Sample records for ap600 design certification

  1. 10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Design Certification Rule for the AP600 Design C Appendix C to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Pt. 52, App. C Appendix C to Part 52—Design Certification Rule for the...

  2. 10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... design, in accordance with 10 CFR part 52, subpart B. The applicant for certification of the AP600 design... appendix. B. Generic technical specifications means the information, required by 10 CFR 50.36 and 50.36a... licensee must meet the requirement in Section III.B of this appendix to reference Tier 2 when referencing...

  3. 10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... design, in accordance with 10 CFR part 52, subpart B. The applicant for certification of the AP600 design....55(b) and 52.57(b). This appendix remains valid for an applicant or licensee who references this.... Exemptions from Tier 1 information are governed by the requirements in 10 CFR 52.63(b)(1) and 52.98(f). The...

  4. 10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., Manager, Passive Plant Engineering, Westinghouse Electric Company, P.O. Box 355, Pittsburgh, Pennsylvania... Web site, http://www.nrc.gov, and/or at the NRC Public Document Room, is insufficient; c. The...) Fuel criteria evaluation process. (4) Fire areas. (5) Human factors engineering. c. A licensee who...

  5. 10 CFR Appendix C to Part 52 - Design Certification Rule for the AP600 Design

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., Manager, Passive Plant Engineering, Westinghouse Electric Company, P.O. Box 355, Pittsburgh, Pennsylvania... Web site, http://www.nrc.gov, and/or at the NRC Public Document Room, is insufficient; c. The...) Fuel criteria evaluation process. (4) Fire areas. (5) Human factors engineering. c. A licensee who...

  6. Thermal-hydraulic modeling needs for passive reactors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kelly, J.M.

    1997-07-01

    The U.S. Nuclear Regulatory Commission has received an application for design certification from the Westinghouse Electric Corporation for an Advanced Light Water Reactor design known as the AP600. As part of the design certification process, the USNRC uses its thermal-hydraulic system analysis codes to independently audit the vendor calculations. The focus of this effort has been the small break LOCA transients that rely upon the passive safety features of the design to depressurize the primary system sufficiently so that gravity driven injection can provide a stable source for long term cooling. Of course, large break LOCAs have also been considered,more » but as the involved phenomena do not appear to be appreciably different from those of current plants, they were not discussed in this paper. Although the SBLOCA scenario does not appear to threaten core coolability - indeed, heatup is not even expected to occur - there have been concerns as to the performance of the passive safety systems. For example, the passive systems drive flows with small heads, consequently requiring more precision in the analysis compared to active systems methods for passive plants as compared to current plants with active systems. For the analysis of SBLOCAs and operating transients, the USNRC uses the RELAP5 thermal-hydraulic system analysis code. To assure the applicability of RELAP5 to the analysis of these transients for the AP600 design, a four year long program of code development and assessment has been undertaken.« less

  7. AP1000{sup R} licensing and deployment in the United States

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jordan, R. P.; Russ, P. A.; Filiak, P. P.

    2012-07-01

    In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two newmore » nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing actions directed towards deployment. AP1000 Design Certification and COL deployment, and management of the plant construction in accordance with the conditions within these approvals, remain as significant site and corporate responsibilities. These licensing-construction integrated activities must now focus on identifying and resolving 'as-built' departures from the standardized design as assessed against the certified AP1000 technical and licensing basis. Within this paper, significant aspects of the AP1000 U.S. licensing will be discussed, including identifying systems and processes used in ensuring compliance while deploying the standardized design. Critical licensing steps, licensing deployment actions as plant construction progresses and defining the road forward to a successful completion of licensing actions will be addressed. (authors)« less

  8. 77 FR 56241 - Notice of Withdrawal of Final Design Approval; Westinghouse Electric Company; Advanced Passive 1000

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... NUCLEAR REGULATORY COMMISSION [NRC-2010-0131] Notice of Withdrawal of Final Design Approval... final design approval (FDA) for the Advanced Passive 1000 (AP1000) design upon the completion of rulemaking for the amendment to the AP1000 design and the issuance of the amended AP1000 design certification...

  9. Information on the Advanced Plant Experiment (APEX) Test Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, Curtis Lee

    The purpose of this report provides information related to the design of the Oregon State University Advanced Plant Experiment (APEX) test facility. Information provided in this report have been pulled from the following information sources: Reference 1: R. Nourgaliev and et.al, "Summary Report on NGSAC (Next-Generation Safety Analysis Code) Development and Testing," Idaho National Laboratory, 2011. Note that this is report has not been released as an external report. Reference 2: O. Stevens, Characterization of the Advanced Plant Experiment (APEX) Passive Residual Heat Removal System Heat Exchanger, Master Thesis, June 1996. Reference 3: J. Reyes, Jr., Q. Wu, and J.more » King, Jr., Scaling Assessment for the Design of the OSU APEX-1000 Test Facility, OSU-APEX-03001 (Rev. 0), May 2003. Reference 4: J. Reyes et al, Final Report of the NRC AP600 Research Conducted at Oregon State University, NUREG/CR-6641, July 1999. Reference 5: K. Welter et al, APEX-1000 Confirmatory Testing to Support AP1000 Design Certification (non-proprietary), NUREG-1826, August 2005.« less

  10. 76 FR 82079 - AP1000 Design Certification Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... reference Revision 15 of the design control document (DCD) (ADAMS Accession No. ML053460400), which... to DAC in the areas of piping design (Chapter 3), instrumentation and control (I&C) systems (Chapter... Systems Manual, as described in the AP1000 Design Control Document, Revision 17, meets the criteria of...

  11. In-vessel coolability and retention of a core melt. Volume 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Theofanous, T.G.; Liu, C.; Additon, S.

    1996-10-01

    The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is physically unreasonable. Use of this conclusion for any specific application is subject to verifying the requiredmore » reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings. The AP600 is particularly favorable to in-vessel retention. Some ideas to enhance the assessment basis as well as performance in this respect, for applications to larger and/or higher power density reactors are also provided.« less

  12. In-vessel coolability and retention of a core melt. Volume 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Theofanous, T.G.; Liu, C.; Additon, S.

    1996-10-01

    The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is physically unreasonable. Use of this conclusion for any specific application is subject to verifying the requiredmore » reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings. The AP600 is particularly favorable to in-vessel retention. Some ideas to enhance the assessment basis as well as performance in this respect, for applications to larger and/or higher power density reactors are also provided.« less

  13. SPES-2, an experimental program to support the AP600 development

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tarantini, M.; Medich, C.

    1995-09-01

    In support of the development of the AP600 reactor, ENEA, ENEL, ANSALDO and Westinghouse have signed a research agreement. In the framework of this agreement a complex Full Height Full Pressure (FHFP) integral system testing program has been planned on SPES-2 facility. The main purpose of this paper is to point out the status of the test program; describe the hot per-operational test performed and the complete test matrix, giving all the necessary references on the work already published. Two identical Small Break LOCA transients, performed with Pressurizer to Core Make-up Tank (PRZ-CMT) balance line (Test S00203) and without PRZ-CMTmore » balance line (Test S00303) are then compared, to show how the SPES-2 facility can contribute in confirming the new AP600 reactor design choices and can give useful indications to designers. Although the detailed analysis of test data has not been completed, some consideration on the analytical tools utilized and on the SPES-2 capability to simulate the reference plant is then drawn.« less

  14. Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis

    PubMed Central

    Párniczky, Andrea; Kui, Balázs; Szentesi, Andrea; Balázs, Anita; Szűcs, Ákos; Mosztbacher, Dóra; Czimmer, József; Sarlós, Patrícia; Bajor, Judit; Gódi, Szilárd; Vincze, Áron; Illés, Anita; Szabó, Imre; Pár, Gabriella; Takács, Tamás; Czakó, László; Szepes, Zoltán; Rakonczay, Zoltán; Izbéki, Ferenc; Gervain, Judit; Halász, Adrienn; Novák, János; Crai, Stefan; Hritz, István; Góg, Csaba; Sümegi, János; Golovics, Petra; Varga, Márta; Bod, Barnabás; Hamvas, József; Varga-Müller, Mónika; Papp, Zsuzsanna; Sahin-Tóth, Miklós; Hegyi, Péter

    2016-01-01

    Objective The aim of this study was to analyse the clinical characteristics of acute pancreatitis (AP) in a prospectively collected, large, multicentre cohort and to validate the major recommendations in the IAP/APA evidence-based guidelines for the management of AP. Design Eighty-six different clinical parameters were collected using an electronic clinical research form designed by the Hungarian Pancreatic Study Group. Patients 600 adult patients diagnosed with AP were prospectively enrolled from 17 Hungarian centres over a two-year period from 1 January 2013. Main Results With respect to aetiology, biliary and alcoholic pancreatitis represented the two most common forms of AP. The prevalence of biliary AP was higher in women, whereas alcoholic AP was more common in men. Hyperlipidaemia was a risk factor for severity, lack of serum enzyme elevation posed a risk for severe AP, and lack of abdominal pain at admission demonstrated a risk for mortality. Abdominal tenderness developed in all the patients with severe AP, while lack of abdominal tenderness was a favourable sign for mortality. Importantly, lung injury at admission was associated with mortality. With regard to laboratory parameters, white blood cell count and CRP were the two most sensitive indicators for severe AP. The most common local complication was peripancreatic fluid, whereas the most common distant organ failure in severe AP was lung injury. Deviation from the recommendations in the IAP/APA evidence-based guidelines on fluid replacement, enteral nutrition and timing of interventions increased severity and mortality. Conclusions Analysis of a large, nationwide, prospective cohort of AP cases allowed for the identification of important determinants of severity and mortality. Evidence-based guidelines should be observed rigorously to improve outcomes in AP. PMID:27798670

  15. 76 FR 10269 - AP1000 Design Certification Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... design control document proposals. For the final rule, the NRC will complete the review of the CIs and... control requirement includes the descriptions of the design features and functional capabilities... objective of the change controls is to determine whether the design of the facility, as changed or modified...

  16. 38 CFR 58.13 - VA Form 10-10SH-State Home Program Application for Veteran Care Medical Certification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false VA Form 10-10SH-State Home Program Application for Veteran Care Medical Certification. 58.13 Section 58.13 Pensions, Bonuses... Home Program Application for Veteran Care Medical Certification. ER29AP09.150 ER29AP09.151 ER29AP09.152...

  17. 10 CFR Appendix D to Part 52 - Design Certification Rule for the AP1000 Design

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... under 10 CFR 50.90. (1) Maximum fuel rod average burn-up. (2) Fuel principal design requirements. (3... Cases. (3) Design Summary of Critical Sections. (4) American Concrete Institute (ACI) 318, ACI 349... control system, except burn-up limit. (8) Motor-operated and power-operated valves. (9) Instrumentation...

  18. 10 CFR Appendix D to Part 52 - Design Certification Rule for the AP1000 Design

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... under 10 CFR 50.90. (1) Maximum fuel rod average burn-up. (2) Fuel principal design requirements. (3... Cases. (3) Design Summary of Critical Sections. (4) American Concrete Institute (ACI) 318, ACI 349... control system, except burn-up limit. (8) Motor-operated and power-operated valves. (9) Instrumentation...

  19. 10 CFR Appendix D to Part 52 - Design Certification Rule for the AP1000 Design

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... under 10 CFR 50.90. (1) Maximum fuel rod average burn-up. (2) Fuel principal design requirements. (3... Cases. (3) Design Summary of Critical Sections. (4) American Concrete Institute (ACI) 318, ACI 349... control system, except burn-up limit. (8) Motor-operated and power-operated valves. (9) Instrumentation...

  20. 10 CFR Appendix D to Part 52 - Design Certification Rule for the AP1000 Design

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... amendment under 10 CFR 50.90. (1) Maximum fuel rod average burn-up. (2) Fuel principal design requirements... Case-284. (3) Design Summary of Critical Sections. (4) American Concrete Institute (ACI) 318, ACI 349... control system, except burn-up limit. (8) Motor-operated and power-operated valves. (9) Instrumentation...

  1. 10 CFR Appendix D to Part 52 - Design Certification Rule for the AP1000 Design

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... amendment under 10 CFR 50.90. (1) Maximum fuel rod average burn-up. (2) Fuel principal design requirements... Case-284. (3) Design Summary of Critical Sections. (4) American Concrete Institute (ACI) 318, ACI 349... control system, except burn-up limit. (8) Motor-operated and power-operated valves. (9) Instrumentation...

  2. SPES-2, AP600 intergral system test S01007 2 inch CL to core make-up tank pressure balance line break

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bacchiani, M.; Medich, C.; Rigamonti, M.

    1995-09-01

    The SPES-2 is a full height, full pressure experimental test facility reproducing the Westinghouse AP600 reactor with a scaling factor of 1/395. The experimental plant, designed and operated by SIET in Piacenza, consists of a full simulation of the AP600 primary core cooling system including all the passive and active safety systems. In 1992, Westinghouse, in cooperation with ENEL (Ente Nazionale per l` Energia Elettrica), ENEA (Enter per le numove Technlogie, l` Energia e l` Ambient), Siet (Societa Informazioni Esperienze Termoidraulich) and ANSALDO developed an experimental program to test the integrated behaviour of the AP600 passive safety systems. The SPES-2more » test matrix, concluded in November 1994, has examined the AP600 passive safety system response for a range of small break LOCAs at different locations on the primary system and on the passive system lines; single steam generator tube ruptures with passive and active safety systems and a main steam line break transient to demonstrate the boration capability of passive safety systems for rapid cooldown. Each of the tests has provided detailed experimental results for verification of the capability of the analysis methods to predict the integrated passive safety system behaviour. Cold and hot shakedown tests have been performed on the facility to check the characteristics of the plant before starting the experimental campaign. The paper first presents a description of the SPES-2 test facility then the main results of S01007 test {open_quotes}2{close_quotes} Cold Leg (CL) to Core Make-up Tank (CMT) pressure balance line break{close_quotes} are reported and compared with predictions performed using RELAP5/mod3/80 obtained by ANSALDO through agreement with U.S.N.R.C. (U.S. Nuclear Regulatory Commission). The SPES-2 nodalization and all the calculations here presented were performed by ANSALDO and sponsored by ENEL as a part of pre-test predictions for SPES-2.« less

  3. The AP1000{sup R} China projects move forward to construction completion and equipment installation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harrop, G.

    2012-07-01

    The AP1000 design is the only Generation III+ technology to receive design certification from the U.S. Nuclear Regulatory Commission. This evolutionary design provides the highest safety and performance standards and has several distinct advantages over other designs, including improved operations and reduced construction schedule risks through the use of modern, modular, engineering principles that allow construction and fabrication tasks traditionally performed in sequence to be undertaken in parallel. Since the first granting of Design Certification in 2005 by the NRC, the AP1000 design has been modified to meet emergent NRC requirements such as those requiring the design to withstand themore » impact of an aircraft crash. Both domestic and foreign utilities have turned to the Westinghouse AP1000 plant design to meet their near - and long-term sustainable energy needs. The first ever deployment of this advanced U.S. nuclear power technology began in China in 2007 with the award of a contract to build four AP1000 units, constructed in pairs at the coastal sites of Sanmen (Zhejiang Province) and Haiyang (Shandong Province). Currently, all four units are at an advanced stage of construction. The commercial operation date for Sanmen Unit 1 is November 2013 followed by Haiyang Unit 1 being operational in May 2014. Construction and equipment manufacture is at an advanced stage. Sanmen Unit 1 equipment that has been delivered includes the reactor vessel, the reactor vessel closure head, the passive residual heat removal heat exchanger, the integrated head package, the polar crane, and the refueling machine. The steam generators are also completed. The RV was installed within the containment vessel building in September 2011. The installation of this major equipment will allow the setting of the containment vessel top head. Haiyang Unit 1 is also achieving significant progress. Significant benefits continue to be realized as a result of lessons learned and experience gained from the first-of-a-kind activities for Sanmen Unit 1 and AP1000 equipment design and manufacturing. For example, the nuclear island basemat at Haiyang Units 1 and 2 and Sanmen Unit 2 was laid in less time than that of Sanmen Unit 1, the ultra-large steam generator and RV forging lead times were reduced for the follow on units, and the fabrication of the auxiliary building module for Haiyang Unit 1 took less time than for the Sanmen first unit. These benefits are also being realized by the United States AP1000 project construction and fabrication modules, and equipment. Some difficulties arise from building this first-of-a-kind (advanced passive) type of plant; however, these difficulties are being overcome and the overall schedule remains achievable. (authors)« less

  4. 76 FR 12274 - Special Conditions: Bell Helicopter Textron Canada Limited Model 206B and 206L Series Helicopters...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ..., Type Certificate Number H2SW. This AP/SAS performs non- critical control functions, since this model... helicopters. These model helicopters will have novel or unusual design features when modified by installing..., Aviation Safety Engineer, FAA, Rotorcraft Directorate, Regulations and Policy Group (ASW-111), 2601 Meacham...

  5. ALARA radiation considerations for the AP600 reactor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lau, F.L.

    1995-03-01

    The radiation design of the AP600 reactor plant is based on an average annual occupational radiation exposure (ORE) of 100 man-rem. As a design goal we have established a lower value of 70 man-rem per year. And, with our current design process, we expect to achieve annual exposures which are well below this goal. To accomplish our goal we have established a process that provides criteria, guidelines and customer involvement to achieve the desired result. The criteria and guidelines provide the shield designer, as well as the systems and plant layout designers with information that will lead to an integratedmore » plant design that minimizes personnel exposure and yet is not burdened with complicated shielding or unnecessary component access limitations. Customer involvement is provided in the form of utility input, design reviews and information exchange. Cooperative programs with utilities in the development of specific systems or processes also provides for an ALARA design. The results are features which include ALARA radiation considerations as an integral part of the plant design and a lower plant ORE. It is anticipated that a further reduction in plant personnel exposures will result through good radiological practices by the plant operators. The information in place to support and direct the plant designers includes the Utility Requirements Document (URD), Federal Regulations, ALARA guidelines, radiation design information and radiation and shielding design criteria. This information, along with the utility input, design reviews and information feedback, will contribute to the reduction of plant radiation exposure levels such that they will be less than the stated goals.« less

  6. A model for studying the energetics of sustained high frequency firing

    PubMed Central

    Morris, Catherine E.

    2018-01-01

    Regulating membrane potential and synaptic function contributes significantly to the energetic costs of brain signaling, but the relative costs of action potentials (APs) and synaptic transmission during high-frequency firing are unknown. The continuous high-frequency (200-600Hz) electric organ discharge (EOD) of Eigenmannia, a weakly electric fish, underlies its electrosensing and communication. EODs reflect APs fired by the muscle-derived electrocytes of the electric organ (EO). Cholinergic synapses at the excitable posterior membranes of the elongated electrocytes control AP frequency. Based on whole-fish O2 consumption, ATP demand per EOD-linked AP increases exponentially with AP frequency. Continual EOD-AP generation implies first, that ion homeostatic processes reliably counteract any dissipation of posterior membrane ENa and EK and second that high frequency synaptic activation is reliably supported. Both of these processes require energy. To facilitate an exploration of the expected energy demands of each, we modify a previous excitability model and include synaptic currents able to drive APs at frequencies as high as 600 Hz. Synaptic stimuli are modeled as pulsatile cation conductance changes, with or without a small (sustained) background conductance. Over the full species range of EOD frequencies (200–600 Hz) we calculate frequency-dependent “Na+-entry budgets” for an electrocyte AP as a surrogate for required 3Na+/2K+-ATPase activity. We find that the cost per AP of maintaining constant-amplitude APs increases nonlinearly with frequency, whereas the cost per AP for synaptic input current is essentially constant. This predicts that Na+ channel density should correlate positively with EOD frequency, whereas AChR density should be the same across fish. Importantly, calculated costs (inferred from Na+-entry through Nav and ACh channels) for electrocyte APs as frequencies rise are much less than expected from published whole-fish EOD-linked O2 consumption. For APs at increasingly high frequencies, we suggest that EOD-related costs external to electrocytes (including packaging of synaptic transmitter) substantially exceed the direct cost of electrocyte ion homeostasis. PMID:29708986

  7. 75 FR 70090 - Special Conditions: Bombardier Inc. Model CL-600-2E25 Airplane, Operation Without Normal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ..., Aircraft Certification Service, 1601 Lind Avenue, SW., Renton, Washington, 98057-3356; telephone (425) 227... would significantly delay issuance of the design approval and thus delivery of the affected aircraft. In... Minimum Operating Speed Factors. 2. Section 25.811(d)(2), Main Door Exit Marking Sign. 3. Section 25.813(c...

  8. Non-condensable gas effects in ROSA/AP600 small-break LOCA experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nakamura, Hideo; Kukita, Yutaka; Shaw, R.A.

    1996-06-01

    Integral experiments simulating the postulated accidents in the Westinghouse AP600 reactor have been conducted using the ROSA-V Large Scale Test Facility (LSTF). These experiments allowed the N{sub 2} gas for the pressurization of accumulator tanks to enter the primary system after the depletion of the tank water inventory. The gas migrated into the Passive Residual Heat Removal (PRHR) system heat exchanger tubes and into the Core Makeup Tanks (CMTs), and influenced the performance of these components which are unique to the AP600 reactor. Specifically, the PRHR was disabled soon after the N{sub 2} gas discharge in most of the experiments,more » although the core decay power was removed well by the steam discharge through the Automatic Depressurization System (ADS) after the PRHR was disabled. The N{sub 2} gas ingress into the CMTs occurred in the experiments with relatively large breaks ({ge} 2 inch in equivalent diameter), and contributed to a smooth draindown of the CMT inventory into the primary system.« less

  9. 40 CFR 600.010-86 - Vehicle test requirements and minimum data requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... base level, and (iii) For additional model types established under § 600.207(a)(2), data from each... data requirements. 600.010-86 Section 600.010-86 Protection of Environment ENVIRONMENTAL PROTECTION... Provisions § 600.010-86 Vehicle test requirements and minimum data requirements. (a) For each certification...

  10. AP reclamation and reuse in RSRM propellant

    NASA Technical Reports Server (NTRS)

    Miks, Kathryn F.; Harris, Stacey A.

    1995-01-01

    A solid propellant ingredient reclamation pilot plant has been evaluated at the Strategic Operations of Thiokol Corporation, located in Brigham City, Utah. The plant produces AP wet cake (95 percent AP, 5 percent water) for recycling at AP vendors. AP has been obtained from two standard propellant binder systems (PBAN and HTPB). Analytical work conducted at Thiokol indicates that the vendor-recrystallized AP meets Space Shuttle propellant specification requirements. Thiokol has processed 1-, 5-, and 600-gallon propellant mixes with the recrystallized AP. Processing, cast, cure, ballistic, mechanical, and safety properties have been evaluated. Phillips Laboratory static-test-fired 70-pound and 800-pound BATES motors. The data indicate that propellant processed with reclaimed AP has nominal properties.

  11. 40 CFR 600.010-86 - Vehicle test requirements and minimum data requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... additional model types established under § 600.207(a)(2), data from each subconfiguration included within the... data requirements. 600.010-86 Section 600.010-86 Protection of Environment ENVIRONMENTAL PROTECTION... requirements and minimum data requirements. (a) For each certification vehicle defined in this part, and for...

  12. 76 FR 59710 - Agency Information Collection Activities: Form N-600; Revision of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... Collection Activities: Form N-600; Revision of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review; Form N- 600, Application for Certificate of... the applicable component of the Department of Homeland Security sponsoring the collection: Form N-600...

  13. 75 FR 70278 - Agency Information Collection Activities: Form N-600, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... Collection Activities: Form N-600, Extension of a Currently Approved Information Collection; Comment Request ACTION: 30-Day Notice of Information Collection Under Review: Form N- 600, Application for Certificate of... Homeland Security sponsoring the collection: Form N-600; U.S. Citizenship and Immigration Services (USCIS...

  14. 76 FR 441 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R...-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F airplanes, certificated in any category...

  15. 9 CFR 319.600 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false [Reserved] 319.600 Section 319.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Snacks, Hors d'Oeuvres, Pizza, and...

  16. 9 CFR 319.600 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false [Reserved] 319.600 Section 319.600 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Snacks, Hors d'Oeuvres, Pizza, and...

  17. 42 CFR 600.120 - Certification of a BHP Blueprint.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... standards for certification. The Secretary will certify a BHP Blueprint provided it meets all of the...) The BHP Blueprint demonstrates adequate planning for the integration of BHP with other insurance...

  18. CURRENT-VOLTAGE CHARACTERISTICS OF THERMALLY ANNEALED Ni/n-GaAs SCHOTTKY CONTACTS

    NASA Astrophysics Data System (ADS)

    Yildirim, Nezir; Turut, Abdulmecit; Dogan, Hulya

    The Schottky barrier type Ni/n-GaAs contacts fabricated by us were thermally annealed at 600∘C and 700∘C for 1min. The apparent barrier height Φap and ideality factor of the diodes were calculated from the forward bias current-voltage characteristic in 60-320K range. The Φap values for the nonannealed and 600∘C and 700∘C annealed diodes were obtained as 0.80, 0.81 and 0.67eV at 300K, respectively. Thus, it has been concluded that the reduced barrier due to the thermal annealing at 700∘C promises some device applications. The current preferentially flows through the lowest barrier height (BH) with the temperature due to the BH inhomogeneities. Therefore, it was seen that the Φap versus (2kT)‑1 plots for the nonannealed and annealed diodes showed the linear behavior according to Gaussian distributions.

  19. 9 CFR 93.600 - Importation of dogs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Importation of dogs. 93.600 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Dogs § 93.600 Importation of dogs. (a) All dogs. Dogs from Angola... applicable requirements of this part: (1) Dogs must be accompanied by a certificate signed by a full-time...

  20. 9 CFR 93.600 - Importation of dogs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Importation of dogs. 93.600 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Dogs § 93.600 Importation of dogs. (a) All dogs. Dogs from any region of...) Dogs must be accompanied by a certificate signed by a full-time salaried veterinary official of the...

  1. 9 CFR 93.600 - Importation of dogs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Importation of dogs. 93.600 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Dogs § 93.600 Importation of dogs. (a) All dogs. Dogs from any region of...) Dogs must be accompanied by a certificate signed by a full-time salaried veterinary official of the...

  2. 77 FR 128 - Agency Information Collection Activities: Form N-600, Revision of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... Collection Activities: Form N-600, Revision of a Currently Approved Information Collection; Comment Request ACTION: 30-Day Notice of Information Collection Under Review: Form N- 600, Application for Certificate of..., and the applicable component of the Department of Homeland Security sponsoring the collection: Form N...

  3. 9 CFR 93.600 - Importation of dogs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Importation of dogs. 93.600 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Dogs § 93.600 Importation of dogs. (a) All dogs. Dogs from Angola... applicable requirements of this part: (1) Dogs must be accompanied by a certificate signed by a full-time...

  4. 9 CFR 93.600 - Importation of dogs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Importation of dogs. 93.600 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Dogs § 93.600 Importation of dogs. (a) All dogs. Dogs from Angola... applicable requirements of this part: (1) Dogs must be accompanied by a certificate signed by a full-time...

  5. 76 FR 58029 - Agency Information Collection Activities: Form N-600K, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... and Issuance of Certificate under Section 322. The Department of Homeland Security, U.S. Citizenship... the Form/Collection: Application for Citizenship and Issuance of Certificate under Section 322. [[Page...

  6. 8 CFR 320.3 - How, where, and what forms and other documents should be filed?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... N-600, Application for Certificate of Citizenship, by the U.S. citizen parent(s) or legal guardian... Child by U.S. citizen adoptive parent(s) or legal guardian. The application must be filed with the... certificate or record; (ii) Marriage certificate of child's parents (if applicable); (iii) If the child's...

