocity of gases. It included in Kinetic Theory of Gases. It was one of the most difficult scientific theories to accept. This research aimed to identify student’s understanding in effective velocity of gases problem. The research was qualitative research. It was taken place at MAN Yogyakarta I in semester two on grade eleven. The obtained datas were collected by test sheet that contained of essay form. The respondents were all of the students in XI MIA 3. The data was analyzed by quantitative analysis using rubric of scoring in essay test and it contained of two problems. The results were the students had resolved the test and it was divided into three categories which are high 10,42%, medium 29,17%, and low 50,00%.

Low-cost and high-speed optical mark reader based on an intelligent line camera

NASA Astrophysics Data System (ADS)

Hussmann, Stephan; Chan, Leona; Fung, Celine; Albrecht, Martin

2003-08-01

Optical Mark Recognition (OMR) is thoroughly reliable and highly efficient provided that high standards are maintained at both the planning and implementation stages. It is necessary to ensure that OMR forms are designed with due attention to data integrity checks, the best use is made of features built into the OMR, used data integrity is checked before the data is processed and data is validated before it is processed. This paper describes the design and implementation of an OMR prototype system for marking multiple-choice tests automatically. Parameter testing is carried out before the platform and the multiple-choice answer sheet has been designed. Position recognition and position verification methods have been developed and implemented in an intelligent line scan camera. The position recognition process is implemented into a Field Programmable Gate Array (FPGA), whereas the verification process is implemented into a micro-controller. The verified results are then sent to the Graphical User Interface (GUI) for answers checking and statistical analysis. At the end of the paper the proposed OMR system will be compared with commercially available system on the market.

Enhanced Understanding of the Levels of Palliative Care in Pharmacy Students Through Participating in Clinical Training in Hospitals.

PubMed

Myotoku, Michiaki; Omotani, Sachiko; Hatsuda, Yasutoshi; Konishi, Hiroki; Hirotani, Yoshihiko

2017-06-01

A palliative care knowledge survey was conducted involving pharmacy students to examine their perceived usefulness and the educational effect of clinical training in hospitals. A questionnaire sheet was distributed to fifth-year pharmacy students before and after clinical training. The questionnaire consisted of questions to clarify the details of palliative care-related training in hospitals and students' knowledge of such care. The respondents were divided into 2 groups: those who participated in palliative care team (PCT) rounds (group A: 57) and those who did not (group B: 57). The mean total correct answer rate markedly increased after training in group A, from 37.9 to 47.1% (P < .01). Such an increase was also observed in the domains of philosophy and pain in this group ( P < .01). In contrast, group B did not show differences in the mean correct answer rate between before and after training; there was no significant increase in the rate in any domain. Pharmacy students' knowledge was enhanced by participating in the PCT, confirming the usefulness of such participation during training as part of palliative care education.

Normalizing the performances of athletes in Olympic weightlifting.

PubMed

Sinclair, R G

1985-06-01

A method of comparing the performances of athletes of disparate bodyweights in Olympic weightlifting is developed that is able to accommodate the fact that, of the ten bodyweight classes contested, the lighter nine have upper limits assigned to them while the heaviest has only a lower limit. The results are presented so as to answer the question "What would a given athlete weighing x kilograms total if he were a +110 kg. athlete of the same level of ability?"

NASA's New Horizons Pluto Mission: Continuing Voyager's Legacy o

NASA Image and Video Library

2014-08-25

Dr. John Spencer, senior scientist at the Southwest Research Institute, answers a question from the audience during a panel discussion at the "NASA's New Horizons Pluto Mission: Continuing Voyager's Legacy of Exploration" event on Monday, August, 25, 2014, in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The panelists gave their accounts of Voyager's encounter with Neptune and discussed their current assignments on NASA's New Horizons mission to Pluto. Photo Credit: (NASA/Joel Kowsky)

Use of proline mutants to help solve the NMR solution structure of type III antifreeze protein.

PubMed Central

Chao, H.; Davies, P. L.; Sykes, B. D.; Sönnichsen, F. D.

1993-01-01

To help understand the structure/function relationships in antifreeze proteins (AFP), and to define the motifs required for ice binding, a Type III AFP suitable for two-dimensional (2D) NMR studies was produced in Escherichia coli. A synthetic gene for one of the Type III AFP isoforms was assembled in a T7 polymerase-directed expression vector. The 67-amino acid-long gene product differed from the natural AFP by inclusion of an N-terminal methionine but was indistinguishable in activity. The NMR spectra of this AFP were complicated by cis-trans proline isomerization from the C-terminal sequence YPPA. Substitution of this sequence by YAA eliminated isomer signals without altering the activity or structure of the mutant AFP. This variant (rQAE m1.1) was selected for sequential assignment and the secondary structure determination using 2D 1H NMR spectroscopy. Nine beta-strands are paired to form two triple-stranded antiparallel sheets and one double-stranded antiparallel sheet. Two further proline replacements, P29A and P33A, were made to delineate the role of conserved prolines in Type III AFP. These mutants were valuable in clarifying ambiguous NMR spectral assignments amongst the remaining six prolines of rQAE m1.1. In contrast to the replacement of the C-terminal prolyl residues, the exchange of P29 and P33 caused some structural changes and significantly decreased protein solubility and antifreeze activity. PMID:8401227

Using comprehension strategies with authentic text in a college chemistry course

NASA Astrophysics Data System (ADS)

Cain, Stephen Daniel

College science students learn important topics by reading textbooks, which contain dense technical prose. Comprehension strategies are known to increase learning from reading. One class of comprehension strategies, called elaboration strategies, is intended to link new information with prior knowledge. Elaboration strategies have an appeal in science courses where new information frequently depends on previously learned information. The purpose of this study was to determine the effectiveness of an elaboration strategy in an authentic college environment. General chemistry students read text about Lewis structures, figures drawn by chemists to depict molecules, while assigned to use either an elaboration strategy, namely elaborative interrogation, or another strategy, rereading, which served as a placebo control. Two texts of equal length were employed in this pretest-posttest experimental design. One was composed by the researcher. The other was an excerpt from a college textbook and contained a procedure for constructing Lewis structures. Students (N = 252) attending a large community college were randomly assigned to one of the two texts and assigned one of the two strategies. The elaborative interrogation strategy was implemented with instructions to answer why-questions posed throughout the reading. Answering why-questions has been hypothesized to activate prior knowledge of a topic, and thus to aid in cognitively connecting new material with prior knowledge. The rereading strategy was implemented with instructions to read text twice. The use of authentic text was one of only a few instances of applying elaborative interrogation with a textbook. In addition, previous studies have generally focused on the learning of facts contained in prose. The application of elaborative interrogation to procedural text has not been previously reported. Results indicated that the more effective strategy was undetermined when reading authentic text in this setting. However, prior knowledge level was identified as a statistically significant factor for learning from authentic text. That is, students with high prior knowledge learned more, regardless of assigned strategy. Another descriptive study was conducted with a separate student sample (N = 34). Previously reported Lewis structure research was replicated. The trend of difficulty for 50 structures in the earlier work was supported.

Finite Element Modeling and Analysis of Mars Entry Aeroshell Baseline Concept

NASA Technical Reports Server (NTRS)

Ahmed, Samee W.; Lane, Brittney M.

2017-01-01

The structure that is developed and analyzed in this project must be able to survive all the various load conditions that it will encounter along its course to Mars with the minimal amount of weight and material. At this stage, the goal is to study the capability of the structure using a finite element model (FEM). This FEM is created using a python script, and is numerically solved in Nastran. The purpose of the model is to achieve an optimization of mass given specific constraints on launch and entry. The generation and analysis of the baseline Rigid Mid-Range Lift to Drag Ratio Aeroshell model is a continuation and an improvement on previous work done for the FEM. The model is generated using Python programming with the axisymmetric placement of nodes for beam and shell elements. The shells are assigned a honeycomb sandwich material with an aluminum honeycomb core and composite face sheets, and the beams are assigned the same material as the shell face sheets. There are two load cases assigned to the model: Earth launch and Mars entry. The Earth launch case consists of pressure, gravity, and vibration loads, and the Mars entry case consists of just pressure and gravity loads. The Earth launch case was determined to be the driving case, though the analyses are performed for both cases to ensure the constraints are satisfied. The types of analysis performed with the model are design optimization, statics, buckling, normal modes, and frequency response, the last of which is only for the Earth launch load case. The final results indicated that all of the requirements are satisfied except the thermal limits, which could not yet be tested, and the normal modes for the Mars entry. However, the frequency limits during Mars entry are expected to be much higher than the lower frequency limits set for the analysis. In addition, there are still improvements that can be made in order to reduce the weight while still meeting all requirements.

Modeling Pluto's Ice-Rich Surface and Its Interaction with Atmosphere

NASA Astrophysics Data System (ADS)

Wei, Q.; Hu, Y.

2016-12-01

Recent discoveries made available through NASA's New Horizon mission revealed a new world on Pluto with a plateau of "young" surface, the Sputnik Planum. It is a gigantic reservoir of volatile ice on top of an impact basin. The reason of such a high level of concentration of volatile ice is yet unknown. We are actively looking into explanations through atmospheric models and ice sheet models. Apart from the quantity of ice on SP, its surface age constrained by impact flux models to under 10Myr is significantly different from other parts of Pluto. Convection of solid nitrogen ice has been proposed as a viable cause. We endeavor to explore other possibilities that may have jointly contributed to this phenomena, including atmospheric condensation, ice sheet evolution, etc. Unique rheological properties of nitrogen ice, which is thought to dominate the Sputnik Planum, may hold the key to answering our questions. They are soft and easy to deform under its own weight even at Pluto's surface temperature of around 40K. Based on our initial simulations with numerical ice sheet models, we propose that once a crater is created on the Sputnik Planum, deformation under internal stress kicks in as a primary mechanism to flatten out craters. This could be done in a time scale of 100,000 years, significantly shorter than the maximum surface age contrained by crater densitiess models. As the surface arpproaches a flat state, such mechanism becomes weaker. The surface feature is then dominated by convection.

Spectroscopic studies on the conformational transitions of a bovine growth hormone releasing factor analog

NASA Astrophysics Data System (ADS)

Sarver, Ronald W.; Friedman, Alan R.; Thamann, Thomas J.

1997-10-01

The secondary structure of the bovine growth hormone releasing factor analog, [Ile 2, Ser 8,28, Ala 15, Leu 27, Hse 30] bGRF(1-30)-NH-Ethyl, acetate salt (U-90699F) was studied in solution by Fourier transform infrared and Raman spectroscopies. Spectroscopic studies revealed that concentrated aqueous solutions of U-90699F (100 mg ml -1) undergo a secondary structure transition from disordered coil/α-helix to intermolecular β-sheet. Disordered coil and α-helical structure were grouped together in the infrared and Raman studies since the amide I vibrations are close in frequency and overlap in assignments was possible. Before the conformational transition, the facile exchange of the peptide's amide hydrogens for deuterium indicated that the majority of amide hydrogens were readily accessible to solvent. The kinetics of the conformational transition coincided with an increase in solution viscosity and turbidity. An initiation phase preceded the conformational transition during which only minor spectral changes were observed by infrared spectroscopy. The initiation phase and reaction kinetics were consistent with a highly cooperative nucleation ultimately leading to a network of intermolecular β-sheet structure and gel formation. Increased temperature accelerated the conformational transition. The conformational transition was thermally irreversible but the β-sheet structure of aggregated or gelled peptide could be disrupted by dilution and agitation.

Image Classification of Ribbed Smoked Sheet using Learning Vector Quantization

NASA Astrophysics Data System (ADS)

Rahmat, R. F.; Pulungan, A. F.; Faza, S.; Budiarto, R.

2017-01-01

Natural rubber is an important export commodity in Indonesia, which can be a major contributor to national economic development. One type of rubber used as rubber material exports is Ribbed Smoked Sheet (RSS). The quantity of RSS exports depends on the quality of RSS. RSS rubber quality has been assigned in SNI 06-001-1987 and the International Standards of Quality and Packing for Natural Rubber Grades (The Green Book). The determination of RSS quality is also known as the sorting process. In the rubber factones, the sorting process is still done manually by looking and detecting at the levels of air bubbles on the surface of the rubber sheet by naked eyes so that the result is subjective and not so good. Therefore, a method is required to classify RSS rubber automatically and precisely. We propose some image processing techniques for the pre-processing, zoning method for feature extraction and Learning Vector Quantization (LVQ) method for classifying RSS rubber into two grades, namely RSS1 and RSS3. We used 120 RSS images as training dataset and 60 RSS images as testing dataset. The result shows that our proposed method can give 89% of accuracy and the best perform epoch is in the fifteenth epoch.

Text Mining to Support Gene Ontology Curation and Vice Versa.

PubMed

Ruch, Patrick

2017-01-01

In this chapter, we explain how text mining can support the curation of molecular biology databases dealing with protein functions. We also show how curated data can play a disruptive role in the developments of text mining methods. We review a decade of efforts to improve the automatic assignment of Gene Ontology (GO) descriptors, the reference ontology for the characterization of genes and gene products. To illustrate the high potential of this approach, we compare the performances of an automatic text categorizer and show a large improvement of +225 % in both precision and recall on benchmarked data. We argue that automatic text categorization functions can ultimately be embedded into a Question-Answering (QA) system to answer questions related to protein functions. Because GO descriptors can be relatively long and specific, traditional QA systems cannot answer such questions. A new type of QA system, so-called Deep QA which uses machine learning methods trained with curated contents, is thus emerging. Finally, future advances of text mining instruments are directly dependent on the availability of high-quality annotated contents at every curation step. Databases workflows must start recording explicitly all the data they curate and ideally also some of the data they do not curate.

Risk Management Issues When Taking Locum Tenens Assignments.

PubMed

Cash, Charles D

2017-01-01

This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient outcomes and reduce professional liability risk. The answers published in this column represent those of only one risk management consulting company. Other risk management consulting companies or insurance carriers may provide different advice, and readers should take this into consideration. The information in this column does not constitute legal advice. For legal advice, contact your personal attorney. Note: The information and recommendations in this article are applicable to physicians and other healthcare professionals so "clinician" is used to indicate all treatment team members.

The Value Question in Metaphysics

PubMed Central

Kahane, Guy

2012-01-01

Much seems to be at stake in metaphysical questions about, for example, God, free will or morality. One thing that could be at stake is the value of the universe we inhabit—how good or bad it is. We can think of competing philosophical positions as describing possibilities, ways the world might turn out to be, and to which value can be assigned. When, for example, people hope that God exists, or fear that we do not possess free will, they express attitudes towards these possibilities, attitudes that presuppose answers to questions about their comparative value. My aim in this paper is to distinguish these evaluative questions from related questions with which they can be confused, to identify structural constraints on their proper pursuit, and to address objections to their very coherence. Answers to such evaluative questions offer one measure of the importance of philosophical disputes. PMID:23024399

Risk Management Issues When Taking Locum Tenens Assignments

PubMed Central

Cash, Charles D.

2017-01-01

This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient outcomes and reduce professional liability risk. The answers published in this column represent those of only one risk management consulting company. Other risk management consulting companies or insurance carriers may provide different advice, and readers should take this into consideration. The information in this column does not constitute legal advice. For legal advice, contact your personal attorney. Note: The information and recommendations in this article are applicable to physicians and other healthcare professionals so “clinician” is used to indicate all treatment team members. PMID:28386523

Two-dimensional sup 1 H NMR studies on HPr protein from Staphylococcus aureus: Complete sequential assignments and secondary structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalbitzer, H.R.; Neidig, K.P.; Hengstenberg, W.

1991-11-19

Complete sequence-specific assignments of the {sup 1}H NMR spectrum of HPr protein from Staphylococcus aureus were obtained by two-dimensional NMR methods. Important secondary structure elements that can be derived from the observed nuclear Overhauser effects are a large antiparallel {beta}-pleated sheet consisting of four strands, A, B, C, D, a segment S{sub AB} consisting of an extended region around the active-center histidine (His-15) and an {alpha}-helix, a half-turn between strands B and C, a segment S{sub CD} which shows no typical secondary structure, and the {alpha}-helical, C-terminal segment S{sub term}. These general structural features are similar to those found earliermore » in HPr proteins from different microorganisms such as Escherichia coli, Bacillus subtilis, and Streptococcus faecalis.« less

Teaching Theory in Occupational Therapy Using a Cooperative Learning: A Mixed-Methods Study.

PubMed

Howe, Tsu-Hsin; Sheu, Ching-Fan; Hinojosa, Jim

2018-01-01

Cooperative learning provides an important vehicle for active learning, as knowledge is socially constructed through interaction with others. This study investigated the effect of cooperative learning on occupational therapy (OT) theory knowledge attainment in professional-level OT students in a classroom environment. Using a pre- and post-test group design, 24 first-year, entry-level OT students participated while taking a theory course in their second semester of the program. Cooperative learning methods were implemented via in-class group assignments. The students were asked to complete two questionnaires regarding their attitudes toward group environments and their perception toward group learning before and after the semester. MANCOVA was used to examine changes in attitudes and perceived learning among groups. Students' summary sheets for each in-class assignment and course evaluations were collected for content analysis. Results indicated significant changes in students' attitude toward working in small groups regardless of their prior group experience.

Selected DOE headquarters publications

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1979-07-01

Selected DOE Headquarters Publications provides cumulative listings, from October 1, 1977 onward, of two groups of publications issued by headquarters organizations of the Department of Energy, and an index to their title keywords. The two groups consist of publications assigned a DOE/XXX-type report number code and headquarters contractor publications, prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department. Publications such as pamphlets, fact sheets, bulletins, newsletters, and telephone directories, are omitted, as are publications issued under the DOE-tr, CONF, DOE/JPL, and DOE/NASA codes. (RWR)

Archive of post-Hurricane Charley coastal oblique aerial photographs collected during U.S. Geological Survey field activity 04CCH01 from Marco Island to Fort DeSoto, Florida, August 15, 2004

USGS Publications Warehouse

Subino, Janice A.; Morgan, Karen L.M.; Krohn, M. Dennis; Miller, Gregory K.; Dadisman, Shawn V.; Forde, Arnell S.

2012-01-01

To view the survey maps and navigation files, and for more information about these items, see the Navigation page. Figure 1 displays the acquisition geometry. The tables provide detailed information about the assigned location, name, data, and time the photograph was taken along with links to the photo and corresponding 5-min contact sheet. Refer to table 1 and table 2 for details of the northern and southern county photographs, respectively.

Concept Model on Topological Learning

NASA Astrophysics Data System (ADS)

Ae, Tadashi; Kioi, Kazumasa

2010-11-01

We discuss a new model for concept based on topological learning, where the learning process on the neural network is represented by mathematical topology. The topological learning of neural networks is summarized by a quotient of input space and the hierarchical step induces a tree where each node corresponds to a quotient. In general, the concept acquisition is a difficult problem, but the emotion for a subject is represented by providing the questions to a person. Therefore, a kind of concept is captured by such data and the answer sheet can be mapped into a topology consisting of trees. In this paper, we will discuss a way of mapping the emotional concept to a topological learning model.

Do People Experience Cognitive Biases while Searching for Information?

PubMed Central

Lau, Annie Y.S.; Coiera, Enrico W.

2007-01-01

Objective To test whether individuals experience cognitive biases whilst searching using information retrieval systems. Biases investigated are anchoring, order, exposure and reinforcement. Design A retrospective analysis and a prospective experiment were conducted to investigate whether cognitive biases affect the way that documentary evidence is interpreted while searching online. The retrospective analysis was conducted on the search and decision behaviors of 75 clinicians (44 doctors, 31 nurses), answering questions for 8 clinical scenarios within 80 minutes in a controlled setting. The prospective study was conducted on 227 undergraduate students, who used the same search engine to answer two of six randomly assigned consumer health questions. Measurements Frequencies of correct answers pre- and post- search, and confidence in answers were collected. The impact of reading a document on the final decision was measured by the population likelihood ratio (LR) of the frequency of reading the document and the frequency of obtaining a correct answer. Documents with a LR > 1 were most likely to be associated with a correct answer, and those with a LR < 1 were most likely to be associated with an incorrect answer to a question. Agreement between a subject and the evidence they read was estimated by a concurrence rate, which measured the frequency that subjects’ answers agreed with the likelihood ratios of a group of documents, normalized for document order, time exposure or reinforcement through repeated access. Serial position curves were plotted for the relationship between subjects’ pre-search confidence, document order, the number of times and length of time a document was accessed, and concurrence with post-search answers. Chi-square analyses tested for the presence of biases, and the Kolmogorov-Smirnov test checked for equality of distribution of evidence in the comparison populations. Results A person’s prior belief (anchoring) has a significant impact on their post-search answer (retrospective: P < 0.001; prospective: P < 0.001). Documents accessed at different positions in a search session (order effect [retrospective: P = 0.76; prospective: P = 0.026]), and documents processed for different lengths of time (exposure effect [retrospective: P = 0.27; prospective: P = 0.0081]) also influenced decision post-search more than expected in the prospective experiment but not in the retrospective analysis. Reinforcement through repeated exposure to a document did not yield statistical differences in decision outcome post-search (retrospective: P = 0.31; prospective: P = 0.81). Conclusion People may experience anchoring, exposure and order biases while searching for information, and these biases may influence the quality of decision making during and after the use of information retrieval systems. PMID:17600097

Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome*

PubMed Central

Jadot, Michel; Boonen, Marielle; Thirion, Jaqueline; Wang, Nan; Xing, Jinchuan; Zhao, Caifeng; Tannous, Abla; Qian, Meiqian; Zheng, Haiyan; Everett, John K.; Moore, Dirk F.; Sleat, David E.; Lobel, Peter

2017-01-01

Accurate knowledge of the intracellular location of proteins is important for numerous areas of biomedical research including assessing fidelity of putative protein-protein interactions, modeling cellular processes at a system-wide level and investigating metabolic and disease pathways. Many proteins have not been localized, or have been incompletely localized, partly because most studies do not account for entire subcellular distribution. Thus, proteins are frequently assigned to one organelle whereas a significant fraction may reside elsewhere. As a step toward a comprehensive cellular map, we used subcellular fractionation with classic balance sheet analysis and isobaric labeling/quantitative mass spectrometry to assign locations to >6000 rat liver proteins. We provide quantitative data and error estimates describing the distribution of each protein among the eight major cellular compartments: nucleus, mitochondria, lysosomes, peroxisomes, endoplasmic reticulum, Golgi, plasma membrane and cytosol. Accounting for total intracellular distribution improves quality of organelle assignments and assigns proteins with multiple locations. Protein assignments and supporting data are available online through the Prolocate website (http://prolocate.cabm.rutgers.edu). As an example of the utility of this data set, we have used organelle assignments to help analyze whole exome sequencing data from an infant dying at 6 months of age from a suspected neurodegenerative lysosomal storage disorder of unknown etiology. Sequencing data was prioritized using lists of lysosomal proteins comprising well-established residents of this organelle as well as novel candidates identified in this study. The latter included copper transporter 1, encoded by SLC31A1, which we localized to both the plasma membrane and lysosome. The patient harbors two predicted loss of function mutations in SLC31A1, suggesting that this may represent a heretofore undescribed recessive lysosomal storage disease gene. PMID:27923875

Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome.

PubMed

Jadot, Michel; Boonen, Marielle; Thirion, Jaqueline; Wang, Nan; Xing, Jinchuan; Zhao, Caifeng; Tannous, Abla; Qian, Meiqian; Zheng, Haiyan; Everett, John K; Moore, Dirk F; Sleat, David E; Lobel, Peter

2017-02-01

Accurate knowledge of the intracellular location of proteins is important for numerous areas of biomedical research including assessing fidelity of putative protein-protein interactions, modeling cellular processes at a system-wide level and investigating metabolic and disease pathways. Many proteins have not been localized, or have been incompletely localized, partly because most studies do not account for entire subcellular distribution. Thus, proteins are frequently assigned to one organelle whereas a significant fraction may reside elsewhere. As a step toward a comprehensive cellular map, we used subcellular fractionation with classic balance sheet analysis and isobaric labeling/quantitative mass spectrometry to assign locations to >6000 rat liver proteins. We provide quantitative data and error estimates describing the distribution of each protein among the eight major cellular compartments: nucleus, mitochondria, lysosomes, peroxisomes, endoplasmic reticulum, Golgi, plasma membrane and cytosol. Accounting for total intracellular distribution improves quality of organelle assignments and assigns proteins with multiple locations. Protein assignments and supporting data are available online through the Prolocate website (http://prolocate.cabm.rutgers.edu). As an example of the utility of this data set, we have used organelle assignments to help analyze whole exome sequencing data from an infant dying at 6 months of age from a suspected neurodegenerative lysosomal storage disorder of unknown etiology. Sequencing data was prioritized using lists of lysosomal proteins comprising well-established residents of this organelle as well as novel candidates identified in this study. The latter included copper transporter 1, encoded by SLC31A1, which we localized to both the plasma membrane and lysosome. The patient harbors two predicted loss of function mutations in SLC31A1, suggesting that this may represent a heretofore undescribed recessive lysosomal storage disease gene. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Choice, numeracy, and physicians-in-training performance: the case of Medicare Part D.

PubMed

Hanoch, Yaniv; Miron-Shatz, Talya; Cole, Helen; Himmelstein, Mary; Federman, Alex D

2010-07-01

In this study, we examined the effect of choice-set size and numeracy levels on a physician-in-training's ability to choose appropriate Medicare drug plans. Medical students and internal medicine residents (N = 100) were randomly assigned to 1 of 3 surveys, differing only in the number of plans to be evaluated (3, 10, and 20). After reviewing information about stand-alone Medicare prescription drug plans, participants answered questions about what plan they would advise 2 hypothetical patients to choose on the basis of a brief summary of the relevant concerns of each patient. Participants also completed an 11-item numeracy scale. Ability to answer correctly questions about hypothetical Medicare Part D insurance plans and numeracy levels. Consistent with our hypotheses, increases in choice sets correlated significantly with fewer correct answers, and higher numeracy levels were associated with more correct answers. Hence, our data further highlight the role of numeracy in financial- and health-related decision making, and also raise concerns about physicians' ability to help patients choose the optimal Part D plan. Our data indicate that even physicians-in-training perform more poorly when choice size is larger, thus raising concerns about the capacity of physicians-in-training to successfully navigate Medicare Part D and help their patients pick the best drug plan. Our results also illustrate the importance of numeracy in evaluating insurance-related information and the need for enhancing numeracy skills among medical students and physicians. PsycINFO Database Record (c) 2010 APA, all rights reserved

Identification of Biomarkers for Footpad Dermatitis Development and Wound Healing

PubMed Central

Chen, Juxing; Tellez, Guillermo; Escobar, Jeffery

2016-01-01

Footpad dermatitis (FPD) is a type of skin inflammation that causes necrotic lesions on the plantar surface of the footpads in commercial poultry, with significant animal welfare, and economic implications. To identify biomarkers for FPD development and wound healing, a battery cage trial was conducted in which a paper sheet was put on the bottom of cages to hold feces to induce FPD of broilers. Day-of-hatch Ross 308 male broiler chicks were fed a corn–soybean meal diet and assigned to 3 treatments with 8 cages per treatment and 11 birds per cage. Cages without paper sheets were used as a negative control (NEG). Cages with paper sheets during the entire growth period (d 0–30) were used as a positive control (POS) to continually induce FPD. Cages with paper sheets during d 0–13 and without paper sheets during d 14–30 were used to examine the dynamic of FPD development and lesion wound healing (LWH). Footpad lesions were scored to grade (G) 1–5 with no lesion in G1 and most severe lesion in G5. Covering with paper sheets in POS and LWH induced 99% incidence of G3 footpads on d 13. Removing paper sheets from LWH healed footpad lesions by d 30. One representative bird, with lesions most close to pen average lesion score, was chosen to collect footpad skin samples for biomarker analysis. Total collagen protein and mRNA levels of tenascin X (TNX), type I α1 collagen (COL1A1), type III α1 collagen (COL3A1), tissue inhibitor of metalloproteinase 3 (TIMP3), and integrin α1 (ITGA1) mRNA levels were decreased (P < 0.05), while mRNA levels of tenascin C (TNC), tumor necrosis factor (TNF) α, Toll-like receptor (TLR) 4 and vascular endothelial growth factor (VEGF), IL-1β, and the ratio of MMP2 to all TIMP were increased (P < 0.03) in G3 footpads in POS and LWH compared to G1 footpads in NEG on d 14. These parameters continued to worsen with development of more severe lesions in POS. After paper sheets were removed (i.e., LWH), levels of these parameters gradually or rapidly returned to levels measured in NEG. Regression analysis indicated significant quadratic changes of these parameters to footpad lesion scores. In summary, these biomarkers were interrelated with dynamic changes of footpad lesion scores, suggesting they may be used as potential biomarkers for footpad lesion development and wound healing process. PMID:26973819

NMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1.

