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Sample records for anton paier kerli

  1. Anton's Syndrome and Eugenics

    PubMed Central

    Frahm-Falkenberg, Siska

    2011-01-01

    Anton's syndrome is arguably the most striking form of anosognosia. Patients with this syndrome behave as if they can see despite their obvious blindness. Although best known for his description of asomatognosia and visual anosognosia, Gabriel Anton (1858-1933) made other significant contributions to the clinical neurosciences, including pioneering work in neurosurgery, neuropsychology, and child psychiatry. However, it has not been recognized in the English literature that Anton was also a dedicated advocate of eugenics and racial hygiene. This paper provides a case of Anton's syndrome and puts the works of Gabriel Anton into their historic context. PMID:21779298

  2. Anton Grdina Primary Achievement Program

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Anton project presents a partnership between NASA Lewis, CMHA, and the Cleveland Public Schools. The intent of this project is to empower parents to work with their children in science and math activities.

  3. Anton Makarenko: Contribution to Soviet Educational Theory.

    ERIC Educational Resources Information Center

    Zilberman, Victor

    1988-01-01

    Examines the relationship of Anton Makarenko's educational theories to Russian history, tradition, and culture. Analyzes the influence of Russian and foreign prerevolutionary thinking on Makarenko's major theories. Discusses his major educational concepts (i.e., discipline, education through work, collectives, and the teacher's role) and views of…

  4. Anton Chekhov: Yalta Years, 1899-1904.

    ERIC Educational Resources Information Center

    Brinkle, Lydle

    Anton Pavlovich Chekhov spent 6 of the last 7 years of his life at Yalta (located on the Crimean Peninsula) where he had a house constructed in order that he might live in a climate favorable to his failing health. During these years Chekhov married the actress Olga Knipper and met Leo Tolstoy, who was near the end of his life. Chekhov also…

  5. Anton's Syndrome due to Bilateral Ischemic Occipital Lobe Strokes.

    PubMed

    Zukić, Sanela; Sinanović, Osman; Zonić, Lejla; Hodžić, Renata; Mujagić, Svjetlana; Smajlović, Edina

    2014-01-01

    We present a case of a patient with Anton's syndrome (i.e., visual anosognosia with confabulations), who developed bilateral occipital lobe infarct. Bilateral occipital brain damage results in blindness, and patients start to confabulate to fill in the missing sensory input. In addition, the patient occasionally becomes agitated and talks to himself, which indicates that, besides Anton's syndrome, he might have had Charles Bonnet syndrome, characterized by both visual loss and hallucinations. Anton syndrome, is not so frequent condition and is most commonly caused by ischemic stroke. In this particular case, the patient had successive bilateral occipital ischemia as a result of massive stenoses of head and neck arteries.

  6. Recurrent bilateral occipital infarct with cortical blindness and anton syndrome.

    PubMed

    Kwong Yew, Kiu; Abdul Halim, Sanihah; Liza-Sharmini, Ahmad Tajudin; Tharakan, John

    2014-01-01

    Bilateral cortical blindness and Anton syndrome, are most commonly caused by ischaemic stroke. In this condition, patients have loss of vision but deny their blindness despite objective evidence of visual loss. We report a case of a patient with multiple cardiovascular risk factors who developed recurrent bilateral occipital lobe infarct with Anton syndrome. A suspicion of this condition should be raised when the patient has denial of blindness in the presence of clinical and radiological evidence of occipital lobe injury. Management of this condition should focus on the underlying cause, in which our patient requires secondary stroke prevention and rehabilitation. PMID:24744933

  7. The Distribution of Accommodation Rates in St. Anton, Austria.

    ERIC Educational Resources Information Center

    Eysberg, Cees D.

    1984-01-01

    For use in college geography courses which teach spatial analysis, this case study investigated whether hotel rates in the ski resort of St. Anton, Austria, are affected by the hotel's proximity to ski lifts and apres ski establishments. Results showed that tourists are sensitive to distance; spatial behavior is predictable. (RM)

  8. IN MEMORIAM: Hermann Anton Haus, 1925 2003

    NASA Astrophysics Data System (ADS)

    2004-08-01

    Photograph Hermann Anton Haus, an Institute Professor at the Massachusetts Institute of Technology (MIT), was to have been a Keynote Speaker at the Fluctuations and Noise in Photonics and Quantum Optics Conference, from which the papers in this special issue derive. Sadly, on May 21, 2003 - less than two weeks before the conference - Professor Haus succumbed to a heart attack after arriving home in Lexington, Massachusetts, from his regular, 15-mile commute by bicycle from MIT. He was 77. Throughout his lengthy and illustrious career, Professor Haus had repeatedly and very successfully addressed problems of fluctuations and noise, with special focus on the fundamental issues that arise in quantum optics. To honour Professor Haus' legacy to our technical community, this special issue of Journal of Optics B: Quantum and Semiclassical Optics is dedicated to his memory. Professor Haus was born in Ljubljana, Slovenia, in the former Yugoslavia, on 8 August 1925. After attending the Technische Hochschule, Graz, and the Technische Hochschule, Wien, in Austria, he received his Bachelor of Science degree from Union College in Schenectady, New York in 1949. In 1951, he graduated from Rensselaer Polytechnic Institute with a Master of Science in Electrical Engineering, and came to MIT, where he earned his Doctorate of Science and joined the faculty in 1954. He was promoted to Associate Professor in 1958, to Professor in 1962, and to Elihu Thomson Professor in 1973. In 1986, he was conferred the honour of Institute Professor. Professor Haus had a lifelong fascination with noise. While still an undergraduate at Union College, he became aware of Norbert Wiener's theories of statistical phenomena - the new mathematics needed to understand and quantify the random fluctuations we refer to as noise. So it was that noise theory formed the core of Professor Haus' research during the 1950s: noise in electron beams, noise in microwave amplifiers, and noise in amplifier cascades. Two of

  9. IN MEMORIAM: Hermann Anton Haus, 1925 2003

    NASA Astrophysics Data System (ADS)

    2004-08-01

    Photograph Hermann Anton Haus, an Institute Professor at the Massachusetts Institute of Technology (MIT), was to have been a Keynote Speaker at the Fluctuations and Noise in Photonics and Quantum Optics Conference, from which the papers in this special issue derive. Sadly, on May 21, 2003 - less than two weeks before the conference - Professor Haus succumbed to a heart attack after arriving home in Lexington, Massachusetts, from his regular, 15-mile commute by bicycle from MIT. He was 77. Throughout his lengthy and illustrious career, Professor Haus had repeatedly and very successfully addressed problems of fluctuations and noise, with special focus on the fundamental issues that arise in quantum optics. To honour Professor Haus' legacy to our technical community, this special issue of Journal of Optics B: Quantum and Semiclassical Optics is dedicated to his memory. Professor Haus was born in Ljubljana, Slovenia, in the former Yugoslavia, on 8 August 1925. After attending the Technische Hochschule, Graz, and the Technische Hochschule, Wien, in Austria, he received his Bachelor of Science degree from Union College in Schenectady, New York in 1949. In 1951, he graduated from Rensselaer Polytechnic Institute with a Master of Science in Electrical Engineering, and came to MIT, where he earned his Doctorate of Science and joined the faculty in 1954. He was promoted to Associate Professor in 1958, to Professor in 1962, and to Elihu Thomson Professor in 1973. In 1986, he was conferred the honour of Institute Professor. Professor Haus had a lifelong fascination with noise. While still an undergraduate at Union College, he became aware of Norbert Wiener's theories of statistical phenomena - the new mathematics needed to understand and quantify the random fluctuations we refer to as noise. So it was that noise theory formed the core of Professor Haus' research during the 1950s: noise in electron beams, noise in microwave amplifiers, and noise in amplifier cascades. Two of

  10. [Sensitive character: an almost forgotten personality disorder - illustrated by the case Anton Reiser].

    PubMed

    Tölle, R

    2013-03-01

    n his famous 1918 book „The sensitive relative delusion” Ernst Kretschmer not only described this specific delusional disorder but also the underlying sensitive personality disorder. Until now, relatively little attention has been paid to this part of his work. The incomplete reception is outlined, followed by a description of the symptoms, psychodynamics and course of sensitive personality disorder. The interpretation of "Anton Reiser: a psychological novel" - the autobiographical work by Karl Philipp Moritz in 1785 – is used as an example since it describes Anton Reiser as a sensitive personality. PMID:22286387

  11. An appreciation of Christiane Groehen: the correspondence between Charles Darwin and Anton Dohrn.

    PubMed

    Browne, Janet

    2015-01-01

    Anton Dohrn was introduced to Darwinism by Ernst Haeckel during his student years at Jena, and became an eager disciple of Charles Darwin's work. He founded the Stazione Zoologica in 1872. Darwin became a patron of Dohrn's Stazione, and the two naturalists corresponded regularly. This article discusses their relationship and the contributions of Christiane Groeben to its elucidation. PMID:26013199

  12. Paint and Pedagogy: Anton Ehrenzweig and the Aesthetics of Art Education

    ERIC Educational Resources Information Center

    Williamson, Beth

    2009-01-01

    Anton Ehrenzweig's work training art teachers at Goldsmiths College in London was groundbreaking in its field. The work of the studio fed back into Ehrenzweig's writings through his reflections on teaching and the work produced in end of year shows. In "The Hidden Order of Art" (1967), he theorised the creative process in psychoanalytic terms and…

  13. Anton Makarenko: The "John Dewey of the U.S.S.R."

    ERIC Educational Resources Information Center

    Gehring, Thom; Bowers, Fredalene B.; Wright, Randall

    2005-01-01

    There are a few correctional educators whose work is historically so influential that it is difficult to summarize in an article. Anton Makarenko was among this very select group; this is merely an attempt to outline his work. One way to introduce Makarenko to correctional educators is to focus on some of the seemingly incongruous elements of his…

  14. Anton-Babinski syndrome in an old patient: a case report and literature review.

    PubMed

    Chen, Jiann-Jy; Chang, Hsin-Feng; Hsu, Yung-Chu; Chen, Dem-Lion

    2015-03-01

    Anton-Babinski syndrome is a rare disease featuring bilateral cortical blindness and anosognosia with visual confabulation, but without dementia or any memory impairment. It has a unique neuropsychiatric presentation and should be highly suspected in those with odd visual loss and imaging evidence of occipital lobe injury. In the case discussed herein, a 90-year-old man presented with bilateral blindness, obvious anosognosia, and vivid visual confabulation, which he had had for 3 days. Brain computed tomography demonstrated recent hypodense infarctions at the bilateral occipital lobes. Thus, the patient was diagnosed with Anton-Babinski syndrome. Because of his age and the thrombolytic therapy during the golden 3 hours after ischemic stroke, the patient received aspirin therapy rather than tissue plasminogen activator or warfarin. He gradually realized he was blind during the following week, but died of pneumonia 1 month later. In the literature, it is difficult to establish awareness of blindness in patients with Anton-Babinski syndrome, but optimistically, in one report, a patient was aware of blindness within 2 weeks, without vision improvement. Our case illustrates that elderly patients with Anton-Babinski syndrome can partially recover and that 1 week is the shortest time for the establishment of awareness of blindness for sufferers without vision improvement.

  15. Questions Biology Teachers Are Asking: An Interview with Anton E. Lawson

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2005-01-01

    A well-known educator and researcher Anton E. Lawson highlights critical points on effective teaching, meaningful learning, and problem solving. He feels that every citizen should know that science is a collective enterprise that seeks to explain nature based on the open generation and test of ideas.

  16. Anton-Babinski syndrome in an old patient: a case report and literature review.

    PubMed

    Chen, Jiann-Jy; Chang, Hsin-Feng; Hsu, Yung-Chu; Chen, Dem-Lion

    2015-03-01

    Anton-Babinski syndrome is a rare disease featuring bilateral cortical blindness and anosognosia with visual confabulation, but without dementia or any memory impairment. It has a unique neuropsychiatric presentation and should be highly suspected in those with odd visual loss and imaging evidence of occipital lobe injury. In the case discussed herein, a 90-year-old man presented with bilateral blindness, obvious anosognosia, and vivid visual confabulation, which he had had for 3 days. Brain computed tomography demonstrated recent hypodense infarctions at the bilateral occipital lobes. Thus, the patient was diagnosed with Anton-Babinski syndrome. Because of his age and the thrombolytic therapy during the golden 3 hours after ischemic stroke, the patient received aspirin therapy rather than tissue plasminogen activator or warfarin. He gradually realized he was blind during the following week, but died of pneumonia 1 month later. In the literature, it is difficult to establish awareness of blindness in patients with Anton-Babinski syndrome, but optimistically, in one report, a patient was aware of blindness within 2 weeks, without vision improvement. Our case illustrates that elderly patients with Anton-Babinski syndrome can partially recover and that 1 week is the shortest time for the establishment of awareness of blindness for sufferers without vision improvement. PMID:25515048

  17. An appreciation of Christiane Groehen: the correspondence between Charles Darwin and Anton Dohrn.

    PubMed

    Browne, Janet

    2015-01-01

    Anton Dohrn was introduced to Darwinism by Ernst Haeckel during his student years at Jena, and became an eager disciple of Charles Darwin's work. He founded the Stazione Zoologica in 1872. Darwin became a patron of Dohrn's Stazione, and the two naturalists corresponded regularly. This article discusses their relationship and the contributions of Christiane Groeben to its elucidation.

  18. Crystal structure and magnetic properties of potassium erbium double tungstate KEr(WO4)2

    NASA Astrophysics Data System (ADS)

    Borowiec, M. T.; Dyakonov, V. P.; Wozniak, K.; Dobrzycki, L.; Berkowski, M.; Zubov, E. E.; Michalski, E.; Szewczyk, A.; Gutowska, M. U.; Zayarnyuk, T.; Szymczak, H.

    2007-02-01

    Results of structural, magnetic and specific heat investigations of the potassium erbium double tungstate, KEr(WO4)2, are presented. Potassium erbium double-tungstate KEr(WO4)2 single crystals have been grown by the top-seeded solution growth method (TSSG) and modified Czochralski techniques. It crystallizes in the monoclinic crystal structure (C 2/c space group). The unit cell contains four formula units and is described by parameters a = 10.615(2) Å, b = 10.316(2) Å, c = 7.534(2) Å, β = 130.73(3)°. From the x-ray diffraction measurements the fractional atomic coordinates, displacement parameters and interatomic distances have been determined. The specific heat C(T) of the KEr(WO4)2 crystal has been measured over a temperature range of 0.6-300 K. The susceptibility has been studied at T = 0.25-4.0 K. The magnetic phase transition was observed at a temperature of 0.48 K. The magnetization has been measured in the temperature region from 4.2 to 60 K and in magnetic field up to 1.6 T. A strong anisotropy of magnetic properties was found. The temperature and field dependences of susceptibility and magnetization data were used for both elucidation of character of the magnetic ordering and calculation of the exchange and dipole-dipole interaction energies as well as for determination of the possible magnetic structure of KEr(WO4)2.

  19. Seismology at the Australian National University; an interview with Anton L. Hales

    USGS Publications Warehouse

    Spall, H.

    1980-01-01

    Dr. Anton L. Hales is a leading seismologist who has just retired as Director of the Research School of Earth Sciences at the Australian National University (ANU), Canberra. Prior to that, he headed the Geosciences Division at the University of Texas at Dallas, and, before that, he was Director of the Bernard Price Institute of Geophysical Research at the University of the Witwatersrand Johannesburg, South Africa. he is about to step down as President of the International Geodynamics Commission. Dr. Hales' research has involved marine geophysics, the travel times of seismic waves, and the structure of the Earth's crust and upper mantle. 

  20. [Johannes Anton von Mikulicz-Radecki (1850-1905). His contributions to the development of urology].

    PubMed

    Zajaczkowski, T; Zamann, A M

    2010-02-01

    On June 14, 1905, Johann Anton von Mikulicz-Radecki, one of the most famous surgeons of the time, died. He was a disciple of famous Theodor Billroth of Vienna and the teacher of Ferdinand Sauerbruch in Breslau. Mikulicz-Radecki's merits in the field of the history of medicine are based on his achievements in developing the system of antisepsis and asepsis. He also devoted himself to urological surgery, and his name is linked with diseases, operations, and construction of new medical instruments. Mikulicz-Radecki created two surgical schools, one in Cracow and a second one in Breslau, where he worked for over 15 years until his death.

  1. Anton Dohrn and the problems of 19th century phylogenetic morphology.

    PubMed

    Breidbach, Olaf; Ghiselin, Michael T

    2007-05-01

    According to Anton Dohrn, evolutionary development was performed in a single progressive lineage where some proto-annelid initiated an evolutionary development that went straight on via annelids and lower vertebrates to man. From that line, a kind of metamorphosing nature, certain branches were derived, like protists or worms or even tunicates, which Dohrn thought off as degenerating groups. With that concept Dohrn came close to typological ideas of his time. Nevertheless, recent evo-devo literature seems to be influenced by Dohrn's outline of evolution.

  2. Thermal Properties of Capparis Decidua (ker) Fiber Reinforced Phenol Formaldehyde Composites

    SciTech Connect

    Singh, G. P.; Mangal, Ravindra; Bhojak, N.; Dixit, Manasvi; Saxena, N. S.

    2010-06-29

    Simultaneous measurement of effective thermal conductivity ({lambda}), effective thermal diffusivity ({kappa}) and specific heat of Ker fiber reinforced phenol formaldehyde composites have been studied by transient plane source (TPS) technique. The samples of different weight percentage typically (5, 10, 15, 20 and 25%) have been taken. It is found that values of effective thermal conductivity and effective thermal diffusivity of the composites decrease, as compared to pure phenol formaldehyde, as the fraction of fiber loading increases. Experimental data is fitted on Y. Agari model. Values of thermal conductivity of composites are calculated with two models (Rayleigh, Maxwell and Meredith-Tobias model). Good agreement between theoretical and experimental result has been found.

  3. Antone Tarazi: the first Palestinian neurosurgeon and the first neurosurgeon in Jordan: a neurosurgeon of two countries.

    PubMed

    Awad, Ahmed J; Jane, John A

    2014-12-01

    Antone (Tony) Tarazi (1927-1999) was the first Palestinian neurosurgeon and the first neurosurgeon in Jordan. In 1952, Tarazi received his medical degree from the American University of Beirut in Lebanon. After completing neurosurgery training at the Montreal Neurological Institute in 1960, he returned to Palestine to practice neurosurgery in both Palestine and Jordan. For almost 10 years, he alone carried the load of neurosurgery for a population of >3 million people. His skills and knowledge enabled him to achieve admirable results with limited available resources. Tarazi was the president of the Palestinian Neurosurgical Society, a member of Jordan medical societies, and a member of the American Association of Neurological Surgeons. His continuous efforts to improve medical services extended beyond neurosurgery to many other fields. This article recounts Antone Tarazi's achievements and contributions to neurosurgery in Palestine and Jordan.

  4. Fast TracKer: A fast hardware track trigger for the ATLAS detector

    NASA Astrophysics Data System (ADS)

    Pandini, Carlo

    2016-07-01

    The trigger system at the ATLAS experiment is designed to lower the event rate occurring from the nominal bunch crossing rate of 40 MHz to about 1 kHz for a LHC luminosity of the order of 1034cm-2s-1. To achieve high background rejection while maintaining good efficiency for interesting physics signals, sophisticated algorithms are needed which require an extensive use of tracking information. The Fast TracKer (FTK) trigger system, part of the ATLAS trigger upgrade program, is a highly parallel hardware device designed to perform track-finding at 100 kHz. Modern, powerful Field Programmable Gate Arrays (FPGAs) form an important part of the system architecture, and the combinatorial problem of pattern recognition is solved by 8000 standard-cell ASICs used to implement an Associative Memory architecture. The availability of the tracking and subsequent vertex information within a short latency ensures robust selections and allows improved trigger performance for the most difficult signatures, such as b-jets and τ leptons.

  5. Chemical constituents in n-butanol fractions of Castus afer ker Gawl leaf and stem

    PubMed Central

    Anyasor, Godswill Nduka; Funmilayo, Onajobi; Odutola, Osilesi; Olugbenga, Adebawo; Oboutor, Efere Martins

    2014-01-01

    Aim: This study was designed to investigate the bioactive compounds in Costus afer Ker Gawl, an indigenous African medicinal plant whose leaf and stem extracts are used in the treatment of chronic inflammatory diseases, especially rheumatism and arthritis. Materials and Methods: The bioactive compounds present in the n-butanol fractions of C. afer leaf and stem were identified using qualitative phytochemical evaluation and gas chromatography-mass spectrometry (GC/MS) analytical method, comparing the mass spectra of the identified compounds with those of the National Institute of Standards and Technology database library. Results: Qualitative analysis detected alkaloids, saponins, diterpenes, triterpenes, phytosterol, phlobatannins, and tannins in both n-butanol fractions of C. afer leaf and stem. Phenols were detected in leaves alone while flavonoids were present in stem alone. GC/MS data showed that the bioactive compounds in n-butanol fraction of C. afer leaf were indolizine, 2-methoxy-4 vinylphenol, phytol, hexadecanoic acid-methyl ester, n-hexadecanoic acid, 9,12-octadecanoic acid-methyl ester, eicosane, cis-vaccenic acid and oleic acid while n-butanol fraction of C. afer stem contain benzofuran,2,3-dihydro,2-methoxy-4 vinylphenol, 9-octadecenoic acid (Z)-2-hydroxy-1-(hydroxymethyl) ethyl ester, campesterol, stigmasterol, hexadecanoic acid-methyl ester, n-hexadecanoic acid, and cis-vaccenic acid. Conclusion: The bioactive compounds identified in the n-butanol fractions of C. afer leaves and stem may explain the folkloric use of C. afer plant in the treatment of chronic inflammatory and oxidative stress related diseases. PMID:26401352

  6. Known unknowns, Google Earth, plate tectonics and Mt Bellenden Ker: some thoughts on locality data.

    PubMed

    Mesibov, Robert

    2012-01-01

    Latitude/longitude data in locality records should be published with spatial uncertainties, datum(s) used and indications of how the data were obtained. Google Earth can be used to locate sampling sites, but the underlying georegistration of the satellite image should be checked. The little-known relabelling of a set of landmarks on Mt Bellenden Ker, a scientifically important collecting locality in tropical north Queensland, Australia, is documented as an example of the importance of checking records not accompanied by appropriately accurate latitude/longitude data. PMID:23275756

  7. Known unknowns, Google Earth, plate tectonics and Mt Bellenden Ker: some thoughts on locality data

    PubMed Central

    Mesibov, Robert

    2012-01-01

    Abstract Latitude/longitude data in locality records should be published with spatial uncertainties, datum(s) used and indications of how the data were obtained. Google Earth can be used to locate sampling sites, but the underlying georegistration of the satellite image should be checked. The little-known relabelling of a set of landmarks on Mt Bellenden Ker, a scientifically important collecting locality in tropical north Queensland, Australia, is documented as an example of the importance of checking records not accompanied by appropriately accurate latitude/longitude data. PMID:23275756

  8. Known unknowns, Google Earth, plate tectonics and Mt Bellenden Ker: some thoughts on locality data.

    PubMed

    Mesibov, Robert

    2012-01-01

    Latitude/longitude data in locality records should be published with spatial uncertainties, datum(s) used and indications of how the data were obtained. Google Earth can be used to locate sampling sites, but the underlying georegistration of the satellite image should be checked. The little-known relabelling of a set of landmarks on Mt Bellenden Ker, a scientifically important collecting locality in tropical north Queensland, Australia, is documented as an example of the importance of checking records not accompanied by appropriately accurate latitude/longitude data.

  9. Association football and the representation of homosexuality by the print media: a case study of Anton Hysén.

    PubMed

    Cleland, Jamie

    2014-01-01

    In March 2011, Anton Hysén (a semiprofessional footballer currently playing in the Swedish fourth division) became only the second association football (soccer) player of any professional disposition to publicly declare his homosexuality while still playing the game. This article provides a textual analysis of the print media's reaction to Hysén coming out and examines whether, in 2011, they portray more inclusive notions toward homosexuality than they did in 1990 when British footballer Justin Fashanu came out. The results advance inclusive masculinity theory as a number of print media sources (mostly British) interview Hysén in the weeks immediately after he came out and publish articles that challenge homophobia. Highlighting a change since 1990, a significant number of articles stress the need for the key stakeholders in football (players, fans, clubs, agents, the authorities, and the media) to accept gay players.

  10. [Anton Ritter von Frisch (1849-1917): life and work of the first President of the German Society of Urology].

    PubMed

    Hatzinger, M

    2011-06-01

    Professor Dr. Anton Ritter von Frisch was born in Vienna on 16 February 1849 where he was appointed Head of the Special Department for Diseases of the Urinary Organs at the General Polyclinic in 1889. Numerous publications and textbooks on urology can be attributed to him. From a historical perspective, he is particularly distinguished by the fact that he was elected as the first President of the German Society of Urology in 1907 in Vienna and was even designated to become President for a second time for the 1915 Congress, which however was never organized due to the outbreak of World War I. His early death in 1917 at the age of only 68 brought an end to his exceptionally productive and successful efforts on the part of urology. PMID:21559916

  11. Association football and the representation of homosexuality by the print media: a case study of Anton Hysén.

    PubMed

    Cleland, Jamie

    2014-01-01

    In March 2011, Anton Hysén (a semiprofessional footballer currently playing in the Swedish fourth division) became only the second association football (soccer) player of any professional disposition to publicly declare his homosexuality while still playing the game. This article provides a textual analysis of the print media's reaction to Hysén coming out and examines whether, in 2011, they portray more inclusive notions toward homosexuality than they did in 1990 when British footballer Justin Fashanu came out. The results advance inclusive masculinity theory as a number of print media sources (mostly British) interview Hysén in the weeks immediately after he came out and publish articles that challenge homophobia. Highlighting a change since 1990, a significant number of articles stress the need for the key stakeholders in football (players, fans, clubs, agents, the authorities, and the media) to accept gay players. PMID:24871942

  12. 4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments.

    PubMed

    Raviram, Ramya; Rocha, Pedro P; Müller, Christian L; Miraldi, Emily R; Badri, Sana; Fu, Yi; Swanzey, Emily; Proudhon, Charlotte; Snetkova, Valentina; Bonneau, Richard; Skok, Jane A

    2016-03-01

    4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a single locus of interest (or "bait") that can be important for gene regulation. However, analysis of 4C-Seq data is complicated by the many biases inherent to the technique. An important consideration when dealing with 4C-Seq data is the differences in resolution of signal across the genome that result from differences in 3D distance separation from the bait. This leads to the highest signal in the region immediately surrounding the bait and increasingly lower signals in far-cis and trans. Another important aspect of 4C-Seq experiments is the resolution, which is greatly influenced by the choice of restriction enzyme and the frequency at which it can cut the genome. Thus, it is important that a 4C-Seq analysis method is flexible enough to analyze data generated using different enzymes and to identify interactions across the entire genome. Current methods for 4C-Seq analysis only identify interactions in regions near the bait or in regions located in far-cis and trans, but no method comprehensively analyzes 4C signals of different length scales. In addition, some methods also fail in experiments where chromatin fragments are generated using frequent cutter restriction enzymes. Here, we describe 4C-ker, a Hidden-Markov Model based pipeline that identifies regions throughout the genome that interact with the 4C bait locus. In addition, we incorporate methods for the identification of differential interactions in multiple 4C-seq datasets collected from different genotypes or experimental conditions. Adaptive window sizes are used to correct for differences in signal coverage in near-bait regions, far-cis and trans chromosomes. Using several datasets, we demonstrate that 4C-ker outperforms all existing 4C-Seq pipelines in its ability to reproducibly identify interaction domains at all genomic ranges with different resolution enzymes.

  13. In the shadow of Darwin: Anton de Bary's origin of myxomycetology and a molecular phylogeny of the plasmodial slime molds.

    PubMed

    Hoppe, T; Kutschera, U

    2010-06-01

    In his Origin of Species (John Murray, London, 1859), Charles Darwin described the theory of descent with modification by means of natural selection and postulated that all life may have evolved from one or a few simple kinds of organisms. However, Darwin's concept of evolutionary change is entirely based on observations of populations of animals and plants. He briefly mentioned 'lower algae', but ignored amoebae, bacteria and other micro-organisms. In 1859, Anton de Bary, the founder of mycology and plant pathology, published a seminal paper on the biology and taxonomy of the plasmodial slime molds (myxomycetes). These heterotrophic protists are known primarily as a large composite mass, the plasmodium, in which single nuclei are suspended in a common 'naked' cytoplasm that is surrounded by a plasma membrane. Here we summarize the contents of de Bary's 1859 publication and highlight the significance of this scientific classic with respect to the establishment of the kingdom Protoctista (protists such as amoebae), the development of the protoplasmic theory of the cell, the introduction of the concept of symbiosis and the rejection of the dogma of spontaneous generation. We describe the life cycle of the myxomycetes, present new observations on the myxamoebae and propose a higher-order phylogeny based on elongation factor-1 alpha gene sequences. Our results document the congruence between the morphology-based taxonomy of the myxomycetes and molecular data. In addition, we show that free-living amoebae, common protists in the soil, are among the closest living relatives of the myxomycetes and conclude that de Bary's 'Amoeba-hypothesis' on the evolutionary origin of the plasmodial slime molds may have been correct.

  14. In the shadow of Darwin: Anton de Bary's origin of myxomycetology and a molecular phylogeny of the plasmodial slime molds.

    PubMed

    Hoppe, T; Kutschera, U

    2010-06-01

    In his Origin of Species (John Murray, London, 1859), Charles Darwin described the theory of descent with modification by means of natural selection and postulated that all life may have evolved from one or a few simple kinds of organisms. However, Darwin's concept of evolutionary change is entirely based on observations of populations of animals and plants. He briefly mentioned 'lower algae', but ignored amoebae, bacteria and other micro-organisms. In 1859, Anton de Bary, the founder of mycology and plant pathology, published a seminal paper on the biology and taxonomy of the plasmodial slime molds (myxomycetes). These heterotrophic protists are known primarily as a large composite mass, the plasmodium, in which single nuclei are suspended in a common 'naked' cytoplasm that is surrounded by a plasma membrane. Here we summarize the contents of de Bary's 1859 publication and highlight the significance of this scientific classic with respect to the establishment of the kingdom Protoctista (protists such as amoebae), the development of the protoplasmic theory of the cell, the introduction of the concept of symbiosis and the rejection of the dogma of spontaneous generation. We describe the life cycle of the myxomycetes, present new observations on the myxamoebae and propose a higher-order phylogeny based on elongation factor-1 alpha gene sequences. Our results document the congruence between the morphology-based taxonomy of the myxomycetes and molecular data. In addition, we show that free-living amoebae, common protists in the soil, are among the closest living relatives of the myxomycetes and conclude that de Bary's 'Amoeba-hypothesis' on the evolutionary origin of the plasmodial slime molds may have been correct. PMID:19997788

  15. 4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments

    PubMed Central

    Raviram, Ramya; Rocha, Pedro P.; Müller, Christian L.; Miraldi, Emily R.; Badri, Sana; Fu, Yi; Swanzey, Emily; Proudhon, Charlotte; Snetkova, Valentina

    2016-01-01

    4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a single locus of interest (or “bait”) that can be important for gene regulation. However, analysis of 4C-Seq data is complicated by the many biases inherent to the technique. An important consideration when dealing with 4C-Seq data is the differences in resolution of signal across the genome that result from differences in 3D distance separation from the bait. This leads to the highest signal in the region immediately surrounding the bait and increasingly lower signals in far-cis and trans. Another important aspect of 4C-Seq experiments is the resolution, which is greatly influenced by the choice of restriction enzyme and the frequency at which it can cut the genome. Thus, it is important that a 4C-Seq analysis method is flexible enough to analyze data generated using different enzymes and to identify interactions across the entire genome. Current methods for 4C-Seq analysis only identify interactions in regions near the bait or in regions located in far-cis and trans, but no method comprehensively analyzes 4C signals of different length scales. In addition, some methods also fail in experiments where chromatin fragments are generated using frequent cutter restriction enzymes. Here, we describe 4C-ker, a Hidden-Markov Model based pipeline that identifies regions throughout the genome that interact with the 4C bait locus. In addition, we incorporate methods for the identification of differential interactions in multiple 4C-seq datasets collected from different genotypes or experimental conditions. Adaptive window sizes are used to correct for differences in signal coverage in near-bait regions, far-cis and trans chromosomes. Using several datasets, we demonstrate that 4C-ker outperforms all existing 4C-Seq pipelines in its ability to reproducibly identify interaction domains at all genomic ranges with different resolution enzymes. PMID:26938081

  16. Improved catalytic efficiency, thermophilicity, anti-salt and detergent tolerance of keratinase KerSMD by partially truncation of PPC domain

    PubMed Central

    Fang, Zhen; Zhang, Juan; Du, Guocheng; Chen, Jian

    2016-01-01

    The keratinase from Stenotrophomonas maltophilia (KerSMD) is known for its high activity and pH stability in keratin degradation. However, catalytic efficiency and detergent tolerability need to be improved in order to be used for industrial application. In this work, we obtained several keratinase variants with enhanced catalytic efficiency, thermophilicity, and anti-salt and detergent tolerability by partially truncating the PPC domain of KerSMD. The variants all showed improved catalytic efficiency to synthetic substrate AAPF, with the V355 variant having the highest kcat /Km value of 143.6 s−1 mM−1. The truncation of keratinase had little effect on alkaline stability but obviously decreased collagenase activity, developing its potential application in leather treatment. The variants V380, V370, and V355 were thermophilic, with a 1.7-fold enhancement of keratinlytic activity at 60 °C when compared to the wild type. The entire truncation of PPC domain obtained the variant V355 with improved tolerance to alkalinity, salt, chaotropic agents, and detergents. The V355 variant showed more than a 40% improvement in activity under 15% (w/v) NaCl or 4% (w/v) SDS solution, showing excellent stability under harsh washing and unhairing conditions. Our work investigated how protein engineering affects the function of PPC domain of KerSMD. PMID:27298079

  17. Improved catalytic efficiency, thermophilicity, anti-salt and detergent tolerance of keratinase KerSMD by partially truncation of PPC domain.

    PubMed

    Fang, Zhen; Zhang, Juan; Du, Guocheng; Chen, Jian

    2016-01-01

    The keratinase from Stenotrophomonas maltophilia (KerSMD) is known for its high activity and pH stability in keratin degradation. However, catalytic efficiency and detergent tolerability need to be improved in order to be used for industrial application. In this work, we obtained several keratinase variants with enhanced catalytic efficiency, thermophilicity, and anti-salt and detergent tolerability by partially truncating the PPC domain of KerSMD. The variants all showed improved catalytic efficiency to synthetic substrate AAPF, with the V355 variant having the highest kcat /Km value of 143.6 s(-1) mM(-1). The truncation of keratinase had little effect on alkaline stability but obviously decreased collagenase activity, developing its potential application in leather treatment. The variants V380, V370, and V355 were thermophilic, with a 1.7-fold enhancement of keratinlytic activity at 60 °C when compared to the wild type. The entire truncation of PPC domain obtained the variant V355 with improved tolerance to alkalinity, salt, chaotropic agents, and detergents. The V355 variant showed more than a 40% improvement in activity under 15% (w/v) NaCl or 4% (w/v) SDS solution, showing excellent stability under harsh washing and unhairing conditions. Our work investigated how protein engineering affects the function of PPC domain of KerSMD. PMID:27298079

  18. Investigations of the methanolic leaf extract of Costus afer. Ker for pharmacological activities in vitro and in vivo.

    PubMed

    Anaga, A O; Njoku, C J; Ekejiuba, E S; Esiaka, M N; Asuzu, I U

    2004-02-01

    The methanolic leaf extract of Costus afer. Ker (family: Zingiberaceae) was investigated for some pharmacological effects in vivo and in vitro. Brine shrimp lethality test showed that the extract was significantly (p < 0.05) cytotoxic with LC50 of 21.3 ppm. The extract showed moderate local anesthetic property, about twice less than lignocaine of the same concentration, on guinea pig wheal test. The extract contracted the guinea pig ileum in a concentration-dependent manner, but had no effect on pleuripara and nullipara non-gravid uteri at progestogenic and estrogenic phases respectively. The contractile effect on the guinea pig ileum was partially inhibited by atropine but completely reversed by adrenaline. The extract induced expulsion of whole fetuses still enveloped within the placental membrane at the 3rd trimester of pregnancy. The extract exhibited a biphasic antihyperglycemic activity. At 200 mg/kg body wt., p.o., it decreased the blood glucose level by 50% in Streptozotocin-induced hyperglycemia in male rats in 60 minutes post dosing. However, doses above 200 mg/kg body wt., p.o., caused increase in blood glucose level, potentiating the action of STZ. At 10 microg/ml the extract induced about 98% glucose uptake in differentiated 3T3-L1 adipocytes when compared with insulin (340 nm). PMID:15070179

  19. The combination of atomic force microscopy and sugar analysis to evaluate alkali-soluble Canna edulis Ker pectin.

    PubMed

    Zhang, Juan; Cui, Junhui; Xiao, Lin; Wang, Zhengwu

    2014-08-01

    Alkali-soluble pectin, which has been extracted from Canna edulis Ker, was characterized by single sugar determination and atomic force microscopy (AFM). The results indicated that the amounts of four predominant sugars including arabinose (Ara), glucose (Glc), galactose (Gal) and galacturonic acid (GalA) significantly decreased during the process of mild acid hydrolysis. The decreasing rates of these four sugars followed a sequential order of Ara>Gal>Glc>GalA. The homogalacturonan (HG) chain present in pectin, and the quantity of branched material is greater than the sample containing the main neutral sugars. The results indicated that the neutral sugar and HG side chains are attached to pectin as part of the rhamnogalacturonan I (RGI) complex. Moreover, hydrolysis leads to the reduction of mean lengths of backbone and branch, as well as the number/weight-average molecular weight. Meanwhile, the amount of short chain fractions increased during hydrolysis. Furthermore, the decrease of the polymerization degree of alkali-soluble C. edulis pectin as a function of the hydrolysis time could be described by a first-order exponential decay function.

  20. Anton permselective membrane

    NASA Technical Reports Server (NTRS)

    Alexander, S. S.; Hodgdon, R. B.; Waite, W. A.

    1979-01-01

    Experimental composite membranes were synthesized on a lab scale consisting of a thin layer of anion permselective resin supported by and bonded to a porous physically strong and conductive substrate film. These showed good selectivity and also substantially lower electrical resistivities than the homogenous candidate membranes optimized in the previous contract. A wide range of resin porosities were examined for three candidate membrane systems, CDIL, CP4L, and A3L to identify the formulation giving the best overall redox cell performance. Candidate anion membranes showed large increases in resistivity after a short time of immersion in concentrated FeCl/HCl solution. Largely on the basis of resistance stability the CDIL formulation was selected as prime candidate and about thirty-five membranes (one foot square) were produced for experimental static and dynamic evaluation.

  1. The hybrid expert in the 'bergstaat': Anton von Ruprecht as a professor of chemistry and mining and as a mining official, 1779-1814.

    PubMed

    Konecný, Peter

    2012-07-01

    In the course of the 18th century a new type of scientifically educated functional elites developed, who were trained to administer mines. The educational project that led to the formation of a corps of mining engineers was part of a programme of administrative and economic reforms that led to a new configuration of bonds between state, economy and science. At the same time the status of this new group of experts was predicated substantially by the new emerging corpora of the scientific, technological and cameralist knowledge of the period between 1760 and 1800. The aim of this paper is to discuss this group using the example of a leading expert in the context of the mining and metallurgy of this period. Anton von Ruprecht (1748-1814) was strongly grounded in the social and epistemic context of the Habsburg mining bureaucracy, which employed his scientific and technical savoir faire to serve their mercantile goals in several areas of mining expertise.

  2. [The attempts at drug therapy of cancer by Anton Störck (1731-1803). History of experimental pharmacology in the old Vienna Medical School].

    PubMed

    Schweppe, K W; Probst, C

    1982-03-15

    The essay deals with the development of medical research in Vienna - especially the development of therapeutic drugs. This progress is related to the philosophical, historical, and political background of the enlightened absolutism and the reformatory efforts of van Swieten during the regency of Maria Theresia in Austria. Anton Störck's research on hemlock (Conium maculatum) is used as an example. The method of Störck's research-work is described. Furthermore it is demonstrated to what extent Störck's data, deduced from empirical examinations, are integrated in the official medical system, i.e. Boerhaave's iatromechanic system. Finally the attempt is made to correlate these processes of medical history with the scientific-historical model of Thomas Kuhn.

  3. [The attempts at drug therapy of cancer by Anton Störck (1731-1803). History of experimental pharmacology in the old Vienna Medical School].

    PubMed

    Schweppe, K W; Probst, C

    1982-03-15

    The essay deals with the development of medical research in Vienna - especially the development of therapeutic drugs. This progress is related to the philosophical, historical, and political background of the enlightened absolutism and the reformatory efforts of van Swieten during the regency of Maria Theresia in Austria. Anton Störck's research on hemlock (Conium maculatum) is used as an example. The method of Störck's research-work is described. Furthermore it is demonstrated to what extent Störck's data, deduced from empirical examinations, are integrated in the official medical system, i.e. Boerhaave's iatromechanic system. Finally the attempt is made to correlate these processes of medical history with the scientific-historical model of Thomas Kuhn. PMID:7043908

  4. Benthic Assemblages of the Anton Dohrn Seamount (NE Atlantic): Defining Deep-Sea Biotopes to Support Habitat Mapping and Management Efforts with a Focus on Vulnerable Marine Ecosystems

    PubMed Central

    Davies, Jaime S.; Stewart, Heather A.; Narayanaswamy, Bhavani E.; Jacobs, Colin; Spicer, John; Golding, Neil; Howell, Kerry L.

    2015-01-01

    In 2009 the NW and SE flanks of Anton Dohrn Seamount were surveyed using multibeam echosounder and video ground-truthing to characterise megabenthic biological assemblages (biotopes) and assess those which clearly adhere to the definition of Vulnerable Marine Ecosystems, for use in habitat mapping. A combination of multivariate analysis of still imagery and video ground-truthing defined 13 comprehensive descriptions of biotopes that function as mapping units in an applied context. The data reveals that the NW and SE sides of Anton Dohrn Seamount (ADS) are topographically complex and harbour diverse biological assemblages, some of which agree with current definitions of ‘listed’ habitats of conservation concern. Ten of these biotopes could easily be considered Vulnerable Marine Ecosystems; three coral gardens, four cold-water coral reefs, two xenophyophore communities and one sponge dominated community, with remaining biotopes requiring more detailed assessment. Coral gardens were only found on positive geomorphic features, namely parasitic cones and radial ridges, found both sides of the seamount over a depth of 1311–1740 m. Two cold-water coral reefs (equivalent to summit reef) were mapped on the NW side of the seamount; Lophelia pertusa reef associated with the cliff top mounds at a depth of 747–791 m and Solenosmilia variabilis reef on a radial ridge at a depth of 1318-1351 m. Xenophyophore communities were mapped from both sides of the seamount at a depth of 1099–1770 m and were either associated with geomorphic features or were in close proximity (< 100 m) to them. The sponge dominated community was found on the steep escarpment either side of the seamount over at a depth of 854-1345 m. Multivariate diversity revealed the xenophyophore biotopes to be the least diverse, and a hard substratum biotope characterised by serpulids and the sessile holothurian, Psolus squamatus, as the most diverse. PMID:25992572

  5. Benthic Assemblages of the Anton Dohrn Seamount (NE Atlantic): Defining Deep-Sea Biotopes to Support Habitat Mapping and Management Efforts with a Focus on Vulnerable Marine Ecosystems.

    PubMed

    Davies, Jaime S; Stewart, Heather A; Narayanaswamy, Bhavani E; Jacobs, Colin; Spicer, John; Golding, Neil; Howell, Kerry L

    2015-01-01

    In 2009 the NW and SE flanks of Anton Dohrn Seamount were surveyed using multibeam echosounder and video ground-truthing to characterise megabenthic biological assemblages (biotopes) and assess those which clearly adhere to the definition of Vulnerable Marine Ecosystems, for use in habitat mapping. A combination of multivariate analysis of still imagery and video ground-truthing defined 13 comprehensive descriptions of biotopes that function as mapping units in an applied context. The data reveals that the NW and SE sides of Anton Dohrn Seamount (ADS) are topographically complex and harbour diverse biological assemblages, some of which agree with current definitions of 'listed' habitats of conservation concern. Ten of these biotopes could easily be considered Vulnerable Marine Ecosystems; three coral gardens, four cold-water coral reefs, two xenophyophore communities and one sponge dominated community, with remaining biotopes requiring more detailed assessment. Coral gardens were only found on positive geomorphic features, namely parasitic cones and radial ridges, found both sides of the seamount over a depth of 1311-1740 m. Two cold-water coral reefs (equivalent to summit reef) were mapped on the NW side of the seamount; Lophelia pertusa reef associated with the cliff top mounds at a depth of 747-791 m and Solenosmilia variabilis reef on a radial ridge at a depth of 1318-1351 m. Xenophyophore communities were mapped from both sides of the seamount at a depth of 1099-1770 m and were either associated with geomorphic features or were in close proximity (< 100 m) to them. The sponge dominated community was found on the steep escarpment either side of the seamount over at a depth of 854-1345 m. Multivariate diversity revealed the xenophyophore biotopes to be the least diverse, and a hard substratum biotope characterised by serpulids and the sessile holothurian, Psolus squamatus, as the most diverse. PMID:25992572

  6. Benthic Assemblages of the Anton Dohrn Seamount (NE Atlantic): Defining Deep-Sea Biotopes to Support Habitat Mapping and Management Efforts with a Focus on Vulnerable Marine Ecosystems.

    PubMed

    Davies, Jaime S; Stewart, Heather A; Narayanaswamy, Bhavani E; Jacobs, Colin; Spicer, John; Golding, Neil; Howell, Kerry L

    2015-01-01

    In 2009 the NW and SE flanks of Anton Dohrn Seamount were surveyed using multibeam echosounder and video ground-truthing to characterise megabenthic biological assemblages (biotopes) and assess those which clearly adhere to the definition of Vulnerable Marine Ecosystems, for use in habitat mapping. A combination of multivariate analysis of still imagery and video ground-truthing defined 13 comprehensive descriptions of biotopes that function as mapping units in an applied context. The data reveals that the NW and SE sides of Anton Dohrn Seamount (ADS) are topographically complex and harbour diverse biological assemblages, some of which agree with current definitions of 'listed' habitats of conservation concern. Ten of these biotopes could easily be considered Vulnerable Marine Ecosystems; three coral gardens, four cold-water coral reefs, two xenophyophore communities and one sponge dominated community, with remaining biotopes requiring more detailed assessment. Coral gardens were only found on positive geomorphic features, namely parasitic cones and radial ridges, found both sides of the seamount over a depth of 1311-1740 m. Two cold-water coral reefs (equivalent to summit reef) were mapped on the NW side of the seamount; Lophelia pertusa reef associated with the cliff top mounds at a depth of 747-791 m and Solenosmilia variabilis reef on a radial ridge at a depth of 1318-1351 m. Xenophyophore communities were mapped from both sides of the seamount at a depth of 1099-1770 m and were either associated with geomorphic features or were in close proximity (< 100 m) to them. The sponge dominated community was found on the steep escarpment either side of the seamount over at a depth of 854-1345 m. Multivariate diversity revealed the xenophyophore biotopes to be the least diverse, and a hard substratum biotope characterised by serpulids and the sessile holothurian, Psolus squamatus, as the most diverse.

  7. [The Essen-based steel producer Alfred Krupp (1812-1887) as a reader of the flora and fauna of the Gulf of Naples. A look at the relationship of Anton Dohrn (1840-1909) to the house Krupp].

    PubMed

    Müller, Irmgard

    2015-01-01

    A unfavourable notice written by industrial magnate Alfred Krupp (1812-1887) has been discovered on the posterior cover sheet of the first volume of the monumental series Fauna und Flora des Golfes von Neapel, edited by the Zoological Station at Naples (1880) Krupp's handwritten statement affords the opportunity to discuss in more detail the intricate relationship between the founder of the first marine biology station, Anton Dohrn (1840-1909), and the owner of the greatest steel factory in Europe, the Krupp-family at Essen. Although Anton Dohrn did not know about Krupp's disapproving comment he had a fine unerring instinct for the mentality of his negotiating partner, whose way of thinking rather aimed at the practical success and completion of armament factory, preventing thus a the serious rapprochement between the two personalities. Even when the Krupp-heir, Friedrich Alfred Krupp, later devoted to questions about marine biology in his new built house at Capri, and was willing to support the Zoological Station with high sponsoring, Anton Dohrn maintained a reserved attitude towards the Krupp's offer to support the marine research financially. Likewise, he remained unimpressed, when the steel magnate was shook by the smear campaign in Capri that ultimately led to Krupp's death in November 1902. PMID:25515144

  8. [The Essen-based steel producer Alfred Krupp (1812-1887) as a reader of the flora and fauna of the Gulf of Naples. A look at the relationship of Anton Dohrn (1840-1909) to the house Krupp].

    PubMed

    Müller, Irmgard

    2015-01-01

    A unfavourable notice written by industrial magnate Alfred Krupp (1812-1887) has been discovered on the posterior cover sheet of the first volume of the monumental series Fauna und Flora des Golfes von Neapel, edited by the Zoological Station at Naples (1880) Krupp's handwritten statement affords the opportunity to discuss in more detail the intricate relationship between the founder of the first marine biology station, Anton Dohrn (1840-1909), and the owner of the greatest steel factory in Europe, the Krupp-family at Essen. Although Anton Dohrn did not know about Krupp's disapproving comment he had a fine unerring instinct for the mentality of his negotiating partner, whose way of thinking rather aimed at the practical success and completion of armament factory, preventing thus a the serious rapprochement between the two personalities. Even when the Krupp-heir, Friedrich Alfred Krupp, later devoted to questions about marine biology in his new built house at Capri, and was willing to support the Zoological Station with high sponsoring, Anton Dohrn maintained a reserved attitude towards the Krupp's offer to support the marine research financially. Likewise, he remained unimpressed, when the steel magnate was shook by the smear campaign in Capri that ultimately led to Krupp's death in November 1902.

  9. Monte Carlo studies of the magnetic phase diagram of KEr(MoO4)2: A dipolar magnet with strong tetragonal distortion

    NASA Astrophysics Data System (ADS)

    Orendáčová, A.; Horváth, D.; Orendáč, M.; Čižmár, E.; Kačmár, M.; Bondarenko, V.; Anders, A. G.; Feher, A.

    2002-01-01

    The magnetic phase diagram of KEr(MoO4)2 a dipolar magnetic system with strong tetragonal distortion is investigated. The analysis of the experimental results indicates that the dipolar magnet with strong tetragonal distortion in external magnetic field applied along the easy axis resembles the behavior of the S=1/2 two-dimensional Ising model on the rectangular lattice in B||z with the nearest neighbor interactions only. The Monte Carlo studies of the corresponding critical Bc-Tc line revealed the second order character of the phase transitions down to the critical temperature ~0.7 K and critical field Bc~50 mT. The behavior of experimental and numerical data at lower critical temperatures suggests the vicinity of a tricritical point TT characteristic for metamagnets.

  10. The EDRO Board Connected to the Associative Memory: a “Baby” FastTracKer Processor for the ATLAS Experiment

    NASA Astrophysics Data System (ADS)

    Annovi, A.; Beretta, M.; Bevacqua, V.; Cervigni, F.; Crescioli, F.; Fabbri, L.; Giannetti, P.; Giorgi, F.; Magalotti, D.; Negri, A.; Piendibene, M.; Roda, C.; Sbarra, C.; Villa, M.; Vitillo, R. A.; Volpi, G.

    The FastTracKer (FTK), a hardware dedicated processor, performs fast and precise online full track reconstruction at the ATLAS experiment, within an average latency of few dozens of microseconds. Before production of the final system for tracking in high-occupancy conditions with the best of available technology, we plan to use existing prototypes of the FTK hardware to exercise its functions in the ATLAS environment. We describe the "baby FTK", consisting of a few hardware elements implementing the first stages of the system, and discuss our plans to grow the system into a full-functionality FTK "vertical slice" covering a small projective wedge of the detector. We report on the performances and structure of the "baby FTK", including the pixel/strip hit clustering (clustering mezzanine), hit organization and distribution (EDRO) and the Associative Memory pattern recognition function. We describe briefly also the possible future evolution including the addition of the Track Fitter.

  11. [Anton Nyström: the first practitioner in dermatology in Sweden and the controversy about his book on skin disorders].

    PubMed

    Thyresson, N

    1994-01-01

    Anton Nyström (1842-1931), practitioner and author, was at the end of the nineteenth and the beginning of the twentieth century a well-known but also controversial personage in Swedish cultural and intellectual life. The posterity remembers him mainly for having introduced the philosophical system of Auguste Comte and founded a Society for Positivism in Sweden as well as having founded an institution ("Arbetarinstitutet") in Stockholm with the purpose to give an all-round education to the working classes through lectures by leading personalities in the world of culture and science. In numerous publications he treated besides medical topics also religious, cultural, social, political and historical themes. Immediately after his medical graduation in May 1868, he went abroad to study dermatology and stayed for this purpose for nearly one and a half years in Vienna, Paris and London. Back in Sweden in the autumn of 1869, he began writing a book with the title "Theoretical and practical essays on skin disorders." This book is for us today interesting because it illustrates the different views of that time on skin diseases held by Hebra in Vienna, Bazin and Hardy in Paris and Wilson and Tilbury Fox in London. In Paris Nyström had been fascinated by Bazin's and Hardy's theories on constitutional diseases and diathetic states and had, as he says, "embraced the doctrines of Bazin". In Vienna, however, he had disapproved of Hebra's way to reject speculations on internal etiology for skin diseases and to look upon them as having mainly an external cause and of his method to treat skin diseases preferably with local remedies. In London he was on very friendly terms with Tilbury Fox, who to his satisfaction also sympathized with the opinions held by Bazin. ...

  12. [Anton Nyström: the first practitioner in dermatology in Sweden and the controversy about his book on skin disorders].

    PubMed

    Thyresson, N

    1994-01-01

    Anton Nyström (1842-1931), practitioner and author, was at the end of the nineteenth and the beginning of the twentieth century a well-known but also controversial personage in Swedish cultural and intellectual life. The posterity remembers him mainly for having introduced the philosophical system of Auguste Comte and founded a Society for Positivism in Sweden as well as having founded an institution ("Arbetarinstitutet") in Stockholm with the purpose to give an all-round education to the working classes through lectures by leading personalities in the world of culture and science. In numerous publications he treated besides medical topics also religious, cultural, social, political and historical themes. Immediately after his medical graduation in May 1868, he went abroad to study dermatology and stayed for this purpose for nearly one and a half years in Vienna, Paris and London. Back in Sweden in the autumn of 1869, he began writing a book with the title "Theoretical and practical essays on skin disorders." This book is for us today interesting because it illustrates the different views of that time on skin diseases held by Hebra in Vienna, Bazin and Hardy in Paris and Wilson and Tilbury Fox in London. In Paris Nyström had been fascinated by Bazin's and Hardy's theories on constitutional diseases and diathetic states and had, as he says, "embraced the doctrines of Bazin". In Vienna, however, he had disapproved of Hebra's way to reject speculations on internal etiology for skin diseases and to look upon them as having mainly an external cause and of his method to treat skin diseases preferably with local remedies. In London he was on very friendly terms with Tilbury Fox, who to his satisfaction also sympathized with the opinions held by Bazin. ... PMID:11640361

  13. Use of OSL dating to establish the stratigraphic framework of Quaternary eolian sediments, Anton scarp upper trench, Northeastern Colorado High Plains, USA

    USGS Publications Warehouse

    Mahan, S.A.; Noe, D.C.; McCalpin, J.P.

    2009-01-01

    This paper contains the results of the optically stimulated luminescence (OSL) dating used to establish stratigraphic ages and relationships of eolian sediments in a trench in northeastern Colorado, USA. This trench was located in the upper face of the Anton scarp, a major topographic lineament trending NW-SE for a distance of 135 km, in anticipation of intersecting near-surface faulting. The trench was 180 m long, 4.5-6.0 m deep, and exposed 22 m of stratigraphic section, most of which dipped gently west and was truncated by gulley channeling at the face of the scarp. No direct evidence of faulting was found in the upper trench. The stratigraphy from the trench was described, mapped and dated using OSL on quartz and potassium feldspar, and 14C obtained from woody material. OSL dating identified two upper loess units as Peoria Loess and Gilman Canyon Loess, deposited between 16 and 30 ka ago. The bottom layers of the trench were substantially older, giving OSL ages in excess of 100 ka. These older ages are interpreted as underestimates, owing to saturation of the fast component of OSL. Using OSL and 14C dating, we can constrain the erosion and down cutting of the scarp face as occurring between 16 and 5.7 ka. As the trenching investigation continues in other parts of the scarp face, the results of this preliminary study will be of importance in relating the ages of the strata that underlie different parts of the scarp, and in determining whether Quaternary faulting was a mechanism that contributed to the formation of this regional geomorphic feature.

  14. Power measurements on SJ-10 kE-R windmill

    SciTech Connect

    Rasmussen, F.

    1980-03-01

    This report contains results from measurements of power output for a 10 kW, 5.65-m diameter windrose. The improvements of the Windmill during the tests are described and the yearly energy output is computed for the windmill situated at different wind locations.

  15. Materials Data on KErHSe2O9 (SG:2) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  16. Materials Data on KEr(SO4)2 (SG:14) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  17. Materials Data on KEr3F10 (SG:225) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  18. Software Reviews: "Pow! Zap! Ker-plunk! The Comic Book Maker" (Pelican Software).

    ERIC Educational Resources Information Center

    Porter, Bernajean

    1990-01-01

    Reviews the newest addition to Pelican's Creative Writing Series of instructional software, which uses the comic book format to provide a unique writing environment for satire, symbolism, sequencing, and combining text and graphics to communicate ideas. (SR)

  19. Science, evolution and natural selection: in praise of Darwin at the Stazione Zoologica Anton Dohrn of Naples.

    PubMed

    Ayala, Francisco J

    2015-01-01

    Copernicus, Galileo, Newton and other physical scientists ushered in a conception of the universe as matter in motion governed by natural laws. Their discoveries brought about a fundamental revolution, namely a commitment to the postulate that the universe obeys immanent laws that can account for natural phenomena. The workings of the universe were brought into the realm of science: explanation through natural laws. Darwin completed the Copernican revolution by extending it to the living world. Darwin demonstrated the evolution of organisms. More important yet is that he discovered natural selection, the process that explains the 'design' of organisms. The adaptations and diversity of organisms, the origin of novel and complex species, even the origin of mankind, could now be explained by an orderly process of change governed by natural laws. The origin of species and the exquisite features of organisms had previously been explained as special creations of an omniscient God. Darwin brought them into the domain of science.

  20. Science, evolution and natural selection: in praise of Darwin at the Stazione Zoologica Anton Dohrn of Naples.

    PubMed

    Ayala, Francisco J

    2015-01-01

    Copernicus, Galileo, Newton and other physical scientists ushered in a conception of the universe as matter in motion governed by natural laws. Their discoveries brought about a fundamental revolution, namely a commitment to the postulate that the universe obeys immanent laws that can account for natural phenomena. The workings of the universe were brought into the realm of science: explanation through natural laws. Darwin completed the Copernican revolution by extending it to the living world. Darwin demonstrated the evolution of organisms. More important yet is that he discovered natural selection, the process that explains the 'design' of organisms. The adaptations and diversity of organisms, the origin of novel and complex species, even the origin of mankind, could now be explained by an orderly process of change governed by natural laws. The origin of species and the exquisite features of organisms had previously been explained as special creations of an omniscient God. Darwin brought them into the domain of science. PMID:26013200

  1. Pyrostegia venusta (Ker Gawl.) Miers Crude Extract and Fractions: Prevention of Dental Biofilm Formation and Immunomodulatory Capacity

    PubMed Central

    de Sousa, Mayara Brito; Júnior, José Otávio Carrera Silva; Barbosa, Wagner Luiz Ramos; da Silva Valério, Erika; da Mata Lima, Andriele; de Araújo, Marlon Heggdorne; Muzitano, Michelle Frazão; Nakamura, Celso Vataru; de Mello, João Carlos Palazzo; Teixeira, Francisco Martins

    2016-01-01

    Background: Caries and periodontal diseases remain as important diseases in the Brazilian population. One important pathogen associated with this situation is Streptococcus mutans and other important factor is this pathogen's ability to adhere firmly to the tooth surface leading to dental biofilm formation and caries development. Objectives: Determine the antibacterial and other biological activities of P. venusta related to its potential to be used in the treatment of caries and periodontal disease. Methods: The growth inhibition by P. venusta of Streptococcus mutans, S. mitis, S. oralis and Candida albicans was determined using the broth microdilution method. In addition, the effect of the samples in adherence and reducing production of acids by S. mutans, and germ-tube formation of C. albicans was analysed. The Nitric Oxide (NO) production and cytotoxicity of P. venusta to peripheral blood mononuclear cells (PBMC) and RAW 264.7 Cell Line Murine Macrophage from Blood were assessed. Results: The crude extract (CE) and ethyl-acetate (AF) and n-butanol (BF) fractions showed antibacterial activity. The ethyl-acetate (AF) fraction showed the highest inhibition percentage against the adherence of S. mutans and C. albicans cells without budding, beyond NO production inhibition. There was not any cytotoxicity in the murine macrophages RAW 264.7 cells. Conclusion: Our results suggest that P. venusta presents potential to be used as a preliminary source of compounds that can provide helpful activity when used in prophylaxis or treatment of caries or periodontal disease. SUMMARY Biological activities of Pyrostegia venusta and its potential for use in formulations for the prevention of oral diseases. Abbreviations used: NO: Nitric oxide, PBMC: Peripheral blood mononuclear cells, CE: Crude extract, AF: Ethyl-acetate fraction, BF: n-butanol fraction, HF: Hexane fraction, WF: Water fraction, MIC: Minimum inhibitory concentration, MBC: Minimum bactericidal concentration, ATCC: American Type Culture Collection, CFU: Colony-forming units, BHI: Brain heart infusion, RPMI: Roswell Park Memorial Institute, MOPS: 3-(N-morpholino)propanesulfonic acid, DMEM: Dulbecco's modified Eagle's médium, LPS: Lipopolysacharide, MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide, OD: Optical density, AC: Acteoside, PMID:27279710

  2. Role of Erythronium americanum Ker. in Energy Flow and Nutrient Dynamics of a Northern Hardwood Forest Ecosystem.

    PubMed

    Muller, R N; Bormann, F H

    1976-09-17

    The aboveground activity of the spring herb, Erythronium americanum, is restricted to the period between snowmelt and forest canopy development. Its phenology and production capacity closely adapt the species to this temporal niche in northern deciduous forests. While E. americanum has a minor effect on energy flow, it may reduce losses of potassium and nitrogen from the ecosystem during the period of maximum removal by incorporating these elements in accumulating biomass. Later, during the summer, these nutrients are made available when the above-ground, nonperennating tissues decay.