  7. Boils

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  8. Hyperpigmentation

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  9. Onycholysis

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  10. Moles

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  11. Lentigines

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  12. Botox

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  13. Vitiligo

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  14. Erysipelas

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  15. 14 CFR 129.115 - Limit of validity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... certificate or a later design change. This section also applies to foreign air carriers or foreign persons... A300-600 Series 30 30,000 FC/67,500 FH A310-200 Series 30 40,000 FC/60,000 FH A310-300 Series 30 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  16. 14 CFR 129.115 - Limit of validity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... certificate or a later design change. This section also applies to foreign air carriers or foreign persons... A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH A310-300 Series 60 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  17. 14 CFR 129.115 - Limit of validity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... certificate or a later design change. This section also applies to foreign air carriers or foreign persons... A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH A310-300 Series 60 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  18. 14 CFR 129.115 - Limit of validity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... certificate or a later design change. This section also applies to foreign air carriers or foreign persons... A300-600 Series 30 30,000 FC/67,500 FH A310-200 Series 30 40,000 FC/60,000 FH A310-300 Series 30 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  19. Kaposi's Sarcoma

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  20. Grover's Disease

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  1. Pityriasis Alba

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  2. Erythema Nodosum

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  3. Prurigo Nodularis

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  4. Bullous Pemphigoid

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  5. Dermatomyositis (DM)

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  6. Lichen Striatus

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  7. Atypical Moles

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  8. Subungual Hematoma

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  9. Dermatology Terms

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  10. The Effectiveness of the National Board Certification as It Relates to the Advanced Placement Calculus AB Exam

    ERIC Educational Resources Information Center

    Antunez, Fernando

    2015-01-01

    This study compared data related to National Board Certification (NBC) of mathematics teachers in a South Florida school district. Data included 1,162 student scores on the 2014 AP Calculus AB exam, student gender, student grade level, and eligibility for free or reduced price lunch (FRL) status. Teachers completed the Standards' Beliefs…

  11. Green Nail Syndrome

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  12. Progressive Pigmentary Purpura

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  13. Fire Ant Bites

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  14. Fungus Infections: Tinea

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  15. Cutaneous Larva Migrans

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  16. WWC Quick Review of the Report "An Evaluation of Teachers Trained through Different Routes to Certification"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2009

    2009-01-01

    This study examined whether having a teacher who chose an alternate route to certification (AC) rather than a teacher who chose a traditional certification route (TC) affects the reading and math achievement of elementary school students. The study included about 2,600 kindergarten through fifth-grade students and their 174 teachers. These…

  17. Bruising Hands and Arms

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  18. Keloids and Hypertrophic Scars

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  19. Fungus Infections: Preventing Recurrence

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  20. Brittle Splitting Nails (Onychoschizia)

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  1. 14 CFR 121.1115 - Limit of validity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... weight is a result of an original type certificate or a later design change. This section also applies to... A300-600 Series 30 30,000 FC/67,500 FH A310-200 Series 30 40,000 FC/60,000 FH A310-300 Series 30 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  2. 14 CFR 121.1115 - Limit of validity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... weight is a result of an original type certificate or a later design change. This section also applies to... A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH A310-300 Series 60 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  3. 14 CFR 121.1115 - Limit of validity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... weight is a result of an original type certificate or a later design change. This section also applies to... A300-600 Series 30 30,000 FC/67,500 FH A310-200 Series 30 40,000 FC/60,000 FH A310-300 Series 30 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  4. 14 CFR 121.1115 - Limit of validity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... weight is a result of an original type certificate or a later design change. This section also applies to... A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH A310-300 Series 60 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  5. American Osteopathic College of Dermatology

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Surgery in the Outback CME CME Attestation ...

  6. In-vessel coolability and retention of a core melt

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Theofanous, T.G.; Liu, C.; Additon, S.

    1997-02-01

    The efficacy of external flooding of a reactor vessel as a severe accident management strategy is assessed for an AP600-like reactor design. The overall approach is based on the Risk Oriented Accident Analysis Methodology (ROAAM), and the assessment includes consideration of bounding scenarios and sensitivity studies, as well as arbitrary parametric evaluations that allow the delineation of the failure boundaries. The technical treatment in this assessment includes: (a) new data on energy flow from either volumetrically heated pools or non-heated layers on top, boiling and critical heat flux in inverted, curved geometries, emissivity of molten (superheated) samples of steel, andmore » chemical reactivity proof tests, (b) a simple but accurate mathematical formulation that allows prediction of thermal loads by means of convenient hand calculations, (c) a detailed model programmed on the computer to sample input parameters over the uncertainty ranges, and to produce probability distributions of thermal loads and margins for departure from nucleate boiling at each angular position on the lower head, and (d) detailed structural evaluations that demonstrate that departure from nucleate boiling is a necessary and sufficient criterion for failure. Quantification of the input parameters is carried out for an AP600-like design, and the results of the assessment demonstrate that lower head failure is {open_quotes}physically unreasonable.{close_quotes} Use of this conclusion for any specific application is subject to verifying the required reliability of the depressurization and cavity-flooding systems, and to showing the appropriateness (in relation to the database presented here, or by further testing as necessary) of the thermal insulation design and of the external surface properties of the lower head, including any applicable coatings.« less

  7. Structure and Function of Your Skin

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  8. Hailey-Hailey Disease (Benign Chronic Pemphigus)

    MedlinePlus

    ... Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. Ulbrich Resident Research Award Daniel Koprince Award Resident Research Paper Award Sponsors Corporate Members Exhibitors Information for Corporate ...

  9. Prurigo Nodularis

    MedlinePlus

    ... Programs Residency Training Resident Calendar Board Certification Grand Rounds Resident Awards AOCD Residency Leadership Award A.P. ... a light brush of clothing sets off a round of severe itch. For many, itching only ends ...

  10. Metabolomic profiles illuminate the efficacy of Chinese herbal Da-Cheng-Qi decoction on acute pancreatitis in rats.

    PubMed

    Li, Juan; Zhu, Shi-Feng; Zhao, Xian-Lin; Liu, Yi-Xia; Wan, Mei-Hua; Guo, Hui; Liu, Yi-Ling; Gong, Han-Lin; Chen, Guang-Yuan; Tang, Wen-Fu

    2015-01-01

    Chinese herbal drug Da-Cheng-Qi decoction (DCQD) has been widely used for decades to treat acute pancreatitis (AP). Previous trials are mostly designed to state the potential mechanisms of the therapeutic effects rather than to detect its whole effect on metabolism. This study aimed to investigate the efficacy of DCQD on metabolism in AP. Twenty-two male adult Sprague-Dawley rats were randomized into three groups. AP was induced by retrograde ductal infusion of 3.5% sodium taurocholate solution in DCQD and AP group, while 0.9% saline solution was used in sham operation (SO) group. Blood samples were obtained 12 h after drug administration and a 600 MHz superconducting Nuclear Magnetic Resonance (NMR) spectrometer was used to detected plasma metabolites. Principal Components Analysis (PCA) and Partial Least Squares-Discriminant Analysis after Orthogonal Signal Correction (OSC-PLS-DA) were applied to analyze the Longitudinal Eddy-delay (LED) and Carr-Purcell-Meiboom-Gill (CPMG) spectra. Differences in concentrations of metabolites among the three groups were detected by OSC-PLS-DA of 1HNMR spectra (both LED and CPMG). Compared with SO group, DCQD group had higher levels of plasma glycerol, glutamic acid, low density lipoprotein (LDL), saturated fatty acid (FA) and lower levels of alanine and glutamine, while the metabolic changes were reversed in the AP group. Our results demonstrated that DCQD was capable of altering the changed concentrations of metabolites in rats with AP and 1HNMR-based metabolomic approach provided a new methodological cue for systematically investigating the efficacies and mechanisms of DCQD in treating AP. Copyright © 2015 IAP and EPC. Published by Elsevier B.V. All rights reserved.

  11. 21 CFR 73.600 - Turmeric.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.600 Turmeric. (a) Identity. (1) The color additive turmeric... to color foods for which standards of identity have been promulgated under section 401 of the act...

  12. 21 CFR 73.600 - Turmeric.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.600 Turmeric. (a) Identity. (1) The color additive turmeric... to color foods for which standards of identity have been promulgated under section 401 of the act...

  13. 21 CFR 73.600 - Turmeric.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.600 Turmeric. (a) Identity. (1) The color additive turmeric... to color foods for which standards of identity have been promulgated under section 401 of the act...

  14. 40 CFR 600.007-08 - Vehicle acceptability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Vehicle acceptability. 600.007-08... FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy and Carbon-Related... Vehicle acceptability. (a) All certification vehicles and other vehicles tested to meet the requirements...

  15. 40 CFR 600.007-80 - Vehicle acceptability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Vehicle acceptability. 600.007-80... FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy and Carbon-Related... Vehicle acceptability. (a) All certification vehicles and other vehicles tested to meet the requirements...

  16. VizieR Online Data Catalog: Brown dwarf surface gravities with Keck/NIRSPEC (Martin , 2017)

    NASA Astrophysics Data System (ADS)

    Martin, E. C.; Mace, G. N.; McLean, I. S.; Logsdon, S. E.; Rice, E. L.; Kirkpatrick, J. D.; Burgasser, A. J.; McGovern, M. R.; Prato, L.

    2017-10-01

    In this paper, we follow up on prior NIR spectroscopy by our group and use a modified Allers & Liu (A13, 2013ApJ...772...79A) method to determine surface gravities for 228 M, L, and T dwarfs. We present medium-resolution (R~20000) J-band spectra of 85 M dwarfs, 92 L dwarfs, and 51 T dwarfs obtained as part of the Keck NIRSPEC Brown Dwarf Spectroscopic Survey (BDSS). Ninety-seven spectra were published previously in McLean+ (2003ApJ...596..561M), Burgasser+ (2003ApJ...592.1186B), McGovern+ (2004ApJ...600.1020M), Rice+ (2010ApJS..186...63R), Kirkpatrick+ (2010, J/ApJS/190/100), Luhman (2012ARA&A..50...65L), Thompson+ (2013PASP..125..809T), Mace+ (2013, J/ApJS/205/6), Mace+ (2013ApJ...777...36M), and Kirkpatrick+ (2014, J/ApJ/783/122), and the remaining 131 are presented here for the first time. Observation information (spanning 1999 Apr to 2015 Mar) for all of the targets in our sample is listed in Table 1. (4 data files).

  17. EPA Traceability Protocol for Assay and Certification of Gaseous Calibration Standards (EPA/600/R-12/531, May 2012)

    EPA Science Inventory

    In 1997, the U.S. Environmental Protection Agency (EPA) in Research Triangle Park, North Carolina, revised its 1993 version of its traceability protocol for the assay and certification of compressed gas and permeation-device calibration standards. The protocol allows producers of...

  18. 21 CFR 73.600 - Turmeric.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.600 Turmeric. (a) Identity. (1) The color additive turmeric... purpose of identity as a color additive only, and shall not be construed as setting forth an official standard for turmeric under section 401 of the act. (2) Color additive mixtures made with turmeric may...

  19. 77 FR 71609 - Agency Information Collection Activities: Application for Citizenship and Issuance of Certificate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... Under Section 322, Form N-600K; Revision of a Currently Approved Collection ACTION: 60-Day Notice... Form/Collection: Application for Citizenship and Issuance of Certificate Under Section 322. (3) Agency... applications for citizenship under section 322 of the Immigration and Nationality Act. (5) An estimate of the...

  20. 48 CFR 952.226-73 - Energy Policy Act target group certification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... is: (1) __ An institution of higher education that meets the requirements of 34 CFR 600.4(a), and has... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Energy Policy Act target....226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert the...

  1. 34 CFR 600.20 - Notice and application procedures for establishing, reestablishing, maintaining, or expanding...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...; (ii) Reestablish eligibility and certification as a private nonprofit, private for-profit, or public... approval of an additional educational program or a location under § 600.10(c). (2) Increase its level of... any wage analysis the institution may have performed, including any consideration of Bureau of Labor...

  2. The Development of the George B. Pegram Award

    NASA Astrophysics Data System (ADS)

    McCay, Myron S.

    1997-11-01

    The George B. Pegram Award for Excellence in the Teaching of Physics was developed by a representative group of SESAPS members over a period of eight years with outstanding contributions as follows: Jesse Beams, APS President, with the advice of Mark Zemansky, AAPT, chose George B. Pegram as the honoree, in view of his excellent teaching career at Columbia University, his graduation from Trinity College--now Duke University, his long period of service as Treasurer of APS, and his active support of the special training program at ORAU; Earle Plyler with the assistance of Edward Burke, Jr., prepared the selection criteria for the recipients of the award; Walter Gordy coordinated the APS approval and initiated the financing of the program; Howard Carr raised the first funds and prepared the initial certificates; William G. Pollard joined the committee and completed the early funding, while preparing the formal certificate and medal; Dr. Vernet Eaton, AAPT President, stimulated the program when he urged the nomination of SESAPS members for the Oersted Award. After his lectures at the 1955 Gainesville meeting, Wendell Holladay instructed the committee to report its recommendations at the next SESAPS meeting. In 1969 SESAPS approved the George B. Pegram Award.

  3. The Need for Increased Critical Technical Skills: Integrating Federal Aviation Administration Airframe and Powerplant Certification in Aircraft Maintenance Force Development

    DTIC Science & Technology

    2011-12-18

    Joaquin Valley College. On-line, Internet. Available at http://www.sjvc.edu/program/Aviation_Maintenance_Technology/ Kansas State University- Salinas ...systems. $- $5,000 $10,000 $15,000 $20,000 $25,000 $30,000 $35,000 $40,000 $45,000 Broward College San Joaquin Valley ...40,000 $45,000 AF A&P Certification Program Broward College San Joaquin Valley College Kansas State University Redstone College

  4. 75 FR 18871 - Agency Information Collection Activities: Form N-600K, Revision of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... and Issuance of Certificate under Section 322. OMB Control No. 1615-0087. The Department of Homeland...) Title of the Form/Collection: Application for Citizenship and Issuance of Certificate under Section 322... citizenship under section 322 of the Immigration and Nationality Act. (5) An estimate of the total number of...

  5. 76 FR 38197 - Agency Information Collection Activities; Form N-600K, Revision of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... and issuance of certificate under section 322. OMB Control No. 1615-0087. The Department of Homeland...) Title of the Form/Collection: Application for Citizenship and Issuance of Certificate under Section 322... citizenship under section 322 of the Immigration and Nationality Act. (5) An estimate of the total number of...

  6. Structural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase.

    PubMed

    Sharma, Arvind; Yogavel, Manickam; Sharma, Amit

    2016-02-01

    Malaria symptoms are driven by periodic multiplication cycles of Plasmodium parasites in human red blood corpuscles (RBCs). Malaria infection still accounts for ~600,000 annual deaths, and hence discovery of both new drug targets and drugs remains vital. In the present study, we have investigated the malaria parasite enzyme diadenosine tetraphosphate (Ap4A) hydrolase that regulates levels of signalling molecules like Ap4A by hydrolyzing them to ATP and AMP. We have tracked the spatial distribution of parasitic Ap4A hydrolase in infected RBCs, and reveal its unusual localization on the infected RBC membrane in subpopulation of infected cells. Interestingly, enzyme activity assays reveal an interaction between Ap4A hydrolase and the parasite growth inhibitor suramin. We also present a high resolution crystal structure of Ap4A hydrolase in apo- and sulphate- bound state, where the sulphate resides in the enzyme active site by mimicking the phosphate of substrates like Ap4A. The unexpected infected erythrocyte localization of the parasitic Ap4A hydrolase hints at a possible role of this enzyme in purinerigic signaling. In addition, atomic structure of Ap4A hydrolase provides insights for selective drug targeting.

  7. Design and Implementation of Secure Area Expansion Scheme for Public Wireless LAN Services

    NASA Astrophysics Data System (ADS)

    Watanabe, Ryu; Tanaka, Toshiaki

    Recently, wireless LAN (WLAN) technology has become a major wireless communication method. The communication bandwidth is increasing and speeds have attained rates exceeding 100 Mbps. Therefore, WLAN technology is regarded as one of the promising communication methods for future networks. In addition, public WLAN connection services can be used in many locations. However, the number of the access points (AP) is insufficient for seamless communication and it cannot be said that users can use the service ubiquitously. An ad-hoc network style connection can be used to expand the coverage area of a public WLAN service. By relaying the user messages among the user nodes, a node can obtain an Internet connection via an AP, even though the node is located outside the AP's direct wireless connection area. Such a coverage area extending technology has many advantages thanks to the feature that no additional infrastructure is required. Therefore, there is a strong demand for this technology as it allows the cost-effective construction of future networks. When a secure ad-hoc routing protocol is used for message exchange in the WLAN service, the message routes are protected from malicious behavior such as route forging and can be maintained appropriately. To do this, however, a new node that wants to join the WLAN service has to obtain information such as the public key certificate and IP address in order to start secure ad-hoc routing. In other words, an initial setup is required for every network node to join the WLAN service properly. Ordinarily, such information should be assigned from the AP. However, new nodes cannot always contact an AP directly. Therefore, there are problems about information delivery in the initial setup of a network node. These problems originate in the multi hop connection based on the ad-hoc routing protocols. In order to realize an expanded area WLAN service, in this paper, the authors propose a secure public key certificate and address provision scheme during the initial setup phase on mobile nodes for the service. The proposed scheme also considers the protection of user privacy. Accordingly, none of the user nodes has to reveal their unique and persistent information to other nodes. Instead of using such information, temporary values are sent by an AP to mobile nodes and used for secure ad-hoc routing operations. Therefore, our proposed scheme prevents tracking by malicious parties by avoiding the use of unique information. Moreover, a test bed was also implemented based on the proposal and an evaluation was carried out in order to confirm performance. In addition, the authors describe a countermeasure against denial of service (DoS) attacks based on the approach to privacy protection described in our proposal.

  8. Construction of novel shuttle expression vectors for gene expression in Bacillus subtilis and Bacillus pumilus.

    PubMed

    Shao, Huanhuan; Cao, Qinghua; Zhao, Hongyan; Tan, Xuemei; Feng, Hong

    2015-01-01

    A native plasmid (pSU01) was detected by genome sequencing of Bacillus subtilis strain S1-4. Two pSU01-based shuttle expression vectors pSU02-AP and pSU03-AP were constructed enabling stable replication in B. subtilis WB600. These vectors contained the reporter gene aprE, encoding an alkaline protease from Bacillus pumilus BA06. The expression vector pSU03-AP only possessed the minimal replication elements (rep, SSO, DSO) and exhibited more stability on structure, suggesting that the rest of the genes in pSU01 (ORF1, ORF2, mob, hsp) were unessential for the structural stability of plasmid in B. subtilis. In addition, recombinant production of the alkaline protease was achieved more efficiently with pSU03-AP whose copy number was estimated to be more than 100 per chromosome. Furthermore, pSU03-AP could also be used to transform and replicate in B. pumilus BA06 under selective pressure. In conclusion, pSU03-AP is expected to be a useful tool for gene expression in Bacillus subtilis and B. pumilus.

  9. A computerized method for automated identification of erect posteroanterior and supine anteroposterior chest radiographs

    NASA Astrophysics Data System (ADS)

    Kao, E.-Fong; Lin, Wei-Chen; Hsu, Jui-Sheng; Chou, Ming-Chung; Jaw, Twei-Shiun; Liu, Gin-Chung

    2011-12-01

    A computerized scheme was developed for automated identification of erect posteroanterior (PA) and supine anteroposterior (AP) chest radiographs. The method was based on three features, the tilt angle of the scapula superior border, the tilt angle of the clavicle and the extent of radiolucence in lung fields, to identify the view of a chest radiograph. The three indices Ascapula, Aclavicle and Clung were determined from a chest image for the three features. Linear discriminant analysis was used to classify PA and AP chest images based on the three indices. The performance of the method was evaluated by receiver operating characteristic analysis. The proposed method was evaluated using a database of 600 PA and 600 AP chest radiographs. The discriminant performances Az of Ascapula, Aclavicle and Clung were 0.878 ± 0.010, 0.683 ± 0.015 and 0.962 ± 0.006, respectively. The combination of the three indices obtained an Az value of 0.979 ± 0.004. The results indicate that the combination of the three indices could yield high discriminant performance. The proposed method could provide radiologists with information about the view of chest radiographs for interpretation or could be used as a preprocessing step for analyzing chest images.

  10. Personality Traits and Intelligence Predict Academic School Grades

    ERIC Educational Resources Information Center

    Furnham, Adrian; Monsen, Jeremy

    2009-01-01

    This study examines the extent to which personality traits and intelligence scores predict school level academic performance (AP), (British GCSE: General Certificate of Secondary Education; America Grade 10) in different disciplines. The participant sample consisted of approximately 250 school pupils from three schools in the South East of…

  11. Methane Synthesis from Automotive Paint Sludge via Microwave Assisted Pyrolysis

    NASA Astrophysics Data System (ADS)

    Rosli, N. L.; Rahman, N. Abd; Kadri, A.

    2018-05-01

    Methane gas, which has one atom of carbon and four atoms of hydrogen, is a valuable energy resource, which can be used in the energy sector. The purpose of this research work is to identify methane synthesis from Automotive Paint Sludge (APS) using microwave assisted pyrolysis. APS is known as a hazardous waste since it contains various chemicals that categorized as heavy metals and toxic substances. A modified conventional kitchen microwave was used to pyrolise the APS. The microwave was set with the power level of 600 W and 50 minutes radiation time. Through the experiment, pyrogas was collected into tedlar bag and was analysed using Gas Chromatography with Flame Ionization Detector (GC-FID). Results from the GC-FID were shown that the retention time of 3.3583, 3.2733, and 3.2267 min are proved to be methane gas. The results obtained are resembled with the results from the literature. This indicates methane gas was presented in the pyrogas of pyrolysis of APS and there is a possibility of producing methane gas. The research study suggests that it is possible to synthesize methane gas from the APS via microwave assisted pyrolysis, and in the meantime reduce the volume of APS in the landfill.

  12. Effect of soy saponin on the growth of human colon cancer cells

    PubMed Central

    Tsai, Cheng-Yu; Chen, Yue-Hwa; Chien, Yi-Wen; Huang, Wen-Hsuan; Lin, Shyh-Hsiang

    2010-01-01

    AIM: To investigate the effect of extracted soybean saponins on the growth of human colon cancer cells. METHODS: WiDr human colon cancer cells were treated with 150, 300, 600 or 1200 ppm of soy saponin to determine the effect on cell growth, cell morphology, alkaline phosphatase (AP) and protein kinase C (PKC) activities, and P53 protein, c-Fos and c-Jun gene expression. RESULTS: Soy saponin decreased the number of viable cells in a dose-dependent manner and suppressed 12-O-tetradecanol-phorbol-13-acetate-stimulated PKC activity (P < 0.05). Cells treated with saponins developed cytoplasmic vesicles and the cell membrane became rougher and more irregular in a dose-dependent manner, and eventually disassembled. At 600 and 1200 ppm, the activity of AP was increased (P < 0.05). However, the apoptosis markers such as c-Jun and c-Fos were not significantly affected by saponin. CONCLUSION: Soy saponin may be effective in preventing colon cancer by affecting cell morphology, cell proliferation enzymes, and cell growth. PMID:20632438

  13. Purpose, Principles, and Challenges of the NASA Engineering and Safety Center

    NASA Technical Reports Server (NTRS)

    Gilbert, Michael G.

    2016-01-01

    NASA formed the NASA Engineering and Safety Center in 2003 following the Space Shuttle Columbia accident. It is an Agency level, program-independent engineering resource supporting NASA's missions, programs, and projects. It functions to identify, resolve, and communicate engineering issues, risks, and, particularly, alternative technical opinions, to NASA senior management. The goal is to help ensure fully informed, risk-based programmatic and operational decision-making processes. To date, the NASA Engineering and Safety Center (NESC) has conducted or is actively working over 600 technical studies and projects, spread across all NASA Mission Directorates, and for various other U.S. Government and non-governmental agencies and organizations. Since inception, NESC human spaceflight related activities, in particular, have transitioned from Shuttle Return-to-Flight and completion of the International Space Station (ISS) to ISS operations and Orion Multi-purpose Crew Vehicle (MPCV), Space Launch System (SLS), and Commercial Crew Program (CCP) vehicle design, integration, test, and certification. This transition has changed the character of NESC studies. For these development programs, the NESC must operate in a broader, system-level design and certification context as compared to the reactive, time-critical, hardware specific nature of flight operations support.

  14. The Cost-Effectiveness of Antibiotic Prophylaxis for Patients at Risk of Infective Endocarditis.

    PubMed

    Franklin, Matthew; Wailoo, Allan; Dayer, Mark J; Jones, Simon; Prendergast, Bernard; Baddour, Larry M; Lockhart, Peter B; Thornhill, Martin H

    2016-11-15

    In March 2008, the National Institute for Health and Care Excellence recommended stopping antibiotic prophylaxis (AP) for those at risk of infective endocarditis (IE) undergoing dental procedures in the United Kingdom, citing a lack of evidence of efficacy and cost-effectiveness. We have performed a new economic evaluation of AP on the basis of contemporary estimates of efficacy, adverse events, and resource implications. A decision analytic cost-effectiveness model was used. Health service costs and benefits (measured as quality-adjusted life-years) were estimated. Rates of IE before and after the National Institute for Health and Care Excellence guidance were available to estimate prophylactic efficacy. AP adverse event rates were derived from recent UK data, and resource implications were based on English Hospital Episode Statistics. AP was less costly and more effective than no AP for all patients at risk of IE. The results are sensitive to AP efficacy, but efficacy would have to be substantially lower for AP not to be cost-effective. AP was even more cost-effective in patients at high risk of IE. Only a marginal reduction in annual IE rates (1.44 cases in high-risk and 33 cases in all at-risk patients) would be required for AP to be considered cost-effective at £20 000 ($26 600) per quality-adjusted life-year. Annual cost savings of £5.5 to £8.2 million ($7.3-$10.9 million) and health gains >2600 quality-adjusted life-years could be achieved from reinstating AP in England. AP is cost-effective for preventing IE, particularly in those at high risk. These findings support the cost-effectiveness of guidelines recommending AP use in high-risk individuals. © 2016 The Authors.

  15. Simultaneous detection of the three ilarviruses affecting stone fruit trees by nonisotopic molecular hybridization and multiplex reverse-transcription polymerase chain reaction.

    PubMed

    Saade, M; Aparicio, F; Sánchez-Navarro, J A; Herranz, M C; Myrta, A; Di Terlizzi, B; Pallás, V

    2000-12-01

    ABSTRACT The three most economically damaging ilarviruses affecting stone fruit trees on a worldwide scale are the related Prunus necrotic ringspot virus (PNRSV), Prune dwarf virus (PDV), and Apple mosaic virus (ApMV). Nonisotopic molecular hybridization and multiplex reverse-transcription polymerase chain reaction (RT-PCR) methodologies were developed that could detect all these viruses simultaneously. The latter technique was advantageous because it was discriminatory. For RT-PCR, a degenerate antisense primer was designed which was used in conjunction with three virus-specific sense primers. The amplification efficiencies for the detection of the three viruses in the multiplex RT-PCR reaction were identical to those obtained in the single RT-PCR reactions for individual viruses. This cocktail of primers was able to amplify sequences from all of the PNRSV, ApMV, and PDV isolates tested in five Prunus spp. hosts (almond, apricot, cherry, peach, and plum) occurring naturally in single or multiple infections. For ApMV isolates, differences in the electrophoretic mobilities of the PCR products were observed. The nucleotide sequence of the amplified products of two representative ApMV isolates was determined, and comparative analysis revealed the existence of a 28-nucleotide deletion in the sequence of isolates showing the faster electrophoretic mobility. To our knowledge, this is the first report on the simultaneous detection of three plant viruses by multiplex RT-PCR in woody hosts. This multiplex RT-PCR could be a useful time and cost saving method for indexing these three ilarviruses, which damage stone fruit tree yields, and for the analysis of mother plants in certification programs.

  16. 50 CFR 600.135 - Meeting procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... timely requests for language interpreters or other auxiliary aids at public meetings. (b) Emergency... candidates for appointment to AP, SSC, and other subsidiary bodies and public decorum or medical conditions of members of a Council or its subsidiary bodies. In deciding whether to close a portion of a meeting...

  17. 50 CFR 600.135 - Meeting procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... timely requests for language interpreters or other auxiliary aids at public meetings. (b) Emergency... candidates for appointment to AP, SSC, and other subsidiary bodies and public decorum or medical conditions of members of a Council or its subsidiary bodies. In deciding whether to close a portion of a meeting...

  18. 75 FR 81138 - Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... [CMS-1510-CN2] RIN 0938-AP88 Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011; Changes in Certification Requirements for Home Health Agencies and Hospices AGENCY... ``Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011; Changes in...

  19. 77 FR 31892 - Request for Certification of Compliance-Rural Industrialization Loan and Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ... skilled nursing facility and a 3,600 square foot maintenance building in Picayune, Mississippi. The NAICS industry code for this enterprise is: 623110 (nursing care facilities). DATES: All interested parties may...

  20. Approximate entropy of human respiratory movement during eye-closed waking and different sleep stages.

    PubMed

    Burioka, Naoto; Cornélissen, Germaine; Halberg, Franz; Kaplan, Daniel T; Suyama, Hisashi; Sako, Takanori; Shimizu, Eiji

    2003-01-01

    The breath-to-breath variability of respiratory parameters changes with sleep stage. This study investigates any alteration in the approximate entropy (ApEn) of respiratory movement as a gauge of complexity in respiration, by stage of consciousness, in the light of putative brain interactions. Eight healthy men, who were between the ages of 23 and 29 years, were investigated. The signals of chest wall movement and EEG were recorded from 10:30 PM to 6:00 AM. After analog-to-digital conversion, the ApEn of respiratory movement (3 min) and EEG (20 s) were computed. Surrogate data were tested for nonlinearity in the original time series. The most impressive reduction in the ApEn of respiratory movement was associated with stage IV sleep, when the ApEn of the EEG was also statistically significantly decreased. A statistically significant linear relation is found between the ApEn of both variables. Surrogate data indicated that respiratory movement had nonlinear properties during all stages of consciousness that were investigated. Respiratory movement and EEG signals are more regular during stage IV sleep than during other stages of consciousness. The change in complexity described by the ApEn of respiration depends in part on the ApEn of the EEG, suggesting the involvement of nonlinear dynamic processes in the coordination between brain and lungs.