PubMed

Ahammer, Linda; Grutsch, Sarina; Wallner, Michael; Ferreira, Fatima; Tollinger, Martin

2017-10-01

In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 occurs as a mixture of various isoforms that possess different immunological properties despite their high sequence identities. Bet v 1.0102 (Bet v 1d), which is investigated here, is a hypoallergenic isoform of Bet v 1 and a potential candidate for allergen-specific immunotherapy. We assigned the backbone and side chain 1 H, 13 C and 15 N resonances of this protein and predicted its secondary structure. The NMR-chemical shift data indicate that Bet v 1.0102 is composed of three α-helices and a seven stranded β-sheet, in agreement with the known structure of the hyperallergenic isoform Bet v 1.0101 (Bet v 1a). Our resonance assignments create the foundation for detailed characterization of the dynamic properties of Bet v 1 isoforms by NMR relaxation measurements.

Solution 1H NMR determination of secondary structure for the three-iron form of ferredoxin from the hyperthermophilic archaeon Pyrococcus furiosus.

PubMed

Teng, Q; Zhou, Z H; Smith, E T; Busse, S C; Howard, J B; Adams, M W; La Mar, G N

1994-05-24

Two-dimensional 1H NMR data have been used to make sequence-specific assignments and define the secondary structure of the three-iron form of the oxidized ferredoxin, Fd, from the hyperthermophilic archaeon Pyrococcus furiosus, Pf. Signals for at least some protons were located for 65 of the 66 amino acids in the sequence, in spite of the paramagnetic (S = 1/2) ground state, but not all could be assigned. Unassigned and missing signals could be qualitatively correlated with the expected proximity of the protons to the paramagnetic cluster. The secondary structure was deduced from qualitative analysis of the 2D nuclear Overhauser effect, which identified two antiparallel beta-sheets, one triple-stranded including Ala1-Ser5, Val39-Glu41, and Thr62-Ala66, and one double-stranded consisting of Glu26-Asn28 and Lys32-Glu34, as well as an alpha-helix involving Glu43-Glu54. Three tight type I turns are located at residues Asp7-Thr10, Pro22-Phe25, and Asp29-Gly31. Comparison with the crystal structure of Desulfovibrio gigas, Dg, Fd (Kissinger et al., 1991) reveals a very similar folding topology, although several secondary structural elements are extended in Pf relative to Dg Fd. Thus the beta-sheet involving the two termini is expanded to include the two terminal residues and incorporates a third strand from the internal loop that is lengthened by several insertions in Pf relative to Dg Fd. The double-stranded beta-sheet in the interior of Pf Fd is lengthened slightly due to a much tighter type I turn between the two strands. The helix near the C-terminus is three residues longer in Pf than in Dg Fd, as well as being shifted toward the N-terminus. The disulfide link between the two nonligating Cys residues (Cys21 and Cys48) is conserved in Pf Fd, but the link near the C-terminus is in the middle of the long alpha-helix in Pf Fd, instead of at the N-terminus of the helix as in Dg Fd. The extensions of the beta-sheets and alpha-helix increase the number of main-chain hydrogen bonds in Pf Fd by approximately 8 relative to those in Dg Fd and likely contribute to its remarkable thermostability (it is unaffected by anaerobic incubation at 95 degrees C for 24 h).(ABSTRACT TRUNCATED AT 400 WORDS)

Sequential /sup 1/H NMR assignments and secondary structure of hen egg white lysozyme in solution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Redfield, C.; Dobson, C.M.

Assignments of /sup 1/H NMR resonances of 121 of the 129 residues of hen egg white lysozyme have been obtained by sequence-specific methods. Spin systems were identified with phase-sensitive two-dimensional (2-D) correlated spectroscopy and single and double relayed coherence transfer spectroscopy. For key types of amino acid residues, particularly alanine, threonine, valine, and glycine, complete spin systems were identified. For other residues a less complete definition of the spin system was found to be adequate for the purpose of sequential assignment. Sequence-specific assignments were achieved by phase-sensitive 2-D nuclear Overhauser enhancement spectroscopy (NOESY). Exploitation of the wide range of hydrogenmore » exchange rates found in lysozyme was a useful approach to overcoming the problem of spectral overlap. The sequential assignment was built up from 21 peptide segments ranging in length from 2 to 13 residues. The NOESY spectra were also used to provide information about the secondary structure of the protein in solution. Three helical regions and two regions of ..beta..-sheet were identified from the NOESY data; these regions are identical with those found in the X-ray structure of hen lysozyme. Slowly exchanging amides are generally correlated with hydrogen bonding identified in the X-ray structure; a number of exceptions to this general trend were, however, found. The results presented in this paper indicate that highly detailed information can be obtained from 2-D NMR spectra of a protein that is significantly larger than those studies previously.« less

Control performance of paper-based blood analysis devices through paper structure design.

PubMed

Li, Lizi; Huang, Xiaolei; Liu, Wen; Shen, Wei

2014-12-10

In this work, we investigated the influence of paper structure on the performance of paper-based analytical devices that are used for blood analysis. The question that we aimed to answer is how the fiber type (i.e., softwood and hardwood fibers) influences the fiber network structure of the paper, which affects the transport of red blood cells (RBCs) in paper. In the experimental design, we isolated the influence of fiber types on the paper structure from all other possible influencing factors by removing the fines from the pulps and not using any additives. Mercury porosimetry was employed to characterize the pore structures of the paper sheets. The results show that papers with a low basis weight that are made with short hardwood fibers have a higher porosity (i.e., void fraction) and simpler pore structures compared with papers made with long softwood fibers. RBC transport in paper carried by saline solution was investigated in two modes: lateral chromatographic elution and vertical flow-through. The results showed that the complexity of the paper's internal pore structure has a dominant influence on the transport of RBCs in paper. Hardwood fiber sheets with a low basis weight have a simple internal pore structure and allow for the easy transport of RBCs. Blood-typing sensors built with low basis weight hardwood fibers deliver high-clarity assays. Softwood fiber papers are found to have a more complex pore structure, which makes RBC transport more difficult, leading to blood-typing results of low clarity. This study provides the principle of paper sheet design for paper-based blood analysis sensors.

On the long-term memory of the Greenland Ice Sheet

NASA Astrophysics Data System (ADS)

Rogozhina, I.; Martinec, Z.; Hagedoorn, J. M.; Thomas, M.; Fleming, K.

2011-03-01

In this study, the memory of the Greenland Ice Sheet (GIS) with respect to its past states is analyzed. According to ice core reconstructions, the present-day GIS reflects former climatic conditions dating back to at least 250 thousand years before the present (kyr BP). This fact must be considered when initializing an ice sheet model. The common initialization techniques are paleoclimatic simulations driven by atmospheric forcing inferred from ice core records and steady state simulations driven by the present-day or past climatic conditions. When paleoclimatic simulations are used, the information about the past climatic conditions is partly reflected in the resulting present-day state of the GIS. However, there are several important questions that need to be clarified. First, for how long does the model remember its initial state? Second, it is generally acknowledged that, prior to 100 kyr BP, the longest Greenland ice core record (GRIP) is distorted by ice-flow irregularities. The question arises as to what extent do the uncertainties inherent in the GRIP-based forcing influence the resulting GIS? Finally, how is the modeled thermodynamic state affected by the choice of initialization technique (paleo or steady state)? To answer these questions, a series of paleoclimatic and steady state simulations is carried out. We conclude that (1) the choice of an ice-covered initial configuration shortens the initialization simulation time to 100 kyr, (2) the uncertainties in the GRIP-based forcing affect present-day modeled ice-surface topographies and temperatures only slightly, and (3) the GIS forced by present-day climatic conditions is overall warmer than that resulting from a paleoclimatic simulation.

The GLAS Standard Data Products Specification-Level 1, Version 9

NASA Technical Reports Server (NTRS)

Lee, Jeffrey E.

2013-01-01

The Geoscience Laser Altimeter System (GLAS) is the primary instrument for the ICESat (Ice, Cloud and Land Elevation Satellite) laser altimetry mission. ICESat was the benchmark Earth Observing System (EOS) mission for measuring ice sheet mass balance, cloud and aerosol heights, as well as land topography and vegetation characteristics. From 2003 to 2009, the ICESat mission provided multi-year elevation data needed to determine ice sheet mass balance as well as cloud property information, especially for stratospheric clouds common over polar areas. It also provided topography and vegetation data around the globe, in addition to the polar-specific coverage over the Greenland and Antarctic ice sheets.This document defines the Level-1 GLAS standard data products. This document addresses the data flow, interfaces, record and data formats associated with the GLAS Level 1 standard data products. GLAS Level 1 standard data products are composed of Level 1A and Level 1B data products. The term standard data products refers to those EOS instrument data that are routinely generated for public distribution. The National Snow and Ice Data Center (NSDIC) distribute these products. Each data product has a unique Product Identification code assigned by the Senior Project Scientist. GLAS Level 1A and Level 1B Data Products are composed from those Level 0 data that have been reformatted or transformed to corrected and calibrated data in physical units at the full instrument rate and resolution.

Protein structure and the sequential structure of mRNA: alpha-helix and beta-sheet signals at the nucleotide level.

PubMed

Brunak, S; Engelbrecht, J

1996-06-01

A direct comparison of experimentally determined protein structures and their corresponding protein coding mRNA sequences has been performed. We examine whether real world data support the hypothesis that clusters of rare codons correlate with the location of structural units in the resulting protein. The degeneracy of the genetic code allows for a biased selection of codons which may control the translational rate of the ribosome, and may thus in vivo have a catalyzing effect on the folding of the polypeptide chain. A complete search for GenBank nucleotide sequences coding for structural entries in the Brookhaven Protein Data Bank produced 719 protein chains with matching mRNA sequence, amino acid sequence, and secondary structure assignment. By neural network analysis, we found strong signals in mRNA sequence regions surrounding helices and sheets. These signals do not originate from the clustering of rare codons, but from the similarity of codons coding for very abundant amino acid residues at the N- and C-termini of helices and sheets. No correlation between the positioning of rare codons and the location of structural units was found. The mRNA signals were also compared with conserved nucleotide features of 16S-like ribosomal RNA sequences and related to mechanisms for maintaining the correct reading frame by the ribosome.

Measuring University students' understanding of the greenhouse effect - a comparison of multiple-choice, short answer and concept sketch assessment tools with respect to students' mental models

NASA Astrophysics Data System (ADS)

Gold, A. U.; Harris, S. E.

2013-12-01

The greenhouse effect comes up in most discussions about climate and is a key concept related to climate change. Existing studies have shown that students and adults alike lack a detailed understanding of this important concept or might hold misconceptions. We studied the effectiveness of different interventions on University-level students' understanding of the greenhouse effect. Introductory level science students were tested for their pre-knowledge of the greenhouse effect using validated multiple-choice questions, short answers and concept sketches. All students participated in a common lesson about the greenhouse effect and were then randomly assigned to one of two lab groups. One group explored an existing simulation about the greenhouse effect (PhET-lesson) and the other group worked with absorption spectra of different greenhouse gases (Data-lesson) to deepen the understanding of the greenhouse effect. All students completed the same assessment including multiple choice, short answers and concept sketches after participation in their lab lesson. 164 students completed all the assessments, 76 completed the PhET lesson and 77 completed the data lesson. 11 students missed the contrasting lesson. In this presentation we show the comparison between the multiple-choice questions, short answer questions and the concept sketches of students. We explore how well each of these assessment types represents student's knowledge. We also identify items that are indicators of the level of understanding of the greenhouse effect as measured in correspondence of student answers to an expert mental model and expert responses. Preliminary data analysis shows that student who produce concept sketch drawings that come close to expert drawings also choose correct multiple-choice answers. However, correct multiple-choice answers are not necessarily an indicator that a student produces an expert-like correlating concept sketch items. Multiple-choice questions that require detailed knowledge of the greenhouse effect (e.g. direction of re-emission of infrared energy from greenhouse gas) are significantly more likely to be answered correctly by students who also produce expert-like concept sketch items than by students who don't include this aspect in their sketch and don't answer the multiple choice questions correctly. This difference is not as apparent for less technical multiple-choice questions (e.g. type of radiation emitted by Sun). Our findings explore the formation of student's mental models throughout different interventions and how well the different assessment techniques used in this study represent the student understanding of the overall concept.

Error behaviors associated with loss of competency in Alzheimer's disease.

PubMed

Marson, D C; Annis, S M; McInturff, B; Bartolucci, A; Harrell, L E

1999-12-10

To investigate qualitative behavioral changes associated with declining medical decision-making capacity (competency) in patients with AD. Qualitative measures can yield clinical information about functional changes in neurologic disease not available through quantitative measures. Normal older controls (n = 21) and patients with mild and moderate probable AD (n = 72) were compared using a standardized competency measure and neuropsychological measures. A system of 16 qualitative error scores representing conceptual domains of language, executive dysfunction, affective dysfunction, and compensatory responses was used to analyze errors produced on the competency measure. Patterns of errors were examined across groups. Relationships between error behaviors and competency performance were determined, and neurocognitive correlates of specific error behaviors were identified. AD patients demonstrated more miscomprehension, factual confusion, intrusions, incoherent responses, nonresponsive answers, loss of task, and delegation than controls. Errors in the executive domain (loss of task, nonresponsive answer, and loss of detachment) were key predictors of declining competency performance by AD patients. Neuropsychological analyses in the AD group generally confirmed the conceptual domain assignments of the qualitative scores. Loss of task, nonresponsive answers, and loss of detachment were key behavioral changes associated with declining competency of AD patients and with neurocognitive measures of executive dysfunction. These findings support the growing linkage between executive dysfunction and competency loss.

Data-Driven Design: Learning from Student Experiences and Behaviors

NASA Astrophysics Data System (ADS)

Horodyskyj, L.; Mead, C.; Buxner, S.; Semken, S. C.; Anbar, A. D.

2015-12-01

Good instructors know that lessons and courses change over time. Limitations in time and data often prevent instructors from making changes that will most benefit their students. For example, in traditional in-person classrooms an instructor may only have access to the final product of a student's thought processes (such as a term paper, homework assignment, or exam). The thought processes that lead to a given answer are opaque to the instructor, making future modifications to course content an exercise in trial-and-error and instinct. Modern online intelligent tutoring systems can provide insight into a student's behavior, providing transparency to a previously opaque process and providing the instructor with better information for course modification. Habitable Worlds is an introductory level online-only astrobiology lab course that has been offered at Arizona State University since Fall 2011. The course is built and offered through an intelligent tutoring system, Smart Sparrow's Adaptive eLearning Platform, which provides in-depth analytics that allow the instructor to investigate detailed student behavior, from time spent on question to number of attempts to patterns of answers. We will detail the process we employ of informed modification of course content, including time and trial comparisons between semesters, analysis of submitted answers, analysis of alternative learning pathways taken, and A/B testing.

Characterizing the Secondary Protein Structure of Black Widow Dragline Silk Using Solid-State NMR & X-ray Diffraction

PubMed Central

Jenkins, Janelle E.; Sampath, Sujatha; Butler, Emily; Kim, Jihyun; Henning, Robert W.; Holland, Gregory P.; Yarger, Jeffery L.

2013-01-01

This study provides a detailed secondary structural characterization of major ampullate dragline silk from Latrodectus hesperus (black widow) spiders. X-ray diffraction results show that the structure of black widow major ampullate silk fibers is comprised of stacked β-sheet nanocrystallites oriented parallel to the fiber axis and an amorphous region with oriented (anisotropic) and isotropic components. The combination of two-dimensional (2D) 13C-13C through-space and through-bond solid-state NMR experiments provide chemical shifts that are used to determine detailed information about amino acid motif secondary structure in black widow spider dragline silk. Individual amino acids are incorporated into different repetitive motifs that make up the majority of this protein-based biopolymer. From the solid-state NMR measurements, we assign distinct secondary conformations to each repetitive amino acid motif and hence to the amino acids that make up the motifs. Specifically, alanine is incorporated in β-sheet (poly(Alan) and poly(Gly-Ala)), 31-helix (poly(Gly-Gly-Xaa), and α-helix (poly(Gln-Gln-Ala-Tyr)) components. Glycine is determined to be in β-sheet (poly(Gly-Ala)) and 31-helical (poly(Gly-Gly-Xaa)) regions, while serine is present in β-sheet (poly(Gly-Ala-Ser)), 31-helix (poly(Gly-Gly-Ser)), and β-turn (poly(Gly-Pro-Ser)) structures. These various motif-specific secondary structural elements are quantitatively correlated to the primary amino acid sequence of major ampullate spidroin 1 and 2 (MaSp1 and MaSp2) and are shown to form a self-consistent model for black widow dragline silk. PMID:24024617

Effectiveness of Placebo Therapy for Maintaining Masking in a Clinical Trial of Vergence/Accommodative Therapy

PubMed Central

Kulp, Marjean; Mitchell, G. Lynn; Borsting, Eric; Scheiman, Mitchell; Cotter, Susan; Rouse, Michael; Tamkins, Susanna; Mohney, Brian G.; Toole, Andrew; Reuter, Kathleen

2009-01-01

Purpose To evaluate the effectiveness of the Convergence Insufficiency Treatment Trial (CITT) placebo therapy program in maintaining masking of patients randomized to the office-based treatment arms, determine whether demographic variables affect masking, and determine whether perception of assigned treatment group was associated with treatment outcome or adherence to treatment. Methods Patients (n = 221, ages, 9–17 years) were randomized to one of four treatment groups, two of which were office-based and masked to treatment (n = 114). The placebo therapy program was designed to appear to be real vergence/accommodative therapy, without stimulating vergence, accommodation, or fine saccades (beyond levels of daily visual activities). After treatment, patients in the office-based groups were asked whether they thought they had received real or placebo therapy and how confident they were in their answers. Results Ninety-three percent of patients assigned to real therapy and 85% assigned to placebo therapy thought they were in the real therapy group (P = 0.17). No significant differences were found between the two groups in adherence to the therapy (P ≥ 0.22 for all comparisons). The percentage of patients who thought they were assigned to real therapy did not differ by age, sex, race, or ethnicity (P > 0.30 for all comparisons). No association was found between patients' perception of group assignment and symptoms or signs at outcome (P ≥ 0.38 for all comparisons). Conclusions The CITT placebo therapy program was effective in maintaining patient masking in this study and therefore may have potential for use in future clinical trials using vergence/accommodative therapy. Masking was not affected by demographic variables. Perception of group assignment was not related to symptoms or signs at outcome (ClinicalTrials.gov number, NCT00338611). PMID:19151384

Dynamics of the Oligocene Southern Ocean: dinocysts as surface paleoceanographic tracers

NASA Astrophysics Data System (ADS)

Bijl, Peter; Houben, Alexander; Brinkhuis, Henk; Sangiorgi, Francesca

2015-04-01

The Oligocene Epoch (33.9-23 Ma) is the time interval in the Cenozoic that saw the establishment of a continental-scale Antarctic ice-sheet. There remains a controversy about whether this early episode of a glaciated Antarctica was stable, or whether dynamic ice conditions prevailed. Most of this controversy persists due to the absence of chronostratigraphically well-dated sedimentary archives from close to the east Antarctic ice sheet, which has recorded a direct signal of glacial dynamics. Another major question is how the Oligocene Southern Ocean responded to the glaciation and subsequent evolution of the ice sheet, as the Southern ocean is a major player in global ocean circulation. Numerical modelling studies suggest that alongside the buildup of continental ice on Antarctica, first sea-ice conditions may have started along the East Antarctic Margin, but this conclusion lacks support from field evidence. Other numerical models predict that hysteresis effects within the ice sheet will make a continental-size Antarctic ice sheet rather insensitive to warming. In contrast, deep-water benthic foraminiferal oxygen isotope records across the Oligocene suggest dramatic waxing and waning of Antarctic ice sheets. This paradox is as yet not solved Integrated Ocean Drilling Expedition 318 drilled the Antarctic Margin in 2010, and recovered sediments from the early phase of Antarctic glaciation. With this record, we can now evaluate the robustness of the results of the numerical models and the oceanographic changes with field data. Sediments recovered from Site U1356 yield a thick and relatively complete (albeit compromised by core gaps) Oligocene succession both of which are chrono-stratigraphically well-calibrated with use of nannoplankton- dinocyst- and magnetostratigraphy. Notably, this record yields well-preserved dinoflagellate cysts (dinocysts), which we can use to investigate surface-water condition changes across the Eocene-Oligocene to provide answers to these outstanding questions. In the earliest Oligocene, just after the onset of Antarctic glaciation, we document the installation of dinoflagellate cyst assemblages that bear remarkable similarity with those of the present-day Southern Ocean. We interpret this as a regime-shift in plankton communities in response to the installation of the seasonally highly productive sea-ice ecosystem. Throughout the Oligocene the pattern of eutrophic, influence continues, but the sea-ice-related cysts disappear about 1.5 Myrs following their appearance, consistent with a major rebound phase of the deep-sea oxygen isotopes. Surprisingly, throughout the Oligocene, the heterotrophic, sea-ice dinocysts are accompanied by episodically even abundant oligotrophic species. These results suggest fundamental differences in the physical oceanographic condition of the ACC compared to present-day and may explain why the Oligocene icehouse world is as dynamic as suggested by deep-water benthic foraminiferal oxygen isotopes. The direct field evidence definitely confirm a dynamic Oligocene icehouse, and imply that some fundamental physics or feedbacks are missing in the ice sheet models that predict a stable ice sheet.

Marine Corps Joint Assignment Model under Title 4 of the Goldwater- Nichols Act of 1986

DTIC Science & Technology

1989-09-01

gressional concern for continuity. An officer with a COS MOS who has served a two year JDA tour as a JSO nominee has an increased chance of being...completed JDA tours as JSO nominees. The overall concern of Title IV is the requirement for quality officers to fll JDA billets. Title IV mandates the...answered concerning changes in 4 promotion rates and in the mix of majors, lieutenant colonels and colonels to be used to 1ill iDA billets. However, the

Recent THEMIS and Coordinated GBO Measurements of Substorm Expansion Onset: Do We Finally Have an Answer?

NASA Technical Reports Server (NTRS)

Kepko, L.

2011-01-01

For nearly 30 years an often-times heated debate has engaged the substorm community: Do substorms begin with the formation of a new reconnection site in the midtail plasma sheet (the Near-Earth Neutral Line model) or do they begin near the transition region between stretched tail and dipolar field lines (the Current Disruption model). The THEMIS mission, with a coordinated suite of five in-situ spacecraft and ground observatories, has greatly extended our understanding of how substorms initiate and evolve. But have the new data resolved the fundamental question? In this talk I review the last few year's of sub storm research, with an emphasis of how the THEMIS data have revolutionized our understanding.

Sojourner Rover View of Cloddy Deposits near Pooh Bear

NASA Technical Reports Server (NTRS)

1997-01-01

Sojourner's observations in the Ares region on Mars raise and answer questions about the origins of the rocks and other deposits found there. Deposits are not the same everywhere. Bright, fine-grained drifts (right center) are abundant as thin (less than a few centimeters), discontinuous ridged sheets and wind tails that overlie cloddy deposits of dust, clods, and tiny (less than 1 cm) rocks.

NOTE: original caption as published in Science Magazine

Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech).

Synthesis, crystal structure, and vibrational spectroscopic and UV-visible studies of Cs{sub 2}MnP{sub 2}O{sub 7}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaoua, Saida; Krimi, Saida; Pechev, Stanislav

2013-02-15

A new member of the A{sub 2}MP{sub 2}O{sub 7} diphosphate family, Cs{sub 2}MnP{sub 2}O{sub 7}, has been synthesized and structurally characterized. The crystal structure was determined by single crystal X-Ray diffraction. Cs{sub 2}MnP{sub 2}O{sub 7} crystallizes in the orthorhombic system, space group Pnma ( Music-Sharp-Sign 62), with the unit cell parameters a=16.3398(3), b=5.3872(1), c=9.8872(2) A, Z=4 and V=870.33(3) A{sup 3}. The structure parameters were refined to a final R{sub 1}/wR{sub 2}=0.0194/0.0441 for 1650 observed reflections. The 2D framework of Cs{sub 2}MnP{sub 2}O{sub 7} structure consists of P{sub 2}O{sub 7} and MnO{sub 5} units. The corner-shared MnO{sub 5} and P{sub 2}O{submore » 7} units are alternately arranged along the b axis to form [(MnO)P{sub 2}O{sub 7}]{sub {infinity}} chains. These chains are interconnected by an oxygen atom to form sheets parallel to the (b, c) plane. The cesium atoms are located between the sheets in 9- and 10-fold coordinated sites. The infrared and Raman vibrational spectra have been investigated. A factor group analysis leads to the determination of internal modes of (P{sub 2}O{sub 7}) groups. UV-visible spectrum consists of weak bands, between 340 and 700 nm, assigned to the forbidden d-d transitions of Mn{sup 2+} ion, and of a strong band around 250 nm, attributed to the O--Mn charge transfer. - Graphical abstract: Structure of Cs{sub 2}MnP{sub 2}O{sub 7}: The 2D structure of Cs{sub 2}MnP{sub 2}O{sub 7} is built from P{sub 2}O{sub 7} diphosphate groups and MnO{sub 5} square pyramids which share corners and form [(MnO)P{sub 2}O{sub 7}]{sub {infinity}} chains along b axis. These chains are interconnected by an oxygen atom to form wavy (MnP{sub 2}O{sub 7}){sup 2-} sheets parallel to the (b, c) plane. The cesium ions are located between these sheets in the inter-layers space, in zigzag positions. Highlights: Black-Right-Pointing-Pointer A new diphosphate, Cs{sub 2}MnP{sub 2}O{sub 7}, has been synthesized and structurally characterized. Black-Right-Pointing-Pointer The structure consists of a 2D framework built up from (MnP{sub 2}O{sub 7}) sheets. Black-Right-Pointing-Pointer The sheets consist of [(MnO)P{sub 2}O{sub 7}]{sub {infinity}} chains formed by P{sub 2}O{sub 7} units and MnO{sub 5} square pyramids. Black-Right-Pointing-Pointer A factor group analysis leads to the determination of internal modes of (P{sub 2}O{sub 7}) groups. Black-Right-Pointing-Pointer UV-visible spectrum consists bands assigned to d-d transitions of Mn{sup 2+} ion and to O--Mn CT.« less

Documentation of Gender Identity in an Adolescent and Young Adult Clinic.