  3. A family showing inheritance of the Anton blood group antigen AnWj and independence of AnWj from Lutheran.

    PubMed

    Poole, J; Levene, C; Bennett, M; Sela, R; van Alphen, L; Spruell, P J

    1991-12-01

    A 43-year-old Arab woman was found to be negative for the high incidence AnWj antigen and her serum contained anti-AnWj. Two of her seven siblings were also AnWj-negative, which provides evidence for the first time that the AnWj-negative phenotype may be an inherited character. Blood groups of the family, in which the parents of the proposita are consanguineous, show that AnWj is not part of the ABO, Rh, MNSs, Kell, Duffy, Kidd, Xg and, notably, Lutheran blood group systems and neither is it X or Y linked.

  4. [IPA secretary and patron--Freud's patient, financial administrator and friend. Anton von Freund's letters to Sigmund Freud (1916-1919)].

    PubMed

    Huppke, Andrea; Schröter, Michael

    2011-01-01

    Although the letters, of which numerous and lengthy excerpts are presented in this paper, have repeatedly been used by scholars, they have so far remained unpublished. There are 45 items, written between 4. 1. 1916 and 13. 7. 1919. They indicate a passionate transference to Freud, unfolding against the background of two Hungarian revolutions. After suffering a relapse of his cancer, v. Freund had several stretches of analysis with Freud. While he was better, he established two major funds: one of them allowing the foundation of the psychoanalytic publishing house, the other destined to sponsor a psychoanalytic clinic in Budapest. V. Freund helped organize the Budapest IPA congress, became a member of the "secret committee" and started to actively conduct analyses. Freud was very attached to him and felt deeply shaken by the inexorable progression of v. Freund's disease and then death in January 1920.

  5. The Hybrid Expert in the "Bergstaat": Anton Von Ruprecht as a Professor of Chemistry and Mining and as a Mining Official, 1779-1814

    ERIC Educational Resources Information Center

    Konecny, Peter

    2012-01-01

    In the course of the 18th century a new type of scientifically educated functional elites developed, who were trained to administer mines. The educational project that led to the formation of a corps of mining engineers was part of a programme of administrative and economic reforms that led to a new configuration of bonds between state, economy…

  6. In situ chromosomal localization of rDNA sites in "Safed Musli" Chlorophytum ker-gawl and their physical measurement by fiber FISH.

    PubMed

    Lavania, U C; Basu, S; Srivastava, S; Mukai, Y; Lavania, S

    2005-01-01

    Fluorescence In Situ Hybridization (FISH) technique has been applied on somatic chromosomes and extended DNA fibers in the medicinally important species of Chlorophytum to elucidate physical localization and measurement of the rDNA sites using two rRNA multigene families homologous to 45S and 5S rDNA. The two species of Chlorophytum, namely C. borivillianum and C. comosum, both with 2n = 28, reveal diversity for copy number and localization of rDNA sites. C. borivillianum is comprised of five 45S-rDNA sites:one each in the secondary constriction region of chromosomes 7, 8, 9; one in the subtelomeric region of the short arm of chromosome 2 and the telomeric region of the short arm of chromosome 12; and one 5S-rDNA site in the subtelomeric region of the long arm of chromosome 1. In C. comosum, there are three 45S-rDNA sites (one each in the short arm of chromosomes 12, 13, and 14) and two 5S-rDNA sites (in the secondary constriction regions of chromosomes 2 and 13). Fiber FISH analysis conducted on extended DNA fibers revealed variation in the size of continuous tandem strings for the two r-DNA families. Taking the standard value of native B DNA equivalent to 3.27 kb for 1 mum, it was estimated that the physical size of continuous DNA strings is of the order of approximately 90 kb, 180 kb, and 300 kb for 45S-rDNA and of the order of 60 kb, 150 kb for 5S-rDNA in C. comosum, grossly in correspondence to their respective physical sizes at metaphase.

  7. Applicability of rapid and on-site measured enzyme activity for surface water quality monitoring in an agricultural catchment

    NASA Astrophysics Data System (ADS)

    Stadler, Philipp; Farnleitner, Andreas H.; Sommer, Regina; Kumpan, Monika; Zessner, Matthias

    2014-05-01

    For the near real time and on-site detection of microbiological fecal pollution of water, the measurement of beta-D- Glucuronidase (GLUC) enzymatic activity has been suggested as a surrogate parameter and has been already successfully operated for water quality monitoring of ground water resources (Ryzinska-Paier et al. 2014). Due to possible short measure intervals of three hours, this method has high potential as a water quality monitoring tool. While cultivation based standard determination takes more than one working day (Cabral 2010) the potential advantage of detecting the GLUC activity is the high temporal measuring resolution. Yet, there is still a big gap of knowledge on the fecal indication capacity of GLUC (specificity, sensitivity, persistence, etc.) in relation to potential pollution sources and catchment conditions (Cabral 2010, Ryzinska-Paier et al. 2014). Furthermore surface waters are a big challenge for automated detection devices in a technical point of view due to the high sediment load during event conditions. This presentation shows results gained form two years of monitoring in an experimental catchment (HOAL) dominated by agricultural land use. Two enzymatic measurement devices are operated parallel at the catchment outlet to test the reproducibility and precision of the method. Data from continuous GLUC monitoring under both base flow and event conditions is compared with reference samples analyzed by standardized laboratory methods for fecal pollution detection (e.g. ISO 16649-1, Colilert18). It is shown that rapid enzymatic on-site GLUC determination can successfully be operated from a technical point of view for surface water quality monitoring under the observed catchment conditions. The comparison of enzyme activity with microbiological standard analytics reveals distinct differences in the dynamic of the signals during event conditions. Cabral J. P. S. (2010) "Water Microbiology. Bacterial Pathogens and Water" International Journal of

  8. Expedition 29 Crew Profile

    NASA Video Gallery

    The six members of Expedition 29 are profiled and interviewed. NASA astronauts Mike Fossum and Dan Burbank; JAXA astronaut Satoshi Furukawa; and cosmonauts Anton Shkaplerov and Anatoly Ivanishin di...

  9. Too Little too Soon: The Literature of Deaf Education in 17th-Century Britain (Part II).

    ERIC Educational Resources Information Center

    Hoolihan, Christopher

    1985-01-01

    The article describes the growth in literature on deaf education in 17th century Britain. Noted is the work of John Wallis, William Holder, George Dalgarno, Anton Deusing, and Johann Conrad Amman. (CL)

  10. Kinetic Energy Release dependence in the Photo Double Ionization of H2

    NASA Astrophysics Data System (ADS)

    Weber, Th.; Miyabe, S.; Belkacem, A.; McCurdy, C. W.; Lenz, U.; Jahnke, T.; Doerner, R.; Williams, J.; Landers, A.

    2012-06-01

    In the Photo Double Ionization (PDI) of hydrogen molecules with photon energies of 150eV we were able to probe the electronic two particle density as a function of the bond length, i.e. the Kinetic Energy Release (KER) of the ions, and the orientation of the molecular axis with respect to the polarization vector of the incoming ligh. We applied the COLTRIMS technique and measured two electrons and two protons in coincidence. We found a shift in the KER for σ and π transitions. While the KER is lower when the molecular axis is aligned parallel to the linear polarization vector (σ-σ), the KER for a perpendicular orientation (σ-π) is clearly higher by a little more than 1eV. Quantum mechanical ab initio calculations are able to quantify the shift in KER and the ratio for the two different transitions (β-parameter) for a broad range of photon energies (75 to 240eV). These results reflect the dependence of the σ and π amplitudes to the bond length. This shows that a simple KER measurement for horizontal and vertical polarization can be used to extract this information; it makes measuring the β-parameter as a function of KER obsolete.

  11. Controlling the formation of excited neutral D* fragments of D2 using intense ultrashort laser pulses

    NASA Astrophysics Data System (ADS)

    Feizollah, Peyman; Berry, Ben; Severt, T.; Jochim, Bethany; Zohrabi, M.; Kanaka Raju, P.; Rajput, Jyoti; Carnes, K. D.; Esry, B. D.; Ben-Itzhak, I.

    2016-05-01

    Excited neutral D* fragments (n >> 1) are produced by the interaction of strong-field laser pulses with D2 molecules. In this work, we focus on the formation of low kinetic energy release (KER) D* fragments, which are relatively unstudied, using NIR (800-nm) and UV (400-nm) laser pulses. The KER spectrum is found to be very sensitive to the laser parameters, including laser chirp. By changing the chirp of the UV laser pulses, two separate low-KER peaks are generated instead of a single peak. Moreover, the ratio between these peaks can be controlled with the chirp. Similarly, by chirping the NIR pulses, the low-KER peak is attenuated and shifted to lower energy. This work was supported by the Chemical Sciences, Geosciences, and Biosciences Division, Office of Basic Energy Sciences, Office of Science, U. S. Department of Energy. BJ was also supported in part by DOE-SCGF (DE-AC05-06OR23100).

  12. Subtilisin-γ-glutamyl transpeptidase: a novel combination as ungual enhancer for prospective topical application.

    PubMed

    Tiwary, Ekta; Gupta, Rani

    2010-12-01

    A feather degrading strain of Bacillus licheniformis ER-15 was isolated which also degraded α-keratin of hooves. A detailed analysis revealed that a novel monomeric γ-glutamyl transpeptidase (GGT(30)), a proteolytic product of heterodimeric 67 kDa γ-glutamyl transpeptidase (GGT(67)), assists subtilisin during its action on α keratin. An equimolar combination of subtilisin and GGT(30) was designated as KerN and was used as ungual enhancer for topical application. KerN was effective in releasing proteins from nail plate surface and 300 µg of enzyme could release 41 µg protein/mg of nail after 24 h treatment. Scanning electron micrograph (SEM) revealed loosening of nail matrix confirming the action of KerN on nail keratin. Drug permeation studies revealed permeation of clotrimazole through both enzymatically pretreated nail plates and also through nail plates in presence of KerN. Nearly 58% drug could be retained by nail plates after 24 h of 300 µg/mL KerN which further enhanced up to 97% by prolonging the enzyme application. The enzyme was found to be stable in presence of drug even after 72 h. Thus, KerN can be used as an additive in formulation of topical drug for onchomycosis. PMID:20572051

  13. Subtilisin-γ-glutamyl transpeptidase: a novel combination as ungual enhancer for prospective topical application.

    PubMed

    Tiwary, Ekta; Gupta, Rani

    2010-12-01

    A feather degrading strain of Bacillus licheniformis ER-15 was isolated which also degraded α-keratin of hooves. A detailed analysis revealed that a novel monomeric γ-glutamyl transpeptidase (GGT(30)), a proteolytic product of heterodimeric 67 kDa γ-glutamyl transpeptidase (GGT(67)), assists subtilisin during its action on α keratin. An equimolar combination of subtilisin and GGT(30) was designated as KerN and was used as ungual enhancer for topical application. KerN was effective in releasing proteins from nail plate surface and 300 µg of enzyme could release 41 µg protein/mg of nail after 24 h treatment. Scanning electron micrograph (SEM) revealed loosening of nail matrix confirming the action of KerN on nail keratin. Drug permeation studies revealed permeation of clotrimazole through both enzymatically pretreated nail plates and also through nail plates in presence of KerN. Nearly 58% drug could be retained by nail plates after 24 h of 300 µg/mL KerN which further enhanced up to 97% by prolonging the enzyme application. The enzyme was found to be stable in presence of drug even after 72 h. Thus, KerN can be used as an additive in formulation of topical drug for onchomycosis.

  14. Electron-impact dissociative double ionization of N2 and CO: Dependence of transition probability on impact energy

    NASA Astrophysics Data System (ADS)

    Pandey, A.; Kumar, P.; Banerjee, S. B.; Subramanian, K. P.; Bapat, B.

    2016-04-01

    We present an experimental and computational analysis of dissociative double ionization of N2 and CO molecules under electron impact. Experiments are performed at three energies, viz. 1, 3, and 5 keV, in order to observe the effect of impact energy on the dissociative ionization kinematics. We compare the kinetic energy release (KER) distributions of the charge symmetric dissociation channels of N22 + and CO2 + at these impact energies. An approximately linear trend between the transition energy and the expected KER values is inferred on the basis of the calculated potential energy curves of the dications. Experimentally, the normalized differential KER cross sections for these channels show an increasing trend in the low KER range and a decreasing trend in the high KER range as the electron-impact energy is increased. This observation indicates that the transition probability for excitation to different molecular ion states is not only a function of energy difference between the ground and excited states, but also a complicated function of the impact energy. In addition, nature of the observed trend in the differential KER cross sections differs significantly from their differential transition probability, which are calculated using inelastic collision model for fast-electron-impact case.

  15. Synthesis, structure and antimicrobial property of green composites from cellulose, wool, hair and chicken feather.

    PubMed

    Tran, Chieu D; Prosencyes, Franja; Franko, Mladen; Benzi, Gerald

    2016-10-20

    Novel composites between cellulose (CEL) and keratin (KER) from three different sources (wool, hair and chicken feather) were successfully synthesized in a simple one-step process in which butylmethylimidazolium chloride (BMIm(+)Cl(-)), an ionic liquid, was used as the sole solvent. The method is green and recyclable because [BMIm(+)Cl(-)] used was recovered for reuse. Spectroscopy (FTIR, XRD) and imaging (SEM) results confirm that CEL and KER remain chemically intact and homogeneously distributed in the composites. KER retains some of its secondary structure in the composites. Interestingly, the minor differences in the structure of KER in wool, hair and feather produced pronounced differences in the conformation of their corresponding composites with wool has the highest α-helix content and feather has the lowest content. These results correlate well with mechanical and antimicrobial properties of the composites. Specifically, adding CEL into KER substantially improves mechanical strength of [CEL+KER] composites made from all three different sources, wool, hair and chicken feathers i.e., [CEL+wool], [CEL+hair] and [CEL+feather]. Since mechanical strength is due to CEL, and CEL has only random structure, [CEL+feather] has, expectedly, the strongest mechanical property because feather has the lowest content of α-helix. Conversely, [CEL+wool] composite has the weakest mechanical strength because wool has the highest α-helix content. All three composites exhibit antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA). The antibacterial property is due not to CEL but to the protein and strongly depends on the type of the keratin, namely, the bactericidal effect is strongest for feather and weakest for wool. These results together with our previous finding that [CEL+KER] composites can control release of drug such as ciprofloxacin clearly indicate that these composites can potentially be used as wound dressing.

  16. Synthesis, structure and antimicrobial property of green composites from cellulose, wool, hair and chicken feather.

    PubMed

    Tran, Chieu D; Prosencyes, Franja; Franko, Mladen; Benzi, Gerald

    2016-10-20

    Novel composites between cellulose (CEL) and keratin (KER) from three different sources (wool, hair and chicken feather) were successfully synthesized in a simple one-step process in which butylmethylimidazolium chloride (BMIm(+)Cl(-)), an ionic liquid, was used as the sole solvent. The method is green and recyclable because [BMIm(+)Cl(-)] used was recovered for reuse. Spectroscopy (FTIR, XRD) and imaging (SEM) results confirm that CEL and KER remain chemically intact and homogeneously distributed in the composites. KER retains some of its secondary structure in the composites. Interestingly, the minor differences in the structure of KER in wool, hair and feather produced pronounced differences in the conformation of their corresponding composites with wool has the highest α-helix content and feather has the lowest content. These results correlate well with mechanical and antimicrobial properties of the composites. Specifically, adding CEL into KER substantially improves mechanical strength of [CEL+KER] composites made from all three different sources, wool, hair and chicken feathers i.e., [CEL+wool], [CEL+hair] and [CEL+feather]. Since mechanical strength is due to CEL, and CEL has only random structure, [CEL+feather] has, expectedly, the strongest mechanical property because feather has the lowest content of α-helix. Conversely, [CEL+wool] composite has the weakest mechanical strength because wool has the highest α-helix content. All three composites exhibit antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA). The antibacterial property is due not to CEL but to the protein and strongly depends on the type of the keratin, namely, the bactericidal effect is strongest for feather and weakest for wool. These results together with our previous finding that [CEL+KER] composites can control release of drug such as ciprofloxacin clearly indicate that these composites can potentially be used as wound dressing. PMID:27474680

  17. Cysteic Acid in Dietary Keratin is Metabolized to Glutathione and Liver Taurine in a Rat Model of Human Digestion

    PubMed Central

    Wolber, Frances M.; McGrath, Michelle; Jackson, Felicity; Wylie, Kim; Broomfield, Anne

    2016-01-01

    Poultry feathers, consisting largely of keratin, are a low-value product of the poultry industry. The safety and digestibility of a dietary protein produced from keratin (KER) was compared to a cysteine-supplemented casein-based diet in a growing rat model for four weeks. KER proved to be an effective substitute for casein at 50% of the total dietary protein, with no changes in the rats’ food intake, weight gain, organ weight, bone mineral density, white blood cell counts, liver glutathione, or blood glutathione. Inclusion of KER in the diet reduced total protein digestibility from 94% to 86% but significantly increased total dietary cysteine uptake and subsequent liver taurine levels. The KER diet also significantly increased caecum weight and significantly decreased fat digestibility, resulting in a lower proportion of body fat, and induced a significant increase in blood haemoglobin. KER is therefore a safe and suitable protein substitute for casein, and the cysteic acid in keratin is metabolised to maintain normal liver and blood glutathione levels. PMID:26907334

  18. Keratinolytic proteinase from Bacillus thuringiensis AD-12.

    PubMed

    Gegeckas, Audrius; Gudiukaitė, Renata; Citavicius, Donaldas

    2014-08-01

    A new isolated strain noted to produce a novel detergent-stable serine keratinolytic proteinase and identified as Bacillus thuringiensis AD-12. Native keratinolytic proteinase from B. thuringiensis (BtKER) was purified and characterized. The purified BtKER enzyme is a monomer with a molecular mass of 39kDa. Biochemical characterization assays revealed that the BtKER attained optimal activity at pH 7 and 30°C. Residual activity after 1h incubation at 50°C was higher than 80%. The enzyme was activated and stabilized by Mn(2+) and Li(+) metal ions but inactivated by organic solvents. Purified BtKER showed the highest substrate specificity toward keratin from wool>sodium caseinate>collagen>BSA>gelatin in descending order. BtKER is the first reported keratinolytic proteinase from B. thuringiensis and obtained results suggested that new characterized enzyme can be a powerful biocatalyst in peptide production associated to hydrolysis of keratinous and/or keratin-like waste.

  19. Renormalized second-oder perturbation theory for the electron correlation energy: concepts and benchmarks

    NASA Astrophysics Data System (ADS)

    Rinke, Patrick; Ren, Xinguo; Scheffler, Matthias; Scuseria, Gustavo

    2012-02-01

    We present a renormalized second-oder perturbation theory (R2PT) for the electron correlation energy that combines the random-phase approximation (RPA), second-order screened exchange (SOSEX) [1], and renormalized single excitations (rSE) [2]. These three terms all involve a summation of certain types of diagrams to infinite order, and can be viewed as a ``renormalization" of the direct, the exchange and the single excitation (SE) term of 2nd-order Rayleigh-Schr"ordinger perturbation theory based on an (approximate) Kohn-Sham reference state. A preliminary version of R2PT has been benchmarked for covalently-bonded molecular systems and chemical reaction barrier heights [3] and shows an overall well balanced performance. We have extended this, by including ``off-diagonal'' diagrams into the rSE term and expect this refined version of R2PT to be more generally applicable to electronic systems of different bonding characteristics. Extended benchmarks of van-der-Waals-bonded molecules and crystalline solids will be presented. [1] A. Gr"uneis et al., J. Chem. Phys. 131, 154115 (2009). [2] X. Ren et al., Phys. Rev. Lett. 106, 153003 (2011). [3] J. Paier et al., arXiv:cond-mat/1111.0173.

  20. First-principles Study of Cu2ZnSnS4 Photovoltaic Absorber

    NASA Astrophysics Data System (ADS)

    Asahi, Ryoji; Nagoya, Akihiro; Kresse, Georg

    2010-03-01

    The quaternary semiconductor Cu2ZnSnS4 (CZTS) is a relatively new photovoltaic material whose constituents are non-toxic and abundant in the earth's crust. The highest conversion efficiency reported so far is 6.7%, demanding further improvement. The key computational issue is to predict optical properties as accurate as possible, which is not possible using conventional semi-local density functionals. To this end, we have employed the Heyd-Scuseria-Ernzerhof (HSE) hybrid functional as implemented in the Vienna Ab-initio Simulation Packages (VASP) code, which allows us to obtain results in good agreement with the experimental data for the lattice constants and the band gap of CZTS [1]. We then predicted optical properties and determined the dominant optical transitions for solar-light absorption. The defect formation energies of CZTS were also calculated in the allowed range of the chemical potentials bound by the precipitation conditions of the metal-sulfides. [4pt] [1] J. Paier et al., Phys. Rev. B 79 115126 (2009).

  1. Electron Localization in Molecular Fragmentation of H{sub 2} by Carrier-Envelope Phase Stabilized Laser Pulses

    SciTech Connect

    Kremer, Manuel; Fischer, Bettina; Feuerstein, Bernold; Sharma, Vandana; Hofrichter, Christian; Schroeter, Claus Dieter; Moshammer, Robert; Ullrich, Joachim; Jesus, Vitor L. B. de; Rudenko, Artem; Thumm, Uwe

    2009-11-20

    Fully differential data for H{sub 2} dissociation in ultrashort (6 fs, 760 nm), linearly polarized, intense (0.44 PW/cm{sup 2}) laser pulses with a stabilized carrier-envelope phase (CEP) were recorded with a reaction microscope. Depending on the CEP, the molecular orientation, and the kinetic energy release (KER), we find asymmetric proton emission at low KERs (0-3 eV), basically predicted by Roudnev and Esry, and much stronger than reported by Kling et al. Wave packet propagation calculations reproduce the salient features and discard, together with the observed KER-independent electron asymmetry, the first ionization step to be the reason for the asymmetric proton emission.

  2. O2^+ dissociation caused by an ultrashort intense laser pulse

    NASA Astrophysics Data System (ADS)

    Sayler, A. M.

    2005-05-01

    Laser-induced dissociation of O2^+ has been experimentally studied with ultrashort (˜50 fs) intense (10^14 to 10^15 W/cm^2) laser pulses at 790 nm using kinematically complete coincidence 3D momentum imaging. The resulting kinetic energy release (KER) distribution has several distinct peaks, each of which has a unique angular distribution. The lower KER features are peaked around the laser polarization, while at higher KER, dissociation perpendicular to the laser polarization is significant. For comparison, a theoretical study of O2^+ dissociation using the Electron-Nuclear Dynamics (END) approach with a laser pulse included in the time-dependent dynamics is underway. Preliminary results also indicate that ionization, which occurs predominantly at the high end of the intensity range, is strongly peaked along the laser polarization.

  3. Integrative Education: Teaching Psychology with the Use of Literature and Informational Technology

    ERIC Educational Resources Information Center

    Toom, Anna

    2013-01-01

    In this work, a new method of teaching psychology based on the union of scientific, artistic, and information-technological knowledge is presented. The author teaches Cognitive Development in Early Childhood analyzing Anton Chekhov's short story "Grisha" and uses both traditional and computerized instructional methodology. In the authors' two…

  4. Effectiveness of Graduate Training in School Psychology: Perspectives of Graduate Practitioners

    ERIC Educational Resources Information Center

    Satchwell, Mary Susan

    2013-01-01

    While trends in graduate training in school psychology indicate a movement towards an increasing emphasis on consultation and decreasing emphasis on assessment (Anton-LaHart & Rosenfield, 2004), there remains a gap between training and practice for professional school psychologists (Harrison, et al., 2004). The present study provided an…

  5. York Papers in Linguistics 14.

    ERIC Educational Resources Information Center

    Harlow, S. J., Ed.; Warner, A. R., Ed.

    Papers on a variety of linguistic topics include six papers from a Festschrift and nine others, as follows: "Attitudes Towards English as a Possible Lingua Franca in Switzerland" (Urs Durmuller); "Functional Stability and Structural Levelling of Dialects: The Case of Maastricht" (Anton M. Hagen, Henk Munstermann); "On the Limits of Auditory…

  6. The Democratic School and the Pedagogy of Janusz Korczak: A Model of Early Twentieth Century Reform in Modern Israel

    ERIC Educational Resources Information Center

    Engel, Liba H.

    2013-01-01

    This article explores the history and pedagogy of Janusz Korczak within the context of his contemporary early Twentieth-Century European Innovative Educators which include Maria Montessori, Homer Lane, A.S. Neill, and Anton Semyonovitch Makarenko. The pedagogies of the aforementioned are compared and contrasted within the literature.

  7. Remembering Johann Gregor Mendel: a human, a Catholic priest, an Augustinian monk, and abbot.

    PubMed

    Richter, Father Clemens

    2015-11-01

    Johann Mendel (Gregor was the name given to him only later by his Augustinian order, Fig. 1) was born on July 20, 1822 to an ethnic German family, Anton and Rosina Mendel (Fig. 2), in Heinzendorf in the Austrian Empire at the Moravian-Silesian border (now Hynčice, Czech Republic).

  8. 17. 'BIRDSEYEVIEW, PRESIDIO OF MONTEREY, CAL., JAN. 1938.' No signature, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. 'BIRDSEYEVIEW, PRESIDIO OF MONTEREY, CAL., JAN. 1938.' No signature, photographer probably Anton C. Heidrick. This panoramic view looks west over Soldier Field from the upper floor or roof of the gymnasium. Original cool toned silver gelatin print measures 85.1 cm by 22.4 cm, flush mounted on mat board. - Presidio of Monterey, Soldier Field, Monterey, Monterey County, CA

  9. A comet in the lab

    NASA Astrophysics Data System (ADS)

    Bland, Phil A.; Kearsley, Anton T.; Wozniakiewicz, P. J.; Burchell, M. J.; Gounelle, M.; Zolensky, M. E.; Genge, Matt J.

    2007-12-01

    What have Stardust samples told us about the early solar system? Phil A Bland, Anton T Kearsley, P J Wozniakiewicz, M J Burchell, M Gounelle, M E Zolensky and Matt J Genge have some of the answers - and a few more questions.

  10. Teaching Translation and Interpreting in Slovakia: Is There Anything Other than Levý and Popovic?

    ERIC Educational Resources Information Center

    Biloveský, Vladimír; Djovcoš, Martin

    2016-01-01

    Institutional translation and interpreting training has a long lasting tradition in Slovakia mainly thanks to such significant translation scholars as Anton Popovic, František Miko, Ján Vilikovský and many others. However the situation has changed after the Velvet Revolution in 1989 and the education needed to start adapting to the new market…

  11. The Way of the Drum: When Earth Becomes Heart.

    ERIC Educational Resources Information Center

    Antone, Grafton; Turchetti, Lois Provost

    Two Native people describe their respective journeys to healing, journeys that involved the rediscovery of language and culture. In Part I, "Healing the Tears of Yesterday by the Drum Today: The Oneida Language Is a Healing Medicine" (Grafton Antone), the first narrator taught the Oneida language to adult students at a community center. Lacking…

  12. A Communicative Analysis of Chekhovian Drama as Portrayed in "The Sea Gull."

    ERIC Educational Resources Information Center

    Hellweg, John D.; Hellweg, Susan A.

    The precision and poetic logic of the language used by Anton Chekhov in his plays, particularly "The Sea Gull," can be explored through an analysis of his use of dialogue, characterization, and imagery. Measuring the nature of a relationship, rather than providing a direct literal interchange, the dialogue is both social, when individual…

  13. State of the Modern Information Professional, 1992-1993. An International View of the State of the Information Professional and the Information Profession in 1992-1993. FID Occasional Paper 4.

    ERIC Educational Resources Information Center

    International Federation for Information and Documentation, The Hague (Netherlands).

    The following 14 papers are provided: (1) "Perfil del profesional de la informacion en Venezuela" with a synopsis in English: "Profile of the Information Professional in Venezuela" (A. D. Anton and M. S. de Arenas); (2) "The Modern Information Professional in the Caribbean Setting" (D. Douglas); (3) "Development of Information Professionals and…

  14. Franklin, Lavoisier, and Mesmer: origin of the controlled clinical trial.

    PubMed

    Herr, Harry W

    2005-01-01

    In 1784, a Royal Commission headed by Benjamin Franklin and Antoine Lavoisier designed a series of ingenious experiments to debunk France's greatest medical rogue, Anton Mesmer, and his bizarre healing of illnesses based on his bogus theory of animal magnetism. Using intentional subject ignorance and sham interventions to investigate mesmerism, Franklin's commission provided a model for the controlled clinical trial. PMID:16144669

  15. Franklin, Lavoisier, and Mesmer: origin of the controlled clinical trial.

    PubMed

    Herr, Harry W

    2005-01-01

    In 1784, a Royal Commission headed by Benjamin Franklin and Antoine Lavoisier designed a series of ingenious experiments to debunk France's greatest medical rogue, Anton Mesmer, and his bizarre healing of illnesses based on his bogus theory of animal magnetism. Using intentional subject ignorance and sham interventions to investigate mesmerism, Franklin's commission provided a model for the controlled clinical trial.

  16. Remembering Johann Gregor Mendel: a human, a Catholic priest, an Augustinian monk, and abbot.

    PubMed

    Richter, Father Clemens

    2015-11-01

    Johann Mendel (Gregor was the name given to him only later by his Augustinian order, Fig. 1) was born on July 20, 1822 to an ethnic German family, Anton and Rosina Mendel (Fig. 2), in Heinzendorf in the Austrian Empire at the Moravian-Silesian border (now Hynčice, Czech Republic). PMID:26740939

  17. Charge symmetric dissociation of doubly ionized N{sub 2} and CO molecules

    SciTech Connect

    Pandey, A. Bapat, B.; Shamasundar, K. R.

    2014-01-21

    We report a comparative study of the features in dissociative double ionization by high energy electron impact of N{sub 2} and CO molecules. The ratio of cross-section of charge symmetric dissociative ionization to non-dissociative ionization (CSD-to-ND ratio) and the kinetic energy release (KER) spectra of dissociation are experimentally measured and carefully corrected for various ion transmission losses and detector inefficiencies. Given that the double ionization cross sections of these iso-electronic diatomics are very similar, the large difference in the CSD-to-ND ratios must be attributable to the differences in the evolution dynamics of the dications. To understand these differences, potential energy curves (PECs) of dications have been computed using multi-reference configuration interaction method. The Franck-Condon factors and tunneling life times of vibrational levels of dications have also been computed. While the KER spectrum of N{sub 2}{sup ++} can be readily explained by considering dissociation via repulsive states and tunneling of meta-stable states, indirect dissociation processes such as predissociation and autoionization have to be taken into account to understand the major features of the KER spectrum of CO{sup ++}. Direct and indirect processes identified on the basis of the PECs and experimental KER spectra also provide insights into the differences in the CSD-to-ND ratios.

  18. Adverse Outcome Pathway (AOP) for a Mutagenic Mode of Action for Cancer: AFB1 and Hepatocellular Carcinoma (HCC)

    EPA Science Inventory

    AOPs provide a framework to describe a sequence of measureable key events (KEs), beginning with a molecular initiating event (MIE), followed by a series of identified KEs linked to one another by KE Relationships (KERs), all anchored by a specific adverse outcome (AO). Each KE/KE...

  19. "The Road from Coorain": A Journey of Power.

    ERIC Educational Resources Information Center

    Madsen, Sandra

    "The Road from Coorain" is the autobiographical story of Jill Ker Conway, the first woman president of Smith College. The story traces Conway's journey from powerlessness to power. Born in the outback of Australia, where all people were powerless in the face of the vacillations of nature, forced off the land into a city life to which she was…

  20. Heat and Mass Transfer Modeling of Rough Rice Under Convective and Infrared Drying

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Infrared drying of rice can reduce drying time, perform disinfestations and reduce rice fissuring compared to traditional hot air drying method. Fissures in the rice kernels are caused by high moisture content gradients within the kernels. To understand the moisture distributions within a rice ker...

  1. Low Cost Real-Time Sorting of in Shell Pistachio Nuts from Kernels

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A high speed sorter for separating pistachio nuts with (in shell) and without (kernels) shells is reported. Testing indicates 95% accuracy in removing kernels from the in shell stream with no false positive results out of 1000 kernels tested. Testing with 1000 each of in shell, shell halves, and ker...

  2. Charge symmetric dissociation of doubly ionized N2 and CO molecules.

    PubMed

    Pandey, A; Bapat, B; Shamasundar, K R

    2014-01-21

    We report a comparative study of the features in dissociative double ionization by high energy electron impact of N2 and CO molecules. The ratio of cross-section of charge symmetric dissociative ionization to non-dissociative ionization (CSD-to-ND ratio) and the kinetic energy release (KER) spectra of dissociation are experimentally measured and carefully corrected for various ion transmission losses and detector inefficiencies. Given that the double ionization cross sections of these iso-electronic diatomics are very similar, the large difference in the CSD-to-ND ratios must be attributable to the differences in the evolution dynamics of the dications. To understand these differences, potential energy curves (PECs) of dications have been computed using multi-reference configuration interaction method. The Franck-Condon factors and tunneling life times of vibrational levels of dications have also been computed. While the KER spectrum of N2 (++) can be readily explained by considering dissociation via repulsive states and tunneling of meta-stable states, indirect dissociation processes such as predissociation and autoionization have to be taken into account to understand the major features of the KER spectrum of CO(++). Direct and indirect processes identified on the basis of the PECs and experimental KER spectra also provide insights into the differences in the CSD-to-ND ratios. PMID:25669391

  3. Catholic Women's Colleges in America.

    ERIC Educational Resources Information Center

    Schier, Tracy, Ed.; Russett, Cynthia, Ed.

    The chapters in this collection provide a comprehensive history of Catholic women's colleges in the United States and how they have met the challenges of broader educational change. The chapters are: (1) "Faith, Knowledge, and Gender" (Jill Ker Conway); (2) "Colleges of Religious Women's Congregations: The Spiritual Heritage" (Monika K. Hellwig);…

  4. Investigation of the ArN + 2 ion by dissociative ionization of argon/nitrogen clusters

    NASA Astrophysics Data System (ADS)

    Mähnert, Joachim; Baumgärtel, Helmut; Weitzel, Karl-Michael

    1995-01-01

    The ArN+2 ion has been investigated by means of photoionization of an argon/nitrogen cluster beam in a threshold photoelectron photoion coincidence experiment. Two pathways for the formation of ArN+2 ions have been observed: (i) the nondissociative ionization of ArN2 neutrals and (ii) the dissociative ionization of Ar2N2. The two pathways are distinguished by the kinetic energy released (KER) in the dissociative ionization. The KER for the reaction Ar2N+2→ArN+2+Ar has been measured as a function of the excitation energy. The comparison of the measured KER with the statistically expected KER allows us to extrapolate to the thermochemical threshold of the reaction under investigation. A consistent picture is obtained under two assumptions: (i) the ArN+2 ion is linear and (ii) the ionization potential of ArN2 is 14.486±0.05 eV. The former assumption is confirmed by high level ab initio calculations (QCISD/6-311G*).

  5. Detection of fungal damaged popcorn using image property covariance features

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Covariance-matrix-based features were applied to the detection of popcorn infected by a fungus that cause a symptom called “blue-eye.” This infection of popcorn kernels causes economic losses because of their poor appearance and the frequently disagreeable flavor of the popped kernels. Images of ker...

  6. The Road from Coorain.

    ERIC Educational Resources Information Center

    Conway, Jill Ker

    This autobiography is concerned with the early years and young womanhood of Jill Ker Conway, the first female president of Smith College and a noted historian specializing in the experience of women in America. The book tells the story of Conway's journey from a girlhood on an isolated sheep farm in the Australian grasslands where she studied by…

  7. Renormalized second-order perturbation theory for the electron correlation energy: Concept, implementation, and benchmarks

    NASA Astrophysics Data System (ADS)

    Ren, Xinguo; Rinke, Patrick; Scuseria, Gustavo E.; Scheffler, Matthias

    2013-07-01

    We present a renormalized second-order perturbation theory (rPT2), based on a Kohn-Sham (KS) reference state, for the electron correlation energy that includes the random-phase approximation (RPA), second-order screened exchange (SOSEX), and renormalized single excitations (rSE). These three terms all involve a summation of certain types of diagrams to infinite order, and can be viewed as ``renormalization'' of the second-order direct, exchange, and single-excitation (SE) terms of Rayleigh-Schrödinger perturbation theory based on a KS reference. In this work, we establish the concept of rPT2 and present the numerical details of our SOSEX and rSE implementations. A preliminary version of rPT2, in which the renormalized SE (rSE) contribution was treated approximately, has already been benchmarked for molecular atomization energies and chemical reaction barrier heights and shows a well-balanced performance [J. Paier , New J. Phys.1367-263010.1088/1367-2630/14/4/043002 14, 043002 (2012)]. In this work, we present a refined version of rPT2, in which we evaluate the rSE series of diagrams rigorously. We then extend the benchmark studies to noncovalent interactions, including the rare-gas dimers, and the S22 and S66 test sets, as well as the cohesive energy of small copper clusters, and the equilibrium geometry of 10 diatomic molecules. Despite some remaining shortcomings, we conclude that rPT2 gives an overall satisfactory performance across different electronic situations, and is a promising step towards a generally applicable electronic-structure approach.

  8. 2015 Annual Report of the American Psychological Association.

    PubMed

    2016-01-01

    Presents the 2015 Annual Report of the American Psychological Association. In his introduction, President Barry Anton describes how 2015 was among APA's most challenging. Although 2015 ushered in an era of greater transparency within the association and enhanced communications to members and the public, it also required painful self-reflection stemming from the revelations of an independent review by an outside law firm. The review examined the question of whether APA played any role related to the Bush administration's use of abusive interrogation techniques during the war on terror. Anton's introduction also discusses (1) the APA convention, (2) representing APA at a White House meeting with health care providers and insurance companies, (3) APA's effort to increase the number of APA-accredited internships, (4) international activities, and (5) the global summit on psychology and integrated care. (PsycINFO Database Record

  9. 2015 Annual Report of the American Psychological Association.

    PubMed

    2016-01-01

    Presents the 2015 Annual Report of the American Psychological Association. In his introduction, President Barry Anton describes how 2015 was among APA's most challenging. Although 2015 ushered in an era of greater transparency within the association and enhanced communications to members and the public, it also required painful self-reflection stemming from the revelations of an independent review by an outside law firm. The review examined the question of whether APA played any role related to the Bush administration's use of abusive interrogation techniques during the war on terror. Anton's introduction also discusses (1) the APA convention, (2) representing APA at a White House meeting with health care providers and insurance companies, (3) APA's effort to increase the number of APA-accredited internships, (4) international activities, and (5) the global summit on psychology and integrated care. (PsycINFO Database Record PMID:27504583

  10. Midwater trawl catches of adolescent and adult anguilliform fishes during the Sargasso Sea Eel Expedition 1979

    NASA Astrophysics Data System (ADS)

    Post, A.; Tesch, F.-W.

    1982-09-01

    During the research program on the biology and migration of Anguilla spp. carried out with F.R.V. “Anton Dohrn” in 1979, approximately 1300 adolescent and adult anguilliform individuals were caught covering 8 families, 10 genera and 12 species. Observations on each of these species, including horizontal and vertical distributional patterns, are dealt with herein. The appearance of various species in hauls and the absence of adult Anguilla spp. in the catches obtained are discussed.

  11. The history of Vienna University Observatory. (German Title: Die Geschichte der Universitätssternwarte Wien)

    NASA Astrophysics Data System (ADS)

    Steinmayr, Johann

    German typoscript written in 1932-1935, published here for the first time. It consists of the following chapters: The first Jesuit Observatory; The old Vienna University Observatory; History of Vienna University Observatory in the 19th century, part 1; History of Vienna University Observatory in the 19th century, part 2; Anton Pilgram and meteorological research; Serious and funny quodlibet; On instruments, measurements and finances.

  12. [Etiological research in medicine in Vienna circa 1900, at the time of Karl Landsteiner].

    PubMed

    Gröger, H

    2001-10-30

    By the end of the 19th century theoretical etiological research became more and more important in medical science. Anton Weichselbaum focused on bacteriology in the field of pathological anatomy and Rudolf Paltauf founded an Institute of Serotherapy, thus taking account of this new development. Progress made in laboratory medicine due to the work of a number of scientists in Vienna was of both fundamental and practical significance for the advancement of medicine.

  13. 16. 'EXCELLENT NEW PARADE GROUND BEST SINCE POST ESTABLISHED. STARTED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. 'EXCELLENT NEW PARADE GROUND BEST SINCE POST ESTABLISHED. STARTED BY COL. RALPH PARKER, FINISHED BY COL. TROUPE MILLER, PRESIDIO OF MONTEREY CALIFORNIA.' No date, probably ca. 1936. No signature, photographer probably Anton C. Heidrick. This panoramic view looks east over Soldier Field to the Bay, from the cannons at the west end. Original hand tinted silver gelatin print measures 90.4 cm by 20.2 cm, flush mounted on mat board. - Presidio of Monterey, Soldier Field, Monterey, Monterey County, CA

  14. Lavoisier Preempted Gay-Lussac by 20 Years!

    NASA Astrophysics Data System (ADS)

    Laing, Michael

    1998-02-01

    In his Traite E lementaire, Anton Lavoisier states clearly that exactly two volumes of hydrogen gas react with one volume of oxygen gas to yield water. One may well speculate that had he not been guillotined in 1794, Lavoisier would in all probability have deduced by 1810 that oxygen and hydrogen were diatomic. Thus atomic weights would have been correctly differentiated from equivalent weights fifty years before the Karlsruhe conference.

  15. E-Pals: Examining a Cross-Cultural Writing/Literature Project.

    ERIC Educational Resources Information Center

    McClanahan, Lauren G.

    This paper reports on a case study of a U.S. high school literature class during an e-mail exchange with a high school literature class in Moscow (Russia). During this project, the students in both classrooms read short stories by Anton Chekhov and O'Henry. By using the stories as a catalyst, the students' goal was to help their distant partner to…

  16. 14. 'TROOP A, OREGON CAVALRY IN CAMP AT PRESIDIO OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. 'TROOP A, OREGON CAVALRY IN CAMP AT PRESIDIO OF MONTEREY, CALIFORNIA, 1915.' Anton C. Heidrick, photographer. This panoramic view looks west from the lower end of Soldier Field, before construction of walls and roads. Original warm toned silver gelatin print measures 94.9 cm by 19.7 cm, flush mounted on mat board. - Presidio of Monterey, Soldier Field, Monterey, Monterey County, CA

  17. The first use of self-hypnosis: Mesmer mesmerizes Mesmer.

    PubMed

    Gravitz, M A

    1994-07-01

    Self-hypnosis is an important modern therapeutic method. This article traces its initial use in either 1778 or 1779 by Franz Anton Mesmer, the founder of animal magnetism, which, in turn, led to the present modality of hypnosis. According to a contemporary account written by a colleague, Mesmer successfully treated himself for a condition described as a blockage in the lower part of his body. He may have also taught the method of self-magnetization to others in his clinic.

  18. Equality judgments cannot distinguish between attention effects on appearance and criterion: a reply to Schneider (2011).

    PubMed

    Anton-Erxleben, Katharina; Abrams, Jared; Carrasco, Marisa

    2011-01-01

    Whether attention modulates the appearance of stimulus features is debated. Whereas many previous studies using a comparative judgment have found evidence for such an effect, two recent studies using an equality judgment have not. Critically, these studies have relied on the assumption that the equality paradigm yields bias-free PSE estimates and is as sensitive as the comparative judgment, without testing these assumptions. Anton-Erxleben, Abrams, and Carrasco (2010) compared comparative judgments and equality judgments with and without the manipulation of attention. They demonstrated that the equality paradigm is less sensitive than the comparative judgment and also bias-prone. Furthermore, they reported an effect of attention on the PSE using both paradigms. Schneider (2011) questions the validity of the latter finding, stating that the data in the equality experiment are corrupted because of skew in the response distributions. Notably, this argument supports the original conclusion by Anton-Erxleben et al.: that the equality paradigm is bias-prone. Additionally, the necessary analyses to show that the attention effect observed in Anton-Erxleben et al. was due to skew in the data were not conducted. Here, we provide these analyses and show that although the equality judgment is bias-prone, the effects we observe are consistent with an increase of apparent contrast by attention.

  19. Frequency-resolved optical gating technique for retrieving the amplitude of a vibrational wavepacket

    PubMed Central

    Nabekawa, Yasuo; Furukawa, Yusuke; Okino, Tomoya; Amani Eilanlou, A.; Takahashi, Eiji J.; Yamanouchi, Kaoru; Midorikawa, Katsumi

    2015-01-01

    We propose a novel method to determine the complex amplitude of each eigenfunction composing a vibrational wavepacket of / molecular ions evolving with a ~10 fs time scale. We find that the two-dimensional spectrogram of the kinetic energy release (KER) of H+/D+ fragments plotted against the time delay of the probe pulse is equivalent to the spectrogram used in the frequency-resolved optical gating (FROG) technique to retrieve the complex amplitude of an ultrashort optical pulse. By adapting the FROG algorithm to the delay-KER spectrogram of the vibrational wavepacket, we have successfully reconstructed the complex amplitude. The deterioration in retrieval accuracy caused by the bandpass filter required to process actual experimental data is also discussed. PMID:26068640

  20. Ultrafast Extreme Ultraviolet Induced Isomerization of Acetylene Cations

    SciTech Connect

    Jiang, Y.; Rudenko, Artem; Herrwerth, O.; Foucar, L.; Kurka, M.; Kuhnel, K.; Lezius, M.; Kling, Matthias; van Tilborg, Jeroen; Belkacem, Ali; Ueda, K.; Dusterer, S.; Treusch, R.; Schroter, Claus-Dieter; Moshammer, Robbert; Ullrich, Joachim

    2011-06-17

    Ultrafast isomerization of acetylene cations ([HC = CH]{sup +}) in the low-lying excited A{sup 2}{Sigma}{sub g}{sup +} state, populated by the absorption of extreme ultraviolet (XUV) photons (38 eV), has been observed at the Free Electron Laser in Hamburg, (FLASH). Recording coincident fragments C{sup +} + CH{sub 2}{sup +} as a function of time between XUV-pump and -probe pulses, generated by a split-mirror device, we find an isomerization time of 52 {+-} 15 fs in a kinetic energy release (KER) window of 5.8 < KER < 8 eV, providing clear evidence for the existence of a fast, nonradiative decay channel.

  1. Frequency-resolved optical gating technique for retrieving the amplitude of a vibrational wavepacket

    NASA Astrophysics Data System (ADS)

    Nabekawa, Yasuo; Furukawa, Yusuke; Okino, Tomoya; Amani Eilanlou, A.; Takahashi, Eiji J.; Yamanouchi, Kaoru; Midorikawa, Katsumi

    2015-06-01

    We propose a novel method to determine the complex amplitude of each eigenfunction composing a vibrational wavepacket of / molecular ions evolving with a ~10 fs time scale. We find that the two-dimensional spectrogram of the kinetic energy release (KER) of H+/D+ fragments plotted against the time delay of the probe pulse is equivalent to the spectrogram used in the frequency-resolved optical gating (FROG) technique to retrieve the complex amplitude of an ultrashort optical pulse. By adapting the FROG algorithm to the delay-KER spectrogram of the vibrational wavepacket, we have successfully reconstructed the complex amplitude. The deterioration in retrieval accuracy caused by the bandpass filter required to process actual experimental data is also discussed.

  2. Ultrafast Extreme Ultraviolet Induced Isomerization of Acetylene Cations

    SciTech Connect

    Jiang, Y. H.; Kurka, M.; Kuehnel, K. U.; Schroeter, C. D.; Moshammer, R.; Rudenko, A.; Foucar, L.; Herrwerth, O.; Lezius, M.; Kling, M. F.; Tilborg, J. van; Belkacem, A.; Ueda, K.; Duesterer, S.; Treusch, R.; Ullrich, J.

    2010-12-31

    Ultrafast isomerization of acetylene cations ([HC=CH]{sup +}) in the low-lying excited A{sup 2}{Sigma}{sub g}{sup +} state, populated by the absorption of extreme ultraviolet (XUV) photons (38 eV), has been observed at the Free Electron Laser in Hamburg, (FLASH). Recording coincident fragments C{sup +}+CH{sub 2}{sup +} as a function of time between XUV-pump and -probe pulses, generated by a split-mirror device, we find an isomerization time of 52{+-}15 fs in a kinetic energy release (KER) window of 5.8<KER<8 eV, providing clear evidence for the existence of a fast, nonradiative decay channel.

  3. Phenylpropanoid derivatives from edible canna, Canna edulis.

    PubMed

    Yun, Young Sook; Satake, Motoyoshi; Katsuki, Shigeki; Kunugi, Akira

    2004-07-01

    Two phenylpropanoid sucrose esters were isolated from dry rhizomes of Canna edulis Ker Gawl., along with a known phenylpropanoid sucrose ester and four known phenylpropanoids. On the basis of analysis of spectroscopic data and chemical evidence, these two phenylpropanoid sucrose esters were shown to be 3-O-p-coumaroyl-6-O-feruloyl-beta-D-fructofuranosyl 6-O-acetyl-alpha-D-glucopyranoside and 3,6-di-O-p-coumaroyl-beta-D-fructofuranosyl 6-O-acetyl-alpha-D-glucopyranoside.

  4. Liquid-crystalline hybrid materials based on [60]fullerene and bent-core structures.

    PubMed

    Vergara, Jorge; Barberá, Joaquín; Serrano, José Luis; Ros, M Blanca; Sebastián, Nerea; de la Fuente, Rosario; López, David O; Fernández, Gustavo; Sánchez, Luis; Martín, Nazario

    2011-12-23

    What a core-ker! By the appropriate combination of promesogenic bent-core structures and the C(60)  unit, lamellar polar liquid-crystal phases were induced. The supramolecular organization of the functional fullerene-based assemblies, the temperature range of the soft phase, the stabilization of the mesophase-like order at room temperature, and the molecular switching under an electric field can be tuned, depending on the molecular structure.

  5. Double-ionization mechanisms of the argon dimer in intense laser fields

    SciTech Connect

    Ulrich, B.; Vredenborg, A.; Malakzadeh, A.; Meckel, M.; Cole, K.; Jahnke, T.; Doerner, R.; Smolarski, M.; Chang, Z.

    2010-07-15

    We have measured the two-site double ionization of argon dimers by ultrashort laser pulses leading to fragmentation into two singly charged argon ions. Contrary to the expectations from a pure Coulomb explosion following rapid removal of one electron from each of the atoms, we find three distinct peaks in the kinetic energy release (KER) distribution. By measuring the angular distribution of the fragment ions and the vector momentum of one of the emitted electrons for circular and linear laser polarization, we are able to unravel the ionization mechanisms leading to the three features in the KER. The most abundant one results from tunnel ionization at one site followed by charge-enhanced tunnel ionization of the second atom. The second mechanism, which leads to a higher KER we identify as sequential tunnel ionization of both atoms accompanied by excitation. The third mechanism is present with linearly polarized light only. It is most likely a frustrated triple ionization, where the third electron does not escape but is trapped in a Rydberg state.

  6. Metastable anions of dinitrobenzene: Resonances for electron attachment and kinetic energy release

    SciTech Connect

    Mauracher, A.; Denifl, S.; Edtbauer, A.; Hager, M.; Probst, M.; Scheier, P.; Echt, O.; Maerk, T. D.; Field, T. A.; Graupner, K.

    2010-12-28

    Attachment of free, low-energy electrons to dinitrobenzene (DNB) in the gas phase leads to DNB{sup -} as well as several fragment anions. DNB{sup -}, (DNB-H){sup -}, (DNB-NO){sup -}, (DNB-2NO){sup -}, and (DNB-NO{sub 2}){sup -} are found to undergo metastable (unimolecular) dissociation. A rich pattern of resonances in the yield of these metastable reactions versus electron energy is observed; some resonances are highly isomer-specific. Most metastable reactions are accompanied by large average kinetic energy releases (KER) that range from 0.5 to 1.32 eV, typical of complex rearrangement reactions, but (1,3-DNB-H){sup -} features a resonance with a KER of only 0.06 eV for loss of NO. (1,3-DNB-NO){sup -} offers a rare example of a sequential metastable reaction, namely, loss of NO followed by loss of CO to yield C{sub 5}H{sub 4}O{sup -} with a large KER of 1.32 eV. The G4(MP2) method is applied to compute adiabatic electron affinities and reaction energies for several of the observed metastable channels.

  7. Construction of a Rapid Feather-Degrading Bacterium by Overexpression of a Highly Efficient Alkaline Keratinase in Its Parent Strain Bacillus amyloliquefaciens K11.

    PubMed

    Yang, Lian; Wang, Hui; Lv, Yi; Bai, Yingguo; Luo, Huiying; Shi, Pengjun; Huang, Huoqing; Yao, Bin

    2016-01-13

    Keratinase is essential to degrade the main feather component, keratin, and is of importance for wide industrial applications. In this study, Bacillus amyloliquefaciens strain K11 was found to have significant feather-degrading capacity (completely degraded whole feathers within 24 h). The keratinase encoding gene, kerK, was expressed in Bacillus subtilis SCK6. The purified recombinant KerK showed optimal activity at 50 °C and pH 11.0 and degraded whole feathers within 0.5 h in the presence of DTT. The recombinant plasmids harboring kerK were extracted from B. subtilis SCK6 and transformed into B. amyloliquefaciens K11. As a result, the recombinant B. amyloliquefaciens K11 exhibited enhanced feather-degrading capacity with shortened reaction time within 12 h and increased keratinolytic activity (1500 U/mL) by 6-fold. This efficient and rapid feather-degrading character makes the recombinant strain of B. amyloliquefaciens K11 have potential for applications in feather meal preparation and waste feather disposal.

  8. Imaging the radical channel in acetaldehyde photodissociation: Competing mechanisms at energies close to the triplet exit barrier

    SciTech Connect

    Amaral, G. A.; Arregui, A.; Rodriguez, J. D.; Banares, L.; Rubio-Lago, L.

    2010-08-14

    The photodissociation of acetaldehyde in the radical channel has been studied at wavelengths between 315 and 325 nm using the velocity-map imaging technique. Upon one-photon absorption at 315 nm, the molecule is excited to the first singlet excited state S{sub 1}, which, in turn, undergoes intersystem crossing to the first excited triplet state T{sub 1}. On the triplet surface, the molecule dissociates into CH{sub 3} and HCO radicals with large kinetic energy release (KER), in accordance with the well characterized exit barrier on T{sub 1}. However, at longer wavelengths (>320 nm), which correspond to excitation energies just below the triplet barrier, a sudden change in KER is observed. At these photolysis wavelengths, there is not enough energy to surpass the exit barrier on the triplet state, which leaves the possibility of unimolecular dissociation on S{sub 0} after internal conversion from S{sub 1}. We have characterized the fragments' KER at these wavelengths, as well as determined the energy partitioning for the radical fragments. A new accurate estimate of the barrier height on T{sub 1} is presented.

  9. Auger decay of 1{sigma}{sub g} and 1{sigma}{sub u} hole states of the N{sub 2} molecule. II. Young-type interference of Auger electrons and its dependence on internuclear distance

    SciTech Connect

    Cherepkov, N. A.; Semenov, S. K.; Schoeffler, M. S.; Titze, J.; Petridis, N.; Jahnke, T.; Cole, K.; Schmidt, L. Ph. H.; Czasch, A.; Jagutzki, O.; Schmidt-Boecking, H.; Doerner, R.; Akoury, D.; Williams, J. B.; Landers, A. L.; Osipov, T.; Lee, S.; Prior, M. H.; Belkacem, A.; Weber, Th.

    2010-08-15

    Theoretical two-center interference patterns produced (i) by the K-shell photoionization process of the N{sub 2} molecule and (ii) by the Auger decay process of the K-shell hole state of the N{sub 2} molecule are compared for the case of equal photo- and Auger-electron energies of about 360 eV. The comparison shows that both the angular distribution of the photoelectrons and the angular distribution of the Auger electrons of equal energy in the molecular frame are primarily defined by the Young interference. The experimental data for the angular resolved K-shell Auger electrons as a function of the kinetic-energy release (KER) obtained earlier [Phys. Rev. A 81, 043426 (2010)] have been renormalized in order to visualize the angular variation in the regions of low Auger-electron intensities. That renormalized data are compared with the corresponding theoretical results. From the known behavior of the potential energy curves, the connection between the KER and the internuclear distance can be established. Since the Young interference pattern is sensitive to the internuclear distance in the molecule, from the measured KER dependence of the Young interference pattern one can trace the behavior of the Auger-electron angular distribution for different molecular terms as a function of internuclear distance. The results of that analysis are in a good agreement with the corresponding theoretical predictions.

  10. Structural inheritance and selective reactivation in the central Andes: Cenozoic deformation guided by pre-Andean structures in southern Peru

    NASA Astrophysics Data System (ADS)

    Perez, Nicholas D.; Horton, Brian K.; Carlotto, Victor

    2016-03-01

    Structural, stratigraphic, and geochronologic constraints from the Eastern Cordillera in the central Andean plateau of southern Peru (14-15°S) demonstrate the existence and position of major pre-Andean structures that controlled the accumulation of Triassic synrift fill and guided subsequent Cenozoic deformation. The timing of initial clastic deposition of the Triassic Mitu Group is here constrained to ~ 242-233 Ma on the basis of detrital and volcanic zircon U-Pb geochronology. Regionally distinct provenance variations, as provided by U-Pb age populations from localized synrift accumulations, demonstrate Triassic erosion of multiple diagnostic sources from diverse rift-flank uplifts. Stratigraphic correlations suggest synchronous initiation of extensional basins containing the Mitu Group, in contrast with previous interpretations of southward rift propagation. Triassic motion along the NE-dipping San Anton normal fault accommodated up to 7 km of throw and hanging-wall deposition of a synrift Mitu succession > 2.5 km thick. The contrasting orientation of a non-reactivated Triassic normal fault suggests selective inversion of individual structures in the Eastern Cordillera was dependent on fault dip and strike. Selective preservation of a ~ 4 km thick succession of Carboniferous-Permian strata in the down-dropped San Anton hanging wall, beneath the synrift Mitu Group, suggests large-scale erosional removal in the uplifted footwall. Field and map observations identify additional pre-Andean thrust faults and folds attributed to poorly understood Paleozoic orogenic events preserved in the San Anton hanging wall. Selective thrust reactivation of normal and reverse faults during later compression largely guided Cenozoic deformation in the Eastern Cordillera. The resulting structural compartmentalization and across-strike variations in kinematics and deformation style highlight the influence of inherited Paleozoic structures and Triassic normal faults on the long

  11. Pigment characterization of important golden age panel paintings of the 17th century

    NASA Astrophysics Data System (ADS)

    Pięta, Ewa; Proniewicz, Edyta; Szmelter-Fausek, Bożena; Olszewska-Świetlik, Justyna; Proniewicz, Leonard M.

    2015-02-01

    Samples were obtained from two world-famous 17th century panel paintings of the Gdańsk school of panting: 'Seven Acts of Charity' (1607, in St. Mary's Church in Gdańsk, Poland) by Anton Möller and 'Angelic Concert' (1611, in Diocesan Museum in Pelplin, Poland) by Hermann Han. Micro-Raman spectroscopy (MRS), optical microscopy (OM), and X-ray fluorescence (XRF) spectroscopy studies of the samples were performed to characterize the pigments present in the individual painting layers (a rich palette of white, black, blue, red, and yellow pigments) and the pictorial techniques used by the artists.

  12. Pigment characterization of important golden age panel paintings of the 17th century.

    PubMed

    Pięta, Ewa; Proniewicz, Edyta; Szmelter-Fausek, Bożena; Olszewska-Świetlik, Justyna; Proniewicz, Leonard M

    2015-02-01

    Samples were obtained from two world-famous 17th century panel paintings of the Gdańsk school of panting: 'Seven Acts of Charity' (1607, in St. Mary's Church in Gdańsk, Poland) by Anton Möller and 'Angelic Concert' (1611, in Diocesan Museum in Pelplin, Poland) by Hermann Han. Micro-Raman spectroscopy (MRS), optical microscopy (OM), and X-ray fluorescence (XRF) spectroscopy studies of the samples were performed to characterize the pigments present in the individual painting layers (a rich palette of white, black, blue, red, and yellow pigments) and the pictorial techniques used by the artists.

  13. Darwin: German mystic or French rationalist?

    PubMed

    Ghiselin, Michael T

    2015-01-01

    The notion that Charles Darwin embraced the German Romantic tradition seems plausible, given the early influence of Alexander von Humboldt. But this view fails to do justice to other scientific traditions. Darwin was a protégé of the Englishman John Stevens Henslow and was a follower of the Scott Charles Lyell. He had important debts to French scientists, notably Henri Milne-Edwards, Etienne and Isidore Geoffroy Saint-Hilaire, and Alphonse de Candolle. Many Germans were quite supportive of Darwin, but not all of these were encumbered by idealistic metaphysical baggage. Both Darwin and Anton Dohrn treated science as very much a cosmopolitan enterprise.