  1. Characterization of the chemical composition of Adenostemma lavenia (L.) Kuntze and Adenostemma platyphyllum Cass

    NASA Astrophysics Data System (ADS)

    Fauzan, A.; Praseptiangga, D.; Hartanto, R.; Pujiasmanto, B.

    2018-01-01

    The purpose of this study was to characterize the chemical compounds of Adenostemma lavenia (L.) Kuntze (Al) and Adenostemma platyphyllum Cass (Ap) using Pyrolysis-gas chromatography/mass spectrometry (Py-GCMS) and proximate analysis. Two species of Adenostemma samples (roots, stem and leaves) about 1 mg was pyrolyzed directly at the optimum temperature of 600°C. Py-GCMS was relatively fast, easy to use and without samples preparation and identification of the chemical compounds was carried out by comparison of the mass spectra obtained with those stored in Wiley 7th libraries. The data of proximate analysis were statistically analysed using Friedman test followed and hierarchical cluster analysis (HCA) for data of Py-GCMS. The result of proximate analysis showed that A. lavenia (L.) Kuntze (Al) and A. platyphyllum Cass (Ap) contained 8.27% (Al) and 9.18% (Ap) of water, 11.52% (Al) and 17.84% (Ap) of protein, 5.67% (Al) and 6.33% (Ap) of fat, and 17.32% (Al) and 19.94 (Ap) of ash. Amines, aldehydes, fatty acids, terpenoids-steroids, alkaloids, aromatic and aliphatic hydrocarbons, phenolic, and oligopeptides as part of 125 chemical compounds of each species are identified by Py-GCMS analysis. Hierarchical cluster analysis of pyrolysis products indicate not similitary of major chemical compounds of two Adenostemma species.

  2. Synthesis and characterization of pure strontium apatite particles and nanoporous scaffold prepared by dextrose-templated method

    NASA Astrophysics Data System (ADS)

    Ma, Xiaoyu; Liu, Yongjia; Zhu, Bangshang

    2018-02-01

    Strontium shows an increasing interest on bone formation and bone resorption prevention. Here, pure apatite strontium (Ap-SrOH) [Sr5(PO4)3(OH), strontium hydroxyapatite] particles were prepared by the precipitation method using Sr(NO3)2 · 6H2O and (NH4)2HPO4 as reagents. Scanning electron microscope, transmission electron microscope combined with electron diffraction, X-ray diffraction, Fourier transform infrared spectra (FTIR), variable temperature FTIR and thermo gravimetric analysis were employed to evaluate the crystalline structure, chemical composition, and thermal stability of the Ap-SrOH particles. The results show that phase pure Ap-SrOH particles were prepared by wet precipitation. The obtained Ap-SrOH particles are single crystal in phase structure, they have hexagonal fusiform shape, and their size is about 30-180 nm in diameter, and 0.4-2.5 μm in length. The cell MTT assay evaluations indicate that Ap-SrOH particles have very low cytotoxicity. Furthermore, nanoporous Ap-SrOH scaffolds were synthesized by anhydrous dextrose template method. After mixed 5-10 wt% of anhydrous dextrose with Ap-SrOH particles, pressed into discs, and sintered in microwave muffle furnace at 600 °C, the scaffolds with both nanoporous and nanotopography were formed. Cell culture of MC3T3-E1 osteoblasts in vitro show cells grow well on nanoporous Ap-SrOH scaffold. Therefore, Ap-SrOH particles and their nanoporous scaffolds are promising biomaterials for bone repairing and bone disease (e.g. osteoporosis) healing.

  3. 76 FR 9502 - Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... [CMS-1510-F2] RIN 0938-AP88 Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011; Changes in Certification Requirements for Home Health Agencies and Hospices; Correction... set forth an update to the Home Health Prospective Payment System (HH PPS) rates, including: The...

  4. 78 FR 41005 - Airworthiness Directives; Vulcanair S.p.A. Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... Internet at http://www.regulations.gov ; or in person at the Docket Management Facility between 9 a.m. and... after receipt. FOR FURTHER INFORMATION CONTACT: Mike Kiesov, Aerospace Safety Engineer, FAA, Small...,'' AP68TP 600 ``VIATOR,'' and P68 ``OBSERVER 2'' airplanes. Since we issued AD 2008-24-11 (73 FR 72314...

  5. Amorphous silicon photovoltaic manufacturing technology, phase 2A

    NASA Astrophysics Data System (ADS)

    Duran, G.; Mackamul, K.; Metcalf, D.

    1995-01-01

    Utility Power Group (UPG), and its lower-tier subcontractor, Advanced Photovoltaic Systems, Inc. (APS) have conducted efforts in developing their manufacturing lines. UPG has focused on the automation of encapsulation and termination processes developed in Phase 1. APS has focused on completion of the encapsulation and module design tasks, while continuing the process and quality control and automation projects. The goal is to produce 55 watt (stabilized) EP50 modules in a new facility. In the APS Trenton EUREKA manufacturing facility, APS has: (1) Developed high throughput lamination procedures; (2) Optimized existing module designs; (3) Developed new module designs for architectural applications; (4) Developed enhanced deposition parameter control; (5) Designed equipment required to manufacture new EUREKA modules developed during Phase II; (6) Improved uniformity of thin-film materials deposition; and (7) Improved the stabilized power output of the APS EP50 EUREKA module to 55 watts. In the APS Fairfield EUREKA manufacturing facility, APS has: (1) Introduced the new products developed under Phase 1 into the APS Fairfield EUREKA module production line; (2) Increased the extent of automation in the production line; (3) Introduced Statistical Process Control to the module production line; and (4) Transferred-progress made in the APS Trenton facility into the APS Fairfield facility.

  6. Test Report for Cesium and Solids Removal from an 11.5L Composite of Archived Hanford Double Shell Tank Supernate for Off-Site Disposal

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Doll, Stephanie R.; Cooke, Gary A.

    The 222-S Laboratory blended supernate waste from Hanford Tanks 241-AN-101, 241-AN- 106, 241-AP-105, 241-AP-106, 241-AP-107, and 241-AY-101 from the hot cell archive to create a bulk composite. The composite was blended with 600 mL 19.4 M NaOH, which brought the total volume to approximately 11.5 L (3 gal). The composite was filtered to remove solids and passed through spherical resorcinol-formaldehyde ion-exchange resin columns to remove cesium. The composite masses were tracked as a treatability study. Samples collected before, during, and after the ion-exchange process were characterized for a full suite of analytes (inorganic, organic, and radionuclides) to aid in themore » classification of the waste for shipping, receiving, treatment, and disposal determinations.« less

  7. Test Report for Cesium and Solids Removal from an 11.5L Composite of Archived Hanford Double Shell Tank Supernate for Off-Site Disposal.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Doll, S. R.; Cooke, G. A.

    The 222-S Laboratory blended supernate waste from Hanford Tanks 241-AN-101, 241-AN- 106, 241-AP-105, 241-AP-106, 241-AP-107, and 241-AY-101 from the hot cell archive to create a bulk composite. The composite was blended with 600 mL 19.4 M NaOH, which brought the total volume to approximately 11.5 L (3 gal). The composite was filtered to remove solids and passed through spherical resorcinol-formaldehyde ion-exchange resin columns to remove cesium. The composite masses were tracked as a treatability study. Samples collected before, during, and after the ion exchange process were characterized for a full suite of analytes (inorganic, organic, and radionuclides) to aid inmore » the classification of the waste for shipping, receiving, treatment, and disposal determinations.« less

  8. Correlation of nitric oxide and other free radicals with the severity of acute pancreatitis and complicated systemic inflammatory response syndrome.

    PubMed

    Que, Ri-sheng; Cao, Li-ping; Ding, Guo-ping; Hu, Jun-an; Mao, Ke-jie; Wang, Gui-feng

    2010-05-01

    To investigate the correlation of nitric oxide (NO) and other free radicals with the severity of acute pancreatitis (AP) and complicated systemic inflammatory response syndrome (SIRS). Fifty AP patients (24 simple AP patients and 26 patients with AP complicated by SIRS) were involved in the study. Fifty healthy volunteers were included as controls. Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were evaluated, and plasma NO, plasma lipid peroxides, plasma vitamin E, plasma beta-carotene, whole-blood glutathione (GSH), and the activity of plasma GSH peroxidase were measured. Compared with the control group, the APACHE II scores heightened in the AP group, and the SIRS group had the highest APACHE II scores (P < 0.005, P < 0.001, respectively). Plasma NO and plasma lipid peroxides increased with the heightening APACHE II scores, demonstrating a significant linear positive correlation (r = 0.618, r = 0.577, respectively; P < 0.001). Plasma vitamin E, plasma beta-carotene, whole-blood GSH, and the activity of plasma GSH peroxidase decreased with the heightening APACHE II scores, demonstrating a significant linear negative correlation (r = -0.600, r = -0.609, r = -0.559, r = -0.592, respectively; P < 0.001). Nitric oxide and other free radicals take part in the aggravation of oxidative stress and oxidative injury and may play important roles in the pathogenesis of AP and SIRS. It may be valuable to measure free radicals to predict the severity of AP.

  9. 34 CFR 600.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... educational program that meets the agency's established requirements. Award year: The period of time from July... permanent in nature; (2) Offers courses in educational programs leading to a degree, certificate, or other recognized educational credential; (3) Has its own faculty and administrative or supervisory organization...

  10. Developing a Nationwide K-12 Outreach Model: Physiology Understanding (PhUn) Week 10 Years Later

    ERIC Educational Resources Information Center

    Stieben, Margaret; Halpin, Patricia A.; Matyas, Marsha Lakes

    2017-01-01

    Since 2005, nearly 600 Physiology Understanding Week (PhUn Week) events have taken place across the U.S., involving American Physiological Society (APS) members in K-12 outreach. The program seeks to build student understanding of physiology and physiology careers, assist teachers in recognizing physiology in their standards-based curriculum, and…

  11. 10 CFR 50.150 - Aircraft impact assessment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13, 2009; (B) Renewal of standard design certifications in effect on July 13, 2009 which have not..., standard design approval, or manufactured reactor; or (B) Reference a standard design certification issued... certification or standard design approval; or (B) Reference a standard design certification issued before July...

  12. 10 CFR 50.150 - Aircraft impact assessment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13, 2009; (B) Renewal of standard design certifications in effect on July 13, 2009 which have not..., standard design approval, or manufactured reactor; or (B) Reference a standard design certification issued... certification or standard design approval; or (B) Reference a standard design certification issued before July...

  13. 10 CFR 50.150 - Aircraft impact assessment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13, 2009; (B) Renewal of standard design certifications in effect on July 13, 2009 which have not..., standard design approval, or manufactured reactor; or (B) Reference a standard design certification issued... certification or standard design approval; or (B) Reference a standard design certification issued before July...

  14. 10 CFR 50.150 - Aircraft impact assessment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13, 2009; (B) Renewal of standard design certifications in effect on July 13, 2009 which have not..., standard design approval, or manufactured reactor; or (B) Reference a standard design certification issued... certification or standard design approval; or (B) Reference a standard design certification issued before July...

  15. 29 CFR 541.600 - Amount of salary required.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES... employed, as provided in § 541.204(a)(1). (d) In the case of computer employees, the compensation... license or certificate permitting the practice of law or medicine or any of their branches and are...

  16. 29 CFR 541.600 - Amount of salary required.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES... employed, as provided in § 541.204(a)(1). (d) In the case of computer employees, the compensation... license or certificate permitting the practice of law or medicine or any of their branches and are...

  17. 29 CFR 541.600 - Amount of salary required.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES... employed, as provided in § 541.204(a)(1). (d) In the case of computer employees, the compensation... license or certificate permitting the practice of law or medicine or any of their branches and are...

  18. 29 CFR 541.600 - Amount of salary required.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES... employed, as provided in § 541.204(a)(1). (d) In the case of computer employees, the compensation... license or certificate permitting the practice of law or medicine or any of their branches and are...

  19. 29 CFR 541.600 - Amount of salary required.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES... employed, as provided in § 541.204(a)(1). (d) In the case of computer employees, the compensation... license or certificate permitting the practice of law or medicine or any of their branches and are...

  20. 75 FR 258 - Airworthiness Directives; Bombardier, Inc. (Type Certificate Previously Held by Bombardier...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ....; Canadair) Model CL-600- 2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation... the AD docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety..., January 5, 2010 / Proposed Rules#0;#0; [[Page 258

  1. Incipient I Fire Brigade Training & Certification.

    ERIC Educational Resources Information Center

    Anoka-Hennepin Technical Coll., Minneapolis, MN.

    This document contains course materials for the minimum general and Koch-specific requirements for the fire suppression training and education portion of the integrated industrial emergency response team training program. The various levels of performance were developed with the National Fire standard 600, Private Fire Brigades. The training is…

  2. 10 CFR 51.55 - Environmental report-standard design certification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Environmental report-standard design certification. 51.55... Implementing Section 102(2) Environmental Reports-Production and Utilization Facilities § 51.55 Environmental report—standard design certification. (a) Each applicant for a standard design certification under...

  3. Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis

    PubMed Central

    Thornhill, Martin H.; Dayer, Mark J.; Prendergast, Bernard; Baddour, Larry M.; Jones, Simon; Lockhart, Peter B.

    2015-01-01

    Objectives Antibiotic prophylaxis (AP) administration prior to invasive dental procedures has been a leading focus of infective endocarditis prevention. However, there have been long-standing concerns about the risk of adverse drug reactions as a result of this practice. The objective of this study was to identify the incidence and nature of adverse reactions to amoxicillin and clindamycin prophylaxis to prevent infective endocarditis. Methods We obtained AP prescribing data for England from January 2004 to March 2014 from the NHS Business Services Authority, and adverse drug reaction data from the Medicines and Healthcare Products Regulatory Agency's Yellow Card reporting scheme for prescriptions of the standard AP protocol of a single 3 g oral dose of amoxicillin or a single 600 mg oral dose of clindamycin for those allergic to penicillin. Results The reported adverse drug reaction rate for amoxicillin AP was 0 fatal reactions/million prescriptions (in fact 0 fatal reactions for nearly 3 million prescriptions) and 22.62 non-fatal reactions/million prescriptions. For clindamycin, it was 13 fatal and 149 non-fatal reactions/million prescriptions. Most clindamycin adverse drug reactions were Clostridium difficile infections. Conclusions AP adverse drug reaction reporting rates in England were low, particularly for amoxicillin, and lower than previous estimates. This suggests that amoxicillin AP is comparatively safe for patients without a history of amoxicillin allergy. The use of clindamycin AP was, however, associated with significant rates of fatal and non-fatal adverse drug reactions associated with C. difficile infections. These were higher than expected and similar to those for other doses, durations and routes of clindamycin administration. PMID:25925595

  4. Commercialization and Field Distribution of Smart Pedestrian Call Signals

    DOT National Transportation Integrated Search

    2010-06-01

    The research on this project resulted in a new design for an accessible pedestrian system (APS) that uses Ethernet communications to implement a distributed control system. Present APS designs represent a safety risk factor by APS systems having unde...

  5. 48 CFR 50.205-3 - Authorization of offers contingent upon SAFETY Act designation or certification before contract...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...— (i) For offers contingent upon SAFETY Act designation, a pre-qualification designation notice or a block designation; or (ii) For offers contingent upon SAFETY Act certification, a block certification... contingent upon SAFETY Act designation or certification before contract award. 50.205-3 Section 50.205-3...

  6. 78 FR 47233 - Airworthiness Directives; The Boeing Company Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ...-0670; Directorate Identifier 2013-NM-081-AD] RIN 2120-AA64 Airworthiness Directives; The Boeing Company...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737-600, -700, -800, -900, and -900ER airplanes modified by particular supplemental type certificates (STC...

  7. Complex performance during exposure to high temperatures.

    DOT National Transportation Integrated Search

    1969-06-01

    The effects of high temperature on psychomotor performance and physiological function were studied on male pilots (age 30-51) holding a current medical certificate. A total of 41 runs were made at neutral (23.8C (75F), or hot (60.0C (140F), 71.1C (16...

  8. 40 CFR 600.311-12 - Determination of values for fuel economy labels.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of available information from the certification database for all model types. Specifically, the mean... vehicle cannot be charged at the higher voltage. (l) California-specific values. If the Administrator... fuel economy or other label values from those intended for sale in other states, the Administrator will...

  9. 78 FR 21817 - Amendment of Restricted Area R-6601; Fort A.P. Hill, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ...; Airspace Docket No. 12-AEA-7] RIN 2120-AA66 Amendment of Restricted Area R-6601; Fort A.P. Hill, VA AGENCY... limits and time of designation of restricted area R-6601, Fort A.P. Hill, VA. The U.S. Army requested... limits and increase the time of designation of restricted area R-6601, Fort A.P. Hill, VA, (77 FR 35308...

  10. 47 CFR 2.960 - Designation of Telecommunication Certification Bodies (TCBs).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Designation of Telecommunication Certification Bodies (TCBs). 2.960 Section 2.960 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY... Telecommunication Certification Bodies (tcbs) § 2.960 Designation of Telecommunication Certification Bodies (TCBs...

  11. 47 CFR 2.960 - Designation of Telecommunication Certification Bodies (TCBs).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Designation of Telecommunication Certification Bodies (TCBs). 2.960 Section 2.960 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY... Telecommunication Certification Bodies (tcbs) § 2.960 Designation of Telecommunication Certification Bodies (TCBs...

  12. Forty research issues for the redesign of animal production systems in the 21st century.

    PubMed

    Dumont, B; González-García, E; Thomas, M; Fortun-Lamothe, L; Ducrot, C; Dourmad, J Y; Tichit, M

    2014-08-01

    Agroecology offers a scientific and operational framework for redesigning animal production systems (APS) so that they better cope with the coming challenges. Grounded in the stimulation and valorization of natural processes to reduce inputs and pollutions in agroecosystems, it opens a challenging research agenda for the animal science community. In this paper, we identify key research issues that define this agenda. We first stress the need to assess animal robustness by measurable traits, to analyze trade-offs between production and adaptation traits at within-breed and between-breed level, and to better understand how group selection, epigenetics and animal learning shape performance. Second, we propose research on the nutritive value of alternative feed resources, including the environmental impacts of producing these resources and their associated non-provisioning services. Third, we look at how the design of APS based on agroecological principles valorizes interactions between system components and promotes biological diversity at multiple scales to increase system resilience. Addressing such challenges requires a collection of theories and models (concept-knowledge theory, viability theory, companion modeling, etc.). Acknowledging the ecology of contexts and analyzing the rationales behind traditional small-scale systems will increase our understanding of mechanisms contributing to the success or failure of agroecological practices and systems. Fourth, the large-scale development of agroecological products will require analysis of resistance to change among farmers and other actors in the food chain. Certifications and market-based incentives could be an important lever for the expansion of agroecological alternatives in APS. Finally, we question the suitability of current agriculture extension services and public funding mechanisms for scaling-up agroecological practices and systems.

  13. Incidence and mortality of acute and chronic pancreatitis in the Netherlands: a nationwide record-linked cohort study for the years 1995-2005.

    PubMed

    Spanier, B W Marcel; Bruno, Marco J; Dijkgraaf, Marcel G W

    2013-05-28

    To analyze trends in incidence and mortality of acute pancreatitis (AP) and chronic pancreatitis (CP) in the Netherlands and for international standard populations. A nationwide cohort is identified through record linkage of hospital data for AP and CP, accumulated from three nationwide Dutch registries: the hospital discharge register, the population register, and the death certificate register. Sex- and age-group specific incidence rates of AP and CP are defined for the period 2000-2005 and mortality rates of AP and CP for the period 1995-2005. Additionally, incidence and mortality rates over time are reported for Dutch and international (European and World Health Organization) standard populations. Incidence of AP per 100000 persons per year increased between 2000 and 2005 from 13.2 (95%CI: 12.6-13.8) to 14.7 (95%CI: 14.1-15.3). Incidence of AP for males increased from 13.8 (95%CI: 12.9-14.7) to 15.2 (95%CI: 14.3-16.1), for females from 12.7 (95%CI: 11.9-13.5) to 14.2 (95%CI: 13.4-15.1). Irregular patterns over time emerged for CP. Overall mean incidence per 100000 persons per year was 1.77, for males 2.16, and for females 1.4. Mortality for AP fluctuated during 1995-2005 between 6.9 and 11.7 per million persons per year and was almost similar for males and females. Concerning CP, mortality for males fluctuated between 1.1 (95%CI: 0.6-2.3) and 4.0 (95%CI: 2.8-5.8), for females between 0.7 (95%CI: 0.3-1.6) and 2.0 (95%CI: 1.2-3.2). Incidence and mortality of AP and CP increased markedly with age. Standardized rates were lowest for World Health Organization standard population. Incidence of AP steadily increased while incidence of CP fluctuated. Mortality for both AP and CP remained fairly stable. Patient burden and health care costs probably will increase because of an ageing Dutch population.

  14. 75 FR 59281 - Recognition of Foreign Certificates Under the International Convention on Standards of Training...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ...; (B) A mobile offshore drilling unit or other vessel engaged in support of exploration, exploitation, or production of offshore mineral energy resources operating beyond the water above the outer... for: (A) An offshore supply vessel or other similarly engaged vessel of less than 1,600 gross tons as...

  15. 75 FR 12470 - Automotive Fuel Ratings, Certification and Posting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... the Secretary, Room H-135 (Annex M), 600 Pennsylvania Avenue, N.W., Washington, D.C. 20580, in the... with the Petroleum Marketing Practices Act (``PMPA''), 15 U.S.C. 2801 et seq.\\3\\ The Rule originally... the specific labeling requirements for biodiesel fuels required by Section 205 of EISA, 42 U.S.C...

  16. 16 CFR Appendix to Part 600 - Commentary on the Fair Credit Reporting Act

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... no other purpose.) For example, a claims reporting service could use such a certification to avoid..., in item 5-C under this subsection.) Reports provided to insurers by claims investigation services... their individual customers from an outside source (such as a bank or a finance company). The...

  17. 76 FR 53046 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation... Manager, New York Aircraft Certification Office (ACO), ANE-170, FAA, or Transport Canada Civil Aviation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011...

  18. 75 FR 70109 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440), CL...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    .... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... York Aircraft Certification Office, FAA; or Transport Canada Civil Aviation (TCCA) (or its delegated... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

  19. 76 FR 24360 - Airworthiness Directives; Airbus Model A340-200, -300, -500, and -600 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    .... The MCAI describes the unsafe condition as: * * * * * The revision 01 of Airbus A340 ALS... distributed in the Airbus A340 Airworthiness Limitations Section (ALS). The airworthiness limitations applicable to the Certification Maintenance Requirements (CMR) are given in Airbus A340 ALS Part 3, which is...

  20. 31 CFR Appendix A to Part 344 - Early Redemption Market Charge Formulas and Examples for Subscriptions From December 28, 1976...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... that a $600,000 note is issued on July 1, 1985, to mature on July 1, 1995. Interest is payable at a... that a $50,000 certificate of indebtedness is issued on March 1, 1987, to mature on November 1, 1987...

  1. 31 CFR Appendix A to Part 344 - Early Redemption Market Charge Formulas and Examples for Subscriptions From December 28, 1976...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... that a $600,000 note is issued on July 1, 1985, to mature on July 1, 1995. Interest is payable at a... that a $50,000 certificate of indebtedness is issued on March 1, 1987, to mature on November 1, 1987...

  2. 31 CFR Appendix A to Part 344 - Early Redemption Market Charge Formulas and Examples for Subscriptions From December 28, 1976...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... that a $600,000 note is issued on July 1, 1985, to mature on July 1, 1995. Interest is payable at a... that a $50,000 certificate of indebtedness is issued on March 1, 1987, to mature on November 1, 1987...

  3. 47 CFR 101.139 - Authorization of transmitters.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assigned frequency in the 890-940 MHz band and has not been certificated, may continue to be used by the... export) or importation of equipment employing digital modulation techniques in the 3700-4200, 5925-6425... equipment for operation in the 21,200-23,600 MHz band must meet: (1) The 0.001% frequency tolerance...

  4. Active/passive scanning. [airborne multispectral laser scanners for agricultural and water resources applications

    NASA Technical Reports Server (NTRS)

    Woodfill, J. R.; Thomson, F. J.

    1979-01-01

    The paper deals with the design, construction, and applications of an active/passive multispectral scanner combining lasers with conventional passive remote sensors. An application investigation was first undertaken to identify remote sensing applications where active/passive scanners (APS) would provide improvement over current means. Calibration techniques and instrument sensitivity are evaluated to provide predictions of the APS's capability to meet user needs. A preliminary instrument design was developed from the initial conceptual scheme. A design review settled the issues of worthwhile applications, calibration approach, hardware design, and laser complement. Next, a detailed mechanical design was drafted and construction of the APS commenced. The completed APS was tested and calibrated in the laboratory, then installed in a C-47 aircraft and ground tested. Several flight tests completed the test program.

  5. A Proxy Design to Leverage the Interconnection of CoAP Wireless Sensor Networks with Web Applications

    PubMed Central

    Ludovici, Alessandro; Calveras, Anna

    2015-01-01

    In this paper, we present the design of a Constrained Application Protocol (CoAP) proxy able to interconnect Web applications based on Hypertext Transfer Protocol (HTTP) and WebSocket with CoAP based Wireless Sensor Networks. Sensor networks are commonly used to monitor and control physical objects or environments. Smart Cities represent applications of such a nature. Wireless Sensor Networks gather data from their surroundings and send them to a remote application. This data flow may be short or long lived. The traditional HTTP long-polling used by Web applications may not be adequate in long-term communications. To overcome this problem, we include the WebSocket protocol in the design of the CoAP proxy. We evaluate the performance of the CoAP proxy in terms of latency and memory consumption. The tests consider long and short-lived communications. In both cases, we evaluate the performance obtained by the CoAP proxy according to the use of WebSocket and HTTP long-polling. PMID:25585107

  6. X-ray optics simulation and beamline design for the APS upgrade

    NASA Astrophysics Data System (ADS)

    Shi, Xianbo; Reininger, Ruben; Harder, Ross; Haeffner, Dean

    2017-08-01

    The upgrade of the Advanced Photon Source (APS) to a Multi-Bend Achromat (MBA) will increase the brightness of the APS by between two and three orders of magnitude. The APS upgrade (APS-U) project includes a list of feature beamlines that will take full advantage of the new machine. Many of the existing beamlines will be also upgraded to profit from this significant machine enhancement. Optics simulations are essential in the design and optimization of these new and existing beamlines. In this contribution, the simulation tools used and developed at APS, ranging from analytical to numerical methods, are summarized. Three general optical layouts are compared in terms of their coherence control and focusing capabilities. The concept of zoom optics, where two sets of focusing elements (e.g., CRLs and KB mirrors) are used to provide variable beam sizes at a fixed focal plane, is optimized analytically. The effects of figure errors on the vertical spot size and on the local coherence along the vertical direction of the optimized design are investigated.

  7. The health-related, social, and economic consequences of parkinsonism: a controlled national study.

    PubMed

    Jennum, Poul; Zoetmulder, Marielle; Korbo, Lise; Kjellberg, Jakob

    2011-08-01

    Parkinson's disease (PD) and atypical parkinsonism (AP) cause a significant socioeconomic burden, but there is insufficient information about the total disease burden at a national level. Thus, the goal of this study was to estimate the excess direct and indirect costs of PD and AP in a national sample. Using records from the Danish National Patient Registry (1997-2007), 13,400 PD and 647 AP patients were identified and compared with, respectively, 53,600 and 2,588 control cases randomly selected with respect to age, gender, civil status, and geographic location. Direct costs including frequencies of primary and sector contacts and procedures, and medication from primary and secondary sectors were obtained from the Danish Ministry of Health, the Danish Medicines Agency, and the National Health Security. Indirect costs, which included labor supply and social transfer payments, were based on income data derived from the Coherent Social Statistics. Patients with PD and AP had significantly higher rates of health-related contact and medication use and a higher socioeconomic cost. Furthermore, they had very low employment rates, and those in employment had a lower income level than employed control subjects. The annual mean excess health-related cost was 6,500 ($8,975/£5,543) and 9,771 ($13,491/£8,332) for each patient with PD and AP, respectively. In addition, the patients with PD and AP received an annual mean excess social transfer income of 324 (£276/$447) and 844 (£719/$1,165), respectively. The employment- and health-related consequences could be identified up to 8 years before the first diagnosis and increased with disease advancement. PD and AP have major socioeconomic consequences for patients and society. The health effects are present for up to more than 8 years before a diagnosis of PD/AP.