PubMed

Vance, Stanley R; Mesheriakova, Veronika V

2017-03-01

To determine if changing electronic health record (EHR) note templates can increase documentation of gender identity in an adolescent and young adult clinic. A two-step gender question was added to EHR note templates for physicals in February 2016. A retrospective chart review was performed 3 months before and after this addition. The primary measure was whether answers to the two-step question were documented. Gender identity/birth-assigned sex discordance, age, and use of the appropriate note template post-template change were also measured. One hundred twenty-five pretemplate change and 106 post-template change physicals were reviewed with an inter-rater reliability of 97%. Documentation of answers to the two-step gender identity question increased from 11% to 84% (p < .001). This study suggests that incorporating a standardized question into EHR note templates is effective at improving the documentation of gender identity in youth presenting for annual physicals. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

A pharmacy practice laboratory exercise to apply biochemistry concepts.

PubMed

Harrold, Marc W; McFalls, Marsha A

2010-10-11

To develop exercises that allow pharmacy students to apply foundational knowledge discussed in a first-professional year (P1) biochemistry course to specific disease states and patient scenarios. A pharmacy practice laboratory exercise was developed to accompany a lecture sequence pertaining to purine biosynthesis and degradation. The assignment required students to fill a prescription, provide patient counseling tips, and answer questions pertaining to the disease state, the underlying biochemical problem, and the prescribed medication. Students were graded on the accuracy with which they filled the prescription, provided patient counseling, and answered the questions provided. Overall, students displayed mastery in all of these areas. Additionally, students completed a course survey on which they rated this exercise favorably, noting that it helped them to integrate basic science concepts and pharmacy practice. A laboratory exercise provided an opportunity for P1 students to apply foundational pharmacy knowledge to a patient case and can serve as a template for the design of additional exercises.

Social media and the classroom?

NASA Astrophysics Data System (ADS)

2015-02-01

Many years ago, I learned (through eavesdropping on a conversation during lab) that my students had set up their own Facebook group. They told me they were using it to help each other with homework assignments. This year, my daughter took physics at a university. She and her friends were struggling a bit with the online quizzes. I suggested that she set up a Facebook community and add me as a member. I would answer questions and help the group study. My daughter's group used Facebook to get answers to specific questions from the quizzes. They often ended up helping each other because the questions were posed quite late in the evening. Questions ranged from exact copies of the original queries to "Does anyone know what equation to use for this?" I began to think that, although their grades were improving on the quizzes, they were not gaining any content knowledge. To combat this, I made and posted a few short video clips reteaching the content.

An interactive online approach to small-group student presentations and discussions.

PubMed

Thor, Der; Xiao, Nan; Zheng, Meixun; Ma, Ruidan; Yu, Xiao Xi

2017-12-01

Student presentations had been widely implemented across content areas, including health sciences education. However, due to various limitations, small-group student presentations in the classroom may not reach their full potential for student learning. To address challenges with presentations in the classroom, we redesigned the assignment by having students present and discuss online using VoiceThread, a cloud-based presentation and discussion tool. First-year students pursuing a Doctor of Dental Surgery degree were assigned into small groups to present physiology content and to discuss that content online. This assignment was similar to traditional student classroom presentations, with the exception that the entire assignment was conducted online. The primary purpose of this exploratory study was to investigate the impact of the online format on the discussion quality. Another purpose of the study was to examine students' perceptions of using VoiceThread for presenting and learning, as well as the online interactions between the presenter and audience. Students posted a higher number of questions and comments than required by the assignment. The questions from students were also higher level questions, and the answers to these questions were more thorough compared with what we had previously observed in classroom presentations. The survey results showed that students preferred using VoiceThread for presenting, learning from other presentations, and discussing presentation content over performing this process in the classroom. Preliminary findings suggested that having dental students make presentations and hold discussions online might help address the challenges of student presentations in the classroom. Copyright © 2017 the American Physiological Society.

Developing learning community model with soft skill integration for the building engineering apprenticeship programme in vocational high school

NASA Astrophysics Data System (ADS)

Sutrisno, Dardiri, Ahmad; Sugandi, R. Machmud

2017-09-01

This study aimed to address the procedure, effectiveness, and problems in the implementation of learning model for Building Engineering Apprenticeship Training Programme. This study was carried out through survey method and experiment. The data were collected using questionnaire, test, and assessment sheet. The collected data were examined through description, t-test, and covariance analysis. The results of the study showed that (1) the model's procedure covered preparation course, readiness assessment, assignment distribution, handing over students to apprenticeship instructors, task completion, assisting, field assessment, report writing, and follow-up examination, (2) the Learning Community model could significantly improve students' active learning, but not improve students' hard skills and soft skills, and (3) the problems emerging in the implementation of the model were (1) students' difficulties in finding apprenticeship places and qualified instructors, and asking for relevant tasks, (2) teachers' difficulties in determining relevant tasks and monitoring students, and (3) apprenticeship instructors' difficulties in assigning, monitoring, and assessing students.

Contact replacement for NMR resonance assignment.

PubMed

Xiong, Fei; Pandurangan, Gopal; Bailey-Kellogg, Chris

2008-07-01

Complementing its traditional role in structural studies of proteins, nuclear magnetic resonance (NMR) spectroscopy is playing an increasingly important role in functional studies. NMR dynamics experiments characterize motions involved in target recognition, ligand binding, etc., while NMR chemical shift perturbation experiments identify and localize protein-protein and protein-ligand interactions. The key bottleneck in these studies is to determine the backbone resonance assignment, which allows spectral peaks to be mapped to specific atoms. This article develops a novel approach to address that bottleneck, exploiting an available X-ray structure or homology model to assign the entire backbone from a set of relatively fast and cheap NMR experiments. We formulate contact replacement for resonance assignment as the problem of computing correspondences between a contact graph representing the structure and an NMR graph representing the data; the NMR graph is a significantly corrupted, ambiguous version of the contact graph. We first show that by combining connectivity and amino acid type information, and exploiting the random structure of the noise, one can provably determine unique correspondences in polynomial time with high probability, even in the presence of significant noise (a constant number of noisy edges per vertex). We then detail an efficient randomized algorithm and show that, over a variety of experimental and synthetic datasets, it is robust to typical levels of structural variation (1-2 AA), noise (250-600%) and missings (10-40%). Our algorithm achieves very good overall assignment accuracy, above 80% in alpha-helices, 70% in beta-sheets and 60% in loop regions. Our contact replacement algorithm is implemented in platform-independent Python code. The software can be freely obtained for academic use by request from the authors.

1H, 13C, and 15N backbone assignment and secondary structure of the receptor-binding domain of vascular endothelial growth factor.

PubMed Central

Fairbrother, W. J.; Champe, M. A.; Christinger, H. W.; Keyt, B. A.; Starovasnik, M. A.

1997-01-01

Nearly complete sequence-specific 1H, 13C, and 15N resonance assignments are reported for the backbone atoms of the receptor-binding domain of vascular endothelial growth factor (VEGF), a 23-kDa homodimeric protein that is a major regulator of both normal and pathological angiogenesis. The assignment strategy relied on the use of seven 3D triple-resonance experiments [HN(CO)CA, HNCA, HNCO, (HCA)CONH, HN(COCA)HA, HN(CA)HA, and CBCA-(CO)NH] and a 3D 15N-TOCSY-HSQC experiment recorded on a 0.5 mM (12 mg/mL) sample at 500 MHz, pH 7.0, 45 degrees C. Under these conditions, 15N relaxation data show that the protein has a rotational correlation time of 15.0 ns. Despite this unusually long correlation time, assignments were obtained for 94 of the 99 residues; 8 residues lack amide 1H and 15N assignments, presumably due to rapid exchange of the amide 1H with solvent under the experimental conditions used. The secondary structure of the protein was deduced from the chemical shift indices of the 1H alpha, 13C alpha, 13C beta, and 13CO nuclei, and from analysis of backbone NOEs observed in a 3D 15N-NOESY-HSQC spectrum. Two helices and a significant amount of beta-sheet structure were identified, in general agreement with the secondary structure found in a recently determined crystal structure of a similar VEGF construct [Muller YA et al., 1997, Proc Natl Acad Sci USA 94:7192-7197]. PMID:9336848

Two-dimensional sup 1 H nuclear magnetic resonance study of AaH IT, an anti-insect toxin from the scorpion Androctonus australis Hector. Sequential resonance assignments and folding of the polypeptide chain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Darbon, H.; Weber, C.; Braun, W.

1991-02-19

Sequence-specific nuclear magnetic resonance assignments for the polypeptide backbone and for most of the amino acid side-chain protons, as well as the general folding of AaH IT, are described. AaH IT is a neurotoxin purified from the venom of the scorpion Androctonus australis Hector and is specifically active on the insect nervous system. The secondary structure and the hydrogen-bonding patterns in the regular secondary structure elements are deduced from nuclear Overhauser effects and the sequence locations of the slowly exchanging amide protons. The backbone folding is determined by distance geometry calculations with the DISMAN program. The regular secondary structure includesmore » two and a half turns of {alpha}-helix running from residues 21 to 30 and a three-stranded antiparallel {beta}-sheet including peptides 3-5, 34-38, and 41-46. Two tight turns are present, one connecting the end of the {alpha}-helix to an external strand of the {beta}-sheet, i.e., turn 31-34, and another connecting this same strand to the central one, i.e., turn 38-41. The differences in the specificity of these related proteins, which are able to discriminate between mammalian and insect voltage-dependent sodium channels of excitable tissues, are most probably brought about by the position of the C-terminal peptide with regard to a hydrophobic surface common to all scorpion toxins examined thus far. Thus, the interaction of a given scorpion toxin with its receptor might well be governed by the presence of this solvent-exposed hydrophobic surface, whereas adjacent areas modulate the specificity of the interaction.« less

Antarctic subglacial groundwater: measurement concept and potential influence on ice flow

NASA Astrophysics Data System (ADS)

Kulessa, Bernd; Siegert, Martin; Bougamont, Marion; Christoffersen, Poul; Key, Kerry; Andersen, Kristoffer; Booth, Adam; Smith, Andrew

2017-04-01

Is groundwater abundant in Antarctica and does it modulate ice flow? Answering this question matters because ice streams flow by gliding over a wet substrate of till. Water fed to ice-stream beds thus influences ice-sheet dynamics and, potentially, sea-level rise. It is recognised that both till and the sedimentary basins from which it originates are porous and could host a reservoir of mobile groundwater that interacts with the subglacial interfacial system. According to recent numerical modelling up to half of all water available for basal lubrication, and time lags between hydrological forcing and ice-sheet response as long as millennia, may have been overlooked in models of ice flow. Here, we review evidence in support of Antarctic groundwater and propose how it can be measured to ascertain the extent to which it modulates ice flow. We present new seismoelectric soundings of subglacial till, and new magnetotelluric and transient electromagnetic forward models of subglacial groundwater reservoirs. We demonstrate that multi-facetted and integrated geophysical datasets can detect, delineate and quantify the groundwater contents of subglacial sedimentary basins and, potentially, monitor groundwater exchange rates between subglacial till layers. We thus describe a new area of glaciological investigation and how it should progress in future.

Mini-Journals: Incorporating Inquiry, Quantitative Skills and Writing into Homework Assignments for Geochemistry and Planetary Science

NASA Astrophysics Data System (ADS)

Whittington, A. G.; Speck, A.; Witzig, S.

2011-12-01

As part of an NSF-funded project, "CUES: Connecting Undergraduates to the Enterprise of Science," new inquiry-based homework materials were developed for two upper-level classes at the University of Missouri: Geochemistry (required for Geology majors, fulfills the computing requirement by having 50% of the grade come from five spreadsheet-based homework assignments), and Solar System Science (open to seniors and graduate students, co-taught and cross-listed between Geology and Physics & Astronomy). Inquiry involves activities where the learner engages in scientifically oriented questions, gives priority to evidence in responding to questions, formulates explanations from evidence, connects explanations to scientific knowledge, and communicates and justifies explanations. We engage students in inquiry-based learning by presenting homework exercises as "mini-journal" articles that follow the format of a scientific journal article, including a title, authors, abstract, introduction, methods, results, discussion and citations to peer-reviewed literature. The mini-journal provides a scaffold and serves as a springboard for students to develop and carry out their own follow-up investigation. They then present their findings in the form of their own mini-journal. Mini-journals replace traditional homework problem sets with a format that more directly reflects and encourages scientific practice. Students are engaged in inquiry-based homework which encompass doing, thinking, and communicating, while the mini-journal allows the instructor to contain lines of inquiry within the limits posed by available resources. In the examples we present, research is conducted via spreadsheet modeling, where the students develop their own spreadsheets. Example assignments from Geochemistry include "Trace Element Partitioning During Mantle Melting and MORB Crystallization" and "Isotopic Investigations of Crustal Evolution in the Midcontinent US". The key differences between the old and new formats include (i) active participation of the students in defining the question/problem that they will pursue, within well-defined boundaries, (ii) open-ended nature of the inquiry, so that students need to recognize when they have enough information to answer their question, (iii) extensive spreadsheet manipulation and presentation of results in graphical and tabular formats, and (iv) a written discussion of their findings. Grading is weighted more towards how the problem was addressed, and how findings are presented and interpreted, and less on actual numerical answers. Survey responses from students indicate that they experience discomfort on being presented with an open-ended assignment, but like the freedom to define their own problem. Students also recognize that reading, writing and critical thinking skills employed in the minijournal format increase their understanding of content. The combination of calculation and writing components make these assignments particularly useful for classes designated as "computer-based", and/or "writing intensive" (or similar designations).

GeoMapApp Learning Activities: Grab-and-go inquiry-based geoscience activities that bring cutting-edge technology to the classroom

NASA Astrophysics Data System (ADS)

Goodwillie, A. M.; Kluge, S.

2011-12-01

NSF-funded GeoMapApp Learning Activities (http://serc.carleton.edu/geomapapp) provide self-contained learning opportunities that are centred around the principles of guided inquiry. The activities allow students to interact with and analyse research-quality geoscience data to explore and enhance student understanding of underlying geoscience content and concepts. Each activity offers ready-to-use step-by-step student instructions and answer sheets that can be downloaded from the web page. Also provided are annotated teacher versions of the worksheets that include teaching tips, additional content and suggestions for further work. Downloadable pre- and post- quizzes tied to each activity help educators gauge the learning progression of their students. Short multimedia tutorials and details on content alignment with state and national teaching standards round out the package of material that comprises each "grab-and-go" activity. GeoMapApp Learning Activities expose students to content and concepts typically found at the community college, high school and introductory undergraduate levels. The activities are based upon GeoMapApp (http://www.geomapapp.org), a free, easy-to-use map-based data exploration and visualisation tool that allows students to access a wide range of geoscience data sets in a virtual lab-like environment. Activities that have so far been created under this project include student exploration of seafloor spreading rates, a study of mass wasting as revealed through geomorphological evidence, and an analysis of plate motion and hotspot traces. The step-by-step instructions and guided inquiry approach lead students through each activity, thus reducing the need for teacher intervention whilst also boosting the time that students can spend on productive exploration and learning. The activities can be used, for example, in a classroom lab with the educator present and as self-paced assignments in an out-of-class setting. GeoMapApp Learning Activities are hosted on the SERC-Carleton web site.

[Home visits for social withdrawal cases in community mental health and child welfare services].

PubMed

Kondo, Naoji; Sakai, Motohiro; Ishikawa, Shin-ichi; Niimuras, Junko; Tanoue, Michika

2008-01-01

Home visits are one of the intervention and assistance methods anticipated to be useful in cases of social withdrawal. This study aims at investigating the current status of home visits that are carried out in the regional mental health and child welfare sectors, targeting socially withdrawn adolescents, and at examining the efficacy of this method. We conducted a survey using questionnaires targeting 59 institutions, such as public health centers, health and welfare offices, and child guidance centers, and found that home visits were carried out by public health nurses and child welfare personnel in about 20% of the adolescent social withdrawal cases. Answers to the question sheets were obtained for 54 cases, and investigation revealed that some form of improvement was seen as a result of these visits in 22 cases, or 40.7%. Typical answers included: "the visit encouraged the adolescent to go to a medical institution and/or a consultation agency for examination or consultation," and the "incidence of domestic violence by the adolescent declined." The survey also revealed that 19 of the social withdrawal cases, or 35.2%, inflicted acts of violence on family members; however, 8 cases, or 42.1% showed the improvement of violence through home visits.

The Pleistocene evolution of the East Antarctic Ice Sheet in the Prydz bay region: Stable isotopic evidence from ODP Site 1167

USGS Publications Warehouse

Theissen, K.M.; Dunbar, R.B.; Cooper, A. K.; Mucciarone, D.A.; Hoffmann, D.

2003-01-01

Ocean Drilling Program Leg 188, Prydz Bay, East Antarctica is part of a larger initiative to explore the Cenozoic history of the Antarctic Ice Sheet through direct drilling and sampling of the continental margins. In this paper, we present stable isotopic results from Ocean Drilling Program (ODP) Site 1167 located on the Prydz Channel Trough Mouth Fan (TMF), the first Antarctic TMF to be drilled. The foraminifer-based ??18O record is interpreted along with sedimentary and downhole logging evidence to reconstruct the Quaternary glacial history of Prydz Bay and the adjacent Lambert Glacier Amery Ice Shelf System (LGAISS). We report an electron spin resonance age date of 36. 9 ?? 3.3 ka at 0.45 m below sea floor and correlate suspected glacial-interglacial cycles with the global isotopic stratigraphy to improve the chronology for Site 1167. The ??18O record based on planktonic (Neogloboquadrina pachyderma (s.)) and limited benthic results (Globocassidulina crassa), indicates a trend of ice sheet expansion that was interrupted by a period of reduced ice volume and possibly warmer conditions during the early-mid-Pleistocene (0.9-1.38 Ma). An increase in ?? 18O values after ??? 900 ka appears to coincide with the mid-Pleistocene climate transition and the expansion of the northern hemisphere ice sheet. The ??18O record in the upper 50 m of the stratigraphic section indicates as few as three glacial-interglacial cycles, tentatively assigned as marine isotopic stages (MIS) 16-21, are preserved since the Brunhes/Matuyama paleomagnetic reversal (780 ka). This suggests that there is a large unconformity near the top of the section and/or that there may have been few extreme advances of the ice sheet since the mid-Pleistocene climate transition resulting in lowered sedimentation rates on the Prydz Channel TMF. The stable isotopic record from Site 1167 is one of the few available from the area south of the Antarctic Polar Front that has been linked with the global isotopic stratigraphy. Our results suggest the potential for the recovery of useful stable isotopic records in other TMFs. ?? 2003 Elsevier B.V. All rights reserved.

Violations of information structure: an electrophysiological study of answers to wh-questions.

PubMed

Cowles, H W; Kluender, Robert; Kutas, Marta; Polinsky, Maria

2007-09-01

This study investigates brain responses to violations of information structure in wh-question-answer pairs, with particular emphasis on violations of focus assignment in it-clefts (It was the queen that silenced the banker). Two types of ERP responses in answers to wh-questions were found. First, all words in the focus-marking (cleft) position elicited a large positivity (P3b) characteristic of sentence-final constituents, as did the final words of these sentences, which suggests that focused elements may trigger integration effects like those seen at sentence end. Second, the focusing of an inappropriate referent elicited a smaller, N400-like effect. The results show that comprehenders actively use structural focus cues and discourse-level restrictions during online sentence processing. These results, based on visual stimuli, were different from the brain response to auditory focus violations indicated by pitch-accent [Hruska, C., Steinhauer, K., Alter, K., & Steube, A. (2000). ERP effects of sentence accents and violations of the information structure. In Poster presented at the 13th annual CUNY conference on human sentence processing, San Diego, CA.], but similar to brain responses to newly introduced discourse referents [Bornkessel, I., Schlesewsky, M., & Friederici, A. (2003). Contextual information modulated initial processes of syntactic integration: the role of inter- versus intrasentential predictions. Journal of Experimental Psychology: Learning, Memory and Cognition, 29, 871-882.].

[Are patients able to bear their share of responsibility?].

PubMed

Schuldzinski, Wolfgang

2012-01-01

To answer this question we first need to clarify the term "responsibility". Based on the different meanings of this term, it will be outlined how the expectations of different participants towards the group of patients lead to different demands being placed on their behaviour. Using examples of the interaction between patients and participants of the health care system these different role assignments will be reviewed with a view to their implementation. Subsequently the author derives conditions that need to be met in order to enable patients to act responsibly. Copyright © 2012. Published by Elsevier GmbH.

Teaching graphics in technical communication classes

NASA Technical Reports Server (NTRS)

Spurgeon, K. C.

1981-01-01

Graphic aids convey and clarify information more efficiently and accurately than words alone therefore, most technical writing includes the use of graphics. Ways of accumulating and presenting graphics illustrations on a shoestring budget are suggested. These include collecting graphics from companies, annual reports and laminating them for workshop use or putting them on a flip chart for classroom presentation, creating overhead transparencies to demonstrate different levels of effectiveness of graphic aids, and bringing in grahic artists for question/answer periods or in class workshops. Also included are an extensive handout as an introduction to graphics, sample assignments, and a selected and annotated bibliography.

Single-tier city logistics model for single product

NASA Astrophysics Data System (ADS)

Saragih, N. I.; Nur Bahagia, S.; Suprayogi; Syabri, I.

2017-11-01

This research develops single-tier city logistics model which consists of suppliers, UCCs, and retailers. The problem that will be answered in this research is how to determine the location of UCCs, to allocate retailers to opened UCCs, to assign suppliers to opened UCCs, to control inventory in the three entities involved, and to determine the route of the vehicles from opened UCCs to retailers. This model has never been developed before. All the decisions will be simultaneously optimized. Characteristic of the demand is probabilistic following a normal distribution, and the number of product is single.

Value of audio-enhanced handheld computers over paper surveys with adolescents.

PubMed

Trapl, Erika S; Taylor, H Gerry; Colabianchi, Natalie; Litaker, David; Borawski, Elaine A

2013-01-01

To examine the impact of 3 data collection modes on the number of questions answered, data quality, and student preference. 275 urban seventh-grade students were recruited and randomly assigned to complete a paper survey (SAQ), PDA survey (PDA), or PDA survey with audio (APDA). Students completed a paper debriefing survey. APDA respondents completed significantly more questions compared to SAQ and PDA. PDA and APDA had significantly less missing data than did SAQ. No differences were found for student evaluation. Strong benefits may be gained by the use of APDA for adolescent school-based data collection.

Nuclear Data Sheets for A=243

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nesaraja, Caroline D; McCutchan, Elizabeth A.

2014-09-30

We present available information pertaining to the nuclear structure of all nuclei with mass numbers A=243. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 ( 243Np, 243Pu, 243Am, 243Cm, 243Bk, and 243Cf), 2011Me01 ( 243Es), and 2013Th02 ( 243Fm).

"The Chemicals Project": Connecting General Chemistry to Students' Lives

NASA Astrophysics Data System (ADS)

Stout, Roland

2000-10-01

"The Chemicals Project" described here strives to bring freshman chemistry alive for students by emphasizing its connection to the real world and to their own lives and experiences. Its major assignments deal with chemical phobias, recognizing the chemicals found in everyday life and chemical hazards (using Material Data Safety Sheets). The project is described in a cooperative learning format, employs portfolio grading, and includes a significant writing component. Ways of linking this project with the course lecture and student evaluations of the project are described. The bottom line: pre- and post-testing shows that it works. The Chemicals Project brings chemistry alive for students.

Country Contributions to Climate Change

NASA Astrophysics Data System (ADS)

Schuenemann, K. C.

2016-12-01

An assignment called "Country Contributions to Climate Change" is used in an introductory Global Climate Change course and answers the question, "Who is responsible for climate change?" This assignment is used about a third of the way into the course, which fulfills a science requirement, but also a Global Diversity requirement within the university. The assignment involves taking a trip to the computer lab to learn how to create graphs in Excel. Two graphs are created, the Keeling Curve, and a graph on total carbon emissions by country since 1900. Students are given data for a few key countries, then are sent to the Carbon Dioxide Information Analysis Center (CDIAC) website to find data on their assigned country. Students create a graph to compare emissions over time from each of these countries. Using this data and the data from the CDIAC, students are asked to draw conclusions about which country is the largest emitter, then on a per capita basis, which people are the largest emitters. Later in the semester they will calculate their own carbon footprint and compare to these numbers. Finally, students are asked to add up emissions by country since 1900 to find out how the countries compare in cumulative emissions, and we learn why this number is relevant. Students also learn the difference between carbon emissions and concentrations, tying together some lessons on the carbon cycle. Students discover the complex role of several countries in climate change, showing them how complicated a climate change solution policy can be.

Phonological loop affects children's interpretations of explicit but not ambiguous questions: Research on links between working memory and referent assignment.

PubMed

Meng, Xianwei; Murakami, Taro; Hashiya, Kazuhide

2017-01-01

Understanding the referent of other's utterance by referring the contextual information helps in smooth communication. Although this pragmatic referential process can be observed even in infants, its underlying mechanism and relative abilities remain unclear. This study aimed to comprehend the background of the referential process by investigating whether the phonological loop affected the referent assignment. A total of 76 children (43 girls) aged 3-5 years participated in a reference assignment task in which an experimenter asked them to answer explicit (e.g., "What color is this?") and ambiguous (e.g., "What about this?") questions about colorful objects. The phonological loop capacity was measured by using the forward digit span task in which children were required to repeat the numbers as an experimenter uttered them. The results showed that the scores of the forward digit span task positively predicted correct response to explicit questions and part of the ambiguous questions. That is, the phonological loop capacity did not have effects on referent assignment in response to ambiguous questions that were asked after a topic shift of the explicit questions and thus required a backward reference to the preceding explicit questions to detect the intent of the current ambiguous questions. These results suggest that although the phonological loop capacity could overtly enhance the storage of verbal information, it does not seem to directly contribute to the pragmatic referential process, which might require further social cognitive processes.

Regional variations in the management of testicular or ovotesticular disorders of sex development.