  14. Early modern experimentation on live animals.

    PubMed

    Bertoloni Meli, Domenico

    2013-01-01

    Starting from the works by Aselli (De lactibus sive lacteis venis, 1627) on the milky veins and Harvey (1628, translated in 1993) on the motion of the heart and the circulation of the blood, the practice of vivisection witnessed a resurgence in the early modern period. I discuss some of the most notable cases in the century spanning from Aselli's work to the investigations of fluid pressure in plants and animals by Stephen Hales (Vegetable Staticks, 1727). Key figures in my study include Johannes Walaeus, Jean Pecquet, Marcello Malpighi, Reinier de Graaf, Richard Lower, Anton Nuck, and Anton de Heide. Although vivisection dates from antiquity, early modern experimenters expanded the range of practices and epistemic motivations associated with it, displaying considerable technical skills and methodological awareness about the problems associated with the animals being alive and the issue of generalizing results to humans. Many practitioners expressed great discomfort at the suffering of the animals; however, many remained convinced that their investigations were not only indispensable from an epistemic standpoint but also had potential medical applications. Early modern vivisection experiments were both extensive and sophisticated and cannot be ignored in the literature of early modern experimentation or of experimentation on living organisms across time.

  15. Embryos in evolution: evo-devo at the Naples Zoological Station in 1874.

    PubMed

    Hall, Brian K

    2009-03-01

    Eighteen seventy-four was a high point in evolutionary embryology. Thanks to Charles Darwin, the theory of evolution by natural selection provided a revolutionary new way of viewing the relationships and origins of organisms on Earth. Thanks to Ernst Haeckel, embryos were the way to study evolution (Haeckel in Generelle morphologie der organismen, vols 1, 2. Verlag Georg Reimer, Berlin, 1866)-it really was embryos in evolution-and recapitulation was in the air. Thanks to Anton Dohrn, a new research facility was on the ground, designed, located and structured to facilitate the study of embryos in evolution. Anton Dohrn devised, designed, financed, supervised the construction and then administered the Naples Zoological Station specifically so that researchers from all nations would have a facility where Darwin's theory of evolution by natural selection could be tested. The zoologists who took advantage of the brand new facility within weeks of its opening late in 1873 established lines of research into evolutionary embryology, the field we now know as evolutionary developmental biology (evo-devo), the study of embryos in evolution. I examine the approach taken by Ambrosius Hubrecht, the first Dutch embryologist to undertake research at the station, and then evaluate the research of three British zoologists-E. Ray Lankester, Albert Dew-Smith, and Francis Maitland (Frank) Balfour. All four sought insights into origins, especially vertebrate origins that rested on comparative embryology, homology, germ layers, and a Darwinian approach to origins. PMID:19214616

  16. Heredity, evolution and development in their (epistemic) environment at the turn of the nineteenth century.

    PubMed

    Colonna, Federica Turriziani

    2016-03-01

    During the early 1870s a young zoologist who worked as a Privatdozent delivering lectures at different Prussian universities invested much of his family wealth and solicited his fellows' contributions to establish a research facility by the sea. The young zoologist happened to be called Anton Dohrn. From the time it opened its doors, the Anton Dohrn Zoological Station - or Naples Zoological Station, as it was originally called - played a crucial role in shaping life sciences as it facilitated research aimed at explaining the mechanics of inheritance. During the last quarter of the nineteenth century and the first decades of the twentieth, zoologists attempted to explain how evolutionary changes occur within a population and become stabilized. In so doing, they looked at developmental processes as well as environmental pressure, coming up with different hypotheses to explain inheritance. In some cases, their research was highly speculative, whereas in other cases they conducted cytological observations to identify the material basis of heredity. Research on evolution and development has been carried out in different places, and zoological stations like the one in Naples have played a major role in this story. However, numerous biological institutions active at the turn of the twentieth century have not received much attention from historians.

  17. Early modern experimentation on live animals.

    PubMed

    Bertoloni Meli, Domenico

    2013-01-01

    Starting from the works by Aselli (De lactibus sive lacteis venis, 1627) on the milky veins and Harvey (1628, translated in 1993) on the motion of the heart and the circulation of the blood, the practice of vivisection witnessed a resurgence in the early modern period. I discuss some of the most notable cases in the century spanning from Aselli's work to the investigations of fluid pressure in plants and animals by Stephen Hales (Vegetable Staticks, 1727). Key figures in my study include Johannes Walaeus, Jean Pecquet, Marcello Malpighi, Reinier de Graaf, Richard Lower, Anton Nuck, and Anton de Heide. Although vivisection dates from antiquity, early modern experimenters expanded the range of practices and epistemic motivations associated with it, displaying considerable technical skills and methodological awareness about the problems associated with the animals being alive and the issue of generalizing results to humans. Many practitioners expressed great discomfort at the suffering of the animals; however, many remained convinced that their investigations were not only indispensable from an epistemic standpoint but also had potential medical applications. Early modern vivisection experiments were both extensive and sophisticated and cannot be ignored in the literature of early modern experimentation or of experimentation on living organisms across time. PMID:22684270

  18. Embryos in evolution: evo-devo at the Naples Zoological Station in 1874.

    PubMed

    Hall, Brian K

    2009-03-01

    Eighteen seventy-four was a high point in evolutionary embryology. Thanks to Charles Darwin, the theory of evolution by natural selection provided a revolutionary new way of viewing the relationships and origins of organisms on Earth. Thanks to Ernst Haeckel, embryos were the way to study evolution (Haeckel in Generelle morphologie der organismen, vols 1, 2. Verlag Georg Reimer, Berlin, 1866)-it really was embryos in evolution-and recapitulation was in the air. Thanks to Anton Dohrn, a new research facility was on the ground, designed, located and structured to facilitate the study of embryos in evolution. Anton Dohrn devised, designed, financed, supervised the construction and then administered the Naples Zoological Station specifically so that researchers from all nations would have a facility where Darwin's theory of evolution by natural selection could be tested. The zoologists who took advantage of the brand new facility within weeks of its opening late in 1873 established lines of research into evolutionary embryology, the field we now know as evolutionary developmental biology (evo-devo), the study of embryos in evolution. I examine the approach taken by Ambrosius Hubrecht, the first Dutch embryologist to undertake research at the station, and then evaluate the research of three British zoologists-E. Ray Lankester, Albert Dew-Smith, and Francis Maitland (Frank) Balfour. All four sought insights into origins, especially vertebrate origins that rested on comparative embryology, homology, germ layers, and a Darwinian approach to origins.

  19. Fragmentation of multiply charged hydrocarbon molecules C{sub n}H{sup q+} (n{<=} 4, q{<=} 9) produced in high-velocity collisions: Branching ratios and kinetic energy release of the H{sup +} fragment

    SciTech Connect

    Beroff, K.; Pino, T.; Carpentier, Y.; Van-Oanh, N. T.; Chabot, M.; Tuna, T.; Martinet, G.; Le Padellec, A.; Lavergne, L.

    2011-09-15

    Fragmentation branching ratios for channels involving H{sup +} emission and associated kinetic energy release of the H{sup +} fragment [KER(H{sup +})] have been measured for multicharged C{sub n}H{sup q+} molecules produced in high velocity (3.6 a.u.) collisions between C{sub n}H{sup +} projectiles and helium atoms. For CH{sup q+} (q{<=} 4) molecules, measured KER(H{sup +}) were found well below predictions of the simple point charge Coulomb model (PCCM) for all q values. Multireference configuration interaction (MRCI) calculations for ground as well as electronic excited states were performed which allowed a perfect interpretation of the CH{sup q+} experimental results for low charges (q = 2-3) as well as for the highest charge (q = 4). In this last case we could show, on the basis of ionization cross sections calculations and experimental measurements performed on the same systems at slightly higher velocity (4.5 a.u.), the prominent role played by inner-shell ionization followed by Auger relaxation and could extract the lifetime of this Auger relaxation giving rise to the best agreement between the experiment and the calculations. For dissociation of C{sub 2}H{sup q+} and C{sub 3}H{sup q+} with the highest charges (q{>=} 5), inner-shell ionization contributed in a prominent way to the ion production. In these two cases it was shown that measured KER(H{sup +}) were in good agreement with PCCM predictions when those were corrected for Auger relaxation with the same Auger lifetime value as in CH{sup 3+}.

  20. Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

    PubMed Central

    Villeneuve, Daniel L.; Crump, Doug; Garcia-Reyero, Natàlia; Hecker, Markus; Hutchinson, Thomas H.; LaLone, Carlie A.; Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Ottinger, Mary Ann; Vergauwen, Lucia; Whelan, Maurice

    2014-01-01

    An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of a biological system and an adverse outcome at a level of biological organization of regulatory relevance. Systematic organization of information into AOP frameworks has potential to improve regulatory decision-making through greater integration and more meaningful use of mechanistic data. However, for the scientific community to collectively develop a useful AOP knowledgebase that encompasses toxicological contexts of concern to human health and ecological risk assessment, it is critical that AOPs be developed in accordance with a consistent set of core principles. Based on the experiences and scientific discourse among a group of AOP practitioners, we propose a set of five fundamental principles that guide AOP development: (1) AOPs are not chemical specific; (2) AOPs are modular and composed of reusable components—notably key events (KEs) and key event relationships (KERs); (3) an individual AOP, composed of a single sequence of KEs and KERs, is a pragmatic unit of AOP development and evaluation; (4) networks composed of multiple AOPs that share common KEs and KERs are likely to be the functional unit of prediction for most real-world scenarios; and (5) AOPs are living documents that will evolve over time as new knowledge is generated. The goal of the present article was to introduce some strategies for AOP development and detail the rationale behind these 5 key principles. Consideration of these principles addresses many of the current uncertainties regarding the AOP framework and its application and is intended to foster greater consistency in AOP development. PMID:25466378

  1. Distribution of Barley yellow dwarf virus-PAV in the Sub-Antarctic Kerguelen Islands and Characterization of Two New Luteovirus Species.

    PubMed

    Svanella-Dumas, Laurence; Candresse, Thierry; Hullé, Maurice; Marais, Armelle

    2013-01-01

    A systematic search for viral infection was performed in the isolated Kerguelen Islands, using a range of polyvalent genus-specific PCR assays. Barley yellow dwarf virus (BYDV) was detected in both introduced and native grasses such as Poa cookii. The geographical distribution of BYDV and its prevalence in P. cookii were analyzed using samples collected from various sites of the archipelago. We estimate the average prevalence of BYDV to be 24.9% in P. cookii, with significant variability between sites. BYDV genetic diversity was assessed using sequence information from two genomic regions: the P3 open reading frame (ORF) (encoding the coat protein) and the hypervariable P6 ORF region. The phylogenetic analysis in the P3 region showed that BYDV sequences segregate into three major lineages, the most frequent of which (Ker-I cluster) showed close homology with BYDV-PAV-I isolates and had very low intra-lineage diversity (0.6%). A similarly low diversity was also recorded in the hypervariable P6 region, suggesting that Ker-I isolates derive from the recent introduction of BYDV-PAV-I. Divergence time estimation suggests that BYDV-PAV-I was likely introduced in the Kerguelen environment at the same time frame as its aphid vector, Rhopalosiphum padi, whose distribution shows good overlap with that of BYDV-Ker-I. The two other lineages show more than 22% amino acid divergence in the P3 region with other known species in the BYDV species complex, indicating that they represent distinct BYDV species. Using species-specific amplification primers, the distribution of these novel species was analyzed. The high prevalence of BYDV on native Poaceae and the presence of the vector R. padi, raises the question of its impact on the vulnerable plant communities of this remote ecosystem. PMID:23825645

  2. Distribution of Barley yellow dwarf virus-PAV in the Sub-Antarctic Kerguelen Islands and Characterization of Two New Luteovirus Species

    PubMed Central

    Svanella-Dumas, Laurence; Candresse, Thierry; Hullé, Maurice; Marais, Armelle

    2013-01-01

    A systematic search for viral infection was performed in the isolated Kerguelen Islands, using a range of polyvalent genus-specific PCR assays. Barley yellow dwarf virus (BYDV) was detected in both introduced and native grasses such as Poa cookii. The geographical distribution of BYDV and its prevalence in P. cookii were analyzed using samples collected from various sites of the archipelago. We estimate the average prevalence of BYDV to be 24.9% in P. cookii, with significant variability between sites. BYDV genetic diversity was assessed using sequence information from two genomic regions: the P3 open reading frame (ORF) (encoding the coat protein) and the hypervariable P6 ORF region. The phylogenetic analysis in the P3 region showed that BYDV sequences segregate into three major lineages, the most frequent of which (Ker-I cluster) showed close homology with BYDV-PAV-I isolates and had very low intra-lineage diversity (0.6%). A similarly low diversity was also recorded in the hypervariable P6 region, suggesting that Ker-I isolates derive from the recent introduction of BYDV-PAV-I. Divergence time estimation suggests that BYDV-PAV-I was likely introduced in the Kerguelen environment at the same time frame as its aphid vector, Rhopalosiphum padi, whose distribution shows good overlap with that of BYDV-Ker-I. The two other lineages show more than 22% amino acid divergence in the P3 region with other known species in the BYDV species complex, indicating that they represent distinct BYDV species. Using species-specific amplification primers, the distribution of these novel species was analyzed. The high prevalence of BYDV on native Poaceae and the presence of the vector R. padi, raises the question of its impact on the vulnerable plant communities of this remote ecosystem. PMID:23825645

  3. Adverse outcome pathway (AOP) development I: strategies and principles.

    PubMed

    Villeneuve, Daniel L; Crump, Doug; Garcia-Reyero, Natàlia; Hecker, Markus; Hutchinson, Thomas H; LaLone, Carlie A; Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Ottinger, Mary Ann; Vergauwen, Lucia; Whelan, Maurice

    2014-12-01

    An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of a biological system and an adverse outcome at a level of biological organization of regulatory relevance. Systematic organization of information into AOP frameworks has potential to improve regulatory decision-making through greater integration and more meaningful use of mechanistic data. However, for the scientific community to collectively develop a useful AOP knowledgebase that encompasses toxicological contexts of concern to human health and ecological risk assessment, it is critical that AOPs be developed in accordance with a consistent set of core principles. Based on the experiences and scientific discourse among a group of AOP practitioners, we propose a set of five fundamental principles that guide AOP development: (1) AOPs are not chemical specific; (2) AOPs are modular and composed of reusable components-notably key events (KEs) and key event relationships (KERs); (3) an individual AOP, composed of a single sequence of KEs and KERs, is a pragmatic unit of AOP development and evaluation; (4) networks composed of multiple AOPs that share common KEs and KERs are likely to be the functional unit of prediction for most real-world scenarios; and (5) AOPs are living documents that will evolve over time as new knowledge is generated. The goal of the present article was to introduce some strategies for AOP development and detail the rationale behind these 5 key principles. Consideration of these principles addresses many of the current uncertainties regarding the AOP framework and its application and is intended to foster greater consistency in AOP development. PMID:25466378

  4. Formation of inner-shell autoionizing CO+ states below the CO++ threshold

    SciTech Connect

    Osipov, Timur; Weber, Thorsten; Rescigno, Thomas N; Lee, Sun; Orel, Ann; Schoffler, Markus; Sturm, Felix; Schossler, S.; Lenz, U.; Havermeier, T.; Kuhnel, M.; Jahnke, Till; Williams, J. B.; Ray, D.; Landers, Alan; Dorner, Reinhard; Belkacem, Ali

    2009-12-27

    We report a kinematically complete experiment on the production of CO{sup +} autoionizing states following photoionization of carbon monoxide below its vertical double ionization threshold. Momentum imaging spectroscopy is used to measure the energies and body-frame angular distributions of both photo- and autoionization electrons, as well as the kinetic energy release (KER) of the atomic ions. This data, in combination with ab initio theoretical calculations, provides insight into the nature of the cation states produced and their subsequent dissociation into autoionizing atomic (O*) fragments.

  5. An interdecadal change in the relationship between the western North Pacific Ocean and the East Asian summer monsoon

    NASA Astrophysics Data System (ADS)

    Yu, Peilong; Zhang, Lifeng; Zhong, Quanjia

    2016-09-01

    This study reveals that the relationship between the western North Pacific Ocean (WNPO; 0-55°N, 100-165°E) and the East Asian summer monsoon (EASM) experiences a well-defined interdecadal change in the late 1980s and early 1990s. The EASM-related WNPO sea surface temperature anomaly (SSTA) pattern changes from the dipole pattern [WNPO dipole (WNPOD)] that develops over the period between 1968 and 1987 (P1) to a tripole pattern [WNPO tripole (WNPOT)] between 1991 and 2010 (P2). The positive (negative) phase of the WNPOD is characterized by warm (cold) SSTAs in the Japan Sea and Kuroshio-Oyashio Extension region, and cold (warm) SSTAs in the subtropical WNPO, whereas the positive (negative) phase of the WNPOT shows warming (cooling) in the Kuroshio Extension region (KER), and cooling (warming) in the south of Kamchatka Peninsula (SKP) and Philippine Sea (PS). During P1 (P2), the WNPOD (WNPOT) can be regarded as the first (second) leading mode of summer WNPO SST variability, and its positive phase is associated with a weakened WNPO subtropical high and thereby the deficient summer rainfall in the Yangtze River valley, together with a strong EASM, and vice versa. The change in the WNPO-EASM relationship may be caused by interdecadal changes in the relationship of the equatorial central Pacific (ECP) with the WNPO and EASM, and an increase in summer KER SST variability. During P2, because the ECP warming-induced cyclonic anomalies move northwestwards and intensify, summertime ECP warming is able to generate a strong EASM and significant cooling over the two poles of the WNPOT (SKP and PS). These strengthened impacts of the ECP on the WNPOT and EASM contribute to the strengthened WNPOT-EASM relationship during P2. In addition, summer KER SST variability increases between 1991 and 2010, and this may have enhanced the impact of the KER on the EASM during P2. These two factors probably cause the EASM-related WNPO SSTA pattern to change from the WNPOD in P1 to the WNPOT in

  6. Phenylpropanoid derivatives from edible canna, Canna edulis.

    PubMed

    Yun, Young Sook; Satake, Motoyoshi; Katsuki, Shigeki; Kunugi, Akira

    2004-07-01

    Two phenylpropanoid sucrose esters were isolated from dry rhizomes of Canna edulis Ker Gawl., along with a known phenylpropanoid sucrose ester and four known phenylpropanoids. On the basis of analysis of spectroscopic data and chemical evidence, these two phenylpropanoid sucrose esters were shown to be 3-O-p-coumaroyl-6-O-feruloyl-beta-D-fructofuranosyl 6-O-acetyl-alpha-D-glucopyranoside and 3,6-di-O-p-coumaroyl-beta-D-fructofuranosyl 6-O-acetyl-alpha-D-glucopyranoside. PMID:15279991

  7. Observation of two sequential pathways of (CO2 ) 3 + dissociation by heavy-ion impact

    NASA Astrophysics Data System (ADS)

    Yan, S.; Zhu, X. L.; Zhang, P.; Ma, X.; Feng, W. T.; Gao, Y.; Xu, S.; Zhao, Q. S.; Zhang, S. F.; Guo, D. L.; Zhao, D. M.; Zhang, R. T.; Huang, Z. K.; Wang, H. B.; Zhang, X. J.

    2016-09-01

    An experimental investigation of the breakup of (CO2 ) 3 + induced by N e4 + ion impact at incident energies of 1.12 MeV was performed. By analyzing the momentum distributions and the kinetic energies of the three fragment ions, the nonsequential and sequential dissociation mechanisms are verified. In contrast to highly charged ion impact, two different sequential decay pathways were observed in the present experiment. One pathway originates from the primary cation (CO2 ) 3 + populated into +4Σ states by collision charge exchange and its daughter cation (CO) 2 + populated into the two excited states (3Π and X 1Π ) by the first fragmentation step, resulting in a lower KER peak. The other pathway originates from the primary cation (CO2 ) 3 + locating at 6Π state, and its daughter cation (CO) 2 + populated into the metastable excited states 3Π , X 1Π , and +3Σ, leading to the higher KER peak. Our work is a breakup experiment of (CO2 ) 3 + presenting the initial states of the parent cation (CO2 ) 3 + and the metastable states of C O2 + ion simultaneously.

  8. Identification of two new keratinolytic proteases from a Bacillus pumilus strain using protein analysis and gene sequencing.

    PubMed

    Fellahi, Soltana; Chibani, Abdelwaheb; Feuk-Lagerstedt, Elisabeth; Taherzadeh, Mohammad J

    2016-12-01

    The Bacillus strain (CCUG 66887) has a high capacity to excrete keratinase with the ability to degrade both alpha- and beta keratin. In this study we aimed to show the characteristics of the keratinolytic protease and to identify its gene by using liquid chromatography-electrospray ionization tandem mass spectrometry methods (nanoHPLC-ESI-MS/MS) followed by Mascot data base search. The results showed that the enzyme in fact consists of two different keratinases, both with a molecular mass of 38 kDa. Further, DNA sequencing generated the open reading frame (ORF) of one of the genes (Ker1), and de novo genome sequencing identified the ORF of the second gene (Ker2). The two keratinase genes contain 1153 base pairs each and have a gene similarity of 67 %. In addition, the Bacillus strain was classified as Bacillus pumilus and its genes were annotated in the GeneBank at NCBI (accession: CP011109.1). Amino acid sequences alignment with known B. pumilus proteases indicated that the two keratinases of B. pumilus strain C4 are subtilisin-like serine proteases belonging to the Protease S8 family. Taken together, these result suggest the two keratinases as promising candidates for enzymatic processing of keratinous wastes in waste refinery. PMID:27363997

  9. Adverse outcome pathway development II: best practices.

    PubMed

    Villeneuve, Daniel L; Crump, Doug; Garcia-Reyero, Natàlia; Hecker, Markus; Hutchinson, Thomas H; LaLone, Carlie A; Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Ottinger, Mary Ann; Vergauwen, Lucia; Whelan, Maurice

    2014-12-01

    Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized through development of internationally harmonized guidance and principles. The goal of this article was to outline the information content desired for formal AOP description and some rules of thumb and best practices intended to facilitate reuse and connectivity of elements of an AOP description in a knowledgebase and network context. For example, key events (KEs) are measurements of change in biological state that are indicative of progression of a perturbation toward a specified adverse outcome. Best practices for KE description suggest that each KE should be defined as an independent measurement made at a particular level of biological organization. The concept of "functional equivalence" can help guide both decisions about how many KEs to include in an AOP and the specificity with which they are defined. Likewise, in describing both KEs and evidence that supports a causal linkage or statistical association between them (ie, a key event relationship; KER), best practice is to build from and contribute to existing KE or KER descriptions in the AOP knowledgebase rather than creating redundant descriptions. The best practices proposed address many of the challenges and uncertainties related to AOP development and help promote a consistent and reliable, yet flexible approach. PMID:25466379

  10. Rydberg and valence state excitation dynamics: a velocity map imaging study involving the E-V state interaction in HBr.

    PubMed

    Zaouris, Dimitris; Kartakoullis, Andreas; Glodic, Pavle; Samartzis, Peter C; Rafn Hróðmarsson, Helgi; Kvaran, Ágúst

    2015-04-28

    Photoexcitation dynamics of the E((1)Σ(+)) (v' = 0) Rydberg state and the V((1)Σ(+)) (v') ion-pair vibrational states of HBr are investigated by velocity map imaging (VMI). H(+) photoions, produced through a number of vibrational and rotational levels of the two states were imaged and kinetic energy release (KER) and angular distributions were extracted from the data. In agreement with previous work, we found the photodissociation channels forming H*(n = 2) + Br((2)P3/2)/Br*((2)P1/2) to be dominant. Autoionization pathways leading to H(+) + Br((2)P3/2)/Br*((2)P1/2) via either HBr(+)((2)Π3/2) or HBr(+)*((2)Π1/2) formation were also present. The analysis of KER and angular distributions and comparison with rotationally and mass resolved resonance enhanced multiphoton ionization (REMPI) spectra revealed the excitation transition mechanisms and characteristics of states involved as well as the involvement of the E-V state interactions and their v' and J' dependence. PMID:25801122

  11. Adverse outcome pathway development II: best practices.

    PubMed

    Villeneuve, Daniel L; Crump, Doug; Garcia-Reyero, Natàlia; Hecker, Markus; Hutchinson, Thomas H; LaLone, Carlie A; Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Ottinger, Mary Ann; Vergauwen, Lucia; Whelan, Maurice

    2014-12-01

    Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized through development of internationally harmonized guidance and principles. The goal of this article was to outline the information content desired for formal AOP description and some rules of thumb and best practices intended to facilitate reuse and connectivity of elements of an AOP description in a knowledgebase and network context. For example, key events (KEs) are measurements of change in biological state that are indicative of progression of a perturbation toward a specified adverse outcome. Best practices for KE description suggest that each KE should be defined as an independent measurement made at a particular level of biological organization. The concept of "functional equivalence" can help guide both decisions about how many KEs to include in an AOP and the specificity with which they are defined. Likewise, in describing both KEs and evidence that supports a causal linkage or statistical association between them (ie, a key event relationship; KER), best practice is to build from and contribute to existing KE or KER descriptions in the AOP knowledgebase rather than creating redundant descriptions. The best practices proposed address many of the challenges and uncertainties related to AOP development and help promote a consistent and reliable, yet flexible approach.

  12. Adverse Outcome Pathway Development II: Best Practices

    PubMed Central

    Villeneuve, Daniel L.; Crump, Doug; Garcia-Reyero, Natàlia; Hecker, Markus; Hutchinson, Thomas H.; LaLone, Carlie A.; Landesmann, Brigitte; Lettieri, Teresa; Munn, Sharon; Nepelska, Malgorzata; Ottinger, Mary Ann; Vergauwen, Lucia; Whelan, Maurice

    2014-01-01

    Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized through development of internationally harmonized guidance and principles. The goal of this article was to outline the information content desired for formal AOP description and some rules of thumb and best practices intended to facilitate reuse and connectivity of elements of an AOP description in a knowledgebase and network context. For example, key events (KEs) are measurements of change in biological state that are indicative of progression of a perturbation toward a specified adverse outcome. Best practices for KE description suggest that each KE should be defined as an independent measurement made at a particular level of biological organization. The concept of “functional equivalence” can help guide both decisions about how many KEs to include in an AOP and the specificity with which they are defined. Likewise, in describing both KEs and evidence that supports a causal linkage or statistical association between them (ie, a key event relationship; KER), best practice is to build from and contribute to existing KE or KER descriptions in the AOP knowledgebase rather than creating redundant descriptions. The best practices proposed address many of the challenges and uncertainties related to AOP development and help promote a consistent and reliable, yet flexible approach. PMID:25466379

  13. Lie algebra on the transverse bundle of a decreasing family of foliations

    NASA Astrophysics Data System (ADS)

    Lebtahi, Leila

    2010-01-01

    J. Lehmann-Lejeune in [J. Lehmann-Lejeune, Cohomologies sur le fibré transverse à un feuilletage, C.R.A.S. Paris 295 (1982), 495-498] defined on the transverse bundle V to a foliation on a manifold M, a zero-deformable structure J such that J2=0 and for every pair of vector fields X, Y on M: [JX,JY]-J[JX,Y]-J[X,JY]+J2[X,Y]=0. For every open set Ω of V, J. Lehmann-Lejeune studied the Lie Algebra LJ(Ω) of vector fields X defined on Ω such that the Lie derivative L(X)J is equal to zero i.e., for each vector field Yon Ω: [X,JY]=J[X,Y] and showed that for every vector field X on Ω such that X∈KerJ, we can write X=∑[Y,Z] where ∑is a finite sum and Y,Z belongs to LJ(Ω)∩(KerJ). In this note, we study a generalization for a decreasing family of foliations.

  14. Momentum imaging spectrometer for molecular fragmentation dynamics induced by pulsed electron beam.

    PubMed

    Wang, EnLiang; Shan, Xu; Shi, YuFeng; Tang, YaGuo; Chen, XiangJun

    2013-12-01

    A momentum imaging spectrometer has been built for studying the electron impact molecular fragmentation dynamics. The setup consists of a pulsed electron gun and a time of flight system as well as a two-dimensional time and position sensitive multi-hit detector. The charged fragments with kinetic energy up to 10 eV can be detected in 4π solid angles and their three-dimensional momentum vectors can be reconstructed. The apparatus is tested by electron impact ionization of Ar and dissociative ionization of CO2. By analyzing the ion-ion coincidence spectra, the complete and incomplete Coulomb fragmentation channels for CO2(2+) and CO2(3+) are identified. The kinetic energy release (KER) and angular correlation for the two-body breakup channel CO2(2+*) → O(+) + CO(+) are reported. The peak value of total KER is found to be 6.8 eV which is consistent with the previous photoion-photoion coincidence studies, and the correlation angle of O(+) and CO(+) is also explicitly determined to be 172.5°. PMID:24387423

  15. The New Physics

    NASA Astrophysics Data System (ADS)

    Fraser, Gordon

    2009-08-01

    Introduction Gordon Fraser; Part I. Matter and the Universe: 1. Cosmology Wendy Freedman and Rocky Kolb; 2. Gravity Ronald Adler; 3. Astrophysics Arnon Dar; 4. Particles and the standard model Chris Quigg; 5. Superstrings Michael Green; Part II. Quantum Matter: 6. Atoms and photons Claude Cohen-Tannoudji and Jean Dalibard; 7. The quantum world of ultra-cold atoms Christopher Foot and William Phillips; 8. Superfluidity Henry Hall; 9. Quantum phase transitions Subir Sachdev; Part III. Quanta in Action: 10. Quantum entanglement Anton Zeilinger; 11. Quanta, ciphers and computers Artur Ekert; 12. Small-scale structure and nanoscience Yoseph Imry; Part IV. Calculation and Computation: 13. Nonlinearity Henry Abarbanel; 14. Complexity Antonio Politi; 15. Collaborative physics, e-science and the grid Tony Hey and Anne Trefethen; Part V. Science in Action: 16. Biophysics Cyrus Safinya; 17. Medical physics Nicolaj Pavel; 18. Physics and materials Robert Cahn; 19. Physics and society Ugo Amaldi.

  16. The New Physics

    NASA Astrophysics Data System (ADS)

    Fraser, Gordon

    2006-04-01

    Introduction Gordon Fraser; Part I. Matter and the Universe: 1. Cosmology Wendy Freedman and Rocky Kolb; 2. Gravity Ronald Adler; 3. Astrophysics Arnon Dar; 4. Particles and the standard model Chris Quigg; 5. Superstrings Michael Green; Part II. Quantum Matter: 6. Atoms and photons Claude Cohen-Tannoudji and Jean Dalibard; 7. The quantum world of ultra-cold atoms Christopher Foot and William Phillips; 8. Superfluidity Henry Hall; 9. Quantum phase transitions Subir Sachdev; Part III. Quanta in Action: 10. Quantum entanglement Anton Zeilinger; 11. Quanta, ciphers and computers Artur Ekert; 12. Small-scale structure and nanoscience Yoseph Imry; Part IV. Calculation and Computation: 13. Nonlinearity Henry Abarbanel; 14. Complexity Antonio Politi; 15. Collaborative physics, e-science and the grid Tony Hey and Anne Trefethen; Part V. Science in Action: 16. Biophysics Cyrus Safinya; 17. Medical physics Nicolaj Pavel; 18. Physics and materials Robert Cahn; 19. Physics and society Ugo Amaldi.

  17. Corporeal elements and principles in the learned German chymical tradition.

    PubMed

    Klein, Joel A

    2014-11-01

    This paper explores diverse conceptions of the physicality and tangibility of elements and principles in early modern chymistry. By tracing the development of natural philosophical and corpuscular ideas about material elements and principles among several physicans and chymists, including Thomas Erastus, Andreas Libavius, Daniel Sennert, and Anton Günther Billich, this article locates a learned tradition that developed predominantly in Germany, and which directly challenged a common understanding of matter held by major Paracelsians as well as authors from the French textbook tradition. Likewise, conceptions of incorporeal elements or principles are shown to have developed from the ideas of Paracelsus and Petrus Severinus, whereas authors in the learned tradition emphasised a particular interpretation of Aristotle. The article concludes by suggesting that chymical interpretations of material composition had an important influence throughout the seventeenth and eighteenth centuries, and that this provides further evidence that the so-called "compositional revolution" in chemistry was well underway prior to the eighteenth century. PMID:25509634

  18. Comparison of electrophoretic and meristic characters of 0-group eel larvae from the Sargasso Sea

    NASA Astrophysics Data System (ADS)

    Comparini, A.; Schoth, M.

    1982-09-01

    Marked differences between continental samples of American and European eels have been detected electrophoretically in allele frequencies at the MDH-2 locus. Starch gel electrophoresis carried out on board F. R. V. “Anton Dohrn” during the eel expedition to the Sargasso Sea in 1979 revealed a similar clear-cut genetic difference in a sample of 0-group Anguilla leptocephali, thus confirming the classical theory of Schmidt (1932). The MDH-2 genotypes provide an additional diagnostic character for the distinction between young A. anguilla and A. rostrata leptocephali. Species identification by biochemical genetic characters did not correspond with that by meristic characters (myomere numbers) in ca. 13 % of the specimens studied; this discrepancy mainly concerns leptocephali of the A. anguilla genotype. The results obtained are critically discussed.

  19. The Sargasso Sea Eel Expedition 1979

    NASA Astrophysics Data System (ADS)

    Tesch, F.-W.

    1982-09-01

    The background and aims of the Sargasso Sea Expedition for exploring the reproduction of the eel ( Anguilla spp.) in the North Atlantic are described. The ships used for the investigations in the Sargasso Sea and during transects across the North Atlantic were F. R. V. “Anton Dohrn” and R. V. “Friedrich Heincke”, provided by the Federal Republic of Germany. Their technical and scientific equipment and their staffs are described. The courses of the cruises are mapped and the geographical positions of the investigations as well as the different instruments employed are tabulated as a source of basic data for more specialized papers published in this issue or elsewhere. Reference is also given to relevant papers which have been published elsewhere. Important but unpublished preliminary results are mentioned. Suggestions for future research needs are made.

  20. The New Physics and Cosmology - Dialogues with the Dalai Lama

    NASA Astrophysics Data System (ADS)

    Zajonc, Arthur; Houshmand, Zara

    2004-03-01

    What happens when the Dalai Lama meets with leading physicists and a historian? This book is the carefully edited record of the fascinating discussions at a Mind and Life conference in which five leading physicists and a historian (David Finkelstein, George Greenstein, Piet Hut, Arthur Zajonc, Anton Zeilinger, and Tu Weiming) discussed with the Dalai Lama current thought in theoretical quantum physics, in the context of Buddhist philosophy. A contribution to the science-religion interface, and a useful explanation of our basic understanding of quantum reality, couched at a level that intelligent readers without a deep involvement in science can grasp. In the tradition of other popular books on resonances between modern quantum physics and Zen or Buddhist mystical traditions--notably The Dancing Wu Li Masters and The Tao of Physics , this book gives a clear and useful update of the genuine correspondences between these two rather disparate approaches to understanding the nature of reality.

  1. [The case of Maria Theresia Paradis (1759-1824). On the treatment of (hysterical?) amaurosis in a musician with music and suggestion].

    PubMed

    Evers, S

    1991-08-01

    The musician and composer Maria Theresia Paradis (1759-1824) blind since her earliest childhood was treated in 1777 by the physician Dr. Franz-Anton Mesmer (1734-1815). The treatment he used was the so-called "magnetic therapy". This was a suggestive psychotherapeutical method by which, as he thought, the amaurosis could be cured. The most essential agency of this "magnetic therapy" was music. However, the resistance of both his colleagues and the patient's family forced him to break off the therapy. Maria Theresia Paradis remained blind till the end of her life. The genesis of the amaurosis, the problem of a real therapeutical influence by Mesmer and, especially, the relationship between the music as a therapeutical medium and the musical personality of the patient are discussed in detail. The whole care cannot be cleared up definitively. There are many indications that Mesmer succeeded in improving temporarily a hysterical amaurosis of Maria Theresia Paradis. PMID:1960933

  2. The power of a musical instrument: Franklin, the Mozarts, Mesmer, and the glass armonica.

    PubMed

    Gallo, D A; Finger, S

    2000-11-01

    In 1761 Benjamin Franklin invented the armonica (often referred to as the glass harmonica), an instrument designed to simplify the playing of the musical glasses. The instrument immediately became popular and inspired compositions by Wolfgang Mozart, who had the opportunity to hear and play one at the house of Franz Anton Mesmer. Armonica music was used by Mesmer in his séances, because he felt it could promote healing by propagating a mystical fluid that he called animal magnetism through the body. After Mesmer's theories were debunked by a highly respected panel of scientists, the armonica fell out of vogue. Because Franklin was on the panel that examined the discredited mesmerism, he indirectly contributed to his own invention's demise. PMID:11855437

  3. A review of the Magnus effect in aeronautics

    NASA Astrophysics Data System (ADS)

    Seifert, Jost

    2012-11-01

    The Magnus effect is well-known for its influence on the flight path of a spinning ball. Besides ball games, the method of producing a lift force by spinning a body of revolution in cross-flow was not used in any kind of commercial application until the year 1924, when Anton Flettner invented and built the first rotor ship Buckau. This sailboat extracted its propulsive force from the airflow around two large rotating cylinders. It attracted attention wherever it was presented to the public and inspired scientists and engineers to use a rotating cylinder as a lifting device for aircraft. This article reviews the application of Magnus effect devices and concepts in aeronautics that have been investigated by various researchers and concludes with discussions on future challenges in their application.

  4. On the history of dissociative identity disorders in Germany: the doctor Justinus Kerner and the girl from Orlach, or possession as an "exchange of the self".

    PubMed

    Peter, Burkhard

    2011-01-01

    The history of hypnosis is closely linked to the theme of possession; one such link is that the forerunner of hypnosis, animal magnetism, replaced exorcism in 1775 when Franz Anton Mesmer testified against Father Johann Joseph Gassner's exorcism. Modern authors have noted remarkable similarities between states of possession and dissociation. The treatment of possession by animal magnetism and exorcism represents the special romantic-magnetic therapy of the German medical doctor Justinus Kerner in the early 19th century. This article describes the man, his methods, and his thinking and presents one of his most famous case studies, the girl from Orlach, which, by today's standards, was a true case of dissociative identity disorder (DID). This article describes how contemporary principles of treatment were used and controversial issues about the nature and causes of DID were discussed 175 years ago.

  5. Research on data from the ATLAS experiment at CERN

    SciTech Connect

    Purohit, Milind V.

    2015-07-31

    In this report senior investigator Prof. Milind V. Purohit describes research done with data from the ATLAS experiment at CERN. This includes preparing papers on the performance of the CSC detector, searches for SUSY using a new modern ''big data'' technique, and a search for supersymmetry (SUSY) using the "zero leptons razor" (0LRaz) technique. The prediction of the W=Z+jets background processes by the ATLAS simulation prior to the fit is found to be overestimated in the phase space of interest. In all new signal regions presented in this analysis the number of events observed is consistent with the post-fit SM expectations. Assuming R-parity conservation, the limit on the gluino mass exceeds 1150 GeV at 95% confidence level, for an LSP mass smaller than 100 GeV. Other USC personnel who participated in this project during the period of this grant were a graduate student, Anton Kravchenko.

  6. Current rectification in a tropical coral reef system

    NASA Astrophysics Data System (ADS)

    Salas-Monreal, D.; Salas-de-León, D. A.; Monreal-Gómez, M. A.; Riverón-Enzástiga, M. L.

    2009-12-01

    Acoustic Doppler current profiles (ADCP) and conductivity-temperature-depth (CTD) profiles were recorded in the Veracruz Reef System (VRS) to elucidate the effect of topography on current circulation and zooplankton distribution. Measurements showed the baroclinic behavior of the tropical coral reef system with vertical temperature and salinity gradients of 0.4°C m-1 and 0.5 psu m-1, respectively. Under sustained southerly wind conditions, a cyclonic eddy generated by subtidal and tidal current rectification was observed between the two groups of coral colonies studied. Current rectification was attributed to the shallowness of the coral colonies and to a small cape close to Anton Lizardo Village. The cyclonic eddy, with low surface temperature, produced an increment in the vertically integrated acoustic scattering volume (biovolume), suggesting that this is a high-productivity area.

  7. Solubilities of carbon dioxide and nitrous oxide in cyclohexanone, toluene, and N,N-dimethylformamide at elevated pressures

    SciTech Connect

    Chang, C.J.; Chen, C.Y.; Lin, H.C.

    1995-07-01

    The phase behavior of compressed gases in low-volatile solvents has received wide attention in recent years for potential applications in supercritical fluid extraction. The solubilities of carbon dioxide and nitrous oxide in three liquid solvents were measured under static phase equilibrium conditions at temperatures of 290.8, 300.9, and 310.1 K and pressures up to 12.34 MPa. The solubility data were determined from the liquid phase density obtained from an Anton-Paar densitometer, and the level of liquid phase expanded by supercritical and subcritical gases. The solubility of N{sub 2}O in each solvent increased with pressure, but decreased with temperature, and in each case, was greater than that of CO{sub 2}. Both CO{sub 2} and N{sub 2}O showed the highest solubility in cyclohexanone and the least solubility in N,N-dimethylformamide.

  8. Jacques Loeb (1859-1924) and His Forgotten Contributions to Electrolyte and Acid-Base Physiology in The Organism as a Whole.

    PubMed

    Sgambato, Francesco; Sgambato, Ester; De Santo, Natale Gaspare

    2016-02-01

    Jacques Loeb (1859-1924) was the founder of the Journal of General Physiology which he co-directed in association with W.J.V. Osterhout in the years 1918-1924. Having worked (1889-1891)at the Marine Zoological Station of Naples, newly founded by Anton Dohrn, he was imprinted for life. A strong investigator used to perform the experiments personally. Loeb was engaged lifelong in the explanation of life on physico-chemical basis. He touched various fields (being a creative scientist full of ideas), and centered on the exchanges of electrolytes, acids and bases between the body and sea water in fish. He identified two equations: {[K+]+[Na+]}: {[Ca++]+[Mg++]} (Loebs 1st equation) {[K+]+[Na+]}: {[H+]+[Ca++]+[Mg++]} (Loebs final equation) Even nowadays these equations may have applications in a wide list of electrolyte and acid-base disturbances. Unfortunately his heredity has been dissipated.

  9. [Between "aryanization" and liquidation. The fate of the Vienna Psychoanalytic Association after the "Anschluss" in March 1938].

    PubMed

    Rothländer, Christiane

    2008-01-01

    The "Anschluss" of Austria into Hitler-Germany was the temporary end of the Vienna Association (WPV). It was closed by the Gestapo, Hans Ehlich from the SD becoming the special commissioner and the chemist Anton Sauerwald the provisional administrator. The WPV's only chance to avoid losing all its property was to ask their colleagues of the German Psychoanalytic Society (DPG) for help. They were to take over the trusteeship of the WPV and incorporate it into the so-called Goring Institute. Carl Müller-Braunschweig was sent to Vienna as a representative of the DPG. This attempt failed because of the resistance of Rudolf Ramm, head of the Austrian Medical Association, of psychiatrist Heinrich von Kogerer and of Ehlich. In April 1938 Ehlich and Ramm decided on the liquidation of the WPV. PMID:19230390

  10. "Franklin: Science, Politics and France"

    NASA Astrophysics Data System (ADS)

    McClellan, James E., III

    2003-04-01

    This presentation traces Benjamin Franklin's career as a "civic scientist" in Old-Regime France. It outlines the initial - and not always positive - reception of Franklin's work on electricity by the community of French scientists in the 1750s. It sketches Franklin's subsequent elevation into the pantheon of French Enlightenment heros, and it details his work as a "civic scientist" while American envoy to France in the 1770s and 1780s, notably his service on the government-sponsored commissions that repudiated the scientific and medical claims of Franz Anton Mesmer. This presentation concludes by examining a few features of Franklin's career that are not completely congruent with our notion of what a "civic scientist" might be, a contrast that is intended to illuminate both Franklin and the concept of "civic scientist."

  11. [A nosology for supernatural phenomena and the construction of the 'possessed' brain in the nineteenth century].

    PubMed

    Goncalves, Valeria Portugal; Ortega, Francisco

    2013-06-01

    At the end of the twentieth century, supernatural phenomena such as so called trances and possession by spirits received a scientific classification, which includes the numerous diagnoses of the dominant psychiatry. At the end of the nineteenth century we can observe a process of scientific categorization of phenomena considered to have originated in superstition or popular imagination. In this work we show how trances and spiritual possession were studied by Franz Anton Mesmer and his followers when developing the concept of magnetism; by James Braid during the creation of his theory of hypnosis; and by Jean Martin Charcot, which marked the entry of hysteria into nosological classification. Despite the differences between these schools, we identify the use of the brain and cerebral metaphors as the foundation of theories of the mind. PMID:23739806

  12. The power of a musical instrument: Franklin, the Mozarts, Mesmer, and the glass armonica.

    PubMed

    Gallo, D A; Finger, S

    2000-11-01

    In 1761 Benjamin Franklin invented the armonica (often referred to as the glass harmonica), an instrument designed to simplify the playing of the musical glasses. The instrument immediately became popular and inspired compositions by Wolfgang Mozart, who had the opportunity to hear and play one at the house of Franz Anton Mesmer. Armonica music was used by Mesmer in his séances, because he felt it could promote healing by propagating a mystical fluid that he called animal magnetism through the body. After Mesmer's theories were debunked by a highly respected panel of scientists, the armonica fell out of vogue. Because Franklin was on the panel that examined the discredited mesmerism, he indirectly contributed to his own invention's demise.

  13. Quotable physics

    NASA Astrophysics Data System (ADS)

    Chomet, Seweryn

    2008-03-01

    Anton Capri is an alumnus of Princeton University, where he specialized in quantum field theory, and, since 1998, has been a distinguished professor emeritus at the University of Alberta in Canada. Since his nominal retirement he has devoted much of his time to writing and has now published, among other things, two linked books that present a variety of anecdotes involving famous physicists, as well as useful biographical sketches of them. The origin of these books is clearly defined by their author. "I have not any pretensions to having produced a 'scholarly' work," he writes. "Some of the stories recorded here are gossip, or physics folklore. I have tried to verify as many of the stories as I could, but I have not hesitated to include all stories that I heard and noted down."

  14. Corporeal elements and principles in the learned German chymical tradition.

    PubMed

    Klein, Joel A

    2014-11-01

    This paper explores diverse conceptions of the physicality and tangibility of elements and principles in early modern chymistry. By tracing the development of natural philosophical and corpuscular ideas about material elements and principles among several physicans and chymists, including Thomas Erastus, Andreas Libavius, Daniel Sennert, and Anton Günther Billich, this article locates a learned tradition that developed predominantly in Germany, and which directly challenged a common understanding of matter held by major Paracelsians as well as authors from the French textbook tradition. Likewise, conceptions of incorporeal elements or principles are shown to have developed from the ideas of Paracelsus and Petrus Severinus, whereas authors in the learned tradition emphasised a particular interpretation of Aristotle. The article concludes by suggesting that chymical interpretations of material composition had an important influence throughout the seventeenth and eighteenth centuries, and that this provides further evidence that the so-called "compositional revolution" in chemistry was well underway prior to the eighteenth century.

  15. Hidden images of holography: wavefront reconstruction of abnormalities within pulsed holographic recording

    NASA Astrophysics Data System (ADS)

    Richardson, Martin

    2014-02-01

    Unplanned images recorded within holographic space are of candid interest that can reshape audience definition crossing intellectual boundaries. This paper details three examples of off-axis Pulsed Laser transmission holograms that involve holographic portraits. These are movie director Martin Scorsese, former Royal Photographic Society President Mike Austin and a unique recently discovered early pulsed recording of Nick Phillips together with Anton Furst recorded in 1977. Each example was made when operating conditions for the pulsed ruby lasers were optimum, offering a coherence of several meters time-compressed into 25 ns. This gave rise to not only the portrait capture but also others present during the recording session inside the room. This optimum condition captured more than was intended resulting in images that, until now, have remained un-documented.

  16. Bless me reader for I have sinned: physicians and confessional writing.

    PubMed

    Wear, Delese; Jones, Therese

    2010-01-01

    From the poetry of William Carlos Williams, the novels of Walker Percy, and the short stories of Anton Chekov to the contemporary essays of Atul Gawande, physicians' contributions to literary genres have been significant. This article explores the specific form of confessional writing offered by physicians during the past half century, writing that often exposes medical error or negative feelings towards patients. A history of confessional practices as a legal tool, as religious practice, and as literary genre is offered, followed by analyses of selected confessional writings by physicians, many of them found in clinical journals such as Journal of the American Medical Association, Annals of Internal Medicine, and the Lancet. The authors of the narratives described here are engaged in several or all elements of the confessional sequence, which may offer them some resolution through the exposure and acknowledgment of their shared humanity with their patients and their expression of regret for any harm done.

  17. Neuroimaging in alcoholism: ethanol and brain damage.

    PubMed

    Mann, K; Agartz, I; Harper, C; Shoaf, S; Rawlings, R R; Momenan, R; Hommer, D W; Pfefferbaum, A; Sullivan, E V; Anton, R F; Drobes, D J; George, M S; Bares, R; Machulla, H J; Mundle, G; Reimold, M; Heinz, A

    2001-05-01

    This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The co-chairs were Karl Mann and Ingrid Agartz. The presentations were (1) Neuropathological changes in alcohol-related brain damage, by Clive Harper; (2) Regional brain volumes including the hippocampus and monoamine metabolites in alcohol dependence, by Ingrid Agartz, Susan Shoaf, Robert R, Rawlings, Reza Momenan, and Daniel W Hommer; (3) Diffusion tensor abnormalities in imaging of white matter alcoholism, by Adolf Pfefferbaum and Edith V. Sullivan; (4) Use of functional MRI to evaluate brain activity during alcohol cue exposure in alcoholics: Relationship to craving, by Raymond F. Anton, David J. Drobes, and Mark S. George; and (5) mu-Opiate receptor availability in alcoholism: First results from a positron emission tomography study, by Karl Mann, Roland Bares, Hans-Juergen Machulla, Goetz Mundle, Matthias Reimold, and Andreas Heinz.

  18. Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis.

    PubMed

    Ye, Bai-Xin; Deng, Xu; Shao, Li-Dong; Lu, Ying; Xiao, Run; Liu, Yi-Jie; Jin, Yi; Xie, Yin-Yin; Zhao, Yan; Luo, Liu-Fei; Ma, Shun; Gao, Ming; Zhang, Lian-Ru; He, Juan; Zhang, Wei-Na; Chen, Yi; Xia, Cheng-Feng; Deng, Min; Liu, Ting-Xi; Zhao, Qin-Shi; Chen, Sai-Juan; Chen, Zhu

    2015-05-01

    Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation-associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disorders. In this study, we identified vibsanin B, a novel macrocyclic diterpenoid isolated from Viburnum odoratissimum Ker-Gawl, that inhibited zebrafish interstitial leukocyte migration using a transgenic zebrafish line (TG:zlyz-enhanced GFP). We found that vibsanin B preferentially binds to heat shock protein (HSP)90β. At the molecular level, inactivation of HSP90 can mimic vibsanin B's effect of inhibiting interstitial leukocyte migration. Furthermore, we demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS. In summary, vibsanin B is a novel lead compound that preferentially targets HSP90β and inhibits interstitial leukocyte migration, offering a promising drug lead for treating inflammation-associated diseases.

  19. Discrete element simulation of powder compaction in cold uniaxial pressing with low pressure

    NASA Astrophysics Data System (ADS)

    Rojek, Jerzy; Nosewicz, Szymon; Jurczak, Kamila; Chmielewski, Marcin; Bochenek, Kamil; Pietrzak, Katarzyna

    2016-11-01

    This paper presents numerical studies of powder compaction in cold uniaxial pressing. The powder compaction in this work is considered as an initial stage of a hot pressing process so it is realized with relatively low pressure (up to 50 MPa). Hence the attention has been focused on the densification mechanisms at this range of pressure and models suitable for these conditions. The discrete element method employing spherical particles has been used in the numerical studies. Numerical simulations have been performed for two different contact models—the elastic Hertz-Mindlin-Deresiewicz model and the plastic Storåkers model. Numerical results have been compared with the results of laboratory tests of the die compaction of the NiAl powder. Comparisons have shown that the discrete element method is capable to represent properly the densification mechanisms by the particle rearrangement and particle deformation.

  20. Measurement of optical modulation functions in sparsely sampled mosaic focal plane arrays

    NASA Technical Reports Server (NTRS)

    Young, J. B.; Thurlow, P. E.

    1982-01-01

    It is pointed out that the measurement of optical modulation functions for detectors in focal plane arrays may be somewhat more difficult under 'full-up' systems conditions as compared to ideal laboratory conditions. An idealized optical modulation test arrangement is considered along with a full-up scanned system involving an earth mapper in polar orbit. In testing the system in full-up condition, a problem arises with respect to the acquisition of knife edge response data. In order to overcome this problem, a preferred method is developed for obtaining KER data on a single scan. A special 'phased edge' reticle is developed for use in the test set-up. Attention is given to aspects of knife edge reconstruction.

  1. Vitamin A nutritional status of rural community of Khol block in Haryana, North India. A collaborative study.

    PubMed

    Tandon, B N; Ramachandran, K; Nath, L M; Sood, N N; Gahlot, D K; Gupta, M C; Wali, J P; Sinha, S N; Hasteer, P C; Kutty, P R

    1975-12-01

    A nutritional and diet survey was carried out in 2,192 persons belonging to all age groups in a rural community. Vitamin A consumption was less than the recommended daily allowance in persons of all age groups. Bitot's spots and night blindness were detected in 7.1% and 7.2% of the population, respectively. Ocular signs of vitamin A deficiency were more frequently observed in age groups above 5 years as compared to the preschool children. There was no association of vitamin A deficiency with different grades of protein-calorie malnutrition in preschool children. Kerătomalacia was extremely rare and was observed only in one child. The study suggests that the rural area studied was a high prevalence zone for vitamin A deficiency which did not have its serious consequences due to relatively adequate protein-calorie nutritional status of the population.

  2. Panel Discussion I. Star Formation in Galaxies: How Do We Continue?

    NASA Astrophysics Data System (ADS)

    Knapen, J. H.

    2008-06-01

    This is the written account of the first of two panel discussions, on Star formation in galaxies: how do we continue? The chair of the panel was Phil James, and panel members were John Beckman, Torsten Böker, Daniela Calzetti, Angeles Díaz, and Rob Kennicutt. The panel and audience discussed the following four questions: 1) What are the most critically needed techniques to give accurate measurements of total rates and efficiencies of star formation? 2) Do we understand the form of the initial mass function and its variation as a function of redshift and environment? 3) Are there multiple modes of star formation in galaxies (bulge vs disk, burst vs continuous) or does the Schmidt law explain everything? 4) How do we bring together our understanding of star formation in our Galaxy and in external systems?

  3. Eigenvalues of the Neumann Laplacian in symmetric regions

    NASA Astrophysics Data System (ADS)

    Marrocos, Marcus A. M.; Pereira, Antônio L.

    2015-11-01

    In this work, we are concerned with the multiplicity of the eigenvalues of the Neumann Laplacian in regions of ℝn which are invariant under the natural action of a compact subgroup G of O(n). We give a partial positive answer (in the Neumann case) to a conjecture of Arnol'd [Funct. Anal. Appl. 6, 94-101 (1972)] on the transversality of the transformation given by the Dirichlet integral to the stratification in the space of quadratic forms according to the multiplicities of the eigenvalues. We show, for some classes of subgroups of O(n) that, generically in the set of G - invariant, C 2 -regions, the action is irreducible in each eigenspace Ker(Δ + λ). These classes include finite subgroups with irreducible representations of dimension not greater than 2 and, in the case n = 2, any compact subgroup of O(2). We also obtain some partial results for general compact subgroups of O(n).

  4. Observations of toroidicity-induced Alfvén eigenmodes in a reversed field pinch plasma

    NASA Astrophysics Data System (ADS)

    Regnoli, G.; Bergsâker, H.; Tennfors, E.; Zonca, F.; Martines, E.; Serianni, G.; Spolaore, M.; Vianello, N.; Cecconello, M.; Antoni, V.; Cavazzana, R.; Malmberg, J.-A.

    2005-04-01

    High frequency peaks in the spectra of magnetic field signals have been detected at the edge of Extrap-T2R [P. R. Brunsell, H. Bergsåker, M. Cecconello, J. R. Drake, R. M. Gravestijn, A. Hedqvist, and J.-A. Malmberg, Plasma Phys. Controlled Fusion, 43, 1457 (2001)]. The measured fluctuation is found to be mainly polarized along the toroidal direction, with high toroidal periodicity n and Alfvénic scaling (f∝B/√mini ). Calculations for a reversed field pinch plasma predict the existence of an edge resonant, high frequency, high-n number toroidicity-induced Alfvén eigenmode with the observed frequency scaling. In addition, gas puffing experiments show that edge density fluctuations are responsible for the rapid changes of mode frequency. Finally a coupling with the electron drift turbulence is proposed as drive mechanism for the eigenmode.

  5. Pathways for nonsequential and sequential fragmentation of CO2 3 + investigated by electron collision

    NASA Astrophysics Data System (ADS)

    Wang, Enliang; Shan, Xu; Shen, Zhenjie; Gong, Maomao; Tang, Yaguo; Pan, Yi; Lau, Kai-Chung; Chen, Xiangjun

    2015-05-01

    We report nonsequential and sequential fragmentation dynamics of CO2 3 + investigated by electron collision at an impact energy of 500 eV. The dissociation mechanisms are clearly distinguished by combined use of the Dalitz plot together with momentum correlation spectra. The angular distributions and kinetic-energy releases (KERs) of different fragmentation processes are obtained. The dissociation channels of higher excited states of the CO2 3 + molecular ion are opened, which are quite different from the previous studies of heavy-ion collision [N. Neumann, D. Hant, L. Ph. H. Schmidt, J. Titze, T. Jahnke, A. Czasch, M. S. Schöffler, K. Kreidi, O. Jagutzki, H. Schmidt-Böcking, and R. Dörner, Phys. Rev. Lett. 104, 103201 (2010), 10.1103/PhysRevLett.104.103201] and intense laser field [C. Wu, C. Wu, D. Song, H. Su, Y. Yang, Z. Wu, X. Liu, H. Liu, M. Li, Y. Deng, Y. Liu, L.-Y. Peng, H. Jiang, and Q. Gong, Phys. Rev. Lett. 110, 103601 (2013), 10.1103/PhysRevLett.110.103601]. By analyzing KERs together with the help of potential-energy curves exploration at the multireference configuration interaction level, we conclude that the sequential fragmentation occurs in the 2Π ,4Π , and 2Σ+ states of the CO2 3 + ion. The bond length and bond angle are also determined based on the linear fragmentation, indicating that electron impact fragmentation is a potential method to precisely reconstruct the geometry of neutral molecules.

  6. Probing calculated O2+ potential-energy curves with an XUV-IR pump-probe experiment

    NASA Astrophysics Data System (ADS)

    Cörlin, Philipp; Fischer, Andreas; Schönwald, Michael; Sperl, Alexander; Mizuno, Tomoya; Thumm, Uwe; Pfeifer, Thomas; Moshammer, Robert

    2015-04-01

    We study dissociative photoionization of molecular oxygen in a kinematically complete XUV-IR pump-probe experiment. Detecting charged fragments and photoelectrons in coincidence using a reaction microscope, we observe a pump-probe delay-dependent yield of very low energetic O+ ions which oscillates with a period of 40 fs . This feature is caused by a time-dependent vibrational wave packet in the potential of the binding O2+(a Π4u) state, which is probed by resonant absorption of a single infrared photon to the weakly repulsive O2+(f Π4g) state. By quantitative comparison of the experimental kinetic-energy-release (KER) and quantum-beat (QB) spectra with the results of a coupled-channel simulation, we are able to discriminate between the calculated adiabatic O2+ potential-energy curves (PECs) of Marian et al. [Marian, Marian, Peyerimhoff, Hess, Buenker, and Seger, Mol. Phys. 46, 779 (1982), 10.1080/00268978200101591] and Magrakvelidze et al. [Magrakvelidze, Aikens, and Thumm, Phys. Rev. A 86, 023402 (2012), 10.1103/PhysRevA.86.023402]. In general, we find a good agreement between experimental and simulated KER and QB spectra. However, we could not reproduce all features of the experimental data with these PECs. In contrast, adjusting a Morse potential to the experimental data, most features of the experimental spectra are well reproduced by our simulation. By comparing this Morse potential to theoretically predicted PECs, we demonstrate the sensitivity of our experimental method to small changes in the shape of the binding potential.

  7. Neurofilament-tubulin binding site peptide NFL-TBS.40-63 increases the differentiation of oligodendrocytes in vitro and partially prevents them from lysophosphatidyl choline toxiciy.

    PubMed

    Fressinaud, Catherine; Eyer, Joël

    2014-02-01

    During multiple sclerosis (MS), the main axon cystoskeleton proteins, neurofilaments (NF), are altered, and their release into the cerebrospinal fluid correlates with disease severity. The role of NF in the extraaxonal location is unknown. Therefore, we tested whether synthetic peptides corresponding to the tubulin-binding site (TBS) sequence identified on light NF chain (NFL-TBS.40-63) and keratin (KER-TBS.1-24), which could be released during MS, modulate remyelination in vitro. Biotinylated NFL-TBS.40-63, NFL-Scramble2, and KER-TBS.1-54 (1-100 μM, 24 hr) were added to rat oligodendrocyte (OL) and astrocyte (AS) cultures, grown in chemically defined medium. Proliferation and differentiation were characterized by using specific antibodies (A2B5, CNP, MBP, GFAP) and compared with untreated cultures. Lysophosphatidyl choline (LPC; 2 × 10(-5) M) was used to induce OL death and to test the effects of TBS peptides under these conditions. NFL-TBS.40-63 significantly increased OL differentiation and maturation, with more CNP(+) and MBP(+) cells characterized by numerous ramified processes, along with myelin balls. When OL were challenged with LPC, concomitant treatment with NFL-TBS.40-63 rescued more than 50% of OL compared with cultures treated with LPC only. Proliferation of OL progenitors was not affected, nor were AS proliferation and differentiation. NFL-TBS.40-63 peptide induces specific effects in vitro, increasing OL differentiation and maturation without altering AS fate. In addition, it partially protects OL from demyelinating injury. Thus release of NFL-TBS.40-63 caused by axonal damage in vivo could improve repair through increased OL differentiation, which is a prerequisite for remyelination.

  8. Investigation of electronically excited indole relaxation dynamics via photoionization and fragmentation pump-probe spectroscopy.