  8. VizieR Online Data Catalog: CANDELS z~2 galaxy properties (Trump+, 2014)

    NASA Astrophysics Data System (ADS)

    Trump, J. R.; Barro, G.; Juneau, S.; Weiner, B. J.; Luo, B.; Brammer, G. B.; Bell, E. F.; Brandt, W. N.; Dekel, A.; Guo, Y.; Hopkins, P. F.; Koo, D. C.; Kocevski, D. D.; McIntosh, D. H.; Momcheva, I.; Faber, S. M.; Ferguson, H. C.; Grogin, N. A.; Kartaltepe, J.; Koekemoer, A. M.; Lotz, J.; Maseda, M.; Mozena, M.; Nandra, K.; Rosario, D. J.; Zeimann, G. R.

    2017-04-01

    We select a sample of 44 clumpy galaxies from the Great Observatories Origins Deep Survey South (GOODS-S; Giavalisco et al. 2004ApJ...600L..93G) region of CANDELS. For comparison, we also construct mass-matched samples of 41 smooth (non-clumpy) and 35 intermediate galaxies. All galaxies have H<24 (to ensure reliable classification of clumpiness) and have [O III] detected at the 3σ level (for reliable AGN line ratio diagnostics) in the redshift range 1.3

  9. Telecommunication and Technology Infrastructure Program (TTIP) Certification for Expenditures, Fiscal Year 2000-2001.

    ERIC Educational Resources Information Center

    Williams, Lindy

    This document presents the guidelines for the California Community College 2000-2001 State-Funded Telecommunication and Technology Infrastructure Program (TTIP) Program. The 2000-2001 State Budget Act contains $44.3 million for expenditures on the TTIP. The Act provides that $31,600,000 be allocated to colleges for the following purposes: (1) data…

  10. 75 FR 1529 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, and -900 Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ...: No person may operate an aircraft for which a manufacturer's maintenance manual or instructions for..., or maintenance actions, which, in combination with flammable fuel vapors, could result in a fuel tank... Engineer, Propulsion Branch, ANM-140S, Seattle Aircraft Certification Office, FAA, 1601 Lind Avenue, SW...

  11. It's Not Easy Being Green: Green Marketing and Environmental Consumerism in Continuing Higher Education

    ERIC Educational Resources Information Center

    Sandeen, Cathy

    2009-01-01

    The current focus on all things "green--greener--greenest" has found its way into the realm of continuing higher education through a proliferation of courses and programs. A recent Internet search on the phrase "sustainability certificate" produced over 7,600 results, reflecting a strong perceived or real demand. In this…

  12. 76 FR 16579 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... Brakes FLIGHT DETENT. Target Speed VMO/MMO.'' (3) Revise the Normal Procedures Section of the applicable... Branch, ANM-130S, FAA, Seattle Aircraft Certification Office, 1601 Lind Avenue, SW., Renton, Washington... that section, Congress charges the FAA with promoting safe flight of civil aircraft in air commerce by...

  13. 40 CFR 600.514-12 - Reports to the Environmental Protection Agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... manufacturer shall submit a pre-model year report. (2) The pre-model year report required by this section for each model year must be submitted before the model year begins and before the certification of any test... pre-model year report for the 2012 model year must be submitted no later than December 31, 2010. (3...

  14. High-performance space shuttle auxiliary propellant valve system

    NASA Technical Reports Server (NTRS)

    Smith, G. M.

    1973-01-01

    Several potential valve closures for the space shuttle auxiliary propulsion system (SS/APS) were investigated analytically and experimentally in a modeling program. The most promising of these were analyzed and experimentally evaluated in a full-size functional valve test fixture of novel design. The engineering investigations conducted for both model and scale evaluations of the SS/APS valve closures and functional valve fixture are described. Preliminary designs, laboratory tests, and overall valve test fixture designs are presented, and a final recommended flightweight SS/APS valve design is presented.

  15. Design and implementation of PKI-based certification authority

    NASA Astrophysics Data System (ADS)

    Zheng, Ying; Bai, Qinghai; Zhao, Linna; Chun, Hua; Chen, Jing

    2015-12-01

    PKI achieves the management of public key by certificates. It combines the user's public key and his or her identification formation through a trusted third-party organization CA, in order to authenticate the user's identity on the Internet, thus ensuring the authenticity, integrity, confidentiality, and non- repudiation of the information transmitted on the Internet. CA is the most critical agency in the PKI system, mainly responsible for issuing and managing certificates. On the basis of the actual needs of an enterprise, in this paper the author designs and develops a small-sized PKI-based Certification Authority equipped with the functions of root CA initialization, certificate application, certificate issuance, certificate revocation, and the generation of certificate revocation list. The author also points out the problems that need to be mentioned in the design and development.

  16. APS deposition facility upgrades and future plans

    NASA Astrophysics Data System (ADS)

    Conley, Ray; Shi, Bing; Erdmann, Mark; Izzo, Scott; Assoufid, Lahsen; Goetze, Kurt; Mooney, Tim; Lauer, Kenneth

    2014-09-01

    The Advanced Photon Source (APS) has recently invested resources to upgrade or replace aging deposition systems with modern equipment. Of the three existing deposition systems, one will receive an upgrade, while two are being replaced. A design which adds a three-substrate planetary for the APS rotary deposition system is almost complete. The replacement for the APS large deposition system, dubbed the "Modular Deposition System", has been conceptually designed and is in the procurement process. Eight cathodes will sputter horizontally on mirrors up to 1.5 meters in length. This new instrument is designed to interface with ion-milling instruments and various metrology equipment for ion-beam figuring. A third linear machine, called the APS Profile Coating System, has two cathodes and is designed to accept substrates up to 200mm in length. While this machine is primarily intended for fabrication of figured KB mirrors using the profile-coating technique, it has also been used to produce multilayer monochromators for beamline use.

  17. Modeling Instruction in AP Physics C: Mechanics and Electricity and Magnetism

    NASA Astrophysics Data System (ADS)

    Belcher, Nathan Tillman

    This action research study used data from multiple assessments in Mechanics and Electricity and Magnetism to determine the viability of Modeling Instruction as a pedagogy for students in AP Physics C: Mechanics and Electricity and Magnetism. Modeling Instruction is a guided-inquiry approach to teaching science in which students progress through the Modeling Cycle to develop a fully-constructed model for a scientific concept. AP Physics C: Mechanics and Electricity and Magnetism are calculus-based physics courses, approximately equivalent to first-year calculus-based physics courses at the collegiate level. Using a one-group pretest-posttest design, students were assessed in Mechanics using the Force Concept Inventory, Mechanics Baseline Test, and 2015 AP Physics C: Mechanics Practice Exam. With the same design, students were assessed in Electricity and Magnetism on the Brief Electricity and Magnetism Assessment, Electricity and Magnetism Conceptual Assessment, and 2015 AP Physics C: Electricity and Magnetism Practice Exam. In a one-shot case study design, student scores were collected from the 2017 AP Physics C: Mechanics and Electricity and Magnetism Exams. Students performed moderately well on the assessments in Mechanics and Electricity and Magnetism, demonstrating that Modeling Instruction is a viable pedagogy in AP Physics C: Electricity and Magnetism.

  18. Human Systems Integration: Unmanned Aircraft Control Station Certification Plan Guidance

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This document provides guidance to the FAA on important human factors considerations that can be used to support the certification of a UAS Aircraft Control Station (ACS). This document provides a synopsis of the human factors analysis, design and test activities to be performed to provide a basis for FAA certification. The data from these analyses, design activities, and tests, along with data from certification/qualification tests of other key components should be used to establish the ACS certification basis. It is expected that this information will be useful to manufacturers in developing the ACS Certification Plan,, and in supporting the design of their ACS.

  19. Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes.

    PubMed

    Bartos, Daniel C; Morotti, Stefano; Ginsburg, Kenneth S; Grandi, Eleonora; Bers, Donald M

    2017-04-01

    [Ca 2+ ] i enhanced rabbit ventricular slowly activating delayed rectifier K + current (I Ks ) by negatively shifting the voltage dependence of activation and slowing deactivation, similar to perfusion of isoproterenol. Rabbit ventricular rapidly activating delayed rectifier K + current (I Kr ) amplitude and voltage dependence were unaffected by high [Ca 2+ ] i . When measuring or simulating I Ks during an action potential, I Ks was not different during a physiological Ca 2+ transient or when [Ca 2+ ] i was buffered to 500 nm. The slowly activating delayed rectifier K + current (I Ks ) contributes to repolarization of the cardiac action potential (AP). Intracellular Ca 2+ ([Ca 2+ ] i ) and β-adrenergic receptor (β-AR) stimulation modulate I Ks amplitude and kinetics, but details of these important I Ks regulators and their interaction are limited. We assessed the [Ca 2+ ] i dependence of I Ks in steady-state conditions and with dynamically changing membrane potential and [Ca 2+ ] i during an AP. I Ks was recorded from freshly isolated rabbit ventricular myocytes using whole-cell patch clamp. With intracellular pipette solutions that controlled free [Ca 2+ ] i , we found that raising [Ca 2+ ] i from 100 to 600 nm produced similar increases in I Ks as did β-AR activation, and the effects appeared additive. Both β-AR activation and high [Ca 2+ ] i increased maximally activated tail I Ks , negatively shifted the voltage dependence of activation, and slowed deactivation kinetics. These data informed changes in our well-established mathematical model of the rabbit myocyte. In both AP-clamp experiments and simulations, I Ks recorded during a normal physiological Ca 2+ transient was similar to I Ks measured with [Ca 2+ ] i clamped at 500-600 nm. Thus, our study provides novel quantitative data as to how physiological [Ca 2+ ] i regulates I Ks amplitude and kinetics during the normal rabbit AP. Our results suggest that micromolar [Ca 2+ ] i , in the submembrane or junctional cleft space, is not required to maximize [Ca 2+ ] i -dependent I Ks activation during normal Ca 2+ transients. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

  20. 47 CFR 68.160 - Designation of Telecommunication Certification Bodies (TCBs).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Designation of Telecommunication Certification Bodies (TCBs). 68.160 Section 68.160 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... on Use of Terminal Equipment § 68.160 Designation of Telecommunication Certification Bodies (TCBs...

  1. 47 CFR 68.160 - Designation of Telecommunication Certification Bodies (TCBs).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Designation of Telecommunication Certification Bodies (TCBs). 68.160 Section 68.160 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... on Use of Terminal Equipment § 68.160 Designation of Telecommunication Certification Bodies (TCBs...

  2. Engineering-Based Problem Solving Strategies in AP Calculus: An Investigation into High School Student Performance on Related Rate Free-Response Problems

    ERIC Educational Resources Information Center

    Thieken, John

    2012-01-01

    A sample of 127 high school Advanced Placement (AP) Calculus students from two schools was utilized to study the effects of an engineering design-based problem solving strategy on student performance with AP style Related Rate questions and changes in conceptions, beliefs, and influences. The research design followed a treatment-control multiple…

  3. Contrasting styles of Mount Vesuvius activity in the period between the Avellino and Pompeii Plinian eruptions, and some implications for assessment of future hazards

    NASA Astrophysics Data System (ADS)

    Andronico, Daniele; Cioni, Raffaello

    2002-09-01

    Intense explosive activity occurred repeatedly at Vesuvius during the nearly 1,600-year period between the two Plinian eruptions of Avellino (3.5 ka) and Pompeii (79 A.D.). By correlating stratigraphic sections from more than 40 sites around the volcano, we identify the deposits of six main eruptions (AP1-AP6) and of some minor intervening events. Several deposits can be traced up to 20 km from the vent. Their stratigraphic and dispersal features suggest the prevalence of two main contrasting eruptive styles, each involving a complex relationship between magmatic and phreatomagmatic phases. The two main eruption styles are (1) sub-Plinian to phreato-Plinian events (AP1 and AP2 members), where deposits consist of pumice and scoria fall layers alternating with fine-grained, vesiculated, accretionary lapilli-bearing ashes; and (2) mixed, violent Strombolian to Vulcanian events (AP3-AP6 members), which deposited a complex sequence of fallout, massive to thinly stratified, scoria-bearing lapilli layers and fine ash beds. Morphology and density variations of the juvenile fragments confirm the important role played by magma-water interaction in the eruptive dynamics. The mean composition of the ejected material changes with time, and shows a strong correlation with vent position and eruption style. The ranges of intensity and magnitude of these events, derived by estimations of peak column height and volume of the ejecta, are significantly smaller than the values for the better known Plinian and sub-Plinian eruptions of Vesuvius, enlarging the spectrum of the possible eruptive scenarios at Vesuvius, useful in the assessment of its potential hazard.

  4. A second-generation superconducting undulator cryostat for the APS

    NASA Astrophysics Data System (ADS)

    Fuerst, J.; Hasse, Q.; Ivanyushenkov, Y.; Kasa, M.; Shiroyanagi, Y.

    2017-12-01

    A second-generation cryocooler-based cryostat has been designed and built to support a new helically wound superconducting undulator (SCU) magnet for the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). The design represents an evolution of existing SCU cryostats currently in operation in the APS storage ring. Value engineering and lessons learned have resulted in a smaller, cheaper, and simpler cryostat design compatible with existing planar magnets as well as the new helically wound device. We describe heat load and quench response results, design and operational details, and the “build-to-spec” procurement strategy.

  5. 78 FR 59981 - Proposed Revision to Physical Security-Standard Design Certification and Operating Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-30

    ... the Standard Review Plan (SRP), concerning the physical security reviews of design certification... NRC staff with the physical security review of applications for design certifications, incorporate... NUCLEAR REGULATORY COMMISSION [NRC-2013-0225] Proposed Revision to Physical Security--Standard...

  6. AP1000{sup R} design robustness against extreme external events - Seismic, flooding, and aircraft crash

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pfister, A.; Goossen, C.; Coogler, K.

    2012-07-01

    Both the International Atomic Energy Agency (IAEA) and the U.S. Nuclear Regulatory Commission (NRC) require existing and new nuclear power plants to conduct plant assessments to demonstrate the unit's ability to withstand external hazards. The events that occurred at the Fukushima-Dai-ichi nuclear power station demonstrated the importance of designing a nuclear power plant with the ability to protect the plant against extreme external hazards. The innovative design of the AP1000{sup R} nuclear power plant provides unparalleled protection against catastrophic external events which can lead to extensive infrastructure damage and place the plant in an extended abnormal situation. The AP1000 plantmore » is an 1100-MWe pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance and safety. The plant's compact safety related footprint and protection provided by its robust nuclear island structures prevent significant damage to systems, structures, and components required to safely shutdown the plant and maintain core and spent fuel pool cooling and containment integrity following extreme external events. The AP1000 nuclear power plant has been extensively analyzed and reviewed to demonstrate that it's nuclear island design and plant layout provide protection against both design basis and extreme beyond design basis external hazards such as extreme seismic events, external flooding that exceeds the maximum probable flood limit, and malicious aircraft impact. The AP1000 nuclear power plant uses fail safe passive features to mitigate design basis accidents. The passive safety systems are designed to function without safety-grade support systems (such as AC power, component cooling water, service water, compressed air or HVAC). The plant has been designed to protect systems, structures, and components critical to placing the reactor in a safe shutdown condition within the steel containment vessel which is further surrounded by a substantial 'steel concrete' composite shield building. The containment vessel is not affected by external flooding, and the shield building design provides hazard protection beyond that provided by a comparable reinforced concrete structure. The intent of this paper is to demonstrate the robustness of the AP1000 design against extreme events. The paper will focus on the plants ability to withstand extreme external events such as beyond design basis flooding, seismic events, and malicious aircraft impact. The paper will highlight the robustness of the AP1000 nuclear island design including the protection provided by the unique AP1000 composite shield building. (authors)« less

  7. 14 CFR 21.99 - Required design changes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.99 Required design changes. (a) When an Airworthiness Directive is issued under Part 39 the holder of the type certificate for the... approval of the design changes, make available the descriptive data covering the changes to all operators...

  8. 14 CFR 21.99 - Required design changes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.99 Required design changes. (a) When an Airworthiness Directive is issued under Part 39 the holder of the type certificate for the... approval of the design changes, make available the descriptive data covering the changes to all operators...

  9. 14 CFR 21.99 - Required design changes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.99 Required design changes. (a) When an Airworthiness Directive is issued under Part 39 the holder of the type certificate for the... approval of the design changes, make available the descriptive data covering the changes to all operators...

  10. 14 CFR 21.99 - Required design changes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.99 Required design changes. (a) When an Airworthiness Directive is issued under Part 39 the holder of the type certificate for the...; and (2) Upon approval of the design changes, make available the descriptive data covering the changes...

  11. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  12. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  13. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  14. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  15. 7 CFR 868.262 - Grade designation and other certificate information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Brown Rice for Processing Principles Governing Application of Standards § 868.262 Grade designation and other certificate information. (a) Brown rice for processing. The grade designation for all classes of Brown rice for processing shall be included on the certificate grade-line in the following order: (1...

  16. IMCS reflight certification requirements and design specifications

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The requirements for reflight certification are established. Software requirements encompass the software programs that are resident in the PCC, DEP, PDSS, EC, or any related GSE. A design approach for the reflight software packages is recommended. These designs will be of sufficient detail to permit the implementation of reflight software. The PDSS/IMC Reflight Certification system provides the tools and mechanisms for the user to perform the reflight certification test procedures, test data capture, test data display, and test data analysis. The system as defined will be structured to permit maximum automation of reflight certification procedures and test data analysis.

  17. Army and Marine Corps Active Protection System (APS) Efforts

    DTIC Science & Technology

    2016-08-30

    efforts—the Expedited, Non-Developmental Item (NDI) APS effort and the Modular Active Protection System (MAPS) effort. The Marines describe their...17 Modular Active Protection System (MAPS) Effort .......................................................... 18 The Marine Corps APS...Merkava Mark 4 tank was designed around the Trophy APS. 32 The Army’s Modular Active Protection System (MAPS) effort, described below, is intended to

  18. APS-U LATTICE DESIGN FOR OFF-AXIS ACCUMULATION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sun, Yipeng; Borland, M.; Lindberg, R.

    2017-06-25

    A 67-pm hybrid-seven-bend achromat (H7BA) lattice is being proposed for a future Advanced Photon Source (APS) multi-bend-achromat (MBA) upgrade project. This lattice design pushes for smaller emittance and requires use of a swap-out (on-axis) injection scheme due to limited dynamic acceptance. Alternate lattice design work has also been performed for the APS upgrade to achieve better beam dynamics performance than the nominal APS MBA lattice, in order to allow off-axis accumulation. Two such alternate H7BA lattice designs, which target a still-low emittance of 90 pm, are discussed in detail in this paper. Although the single-particle-dynamics performance is good, simulations ofmore » collective effects indicate that surprising difficulty would be expected accumulating high single-bunch charge in this lattice. The brightness of the 90-pm lattice is also a factor of two lower than the 67-pm H7BA lattice.« less

  19. AP1000{sup R} severe accident features and post-Fukushima considerations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scobel, J. H.; Schulz, T. L.; Williams, M. G.

    2012-07-01

    The AP1000{sup R} passive nuclear power plant is uniquely equipped to withstand an extended station blackout scenario such as the events following the earthquake and tsunami at Fukushima without compromising core and containment integrity. The AP1000 plant shuts down the reactor, cools the core, containment and spent fuel pool for more than 3 days using passive systems that do not require AC or DC power or operator actions. Following this passive coping period, minimal operator actions are needed to extend the operation of the passive features to 7 days using installed equipment. To provide defense-in-depth for design extension conditions, themore » AP1000 plant has engineered features that mitigate the effects of core damage. Engineered features retain damaged core debris within the reactor vessel as a key feature. Other aspects of the design protect containment integrity during severe accidents, including unique features of the AP1000 design relative to passive containment cooling with water and air, and hydrogen management. (authors)« less

  20. Anteroposterior translation and range of motion after total knee arthroplasty using posterior cruciate ligament-retaining versus posterior cruciate ligament-substituting prostheses.

    PubMed

    Ishii, Yoshinori; Noguchi, Hideo; Sato, Junko; Sakurai, Tetsuya; Toyabe, Shin-Ichi

    2017-11-01

    It is still controversial whether anteroposterior (AP) translation magnitude after total knee arthroplasty (TKA) affects clinical outcomes, particularly range of motion (ROM). This study examined the following two questions: (1) are AP translations at the mid- and long-term follow-up different for knees within the same patient treated with posterior cruciate ligament-retaining (PCLR) versus posterior cruciate ligament-substituting (PCLS) mobile-bearing TKA prosthesis designs? (2) Is the ROM at the mid- and long-term follow-up for knees treated with PCLR and PCLS designs correlated with the AP translation? Thirty-seven patients undergoing sequential bilateral TKA for osteoarthritis were prospectively enrolled. Patients received a PCLR implant in one knee and a PCLS implant in the other and were followed-up for an average 9.8 ± 3.2 years. The AP translations at 30° and 75° of knee flexion and the ROM of both knees were assessed. The implant design (p < 0.001), but not flexion angle (n.s.), had a significant effect on AP translation. AP translation values were larger in PCLR knees than in PCLS knees at both flexion angles (p < 0.0001). The ROM at the final follow-up in the two implant designs was similar (both 115°, n.s.). There was a weak correlation between ROM and AP translation at 30° in the PCLR knees (r = 0.397, p = 0.015), but no correlation at 75° or in the PCLS knees. Differently constrained prosthesis designs resulted in significantly different AP translational values within the same patient. This indicates that achieving good clinical outcomes and ROM after TKA may not be strongly influenced by the specifics of each patient's anatomical characteristics, but instead by knee constrainment. Clinically, this means that surgeons should familiarize themselves with the AP translation of the implant being used, as this may be the most important factor for optimizing outcomes after mobile-bearing TKA. Level of evidence II, prospective, comparative study.

  1. 75 FR 3127 - Airworthiness Directives; Thrush Aircraft, Inc. Model 600 S2D and S2R Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... airplanes (type certificate previously held by Quality Aerospace, Inc. and Ayres Corporation). AD 2006-07-15... of AD 2006-07-15 and imposes a life limit on the wing front lower spar caps that requires replacement of the wing front lower spar caps when the life limit is reached. This AD also changes the...

  2. 14 CFR 21.191 - Experimental certificates.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... Experimental certificates are issued for the following purposes: (a) Research and development. Testing new aircraft design concepts, new aircraft equipment, new aircraft installations, new aircraft operating... compliance for issuance of type and supplemental type certificates, flights to substantiate major design...

  3. 14 CFR 21.191 - Experimental certificates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Experimental certificates are issued for the following purposes: (a) Research and development. Testing new aircraft design concepts, new aircraft equipment, new aircraft installations, new aircraft operating... compliance for issuance of type and supplemental type certificates, flights to substantiate major design...

  4. 14 CFR 21.191 - Experimental certificates.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... Experimental certificates are issued for the following purposes: (a) Research and development. Testing new aircraft design concepts, new aircraft equipment, new aircraft installations, new aircraft operating... compliance for issuance of type and supplemental type certificates, flights to substantiate major design...

  5. 14 CFR 21.191 - Experimental certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Experimental certificates are issued for the following purposes: (a) Research and development. Testing new aircraft design concepts, new aircraft equipment, new aircraft installations, new aircraft operating... compliance for issuance of type and supplemental type certificates, flights to substantiate major design...

  6. 50 CFR 622.41 - Species specific limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-certification. The pre-certification phase allows a person to test and evaluate a new BRD design for up to 60... authorized by the RA to participate in the pre-certification testing phase or to test a BRD in the EEZ for...-certification phase allows a person to test and evaluate a new BRD design for up to 60 days without being...

  7. 50 CFR 622.41 - Species specific limitations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-certification. The pre-certification phase allows a person to test and evaluate a new BRD design for up to 60... authorized by the RA to participate in the pre-certification testing phase or to test a BRD in the EEZ for...-certification phase allows a person to test and evaluate a new BRD design for up to 60 days without being...

  8. Adjustable Parameter-Based Distributed Fault Estimation Observer Design for Multiagent Systems With Directed Graphs.

    PubMed

    Zhang, Ke; Jiang, Bin; Shi, Peng

    2017-02-01

    In this paper, a novel adjustable parameter (AP)-based distributed fault estimation observer (DFEO) is proposed for multiagent systems (MASs) with the directed communication topology. First, a relative output estimation error is defined based on the communication topology of MASs. Then a DFEO with AP is constructed with the purpose of improving the accuracy of fault estimation. Based on H ∞ and H 2 with pole placement, multiconstrained design is given to calculate the gain of DFEO. Finally, simulation results are presented to illustrate the feasibility and effectiveness of the proposed DFEO design with AP.

  9. An Investigation of Experimental Techniques for Obtaining Particulate Behavior in Metallized Solid Propellant Combustion.

    DTIC Science & Technology

    1984-02-01

    Additive Particle Size Propellant Binder Oxidizer Metal Mean Metal Diameter, Designation % Weight % Weight* % Weight Microns WGS-5A HTPB 12 AP 83 AL 5 75...88 4 WGS-6A HTPB 12 AP 83 AL 5 45-62 WGS-7A HTPB 12 AP 83 AL 5 23-37 WGS-7 HTPB 12 AP 83 AL 5 6-7 WGS-9 HTPB 12 AP 78 AL 10 23-27 WGS-1O HTPB 12 AP 73...AL 15 23-27 WGS-ZrC HTPB 14 AP 84 ZrC 2 23, irregularly shaped WGS-G HTPB 14 AP 84 G 2 50x20x7, flakes * 65% 180 jim/35% 26 tim These propellants

  10. Thermal properties of Bentonite Modified with 3-aminopropyltrimethoxysilane

    NASA Astrophysics Data System (ADS)

    Pramono, E.; Pratiwi, W.; Wahyuningrum, D.; Radiman, C. L.

    2018-03-01

    Chemical modifications of Bentonite (BNT) clay have been carried out by using 3-aminoprophyltrimethoxysilane (APS) in various solvent media. The degradation properties of products (BNTAPS) were characterized by thermogravimetric analysis (TGA). Samples were heated at 30 to 700°C with a heating rate 10 deg/min, and the total silane-grafted amount was determined by calculating the weight loss at 200 – 600°C. The thermogram of TGA showed that there were three main decomposition regions which are attributed to the elimination of physically adsorbed water, decomposition of silane and dehydroxylation of Bentonite. High weight loss attributed to the thermal decomposition of silane was observed between 200 to 550°C. Quantitative analysis of grafted silane results high silane loaded using a solvent with high surface energy, which indicates the type of solvent affected interaction and adsorption of APS in BNT platelets.

  11. VizieR Online Data Catalog: Binary white dwarfs atmospheric parameters (Gianninas+, 2014)

    NASA Astrophysics Data System (ADS)

    Gianninas, A.; Dufour, P.; Kilic, M.; Brown, W. R.; Bergeron, P.; Hermes, J. J.

    2017-04-01

    The sample that we analyze includes a total of 61 ELM WD binaries from the ELM Survey (Brown et al. 2013, J/ApJ/769/66). The bulk of this sample is comprised of the 58 ELM WDs listed in Table 3 of Brown et al. (2013, J/ApJ/769/66), but also includes three additional ELM WDs that have been published in separate papers since then. The spectra of these 61 ELM WDs were obtained using five distinct setups on two different telescopes. A total of 57 targets were observed with the 6.5m MMT telescope with the Blue Channel spectrograph (Schmidt et al. 1989PASP..101..713S). The four remaining targets were observed using the Fred Lawrence Whipple Observatory's (FLWO) 1.5m Tilinghast telescope equipped with the FAST spectrograph (Fabricant et al. 1998PASP..110...79F) and the 600 line/mm grating. (2 data files).

  12. 14 CFR 21.41 - Type certificate.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Type certificate. 21.41 Section 21.41...

  13. 14 CFR 21.41 - Type certificate.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Type certificate. 21.41 Section 21.41...

  14. 14 CFR 21.41 - Type certificate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Type certificate. 21.41 Section 21.41...

  15. 14 CFR 21.41 - Type certificate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Type certificate. 21.41 Section 21.41...

  16. 14 CFR 21.41 - Type certificate.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.41 Type certificate. Each type certificate is considered to include the type design, the operating limitations, the certificate data sheet, the applicable... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Type certificate. 21.41 Section 21.41...

  17. The Nuclear Renaissance — Implications on Quantitative Nondestructive Evaluations

    NASA Astrophysics Data System (ADS)

    Matzie, Regis A.