PubMed

Josso, N; Audi, L; Shaw, G

2011-01-01

Disorders of sex development arise in parts of the world with different socio-economic and cultural characteristics. We wished to determine the regional variations in the management of these conditions. A questionnaire was e-mailed to the 650 members of the European Society for Paediatric Endocrinology (ESPE), an international society with a mainly European membership but which also includes professionals from other continents. Results were subjected to statistical analysis. A total of 62 answers were received, a satisfactory rate given that not all members are involved in this issue. Results show statistically significant regional differences for available diagnostic resources, age of the patient at gender assignment, parameters considered important for gender assignment, and timing of discussion of various issues with parents and patient. The regional variations exist not only between different continents, as already demonstrated by others, but also between Northern, Latin and Eastern European countries. This suggests that 'one-fits-all' guidelines for management are not appropriate. Copyright © 2011 S. Karger AG, Basel.

Effects of structured versus non-structured learning on achievement and attitudes of fifth graders in a public aquarium

NASA Astrophysics Data System (ADS)

Kafka, Merryl Audrey

The investigator analyzed the main effect of a structured-learning experience in an informal setting, as well as interactions between the students' learning-style variations toward the element of structure and the imposed instructional conditions. The subjects consisted of 170 students enrolled in two public schools located in Brooklyn, New York. The students were predominantly a White multi-ethnic population consisting of 118 Caucasians, 25 Hispanics, 24 Asians, and 3 African-Americans. Three randomly assigned classes (n = 81) were provided trip sheets, which directed students on how to learn new information with written questions and directives. Three randomly assigned non-structured classes (n = 89) experienced the same exhibit in a free-form manner. Science-based criterion-referenced pre- and posttests were administered, in addition to Learning Style Inventories (Dunn, Dunn, & Price, 1996) and a modified Semantic Differential Scale (Pizzo, 1981), which was used to measure attitudinal levels. The non-structured group had access to similar content information in the form of exhibit graphics, but apparently they chose not to read it as carefully or engage in the information-seeking process as intensely as the students equipped with trip sheets. Analysis of covariance (ANCOVA) indicated that a structured-learning experience produced significantly higher science-achievement test scores than in a non-structured-learning experience (p = .0001). In addition, there was no single learning-style variation (preference, aversion, or no preference) to structure that produced significantly higher gains than another. Furthermore, attitudinal scores were not significantly different between structured and non-structured groups, as well as among homogeneous subsets of students with learning-style variations that matched, mismatched, or indicated no-preferenced positions on the element of structure. Hence, a moderate amount of structure resulted in academic gains without diminishing attitudinal scores. The fact that students' learning-style variations for sociological, design, and perceptual preferences were simultaneously accommodated in this setting may have contributed to the overall positive effects of this structure-based intervention. The diversified teaching resources of the exhibit and the sense of self-empowerment in a student-directed environment may have elevated students' attitudes regardless of their learning-style need for structure. The students' acceptance of a trip sheet that promoted the understanding of science concepts may have contributed to academic success.

The impact of spatial and temporal patterns on multi-cellular behavior

NASA Astrophysics Data System (ADS)

Nikolic, Djordje L.

What makes a fruit fly a fruit fly? Essentially this question stems from one of the most fascinating problems in biology: how a single cell (fertilized egg) can give rise to a fully grown animal. To be able to answer this question, the importance to how spatial and temporal patterns of gene and protein expression influence the development of an organism must be understood. After all, fruit fly larvae are segmented, while fertilized eggs are not. Pattern formation is fundamental to establishing this organization of the developing embryo with the ultimate goal being the precise arrangements of specialized cells and tissues within each organ in an adult organism. The research presented here showcases the examples of studies that assess the impact spatial and temporal protein patterns have on the behavior of a collection of cells. By introducing new experimental, non-traditional techniques we developed model systems that allowed us to examine the dependence of the strength of adhesion of cells on the protein organization on sub-cellular, micron length scales, and to investigate how epithelial cell sheets coordinate their migration incorporating individual cell locomotion, molecular signal propagation and different boundary conditions. The first part of this dissertation presents a photolithography-based silanization patterning technique that allowed us to homogeneously pattern large areas with high precision. This method is then applied to organizing cell adhesion-promoting proteins on surfaces for the purposes of studying and manipulating cell behavior. We show how the strength of adhesion is dependent on high local density of an adhesive extracellular matrix protein fibronectin. The varied appeal of this technique is exhibited by showing its applicability to pattern stretched DNA, too. The second part of this dissertation focuses on the impact of spatial and temporal propagation of a molecular signal (ERK 1/2 MAPK) in migrating epithelial sheets during wound healing. By tracking the motion of individual cells within the sheet under the three constructed conditions, we show how the dynamics of the individual cells' motion is responsible for the coordinated migration of the sheet in accordance with the activation of ERK 1/2 MAPK.

Predicting the effects of unmodeled dynamics on an aircraft flight control system design using eigenspace assignment

NASA Technical Reports Server (NTRS)

Johnson, Eric N.; Davidson, John B.; Murphy, Patrick C.

1994-01-01

When using eigenspace assignment to design an aircraft flight control system, one must first develop a model of the plant. Certain questions arise when creating this model as to which dynamics of the plant need to be included in the model and which dynamics can be left out or approximated. The answers to these questions are important because a poor choice can lead to closed-loop dynamics that are unpredicted by the design model. To alleviate this problem, a method has been developed for predicting the effect of not including certain dynamics in the design model on the final closed-loop eigenspace. This development provides insight as to which characteristics of unmodeled dynamics will ultimately affect the closed-loop rigid-body dynamics. What results from this insight is a guide for eigenstructure control law designers to aid them in determining which dynamics need or do not need to be included and a new way to include these dynamics in the flight control system design model to achieve a required accuracy in the closed-loop rigid-body dynamics. The method is illustrated for a lateral-directional flight control system design using eigenspace assignment for the NASA High Alpha Research Vehicle (HARV).

The knowledge of expert nurses and the practical-reflective rationality.

PubMed

Pina Queirós, Paulo Joaquim

2015-01-01

To identify the characteristics of an expert nurse. A group of 49 nurses starting their Master's degree was asked to answer the following question: ''Which characteristics and skills distinguish a novice from an expert nurse?'' The answers were analyzed and classified based on Bardin's content analysis. Through a three-stage classification process, the competences and skills assigned to expert nurses were divided into 17 categories. These nurses showed wide-ranging skills and acquired meta-competencies. Expert nurses are characterized by their leadership, supervision and ability to manage change, as well as their communication and relational skills. They have the ability to act reflectively, plan, systematize and consistently assess; they also show more dexterity. They have more adaptive skills, confidence and achieve a broader view. They are competent while managing conflicts and stress, as well as articulating theory and practice; they create knowledge, make use of research, respond to complex situations and are capable of making decisions. Expert nurses have anticipation skills, insight, use detailed observation, take immediate action and are able to define priorities; they keep context in mind and have a tendency for specialization.

Using a pedagogical approach to integrate evidence-based teaching in an undergraduate women's health course.

PubMed

Dawley, Katy; Bloch, Joan Rosen; Suplee, Patricia Dunphy; McKeever, Amy; Scherzer, Gerri

2011-06-01

Evidence-based practice (EBP) is promoted as a foundation for nursing practice. However, the 2005 U.S. survey of nurses revealed that they do not have requisite skills for EBP. PURPOSE AND GOALS: To evaluate a pedagogical approach aimed at (1) fostering undergraduate nursing students EBP competencies, and (2) identifying gaps in the literature to direct future women's health research. A secondary analysis of data abstracted from required EBP clinical journals for an undergraduate women's health course in which students (n = 198) were asked to find evidence to answer their clinical questions. Content analysis was used to identify main themes of the topics of inquiry. Students identified 1,808 clinical questions and 30.3% (n = 547) of these could not be answered or supported by evidence in the literature. This assignment was an important teaching and assessment tool for EBP. Questions reflected critical thinking and quest for in-depth knowledge to support nursing practice. Some students lacked skills in searching databases and a significant number of knowledge gaps were identified that can direct women's health research. Copyright ©2010 Sigma Theta Tau International.

One Method for Inhibiting the Copying of Online Homework

NASA Astrophysics Data System (ADS)

Busch, Hauke

2017-10-01

Over the last several years online homework solutions have become ever more accessible to students. This is due in part to programs like Yahoo Answers, Chegg, publisher solution manuals, and other web resources that are readily available online. The student can easily search any physics homework problem posted on the web in a matter of seconds and have the solution. The results of this are an apparent increase in students copying the answers without solving the problem, which may lead to an increase in homework scores but a reduction in exam scores and an overall lower grade in the class. A secondary effect that may be observed is that tutoring centers, recitations, and supplemental instructor sessions have reduced student attendance. Some might say that the readily available solutions for homework systems such as MasteringPhysics (MP), WebAssign, etc. have greatly diminished them as a teaching tool, and for grading and assessing students' performance in a course. It is the purpose of this paper to offer a possible solution for preventing students from potentially copying online homework solutions.

Are safety data sheets for cleaning products used in Norway a factor contributing to the risk of workers exposure to chemicals?

PubMed

Suleiman, Abdulqadir M; Svendsen, Kristin V H

2014-10-01

Cleaning products are considered less hazardous than those used in other sectors. Suppliers and distributors are less conscientious when it comes to informing users on health risks. The aim of the study was to elaborate on the usefulness and clarity of information in the safety data sheets (SDS) for cleaning products, and considering if the use of these SDSs can be seen as a risk factor towards occupational exposure to hazardous chemicals in the sector. Safety data sheets were selected based on the risk level of the product assigned in an industrial sector scheme. 320 SDSs for cleaning products were reviewed. Constituent components found in the products over a given threshold were listed and available information thereof used to assess the perceived non-hazard consideration of the chemicals. The contents of the SDSs was generic and mostly incomplete. Safety measures and health information lacked sufficient specificity despite varying compositions and concentrations of components. There is generally incompatibility between mentioned sections on the suggested non-hazardous nature of the products and health effects. Not all substances used in these products have harmonized classifications, which makes them open to various classification of the products and the suggested safety measures. This results in different companies classifying similar products differently. Risk management measures and suggested personal protective equipment (PPEs) are given haphazardly. Physical properties relevant to risk assessment are not included. The safety data sheets are ambiguous, and they lack relevant and important information. Inadequate information and risk assessment concerning the products can lead to workers being exposed to hazardous chemicals. Underestimation of the hazard contribution of the components of the products and the insufficient, non-objective mention of appropriate control and protective measures are the major contributing elements. There is a need to test the products in order to establish health effects and product specific safety measures.

Silk: Optical Properties over 12.6 Octaves THz-IR-Visible-UV Range

PubMed Central

Balčytis, Armandas; Ryu, Meguya; Wang, Xuewen; Novelli, Fabio; Seniutinas, Gediminas; Du, Shan; Wang, Xungai; Li, Jingliang; Davis, Jeffrey; Appadoo, Dominique; Morikawa, Junko; Juodkazis, Saulius

2017-01-01

Domestic (Bombyx mori) and wild (Antheraea pernyi) silk fibers were characterised over a wide spectral range from THz 8 cm−1 (λ= 1.25 mm, f= 0.24 THz) to deep-UV 50×103 cm−1 (λ= 200 nm, f= 1500 THz) wavelengths or over a 12.6 octave frequency range. Spectral features at β-sheet, α-coil and amorphous fibroin were analysed at different spectral ranges. Single fiber cross sections at mid-IR were used to determine spatial distribution of different silk constituents and revealed an α-coil rich core and more broadly spread β-sheets in natural silk fibers obtained from wild Antheraea pernyi moths. Low energy T-ray bands at 243 and 229 cm−1 were observed in crystalline fibers of domestic and wild silk fibers, respectively, and showed no spectral shift down to 78 K temperature. A distinct 20±4 cm−1 band was observed in the crystalline Antheraea pernyi silk fibers. Systematic analysis and assignment of the observed spectral bands is presented. Water solubility and biodegradability of silk, required for bio-medical and sensor applications, are directly inferred from specific spectral bands. PMID:28772716

HEALTHY study school food service revenue and expense report.

PubMed

Treviño, Roberto P; Pham, Trang; Mobley, Connie; Hartstein, Jill; El Ghormli, Laure; Songer, Thomas

2012-09-01

Food service directors have a concern that federal reimbursement is not meeting the demands of increasing costs of healthier meals. The purpose of this article is to report the food option changes and the annual revenues and expenses of the school food service environment. The HEALTHY study was a 3-year (2006 to 2009) randomized, cluster-designed trial conducted in 42 middle schools at 7 field centers. The schools selected had at least 50% of students who were eligible for free or reduced-price lunch or who belonged to a minority group. A randomly assigned half of the HEALTHY schools received a school health intervention program consisting of 4 integrated components: nutrition, physical activity, behavioral knowledge and skills, and social marketing. The nutrition component consisted of changing the meal plans to meet 5 nutrition goals. Revenue and expense data were collected from income statements, federal meal records, à la carte sale sheets, school store sale sheets, donated money/food records, and vending machines. Although more intervention schools reached the nutritional goals than control schools, revenues and expenses were not significantly different between groups. The HEALTHY study showed no adverse effect of school food policies on food service finances. © 2012, American School Health Association.

HEALTHY Study School Food Service Revenue and Expense Report

PubMed Central

Treviño, Roberto P.; Pham, Trang; Mobley, Connie; Hartstein, Jill; El ghormli, Laure; Songer, Thomas

2013-01-01

BACKGROUND Food service directors have a concern that federal reimbursement is not meeting the demands of increasing costs of healthier meals. The purpose of this article is to report the food option changes and the annual revenues and expenses of the school food service environment. METHODS The HEALTHY study was a 3-year (2006 to 2009) randomized, cluster-designed trial conducted in 42 middle schools at 7 field centers. The schools selected had at least 50% of students who were eligible for free or reduced-price lunch or who belonged to a minority group. A randomly assigned half of the HEALTHY schools received a school health intervention program consisting of 4 integrated components: nutrition, physical activity, behavioral knowledge and skills, and social marketing. The nutrition component consisted of changing the meal plans to meet 5 nutrition goals. Revenue and expense data were collected from income statements, federal meal records, à la carte sale sheets, school store sale sheets, donated money/food records, and vending machines. RESULTS Although more intervention schools reached the nutritional goals than control schools, revenues and expenses were not significantly different between groups. CONCLUSION The HEALTHY study showed no adverse effect of school food policies on food service finances. PMID:22882105

Renal stone clinic survey: calcium stone formers' self-declared understanding of and adherence to physician's recommendations.

PubMed

Hess, Bernhard

2017-08-01

Nothing is known about how well stone formers understand physician's explanations of stone formation, and a few data are available on adherence to provided recommendations. In this study, two groups of recurrent calcium stone formers (RCSFs) were compared. Group 1: 153 consecutive RCSF (118 men, 35 women) referred 1/2011-6/2014. At least 3 months after a 60-75 min consultation explaining metabolic evaluation and therapeutic measures, RCSF received a questionnaire by mail, regarding understanding of stone formation and adherence to therapeutic recommendations (diet, lifestyle, drug treatment). Response rate was 62 %. Group 2 (control): 81 consecutive RCSFs referred 7/2014-3/2016 (60 men, 21 women) were asked to answer the same questionnaire in the stone center while waiting for their follow-up consultation 3 months after starting prevention; response rate was 100 %. Alkali citrate was prescribed in 45 %. Answer sheets were analyzed anonymously, and frequencies of answers were compared by Chi-square test. 67 % (group 1) and 62 % (group 2) indicated >80 % understanding of the given information (NS). Over 80 % adherence to recommendations occurred in 26 and 30 % (NS). Most frequent changes in dietary/lifestyle habits were increases in calcium (93 vs. 89 %) and fluid intakes (81 vs. 78 %); lowering psychosocial stress (23 vs. 24 %) was least popular. Adherence to 100 % on 6-7 days/week was significantly more frequent for medication than for dietary/lifestyle interventions, both in group 1 (84 vs. 24 %, p < 0.001) and group 2 (91 vs. 28 %, p < 0.001). (1) results do not differ whether RCSFs are voluntarily participating by mail or asked to answer questionnaires in the stone clinic; (2) pathophysiologic explanations of stone disease are understood to >80 % by 2/3 of RCSFs; (3) after 3 months, perfect adherence to recommended treatment is more frequent on alkali citrate than on dietary/lifestyle measures; and (4) increasing calcium and fluid intake are the most popular dietary measures.

Constraining Future Sea Level Rise Estimates from the Amundsen Sea Embayment, West Antarctica

NASA Astrophysics Data System (ADS)

Nias, I.; Cornford, S. L.; Edwards, T.; Gourmelen, N.; Payne, A. J.

2016-12-01

The Amundsen Sea Embayment (ASE) is the primary source of mass loss from the West Antarctic Ice Sheet. The catchment is particularly susceptible to grounding line retreat, because the ice sheet is grounded on bedrock that is below sea level and deepening towards its interior. Mass loss from the ASE ice streams, which include Pine Island, Thwaites and Smith glaciers, is a major uncertainty on future sea level rise, and understanding the dynamics of these ice streams is essential to constraining this uncertainty. The aim of this study is to construct a distribution of future ASE sea level contributions from an ensemble of ice sheet model simulations and observations of surface elevation change. A 284 member ensemble was performed using BISICLES, a vertically-integrated ice flow model with adaptive mesh refinement. Within the ensemble parameters associated with basal traction, ice rheology and sub-shelf melt rate were perturbed, and the effect of bed topography and sliding law were also investigated. Initially each configuration was run to 50 model years. Satellite observations of surface height change were then used within a Bayesian framework to assign likelihoods to each ensemble member. Simulations that better reproduced the current thinning patterns across the catchment were given a higher score. The resulting posterior distribution of sea level contributions is narrower than the prior distribution, although the central estimates of sea level rise are similar between the prior and posterior. The most extreme simulations were eliminated and the remaining ensemble members were extended to 200 years, using a simple melt rate forcing.

Contact Prediction for Beta and Alpha-Beta Proteins Using Integer Linear Optimization and its Impact on the First Principles 3D Structure Prediction Method ASTRO-FOLD

PubMed Central

Rajgaria, R.; Wei, Y.; Floudas, C. A.

2010-01-01

An integer linear optimization model is presented to predict residue contacts in β, α + β, and α/β proteins. The total energy of a protein is expressed as sum of a Cα – Cα distance dependent contact energy contribution and a hydrophobic contribution. The model selects contacts that assign lowest energy to the protein structure while satisfying a set of constraints that are included to enforce certain physically observed topological information. A new method based on hydrophobicity is proposed to find the β-sheet alignments. These β-sheet alignments are used as constraints for contacts between residues of β-sheets. This model was tested on three independent protein test sets and CASP8 test proteins consisting of β, α + β, α/β proteins and was found to perform very well. The average accuracy of the predictions (separated by at least six residues) was approximately 61%. The average true positive and false positive distances were also calculated for each of the test sets and they are 7.58 Å and 15.88 Å, respectively. Residue contact prediction can be directly used to facilitate the protein tertiary structure prediction. This proposed residue contact prediction model is incorporated into the first principles protein tertiary structure prediction approach, ASTRO-FOLD. The effectiveness of the contact prediction model was further demonstrated by the improvement in the quality of the protein structure ensemble generated using the predicted residue contacts for a test set of 10 proteins. PMID:20225257

How to work with FMLA and ADA when granting leave.

PubMed

Collins, C J; Neuman, A B

1998-10-16

There is much confusion among employers on how to interpret rights and responsibilities under the Americans with Disabilities Act (ADA) and the Family and Medical Leave Act (FMLA). In many cases, the guidelines seem contradictory. Labor attorney Christopher J. Collins says that the ADA is basically a civil rights act, designed to protect the disabled from discrimination, while FMLA is a labor standards and leave law. Commonly-asked questions are answered, including the amount of leave an employee is entitled to, the amount of information that can be requested from an employee, and the options for dealing with employees who cannot perform assigned tasks.

The USL NASA PC R and D interactive presentation development system

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Moreau, Dennis R.

1984-01-01

The Interactive Presentation Development System (IPFS) is a highly interactive system for creating, editing, and displaying video presentation sequences, e.g., for developing and presenting displays of instructional material similiar to overhead transparency or slide presentations. However, since this system is PC-based, users (instructors) can step through sequences forward or backward, focusing attention to areas of the display with special cursor pointers. Additionally, screen displays may be dynamically modified during the presentation to show assignments or to answer questions, much like a traditional blackboard. This system is now implemented at the University of Southwestern Louisiana for use within the piloting phases of the NASA contract work.

Improving Measures of Sexual and Gender Identity in English and Spanish to Identify LGBT Older Adults in Surveys.

PubMed

Michaels, Stuart; Milesi, Carolina; Stern, Michael; Viox, Melissa Heim; Morrison, Heather; Guerino, Paul; Dragon, Christina N; Haffer, Samuel C

2017-12-01

The goal of this research is to advance the study of health disparities faced by older sexual and gender minorities by assessing comprehension of and improving measures of sexual and gender identity in surveys. Cognitive interviews were conducted by expert interviewers with 48 non-lesbian, gay, bisexual, and transgender (non-LGBT) and 9 LGBT older English and Spanish speakers. All respondents were able to answer questions about their sex assigned at birth and current gender identity successfully despite some cisgender respondents' lack of clear understanding of the transgender response option. On the contrary, while the vast majority of English speakers could answer the question about their sexual identity successfully, almost 60% of the non-LGBT Spanish speakers did not select the "heterosexual, that is, not gay (or lesbian)" response category. Qualitative probing of their response process pointed mainly to difficulties understanding the term "heterosexual," leading to their choosing "something else" or saying that they didn't know how to answer. A second round of testing of alternative response categories for the sexual identity question with Spanish speakers found a marked improvement when offered "not gay (or lesbian), that is, heterosexual" instead of beginning with the term "heterosexual." This research adds to our understanding of gender and sexual identity questions appropriate for population surveys with older adults. Inclusion of these measures in surveys is a crucial step in advancing insights into the needs of and disparities faced by LGBT older adults.

Effective variations of peer instruction: The effects of peer discussions, committing to an answer, and reaching a consensus

NASA Astrophysics Data System (ADS)

Lasry, Nathaniel; Charles, Elizabeth; Whittaker, Chris

2016-08-01

Peer Instruction (PI) is a widely used student-centered pedagogy, but one that is used differently by different instructors. While all PI instructors survey their students with conceptual questions, some do not allow students to discuss with peers. We studied the effect of peer discussion by polling three groups of students (N = 86) twice on the same set of nine conceptual questions. The three groups differed in the tasks assigned between the first and second poll: the first group discussed, the second reflected in silence, and the third was distracted so they could neither reflect nor discuss. Comparing score changes between the first and second poll, we find minimal increases in the distraction condition (3%), sizable increases in the reflection condition (10%), and significantly larger increases in the peer discussion condition (21%). We also examined the effect of committing to an answer before peer discussion and reaching a consensus afterward. We compared a lecture-based control section to three variations of PI that differed in their requirement to commit to an answer or reach consensus (N = 108). We find that all PI groups achieve greater conceptual learning and traditional problem solving than lecture-based instruction. We find one difference between these groups: the absence of consensus building is related to a significant decrease in expert views and beliefs. Our findings can therefore be used to make two recommendations: always use peer discussions and consider asking students to reach a consensus before re-polling.

Phonological loop affects children’s interpretations of explicit but not ambiguous questions: Research on links between working memory and referent assignment

PubMed Central

Murakami, Taro; Hashiya, Kazuhide

2017-01-01

Understanding the referent of other’s utterance by referring the contextual information helps in smooth communication. Although this pragmatic referential process can be observed even in infants, its underlying mechanism and relative abilities remain unclear. This study aimed to comprehend the background of the referential process by investigating whether the phonological loop affected the referent assignment. A total of 76 children (43 girls) aged 3–5 years participated in a reference assignment task in which an experimenter asked them to answer explicit (e.g., “What color is this?”) and ambiguous (e.g., “What about this?”) questions about colorful objects. The phonological loop capacity was measured by using the forward digit span task in which children were required to repeat the numbers as an experimenter uttered them. The results showed that the scores of the forward digit span task positively predicted correct response to explicit questions and part of the ambiguous questions. That is, the phonological loop capacity did not have effects on referent assignment in response to ambiguous questions that were asked after a topic shift of the explicit questions and thus required a backward reference to the preceding explicit questions to detect the intent of the current ambiguous questions. These results suggest that although the phonological loop capacity could overtly enhance the storage of verbal information, it does not seem to directly contribute to the pragmatic referential process, which might require further social cognitive processes. PMID:29088282

Interdisciplinary Subject "Yakugaku Nyumon" for First-year Students Constructed with Lectures and Problem-based Learning.

PubMed

Yamaki, Kouya; Ueda, Masafumi; Ueda, Kumiko; Emoto, Noriaki; Mizutani, Nobuaki; Ikeda, Koji; Yagi, Keiko; Tanaka, Masafumi; Habu, Yasushi; Nakayama, Yoshiaki; Takeda, Norihiko; Moriwaki, Kensuke; Kitagawa, Shuji

2016-01-01

In 2013, Kobe Pharmaceutical University established "Yakugaku Nyumon", an interdisciplinary course, which consists of omnibus lectures and problem-based learning (PBL) on topics ranging from basic to clinical subjects. The themes of the PBL were original ones; "Study from package inserts of aspirin", which aimed to reinforce the contents of the interdisciplinary lectures, and "Let's think about aspirin derivatives (super-aspirin)", which aimed to engender an interest in studying pharmacy. The PBL featured questions from teachers to help with study and was therefore referred to as "question-led PBL" (Q-PBL). The Q-PBL regarding aspirin derivatives began with preparing answers to the questions for a small group discussion (SGD) as an assignment, followed by a SGD, a presentation, and peer-feedback. From an analysis of the questionnaire survey, it was found that students considered the Q-PBL satisfying and that they had achieved the 4 aims: (1) to increase the motivation to study, (2) to enhance an understanding of the relations and significance of basic and clinical sciences, (3) to comprehend the learning content, and (4) to recognize the importance of communication. The Q-PBL with assignments has two favorable points. One is that the first-year students can challenge difficult and high-level questions when they are given these as assignments. The other is that students, who are unfamiliar with SGD can engage in discussions with other students using the knowledge gained from the assignment. The introduction of omnibus lectures and Q-PBL, along with these improvements in theme, application, and review process, promises increased learning efficacy at the university.

Does part-time sick leave help individuals with mental disorders recover lost work capacity?

PubMed

Andrén, Daniela

2014-06-01

This paper aims to answer the question whether combining sick leave with some hours of work can help employees diagnosed with a mental disorder (MD) increase their probability of returning to work. Given the available data, this paper analyzes the impact of part-time sick leave (PTSL) on the probability of fully recovering lost work capacity for employees diagnosed with an MD. The effects of PTSL on the probability of fully recovering lost work capacity are estimated by a discrete choice one-factor model using data on a nationally representative sample extracted from the register of the National Agency of Social Insurance in Sweden and supplemented with information from questionnaires. All individuals in the sample were 20-64 years old and started a sickness spell of at least 15 days between 1 and 16 February 2001. We selected all employed individuals diagnosed with an MD, with a final sample of 629 individuals. The results show that PTSL is associated with a low likelihood of full recovery, yet the timing of the assignment is important. PTSL's effect is relatively low (0.015) when it is assigned in the beginning of the spell but relatively high (0.387), and statistically significant, when assigned after 60 days of full-time sick leave (FTSL). This suggests efficiency improvements from assigning employees with an MD diagnosis, when possible, to PTSL. The employment gains will be enhanced if employees with an MD diagnosis are encouraged to return to work part-time after 60 days or more of FTSL.