    PubMed

    Godfrey, T J; Yu, Hui; Ullrich, Susanne

    2014-07-28

    The studies herein investigate the involvement of the low-lying (1)La and (1)Lb states with (1)ππ(*) character and the (1)πσ(*) state in the deactivation process of indole following photoexcitation at 201 nm. Three gas-phase, pump-probe spectroscopic techniques are employed: (1) Time-resolved photoelectron spectroscopy (TR-PES), (2) hydrogen atom (H-atom) time-resolved kinetic energy release (TR-KER), and (3) time-resolved ion yield (TR-IY). Each technique provides complementary information specific to the photophysical processes in the indole molecule. In conjunction, a thorough examination of the electronically excited states in the relaxation process, with particular focus on the involvement of the (1)πσ(*) state, is afforded. Through an extensive analysis of the TR-PES data presented here, it is deduced that the initial excitation of the (1)Bb state decays to the (1)La state on a timescale beyond the resolution of the current experimental setup. Relaxation proceeds on the (1)La state with an ultrafast decay constant (<100 femtoseconds (fs)) to the lower-lying (1)Lb state, which is found to possess a relatively long lifetime of 23 ± 5 picoseconds (ps) before regressing to the ground state. These studies also manifest an additional component with a relaxation time of 405 ± 76 fs, which is correlated with activity along the (1)πσ(*) state. TR-KER and TR-IY experiments, both specifically probing (1)πσ(*) dynamics, exhibit similar decay constants, further validating these observations.

  9. Investigation of electronically excited indole relaxation dynamics via photoionization and fragmentation pump-probe spectroscopy

    SciTech Connect

    Godfrey, T. J.; Yu, Hui; Ullrich, Susanne

    2014-07-28

    The studies herein investigate the involvement of the low-lying {sup 1}L{sub a} and {sup 1}L{sub b} states with {sup 1}ππ{sup *} character and the {sup 1}πσ{sup *} state in the deactivation process of indole following photoexcitation at 201 nm. Three gas-phase, pump-probe spectroscopic techniques are employed: (1) Time-resolved photoelectron spectroscopy (TR-PES), (2) hydrogen atom (H-atom) time-resolved kinetic energy release (TR-KER), and (3) time-resolved ion yield (TR-IY). Each technique provides complementary information specific to the photophysical processes in the indole molecule. In conjunction, a thorough examination of the electronically excited states in the relaxation process, with particular focus on the involvement of the {sup 1}πσ{sup *} state, is afforded. Through an extensive analysis of the TR-PES data presented here, it is deduced that the initial excitation of the {sup 1}B{sub b} state decays to the {sup 1}L{sub a} state on a timescale beyond the resolution of the current experimental setup. Relaxation proceeds on the {sup 1}L{sub a} state with an ultrafast decay constant (<100 femtoseconds (fs)) to the lower-lying {sup 1}L{sub b} state, which is found to possess a relatively long lifetime of 23 ± 5 picoseconds (ps) before regressing to the ground state. These studies also manifest an additional component with a relaxation time of 405 ± 76 fs, which is correlated with activity along the {sup 1}πσ{sup *} state. TR-KER and TR-IY experiments, both specifically probing {sup 1}πσ{sup *} dynamics, exhibit similar decay constants, further validating these observations.

  10. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the identification of environmental organisms: the Planctomycetes paradigm.

    PubMed

    Cayrou, Caroline; Raoult, Didier; Drancourt, Michel

    2010-12-01

    We have developed a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based identification technique for Planctomycetes organisms, which are used here as bacteria of suitable diversity at genus and species level for testing resolution of the method. Planctomyces maris ATCC 29201, Planctomyces brasiliensis ATCC 49424(T) , P. brasiliensis ATCC 49425, Planctomyces limnophilus ATCC 43296(T) , Blastopirellula marina ATCC 49069(T) , Rhodopirellula baltica DSM 10527(T) and Gemmata obscuriglobus DSM 5831(T) were cultured on half-strength marine broth and agar, or alternatively on caulobacter broth and agar. The resulting pellets of organisms (liquid) or colonies (solid agar) were directly applied to a MALDI-TOF plate. This yielded a reproducible, unique protein profiles comprising 23-39 peaks ranging in size from 2403 to 12 091 Da. These peaks were unambiguously distinguished from any of the 3038 bacterial spectra in the Brüker database. Matrix-assisted laser desorption/ionization time-of-flight patterns were similar for isolates grown in solid and in liquid medium, albeit the patterns from solid growth were more easily interpretable. After the incorporation of the herein determined profiles into the Brüker database, Planctomycetes isolates were blindly identified within 10 min, with an identification score in the range of 1.8 to 2.3. Matrix-assisted laser desorption/ionization time-of-flight-based clustering of these Planctomycetes organisms was consistent with 16S rDNA-based phylogeny. However, the incorporation of additional non-Planctomycetes MALDI-TOF profiles in the analysis resulted in inconsequential clustering. In conclusion, MALDI-TOF protein profiling is a new approach for the rapid and accurate identification of cultured environmental organisms, as illustrated in this study through the analysis of Planctomycetes. PMID:23766281

  11. The Zach family in Hungary

    NASA Astrophysics Data System (ADS)

    Vargha, Magda

    The Zach Family moved to Hungary. In the first decades of the 18th century the population was so low in Hungary that thousands of people moved into an almost empty country. In 1740 the physician Joseph Zach (1714-1792) came from Moravia to Esztergom which at that time had only 10 000 inhabitants. Soon he became the city doctor. It is very probable, that this was the place where he met Klara Sonntag, who became his wife. In any case, Zach moved to Pest, where he became the city doctor in 1746. The Invalide-Hospital built by Martinelli in 1726 was the biggest and most elegant house in Pest at that time - and it was giving shelter to 4000 invalids, whilst the city itself had only 11 000 inhabitants. There Zach became the ``protomedicus''. In 1751 Austrian Empress Maria Theresia visited this military hospital. She was so impressed by Zach's work that she honoured him with Hungarian nobility in 1765. From the corresponding official paper we know that he had three sons and three daughters. In 1791 he received citizenship in Pest. The Hungarian Magnates favoured the talented physician. The Lord Chief Justice Count György Fekete was also among his patients. His thirteen year-old son Count János Fekete became the godfather of Zach's son Franz Xaver Zach in 1754. It is very likely that Voltairian Count János Fekete influenced the personality of Franz Xaver von Zach. Galicia became Austrian Territory in 1772. Pater Liesganig was nominated to lead the Land-Survey Office of Galicia. Anton von Zach and Franz Xaver Zach were his co-workers in this very important task. At the same time Franz Zach became a professor of mechanics at Lemberg University and in its observatory he began his life-long astronomical observations. It is very probable that he joined the Freemasons here together with his godfather, now General, Jänos Fekete. Later they stayed in the same cities very often. The military and scientific works of the two Zach brothers Anton and Franz were so highly

  12. Mapping the isotopic signature of methane in South-Eastern Spain: complementing biogeochemical long-term research with short term observations

    NASA Astrophysics Data System (ADS)

    Àgueda, Alba; Morguí, Josep Anton; Vazquez Garcia, Eusebi; Curcoll, Roger; Lowry, David; Fisher, Rebecca E.; Nisbet, Euan G.

    2016-04-01

    will be helpful in the validation of transport models. *Corresponding author: Josep Anton Morguí - josep-anton.morgui@ic3.cat "The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) in the InGOS project under grant agreement n° 284274''

  13. Nephrological excerpts from the Encyclopédie of Diderot and d'Alembert.

    PubMed

    De Santo, Natale Gaspare; Cirillo, Massimo; Bisaccia, Carmela; Richet, Gabriel; Eknoyan, Garabed

    2011-05-01

    The Encyclopédie of Denis Diderot (1713-1784) and Jean-Baptiste le Rond d'Alembert (1717-1783), a 35-volume work published between 1751 and 1780, is the most representative work of the Enlightenment in France. Written to explain truths based on experiment, detected by the senses, and analyzed by reason, it was meant to be an inclusive systematic dictionary of the sciences, arts, and crafts. Medicine, considered an experimental but practical science based on measurement, is not mentioned in the frontispiece, but is covered in the text based on the work of several illustrious scientists and clinicians of the period. The renal entries describe kidney structure and function, normal and pathologic urine, diabetes, anuria, polyuria, dysuria, stranguria, incontinence, kidney stones, edema, diuretics, and nephritis. The contributions of Marcello Malpighi (1628-1698), Herman Boerhaave (1668-1738), and Guichard-Joseph Duverney (1648-1730) are highlighted. Accompanying illustrations of unique perfection show the position of the kidneys according to Albrecht Haller (1708-1777); their innervation according to Raymond Vieussens (1641-1715); their structure according to Anton Nuck (1650-1692), Exupère Joseph Bertin (1712-1781), and Frederick Ruysch (1638-1731); and the genitourinary tract according to Duverney. Overall, the Encyclopédie provides a unique summary of what was known about kidney structure, function, and disease in the 18th century.

  14. Preparation and properties of environmental-friendly coatings based on carboxymethyl cellulose nitrate ester & modified alkyd.

    PubMed

    Duan, Hongtao; Shao, Ziqiang; Zhao, Ming; Zhou, Zhenwen

    2016-02-10

    Amphipathic coating basic film-forming material carboxymethyl cellulose nitrate ester (CMCN) was synthesized and characterizations of CMCN with different ratio of functional groups were studied. Ratios of functional groups on each repeating units of CMCN have great importance in the decision of CMCN properties using as an amphipathic coating basic film-forming material and ratios of functional groups were the most concerned of the study. Ratios of functional groups on each repeating units of CMCN were measured by elemental analyzer and calculated. Series of experiments were conducted using different ratios of functional groups of CMCN. Thermal properties of CMCN were measured by FT-IR and TG. Densities of CMCN powders were measured. Aqueous coatings based on CMCN/alkyd (after chemical modified by coconut oil) were prepared and morphology & rheology of CMCN hydrophilic dispersions were measured using an Anton-Paar-Strasse 20A-8054 Graz analyzer. Contact angles between films based on CMCN and deionized water were recorded. Other properties of films were measured. CMCN with the etherification of carboxymethyl groups at 0.35-0.40, nitrate ester groups at 1.96-2.19 and hydroxyl groups at 0.46-0.64 per d-glucose was considered as the best film forming material.

  15. Present at the creation: the clinical pastoral movement and the origins of the dialogue between religion and psychiatry.

    PubMed

    Hart, Curtis W; Div, M

    2010-12-01

    The contemporary dialogue between religion and psychiatry has its roots in what is called the clinical pastoral movement. The early leaders of the clinical pastoral movement (Anton Boisen, Elwood Worcester, Helen Flanders Dunbar, and Richard Cabot) were individuals of talent, even genius, whose lives and work intersected one another in the early decades of the twentieth century. Their legacy endures in the persons they inspired and continue to inspire and in the professional organizations and academic programs that profit from their pioneering work. To understand them and the era of their greatest productivity is to understand some of what psychiatry and religion have to say to each other. Appreciating their legacy requires attention to the context of historical movements and forces current in America at the end of the nineteenth and the beginning of the twentieth century that shaped religious, psychiatric, and cultural discourse. This essay attempts to provide an introduction to this rich and fascinating material. This material was first presented as a Grand Rounds lecture at The New York Presbyterian Hospital, Payne Whitney Westchester in the Department of Psychiatry, Weill Cornell Medical College.

  16. The Impact of a Ligand Binding on Strand Migration in the SAM-I Riboswitch

    PubMed Central

    Huang, Wei; Kim, Joohyun; Jha, Shantenu; Aboul-ela, Fareed

    2013-01-01

    Riboswitches sense cellular concentrations of small molecules and use this information to adjust synthesis rates of related metabolites. Riboswitches include an aptamer domain to detect the ligand and an expression platform to control gene expression. Previous structural studies of riboswitches largely focused on aptamers, truncating the expression domain to suppress conformational switching. To link ligand/aptamer binding to conformational switching, we constructed models of an S-adenosyl methionine (SAM)-I riboswitch RNA segment incorporating elements of the expression platform, allowing formation of an antiterminator (AT) helix. Using Anton, a computer specially developed for long timescale Molecular Dynamics (MD), we simulated an extended (three microseconds) MD trajectory with SAM bound to a modeled riboswitch RNA segment. Remarkably, we observed a strand migration, converting three base pairs from an antiterminator (AT) helix, characteristic of the transcription ON state, to a P1 helix, characteristic of the OFF state. This conformational switching towards the OFF state is observed only in the presence of SAM. Among seven extended trajectories with three starting structures, the presence of SAM enhances the trend towards the OFF state for two out of three starting structures tested. Our simulation provides a visual demonstration of how a small molecule (<500 MW) binding to a limited surface can trigger a large scale conformational rearrangement in a 40 kDa RNA by perturbing the Free Energy Landscape. Such a mechanism can explain minimal requirements for SAM binding and transcription termination for SAM-I riboswitches previously reported experimentally. PMID:23704854

  17. Projected and hidden Markov models for calculating kinetics and metastable states of complex molecules.

    PubMed

    Noé, Frank; Wu, Hao; Prinz, Jan-Hendrik; Plattner, Nuria

    2013-11-14

    Markov state models (MSMs) have been successful in computing metastable states, slow relaxation timescales and associated structural changes, and stationary or kinetic experimental observables of complex molecules from large amounts of molecular dynamics simulation data. However, MSMs approximate the true dynamics by assuming a Markov chain on a clusters discretization of the state space. This approximation is difficult to make for high-dimensional biomolecular systems, and the quality and reproducibility of MSMs has, therefore, been limited. Here, we discard the assumption that dynamics are Markovian on the discrete clusters. Instead, we only assume that the full phase-space molecular dynamics is Markovian, and a projection of this full dynamics is observed on the discrete states, leading to the concept of Projected Markov Models (PMMs). Robust estimation methods for PMMs are not yet available, but we derive a practically feasible approximation via Hidden Markov Models (HMMs). It is shown how various molecular observables of interest that are often computed from MSMs can be computed from HMMs/PMMs. The new framework is applicable to both, simulation and single-molecule experimental data. We demonstrate its versatility by applications to educative model systems, a 1 ms Anton MD simulation of the bovine pancreatic trypsin inhibitor protein, and an optical tweezer force probe trajectory of an RNA hairpin. PMID:24320261

  18. Projected and hidden Markov models for calculating kinetics and metastable states of complex molecules

    NASA Astrophysics Data System (ADS)

    Noé, Frank; Wu, Hao; Prinz, Jan-Hendrik; Plattner, Nuria

    2013-11-01

    Markov state models (MSMs) have been successful in computing metastable states, slow relaxation timescales and associated structural changes, and stationary or kinetic experimental observables of complex molecules from large amounts of molecular dynamics simulation data. However, MSMs approximate the true dynamics by assuming a Markov chain on a clusters discretization of the state space. This approximation is difficult to make for high-dimensional biomolecular systems, and the quality and reproducibility of MSMs has, therefore, been limited. Here, we discard the assumption that dynamics are Markovian on the discrete clusters. Instead, we only assume that the full phase-space molecular dynamics is Markovian, and a projection of this full dynamics is observed on the discrete states, leading to the concept of Projected Markov Models (PMMs). Robust estimation methods for PMMs are not yet available, but we derive a practically feasible approximation via Hidden Markov Models (HMMs). It is shown how various molecular observables of interest that are often computed from MSMs can be computed from HMMs/PMMs. The new framework is applicable to both, simulation and single-molecule experimental data. We demonstrate its versatility by applications to educative model systems, a 1 ms Anton MD simulation of the bovine pancreatic trypsin inhibitor protein, and an optical tweezer force probe trajectory of an RNA hairpin.

  19. Spatial distribution of 0-group eel larvae ( Anguilla sp.) in the Sargasso Sea

    NASA Astrophysics Data System (ADS)

    Schoth, M.; Tesch, F.-W.

    1982-09-01

    Both Atlantic eel species ( Anguilla anguilla and A. rostrata) were collected in the Sargasso Sea during the 1979 cruise of the F. R. V. “Anton Dohrn” and R. V. “Friedrich Heincke”. A total of 3,097 0-group larvae were caught during 80 hauls using the Isaacs Kidd Midwater Trawl (55 hauls) and the 9-fold opening and closing net MOCNESS (25 hauls). 11 hauls of the MOCNESS indicated that the larvae showed a preference for the 150 175 m water depth during daytime and for the 50 75 m depth during night. The northern distribution limit seems to coincide with the “18°C-water” at the sea surface. The Antilla current characterised by higher temperatures and salinities could have been the southern distribution limit. The north-easternmost occurrence of A. anguilla was noted at 50°W; the eastern distribution limit of this species could be farther east. The westernmost station at 69°W was positive for both species. A. anguilla, therefore, is very likely to occur beyond this area. The easternmost occurrence of A. rostrata was noted at 52°W though sporadic and with increasing abundance towards the west. At the western end of the network of stations the highest concentration of larvae from both species was recorded. Oceanographic investigations reveal that the distribution of the smaller larvae (size-groups <7 mm and <10 mm) almost coincides with the assumed spawning area.

  20. The earliest telescope preserved in Japan

    NASA Astrophysics Data System (ADS)

    Nakamura, Tsuko

    2008-11-01

    This paper describes the antique telescope owned by one of Japan's major feudal warlords, Tokugawa Yoshinao. As he died in 1650, this means that this telescope was produced in or before that year. Our recent investigation of the telescope revealed that it is of Schyrlean type, consisting of four convex lenses, so that it gives erect images with a measured magnifying power of 3.9 (± 0.2-0.3). This also implies that Yoshinao's telescope could be one of the earliest Schyrlean telescopes ever. The design, fabrication technique, and the surface decoration of the telescopic tube and caps all suggest that it is not a Western make at all, but was produced probably under the guidance of a Chinese Jesuit missionary or by the Chinese, in Suzhou or Hangzhou in Zhejiang province, China, or in Nagasaki. Following descriptions in the Japanese and Chinese historical literature, we also discuss the possibility that production of Schyrlean-type telescopes started independently in the Far East nearly simultaneously with the publication of Oculus Enoch et Eliae by Anton Maria Schyrle in 1645.

  1. Lab experiments on the innovative rapid thick strip casting process

    NASA Astrophysics Data System (ADS)

    Nagy, Richard; Senk, Dieter

    2012-05-01

    Rapid thick strip casting (RTSC) by Anton Hulek, Inventmetall®, is an innovative concept for the production of hot strips with a final as-cast thickness of about 25 mm before rolling. The innovation of the mechanism consists in a vertical mould performing a caterpillar motion. This moving mould has an unconventional parallelogram-shaped cross-section. The conventional rectangular shape is formed in the shaping machine, which is placed straight below the mould. Further elements of the technology are state-of-the-art. For the investigation of this new casting system theoretical calculations were complemented with practical experiments. The investigation focused mainly on two key aspects: the characteristics of the mould and the shaping process. For the practical analysis a static mould with three pairs of elements in laboratory scale was developed and commissioned by the Dept. of Ferrous Metallurgy @ RWTH Aachen University. The shaping experiments were carried out in model scale with two different materials and in variable boundary conditions. The results of these experiments delivered important mechanical as well as thermal informations about the casting system.

  2. [Visual perception deficits of cortical origin].

    PubMed

    Stolarska, Urszula; Zajac, Anna; Skowronek-Bała, Barbara; Budziszewska, Bogusława

    2009-01-01

    This work comprises of a literature review on visual perception distortions that have their origin in structural or functional irregularities of the brain, resulting in the cortex malfunction. The main area that we pay attention to is the brain cortex, but we should not forget, that diseases destructive to the lower brain structures also inevitably lead to secondary dysfunction of the cortex, and thus they have also been included in this paper. Cerebral vision disorders are a small percentage of caseload in either neurology or ophthalmology practice, yet they certainly are interesting for the cognitive scientists, as they open a window into the complex mechanisms of the cerebral clockwork. We are presenting examples of disorders, many of which engage the creative cooperation between specialists from different fields of neuroscience. Three kinds of disorders are presented: vision loss, agnosias and hallucinations. Among others there is some information on cortical blindness, blindsight, Anton's syndrome, hysterical blindness, apperceptive and associative agnosia, prosopagnosia, pure alexia, achromatopsia, Bonnet syndrome, Alice in Wonderland syndrome, peduncular halucinosis etc. PMID:20297642

  3. The effect of temperature on rheological properties of endodontic sealers

    PubMed Central

    Rai, Roshni U.; Singbal, Kiran P.; Parekh, Vaishali

    2016-01-01

    Aim: The purpose of this study was to investigate temperature-dependent rheological properties of three endodontic sealers MTA Fillapex (Angelus, Brazil), AH Plus (Dentsply, Germany), and EndoREZ (Ultradent, USA). Materials and Methods: Five samples of each group of endodontic sealers (n = 30) were freshly mixed and placed on the plate of a rheometer (MCR 301, AntonPaar, Physica) and examined at 25°C and 37°C temperature, respectively. Rheological properties of the sealers were calculated according to the loss modulus (G″), storage modulus (G′), loss factor (Tan δ), and complex viscosity (η*) using dynamic oscillatory shear tests. Results: Statistical analysis (Wilcoxon signed-rank test) demonstrated that MTA Fillapex exhibited higher loss modulus (G″ > G′) and a crossover region. AH Plus and EndoREZ had a higher storage modulus (G′ > G″) at both temperatures. Loss factor (Tan δ) of MTA Fillapex was the highest compared to AH Plus, followed by EndoREZ. With a temperature change from 25°C to 37°C, MTA Fillapex exhibited a decrease while AH Plus exhibited an increase and, EndoREZ exhibited the least change, in complex viscosity (η*). Conclusions: EndoREZ exhibited better rheological properties compared to the other two test sealers. PMID:27099414

  4. Folding simulations for proteins with diverse topologies are accessible in days with a physics-based force field and implicit solvent.

    PubMed

    Nguyen, Hai; Maier, James; Huang, He; Perrone, Victoria; Simmerling, Carlos

    2014-10-01

    The millisecond time scale needed for molecular dynamics simulations to approach the quantitative study of protein folding is not yet routine. One approach to extend the simulation time scale is to perform long simulations on specialized and expensive supercomputers such as Anton. Ideally, however, folding simulations would be more economical while retaining reasonable accuracy, and provide feedback on structure, stability and function rapidly enough if partnered directly with experiment. Approaches to this problem typically involve varied compromises between accuracy, precision, and cost; the goal here is to address whether simple implicit solvent models have become sufficiently accurate for their weaknesses to be offset by their ability to rapidly provide much more precise conformational data as compared to explicit solvent. We demonstrate that our recently developed physics-based model performs well on this challenge, enabling accurate all-atom simulated folding for 16 of 17 proteins with a variety of sizes, secondary structure, and topologies. The simulations were carried out using the Amber software on inexpensive GPUs, providing ∼1 μs/day per GPU, and >2.5 ms data presented here. We also show that native conformations are preferred over misfolded structures for 14 of the 17 proteins. For the other 3, misfolded structures are thermodynamically preferred, suggesting opportunities for further improvement. PMID:25255057

  5. Rheological Properties of Nanoparticle Silica-Surfactant Stabilized Crude Oil Emulsions: Influence of Temperature, Nanoparticle Concentration and Water Volume Fraction"

    NASA Astrophysics Data System (ADS)

    Kinsey, Erin; Pales, Ashley; Li, Chunyan; Mu, Linlin; Bai, Lingyun; Clifford, Heather; Darnault, Christophe

    2016-04-01

    Oil in water emulsions occur during oil extraction due to the presence of water, naturally-occurring surface-active agents and mechanical mixing in pipelines or from oil spillage. Emulsions present difficulties for use of oil in fuel and their rheological properties are important to treat environmental impacts of spills. The objective of this study is to assess the rheological characteristics of oil in water emulsions stabilized by 5% NaCl brine, Tween 20 surfactant and silica nanoparticles to gain knowledge about the behavior of oil flow in pipelines and characterize them for environmental applications. Rheological behaviors such as shear rate, shear stress, and viscosity of Prudhoe Bay crude oil emulsions were analyzed with varying percent of water volume fractions (12.5, 25 and 50%), varying weight percent of silica nanoparticles (0.001, 0.01 and 0.1 weight %), with and without 2 CMC Tween 20 nonionic surfactant. Emulsions with varying water volume fractions were analyzed at 20, 40 and 60 degrees Celsius. Flow curve analysis of the emulsions was performed using an Anton-Paar rheometer. Preliminary findings indicate that increased temperature and increasing the concentration of nanoparticles both produced lower shear stress and that the addition of surfactant decreased the viscosity and shear stress of the emulsions.

  6. Dancing with chemical formulae of antivirals: A panoramic view (Part 2).

    PubMed

    De Clercq, Erik

    2013-11-15

    In this second part of "Dancing with antivirals as chemical formulae" I will focus on a number of chemical compounds that in the last few years have elicited more than common attraction from a commercial viewpoint: (i) favipiravir (T-705), as it is active against influenza, but also several other RNA viruses; (ii) neuraminidase inhibitors such as zanamivir and oseltamivir; (iii) peramivir and laninamivir octanoate, which might be effective against influenza virus following a single (intravenous or inhalation) administration; (iv) sofosbuvir, the (anticipated) cornerstone for the interferon-free therapy of HCV infections; (v) combinations of DAAs (direct antiviral agents) to achieve, in no time, a sustained virus response (SVR) against HCV infection; (vi) HIV protease inhibitors, the latest and most promising being darunavir; (vii) the integrase inhibitors (INIs) (raltegravir, elvitegravir, dolutegravir), representing a new dimension in the anti-HIV armamentarium; (viii), a new class of helicase primase inhibitors (HPIs) that may exceed acyclovir and the other anti-herpes compounds in both potency and safety; (ix) CMX-001, as the latest of Dr. Antonín Holý's legacy for its activity against poxviruses and CMV infections, and (x) noroviruses for which the ideal antiviral compounds are still awaited for.

  7. The design and analysis of new musical bells

    NASA Astrophysics Data System (ADS)

    McLachlan, Neil M.

    2001-05-01

    The design and analysis of a series of new musical bells will be presented in this paper. Modal analysis of a wide range of bell-like geometries using FEA revealed the presence and significance of transverse axial modes in unconstrained bell models, leading to a new understanding of the relationships between bell geometry and modal behavior. This understanding was used to adjust simple parametric models of bell geometry to arrive at appropriate geometries to begin numerical shape optimization for the design of bells with a range of desired overtone tunings. Pitch salience is well known to depend on the degree of harmonic relationships between pure tones in complex stimuli. Bells intended to produce a single, highly salient pitch were designed and manufactured with up to the first 7 overtones tuned to the harmonic series. Other bells with overtones tuned to subsets of two or three harmonic series were also designed and manufactured. These bells were intended to produce multiple pitch perceptions of approximately equal strength. Spectral analysis and range of numerical psycho-acoustic models are used to evaluate the sounds of manufactured bells against these design objectives. [I would like to acknowledge the close collaboration of Dr. Anton Hasell of Australian Bell.

  8. Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex

    PubMed Central

    Raveh, Barak; Karp, Jerome M.; Sparks, Samuel; Rout, Michael P.; Sali, Andrej; Cowburn, David

    2016-01-01

    Nucleocytoplasmic transport is mediated by the interaction of transport factors (TFs) with disordered phenylalanine-glycine (FG) repeats that fill the central channel of the nuclear pore complex (NPC). However, the mechanism by which TFs rapidly diffuse through multiple FG repeats without compromising NPC selectivity is not yet fully understood. In this study, we build on our recent NMR investigations showing that FG repeats are highly dynamic, flexible, and rapidly exchanging among TF interaction sites. We use unbiased long timescale all-atom simulations on the Anton supercomputer, combined with extensive enhanced sampling simulations and NMR experiments, to characterize the thermodynamic and kinetic properties of FG repeats and their interaction with a model transport factor. Both the simulations and experimental data indicate that FG repeats are highly dynamic random coils, lack intrachain interactions, and exhibit significant entropically driven resistance to spatial confinement. We show that the FG motifs reversibly slide in and out of multiple TF interaction sites, transitioning rapidly between a strongly interacting state and a weakly interacting state, rather than undergoing a much slower transition between strongly interacting and completely noninteracting (unbound) states. In the weakly interacting state, FG motifs can be more easily displaced by other competing FG motifs, providing a simple mechanism for rapid exchange of TF/FG motif contacts during transport. This slide-and-exchange mechanism highlights the direct role of the disorder within FG repeats in nucleocytoplasmic transport, and resolves the apparent conflict between the selectivity and speed of transport. PMID:27091992

  9. The astrological roots of mesmerism.

    PubMed

    Schaffer, Simon

    2010-06-01

    Franz Anton Mesmer's 1766 thesis on the influence of the planets on the human body, in which he first publicly presented his account of the harmonic forces at work in the microcosm, was substantially copied from the London physician Richard Mead's early eighteenth century tract on solar and lunar effects on the body. The relation between the two texts poses intriguing problems for the historiography of medical astrology: Mesmer's use of Mead has been taken as a sign of the Vienna physician's enlightened modernity while Mead's use of astro-meteorology has been seen as evidence of the survival of antiquated astral medicine in the eighteenth century. Two aspects of this problem are discussed. First, French critics of mesmerism in the 1780s found precedents for animal magnetism in the work of Paracelsus, Fludd and other early modern writers; in so doing, they began to develop a sophisticated history for astrology and astro-meteorology. Second, the close relations between astro-meteorology and Mead's project illustrate how the environmental medical programmes emerged. The making of a history for astrology accompanied the construction of various models of the relation between occult knowledge and its contexts in the enlightenment.

  10. Meeting report: 26th International Conference on Antiviral Research.

    PubMed

    Vere Hodge, R Anthony

    2013-10-01

    The 26th International Conference on Antiviral Research (ICAR) was held in San Francisco, California from May 11 to 15, 2013. This article summarizes the principal invited lectures at the meeting. The opening symposium on the legacy of the late Antonín Holý included presentations on his pioneering work with nucleotide analogs, which led to the development of several antiviral drugs including tenofovir. This drug has transformed the treatment of HIV infection and has recently become the first-line therapy for chronic hepatitis B. The Gertrude Elion Award lecturer described the anti-HIV activities of the CCR5 inhibitor cenicriviroc and the reverse transcriptase inhibitor festinavir®, and also reviewed the evaluation of biodegradable nanoparticles with adjuvant activity. The William Prusoff Award winner reported on the creation of NAOMI, a computer model with 21 enzymes to predict the activity of nucleoside analogs against hepatitis C virus (HCV). Other invited lecturers discussed the development of countermeasures against severe dengue and the potential of RNA virus capping and repair enzymes as drug targets. Topics in the clinical symposium included the current status of the anti-HCV compounds sovaprevir, ACH-3102, miravirsen and ALS-2200; the evaluation of single-tablet regimens for HIV infection; and the investigation of cytomegalovirus resistance to CMX001. Two chemistry minisymposia examined strategies and tactics in drug design and the use of in drug discovery. PMID:23973733

  11. Helgoland und die Erforschung der marinen Benthosalgen

    NASA Astrophysics Data System (ADS)

    Mollenhauer, D.; Lüning, K.

    1988-09-01

    Early phycological research on the island of Helgoland was performed by amateur phycologists from the adjacent coastal regions of Germany (Bremen, Hamburg, Lower Saxony and Schleswig-Holstein). These pioneers were followed by professionals, and by collectors from the mainland universities, particularly from Berlin. This second phase group includes the naturalist Christian Gottfried Ehrenberg, the zoologists Johannes Müller, Ernst Haeckel and Anton Dohrn, and the botanists Alexander Braun, Nathanael Pringsheim, and Ferdinand Cohn. The leading marine phycologist in Germany, towards the end of the 19th century, was Johannes Reinke, who finally worked at the University of Kiel. Paul Kuckuck's doctoral thesis had been supervised by Reinke who recommended him for the post of the first curator of botany at the Biological Station of Helgoland, which was founded in 1892. Kuckuck worked on the island from 1892 to 1914. After World War I, and after Kuckuck's untimely death, Wilhelm Nienburg became the second curator of botany on Helgoland, from 1921 to 1923. The next permanent phycologist on the island, from 1925 to 1936, was Ernst Schreiber. He was followed in 1936 by Peter Kornmann, who retired in 1972 but still continues as a research worker, together with Paul-Heinz Sahling, who started to work as a technical assistant under the guidance of Ernst Schreiber in 1927.

  12. [Music therapy in the behavior therapeutic combined treatment concept. Comparison between alcoholics with neurotic personality structure and patients with behavior disturbances].

    PubMed

    Formann-Radl, I

    1980-01-01

    From times immemorial, music closely associating with magic, played a significant part in the art of healing and in religion itself. It is not an invention of modern technical age and today it is legitimately involved in the overall rehabilitation programms in psychiatry. We have therefore attempted to conduct a study on this subject. The present investigation compares the behaviour of 100 alcoholics and 100 patients with neurotic personality disturbances drawn from the catchment areas of the Psychiatric University Clinic Vienna/Austria and the Anton-Proksch-Institut in Vienna-Kalksburg with regard to their respone to this type of therapy. We found that music provides a substantial contribution in reinforcing the basic ethical concept of the person concerned. It also breaks the barriere of expressivity by enriching the pool fo potential vocabulary. It appears to be the ideal medium of free communication. Investigation has to be continued, but music therapy will never develop from an ancilliary treatment into a therapeutic method in its own right. However, the music therapist should be prepared if necessary to allow for useful deviations from the traditional lines of musical concepts in his efforts to reduce the state of anxiety in his patients and prevent further deterioration instinct and traditional values, thus strengthening the ethical concept.

  13. An Equation of State for Hypersaline Water in Great Salt Lake, Utah, USA

    USGS Publications Warehouse

    Naftz, D.L.; Millero, F.J.; Jones, B.F.; Green, W.R.

    2011-01-01

    Great Salt Lake (GSL) is one of the largest and most saline lakes in the world. In order to accurately model limnological processes in GSL, hydrodynamic calculations require the precise estimation of water density (??) under a variety of environmental conditions. An equation of state was developed with water samples collected from GSL to estimate density as a function of salinity and water temperature. The ?? of water samples from the south arm of GSL was measured as a function of temperature ranging from 278 to 323 degrees Kelvin (oK) and conductivity salinities ranging from 23 to 182 g L-1 using an Anton Paar density meter. These results have been used to develop the following equation of state for GSL (?? = ?? 0.32 kg m-3): ?? - ??0 = 184.01062 + 1.04708 * S - 1.21061*T + 3.14721E - 4*S2 + 0.00199T2 where ??0 is the density of pure water in kg m-3, S is conductivity salinity g L-1, and T is water temperature in degrees Kelvin. ?? 2011 U.S. Government.

  14. Coming of Age With Quantum Information

    NASA Astrophysics Data System (ADS)

    Fuchs, Christopher A.

    2011-01-01

    1. Letters to David Baker; 2. Letters to Howard Baker; 3. Letters to Howard Barnum; 4. Letters to Paul Benioff; 5. Letters to Charlie Bennett; 6. Letters to Herb Bernstein; 7. Letters to Doug Bilodeau; 8. Letters to Gilles Brassard; 9. Letters to Jeffrey Bub; 10. Letters to Carlton Caves; 11. Letters to Greg Comer; 12. Letters to Charles Enz; 13. Letters to Henry Folse; 14. Letters to Bob Griffiths; 15. Letters to Adrian Kent; 16. Letters to Rolf Landauer; 17. Letters to Hideo Mabuchi; 18. Letters to David Mermin; 19. Letters to David Meyer; 20. Letters to Jeff Nicholson; 21. Letters to Michael Nielsen; 22. Letters to Asher Peres; 23. Diary of a carefully worded paper: more letters to Asher Peres; 24. Letters to John Preskill; 25. Letters to Joseph Renes; 26. Letters to Mary Beth Ruskai; 27. Letters to Rüdiger Schack; 28. Letters to Robert Schumann; 29. Letters to Abner Shimony; 30. Letters to Jon Waskan; 31. Letters to Bill Wootters; 32. Letters to Anton Zeilinger; 33. Other letters; Index.

  15. Folding simulations for proteins with diverse topologies are accessible in days with a physics-based force field and implicit solvent.

    PubMed

    Nguyen, Hai; Maier, James; Huang, He; Perrone, Victoria; Simmerling, Carlos

    2014-10-01

    The millisecond time scale needed for molecular dynamics simulations to approach the quantitative study of protein folding is not yet routine. One approach to extend the simulation time scale is to perform long simulations on specialized and expensive supercomputers such as Anton. Ideally, however, folding simulations would be more economical while retaining reasonable accuracy, and provide feedback on structure, stability and function rapidly enough if partnered directly with experiment. Approaches to this problem typically involve varied compromises between accuracy, precision, and cost; the goal here is to address whether simple implicit solvent models have become sufficiently accurate for their weaknesses to be offset by their ability to rapidly provide much more precise conformational data as compared to explicit solvent. We demonstrate that our recently developed physics-based model performs well on this challenge, enabling accurate all-atom simulated folding for 16 of 17 proteins with a variety of sizes, secondary structure, and topologies. The simulations were carried out using the Amber software on inexpensive GPUs, providing ∼1 μs/day per GPU, and >2.5 ms data presented here. We also show that native conformations are preferred over misfolded structures for 14 of the 17 proteins. For the other 3, misfolded structures are thermodynamically preferred, suggesting opportunities for further improvement.

  16. Breaking the apple embryo dormancy by nitric oxide involves the stimulation of ethylene production.

    PubMed

    Gniazdowska, Agnieszka; Dobrzyńska, Urszula; Babańczyk, Tomasz; Bogatek, Renata

    2007-03-01

    Mature seeds of apple (Mallus domestica Borb. cv. Antonówka) are dormant and do not germinate unless their dormancy is removed by several weeks of moist-cold treatment. We investigated the effect of short-term (3 h) nitric oxide (NO) pretreatment on breaking of apple embryonic dormancy expressed as inhibition of germination and morphological abnormalities of young seedlings. Imbibition of embryos isolated from dormant apple seeds with sodium nitroprusside (SNP) or S-nitroso,N-acetyl penicillamine (SNAP) as NO donors resulted in enhanced germination. Moreover, NO treatment removed morphological abnormalities of seedlings developing from dormant embryo. The NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-teramethylimidazoline-1-oxyl-3 oxide (cPTIO) removed the above effects. NO-mediated breaking of embryonic dormancy correlated well with enhanced ethylene production. Inhibitor of ethylene synthesis (AOA) reversed the stimulatory effect of NO donors on embryo germination. Additionally SNP reduced embryo sensitivity to exogenously applied ABA ensuing dormancy breakage. We can conclude that NO acts as a regulatory factor included in the control of apple embryonic dormancy breakage by stimulation of ethylene biosynthesis.

  17. Re-Entrant Structure for Robust Superhydrophobicity and Drag Reduction

    NASA Astrophysics Data System (ADS)

    Zhao, Hong; Gad-El-Hak, Mohamed

    2014-11-01

    A re-entrant structure is required for superoleophobicity by effectively pinning low-surface-tension liquids from wetting the textures and forming a solid-liquid-air composite interface. In this work, we examine the contribution of a re-entrant structure to the robustness of superhydrophobicity and skin-friction reduction capabilities. Textured surfaces with wavy sidewall pillars provide re-entrant structures and are used as model surfaces. Gibbs energy analysis is conducted to study the pinning sites and wetting stability. The wetting robustness against pressure is characterized by breakthrough pressure, which is obtained by conservation of energy and force balance at the pinning sites. The slip length and slip velocity are evaluated through a shear stress and strain rate correlation, which is obtained using an Anton Paar rheometer. Gibbs energy analysis indicates that the breakthrough pressure provided by the wavy sidewall structure for water is about 18 times of that on the straight sidewall structure. This is mostly due to the energy barrier at the re-entrant structure. When a contact line advances onto and pins at the re-entrant structure, its slip performance degrades due to the increased no-slip fraction on the composite interface, but Cassie-Baxter state still remains.

  18. Nephrological excerpts from the Encyclopédie of Diderot and d'Alembert.

    PubMed

    De Santo, Natale Gaspare; Cirillo, Massimo; Bisaccia, Carmela; Richet, Gabriel; Eknoyan, Garabed

    2011-05-01

    The Encyclopédie of Denis Diderot (1713-1784) and Jean-Baptiste le Rond d'Alembert (1717-1783), a 35-volume work published between 1751 and 1780, is the most representative work of the Enlightenment in France. Written to explain truths based on experiment, detected by the senses, and analyzed by reason, it was meant to be an inclusive systematic dictionary of the sciences, arts, and crafts. Medicine, considered an experimental but practical science based on measurement, is not mentioned in the frontispiece, but is covered in the text based on the work of several illustrious scientists and clinicians of the period. The renal entries describe kidney structure and function, normal and pathologic urine, diabetes, anuria, polyuria, dysuria, stranguria, incontinence, kidney stones, edema, diuretics, and nephritis. The contributions of Marcello Malpighi (1628-1698), Herman Boerhaave (1668-1738), and Guichard-Joseph Duverney (1648-1730) are highlighted. Accompanying illustrations of unique perfection show the position of the kidneys according to Albrecht Haller (1708-1777); their innervation according to Raymond Vieussens (1641-1715); their structure according to Anton Nuck (1650-1692), Exupère Joseph Bertin (1712-1781), and Frederick Ruysch (1638-1731); and the genitourinary tract according to Duverney. Overall, the Encyclopédie provides a unique summary of what was known about kidney structure, function, and disease in the 18th century. PMID:21420773

  19. Densities and excess molar volumes of binary mixtures containing propylene carbonate + chlorohydrocarbons at 298.15 K and atmospheric pressure

    SciTech Connect

    Comelli, F.; Francesconi, R.

    1995-11-01

    Densities and excess molar volumes, V{sub m}{sup E}, for binary mixtures containing propylene carbonate + 10 chlorohydrocarbons (dichloromethane, 1,2-dichloroethane, 1,3-dichloropropane, 1,4-dichlorobuthane, 1,6-dichlorohexane, 1,10-dichlorodecane, 1,1,1-trichloroethane, 1,1,2,2-tetrachloroethane, trans-1,2-dichloroethene, and trichloroethene) have been measured at 298.15 K and at atmospheric pressure using an Anton Paar digital vibrating tube density meter. The results are fitted to the Redlich-Kister equation. The values of V{sub m}{sup E} for the mixtures containing dichloroalkanes show an increasing trend with the increase of the chain length and vary from a minimum of {minus}0.24 cm{sup 3}/mol for dichloromethane up to a maximum of +0.31 cm{sup 3}/mol for 1,10-dichlorodecane. The excess molar volumes for the other mixtures are negative over the entire range of composition. Results are qualitatively discussed in terms of molecular interactions.

  20. Preparation and properties of environmental-friendly coatings based on carboxymethyl cellulose nitrate ester & modified alkyd.

    PubMed

    Duan, Hongtao; Shao, Ziqiang; Zhao, Ming; Zhou, Zhenwen

    2016-02-10

    Amphipathic coating basic film-forming material carboxymethyl cellulose nitrate ester (CMCN) was synthesized and characterizations of CMCN with different ratio of functional groups were studied. Ratios of functional groups on each repeating units of CMCN have great importance in the decision of CMCN properties using as an amphipathic coating basic film-forming material and ratios of functional groups were the most concerned of the study. Ratios of functional groups on each repeating units of CMCN were measured by elemental analyzer and calculated. Series of experiments were conducted using different ratios of functional groups of CMCN. Thermal properties of CMCN were measured by FT-IR and TG. Densities of CMCN powders were measured. Aqueous coatings based on CMCN/alkyd (after chemical modified by coconut oil) were prepared and morphology & rheology of CMCN hydrophilic dispersions were measured using an Anton-Paar-Strasse 20A-8054 Graz analyzer. Contact angles between films based on CMCN and deionized water were recorded. Other properties of films were measured. CMCN with the etherification of carboxymethyl groups at 0.35-0.40, nitrate ester groups at 1.96-2.19 and hydroxyl groups at 0.46-0.64 per d-glucose was considered as the best film forming material. PMID:26686109

  1. A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines.

    PubMed

    Filipiak, Wojciech; Mochalski, Pawel; Filipiak, Anna; Ager, Clemens; Cumeras, Raquel; Davis, Cristina E; Agapiou, Agapios; Unterkofler, Karl; Troppmair, Jakob

    2016-01-01

    Volatile organic compounds (VOCs) offer unique insights into ongoing biochemical processes in healthy and diseased humans. Yet, their diagnostic use is hampered by the limited understanding of their biochemical or cellular origin and their frequently unclear link to the underlying diseases. Major advancements are expected from the analyses of human primary cells, cell lines and cultures of microorganisms. In this review, a database of 125 reliably identified VOCs previously reported for human healthy and diseased cells was assembled and their potential origin is discussed. The majority of them have also been observed in studies with other human matrices (breath, urine, saliva, feces, blood, skin emanations). Moreover, continuing improvements of qualitative and quantitative analyses, based on the recommendations of the ISO-11843 guidelines, are suggested for the necessary standardization of analytical procedures and better comparability of results. The data provided contribute to arriving at a more complete human volatilome and suggest potential volatile biomarkers for future validation. Dedication:This review is dedicated to the memory of Prof. Dr. Anton Amann, who sadly passed away on January 6, 2015. He was motivator and motor for the field of breath research. PMID:27160536

  2. “Colossal” Breakthrough: The Callosal Puncture as a Precursor to Third Ventriculostomy

    PubMed Central

    Chesler, D. A.; Pendleton, C.; Jallo, G. I.; Quiñones-Hinojosa, A.

    2015-01-01

    Background In 1908, Anton and von Bramann proposed the Balkenstich method, a corpus callosum puncture which created a communication between the ventricle and subarachnoid space. This method offered the benefit of providing continuous CSF diversion without the implantation of cannula or other shunting devices, yet it received only slight reference in the literature of the time. It remained a novel and perhaps underutilized approach at the time Cushing began expanding his neurosurgical practice at the Johns Hopkins Hospital. Materials and Methods Following IRB approval, and through the courtesy of the Alan Mason Chesney Archives, the surgical records of the Johns Hopkins Hospital for the period 1896–1912 were reviewed. Patients operated upon by Harvey Cushing were selected. Results 7 patients underwent puncture of the corpus callosum for treatment of hydrocephalus. 6 patients were treated for obstructive hydrocephalus secondary to presumed intracranial lesions. 1 patient was treated for congenital hydrocephalus. Conclusion The series reported here documents Cushing’s early use of the corpus callosum puncture to divert CSF in patients with obstructive hydrocephalus secondary to intracranial tumors, as well as an attempt to use the procedure in a pediatric patient with congenital hydrocephalus. Notably, 3 patients developed new onset left-sided weakness post-operatively, possibly due to retraction injury upon the supplementary motor intra-operative manipulations. PMID:22278787

  3. The astrological roots of mesmerism.

    PubMed

    Schaffer, Simon

    2010-06-01

    Franz Anton Mesmer's 1766 thesis on the influence of the planets on the human body, in which he first publicly presented his account of the harmonic forces at work in the microcosm, was substantially copied from the London physician Richard Mead's early eighteenth century tract on solar and lunar effects on the body. The relation between the two texts poses intriguing problems for the historiography of medical astrology: Mesmer's use of Mead has been taken as a sign of the Vienna physician's enlightened modernity while Mead's use of astro-meteorology has been seen as evidence of the survival of antiquated astral medicine in the eighteenth century. Two aspects of this problem are discussed. First, French critics of mesmerism in the 1780s found precedents for animal magnetism in the work of Paracelsus, Fludd and other early modern writers; in so doing, they began to develop a sophisticated history for astrology and astro-meteorology. Second, the close relations between astro-meteorology and Mead's project illustrate how the environmental medical programmes emerged. The making of a history for astrology accompanied the construction of various models of the relation between occult knowledge and its contexts in the enlightenment. PMID:20513627

  4. Sperm parameters: paradigmatic index of good health and longevity.

    PubMed

    Omu, Alexander E

    2013-01-01

    Since the discovery of spermatozoon by Anton van Leeuwenhoek in 1677, there has been an ever increasing understanding of its role in reproduction. Many factors adversely affect sperm quality, including varicocele, accessory gland infection, immunological factors, congenital abnormalities, and iatrogenic systemic and endocrine causes, such as diabetes mellitus, obesity, metabolic syndrome, and smoking. The mechanisms responsible for the association between poor sperm parameters and ill health may include oxidative stress, low-grade inflammation, low testosterone, and low sex-hormone-binding globulin. Oxidative stress in the testicular microenvironment may result in decreased spermatogenesis and sperm DNA damage, loss of sperm motility, and abnormal sperm morphology. Low testosterone caused by advanced age, visceral obesity, and inflammation is associated with the development of cardiovascular disease. Hence, semen analysis has an important role in the routine evaluation of idiopathic male infertility, usually manifested as low sperm counts, impaired sperm motility, or absence of sperm, and remains the most common single diagnostic tool. Several studies have shown an inverse relationship between semen quality and medical disorders. This review elucidates the effect of medical disorders and social habits on sperm quality, the mechanisms that are involved in the impairment of sperm quality, and whether or not sperm quality can be used as an index of good health and longevity in a man.

  5. Microwave Irradiation on Halloysite-Polypropylene Nanocomposites

    NASA Astrophysics Data System (ADS)

    Espino, Omar; Yust, Brian; Chipara, Dorina; Ajayan, Pullickel; Chipara, Alin; Chipara, Mircea; Utrgv Collaboration; Rice Collaboration

    Halloysite is an unique cyllindrical nanoclay characterized by poor electrical and thermal conductivity, which may become the filler of choice for the reinforcement of polymeric matrix, where electrical or thermal insulation are required. The main limits in the use of halloysite as replacement for carbon nanotube (CNT) are: 1. Smaller aspect ratio as halloysites are typically shorter than CNTs. 2. Smaller Young modulus of halloysites compared with CNTs. 3. Reduced thermal stability due to the loss of water upon heating. A research on halloysite dispersed within isotactic polypropylene is reported. To improve the interface between the halloysite and the polymeric matrix a microwave irradiation step has been considered. The local heating of the halloysite nanotubes is mediated by the absorbed/structural water content of the nanoclay. Nanocomposites loaded by various amounts of halloysite ranging from 0 % to 20 % wt. have been prepared by melt mixing by using a Haake RheoMixer. The as obtained nanocomposites have been subjected to microwave irradiation at 75 W in an Anton Paar Monowave 300 system and various irradiation times ranging from 5, 10, 15, 30, 45, and 60 minutes. The effect of microwave irradiation has been studied by Raman and FTIR spectroscopy

  6. Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex.

    PubMed

    Raveh, Barak; Karp, Jerome M; Sparks, Samuel; Dutta, Kaushik; Rout, Michael P; Sali, Andrej; Cowburn, David

    2016-05-01

    Nucleocytoplasmic transport is mediated by the interaction of transport factors (TFs) with disordered phenylalanine-glycine (FG) repeats that fill the central channel of the nuclear pore complex (NPC). However, the mechanism by which TFs rapidly diffuse through multiple FG repeats without compromising NPC selectivity is not yet fully understood. In this study, we build on our recent NMR investigations showing that FG repeats are highly dynamic, flexible, and rapidly exchanging among TF interaction sites. We use unbiased long timescale all-atom simulations on the Anton supercomputer, combined with extensive enhanced sampling simulations and NMR experiments, to characterize the thermodynamic and kinetic properties of FG repeats and their interaction with a model transport factor. Both the simulations and experimental data indicate that FG repeats are highly dynamic random coils, lack intrachain interactions, and exhibit significant entropically driven resistance to spatial confinement. We show that the FG motifs reversibly slide in and out of multiple TF interaction sites, transitioning rapidly between a strongly interacting state and a weakly interacting state, rather than undergoing a much slower transition between strongly interacting and completely noninteracting (unbound) states. In the weakly interacting state, FG motifs can be more easily displaced by other competing FG motifs, providing a simple mechanism for rapid exchange of TF/FG motif contacts during transport. This slide-and-exchange mechanism highlights the direct role of the disorder within FG repeats in nucleocytoplasmic transport, and resolves the apparent conflict between the selectivity and speed of transport. PMID:27091992

  7. Doctors in Court, Honour, and Professional Ethics: Two Scandals in Imperial Germany*

    PubMed Central

    Maehle, Andreas-Holger

    2013-01-01

    Summary Comparing two public medical affairs which involved disciplinary proceedings and libel actions, one from Bavaria and one from Prussia, this article analyzes the dynamics behind legal conflicts over doctors’ professional ethics in Imperial Germany. In both the case of Dr Maurice Hutzler, who committed suicide after conflicts with senior colleagues at the Gisela Children’s Hospital and a sentence of the court of honour of the Munich Medical District Society, and the Berlin ‘patient trade’ affair, in which the medical professors Ernst von Leyden, Hermann Senator, Karl Anton Ewald and Carl Posner were accused of having made payments to middlemen for bringing them lucrative private patients, notions of personal and professional honour played a central role. The Munich case highlighted shortcomings of the Bavarian medical court of honour system, which was less developed than its Prussian counterpart. The analysis of the two cases suggests that the ethics of medical practice in early twentieth-century Germany should be viewed as part of a culture of honour. PMID:22303773

  8. [Oswald Schwarz: a pioneer in psychosomatic urology and sexual medicine].

    PubMed

    Berberich, H J; Schultheiss, D; Kieser, B

    2015-01-01

    Oswald Schwarz, a urologist from Vienna, was a scholar of Anton Ritter von Frisch and Hans Rubritius. As a physician during World War I, he was confronted with numerous bullet wounds to the spinal cord. In 1919, he completed his professorial thesis"Bladder dysfunction as a result of bullet wounds to the spinal cord". Oswald Schwarz was known as a committed surgeon. As an urologist he also treated patients with sexual dysfunction. Besides his practical and scientific urology-related work, he was also interested in psychology and philosophy. He held lectures on both subjects earning himself the nickname, the Urosoph. In the 1920s, Oswald Schwarz belonged to the inner circle of Alfred Adler, the founder of Individual Psychology, and was editor of the first psychosomatic textbook published in German, "Psychological origin and psychotherapy of physical symptoms" (1925). In addition, Schwarz wrote numerous articles and several books on sexual medicine. He also made many valuable contributions to the development of medical anthropology. Altogether, his work includes over 130 publications. Faced with the rise of fascism and National Socialism in Europe, Oswald Schwarz, who was of Jewish origin, emigrated to England in 1934. There he died in 1949. Unfortunately his scientific work has largely been forgotten. The aim of the following article is to remind us of his important contributions to the field.

  9. Reciprocal Crossovers and a Positional Preference for Strand Exchange in Recombination Events Resulting in Deletion or Duplication of Chromosome 17p11.2

    PubMed Central

    Bi, Weimin; Park, Sung-Sup; Shaw, Christine J.; Withers, Marjorie A.; Patel, Pragna I.; Lupski, James R.

    2003-01-01

    Smith-Magenis syndrome (SMS) is caused by an ∼4-Mb heterozygous interstitial deletion on chromosome 17p11.2 in ∼80%–90% of affected patients. Three large (∼200 kb), complex, and highly homologous (∼98%) low-copy repeats (LCRs) are located inside or flanking the SMS common deletion. These repeats, also known as “SMS-REPs,” are termed “distal,” “middle,” and “proximal.” The directly oriented distal and proximal copies act as substrates for nonallelic homologous recombination resulting in both the deletion associated with SMS and the reciprocal duplication: dup(17)(p11.2p11.2). Using restriction enzyme cis-morphism analyses and direct sequencing, we mapped the regions of strand exchange in 16 somatic-cell hybrids that harbor only the recombinant SMS-REP. Our studies showed that the sites of crossovers were distributed throughout the region of homology between the distal and proximal SMS-REPs. However, despite ∼170 kb of high homology, 50% of the recombinant junctions occurred in a 12.0-kb region within the KER gene clusters. DNA sequencing of this hotspot (positional preference for strand exchange) in seven recombinant SMS-REPs narrowed the crossovers to an ∼8-kb interval. Four of them occurred in a 1,655-bp region rich in polymorphic nucleotides that could potentially reflect frequent gene conversion. For further evaluation of the strand exchange frequency in patients with SMS, novel junction fragments from the recombinant SMS-REPs were identified. As predicted by the reciprocal-recombination model, junction fragments were also identified from this hotspot region in patients with dup(17)(p11.2p11.2), documenting reciprocity of the positional preference for strand exchange. Several potential cis-acting recombination-promoting sequences were identified within the hotspot. It is interesting that we found 2.1-kb AT-rich inverted repeats flanking the proximal and middle KER gene clusters but not the distal one. The role of any or all of these

  10. Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence.

    PubMed

    Becker, Richard A; Ankley, Gerald T; Edwards, Stephen W; Kennedy, Sean W; Linkov, Igor; Meek, Bette; Sachana, Magdalini; Segner, Helmut; Van Der Burg, Bart; Villeneuve, Daniel L; Watanabe, Haruna; Barton-Maclaren, Tara S

    2015-08-01

    Systematic consideration of scientific support is a critical element in developing and, ultimately, using adverse outcome pathways (AOPs) for various regulatory applications. Though weight of evidence (WoE) analysis has been proposed as a basis for assessment of the maturity and level of confidence in an AOP, methodologies and tools are still being formalized. The Organization for Economic Co-operation and Development (OECD) Users' Handbook Supplement to the Guidance Document for Developing and Assessing AOPs (OECD 2014a; hereafter referred to as the OECD AOP Handbook) provides tailored Bradford-Hill (BH) considerations for systematic assessment of confidence in a given AOP. These considerations include (1) biological plausibility and (2) empirical support (dose-response, temporality, and incidence) for Key Event Relationships (KERs), and (3) essentiality of key events (KEs). Here, we test the application of these tailored BH considerations and the guidance outlined in the OECD AOP Handbook using a number of case examples to increase experience in more transparently documenting rationales for assigned levels of confidence to KEs and KERs, and to promote consistency in evaluation within and across AOPs. The major lessons learned from experience are documented, and taken together with the case examples, should contribute to better common understanding of the nature and form of documentation required to increase confidence in the application of AOPs for specific uses. Based on the tailored BH considerations and defining questions, a prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described. The applicability of the approach is also demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish. Following the acquisition of additional experience in the development and assessment of AOPs, further refinement of parameterization of the model through expert

  11. Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence.

    PubMed

    Becker, Richard A; Ankley, Gerald T; Edwards, Stephen W; Kennedy, Sean W; Linkov, Igor; Meek, Bette; Sachana, Magdalini; Segner, Helmut; Van Der Burg, Bart; Villeneuve, Daniel L; Watanabe, Haruna; Barton-Maclaren, Tara S

    2015-08-01

    Systematic consideration of scientific support is a critical element in developing and, ultimately, using adverse outcome pathways (AOPs) for various regulatory applications. Though weight of evidence (WoE) analysis has been proposed as a basis for assessment of the maturity and level of confidence in an AOP, methodologies and tools are still being formalized. The Organization for Economic Co-operation and Development (OECD) Users' Handbook Supplement to the Guidance Document for Developing and Assessing AOPs (OECD 2014a; hereafter referred to as the OECD AOP Handbook) provides tailored Bradford-Hill (BH) considerations for systematic assessment of confidence in a given AOP. These considerations include (1) biological plausibility and (2) empirical support (dose-response, temporality, and incidence) for Key Event Relationships (KERs), and (3) essentiality of key events (KEs). Here, we test the application of these tailored BH considerations and the guidance outlined in the OECD AOP Handbook using a number of case examples to increase experience in more transparently documenting rationales for assigned levels of confidence to KEs and KERs, and to promote consistency in evaluation within and across AOPs. The major lessons learned from experience are documented, and taken together with the case examples, should contribute to better common understanding of the nature and form of documentation required to increase confidence in the application of AOPs for specific uses. Based on the tailored BH considerations and defining questions, a prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described. The applicability of the approach is also demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish. Following the acquisition of additional experience in the development and assessment of AOPs, further refinement of parameterization of the model through expert

  12. Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats.

    PubMed

    Xu, Meijuan; Wang, Guangji; Xie, Haitang; Huang, Qing; Wang, Wei; Jia, Yuanwei

    2008-02-12

    Sheng-Mai-San (SMS) is a famous traditional Chinese medicine (TCM) recipe, containing Radix Ginseng (Panax ginseng C.A. Mey., Araliaceae), Radix Ophiopogonis (Ophiopogon japonicus (Thunb.) Ker-Gawl., Liliaceae) and Fructus Schisandrae (Schisandra chinensis (Turcz.) Baill., Magnoliaceae), and has been used more than one thousand years. In this research, pharmacokinetics of one component of this TCM recipe was studied. Schizandrin is the main absorbed effective ingredient of Fructus Schisandrae and its pharmacokinetics were studied following oral administration of pure schizandrin, Fructus Schisandrae aqueous extract, and SMS decoction in rats with approximately the same dose of 5mg/kg. At different time points (0, 0.083, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10 and 12h) after administration, the concentrations of schizandrin in rat plasma were determined by LC-MS, and main pharmacokinetic parameters were estimated. It was found that both AUC0-tn and T1/2 of schizandrin in Fructus Schisandrae aqueous extract and in SMS decoction were increased significantly (p<0.05) comparing with that in monomer. The content assay also revealed that the concentrations of lignans would increase when SMS decocting, comparing with Fructus Schisandrae. These results indicate that some ingredients in SMS may increase the dissolution of schizandrin when decocting in vitro, and delay its elimination and enhance its bioavailability in rat.

  13. A novel keratinase from Bacillus tequilensis strain Q7 with promising potential for the leather bating process.

    PubMed

    Zaraî Jaouadi, Nadia; Rekik, Hatem; Ben Elhoul, Mouna; Zohra Rahem, Fatma; Hila, Chiraz Gorgi; Ben Aicha, Houda Slimene; Badis, Abdelmalek; Toumi, Abdessatar; Bejar, Samir; Jaouadi, Bassem

    2015-08-01

    The present paper reports on the purification and characterization of an extracellular keratinase (KERQ7) newly purified from Bacillus tequilensis Q7. Pure protein was obtained after ammonium sulfate fractionation (30-60%), followed by Mono S Sepharose cation-exchange chromatography. MALDI-TOF/MS analysis revealed that the purified enzyme was a monomer with a molecular mass of 28,355.07-Da. The sequence of the 21 N-terminal residues of KERQ7 showed high homology with those of Bacillus keratinases. Optimal activity was achieved at pH 7 and 30°C. KERQ7 was completely inhibited by PMSF and DFP, which suggests that it belongs to the serine keratinase family. KERQ7 displayed higher levels of hydrolysis and catalytic efficiency than Basozym(®) CS 10, Koropon(®) SC 5K, and Pyrase(®) 250 MP. The kerQ7 gene encoding KERQ7 was cloned, sequenced, and expressed in Escherichia coli BL21(DE3)pLysS. The biochemical properties of the extracellular purified recombinant enzyme (rKERQ7) were similar to those of native KERQ7. The deduced amino acid sequence showed strong homology with other Bacillus keratinases. The highest sequence identity value (97%) was obtained with KERUS from Brevibacillus brevis US575, with only 7 aa of difference. These properties make KERQ7 a potential promising and eco-friendly enzymatically enhanced process for animal hide bating in the leather processing industry.