    2007-03-01

    The world demand for energy is growing rapidly, particularly in developing countries that are trying to raise the standard of living for billions of people, many of whom do not even have access to electricity. With this increased energy demand and the high and volatile price of fossil fuels, nuclear energy is experiencing resurgence. This so-called nuclear renaissance is broad based, reaching across Asia, the United States, Europe, as well as selected countries in Africa and South America. Some countries, such as Italy, that have actually turned away from nuclear energy are reconsidering the advisability of this design. This renaissance provides the opportunity to deploy more advanced reactor designs that are operating today, with improved safety, economy, and operations. In this keynote address, I will briefly present three such advanced reactor designs in whose development Westinghouse is participating. These designs include the advanced passive PWR, AP1000, which recently received design certification for the US Nuclear Regulatory Commission; the Pebble Bed Modular reactor (PBMR) which is being demonstrated in South Africa; and the International Reactor Innovative and Secure (IRIS), which was showcased in the US Department of Energy's recently announced Global Nuclear Energy Partnership (GNEP), program. The salient features of these designs that impact future requirements on quantitative nondestructive evaluations will be discussed. Such features as reactor vessel materials, operating temperature regimes, and new geometric configurations will be described, and mention will be made of the impact on quantitative nondestructive evaluation (NDE) approaches.

  18. 50 CFR 600.1417 - Requirements for exempted state designation based on submission of recreational survey data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the state's participation in a qualifying regional survey, and the survey's sample design, data... designation based on submission of recreational survey data. 600.1417 Section 600.1417 Wildlife and Fisheries... Requirements for exempted state designation based on submission of recreational survey data. (a) To be...

  19. 50 CFR 600.1417 - Requirements for exempted state designation based on submission of recreational survey data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the state's participation in a qualifying regional survey, and the survey's sample design, data... designation based on submission of recreational survey data. 600.1417 Section 600.1417 Wildlife and Fisheries... Requirements for exempted state designation based on submission of recreational survey data. (a) To be...

  20. CSWP Networking Reception

    NASA Astrophysics Data System (ADS)

    Unwind after a long day of sessions by networking with women physicists from the APS Committee on the Status of Women in Physics and members of the APS Panel on Public Affairs (POPA). Cocktails and conversation will flow as we learn about the recently approved APS Statement on the Status of Women in Physics; a POPA study underway, designed to evaluate what top universities are doing to address gender disparity in undergraduate physics programs; and initiatives & programs designed to attract, retain, develop, and support the female physicists in our community.

  1. Certify for success: A methodology for human-centered certification of advanced aviation systems

    NASA Technical Reports Server (NTRS)

    Small, Ronald L.; Rouse, William B.

    1994-01-01

    This position paper uses the methodology in Design for Success as a basis for a human factors certification program. The Design for Success (DFS) methodology espouses a multi-step process to designing and developing systems in a human-centered fashion. These steps are as follows: (1) naturalizing - understand stakeholders and their concerns; (2) marketing - understand market-oriented alternatives to meeting stakeholder concerns; (3) engineering - detailed design and development of the system considering tradeoffs between technology, cost, schedule, certification requirements, etc.; (4) system evaluation - determining if the system meets its goal(s); and (5) sales and service - delivering and maintaining the system. Because the main topic of this paper is certification, we will focus our attention on step 4, System Evaluation, since it is the natural precursor to certification. Evaluation involves testing the system and its parts for their correct behaviors. Certification focuses not only on ensuring that the system exhibits the correct behaviors, but ONLY the correct behaviors.

  2. Project W-211, initial tank retrieval systems, description of operations for 241-AP-102 and 241-AP-104

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    RIECK, C.A.

    1999-02-25

    The primary purpose of the Initial Tank Retrieval Systems (ITRS) is to provide systems for retrieval of radioactive wastes stored in underground double-shell tanks (DSTS) for transfer to alternate storage, evaporation, pretreatment or treatment, while concurrently reducing risks associated with safety watch list and other DSTs. This Description of Operations (DOO) defines the control philosophy for the waste retrieval system for tanks 241-AP-102 (AP-102) and 241-AP-104 (AP-104). This DOO will provide a basis for the detailed design of the Retrieval Control System (RCS) for AP-102 and AP-104 and establishes test criteria for the RCS. The test criteria will be usedmore » during qualification testing and acceptance testing to verify operability.« less

  3. The pursuit of Leadership in Energy and Environmental Design (LEED) certification for campus housing at public universities

    NASA Astrophysics Data System (ADS)

    Konvalinka, April Hicks

    This dissertation identifies the reasons why institutions of higher education pursue Leadership in Energy and Environmental Design (LEED) certification for new construction of campus housing. The research was guided by three questions: 1. Why did the institution choose to pursue LEED certification for campus housing? 2. What considerations should be made in the design, development, and planning process of a LEED residence hall? 3. What significant impact has the LEED residence hall made on campus? The outcomes of this study will provide insight to university and housing administrators who are considering pursuit of LEED certification for new residence hall development. The primary sources of data are chief housing officers or their designees at public four-year colleges and universities with new campus housing awarded LEED certification. Qualitative research techniques were used to conduct interviews by LEED certification level: Platinum, Silver, Gold, and Certified. Data collection ended when data saturation of each question in each certification level was achieved. This dissertation offers reasons why universities pursue LEED certification: state requirement, institutional commitment, institutional standard, environmental stewardship, departmental decision, and student interest. Additionally, considerations and lessons learned from the pursuit of LEED certification have been identified and can serve as a guide to housing administrators who aim to achieve any LEED level certification.

  4. November 2013 Analysis of High Energy Electrons on the Japan Experimental Module (JEM: Kibo)

    NASA Technical Reports Server (NTRS)

    Badavi, Francis F.; Matsumoto, Haruhisa; Koga, Kiyokazu; Mertens, Christopher J.; Slaba, Tony C.; Norbury, John W.

    2015-01-01

    Albedo (precipitating/splash) electrons, created by galactic cosmic rays (GCR) interaction with the upper atmosphere move upwards away from the surface of the earth. In the past validation work these particles were often considered to have negligible contribution to astronaut radiation exposure on the International Space Station (ISS). Estimates of astronaut exposure based on the available Computer Aided Design (CAD) models of ISS consistently underestimated measurements onboard ISS when the contribution of albedo particles to exposure were neglected. Recent measurements of high energy electrons outside ISS Japan Experimental Module (JEM) using Exposed Facility (EF), Space Environment Data Acquisition Equipment - Attached Payload (SEDA-AP) and Standard DOse Monitor (SDOM), indicates the presence of high energy electrons at ISS altitude. In this presentation the status of these energetic electrons is reviewed and mechanism for the creation of these particles inside/outside South Atlantic Anomaly (SAA) region explained. In addition, limited dosimetric evaluation of these electrons at 600 MeV and 10 GeV is presented.

  5. 10 CFR 52.61 - Duration of renewal.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Duration of renewal. 52.61 Section 52.61 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Standard Design Certifications § 52.61 Duration of renewal. Each renewal of certification for a standard design...

  6. 50 CFR 600.1417 - Requirements for exempted state designation based on submission of recreational survey data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the state's participation in a qualifying regional survey, and the survey's sample design, data...) Meet NMFS survey design and data collection standards. [73 FR 79717, Dec. 30, 2008, as amended at 77 FR... designation based on submission of recreational survey data. 600.1417 Section 600.1417 Wildlife and Fisheries...

  7. 50 CFR 600.1417 - Requirements for exempted state designation based on submission of recreational survey data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the state's participation in a qualifying regional survey, and the survey's sample design, data...) Meet NMFS survey design and data collection standards. [73 FR 79717, Dec. 30, 2008, as amended at 77 FR... designation based on submission of recreational survey data. 600.1417 Section 600.1417 Wildlife and Fisheries...

  8. 50 CFR 600.1417 - Requirements for exempted state designation based on submission of recreational survey data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the state's participation in a qualifying regional survey, and the survey's sample design, data...) Meet NMFS survey design and data collection standards. [73 FR 79717, Dec. 30, 2008, as amended at 77 FR... designation based on submission of recreational survey data. 600.1417 Section 600.1417 Wildlife and Fisheries...

  9. 21 CFR 1314.102 - Self-certification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...-certification for all regulated persons in any group will be the last day of the month designated for that group... the initial certification period, the regulated person must update the self-certification annually. (c...

  10. 21 CFR 1314.102 - Self-certification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...-certification for all regulated persons in any group will be the last day of the month designated for that group... the initial certification period, the regulated person must update the self-certification annually. (c...

  11. 21 CFR 1314.102 - Self-certification.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...-certification for all regulated persons in any group will be the last day of the month designated for that group... the initial certification period, the regulated person must update the self-certification annually. (c...

  12. AP1000{sup R} nuclear power plant safety overview for spent fuel cooling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gorgemans, J.; Mulhollem, L.; Glavin, J.

    2012-07-01

    The AP1000{sup R} plant is an 1100-MWe class pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance, safety and costs. The AP1000 design uses passive features to mitigate design basis accidents. The passive safety systems are designed to function without safety-grade support systems such as AC power, component cooling water, service water or HVAC. Furthermore, these passive features 'fail safe' during a non-LOCA event such that DC power and instrumentation are not required. The AP1000 also has simple, active, defense-in-depth systems to support normal plant operations. These active systems provide the first levelmore » of defense against more probable events and they provide investment protection, reduce the demands on the passive features and support the probabilistic risk assessment. The AP1000 passive safety approach allows the plant to achieve and maintain safe shutdown in case of an accident for 72 hours without operator action, meeting the expectations provided in the U.S. Utility Requirement Document and the European Utility Requirements for passive plants. Limited operator actions are required to maintain safe conditions in the spent fuel pool via passive means. In line with the AP1000 approach to safety described above, the AP1000 plant design features multiple, diverse lines of defense to ensure spent fuel cooling can be maintained for design-basis events and beyond design-basis accidents. During normal and abnormal conditions, defense-in-depth and other systems provide highly reliable spent fuel pool cooling. They rely on off-site AC power or the on-site standby diesel generators. For unlikely design basis events with an extended loss of AC power (i.e., station blackout) or loss of heat sink or both, spent fuel cooling can still be provided indefinitely: - Passive systems, requiring minimal or no operator actions, are sufficient for at least 72 hours under all possible pool heat load conditions. - After 3 days, several different means are provided to continue spent fuel cooling using installed plant equipment as well as off-site equipment with built-in connections. Even for beyond design basis accidents with postulated pool damage and multiple failures in the passive safety-related systems and in the defense-in-depth active systems, the AP1000 multiple spent fuel pool spray and fill systems provide additional lines of defense to prevent spent fuel damage. (authors)« less

  13. 77 FR 74852 - Draft Guidance for Industry on Certification of Designated Medical Gases; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ... the availability of a draft guidance for industry entitled ``Certification Process for Designated Medical Gases.'' This draft guidance describes the new certification process created by the Food and Drug Administration Safety and Innovation Act (FDASIA) for certain medical gases and explains how FDA plans to...

  14. 26 CFR 1.43-3 - Certification

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... certification to the Internal Revenue Service Center, Austin, Texas, or such other place as may be designated by... must submit an operator's certification to the Internal Revenue Service Center, Austin, Texas, or such... Center, Austin, Texas, or such other place as may be designated by revenue procedure or other published...

  15. 26 CFR 1.43-3 - Certification

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... certification to the Internal Revenue Service Center, Austin, Texas, or such other place as may be designated by... must submit an operator's certification to the Internal Revenue Service Center, Austin, Texas, or such... Center, Austin, Texas, or such other place as may be designated by revenue procedure or other published...

  16. 26 CFR 1.43-3 - Certification

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... certification to the Internal Revenue Service Center, Austin, Texas, or such other place as may be designated by... must submit an operator's certification to the Internal Revenue Service Center, Austin, Texas, or such... Center, Austin, Texas, or such other place as may be designated by revenue procedure or other published...

  17. 26 CFR 1.43-3 - Certification

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... certification to the Internal Revenue Service Center, Austin, Texas, or such other place as may be designated by... must submit an operator's certification to the Internal Revenue Service Center, Austin, Texas, or such... Center, Austin, Texas, or such other place as may be designated by revenue procedure or other published...

  18. 45 CFR 170.304 - Specific certification criteria for Complete EHRs or EHR Modules designed for an ambulatory setting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.304 Specific certification criteria...

  19. 45 CFR 170.306 - Specific certification criteria for Complete EHRs or EHR Modules designed for an inpatient setting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.306 Specific certification criteria...

  20. 45 CFR 170.306 - Specific certification criteria for Complete EHRs or EHR Modules designed for an inpatient setting.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.306 Specific certification criteria...

  1. 45 CFR 170.304 - Specific certification criteria for Complete EHRs or EHR Modules designed for an ambulatory setting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of Health and Human Services HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.304 Specific certification criteria...

  2. 45 CFR 170.306 - Specific certification criteria for Complete EHRs or EHR Modules designed for an inpatient setting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.306 Specific certification criteria...

  3. 45 CFR 170.304 - Specific certification criteria for Complete EHRs or EHR Modules designed for an ambulatory setting.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.304 Specific certification criteria...

  4. 45 CFR 170.304 - Specific certification criteria for Complete EHRs or EHR Modules designed for an ambulatory setting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.304 Specific certification criteria...

  5. 45 CFR 170.304 - Specific certification criteria for Complete EHRs or EHR Modules designed for an ambulatory setting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.304 Specific certification criteria...

  6. 45 CFR 170.306 - Specific certification criteria for Complete EHRs or EHR Modules designed for an inpatient setting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of Health and Human Services HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.306 Specific certification criteria...

  7. 45 CFR 170.306 - Specific certification criteria for Complete EHRs or EHR Modules designed for an inpatient setting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Certification Criteria for Health Information Technology § 170.306 Specific certification criteria...

  8. Implementation and Initial Validation of the APS English Test [and] The APS English-Writing Test at Golden West College: Evidence for Predictive Validity.

    ERIC Educational Resources Information Center

    Isonio, Steven

    In May 1991, Golden West College (California) conducted a validation study of the English portion of the Assessment and Placement Services for Community Colleges (APS), followed by a predictive validity study in July 1991. The initial study was designed to aid in the implementation of the new test at GWC by comparing data on APS use at other…

  9. NFκB- and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcription in TNF-α-treated human leukemia U937 cells.

    PubMed

    Chen, Ying-Jung; Chang, Long-Sen

    2015-10-01

    The aim of this study is to explore the spatial association of critical genomic elements in the effect of TNF-α on matrix metalloproteinase-9 (MMP-9) expression in human leukemia U937 cells. TNF-α up-regulated MMP-9 protein expression and mRNA level in U937 cells, and Akt-mediated-NFκB/p65 activation and JNK-mediated c-Jun activation were proven to be involved in TNF-α-induced MMP-9 up-regulation. Promoter luciferase activity assay revealed that NFκB (nt-600) and AP-1 (nt-79) binding sites were crucial for TNF-α-induced transcription of MMP-9 gene. The results of a chromatin immunoprecipitation assay indicated that TNF-α reduced histone deacetylase-1 (HDAC-1) recruitment but increased p300 (a histone acetyltransferase) recruitment to MMP-9 promoter regions surrounding NFκB and AP-1 binding sites. Consistently, TNF-α increased enrichment of the acetylated histone H3 mark on MMP-9 promoter regions. DNA affinity purification assay revealed that p300 and HDAC1 could bind oligonucleotides containing AP-1/c-Jun and NFκB/p65 binding sites. Chromosome conformation capture assay showed that TNF-α stimulated chromosomal loops in the MMP-9 promoter via NFκB/p65 and AP-1/c-Jun. The p300-associated acetyltransferase activity was crucial for p65/c-Jun-mediated DNA looping, and inhibition of HDAC activity increased the level of DNA looping. Reduction in the level of DNA looping eliminated all TNF-α-stimulated MMP-9 up-regulation. Taken together, our data suggest that p65/c-Jun-mediated DNA looping is involved in TNF-α-induced MMP-9 up-regulation and that the recruitment of p300 or HDAC1 to NFκB and AP-1 binding sites modifies the level of DNA looping. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Late-Holocene climate and environmental change on the Antarctic Peninsula: multi-proxy palaeoclimate records from frozen moss banks

    NASA Astrophysics Data System (ADS)

    Roland, T.; Amesbury, M.; Royles, J.; Hodgson, D.; Convey, P.; Griffiths, H.; Charman, D.

    2017-12-01

    The Antarctic Peninsula (AP) has been one of the most rapidly warming regions on Earth, with air temperature increases of 3°C recorded since the mid-20th century. However, instrumental climate records are mostly limited to the late 1950s onwards and existing palaeoenvironmental data that provide a longer-term context to recent climate and biological changes are often spatially isolated and temporally fragmented. Ice-core records from the AP are not suitably located to be able to examine the spatial signature of climate changes over time. Moss banks located along the western AP are ideal archives for palaeoclimate research as they are well-preserved, have sufficiently high accumulation rates to permit decadally resolved analyses using multiple proxies over the last c. 4000 years, and are easily dated with 14C and 210Pb. Potential climate proxies (moss accumulation and growth rates, Δ13C in moss cellulose, testate amoebae concentration) are sensitive to regional temperature change, moderated by water availability and surface microclimate. Here we present multi-proxy records of biological change from these archives of late Holocene climate variability. We identified significant changepoints in six cores at three sites, across a transect spanning c. 600 km, observing that biological response to recent rapid warming on the AP is pervasive and unprecedented over the last 150 years. Longer records show that recent change is also unusual in the context of the past 4000 years and suggest that westerly wind strength linked to the Southern Annular Mode is the most likely driver of centennial-scale AP temperature variability. Widespread changes in the terrestrial biosphere of the AP in response to past temperature suggest that terrestrial ecosystems will alter rapidly under future warming scenarios, leading to major changes in the biology and landscape of this iconic region — an Antarctic greening to parallel well-established observations in the Arctic.

  11. SEPTUM MAGNET DESIGN FOR THE APS-U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abliz, M.; Jaski, M.; Xiao, A.

    2017-06-25

    The Advanced Photon Source is in the process of upgrading its storage ring from a double-bend to a multi-bend lattice as part of the APS Upgrade Project (APS-U). A swap-out injection scheme is planned for the APS-U to keep a constant beam current and to enable a small dynamic aperture. A septum magnet with a minimum thickness of 2 mm and an injection field of 1.06 T has been designed, delivering the required total deflecting angle is 89 mrad with a ring energy of 6 GeV. The stored beam chamber has an 8 mm x 6 mm super-ellipsoidal aperture. Themore » magnet is straight; however, it is tilted in yaw, roll, and pitch from the stored beam chamber to meet the on axis swap out injection requirements for the APS-U lattice. In order to minimize the leakage field inside the stored beam chamber, four different techniques were utilized in the design. As a result, the horizontal deflecting angle of the stored beam was held to only 5 µrad, and the integrated skew quadrupole inside the stored beam chamber was held to 0.09 T. The detailed techniques that were applied to the design, field multipoles, and resulting trajectories of the injected and stored beams are reported.« less

  12. Professional Certification

    EPA Pesticide Factsheets

    WaterSense recognizes certification programs for irrigation professionals that meet the specification criteria. Certification programs cover three areas: irrigation system design, installation and maintenance, and system auditing.

  13. Efficacy and safety of novel antipsychotics: a critical review.

    PubMed

    Balestrieri, Matteo; Vampini, Claudio; Bellantuono, Cesario

    2000-10-01

    Efficacy and safety of novel antipsychotic (AP) drugs (amisulpride, olanzapine, quetiapine, ziprasidone and zotepine) have been reviewed. Data on their antipsychotic efficacy and side effects profile have been evaluated only on the basis of controlled trials so far published. Overall, all these drugs have shown an antipsychotic efficacy on positive symptoms of schizophrenia similar to that of the conventional AP drugs. On negative symptoms, all novel AP drugs, except quetiapine and ziprasidone, demonstrated a better efficacy than haloperidol. Long-term efficacy of these AP drugs in the maintenance treatment of schizophrenia needs to be explored by further, better-designed, epidemiological studies. The safety profile shows that the novel AP drugs are generally well-tolerated and induce significantly less acute extrapyramidal side effects in comparison with haloperidol. Some methodological flaws in the experimental design of the clinical trials analysed are discussed. Although these novel AP drugs have potential clinical advantages, a number of relevant questions still remain to be addressed, in order to establish the impact of these drugs in the overall treatment of schizophrenia. Copyright 2000 John Wiley & Sons, Ltd.

  14. 50 CFR 622.41 - Species specific limitations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... test and evaluate a new BRD design for up to 60 days without being subject to the observer requirements...) [Reserved] (i) Pre-certification. The pre-certification phase allows a person to test and evaluate a new BRD... vessel specified in the application. The RA will issue a pre-certification phase LOA if the BRD design is...

  15. Thermal Modeling and Cryogenic Design of a Helical Superconducting Undulator Cryostat

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shiroyanagi, Y.; Fuerst, J.; Hasse, Q.

    A conceptual design for a helical superconducting undulator (HSCU) for the Advanced Photon Source (APS) at Argonne National Laboratory (ANL) has been completed. The device differs sufficiently from the existing APS planar superconducting undulator (SCU) design to warrant development of a new cryostat based on value engineering and lessons learned from the existing planar SCU. Changes include optimization of the existing cryocooler-based refrigeration system and thermal shield as well as cost reduction through the use of standard vacuum hardware. The end result is a design that provides significantly larger 4.2 K refrigeration margin in a smaller package for greater installationmore » flexibility in the APS storage ring. This paper presents ANSYS-based thermal analysis of the cryostat, including estimated static and dynamic« less

  16. Assimilation and implications of AE-9/AP-9 in the design process of JPL missions

    NASA Astrophysics Data System (ADS)

    de Soria-Santacruz Pich, M.; Jun, I.

    2015-12-01

    The NASA AE-8/AP-8 has been the standard geospace environment specification for decades. This model describes the energetic particle environment around the Earth and is currently the default model used in the design of space missions at the Jet Propulsion Laboratory (JPL). Moreover, the model plays a critical role in the determination of the shielding and survivability of the satellites orbiting our planet. A recent update supported by the Air Force Research Laboratory (AFRL) and the National Reconnaissance Office (NRO), the AE-9/AP-9 model, was released in September 2012 and included many improvements like increased spatial resolution and the specification of the uncertainty due to instrument errors or space weather variability. A current effort at JPL is in place with the objective of making a decision within the Laboratory on the transition from AE-8/AP-8 to the new AE-9/AP-9. In this study we present the results of this effort, which involves the comparison between both versions of the model for different satellite orbits, the comparison between AE-9/AP-9 and in-situ satellite data from the Van Allen Probes and the OSTM/Jason 2 satellite, and the implications of adopting the new model for spacecraft design in terms of survivability, shielding, single event effects, and spacecraft charging.

  17. Instructional Design Changes in an Undergraduate A&P Course to Facilitate Student Engagement and Interest

    ERIC Educational Resources Information Center

    Hurtt, Barbekka; Bryant, Jennifer

    2016-01-01

    We describe changes in an undergraduate anatomy and physiology (A&P) curriculum designed to address educational goals at a private, comprehensive university. Educational goals included making course material more relevant to students' future career interests, exposing students to professionals in their careers of interest, and incorporating…

  18. X-ray performance of 0.18 µm CMOS APS test arrays for solar observation

    NASA Astrophysics Data System (ADS)

    Dryer, B. J.; Holland, A. D.; Jerram, P.; Sakao, Taro

    2012-07-01

    Solar-C is the third generation solar observatory led by JAXA. The accepted ‘Plan-B’ payload calls for a radiation-hard solar-staring photon-counting x-ray spectrometer. CMOS APS technology offers advantages over CCDs for such an application such as increased radiation hardness and high frame rate (instrument target of 1000 fps). Looking towards the solution of a bespoke CMOS APS, this paper reports the x-ray spectroscopy performance, concentrating on charge collection efficiency and split event analysis, of two baseline e2v CMOS APSs not designed for x-ray performance, the EV76C454 and the Ocean Colour Imager (OCI) test array. The EV76C454 is an industrial 5T APS designed for machine vision, available back and front illuminated. The OCI test arrays have varying pixel design across the chips, but are 4T, back illuminated and have thin low-resistivity and thick high-resistivity variants. The OCI test arrays’ pixel variants allow understanding of how pixel design can affect x-ray performance.

  19. Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity

    PubMed Central

    Shakespeare, William; Yang, Michael; Bohacek, Regine; Cerasoli, Franklin; Stebbins, Karin; Sundaramoorthi, Raji; Azimioara, Mihai; Vu, Chi; Pradeepan, Selvi; Metcalf, Chester; Haraldson, Chad; Merry, Taylor; Dalgarno, David; Narula, Surinder; Hatada, Marcos; Lu, Xiaode; van Schravendijk, Marie Rose; Adams, Susan; Violette, Shelia; Smith, Jeremy; Guan, Wei; Bartlett, Catherine; Herson, Jay; Iuliucci, John; Weigele, Manfred; Sawyer, Tomi

    2000-01-01

    Targeted disruption of the pp60src (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Herein we describe the discovery of a nonpeptide inhibitor (AP22408) of Src that demonstrates in vivo antiresorptive activity. Based on a cocrystal structure of the noncatalytic Src homology 2 (SH2) domain of Src complexed with citrate [in the phosphotyrosine (pTyr) binding pocket], we designed 3′,4′-diphosphonophenylalanine (Dpp) as a pTyr mimic. In addition to its design to bind Src SH2, the Dpp moiety exhibits bone-targeting properties that confer osteoclast selectivity, hence minimizing possible undesired effects on other cells that have Src-dependent activities. The chemical structure AP22408 also illustrates a bicyclic template to replace the post-pTyr sequence of cognate Src SH2 phosphopeptides such as Ac-pTyr-Glu-Glu-Ile (1). An x-ray structure of AP22408 complexed with Lck (S164C) SH2 confirmed molecular interactions of both the Dpp and bicyclic template of AP22408 as predicted from molecular modeling. Relative to the cognate phosphopeptide, AP22408 exhibits significantly increased Src SH2 binding affinity (IC50 = 0.30 μM for AP22408 and 5.5 μM for 1). Furthermore, AP22408 inhibits rabbit osteoclast-mediated resorption of dentine in a cellular assay, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay, and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. PMID:10944210

  20. The APS SASE FEL : modeling and code comparison.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Biedron, S. G.

    A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

  1. The Pursuit of Leadership in Energy and Environmental Design (LEED) Certification for Campus Housing at Public Universities

    ERIC Educational Resources Information Center

    Konvalinka, April Hicks

    2014-01-01

    This dissertation identifies the reasons why institutions of higher education pursue Leadership in Energy and Environmental Design (LEED) certification for new construction of campus housing. The research was guided by three questions: 1. Why did the institution choose to pursue LEED certification for campus housing? 2. What considerations should…

  2. Installation Restoration Program. Phase 2. Confirmation/Quantification Stage 1 for Pease Air Force Base, New Hampshire. Volume 1.

    DTIC Science & Technology

    1987-08-01

    01 0 4 In w el4 ’ n r fl f4 r, V 0 𔃾 1" * * * - ~ m ~c- I0 1-0- Q~ 3c 3c~ AdI-. * tp~dip Eu - 4j :: .( - * -U I’ -L - UJ a. Zw a Inc., ɘ L.3. 2-3...swale ap- proximately 100 feet south of Building 222 (Figure 3-7), the Jet Engine Test cell . With the exception of VOC, all param- eters detected at 15-B

  3. Coverage of Continuous Regions in Euclidean Space Using Homogeneous Resources with Application to the Allocation of the Phased Array Radar Systems

    DTIC Science & Technology

    2011-06-01

    centered at OPi with radius β. Let δ ∗ be the coverage level of the entire polygon P , AP be the area of polygon P , APi be the area of sub-polygon...30 1104 512 1120 992 512 297 1.72 40 600 512 480 544 480 167 2.87 80 158 128 120 136 120 42 2.86 120 70 32 70 62 32 19 1.68 160 38 32 30 34 30 11

  4. 14th International Congress on Antiphospholipid Antibodies: task force report on antiphospholipid syndrome treatment trends.