Short-period oscillations in photoemission from thin films of Cr(100)

NASA Astrophysics Data System (ADS)

Vyalikh, Denis V.; Zahn, Peter; Richter, Manuel; Dedkov, Yu. S.; Molodtsov, S. L.

2005-07-01

Angle-resolved photoemission (PE) study of thin films of Cr grown on Fe(100) reveals thickness-dependent short-period oscillations of the PE intensity close to the Fermi energy at k‖˜0 . The oscillations are assigned to quantum-well states (QWS) caused by the nesting between the Fermi-surface sheets around the Γ and the X points in the Brillouin zone of antiferromagnetic Cr. The experimental data are confirmed by density-functional calculations applying a screened Korringa-Kohn-Rostoker Green’s function method. The period of the experimentally observed QWS oscillations amounts to about 2.6 monolayers and is larger than the fundamental 2-monolayer period of antiferromagnetic coupling in Cr.

The vibrational spectrum of the hydrated alanine-leucine peptide in the amide region from IR experiments and first principles calculations

NASA Astrophysics Data System (ADS)

Hassan, Irtaza; Donati, Luca; Stensitzki, Till; Keller, Bettina G.; Heyne, Karsten; Imhof, Petra

2018-04-01

We have combined infrared (IR) experiments with molecular dynamics (MD) simulations in solution at finite temperature to analyse the vibrational signature of the small floppy peptide Alanine-Leucine. IR spectra computed from first-principles MD simulations exhibit no distinct differences between conformational clusters of α -helix or β -sheet-like folds with different orientations of the bulky leucine side chain. All computed spectra show two prominent bands, in good agreement with the experiment, that are assigned to the stretch vibrations of the carbonyl and carboxyl group, respectively. Variations in band widths and exact maxima are likely due to small fluctuations in the backbone torsion angles.

Anesthesiology Journal club assessment by means of semantic changes.

PubMed

Vieira, Joaquim Edson; Torres, Marcelo Luís Abramides; Pose, Regina Albanese; Auler, José Otávio Costa Junior

2014-01-01

the interactive approach of a journal club has been described in the medical education literature. The aim of this investigation is to present an assessment of journal club as a tool to address the question whether residents read more and critically. this study reports the performance of medical residents in anesthesiology from the Clinics Hospital - University of São Paulo Medical School. All medical residents were invited to answer five questions derived from discussed papers. The answer sheet consisted of an affirmative statement with a Likert type scale (totally disagree-disagree-not sure-agree-totally agree), each related to one of the chosen articles. The results were evaluated by means of item analysis - difficulty index and discrimination power. residents filled one hundred and seventy three evaluations in the months of December 2011 (n=51), July 2012 (n=66) and December 2012 (n=56). The first exam presented all items with straight statement, second and third exams presented mixed items. Separating "totally agree" from "agree" increased the difficulty indices, but did not improve the discrimination power. the use of a journal club assessment with straight and inverted statements and by means of five points scale for agreement has been shown to increase its item difficulty and discrimination power. This may reflect involvement either with the reading or the discussion during the journal meeting. Copyright © 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

Process-based Assignment-Setting Change for Support of Overcoming Bottlenecks in Learning by Problem-Posing in Arithmetic Word Problems

NASA Astrophysics Data System (ADS)

Supianto, A. A.; Hayashi, Y.; Hirashima, T.

2017-02-01

Problem-posing is well known as an effective activity to learn problem-solving methods. Monsakun is an interactive problem-posing learning environment to facilitate arithmetic word problems learning for one operation of addition and subtraction. The characteristic of Monsakun is problem-posing as sentence-integration that lets learners make a problem of three sentences. Monsakun provides learners with five or six sentences including dummies, which are designed through careful considerations by an expert teacher as a meaningful distraction to the learners in order to learn the structure of arithmetic word problems. The results of the practical use of Monsakun in elementary schools show that many learners have difficulties in arranging the proper answer at the high level of assignments. The analysis of the problem-posing process of such learners found that their misconception of arithmetic word problems causes impasses in their thinking and mislead them to use dummies. This study proposes a method of changing assignments as a support for overcoming bottlenecks of thinking. In Monsakun, the bottlenecks are often detected as a frequently repeated use of a specific dummy. If such dummy can be detected, it is the key factor to support learners to overcome their difficulty. This paper discusses how to detect the bottlenecks and to realize such support in learning by problem-posing.

Learning Bridge: Curricular Integration of Didactic and Experiential Education

PubMed Central

Arendt, Cassandra S.; Cawley, Pauline; Buhler, Amber V.; Elbarbry, Fawzy; Roberts, Sigrid C.

2010-01-01

Objectives To assess the impact of a program to integrate introductory pharmacy practice experiences with pharmaceutical science topics by promoting active learning, self-directed learning skills, and critical-thinking skills. Design The Learning Bridge, a curriculum program, was created to better integrate the material first-year (P1) students learned in pharmaceutical science courses into their introductory pharmacy practice experiences. Four Learning Bridge assignments required students to interact with their preceptors and answer questions relating to the pharmaceutical science material concurrently covered in their didactic courses. Assessment Surveys of students and preceptors were conducted to measure the effectiveness of the Learning Bridge process. Feedback indicated the Learning Bridge promoted students' interaction with their preceptors as well as development of active learning, self-directed learning, and critical-thinking skills. Students also indicated that the Learning Bridge assignments increased their learning, knowledge of drug information, and comprehension of relevant data in package inserts. Conclusion The Learning Bridge process integrated the didactic and experiential components of the curriculum, enhancing student learning in both areas, and offered students educational opportunities to interact more with their preceptors. PMID:20498741

Functions and principles in the management of bombing mass casualty incidents: lessons learned at the Tel-Aviv Souraski Medical Center.

PubMed

Kluger, Yoram; Mayo, Ami; Soffer, Dror; Aladgem, David; Halperin, Pinchas

2004-12-01

Mass casualty incidents (MCI) resulting from terrorist bombings pose special problems and may overwhelm even the most experienced trauma centre. Although role assignments for MCI management and control are documented, we would like to share several aspects that we have found to be crucial for the management of terrorist bombing MCI. Twelve topics and possible answers were brought up and discussed extensively in MCI debriefing sessions in our institution. They were of two main categories: assignments and functions of key personnel, and principles and definitions. The first category includes the Triage Officer, the Medical Director, the Administrative Director, the Head Nurse, the Emergency Medical System Coordinator, the Blood Bank Liaison, and the trauma teams. The second category encompasses the concept of triage hospital, the unidirectional patient flow, ancillary evaluation during MCI, the consultancy, and tertiary survey. All were identified as critical for proper event handling. The integration and implementation of the topics discussed throughout the medical system may enable emergency departments to handle MCI resulting from terrorist bombings better.

Using parentage analysis to examine gene flow and spatial genetic structure.

PubMed

Kane, Nolan C; King, Matthew G

2009-04-01

Numerous approaches have been developed to examine recent and historical gene flow between populations, but few studies have used empirical data sets to compare different approaches. Some methods are expected to perform better under particular scenarios, such as high or low gene flow, but this, too, has rarely been tested. In this issue of Molecular Ecology, Saenz-Agudelo et al. (2009) apply assignment tests and parentage analysis to microsatellite data from five geographically proximal (2-6 km) and one much more distant (1500 km) panda clownfish populations, showing that parentage analysis performed better in situations of high gene flow, while their assignment tests did better with low gene flow. This unusually complete data set is comprised of multiple exhaustively sampled populations, including nearly all adults and large numbers of juveniles, enabling the authors to ask questions that in many systems would be impossible to answer. Their results emphasize the importance of selecting the right analysis to use, based on the underlying model and how well its assumptions are met by the populations to be analysed.

Future ice ages and the challenges related to final disposal of nuclear waste: The Greenland Ice Sheet Hydrology Project

NASA Astrophysics Data System (ADS)

Lehtinen, A.; Claesson-Liljedahl, L.; Näslund, J.-O.; Ruskeeniemi, T.

2009-04-01

A deep geological repository for nuclear waste is designed to keep radiotoxic material separated from mankind and the environment for several hundreds of thousands of years. Within this time perspective glacial conditions are expected in high latitudes/Canada and North Europe. Climate induced changes such as the growth of ice sheets and permafrost will influence and alter the ground surface and subsurface environment, which may impact repository safety. In order to understand how climate change, particularly cooling and glaciation, might affect a repository in the long term, the use of present-day analogues helps to reduce the uncertainties and support the assumptions made in safety assessments. There are major uncertainties concerning hydrological processes related to glacial conditions. The impact of glaciations on any planned repository is a key consideration when performing safety assessments as it is one of the strongest perturbations related to climate change in the long term. The main aspects that need to be further investigated include: 1) to what extent does the meltwater produced by an ice sheet penetrates into the bedrock; 2) what is the pressure situation under an ice sheet, driving ground water flow; 3) how much oxygenated water will reach repository depth; 4) to what depth does glacial meltwater penetrate into the bedrock ; 5)what chemical composition does such water has when and if it reaches repository depth; and 6) can taliks (unfrozen ground in a permafrost area) act as concentrated discharge points of deep groundwater potentially transporting radionuclides in case of repository failure? Field data is needed in order to achieve a better and integrated understanding of the problems discussed above. Thus, research in a natural analogue site in Greenland has been planned and initiated by the Finnish (Posiva), Swedish (SKB) and Canadian (NWMO) nuclear waste management companies. The Greenland ice sheet and the Kangerlussuaq area (west Greenland) provides a good analogue for this purpose due to similarities in geology (in the selected study area), and the climate conditions and ice sheet size in Kangerlussuaq resemble the expected conditions in Fennoscandia during future glaciations. In 2005 and 2008 reconnaissance field trips were made to Kangerlussuaq, which confirmed the suitability of the area for the planned studies. According to the present Work Programme the investigations will be carried out in 2009-2012. The project is divided into four subprojects (SPA, SPB, SPC and SPD) addressing specific and different topics at or in relation to the ice margin: SPA (ice sheet hydrology and glacial groundwater formation); SPB (subglacial ice sheet hydrology), SPC (hydrogeochemistry and hydrogeology) and SPD (periglacial environment: biosphere and permafrost). The main objectives of SPA and SPB are to gain a better process understanding of supra- and subglacial hydrology. Qualitative and quantitative knowledge of the mechanisms, rates and distribution of the melt water recharge through the ice down to the bed, location and extension of warm-based areas and hydraulic pressure conditions at the base are the key issues to be studied. This will be made by meteorological observations, GPS measurements, radar surveys, drilling through the ice sheet and by ice sheet modelling. SPC will further study the fate of melt water by extending the investigations into the bedrock. It is assumed that the high hydraulic pressures at the ice sheet bed force water into the fracture network prevailing in the bedrock. However, it is not known how the fracture network behaves under loading, what is the proportion of recharging water compared to the drainage through the bed sediments, what is the intrusion depth, how long the meltwater can sustain its oxic nature and what chemical composition the recharging water has when and if it reaches repository depth (400-700 m). SPC seeks to answer these questions by drilling and instrumenting boreholes drilled into the bedrock and below the ice sheet. SPD is aiming at describing and studying processes acting in the periglacial environment affected by permafrost conditions. The observations will be used within the safety assessment biosphere programs. From the acquired results we will obtain data, which will allow us to develop better conceptual and numerical models for quantitative analysis of ice sheet hydrology and dynamics, groundwater flow, groundwater chemistry and hydro-mechanical couplings during glacial periods, by reducing uncertainties and better constraining the boundary conditions used in the models. Finally, this project concerns the first in situ investigation of the vital parameters needed to achieve a holistic and realistic understanding of how an ice sheet may impact a deep geological repository for spent nuclear waste and will provide the necessary integrated view of ice sheet hydrology and groundwater flow/chemistry needed when executing safety assessments for the geological repositories in Sweden, Finland and Canada.

Predicting uncertainty in future marine ice sheet volume using Bayesian statistical methods

NASA Astrophysics Data System (ADS)

Davis, A. D.

2015-12-01

The marine ice instability can trigger rapid retreat of marine ice streams. Recent observations suggest that marine ice systems in West Antarctica have begun retreating. However, unknown ice dynamics, computationally intensive mathematical models, and uncertain parameters in these models make predicting retreat rate and ice volume difficult. In this work, we fuse current observational data with ice stream/shelf models to develop probabilistic predictions of future grounded ice sheet volume. Given observational data (e.g., thickness, surface elevation, and velocity) and a forward model that relates uncertain parameters (e.g., basal friction and basal topography) to these observations, we use a Bayesian framework to define a posterior distribution over the parameters. A stochastic predictive model then propagates uncertainties in these parameters to uncertainty in a particular quantity of interest (QoI)---here, the volume of grounded ice at a specified future time. While the Bayesian approach can in principle characterize the posterior predictive distribution of the QoI, the computational cost of both the forward and predictive models makes this effort prohibitively expensive. To tackle this challenge, we introduce a new Markov chain Monte Carlo method that constructs convergent approximations of the QoI target density in an online fashion, yielding accurate characterizations of future ice sheet volume at significantly reduced computational cost.Our second goal is to attribute uncertainty in these Bayesian predictions to uncertainties in particular parameters. Doing so can help target data collection, for the purpose of constraining the parameters that contribute most strongly to uncertainty in the future volume of grounded ice. For instance, smaller uncertainties in parameters to which the QoI is highly sensitive may account for more variability in the prediction than larger uncertainties in parameters to which the QoI is less sensitive. We use global sensitivity analysis to help answer this question, and make the computation of sensitivity indices computationally tractable using a combination of polynomial chaos and Monte Carlo techniques.

A leader's framework for decision making. A leader's framework for decision making.

PubMed

Snowden, David J; Boone, Mary E

2007-11-01

Many executives are surprised when previously successful leadership approaches fail in new situations, but different contexts call for different kinds of responses. Before addressing a situation, leaders need to recognize which context governs it -and tailor their actions accordingly. Snowden and Boone have formed a new perspective on leadership and decision making that's based on complexity science. The result is the Cynefin framework, which helps executives sort issues into five contexts: Simple contexts are characterized by stability and cause-and-effect relationships that are clear to everyone. Often, the right answer is self-evident. In this realm of "known knowns," leaders must first assess the facts of a situation -that is, "sense" it -then categorize and respond to it. Complicated contexts may contain multiple right answers, and though there is a clear relationship between cause and effect, not everyone can see it. This is the realm of "known unknowns." Here, leaders must sense, analyze, and respond. In a complex context, right answers can't be ferreted out at all; rather, instructive patterns emerge if the leader conducts experiments that can safely fail. This is the realm of "unknown unknowns," where much of contemporary business operates. Leaders in this context need to probe first, then sense, and then respond. In a chaotic context, searching for right answers is pointless. The relationships between cause and effect are impossible to determine because they shift constantly and no manageable patterns exist. This is the realm of unknowables (the events of September 11, 2001, fall into this category). In this domain, a leader must first act to establish order, sense where stability is present, and then work to transform the situation from chaos to complexity. The fifth context, disorder, applies when it is unclear which of the other four contexts is predominant. The way out is to break the situation into its constituent parts and assign each to one of the other four realms. Leaders can then make decisions and intervene in contextually appropriate ways.

Development and Evaluation of a Pedagogical Tool to Improve Understanding of a Quality Checklist: A Randomised Controlled Trial

PubMed Central

Fourcade, Lola; Boutron, Isabelle; Moher, David; Ronceray, Lucie; Baron, Gabriel; Ravaud, Philippe

2007-01-01

Objective: The aim of this study was to develop and evaluate a pedagogical tool to enhance the understanding of a checklist that evaluates reports of nonpharmacological trials (CLEAR NPT). Design: Paired randomised controlled trial. Participants: Clinicians and systematic reviewers. Interventions: We developed an Internet-based computer learning system (ICLS). This pedagogical tool used many examples from published randomised controlled trials to demonstrate the main coding difficulties encountered when using this checklist. Randomised participants received either a specific Web-based training with the ICLS (intervention group) or no specific training. Outcome measures: The primary outcome was the rate of correct answers compared to a criterion standard for coding a report of randomised controlled trials with the CLEAR NPT. Results: Between April and June 2006, 78 participants were randomly assigned to receive training with the ICLS (39) or no training (39). Participants trained by the ICLS did not differ from the control group in performance on the CLEAR NPT. The mean paired difference and corresponding 95% confidence interval was 0.5 (−5.1 to 6.1). The rate of correct answers did not differ between the two groups regardless of the CLEAR NPT item. Combining both groups, the rate of correct answers was high or items related to allocation sequence (79.5%), description of the intervention (82.0%), blinding of patients (79.5%), and follow-up schedule (83.3%). The rate of correct answers was low for items related to allocation concealment (46.1%), co-interventions (30.3%), blinding of outcome assessors (53.8%), specific measures to avoid ascertainment bias (28.6%), and intention-to-treat analysis (60.2%). Conclusions: Although we showed no difference in effect between the intervention and control groups, our results highlight the gap in knowledge and urgency for education on important aspects of trial conduct. PMID:17479163

User questionnaire to evaluate the radiological workspace.

PubMed

van Ooijen, Peter M A; Koesoema, Allya P; Oudkerk, Matthijs

2006-01-01

Over the past few years, an increase in digitalization of radiology departments can be seen, which has a large impact on the work of the radiologists. This impact is not only demonstrated by the increased use of digital images but also by changing demands on the whole reading environment. In this study, we evaluated the satisfaction of our radiologists with our digital Picture Archival and Communication System environment and their workspace. This evaluation was performed by distribution of a questionnaire consisting of a score sheet and some open questions to all radiologists and residents. Out of 25 questionnaires, 12 were adequately answered and returned. Results clearly showed that most problems were present in the area of reading room design and layout and comfort and ergonomics. Based on the results from this study, adaptations were made and the results were also used in the planning of the redesign of the entire department of radiology.

Self-calibration performance in stereoscopic PIV acquired in a transonic wind tunnel

DOE PAGES

Beresh, Steven J.; Wagner, Justin L.; Smith, Barton L.

2016-03-16

Three stereoscopic PIV experiments have been examined to test the effectiveness of self-calibration under varied circumstances. Furthermore, we our measurements taken in a streamwise plane yielded a robust self-calibration that returned common results regardless of the specific calibration procedure, but measurements in the crossplane exhibited substantial velocity bias errors whose nature was sensitive to the particulars of the self-calibration approach. Self-calibration is complicated by thick laser sheets and large stereoscopic camera angles and further exacerbated by small particle image diameters and high particle seeding density. In spite of the different answers obtained by varied self-calibrations, each implementation locked onto anmore » apparently valid solution with small residual disparity and converged adjustment of the calibration plane. Thus, the convergence of self-calibration on a solution with small disparity is not sufficient to indicate negligible velocity error due to the stereo calibration.« less

Evidence for two interconverting protein isomers in the methotrexate complex of dihydrofolate reductase from Escherichia coli

DOE Office of Scientific and Technical Information (OSTI.GOV)

Falzone, C.J.; Benkovic, S.J.; Wright, P.E.

1991-02-26

Two-dimensional {sup 1}H NMR methods and a knowledge of the X-ray crystal structure have been used to make resonance assignments for the amino acid side chains of dihydrofolate reductase from Escherichia coli complexed with methotrexate. The H7 proton on the pteridine ring of methotrexate was found to have NOEs to the methyl protons of Leu-28 which were assigned by using the L28F mutant. These NOEs indicated that the orientation of the methotrexate pteridine ring is similar in both solution and crystal structures. During the initial assignment process, it became evident that many of the resonances in this complex, unlike thosemore » of the folate complex, are severally broadened or doubled. The observation of two distinct sets of resonances in a ratio of approximately 2:1 was attributed to the presence of two protein isomers. Many of the side chains with clearly doubled resonances were located in the {beta}-sheet and the active site. Preliminary studies on the apoprotein also revealed doubled resonances in the absence of the inhibitor, indicating the existence of the protein isomers prior to methotrexate binding. In contrast to the methotrexate complex, the binary complex with folate and the ternary MTX-NADPH-DHFR complex presented a single enzyme form. These results are proposed to reflect the ability of folate and NADPH to bind predominantly to one protein isomer.« less

Concentration-dependent effects of spermine on apoptosis and consequent generation of multilayer myotube sheets from mouse embryoid bodies in vitro.

PubMed

Saito, Mikako; Abe, Natsuki; Ishida, Ayano; Nakagawa, Shota; Matsuoka, Hideaki

2014-12-01

The concentration-dependent effect of spermine was investigated on the spermine-induced generation of multilayer myotube sheets (MMTS) from mouse embryoid bodies (EBs). During spermine treatment for 24 h, a monolayer cell sheet that had already grown radially from the periphery of an EB was exfoliated. The exfoliation was inhibited by z-VAD.fmk, indicating the occurrence of apoptosis, and inhibited also by aminoguanidine, indicating the involvement of amine oxidase. Following the exfoliation, the cell growth restarted from the fresh periphery of EB in a spermine-free medium and finally formed MMTS. To analyze the contribution of apoptosis to the cell death causing exfoliation, the numbers of apoptotic, necrotic, and 2nd apoptotic cells were counted by staining with Annexin V-Cyanine-3 (AVC3) and 7-aminoactinomycin (7AAC). AVC3-positive, 7AAC-positive, and AVC3/7AAC doubly positive cells were assigned as apoptotic, necrotic, and 2nd necrotic cells, respectively. The relative number of apoptotic and 2nd necrotic cells (N A + N A/7) to the total number of dying cells (N T) was 84 ∼ 94%, which was independent of spermine concentration in the range from 0.1 to 2.0 mM. The MMTS generation rate at the final stage, however, was dependent on the spermine concentration. It was 60 ∼ 80% in the range from 0.1 to 1.5 mM, while it decreased sharply to 1% at 2 mM. This suggests another role of spermine in the MMTS generation in addition to the induction of apoptosis. This 2nd role seems to be inhibited at a spermine concentration higher than a critical limit between 1.5 and 2.0 mM.

The turbomachine blading design using S2-S1 approach

NASA Technical Reports Server (NTRS)

Luu, T. S.; Bencherif, L.; Viney, B.; Duc, J. M. Nguyen

1991-01-01

The boundary conditions corresponding to the design problem when the blades being simulated by the bound vorticity distribution are presented. The 3D flow is analyzed by the two steps S2 - S1 approach. In the first step, the number of blades is supposed to be infinite, the vortex distribution is transformed into an axisymmetric one, so that the flow field can be analyzed in a meridional plane. The thickness distribution of the blade producing the flow channel striction is taken into account by the modification of metric tensor in the continuity equation. Using the meridional stream function to define the flow field, the mass conservation is satisfied automatically. The governing equation is deduced from the relation between the azimuthal component of the vorticity and the meridional velocity. The value of the azimuthal component of the vorticity is provided by the hub to shroud equilibrium condition. This step leads to the determination of the axisymmetric stream sheets as well as the approximate camber surface of the blade. In the second step, the finite number of blades is taken into account, the inverse problem corresponding to the blade to blade flow confined in each stream sheet is analyzed. The momentum equation implies that the free vortex of the absolute velocity must be tangential to the stream sheet. The governing equation for the blade to blade flow stream function is deduced from this condition. At the beginning, the upper and the lower surfaces of the blades are created from the camber surface obtained from the first step with the assigned thickness distribution. The bound vorticity distribution and the penetrating flux conservation applied on the presumed blade surface constitute the boundary conditions of the inverse problem. The detection of this flux leads to the rectification of the geometry of the blades.

Process of Argumentation in High School Biology Class: A Qualitative Analysis

NASA Astrophysics Data System (ADS)

Ramli, M.; Rakhmawati, E.; Hendarto, P.; Winarni

2017-02-01

Argumentation skill can be nurtured by designing a lesson in which students are provided with the opportunity to argue. This research aims to analyse argumentation process in biology class. The participants were students of three biology classes from different high schools in Surakarta Indonesia. One of the classroom was taught by a student teacher, and the rest were instructed by the assigned teachers. Through a classroom observation, oral activities were noted, audio-recorded and video-taped. Coding was done based on the existence of claiming-reasoning-evidence (CRE) process by McNeill and Krajcik. Data was analysed qualitatively focusing on the role of teachers to initiate questioning to support argumentation process. The lesson design of three were also analysed. The result shows that pedagogical skill of teachers to support argumentation process, such as skill to ask, answer, and respond to students’ question and statements need to be trained intensively. Most of the argumentation found were only claiming, without reasoning and evidence. Teachers have to change the routine of mostly posing open-ended questions to students, and giving directly a correct answer to students’ questions. Knowledge and skills to encourage student to follow inquiry-based learning have to be acquired by teachers.

Spaceport Command and Control System Support Software Development

NASA Technical Reports Server (NTRS)

Brunotte, Leonard

2016-01-01

The Spaceport Command and Control System (SCCS) is a project developed and used by NASA at Kennedy Space Center in order to control and monitor the Space Launch System (SLS) at the time of its launch. One integral subteam under SCCS is the one assigned to the development of a data set building application to be used both on the launch pad and in the Launch Control Center (LCC) at the time of launch. This web application was developed in Ruby on Rails, a web framework using the Ruby object-oriented programming language, by a 15 - employee team (approx.). Because this application is such a huge undertaking with many facets and iterations, there were a few areas in which work could be more easily organized and expedited. As an intern working with this team, I was charged with the task of writing web applications that fulfilled this need, creating a virtual and highly customizable whiteboard in order to allow engineers to keep track of build iterations and their status. Additionally, I developed a knowledge capture web application wherein any engineer or contractor within SCCS could ask a question, answer an existing question, or leave a comment on any question or answer, similar to Stack Overflow.

Emergency preparedness.

PubMed

Mahon, Christine F; Long, Carol O

2006-01-01

The Boy Scout motto is "be prepared," but can your home health agency abide by this standard? The post-9/11 days of 2001 and the natural disasters that have threatened people and plagued our home and countries abroad illustrate the heightened level of awareness and preparedness home healthcare agencies must achieve to satisfactorily meet emergency preparedness standards. Community-based nurses often are on the front line of response to a man-made, biological, or naturally occurring event. You may have been assigned to work on a plan for your agency's response or have had questions asked about preparedness by your clients and family members. Here are six Web sites to get you started on the answers to those questions and concerns.

Nuclear Data Sheets for A = 70

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gürdal, G.; McCutchan, E. A.