  14. Anopheles (Kerteszia) cruzii (DIPTERA: CULICIDAE) IN PERIDOMICILIARY AREA DURING ASYMPTOMATIC MALARIA TRANSMISSION IN THE ATLANTIC FOREST: MOLECULAR IDENTIFICATION OF BLOOD-MEAL SOURCES INDICATES HUMANS AS PRIMARY INTERMEDIATE HOSTS

    PubMed Central

    Kirchgatter, Karin; Tubaki, Rosa Maria; Malafronte, Rosely dos Santos; Alves, Isabel Cristina; Lima, Giselle Fernandes Maciel de Castro; Guimarães, Lilian de Oliveira; Zampaulo, Robson de Almeida; Wunderlich, Gerhard

    2014-01-01

    Anopheles (Kerteszia) cruzii has been implicated as the primary vector of human and simian malarias out of the Brazilian Amazon and specifically in the Atlantic Forest regions. The presence of asymptomatic human cases, parasite-positive wild monkeys and the similarity between the parasites infecting them support the discussion whether these infections can be considered as a zoonosis. Although many aspects of the biology of An. cruzii have already been addressed, studies conducted during outbreaks of malaria transmission, aiming at the analysis of blood feeding and infectivity, are missing in the Atlantic Forest. This study was conducted in the location of Palestina, Juquitiba, where annually the majority of autochthonous human cases are notified in the Atlantic Forest of the state of São Paulo. Peridomiciliary sites were selected for collection of mosquitoes in a perimeter of up to 100 m around the residences of human malaria cases. The mosquitoes were analyzed with the purpose of molecular identification of blood-meal sources and to examine the prevalence of Plasmodium. A total of 13,441 females of An. (Ker.) cruzii were collected. The minimum infection rate was calculated at 0.03% and 0.01%, respectively, for P. vivax and P. malariae and only human blood was detected in the blood-fed mosquitoes analyzed. This data reinforce the hypothesis that asymptomatic human carriers are the main source of anopheline infection in the peridomiciliary area, making the probability of zoonotic transmission less likely to happen. PMID:25229220

  15. Development of transgenic sweet potato with multiple virus resistance in South Africa (SA).

    PubMed

    Sivparsad, B J; Gubba, A

    2014-04-01

    Multiple infections of Sweet potato feathery mottle virus (SPFMV), Sweet potato chlorotic stunt virus (SPCSV), Sweet potato virus G (SPVG) and Sweet potato mild mottle virus (SPMMV) cause a devastating synergistic disease complex of sweet potato (Ipomoea batatas Lam.) in KwaZulu-Natal, South Africa. In order to address the problem of multiple virus infections and synergism, this study aimed to develop transgenic sweet potato (cv. Blesbok) plants with broad virus resistance. Coat protein gene segments of SPFMV, SPCSV, SPVG and SPMMV were used to induce gene silencing in transgenic sweet potato. Transformation of apical tips of sweet potato cv. Blesbok was achieved by using Agrobacterium tumefaciens strain LBA4404 harboring the expression cassette. Polymerase chain reaction and Southern blot analyses showed integration of the transgenes occurred in six of the 24 putative transgenic plants and that all plants seemed to correspond to the same transformation event. The six transgenic plants were challenged by graft inoculation with SPFMV, SPCSV, SPVG and SPMMV-infected Ipomoea setosa Ker. Although virus presence was detected using nitrocellulose enzyme-linked immunosorbent assay, all transgenic plants displayed delayed and milder symptoms of chlorosis and mottling of lower leaves when compared to the untransformed control plants. These results warrant further investigation on resistance to virus infection under field conditions.

  16. Far infrared spectrum of Methanol-D2 in the lowest torsional state (e0)

    NASA Astrophysics Data System (ADS)

    Mukhopadhyay, Indra

    2016-03-01

    The infrared (IR) and far infrared (FIR) absorption spectra have been measured for the Methanol-D1 and D2 species in the wave number range of 20-1200 cm-1 at the Justus Liebig Universität in Giessen, Germany using a Brüker Fourier Transform spectrometer at a resolution of 0.002 cm-1. The spectra looked very complicated but analyses were possible for the lower lying states. At higher wave number regions spectra of few vibrational fundamental modes were visible. In this communication, the details of the assignments and analyses of the lowest lying internal rotational state (e0) for Methanol-D2 are reported. A catalog of about 900 assigned spectral lines has been prepared and is made available from the author to conserve space. As application of this work, it was possible to assign some optically pumped FIR laser lines to quantum states. The results should be useful for "radio astronomers" and in the field of optically pumped FIR and Sub-millimeter Wave (SMMW) lasers which are used in Tokamaks for plasma diagnostics and as local oscillators in radio detection from space.

  17. The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study.

    PubMed

    Chang, Ching-Mao; Chu, Hsueh-Ting; Wei, Yau-Huei; Chen, Fang-Pey; Wang, Shengwen; Wu, Po-Chang; Yen, Hung-Rong; Chen, Tzeng-Ji; Chang, Hen-Hong

    2015-01-01

    This large-scale survey aimed to evaluate frequencies and patterns of Chinese herbal medicine (CHM) used for Sjögren's syndrome (SS) in Taiwan by analyzing the National Health Insurance Research Database (NHIRD) for cases in which CHM was used as an alternative therapy to Western medicine for improving patients' discomforts. We analyzed cases of SS principal diagnosis (ICD-9:710.2) with a catastrophic illness certificate (CIC) in traditional Chinese medicine (TCM) outpatient clinics from three cohorts of the Longitudinal Health Insurance Database (LHID) in the NHIRD between 2002 and 2011. CHM prescription patterns for SS were evaluated from claimed visitation files and corresponding prescription files. There were 15,914 SS patients with CIC (SS/CIC), and we found only 130 SS/CIC cases visiting TCM clinics in LHID2000, 133 in LHID2005, and 126 in LHID2010. After removing duplicate data, 366 SS/CIC and 4,867 visits were analyzed. The 50-59 year age group showed the highest ratio (29.51%) in both women and men. "Qi-Ju-Di-Huang-Wan" and "Xuan-Shen" (Scrophularia ningpoensis Hemsl.) was the most commonly used formula and single herb, respectively. "Qi-Ju-Di-Huang-Wan, Gan-Lu-Yin, Xuan-Shen, Mai-Men-Dong (Ophiopogon japonicus (L. f.) Ker-Gawl.), and Sheng-Di-Huang (raw Rehmannia glutinosa Libosch)" were the core pattern prescriptions in treating SS/CIC. PMID:25923413

  18. Decomposition of nitroimidazole ions: experiment and theory.

    PubMed

    Feketeová, Linda; Postler, Johannes; Zavras, Athanasios; Scheier, Paul; Denifl, Stephan; O'Hair, Richard A J

    2015-05-21

    Nitroimidazoles are important compounds with chemotherapeutic applications as antibacterial drugs or as radiosensitizers in radiotherapy. Despite their use in biological applications, little is known about the fundamental properties of these compounds. Understanding the ionization reactions of these compounds is crucial in evaluating the radiosensitization potential and in developing new and more effective drugs. Thus, the present study investigates the decomposition of negative and positive ions of 2-nitroimidazole and 4(5)-nitroimidazole using low- and high-energy Collision-Induced Dissociation (CID) and Electron-Induced Dissociation (EID) by two different mass spectrometry techniques and is supported by quantum chemistry calculations. EID of [M+H](+) leads to more extensive fragmentation than CID and involves many radical cleavages including loss of H˙ leading to the formation of the radical cation, M˙(+). The stability (metastable decay) and the fragmentation (high-energy CID) of the radical cation M˙(+) have been probed in a crossed-beam experiment involving primary electron ionization of the neutral nitroimidazole. Thus, fragments in the EID spectra of [M+H](+) that come from further dissociation of radical cation M˙(+) have been highlighted. The loss of NO˙ radical from M˙(+) is associated with a high Kinetic Energy Release (KER) of 0.98 eV. EID of [M-H](-) also leads to additional fragments compared to CID, however, with much lower cross section. Only EID of [M+H](+) leads to a slight difference in the decomposition of 2-nitroimidazole and 4(5)-nitroimidazole.

  19. A model for the stability and creep of organic materials.

    PubMed

    Jäger, Ingomar L

    2005-07-01

    A model is presented for the thermally assisted breaking of a number of bonds arranged in parallel and stressed by an individual soft spring each. Using a simplified potential for the bond it is shown that in equilibrium there are two definite regions of elastic behavior: one with all bonds intact, the other with a variable fraction of bonds broken, therefore with a tangent modulus steadily decreasing with applied stress. Criteria are given for the existence of these regions. Beyond these regions time-dependent creep to rupture is found, limited, in turn, by the theoretical fracture strength, the stress necessary for fracture without any thermal assistance, beyond which a bound state is impossible. The time-to-fracture for creep rupture is calculated and an example of the time evolution of the accelerating creep given. The results of the calculations are applied to experimental data on Wallaby tendons by Wang and Ker (J. Exp. Biol. 198 (1995) 831) and data estimated for the bond potential depth, the theoretical fracture strength and the number density of bonds involved as well as the elastic modulus of the ensemble. Values are derived under the assumption of one deformation mechanism being dominant--e.g., (sub-)fibril sliding or sliding of collagen molecules along one another--but the model cannot definitely distinguish between mechanisms. PMID:15922757

  20. Anopheles (Kerteszia) lepidotus (Diptera: Culicidae), not the malaria vector we thought it was: Revised male and female morphology; larva, pupa, and male genitalia characters; and molecular verification

    PubMed Central

    HARRISON, BRUCE A.; RUIZ-LOPEZ, FREDDY; FALERO, GUILLERMO CALDERON; SAVAGE, HARRY M.; PECOR, JAMES E.; WILKERSON, RICHARD C.

    2015-01-01

    The name Anopheles (Kerteszia) lepidotus Zavortink, commonly used for an important malaria vector in the eastern cordillera of the Andes, is here corrected to An. pholidotus Zavortink. We discovered that An. (Ker.) specimens from Peru, and reared-associated specimens from Ecuador, had unambiguous habitus characters that matched those on the male holotype of An. lepidotus. However, the specimens do not exhibit characters of the female allotype and female paratypes of An. lepidotus, which are actually An. pholidotus. Our specimens are the first correctly associated females of An. lepidotus, which allow us to provide a new morphological interpretation for the adult habitus of this species. This finding is also corroborated by molecular data from a portion of the Cytochrome Oxidase I (COI) gene and ribosomal DNA Internal Transcribed Spacer 2 (rDNA ITS2). The pupal stage of An. lepidotus is described for the first time, and additional larval characters are also noted. Diagnostic morphological characters for the adult, pupal, and larval stages of An. pholidotus are provided to separate the two species. All stages of An. lepidotus are easily separated from other currently known species in subgenus Kerteszia and a new key to the females of An. (Kerteszia) is given. Previously published distribution, bionomics, and medical significance data are corrected and enhanced. PMID:26726290

  1. ETHNOGRAPHY OF THE DRUG SAFED – MUSALI IN INDIA : A REVIEW

    PubMed Central

    Patil, D.A.

    2001-01-01

    The drug safed-musali’ has always remained the subject of dispute and object of investigations. This paper evaluates comparatively its ethnomedicinal records as also those found in literature on the modern usage in Indian context alongwith the observations of the present author. The safedmusali belongs to the various species of two different well known liliaceous genera viz., Asparagus L. and Chlorophytum Ker-Gowl., and a least known orchidaceous genus Pachystoma Bl. It appears that the wide modern usage of safed-musali might have sprung from its ethnomedicinal leads in our country. The plant sources of its procurement although varied should be regarded only as surrogates for each other. The drug itself is a substitute for ‘Salep’ or ‘Salep-misri’. In the light of present investigation, it is surveyed, reviewed and highlighted pertinently. The attempts to cultivate different species which are implicated as safed-musali need a fillip for the betterment of tribal people and Indian societies at large. PMID:22557034

  2. Resistive wall mode feedback control in EXTRAP T2R with improved steady-state error and transient response

    NASA Astrophysics Data System (ADS)

    Brunsell, P. R.; Olofsson, K. E. J.; Frassinetti, L.; Drake, J. R.

    2007-10-01

    Experiments in the EXTRAP T2R reversed field pinch [P. R. Brunsell, H. Bergsåker, M. Cecconello et al., Plasma Phys. Control. Fusion 43, 1457 (2001)] on feedback control of m =1 resistive wall modes (RWMs) are compared with simulations using the cylindrical linear magnetohydrodynamic model, including the dynamics of the active coils and power amplifiers. Stabilization of the main RWMs (n=-11,-10,-9,-8,+5,+6) is shown using modest loop gains of the order G ˜1. However, other marginally unstable RWMs (n=-2,-1,+1,+2) driven by external field errors are only partially canceled at these gains. The experimental system stability limit is confirmed by simulations showing that the latency of the digital controller ˜50μs is degrading the system gain margin. The transient response is improved with a proportional-plus-derivative controller, and steady-state error is improved with a proportional-plus-integral controller. Suppression of all modes is obtained at high gain G ˜10 using a proportional-plus-integral-plus-derivative controller.

  3. The epithelial-mesenchymal transition induced by keratinocyte growth conditions is overcome by E6 and E7 from HPV16, but not HPV8 and HPV38: Characterization of global transcription profiles

    SciTech Connect

    Azzimonti, Barbara; Dell'Oste, Valentina; Borgogna, Cinzia; Mondini, Michele; Gugliesi, Francesca; De Andrea, Marco; Chiorino, Giovanna; Scatolini, Maria; Ghimenti, Chiara; Landolfo, Santo; Gariglio, Marisa

    2009-06-05

    The aim of this study was to evaluate the growth properties of primary human keratinocytes expressing E6 and E7 proteins, which are from either the beta- or alpha-genotypes, under different culture conditions. We demonstrated that keratinocytes expressing E6 and E7, from both HPV8 and 38, irreversibly underwent the epithelial-mesenchymal transition (EMT) when grown on plastic with FAD medium (F12/DMEM/5%FBS). Expression of E6/E7 from HPV16 was capable of fully overcoming the FAD-induced EMT. Immortalization was only observed in HPV16-transduced cell lines, while the more proliferating phenotype of both KerHPV8 and 38 was mainly related to FAD-induced EMT. Microarray analysis of exponentially growing cells identified 146 cellular genes that were differentially regulated in HPV16 compared to HPV8- and 38-transduced cells. A large accumulation of transcripts associated with epidermal development and differentiation was observed in HPV16-transduced cells, whereas transcripts of genes involved in the extracellular matrix, multicellular organismal processes, and inflammatory response were affected in HPV8 and 38-transduced cells.

  4. Attosecond time delays in the nuclear dynamics of strong-field molecular dissociation

    NASA Astrophysics Data System (ADS)

    Armstrong, Greg; Ultrafast Molecular Physics Group Collaboration

    2016-05-01

    The relative time delay in the photoemission from neighboring atomic valence sub-shells has become an area of considerable recent interest, with delays of tens of attoseconds reported in pump-probe experiments for a number of atomic targets. Such delays may be extracted, for example, from phase differences in the photoelectron energy spectra for the different sub-shells as a function of delay between pump and probe pulses. The focus of such experiments has, to date, been atomic targets, on the assumption that only electronic motion can lead to delays on the attosecond scale.We investigate the molecular analogue of such studies by calculating the kinetic-energy release (KER) spectrum for neighboring vibrational states as a function of pump-probe delay time. In particular, we focus on molecular targets where electronic excitation is negligible, and show that attosecond time delays are also possible for purely nuclear motion. We will present evidence of these attosecond delays derived from both numerical solutions of the time-dependent Schrödinger equation and experiment. We analyze and understand the observed shifts using the photon-phase formalism. G.S.J. Armstrong, J. McKenna, B. Gaire, M. Zohrabi, B. Berry, B. Jochim, Kanaka Raju, P., P. Feizollah, K.D. Carnes, Ben-Itzhak, B.D. Esry.

  5. Orientation dependence of the ionization of CO and NO in an intense femtosecond two-color laser field

    NASA Astrophysics Data System (ADS)

    Li, Hui; Ray, Dipanwita; de, Sankar; Cao, Wei; Laurent, Guillaume; Wang, Zhenhua; Thu Le, Anh; Cocke, C. Lewis; Znakovskaya, Irina; Kling, Matthias

    2012-06-01

    Two-color (800 nm and 400 nm) ultrashort (30±10 fs) laser pulses were used to ionize and dissociate CO and NO. The emission of C^+q, N^+q and O^+ fragments were measured with a velocity-map-imaging (VMI) system. The data show that the ionization rate is dependent on the orientation of the molecules with respect to the laser polarization. Both molecules ionize more easily when the electric field points from C to O in CO and from N to O in NO. The asymmetry of emission is much higher for CO than for NO. The sign of the asymmetry is not strongly dependent on kinetic energy release (KER). The favored ionization orientation is in agreement with the expectation of the molecular orbital Ammosov-Delone-Krainov (MO-ADK) [1] theory and with a Stark-corrected version of a strong-field-approximation (SFA) calculation [2]. [4pt] [1] X.M. Tong, et al., Phys. Rev. A 66, 033402 (2002).[0pt] [2] H. Li, et al., Phys. Rev. A 84, 043429 (2011).

  6. The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study.

    PubMed

    Chang, Ching-Mao; Chu, Hsueh-Ting; Wei, Yau-Huei; Chen, Fang-Pey; Wang, Shengwen; Wu, Po-Chang; Yen, Hung-Rong; Chen, Tzeng-Ji; Chang, Hen-Hong

    2015-01-01

    This large-scale survey aimed to evaluate frequencies and patterns of Chinese herbal medicine (CHM) used for Sjögren's syndrome (SS) in Taiwan by analyzing the National Health Insurance Research Database (NHIRD) for cases in which CHM was used as an alternative therapy to Western medicine for improving patients' discomforts. We analyzed cases of SS principal diagnosis (ICD-9:710.2) with a catastrophic illness certificate (CIC) in traditional Chinese medicine (TCM) outpatient clinics from three cohorts of the Longitudinal Health Insurance Database (LHID) in the NHIRD between 2002 and 2011. CHM prescription patterns for SS were evaluated from claimed visitation files and corresponding prescription files. There were 15,914 SS patients with CIC (SS/CIC), and we found only 130 SS/CIC cases visiting TCM clinics in LHID2000, 133 in LHID2005, and 126 in LHID2010. After removing duplicate data, 366 SS/CIC and 4,867 visits were analyzed. The 50-59 year age group showed the highest ratio (29.51%) in both women and men. "Qi-Ju-Di-Huang-Wan" and "Xuan-Shen" (Scrophularia ningpoensis Hemsl.) was the most commonly used formula and single herb, respectively. "Qi-Ju-Di-Huang-Wan, Gan-Lu-Yin, Xuan-Shen, Mai-Men-Dong (Ophiopogon japonicus (L. f.) Ker-Gawl.), and Sheng-Di-Huang (raw Rehmannia glutinosa Libosch)" were the core pattern prescriptions in treating SS/CIC.

  7. A hardware fast tracker for the ATLAS trigger

    NASA Astrophysics Data System (ADS)

    Asbah, Nedaa

    2016-09-01

    The trigger system of the ATLAS experiment is designed to reduce the event rate from the LHC nominal bunch crossing at 40 MHz to about 1 kHz, at the design luminosity of 1034 cm-2 s-1. After a successful period of data taking from 2010 to early 2013, the LHC already started with much higher instantaneous luminosity. This will increase the load on High Level Trigger system, the second stage of the selection based on software algorithms. More sophisticated algorithms will be needed to achieve higher background rejection while maintaining good efficiency for interesting physics signals. The Fast TracKer (FTK) is part of the ATLAS trigger upgrade project. It is a hardware processor that will provide, at every Level-1 accepted event (100 kHz) and within 100 microseconds, full tracking information for tracks with momentum as low as 1 GeV. Providing fast, extensive access to tracking information, with resolution comparable to the offline reconstruction, FTK will help in precise detection of the primary and secondary vertices to ensure robust selections and improve the trigger performance. FTK exploits hardware technologies with massive parallelism, combining Associative Memory ASICs, FPGAs and high-speed communication links.

  8. Developing the concept of sustainability in nursing.

    PubMed

    Goodman, Benny

    2016-10-01

    Sustainability, and the related concept of climate change, is an emerging domain within nursing and nurse education. Climate change has been posited as a serious global health threat requiring action by health professionals and action at international level. Anåker & Elf undertook a concept analysis of sustainability in nursing based on Walker and Avant's framework. Their main conclusions seem to be that while defining attributes and cases can be established, there is not enough research into sustainability in the nursing literature. This paper seeks to develop their argument to argue that sustainability in nursing can be better understood by accessing non-nursing and grey literature and, for example, the literature in the developing web-based 'paraversity'. Without this understanding, and application in nursing scholarship, nurses will have a rather narrow understanding of sustainability and its suggested links with social and health inequalities and the dynamics underpinning unsustainable neoliberalist political economy. This understanding is based on the social and political determinants of health approach and the emerging domain of planetary health. However, this is a major challenge as it requires a critical reflection on what counts as nursing knowledge, a reflection which might reject sustainability and political economy as irrelevant to much of nursing practice.

  9. Decomposition of nitroimidazole ions: experiment and theory.

    PubMed

    Feketeová, Linda; Postler, Johannes; Zavras, Athanasios; Scheier, Paul; Denifl, Stephan; O'Hair, Richard A J

    2015-05-21

    Nitroimidazoles are important compounds with chemotherapeutic applications as antibacterial drugs or as radiosensitizers in radiotherapy. Despite their use in biological applications, little is known about the fundamental properties of these compounds. Understanding the ionization reactions of these compounds is crucial in evaluating the radiosensitization potential and in developing new and more effective drugs. Thus, the present study investigates the decomposition of negative and positive ions of 2-nitroimidazole and 4(5)-nitroimidazole using low- and high-energy Collision-Induced Dissociation (CID) and Electron-Induced Dissociation (EID) by two different mass spectrometry techniques and is supported by quantum chemistry calculations. EID of [M+H](+) leads to more extensive fragmentation than CID and involves many radical cleavages including loss of H˙ leading to the formation of the radical cation, M˙(+). The stability (metastable decay) and the fragmentation (high-energy CID) of the radical cation M˙(+) have been probed in a crossed-beam experiment involving primary electron ionization of the neutral nitroimidazole. Thus, fragments in the EID spectra of [M+H](+) that come from further dissociation of radical cation M˙(+) have been highlighted. The loss of NO˙ radical from M˙(+) is associated with a high Kinetic Energy Release (KER) of 0.98 eV. EID of [M-H](-) also leads to additional fragments compared to CID, however, with much lower cross section. Only EID of [M+H](+) leads to a slight difference in the decomposition of 2-nitroimidazole and 4(5)-nitroimidazole. PMID:25899156

  10. Theoretical investigation of the competitive mechanism between dissociation and ionization of H₂⁺ in intense field.

    PubMed

    Yao, Hongbin; Zhao, Guangjiu

    2014-10-01

    The competitive mechanism between dissociation and ionization of hydrogen molecular ion in intense field has been theoretically investigated by using an accurate non-Born-Oppenheimer method. The relative yield of fragments indicates that the dissociation and ionization channels are competitive with the increasing laser intensity from 5.0 × 10(13) to 2.0 × 10(14) W/cm(2). In the case of intensity lower than 1.0 × 10(14) W/cm(2), the dissociation channel is dominant, with a minor contribution from ionization. The mechanism of dissociation includes the contributions from the bond softening, bond hardening, below-threshold dissociation, and above-threshold dissociation, which are strongly dependent on the laser intensity and initial vibrational state. Furthermore, the ionization dominates over the dissociation channel at the highest intensity of 2.0 × 10(14) W/cm(2). The reasonable origin of ionization is ascribed as the above-threshold Coulomb explosion, which has been demonstrated by the space-time dependent ionization rate. Moreover, the competition mechanism between dissociation and ionization channels are displayed on the total kinetic energy resolved (KER) spectra, which could be tested at current experimental conditions.

  11. Developing the concept of sustainability in nursing.

    PubMed

    Goodman, Benny

    2016-10-01

    Sustainability, and the related concept of climate change, is an emerging domain within nursing and nurse education. Climate change has been posited as a serious global health threat requiring action by health professionals and action at international level. Anåker & Elf undertook a concept analysis of sustainability in nursing based on Walker and Avant's framework. Their main conclusions seem to be that while defining attributes and cases can be established, there is not enough research into sustainability in the nursing literature. This paper seeks to develop their argument to argue that sustainability in nursing can be better understood by accessing non-nursing and grey literature and, for example, the literature in the developing web-based 'paraversity'. Without this understanding, and application in nursing scholarship, nurses will have a rather narrow understanding of sustainability and its suggested links with social and health inequalities and the dynamics underpinning unsustainable neoliberalist political economy. This understanding is based on the social and political determinants of health approach and the emerging domain of planetary health. However, this is a major challenge as it requires a critical reflection on what counts as nursing knowledge, a reflection which might reject sustainability and political economy as irrelevant to much of nursing practice. PMID:27456540

  12. FOREWORD: The XXV IAHR Symposium on Hydraulic Machinery and Systems marks half a century tradition

    NASA Astrophysics Data System (ADS)

    Susan-Resiga, Romeo

    2010-05-01

    'Politehnica' of Timisoara in 1923 'It is not the walls that make a school, but the spirit living inside'. A particular trademark of the 'Politehnica' of Timisoara was the continuous effort to answer industrial problems by training the students not only on theoretical aspects but also in design and manufacturing, as well as in laboratory works. Developing modern laboratories, where students can observe and understand first hand the engineering applications along the years a priority for Timisoara 'Politehnica' University. The School of Hydraulic Machinery within the 'Politehnica' University of Timisoara was established in early 1930 by Professor Aurel Barglazan (1905-1960), and further developed by Professor Ioan Anton (born 1924), both members of the Romanian Academy. The Laboratory of Hydraulic Machines from Timisoara (LMHT) started back in 1928 in a small hut, with a test rig for Francis and Kaplan turbines manufactured by J M Voith. LMHT was continuously developed and was officially recognized in 1959 as being one of the leading research and developing laboratories in Romania. It was the foundation of the Romanian efforts of designing and manufacturing hydraulic turbines starting in 1960 at the Resita Machine Building Factory. Under the leadership of Professor Ioan Anton, the Timisoara School in Hydraulic Machinery has focused the basic and development research activities on the following main topics: (i) Turbine Hydrodynamics, (ii) Hydrofoil Cascade Hydrodynamics, (iii) Cavitation in Hydraulic Machines and Equipments, (iv) Scale-up Effects in Hydraulic Machines. With the establishment in the year 2000 of the National Center for Engineering of Systems with Complex Fluids, within the 'Politehnica' University of Timisoara, the research in turbomachinery hydrodynamics and cavitation included high performance computing for flows in hydraulic machines, as well as the development of novel technologies to mitigate the self-induced flow instabilities in hydraulic turbines operated

  13. Experiences on Altimeter Calibration at Ibiza Island and Cape of Begur (Spain)

    NASA Astrophysics Data System (ADS)

    Martinez Benjamin, J. J.; Martinez Harcia, M.; Ortiz Castello, M. A.; Talaya, J.; Baron, A.; Rodriguez Velasco, G.; Martín Davila, J.; Garate, J.; Bonnefond, P.; Garcia, C.

    2006-07-01

    Three preliminary camp aigns for TOPEX /POSEIDON (T/P) wer e made in March 1999 and July 2000 and for JASON-1 in August 2002, in the NW Mediterran ean Sea at th e Begur Cape area. Dir ect abso lute altimeter calibration , and mapping of the sea surface, w ere made in these camp aigns from dir ect overflights using GPS buoys with a toroidal design performed at the I CC based in the orig inal design of the Univ ersity of Colorado at Boulder and a estimation of the TOPEX A lt- B bias w as made. A Spanish JASON-1 geoid gradien t campaign with Fench support has been made in June 2003 at the Ibiza island in the NW Mediterr anean Sea. Th e main objectiv e has b een to map w ith a new d esign ed, builded and calibrated GPS catamar an, the lo cal geoid gradien t in three ar eas around Ibiza island under the ascending (187) and descending (248) Jason-1ground tracks. The catamaran equ ipped with two GPS antennas to perform continuous sea lev el measur ements was towed by the Patro l Dev a from th e Span ish N avy. Five GPS reference stations were dep loyed on Ibiza island: one in Portinatx, two in San Anton io and two in Ibiza. The marin e geo id has been used to relate the coastal tide gauge data from Ibiza and San An tonio h arbours to off- shore altimetric data. In th e framework of the campaign, the levelling of the Ibiza and San Anton io tide gauges to the r espective GPS mark ers w as p erformed. We present synth esis of the resu lts obtained from Topex/Poseidon and th e first r esults on Jason-1 altimeter calibration using the direct measurements from GPS buoys and the derived marin e geoid. Th e Ibiza results agree relativ ely w ell with resu lts ob tained at Corsica, Harvest and Bass Strait calibration permanen t sites. Moreov er, the geod etic activities (e.g., GPS, levelling) has p ermitted to build a very accurate (few mm) local n etwork link ed to th e European one, w ith a reference frame compatible with th e satellite altimetry missions (ITRF2000). The GPS

  14. Sticky situations: recent advances in control of cell adhesion during neuronal migration.

    PubMed

    Solecki, David J

    2012-10-01

    The migration of neurons along glial fibers from a germinal zone (GZ) to their final laminar positions is essential for morphogenesis of the developing brain; aberrations in this process are linked to profound neurodevelopmental and cognitive disorders. During this critical morphogenic movement, neurons must navigate complex migration paths, propelling their cell bodies through the dense cellular environment of the developing nervous system to their final destinations. It is not understood how neurons can successfully migrate along their glial guides through the myriad processes and cell bodies of neighboring neurons. Although much progress has been made in understanding the substrates (Fishell G, Hatten ME: Astrotactin provides a receptor system for CNS neuronal migration. Development 1991, 113:755; Elias LA, Wang DD, Kriegstein AR: Gap junction adhesion is necessary for radial migration in the neocortex. Nature 2007, 448:901; Anton ES, Kreidberg JA, Rakic P: Distinct functions of alpha3 and alpha. (v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Neuron 1999, 22:277; Anton ES, Marchionni MA, Lee KF, Rakic P: Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124:3501), guidance mechanisms (Polleux F, Whitford KL, Dijkhuizen PA, Vitalis T, Ghosh A: Control of cortical interneuron migration by neurotrophins and PI3-kinase signaling. Development 2002, 129:3147; Zhou P, et al.: Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron 2007, 55:53; Renaud J, et al.: Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells. Nat Neurosci 2008, 11:440), cytoskeletal elements (Schaar BT, McConnell SK: Cytoskeletal coordination during neuronal migration. Proc Natl Acad Sci U S A 2005, 102:13652; Tsai JW, Bremner KH, Vallee RB: Dual subcellular roles for LIS1

  15. Modeling and Assessing Insect Disturbance on Boreal Forests in the Krasnoyarsk region of Russia by Employing the FAREAST Gap Model and Local Forest Inventory and Disturbance Data.

    NASA Astrophysics Data System (ADS)

    Erler, A. E.; Shuman, J. K.; Soukhavolosky, V.; Kovalev, A.; Stevens, T.; Shugart, H. H.

    2008-12-01

    FAREAST: an individual-based forest dynamics model was initially developed to simulate the forested region around Changbai Mountain in northern China. In recent years the model has been expanded across Siberia. The model output for biomass (tCha-1) has been verified against forest inventory data for a number of sites across Russia. With this success, an additional module for the model was written by Anton Kovalev to predict the impact of insect disturbance on the Boreal forests. This model predicts the probability of an insect outbreak occurring, and then, by assessing each individual tree in a modeled stand, predicts whether a tree will be killed as a result of insect predation. From this, a disturbance index is calculated that includes lost biomass as a result of insect disturbance and subsequent species composition. This disturbance "fingerprint" is being compared to forest inventory and insect disturbance data from the Usolsky forests in the Krasnoyarsk region of central Siberia. Silkworm disturbance is expressed in this geo- database as a percentage of trees damaged or killed in a stand. The forest inventory data allows us to calculate a biomass estimate that will be compared to the biomass outputs generated by the model post insect disturbance. The validation of simulated biomass with independent inventory data confirms that FAREAST is a robust model of Russian forest dynamics. Effective validation of the insect disturbance model will allow us to generate a more complete picture of the changing ecology of the Siberian Boreal landscape. The economic cost of lumber lost as a result of Silkworm damage has been enormous, if verified, FAREAST will afford us the opportunity to estimate the extent of that loss and predict the changing ecological dynamics of the Boreal forest system under the worlds evolving climate.

  16. Psychoanalytic listening II.

    PubMed

    Chessick, R D

    1985-01-01

    This paper employs a rhetorical form designed to clarify and sharpen the focus of the very special stance required--which must be painstakingly learned under careful supervision--in order to effectively tune in to communications coming from the unconscious of the patient. This is the hardest task that must be mastered to become truly empathic and sensitive in dyadic relationships, a unique expertise that marks the psychiatrist as a genuine specialist in medical practice. Regardless of theoretical orientation, neither the form or content of any therapeutic intervention can be appropriate unless it is empathically based. Clinical vignettes illustrate the lack of such empathy, and readings are suggested that enhance our approach to learning this skill, borrowing especially from Kohut and Bion. The great importance of the often ignored "background" of the patient's communication is emphasized, and is illustrated from the field of music in the work of John Cage and Anton Webern. The congruence between this clinical psychiatric problem and the main thrust of Continental philosophy, which attempts to put man back in touch with himself, is described. Suggestions are offered to supervisors how to develop these skills in the novice. Finally, a discussion is presented of the effect on the professional and personal life of the therapist who has not developed these skills, emphasizing the dangers of "burn-out" in therapists and the implicit philosophy of life in a money-oriented practice of psychotherapy. The dangers of not attending to such matters even during residency training are pointed out, in an attempt to raise the consciousness level of the therapist to the extreme importance of background practices both in the patient and the therapist.

  17. Doctor Chekhov's doctors.

    PubMed

    Crommelynck, Isabelle

    2013-01-01

    Anton Chekhov (1860-1904) was both a writer and a doctor, as well as a patient. In spite of his literary success, he did not turn away from medicine until 1897, at the age of 37, when his tuberculosis became too serious. During his medical studies in Moscow, he wrote short stories, at night, under various pseudonyms to provide money for his family; all his life, Chekhov was his parents' financial support. It was Alexei Suvorin (1834-1912), the powerful director of Novoye Vremya (New Times), and the well-known writer Dimitry Grigorovich (1822-1899) who persuaded him that he had exceptional literary talent and requested him to abandon pseudonyms and sign his articles. So, for all his life, he practiced medicine as a district doctor and wrote plays and short stories. In each of his plays, except The Cherry Orchard, Chekhov introduced characters of doctors, principally Yevgeny Konstantinovich Lvov in Ivanov and Mikhail Lvovich Astrov in Uncle Vanya, as well as Khrushchev in The Wood Demon, Dorn in The Seagull, Tcheboutykin in The Three Sisters, and Triletski in Platonov. In his countless short stories, there are numerous doctors, for instance Professor Stepanovich (A Dreary Story), Doctors Kirilov (Enemies), Sobol (My Wife), Outchinnikov (An Inconvenience), Dymov (The Grasshopper), Startsvev (Ionitch), and others. Chekhov's main interest in psychiatry was clearly visible in The Nervous Breakdown, The Black Monk, The Man in a Case, A Doctor's Visit, and WardNo. 6 with Dr. Ragin. In his short stories as in his plays, Chekhov relied on his knowledge of provincial life; his doctor's characters were not professors, academicians, or Moscow's great physicians, but instead exhausted hard workers, with no effective diagnostic and therapeutic means, and poorly paid. Unlike himself, none of Chekhov's doctors was a writer or breadwinner, and Chekhov did not like to lay emphasis on the disease.

  18. Rheological analysis of an effect of different deflocculants on the fly-ash slurry

    NASA Astrophysics Data System (ADS)

    Sarnecki, K.; Bartosik, A.

    2014-08-01

    During the combustion of coal in the combined heat and power plant (CHP), a very large amount of combustion waste, called further as a fly-ash, is produced. It is typical that fly-ash appears during the combustion process of the fine coal and is transported by a pipeline with support of water as a carrier liquid to a pond storage site, where it is disposed. The pond is localized usually a few kilometers from the CHP, which makes it possible that decrease of friction in such a pipeline can result in energy savings of electricity needed for the pump and water needed as a carrier liquid. In the study an efficient method using a few deflocculants for reducing shear stress, and as a consequence viscosity, is demonstrated. The objective of the paper is to improve the efficiency of the hydrotransport of the fly-ash slurry by adding own designed additives. During the experiments a solids concentration by weight was determined from procured raw material in order to compute the real value occurring in industrial conditions. In addition, the analysis of the particle size distribution was conducted. The Anton Paar MCR 302 electronic rheometer was used to measure the dependence of shear stress and viscosity vs shear rate in the fly-ash existing in the CHP. Another part of the analysis was focused on the additives (deflocculants), to examine their influence on the reduction of the shear stress. The paper proves positive deflocculants impact on the rheological properties of the fly-ash slurry. The results of measurements are presented as figures and conclusions.

  19. Energy landscape of LeuT from molecular simulations

    NASA Astrophysics Data System (ADS)

    Gur, Mert; Zomot, Elia; Cheng, Mary Hongying; Bahar, Ivet

    2015-12-01

    The bacterial sodium-coupled leucine transporter (LeuT) has been broadly used as a structural model for understanding the structure-dynamics-function of mammalian neurotransmitter transporters as well as other solute carriers that share the same fold (LeuT fold), as the first member of the family crystallographically resolved in multiple states: outward-facing open, outward-facing occluded, and inward-facing open. Yet, a complete picture of the energy landscape of (sub)states visited along the LeuT transport cycle has been elusive. In an attempt to visualize the conformational spectrum of LeuT, we performed extensive simulations of LeuT dimer dynamics in the presence of substrate (Ala or Leu) and co-transported Na+ ions, in explicit membrane and water. We used both conventional molecular dynamics (MD) simulations (with Anton supercomputing machine) and a recently introduced method, collective MD, that takes advantage of collective modes of motions predicted by the anisotropic network model. Free energy landscapes constructed based on ˜40 μs trajectories reveal multiple substates occluded to the extracellular (EC) and/or intracellular (IC) media, varying in the levels of exposure of LeuT to EC or IC vestibules. The IC-facing transmembrane (TM) helical segment TM1a shows an opening, albeit to a smaller extent and in a slightly different direction than that observed in the inward-facing open crystal structure. The study provides insights into the spectrum of conformational substates and paths accessible to LeuT and highlights the differences between Ala- and Leu-bound substates.

  20. Magneto-optical and rheological behaviors of oil-based ferrofluids and magnetorheological fluids

    NASA Astrophysics Data System (ADS)

    Getzie, Travis

    The magneto-optical and rheological behaviors of magnetic fluids and magnetorheological (MR) fluids have been investigated. A magneto-optical apparatus was constructed which enabled us to investigate the birefringence and dichroism of ferrofluids at various levels of applied magnetic field. Specifically, the effects of the film thickness of oil-based ferrofluids and the concentration of surfactant in the oil-based ferrofluids on their magneto-optical behavior were investigated. A commercial magneto-rheological instrument (Physica MCR 301, Anton Paar) equipped with a cone-and-plate fixture was employed to investigate the transient and steady-state shear flow of both ferrofluids and MR fluids as a function of shear rate at various levels of applied magnetic fields. The rheological investigation has enabled us to determine the effect of applied magnetic field on the shear viscosity and yield stress of ferrofluids and MR fluids. A special ferrofluid was prepared by filtering out nearly all of the surfactant and small particles in an oil-based ferrofluid. We then compared its magneto-optical and rheological behaviors with those of an unfiltered ferrofluid. Further, we have found that the ferrofluid with a lower concentration of surfactant gave rise to larger birefringence and yield stress, and stronger shear thinning behavior than the ferrofluid containing a higher concentration of surfactant. This observation has lead us to conclude that an increase in unbound surfactant in a ferrofluid hindered chain formation of magnetic particles, leading to a decrease in the optical and rheological behaviors of the ferrofluid. Optical microscopy confirmed no visible chain formation of magnetic particles in the ferrofluid having a high concentration of surfactant owing to weak yield stress, birefringence, and shear thinning. On the other hand, we observed from optical microscopy that the filtered ferrofluid gave rise to larger yield stress, birefringence, and stronger shear thinning

  1. High-bootstrap, noninductively sustained electron internal transport barriers in the Tokamak a Configuration Variable

    SciTech Connect

    Coda, S.; Goodman, T.P.; Henderson, M.A.; Sauter, O.; Behn, R.; Bottino, A.; Camenen, Y.; Fable, E.; Martynov, An.; Nikkola, P.; Scarabosio, A.; Zhuang, G.; Zucca, C.

    2005-05-15

    Important ingredients of the advanced-tokamak route to fusion have been explored in depth in the Tokamak a Configuration Variable [F. Hofmann, J. B. Lister, M. Anton et al., Plasma Phys. Controlled Fusion 36, B277 (1994)] over the past two years. Using a uniquely powerful and flexible electron-cyclotron resonance heating (ECRH) system as the primary actuator, fully noninductive, steady-state electron internal transport barrier discharges have been generated with an electron-energy confinement time up to five times longer than in L mode, poloidal {beta} up to 2.4, and bootstrap fraction up to 75%. Interpretative transport modeling confirms that the safety factor profile is nonmonotonic in these discharges. The formation of the barrier is a discrete event resulting in rapid and localized confinement improvement consistent with the time and location of magnetic-shear reversal. In steady state, however, the confinement quality appears to depend on the current gradient in a broader negative-shear region enclosed by the barrier, improving with increasing shear: in particular, the width and depth of the barrier can be controlled and finely tuned, along a magnetohydrodynamic-stable path, by manipulating the current profile with ECRH (six independently steerable 0.45 MW launchers). The crucial role of the current profile has been clearly demonstrated by applying small Ohmic current perturbations which dramatically alter the properties of the barrier, enhancing or reducing the confinement with negative and positive current, respectively, with negligible Ohmic heating. These results are in agreement with theoretical estimates: first-principle-based numerical simulations of microinstability dynamics and turbulence-driven transport predict a substantial suppression of turbulence and anomalous energy diffusivity near the location of the minimum in the safety factor.

  2. Participation of D.O. Muhleman as a Co-Investigator on the Mars Observer Laser Altimeter (MOLA) Team

    NASA Technical Reports Server (NTRS)

    Muhleman, Duane O.

    2004-01-01

    The Co-I has been a principle member of the MOLA Team since the beginning of the Mars Observer Project and the MOLA Team formation. The basic area of research for the Co-I involved the interactions of the MOLA laser beam with the Mars atmosphere, ice fields and surface in general. The Co-I was assisted by one graduate student, and later a research assistant, Anton Ivanov, throughout the reporting period. Dr. Ivanov received a PhD from Caltech in 2000 from research involving the MOLA project. Dr. Ivanov continued with the MOLA project after receiving his degree as a research assistant to Professor Muhleman. Most of the funding from this grant was used to support Dr. Ivanov during the later years. The primary results of these investigations included the measurement of Mars atmospheric opacity at the 1 micron wavelength of the laser, the effects of dust within the craters and canyons of Mars, and a detailed study of the North Polar Ice Cap in terms of ice sublimation and the current structure of that ice cap. We were able to show that the sublimation of the ice on the polar cap would create the current average shape of the norther cap. Extensive data collection and study were made of the Mars surface 1 micron reflectivity until the laser mechanically failed during the reporting period. Reflectivity maps of Mars were produced although there were serious problems of the laser echo signal strength calibration. After that event the efforts were mainly to complete the older investigations. All of the work supported by this grant was theoretical in nature and did not lead to any patents.

  3. Changes in visual and sensory-motor resting-state functional connectivity support motor learning by observing.

    PubMed

    McGregor, Heather R; Gribble, Paul L

    2015-07-01

    Motor learning occurs not only through direct first-hand experience but also through observation (Mattar AA, Gribble PL. Neuron 46: 153-160, 2005). When observing the actions of others, we activate many of the same brain regions involved in performing those actions ourselves (Malfait N, Valyear KF, Culham JC, Anton JL, Brown LE, Gribble PL. J Cogn Neurosci 22: 1493-1503, 2010). Links between neural systems for vision and action have been reported in neurophysiological (Strafella AP, Paus T. Neuroreport 11: 2289-2292, 2000; Watkins KE, Strafella AP, Paus T. Neuropsychologia 41: 989-994, 2003), brain imaging (Buccino G, Binkofski F, Fink GR, Fadiga L, Fogassi L, Gallese V, Seitz RJ, Zilles K, Rizzolatti G, Freund HJ. Eur J Neurosci 13: 400-404, 2001; Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G. Science 286: 2526-2528, 1999), and eye tracking (Flanagan JR, Johansson RS. Nature 424: 769-771, 2003) studies. Here we used a force field learning paradigm coupled with resting-state fMRI to investigate the brain areas involved in motor learning by observing. We examined changes in resting-state functional connectivity (FC) after an observational learning task and found a network consisting of V5/MT, cerebellum, and primary motor and somatosensory cortices in which changes in FC were correlated with the amount of motor learning achieved through observation, as assessed behaviorally after resting-state fMRI scans. The observed FC changes in this network are not due to visual attention to motion or observation of movement errors but rather are specifically linked to motor learning. These results support the idea that brain networks linking action observation and motor control also facilitate motor learning. PMID:25995349

  4. Changes in visual and sensory-motor resting-state functional connectivity support motor learning by observing.

    PubMed

    McGregor, Heather R; Gribble, Paul L

    2015-07-01

    Motor learning occurs not only through direct first-hand experience but also through observation (Mattar AA, Gribble PL. Neuron 46: 153-160, 2005). When observing the actions of others, we activate many of the same brain regions involved in performing those actions ourselves (Malfait N, Valyear KF, Culham JC, Anton JL, Brown LE, Gribble PL. J Cogn Neurosci 22: 1493-1503, 2010). Links between neural systems for vision and action have been reported in neurophysiological (Strafella AP, Paus T. Neuroreport 11: 2289-2292, 2000; Watkins KE, Strafella AP, Paus T. Neuropsychologia 41: 989-994, 2003), brain imaging (Buccino G, Binkofski F, Fink GR, Fadiga L, Fogassi L, Gallese V, Seitz RJ, Zilles K, Rizzolatti G, Freund HJ. Eur J Neurosci 13: 400-404, 2001; Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G. Science 286: 2526-2528, 1999), and eye tracking (Flanagan JR, Johansson RS. Nature 424: 769-771, 2003) studies. Here we used a force field learning paradigm coupled with resting-state fMRI to investigate the brain areas involved in motor learning by observing. We examined changes in resting-state functional connectivity (FC) after an observational learning task and found a network consisting of V5/MT, cerebellum, and primary motor and somatosensory cortices in which changes in FC were correlated with the amount of motor learning achieved through observation, as assessed behaviorally after resting-state fMRI scans. The observed FC changes in this network are not due to visual attention to motion or observation of movement errors but rather are specifically linked to motor learning. These results support the idea that brain networks linking action observation and motor control also facilitate motor learning.

  5. Microgravity can activate signals urging cells to S-phase entry during tissue and organ regeneration in Urodele amphibians exposed to real and simulated microgravity

    NASA Astrophysics Data System (ADS)

    Grigoryan, E.; Anton, H.-J.; Mitashov, V.

    Regenerative response following local injury or tissue removal in urodele amphibians is dependent on cell cycle entry of cells sources for regeneration in the remaining tissue. In a number of our experiments performed aboard biosatellites in orbital flights and fast rotated clinostat we found enhanced proliferative activity and, as a result, regeneration quicker than that in controls. In each investigated case an activity of cell proliferation evaluated by 3H-thymidine radioautography and BrdU assay at the early stages of lens, retina, forelimb and tail regeneration in newts was about 1,2-1,7 fold higher both under conditions of real and physiological weightlessness as compared with controls. Faster S-phase entry under conditions of micro- g was demonstrated by cycling multipotent cells as well as by differentiated postmitotic cells both participated in regeneration. Important, that cycling cells outside areas of regeneration were also found as displayed faster cellular growth. In our papers (1,2,3,4) we offered some hypothesis that could explain mechanisms of low g stimulating effect upon cell growth in regeneration in Urodela. In particular, changes in expression of some growth factors and their receptors, as well as the synthesis of specific range of generalized stress proteins (AGSPs) were proposed. However, in fact, molecular mechanisms of micro- g effect upon cell proliferation are mediated by changes on organismic level induced by micro- g environment. Some of them which are able to trigger off signaling changes on the cellular level that, in turn, evoke cells to grow faster would be represented in our report. 1. Mitashov V. et al. Adv. Space Res. 1996. 17 (6/7): 241-255 2. Anton H.-J. et al. Adv. Space Res. 1996. 17 (6/7): 55-65 3. Grigoryan E. et al. Adv. Space Res. 1998. 22 (2): 293-301 4. Grigoryan E. et al. Adv. Space Res. 2002. 30 (4): 757-764

  6. Applications and Implications of Fractional Dynamics for Dielectric Relaxation

    NASA Astrophysics Data System (ADS)

    Hilfer, R.

    This article summarizes briefly the presentation given by the author at the NATO Advanced Research Workshop on "Broadband Dielectric Spectroscopy and its Advanced Technological Applications", held in Perpignan, France, in September 2011. The purpose of the invited presentation at the workshop was to review and summarize the basic theory of fractional dynamics (Hilfer, Phys Rev E 48:2466, 1993; Hilfer and Anton, Phys Rev E Rapid Commun 51:R848, 1995; Hilfer, Fractals 3(1):211, 1995; Hilfer, Chaos Solitons Fractals 5:1475, 1995; Hilfer, Fractals 3:549, 1995; Hilfer, Physica A 221:89, 1995; Hilfer, On fractional diffusion and its relation with continuous time random walks. In: Pekalski et al. (eds) Anomalous diffusion: from basis to applications. Springer, Berlin, p 77, 1999; Hilfer, Fractional evolution equations and irreversibility. In: Helbing et al. (eds) Traffic and granular flow'99. Springer, Berlin, p 215, 2000; Hilfer, Fractional time evolution. In: Hilfer (ed) Applications of fractional calculus in physics. World Scientific, Singapore, p 87, 2000; Hilfer, Remarks on fractional time. In: Castell and Ischebeck (eds) Time, quantum and information. Springer, Berlin, p 235, 2003; Hilfer, Physica A 329:35, 2003; Hilfer, Threefold introduction to fractional derivatives. In: Klages et al. (eds) Anomalous transport: foundations and applications. Wiley-VCH, Weinheim, pp 17-74, 2008; Hilfer, Foundations of fractional dynamics: a short account. In: Klafter et al. (eds) Fractional dynamics: recent advances. World Scientific, Singapore, p 207, 2011) and demonstrate its relevance and application to broadband dielectric spectroscopy (Hilfer, J Phys Condens Matter 14:2297, 2002; Hilfer, Chem Phys 284:399, 2002; Hilfer, Fractals 11:251, 2003; Hilfer et al., Fractional Calc Appl Anal 12:299, 2009). It was argued, that broadband dielectric spectroscopy might be useful to test effective field theories based on fractional dynamics.

  7. The lost origin of chemical ecology in the late 19th century.

    PubMed

    Hartmann, Thomas

    2008-03-25

    The origin of plant chemical ecology generally dates to the late 1950s, when evolutionary entomologists recognized the essential role of plant secondary metabolites in plant-insect interactions and suggested that plant chemical diversity evolved under the selection pressure of herbivory. However, similar ideas had already flourished for a short period during the second half of the 19th century but were largely forgotten by the turn of the century. This article presents the observations and studies of three protagonists of chemical ecology: Anton Kerner von Marilaun (1831-1898, Innsbruck, Austria, and Vienna, Austria), who mainly studied the impact of geological, climatic, and biotic factors on plant distribution and survival; Léo Errera (1858-1906, Brussels, Belgium), a plant physiologist who analyzed the localization of alkaloids in plant cells and tissues histochemically; and Ernst Stahl (1848-1919, Jena, Germany), likely the first experimental ecologist and who performed feeding studies with snails and slugs that demonstrated the essential role of secondary metabolites in plant protection against herbivores. All three, particularly Stahl, suggested that these "chemical defensive means" evolved in response to the relentless selection pressure of the heterotrophic community that surrounds plants. Although convincingly supported by observations and experiments, these ideas were forgotten until recently. Now, more than 100 years later, molecular analysis of the genes that control secondary metabolite production underscores just how correct Kerner von Marilaun, Errera, and, particularly, Stahl were in their view. Why their ideas were lost is likely a result of the adamant rejection of all things "teleological" by the physiologists who dominated biological research at the time. PMID:18218780

  8. Relative response of the alanine dosimeter to medium energy x-rays.

    PubMed

    Anton, M; Büermann, L

    2015-08-01

    The response of the alanine dosimeter to kilovoltage x-rays with respect to the dose to water was measured, relative to the response to Co-60 radiation.Two series of x-ray qualities were investigated, one ranging from 30 kV to 100 kV tube voltage (TW series), the other one ranging from 70 kV to 280 kV (TH series). Due to the use of the water calorimeter as a primary standard, the uncertainty of the delivered dose is significantly lower than for other published data. The alanine response was measured as described in a previous publication (Anton et al 2013 Phys. Med. Biol. 58 3259-82). The uncertainty component due to the alanine measurement and analysis is ⩽0.4%, the major part of the combined uncertainty of the relative response originates from the uncertainty of the delivered dose. The relative uncertainties of the relative response vary from ⩽2% for the TW series to ⩽1.1% for the TH series.Different from the behaviour of the alanine dosimeter for megavoltage x-rays or electrons, the relative response drops significantly from unity for Co-60 radiation to less than 64% for the TW quality with a tube voltage of 30 kV. In order to reproduce this behaviour through Monte Carlo simulations, not only the ratio of the absorbed dose to alanine to the absorbed dose to water has to be known, but also the intrinsic efficiency, i.e. the dependence of the number of free radicals generated per unit of absorbed dose on the photon energy. This quantity is not yet accessible for the TW series.For a possible use of the alanine dosimeter for kilovoltage x-rays, for example in electronic brachytherapy, users should rely on the measured data for the relative response which have become available with this publication. PMID:26216572

  9. The lost origin of chemical ecology in the late 19th century

    PubMed Central

    Hartmann, Thomas

    2008-01-01

    The origin of plant chemical ecology generally dates to the late 1950s, when evolutionary entomologists recognized the essential role of plant secondary metabolites in plant–insect interactions and suggested that plant chemical diversity evolved under the selection pressure of herbivory. However, similar ideas had already flourished for a short period during the second half of the 19th century but were largely forgotten by the turn of the century. This article presents the observations and studies of three protagonists of chemical ecology: Anton Kerner von Marilaun (1831–1898, Innsbruck, Austria, and Vienna, Austria), who mainly studied the impact of geological, climatic, and biotic factors on plant distribution and survival; Léo Errera (1858–1906, Brussels, Belgium), a plant physiologist who analyzed the localization of alkaloids in plant cells and tissues histochemically; and Ernst Stahl (1848–1919, Jena, Germany), likely the first experimental ecologist and who performed feeding studies with snails and slugs that demonstrated the essential role of secondary metabolites in plant protection against herbivores. All three, particularly Stahl, suggested that these “chemical defensive means” evolved in response to the relentless selection pressure of the heterotrophic community that surrounds plants. Although convincingly supported by observations and experiments, these ideas were forgotten until recently. Now, more than 100 years later, molecular analysis of the genes that control secondary metabolite production underscores just how correct Kerner von Marilaun, Errera, and, particularly, Stahl were in their view. Why their ideas were lost is likely a result of the adamant rejection of all things “teleological” by the physiologists who dominated biological research at the time. PMID:18218780

  10. Relative response of the alanine dosimeter to medium energy x-rays

    NASA Astrophysics Data System (ADS)

    Anton, M.; Büermann, L.

    2015-08-01

    The response of the alanine dosimeter to kilovoltage x-rays with respect to the dose to water was measured, relative to the response to Co-60 radiation. Two series of x-ray qualities were investigated, one ranging from 30 kV to 100 kV tube voltage (TW series), the other one ranging from 70 kV to 280 kV (TH series). Due to the use of the water calorimeter as a primary standard, the uncertainty of the delivered dose is significantly lower than for other published data. The alanine response was measured as described in a previous publication (Anton et al 2013 Phys. Med. Biol. 58 3259-82). The uncertainty component due to the alanine measurement and analysis is ⩽0.4%, the major part of the combined uncertainty of the relative response originates from the uncertainty of the delivered dose. The relative uncertainties of the relative response vary from ⩽2% for the TW series to ⩽1.1% for the TH series. Different from the behaviour of the alanine dosimeter for megavoltage x-rays or electrons, the relative response drops significantly from unity for Co-60 radiation to less than 64% for the TW quality with a tube voltage of 30 kV. In order to reproduce this behaviour through Monte Carlo simulations, not only the ratio of the absorbed dose to alanine to the absorbed dose to water has to be known, but also the intrinsic efficiency, i.e. the dependence of the number of free radicals generated per unit of absorbed dose on the photon energy. This quantity is not yet accessible for the TW series. For a possible use of the alanine dosimeter for kilovoltage x-rays, for example in electronic brachytherapy, users should rely on the measured data for the relative response which have become available with this publication.

  11. Relative response of the alanine dosimeter to medium energy x-rays.

    PubMed

    Anton, M; Büermann, L

    2015-08-01

    The response of the alanine dosimeter to kilovoltage x-rays with respect to the dose to water was measured, relative to the response to Co-60 radiation.Two series of x-ray qualities were investigated, one ranging from 30 kV to 100 kV tube voltage (TW series), the other one ranging from 70 kV to 280 kV (TH series). Due to the use of the water calorimeter as a primary standard, the uncertainty of the delivered dose is significantly lower than for other published data. The alanine response was measured as described in a previous publication (Anton et al 2013 Phys. Med. Biol. 58 3259-82). The uncertainty component due to the alanine measurement and analysis is ⩽0.4%, the major part of the combined uncertainty of the relative response originates from the uncertainty of the delivered dose. The relative uncertainties of the relative response vary from ⩽2% for the TW series to ⩽1.1% for the TH series.Different from the behaviour of the alanine dosimeter for megavoltage x-rays or electrons, the relative response drops significantly from unity for Co-60 radiation to less than 64% for the TW quality with a tube voltage of 30 kV. In order to reproduce this behaviour through Monte Carlo simulations, not only the ratio of the absorbed dose to alanine to the absorbed dose to water has to be known, but also the intrinsic efficiency, i.e. the dependence of the number of free radicals generated per unit of absorbed dose on the photon energy. This quantity is not yet accessible for the TW series.For a possible use of the alanine dosimeter for kilovoltage x-rays, for example in electronic brachytherapy, users should rely on the measured data for the relative response which have become available with this publication.

  12. PREFACE: Eurotherm Seminar 102: Thermal Management of Electronic Systems

    NASA Astrophysics Data System (ADS)

    Punch, J.; Walsh, E.

    2014-07-01

    About EUROTHERM The aim of the EUROTHERM Committee (www.eurothermcommittee.eu) is to promote and foster European cooperation in Thermal Sciences and Heat Transfer by gathering together scientists and engineers working in specialized areas. The Committee consists of members representing and appointed by national bodies in the EU countries. The current President of EUROTHERM is Professor Anton van Steenhoven from the University of Eindhoven (The Netherlands). The Committee organizes and coordinates European scientific events such as the EUROTHERM Seminars (about 4 per year) and the European Thermal Sciences Conference (every 4 years). About EUROTHERM Seminar 102 (www.eurothermseminar102.com) This seminar, part of the long-running series of European seminars on the thermal sciences, took place in June 2014 at the University of Limerick in Limerick, Ireland. The seminar addressed the topic of 'Thermal Management of Electronic Systems', a critical contemporary application area which represents a vibrant challenge for practitioners of the thermal sciences. We convey special thanks to the reviewers who have evaluated these papers. We also thank the scientific committee, consisting of internationally recognized experts. Their role has been to manage the evaluation of abstracts and the papers selection process as co-coordinators for specific topics. This seminar was hosted by the Stokes Institute at the University of Limerick. It could not have been organized without the efficient help of our administrators and technicians for IT support. This volume of Journal of Physics: Conference Series includes 27 articles presented at the seminar. Dr. Jeff Punch, Chair Stokes Institute, University of Limerick, Limerick, Ireland Email: jeff.punch@ul.ie Prof. Edmond Walsh, Co-Chair Associate Professor, Osney Laboratories, Department of Engineering Science, University of Oxford, UK Email: edmond.walsh@bnc.ox.ac.uk

  13. PREFACE: 2nd International School and Conference Saint-Petersburg OPEN on Optoelectronics, Photonics, Engineering and Nanostructures (SPbOPEN2015)

    NASA Astrophysics Data System (ADS)

    2015-11-01

    The 2nd International School and Conference ''Saint Petersburg OPEN 2015'' on Optoelectronics, Photonics, Engineering and Nanostructures was held on April 6 - 8, 2015 at St. Petersburg Academic University. The School and Conference included a series of invited talks given by leading professors with the aim to introduce young scientists with actual problems and major advances in physics and technology. The keynote speakers were Mikhail V. Maximov (Ioffe Physico-Technical Institute RAS, Russia) Vladimir G. Dubrovskii (St. Petersburg Academic University and St. Petersburg State University, Russia) Anton Yu. Egorov (JSC Connector Optics, Russia) Victor V. Luchinin (St. Petersburg State Electrotechnical University, Russia) Vladislav E. Bugrov (St. Petersburg University of Internet Technologies, Mechanics and Optics, Russia) Vitali A. Schukin (VI Systems, Germany) Yuri P. Svirko (University of Eastern Finland, Finland) During the poster session all undergraduate and graduate students attending the conference presented their works. A sufficiently large number of participants, with more than 170 student attendees from all over the world, allowed the Conference to provide a fertile ground for fruitful discussions between the young scientists as well as to become a perfect platform for valuable discussions between student authors and highly experienced scientists. The best student papers, which were selected by the Program Committee and by the invited speakers basing on the theses and their poster presentation, were awarded with diplomas of the conference - see the photos. This year ''Saint Petersburg OPEN 2015'' is organized by St. Petersburg Academic University in cooperation with Peter the Great St. Petersburg Polytechnic University. The School and Conference is supported by Russian Science Foundation, SPIE (The International Society for Optics and Photonics), OSA (The Optical Society) and by Skolkovo Foundation. It is a continuation of the annual schools and seminars for

  14. The Works of Henry Moseley, 1887-1915

    NASA Astrophysics Data System (ADS)

    Scerri, Eric

    2013-04-01

    In 1913 Henry Moseley, an unknown young English physicist published an article in the Philosophical Magazine under the title of ``The High Frequency Spectra of the Elements.'' The 10-page article was to have far reaching implications in both chemistry and physics and helped to resolve a major conundrum in the periodic table of the elements. The talk will briefly examine the life and work of Moseley who died tragically while fighting in the trenches of World War I in 1915. The build-up to the discovery of atomic number took several different avenues including contributions from Rutherford and Barkla. However the more direct motivation for Moseley's work, as he readily acknowledged, were the articles of an unknown Dutch econometrician Anton Van den Broek who attempted to improve on Mendeleev's periodic table. Moseley began as a student of Rutherford at Manchester and took a keen interest in the development of research using X-rays following the work of Roentgen, von Laue and Bragg. Although Rutherford was at first reluctant to enter this new field he soon yielded to young Moseley's request and sent him to Leeds for brief training with Bragg. On returning to Manchester, Moseley devised an ingenious apparatus in which a set of metal samples could be rotated so as to become the target for a beam of electrons in order to measure the frequencies of the emitted K X-rays. The first set of such experiments used nine successive elements in the periodic table, from titanium to zinc. Moseley's now immense fame rests with the results of this study as well as a subsequent one which extended the study into a further 30 elements, in addition to the use that his method was put to by himself as well as subsequent chemists and physicists.