    PubMed

    Erkan, Doruk; Aguiar, Cassyanne L; Andrade, Danieli; Cohen, Hannah; Cuadrado, Maria J; Danowski, Adriana; Levy, Roger A; Ortel, Thomas L; Rahman, Anisur; Salmon, Jane E; Tektonidou, Maria G; Willis, Rohan; Lockshin, Michael D

    2014-06-01

    Antiphospholipid Syndrome (APS) is characterized by vascular thrombosis and/or pregnancy morbidity occurring in patients with persistent antiphospholipid antibodies (aPL). The primary objective of the APS Treatment Trends Task Force, created as part of the 14th International Congress on aPL, was to systematically review the potential future treatment strategies for aPL-positive patients. The task force chose as future clinical research directions: a) determining the necessity for controlled clinical trials in venous thromboembolism with the new oral direct thrombin or anti-factor Xa inhibitors pending the results of the ongoing rivaroxaban in APS (RAPS) trial, and designing controlled clinical trials in other forms of thrombotic APS; b) systematically analyzing the literature as well as aPL/APS registries, and creating specific registries for non-warfarin/heparin anticoagulants; c) increasing recruitment for an ongoing primary thrombosis prevention trial, and designing secondary thrombosis and pregnancy morbidity prevention trials with hydroxychloroquine; d) determining surrogate markers to select patients for statin trials; e) designing controlled studies with rituximab and other anti-B-cell agents; f) designing mechanistic and clinical studies with eculizumab and other complement inhibitors; and g) chemically modifying peptide therapy to improve the half-life and minimize immunogenicity. The report also includes recommendations for clinicians who consider using these agents in difficult-to-manage aPL-positive patients. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. A West Valley Demonstration Project Milestone - Achieving Certification to Ship Waste to the Nevada Test Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jackson, J. P.; Pastor, R. S.

    2002-02-28

    The West Valley Demonstration Project (WVDP) has successfully pretreated and vitrified nearly all of the 600,000 gallons of liquid high-level radioactive waste that was generated at the site of the only commercial nuclear fuel reprocessing plant to have operated in the United States. Low-level waste (LLW) generated during the course of the cleanup effort now requires disposal. Currently the WVDP only ships Class A LLW for off-site disposal. It has been shipping Class A wastes to Envirocare of Utah, Inc. since 1997. However, the WVDP may also have a future need to ship Class B and Class C waste, whichmore » Envirocare is not currently authorized to accept. The Nevada Test Site (NTS), a U.S. Department of Energy (DOE) facility, can accept all three waste classifications. The WVDP set a goal to receive certification to begin shipping Class A wastes to NTS by 2001. Formal certification/approval was granted by the DOE Nevada Operations Office on July 12, 2001. This paper discusses how the WVDP contractor, West Valley Nuclear Services Company (WVNSCO), completed the activities required to achieve NTS certification in 2001 to ship waste to its facility. The information and lessons learned provided are significant because the WVDP is the only new generator receiving certification based on an NTS audit in January 2001 that resulted in no findings and only two observations--a rating that is unparalleled in the DOE Complex.« less

  6. Postgraduate education in laboratory medicine and certification/re-certification of clinical pathologists in Taiwan.

    PubMed

    Sun, Chien-Feng

    2004-04-01

    The Taiwan Society of Clinical Pathologists (TSCP) plays a central role in postgraduate education of laboratory medicine and the certification/re-certification of clinical pathologists in Taiwan. For the certification of clinical pathologists, TSCP establishes "Guidelines and Scope of Resident Training" and "Standards for Training Hospitals in Clinical Pathology(CP)", administers board examinations, and issues board certifications/re-certifications. There are two types of CP resident training programs, including a straight CP program with 3 years of CP training for a CP certificate and a combined program with 3 years of Anatomic Pathology training and 2 years of CP training for both the CP and AP certificates. The core curriculum for CP training includes: (1) Clinical Chemistry (at least 4 months), (2) Clinical Microscope with Parasitology (at least 3 months), (3) Clinical Hematology (at least 4 months), and (4) Clinical Microbiology with Clinical Virology (at least 4 months), (5) Immunohematology and Blood Banking (Transfusion Medicine) (at least 3 months), (6) Clinical Serology and Immunology(at least 4 months), and (7) Laboratory Management (at least 2 months). The curriculum for third-year training is not specified and may be in any field. In recent years, the board examination has emphasized the topics of Molecular Biology and Laboratory Informatics. The TSCP has also established an accreditation and inspection program for the CP resident raining hospitals. Each accredited CP training hospital is required to have a detailed teaching protocol of CP training. Quotas are assigned according to the available CPs of the accredited hospitals. The accreditation period is 3 years. Through sponsoring scientific and educational programs, the TSCP offers credit hours of education in laboratory medicine, which are required for re-certification of CPs in Taiwan. The members of the TSCP meet at least twice a year for scientific presentations and seminars. In addition, two to four symposia, offering 8 credit hours each, are held each year in various subspecialties of CP. In 2003, 22 hospitals were accredited as CP training hospitals for a total quota of 26. Until 2003, the TSCP had certified 116 CPs. At the present time, only 103 certified CPs are actively practicing laboratory medicine. Re-certification requires 100 credit hours of continuing education. The requirements for board certification and re-certification are the two main driving forces for CPs in Taiwan to seek continuing education. Our model of education for CPs has proven to be effective. The number of practicing CPs increased from 21 (one per 3,083 beds) in 1991 to 103 (one per 929 beds) in 2002. Most of the CPs are associated with medical centers(62/103, 60.2%) and regional hospitals(38/103, 36.9%).

  7. 78 FR 37885 - Approval of American Society of Mechanical Engineers' Code Cases

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ...), standard design certifications, standard design approvals and manufacturing licenses, to use the Code Cases... by the ASME. The three RGs that would be incorporated by reference are RG 1.84, ``Design, Fabrication... nuclear power plant licensees, and applicants for CPs, OLs, COLs, standard design certifications, standard...

  8. Dynamic (Vibration) Testing: Design-Certification of Aerospace System

    NASA Technical Reports Server (NTRS)

    Aggarwal, Pravin K.

    2010-01-01

    Various types of dynamic testing of structures for certification purposes are described, including vibration, shock and acoustic testing. Modal testing is discussed as it frequently complements dynamic testing and is part of the structural verification/validation process leading up to design certification. Examples of dynamic and modal testing are presented as well as the common practices, procedures and standards employed.

  9. AP-102/104 Retrieval control system qualification test procedure

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    RIECK, C.A.

    1999-05-18

    This Qualification Test Procedure documents the results of the qualification testing that was performed on the Project W-211, ''Initial Tank Retrieval Systems,'' retrieval control system (RCS) for tanks 241-AP-102 and 241-AP-104. The results confirm that the RCS has been programmed correctly and that the two related hardware enclosures have been assembled in accordance with the design documents.

  10. The Impact of AP® Achievement Institute I on Students' AP Performance. Research Report No. 2012-7

    ERIC Educational Resources Information Center

    Bausmith, Jennifer Merriman; Laitusis, Vytas

    2012-01-01

    The AP Achievement Institute I (APAI I) is a four-day professional development program offered to teachers and administrators by EXCELerator™, a district reform program operated by the College Board. The APAI I program is designed to help teachers develop effective AP instructional strategies for a diverse student body and to help district,…

  11. The power of simplification: Operator interface with the AP1000{sup R} during design-basis and beyond design-basis events

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Williams, M. G.; Mouser, M. R.; Simon, J. B.

    2012-07-01

    The AP1000{sup R} plant is an 1100-MWe pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance, safety and cost. The passive safety features are designed to function without safety-grade support systems such as component cooling water, service water, compressed air or HVAC. The AP1000 passive safety features achieve and maintain safe shutdown in case of a design-basis accident for 72 hours without need for operator action, meeting the expectations provided in the European Utility Requirements and the Utility Requirement Document for passive plants. Limited operator actions may be required to maintain safe conditionsmore » in the spent fuel pool (SFP) via passive means. This safety approach therefore minimizes the reliance on operator action for accident mitigation, and this paper examines the operator interaction with the Human-System Interface (HSI) as the severity of an accident increases from an anticipated transient to a design basis accident and finally, to a beyond-design-basis event. The AP1000 Control Room design provides an extremely effective environment for addressing the first 72 hours of design-basis events and transients, providing ease of information dissemination and minimal reliance upon operator actions. Symptom-based procedures including Emergency Operating Procedures (EOPs), Abnormal Operating Procedures (AOPs) and Alarm Response Procedures (ARPs) are used to mitigate design basis transients and accidents. Use of the Computerized Procedure System (CPS) aids the operators during mitigation of the event. The CPS provides cues and direction to the operators as the event progresses. If the event becomes progressively worse or lasts longer than 72 hours, and depending upon the nature of failures that may have occurred, minimal operator actions may be required outside of the control room in areas that have been designed to be accessible using components that have been designed to be reliable in these conditions. The primary goal of any such actions is to maintain or refill the passive inventory available to cool the core, containment and spent fuel pool in the safety-related and seismically qualified Passive Containment Cooling Water Storage Tank (PCCWST). The seismically-qualified, ground-mounted Passive Containment Cooling Ancillary Water Storage Tank (PCCAWST) is also available for this function as appropriate. The primary effect of these actions would be to increase the coping time for the AP1000 during design basis events, as well as events such as those described above, from 72 hours without operator intervention to 7 days with minimal operator actions. These Operator actions necessary to protect the health and safety of the public are addressed in the Post-72 Hour procedures, as well as some EOPs, AOPs, ARPs and the Severe Accident Management Guidelines (SAMGs). Should the event continue to become more severe and plant conditions degrade further with indications of inadequate core cooling, the SAMGs provide guidance for strategies to address these hypothetical severe accident conditions. The AP1000 SAMG diagnoses and actions are prioritized to first utilize the AP1000 features that are expected to retain a damaged core inside the reactor vessel. Only one strategy is undertaken at any time. This strategy will be followed and its effectiveness evaluated before other strategies are undertaken. This is a key feature of both the symptom-oriented AP1000 EOPs and the AP1000 SAMGs which maximizes the probability of retaining a damaged core inside the reactor vessel and containment while minimizing the chances for confusion and human errors during implementation. The AP1000 SAMGs are simple and straight-forward and have been developed with considerable input from human factors and plant operations experts. Most importantly, and different from severe accident management strategies for other plants, the AP1000 SAMGs do not require diagnosis of the location of the core (i.e., whether reactor vessel failure has occurred). This is a fundamental consequence of the AP1000 In-Vessel Retention approach, which allows severe accident management to be based on fundamental principles (e.g. provide coolant as close as possible to the core) that do not change during a specific event. This eliminates the need for one of the more difficult diagnostic requirements, since reactor vessel failure does not directly relate to any measurable plant parameter, and differs from other designs in that an engineered failure of the pressure vessel' (e.g. core catcher) is never required. (authors)« less

  12. Human factors certification in the development of future air traffic control systems

    NASA Technical Reports Server (NTRS)

    Evans, Alyson E.

    1994-01-01

    If human factors certification of aviation technologies aims to encompass the wide range of issues which need to be addressed for any new system, then human factors involvement must be present throughout the whole design process in a manner which relates to final certification. A certification process cannot simply be applied to the final product of design. Standards and guidelines will be required by designers at the outset of design for reference in preparing for certification. The most effective use of human factors principles, methods, and measures is made as part of an iterative design process, leading to a system which reflects these as far as possible. This particularly applies where the technology is complex and may be represented by a number of components or sub-systems. Some aspects of the system are best certified during early prototyping, when there is still scope to make changes to software or hardware. At this stage in design, financial and/or time pressures will not rule out the possibility of necessary changes, as may be the case later. Other aspects of the system will be best certified during the final phases of design when the system is in a more complete form and in a realistic environment.

  13. State of Alaska Fire Service Training. Instructor Certification Standards.

    ERIC Educational Resources Information Center

    Hagevig, William

    Designed for local Alaskan fire departments, this pamphlet provides the criteria and qualifications for certificates of firefighter instructors (basic, advanced, master), a list of approved subject categories for each level of certification, sample certification applications, a list of resource publications, and a training course outline (basic…

  14. 14 CFR 21.119 - Privileges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... for installation on certificated aircraft; and (c) Obtain a production certificate for the change in the type design that was approved by that supplemental type certificate. Effective Date Note: By Amdt... production certificate in accordance with the requirements of subpart G of this part for the change in the...

  15. 22 CFR 123.14 - Import certificate/delivery verification procedure.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.14 Import certificate/delivery verification procedure. (a) The Import Certificate/Delivery Verification Procedure is designed to assure that a commodity... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Import certificate/delivery verification...

  16. 22 CFR 123.14 - Import certificate/delivery verification procedure.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.14 Import certificate/delivery verification procedure. (a) The Import Certificate/Delivery Verification Procedure is designed to assure that a commodity... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Import certificate/delivery verification...

  17. Alternative Teacher Certification--An Update. ERIC Digest.

    ERIC Educational Resources Information Center

    Otuya, Ebo

    This digest reviews alternative certification on the basis of educational quality and the need to fill teacher shortages. Following a definition of traditional certification, the alternative certification route is described as a process designed to certify candidates who have subject-matter competencies, without going through formal teacher…

  18. Diagnostic and Prognostic Significance of DSM-5 Attenuated Psychosis Syndrome in Services for Individuals at Ultra High Risk for Psychosis.

    PubMed

    Fusar-Poli, Paolo; De Micheli, Andrea; Cappucciati, Marco; Rutigliano, Grazia; Davies, Cathy; Ramella-Cravaro, Valentina; Oliver, Dominic; Bonoldi, Ilaria; Rocchetti, Matteo; Gavaghan, Lauren; Patel, Rashmi; McGuire, Philip

    2018-02-15

    The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion of psychosis risk is unknown. Prospective cohort study including all consecutive help-seeking individuals undergoing both a DSM-5-APS and a Comprehensive Assessment of At Risk Mental States (CAARMS 12/2006) assessment for psychosis risk at the Outreach and Support in South London (OASIS) UHR service (March 2013-April 2014). The diagnostic significance of DSM-5-APS was assessed with percent overall agreement, prevalence bias adjusted kappa, Bowker's test, Stuart-Maxwell test, residual analysis; the prognostic significance with Cox regression, Kaplan-Meier failure function, time-dependent area under the curve (AUC) and net benefits analysis. The impact of specific revisions of the DSM-5-APS was further tested. In 203 help-seeking individuals undergoing UHR assessment, the agreement between the DSM-5-APS and the CAARMS 12/2006 was only moderate (kappa 0.59). Among 142 nonpsychotic cases, those meeting DSM-5-APS criteria had a 5-fold probability (HR = 5.379) of developing psychosis compared to those not meeting DSM-5-APS criteria, with a 21-month cumulative risk of psychosis of 28.17% vs 6.49%, respectively. The DSM-5-APS prognostic accuracy was acceptable (AUC 0.76 at 24 months) and similar to the CAARMS 12/2006. The DSM-5-APS designation may be clinically useful to guide the provision of indicated interventions within a 7%-35% (2-year) range of psychosis risk. The removal of the criterion E or C of the DSM-5-APS may improve its prognostic performance and transdiagnostic value. The DSM-5-APS designation may be clinically useful in individuals accessing clinical services for psychosis prevention. © The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com

  19. A Model for Low-Frequency Earthquake Slip

    NASA Astrophysics Data System (ADS)

    Chestler, S. R.; Creager, K. C.

    2017-12-01

    Using high-resolution relative low-frequency earthquake (LFE) locations, we calculate the patch areas (Ap) of LFE families. During episodic tremor and slip (ETS) events, we define AT as the area that slips during LFEs and ST as the total amount of summed LFE slip. Using observed and calculated values for AP, AT, and ST, we evaluate two end-member models for LFE slip within an LFE family patch. In the ductile matrix model, LFEs produce 100% of the observed ETS slip (SETS) in distinct subpatches (i.e., AT ≪ AP). In the connected patch model, AT = AP, but ST ≪ SETS. LFEs cluster into 45 LFE families. Spatial gaps (˜10 to 20 km) between LFE family clusters and smaller gaps within LFE family clusters serve as evidence that LFE slip is heterogeneous on multiple spatial scales. We find that LFE slip only accounts for ˜0.2% of the slip within the slow slip zone. There are depth-dependent trends in the characteristic (mean) moment and in the number of LFEs during both ETS events (only) and the entire ETS cycle (Mcets and NTets and Mcall and NTall, respectively). During ETS, Mc decreases with downdip distance but NT does not change. Over the entire ETS cycle, Mc decreases with downdip distance, but NT increases. These observations indicate that deeper LFE slip occurs through a larger number (800-1,200) of small LFEs, while updip LFE slip occurs primarily during ETS events through a smaller number (200-600) of larger LFEs. This could indicate that the plate interface is stronger and has a higher stress threshold updip.

  20. Liquid chromatographic-tandem mass spectrometric method for the simultaneous determination of alkylphenols polyethoxylates, alkylphenoxy carboxylates and alkylphenols in wastewater and surface-water.

    PubMed

    Ciofi, L; Ancillotti, C; Chiuminatto, U; Fibbi, D; Checchini, L; Orlandini, S; Del Bubba, M

    2014-10-03

    Four different pellicular stationary phases (i.e. octadecylsilane, octasilane, Phenyl-Hexyl and pentafluorophenyl) were investigated for the chromatographic resolution of alkylphenols (APs), alkylphenols polyethoxylates (APnEOs) and alkylphenoxy carboxylates (APECs) using mixtures of water and organic solvents (i.e. methanol, acetonitrile and tetrahydrofuran) as eluents, in order to obtain their determination by a single LC-MS/MS run. In fact, alkylphenols and alkylphenoxy carboxylates must be analysed in negative ion mode, whereas alkylphenols polyethoxylates undergo ionisation only in positive ion mode, and therefore, two distinct LC-MS/MS analysis are commonly adopted. The best resolution among the aforementioned target analytes was achieved on the pentafluorophenyl column, eluting with an acidified water-acetonitrile-tetrahydrofuran mixture and using the post column addition of an ammonia solution in methanol for the detection of positively ionisable compounds. Under these optimized chromatographic conditions the investigated compounds were determined via a single chromatographic run, with only one polarity switch, in 15min, achieving the following instrumental detection limits: 600pg for AP1EOs, 0.8-14pg for AP2EOs, 10.4-150pg for APs and 4.4-4.8pg for APECs. The chromatographic method was coupled with solid-phase extraction and clean-up procedures and successfully applied to the analysis of wastewater and surface water samples, highlighting mean concentration ranging from 6ng/L for 4-t-OP1EC to 1434ng/L for 4-NP1121EC, depending on the sample analysed. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. 14 CFR 21.463 - Supplemental type certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... for which the STC is to be issued, as modified by the supplemental type design data upon which the STC... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Supplemental type certificates. 21.463... Procedures § 21.463 Supplemental type certificates. (a) For each supplemental type certificate issued under...

  2. 45 CFR 146.115 - Certification and disclosure of previous coverage.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... in a reasonable and prompt fashion, can provide the certificate. A certificate is required to be... earliest date that the plan, acting in a reasonable and prompt fashion, can provide certificates. (ii... to establish rules designed to prevent an individual's subsequent coverage under a group health plan...

  3. Wisconsin Certification Manual for Public Librarians. Bulletin No. 7075.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison. Div. of Library Services.

    Designed to be used as a guide for public librarians and boards of trustees in meeting the requirements of Wisconsin's public librarian certification law, this manual is divided into two major sections covering public librarian certification and certification renewal/continuing education requirements. The first section includes discussions of…

  4. 14 CFR 21.93 - Classification of changes in type design.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Classification of changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.93 Classification of changes in type design. (a) In addition to changes in type design specified in paragraph (b) of...

  5. Design certification tests: High Pressure Oxygen Filter (HPOF) program. Summary report

    NASA Technical Reports Server (NTRS)

    Smith, I. D.

    1976-01-01

    Design and acceptance certification test procedures and results are presented for a high pressure oxygen filter developed to protect the sealing surfaces in emergency oxygen systems. Equipment specifications are included.

  6. N-acetylcysteine does not prevent post-endoscopic retrograde cholangiopancreatography hyperamylasemia and acute pancreatitis

    PubMed Central

    Milewski, Janusz; Rydzewska, Grazyna; Degowska, Malgorzata; Kierzkiewicz, Maciej; Rydzewski, Andrzej

    2006-01-01

    AIM: Acute pancreatitis (AP) is the most common and often severe complication of endoscopic retrograde cholangiopancreatography (ERCP). The early step in the pathogenesis of acute pancreatitis is probably the capillary endothelial injury mediated by oxygen-derived free radicals. N-acetylcysteine - a free radical scavenger may be potentially effective in preventing post-ERCP acute pancreatitis and it is also known that N-acetylcysteine (ACC) can reduce the severity of disease in experimental model of AP. METHODS: One hundred and six patients were randomly allocated to two groups. Fifty-five patients were given N-acetylcysteine (two 600 mg doses orally 24 and 12 h before ERCP and 600 mg was given iv, twice a day for two days after the ERCP). The control group consisted of 51 patients who were given iv. isotonic saline twice a day for two days after the ERCP. Serum and urine amylase activities were measured before ERCP and 8 and 24 h after the procedure. The primary outcome parameter was post-ERCP acute pancreatitis and the secondary outcome parameters were differences between groups in serum and urine amylase activity. RESULTS: There were no significant differences in the rate of post-ERCP pancreatitis between two groups (10 patients overall, 4 in the ACC group and 6 in the control group). There were also no significant differences in baseline and post-ERCP serum and urine amylase activity between ACC group and control group. CONCLUSION: N-acetylcysteine fails to demonstrate any significant preventive effect on post-ERCP pancreatitis, as well as on serum and urine amylase activity. PMID:16773694

  7. N-acetylcysteine does not prevent post-endoscopic retrograde cholangiopancreatography hyperamylasemia and acute pancreatitis.

    PubMed

    Milewski, Janusz; Rydzewska, Grazyna; Degowska, Malgorzata; Kierzkiewicz, Maciej; Rydzewski, Andrzej

    2006-06-21

    Acute pancreatitis (AP) is the most common and often severe complication of endoscopic retrograde cholangiopancreatography (ERCP). The early step in the pathogenesis of acute pancreatitis is probably the capillary endothelial injury mediated by oxygen-derived free radicals. N-acetylcysteine - a free radical scavenger may be potentially effective in preventing post-ERCP acute pancreatitis and it is also known that N-acetylcysteine (ACC) can reduce the severity of disease in experimental model of AP. One hundred and six patients were randomly allocated to two groups. Fifty-five patients were given N-acetylcysteine (two 600 mg doses orally 24 and 12 h before ERCP and 600 mg was given iv, twice a day for two days after the ERCP). The control group consisted of 51 patients who were given iv. isotonic saline twice a day for two days after the ERCP. Serum and urine amylase activities were measured before ERCP and 8 and 24 h after the procedure. The primary outcome parameter was post-ERCP acute pancreatitis and the secondary outcome parameters were differences between groups in serum and urine amylase activity. There were no significant differences in the rate of post-ERCP pancreatitis between two groups (10 patients overall, 4 in the ACC group and 6 in the control group). There were also no significant differences in baseline and post-ERCP serum and urine amylase activity between ACC group and control group. N-acetylcysteine fails to demonstrate any significant preventive effect on post-ERCP pancreatitis, as well as on serum and urine amylase activity.

  8. Promoting the APS Chapter Program by Sharing Its History, Best Practices, and How-to Guide for Establishing New Chapters

    ERIC Educational Resources Information Center

    Hopper, Mari K.

    2017-01-01

    Early establishment of physiological societies in Oklahoma and Ohio demonstrated the benefits of networking physiologists and paved the way for establishing the APS Chapter Program. Designed to promote the general objectives of the APS, the Chapter Program was officially launched in 1995, with Ohio being the first recognized chapter. There are 13…

  9. Benefits and barriers among volunteer teaching faculty: comparison between those who precept and those who do not in the core pediatrics clerkship.

    PubMed

    Ryan, Michael S; Vanderbilt, Allison A; Lewis, Thasia W; Madden, Molly A

    2013-01-01

    Background Community-based outpatient experiences are a core component of the clinical years in medical school. Central to the success of this experience is the recruitment and retention of volunteer faculty from the community. Prior studies have identified reasons why some preceptors volunteer their time however, there is a paucity of data comparing those who volunteer from those who do not. Methods A survey was developed following a review of previous studies addressing perceptions of community-based preceptors. A non-parametric, Mann-Whitney U test was used to compare active preceptors (APs) and inactive preceptors (IPs) and all data were analyzed in SPSS 20.0. Results There was a 28% response rate. Preceptors showed similar demographic characteristics, valued intrinsic over extrinsic benefits, and appreciated Continuing Medical Education (CME)/Maintenance of Certification (MOC) opportunities as the highest extrinsic reward. APs were more likely to also precept at the M1/M2 level and value recognition and faculty development opportunities (p<0.05). IPs denoted time as the most significant barrier and, in comparison to APs, rated financial compensation as more important (p<0.05). Conclusions Community preceptors are motivated by intrinsic benefits of teaching. Efforts to recruit should initially focus on promoting awareness of teaching opportunities and offering CME/MOC opportunities. Increasing the pool of preceptors may require financial compensation.

  10. Benefits and barriers among volunteer teaching faculty: comparison between those who precept and those who do not in the core pediatrics clerkship.

    PubMed

    Ryan, Michael S; Vanderbilt, Allison A; Lewis, Thasia W; Madden, Molly A

    2013-05-03

    Community-based outpatient experiences are a core component of the clinical years in medical school. Central to the success of this experience is the recruitment and retention of volunteer faculty from the community. Prior studies have identified reasons why some preceptors volunteer their time however, there is a paucity of data comparing those who volunteer from those who do not. A survey was developed following a review of previous studies addressing perceptions of community-based preceptors. A non-parametric, Mann-Whitney U test was used to compare active preceptors (APs) and inactive preceptors (IPs) and all data were analyzed in SPSS 20.0. There was a 28% response rate. Preceptors showed similar demographic characteristics, valued intrinsic over extrinsic benefits, and appreciated Continuing Medical Education (CME)/Maintenance of Certification (MOC) opportunities as the highest extrinsic reward. APs were more likely to also precept at the M1/M2 level and value recognition and faculty development opportunities (p<0.05). IPs denoted time as the most significant barrier and, in comparison to APs, rated financial compensation as more important (p<0.05). Community preceptors are motivated by intrinsic benefits of teaching. Efforts to recruit should initially focus on promoting awareness of teaching opportunities and offering CME/MOC opportunities. Increasing the pool of preceptors may require financial compensation.

  11. 76 FR 28914 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... of the rudder system design. Rudder pedal sensitivity on Model A300-600 and A310 series airplanes is... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes); and Model A310 Series Airplanes AGENCY: Federal Aviation...

  12. 10 CFR 51.55 - Environmental report-standard design certification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... environmental report must address whether the design change which is the subject of the proposed amendment... 10 Energy 2 2011-01-01 2011-01-01 false Environmental report-standard design certification. 51.55 Section 51.55 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR...

  13. Quantitative analysis of the Ca2+‐dependent regulation of delayed rectifier K+ current I Ks in rabbit ventricular myocytes

    PubMed Central

    Bartos, Daniel C.; Morotti, Stefano; Ginsburg, Kenneth S.; Grandi, Eleonora

    2017-01-01

    Key points [Ca2+]i enhanced rabbit ventricular slowly activating delayed rectifier K+ current (I Ks) by negatively shifting the voltage dependence of activation and slowing deactivation, similar to perfusion of isoproterenol.Rabbit ventricular rapidly activating delayed rectifier K+ current (I Kr) amplitude and voltage dependence were unaffected by high [Ca2+]i.When measuring or simulating I Ks during an action potential, I Ks was not different during a physiological Ca2+ transient or when [Ca2+]i was buffered to 500 nm. Abstract The slowly activating delayed rectifier K+ current (I Ks) contributes to repolarization of the cardiac action potential (AP). Intracellular Ca2+ ([Ca2+]i) and β‐adrenergic receptor (β‐AR) stimulation modulate I Ks amplitude and kinetics, but details of these important I Ks regulators and their interaction are limited. We assessed the [Ca2+]i dependence of I Ks in steady‐state conditions and with dynamically changing membrane potential and [Ca2+]i during an AP. I Ks was recorded from freshly isolated rabbit ventricular myocytes using whole‐cell patch clamp. With intracellular pipette solutions that controlled free [Ca2+]i, we found that raising [Ca2+]i from 100 to 600 nm produced similar increases in I Ks as did β‐AR activation, and the effects appeared additive. Both β‐AR activation and high [Ca2+]i increased maximally activated tail I Ks, negatively shifted the voltage dependence of activation, and slowed deactivation kinetics. These data informed changes in our well‐established mathematical model of the rabbit myocyte. In both AP‐clamp experiments and simulations, I Ks recorded during a normal physiological Ca2+ transient was similar to I Ks measured with [Ca2+]i clamped at 500–600 nm. Thus, our study provides novel quantitative data as to how physiological [Ca2+]i regulates I Ks amplitude and kinetics during the normal rabbit AP. Our results suggest that micromolar [Ca2+]i, in the submembrane or junctional cleft space, is not required to maximize [Ca2+]i‐dependent I Ks activation during normal Ca2+ transients. PMID:28008618

  14. Crab Cavity and Cryomodule Prototype Development for the Advanced Photon Source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, H; Ciovati, G; Clemens, W A

    2011-03-01

    We review the single-cell, superconducting crab cavity designs for the short-pulse x-ray (SPX) project at the Advanced Photon Source (APS). The 'on-cell' waveguide scheme is expected to have a more margin for the impedance budget of the APS storage ring, as well as offering a more compact design compared with the original design consisting of a low order mode damping waveguide on the beam pipe. We will report recent fabrication progress, cavity test performance on original and alternate prototypes, and concept designs and analysis for various cryomodule components.