2016-09-01

We evaluated spectroscopic data for all nuclei with mass number A = 70, and the corresponding level schemes from radioactive decay and reaction studies are presented. Since the previous evaluation, the half-life of 70Mn has been measured and excited states in 70Fe observed for the first time. Furthermore we studied the excited states in 70Ni extensively while Coulomb excitation and collinear laser spectroscopy measurements in 70Cu have allowed for firm Jπ assignments. Despite new measurements, there remain some discrepancies in half-lives of low lying states in 70Zn. New measurements have extended the knowledge of high-spin band structures in 70Ge andmore » 70As. Our evaluation supersedes the prior A = 70 evaluation of 2004Tu09.« less

Science education: A meta-analysis of major questions

NASA Astrophysics Data System (ADS)

Anderson, Ronald D.; Kahl, Stuart R.; Glass, Gene V.; Smith, Mary Lee

A multi-institutional endeavor was initiated to integrate the findings of extant research studies directed toward the major science education research questions. The research questions were selected by a largely empirical process of identifiying the most frequently researched questions in the literature. These questions were assigned to various researchers who developed coding sheets and procedures with many features in common. This article describes the overall operation of the project, the research questions identified, and some rudiments of meta-analysis. The results of the several meta-analysis are reported in the other articles of this issue of the Journal. The final article in this issue deals with research topics for which data are drawn from one or more of the separate meta-analyses.

Molecular dynamics in aluminum layered double hydroxides as studied by 1H T1ρ NMR measurements

NASA Astrophysics Data System (ADS)

Vyalikh, Anastasia; Wang, De-Yi; Wagenknecht, Udo; Heinrich, Gert; Scheler, Ulrich

2011-06-01

Proton dynamics in pristine and organically-modified layered double hydroxide has been studied by 1H T1ρ. Inverse Laplace transform with spectral resolution results in a correlation of T1ρ and chemical shift. In LDH two contributions are resolved. They are assigned to the metal hydroxides, forming the LDH sheets (4-8 ms), and mobile interlayer water (2 ms). Apparent T1ρ values of OH-protons in surfactant-modified LDH are different in dodecylbenzenesulfonate- (SDBS) and sodium octasulfonate- (C8) modified LDH. This difference is explained by the presence of water in LDH-SDBS. The effects of spin diffusion have been studied by performing 2D 1H RFDR in the LDH-SDBS.

Improving Measures of Sexual and Gender Identity in English and Spanish to Identify LGBT Older Adults in Surveys

PubMed Central

Milesi, Carolina; Stern, Michael; Viox, Melissa Heim; Morrison, Heather; Guerino, Paul; Dragon, Christina N.; Haffer, Samuel C.

2017-01-01

Abstract Purpose: The goal of this research is to advance the study of health disparities faced by older sexual and gender minorities by assessing comprehension of and improving measures of sexual and gender identity in surveys. Methods: Cognitive interviews were conducted by expert interviewers with 48 non-lesbian, gay, bisexual, and transgender (non-LGBT) and 9 LGBT older English and Spanish speakers. Results: All respondents were able to answer questions about their sex assigned at birth and current gender identity successfully despite some cisgender respondents' lack of clear understanding of the transgender response option. On the contrary, while the vast majority of English speakers could answer the question about their sexual identity successfully, almost 60% of the non-LGBT Spanish speakers did not select the “heterosexual, that is, not gay (or lesbian)” response category. Qualitative probing of their response process pointed mainly to difficulties understanding the term “heterosexual,” leading to their choosing “something else” or saying that they didn't know how to answer. A second round of testing of alternative response categories for the sexual identity question with Spanish speakers found a marked improvement when offered “not gay (or lesbian), that is, heterosexual” instead of beginning with the term “heterosexual.” Conclusion: This research adds to our understanding of gender and sexual identity questions appropriate for population surveys with older adults. Inclusion of these measures in surveys is a crucial step in advancing insights into the needs of and disparities faced by LGBT older adults. PMID:29154714

Haemodialysis or haemodiafiltration: that is the question.

PubMed

Locatelli, Francesco; Carfagna, Fabio; Del Vecchio, Lucia; La Milia, Vincenzo

2018-04-24

Despite the technological and pharmacological advancements in the last 30 years, morbidity and mortality of dialysis patients are still astonishingly high. Today, convective treatments, such as high-flux haemodialysis (hf-HD) and haemodiafiltration (HDF), are established techniques; the online production of fresh pure dialysate has provided clinical and economic advantages. Nevertheless, the actual benefits of HDF, even with high-convective-volume treatments, are still debatable. Three recent, randomized controlled trials compared survival outcomes in prevalent patients receiving conventional HD or post-dilution HDF and reported conflicting results. The meta-analyses of the published trials were ultimately incapable of providing a clear and definitive answer on the possible beneficial effects of choosing one treatment over the other. All-cause mortality, anaemia, phosphate control and clearance of small molecules seemed to be unaffected by the treatment modality. On the other hand, cardiovascular mortality, intradialytic vascular stability and the clearance of protein-bound molecules fared better in patients treated with HDF. These results were not consistent between the studies. Thus, there is still no conclusive answer to the question that nephrologists would like to have answered: 'Which is the best treatment for my patient?' In the age of evidence-based medicine, we need strong data to support the superiority of a treatment in comparison with another, although theoretically plausible. There is the need for a well-designed clinical trial comparing outcomes for patients randomly assigned to high- or moderate-convection-volume HDF versus hf-HD to clearly prove the clinical superiority of HDF, including the effect of different infusion volumes.

Spore ornamentation of Haplosporidium pickfordi Barrow, 1961 (Haplosporidia), a parasite of freshwater snails in Michigan, USA.

PubMed

Burreson, E M

2001-01-01

Spore ornamentation is increasingly recognized as a key character for species differentiation and genus assignment in the phylum Haplosporidia. Unfortunately, spore ornamentation is known for only a small number of described species so it is difficult to assign most species to genera with any confidence. Scanning and transmission electron microscopy were used to determine the presence and morphology of spore ornamentation of Haplosporidium pickfordi collected from the digestive gland of the snail Physella parkeri in Douglas Lake, Michigan. Spores possess filaments that are derived from the spore wall and originate from two separate areas at the posterior end of the spore. When spores are first isolated from host tissue, filaments are fused into a sheet that wraps around the spore, passing under the opercular lid. These filaments gradually unravel when spores are held in water and after about 14 d most filaments project freely from the posterior end of the spore. The number of filaments could not be determined with certainty, but appears to be approximately nine. Filaments are 100 nm in diam. and up to 50 microm in length. The presence of spore wall-derived filaments confirms the placement of the parasite in the genus Haplosporidium.

Ion selection of charge-modified large nanopores in a graphene sheet

NASA Astrophysics Data System (ADS)

Zhao, Shijun; Xue, Jianming; Kang, Wei

2013-09-01

Water desalination becomes an increasingly important approach for clean water supply to meet the rapidly growing demand of population boost, industrialization, and urbanization. The main challenge in current desalination technologies lies in the reduction of energy consumption and economic costs. Here, we propose to use charged nanopores drilled in a graphene sheet as ion exchange membranes to promote the efficiency and capacity of desalination systems. Using molecular dynamics simulations, we investigate the selective ion transport behavior of electric-field-driven KCl electrolyte solution through charge modified graphene nanopores. Our results reveal that the presence of negative charges at the edge of graphene nanopore can remarkably impede the passage of Cl- while enhance the transport of K+, which is an indication of ion selectivity for electrolytes. We further demonstrate that this selectivity is dependent on the pore size and total charge number assigned at the nanopore edge. By adjusting the nanopore diameter and electric charge on the graphene nanopore, a nearly complete rejection of Cl- can be realized. The electrical resistance of nanoporous graphene, which is a key parameter to evaluate the performance of ion exchange membranes, is found two orders of magnitude lower than commercially used membranes. Our results thus suggest that graphene nanopores are promising candidates to be used in electrodialysis technology for water desalinations with a high permselectivity.

Radio-echo sounding at Dome C, East Antarctica: A comparison of measured and modeled data

NASA Astrophysics Data System (ADS)

Winter, Anna; Eisen, Olaf; Steinhage, Daniel; Zirizzotti, Achille; Urbini, Stefano; Cavitte, Marie; Blankenship, Donald D.; Wolff, Eric

2016-04-01

The internal layering architecture of ice sheets, detected with radio-echo sounding (RES), contains clues to past ice-flow dynamics and mass balance. A common way of relating the recorded travel time of RES reflections to depth is by integrating a wave-speed distribution. This results in an increasing absolute error with depth. We present a synchronization of RES-internal layers of different radar systems (Alfred Wegener Institute, Center for Remote Sensing of Ice Sheets, Istituto Nazionale di Geofisica e Vulcanologia, British Antarctic Survey and University of Texas Institute for Geophysics) with ice-core records from the Antarctic deep drill site Dome C. Synthetic radar traces are obtained from measurements of ice-core density and conductivity with a 1D model of Maxwell's equations. The reflection peaks of the different radar systems' measurements are shifted by a wiggle-matching algorithm, so they match the synthetic trace. In this way, we matched pronounced internal reflections in the RES data to conductivity peaks with considerably smaller depth uncertainties, and assigned them with the ice-core age. We examine the differences in shifts and resolution of the different RES data to address the question of their comparability and combined analysis for an extensive age-depth distribution.

Time needed to achieve completeness and accuracy in bedside lung ultrasound reporting in intensive care unit.

PubMed

Tutino, Lorenzo; Cianchi, Giovanni; Barbani, Francesco; Batacchi, Stefano; Cammelli, Rita; Peris, Adriano

2010-08-12

The use of lung ultrasound (LUS) in ICU is increasing but ultrasonographic patterns of lung are often difficult to quantify by different operators. The aim of this study was to evaluate the accuracy and quality of LUS reporting after the introduction of a standardized electronic recording sheet. Intensivists were trained for LUS following a teaching programme. From April 2008, an electronic sheet was designed and introduced in ICU database in order to uniform LUS examination reporting. A mark from 0 to 24 has been given for each exam by two senior intensivists not involved in the survey. The mark assigned was based on completeness of a precise reporting scheme, concerning the main finding of LUS. A cut off of 15 was considered sufficiency. The study comprehended 12 months of observations and a total of 637 LUS. Initially, although some improvement in the reports completeness, still the accuracy and precision of examination reporting was below 15. The time required to reach a sufficient quality was 7 months. A linear trend in physicians progress was observed. The uniformity in teaching programme and examinations reporting system permits to improve the level of completeness and accuracy of LUS reporting, helping physicians in following lung pathology evolution.

Structural effects of simvastatin on liver rate tissue: Fourier transform infrared and Raman microspectroscopic studies

NASA Astrophysics Data System (ADS)

Garip, Sebnem; Bayari, Sevgi Haman; Severcan, Mete; Abbas, Sherif; Lednev, Igor K.; Severcan, Feride

2016-02-01

Simvastatin is one of the most frequently prescribed statins because of its efficacy in the treatment of hypercholesterolemia, reducing cardiovascular risk and related mortality. Determination of its side effects on different tissues is mandatory to improve safe use of this drug. In the present study, the effects of simvastatin on molecular composition and structure of healthy rat livers were investigated by Fourier transform infrared and Raman imaging. Simvastatin-treated groups received 50 mg/kg/day simvastatin for 30 days. The ratio of the area and/or intensity of the bands assigned to lipids, proteins, and nucleic acids were calculated to get information about the drug-induced changes in tissues. Loss of unsaturation, accumulation of end products of lipid peroxidation, and alterations in lipid-to-protein ratio were observed in the treated group. Protein secondary structure studies revealed significant decrease in α-helix and increase in random coil, while native β-sheet decreases and aggregated β-sheet increases in treated group implying simvastatin-induced protein denaturation. Moreover, groups were successfully discriminated using principal component analysis. Consequently, high-dose simvastatin treatment induces hepatic lipid peroxidation and changes in molecular content and protein secondary structure, implying the risk of liver disorders in drug therapy.

Validation of science virtual test to assess 8th grade students' critical thinking on living things and environmental sustainability theme

NASA Astrophysics Data System (ADS)

Rusyati, Lilit; Firman, Harry

2017-05-01

This research was motivated by the importance of multiple-choice questions that indicate the elements and sub-elements of critical thinking and implementation of computer-based test. The method used in this research was descriptive research for profiling the validation of science virtual test to measure students' critical thinking in junior high school. The participant is junior high school students of 8th grade (14 years old) while science teacher and expert as the validators. The instrument that used as a tool to capture the necessary data are sheet of an expert judgment, sheet of legibility test, and science virtual test package in multiple choice form with four possible answers. There are four steps to validate science virtual test to measure students' critical thinking on the theme of "Living Things and Environmental Sustainability" in 7th grade Junior High School. These steps are analysis of core competence and basic competence based on curriculum 2013, expert judgment, legibility test and trial test (limited and large trial test). The test item criterion based on trial test are accepted, accepted but need revision, and rejected. The reliability of the test is α = 0.747 that categorized as `high'. It means the test instruments used is reliable and high consistency. The validity of Rxy = 0.63 means that the validity of the instrument was categorized as `high' according to interpretation value of Rxy (correlation).

Teaching Plate Tectonic Concepts using GeoMapApp Learning Activities

NASA Astrophysics Data System (ADS)

Goodwillie, A. M.; Kluge, S.

2012-12-01

GeoMapApp Learning Activities ( http://serc.carleton.edu/geomapapp/collection.html ) can help educators to expose undergraduate students to a range of earth science concepts using high-quality data sets in an easy-to-use map-based interface called GeoMapApp. GeoMapApp Learning Activities require students to interact with and analyse research-quality geoscience data as a means to explore and enhance their understanding of underlying content and concepts. Each activity is freely available through the SERC-Carleton web site and offers step-by-step student instructions and answer sheets. Also provided are annotated educator versions of the worksheets that include teaching tips, additional content and suggestions for further work. The activities can be used "off-the-shelf". Or, since the educator may require flexibility to tailor the activities, the documents are provided in Word format for easy modification. Examples of activities include one on the concept of seafloor spreading that requires students to analyse global seafloor crustal age data to calculate spreading rates in different ocean basins. Another activity has students explore hot spots using radiometric age dating of rocks along the Hawaiian-Emperor seamount chain. A third focusses upon the interactive use of contours and profiles to help students visualise 3-D topography on 2-D computer screens. A fourth activity provides a study of mass wasting as revealed through geomorphological evidence. The step-by-step instructions and guided inquiry approach reduce the need for teacher intervention whilst boosting the time that students can spend on productive exploration and learning. The activities can be used, for example, in a classroom lab with the educator present and as self-paced assignments in an out-of-class setting. GeoMapApp Learning Activities are funded through the NSF GeoEd program and are aimed at students in the introductory undergraduate, community college and high school levels. The activities are based upon GeoMapApp (http://www.geomapapp.org), a free map-based data exploration and visualisation tool that allows students to access a wide range of geoscience data in a virtual lab-like environment.

Environmental Conditions for Space Flight Hardware: A Survey

NASA Technical Reports Server (NTRS)

Plante, Jeannette; Lee, Brandon

2005-01-01

Interest in generalization of the physical environment experienced by NASA hardware from the natural Earth environment (on the launch pad), man-made environment on Earth (storage acceptance an d qualification testing), the launch environment, and the space environment, is ed to find commonality among our hardware in an effort to reduce cost and complexity. NASA is entering a period of increase in its number of planetary missions and it is important to understand how our qualification requirements will evolve with and track these new environments. Environmental conditions are described for NASA projects in several ways for the different periods of the mission life cycle. At the beginning, the mission manager defines survivability requirements based on the mission length, orbit, launch date, launch vehicle, and other factors . such as the use of reactor engines. Margins are then applied to these values (temperature extremes, vibration extremes, radiation tolerances, etc,) and a new set of conditions is generalized for design requirements. Mission assurance documents will then assign an additional margin for reliability, and a third set of values is provided for during testing. A fourth set of environmental condition values may evolve intermittently from heritage hardware that has been tested to a level beyond the actual mission requirement. These various sets of environment figures can make it quite confusing and difficult to capture common hardware environmental requirements. Environmental requirement information can be found in a wide variety of places. The most obvious is with the individual projects. We can easily get answers to questions about temperature extremes being used and radiation tolerance goals, but it is more difficult to map the answers to the process that created these requirements: for design, for qualification, and for actual environment with no margin applied. Not everyone assigned to a NASA project may have that kind of insight, as many have only the environmental requirement numbers needed to do their jobs but do not necessarily have a programmatic-level understanding of how all of the environmental requirements fit together.

Unravelling source regions of ice rafted debris within three NE Atlantic marine sediment cores during the deglacial interval: a multi-proxy approach

NASA Astrophysics Data System (ADS)

Small, David; Hibbert, Fiona; Austin, Bill

2010-05-01

Ice-rafted debris (IRD) within marine sediments of the North Atlantic provide an important archive of glacial activity on adjacent landmasses and attest to the activity of multiple calving ice margins during the last glacial cycle. IRD records therefore provide a means to reconstruct ice sheet dynamics and their interaction with the climate system, providing evidence of both the source of the ice and the location of melting (e.g. Ruddiman, 1977; Bond and Lotti, 1995). The complex interaction of the circum-Atlantic ice sheets and limitations of individual techniques often hinders firm source designations (i.e. IRD may be derived from multiple sources which cannot be differentiated by, for example, visual characterisation). Initial work identified diagnostic grain types that could be attributed to source areas of palaeo ice-sheets (eg: Bond & Lotti 1995) however, for the BIS, "diagnostic" basalt may be derived from sources to the east and west of the cores (Hibbert et al 2009, Scourse et al 2009). We therefore, utilise a multi-proxy approach to investigate the deglacial dynamics of the last British Ice Sheet (BIS) using inter alia lithic characterisation, fluxes of IRD to the core sites, magnetic susceptibility and a magnetic un-mixing model. A novel application of major element geochemistry of garnets contained within ice-rafted debris of the three high resolution marine sediment cores is presented. Garnets can be used to infer provenance (e.g. Oliver 2001) as major element composition may be assigned to specific metamorphic terranes. The IRD present within these cores is believed to be predominantly sourced from the BIS (cf: Knutz et al 2001, Hibbert et al 2009). This assertion is tested through multiple analytical techniques used and replication of records across the Hebridean shelf into the deep ocean. References • Bond, G.C. & Lotti, R., 1995. Iceberg discharges into the North Atlantic on millennial timescales during the last glaciation. Science 267. pp. 1005-1010. • Hibbert, F.D., Austin, W.E.N., Leng, M.J. and Gatliff, R.W., 2009. British Ice Sheet Dynamics inferred from North Atlantice ice-rafted debris records spanning the last 175,000 years. Journal of Quaternary Science. ISSN 0267-8179. • Knutz, P.C., Austin, W.E.N. and Jones, E.J.W., 2001. Millenial-scale depositional cycles related to British Ice Sheet variability and North Atlantic paleocirculation since 45kyr B.P., Barra Fan, U.K. margin. Paleoceanography 16. pp.53-64. • Oliver, G.J.H., 2001. Reconstruction of the Grampian episode in Scotland: it's place in the Caledonian Orogeny. Tectonphysics 332. pp.23-49. • Ruddiman, W.F., 1977. Late Quaternary deposition of ice-rafted sand in the sub-polar North Atlantic (lat 40° to 65°). Geological Society of America Bulletin 88. pp.1813-1821. • Scourse, J.D., Haapaniemi, A.I., Colmenero-Hidalgo, E., Peck, V.L., Hall, I.R., Austin, W.E.N., Knutz, P.C. and Zahn, R., 2009. Growth, dynamics and deglaciation of the last British-Irish Ice Sheet: the deep-sea ice-rafted detritus record. Quaternary Science Reviews 28. pp.3066-3084.

MGmapper: Reference based mapping and taxonomy annotation of metagenomics sequence reads

PubMed Central

Lukjancenko, Oksana; Thomsen, Martin Christen Frølund; Maddalena Sperotto, Maria; Lund, Ole; Møller Aarestrup, Frank; Sicheritz-Pontén, Thomas

2017-01-01

An increasing amount of species and gene identification studies rely on the use of next generation sequence analysis of either single isolate or metagenomics samples. Several methods are available to perform taxonomic annotations and a previous metagenomics benchmark study has shown that a vast number of false positive species annotations are a problem unless thresholds or post-processing are applied to differentiate between correct and false annotations. MGmapper is a package to process raw next generation sequence data and perform reference based sequence assignment, followed by a post-processing analysis to produce reliable taxonomy annotation at species and strain level resolution. An in-vitro bacterial mock community sample comprised of 8 genuses, 11 species and 12 strains was previously used to benchmark metagenomics classification methods. After applying a post-processing filter, we obtained 100% correct taxonomy assignments at species and genus level. A sensitivity and precision at 75% was obtained for strain level annotations. A comparison between MGmapper and Kraken at species level, shows MGmapper assigns taxonomy at species level using 84.8% of the sequence reads, compared to 70.5% for Kraken and both methods identified all species with no false positives. Extensive read count statistics are provided in plain text and excel sheets for both rejected and accepted taxonomy annotations. The use of custom databases is possible for the command-line version of MGmapper, and the complete pipeline is freely available as a bitbucked package (https://bitbucket.org/genomicepidemiology/mgmapper). A web-version (https://cge.cbs.dtu.dk/services/MGmapper) provides the basic functionality for analysis of small fastq datasets. PMID:28467460

MGmapper: Reference based mapping and taxonomy annotation of metagenomics sequence reads.

PubMed

Petersen, Thomas Nordahl; Lukjancenko, Oksana; Thomsen, Martin Christen Frølund; Maddalena Sperotto, Maria; Lund, Ole; Møller Aarestrup, Frank; Sicheritz-Pontén, Thomas

2017-01-01

An increasing amount of species and gene identification studies rely on the use of next generation sequence analysis of either single isolate or metagenomics samples. Several methods are available to perform taxonomic annotations and a previous metagenomics benchmark study has shown that a vast number of false positive species annotations are a problem unless thresholds or post-processing are applied to differentiate between correct and false annotations. MGmapper is a package to process raw next generation sequence data and perform reference based sequence assignment, followed by a post-processing analysis to produce reliable taxonomy annotation at species and strain level resolution. An in-vitro bacterial mock community sample comprised of 8 genuses, 11 species and 12 strains was previously used to benchmark metagenomics classification methods. After applying a post-processing filter, we obtained 100% correct taxonomy assignments at species and genus level. A sensitivity and precision at 75% was obtained for strain level annotations. A comparison between MGmapper and Kraken at species level, shows MGmapper assigns taxonomy at species level using 84.8% of the sequence reads, compared to 70.5% for Kraken and both methods identified all species with no false positives. Extensive read count statistics are provided in plain text and excel sheets for both rejected and accepted taxonomy annotations. The use of custom databases is possible for the command-line version of MGmapper, and the complete pipeline is freely available as a bitbucked package (https://bitbucket.org/genomicepidemiology/mgmapper). A web-version (https://cge.cbs.dtu.dk/services/MGmapper) provides the basic functionality for analysis of small fastq datasets.

Evaluation of the appropriateness and outcome of in-hospital telemetry monitoring.

PubMed

Fålun, Nina; Nordrehaug, Jan Erik; Hoff, Per Ivar; Langørgen, Jørund; Moons, Philip; Norekvål, Tone M

2013-10-15

The American Heart Association classifies monitored patients into 3 categories. The aims of this study were to (1) investigate how patients are assigned according to the American Heart Association classification, (2) determine the number and type of arrhythmic events experienced by these patients, and (3) describe subsequent changes in management. A prospective observational study design was used. All patients assigned to telemetry during a 3-month period were consecutively enrolled in our study. Data were collected 24/7. Only arrhythmias that might require a change in management were recorded. Monitor watchers at the central monitoring station completed a standard data sheet assessing 64 variables. These data, as well as medical records, were reviewed by the investigator. Overall, 1,194 patients were included. Eighteen percent of the patients were assigned to American Heart Association class I (monitoring indicated), 71% to class II (monitoring may be of benefit), and 11% to class III (monitoring not indicated). The overall arrhythmia event rate was 33%. Forty-three percent of class I patients, 28% of class II patients, and 47% of class III patients experienced arrhythmia events. Change in management occurred in 25% of class I patients, 14% of class II patients, and 29% of class III patients. Although the number of class III indications should have been reduced, nearly 1/2 of class III patients experienced arrhythmia events and 1/3 of them received management changes. This outcome challenges existing guidelines. In conclusion, most patients in this study were monitored appropriately, according to class I and II indications. Copyright © 2013 Elsevier Inc. All rights reserved.

Psychological Autopsy Studies as Diagnostic Tools: Are they Methodologically Flawed?

PubMed Central

Hjelmeland, Heidi; Dieserud, Gudrun; Dyregrov, Kari; Knizek, Birthe L.; Leenaars, Antoon A.

2012-01-01

One of the most established “truths” in suicidology is that almost all (90 % or more) of those who kill themselves suffer from one or more mental disorders, and a causal link between the two is implied. Psychological autopsy (PA) studies constitute one main evidence base for this conclusion. However, there has been little reflection on the reliability and validity of this method. For example, psychiatric diagnoses are assigned to people who have died by suicide by interviewing a few of the relatives and/or friends, often many years after the suicide. In this article, we scrutinize PA studies with particular focus on the diagnostic process and demonstrate that they cannot constitute a valid evidence base for a strong relationship between mental disorders and suicide. We show that most questions asked to assign a diagnosis are impossible to answer reliably by proxies, and thus, one cannot validly make conclusions. Thus, as a diagnostic tool psychological autopsies should now be abandoned. Instead, we recommend qualitative approaches focusing on the understanding of suicide beyond mental disorders, where narratives from a relatively high number of informants around each suicide are systematically analyzed in terms of the informants’ relationships with the deceased. PMID:24563941

The STRENGTH Ezine: an application of e-mail for health promotion in adolescent girls.

PubMed

Abroms, Lorien C; Fagan, Pebbles; Eisenberg, Marla E; Lee, Hye-Seung H; Remba, Natania; Sorensen, Glorian

2004-01-01

Few studies have investigated the efficacy of e-mail for promoting behavior change. This study evaluates the participation in and outcomes associated with an e-mail-based health promotion program. Adolescent girls aged 15 to 17 years were recruited at a shopping mall. Participants with an e-mail address were assigned to the interactive e-mail magazine (Ezine) group (n = 37), whereas those not reporting an e-mail address were assigned to the non-Ezine group (n = 33). Participants in the Ezine group received the health Ezine, which included a quiz and an advice column, on a weekly basis. Results indicate that among the Ezine group, there was a high recall of the Ezine (81.1%), and more than one third of the participants replied to Ezine volumes with quiz answers or an advice question (36.6%). Differences in health behavior change between the Ezine and non-Ezine groups were not significant. E-mails on health-related matters can generate moderate levels of involvement in adolescent girls. Given the widespread use of e-mail, more studies are needed on the effective application of e-mail for health behavior change.

Nuclear Data Sheets for A = 70

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gürdal, G.; McCutchan, E.A.

2016-09-15

Spectroscopic data for all nuclei with mass number A = 70 have been evaluated, and the corresponding level schemes from radioactive decay and reaction studies are presented. Since the previous evaluation, the half-life of {sup 70}Mn has been measured and excited states in {sup 70}Fe observed for the first time. Excited states in {sup 70}Ni have been more extensively studied while Coulomb excitation and collinear laser spectroscopy measurements in {sup 70}Cu have allowed for firm Jπ assignments. Despite new measurements, there remain some discrepancies in half-lives of low lying states in {sup 70}Zn. New measurements have extended the knowledge ofmore » high-spin band structures in {sup 70}Ge and {sup 70}As. This evaluation supersedes the prior A = 70 evaluation of 2004Tu09.« less

Nuclear Data Sheets for A=241

DOE PAGES

Nesaraja, Caroline D.