  15. PREFACE: 6th European Thermal Sciences Conference (Eurotherm 2012)

    NASA Astrophysics Data System (ADS)

    Petit, Daniel; Le Niliot, Christophe

    2012-11-01

    About EUROTHERM The aim of the EUROTHERM Committee (www.eurothermcommittee.eu) is to promote and foster European cooperation in Thermal Sciences and Heat Transfer by gathering together scientists and engineers working in specialized areas. The Committee consists of members representing and appointed by national bodies in the EU countries. The current President of EUROTHERM is Professor Anton van Steenhoven from the University of Eindhoven (The Netherlands). The Committee organizes and coordinates European scientific events such as the EUROTHERM Seminars (about 4 per year) and the European Thermal Sciences Conference (every 4 years). About the conference This sixth in the series of European Thermal Sciences Conferences (www.eurotherm2012.com) took place in France, in the Conference Centre of Poitiers, Futuroscope. We address special thanks to the 225 reviewers, coming from different European countries, who have evaluated these papers. We also thank the scientific committee, consisting of some EUROTHERM Committee members together with other internationally recognized experts. Their role has been to manage the evaluation of abstracts and the papers selection process as co-coordinators for specific topics. This conference is the joint effort of two laboratories: the PPRIME Institute in Poitiers and the IUSTI laboratory in Marseille. It could not be organized without the efficient help of our secretaries and our technician for the IT support. This volume of Journal of Physics: Conference Series includes 180 articles presented at the conference. Professor Daniel PETIT Chairman, PPRIME Poitiers, France Institut P'(UPR CNRS 3346) ENSMA 1 av. Clément Ader - BP40109 86961 Futuroscope-Chasseneuil France daniel.petit@ensma.fr Professor Christophe LE NILIOT Co-chairman, IUSTI Marseille, France Laboratoire IUSTI UMR CNRS 6595 Technopôle de Chateau-Gombert 5, rue Enrico Fermi 13 453 MARSEILLE CEDEX 13 France christophe.leniliot@polytech.univ-mrs.fr

  16. The Archiv für Ohrenheilkunde (Archive of Otology): a structural analysis of the first 50 years (1864-1914).

    PubMed

    Peinhardt, Juliane; Plontke, Stefan K; Mudry, Albert; Steger, Florian

    2015-06-01

    In 1864, Anton von Tröltsch in Würzburg, Hermann Schwartze in Halle/Saale, and Adam Politzer in Vienna founded the Archiv für Ohrenheilkunde (Archive of Otology), the ancestor of the European Archives of Oto-Rhino-Laryngology and Head and Neck. It was the world's first journal solely devoted to otology, and thus to otorhinolaryngology. The aim of this study was to analyse the structure of this journal and its contents during the first 50 years of its publication, until it definitively became an otorhinolaryngological journal in 1915. A total of 2,271 articles were registered during this time. They were classified according to content topic, article type, and the number of figures and graphs that they contained. Almost three-quarters of the articles were related to purely otological topics, as implied by the journal's title. Until the turn of the twentieth century, the majority of the articles were original papers or case reports. The number of original papers declined over the decades in favour of case reports. One-third of each volume usually consisted of a vast variety of items, such as congress announcements, conference proceedings, and book reviews. The journal also maintained a wide variety of scientific and current social and political subjects. Otological reviews and conference proceedings were key landmarks of the journal. All of these various papers provided an overview of the historical organisation and development of otology between 1864 and 1914. At that time, the Archiv für Ohrenheilkunde was a leading national and international journal.

  17. [Medical cybernetics in Czechoslovakia--the first steps].

    PubMed

    Wünsch, Z

    1998-09-01

    During fifties there were at most few tens of persons in this country who believed in the future of computers and cybernetics. One group of such enthusiasts, headed by Antonín Svoboda, was working at a construction of the first Czech computer SAPO. The other group tried to analyse, anticipate, and prepare in advance various applications for the new systemic conceptions and for the information processing machines. Members of both groups met for discussions which opened prospects to the future and influenced many of other activities for a long time. At the early sixties, the Czechoslovak Cybernetic Society was established at the Czechoslovak Academy of Sciences and in 1962 the Main Problem Committee for the Medical Cybernetics was founded at the Department of Health. It coordinated majority of the research programmes in the medical cybernetics and informatics. In 1967-1969 the Committee prepared an extensive project of a medical information system (ZIS), but its accomplishment was finally blocked by the then authorities. However, interests for that topics kept growing and the new working places equipped with available computer technology were formed at the health and clinical centres. The first tentative lectures in medical cybernetics and biocybernetics at our faculty were introduced into the students curricula in the late sixties. Thematically, medical cybernetics subsequently differentiated into the medical informatics, simulations of biological and medical systems, and the biosignal analysis. The growing interest enabled to hold conferences since the middle of seventies, some of which were held periodically, sometimes with international participation. It is not possible in brevity to include the whole spectrum to those goal-directed activities nor to appraise adequately their future significance.

  18. From photoelectron detachment spectra of BrHBr(-), BrDBr(-) and IHI(-), IDI(-) to vibrational bonding of BrMuBr and IMuI.

    PubMed

    Manz, Jörn; Sato, Kazuma; Takayanagi, Toshiyuki; Yoshida, Takahiko

    2015-04-28

    Photoelectron detachment XLX(-)(00(0)0) + hν → XLX(vib) + e(-) + KER (X = Br or I, L = H or D) at sufficiently low temperatures photoionizes linear dihalogen anions XLX(-) in the vibrational ground state (v1v2 (l)v3 = 00(0)0) and prepares the neutral radicals XLX(vib) in vibrational states (vib). At the same time, part of the photon energy (hν) is converted into kinetic energy release (KER) of the electron [R. B. Metz, S. E. Bradforth, and D. M. Neumark, Adv. Chem. Phys. 81, 1 (1992)]. The process may be described approximately in terms of a Franck-Condon type transfer of the vibrational wavefunction representing XLX(-)(00(0)0) from the domain close to the minimum of its potential energy surface (PES) to the domain close to the linear transition state of the PES of the neutral XLX. As a consequence, prominent peaks of the photoelectron detachment spectra (pds) correlate with the vibrational energies EXLX,vib of states XLX(vib) which are centered at linear transition state. The corresponding vibrational quantum numbers may be labeled vib = (v1v2 (l)v3) = (00(0)v3). Accordingly, the related most prominent peaks in the pds are labeled v3. We construct a model PES which mimics the "true" PES in the domain of transition state such that it supports vibrational states with energies EXLX,pds,00(0)v3 close to the peaks of the pds labeled v3 = 0, 2, and 4. Subsequently, the same model PES is also used to calculate approximate values of the energies EXMuX,00(0)0 of the isotopomers XMuX(00(0)0). For the heavy isotopomers XHX and XDX, it turns out that all energies EXLX,00(0)v3 are above the threshold for dissociation, which means that all heavy XLX(00(0)v3) with wavefunctions centered at the transition state are unstable resonances with finite lifetimes. Turning the table, bound states of the heavy XLX are van der Waals (vdW) bonded. In contrast, the energies EXMuX,00(0)0 of the light isotopomers XMuX(00(0)0) are below the threshold for dissociation, with wavefunctions

  19. [The frequency of bacteria in human gallstones].

    PubMed

    Lévay, Bernadett; Szabó, Györgyi; Szijártó, Attila; Gamal, Eldin Mohamed

    2013-12-01

    Bevezetés: A hasüregben hagyott epekövek okozta septicus szövődmények jól ismertek az irodalomból. Hasüregi tályog, bélperforatio gyakran leírt szövődmény, de leírtak már epekövet sérvtömlőben is, sőt, hivatkozás történt egy betegre, aki expectorálta epekövét, amely a rekeszen át került be a légutakba néhány év alatt. A szövődmények megjelenése epeműtét után néhány héttől évekig tarthat. Anyagok és módszerek: A szerzők egymást követő 50 tervezett cholecystectomia (36 nő / 14 férfi, átlagéletkoruk: 60,8 ± 6,8 év) során minden hólyagból egy darab epekövet izoláltak, majd az ebből készített kőoldatot és epét mikrobiológiai vizsgálatra küldték, majd ezek eredményeit elemezték. Eredmények: A szerzők által kivett 50 darab epekőben 16 esetben fordult elő baktérium. Ebből 4 acut gyulladás jeleit mutató epehólyagból, 8 krónikusan gyulladt hólyagból, 4 epekő empyemás epehólyagból került vizsgálatra. Enterális kórokozó (Esherichia coli, Enterococcus faecalis, Enterobacter cloacae) 13 esetben, nem enterális (Klebsiella penumoniae, Streptococcus alfa-haemoliticus) 3 esetben volt jelen. Nőktől származó epehólyagban 12 esetben volt pozitív a tenyésztés, míg férfiaknál 4 esetben. Következtetések: Az epekövek egy részében baktériumok azonosíthatóak, amelyek felelősek lehetnek a későbbi gyulladásos szövődményekért.

  20. [Survey of quality of life of rheumatoid arthritis patients admitted to rehabilitation centres in Hungary].

    PubMed

    Sallai, Julianna Rozália; Hunka, Aniella; Héjj, Gábor; Ratkó, István; Ortutay, Judit; Márkus, Ilona; Ormos, Gábor; Ujfalussy, Andor; Szekeres, László; Insperger, Antal; Varjú, Tibor; Bálint, Géza

    2013-09-01

    Bevezetés: Hazai kórházakban rehabilitált, rheumatoid arthritisben szenvedő betegek életminősége kevéssé ismert. Célkitűzés: A szerzők négy hazai kórház reumatológiai rehabilitációs osztályán rehabilitációban részesülő 239 rheumatoid arthritises beteg (169 nő, 70 férfi) demográfiai adatainak, szociális helyzetének, betegségükkel kapcsolatos életminőségük, illetve tájékoztatás és támogatás iránti igényeik felmérését tűzték ki célul. Módszer: Az életminőséget validált Short Form 36 generikus életminőség kérdőívvel vizsgálták. A demográfiai, szociális és egyéb adatok felmérésére e célokra készített kérdőíveket alkalmaztak. Eredmények: Megállapították, hogy a rheumatoid arthritises betegek a diagnózis megállapítása után viszonylag korán kerülnek intézeti rehabilitációra. A betegek 80,4%-a 50 év feletti volt, és szociális helyzetük az átlagosnál rosszabbnak bizonyult. Életminőségük is szignifikánsan rosszabb volt, mint az átlagnépességé, de megfelelt az arthrosisban, osteoporosisban, illetve krónikus derékfájásban szenvedőkének. A betegek életminőség-kategóriái körül a fizikai működés és fájdalom pontszámai voltak a legalacsonyabbak. A kísérő betegségek közül a hypertonia és az osteoporosis volt a leggyakoribb. Térd- és csípőműtétek esetén a rehabilitációra megfelelő időben került sor. A betegségükkel kapcsolatos felvilágosítást és oktatást a betegek nem tartják kielégítőnek. Következtetések: Kórházban rehabilitált, rheumatoid arthritisben szenvedő betegeket a rossz életminőség jellemzi. A betegek tájékoztatása és oktatása javításra szorul. Orv. Hetil., 2013, 154, 1381–1388.

  1. From photoelectron detachment spectra of BrHBr-, BrDBr- and IHI-, IDI- to vibrational bonding of BrMuBr and IMuI

    NASA Astrophysics Data System (ADS)

    Manz, Jörn; Sato, Kazuma; Takayanagi, Toshiyuki; Yoshida, Takahiko

    2015-04-01

    Photoelectron detachment XLX-(0000) + hν → XLX(vib) + e- + KER (X = Br or I, L = H or D) at sufficiently low temperatures photoionizes linear dihalogen anions XLX- in the vibrational ground state (v1v2lv3 = 0000) and prepares the neutral radicals XLX(vib) in vibrational states (vib). At the same time, part of the photon energy (hν) is converted into kinetic energy release (KER) of the electron [R. B. Metz, S. E. Bradforth, and D. M. Neumark, Adv. Chem. Phys. 81, 1 (1992)]. The process may be described approximately in terms of a Franck-Condon type transfer of the vibrational wavefunction representing XLX-(0000) from the domain close to the minimum of its potential energy surface (PES) to the domain close to the linear transition state of the PES of the neutral XLX. As a consequence, prominent peaks of the photoelectron detachment spectra (pds) correlate with the vibrational energies EXLX,vib of states XLX(vib) which are centered at linear transition state. The corresponding vibrational quantum numbers may be labeled vib = (v1v2lv3) = (000v3). Accordingly, the related most prominent peaks in the pds are labeled v3. We construct a model PES which mimics the "true" PES in the domain of transition state such that it supports vibrational states with energies EXLX,pds,000v3 close to the peaks of the pds labeled v3 = 0, 2, and 4. Subsequently, the same model PES is also used to calculate approximate values of the energies EXMuX,0000 of the isotopomers XMuX(0000). For the heavy isotopomers XHX and XDX, it turns out that all energies EXLX,000v3 are above the threshold for dissociation, which means that all heavy XLX(000v3) with wavefunctions centered at the transition state are unstable resonances with finite lifetimes. Turning the table, bound states of the heavy XLX are van der Waals (vdW) bonded. In contrast, the energies EXMuX,0000 of the light isotopomers XMuX(0000) are below the threshold for dissociation, with wavefunctions centered at the transition state. This

  2. From photoelectron detachment spectra of BrHBr{sup −}, BrDBr{sup −} and IHI{sup −}, IDI{sup −} to vibrational bonding of BrMuBr and IMuI

    SciTech Connect

    Manz, Jörn; Sato, Kazuma; Takayanagi, Toshiyuki Yoshida, Takahiko

    2015-04-28

    Photoelectron detachment XLX{sup −}(00{sup 0}0) + hν → XLX(vib) + e{sup −} + KER (X = Br or I, L = H or D) at sufficiently low temperatures photoionizes linear dihalogen anions XLX{sup −} in the vibrational ground state (v{sub 1}v{sub 2}{sup l}v{sub 3} = 00{sup 0}0) and prepares the neutral radicals XLX(vib) in vibrational states (vib). At the same time, part of the photon energy (hν) is converted into kinetic energy release (KER) of the electron [R. B. Metz, S. E. Bradforth, and D. M. Neumark, Adv. Chem. Phys. 81, 1 (1992)]. The process may be described approximately in terms of a Franck-Condon type transfer of the vibrational wavefunction representing XLX{sup −}(00{sup 0}0) from the domain close to the minimum of its potential energy surface (PES) to the domain close to the linear transition state of the PES of the neutral XLX. As a consequence, prominent peaks of the photoelectron detachment spectra (pds) correlate with the vibrational energies E{sub XLX,vib} of states XLX(vib) which are centered at linear transition state. The corresponding vibrational quantum numbers may be labeled vib = (v{sub 1}v{sub 2}{sup l}v{sub 3}) = (00{sup 0}v{sub 3}). Accordingly, the related most prominent peaks in the pds are labeled v{sub 3}. We construct a model PES which mimics the “true” PES in the domain of transition state such that it supports vibrational states with energies E{sub XLX,pds,00{sup 0}v{sub 3}} close to the peaks of the pds labeled v{sub 3} = 0, 2, and 4. Subsequently, the same model PES is also used to calculate approximate values of the energies E{sub XMuX,00{sup 0}0} of the isotopomers XMuX(00{sup 0}0). For the heavy isotopomers XHX and XDX, it turns out that all energies E{sub XLX,00{sup 0}v{sub 3}} are above the threshold for dissociation, which means that all heavy XLX(00{sup 0}v{sub 3}) with wavefunctions centered at the transition state are unstable resonances with finite lifetimes. Turning the table, bound states of the heavy XLX are van

  3. Characterization and high cross-species transferability of microsatellite markers from the floral transcriptome of Aspidistra saxicola (Asparagaceae).

    PubMed

    Huang, Danni; Zhang, Yiqing; Jin, Mingda; Li, Hankun; Song, Zhiping; Wang, Yuguo; Chen, Jiakuan

    2014-05-01

    Recent studies utilizing transcriptome sequences generated by next-generation sequencing (NGS) technologies have demonstrated the ability to rapidly detect and characterize thousands of gene-based microsatellites from different plants. However, these simple sequence repeats (SSRs) were seldom used directly to test interspecific transferability in the populations of closely related species. Aspidistra Ker-Gawl. is a monocot genus with high species richness and diversity in flower structure, but its fresh floral materials are not easy to obtain. Until now, little is known about genetic background in the species of Aspidistra, quite apart from the fearful reduction of their natural habitats. In this study, the floral transcriptome of Aspidistra saxicola was obtained using NGS. Based on these data, a total of 5527 SSRs were identified in the unigenes. Among these SSRs, the proportions of di- and tri-nucleotide repeats were quite close (49.6% verse 46.8%), and the most tri-nucleotide repeats were AGG/CCT followed by AAG/CTT and AGC/GCT in A. saxicola, showing distinct differences with other angiosperm species. To assess genetic diversity in the species of Aspidistra, 48 SSR loci were tested in four available populations of A. elatior. The results revealed that more than a third of the loci were polymorphic. The majority of these primers could be amplified in 24 species representing the main clades of Aspidistra. The primer subsets from transcriptome data proved highly useful for detecting polymorphisms in the related species, supporting the finding that NGS is an efficient approach to molecular marker development at both intra- and interspecies levels, especially in endangered nonmodel species.

  4. Ancient DNA Analysis of 8000 B.C. Near Eastern Farmers Supports an Early Neolithic Pioneer Maritime Colonization of Mainland Europe through Cyprus and the Aegean Islands

    PubMed Central

    Fernández, Eva; Pérez-Pérez, Alejandro; Gamba, Cristina; Prats, Eva; Cuesta, Pedro; Anfruns, Josep; Molist, Miquel; Arroyo-Pardo, Eduardo; Turbón, Daniel

    2014-01-01

    The genetic impact associated to the Neolithic spread in Europe has been widely debated over the last 20 years. Within this context, ancient DNA studies have provided a more reliable picture by directly analyzing the protagonist populations at different regions in Europe. However, the lack of available data from the original Near Eastern farmers has limited the achieved conclusions, preventing the formulation of continental models of Neolithic expansion. Here we address this issue by presenting mitochondrial DNA data of the original Near-Eastern Neolithic communities with the aim of providing the adequate background for the interpretation of Neolithic genetic data from European samples. Sixty-three skeletons from the Pre Pottery Neolithic B (PPNB) sites of Tell Halula, Tell Ramad and Dja'de El Mughara dating between 8,700–6,600 cal. B.C. were analyzed, and 15 validated mitochondrial DNA profiles were recovered. In order to estimate the demographic contribution of the first farmers to both Central European and Western Mediterranean Neolithic cultures, haplotype and haplogroup diversities in the PPNB sample were compared using phylogeographic and population genetic analyses to available ancient DNA data from human remains belonging to the Linearbandkeramik-Alföldi Vonaldiszes Kerámia and Cardial/Epicardial cultures. We also searched for possible signatures of the original Neolithic expansion over the modern Near Eastern and South European genetic pools, and tried to infer possible routes of expansion by comparing the obtained results to a database of 60 modern populations from both regions. Comparisons performed among the 3 ancient datasets allowed us to identify K and N-derived mitochondrial DNA haplogroups as potential markers of the Neolithic expansion, whose genetic signature would have reached both the Iberian coasts and the Central European plain. Moreover, the observed genetic affinities between the PPNB samples and the modern populations of Cyprus and

  5. Increased tree establishment in Lithuanian peat bogs--insights from field and remotely sensed approaches.

    PubMed

    Edvardsson, Johannes; Šimanauskienė, Rasa; Taminskas, Julius; Baužienė, Ieva; Stoffel, Markus

    2015-02-01

    Over the past century an ongoing establishment of Scots pine (Pinus sylvestris L.), sometimes at accelerating rates, is noted at three studied Lithuanian peat bogs, namely Kerėplis, Rėkyva and Aukštumala, all representing different degrees of tree coverage and geographic settings. Present establishment rates seem to depend on tree density on the bog surface and are most significant at sparsely covered sites where about three-fourth of the trees have established since the mid-1990s, whereas the initial establishment in general was during the early to mid-19th century. Three methods were used to detect, compare and describe tree establishment: (1) tree counts in small plots, (2) dendrochronological dating of bog pine trees, and (3) interpretation of aerial photographs and historical maps of the study areas. In combination, the different approaches provide complimentary information but also weigh up each other's drawbacks. Tree counts in plots provided a reasonable overview of age class distributions and enabled capturing of the most recently established trees with ages less than 50 years. The dendrochronological analysis yielded accurate tree ages and a good temporal resolution of long-term changes. Tree establishment and spread interpreted from aerial photographs and historical maps provided a good overview of tree spread and total affected area. It also helped to verify the results obtained with the other methods and an upscaling of findings to the entire peat bogs. The ongoing spread of trees in predominantly undisturbed peat bogs is related to warmer and/or drier climatic conditions, and to a minor degree to land-use changes. Our results therefore provide valuable insights into vegetation changes in peat bogs, also with respect to bog response to ongoing and future climatic changes.

  6. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo

    PubMed Central

    Figueiredo, Carlos R.; Matsuo, Alisson L.; Pereira, Felipe V.; Rabaça, Aline N.; Farias, Camyla F.; Girola, Nátalia; Massaoka, Mariana H.; Azevedo, Ricardo A.; Scutti, Jorge A.B.; Arruda, Denise C.; Silva, Luciana P.; Rodrigues, Elaine G.; Lago, João Henrique G.; Travassos, Luiz R.; Silva, Regildo M.G.

    2014-01-01

    Background: Pyrostegia venusta (Ker. Gawl.) Miers (Bignoniacea) is a medicinal plant from the Brazilian Cerrado used to treat leucoderma and common diseases of the respiratory system. Objective: To investigate the antitumor activity of P.venusta extracts against melanoma. Materials and Methods: The cytotoxic activity and tumor induced cell death of heptane extract (HE) from P. venusta flowers was evaluated against murine melanoma B16F10-Nex2 cells in vitro and in a syngeneic model in vivo. Results: We found that HE induced apoptosis in melanoma cells by disruption of the mitochondrial membrane potential, induction of reactive oxygen species and late apoptosis evidenced by plasma membrane blebbing, cell shrinkage, chromatin condensation and DNA fragmentation, exposure of phosphatidylserine on the cell surface and activation of caspase-2,-3,-8,-9. HE was also protective against singeneyc subcutaneous melanoma HE compounds were also able to induce cell cycle arrest at G2/M phases on tumor cells. On fractionation of HE in silica gel we isolated a cytotoxic fraction that contained a mixture of saturated hydrocarbons identified by 1H NMR and GC-MS analyses. Predominant species were octacosane (C28H58-36%) and triacontane (C30H62-13%), which individually showed significant cytotoxic activity against murine melanoma B16F10-Nex2 cells in vitro and a very promising antitumor protection against subcutaneous melanoma in vivo. Conclusion: The results suggest that the components of the heptane extract, mainly octasane and triacontane, which showed antitumor properties in experimental melanoma upon regional administration, might also be therapeutic in human cancer, such as in the mostly epidermal and slowly invasive melanomas, such as acral lentiginous melanoma, as an adjuvant treatment to surgical excision. PMID:24991116

  7. Biochemical and Molecular Characterization of a Serine Keratinase from Brevibacillus brevis US575 with Promising Keratin-Biodegradation and Hide-Dehairing Activities

    PubMed Central

    Jaouadi, Nadia Zaraî; Rekik, Hatem; Badis, Abdelmalek; Trabelsi, Sahar; Belhoul, Mouna; Yahiaoui, Amina Benkiar; Aicha, Houda Ben; Toumi, Abdessatar; Bejar, Samir; Jaouadi, Bassem

    2013-01-01

    Dehairing is one of the highly polluting operations in the leather industry. The conventional lime-sulfide process used for dehairing produces large amounts of sulfide, which poses serious toxicity and disposal problems. This operation also involves hair destruction, a process that leads to increased chemical oxygen demand (COD), biological oxygen demand (BOD), and total suspended solid (TSS) loads in the effluent. With these concerns in mind, enzyme-assisted dehairing has often been proposed as an alternative method. The main enzyme preparations so far used involved keratinases. The present paper reports on the purification of an extracellular keratinase (KERUS) newly isolated from Brevibacillus brevis strain US575. Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/MS) analysis revealed that the purified enzyme was a monomer with a molecular mass of 29121.11 Da. The sequence of the 27 N-terminal residues of KERUS showed high homology with those of Bacillus keratinases. Optimal activity was achieved at pH 8 and 40°C. Its thermoactivity and thermostability were upgraded in the presence of 5 mM Ca2+. The enzyme was completely inhibited by phenylmethanesulfonyl fluoride (PMSF) and diiodopropyl fluorophosphates (DFP), which suggests that it belongs to the serine protease family. KERUS displayed higher levels of hydrolysis, substrate specificity, and catalytic efficiency than NUE 12 MG and KOROPON® MK EG keratinases. The enzyme also exhibited powerful keratinolytic activity that made it able to accomplish the entire feather-biodegradation process on its own. The kerUS gene encoding KERUS was cloned, sequenced, and expressed in Escherichia coli. The biochemical properties of the extracellular purified recombinant enzyme (rKERUS) were similar to those of native KERUS. Overall, the findings provide strong support for the potential candidacy of this enzyme as an effective and eco-friendly alternative to the conventional chemicals used

  8. Increased tree establishment in Lithuanian peat bogs--insights from field and remotely sensed approaches.

    PubMed

    Edvardsson, Johannes; Šimanauskienė, Rasa; Taminskas, Julius; Baužienė, Ieva; Stoffel, Markus

    2015-02-01

    Over the past century an ongoing establishment of Scots pine (Pinus sylvestris L.), sometimes at accelerating rates, is noted at three studied Lithuanian peat bogs, namely Kerėplis, Rėkyva and Aukštumala, all representing different degrees of tree coverage and geographic settings. Present establishment rates seem to depend on tree density on the bog surface and are most significant at sparsely covered sites where about three-fourth of the trees have established since the mid-1990s, whereas the initial establishment in general was during the early to mid-19th century. Three methods were used to detect, compare and describe tree establishment: (1) tree counts in small plots, (2) dendrochronological dating of bog pine trees, and (3) interpretation of aerial photographs and historical maps of the study areas. In combination, the different approaches provide complimentary information but also weigh up each other's drawbacks. Tree counts in plots provided a reasonable overview of age class distributions and enabled capturing of the most recently established trees with ages less than 50 years. The dendrochronological analysis yielded accurate tree ages and a good temporal resolution of long-term changes. Tree establishment and spread interpreted from aerial photographs and historical maps provided a good overview of tree spread and total affected area. It also helped to verify the results obtained with the other methods and an upscaling of findings to the entire peat bogs. The ongoing spread of trees in predominantly undisturbed peat bogs is related to warmer and/or drier climatic conditions, and to a minor degree to land-use changes. Our results therefore provide valuable insights into vegetation changes in peat bogs, also with respect to bog response to ongoing and future climatic changes. PMID:25310886

  9. High-resolution rainfall estimation for Helsinki urban area using Helsinki radar network

    NASA Astrophysics Data System (ADS)

    Rojas, Laura; Nordling, Kalle; Cremonini, Roberto; Moisseev, Dmitri; Chandrasekar, Venkatachalam

    2014-05-01

    High resolution precipitation data is a crucial factor for hydrological applications in urban areas. Small fluctuations in precipitation fields are of great importance considering the fast response of urban catchments due to the dominance of impervious surfaces. High resolution precipitation observations are needed in order to characterize these fluctuations. Weather radar provides high spatial resolution precipitation estimations. However, the quality of its observations in an urban environment is significantly degraded, among other things, by ground clutter and beam-blockage. A solution for this problem is to use a radar network, where the data gaps of one radar will be filled by using observations from the others. Very few cities have dedicated weather radar networks. In some cities, like Helsinki, there are several weather radars covering the metropolitan area, but they are operated by different organizations. In this study, we show how such systems can be used to build a network and what is the advantage of using radarnetworks for estimating precipitation in urban catchments. The urban Helsinki area is covered by observations from three individual-purpose C-band weather radars (Helsinki University's Kumpula (KUM), Vaisala Oy's Kerava (KER) and Finnish Meteorological Institute's Vantaa (VAN)). We used the data from these radars to form a network and we design a similar task which runs at the same time in each radar couple of times per day. Nonetheless, it is challenging to make them observe at the same area at exactly the same time, which could lead to fast changing, short precipitation events being missed. Hence, synchronization and temporal resolution are the main concerns when building a network. Consequently, to decrease the impact of these restrictions in the Helsinki radar network we propose the use of the optic flow interpolation algorithm to retrieve information in between two radar observations and use the retrieved dataset from the three radars to

  10. Biochemical and molecular characterization of a serine keratinase from Brevibacillus brevis US575 with promising keratin-biodegradation and hide-dehairing activities.

    PubMed

    Jaouadi, Nadia Zaraî; Rekik, Hatem; Badis, Abdelmalek; Trabelsi, Sahar; Belhoul, Mouna; Yahiaoui, Amina Benkiar; Ben Aicha, Houda; Toumi, Abdessatar; Bejar, Samir; Jaouadi, Bassem

    2013-01-01

    Dehairing is one of the highly polluting operations in the leather industry. The conventional lime-sulfide process used for dehairing produces large amounts of sulfide, which poses serious toxicity and disposal problems. This operation also involves hair destruction, a process that leads to increased chemical oxygen demand (COD), biological oxygen demand (BOD), and total suspended solid (TSS) loads in the effluent. With these concerns in mind, enzyme-assisted dehairing has often been proposed as an alternative method. The main enzyme preparations so far used involved keratinases. The present paper reports on the purification of an extracellular keratinase (KERUS) newly isolated from Brevibacillus brevis strain US575. Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/MS) analysis revealed that the purified enzyme was a monomer with a molecular mass of 29121.11 Da. The sequence of the 27 N-terminal residues of KERUS showed high homology with those of Bacillus keratinases. Optimal activity was achieved at pH 8 and 40°C. Its thermoactivity and thermostability were upgraded in the presence of 5 mM Ca(2+). The enzyme was completely inhibited by phenylmethanesulfonyl fluoride (PMSF) and diiodopropyl fluorophosphates (DFP), which suggests that it belongs to the serine protease family. KERUS displayed higher levels of hydrolysis, substrate specificity, and catalytic efficiency than NUE 12 MG and KOROPON® MK EG keratinases. The enzyme also exhibited powerful keratinolytic activity that made it able to accomplish the entire feather-biodegradation process on its own. The kerUS gene encoding KERUS was cloned, sequenced, and expressed in Escherichia coli. The biochemical properties of the extracellular purified recombinant enzyme (rKERUS) were similar to those of native KERUS. Overall, the findings provide strong support for the potential candidacy of this enzyme as an effective and eco-friendly alternative to the conventional chemicals

  11. Neurofilaments and NFL-TBS.40-63 peptide penetrate oligodendrocytes through clathrin-dependent endocytosis to promote their growth and survival in vitro.

    PubMed

    Fressinaud, C; Eyer, J

    2015-07-01

    Neurofilaments (NF) are released into the cerebrospinal fluid (CSF) during multiple sclerosis (MS), but their role outside the axon is still unknown. In vitro NF fractions, as well as tubulin (TUB), increase oligodendrocyte (OL) progenitor proliferation and/or their differentiation depending on the stage of their purification (Fressinaud et al., 2012). However the mechanism by which NF enter these cells, as well as that of synthetic peptides displaying NFL-tubulin-binding site (NFL-TBS.40-63) (Fressinaud and Eyer, 2014), remains elusive. Using rat OL secondary cultures we localized NF, TUB, and NFL-TBS.40-63 by double immunocytochemistry and confocal microscopy. After treating OL cultures with NF P2 (2nd pellet of the purification), or TRITC-TUB, these proteins were localized in the cytoplasmic processes of myelin basic protein (MBP+) expressing OL. Similarly biotinylated NFL-TBS.40-63 synthetic peptides and KER-TBS.1-24 were detected in OL progenitors, differentiated (CNP+) and MBP+ OL. In addition, NFL-TBS.40-63 colocalized with cholera toxin, a known marker of endocytosis, within the cells. Pretreatment of OL by methyl β cyclodextrin abolishes both cholera toxin and NFL-TBS.40-63 uptake, indicating endocytosis. Clathrin-dependent endocytosis was further confirmed by treatment with dynasore, a dynamin inhibitor, which inhibited the uptake of peptides, as well as NFP2 fractions, by 50%. This study demonstrates that axon cytoskeletal proteins and peptides can be internalized by OL through endocytosis. This process could be involved during demyelination, and the release of axon proteins might promote remyelination.

  12. Natural infection in anopheline species and its implications for autochthonous malaria in the Atlantic forest in Brazil

    PubMed Central

    2013-01-01

    Background A descriptive study was carried out in an area of the Atlantic Forest with autochthonous malaria in the Parelheiros subdistrict on the periphery of the municipality of São Paulo to identify anopheline fauna and anophelines naturally infected with Plasmodium as well as to discuss their role in this peculiar epidemiological context. Methods Entomological captures were made from May 2009 to April 2011 using Shannon traps and automatic CDC traps in four areas chosen for their different patterns of human presence and incidences of malaria (anthropic zone 1, anthropic zone 2, transition zone and sylvatic zone). Natural Plasmodium infection was detected by nested PCR based on amplification of the 18S rRNA gene. Results In total, 6,073 anophelines were collected from May 2009 to April 2011, and six species were identified in the four zones. Anopheles cruzii was the predominant species in the three environments but was more abundant in the sylvatic zone. Anopheles (Kerteszia) cruzii specimens from the anthropic and sylvatic zones were positive for P. vivax and P. malariae. An. (Ker.) bellator, An. (Nys.) triannulatus, An. (Nys.) strodei, An. (Nys.) lutzi and An. (Ano) maculipes were found in small numbers. Of these, An. (Nys.) triannulatus and An. (Nys.) lutzi, which were collected in the anthropic zone, were naturally infected with P. vivax while An. (Nys.) triannulatus from the anthropic zones and An. (Nys.) strodei from the transition zone were positive for P. malariae. Conclusion These results confirm that Anopheles (Kerteszia) cruzii plays an important role as a major Plasmodium vector. However, the finding of other naturally infected species may indicate that secondary vectors are also involved in the transmission of malaria in the study areas. These findings can be expected to help in the implementation of new measures to control autochthonous malaria in areas of the Atlantic Forest. PMID:23497493

  13. Ancient DNA analysis of 8000 B.C. near eastern farmers supports an early neolithic pioneer maritime colonization of Mainland Europe through Cyprus and the Aegean Islands.

    PubMed

    Fernández, Eva; Pérez-Pérez, Alejandro; Gamba, Cristina; Prats, Eva; Cuesta, Pedro; Anfruns, Josep; Molist, Miquel; Arroyo-Pardo, Eduardo; Turbón, Daniel

    2014-06-01

    The genetic impact associated to the Neolithic spread in Europe has been widely debated over the last 20 years. Within this context, ancient DNA studies have provided a more reliable picture by directly analyzing the protagonist populations at different regions in Europe. However, the lack of available data from the original Near Eastern farmers has limited the achieved conclusions, preventing the formulation of continental models of Neolithic expansion. Here we address this issue by presenting mitochondrial DNA data of the original Near-Eastern Neolithic communities with the aim of providing the adequate background for the interpretation of Neolithic genetic data from European samples. Sixty-three skeletons from the Pre Pottery Neolithic B (PPNB) sites of Tell Halula, Tell Ramad and Dja'de El Mughara dating between 8,700-6,600 cal. B.C. were analyzed, and 15 validated mitochondrial DNA profiles were recovered. In order to estimate the demographic contribution of the first farmers to both Central European and Western Mediterranean Neolithic cultures, haplotype and haplogroup diversities in the PPNB sample were compared using phylogeographic and population genetic analyses to available ancient DNA data from human remains belonging to the Linearbandkeramik-Alföldi Vonaldiszes Kerámia and Cardial/Epicardial cultures. We also searched for possible signatures of the original Neolithic expansion over the modern Near Eastern and South European genetic pools, and tried to infer possible routes of expansion by comparing the obtained results to a database of 60 modern populations from both regions. Comparisons performed among the 3 ancient datasets allowed us to identify K and N-derived mitochondrial DNA haplogroups as potential markers of the Neolithic expansion, whose genetic signature would have reached both the Iberian coasts and the Central European plain. Moreover, the observed genetic affinities between the PPNB samples and the modern populations of Cyprus and Crete

  14. Mapping the emotional landscape: The role of specific emotions in conceptual categorization.

    PubMed

    Zhu, Nan; Cai, Yong-hua; Sun, Fa-wei; Yang-yang, Yi-fan

    2015-07-01

    Although researchers generally subscribe to the opinion that emotions play a critical role in cognition, very few (see Niedenthal, Halberstadt, & Innes-Ker, 1999) have examined the specific interaction between the emotional state of the perceiver and the emotional meaning of stimuli in conceptual categorization - an important aspect of "higher-level" cognition. Niedenthal et al. (1999) advanced a fine-grained theory of emotional response categorization, arguing that emotional states increase the tendency to categorize concepts into a predictable set of emotional response categories characterized by the common, distinct emotional responses elicited by the concepts. Based on the pioneering work of Niedenthal et al., we further argued that (1) the specific emotion experienced by the individual should selectively facilitate the categorization of concepts associated with the same emotion, (2) both in terms of category inclusion and category exclusion, and (3) this facilitation effect should not be contingent on the awareness of the emotional state. In three experiments, participants were induced to experience different emotional states through movies or a facial-feedback manipulation. They judged whether or not a target concept belonged to the same category as the two comparison concepts. Some of the concept triads shared emotional associations, while others didn't. Results showed that emotive participants had a greater tendency than those in a neutral mood to group concepts according to their emotional associations, and to distinguish concepts with different emotional associations. They were also more efficient in categorizing concepts that had specific emotional meaning corresponding to their own emotional state than to other emotional concepts. Furthermore, participants posing a disgust expression without their knowledge showed higher tendency to categorize concepts according to their relevance to disgust. Implications and potential applications of the findings were

  15. [Lipid-lowering therapy and patient adherence in the MULTI GAP 2013 trial].

    PubMed

    Simonyi, Gábor

    2014-04-27

    Bevezetés: A dyslipidaemia ismert cardiovascularis kockázati tényező. A lipidterápiában a célértékek elérésének fontos tényezője a megfelelő betegadherencia. Célkitűzés: A MULTI GAP (MULTI Goal Attainment Problem) 2013-as vizsgálatban atheroscleroticus betegségben szenvedő betegek esetében a statinterápia adherenciájának és perzisztenciájának felmérése, amely részben a vizsgálatban részt vevő orvosok becslésén, illetve 319, a megelőző évben elvégzett MULTI GAP vizsgálatban részt vett beteg esetében az Országos Egészségbiztosítási Pénztár vénykiváltási adatbázisán alapult. Módszer: A MULTI GAP 2013 vizsgálatban standard, strukturált kérdőívek segítségével 1519 beteg adatai kerültek feldolgozásra. Az elemzésben kiértékelésre kerültek az egyes ellátási szinteken elért lipidértékek, a kezelőorvos által vélt betegadherencia, a 319 beteg Országos Egészségbiztosítási Pénztár vénykiváltási adataira támaszkodó valós adherencia, a kezelőorvosok elégedettsége a statinterápia eredményeivel, illetve az adherencia és a lipideredmények összevetése. Eredmények: Az elmúlt 7 év felméréseinek adatait is figyelembe véve előtérbe kerültek a hatékonyabb statinok; az atorvastatin és rozuvastatin alkalmazásának összesített aránya 49%-ról 83%-ra, azaz mintegy 70%-kal nőtt. A betegadherencia vonatkozásában kimutatták, hogy a 2,5 mmol/l alatti LDL-koleszterin-értékeket elért betegeknél az 1 év alatt kiváltott receptek száma mintegy nyolc gyógyszertári beváltást jelentett. Ehhez képest a 2,5 mmol/l feletti LDL-koleszterin-értékű csoportban a gyógyszerkiváltás lényegesen alacsonyabb volt (5,3 és 6,3 közötti). Éves szinten a 10–12 és a 7–9 gyógyszerkiváltás szignifikánsan alacsonyabb LDL-koleszterin-szintet jelentett a semennyit (0), illetve az 1–3 receptet éves szinten kiváltók csoportjaihoz képest. A kezelőorvosok által 100%-os

  16. The Physicist and Astronomer Christoper Scheiner - Biography Letters, Works

    NASA Astrophysics Data System (ADS)

    Daxecker, Franz

    The Jesuit priest Christopher Scheiner was one of the most influential astronomers of the first half of the 17th century. He was a creative and down-to-earth natural scientist who worked in the fields of astronomy, physics, optics and ophthalmology, while following his vocations as university lecturer, church builder and pastor. In scientific matters he was Galilei's opponent. Their dispute centred on the priority of discovery in regard to the sunspots. Scheiner was not the first to discover the sunspots, but he gave the most detailed account thereofin his main work "Rosa Ursina sive Sol". He was, however, ceaseless in his defense of the geocentric system. In 1891, Anton v.Braunmühl published a biography of Father Scheiner. Ever since then, new documents have come to light, justifying the publication of a new biography. Among the documents now available is Scheiner's hitherto unknown dissertation. Notes taken during his lectures in Ingolstadt provide valuable information on astronomy using the telescope, an invention of his lifetime. His exchange of letters with personalities like Archduke Leopold V of Austria-Tyrol, with scientists like Magini, Galilei, Gassendi, Kepler and confriars Rader, Guldin, Alber, Minutuli, Cysat und Kircher is a source of precious insights. Letters to Scheiner from the Father Generals of his order display evidence of his superiors' zero tolerance for the helincentric system. They also disclose Scheiner's wish to become a missionary in China, the financial difficulties he faced while trying to find a publisher for his "Rosa Ursina sive Sol" and his personal shortcomings. A Scheiner obituary from 1650 was found in Cracow in 2001. It contains information on the troublesome last years of his life and has finally allowed us to determine the year of his birth. Scheiner's personality has been praised as well as criticized by many authors - sometimes depending on their ideological backgrounds. This holds true especially regarding the argument

  17. NVP melt/magma viscosity: insight on Mercury lava flows

    NASA Astrophysics Data System (ADS)

    Rossi, Stefano; Morgavi, Daniele; Namur, Olivier; Vetere, Francesco; Perugini, Diego; Mancinelli, Paolo; Pauselli, Cristina

    2016-04-01

    After more than four years of orbiting Mercury, NASA's MESSENGER spacecraft came to an end in late April 2015. MESSENGER has provided many new and surprising results. This session will again highlight the latest results on Mercury based on MESSENGER observations or updated modelling. The session will further address instrument calibration and science performance both retrospective on MESSENGER and on the ESA/JAXA BepiColombo mission. Papers covering additional themes related to Mercury are also welcomed. Please be aware that this session will be held as a PICO session. This will allow an intensive exchange of expertise and experience between the individual instruments and mission. NVP melt/magma viscosity: insight on Mercury lava flows S. Rossi1, D. Morgavi1, O. Namur2, D. Perugini1, F.Vetere1, P. Mancinelli1 and C. Pauselli1 1 Dipartimento di Fisica e Geologia, Università di Perugia, piazza Università 1, 06123 Perugia, Italy 2 Uni Hannover Institut für Mineralogie, Leibniz Universität Hannover, Callinstraβe 3, 30167 Hannover, Germany In this contribution we report new measurements of viscosity of synthetic komatitic melts, used the behaviour of silicate melts erupted at the surface of Mercury. Composition of Mercurian surface magmas was calculated using the most recent maps produced from MESSENGER XRS data (Weider et al., 2015). We focused on the northern hemisphere (Northern Volcanic Province, NVP, the largest lava flow on Mercury and possibly in the Solar System) for which the spatial resolution of MESSENGER measurements is high and individual maps of Mg/Si, Ca/Si, Al/Si and S/Si were combined. The experimental starting material contains high Na2O content (≈7 wt.%) that strongly influences viscosity. High temperature viscosity measurements were carried out at 1 atm using a concentric cylinder apparatus equipped with an Anton Paar RheolabQC viscometer head at the Department of Physics and Geology (PVRG_lab) at the University of Perugia (Perugia, Italy

  18. Polymerase chain reaction: basic protocol plus troubleshooting and optimization strategies.

    PubMed

    Lorenz, Todd C

    2012-01-01

    In the biological sciences there have been technological advances that catapult the discipline into golden ages of discovery. For example, the field of microbiology was transformed with the advent of Anton van Leeuwenhoek's microscope, which allowed scientists to visualize prokaryotes for the first time. The development of the polymerase chain reaction (PCR) is one of those innovations that changed the course of molecular science with its impact spanning countless subdisciplines in biology. The theoretical process was outlined by Keppe and coworkers in 1971; however, it was another 14 years until the complete PCR procedure was described and experimentally applied by Kary Mullis while at Cetus Corporation in 1985. Automation and refinement of this technique progressed with the introduction of a thermal stable DNA polymerase from the bacterium Thermus aquaticus, consequently the name Taq DNA polymerase. PCR is a powerful amplification technique that can generate an ample supply of a specific segment of DNA (i.e., an amplicon) from only a small amount of starting material (i.e., DNA template or target sequence). While straightforward and generally trouble-free, there are pitfalls that complicate the reaction producing spurious results. When PCR fails it can lead to many non-specific DNA products of varying sizes that appear as a ladder or smear of bands on agarose gels. Sometimes no products form at all. Another potential problem occurs when mutations are unintentionally introduced in the amplicons, resulting in a heterogeneous population of PCR products. PCR failures can become frustrating unless patience and careful troubleshooting are employed to sort out and solve the problem(s). This protocol outlines the basic principles of PCR, provides a methodology that will result in amplification of most target sequences, and presents strategies for optimizing a reaction. By following this PCR guide, students should be able to: • Set up reactions and thermal cycling

  19. [Mental disease in two classical music composers].

    PubMed

    Rempelakos, L; Poulakou-Rebelakou, E; Ploumpidis, D

    2012-01-01

    A study οn two neglected classical music composers suffering a not syphilitic mental disease, is attempted here, syphilis of the central nervous system being frequent in that time. A brief overview on the psychiatric ailments of many great composers reveals suicide attempts and more or less severe depression following external events. The issue of a possible relationship between mental disease and (musical) creativity can be discussed, as mood swings and a certain tendency to melancholia are frequent features of a talented brain (a fact that can also be detected in their works). The first case presented here is Hans Rott from Austria, the beloved student of Anton Bruckner, who was considered to be at least equal to his famous classmate Gustav Mahler. The great expectations of his teacher and his friends suddenly came to an end, when he suffered a crisis of schizophrenia and was hospitalized in an insane asylum in Lower Austria. The tragic psychiatric adventure of the young musician lasted almost four years. He was diagnosed as a case of "hallucinatory insanity" and "persecution mania" by the medical staff, before dying of tuberculosis, aged only 26, and having completed only one symphony and several smaller works. His name came again on surface only a century after his death, when in 1989 his Symphony in E Major was discovered and premiered with great success, permitting to its creator a posthumous recognition, among Bruckner and Mahler. The second case of mental illness is that of the Armenian Komitas Vardapet. He was an orphan who grew up in theological schools and became a monk and later a priest, though he spent some years in Berlin in order to develop his musical skills. He is considered to be an authority of Armenian ecclesiastic music, introducing polyphony in the Armenian Church's music and collecting numerous traditional songs from all parts of Armenia. In 1915, during the Armenian genocide he was deported, tortured but finally saved, due to interventions

  20. Music and the Nature: Input of the Czech Composers

    NASA Astrophysics Data System (ADS)

    Nemec, Vaclav; Nemcova, Lidmila

    2014-05-01

    Extraordinary occasions for art of any kind - music, creative graphic and plastic arts, literature (classic, modern incl. science fiction), theatre, cinema, etc. - exist to harmonise individual personal interests with those of the humanity well-being and of the Nature and also to cultivate individual spirituality and the appropriate values. Arts can be applied as irreplaceable means for making any human being better, for improving his sense for solidarity and for increasing his ethical sensibility. An interest for the art should be cultivated already since the childhood. - How much of inspiration for numerous composers all over the world has been given by the Nature, how much of inspiration for people who by listening to such a music are increasing nobility of their behaviour as well as their friendly approach to the Nature. - Many classical music works have been written with a strong inspiration by the Nature itself from the past until today. The actual Year of the Czech Music gives the possibility to present the most famous Czech composers inspired by the Nature (selected examples only): Bedřich Smetana (1824 - 1884): At the sea shore - a concert etude for piano inspired by his stay in Göteborg (Sweden); Vltava (Moldau) - a symphonic poem from the cycle "My country" inspired by the river crossing Bohemia from the South to Prague; From the Bohemian woods and meadows - another symphonic poem from the same cycle. Antonín Dvořák (1841 - 1904): V přírodě (In the Nature) - a work for orchestra Leoš Janáček (1854 - 1928): Příhody li\\vsky Bystrou\\vsky (The Cunning Little Vixen) - an opera situated mostly in a forest. Josef Bohuslav Foerster (1859-1951): Velké širé rodné lány (Big large native fields) - a choir for men singers inspired by the nature in the region where the composer as a boy from Prague was visiting his grand-father. Vítězslav Novák (1870 - 1949): In Tatra mountains - a symphonic poem expressing the author's passion for the famous

  1. [Mental disease in two classical music composers].

    PubMed

    Rempelakos, L; Poulakou-Rebelakou, E; Ploumpidis, D

    2012-01-01

    A study οn two neglected classical music composers suffering a not syphilitic mental disease, is attempted here, syphilis of the central nervous system being frequent in that time. A brief overview on the psychiatric ailments of many great composers reveals suicide attempts and more or less severe depression following external events. The issue of a possible relationship between mental disease and (musical) creativity can be discussed, as mood swings and a certain tendency to melancholia are frequent features of a talented brain (a fact that can also be detected in their works). The first case presented here is Hans Rott from Austria, the beloved student of Anton Bruckner, who was considered to be at least equal to his famous classmate Gustav Mahler. The great expectations of his teacher and his friends suddenly came to an end, when he suffered a crisis of schizophrenia and was hospitalized in an insane asylum in Lower Austria. The tragic psychiatric adventure of the young musician lasted almost four years. He was diagnosed as a case of "hallucinatory insanity" and "persecution mania" by the medical staff, before dying of tuberculosis, aged only 26, and having completed only one symphony and several smaller works. His name came again on surface only a century after his death, when in 1989 his Symphony in E Major was discovered and premiered with great success, permitting to its creator a posthumous recognition, among Bruckner and Mahler. The second case of mental illness is that of the Armenian Komitas Vardapet. He was an orphan who grew up in theological schools and became a monk and later a priest, though he spent some years in Berlin in order to develop his musical skills. He is considered to be an authority of Armenian ecclesiastic music, introducing polyphony in the Armenian Church's music and collecting numerous traditional songs from all parts of Armenia. In 1915, during the Armenian genocide he was deported, tortured but finally saved, due to interventions

  2. VizieR Online Data Catalog: The Initial Gaia Source List (IGSL) (Smart, 2013)

    NASA Astrophysics Data System (ADS)

    Smart, R. L.; Nicastro, L.

    2013-11-01

    The IGSL is a compilation catalog produced for the Gaia mission. We have combined data from the following catalogs or datasets to produce a homogenous list of positons, proper motions, photometry in a blue and red band and estimates of the magnitudes in the Gaia G and G_RVS bands. Included Catalogs: Tycho2, LQRF, UCAC4, SDSS-DR9, PPMXL, GSC23, GEPC, OGLE, Sky2000, 2MASS. Note that in compiling the various entries we did not consider the individual flags. Overall, we think this catalog is reliable but there will be errors, mismatches and duplicates. The user should use this catalog with that in mind, it is fine for statistical studies that has some way to remove obviously incorrect entries but it should only be used with care for individual objects. The source catalogs used to produce the IGSL are: * The Gaia Ecliptic Pole Catalog, version 3.0 (GEPC) Altmann & Bastian 2009, "Ecliptic Poles Catalogue Version 1.1" ESA Document GAIA-C3-TN-ARI-MA-002 URL http://www.rssd.esa.int/llink/livelink/open/2885828 * GSC2.3: GSC2 version 2.3, Lasker et al. 2008AJ....136..735L (I/305) * an excerpt of the 4th version of the Gaia Initial QSO Catalog (GIQC) as compiled by the GWP-S-335-13000, formed by Alexandre H. Andrei, Christophe Barache, Dario N. da Silva Neto, Francois Taris, Geraldine Bourda, Jean-Francois Le Campion, Jean Souchay, J.J. Pereira Osorio, Julio I. Bueno de Camargo, Marcelo Assafin, Roberto Vieira Martins, Sebastien Bouquillon, Sebastien Lambert, Sonia Anton, Patrick Charlot * OGLE: Optical Gravitational Lensing Experiment version III (Szymaski et al., 2011, Cat. J/AcA/61/83) * PPMXL: Positions and Proper Motions "Extra Large" Catalog, Roeser et al. (2010, Cat. I/317) * SDSS: Sloan Digital Sky Survey data release 9, Cat. V/139 * UCAC4: Zacharias et al., 2012, Cat. I/322 * Tycho-2, Hoeg et al., 2000, Cat. I/259 (1 data file).

  3. Network representation of conformational transitions between hidden intermediates of Rd-apocytochrome b562

    PubMed Central

    Duan, Mojie; Liu, Hanzhong; Li, Minghai; Huo, Shuanghong

    2015-01-01

    The folding kinetics of Rd-apocytochrome b562 is two-state, but native-state hydrogen exchange experiments show that there are discrete partially unfolded (PUF) structures in equilibrium with the native state. These PUF structures are called hidden intermediates because they are not detected in kinetic experiments and they exist after the rate-limiting step. Structures of the mimics of hidden intermediates of Rd-apocytochrome b562 are resolved by NMR. Based upon their relative stability and structural features, the folding mechanism was proposed to follow a specific pathway (unfolded → rate-limiting transition state → PUF1 → PUF2 → native). Investigating the roles of equilibrium PUF structures in folding kinetics and their interrelationship not only deepens our understanding of the details of folding mechanism but also provides guides in protein design and prevention of misfolding. We performed molecular dynamics simulations starting from a hidden intermediate and the native state of Rd-apocytochrome b562 in explicit solvent, for a total of 37.18 μs mainly with Anton. We validated our simulations by detailed comparison with experimental data and other computations. We have verified that we sampled the post rate-limiting transition state region only. Markov state model was used to analyze the simulation results. We replace the specific pathway model with a network model. Transition-path theory was employed to calculate the net effective flux from the most unfolded state towards the most folded state in the network. The proposed sequential folding pathway via PUF1 then more stable, more native-like PUF2 is one of the routes in our network, but it is not dominant. The dominant path visits PUF2 without going through PUF1. There is also a route from PUF1 directly to the most folded state in the network without visiting PUF2. Our results indicate that the PUF states are not necessarily sequential in the folding. The major routes predicted in our network are

  4. Temporal Variability of Methane Flares on the Cascadia Margin Imaged with Swath Bathymetric Data (Ancillary Data to Cascadia Initiative Cruise AT26-02)

    NASA Astrophysics Data System (ADS)

    Trehu, A. M.

    2013-12-01

    Livelybrooks (Un. of Oregon), undergraduates participating in summer research programs at (Elizabeth Davis, Indiana Un. and Oregon State Un. REU program in Oceanography; David Clemens-Sewall, Dartmouth College and IRIS intern), community college students and faculty (Haley Domer, Portland CC; Jonas Cervantes and Greg Mulder, Linn-Benton CC), and graduate students and scientists who had applied to sailed on a Cascadia Initiative cruise (Bridget Hass, Oregon State Un.; Katherine Kirk, Cornell Un. and WHOI; Anton Ypma, Western Washington Un.; Lexi Black, CA State Un. Northridge; Samantha Black, College of Charleston). WHOI marine technician Rob Hagg and MATE Intern Arianna Johns also contributed significantly to this effort.

  5. Volumetric Properties of Dilute Aqueous Solutions of 1- and 2-propanol to 50 MPa and 373.15 K

    NASA Astrophysics Data System (ADS)

    Seitz, J.; Bahramian, J.; Blackwell, R.; Inaki, T.; York, D.; Schulte, M. D.

    2014-12-01

    The need to accurately model and understand reactions among organic compounds and biomolecules in solution is necessary to develop realistic chemical models for the reactions leading to the emergence of life and metabolic processes of extremophiles under elevated temperature and pressure conditions. Unfortunately, the scarcity of experimentally determined volumetric (and other) properties for important compounds at high temperatures and pressures leads to uncertainty in the calculation of reaction properties. Experimentally determined volumetric properties of aqueous solutions at non-standard conditions provide direct tests of current estimation methods and aid in the refinement of these methods. The goal of our research is to provide a database of experimentally determined volumetric properties. In previous studies, we have examined important organic molecules and biomolecules such as adenosine, coenzyme M and D-ribose. In this study, we investigate the volumetric properties of the structural isomers 1- and 2-propanol. 1-propanol (n-propanol) is a primary alcohol (CH3CH2CH2OH) and 2-propanol (isopropanol) is the simplest example of a secondary alcohol (CH3CHOHCH3). These compounds differ slightly in structure depending on to which carbon atom the hydroxyl group is bonded and will provide a sensitive test of current estimation methods and lead to more accurate predictions of the properties of complex aqueous systems at elevated temperatures and pressures. We obtained the densities of aqueous solutions of the alchohols using an Anton Paar DMA HP vibrating tube densimeter. Pressure was measured (pressure transducer) to an accuracy of ±0.01% and temperature was measured (integrated platinum thermometer) with an accuracy of ±0.05 K. Experimental uncertainty of density measurements is less than ±0.0001 g·cm-3. The partial molar volumes at infinite dilution (V∞) for 1- and 2-propanol were calculated from the measured densities and are shown in the figure at 0

  6. Relating rheological measurements to primary and secondary skin feeling when mineral-based and Fischer-Tropsch wax-based cosmetic emulsions and jellies are applied to the skin.

    PubMed

    Bekker, M; Webber, G V; Louw, N R

    2013-08-01

    Rheology measurements were correlated to skin sensations occurring when cream and petroleum jelly cosmetic products containing different amounts of synthetic Fischer-Tropsch wax were applied to the skin. A panel of 15 people with a background in cosmetic product development were asked to rate skin feelings when a range of petroleum jelly and cream samples are applied to the skin. Primary skin feel, or the spreadability of a cosmetic product, was correlated to the product's flow onset and maximum viscosity as measured by a Anton Paar rheometer, whereas secondary skin feel or the sensation occurring at the end of application when the product was completely rubbed into the skin was correlated to the product's viscosity measured at high shear rates. The cream samples prepared with a petroleum jelly containing 10% and 20% Fischer-Tropsch wax fell within the boundary of good primary skin feeling of cream products. Predominantly, synthetic petroleum jellies were given the best assessments in terms of primary skin feeling and were used with mineral-based petroleum jellies to determine the boundary of good primary skin feeling for petroleum jelly products. The further away a product falls from this rheological boundary the poorer the skin feeling assessment appears to be by the panel. Products containing Fischer-Tropsch waxes were given the best assessment by the panel for secondary skin feeling. Comments from the panel include that these products feel silky and light on the skin. The higher the Fischer-Tropsch wax content, the lower viscosity was at high shear rate (ϒ = 500 s(-1) ) and the higher the assessment by the panel. Rheological measurements can be used to objectively determine skin sensation when products are applied to the skin; this may shorten research and development times. A rheology boundary of certain product viscosity and shear stress applied is associated with good primary skin feeling for lotions, creams and petroleum jellies. Lower product viscosity

  7. Local Heroes Live!

    NASA Astrophysics Data System (ADS)

    1999-09-01

    Physics teacher Andrew Morrison from High Pavement College in Nottingham has recently been appointed as Schools' officer for particle physics by the Particle Physics and Astronomy Research Council, as part of the Council's Public Understanding of Science programme. As well as his role as an experienced physics teacher, Andrew has acted as marketing manager for his college and chair of the Nottinghamshire section of the Association for Science Education. He will now be working two days each week in his new role with PPARC, acting as a link between the science education and research communities, helping researchers develop ideas for promoting particle physics and leading some specific new projects for the production of schools materials. Andrew can be contacted at High Pavement Sixth Form College, Gainsford Crescent, Nottingham NG5 5HT (tel: 0115 916 6165 or e-mail: morrison@innotts.co.uk). On the other side of the Atlantic, an 18 year-old student at Atlee High School in Mechanicsville, Virginia, USA was the recipient of the `1999 Young Scientist of the Year' award. Jakob Harmon submitted a project on magnetic levitation (maglev) in this extracurricular competition organized by PhysLINK.com, a leading Internet authority on physics and engineering education. The prize was a summer placement at Virginia Polytechnic Institute, Blacksburg, where Jakob continued his education in one of the most active maglev research and development groups in the USA. He also received science books and software as part of the award. The PhysLINK.com award was established to recognize, encourage and foster talented high school students in physics and engineering, with the prize being designed to fit the specific needs and aspirations of each individual winner. Details of next year's competition, along with Jakob's project and more about magnetic levitation can be viewed at www.physlink.com or by contacting Anton Skorucak of PhysLINK.com at 11271 Ventura Blvd #299, Studio City, CA 91606

  8. Relating rheological measurements to primary and secondary skin feeling when mineral-based and Fischer-Tropsch wax-based cosmetic emulsions and jellies are applied to the skin.