  15. 46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... for inspection on Form CG-3752; and (2) Evidence that the vessel has been designated as a sailing...

  16. 46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... for inspection on Form CG-3752; and (2) Evidence that the vessel has been designated as a sailing...

  17. Space shuttle redesigned solid rocket motor Certificate of Qualification (COQ) data report

    NASA Technical Reports Server (NTRS)

    Duersch, Fred, Jr.

    1990-01-01

    The Space Shuttle Redesigned Solid Rocket Motor (RSRM) Certification Program provides confidence that the RSRM and its components/subsystems meet or exceed Mission Oriented Requirements when manufactured per design requirements and specified/approved processes. Certification is based on documented results of tests, analyses, inspections, similarity, and demonstrations. Evidencing information is provided to certify that each RSRM component/subsystem satisfies design, mission related requirements and objectives.

  18. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  19. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  20. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  1. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  2. 14 CFR 21.95 - Approval of minor changes in type design.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Approval of minor changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.95 Approval of minor changes in type design. Minor changes in a type design may be approved under a method...

  3. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 2.

    PubMed

    McBride, Christopher; Cheruvallath, Zacharia; Komandla, Mallareddy; Tang, Mingnam; Farrell, Pamela; Lawson, J David; Vanderpool, Darin; Wu, Yiqin; Dougan, Douglas R; Plonowski, Artur; Holub, Corine; Larson, Chris

    2016-06-15

    Methionine aminopeptidase-2 (MetAP2) is an enzyme that cleaves an N-terminal methionine residue from a number of newly synthesized proteins. This step is required before they will fold or function correctly. Pre-clinical and clinical studies with a MetAP2 inhibitor suggest that they could be used as a novel treatment for obesity. Herein we describe the discovery of a series of pyrazolo[4,3-b]indoles as reversible MetAP2 inhibitors. A fragment-based drug discovery (FBDD) approach was used, beginning with the screening of fragment libraries to generate hits with high ligand-efficiency (LE). An indazole core was selected for further elaboration, guided by structural information. SAR from the indazole series led to the design of a pyrazolo[4,3-b]indole core and accelerated knowledge-based fragment growth resulted in potent and efficient MetAP2 inhibitors, which have shown robust and sustainable body weight loss in DIO mice when dosed orally. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. 40 CFR 97.310 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administrator of a complete certificate of representation under § 97.313, the CAIR designated representative of the source shall represent and, by his or her representations, actions, inactions, or submissions... Administrator has received a complete certificate of representation under § 97.313 for a CAIR designated...

  5. 40 CFR 97.310 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Administrator of a complete certificate of representation under § 97.313, the CAIR designated representative of the source shall represent and, by his or her representations, actions, inactions, or submissions... Administrator has received a complete certificate of representation under § 97.313 for a CAIR designated...

  6. 40 CFR 97.310 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Administrator of a complete certificate of representation under § 97.313, the CAIR designated representative of the source shall represent and, by his or her representations, actions, inactions, or submissions... Administrator has received a complete certificate of representation under § 97.313 for a CAIR designated...

  7. 40 CFR 97.310 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Administrator of a complete certificate of representation under § 97.313, the CAIR designated representative of the source shall represent and, by his or her representations, actions, inactions, or submissions... Administrator has received a complete certificate of representation under § 97.313 for a CAIR designated...

  8. 40 CFR 97.310 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Administrator of a complete certificate of representation under § 97.313, the CAIR designated representative of the source shall represent and, by his or her representations, actions, inactions, or submissions... Administrator has received a complete certificate of representation under § 97.313 for a CAIR designated...

  9. 14 CFR 26.21 - Limit of validity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... inspection results, of high-time airplanes of similar structural design, accounting for differences in... whether the maximum takeoff gross weight is a result of an original type certificate or a later design... certificate issued after January 1, 1958, if a design change approval for which application is made after...

  10. 14 CFR 26.21 - Limit of validity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... inspection results, of high-time airplanes of similar structural design, accounting for differences in... whether the maximum takeoff gross weight is a result of an original type certificate or a later design... certificate issued after January 1, 1958, if a design change approval for which application is made after...

  11. 14 CFR 26.21 - Limit of validity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... inspection results, of high-time airplanes of similar structural design, accounting for differences in... whether the maximum takeoff gross weight is a result of an original type certificate or a later design... certificate issued after January 1, 1958, if a design change approval for which application is made after...

  12. 14 CFR 26.21 - Limit of validity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... inspection results, of high-time airplanes of similar structural design, accounting for differences in... whether the maximum takeoff gross weight is a result of an original type certificate or a later design... certificate issued after January 1, 1958, if a design change approval for which application is made after...

  13. 7 CFR 868.314 - Grade designation and other certificate information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Milled Rice Principles Governing Application of Standards § 868.314 Grade designation and other certificate information. (a) Milled rice. The grade designation for all classes of Milled rice shall be... Milled rice information. For the class Mixed Milled rice, the following information shall be included in...

  14. 7 CFR 868.211 - Grade designation and other certificate information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Rough Rice Principles Governing Application of Standards § 868.211 Grade designation and other certificate information. (a) Rough rice. The grade designation for all classes of Rough rice shall be included... statement of the milling yield. (b) Mixed rough rice information. For the class Mixed Rough rice, the...

  15. 7 CFR 868.314 - Grade designation and other certificate information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Milled Rice Principles Governing Application of Standards § 868.314 Grade designation and other certificate information. (a) Milled rice. The grade designation for all classes of Milled rice shall be... Milled rice information. For the class Mixed Milled rice, the following information shall be included in...

  16. 7 CFR 868.211 - Grade designation and other certificate information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Rough Rice Principles Governing Application of Standards § 868.211 Grade designation and other certificate information. (a) Rough rice. The grade designation for all classes of Rough rice shall be included... statement of the milling yield. (b) Mixed rough rice information. For the class Mixed Rough rice, the...

  17. 76 FR 6581 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of... design review against explosion risks. During improvement of the protection of fuel pump wiring against...

  18. 76 FR 27242 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes) AGENCY: Federal Aviation... required to conduct a design review against explosion risks. During improvement of the protection of fuel...

  19. Quality assurance and risk management: Perspectives on Human Factors Certification of Advanced Aviation Systems

    NASA Technical Reports Server (NTRS)

    Taylor, Robert M.; Macleod, Iain S.

    1994-01-01

    This paper is based on the experience of engineering psychologists advising the U.K. Ministry of Defense (MoD) on the procurement of advanced aviation systems that conform to good human engineering (HE) practice. Traditional approaches to HE in systems procurement focus on the physical nature of the human-machine interface. Advanced aviation systems present increasingly complex design requirements for human functional integration, information processing, and cognitive task performance effectiveness. These developing requirements present new challenges for HE quality assurance (QA) and risk management, requiring focus on design processes as well as on design content or product. A new approach to the application of HE, recently adopted by NATO, provides more systematic ordering and control of HE processes and activities to meet the challenges of advanced aircrew systems design. This systematic approach to HE has been applied by MoD to the procurement of mission systems for the Royal Navy Merlin helicopter. In MoD procurement, certification is a judicial function, essentially independent of the service customer and industry contractor. Certification decisions are based on advice from MoD's appointed Acceptance Agency. Test and evaluation (T&E) conducted by the contractor and by the Acceptance Agency provide evidence for certification. Certification identifies limitations of systems upon release to the service. Evidence of compliance with HE standards traditionally forms the main basis of HE certification and significant non-compliance could restrict release. The systems HE approach shows concern for the quality of processes as well as for the content of the product. Human factors certification should be concerned with the quality of HE processes as well as products. Certification should require proof of process as well as proof of content and performance. QA criteria such as completeness, consistency, timeliness, and compatibility provide generic guidelines for progressive acceptance and certification of HE processes. Threats to the validity of certification arise from problems and assumptions in T&E methods. T&E should seek to reduce the risk of specification non-compliance and certification failure.

  20. 7 CFR 54.2 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) MEATS, PREPARED MEATS, AND MEAT PRODUCTS (GRADING, CERTIFICATION, AND STANDARDS) Regulations Definitions § 54.2 Designation of...

  1. 7 CFR 54.2 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) MEATS, PREPARED MEATS, AND MEAT PRODUCTS (GRADING, CERTIFICATION, AND STANDARDS) Regulations Definitions § 54.2 Designation of...

  2. Mutational Analysis of the Adaptor Protein 2 Sigma Subunit (AP2S1) Gene: Search for Autosomal Dominant Hypocalcemia Type 3 (ADH3)

    PubMed Central

    Rogers, Angela; Nesbit, M. Andrew; Hannan, Fadil M.; Howles, Sarah A.; Gorvin, Caroline M.; Cranston, Treena; Allgrove, Jeremy; Bevan, John S.; Bano, Gul; Brain, Caroline; Datta, Vipan; Grossman, Ashley B.; Hodgson, Shirley V.; Izatt, Louise; Millar-Jones, Lynne; Pearce, Simon H.; Robertson, Lisa; Selby, Peter L.; Shine, Brian; Snape, Katie; Warner, Justin

    2014-01-01

    Context: Autosomal dominant hypocalcemia (ADH) types 1 and 2 are due to calcium-sensing receptor (CASR) and G-protein subunit-α11 (GNA11) gain-of-function mutations, respectively, whereas CASR and GNA11 loss-of-function mutations result in familial hypocalciuric hypercalcemia (FHH) types 1 and 2, respectively. Loss-of-function mutations of adaptor protein-2 sigma subunit (AP2σ 2), encoded by AP2S1, cause FHH3, and we therefore sought for gain-of-function AP2S1 mutations that may cause an additional form of ADH, which we designated ADH3. Objective: The objective of the study was to investigate the hypothesis that gain-of-function AP2S1 mutations may cause ADH3. Design: The sample size required for the detection of at least one mutation with a greater than 95% likelihood was determined by binomial probability analysis. Nineteen patients (including six familial cases) with hypocalcemia in association with low or normal serum PTH concentrations, consistent with ADH, but who did not have CASR or GNA11 mutations, were ascertained. Leukocyte DNA was used for sequence and copy number variation analysis of AP2S1. Results: Binomial probability analysis, using the assumption that AP2S1 mutations would occur in hypocalcemic patients at a prevalence of 20%, which is observed in FHH patients without CASR or GNA11 mutations, indicated that the likelihood of detecting at least one AP2S1 mutation was greater than 95% and greater than 98% in sample sizes of 14 and 19 hypocalcemic patients, respectively. AP2S1 mutations and copy number variations were not detected in the 19 hypocalcemic patients. Conclusion: The absence of AP2S1 abnormalities in hypocalcemic patients, suggests that ADH3 may not occur or otherwise represents a rare hypocalcemic disorder. PMID:24708097

  3. Advanced Photon Source accelerator ultrahigh vacuum guide

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, C.; Noonan, J.

    1994-03-01

    In this document the authors summarize the following: (1) an overview of basic concepts of ultrahigh vacuum needed for the APS project, (2) a description of vacuum design and calculations for major parts of APS, including linac, linac waveguide, low energy undulator test line, positron accumulator ring (PAR), booster synchrotron ring, storage ring, and insertion devices, and (3) cleaning procedures of ultrahigh vacuum (UHV) components presently used at APS.

  4. Transient analysis of ”2 inch Direct Vessel Injection line break” in SPES-2 facility by using TRACE code

    NASA Astrophysics Data System (ADS)

    D'Amico, S.; Lombardo, C.; Moscato, I.; Polidori, M.; Vella, G.

    2015-11-01

    In the past few decades a lot of theoretical and experimental researches have been done to understand the physical phenomena characterizing nuclear accidents. In particular, after the Three Miles Island accident, several reactors have been designed to handle successfully LOCA events. This paper presents a comparison between experimental and numerical results obtained for the “2 inch Direct Vessel Injection line break” in SPES-2. This facility is an integral test facility built in Piacenza at the SIET laboratories and simulating the primary circuit, the relevant parts of the secondary circuits and the passive safety systems typical of the AP600 nuclear power plant. The numerical analysis here presented was performed by using TRACE and CATHARE thermal-hydraulic codes with the purpose of evaluating their prediction capability. The main results show that the TRACE model well predicts the overall behaviour of the plant during the transient, in particular it is able to simulate the principal thermal-hydraulic phenomena related to all passive safety systems. The performance of the presented CATHARE noding has suggested some possible improvements of the model.

  5. Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition*

    PubMed Central

    Yao, Weilong; Oh, You-Take; Deng, Jiusheng; Yue, Ping; Deng, Liang; Huang, Henry; Zhou, Wei; Sun, Shi-Yong

    2016-01-01

    Death receptor 4 (DR4) is a cell surface receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and triggers apoptosis upon ligation with TRAIL or aggregation. MEK/ERK signaling is a well known and the best-studied effector pathway downstream of Ras and Raf. This study focuses on determining the impact of pharmacological MEK inhibition on DR4 expression and elucidating the underlying mechanism. We found that several MEK inhibitors including MEK162, AZD6244, and PD0325901 effectively decreased DR4 protein levels including cell surface DR4 in different cancer cell lines. Accordingly, pre-treatment of TRAIL-sensitive cancer cell lines with a MEK inhibitor desensitized them to TRAIL-induced apoptosis. These results indicate that MEK inhibition negatively regulates DR4 expression and cell response to TRAIL-induced apoptosis. MEK inhibitors did not alter DR4 protein stability, rather decreased its mRNA levels, suggesting a transcriptional regulation. In contrast, enforced activation of MEK/ERK signaling by expressing ectopic B-Raf (V600E) or constitutively activated MEK1 (MEK1-CA) or MEK2 (MEK2-CA) activated ERK and increased DR4 expression; these effects were inhibited when a MEK inhibitor was present. Promoter analysis through deletion and mutation identified the AP-1 binding site as an essential response element for enhancing DR4 transactivation by MEK1-CA. Furthermore, inhibition of AP-1 by c-Jun knockdown abrogated the ability of MEK1-CA to increase DR4 promoter activity and DR4 expression. These results suggest an essential role of AP-1 in mediating MEK/ERK activation-induced DR4 expression. Our findings together highlight a previously undiscovered mechanism that positively regulates DR4 expression through activation of the MEK/ERK/AP-1 signaling pathway. PMID:27576686

  6. Determination of Heats of Fusion: Using Differential Scanning Calorimetry for the AP Chemistry Courses.

    ERIC Educational Resources Information Center

    Temme, Susan M.

    1995-01-01

    Describes an exercise designed to be used in an Advanced Placement (AP) chemistry course to accompany the study of thermodynamics. Uses Differential Scanning Calorimetry in teaching the concepts of thermochemistry and thermodynamics. (JRH)

  7. Alluvial Diamond Resource Potential and Production Capacity Assessment of Ghana

    USGS Publications Warehouse

    Chirico, Peter G.; Malpeli, Katherine C.; Anum, Solomon; Phillips, Emily C.

    2010-01-01

    In May of 2000, a meeting was convened in Kimberley, South Africa, and attended by representatives of the diamond industry and leaders of African governments to develop a certification process intended to assure that rough, exported diamonds were free of conflictual concerns. This meeting was supported later in 2000 by the United Nations in a resolution adopted by the General Assembly. By 2002, the Kimberley Process Certification Scheme (KPCS) was ratified and signed by both diamond-producing and diamond-importing countries. Over 70 countries were included as members at the end of 2007. To prevent trade in 'conflict' diamonds while protecting legitimate trade, the KPCS requires that each country set up an internal system of controls to prevent conflict diamonds from entering any imported or exported shipments of rough diamonds. Every diamond or diamond shipment must be accompanied by a Kimberley Process (KP) certificate and be contained in tamper-proof packaging. The objective of this study was to assess the alluvial diamond resource endowment and current production capacity of the alluvial diamond-mining sector in Ghana. A modified volume and grade methodology was used to estimate the remaining diamond reserves within the Birim and Bonsa diamond fields. The production capacity of the sector was estimated using a formulaic expression of the number of workers reported in the sector, their productivity, and the average grade of deposits mined. This study estimates that there are approximately 91,600,000 carats of alluvial diamonds remaining in both the Birim and Bonsa diamond fields: 89,000,000 carats in the Birim and 2,600,000 carats in the Bonsa. Production capacity is calculated to be 765,000 carats per year, based on the formula used and available data on the number of workers and worker productivity. Annual production is highly dependent on the international diamond market and prices, the numbers of seasonal workers actively mining in the sector, and environmental conditions, which influence seasonal farming.

  8. 14 CFR 1204.505 - Delegation of authority to execute certificates of full faith and credit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... certificates of full faith and credit. 1204.505 Section 1204.505 Aeronautics and Space NATIONAL AERONAUTICS AND... Delegation of authority to execute certificates of full faith and credit. (a) Scope. This section designates... certificates of full faith and credit (Office of the Administrator section of NASA Form 955) certifying the...

  9. 14 CFR 1204.505 - Delegation of authority to execute certificates of full faith and credit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... certificates of full faith and credit. 1204.505 Section 1204.505 Aeronautics and Space NATIONAL AERONAUTICS AND... Delegation of authority to execute certificates of full faith and credit. (a) Scope. This section designates... certificates of full faith and credit (Office of the Administrator section of NASA Form 955) certifying the...

  10. 14 CFR 1204.505 - Delegation of authority to execute certificates of full faith and credit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... certificates of full faith and credit. 1204.505 Section 1204.505 Aeronautics and Space NATIONAL AERONAUTICS AND... Delegation of authority to execute certificates of full faith and credit. (a) Scope. This section designates... certificates of full faith and credit (Office of the Administrator section of NASA Form 955) certifying the...

  11. Answering the Call of the Web: UVA Crafts a Innovative Web Certification Program for Its Staff.

    ERIC Educational Resources Information Center

    Lee, Sandra T.

    2000-01-01

    Describes the development of a Web Certification Program at the University of Virginia. This program offers certificates at three levels: Web Basics, Web Designer, and Web Master. The paper focuses on: determination of criteria for awarding certificates; program status; program evaluation and program effectiveness; and future plans for the Web…

  12. The Effectiveness of Texas Teacher Certification Programs as Evidenced through Pass Rates on TExES PPR 160 Exam

    ERIC Educational Resources Information Center

    Clouse, Scarlet

    2013-01-01

    The purpose of this study was to investigate the differences between alternative certification pathways, specifically those offered through a university-based, post baccalaureate certification program and a regional education service center certification program. A quantitative research design was implemented and archived scores on the TExES PPR…

  13. 7 CFR 56.2 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) VOLUNTARY GRADING OF SHELL EGGS Grading of Shell Eggs Definitions § 56.2 Designation of official certificates, memoranda, marks...

  14. 14 CFR 21.191 - Experimental certificates.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... aircraft design concepts, new aircraft equipment, new aircraft installations, new aircraft operating... compliance for issuance of type and supplemental type certificates, flights to substantiate major design... from racing events. (f) Market surveys. Use of aircraft for purposes of conducting market surveys...

  15. Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP 3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

    DOE PAGES

    Zhu, Xiaojie; Zhu, Yun; Ye, Sheng; ...

    2015-08-19

    Enfuvirtide (T20), is the first HIV fusion inhibitor approved for treatment of HIV/AIDS patients who fail to respond to the current antiretroviral drugs. However, its clinical application is limited because of short half-life, drug resistance and cross-reactivity with the preexisting antibodies in HIV-infected patients. Using an artificial peptide strategy, we designed a peptide with non-native protein sequence, AP 3, which exhibited potent antiviral activity against a broad spectrum of HIV-1 strains, including those resistant to T20, and had remarkably longer in vivo half-life than T20. While the preexisting antibodies in HIV-infected patients significantly suppressed T20’s antiviral activity, these antibodies neithermore » recognized AP 3, nor attenuated its anti-HIV-1 activity. Structurally different from T20, AP 3 could fold into single-helix and interact with gp41 NHR. The two residues, Met and Thr, at the N-terminus of AP 3 form a hook-like structure to stabilize interaction between AP 3 and NHR helices. Therefore, AP 3 has potential for further development as a new HIV fusion inhibitor with improved antiviral efficacy, resistance profile and pharmacological properties over enfuvirtide. Meanwhile, this study highlighted the advantages of artificially designed peptides, and confirmed that this strategy could be used in developing artificial peptide-based viral fusion inhibitors against HIV and other enveloped viruses.« less

  16. In vivo anteroposterior translation after meniscal-bearing total knee arthroplasty: effects of soft tissue conditions and flexion angle.

    PubMed

    Ishii, Yoshinori; Noguchi, Hideo; Takeda, Mitsuhiro; Sato, Junko; Sakurai, Tetsuya; Toyabe, Shin-Ichi

    2014-08-01

    Anteroposterior (AP) joint translation is an important indicator of good clinical outcome following total knee arthroplasty (TKA). This study evaluated the in vivo relationship between changes in the degree of voluntary soft tissue tension and flexion angle versus simultaneous AP translation after TKA. A posterior cruciate ligament (PCL)-retaining meniscal-bearing design was investigated in 20 knees of 20 patients. AP translation was measured at 30° and 75° flexion with the KT-2000 arthrometer while patients were anesthetized and non-anesthetized. The mean translations at 30° and 75° were 10.5 and 10.4 mm, respectively, in non-anesthetized patients and 13.8 and 12.7 mm, respectively, in patients under anesthesia. AP translation showed a significant positive correlation with soft tissue tension (p < 0.001), but not with flexion angle (p = 0.366). No interaction was observed between soft tissue tension and the flexion angle in terms of AP translation (p = 0.431). Surgeons should recognize that AP translation is greater in anesthetized patients than in non-anesthetized patients, regardless of the flexion angle, with no significant correlation between flexion angle and translation, regardless of the level of consciousness. Because conformity between the tibial insert and femoral component decreases with flexion, whereas the opposing effects of supporting structures, such as muscles, ligaments, and capsules, increases, proper soft tissue tension, particularly retention of a functional PCL, could have an important role in determining AP translation in the current prosthesis design.

  17. Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP 3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhu, Xiaojie; Zhu, Yun; Ye, Sheng

    Enfuvirtide (T20), is the first HIV fusion inhibitor approved for treatment of HIV/AIDS patients who fail to respond to the current antiretroviral drugs. However, its clinical application is limited because of short half-life, drug resistance and cross-reactivity with the preexisting antibodies in HIV-infected patients. Using an artificial peptide strategy, we designed a peptide with non-native protein sequence, AP 3, which exhibited potent antiviral activity against a broad spectrum of HIV-1 strains, including those resistant to T20, and had remarkably longer in vivo half-life than T20. While the preexisting antibodies in HIV-infected patients significantly suppressed T20’s antiviral activity, these antibodies neithermore » recognized AP 3, nor attenuated its anti-HIV-1 activity. Structurally different from T20, AP 3 could fold into single-helix and interact with gp41 NHR. The two residues, Met and Thr, at the N-terminus of AP 3 form a hook-like structure to stabilize interaction between AP 3 and NHR helices. Therefore, AP 3 has potential for further development as a new HIV fusion inhibitor with improved antiviral efficacy, resistance profile and pharmacological properties over enfuvirtide. Meanwhile, this study highlighted the advantages of artificially designed peptides, and confirmed that this strategy could be used in developing artificial peptide-based viral fusion inhibitors against HIV and other enveloped viruses.« less

  18. Certification trails and software design for testability

    NASA Technical Reports Server (NTRS)

    Sullivan, Gregory F.; Wilson, Dwight S.; Masson, Gerald M.

    1993-01-01

    Design techniques which may be applied to make program testing easier were investigated. Methods for modifying a program to generate additional data which we refer to as a certification trail are presented. This additional data is designed to allow the program output to be checked more quickly and effectively. Certification trails were described primarily from a theoretical perspective. A comprehensive attempt to assess experimentally the performance and overall value of the certification trail method is reported. The method was applied to nine fundamental, well-known algorithms for the following problems: convex hull, sorting, huffman tree, shortest path, closest pair, line segment intersection, longest increasing subsequence, skyline, and voronoi diagram. Run-time performance data for each of these problems is given, and selected problems are described in more detail. Our results indicate that there are many cases in which certification trails allow for significantly faster overall program execution time than a 2-version programming approach, and also give further evidence of the breadth of applicability of this method.

  19. Structural Analysis for the American Airlines Flight 587 Accident Investigation: Global Analysis

    NASA Technical Reports Server (NTRS)

    Young, Richard D.; Lovejoy, Andrew E.; Hilburger, Mark W.; Moore, David F.

    2005-01-01

    NASA Langley Research Center (LaRC) supported the National Transportation Safety Board (NTSB) in the American Airlines Flight 587 accident investigation due to LaRC's expertise in high-fidelity structural analysis and testing of composite structures and materials. A Global Analysis Team from LaRC reviewed the manufacturer s design and certification procedures, developed finite element models and conducted structural analyses, and participated jointly with the NTSB and Airbus in subcomponent tests conducted at Airbus in Hamburg, Germany. The Global Analysis Team identified no significant or obvious deficiencies in the Airbus certification and design methods. Analysis results from the LaRC team indicated that the most-likely failure scenario was failure initiation at the right rear main attachment fitting (lug), followed by an unstable progression of failure of all fin-to-fuselage attachments and separation of the VTP from the aircraft. Additionally, analysis results indicated that failure initiates at the final observed maximum fin loading condition in the accident, when the VTP was subjected to loads that were at minimum 1.92 times the design limit load condition for certification. For certification, the VTP is only required to support loads of 1.5 times design limit load without catastrophic failure. The maximum loading during the accident was shown to significantly exceed the certification requirement. Thus, the structure appeared to perform in a manner consistent with its design and certification, and failure is attributed to VTP loads greater than expected.

  20. 14 CFR 145.151 - Personnel requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Personnel § 145.151 Personnel requirements. Each certificated repair station must— (a) Designate a repair station employee as the accountable manager; (b..., preventive maintenance, or alterations performed under the repair station certificate and operations...

  1. 14 CFR 145.151 - Personnel requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Personnel § 145.151 Personnel requirements. Each certificated repair station must— (a) Designate a repair station employee as the accountable manager; (b..., preventive maintenance, or alterations performed under the repair station certificate and operations...

  2. 14 CFR 145.151 - Personnel requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Personnel § 145.151 Personnel requirements. Each certificated repair station must— (a) Designate a repair station employee as the accountable manager; (b..., preventive maintenance, or alterations performed under the repair station certificate and operations...

  3. 14 CFR 21.97 - Approval of major changes in type design.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... must— (1) Provide substantiating data and necessary descriptive data for inclusion in the type design... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Approval of major changes in type design... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Changes to Type Certificates § 21.97...

  4. 49 CFR 107.402 - Application for designation as a certification agency.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... agency. 107.402 Section 107.402 Transportation Other Regulations Relating to Transportation PIPELINE AND... facilities in so far as they relate to the certification activities and will cooperate in the conduct of such... proof that the applicant has: (i) The ability to review and evaluate design drawings, design and stress...

  5. Image sensor with high dynamic range linear output

    NASA Technical Reports Server (NTRS)

    Yadid-Pecht, Orly (Inventor); Fossum, Eric R. (Inventor)

    2007-01-01

    Designs and operational methods to increase the dynamic range of image sensors and APS devices in particular by achieving more than one integration times for each pixel thereof. An APS system with more than one column-parallel signal chains for readout are described for maintaining a high frame rate in readout. Each active pixel is sampled for multiple times during a single frame readout, thus resulting in multiple integration times. The operation methods can also be used to obtain multiple integration times for each pixel with an APS design having a single column-parallel signal chain for readout. Furthermore, analog-to-digital conversion of high speed and high resolution can be implemented.