2015-11-27

This paper presents available information pertaining to the nuclear structure of ground and excited states for all known nuclei with mass numbers A=24, which have been compiled and evaluated. The adopted level and decay schemes, as well as the detailed nuclear properties and configuration assignments based on experimental data are presented for these nuclides. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 ( 241Np, 241Pu,more » 241Am, 241Cm, 241Bk, and 241Cf), 2011Me01 (241Es), and 2013Th02 ( 241Fm).« less

STS-89 M.S. Sharipov of the RSA participates in TCDT

NASA Technical Reports Server (NTRS)

1998-01-01

STS-89 Mission Specialist Salizhan Sharipov of the Russian Space Agency participates in a question and answer session for the media during Terminal Countdown Demonstration Test (TCDT) activities at KSC. The seven astronauts assigned to the eighth Shuttle-Mir docking flight are at KSC for this dress rehearsal for launch, which includes emergency egress training at the launch pad and culminates with a simulated countdown. The Space Shuttle Endeavour is undergoing preparations for liftoff, scheduled for Jan. 22. STS-89 Mission Specialist Andrew Thomas, Ph.D, will transfer to the Russian Space Station Mir, and succeed David Wolf, M.D., who will return to Earth aboard Endeavour. Dr. Thomas will live and work on Mir until June.

Students' understanding of direct current resistive electrical circuits

NASA Astrophysics Data System (ADS)

Engelhardt, Paula Vetter; Beichner, Robert J.

2004-01-01

Both high school and university students' reasoning regarding direct current resistive electric circuits often differ from the accepted explanations. At present, there are no standard diagnostic tests on electric circuits. Two versions of a diagnostic instrument were developed, each consisting of 29 questions. The information provided by this test can provide instructors with a way of evaluating the progress and conceptual difficulties of their students. The analysis indicates that students, especially females, tend to hold multiple misconceptions, even after instruction. During interviews, the idea that the battery is a constant source of current was used most often in answering the questions. Students tended to focus on the current in solving problems and to confuse terms, often assigning the properties of current to voltage and/or resistance.

Just-in-Time Teaching Exercises to Engage Students in an Introductory-Level Dinosaur Course

NASA Astrophysics Data System (ADS)

Guertin, Laura A.; Zappe, Sarah E.; Kim, Heeyoung

2007-12-01

The Just-in-Time Teaching (JiTT) technique allows students to be engaged in course material outside of the classroom by answering web-based questions. The responses are summarized and presented to students in class with a follow-up active learning exercise. College students enrolled in an introductory-level general education geoscience course were surveyed over a two-semester period on their engagement level during lecture and perceived learning of course content. Data show that students are able to reflect on their prior knowledge and construct new knowledge with weekly graded JiTT exercises. Despite increasing and competing pressures outside of the classroom, students reported increased learning and engagement in a course with required weekly assignments.

Radiation risks knowledge in resident and fellow in paediatrics: a questionnaire survey.

PubMed

Salerno, Sergio; Marchese, Paola; Magistrelli, Andrea; Tomà, Paolo; Matranga, Domenica; Midiri, Massimo; Ugazio, Alberto G; Corsello, Giovanni

2015-03-22

Analyse through a multi-choice anonymous questionnaire the knowledge's level in paediatric residents and fellows in two different main Italian hospital, looking mainly to the information to patients and relatives related to risks of ionizing radiation used in common radiological investigations in children. 65 multi choice questionnaires were distributed to paediatric residents and fellows of two different hospitals, an University Hospital (A.O.U.P. "P. Giaccone"- University of Palermo) and a national reference centre for paediatrics (Ospedale Pediatrico Bambino Gesù - Rome). The questionnaire included twelve multiple-choice questions with the aim of analyzing the knowledge about ionizing radiation related risks in infants and children who undergo common diagnostic radiology investigations. The data obtained were processed using software Stata/MP version 11.2. In order to measure the level of expertise of each interviewee a binary indicator was built. The value 1 was assigned if the percentage of correct answers exceeds the median of the distribution and 0 for values not exceeding the median. The association between the level of competence and demographic characteristics (gender, age) and training experience was measured by means of α(2) test. 51/65 questionnaires were completed, returned and analysed (87.7%). Only 18 surveyed (35%), (95% IC = [22%-48%]) can be defined as competent in radiation risk knowledge for common radiological investigations, considering the percentage of correct answers at least of 50% (sufficient knowledge was given with a minimum score of 8 correct answers out of 12). The study demonstrates an urgent need to implement the radiation protection knowledge in the training programme of paediatricians, that improve if just a short targeted training is performed.

How to Avoid Stereotypes? Evaluation of a Strategy based on Self-Regulatory Processes.

PubMed

Aranda, María; Montes-Berges, Beatriz

2016-06-10

Based on research on the motivational processes involved in preventing and controlling stereotypes, we aimed to assess whether temporary activation of egalitarian goals - by means of a task that gives respondents exposure to a text on gender inequality - can prevent stereotyped answers on the task. The task asks participants to place women and men into a hierarchical organizational structure. Two specific objectives were established: first, to control the effect of prejudice and egalitarian commitment on the dependent variable; and second, to study gender differences in task responses. The study included 474 college students, 153 men and 321 women. Their mean age was 20.04 (SD = 4.43). ANCOVA indicated main effects of condition, F(1) = 4.15, p = .042, η2 = .081 (control condition without goal activation vs. experimental condition with goal activation) and sex, F(1) = 40.46, p < .001, η2 = .081, on the dependent variable (female candidates placed in the chart). Specifically, responses from participants in the experimental condition avoided stereotyped answers more than participants in the control condition. Furthermore, women's performance on the task was more egalitarian than men's. Finally, there was a significant interaction effect of condition and type of organization, F(2) = 3.97, p = .019, η2 = .017; participants assigning candidates to the feminized organization differed the most across conditions.

A multi-instructor, team-based, active-learning exercise to integrate basic and clinical sciences content.

PubMed

Kolluru, Srikanth; Roesch, Darren M; Akhtar de la Fuente, Ayesha

2012-03-12

To introduce a multiple-instructor, team-based, active-learning exercise to promote the integration of basic sciences (pathophysiology, pharmacology, and medicinal chemistry) and clinical sciences in a doctor of pharmacy curriculum. A team-based learning activity that involved pre-class reading assignments, individual-and team-answered multiple-choice questions, and evaluation and discussion of a clinical case, was designed, implemented, and moderated by 3 faculty members from the pharmaceutical sciences and pharmacy practice departments. Student performance was assessed using a multiple-choice examination, an individual readiness assurance test (IRAT), a team readiness assurance test (TRAT), and a subjective, objective, assessment, and plan (SOAP) note. Student attitudes were assessed using a pre- and post-exercise survey instrument. Students' understanding of possible correct treatment strategies for depression improved. Students were appreciative of this true integration of basic sciences knowledge in a pharmacotherapy course and to have faculty members from both disciplines present to answer questions. Mean student score on the on depression module for the examination was 80.4%, indicating mastery of the content. An exercise led by multiple instructors improved student perceptions of the importance of team-based teaching. Integrated teaching and learning may be achieved when instructors from multiple disciplines work together in the classroom using proven team-based, active-learning exercises.

Anxiety and performance of nursing students in regard to assessment via clinical simulations in the classroom versus filmed assessments.

PubMed

de Souza Teixeira, Carla Regina; Kusumota, Luciana; Alves Pereira, Marta Cristiane; Merizio Martins Braga, Fernanda Titareli; Pirani Gaioso, Vanessa; Mara Zamarioli, Cristina; Campos de Carvalho, Emilia

2014-01-01

To compare the level of anxiety and performance of nursing students when performing a clinical simulation through the traditional method of assessment with the presence of an evaluator and through a filmed assessment without the presence of an evaluator. Controlled trial with the participation of Brazilian public university 20 students who were randomly assigned to one of two groups: a) assessment through the traditional method with the presence of an evaluator; or b) filmed assessment. The level of anxiety was assessed using the Zung test and performance was measured based on the number of correct answers. Averages of 32 and 27 were obtained on the anxiety scale by the group assessed through the traditional method before and after the simulation, respectively, while the filmed group obtained averages of 33 and 26; the final scores correspond to mild anxiety. Even though there was a statistically significant reduction in the intra-groups scores before and after the simulation, there was no difference between the groups. As for the performance assessments in the clinical simulation, the groups obtained similar percentages of correct answers (83% in the traditional assessment and 84% in the filmed assessment) without statistically significant differences. Filming can be used and encouraged as a strategy to assess nursing undergraduate students.

Enhancing children's vegetable consumption using vegetable-promoting picture books. The impact of interactive shared reading and character-product congruence.

PubMed

de Droog, Simone M; Buijzen, Moniek; Valkenburg, Patti M

2014-02-01

The present study investigated whether and how a picture book promoting carrots can increase young children's carrot consumption. One hundred and four children (aged 4-6years) participated in shared reading sessions using the book on five consecutive days in school. These children were assigned randomly to one of four experimental conditions. In a 2×2 between-subjects design, the reading style and character in the book were manipulated. The reading style was either passive (listening to the story) or interactive (also answering questions about the story). The character in the book fitted either conceptually well with carrots (a rabbit) or not (a turtle). Compared to a baseline group of 56 children who were not exposed to the book, the children in the experimental groups consumed almost twice as much carrots (in proportion to other foods consumed), F(1,159)=7.08, p<.01. Results suggest that picture books are particularly effective when children are actively involved, answering questions about the story. Young children seem to enjoy this interactive shared reading style, triggering positive feelings that increase children's liking and consumption of the healthy food promoted in the book. Copyright © 2013 Elsevier Ltd. All rights reserved.

Vibronic eigenstates and the geometric phase effect in the 2E″ state of NO3.

PubMed

Eisfeld, Wolfgang; Viel, Alexandra

2017-01-21

The 2 E″ state of NO 3 , a prototype for the Jahn-Teller effect, has been an enigma and a challenge for a long time for both experiment and theory. We present a detailed theoretical study of the vibronic quantum dynamics in this electronic state, uncovering the effects of tunnelling, geometric phase, and symmetry. To this end, 45 vibronic levels of NO 3 in the 2 E″ state are determined accurately and analyzed thoroughly. The computation is based on a high quality diabatic potential representation of the two-sheeted surface of the 2 E″ state developed by us [W. Eisfeld et al., J. Chem. Phys. 140, 224109 (2014)] and on the multi-configuration time dependent Hartree approach. The vibrational eigenstates of the NO 3 - anion are determined and analyzed as well to gain a deeper understanding of the symmetry properties of such D 3h symmetric systems. To this end, 61 eigenstates of the NO 3 - anion ground state are computed using the single sheeted potential surface of the 1 A 1 state published in the same reference quoted above. The assignments of both the vibrational and vibronic levels are discussed. A simple model is proposed to rationalize the computed NO 3 spectrum strongly influenced by the Jahn-Teller couplings, the associated geometric phase effect, and the tunnelling. Comparison with the available spectroscopic data is also presented.

β-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR

PubMed Central

Vasa, Suresh; Lin, Lin; Shi, Chaowei; Habenstein, Birgit; Riedel, Dietmar; Kühn, Juliane; Thanbichler, Martin; Lange, Adam

2015-01-01

Bactofilins are a widespread class of bacterial filament-forming proteins, which serve as cytoskeletal scaffolds in various cellular pathways. They are characterized by a conserved architecture, featuring a central conserved domain (DUF583) that is flanked by variable terminal regions. Here, we present a detailed investigation of bactofilin filaments from Caulobacter crescentus by high-resolution solid-state NMR spectroscopy. De novo sequential resonance assignments were obtained for residues Ala39 to Phe137, spanning the conserved DUF583 domain. Analysis of the secondary chemical shifts shows that this core region adopts predominantly β-sheet secondary structure. Mutational studies of conserved hydrophobic residues located in the identified β-strand segments suggest that bactofilin folding and polymerization is mediated by an extensive and redundant network of hydrophobic interactions, consistent with the high intrinsic stability of bactofilin polymers. Transmission electron microscopy revealed a propensity of bactofilin to form filament bundles as well as sheet-like, 2D crystalline assemblies, which may represent the supramolecular arrangement of bactofilin in the native context. Based on the diffraction pattern of these 2D crystalline assemblies, scanning transmission electron microscopy measurements of the mass per length of BacA filaments, and the distribution of β-strand segments identified by solid-state NMR, we propose that the DUF583 domain adopts a β-helical architecture, in which 18 β-strand segments are arranged in six consecutive windings of a β-helix. PMID:25550503

β-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR.

PubMed

Vasa, Suresh; Lin, Lin; Shi, Chaowei; Habenstein, Birgit; Riedel, Dietmar; Kühn, Juliane; Thanbichler, Martin; Lange, Adam

2015-01-13

Bactofilins are a widespread class of bacterial filament-forming proteins, which serve as cytoskeletal scaffolds in various cellular pathways. They are characterized by a conserved architecture, featuring a central conserved domain (DUF583) that is flanked by variable terminal regions. Here, we present a detailed investigation of bactofilin filaments from Caulobacter crescentus by high-resolution solid-state NMR spectroscopy. De novo sequential resonance assignments were obtained for residues Ala39 to Phe137, spanning the conserved DUF583 domain. Analysis of the secondary chemical shifts shows that this core region adopts predominantly β-sheet secondary structure. Mutational studies of conserved hydrophobic residues located in the identified β-strand segments suggest that bactofilin folding and polymerization is mediated by an extensive and redundant network of hydrophobic interactions, consistent with the high intrinsic stability of bactofilin polymers. Transmission electron microscopy revealed a propensity of bactofilin to form filament bundles as well as sheet-like, 2D crystalline assemblies, which may represent the supramolecular arrangement of bactofilin in the native context. Based on the diffraction pattern of these 2D crystalline assemblies, scanning transmission electron microscopy measurements of the mass per length of BacA filaments, and the distribution of β-strand segments identified by solid-state NMR, we propose that the DUF583 domain adopts a β-helical architecture, in which 18 β-strand segments are arranged in six consecutive windings of a β-helix.

Enabling parents who smoke to prevent their children from initiating smoking: results from a 3-year intervention evaluation.

PubMed

Jackson, Christine; Dickinson, Denise

2006-01-01

To evaluate effects of a home-based antismoking socialization program on the initiation of smoking among children whose parents smoke. Three-year randomized controlled trial. Parents who were current smokers and had a child in the third grade who had not tried smoking were eligible; 873 parents-offspring pairs met these criteria, completed baseline interviews, and were randomly assigned to the intervention or control condition; 776 children (89%) completed an interview 3 years after baseline and were included in the study. During 3 months, the intervention group (n = 371) received 5 printed activity guides, parenting tip sheets, child newsletters, and incentives; this group also received a booster activity guide 1 year later. The control group (n = 405) received fact sheets about smoking. Initiation of smoking (first instance of puffing on a cigarette) was reported by 12% vs 19% of children in the intervention vs control groups. Logistic regression analysis indicated that children in the control condition had twice the odds of reporting initiation of smoking as children in the intervention condition (adjusted odds ratio, 2.16; P<.001), after adjusting for child sex, parent sex, parent race, parent educational achievement, child's best friends' smoking, parent smoking rate at baseline, and parent cessation status. Children in the pre-initiation phase of smoking who receive antismoking socialization from their parents are less likely to initiate smoking, even if their parents smoke.

X-ray crystal structure of the passenger domain of plasmid encoded toxin(Pet), an autotransporter enterotoxin from enteroaggregative Escherichia coli (EAEC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Domingo Meza-Aguilar, J.; Laboratorio de Patogenicidad Bacteriana, Unidad de Hemato Oncología e Investigación, Hospital Infantil de México Federico Gómez 06720, D.F.; Fromme, Petra

Highlights: • X-ray crystal structure of the passenger domain of Plasmid encoded toxin at 2.3 Å. • Structural differences between Pet passenger domain and EspP protein are described. • High flexibility of the C-terminal beta helix is structurally assigned. - Abstract: Autotransporters (ATs) represent a superfamily of proteins produced by a variety of pathogenic bacteria, which include the pathogenic groups of Escherichia coli (E. coli) associated with gastrointestinal and urinary tract infections. We present the first X-ray structure of the passenger domain from the Plasmid-encoded toxin (Pet) a 100 kDa protein at 2.3 Å resolution which is a cause ofmore » acute diarrhea in both developing and industrialized countries. Pet is a cytoskeleton-altering toxin that induces loss of actin stress fibers. While Pet (pdb code: 4OM9) shows only a sequence identity of 50% compared to the closest related protein sequence, extracellular serine protease plasmid (EspP) the structural features of both proteins are conserved. A closer structural look reveals that Pet contains a β-pleaded sheet at the sequence region of residues 181–190, the corresponding structural domain in EspP consists of a coiled loop. Secondary, the Pet passenger domain features a more pronounced beta sheet between residues 135 and 143 compared to the structure of EspP.« less

Acceptability of unsupervised HPV self-sampling using written instructions.

PubMed

Waller, J; McCaffery, K; Forrest, S; Szarewski, A; Cadman, L; Austin, J; Wardle, J

2006-01-01

The study measured the acceptability of self-sampling for human papillomavirus (HPV) testing in the context of cervical cancer screening. Women carried out self-sampling unsupervised, using a written instruction sheet. Participants were women attending either a family planning clinic or a primary care trust for routine cervical screening. Women (n = 902) carried out self-sampling for HPV testing and then a clinician did a routine cervical smear and HPV test. Immediately after having the two tests, participants completed a measure of acceptability for both tests, and answered questions about ease of using the instruction sheet and willingness to use self-sampling in the future. The majority of women found self-sampling more acceptable than the clinician-administered test, but there was a lack of confidence that the test had been done correctly. Significant demographic differences in attitudes were found, with married women having more favourable attitudes towards self-sampling than single women, and Asian women having more negative attitudes than women in other ethnic groups. Intention to use self-sampling in the future was very high across all demographic groups. Self-sampling for HPV testing was highly acceptable in this large and demographically diverse sample, and women were able to carry out the test alone, using simple written instructions. Consistent with previous studies, women were concerned about doing the test properly and this issue will need to be addressed if self-sampling is introduced. More work is needed to see whether the demographic differences we found are robust and to identify reasons for lower acceptability among single women and those from Asian background.

Hematite, pyroxene, and phyllosilicates on Mars: Implications from oxidized impact melt rocks from Manicouagan Crater, Quebec, Canada

NASA Technical Reports Server (NTRS)

Morris, Richard V.; Golden, D. C.; Bell, James F., III; Lauer, H. V., Jr.

1995-01-01

Visible and near-IR reflectivity, Mossbauer, and X ray diffraction data were obtained on powders of impact melt rock from the Manicouagan Impact Crater located in Quebec, Canada. The iron mineralogy is dominated by pyroxene for the least oxidized samples and by hematite for the most oxidized samples. Phyllosilicate (smectite) contents up to 15 wt % were found in some heavily oxidized samples. Nanophase hematite and/or paramagnetic ferric iron is observed in all samples. No hydrous ferric oxides (e.g., goethite, lepidocrocite, and ferrihydrite) were detected, which implies the alteration occurred above 250 C. Oxidative alteration is thought to have occurred predominantly during late-stage crystallization and subsolidus cooling of the impact melt by invasion of oxidizing vapors and/or solutions while the impact melt rocks were still hot. The near-IR band minimum correlated with the extent of aleration (Fe(3+)/Fe(sub tot)) and ranged from approx. 1000 nm (high-Ca pyroxene) to approx. 850 nm (bulk, well-crystalline hematite) for least and most oxidized samples, respectively. Intermediate band positions (900-920 nm) are attributed to low-Ca pyroxene and/or a composite band from hematite-pyroxene assemblages. Manicouagan data are consistent with previous assignments of hematite and pyroxene to the 850 and 1000 nm bands observed in Martian reflectivity spectra. Manicouagan data also show that possible assignments for intermediate band positions (900-920 nm) in Martian spectra are pyroxene and/or hematite-pyroxene assemblages. By analogy with impact melt sheets and in agreement with observables for Mars, oxidative alteration of Martian impact melt sheets above 250 C and subsequent erosion could produce rocks and soils with variable proportions of hematite (both bulk and nanophase), pyroxene, and phyllosilicates as iron-bearing mineralogies. If this process is dominant, these phases on Mars were formed rapidly at relatively high temperatures on a sporadic basis throughout the history of the planet. The Manicouagan samples also show that this mineralogical diversity can be accomplished at constant chemical composition, which is also indicated for Mars from analyses of soil at the two Viking landing sites.

Hematite, pyroxene, and phyllosilicates on Mars: Implications from oxidized impact melt rocks from Manicouagan Crater, Quebec, Canada

NASA Technical Reports Server (NTRS)

Morris, Richard V.; Golden, D. C.; Bell, James F., III; Lauer, H. V., Jr.

1995-01-01

Visible and near-IR refectivity, Moessbauer, and X ray diffraction data were obtained on powders of impact melt rock from the Manicouagan Impact Crater located in Quebec, Canada. The iron mineralogy is dominated by pyroxene for the least oxidized samples and by hematite for the most oxidized samples. Phyllosilicate (smectite) contents up to approximately 15 wt % were found in some heavily oxidized samples. Nanophase hematite and/or paramagnetic ferric iron is observed in all samples. No hydrous ferric oxides (e.g., goethite, lepidocrocite, and ferrihydrite) were detected, which implies the alteration occurred above 250 C. Oxidative alteration is thought to have occurred predominantly during late-stage crystallization and subsolidus cooling of the impact melt by invasion of oxidizing vapors and/or solutions while the impact melt rocks were still hot. The near-IR band minimum correlated with the extent of aleration Fe(3+)/Fe(sub tot) and ranged from approximately 1000 nm (high-Ca pyroxene) to approximately 850 nm (bulk, well-crystalline hematite) for least and most oxidized samples, respectively. Intermediate band positions (900-920 nm) are attributed to low-Ca pyroxene and/or a composite band from hematite-pyroxene assemblages. Manicouagan data are consistent with previous assignments of hematite and pyroxene to the approximately 850 and approximately 1000nm bands observed in Martian reflectivity spectra. Manicouagan data also show that possible assignments for intermediate band positions (900-920 nm) in Martian spectra are pyroxene and/or hematite-pyroxene assemblages. By analogy with impact melt sheets and in agreement with observables for Mars, oxidative alteration of Martian impact melt sheets above 250 C and subsequent erosion could produce rocks and soils with variable proportions of hematite (both bulk and nanophase), pyroxene, and phyllosilicates as iron-bearing mineralogies. If this process is dominant, these phases on Mars were formed rapidly at relativly high temperatures on a sporadic basis throughout the history of the planet. The Manicouagan samples also show that this mineralogical diversity can be accomplished at constant chemical composition, which is also indicated for Mars from the analyses of soil at the two Viking landing sites.

KSC-2012-2294

NASA Image and Video Library

2012-04-16

CAPE CANAVERAL, Fla. – At the Shuttle Landing Facility at NASA’s Kennedy Space Center in Florida, no weather constraints to the planned flight plan are detected for departure tomorrow morning of the Shuttle Carrier Aircraft with space shuttle Discovery secured to its back. In the distance, at right, is the mate/demate device used to lift Discovery onto the aircraft. The device, also known as the MDD, is a large gantry-like steel structure used to hoist a shuttle off the ground and position it onto the back of the aircraft, or SCA. The SCA is a Boeing 747 jet, originally manufactured for commercial use, which was modified by NASA to transport the shuttles between destinations on Earth. The SCA designated NASA 905 is assigned to the remaining ferry missions, delivering the shuttles to their permanent public display sites. NASA 905 is scheduled to ferry Discovery to the Washington Dulles International Airport in Virginia on April 17, after which the shuttle will be placed on display in the Smithsonian's National Air and Space Museum Steven F. Udvar-Hazy Center. For more information on the SCA, visit http://www.nasa.gov/centers/dryden/news/FactSheets/FS-013-DFRC.html. For more information on shuttle transition and retirement activities, visit http://www.nasa.gov/transition. Photo credit: NASA/Tim Jacobs The aircraft, also known as an SCA, is a Boeing 747 jet, originally manufactured for commercial use, which was modified by NASA to transport the shuttles between destinations on Earth. The SCA designated NASA 905 is assigned to the remaining ferry missions, delivering the shuttles to their permanent public display sites. NASA 905 is scheduled to ferry Discovery to the Washington Dulles International Airport in Virginia on April 17, after which the shuttle will be placed on display in the Smithsonian's National Air and Space Museum Steven F. Udvar-Hazy Center. For more information on the SCA, visit http://www.nasa.gov/centers/dryden/news/FactSheets/FS-013-DFRC.html. For more information on shuttle transition and retirement activities, visit http://www.nasa.gov/transition. Photo credit: NASA/Tim Jacobs

Composite biaxially textured substrates using ultrasonic consolidation

DOEpatents

Blue, Craig A; Goyal, Amit

2013-04-23

A method of forming a composite sheet includes disposing an untextured metal or alloy first sheet in contact with a second sheet in an aligned opposing position; bonding the first sheet to the second sheet by applying an oscillating ultrasonic force to at least one of the first sheet and the second sheet to form an untextured intermediate composite sheet; and annealing the untextured intermediate composite sheet at a temperature lower than a primary re-crystallization temperature of the second sheet and higher than a primary re-crystallization temperature of the first sheet to convert the untextured first sheet into a cube textured sheet, wherein the cube texture is characterized by a .phi.-scan having a FWHM of no more than 15.degree. in all directions, the second sheet remaining untextured, to form a composite sheet.

Computer printing and filing of microbiology reports. 2. Evaluation and comparison with a manual system, and comparison of two manual systems.

PubMed Central

Goodwin, C S

1976-01-01

A manual system of microbiology reporting with a National Cash Register (NCR) form with printed names of bacteria and antiboitics required less time to compose reports than a previous manual system that involved rubber stamps and handwriting on plain report sheets. The NCR report cost 10-28 pence and, compared with a computer system, it had the advantages of simplicity and familarity, and reports were not delayed by machine breakdown, operator error, or data being incorrectly submitted. A computer reporting system for microbiology resulted in more accurate reports costing 17-97 pence each, faster and more accurate filing and recall of reports, and a greater range of analyses of reports that was valued particularly by the control-of-infection staff. Composition of computer-readable reports by technicians on Port-a-punch cards took longer than composing NCR reports. Enquiries for past results were more quickly answered from computer printouts of reports and a day book in alphabetical order. PMID:939810

Analysis of Work Design in Rubber Processing Plant

NASA Astrophysics Data System (ADS)

Wahyuni, Dini; Nasution, Harmein; Budiman, Irwan; Wijaya, Khairini

2018-02-01

The work design illustrates how structured jobs, tasks, and roles are defined and modified and their impact on individuals, groups, and organizations. If the work is not designed well, the company must pay greater costs for workers' health, longer production processes or even penalties for not being able to meet the delivery schedule. This is visible to the condition in a rubber processing factory in North Sumatra. Work design aspects such as layouts, machinery and equipment, worker's physical working environment, work methods, and organizational policies have not been well-organized. Coagulum grinding machines into sheets are often damaged, resulting in 4 times the delay of product delivery in 2016, the presence of complaints of heat exposure submitted by workers, and workstation that has not been properly arranged is an indication of the need for work design. The research data will be collected through field observation, and distribution of questionnaires related aspects of work design. The result of the analysis depends on the respondent's answer from the distributed questionnaire regarding the 6 aspects studied.