    PubMed

    Bekker, M; Webber, G V; Louw, N R

    2013-08-01

    Rheology measurements were correlated to skin sensations occurring when cream and petroleum jelly cosmetic products containing different amounts of synthetic Fischer-Tropsch wax were applied to the skin. A panel of 15 people with a background in cosmetic product development were asked to rate skin feelings when a range of petroleum jelly and cream samples are applied to the skin. Primary skin feel, or the spreadability of a cosmetic product, was correlated to the product's flow onset and maximum viscosity as measured by a Anton Paar rheometer, whereas secondary skin feel or the sensation occurring at the end of application when the product was completely rubbed into the skin was correlated to the product's viscosity measured at high shear rates. The cream samples prepared with a petroleum jelly containing 10% and 20% Fischer-Tropsch wax fell within the boundary of good primary skin feeling of cream products. Predominantly, synthetic petroleum jellies were given the best assessments in terms of primary skin feeling and were used with mineral-based petroleum jellies to determine the boundary of good primary skin feeling for petroleum jelly products. The further away a product falls from this rheological boundary the poorer the skin feeling assessment appears to be by the panel. Products containing Fischer-Tropsch waxes were given the best assessment by the panel for secondary skin feeling. Comments from the panel include that these products feel silky and light on the skin. The higher the Fischer-Tropsch wax content, the lower viscosity was at high shear rate (ϒ = 500 s(-1) ) and the higher the assessment by the panel. Rheological measurements can be used to objectively determine skin sensation when products are applied to the skin; this may shorten research and development times. A rheology boundary of certain product viscosity and shear stress applied is associated with good primary skin feeling for lotions, creams and petroleum jellies. Lower product viscosity

  9. [Feliks Karol Koneczny - academic career path].

    PubMed

    Biliński, Piotr

    2005-01-01

    Feliks Koneczny's ideas in history and philosophy of history are well-known in today's world. Since the 1990s many researchers have devoted their interests and studies to that very matter. They have written a lot about the issue. Yet there hasn't been even one thorough biography of that outstanding scholar based on an in-depth archival query. It was the author's research conducted in national and foreign archives, that finally provided the answer to the hitherto unexplained, mysteries concerning Feliks Koneczny. Feliks Koneczny (1862-1949) graduated from the Faculty of Philosophy at the Jagiellonian University in Cracow and began work as an office senior lecturer at the Academy of Arts and Sciences; since 1897, he worked at the Jagiellonian Library. After Poland regained its independence, he became an assistant professor in 1919. In June 1920, after he had qualified received the degree of doctor habilitatus, he became a professor of the Stefan Batory University in Vilnius. After having retired in 1929, he came back to Cracow. His interests moved from purely historical research to the philosophy of history, religion and philosophy. During the Second World War his two sons were killed by the Nazis, and part of his house was occupied by German co-tenants. His pioneering works dealing with the history of Russia. As well as his theory the evolution of civilizations are among his greatest achievements. Foreign researchers and scholars, among them Anton Hilckman, Arnold Toynbee and Samuel Huntington widely draw upon Feliks Koneczny's works and achievements. In 1948, after sixty years of research work Koneczny calculated that his written scholarly output encompassed 26 volumes, each of them being 300 to 400 pages long, not to mention more than 300 articles, brochures and reprints. Although a lot of Polish scholars can boast of having completed more works than he had not many Polish historians can prode themselves on such an enormous scape of research, which included

  10. Land surface model over forest and lake surfaces in a boreal site - Evaluation of the tiling method

    NASA Astrophysics Data System (ADS)

    Manrique Suñén, A.; Nordbo, A.; Balsamo, G.; Beljaars, A.; Mammarella, I.

    2012-04-01

    Land surface model over forest and lake surfaces in a boreal site - Evaluation of the tiling method Andrea Manrique Suñén1, Annika Nordbo2, Gianpaolo Balsamo1, Anton Beljaars1 and Ivan Mammarella2 1 ECMWF, Reading, UK 2 University of Helsinki, Finland The tiling method is used by many models to represent the surface heterogeneity. Each grid-box is divided into fractions of different types of surface, and an area-weighted average of the energy fluxes is computed to couple with the atmosphere. This method provides a flexible characterisation of land complexity, and separate information of sub grid variables. However, not much assessment of its validity has been carried out. To evaluate results for two contrasting surfaces, the Hydrology Tiled ECMWF Scheme for Surface Exchanges has been run offline for the year 2006, forced by the ERA-Interim reanalysis data over a boreal site in southern Finland for two cases. The first one corresponds to a full coverage of the grid-box by high vegetation, and the second one to a full coverage by a lake. The lake model Flake was incorporated into the system to represent inland water processes. It uses a simple parameterisation which has proved to perform well for numerical weather prediction. The resulting fluxes for both cases have been compared to observational data from two stations situated near each other in a Scots pine forest (Hyytiälä) and in a small boreal lake (Valkea-Kotinen), in southern Finland. The turbulent fluxes at the sites were measured using the Eddy-covariance technique. Net radiation, change in heat storage, wind speed, air temperature, and specific humidity and surface pressure were also available for each site. The diurnal and seasonal cycles of the energy fluxes for these contrasting surfaces have been evaluated, and the different energy partitioning has been explained. In general, the effect of the lake's thermal inertia is well represented by the model. The only shortcoming of the lake model appears to

  11. Possible changes in ground-water flow to the Pecos River caused by Santa Rosa Lake, Guadalupe County, New Mexico

    USGS Publications Warehouse

    Risser, D.W.

    1987-01-01

    In 1980 Santa Rosa Dam began impounding water on the Pecos River about 7 miles north of Santa Rosa, New Mexico, to provide flood control, sediment control, and storage for irrigation. Santa Rosa Lake has caused changes in the groundwater flow system, which may cause changes in the streamflow of the Pecos River that cannot be detected at the present streamflow gaging stations. Data collected at these stations are used to measure the amount of water available for downstream users. A three-dimensional groundwater flow model for a 950 sq mi area between Anton Chico and Puerto de Luna was used to simulate the effects of Santa Rosa Lake on groundwater flow to a gaining reach of the Pecos River for lake levels of 4,675, 4,715, 4,725, 4,750, 4,776, and 4,797 feet above sea level and durations of impoundment of 30, 90, 182, and 365 days for all levels except 4 ,797 feet. These simulations indicated that streamflow in the Pecos River could increase by as much as 2 cu ft/sec between the dam and Puerto de Luna if the lake level were maintained at 4 ,797 feet for 90 days or 4,776 feet for 1 year. About 90% of this increased streamflow would occur < 0.5 mi downstream from the dam, some of which would be measured at the streamflow gaging station located 0.2 mile downstream from the dam. Simulations also indicated that the lake will affect groundwater flow such that inflow to the study area may be decreased by as much as 1.9 cu ft/sec. This water may leave the Pecos River drainage basin or be diverted back to the Pecos River downstream from the gaging station near Puerto de Luna. In either case, this quantity represents a net loss of water upstream from Puerto de Luna. Most simulations indicated that the decrease in groundwater flow into the study area would be of about the same quantity as the simulated increase in streamflow downstream from the dam. Therefore, the net effect of the lake on the flow of the Pecos River in the study area appears to be negligible. Model simulations

  12. All-Manganite Tunnel Junctions with Interface-Induced Barrier Magnetism

    NASA Astrophysics Data System (ADS)

    Sefrioui, Zouhair

    2011-03-01

    The recent discovery of several unexpected phases at complex oxide interfaces is providing new insights into the physics of strongly correlated electron systems. The possibility of tailoring the electronic structure of such interfaces has triggered a great technological drive to functionalize them into devices. In this communication, we describe an alternative strategy to produce spin filtering by inducing a ferromagnetic insulating state in an ultrathin antiferromagnetic layer in contact with a ferromagnetic layer. This artificially induced spin filtering persists up to relatively high temperatures and operates at high applied bias voltages. The results suggest that after playing a key role in exchange-bias for spin-valves, uncompensated moments at engineered antiferromagnetic interfaces represent a novel route for generating highly spin-polarized currents with antiferromagnets. Work done in collaboration with M. Bibes, C. Carrétéro, A. Barthélémy (Unité Mixte de Physique CNRS/Thales, Campus de Polytechnique, 1, Avenue A. Fresnel, 91767 Palaiseau (France) and Université Paris-Sud, 91045 Orsay (France)), F.A. Cuellar, C. Visani, A. Rivera-Calzada, , C. León, J. Santamaria (Grupo de Física de Materiales Complejos, Universidad Complutense de Madrid, 28040 Madrid (Spain)), M.J. Calderón, L. Brey (Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid (Spain)), K. March, M. Walls, D. Imhoff (Laboratoire de Physique des Solides, CNRS, Université Paris-Sud, 91405 Orsay (France)), R. Lopez Anton, T.R. Charlton (ISIS, Rutherford Appleton Laboratory, Chilton, Oxon OX11 0QX (United Kingdom)), E. Iborra (Universidad Politécnica de Madrid, Escuela Técnica Superior de Ingenieros de Telecomunicaciones, 28040 Madrid (Spain)), F. Ott (Léon Brillouin, CEA/CNRS, UMR 12, 91191 Gif-sur-Yvette (France)). This work was supported by the Spanish Ministry for Science and Education programs MAT2008 06517, and the Réseau Thématique de Recherche Avanc

  13. Accurate values of some thermodynamic properties for carbon dioxide, ethane, propane, and some binary mixtures.

    PubMed

    Velasco, Inmaculada; Rivas, Clara; Martínez-López, José F; Blanco, Sofía T; Otín, Santos; Artal, Manuela

    2011-06-30

    Quasicontinuous PρT data of CO(2), ethane, propane, and the [CO(2) + ethane] mixture have been determined along subcritical, critical, and supercritical regions. These data have been used to develop the optimal experimental method and to determine the precision of the results obtained when using an Anton Paar DMA HPM vibrating-tube densimeter. A comparison with data from reference EoS and other authors confirm the quality of our experimental setup, its calibration, and testing. For pure compounds, the value of the mean relative deviation is MRD(ρ) = 0.05% for the liquid phase and for the extended critical and supercritical region. For binary mixtures the mean relative deviation is MRD(ρ) = 0.70% in the range up to 20 MPa and MRD(ρ) = 0.20% in the range up to 70 MPa. The number of experimental points measured and their just quality have enable us to determine some derivated properties with satisfactory precision; isothermal compressibilities, κ(T), have been calculated for CO(2) and ethane (MRD(κ(T)) = 1.5%), isobaric expasion coefficients, α(P), and internal pressures, π(i), for CO(2) (MRD(α(P)) = 5% and MRD(π(i)) = 7%) and ethane (MRD(α(P)) = 7.5% and MRD(π(i)) = 8%). An in-depth discussion is presented on the behavior of the properties obtained along subcritical, critical, and supercritical regions. In addition, PuT values have been determined for water and compressed ethane from 273.19 to 463.26 K up to pressures of 190.0 MPa, using a device based on a 5 MHz pulsed ultrasonic system (MRD(u) = 0.1%). With these data we have calibrated the apparatus and have verified the adequacy of the operation with normal liquids as well as with some compressed gases. From density and speed of sound data of ethane, isentropic compressibilities, κ(s), have been obtained, and from these and our values for κ(T) and α(P), isobaric heat capacities, C(p), have been calculated with MRD(C(p)) = 3%, wich is within that of the EoS. PMID:21639086

  14. Polymerase chain reaction: basic protocol plus troubleshooting and optimization strategies.

    PubMed

    Lorenz, Todd C

    2012-05-22

    In the biological sciences there have been technological advances that catapult the discipline into golden ages of discovery. For example, the field of microbiology was transformed with the advent of Anton van Leeuwenhoek's microscope, which allowed scientists to visualize prokaryotes for the first time. The development of the polymerase chain reaction (PCR) is one of those innovations that changed the course of molecular science with its impact spanning countless subdisciplines in biology. The theoretical process was outlined by Keppe and coworkers in 1971; however, it was another 14 years until the complete PCR procedure was described and experimentally applied by Kary Mullis while at Cetus Corporation in 1985. Automation and refinement of this technique progressed with the introduction of a thermal stable DNA polymerase from the bacterium Thermus aquaticus, consequently the name Taq DNA polymerase. PCR is a powerful amplification technique that can generate an ample supply of a specific segment of DNA (i.e., an amplicon) from only a small amount of starting material (i.e., DNA template or target sequence). While straightforward and generally trouble-free, there are pitfalls that complicate the reaction producing spurious results. When PCR fails it can lead to many non-specific DNA products of varying sizes that appear as a ladder or smear of bands on agarose gels. Sometimes no products form at all. Another potential problem occurs when mutations are unintentionally introduced in the amplicons, resulting in a heterogeneous population of PCR products. PCR failures can become frustrating unless patience and careful troubleshooting are employed to sort out and solve the problem(s). This protocol outlines the basic principles of PCR, provides a methodology that will result in amplification of most target sequences, and presents strategies for optimizing a reaction. By following this PCR guide, students should be able to: • Set up reactions and thermal cycling

  15. Post-translational Modification of Ribosomal Proteins - Structural and Functional Characterization of RimO from Thermotoga Maritima, A Radiacal S-Adenosylmethionine Methylthiotransferase

    SciTech Connect

    Arragain, S.; Garcia-Serres, R; Blondin, G; Douki, T; Clemancey, M; Latour, J; Forouhar, F; Neely, H; Montelione, G; et. al.

    2010-01-01

    Post-translational modifications of ribosomal proteins are important for the accuracy of the decoding machinery. A recent in vivo study has shown that the rimO gene is involved in generation of the 3-methylthio derivative of residue Asp-89 in ribosomal protein S12 (Anton, B. P., Saleh, L., Benner, J. S., Raleigh, E. A., Kasif, S., and Roberts, R. J. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 1826-1831). This reaction is formally identical to that catalyzed by MiaB on the C2 of adenosine 37 near the anticodon of several tRNAs. We present spectroscopic evidence that Thermotoga maritima RimO, like MiaB, contains two [4Fe-4S] centers, one presumably bound to three invariant cysteines in the central radical S-adenosylmethionine (AdoMet) domain and the other to three invariant cysteines in the N-terminal UPF0004 domain. We demonstrate that holo-RimO can specifically methylthiolate the aspartate residue of a 20-mer peptide derived from S12, yielding a mixture of mono- and bismethylthio derivatives. Finally, we present the 2.0 {angstrom} crystal structure of the central radical AdoMet and the C-terminal TRAM (tRNA methyltransferase 2 and MiaB) domains in apo-RimO. Although the core of the open triose-phosphate isomerase (TIM) barrel of the radical AdoMet domain was conserved, RimO showed differences in domain organization compared with other radical AdoMet enzymes. The unusually acidic TRAM domain, likely to bind the basic S12 protein, is located at the distal edge of the radical AdoMet domain. The basic S12 protein substrate is likely to bind RimO through interactions with both the TRAM domain and the concave surface of the incomplete TIM barrel. These biophysical results provide a foundation for understanding the mechanism of methylthioation by radical AdoMet enzymes in the MiaB/RimO family.

  16. Post-translational Modification of Ribosomal Proteins: Structural and Functional Characterization of RimO from Thermotoga maritima, a Radical S-adenosylmethionine methylthiotransferase

    SciTech Connect

    Arragain, S.; Latour, J; Forouhar, F; Neely, H; Montelione, G; Hunt, J; Mulliez, E; Fontecave, M; Atta, M; et al.

    2010-01-01

    Post-translational modifications of ribosomal proteins are important for the accuracy of the decoding machinery. A recent in vivo study has shown that the rimO gene is involved in generation of the 3-methylthio derivative of residue Asp-89 in ribosomal protein S12 (Anton, B. P., Saleh, L., Benner, J. S., Raleigh, E. A., Kasif, S., and Roberts, R. J. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 1826-1831). This reaction is formally identical to that catalyzed by MiaB on the C2 of adenosine 37 near the anticodon of several tRNAs. We present spectroscopic evidence that Thermotoga maritima RimO, like MiaB, contains two [4Fe-4S] centers, one presumably bound to three invariant cysteines in the central radical S-adenosylmethionine (AdoMet) domain and the other to three invariant cysteines in the N-terminal UPF0004 domain. We demonstrate that holo-RimO can specifically methylthiolate the aspartate residue of a 20-mer peptide derived from S12, yielding a mixture of mono- and bismethylthio derivatives. Finally, we present the 2.0 {angstrom} crystal structure of the central radical AdoMet and the C-terminal TRAM (tRNA methyltransferase 2 and MiaB) domains in apo-RimO. Although the core of the open triose-phosphate isomerase (TIM) barrel of the radical AdoMet domain was conserved, RimO showed differences in domain organization compared with other radical AdoMet enzymes. The unusually acidic TRAM domain, likely to bind the basic S12 protein, is located at the distal edge of the radical AdoMet domain. The basic S12 protein substrate is likely to bind RimO through interactions with both the TRAM domain and the concave surface of the incomplete TIM barrel. These biophysical results provide a foundation for understanding the mechanism of methylthioation by radical AdoMet enzymes in the MiaB/RimO family.

  17. Müller cell gliotic response in the retina of the newts exposed to real and simulated microgravity

    NASA Astrophysics Data System (ADS)

    Grigoryan, Eleonora N.; Poplinskaya, Valentina; Domaratskaya; Aleinikova, Karina; Novikova, Julia; Anton, Hermann J.; Almeida, Eduardo

    The effects of real and simulated microgravity on the eye tissue regeneration of newts (Pl. waltli) after lens and/or retina removal were investigated. Changes in Müller glial cells in the retina of eyes regenerating after lens extirpation were detected in newts exposed to clinostat-ing. The cells were hypertrophied, and their processes thickened. Such changes were viewed as specific of reactive gliosis [1]. Later experiments onboard the Russian biosatellite Bion-11 showed similar changes in the retinas of newts regenerating after a two-week spaceflight. In the Bion-11 animals, GFAP, the major structural protein of macroglial cells was found to be up-regulated [2]. In more recent experiments onboard Foton-2 (2005) and Foton-M3 (2007), GFAP expression in retinas of space-flown, ground control (kept at 1 g), and basal control (sacrificed on launch day) newts was quantified, using microscopy, immunohistochemistry, and digital image analysis. It was found that Müller cell processes of non-operated animals dis-u played low GFAP immunolabeling. A low level of immunoreactivity was also observed in basal controls. In contrast, retinas of space-flown animals showed greater GFAP immunoreactivity associated with both an increased cell number and a higher density of intermediate filaments [3]. This, in turn, was accompanied by up-regulation of stress protein (HSP90) and growth factor (FGF2) expressions. It can be postulated that such a response of Müller cells was to mitigate the retinal stress in newts exposed to microgravity. Although the exact mechanisms remain unknown, it can be hypothesized that GFAP up-regulation is mediated by HSPs and growth factors, particularly by FGF2. Taken together, these data suggest that the retinal population of macroglial cells is sensitive to gravity changes and that in space it can react by enhancing its neuroprotective function. [1] Grigoryan E.N., Anton H.J., Mitashov V.I. Adv. Space Res. 1998. V. 22. N.2. P. 293-301. [2] Grigoryan E

  18. Viscosity of carbonate-rich melts under different oxygen fugacity conditions

    NASA Astrophysics Data System (ADS)

    Di Genova, Danilo; Hess, Kai-Uwe; Cimarelli, Corrado; Dingwell, Donald B.

    2015-04-01

    Viscosity is a fundamental property of many materials and its changes affects the fluid dynamics of natural system as well as industrial processes. The mobility of carbonatitic melts, which are carbonate-rich and very fluid melts, has attracted renewed interest in both earth science and industry. In fact, these melts are considered the main transport agent of carbon from the mantle to the crust and may be intimately linked to the generation of kimberlites. At the same time lithium, potassium and sodium carbonate are used as electrolytes in molten carbonate fuel cells which operate at high temperatures (~650° C) for the production of electricity without CO2 emissions. Accurate measurement of the transport property (i.e. viscosity) of carbonatitic melts is a priority in order to understand the carbonatite mobility and reaction rates. Additionally, obtaining accurate viscosity measurements of such low viscosity melts is however an experimental challenge due to volatility, very low torques and chemical melt instability in the viscometer. To overcome these limitations we have customized a Modular Compact Rheometer (MCR 502 from Anton Paar) ad hoc equipped with 2 narrow gap concentric-cylinder geometries of steel and Pt-Au. The rheometer is characterized by an air-bearing-supported synchronous motor with torque ranging between 0.01 μNm and 230 mNm (resolution of 0.1 nNm), achieving very low viscosity measurements in the order of mPa s, temperatures up to 1000° C and shear rates ranging between 1 and 100 sec-1. These experimental conditions well match the temperature-viscosity-shear rate window relevant for carbonate melts. Here we present the calibration of the rheometer and the results of a rheological characterization study on a series of very low viscous synthetic and natural carbonatitic melts at different oxygen fugacity (air and CO2 saturated atmosphere). Viscosity measurements on carbonate melts have been performed in the temperature range between ~650 and 1000

  19. Perspective View with Color-Coded Shaded Relief, Central Panama

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This perspective view shows central Panama, with the remnants of the extinct volcano El Valle in the foreground and the Caribbean Sea in the distance. El Valle underwent an explosive eruption about 3 million years ago, forming a crater 5 kilometers (3.1 miles) across, one of the largest in the Americas. The crater subsequently filled with water forming a huge lake, but about 12,000 years ago a breach at the present site of the waterfall Choro de las Mozas caused it to drain, forming the present valley. Within the crater is the town of El Valle de Anton, whose 600-meter (1,968-foot) elevation and resulting cooler climate make it a popular tourist and vacation site.

    The lake in the distance is Lake Gatun, at the west end of the Panama Canal. The canal itself extends to the southwest (to the right in this northeast facing view) but is hidden by the intervening terrain.

    This shaded relief perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM). A computer-generated artificial light source illuminates the elevation data to produce a pattern of light and shadows. Slopes facing the light appear bright, while those facing away are shaded. On flatter surfaces, the pattern of light and shadows can reveal subtle features in the terrain. Colors show the elevation as measured by SRTM, and range from green at the lowest elevations to white at the highest elevations.

    SRTM, launched on February 11, 2000, uses the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. The mission is designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, an additional C-band imaging antenna and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) and the

  20. Kinematics of an oblique deformation front using paleomagnetic data; the Altomira-Loranca structures (Iberian Chain, Central Spain)

    NASA Astrophysics Data System (ADS)

    Valcarcel, M.

    2013-05-01

    Manoel Valcárcel1, 5, Ruth Soto2, Elisabet Beamud3, Belén Oliva-Urcia4 and Josep Anton Muñoz5 1 IGME, Departamento de Investigación y Prospección Geocientífica. C/ La Calera, 1, 28760 Tres Cantos; m.valcarcel@igme.es 2 IGME, Unidad de Zaragoza, C/ Manuel Lasala 44, 9 B, 50006 Zaragoza, Spain 3 Lab. Paleomagnetisme (CCiT UB-CSIC). ICT "Jaume Almera", Solé i Sabarís, s/n, 08028 Barcelona, Spain. 4 IPE-CSIC, Avda. Montañana 1005, 50059 Zaragoza, Spain 5 Grup Geodinàmica i Anàlisi de Conques, Universitat de Barcelona, Zona Universitària Pedralbes, 08028 Barcelona, Spain The Altomira and Loranca structures consist of a fold-and-thrust system detached on Triassic evaporites. They are oriented N-S to NNE-SSW and NNW-SSE at its northern and southern end, respectively, forming a subtle arc, oblique with respect to the general NW-SE trend of the Iberian Chain. The aim of this work is to characterize with paleomagnetic data the kinematic evolution of the the Altomira Range, located at the southwestern deformation front of the Iberian Chain, and of the structures within its associated piggy-back basin, the Loranca basin. This approach will also give clues regarding the primary and/or secondary origin of these structures to better characterize them in further studies (3D reconstruction and restoration, fault pattern). A total of 180 samples were obtained from 19 sites in Eocene, Oligocene and Miocene rocks (including clays, fine sandstones and limestones). They were analyzed by means of stepwise thermal demagnetization and subsequent measurement of the natural remanent magnetization (NRM). Although fold tests are not statistically significant, a primary origin of the magnetization is deduced by samples showing either normal or reverse polarity after bedding correction of the calculated characteristic components. Declinations of the site mean directions appear scattered after bedding correction suggesting differential vertical-axis rotations. Sites located at the

  1. An annotated catalogue and bibliography of the taxonomy, synonymy and distribution of the Recent Vetigastropoda of South Africa (Mollusca).

    PubMed

    Herbert, David G

    2015-11-30

    A complete inventory of the known Recent vetigastropod fauna of South Africa is provided. Bibliographic citations to works discussing the taxonomy, synonymy and distribution of the species in a southern African or south-western Indian Ocean context are provided. Additional explanatory notes are given where pertinent. New genus records for South Africa: Acremodontina B.A. Marshall, 1995; Choristella Bush, 1879; Cocculinella Thiele, 1909; Conjectura Finlay, 1926; Crosseola Iredale, 1924; Falsimargarita Powell, 1951; Lepetella Verrill, 1880; Profundisepta McLean & Geiger, 1998; Stomatella Lamarck, 1816; Stomatia Helbling, 1779; Stomatolina Iredale, 1937; Synaptocochlea Pilsbry, 1890; Tibatrochus Nomura, 1940; Visayaseguenzia Poppe, Tagaro & Dekker, 2006; Zetela Finlay, 1926. New species records for South Africa: Acremodontina aff. carinata Powell, 1940; Anatoma finlayi (Powell, 1937); Anatoma munieri (P. Fischer, 1862); Calliotropis acherontis B.A. Marshall, 1979; Calliotropis bucina Vilvens, 2006; Cocculinella minutissima (E.A. Smith, 1904); Diodora ruppellii (G.B. Sowerby (I), 1835); Emarginula costulata Deshayes, 1863; Emarginula decorata Deshayes, 1863; Jujubinus hubrechti Poppe, Tagaro & Dekker, 2006; Lepetella sp.; Seguenzia orientalis Thiele, 1925; Stomatella auricula Lamarck, 1816; Stomatia phymotis Helbling, 1779; Stomatolina angulata (A. Adams, 1850); Stomatolina cf. calliostoma (A. Adams, 1850); Stomatolina aff. danblumi Singer & Mienis, 1999; Stomatolina cf. rubra (Lamarck, 1822); Stomatolina sp.; Synaptocochlea concinna (Gould, 1845); Tectus mauritianus (Gmelin, 1791); Tibatrochus cf. incertus (Schepman, 1908); Turbo imperialis Gmelin, 1791; Turbo tursicus Reeve, 1848; Visayaseguenzia compsa (Melvill, 1904).New species: Spectamen martensi, replacement name for Spectamen semisculptum sensu Herbert (1987) (non Martens, 1904). New name: Oxystele antoni is proposed as a new name for Trochus (Turbo) variegatus (non Gmelin, 1791 =Heliacus) Anton, 1838. Revised

  2. [Correlations of stress, coping and psychological well-being among preclinical medical students].

    PubMed

    Pikó, Bettina

    2014-08-17

    Bevezetés: A stressz-szint már orvostanhallgatók körében is igen magas, ezért fontos lenne felkészítésük a megelőzésre. Célkitűzés: A szerzők célul tűzték ki orvostanhallgatók stressz-szintjének, pszichoszomatikus tüneteinek, copingstratégiáinak, valamint az élettel való elégedettségük mértékének vizsgálatát. Módszer: Preklinikai orvostanhallgatókat (N = 155) kérdeztek a Szegedi Tudományegyetemen. Az adatgyűjtésre csoportos formában, önkitöltés útján került sor, önkéntes és anonim módon. Eredmények: A felmérésben részt vevő orvostanhallgatók stresszterheltségi szintje és élettel való elégedettségének mértéke megfelelt a nemzetközi, illetve a hazai adatoknak. Nemek szerint nem volt eltérés az élettel való elégedettség mértékében, a stresszterheltség és a pszichoszomatikus index viszont lányok esetében magasabb volt. Az élettel való elégedettséget elsősorban az észlelt stressz-szint, valamint a copingmódok befolyásolták. Következtetések: Preklinikai orvostanhallgatók stresszterheltsége, pszichoszomatikus tünetképzése, az általuk alkalmazott copingstílusok, valamint az élettel való elégedettség között jelentős összefüggések vannak. Az orvosképzés során szükség van olyan készségek fejlesztésére is, mint a hatékony konfliktusmegoldási vagy stresszkezelési technikák. Orv. Hetil, 2014, 155(33), 1312–1318.

  3. Characteristics of sewage sludge and distribution of heavy metal in plants with amendment of sewage sludge.

    PubMed

    Dai, Jia-yin; Chen, Ling; Zhao, Jian-fu; Ma, Na

    2006-01-01

    In order to better understand land application of sewage sludge, the characterization of heavy metals and organic pollutants were investigated in three different sewage sludges in Shanghai City, China. It was found that the total concentrations of Cd in all of sewage sludge and total concentrations of Zn in Jinshan sewage sludge, as well as those of Zn, Cu, and Ni in Taopu sludge are higher than Chinese regulation limit of pollutants for sludge to be used in agriculture. Leachability of Hg in all of studied samples and that of Cd in Taopu sewage sludge exceed the limit values of waste solid extraction standard in China legislation. Based on the characteristics for three kinds of sewage sludge, a pot experiment was conducted to investigate the effect of soil amended with Quyang sewage sludge on the accumulation of heavy metal by Begonia semperflorens-hybr; Ophiopogon japonicus (L.F.) Ker-Gaw; Loropetalum chindense-var. rubrum; Dendranthema morifolium; Viola tricolor; A ntirrhinum majus; Buxus radicans Sieb; Viburnum macrocephalum; Osmanthus fragrans Lour; Cinnamomum camphora siebold and Ligustrum lucidum ait. Results showed that 8 species of plant survived in the amended soil, and moreover they flourished as well as those cultivated in the control soil. The heavy metal concentration in plants varied with species, As, Pb, Cd and Cr concentration being the highest in the four herbaceous species studied, particularly in the roots of D. morifolium. These plants, however, did not show accumulator of As, Pb, Cd and Cr. The highest concentration of Ni and Hg was found in the roots of D. morifolium, followed by the leaves of B. semperflorens-hybr. Levels of Zn and Cu were much higher in D. morifolium than in the other plant species. D. morifolium accumulated Ni, Hg, Cu and Zn, which may contribute to the decrease of heavy metal contents in the amended soil. Treatment with sewage sludge did not significantly affect the uptake of heavy metals by the L. chindense-var. rubrum

  4. The OD/OH Isotope Ratio in Comets 8P/Tuttle and C/2012 F6 (Lemmon)

    NASA Astrophysics Data System (ADS)

    Rousselot, Philippe; Jehin, Emmanuel; Hutsemekers, Damien; Manfroid, Jean; Decock, Alice; Bockelee-Morvan, Dominique

    2016-10-01

    The determination of isotopic ratios in solar system objects is an important source of information about their origin, especially for comets. Among these ratios the D/H is of particular importance because of its sensitivity to fractionation processes and physical environment, and the abundance of hydrogen in the solar system. The main molecule used to derive this ratio in comets is water. So far, apart water, only HCN has permitted to derive D/H ratio and not only upper limits.Most of the existing determinations of D/H in water molecules have been obtained by spectroscopic observations of water lines in the sub-mm or near infrared range [1,2]. So far only one measurement has been based on OD/OH emission lines radicals in the near-UV [3] and another one on the Lyman-alpha D emission [4]. In situ measurements have also been obtained in comets 1P/Halley and 67P/Churyumov-Gerasimenko using mass spectrometer [5,6,7,8].In this work we have used the OH and OD ultraviolet bands at 310 nm observed with the ESO 8-m Very Large Telescope feeding the Ultraviolet-Visual Echelle Spectrograph (UVES) for measuring the D/H ratio in comets 8P/Tuttle and C/2012 F6 (Lemmon). The OH and OD being the photodissociation products of H2O and HDO such observations allow to derive D/H ratio for water molecules. This work constitutes an independant determination of the D/H ratios already published for these comets and based on observations performed in the sub-mm and near infrared range of H2O and HDO lines. We present our modeling, data analysis and numerical values obtained for this ratio.[1] D. Bockelée-Morvan et al., 2015, SSR 197, 47-83 [2] N. Biver et al., 2016, A&A 589, id A78, 11p [3] D. Hutsemékers et al., 2008, A&A 490, L31 [4] H.A. Weaver et al., 2008, LPI Contributions 1405, 8216 [5] H. Balsiger, K. Altwegg, J. Geiss, 1995, JGR 100, 5827 [6] P. Eberhardt et al., 1995, A&A 302, 301 [7] R.H. Brown et al., 2012, PSS 60, 166 [8] K. Alwegg et al., 2015, Science 347, article id. 1261952

  5. The NA62 trigger system

    NASA Astrophysics Data System (ADS)

    Krivda, M.; NA62 Collaboration

    2013-08-01

    The main aim of the NA62 experiment (NA62 Technical Design Report, [1]) is to study ultra-rare Kaon decays. In order to select rare events over the overwhelming background, central systems with high-performance, high bandwidth, flexibility and configurability are necessary, that minimize dead time while maximizing data collection reliability. The NA62 experiment consists of 12 sub-detector systems and several trigger and control systems, for a total channel count of less than 100,000. The GigaTracKer (GTK) has the largest number of channels (54,000), and the Liquid Krypton (LKr) calorimeter shares with it the largest raw data rate (19 GB/s). The NA62 trigger system works with 3 trigger levels. The first trigger level is based on a hardware central trigger unit, so-called L0 Trigger Processor (L0TP), and Local Trigger Units (LTU), which are all located in the experimental cavern. Other two trigger levels are based on software, and done with a computer farm located on surface. The L0TP receives information from triggering sub-detectors asynchronously via Ethernet; it processes the information, and then transmits a final trigger decision synchronously to each sub-detector through the Trigger and Timing Control (TTC) system. The interface between L0TP and the TTC system, which is used for trigger and clock distribution, is provided by the Local Trigger Unit board (LTU). The LTU can work in two modes: global and stand-alone. In the global mode, the LTU provides an interface between L0TP and TTC system. In the stand-alone mode, the LTU can fully emulate L0TP and so provides an independent way for each sub-detector for testing or calibration purposes. In addition to the emulation functionality, a further functionality is implemented that allows to synchronize the clock of the LTU with the L0TP and the TTC system. For testing and debugging purposes, a Snap Shot Memory (SSM) interface is implemented, that can work

  6. Mapping a Mantle Xenolith Using Micro X-ray Diffraction

    NASA Astrophysics Data System (ADS)

    Harwood, B. P.; Flemming, R. L.; Stachel, T.

    2009-05-01

    With the advent of Micro X-ray diffraction (μXRD), mineral mapping is now possible at the thin section scale, using crystal structural rather than chemical properties. To test the effectiveness of this technique, a Brüker D8 Discover μXRD was used to create mineral maps from two garnet lherzolite xenoliths from the Bultfontein kimberlite recovered on the Boshof road dumps (Kimberley, South Africa). This technique generated a 2D representation of the major mineralogy (olivine + garnet + clinopyroxene + orthopyroxene + phlogopite); it also enabled estimation of the modal proportions of each mineral. For one polished section, two sets of μXRD data were collected along grids having spacing of 0.5 mm (1148 points) and 1.5 mm (516 points), respectively. The 0.5 mm spacing coincided with the X-ray beam diameter, leaving no gaps in coverage. Data were also collected using a grid of 1.5 mm spacing to examine the effectiveness of a low- resolution map, which would be advantageous to decrease the time required for data collection and processing. To test the potential for automation of the method, data were collected for a second polished thin section, using the high resolution grid (0.5 mm spacing, 3312 data points). General Area Diffraction Detection System (GADDS) images were collected and processed at each step. Debye rings were integrated along small "slices" of 2θ to yield the total number of counts in that area. The 2θ ranges used to identify each phase were chosen such that they coincided with regions where there was no overlap with peaks from any of the other four major phases. To compensate for variable orientation of the grains in the thin sections, several d-spacings (2θ ranges) were integrated for each mineral, and then added together to create five "overall" mineral maps. To create final maps, minerals were determined to be 'present' in cells where the number of counts was above a threshold level in the "overall" map for that mineral. The maps provided

  7. A new technique for trace elemental analysis of speleothems using microbeam xrf

    NASA Astrophysics Data System (ADS)

    Buckles, J.; Rowe, H.; Gao, Y.; Cheng, H.; Edwards, R. L.; Springer, G.; Hardt, B.

    2012-04-01

    Trace element ratios in speleothems (Sr/Ca, Mg/Ca, Ba/Ca) have been used to interpret the hydrogeochemical processes in the epikarst zone as well as the partitioning that occurs at the calcite-water interface. During periods of low rainfall, trace element ratios generally increase as a result of the longer residence time of water in the soil and epikarst zones. High-resolution time series analyses of these elements in speleothems provide evidence for changing paleohydrological and geochemical conditions over time. The conventional methods of trace metal analysis of speleothems- Laser Ablation Inductively-Coupled Plasma Mass Spectrometry (LA-ICPMS) and Inductively-Coupled Plasma Optical Emission Spectroscopy (ICP-OES) have yielded many high-quality data sets. However, these methods can be expensive, time-consuming, and require the destruction - either by ablation, micro-milling, or powdering of speleothem samples. The many caveats of these conventional methods have led to the search for a viable alternative - one that will provide the same high-resolution result, but that is affordable, rapid, and non-destructive. Presented here are trace element analysis results using microbeam X-ray Fluorescence Spectrometry. The Brüker-AXS ARTAX microbeam XRF spectrometer permits a multi-element analysis from Na to U with a spatial resolution of 70 µm. The method is non-contact and non-destructive, therefore preserving the sample for additional analyses (e.g. stable isotopes). A simple calibration method for Sr/Ca using pressed mixed powders will be described. It will be demonstrated that microbeam XRF is an important tool in trace element analysis of speleothems and a viable alternative to conventional methods. Sr/Ca ratios were obtained for multiple speleothems and serve as a preliminary test of microbeam XRF suitability. Analyses of variable count times, temporal and spatial reproducibility along transects, and a comparison between microbeam XRF spectra and ICP-OES spectra

  8. Extreme weather impacts on European networks of transport

    NASA Astrophysics Data System (ADS)

    Leviakangas, P.

    2012-04-01

    : Pekka Leviäkangas, Anu Tuominen, Riitta Molarius, Heta Kojo, Jari Schabel, Sirra Toivonen, Jaana Keränen, Johanna Ludvigsen, Andrea Vajda, Heikki Tuomenvirta, Ilkka Juga, Pertti Nurmi, Jenni Rauhala, Frank Rehm, Thomas Gerz, Thorsten Muehlhausen, Juha Schweighofer, Silas Michaelides, Matheos Papadakis, Nikolai Dotzek (†), Pieter Groenemeijer.

  9. Fragmentation of Small Molecules by Photo-Double Ionization

    NASA Astrophysics Data System (ADS)

    Osipov, Timur

    2008-05-01

    Molecular structure, formation, breakup pathways and recombination formed the subject of many theoretical and experimental studies. Among molecular species like H2, CO, N2, O2 recently great attention has been paid to the dynamics of the fragmentations and rearrangements of C2H2 molecule. Nature's smallest stable hydrocarbon, the symmetric linear acetylene molecule, C2H2, is an important polyatomic system for the study of photo initiated processes. Important features of the intramolecular dynamics in neutral acetylene have been revealed over many years through numerous spectroscopic studies. More recently, the availability of synchrotron radiation and intense laser sources has lead to intriguing studies of the ionization, isomerization and breakup dynamics of acetylene ions. Of particular interest are the yields into the symmetric (CH^+/CH^+), deprotonation (HCC^+/H^+) and quasi-symmetric (HHC^+/C^+) channels, the latter involving isomerization from the neutral acetylene structure into the vinylidene configuration prior to breakup. One expects that the products of dissociation, their kinetic energy releases (KER) and the isomerization times will depend on the particular initial electronic states of the dication involved, but such detailed information has heretofore not been available. We will present the results of the experiment where the dication of acetylene is prepared by Auger decay following core-level X-ray photoionization. Cold Target Recoil Ion Momentum Spectroscopy technique was used to measure the corresponding 3d momentum vectors of Auger electrons and recoil ions in coincidence. We will show that this experimental approach, in combination with ab initio quantum mechanical calculations, can yield a comprehensive map of the two-body dissociation pathways including transition through different electronic energy surfaces, barriers to direct dissociation and the associated rearrangement channels. Work done in collaboration with T. Rescigno, T. Weber, S

  10. Characteristics of sewage sludge and distribution of heavy metal in plants with amendment of sewage sludge.

    PubMed

    Dai, Jia-yin; Chen, Ling; Zhao, Jian-fu; Ma, Na

    2006-01-01

    In order to better understand land application of sewage sludge, the characterization of heavy metals and organic pollutants were investigated in three different sewage sludges in Shanghai City, China. It was found that the total concentrations of Cd in all of sewage sludge and total concentrations of Zn in Jinshan sewage sludge, as well as those of Zn, Cu, and Ni in Taopu sludge are higher than Chinese regulation limit of pollutants for sludge to be used in agriculture. Leachability of Hg in all of studied samples and that of Cd in Taopu sewage sludge exceed the limit values of waste solid extraction standard in China legislation. Based on the characteristics for three kinds of sewage sludge, a pot experiment was conducted to investigate the effect of soil amended with Quyang sewage sludge on the accumulation of heavy metal by Begonia semperflorens-hybr; Ophiopogon japonicus (L.F.) Ker-Gaw; Loropetalum chindense-var. rubrum; Dendranthema morifolium; Viola tricolor; A ntirrhinum majus; Buxus radicans Sieb; Viburnum macrocephalum; Osmanthus fragrans Lour; Cinnamomum camphora siebold and Ligustrum lucidum ait. Results showed that 8 species of plant survived in the amended soil, and moreover they flourished as well as those cultivated in the control soil. The heavy metal concentration in plants varied with species, As, Pb, Cd and Cr concentration being the highest in the four herbaceous species studied, particularly in the roots of D. morifolium. These plants, however, did not show accumulator of As, Pb, Cd and Cr. The highest concentration of Ni and Hg was found in the roots of D. morifolium, followed by the leaves of B. semperflorens-hybr. Levels of Zn and Cu were much higher in D. morifolium than in the other plant species. D. morifolium accumulated Ni, Hg, Cu and Zn, which may contribute to the decrease of heavy metal contents in the amended soil. Treatment with sewage sludge did not significantly affect the uptake of heavy metals by the L. chindense-var. rubrum

  11. Using intra annual density fluctuations and d13C to assess the impact of summer drought on Mediterranean ecosystem

    NASA Astrophysics Data System (ADS)

    Battipaglia, G.; Brand, W. A.; Linke, P.; Schaefer, I.; Noetzli, M.; Cherubini, P.

    2009-04-01

    Tree- ring growth and wood density have been used extensively as indicators of climate change, and tree-ring has been commonly applied as a proxy estimate for seasonal integration of temperatures and precipitation with annual resolution (Hughes 2002). While these relationships have been well established in temperate ecosystems (Fritts, 1976; Schweingruber, 1988, Briffa et al., 1998, 2004), in Mediterranean region dendrochronological studies are still scarce (Cherubini et al, 2003). In Mediterranean environment, trees may form intra-annual density fluctuations, also called "false rings" or "double rings" (Tingley 1937; Schulman 1938). They are usually induced by sudden drought events, occurring during the vegetative period, and, allowing intra-annual resolution, they may provide detailed information at a seasonal level, as well as species-specific sensitivity to drought. We investigated the variability of tree- ring width and carbon stable isotopes of a Mediterranean species, Arbutus unedo L., sampled on Elba island, (Tuscany, Italy). The samples were taken at two different sites, one characterized by wet and one by dry conditions. d13C was measured using Laser- Ablation- Combustion -GC-IRMS. Here, we present first results showing the impact of drought on tree growth and on false ring formation at the different sites and we underline the importance of using Laser Ablation to infer drought impact at the intra -annual level. Briffa KR, Schweingruber FH, Jones PD, Osborn TJ, Harris IC, Shiyatov SG, Vaganov EA, Grudd H (1998) Trees tell of past climates: but are they speaking less clearly today? Phil Transact Royal Soc London 353:65-73 Briffa KR, Osborn TJ, Schweingruber FH (2004) Large-scale temperature inferences from tree rings: a review. Glob Panet Change 40:11-26 Cherubini, P., B.L. Gartner, R. Tognetti, O.U. Bräker, W. Schoch & J.L. Innes. 2003. Identification, measurement and interpretation of tree rings in woody species from Mediterranean climates. Biol. Rev

  12. [Urgent laparoscopic adrenalectomy in acute crisis caused by pheochromocytoma].

    PubMed

    Bereczky, Bíborka; Madách, Krisztina; Gál, János; István, Gábor; Sugár, István; Ondrejka, Pál; Vörös, Attila

    2014-06-01

    Esetismertetés: A szerzők egy 30 éves nőbeteg esetét mutatják be, akinek intenzív osztályos felvételére hypertoniás krízist kísérő mellkasi panaszok, cardialis decompensatio, progrediáló acut légzési elégtelenség és tudatzavar miatt került sor. A gyors kivizsgálás mellett azonnal megkezdett intenzív terápia ellenére a felvételt követő harmadik napra többszervi elégtelenség képe alakult ki. Miután a kórkép kialakulása a bal oldali mellékvese térfoglaló folyamatára volt visszavezethető, a multidiszciplináris konzílium acut laparoscopos adrenalectomia végzése mellett foglalt állást. Az eltávolított képlet szövettani diagnózisa phaeochromocytoma volt. A postoperativ időszakban a beteg állapota fokozatosan javult, tünetei, panaszai regrediáltak, majd gyógyultan távozott. Megbeszélés: A phaeochromocytoma diagnózisa nehéz feladat, az általa kiváltott tünetek és panaszok sok egyéb kórképre is utalhatnak. Az acut phaeochromocytomás krízis általában belgyógyászati, intenzív terápiás eszközökkel uralható. A súlyos, többszervi elégtelenséghez vezető esetekben indokolt az acut műtéti beavatkozás. Az ilyen beavatkozások rizikója igen magas, de korrekt intra- és postoperativ észleléssel, megfelelő intenzív terápiával a laparoscopos műtét ezekben az esetekben választható megoldás lehet.

  13. Committees

    NASA Astrophysics Data System (ADS)

    2012-11-01

    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  14. Platelet Rich Plasma and Hyaluronic Acid Blend for the Treatment of Osteoarthritis: Rheological and Biological Evaluation

    PubMed Central

    Russo, Fabrizio; D’Este, Matteo; Vadalà, Gianluca; Cattani, Caterina; Papalia, Rocco; Alini, Mauro; Denaro, Vincenzo

    2016-01-01

    Introduction Osteoarthritis (OA) is the most common musculoskeletal disease. Current treatments for OA are mainly symptomatic and inadequate since none results in restoration of fully functional cartilage. Hyaluronic Acid (HA) intra-articular injections are widely accepted for the treatment of pain associated to OA. The goal of HA viscosupplementation is to reduce pain and improve viscoelasticity of synovial fluid. Platelet-rich plasma (PRP) has been also employed to treat OA to possibly induce cartilage regeneration. The combination of HA and PRP could supply many advantages for tissue repair. Indeed, it conjugates HA viscosupplementation with PRP regenerative properties. The aim of this study was to evaluate the rheological and biological properties of different HA compositions in combination with PRP in order to identify (i) the viscoelastic features of the HA-PRP blends, (ii) their biological effect on osteoarthritic chondrocytes and (iii) HA formulations suitable for use in combination with PRP. Materials and Methods HA/PRP blends have been obtained mixing human PRP and three different HA at different concentrations: 1) Sinovial, 0.8% (SN); 2) Sinovial Forte 1.6% (SF); 3) Sinovial HL 3.2% (HL); 4) Hyalubrix 1.5% (HX). Combinations of phosphate buffered saline (PBS) and the four HA types were used as control. Rheological measurements were performed on an Anton PaarMCR-302 rheometer. Amplitude sweep, frequency sweep and rotational measurements were performed and viscoelastic properties were evaluated. The rheological data were validated performing the tests in presence of Bovine Serum Albumin (BSA) up to ultra-physiological concentration (7%). Primary osteoarthritic chondrocytes were cultured in vitro with the HA and PRP blends in the culture medium for one week. Cell viability, proliferation and glycosaminoglycan (GAG) content were assessed. Results PRP addition to HA leads to a decrease of viscoelastic shear moduli and increase of the crossover point, due to a

  15. Optical and Acoustical Techniques for Non-viral Gene Delivery to Mammalian Cells and In-situ Study of Cytoskeletal Mechanics

    NASA Astrophysics Data System (ADS)

    Ma, Zili

    Since the first optical microscope invented by Anton van Leeuwenhoek in 1674, the great development of laser technique and its applications in biophotonics have helped us reveal the mechanisms underlying numerous biological activities gradually. The introduction of fs lasers to the studies of biology has emerged as a fast developing area calling for the efforts and skills both from optics and electric engineering and biology and medicine. Due to the fast update of laser source techniques, there has been an increasing number of commercialized fs lasers available for this growing market of biophotonics. To better utilize the potential offered by fs lasers, we studied the technique of optical gene delivery and tried to narrow the gap between laboratorial research and industrial/clinical applications, in that the strict experimental conditions of specific optical laboratorial studies are generally not appropriate for the practical biological applications. To carry out our experiments, we built a two-stage amplifier fs laser system to generate the desired pulse train. The laser pulse train was coupled into an invert fluorescence microscope for the imaging and manipulation of each cell. To overcome limitations brought by the tight focus of laser beam due to high NA objective, we introduced gold nanorods (GNRs), a metallic nanomaterial, with tunable optical property. With these additional membrane for membrane permeabilization, which could significantly improve the manipulation speed than that based on the tightly focused laser. We used GFP plasmid to demonstrate the applications of this technique in gene delivery, and successfully transfected and GFP-expressed cells were observed one day after the optical transfection. Additionally, as an important trend of biophotonics, the integration of optics with microfluidic chips has become the new frontier of both biology and engineering. Here we firstly demonstrated a technique of gene delivery by an on-chip device generating

  16. PREFACE: ARENA 2006—Acoustic and Radio EeV Neutrino detection Activities

    NASA Astrophysics Data System (ADS)

    Thompson, Lee

    2007-06-01

    The International Conference on Acoustic and Radio EeV Neutrino Activities, ARENA 2006 was jointly hosted by the Universities of Northumbria and Sheffield at the City of Newcastle Campus of the University of Northumbria in June 2006. ARENA 2006 was the latest in a series of meetings which have addressed, either separately or jointly, the use of radio and acoustic sensors for the detection of highly relativistic particles. Previous successful meetings have taken place in Los Angeles (RADHEP, 2000), Stanford (2003) and DESY Zeuthen (ARENA 2005). A total of 50 scientists from across Europe, the US and Japan attended the conference presenting status reports and results from a number of projects and initiatives spread as far afield as the Sweden and the South Pole. The talks presented at the meeting and the proceedings contained herein represent a `snapshot' of the status of the fields of acoustic and radio detection at the time of the conference. The three day meeting also included two invited talks by Dr Paula Chadwick and Dr Johannes Knapp who gave excellent summaries of the related astroparticle physics fields of high energy gamma ray detection and high energy cosmic ray detection respectively. As well as a full academic agenda there were social events including a Medieval themed conference banquet at Lumley Castle and a civic reception kindly provided by the Lord Mayor of Newcastle and hosted at the Mansion House. Thanks must go to the International Advisory Board members for their input and guidance, the Local Organising Committee for their hard work in bringing everything together and finally the delegates for the stimulating, enthusiastic and enjoyable spirit in which ARENA 2006 took place. Lee Thompson

    International Advisory Board

    G. Anton, ErlangenD. Besson, Kansas
    J. Blümer, KarlsruheA. Capone, Rome
    H. Falcke, BonnP. Gorham, Hawaii
    G. Gratta

  17. Igneous composition vaiations determined by ChemCam along Curiosity's traverse from Bradbury to Rocknest area at Gale crater, Mars

    NASA Astrophysics Data System (ADS)

    Sautter, Violaine; MSL Science Team

    2013-04-01

    Since landing in Gale Crater (-4.59, 137,44°) the rover Curiosity, has driven during the first 90 sols, 420 meter east descending ∼ 20m from the Bradbury Landing site towards Glenelg. From sols 13 on, the ChemCam instrument suite performed compositional and imaging analyses of rocks and soils along the route. Each Chem- Cam LIBS observations covers a spot between 350 and 550 μm dia thus individual observations generally do not represent the whole rock composition but rather represent individual grains or a mixture thereof. Most of observations consist of a linear 5-point raster or a 3 x 3 grid. All major elements were regularly reported together with minor and trace elements. During the traverse, two distinct zones have been characterized: Zone I, from sol 0 to sol 47 (i.e. 280 meter traverse), belongs to the Humocky terrains supposed to be a part of the alluvial fan below Peace Vallis, which descends from the crater rim to the Northwest. It is defined by abundant gravels and igneous float rocks and isolated conglomerate outcrops. Rock textures indicate a high ratio of intrusive over extrusive: plutonic rocks vary from homogenous grain size either coarse (1-3mm grains Mara) or fine grained (less than 300 m Coronation) to variable grain size within a given rock (Jake-M). Some contain abundant laths of whitish minerals. ChemCam analyses are Si-rich (up to 60% wt.% or more) together with high Al (more than 15%) and high alkali (Na > K) in a range expected for alkali feldspar compositions. The lowest Si content correlates with low Al and high Fe consistent with ferromagnesian composition. The highest Si content (Stark a white vesicular rock) could indicate the presence of quartz. Clasts analyzed in one conglomerate (Link) had a range of compositions dominated by feldspathic material consistent with loose pebbles in the area and igneous porphyroblast. Beyond Anton soil (sol48), Curiosity entered zone II, transitional to a more distal unit with respect to the fan

  18. Magmatic Vapor Phase Transport of Copper in Reduced Porphyry Copper-Gold Deposits: Evidence From PIXE Microanalysis of Fluid Inclusions

    NASA Astrophysics Data System (ADS)

    Rowins, S. M.; Yeats, C. J.; Ryan, C. G.

    2002-05-01

    Nondestructive proton-induced X-ray emission (PIXE) studies of magmatic fluid inclusions in granite-related Sn-W deposits [1] reveal that copper transport out of reduced felsic magmas is favored by low-salinity vapor and not co-existing high-salinity liquid (halite-saturated brine). Copper transport by magmatic vapor also has been documented in oxidized porphyry Cu-Au deposits, but the magnitude of Cu partitioning into the vapor compared to the brine generally is less pronounced than in the reduced magmatic Sn-W systems [2]. Consideration of these microanalytical data leads to the hypothesis that Cu and, by inference, Au in the recently established "reduced porphyry copper-gold" (RPCG) subclass should partition preferentially into vapor and not high-salinity liquid exsolving directly from fluid-saturated magmas [3-4]. To test this hypothesis, PIXE microanalysis of primary fluid inclusions in quartz-sulfide (pyrite, pyrrhotite & chalcopyrite) veins from two RPCG deposits was undertaken using the CSIRO-GEMOC nuclear microprobe. PIXE microanalysis for the ~30 Ma San Anton deposit (Mexico) was done on halite-saturated aqueous brine (<10 vol.% vapor) and co-existing low-salinity aqueous vapor (<20 vol.% liquid) inclusions. Results indicate that vapor inclusions have higher concentrations of Cu (typically 1000's of ppm; max. 7277 ppm) compared to brine inclusions (typically 100's of ppm). Brine inclusions also are much higher in Cl (Na), K, Ca, Mn, Zn, and Fe. Only Pb concentrations approach those in the vapor. Metal ratios such as Cu/Fe and Cu/Zn are 2 to 167 times higher in the vapor compared with the brine inclusions. Cu/Pb ratios are 2 to 15 times higher in the vapor than in the brine. PIXE microanalysis for the ~617 Ma 17 Mile Hill deposit (W. Australia) was done on halite-saturated "aqueous" inclusions, which contain a small (<10 vol.%) bubble of carbonic fluid, and adjacent "carbonic" inclusions, which have a thin rim of aqueous liquid (<10 vol.%) wetting the

  19. Visions of Discovery

    NASA Astrophysics Data System (ADS)

    Chiao, Raymond Y.; Cohen, Marvin L.; Leggett, Anthony J.; Phillips, William D.; Harper, Charles L., Jr.

    2010-10-01

    physics? Steven Chu; 20. Quantum information J. Ignacio Cirac; 21. Emergence in condensed matter physics Marvin L. Cohen; 22. Achieving the highest spectral resolution over the widest spectral bandwidth: precision measurement meets ultrafast science Jun Ye; 23. Wireless non-radiative energy transfer Marin Soljačić; Part V. Consciousness and Free Will: 24. The big picture: exploring questions on the boundaries of science - consciousness and free will George F. R. Ellis; 25. Quantum entanglement: from fundamental questions to quantum communication and quantum computation and back Anton Zeilinger; 26. Consciousness, body, and brain: the matter of the mind Gerald M. Edelman; 27. The relation between quantum mechanics and higher brain functions: lessons from quantum computation and neurobiology Christof Koch and Klaus Hepp; 28. Free will and the causal closure of physics Robert C. Bishop; 29. Natural laws and the closure of physics Nancy L. Cartwright; 30. Anti-Cartesianism and downward causation: reshaping the free-will debate Nancey Murphy; 31. Can we understand free will? Charles H. Townes; Part VI. Reflections on the Big Questions: Mind, Matter. Mathematics, and Ultimate Reality: 32. The big picture: exploring questions on the boundaries of science - mind, matter, mathematics George F. R. Ellis; 33. The mathematical universe Max Tegmark; 34. Where do the laws of physics come from? Paul C. W. Davies; 35. Science, energy, ethics, and civilization Vaclav Smil; 36. Life of science, life of faith William T. Newsome; 37. The science of light and the light of science: an appreciative theological reflection on the life and work of Charles Hard Townes Robert J. Russell; 38. Two quibbles about 'ultimate' Gerald Gabrielse; Index.

  20. PREFACE: The Universe under the Microscope: Astrophysics at High Angular Resolution

    NASA Astrophysics Data System (ADS)

    Schödel, Rainer

    2009-01-01

    Köln, Köln, Germany Eduardo Ros Max-Planck-Institut für extraterrestrische Physik, Bonn, Germany Scientific organizing committee Dennis Downes Institut de Radio Astronomie Millimétrique, France Wolfgang Duschl University of Kiel, Germany Andrea Ghez University of California, Los Angeles, USA Vladimir Karas Academy of Sciences, Czech Republic Andreas Eckart University of Cologne, Germany Sera Marko University of Amsterdam, The Netherlands Susanne Pfalzner University of Cologne, Germany Sebastian Rabien Max-Planck-Institute for Extraterrestrial Physics, Germany Daniel Rouan Observatoire de Paris-Meudon, France Eduardo Ros Max-Planck-Institute for Radio Astronomy, Germany Rainer Schödel Instituto de Astrofísica de Andalucía -CSIC, Spain Zhiqiang Shen Shanghai Astronomical Observatory, China Anton Zensus Max-Planck-Institute for Radio Astronomy, Germany Local organizing committee Sebastian Fischer University of Cologne, Germany Devaky Kunneriath University of Cologne, Germany Leo Meyer University of Cologne, Germany Koraljka Muzic University of Cologne, Germany Rainer Schödel University of Cologne, Germany/IAA -CSIC, Spain Christian Straubmeier University of Cologne, Germany Mohammad Zamaninasab University of Cologne, Germany

    1. The blind protocol and its place in consciousness research.

      PubMed

      Schwartz, Stephan A

      2005-07-01

      This paper describes the development of the blind protocol, and its place in this history of consciousness research. It was first devised by Croesus, King of the Lydians (BCE 560-547) and reported by Herodotus ( approximately BCE 484 - approximately 424), and was created to protect against fraud in assessing an Anomalous Perception (AP) event; a Remote Viewing (RV) experiment little different from those conducted today. Its next use in the 17th century was to study a peasant farmer, Jacques Aymar, who solved crimes with Anomalous Perception, using dowsing. Not only was a blind protocol employed, but the rudiments of controls were introduced to assess Aymar. The next documented use of a blind protocol in consciousness research occurred in 1784, when it was explicitly employed in the interest of science, and its history as a research technique can be said to have formally begun. King Louis the XVIth created a commission to evaluate Franz Anton Mesmer's claims concerning healing through "animal magnetism," administered while people were in a trance, and asked Benjamin Franklin to be the commission's head. The paper proposes that Franklin be considered the first parapsychologist. He created the blind protocol to answer the king's question as to whether "animal magnetism" was real, and he not only introduced demographic variables and controls, but literally blindfolded people, which is why today we call it the blind protocol. Franklin's observations also present the first recorded Western description of psychosomatic illness. An unintended consequence of Franklin's Mesmer study was the loss of the idea of psychophysical self-regulation (PPSR) as a research vector, although the English surgeon John Eliotson (1791-1868) apparently saw through the failure of Mesmer's explanatory model to the deeper insight in the form of hypnosis that was Mesmer's real discovery. He seems to have avoided all attempts at explaining how it worked but conducted a considerable number of

    2. FOREWORD: The XXV IAHR Symposium on Hydraulic Machinery and Systems marks half a century tradition

      NASA Astrophysics Data System (ADS)

      Susan-Resiga, Romeo

      2010-05-01

      'Politehnica' of Timisoara in 1923 'It is not the walls that make a school, but the spirit living inside'. A particular trademark of the 'Politehnica' of Timisoara was the continuous effort to answer industrial problems by training the students not only on theoretical aspects but also in design and manufacturing, as well as in laboratory works. Developing modern laboratories, where students can observe and understand first hand the engineering applications along the years a priority for Timisoara 'Politehnica' University. The School of Hydraulic Machinery within the 'Politehnica' University of Timisoara was established in early 1930 by Professor Aurel Barglazan (1905-1960), and further developed by Professor Ioan Anton (born 1924), both members of the Romanian Academy. The Laboratory of Hydraulic Machines from Timisoara (LMHT) started back in 1928 in a small hut, with a test rig for Francis and Kaplan turbines manufactured by J M Voith. LMHT was continuously developed and was officially recognized in 1959 as being one of the leading research and developing laboratories in Romania. It was the foundation of the Romanian efforts of designing and manufacturing hydraulic turbines starting in 1960 at the Resita Machine Building Factory. Under the leadership of Professor Ioan Anton, the Timisoara School in Hydraulic Machinery has focused the basic and development research activities on the following main topics: (i) Turbine Hydrodynamics, (ii) Hydrofoil Cascade Hydrodynamics, (iii) Cavitation in Hydraulic Machines and Equipments, (iv) Scale-up Effects in Hydraulic Machines. With the establishment in the year 2000 of the National Center for Engineering of Systems with Complex Fluids, within the 'Politehnica' University of Timisoara, the research in turbomachinery hydrodynamics and cavitation included high performance computing for flows in hydraulic machines, as well as the development of novel technologies to mitigate the self-induced flow instabilities in hydraulic turbines operated

    3. [Difficulties of genetic counselling in rare, mainly neurogenetic disorders].