[Writing and publication of a clinical case report].

PubMed

Târcoveanu, E; Roca, M; Mihăescu, T

2011-01-01

A case report represents a collection of detailed information about an individual patient, written with the purpose to disseminate clinical outcomes, not previously reported. Case reports provide a rich resource for teaching and research in medicine. Despite the limitation of case reports, these are useful to generate new hypothesis for future large scale clinical trials. A clinical case report should be well structured and convey a clear message. Elements of a case report are similar to all forms of medical scientific articles: title, structured abstract, introduction, case report, discussion, conclusion and references. A well written case report with literature support and a detailed description of management of the case has the greatest chances to be published. "Uniform Requirements for Manuscripts to Biomedical Journals" form the basis for most journal instructions regarding content and formatting and should be consulted when journal's instructions don't answer to author's questions. In this paper we present a case report check sheet to use as a form of self-evaluation, prior to submitting the articles.

Technology-Enhanced Formative Assessment of Plant Identification

NASA Astrophysics Data System (ADS)

Conejo, Ricardo; Garcia-Viñas, Juan Ignacio; Gastón, Aitor; Barros, Beatriz

2016-04-01

Developing plant identification skills is an important part of the curriculum of any botany course in higher education. Frequent practice with dried and fresh plants is necessary to recognize the diversity of forms, states, and details that a species can present. We have developed a web-based assessment system for mobile devices that is able to pose appropriate questions according to the location of the student. A student's location can be obtained using the device position or by scanning a QR code attached to a dried plant sheet in a herbarium or to a fresh plant in an arboretum. The assessment questions are complemented with elaborated feedback that, according to the students' responses, provides indications of possible mistakes and correct answers. Three experiments were designed to measure the effectiveness of the formative assessment using dried and fresh plants. Three questionnaires were used to evaluate the system performance from the students' perspective. The results clearly indicate that formative assessment is objectively effective compared to traditional methods and that the students' attitudes towards the system were very positive.

A Comparison of Audio Computer-Assisted Self-Interviews to Face-to-Face Interviews of Sexual Behavior Among Perinatally HIV-Exposed Youth

PubMed Central

Marhefka, Stephanie L.; Santamaria, E. Karina; Leu, Cheng-Shiun; Brackis-Cott, Elizabeth; Mellins, Claude Ann

2013-01-01

Computer-assisted interview methods are increasingly popular in the assessment of sensitive behaviors (e.g., substance abuse and sexual behaviors). It has been suggested that the effect of social desirability is diminished when answering via computer, as compared to an interviewer-administered face-to-face (FTF) interview, although studies exploring this hypothesis among adolescents are rare and yield inconsistent findings. This study compared two interview modes among a sample of urban, ethnic-minority, perinatally HIV-exposed U.S. youth (baseline = 148 HIV+, 126 HIV−, ages 9–16 years; follow-up = 120 HIV+, 110 HIV−, ages 10–19 years). Participants were randomly assigned to receive a sexual behavior interview via either Audio Computer-Assisted Self-Interview (ACASI) or FTF interview. The prevalence of several sexual behaviors and participants’ reactions to the interviews were compared. Although higher rates of sexual behaviors were typically reported in the ACASI condition, the differences rarely reached statistical significance, even when limited to demographic subgroups—except for gender. Boys were significantly more likely to report several sexual behaviors in the ACASI condition compared to FTF, whereas among girls no significant differences were found between the two conditions. ACASI-assigned youth rated the interview process as easier and more enjoyable than did FTF-assigned youth, and this was fairly consistent across subgroup analyses as well. We conclude that these more positive reactions to the ACASI interview give that methodology a slight advantage, and boys may disclose more sexual behavior when using computer-assisted interviews. PMID:21604065

A comparison of audio computer-assisted self-interviews to face-to-face interviews of sexual behavior among perinatally HIV-exposed youth.

PubMed

Dolezal, Curtis; Marhefka, Stephanie L; Santamaria, E Karina; Leu, Cheng-Shiun; Brackis-Cott, Elizabeth; Mellins, Claude Ann

2012-04-01

Computer-assisted interview methods are increasingly popular in the assessment of sensitive behaviors (e.g., substance abuse and sexual behaviors). It has been suggested that the effect of social desirability is diminished when answering via computer, as compared to an interviewer-administered face-to-face (FTF) interview, although studies exploring this hypothesis among adolescents are rare and yield inconsistent findings. This study compared two interview modes among a sample of urban, ethnic-minority, perinatally HIV-exposed U.S. youth (baseline = 148 HIV+, 126 HIV-, ages 9-16 years; follow-up = 120 HIV+, 110 HIV-, ages 10-19 years). Participants were randomly assigned to receive a sexual behavior interview via either Audio Computer-Assisted Self-Interview (ACASI) or FTF interview. The prevalence of several sexual behaviors and participants' reactions to the interviews were compared. Although higher rates of sexual behaviors were typically reported in the ACASI condition, the differences rarely reached statistical significance, even when limited to demographic subgroups--except for gender. Boys were significantly more likely to report several sexual behaviors in the ACASI condition compared to FTF, whereas among girls no significant differences were found between the two conditions. ACASI-assigned youth rated the interview process as easier and more enjoyable than did FTF-assigned youth, and this was fairly consistent across subgroup analyses as well. We conclude that these more positive reactions to the ACASI interview give that methodology a slight advantage, and boys may disclose more sexual behavior when using computer-assisted interviews.

Assessment of the variation in American Society of Anesthesiologists [corrected] Physical Status Classification assignment in small animal anaesthesia.

PubMed

McMillan, Matthew; Brearley, Jacqueline

2013-05-01

To evaluate the interobserver variability in the assignment of the American Society of Anesthesiologists Physical Status Classification (ASA-PSC) to compromised small animal patients amongst a group of veterinary anaesthetists. Anonymous internet survey. Hypothetical case presentations. Sixteen hypothetical small animal cases with differing degrees of physiological or patho-physiological compromise were presented as part of an internet survey. Respondents were asked to assign a single ASA-PSC to each case and also to answer a number of demographic questions. ASA-PSC scores were considered separately and then grouped as scores of I-II and III-V. Agreement was analysed using the modified kappa statistic for multiple observers. Data were then sorted into various demographic groups for further analysis. There were 144 respondents of which 60 (~42%) were anaesthesia diplomates, 24 (~17%) were post-residency (nondiploma holders), 24 (~17%) were current anaesthesia residents, 21 (~15%) were general practitioners, 12 (~8%) were veterinary nurses or technicians, and 3 (~2%) were interns. Although there was a majority agreement (>50% in a single category) in 15 of the 16 cases, ASA-PSC were spread over at least three ASA-PS classifications for every case. Overall agreement was considered only fair (κ = 0.24, mean ± SD agreement 46 ± 7%). When comparing grouped data (ASA-PSC I-II versus III-V) overall agreement remained fair (κ = 0.36, mean ± SD agreement 69 ± 19%). There was no difference in ASA-PSC assignment between any of the demographic groups investigated. This study suggests major discrepancies can occur between observers given identical information when using the ASA-PSC to categorise health status in compromised small animal patients. The significant potential for interobserver variability in classification allocation should be borne in mind when the ASA-PSC is used for clinical, scientific and statistical purposes. © 2013 The Authors. Veterinary Anaesthesia and Analgesia © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

Autonomous excursions using tablets and smartphones

NASA Astrophysics Data System (ADS)

Marra, Wouter; Groothengel, Marin; van de Grint, Liesbeth; Karssenberg, Derek; Stouthamer, Esther

2017-04-01

Excursions and fieldworks are valuable components for geosciences education. However, field activities can be time consuming for teachers and pose a logistical challenge to fit in regular courses. Furthermore, the participation of students diminishes with group size in case of instructor-led outings. We are developing excursions that students can follow autonomously without a teacher present, using instructions, assignments and background information on tablets and smartphones. The goal of this approach is to increase the level of active participation, and to reduce logistical and time table issues. We developed a bike-excursion about the landscape and geology in the vicinity of our University. Such excursion was on the wish-list for several years, but posed a logistical challenge for the group of about 80 students in the available timeslot. In our approach, students had a time-window of two weeks in which they could finish the excursion in groups of 2. 8-Inch tablets with water- and shock-proof cases were available for this excursion. For the excursion we used three apps: 1) IZI-Travel for providing the route, spoken navigation instructions, spoken explanations at stops, location-related images, assignments as text, and multiple-choose questions. 2) PDF-Maps for providing geo-referenced maps. 3) ESRI Collector which the students used to digitize polygons on a map, and to collect geo-referenced photos with explanation. These data were answers to assignments and were later used in a tutorial on campus. The assignments where students had to collect data, and the small group size (pairs) increased the level of active participation. The use of a final tutorial on campus was important for the autonomous excursion, as it gave students the opportunity to discuss their observations and questions with their teacher. The developed teaching materials are available online to use and adapt for others. Parts could be useful for other universities and schools in the vicinity of the excursion location.

Volcanic Stratigraphy of the Quaternary Rhyolite Plateau in Yellowstone National Park

USGS Publications Warehouse

Christiansen, Robert L.; Blank, H. Richard

1972-01-01

The volcanic sequence of the Quaternary Yellowstone plateau consists of rhyolites and basalts representing three volcanic cycles. The major events of each cycle were eruption of a voluminous ash-flow sheet and formation of a large collapse caldera. Lesser events of each cycle were eruption of precaldera and postcaldera rhyolitic lava flows and marginal basaltic lavas. The three major ash-flow sheets are named and designated in this report as formations within the Yellowstone Group. The lavas are assigned to newly named formations organized around the three ash-flow sheets of the Yellowstone Group to represent the volcanic cycles. Rocks of the first volcanic cycle comprise the precaldera Junction Butte Basalt and rhyolite of Broad Creek; the Huckleberry Ridge Tuff of the Yellowstone Group; and the postcaldera Lewis Canyon Rhyolite and basalt of The Narrows. Rocks of the second volcanic cycle do not crop out within Yellowstone National Park, and only the major unit, the Mesa Falls Tuff of the Yellowstone Group, is named here. The third volcanic cycle is represented by the precaldera Mount Jackson Rhyolite and Undine Falls Basalt; the Lava Creek Tuff of the Yellowstone Group; and the postcaldera Plateau Rhyolite and five post-Lava Creek basaltic sequences. Collapse to form the compound and resurgent Yellowstone caldera was related to eruption of the Lava Creek Tuff. The Plateau Rhyolite is divided into six members - the Mallard Lake, Upper Basin, Obsidian Creek, Central Plateau, Shoshone Lake Tuff, and Roaring Mountain Members; all but the Mallard Lake postdate resurgent doming of the caldera. The basalts are divided into the Swan Lake Flat Basalt, Falls River Basalt, basalt of Mariposa Lake, Madison River Basalt, and Osprey Basalt. Sediments are intercalated in the volcanic section below the Huckleberry Ridge and Mesa Falls Tuffs and within the Junction Butte Basalt, sediments and basalts of The Narrows, Undine Falls Basalt, Plateau Rhyolite, and Osprey Basalt.

Optical Properties and Crystallization of Natural Waxes at Several Annealing Temperatures: a Terahertz Time-Domain Spectroscopy Study

NASA Astrophysics Data System (ADS)

Tian, Lu; Xu, Xinlong

2018-03-01

The thermal analysis and optical properties of paraffin wax, beeswax, and liquid paraffin annealed at variable temperatures have been conducted using terahertz time-domain spectroscopy (THz-TDS) coupled with SEM methods. The characteristic optical properties of natural waxes can be used to analyze natural wax adulteration. The lamellar structure of paraffin wax and beeswax grew by a sheet of chain expansion. Furthermore, the crystallization process of paraffin wax can be assigned: rotator-solid transition and liquid-solid ones. According to the temperature-dependent refractive index curves, the refractive index of paraffin wax varies from large to small followed by rotator-liquid transition, untreated one, and liquid-solid one, respectively. The results indicated that THz-TDS has been proved to be of great potential in identification the crystallization of waxes.

Structure-Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes

PubMed Central

Pelay-Gimeno, Marta; Glas, Adrian; Koch, Oliver; Grossmann, Tom N

2015-01-01

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus making the development of PPI inhibitors extremely valuable. The identification of selective inhibitors is challenging because of the shallow and extended nature of PPI interfaces. Inhibitors can be obtained by mimicking peptide binding epitopes in their bioactive conformation. For this purpose, several strategies have been evolved to enable a projection of side chain functionalities in analogy to peptide secondary structures, thereby yielding molecules that are generally referred to as peptidomimetics. Herein, we introduce a new classification of peptidomimetics (classes A–D) that enables a clear assignment of available approaches. Based on this classification, the Review summarizes strategies that have been applied for the structure-based design of PPI inhibitors through stabilizing or mimicking turns, β-sheets, and helices. PMID:26119925

How to perform a critical appraisal of diagnostic tests: 7 steps.

PubMed

Chughtai, Aamer; Kelly, Aine Marie; Cronin, Paul

2015-06-01

The critically appraised topic (CAT) is a format in evidence-based practice for sharing information. A CAT is a standardized way of summarizing the most current research evidence focused on a pertinent clinical question. Its aim is to provide both a critique of the most up-to-date retrieved research and an indication of the clinical relevance of results. A clinical question is initially generated following a patient encounter, which leads to and directs a literature search to answer the clinical question. Studies obtained from the literature search are assigned a level of evidence. This allows the most valid and relevant articles to be selected and to be critically appraised. The results are summarized, and this information is translated into clinically useful procedures and processes.

Strategies for Global Optimization of Temporal Preferences

NASA Technical Reports Server (NTRS)

Morris, Paul; Morris, Robert; Khatib, Lina; Ramakrishnan, Sailesh

2004-01-01

A temporal reasoning problem can often be naturally characterized as a collection of constraints with associated local preferences for times that make up the admissible values for those constraints. Globally preferred solutions to such problems emerge as a result of well-defined operations that compose and order temporal assignments. The overall objective of this work is a characterization of different notions of global preference, and to identify tractable sub-classes of temporal reasoning problems incorporating these notions. This paper extends previous results by refining the class of useful notions of global temporal preference that are associated with problems that admit of tractable solution techniques. This paper also answers the hitherto open question of whether problems that seek solutions that are globally preferred from a Utilitarian criterion for global preference can be found tractably.

37 CFR 1.76 - Application data sheet.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Application data sheet. 1.76... Application data sheet. (a) Application data sheet. An application data sheet is a sheet or sheets, that may... bibliographic data, arranged in a format specified by the Office. An application data sheet must be titled...

MIS 5e sea level: up to what point can we use literature reviews to answer the most pressing questions on the Last Interglacial ice sheets?

NASA Astrophysics Data System (ADS)

Rovere, A.; Raymo, M. E.

2014-12-01

During MIS 5e (between ~128 and 116 kyr BP) greenhouse gas concentrations were comparable to pre-industrial levels, summer insolation was higher by ~10% at high latitudes and polar temperatures in both hemispheres were about 3-5 °C warmer than today. Sea level (SL) at this time has been a subject of numerous studies (and some debate) with ~1000 sites with MIS 5e sea level markers recognized worldwide. Recently, Kopp et al. (Nature, 2009) and Dutton & Lambeck (Science, 2012) analyzed worldwide datasets of sea level markers pertaining to the last interglacial. After accounting for GIA, they reached similar conclusions that eustatic (i.e., globally averaged) sea level (ESL) was between +5 and +9.4 m above modern during MIS 5e. Furthermore, Kopp et al. (Nature, 2009; GJI, 2013) suggest that sea level was not uniform during the LIG, but instead underwent at least two rapid oscillations including a rapid late 5e rise first proposed by Hearty et al. (QSR, 2007) and later by O'Leary et al. (Nat. Geo., 2013). Investigating the temporal and geographic variability of MIS 5e sea level opens new lines of research, in particular the possibility to fingerprint (Hay et al., QSR, 2014) the source of the proposed rapid ice sheet collapse near the end of the Last Interglacial. In this presentation we ask: can we use a database of published sea level estimates for this purpose? To answer this question, we built a relative sea level (RSL) database using RSLcalc 2.0; this is a relational database specifically designed to review relative sea level data points while keeping all the relevant information contained in the original publications. RSlcalc allows to estimate the measurement error (on the actual elevation of the SL feature), the error on the indicative range (the elevation range occupied by a sea level indicator) as well as the reference water level (the relationship between the marker and the former sea level). We show that the majority of published data have an accuracy of few meters at best and, in most cases, are not precise enough for sea level fingerprinting. We conclude that the use of topographic-grade survey techniques is paramount in the study of paleo-sea levels and that revisiting known sites using such techniques is a priority for the understanding of polar ice volume and sea level changes during past interglacials

[A survey of utilization of and problems with the MSDS in chemical substances management at workplaces in Kanagawa Prefecture].

PubMed

Koshi, Kimiko; Mouri, Tetuo; Sugimori, Hiroki; Numano, Takashi; Ashida, Toshifumi; Hiro, Hisanori; Miyake, Hitoshi; Fukushima, Michiko; Ishiwata, Kouichi

2002-09-01

Kanagawa Occupational Health Promotion Center conducted a survey on how the MSDS is utilized at workplaces with more than 50 employees handling chemical substances, and what measures are taken to help employees to thoroughly understand information in the Material Safety Data Sheet (MSDS). Questionnaires were sent out to 265 enterprises in Kanagawa prefecture, putting questions to industrial physicians and industrial hygiene supervisors. The objective of the survey was to find out how MSDS is adopted in the system to manage occupational health, what improvements the survey respondents want in MSDS and what expectations the respondents have of our center. 193 enterprises (72.8%) returned answers to the questionnaire. The major findings are as follows. (1) In many companies, information on hazardous/toxic materials is "controlled by a division using such materials", and roughly half of the companies have compiled a common list shared throughout the company. (2) For the most part suppliers submit to the MSDS. Larger companies have a higher rate of posting up or filing the MSDS at their workplaces. Only 25.8% of the companies "rewrite the MSDS so that workers can understand it." (3) Companies that carry out a hazard/toxicity assessment before introducing a new chemical substance account for 72.1%, which is higher than we expected. It indicates that even though the companies don't manage the MSDS adequately, they are highly concerned about hazard control of chemical substances. (4) The rate of answering that "the current MSDS is not easy to understand" is higher among large-sized enterprises and lower among enterprises with fewer than 300 employees. (5) Asked what improvement needs to be made on the MSDS, the industrial physicians and industrial hygiene supervisors gave same answers such as "Workers find the terminology difficult to understand." and "Levels of toxicity can't be clearly identified." (6) The respondents expect our center to provide information for the MSDS. In conclusion, it is considered that in order to prepare understandable MSDSs to workers in enterprises, the role of our center to provide information and education on the MSDS to respondents was important.

NMR Studies of Dynamic Biomolecular Conformational Ensembles

PubMed Central

Torchia, Dennis A.

2015-01-01

Multidimensional heteronuclear NMR approaches can provide nearly complete sequential signal assignments of isotopically enriched biomolecules. The availability of assignments together with measurements of spin relaxation rates, residual spin interactions, J-couplings and chemical shifts provides information at atomic resolution about internal dynamics on timescales ranging from ps to ms, both in solution and in the solid state. However, due to the complexity of biomolecules, it is not possible to extract a unique atomic-resolution description of biomolecular motions even from extensive NMR data when many conformations are sampled on multiple timescales. For this reason, powerful computational approaches are increasingly applied to large NMR data sets to elucidate conformational ensembles sampled by biomolecules. In the past decade, considerable attention has been directed at an important class of biomolecules that function by binding to a wide variety of target molecules. Questions of current interest are: “Does the free biomolecule sample a conformational ensemble that encompasses the conformations found when it binds to various targets; and if so, on what time scale is the ensemble sampled?” This article reviews recent efforts to answer these questions, with a focus on comparing ensembles obtained for the same biomolecules by different investigators. A detailed comparison of results obtained is provided for three biomolecules: ubiquitin, calmodulin and the HIV-1 trans-activation response RNA. PMID:25669739

Lost in translation or deliberate falsification? Genetic analyses reveal erroneous museum data for historic penguin specimens.

PubMed

Boessenkool, Sanne; Star, Bastiaan; Scofield, R Paul; Seddon, Philip J; Waters, Jonathan M

2010-04-07

Historic museum specimens are increasingly used to answer a wide variety of questions in scientific research. Nevertheless, the scientific value of these specimens depends on the authenticity of the data associated with them. Here we use individual-based genetic analyses to demonstrate erroneous locality information for archive specimens from the late nineteenth century. Specifically, using 10 microsatellite markers, we analysed 350 contemporary and 43 historic yellow-eyed penguin (Megadyptes antipodes) specimens from New Zealand's South Island and sub-Antarctic regions. Factorial correspondence analysis and an assignment test strongly suggest that eight of the historic specimens purportedly of sub-Antarctic origin were in fact collected from the South Island. Interestingly, all eight specimens were obtained by the same collector, and all are currently held in the same museum collection. Further inspection of the specimen labels and evaluation of sub-Antarctic voyages did not reveal whether the erroneous data are caused by incorrect labelling or whether deliberate falsification was at play. This study highlights a promising extension to the well-known applications of assignment tests in molecular ecology, which can complement methods that are currently being applied for error detection in specimen data. Our results also serve as a warning to all who use archive specimens to invest time in the verification of collection information.

Micro-fluidic partitioning between polymeric sheets for chemical amplification and processing

DOEpatents

Anderson, Brian L.

2017-01-24

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.

Micro-fluidic partitioning between polymeric sheets for chemical amplification and processing

DOEpatents

Anderson, Brian L.

2015-05-26

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.

Local stakeholders' perception of landslide and flood risks in Iasi County, Romania

NASA Astrophysics Data System (ADS)

Ciprian Margarint, Mihai; Niculita, Mihai; Rosu, Lucian

2015-04-01

Risk perception is an important issue for an efficient management and mitigation measures of natural hazards and theirs negative consequences on social and economic activity. At administrative unit scale (LAU2), local stakeholders play an effective role in case of an emergency situation, regarding the warning and alerting the population, collaboration with specialized institution and managing material assistance during and after the crisis. In addition they are among the best connoisseurs of local community and places, and consequently they could substantial help the national level forces during emergency situations. These issues argues the high degree of responsibilities assigned to Romanian mayors, and is reflected in the legislation in terms of evaluation of damages produced and the management of natural hazards, like landslide and floods. Also their degree of awareness can assess more accurately the collective perception against the individual one. In this work we have assessed the local stakeholders' perception for natural risks in general, and particularly for landslides and floods. We have tested the discrepancies of the specific risks perception and an assessment of correspondence between scientific outputs versus the subjective judgement the administrative decision makers. This approach was based on a questionnaire which was applied in the summer of 2014, to all 98 mayors from Iasi County, north-east Romania. It contained 12 questions structured in a specific mode, from general to particular. The assessment of the answers provided from the commune halls, was realized with integration in a GIS environment of codes assigned to each question, and the overlay with the scientific outputs regarding landslide occurrence and susceptibility and floods risk maps. The differences between the outputs of the questionnaires and the scientific outputs of landslide and flood risk was further analyzed and interpreted. There were registered large variations of answers and important discrepancies between scientific results and the stakeholders' estimations, both for landslides and flood components. Farther multicriterial analysis (clustering method) was applied for highlighting a correspondance between the distance to certain risk areas and stakeholders perception. As a main conclusion we can state that the decision makers perception is strongly influenced by their personal and recent experiences but also by the distance to the source of risk.

OPTIGOV - A new methodology for evaluating Clinical Governance implementation by health providers

PubMed Central

2010-01-01

Background The aim of Clinical Governance (CG) is to the pursuit of quality in health care through the integration of all the activities impacting on the patient into a single strategy. OPTIGOV (Optimizing Health Care Governance) is a methodology for the assessment of the level of implementation of CG within healthcare organizations. The aim of this paper is to explain the process underlying the development of OPTIGOV, and describe its characteristics and steps. Methods OPTIGOV was developed in 2006 by the Institute of Hygiene of the Catholic University of the Sacred Heart and Eurogroup Consulting Alliance. The main steps of the process were: choice of areas for analysis and questionnaire development, based on a review of scientific literature; assignment of scores and weights to individual questions and areas; implementation of a software interfaceable with Microsoft Office. Results OPTIGOV consists of: a) a hospital audit with a structured approach; b) development of an improvement operational plan. A questionnaire divided into 13 areas of analysis is used. For each area there is a form with a variable number of questions and "closed" answers. A score is assigned to each answer, area of analysis, healthcare department and unit. The single scores can be gathered for the organization as a whole. The software application allows for collation of data, calculation of scores and development of benchmarks to allow comparisons between healthcare organizations. Implementation consists of three stages: the preparation phase includes a kick off meeting, selection of interviewees and development of a survey plan. The registration phase includes hospital audits, reviewing of hospital documentation, data collection and score processing. Lastly, results are processed, inserted into a final report, and discussed in a meeting with the Hospital Board and in a final workshop. Conclusions The OPTIGOV methodology for the evaluation of CG implementation was developed with an evidence-based approach. The ongoing adoption of OPTIGOV in several projects will put to the test its potential to realistically represent the organization status, pinpoint criticalities and transferable best practices, provide a plan for improvement, and contribute to triggering changes and pursuit of quality in health care. PMID:20565967

[Equality in clinical practice. Proposals for patients, professionals and managers and policies to limit discrimination].

PubMed

Soler-González, J; Fernández de Sanmamed, M J; Gérvas, J

2015-01-01

To make feasible and practical proposals to improve equality in the course of clinical care during the patient-provider encounter. Design: A focus group study was conducted with a qualitative approach from the perspective of reducing health inequalities in the clinic. Setting: A classroom discussion focused on equality in clinical work. Subjects: 98 professionals from several countries. Measurement tools: An analysis of the responses was performed, grouped by themes interpreted by analysts, and restructured to provide consistency and uniformity to responses given. Data were collected using a questionnaire with open answers, allowing free-form answers to three general questions that addressed improving equality from the perspective of the professional themselves, patients, and health policy managers. No saturation horizon of analytical discourses was set, to understand that from this subjective prioritization of opinion there is no possibility that discourses reached saturation. Responses were added to the 3 principal axes, recommending that professionals be aware of their discriminatory ability. Patients were asked to trust their health professionals and that they should be assigned to a professional. It was also proposed that managers provide information systems, help reduce health inequalities, and encourage professional freedom. The paper presents concrete measures to promote improved equality in clinics during the delivery of health care. Copyright © 2014 SECA. Published by Elsevier Espana. All rights reserved.