      PubMed

      Horváth, Emese; Nagy, Nikoletta; Széll, Márta

      2014-08-01

      Bevezetés: A genetikai vizsgálómódszerek fejlődésének köszönhetően az elmúlt évtizedekben számos ritka kórkép genetikai háttere került felderítésre. Célkitűzés: A szerzők célul tűzték ki öt ritka, elsősorban neurogenetikai kórképben szenvedő beteg genetikai tanácsadása és vizsgálata során felmerülő nehézségek bemutatását. Módszer: A preteszt genetikai tanácsadás során a tünetek alapján felmerülő kórképről és a rendelkezésre álló genetikai vizsgálómódszerekről történt tájékoztatás. Az elvégzett citogenetikai és molekuláris biológiai vizsgálatok eredményeit posztteszt genetikai tanácsadás keretében ismertették. Eredmények: A bemutatott öt különböző ritka neurogenetikai kórképben szenvedő betegnél három esetben sikerült azonosítani a háttérben álló kóroki genetikai eltérést, míg két esetben az elvégzett genetikai vizsgálatokkal citogenetikai, illetve molekuláris genetikai eltérést nem tudtak kimutatni. Következtetések: Habár egyre hatékonyabb genetikai vizsgálómódszerek állnak rendelkezésre, a kóroki genetikai eltérés azonosítása manapság sem történik meg minden esetben. A vizsgálati eredmények kiértékelésében és interpretálásában óriási szerepe van a klinikai genetikusnak, aki tájékoztatást ad a betegségről és segít a családtervezésben Orv. Hetil., 2014, 155(31), 1221–1227.

    4. [What motivates smoking and alcohol drinking of young people? A behavioural epidemiologic study].

      PubMed

      Pikó, Bettina; Varga, Szabolcs

      2014-01-19

      Bevezetés: A serdülőkor a káros szenvedélyt okozó szerek kipróbálásának időszaka. A prevencióhoz segítséget nyújthat a fiatalok motivációinak ismerete. Célkitűzés: A szerzők középiskolás fiatalok dohányzással és alkoholfogyasztással kapcsolatos motivációinak vizsgálatát tűzték ki célul. Módszer: Kérdőíves adatfelvételre Debrecenben négy középiskola tanulóinak bevonásával került sor (n = 501; életkor: 14–22 év között; átlagéletkor 16,4 év; 34% fiú és 66% lány). A leíró statisztikán túl logisztikus regresszióelemzéssel állapították meg a szerfogyasztás és a motivációk közötti összefüggéseket jelző esélyhányadosokat. Eredmények: Nemenként alig, szerfogyasztási státus szerint viszont jelentős különbségek voltak a motivációs struktúrában. Az alkoholfogyasztás esetében a társas motiváció bizonyult prediktornak. A cigaretta esetében azonban nemcsak a társas hatások szerepe igazolódott, hanem az unaloműzés és az érzelmi reguláció (coping) jelentősége is. Következtetések: Az eredmények azt sugallják, hogy a fiatalok társas környezetben, kortársaik hatására kezdenek el cigarettázni és alkoholt fogyasztani. A prevenciós stratégiáknak ezért elsősorban a szociális készségek fejlesztésére kell épülniük. Orv. Hetil., 2014, 155(3), 100–105.

    5. Emission Measurements of Lunar Analogues Measured in a Simulated Lunar Environment for Interpretation of Data Returned from the Diviner Lunar Radiometer on NASA’s Lunar Reconnaissance Orbiter

      NASA Astrophysics Data System (ADS)

      Thomas, I. R.; Bowles, N. E.; Greenhagen, B. T.; Paige, D. A.

      2009-12-01

      analogue minerals in the laboratory, by heating the minerals to ~400K while they are surrounded by a shroud cooled to ~120K by liquid nitrogen, all in a vacuum of <10^(-4)mbar. The simulator is attached to a Brüker IFS66v Fourier Transform Spectrometer at the University of Oxford. This setup is capable of measuring emission spectra in a simulated lunar environment from the mid to far-infrared of a wide range of minerals of various grain size distributions. This presentation includes the minerals albite, andesine, anorthite, augite, bytownite, diopside, enstatite, fayalite, forsterite, ilmenite, quartz etc, and several mineral mixtures. References: [1] Greenhagen B.T. & Paige D.A.(2009) LPS XL; [2] Paige, D.A. et al.(2009) Space Sci.Rev.; [3] Greenhagen B.T. & Paige D.A.(2006) LPS XXXVII; [4] Murcray F.H. et al.(1970) JGR, 75; [5] Lucey P.G.(1991) LPS XXI; [6] Salisbury J.W. & Walter L.S.(1989) JGR, 94; [7] Cooper B.L. et al.(2002) JGR, 107; [8] Logan L.M. & Hunt G.R.(1970) Science, 169; [9] Logan L.M. et al.(1973) JGR, 79; [10] Henderson B.G. et al.(1996) JGR, 101; [11]Henderson B.G. & Jakosky B.M.(1997) JGR, 102; [12]Nash D.B. et al.(1993) JGR, 98

    6. Inferred paleotectonic settings and paleogeography at 500-450 Ma based on geochemical evaluation of Ordovician volcanics and gabbros of the Upper Allochthon, Mid Norway

      NASA Astrophysics Data System (ADS)

      Hollocher, K.; Roberts, D.; Robinson, P.; Walsh, E.

      2012-04-01

      Evaluation of major- and trace-element analyses of Ordovician volcanics and gabbros from the Støren Nappe of the Upper Allochthon, Mid Norway, including 87 new analyses, covers the Late Cambrian-earliest Ordovician ophiolite complexes and overlying Ordovician volcanics. The older rocks have mainly MORB-like compositions likely formed in a back-arc basin, plus less abundant oceanic-arc basalts and andesites. Compositions characteristic of fore-arc environments are absent. The Upper Allochthon has three elements: A) The Gula Nappe of probable Cambrian and Tremadocian, epicontinental sedimentary rocks, B) The Støren and Meråker nappes with their basal suprasubduction-zone ophiolitic volcanics and intrusions plus younger Ordovician successions, C) In northwestern parts of the Støren Nappe, a complex of predominantly calc-alkaline arc intrusive rocks 482 to 441 Ma. The structural and stratigraphic history indicates obduction of ophiolites occurred at 480-475 Ma soon after formation, followed by uplift, erosion, and deposition of conglomerates incorporating ophiolite debris. The overlying sequence includes shelly Toquima-Table Head faunas of Laurentian affinity and younger strata into Upper Ordovician. Field relations suggest that the ophiolites were obducted onto rocks of the Gula Complex. A Tremadocian, graptolite-bearing black shale/phyllite in the eastern part of the Gula has close geochemical affinities with the reducing V- and U-enriched Alum shale of the Baltoscandian margin, black shales in the lower Köli nappes of the Upper Allochthon in Sweden, and similar shales in the Gander and Avalon zones of Maritime Canada. Such shales originated in high-latitude (40-50° south) cool-water environments, as existed in Late Cambrian-earliest Ordovician Baltica, Avalonia, and Ganderia, and have not been recorded in equatorial paleolatitudes, such as the earliest Ordovician margin of Laurentia. Our paleotectonic account for these features is in three time slices: 1) A

    7. [Report of the 2013 data of the Hungarian Vascular Registry].

      PubMed

      Szeberin, Zoltán; Hidi, László; Kováts, Tamás; Menyhei, Gábor

      2014-12-01

      Bevezetés: Az orvostudomány a ’90-es években a modern informatika eszközeinek előnyeit felismerve adatbázisokat hozott létre megfigyeléseinek rögzítése céljából. Magyarországon 2002-ben hozták létre az Érsebészeti Regisztert, egy carotis-, aneurysma- és alsó végtagi artériás műtéteket feldolgozó adatbázist. A Magyar Angiológiai és Érsebészeti Társaság vezetősége azt a célt tűzte ki, hogy a regiszter adatait rendszeresen feldolgozza. Jelen cikkben az Érsebészeti Regiszterben rögzített 2013. évi érműtétek fontosabb eredményeit mutatjuk be. Eredmények: Összesen 3916 érsebészeti eset került rögzítésre, 25,36%-ban carotis-, 10,11%-ban aneurysma- és 64,53%-ban alsó végtagi érműtét történt. Az esetek 23,90%-ában akut, 76,10%-ában electiv beavatkozást végeztek. A műtétet igénylő érbetegségek szempontjából a 60-70 éves korosztály a legveszélyeztetettebb, bár alsó végtagi érrekonstrukció gyakran szükséges fiatalabb korban is. A hasi aortaaneurysma-műtétek 31,47%-a stentgraft-implantáció volt, míg 68,53%-ban nyitott műtétet végeztek. A műtétet indokoló aneurysmák átlagos átmérője 62,45 ± 12,05 mm volt. Az aortaaneurysma-műtétek halálozási aránya 7,57%, az alsó végtagi műtéteké 2,06%, a carotisműtétek mortalitás-stroke előfordulási aránya 2,62% volt. Következtetések: A regiszterek gyakorlati haszna egyértelmű azokban az országokban, ahol magas színvonalon alkalmazzák azokat, és éves jelentésekkel segítik az érsebészet szakmai hatékonyságát. Közös érdekünk egy jól működő hazai adatbázis hosszú távú fenntartása.

    8. A foundation monograph of Convolvulus L. (Convolvulaceae)

      PubMed Central

      Wood, John R.I.; Williams, Bethany R.M.; Mitchell, Thomas C.; Carine, Mark A.; Harris, David J.; Scotland, Robert W.

      2015-01-01

      Abstract A global revision of Convolvulus L. is presented, Calystegia R.Br. being excluded on pragmatic grounds. One hundred and ninety species are recognised with the greatest diversity in the Irano-Turanian region. All recognised species are described and the majority are illustrated. Distribution details, keys to species identification and taxonomic notes are provided. Four new species, Convolvulus austroafricanus J.R.I.Wood & R.W.Scotland, sp. nov., Convolvulus iranicus J.R.I.Wood & R.W.Scotland, sp. nov., Convolvulus peninsularis J.R.I.Wood & R.W.Scotland, sp. nov. and Convolvulus xanthopotamicus J.R.I.Wood & R.W.Scotland, sp. nov., one new subspecies Convolvulus chinensis subsp. triangularis J.R.I.Wood & R.W.Scotland, subsp. nov., and two new varieties Convolvulus equitans var. lindheimeri J.R.I.Wood & R.W.Scotland, var. nov., Convolvulus glomeratus var. sachalitarum J.R.I.Wood & R.W.Scotland, var. nov. are described. Convolvulus incisodentatus J.R.I.Wood & R.W.Scotland, nom. nov., is provided as a replacement name for the illegitimate Convolvulus incisus Choisy. Several species treated as synonyms of other species in recent publications are reinstated including Convolvulus chinensis Ker-Gawl., Convolvulus spinifer M.Popov., Convolvulus randii Rendle and Convolvulus aschersonii Engl. Ten taxa are given new status and recognised at new ranks: Convolvulus namaquensis (Schltr. ex. A.Meeuse) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus hermanniae subsp. erosus (Desr.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus crenatifolius subsp. montevidensis (Spreng.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus fruticulosus subsp. glandulosus (Webb) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus capituliferus subsp. foliaceus (Verdc.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus hystrix subsp. ruspolii (Dammer ex Hallier f.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus hystrix subsp. inermis (Chiov.) J.R.I.Wood & R.W.Scotland, stat. nov

    9. Detrital Zircon Signatures of the Baltoscandian Margin in the central Scandes

      NASA Astrophysics Data System (ADS)

      Gee, D. G.; Ladenberger, A.; Dahlqvist, P.; Frei, D.

      2012-04-01

      An on-going project seeks to establish the provenance signatures along the Baltoscandian margin, from central Jämtland in Sweden to Finnmark in northern Norway, by LA-ICPMS U/Pb analysis of detrital zircons in siliciclastic (meta-)sediments in the various nappes of the Lower and Middle allochthons (including the Seve Nappe Complex, SNC; Andreasson and Gee 2008, 33rd IGC Oslo) of the Scandinavian Caledonides. In the western central Jämtland -Tröndelag profile of the central Scandes, the detrital zircons provide evidence of the change in character of the Baltoscandian crystalline basement, from the characteristic late Paleoproterozoic granites of the Trans-Scandinavian Igneous Belt (TIB, c.1650-1850Ma) in the autochthon, to the typical Mesoproterozoic age profile (c.950-1700Ma) of the Sveconorwegian Orogen of southwestern Scandinavia in the hinterland. In the autochthon, the Cambrian alum shales rest directly on late TIB basement, but in the overlying, low grade Jämtlandian Nappes of the Lower Allochthon, these shales are underlain by Early Cambrian (possibly Late Ediacaran) Vemdal quartzites; they provide strong bimodal signatures with TIB (1700-1800) and Sveconorwegian, sensu stricto (950-1000Ma) ages dominant. This signature persists in these formations, at the same tectonostratigraphic level, westwards into Tröndelag, via Trollheimen to the Norwegian west coast. Ordovician turbidites (Norråker Formation) of the Lower Allochthon in Sweden, sourced from the west, have unimodal signatures dominated by Sveconorwegian (sensu stricto) signatures with peaks at 1000-1100Ma, but with subordinate components of older Meoproterozoic zircons (1200-1650Ma). Younger sandstones in the Jämtlandian Nappes are being analysed. In the greenschist facies Middle Allochthon, the Särv Nappe signatures (Béeri-Shlevin et al 2011, Precambrian Research) are mostly bimodal (950-1100Ma and 1700-1850Ma), with variable dominance of the younger or older group and subordinate other

    10. [Clinical experiences with basal analogue insulin in routine care. Retrospective follow up analysis of a database from daily routine care].

      PubMed

      Sudár, Zsolt; Muth, Lajos; Nyirati, Csaba; Szí, Vince; Tornóczky, János; Ulrich, Gabriella

      2013-09-15

      Bevezetés: 2-es típusú cukorbetegségben egyre gyakrabban kerül alkalmazásra a bázis-bolus inzulinkezelési rendszer, az anyagcserekontroll javítása és a szövődmények kockázatának csökkentése érdekében. Napjaink kérdése, hogy az inzulinanalógok alkalmazása milyen gyakorlati változásokat hoz a humán inzulinkezelési rendszerekhez képest. Célkitűzés: A szerzők retrospektív adatelemzéssel vizsgálták a teljes humán bázis-bolus kezelésről teljes inzulinanalóg-kezelésre váltás hatásait az anyagcserehelyzetre, a testsúlyra, az inzulindózisokra és a bázis-bolus inzulin arányra. Módszer: Olyan 2-es típusú cukorbetegeket (n = 137) vontak be a vizsgálatba, akik napi egyszeri bázisinzulint használtak a főétkezésekhez adott gyors hatású inzulinok mellett, és a humán inzulinokról analóg inzulinokra cserélték a gyógyszerüket. A betegeket detemirt (n = 103) és glargint (n = 34) használó csoportokba sorolták. Eredmények: Tizenhét hónapos inzulinanalóg-terápia során a HbA1c 0,34%-kal csökkent (detemir: –0,44%; glargin: –0,17%). A testsúly 1,11 kg-mal növekedett (detemir: +1,0 kg; glargin: +1,43 kg). A bázisinzulin aránya minden esetben emelkedett (teljes populáció: 6,04%, detemir: 5,26%, glargin: 8,37%). Az átlagos inzulindózis a vizsgálat végén 80,76 egység volt, és nem volt szignifikáns különbség sem a bázis-, sem a teljes inzulindózisokat illetően a detemir- (27,89 E, illetve 79,78 E) és a glargin- (32,85 E, 83,74 E) csoportok között. Következtetések: Az adatok alátámasztják, hogy a humánról analóg inzulinra történő váltáskor, bázis-bolus kezelési rendszerben a bázisinzulin dózisának emelésével, a bázis/bolus arány növelésével javítható az anyagcserekontroll. A detemir- és glarginalapú terápia hasonló anyagcserekontroll-javulás mellett azonos inzulindózisokkal járt, és valamelyest több testsúlynövekedéssel a glargincsoportban. Orv. Hetil

    11. EDITORIAL: Focus on Quantum Cryptography: Theory and Practice FOCUS ON QUANTUM CRYPTOGRAPHY: THEORY AND PRACTICE

      NASA Astrophysics Data System (ADS)

      Lütkenhaus, N.; Shields, A. J.

      2009-04-01

      descriptions and are based on observable tests during the run of QKD sessions. It is now 25 years since the first proposal for QKD was published and 20 since the first experimental realization. The intervening years have brought several technological and theoretical advances, which have driven new insights into the application of quantum theory to the wider field of information technology. We are looking forward to the new twists and turns this field will take in the next 25 years! Focus on Quantum Cryptography: Theory and Practice Contents Security of continuous-variable quantum key distribution: towards a de Finetti theorem for rotation symmetry in phase space A Leverrier, E Karpov, P Grangier and N J Cerf Optical networking for quantum key distribution and quantum communications T E Chapuran, P Toliver, N A Peters, J Jackel, M S Goodman, R J Runser, S R McNown, N Dallmann, R J Hughes, K P McCabe, J E Nordholt, C G Peterson, K T Tyagi, L Mercer and H Dardy Proof-of-concept of real-world quantum key distribution with quantum frames I Lucio-Martinez, P Chan, X Mo, S Hosier and W Tittel Composability in quantum cryptography Jörn Müller-Quade and Renato Renner Distributed authentication for randomly compromised networks Travis R Beals, Kevin P Hynes and Barry C Sanders Feasibility of 300 km quantum key distribution with entangled states Thomas Scheidl, Rupert Ursin, Alessandro Fedrizzi, Sven Ramelow, Xiao-Song Ma, Thomas Herbst, Robert Prevedel, Lothar Ratschbacher, Johannes Kofler, Thomas Jennewein and Anton Zeilinger Decoy-state quantum key distribution with both source errors and statistical fluctuations Xiang-Bin Wang, Lin Yang, Cheng-Zhi Peng and Jian-Wei Pan High rate, long-distance quantum key distribution over 250 km of ultra low loss fibres D Stucki, N Walenta, F Vannel, R T Thew, N Gisin, H Zbinden, S Gray, C R Towery and S Ten Topological optimization of quantum key distribution networks R Alléaume, F Roueff, E Diamanti and N Lütkenhaus The SECOQC quantum key

    12. The Secret Lives Of Galaxies Unveiled In Deep Survey

      NASA Astrophysics Data System (ADS)

      2003-06-01

      South This increase in galaxy size is consistent with "bottom-up" models, where galaxies grow hierarchically, through mergers and accretion of smaller satellite galaxies. This is also consistent with the idea the sizes of galaxies match hand-in-glove to a certain fraction of the sizes of their dark-matter halos. Dark matter is an invisible form of mass that comprises most of the matter in the universe. The theory is dark matter essentially pooled into gravitational "puddles" in the early universe, then collected normal gas that quickly contracted to build star clusters and small galaxies. These dwarf galaxies merged piece-by-piece over billions of years to build the immense spiral and elliptical galaxies we see today. The Chandra observations amounted to a "high-energy core sample" of the early universe, allowing us to "study the history of black holes over almost the entire age of the universe," said Niel Brandt of Penn State University, a co-investigator on the Chandra GOODS team. One of the fascinating findings in this deepest X-ray image ever taken is the discovery of mysterious black holes, which have no optical counterparts. "We found seven mysterious sources that are completely invisible in the optical with Hubble," said Anton Koekemoer of the STScI, a co-investigator on both the Hubble and Chandra GOODS teams. "Either they are the most distant black holes ever detected, or they are less distant black holes that are the most dust enshrouded known, a surprising result as well." When comparing the HST and Chandra fields, astronomers also found active black holes in distant, relatively small galaxies were rarer than expected. This may be due to the effects of early generations of massive stars that exploded as supernovae, evacuating galactic gas and thus reducing the supply of gas needed to feed a super massive black hole. These and other results from the GOODS project will be published in a special issue of the Astrophysical Journal Letters, entirely devoted to the

    13. PREFACE: International Conference on Topics in Astroparticle and Underground Physics (TAUP 2011)

      NASA Astrophysics Data System (ADS)

      Oberauer, Lothar; Raffelt, Georg; Wagner, Robert

      2012-07-01

      The 12th edition of the International Conference on Topics in Astroparticle and Underground Physics (TAUP 2011) was held 5-9 September 2011 in Munich (and for the first time in Germany). It was organized by the Max Planck Institute for Physics (MPP), the Technical University Munich (TUM) and the Cluster of Excellence 'Origin and Structure of the Universe'. The conference was held in the 'Künstlerhaus', a traditional downtown location for artistic festivities. The meeting attracted 317 participants (61 of which were women) from 29 countries, see figure below. The topics covered by the meeting were Cosmology and particle physics, Dark matter and its detection, Neutrino physics and astrophysics, Gravitational waves and High-energy astrophysics and cosmic rays, and the various interfaces between these areas. The scientific sessions consisted of five mornings of plenary talks, four afternoons of parallel sessions, and an evening poster session. The co-founder of the conference series, Alessandro Bottino, has decided to retire from the position of chairman of the TAUP Steering Committee after the completion of TAUP 2011. On behalf of all followers of this series, we thank him for having started these inspiring events and his many years of dedicated service. We thank all speakers, conveners and participants as well as the members of the organizing, steering and international advisory committee for making this a successful and memorable meeting. Lothar Oberauer, Georg Raffelt, Robert Wagner Proceedings editors Figure Committees International Advisory Committee G AntonUniversity of Erlangen E AprileColumbia University M Baldo-CeolinUniversity of Padova R BattistonUniversity of Perugia & INFN L BergströmUniversity Stockholm R BernabeiUniversity of Rome 'Tor Vergata' A BettiniLSC Canfranc P BinetruyAPC Paris J BlümerKarlsruhe Institute of Technology B CabreraStanford University A CaldwellMax Planck Institute for Physics M ChenQueens University E CocciaUniversity of Rome

    14. Committees

      NASA Astrophysics Data System (ADS)

      2012-11-01

      Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

    15. PREFACE: EmerQuM 11: Emergent Quantum Mechanics 2011 (Heinz von Foerster Congress)

      NASA Astrophysics Data System (ADS)

      Grössing, Gerhard

      2012-05-01

      These proceedings comprise the plenary lectures and poster contributions of the 'Heinz von Foerster Conference 2011' on Emergent Quantum Mechanics (EmerQuM11), which was held at the University of Vienna, 11-13 November 2011. With the 5th International Heinz von Foerster Conference convened at the occasion of von Foerster's 100th birthday, the organizers opted for a twin conference to take place at the Large and Small Ceremonial Halls of the University's main building, respectively. The overall topic was chosen as 'Self-Organization and Emergence', a topic to which von Foerster was an early contributor. While the first conference ('Self-Organization and Emergence in Nature and Society') addressed a more general audience, the second one ('Emergent Quantum Mechanics') was intended as a specialist meeting with a contemporary topic that could both serve as an illustration of von Foerster's intellectual heritage and, more generally, point towards future directions in physics. We thus intended to bring together many of those physicists who are interested in or are working on attempts to understand quantum mechanics as emerging from a suitable classical (or, more generally, deeper level) physics. EmerQuM11 was organized by the Austrian Institute for Nonlinear Studies (AINS), with essential support from the Wiener Institute for Social Science Documentation and Methodology (WISDOM), the Department of Contemporary History at the University of Vienna, and the Heinz von Foerster-Gesellschaft. There were a number of individuals who contributed to the smooth course of our meeting and whom I would like to sincerely thank: Christian Bischof, Thomas Elze, Marianne Ertl, Gertrud Hafner, Werner Korn, Angelika Krawanja, Florian Krug and his team, Sonja Lang, Albert Müller, Ilse Müller, Irene Müller, Karl Müller, Armin Reautschnig, Marion Schirrmacher, Anton Staudinger, Roman Zlabinger, and, last but not least, my AINS colleagues Siegfried Fussy, Herbert Schwabl and Johannes Mesa

    16. PREFACE: EmQM13: Emergent Quantum Mechanics 2013

      NASA Astrophysics Data System (ADS)

      2014-04-01

      these proceedings represent the talks of the invited speakers as written immediately after the symposium. The volume starts with a contribution by organizers Jan Walleczek and Gerhard Grössing, essentially explaining why emergent quantum mechanics, and other deterministic approaches to quantum theory, must be considered viable approaches in quantum foundations today. This is followed by the exposition of Stephen Adler's talk who introduced to a general audience key questions at the current frontiers of quantum mechanics during the opening evening (with the contents of his conference talk appearing elsewhere). The conference proceedings then continues with the presentations as given in their chronological order i.e. starting with the opening talk of the scientific program by Gerard 't Hooft. While the page number was restricted for all invited speakers, the paper by Jeff Tollaksen was given more space, as his invited collaborator Yakir Aharonov was unable to deliver a separate talk, in order to represent both contributions in one paper. Note that the talks of all speakers, including the talks of those who could not be represented in this volume (M. Arndt, B. Braverman, C. Brukner, S. Colin, Y. Couder, B. Poirier, A. Steinberg, G. Weihs and H. Wiseman) are freely available on the conference website as video presentations (http://www.emqm13.org). The organizers wish to express their gratitude to Siegfried Fussy and Herbert Schwabl from AINS for the organizational support. The organizers also wish to thank Bruce Fetzer, President and CEO, John E. Fetzer Memorial Trust, and the Members of the Board of Trustees, for their strong support and for funding this symposium. We also wish to thank the Austrian Academy of Sciences for allowing the symposium to be held on their premises, and Anton Zeilinger, President of the Austrian Academy of Sciences, for his welcome address. The expertise of the Members of the Scientific Advisory Board of the EmQM13 symposium, Ana Maria Cetto

    17. Sensitivity of ocean model simulation in the coastal ocean to the resolution of the meteorological forcing

      NASA Astrophysics Data System (ADS)

      Chen, Feng; Shapiro, Georgy; Thain, Richard

      2013-04-01

      Zatsepin , Valentina Khan, Valery Prostakishin , Tatiana Akivis , Vladimir Belokopytov , Anton Sviridov , and Vladimir Piotukh . 2011. Response of water temperature in the Black Sea to atmospheric forcing: the sensitivity study. Geophysical Research Abstracts. Vol. 13, EGU2011-933

    18. The Secret Lives Of Galaxies Unveiled In Deep Survey

      NASA Astrophysics Data System (ADS)

      2003-06-01

      South This increase in galaxy size is consistent with "bottom-up" models, where galaxies grow hierarchically, through mergers and accretion of smaller satellite galaxies. This is also consistent with the idea the sizes of galaxies match hand-in-glove to a certain fraction of the sizes of their dark-matter halos. Dark matter is an invisible form of mass that comprises most of the matter in the universe. The theory is dark matter essentially pooled into gravitational "puddles" in the early universe, then collected normal gas that quickly contracted to build star clusters and small galaxies. These dwarf galaxies merged piece-by-piece over billions of years to build the immense spiral and elliptical galaxies we see today. The Chandra observations amounted to a "high-energy core sample" of the early universe, allowing us to "study the history of black holes over almost the entire age of the universe," said Niel Brandt of Penn State University, a co-investigator on the Chandra GOODS team. One of the fascinating findings in this deepest X-ray image ever taken is the discovery of mysterious black holes, which have no optical counterparts. "We found seven mysterious sources that are completely invisible in the optical with Hubble," said Anton Koekemoer of the STScI, a co-investigator on both the Hubble and Chandra GOODS teams. "Either they are the most distant black holes ever detected, or they are less distant black holes that are the most dust enshrouded known, a surprising result as well." When comparing the HST and Chandra fields, astronomers also found active black holes in distant, relatively small galaxies were rarer than expected. This may be due to the effects of early generations of massive stars that exploded as supernovae, evacuating galactic gas and thus reducing the supply of gas needed to feed a super massive black hole. These and other results from the GOODS project will be published in a special issue of the Astrophysical Journal Letters, entirely devoted to the

    19. EDITORIAL: Fluctuations and noise in photonics and quantum optics: a special issue in memory of Hermann Haus

      NASA Astrophysics Data System (ADS)

      Abbott, Derek; Shapiro, Jeffrey H.; Yamamoto, Yoshihisa

      2004-08-01

      , USA Peter R Smith Loughborough University of Technology, UK Rodney S Tucker University of Melbourne, Australia Howard M Wiseman Griffith University, Brisbane, Australia Stuart A Wolf DARPA, Arlington, VA, USA Anton Zeilinger University of Vienna, Austria Xi-Cheng Zhang Rensselaer Polytechnic Institute, Troy, NY, USA

    20. PREFACE: ARENA 2006—Acoustic and Radio EeV Neutrino detection Activities

      NASA Astrophysics Data System (ADS)

      Thompson, Lee

      2007-06-01

      The International Conference on Acoustic and Radio EeV Neutrino Activities, ARENA 2006 was jointly hosted by the Universities of Northumbria and Sheffield at the City of Newcastle Campus of the University of Northumbria in June 2006. ARENA 2006 was the latest in a series of meetings which have addressed, either separately or jointly, the use of radio and acoustic sensors for the detection of highly relativistic particles. Previous successful meetings have taken place in Los Angeles (RADHEP, 2000), Stanford (2003) and DESY Zeuthen (ARENA 2005). A total of 50 scientists from across Europe, the US and Japan attended the conference presenting status reports and results from a number of projects and initiatives spread as far afield as the Sweden and the South Pole. The talks presented at the meeting and the proceedings contained herein represent a `snapshot' of the status of the fields of acoustic and radio detection at the time of the conference. The three day meeting also included two invited talks by Dr Paula Chadwick and Dr Johannes Knapp who gave excellent summaries of the related astroparticle physics fields of high energy gamma ray detection and high energy cosmic ray detection respectively. As well as a full academic agenda there were social events including a Medieval themed conference banquet at Lumley Castle and a civic reception kindly provided by the Lord Mayor of Newcastle and hosted at the Mansion House. Thanks must go to the International Advisory Board members for their input and guidance, the Local Organising Committee for their hard work in bringing everything together and finally the delegates for the stimulating, enthusiastic and enjoyable spirit in which ARENA 2006 took place. Lee Thompson

      International Advisory Board

      G. Anton, ErlangenD. Besson, Kansas
      J. Blümer, KarlsruheA. Capone, Rome
      H. Falcke, BonnP. Gorham, Hawaii
      G. Gratta

      1. International Agreement Will Advance Radio Astronomy

        NASA Astrophysics Data System (ADS)

        2007-12-01

        Two of the world's leading astronomical institutions have formalized an agreement to cooperate on joint efforts for the technical and scientific advancement of radio astronomy. The National Radio Astronomy Observatory (NRAO) in the United States and the Max-Planck Institute for Radioastronomy (MPIfR) in Germany concluded a Memorandum of Understanding outlining planned collaborative efforts to enhance the capabilities of each other's telescopes and to expand their cooperation in scientific research. The VLBA The VLBA CREDIT: NRAO/AUI/NSF In the first project pursued under this agreement, the MPIfR will contribute $299,000 to upgrade the continent-wide Very Long Baseline Array's (VLBA) capability to receive radio emissions at a frequency of 22 GHz. This improvement will enhance the VLBA's scientific productivity and will be particularly important for cutting-edge research in cosmology and enigmatic cosmic objects such as gamma-ray blazars. "This agreement follows many years of cooperation between our institutions and recognizes the importance of international collaboration for the future of astronomical research," said Fred K.Y. Lo, NRAO Director. "Our two institutions have many common research goals, and joining forces to keep all our telescopes at the forefront of technology will be highly beneficial for the science," said Anton Zensus, Director at MPIfR. In addition to the VLBA, the NRAO operates the Very Large Array (VLA) in New Mexico and the Robert C. Byrd Green Bank Telescope (GBT) in West Virginia. The MPIfR operates the 100-meter Effelsberg Radio Telescope in Germany and the 12-meter APEX submillimeter telescope in 5100 m altitude in the Cilean Atacama desert (together with the European Southern Observatory and the Swedish Onsala Space Observatory). With the 100-meter telescope, it is part of the VLBA network in providing transatlantic baselines. Both institutions are members of a global network of telescopes (the Global VLBI Network) that uses simultaneous

      2. REPORT OF RESEARCH ACCOMPLISHMENTS AND FUTURE GOALS HIGH ENERGY PHYSICS

        SciTech Connect

        Wise, Mark B.; Kapustin, Anton N.; Schwarz, John Henry; Carroll, Sean; Ooguri, Hirosi; Gukov, Sergei; Preskill, John; Hitlin, David G.; Porter, Frank C.; Patterson, Ryan B.; Newman, Harvey B.; Spiropulu, Maria; Golwala, Sunil; Zhu, Ren-Yuan

        2014-08-26

        of activity include: CDMS II data analysis, contributions to SuperCDMS Soudan operations and analysis, R&D towards SuperCDMS SNOLAB, development of a novel screener for radiocontamination (the BetaCage), and development of new WIMP detector concepts. Ren-Yuan Zhu leads the HEP crystal laboratory for the advanced detector R&D effort. The crystal lab is involved in development of novel scintillating crystals and has proposed several crystal based detector concepts for future HEP experiments at the energy and intensity frontiers. Its current research effort is concentrated on development of fast crystal scintillators with good radiation hardness and low cost. II) THEORETICAL PHYSICS The main theme of Sergei Gukov's current research is the relation between the geometry of quantum group invariants and their categorification, on the one hand, and the physics of supersymmetric gauge theory and string theory, on the other. Anton Kapustin's research spans a variety of topics in non-perturbative Quantum Field Theory (QFT). His main areas of interest are supersymmetric gauge theories, non-perturbative dualities in QFT, disorder operators, Topological Quantum Field Theory, and non-relativistic QFT. He is also interested in the foundations and possible generalizations of Quantum Mechanics. Hirosi Ooguri's current research has two main components. One is to find exact results in Calabi-Yau compactification of string theory. Another is to explore applications of the AdS/CFT correspondence. He also plans to continue his project with Caltech postdoctoral fellows on BPS spectra of supersymmetric gauge theories in diverse dimensions. John Preskill works on quantum information science. This field may lead to important future technologies, and also lead to new understanding of issues in fundamental physics John Schwarz has been exploring a number of topics in superstring theory/M-theory, supersymmetric gauge theory, and their AdS/CFT relationships. Much of the motivation for these

      3. New National Telescope at La Silla - TRAPPIST to Scout the Sky and Uncover Exoplanets and Comets

        NASA Astrophysics Data System (ADS)

        2010-06-01

        Geneva Observatory, Switzerland. The telescope is installed in the building that housed the old Swiss T70 telescope. Thanks to this collaboration, the whole project is on a fast track: it took only two years between taking the decision to build and first light. TRAPPIST will also be used for the study of southern comets. To this aim, the telescope is equipped with special large, high quality cometary filters, allowing astronomers to study regularly and in detail the ejection of several types of molecules by comets during their journey around the Sun. "With dozens of comets observed each year, this will provide us with a unique dataset, bringing important information about their nature," says Jehin. TRAPPIST is a lightweight 0.6-metre robotic telescope, fully automated and moving precisely across the sky at a high speed. The observing programme is prepared in advance and the telescope can perform a full night of observations unattended. A meteorological station monitors the weather continuously and decides to close the dome if necessary. Notes [1] A planetary transit occurs when a celestial body passes in front of its host star and blocks some of the star's light. This type of eclipse causes changes in the apparent brightness of the star and enables the planet's diameter to be measured. Combined with radial velocity measurements, it is also possible to deduce the mass and, hence, the density of the planet. More information TRAPPIST (TRAnsiting Planets and PlanetesImals Small Telescope) is a project led by the Department of Astrophysics, Geophysics and Oceanography (AGO) of the University of Liège (Belgium), in close collaboration with the Observatory of Geneva (Switzerland). TRAPPIST is mostly funded by the Belgian Fund for Scientific Research (FNRS) with the participation of the Swiss National Science Foundation (SNF). The team is composed of Emmanuël Jehin, Michaël Gillon, Pierre Magain, Virginie Chantry, Jean Manfroid, and Damien Hutsemékers (University of Li

      4. New National Telescope at La Silla - TRAPPIST to Scout the Sky and Uncover Exoplanets and Comets

        NASA Astrophysics Data System (ADS)

        2010-06-01

        Geneva Observatory, Switzerland. The telescope is installed in the building that housed the old Swiss T70 telescope. Thanks to this collaboration, the whole project is on a fast track: it took only two years between taking the decision to build and first light. TRAPPIST will also be used for the study of southern comets. To this aim, the telescope is equipped with special large, high quality cometary filters, allowing astronomers to study regularly and in detail the ejection of several types of molecules by comets during their journey around the Sun. "With dozens of comets observed each year, this will provide us with a unique dataset, bringing important information about their nature," says Jehin. TRAPPIST is a lightweight 0.6-metre robotic telescope, fully automated and moving precisely across the sky at a high speed. The observing programme is prepared in advance and the telescope can perform a full night of observations unattended. A meteorological station monitors the weather continuously and decides to close the dome if necessary. Notes [1] A planetary transit occurs when a celestial body passes in front of its host star and blocks some of the star's light. This type of eclipse causes changes in the apparent brightness of the star and enables the planet's diameter to be measured. Combined with radial velocity measurements, it is also possible to deduce the mass and, hence, the density of the planet. More information TRAPPIST (TRAnsiting Planets and PlanetesImals Small Telescope) is a project led by the Department of Astrophysics, Geophysics and Oceanography (AGO) of the University of Liège (Belgium), in close collaboration with the Observatory of Geneva (Switzerland). TRAPPIST is mostly funded by the Belgian Fund for Scientific Research (FNRS) with the participation of the Swiss National Science Foundation (SNF). The team is composed of Emmanuël Jehin, Michaël Gillon, Pierre Magain, Virginie Chantry, Jean Manfroid, and Damien Hutsemékers (University of Li

      5. Chemical and carbon isotopic evolution of hydrocarbons during prograde metamorphism from 100°C to 550°C: Case study in the Liassic black shale formation of Central Swiss Alps

        NASA Astrophysics Data System (ADS)

        Schwab, Valérie; Spangenberg, Jorge. E.; Grimalt, Joan O.

        2005-04-01

        Hydrocarbon distributions and stable isotope ratios of carbonates (δ 13C car, δ 18O car), kerogen (δ 13C ker), extractable organic matter (δ 13C EOM) and individual hydrocarbons of Liassic black shale samples from a prograde metamorphic sequence in the Swiss Alps were used to identify the major organic reactions with increasing metamorphic grade. The studied samples range from the diagenetic zone (<100°C) to amphibolite facies (˜550°C). The samples within the diagenetic zones (<100 and 150°C) are characterized by the dominance of C <20n-alkanes, suggesting an origin related with marine and/or bacterial inputs. The metamorphic samples (200 to 550°C) have distributions significantly dominated by C 12 and C 13n-alkanes, C 14, C 16 and C 18n-alkylcyclopentanes and to a lesser extend C 15, C 17 and C 21n-alkylcyclohexanes. The progressive 13C-enrichment (up to 3.9‰) with metamorphism of the C >17n-alkanes suggests the occurrence of cracking reactions of high molecular weight compounds. The isotopically heavier (up to 5.6 ‰) C <17n-alkanes in metamorphic samples are likely originated by thermal degradation of long-chain homologous with preferential release of isotopically light C 1 and C 2 radicals. The dominance of specific even C-number n-alkylcyclopentanes suggests an origin related to direct cyclization mechanism (without decarboxylation step) of algal or bacterial fatty acids occurring in reducing aqueous metamorphic fluid conditions. The regular increase of the concentrations of n-alkylcycloalkanes vs. C >13n-alkanes with metamorphism suggests progressive thermal release of kerogen-linked fatty acid precursors and degradation of n-alkanes. Changes of the steroid and terpenoid distributions are clearly related to increasing metamorphic temperatures. The absence of 18α(H)-22,29,30-trisnorneohopane (Ts), the occurrence of 17β(H)-trisnorhopane, 17β(H), 21α(H)-hopanes in the C 29 to C 31 range and 5α(H),14α(H),17α(H)-20R C 27, C 29 steranes in the

      6. PREFACE: 13th International Conference on Electrorheological Fluids and Magnetorheological Suspensions (ERMR2012)

        NASA Astrophysics Data System (ADS)

        Unal, Halil Ibrahim

        2013-02-01

        F Gonzalez-Caballero in 2014. It is expected that during the next conference, the interaction between polymer chemists synthesizing the new ER/MR materials, experimentalists from the rheological side characterizing their rheological properties, theoretical physicists describing the electric field and magnetic field dependent phenomena in ER/MR fluids rheology, and mechanical engineers conducting vibration damping tests will give rise to a deeper understanding of the ER/MR phenomena and will result in new findings in this field. The conference was sponsored by Gazi University, Anton-Paar GmbH, Kurimoto Ltd., Anamed Analitik Grup, TA Instruments, LORD Corporation, Turkish Powder Metallurgy Association (TTMD), LiKrom Ltd, Atomika Ltd., Turkish Patent Institute (TPI), Berkecan Ltd., Kurukahveci Mehmed Efendi Mahdumlari and Turkish Science-Research Foundation (TUBAV). The organizing committee truly appreciates the support from these organizations. Special appreciation is also due to my students O Erol and H C Gullu. I would also like to thank members of the Local Organizing Committee and International Advisory Board. Guest Editor H Ibrahim Unal Gazi University Science Faculty Chemistry Department 06500 Ankara/Turkey E-mail: hiunal@gazi.edu.tr

      7. [IL28B CC genotype: a protective factor and predictor of the response to interferon treatment in chronic hepatitis C virus infection].

        PubMed

        Pár, Alajos; Pár, Gabriella; Tornai, István; Szalay, Ferenc; Várszegi, Dalma; Fráter, Edit; Papp, Mária; Lengyel, Gabriella; Fehér, János; Varga, Márta; Gervain, Judit; Schuller, János; Nemes, Zsuzsanna; Péterfi, Zoltán; Tusnádi, Anna; Hunyady, Béla; Haragh, Attila; Szinku, Zsolt; Pálinkás, László; Berki, Tímea; Vincze, Aron; Kisfali, Péter; Melegh, Béla

        2013-08-11

        Bevezetés: Krónikus hepatitis C-vírus-fertőzésben a citokineket kódoló génvariánsok szerepének kutatása az érdeklődés előterébe került. Célkitűzés: A szerzők krónikus hepatitis C-vírus-fertőzöttekben vizsgálták az IL28B-polimorfizmusok előfordulását és az egyes variánsok hatását az interferonalapú antivirális kezelés kimenetelére. Meghatározták az összefüggést az IL28B genotípusok és a betegek perifériás vérében az aktivált monocyták és lymphocyták Th1/Th2 citokin termelése között. Módszer: A genetikai tanulmányba 748 krónikus hepatitis C-vírus-fertőzött egyént vontak be. Közülük 420 beteget kezeltek pegilált interferon alfa 2a/2b injekcióval és per os ribavirinnel 24–72 héten át. A kezelés utáni követési időszak tartama 24 hét volt. A peginterferonnal és ribavirinnel kezelt betegek közül 195 (46,4%) ért el tartós virológiai választ, vagyis 24 héttel a kezelés befejezése után hepatitis C-vírus-RNS-negativitást. Kontrollként 105 egészséges egyén szolgált, normális májpróbákkal és negatív hepatitis B- és C-vírus, valamint humán immundeficientiavírus-szerológiával. Genotipizáltak még 475 egészséges roma egyént (230 férfi, 245 nő, átlagéletkor 47±8 év). Az IL28B rs12979860 polimorfizmust Custom Taqman SNP Genotyping Assays (Applied Biosystems, Life Technologies, Foster, CA, USA) segítségével határozták meg. A Th1/Th2 citokinszint-vizsgálatokhoz 40 hepatitis C-vírus-fertőzött beteg TLR-4 ligand lipopoliszacharidával aktivált perifériás vér monocytáinak, valamint PMA+Ionomycin stimulált lymphocytáinak tumornekrózis-faktor-α-, interleukin-2-, interferon-γ-, interleukin-2- és interleukin-4-termelését mérték a sejtek felülúszójában FACS-CBA, Becton–Dickinson-teszttel. Eredmények: Az IL28B rs12979860 CC genotípus hepatitis C-vírus-fertőzött betegekben kisebb gyakorisággal fordult elő, mint a kontrollban (26,1% vs. 51

      8. INTRODUCTION: Nonequilibrium Processes in Plasmas

        NASA Astrophysics Data System (ADS)

        Petrović, Zoran; Marić, Dragana; Malović, Gordana

        2009-07-01

        have the presentation of monitoring of the deposition of airborne particles by the group from Belgrade led by Mirjana Tasić, and a study of such particles by elemental analysis by van Grieken and his colleagues from Belgium. We hope that the continuation of our workshops and the publication of our books will contribute to finding a common thread that connects different topics, even different fields, that share some aspects of the phenomena associated with non-equilibrium. As Anton Chekhov once stated 'Only entropy comes easy' so any work aimed at bringing order into the field is difficult. Organization of the workshop and publication of the book are of course not as hard as the pursuit of knowledge itself but we hope that it is, to some degree, a minor contribution to the everlasting human struggle against the entropy. And while we, of course, agree with scientists that are much better than we are that thermodynamics will never be overthrown, it is only human to try to cheat it. Doing the related science is allowing us to achieve exactly that and it is a source of numerous practical applications. The editors are grateful to all the members of the Gaseous Electronics Laboratory for organization of the workshop, in particular the members of the organizing committee and the staff of the Academy of Science and Institute of Physics. Finally and above all we acknowledge great efforts of all the participants who have invested a lot of funds, their time and effort to join us, sometimes travelling from distant continents. This book exists, however, mainly thanks to the efforts of all the authors who have invested their time and experience to write the papers. We also acknowledge the contribution by Professor Rastko Ćirić whose rendering of Maxwell's demon remains as symbol of our meeting and our publications. Perhaps the most chaotic aspect of human society, as our current experience teaches us, is the flow of funds and several agencies helped us get the needed funds to

      9. Spitzer Space Telescope Leads NASA's Great Observatories to Uncover Black Holes and Other Hidden Objects in the Distant Universe

        NASA Astrophysics Data System (ADS)

        2004-06-01

        galaxies. The X-rays are produced by interstellar gas that is attracted by the gravity of the black holes and is heated to very high temperatures just before it falls in. Hubble's Advanced Camera for surveys revealed optical galaxies around almost all the X-ray black holes. However, there remained seven mysterious X-ray sources for which there was no optical galaxy in the Hubble images. Astronomer Anton Koekemoer of the Space Telescope Science Institute in Baltimore, Md., who discovered these sources, presented three intriguing possibilities for their origin. "The galaxies around these black holes may be completely hidden by thick clouds of dust absorbing all their light, or may contain very old, red stars," suggests Koekemoer, "or some of them could be the most distant black holes ever observed -- perhaps as far as 13 billion light-years." In this case all their optical light would be shifted to very long infrared wavelengths by the expansion of the universe. The Spitzer images were anxiously awaited to resolve the puzzle of these optically invisible X-ray black holes. Because Spitzer observes in infrared light, at wavelengths up to 100 times longer than those probed by Hubble, Spitzer might be able to see the otherwise invisible objects. Indeed, the very first Spitzer images of these objects, obtained in early 2004, immediately revealed the telltale infrared glow from the host galaxies around all the missing X-ray black holes. "The Spitzer images are fantastic," says Koekemoer, who led the effort to compare and identify the missing X-ray black holes in the Spitzer images. "For the first time ever, we have identified 100 percent of the galaxies around X-ray black holes." Three of Koekemoer's galaxies are extremely red, even redder than the other galaxies found so far in this field. The Spitzer data, together with new images at shorter (but still infrared) wavelengths from the Very Large Telescope at the European Southern Observatory, indicate that the galaxies around

      10. Photonic, Electronic and Atomic Collisions

        NASA Astrophysics Data System (ADS)

        Fainstein, Pablo D.; Lima, Marco Aurelio P.; Miraglia, Jorge E.; Montenegro, Eduardo C.; Rivarola, Roberto D.

        2006-11-01

        -coincidence technique / T. Kaneyasu, T. Azuma and K. Okuno. Recent developments in proton-transfer-reaction mass spectrometry / A. Wisthaler ... [et al.]. Interferences in electron emission from H[symbol] induced by fast ions / N. Stolterfoht. Atomic realization of the young single electron interference process in individual autoionization collisions / R. O. Barrachina and M. Šitnik. Multiple ionization processes related to irradiation of biological tissue / M. E. Galassi ... [et al.]. Atom-diatom collisions at cold and ultra-cold temperatures / F. D. Colavecchia, G. A. Parker and R. T. Pack. Interactions of ions with hydrogen atoms / A. Luca, G. Borodi and D. Gerlich. Analysis of all structures in the elastic and charge transfer cross sections for proton-hydrogen collisions in the range of 10[symbol]-10øeV / P. S. Krstić ... [et al.]. Ab-initio ion-atom collision calculations for many-electron systems / J. Anton and B. Fricke. Fully differential studies on single ionization of helium by slow proton impact / A. Hasan ... [et al.]. Dipole polarization effects on highly-charged-ion-atom electron capture / C. C. Havener ... [et al.]. Proton-, antiproton-, and photon-he collisions in the context of ultra fast processes / T. Morishita ... [et al.]. Impact parameter dependent charge exchange studies with channeled heavy ions / D. Dauvergne ... [et al.]. Crystal assisted atomic physics experiments using heavy ions / K. Komaki -- Collisions involving clusters and surfaces. Structure and dynamics of Van der Waal complexes: from triatomic to medium size clusters / G. Delgado Barrio ... [et al.]. Evaporation, fission and multifragmentation processes of multicharged C[symbol] ions versus excitation energies / S. Martin ... [et al.]. Fragmentation of collisionally excited fullerenes / M. Alcami, S. Diaz-Tendero and F. Martín. Lifetimes of C[symbol] and C[symbol] dianions in a storage ring / S. Tomita ... [et al.]. Clusters and clusters of clusters in collisions / B. Manil ... [et al

      11. Observing a Burst with Sunglasses

        NASA Astrophysics Data System (ADS)

        2003-11-01

        factor by which the lines in the spectrum of an object are shifted towards longer wavelengths. Since the redshift of a cosmological object increases with distance, the observed redshift of a remote galaxy also provides an estimate of its distance. [2]: Members of the team include Jochen Greiner, Arne Rau (Max-Planck-Institut für extraterrestrische Physik, Germany), Sylvio Klose, Bringfried Stecklum (Thüringer Landessternwarte Tautenburg, Germany), Klaus Reinsch (Universitätssternwarte Göttingen, Germany), Hans Martin Schmid (Institut für Astronomie Zürich, Switzerland ), Re'em Sari (California Institute of Technology, USA), Dieter H. Hartmann (Clemson University, USA), Chryssa Kouveliotou (NSSTC, Huntsville, Alabama, USA), Eliana Palazzi (Istituto di Astrofisica Spaziale e Fisica Cosmica, Bologna, Italy), Christian Straubmeier (Physikalisches Institut Köln, Germany), Sergej Zharikov, Gaghik Tovmassian (Instituto de Astronomia Ensenada, Mexico), Otto Bärnbantner, Christop Ries (Wendelstein-Observatorium München, Germany), Emmanuel Jehin, Andreas Kaufer (European Southern Observatory, Chile), Arne Henden (USNO Flagstaff, USA), Anlaug A. Kaas (NOT, La Palma, Spain), Tommy Grav (University of Oslo, N), Jens Hjorth, Holger Pedersen (Astronomical Observatory Copenhagen, Denmark), Ralph A.M.J. Wijers (Astronomical Institute Anton Pannekoek, Amsterdam, The Netherlands), Hye-Sook Park (Lawrence Livermore Nat. Laboratory, USA), Grant Williams (MMT Observatory, Tucson, USA), Olaf Reimer (Theoretische Weltraum- und Astrophysik Universität Bochum, Germany) [3]: When electrons - which are electrically charged - move through a magnetic field, they spiral around an axis defined by the local magnetic field. Electrons of high energy spiral very rapidly, at speeds near the speed of light. Under such conditions, the electrons emit highly polarised electromagnetic radiation. The intensity of this radiation is related to the strength of the magnetic field and the number and energy

      12. A Supermassive Black Hole in a Nearby Galaxy

        NASA Astrophysics Data System (ADS)

        2001-03-01

        black hole. It is the first time infrared spectroscopy has been used to weigh a black hole. Many other galaxies have dust-enshrouded nuclei, and the excellent capabilities of ISAAC now hold a great potential to discover and weigh many more black holes. More Information The research described in this Press Release is reported in a research article ("Peering through the dust: Evidence for a supermassive Black Hole at the Nucleus of Centaurus A from VLT IR spectroscopy"), that will appear in the international research journal the Astrophysical Journal on March 10, 2001. The full article is also available on the web as astro-ph/0011059. Note [1]: The team is composed by Ethan Schreier (Principal Investigator; Space Telescope Science Institute - STScI, Baltimore, USA), Alessandro Marconi (Arcetri Observatory, Italy), Alessandro Capetti (Turin Observatory, Italy), David Axon (University of Hertfordshire, United Kingdom), Anton Koekemoer (STScI, USA) and Duccio Macchetto (ESA/STScI, USA). Technical information about the photos PR Photo 08a/01 is reproduced from three exposures, obtained during the night of January 31 - February 1, 2000. It is a composite of three exposures in B (300 sec exposure, image quality 0.60 arcsec; here rendered in blue colour), V (240 sec, 0.60 arcsec; green) and R (240 sec, 0.55 arcsec; red). The field covered corresponds to about 80 x 80 arcsec 2 (395 x 395 pix 2 , 1 pix = 0.2 arcsec). North is up and East is left. PR Photo 08b+c/01 : The original ISAAC spectra were exposed for 35 min each with an average seeing of 0.5 arcsec. Three spectrograph slits were used, but only one of these is shown here. It was centered on the nucleus of Centaurus A and oriented at 33°, measured counter-clockwise from the North direction. The spectral pixel size is 0.6 Angstrom x 0.15 arcsec (i.e., 14 km/sec x 8.3 light-year). The large and small figures cover 2300 km/s x 1665 light-years and 1150 km/s x 330 light-years, respectively.

      13. The Dark Side of Nature: the Crime was Almost Perfect

        NASA Astrophysics Data System (ADS)

        2006-12-01

        Klose (Thüringer Landessternwarte Tautenburg, Germany), Jean-Baptiste Marquette (Institut d'Astrophysique de Paris, France), Enrico Ramirez-Ruiz (Institute for Advanced Study, Princeton and Department of Astronomy and Astrophysics, University of California, Santa Cruz, USA), Paul M. Vreeswijk (ESO and Departamento de Astronomia, Universidad de Chile, Santiago, Chile), and Ralph A. M. Wijers (Astronomical Institute 'Anton Pannekoek', University of Amsterdam, The Netherlands).

      14. Chandra and the VLT Jointly Investigate the Cosmic X-Ray Background

        NASA Astrophysics Data System (ADS)

        2001-03-01

        Hasinger , Gyula Szokoly (Astrophysical Institute Potsdam [AIP], Germany), Colin Norman , Roberto Gilli , Lisa Kewley , Wei Zheng , Andrew Zirm , JungXian Wang (Johns Hopkins University [JHU], Baltimore, USA), Ken Kellerman (National Radio Astronomy Observatory [NRAO], Charlottesville, USA), Ethan Schreier , Anton Koekemoer and Norman Grogin (Space Telescope Science Institute (STScI), Baltimore, USA). [2] In astronomy, the redshift denotes the fraction by which the lines in the spectrum of an object are shifted towards longer wavelengths. The observed redshift of a distant galaxy or quasar gives a direct estimate of the apparent recession velocity as caused by the universal expansion. Since the expansion rate increases with the distance, the velocity is itself a function (the Hubble relation) of the distance to the object. Redshifts of 1 and 3.7 correspond to when the Universe was about 43% and 12% of its present age. The distances indicated in this Press Release depend on the cosmological model chosen and are based on an age of 19,000 million years. Technical information about the photos PR Photo 09a/01 shows B-, R- and I-band images of a 20 x 20 arcsec 2 area within the CDFS, centred on the Type II Quasar CXOCDFS J033229.9 -275106 . They were obtained with the MPG/ESO 2.2-m telescope and the Wide-Field Imager (WFI) at La Silla (B-band; 8 hrs exposure time) and the 8.2-m VLT ANTU telescope with the FORS1 multi-mode instrument at Paranal (R- and I-bands; each 2 hrs exposure). The measured magnitudes are R=23.5 and I=22.7. The overlaid contours show the associated Chandra X-ray source (smoothed with a sigma = 1 arcsec gaussian profile). North is up and East is left. The spectrum shown in PR Photo 09b/01 was obtained on November 25, 2000, with VLT ANTU and FORS1 in the multislit mode (150-I grism, 1.2 arcsec slit). The exposure time was 3 hours.

      15. Nearest Cosmic Mirage

        NASA Astrophysics Data System (ADS)

        2003-07-01

        will use new observations which are currently being obtained with the VLT at Paranal, with the VLA radio interferometer in New Mexico and with the Hubble Space Telescope. More information The research described in this press release is presented in a Letter to the Editor, soon to appear in the European professional journal Astronomy & Astrophysics ("A quadruply imaged quasar with an optical Einstein ring candidate : 1RXS J113155.4-123155", by Dominique Sluse et al.). More information on gravitational lensing and on this research group can also be found at the URL : http://www.astro.ulg.ac.be/GRech/AEOS/. Notes [1]: The team consists of Dominique Sluse, Damien Hutsemékers, and Thodori Nakos (ESO and Institut d'Astrophysique et de Géophysique de l'Université de Liège - IAGL), Jean-François Claeskens, Frédéric Courbin, Christophe Jean, and Jean Surdej (IAGL), Malvina Billeres (ESO), and Sergiy Khmil (Astronomical Observatory of Shevchentko University). [2]: Quasars are particularly active galaxies, the centres of which emit prodigious amounts of energy and energetic particles. It is believed that they harbour a massive black hole at their centre and that the energy is produced when surrounding matter falls into this black hole. This type of object was first discovered in 1963 by the Dutch-American astronomer Maarten Schmidt at the Palomar Observatory (California, USA) and the name refers to their "star-like" appearance on the images obtained at that time. [3]: In astronomy, the "redshift" denotes the fraction by which the lines in the spectrum of an object are shifted towards longer wavelengths. Since the redshift of a cosmological object increases with distance, the observed redshift of a remote galaxy also provides an estimate of its distance.

      16. The Most Remote Gamma-Ray Burst

        NASA Astrophysics Data System (ADS)

        2000-10-01

        , Denmark), Johan Fynbo, Palle Møller (European Southern Observatory), Richard Marc Kippen (University of Alabama in Huntsville and NASA/Marshall Space Flight Center, USA), Bjarne Thomsen (University of Århus, Denmark), Marianne Vestergaard (Ohio State University, USA), Nicola Masetti, Eliana Palazzi (Instituto Tecnologie e Studio Radiazoni Extraterresti, Bologna, Italy) Kevin Hurley (University of California, Berkeley, USA), Thomas Cline (NASA Goddard Space Flight Center, Greenbelt, USA), Lex Kaper (Sterrenkundig Instituut ``Anton Pannekoek", the Netherlands) and Andreas O. Jaunsen (formerly University of Oslo, Norway; now ESO-Paranal). [2]: Detailed reports about the early observations of this gamma-ray burst are available at the dedicated webpage within the GRB Coordinates Network website. [3]: The photometric redshift method makes it possible to judge the distance to a remote celestial object (a galaxy, a quasar, a gamma-ray burst afterglow) from its measured colours. It is based on the proportionality between the distance and the velocity along the line of sight (Hubble's law) that reflects the expansion of the Universe. The larger the distance of an object is, the larger is its velocity and, due to the Doppler effect, the spectral shift of its emission towards longer (redder) wavelengths. Thus, the measured colour provides a rough indication of the distance. Examples of this method are shown in ESO PR 20/98 (Photos 48a/00 and 48e/00). [4]: In fact, the object was so faint that the positioning of the spectrograph slit had to be done in "blind" offset, i.e. without actually seeing the object on the slit during the observation. This very difficult observational feat was possible because of excellent preparations by the team of astronomers and the very good precision of the telescope and instrument. [5]: The " Lyman-alpha forest" refers to the crowding of absorption lines from intervening hydrogen clouds, shortward of the strong Lyman-alpha spectral line at rest