  6. Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Alvarado, J.; Nemkal, A; Sauder, J

    2009-01-01

    Microsporidia are protists that have been reported to cause infections in both vertebrates and invertebrates. They have emerged as human pathogens particularly in patients that are immunosuppressed and cases of gastrointestinal infection, encephalitis, keratitis, sinusitis, myositis and disseminated infection are well described in the literature. While benzimidazoles are active against many species of microsporidia, these drugs do not have significant activity against Enterocytozoon bieneusi. Fumagillin and its analogues have been demonstrated to have activity in vitro and in animal models of microsporidiosis and human infections due to E. bieneusi. Fumagillin and its analogues inhibit methionine aminopeptidase type 2. Encephalitozoon cuniculimore » MetAP2 (EcMetAP2) was cloned and expressed as an active enzyme using a baculovirus system. The crystal structure of EcMetAP2 was determined with and without the bound inhibitors fumagillin and TNP-470. This structure classifies EcMetAP2 as a member of the MetAP2c family. The EcMetAP2 structure was used to generate a homology model of the E. bieneusi MetAP2. Comparison of microsporidian MetAP2 structures with human MetAP2 provides insights into the design of inhibitors that might exhibit specificity for microsporidian MetAP2.« less

  7. The University of North Carolina Medical Center pharmacy resident leadership certificate program.

    PubMed

    Lyons, Kayley; Griggs, Danielle; Lebovic, Rachel; Roth, Mary E; South, David A; Hatfield, Chad

    2017-03-15

    The development and implementation of a certificate program for pharmacy residents are described. University of North Carolina (UNC) Medical Center met the call for increased efforts in the area of pharmacy residency leadership training through the design, implementation, and evaluation of a leadership certificate program. The purpose of the UNC certificate program is to develop leaders who will serve others, improve their communities, and advance the profession. The program is designed to (1) foster self-awareness, social awareness, and altruism, (2) provide transferable and individualized leadership experiences, (3) enrich other residency components through integration of leadership development opportunities, and (4) create role models for departmental leadership. A team of preceptors and residents implemented the certificate program by integrating program components into the existing pharmacy residency infrastructure. The certificate program includes required and flexible components to allow residents to set and achieve their determined leadership development goals. Overall, residents are satisfied with the program and perceive it as worthwhile. During the first 3 years since implementation of the certification initiative, program facilitators improved the feasibility of, participant engagement in, and sustainability of the program. Future directions include an effectiveness evaluation and a "scale-up" to other institutions. The need for a pharmacy residency leadership certificate was met by designing, implementing, and evaluating such a program at UNC. Through its first 3 years, the program was feasible, sustainable, and valued by program participants. Copyright © 2017 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  8. Developments in Assisting Countries in Implementing the IAEA Additional Protocol

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Killinger, Mark H.; Hansen, Linda H.; Cain, Ronald A.

    In 2008, the U.S. Department of Energy (DOE) began assisting selected non-nuclear weapon states in planning and preparing for implementation of the International Atomic Energy Agency’s Additional Protocol (AP). Since then, the AP international implementation program has contributed to the substantial progress made by Vietnam, Thailand, Iraq, and Malaysia in preparing for entry-into-force of the AP. An overall engagement plan has been developed with components designed to train government AP implementing agencies, inform policy makers, conduct outreach to industry and universities, make AP reporting software available and useful, and plan a detailed approach for implementing the declaration and complementary accessmore » provisions of the AP. DOE recently began collaborating with Indonesia, which has already entered the AP into force, requiring a second method of engagement somewhat different from that taken with countries that have not entered the AP into force. The AP international implementation program, administered by the International Nuclear Safeguards and Engagement Program, is working more closely with DOE’s International Nonproliferation Export Control Program to ensure countries are aware of and prepared to implement the export/import provisions of the AP. As the AP implementation program matures and helps move countries closer to entry-into-force or improved AP implementation, it is identifying characteristics of a country’s “end-state” that indicate that DOE assistance is no longer required. The U.S. AP Implementation Act and Senate Resolution of Ratification require the Administration to report annually to Congress on measures taken to achieve the adoption of the AP in non-nuclear weapon states. DOE’s AP international implementation program is a significant part of these measures. This paper describes recent developments to increase the scope and effectiveness of the program.« less

  9. Isolation and characterization of diadenosine tetraphosphate (Ap4A) hydrolase from Schizosaccharomyces pombe.

    PubMed

    Robinson, A K; de la Peña, C E; Barnes, L D

    1993-02-13

    An enzyme that catalyzes the asymmetric hydrolysis of Ap4A has been partially purified from the fission yeast, Schizosaccharomyces pombe. The crude supernatant fraction from log-phase cells was fractionated by (NH4)2SO4 precipitation followed by chromatography on DEAE-cellulose, Red A dye-ligand and QAE-Sepharose resins. Two peaks of Ap4A hydrolase activity, designated major and minor, were separated on the Red A dye-ligand resin. Both the major and minor Ap4A hydrolase have an apparent molecular mass of 49 kDa based on gel filtration chromatography. On a SDS polyacrylamide gel, a protein of 22 kDa exhibited Ap4A hydrolase activity. Both forms of the enzyme have a Km value in the range of 22 to 36 microM for Ap4A. Both forms of the enzyme asymmetrically hydrolyze Ap4A to AMP and ATP as determined by HPLC. Ap4A is the optimal substrate among several nucleotides and dinucleoside polyphosphates tested at 10 microM. A divalent metal cation is required for activity. Concentrations of Pi below 30 mM stimulate Ap4A hydrolase while higher concentrations inhibit the activity. Pi is not a substrate for this Ap4A-degradative enzyme. Fluoride, from 50 microM to 20 mM, has no significant effect on Ap4A hydrolase activity.

  10. 24 CFR 3282.201 - Scope and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... manufacturers of manufactured homes for sale to purchasers in the United States with respect to certification of manufactured home designs, inspection of designs, quality assurance programs, and manufactured home production... DEVELOPMENT MANUFACTURED HOME PROCEDURAL AND ENFORCEMENT REGULATIONS Manufacturer Inspection and Certification...

  11. 10 CFR 51.55 - Environmental report-standard design certification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Environmental report-standard design certification. 51.55 Section 51.55 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations...

  12. 22 CFR 131.1 - Certification of documents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS CERTIFICATES OF AUTHENTICATION § 131.1 Certification of documents. The Authentication Officer, Acting Authentication Officer, or any Assistant Authentication Officer designated by either of the former officers may, and is hereby authorized to, sign and...

  13. 49 CFR 179.11 - Welding certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Welding certification. 179.11 Section 179.11 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Design Requirements § 179.11 Welding certification. (a) Welding procedures, welders and fabricators shall...

  14. Atmospheric pressure laser desorption/ionization using a 6-7 µm-band mid-infrared tunable laser and liquid water matrix.

    PubMed

    Hiraguchi, Ryuji; Hazama, Hisanao; Masuda, Katsuyoshi; Awazu, Kunio

    2015-01-01

    Due to the characteristic absorption peaks in the IR region, various molecules can be used as a matrix for infrared matrix-assisted laser desorption/ionization (IR-MALDI). Especially in the 6-7 µm-band IR region, solvents used as the mobile phase for liquid chromatography have absorption peaks that correspond to their functional groups, such as O-H, C=O, and CH3. Additionally, atmospheric pressure (AP) IR-MALDI, which is applicable to liquid-state samples, is a promising technique to directly analyze untreated samples. Herein we perform AP-IR-MALDI mass spectrometry of a peptide, angiotensin II, using a mid-IR tunable laser with a tunable wavelength range of 5.50-10.00 µm and several different matrices. The wavelength dependences of the ion signal intensity of [M + H](+) of the peptide are measured using a conventional solid matrix, α-cyano-4-hydroxycinnamic acid (CHCA) and a liquid matrix composed of CHCA and 3-aminoquinoline. Other than the O-H stretching and bending vibration modes, the characteristic absorption peaks are useful for AP-IR-MALDI. Peptide ions are also observed from an aqueous solution of the peptide without an additional matrix, and the highest peak intensity of [M + H](+) is at 6.00 µm, which is somewhat shorter than the absorption peak wavelength of liquid water corresponding to the O-H bending vibration mode. Moreover, long-lasting and stable ion signals are obtained from the aqueous solution. AP-IR-MALDI using a 6-7 µm-band IR tunable laser and solvents as the matrix may provide a novel on-line interface between liquid chromatography and mass spectrometry. Copyright © 2015 John Wiley & Sons, Ltd.

  15. Novel nano-particles as fillers for an experimental resin-based restorative material.

    PubMed

    Rüttermann, S; Wandrey, C; Raab, W H-M; Janda, R

    2008-11-01

    The purpose of this study is to compare the properties of two experimental materials, nano-material (Nano) and Microhybrid, and two trade products, Clearfil AP-X and Filtek Supreme XT. The flexural strength and modulus after 24h water storage and 5000 thermocycles, water sorption, solubility and X-ray opacity were determined according to ISO 4049. The volumetric behavior (DeltaV) after curing and after water storage was investigated with the Archimedes principle. ANOVA was calculated with p<0.05. Clearfil AP-X showed the highest flexural strength (154+/-14 MPa) and flexural modulus (11,600+/-550 MPa) prior to and after thermocycling (117+/-14 MPa and 13,000+/-300 MPa). The flexural strength of all materials decreased after thermocycling, but the flexural modulus decreased only for Filtek Supreme XT. After thermocycling, there were no significant differences in flexural strength and modulus between Filtek Supreme XT, Microhybrid and Nano. Clearfil AP-X had the lowest water sorption (22+/-1.1 microg mm(-3)) and Nano had the highest water sorption (82+/-2.6 microg mm(-3)) and solubility (27+/-2.9 microg mm(-3)) of all the materials. No significant differences occurred between the solubility of Clearfil AP-X, Filtek Supreme XT and Microhybrid. Microhybrid and Nano provided the highest X-ray opacity. Owing to the lower filler content, Nano showed higher shrinkage than the commercial materials. Nano had the highest expansion after water storage. After thermocycling, Nano performed as well as Filtek Supreme XT for flexural strength, even better for X-ray opacity but significantly worse for flexural modulus, water sorption and solubility. The performances of microhybrids were superior to those of the nano-materials.

  16. Program Proposal: Certificates of Competence, Certificate of Achievement, Associate in Applied Science Degree in Sustainable Technology.

    ERIC Educational Resources Information Center

    Pezzoli, Jean A.; Ainsworth, Don

    This document proposes a program in sustainable technology at Maui Community College (Hawaii). This new career program would be designed to provide four Certificates of Competence, a Certificate of Achievement, and an Associate in Applied Science degree. The primary objectives of the program are to meet student, county, and state needs for…

  17. 78 FR 69139 - Physical Security-Design Certification and Operating Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... scheduled to close on October 30, 2013. The Nuclear Energy Institute (NEI) submitted a letter on October 9... NUCLEAR REGULATORY COMMISSION [NRC-2013-0225] Physical Security--Design Certification and Operating Reactors AGENCY: Nuclear Regulatory Commission. ACTION: Standard review plan--draft section...

  18. 75 FR 1831 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP1000...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ...-3, 2010, 11545 Rockville Pike, Room T2-B1, Rockville, Maryland. The meeting will be open to public... the Draft Safety Evaluation Report associated with the amendment to the Westinghouse AP1000 Design...

  19. 75 FR 74103 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on AP1000...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... Impact Assessment for the proposed AP1000 design. The Subcommittee will hear presentations by and hold... be obtained from the website cited above or by contacting the identified DFO. Moreover, in view of...

  20. PVDaCS - A prototype knowledge-based expert system for certification of spacecraft data

    NASA Technical Reports Server (NTRS)

    Wharton, Cathleen; Shiroma, Patricia J.; Simmons, Karen E.

    1989-01-01

    On-line data management techniques to certify spacecraft information are mandated by increasing telemetry rates. Knowledge-based expert systems offer the ability to certify data electronically without the need for time-consuming human interaction. Issues of automatic certification are explored by designing a knowledge-based expert system to certify data from a scientific instrument, the Orbiter Ultraviolet Spectrometer, on an operating NASA planetary spacecraft, Pioneer Venus. The resulting rule-based system, called PVDaCS (Pioneer Venus Data Certification System), is a functional prototype demonstrating the concepts of a larger system design. A key element of the system design is the representation of an expert's knowledge through the usage of well ordered sequences. PVDaCS produces a certification value derived from expert knowledge and an analysis of the instrument's operation. Results of system performance are presented.

  1. 5 CFR 2634.1005 - How to obtain a Certificate of Divestiture.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Divestiture. 2634.1005 Section 2634.1005 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS EXECUTIVE BRANCH FINANCIAL DISCLOSURE, QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE... the designated agency ethics official. An employee seeking a Certificate of Divestiture must submit a...

  2. 48 CFR 252.225-7020 - Trade Agreements Certificate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Trade Agreements... of Provisions And Clauses 252.225-7020 Trade Agreements Certificate. As prescribed in 225.1101(5), use the following provision: Trade Agreements Certificate (JAN 2005) (a) Definitions. Designated...

  3. 19 CFR 115.10 - Certificate of approval.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS... design type for a specified number or unlimited series of containers that are approved in accordance with..., 1975. (b) Containers—(1) Approval after manufacture. A Certifying Authority shall issue a certificate...

  4. 19 CFR 115.10 - Certificate of approval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS... design type for a specified number or unlimited series of containers that are approved in accordance with..., 1975. (b) Containers—(1) Approval after manufacture. A Certifying Authority shall issue a certificate...

  5. 19 CFR 115.10 - Certificate of approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS... design type for a specified number or unlimited series of containers that are approved in accordance with..., 1975. (b) Containers—(1) Approval after manufacture. A Certifying Authority shall issue a certificate...

  6. 19 CFR 115.10 - Certificate of approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS... design type for a specified number or unlimited series of containers that are approved in accordance with..., 1975. (b) Containers—(1) Approval after manufacture. A Certifying Authority shall issue a certificate...

  7. 19 CFR 115.10 - Certificate of approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS... design type for a specified number or unlimited series of containers that are approved in accordance with..., 1975. (b) Containers—(1) Approval after manufacture. A Certifying Authority shall issue a certificate...

  8. 23 CFR 669.11 - Certification submittal.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Certification submittal. 669.11 Section 669.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS ENFORCEMENT OF HEAVY VEHICLE USE TAX § 669.11 Certification submittal. The Governor or an official designated...

  9. 10 CFR Appendix A to Part 52 - Design Certification Rule for the U.S. Advanced Boiling Water Reactor

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Water Reactor A Appendix A to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES... Rule for the U.S. Advanced Boiling Water Reactor I. Introduction Appendix A constitutes the standard design certification for the U.S. Advanced Boiling Water Reactor (ABWR) design, in accordance with 10 CFR...

  10. 10 CFR Appendix A to Part 52 - Design Certification Rule for the U.S. Advanced Boiling Water Reactor

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Water Reactor A Appendix A to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES... Rule for the U.S. Advanced Boiling Water Reactor I. Introduction Appendix A constitutes the standard design certification for the U.S. Advanced Boiling Water Reactor (ABWR) design, in accordance with 10 CFR...

  11. Quality Certification, Institutions and Innovation in Local Agro-Food Systems: Protected Designations of Origin of Olive Oil in Spain

    ERIC Educational Resources Information Center

    Canada, Javier Sanz; Vazquez, Alfredo Macias

    2005-01-01

    This article examines the interrelations between establishment of territorial quality certification systems (Protected Designations of Origin or PDOs), diffusion of innovations through local agro-food chains, and the role of the institutions overseeing geographical designations. Empirical analysis is applied to olive oil PDOs in Spain and entails…

  12. Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity.

    PubMed

    Li, Jing-Ya; Cui, Yong-Mei; Chen, Ling-Ling; Gu, Min; Li, Jia; Nan, Fa-Jun; Ye, Qi-Zhuang

    2004-05-14

    Methionine aminopeptidase (MetAP) catalyzes the removal of methionine from newly synthesized polypeptides. MetAP carries out this cleavage with high precision, and Met is the only natural amino acid residue at the N terminus that is accepted, although type I and type II MetAPs use two different sets of residues to form the hydrophobic S1 site. Characteristics of the S1 binding pocket in type I MetAP were investigated by systematic mutation of each of the seven S1 residues in Escherichia coli MetAP type I (EcMetAP1) and human MetAP type I (HsMetAP1). We found that Tyr-65 and Trp-221 in EcMetAP1, as well as the corresponding residues Phe-197 and Trp-352 in HsMetAP1, were essential for the hydrolysis of a thiopeptolide substrate, Met-S-Gly-Phe. Mutation of Phe-191 to Ala in HsMetAP1 caused inactivity in contrast to the full activity of EcMetAP1(Y62A), which may suggest a subtle difference between the two type I enzymes. The more striking finding is that mutation of Cys-70 in EcMetAP1 or Cys-202 in HsMetAP1 opens up the S1 pocket. The thiopeptolides Leu-S-Gly-Phe and Phe-S-Gly-Phe, with previously unacceptable Leu or Phe as the N-terminal residue, became efficient substrates of EcMetAP1(C70A) and HsMetAP1(C202A). The relaxed specificity shown in these S1 site mutants for the N-terminal residues was confirmed by hydrolysis of peptide substrates and inhibition by reaction products. The structural features at the enzyme active site will be useful information for designing specific MetAP inhibitors for therapeutic applications.

  13. Design Study of an MBA Lattice for the Advanced Photon Source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Decker, Glenn

    2014-11-02

    Recent interest in ultra-low-emittance designs for storage-ring-based synchrotron light sources has spurred a focused design effort on a multi-bend achromat (MBA) storage ring replacement for the Advanced Photon Source (APS). The APS is relatively large (1104 m circumference) and, as such, an upgrade to a fourth-generation storage ring holds the potential for a two to three order of magnitude enhancement of X-ray brightness due to the approximate inverse cubic scaling of emittance with the number of dipole bend magnets.

  14. Analogue patients' self-reported engagement and psychophysiological arousal in a video-vignettes design: Patients versus disease-naïve individuals.

    PubMed

    Visser, Leonie N C; Tollenaar, Marieke S; Bosch, Jos A; van Doornen, Lorenz J P; de Haes, Hanneke C J M; Smets, Ellen M A

    2016-10-01

    The ecological validity of video-vignettes design investigating patient-provider communication hinges on the engagement of analogue patients (APs) with the vignette. The present study aimed to compare engagement in two commonly utilized groups of APs, patients and disease-naïve individuals. Engagement was assessed by self-report and in the form of physiological arousal. Cancer patients (N=22) and disease-naïve individuals (N=24) were recruited as APs. APs completed the Video Engagement Scale after watching a vignette of a oncologic bad news consultation. Electrodermal and cardiovascular activity were assessed continuously during watching the vignette, and cortisol levels were assessed in four saliva samples. Patients reported higher engagement with the vignette than disease-naïve individuals (t=2.46, p<0.05) and showed a larger blood pressure response (systolic: F=5.87, p<0.01 and diastolic: F=4.00, p<0.05). However, these differences disappeared after adjusting for age. No group differences were found on other psychophysiological parameters. Our results suggest that patients and disease-naïve individuals are equally engaged when viewing video vignettes. When group differences were found, older age turned out to be a more prominent predictor of engagement. Researchers may consider other arguments besides APs' disease history when selecting an AP group. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1.

    PubMed

    Cheruvallath, Zacharia; Tang, Mingnam; McBride, Christopher; Komandla, Mallareddy; Miura, Joanne; Ton-Nu, Thu; Erikson, Phil; Feng, Jun; Farrell, Pamela; Lawson, J David; Vanderpool, Darin; Wu, Yiqin; Dougan, Douglas R; Plonowski, Artur; Holub, Corine; Larson, Chris

    2016-06-15

    Methionine aminopeptidase 2 (MetAP2) is an enzyme that cleaves an N-terminal methionine residue from a number of newly synthesized proteins. Pre-clinical and clinical studies suggest that MetAP2 inhibitors could be used as a novel treatment for obesity. Herein we describe our use of fragment screening methods and structural biology to quickly identify and elaborate an indazole fragment into a series of reversible MetAP2 inhibitors with <10nM potency, excellent selectivity, and favorable in vitro safety profiles. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Interleaving lattice for the Argonne Advanced Photon Source linac

    NASA Astrophysics Data System (ADS)

    Shin, S.; Sun, Y.; Dooling, J.; Borland, M.; Zholents, A.

    2018-06-01

    To realize and test advanced accelerator concepts and hardware, a beam line is being reconfigured in the linac extension area (LEA) of the Argonne Advanced Photon Source (APS) linac. A photocathode rf gun installed at the beginning of the APS linac will provide a low emittance electron beam into the LEA beam line. The thermionic rf gun beam for the APS storage ring and the photocathode rf gun beam for the LEA beam line will be accelerated through the linac in an interleaved fashion. In this paper, the design studies for interleaving lattice realization in the APS linac is described with the initial experiment result.

  17. Alternate Lattice Design for Advanced Photon Source Multi-Bend Achromat Upgrade

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sun, Yipeng; Borland, Michael

    2015-01-01

    A 67-pm hybrid-seven-bend achromat (H7BA) lattice is proposed for a futureAdvanced Photon Source (APS)multibend- achromat (MBA) upgrade. This lattice requires use of a swap-out (on-axis) injection scheme. Alternate lattice design work has also been performed to achieve better beam dynamics performance than the nominal APS MBA lattice, in order to allow beam accumulation. One of such alternate H7BA lattice designs, which still targets a very low emittance of 76 pm, is discussed in this paper. With these lattices, existing APS injector complex can be employed without the requirement of a very high charge operation. Studies show that an emittance belowmore » 76 pm can be achieved with the employment of reverse bends in an alternate lattice. We discuss the predicted performance and requirements for these lattices and compare them to the nominal lattice.« less

  18. Removal of arsenic in flotation of galena and sphalerite

    NASA Astrophysics Data System (ADS)

    Yu, Dae-hwan; Kim, Min-kyu; Han, Oh-hyung; Park, Chul-hyun

    2017-04-01

    In Korea, Janggun mine that produces the concentrate of galena (PbS) /sphalerite (ZnS) containing arsenic of 1.3% charges a penalty of US 3/ton to LS-Nikko smelter. Hence in this work, flotation tests for removal of arsenopyrite (FeAsS) from sulfide minerals were carried out using lab scale flotation cell, which maintain grade and recovery of PbS and ZnS in comparison to flotation plant. Particularly, this study was focused on investigating the combination of several chemical reagents such as depressant, collector, activator and etc. that affect flotation performance. In the straight differential flotation for PbS, a PbS grade of 67.80% and a recovery of 80.2% could be obtained with FeAsS removal of 84.1% (0.2% As) under the conditions of 20% feed solids concentration, pH 8.5, 50g/t frother (AF65), 50g/t collector (AP242) and 600g/t As depressant (NaHSO3) and 600g/t Zn depressant (ZnSO4). In the ZnS flotation, the maximum separation achievable for ZnS has been shown to be a grade of 50.27% and a recovery of 88.7%. At this time, FeAsS removal of 87.8% (0.16% As) could be successfully accomplished under pH 11, and 1.2kg/t Zn activator (CuSO4), 100g/t frother (AF65), 100g/t collector (AP211) and 400g/t As depressant (NaHSO3). Acknowledgments This work was supported by the Energy and Resources Engineering Program Grant funded by the Ministry of Trade, Industry and Energy, Korea

  19. Measurement of the atmospheric aerosol particle size distribution in a highly polluted mega-city in Southeast Asia (Dhaka-Bangladesh)

    NASA Astrophysics Data System (ADS)

    Salam, Abdus; Mamoon, Hassan Al; Ullah, Md. Basir; Ullah, Shah M.

    2012-11-01

    Aerosol particle size distribution was measured with an aerodynamic particle sizer (APS) spectrometer continuously from January 21 to April 24, 2006 in Dhaka, Bangladesh. Particles number, surface and mass distributions data were stored automatically with Aerosol Instrument Manager (AIM) software on average every half an hour in a computer attached to the APS. The grand total average of number, surface and mass concentrations were 8.2 × 103 ± 7.8 × 103 particles cm-3, 13.3 × 103 ± 11.8 × 103 μm2 cm-3 and 3.04 ± 2.10 mg m-3, respectively. Fine particles with diameter smaller than 1.0 μm aerodynamic diameter (AD) dominated the number concentration, accounted for 91.7% of the total particles indicating vehicular emissions were dominating in Dhaka air either from fossil fuel burning or compressed natural gas (CNGs). The surface and mass concentrations between 0.5 and 1.0 μm AD were about 56.0% and 26.4% of the total particles, respectively. Remarkable seasonal differences were observed between winter and pre-monsoon seasons with the highest monthly average in January and the lowest in April. Aerosol particles in winter were 3.79 times higher for number, 3.15 times for surface and 2.18 times for mass distributions than during the pre-monsoon season. Weekends had lower concentrations than weekdays due to less vehicular traffic in the streets. Aerosol particles concentrations were about 15.0% (ranging from 9.4% to 17.3%) higher during traffic peak hours (6:00am-8:00pm) than off hours (8:00pm-6:00am). These are the first aerosol size distribution measurements with respect to number, surface and mass concentrations in real time at Dhaka, Bangladesh.

  20. 76 FR 64788 - Airworthiness Directives; BAE SYSTEMS (Operations) Limited Model 4101 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... ``Certification Maintenance Requirements'', and, --05-10-30 ``Critical Design Configuration Control Limitations... Limitations''; 05-10-20, ``Certification Maintenance Requirements''; and 05-10-30, ``Critical Design... BAE Systems (Operations) Limited Jetstream Series 4100 AMM, Revision 35, dated February 15, 2011. We...

  1. 24 CFR 3286.111 - Installer certification of installation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... manufactured home has been installed in accordance with: (i) An installation design and instructions that have... HOUSING AND URBAN DEVELOPMENT MANUFACTURED HOME INSTALLATION PROGRAM Certification of Installation in HUD...; or (ii) An installation design and instructions that have been prepared and certified by a...

  2. 75 FR 58016 - Consensus Standards, Standard Practice for Design, Alteration, and Certification of Airplane...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Consensus Standards, Standard... announces the availability of consensus standards and the Federal Aviation Administration (FAA) intention to accept the ASTM International's F2639-07 Standard Practice for Design, Alteration, and Certification of...

  3. 77 FR 70176 - Previous Participation Certification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ... percent automated and digital submission of all data and certifications is available via HUD's secure... information is designed to be 100 percent automated and digital submission of all data and certifications is available via HUD's secure Internet systems. However HUD will provide for both electronic and paper...

  4. 5 CFR 1330.403 - System certification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false System certification. 1330.403 Section....403 System certification. (a) The performance appraisal system(s) covering senior employees must be... certify an agency's appraisal system(s) only when a review of that system's design, application, and...

  5. 5 CFR 1330.403 - System certification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false System certification. 1330.403 Section....403 System certification. (a) The performance appraisal system(s) covering senior employees must be... certify an agency's appraisal system(s) only when a review of that system's design, application, and...

  6. 48 CFR 252.225-7020 - Trade Agreements Certificate.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Trade Agreements... of Provisions And Clauses 252.225-7020 Trade Agreements Certificate. As prescribed in 225.1101(5)(i), use the following provision: Trade Agreements Certificate (JAN 2005) (a) Definitions. Designated...

  7. Developing an Online Certification Program for Nutrition Education Assistants

    ERIC Educational Resources Information Center

    Christofferson, Debra; Christensen, Nedra; LeBlanc, Heidi; Bunch, Megan

    2012-01-01

    Objective: To develop an online certification program for nutrition education paraprofessionals to increase knowledge and confidence and to overcome training barriers of programming time and travel expenses. Design: An online interactive certification course based on Supplemental Nutrition Assistance Program-Education and Expanded Food and…

  8. 7 CFR 1724.32 - Inspection and certification of work order construction.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES Engineering Services § 1724.32 Inspection and certification of work order... accordance with acceptable engineering practice. (2) A certification must also include the name of the...

  9. 7 CFR 1724.32 - Inspection and certification of work order construction.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES Engineering Services § 1724.32 Inspection and certification of work order... accordance with acceptable engineering practice. (2) A certification must also include the name of the...

  10. 7 CFR 1724.32 - Inspection and certification of work order construction.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES Engineering Services § 1724.32 Inspection and certification of work order... accordance with acceptable engineering practice. (2) A certification must also include the name of the...

  11. Nuclear Reactor Safety--The APS Submits its Report

    ERIC Educational Resources Information Center

    Physics Today, 1975

    1975-01-01

    Presents the summary section of the American Physical Society (APS) report on the safety features of the light-water reactor, reviews the design, construction, and operation of a reactor and outlines the primary engineered safety features. Summarizes the major recommendations of the study group. (GS)

  12. 76 FR 68675 - Revisions to the Export Administration Regulations (EAR): Control of Aircraft and Related Items...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ...(g) of the July 15 proposed rule) and all other 600 series items if, at the time of export, reexport... designed'' for a defense article would become subject to the new 600 series controls on the CCL as... the extent an item is ``specially designed'' for a military use, it is subject to a 600 series ECCN in...

  13. [Effectiveness of a self-management program using goal setting based on a G-AP for patients after a stroke].

    PubMed

    Park, Min Gyeong; Ha, Yeongmi

    2014-10-01

    This study was conducted to develop a self-management program using goal setting for patients after a stroke. The program was based on a theory-based Goal setting and Action Planning framework (G-AP), and the effectiveness of the program was examined. A non-equivalent control group pretest-posttest design was used. The experimental group (n=30) received the self-management program using goal setting based on the G-AP over 7 weeks. The education was delivered individually with a specifically designed stroke workbook. The control group (n=30) received only patient information leaflets about stroke. There were significant differences between the two groups. Stroke knowledge, self-efficacy, and health behavior compliance were significantly higher (all p<.001), and hospital anxiety (p<.001) and depression (p<.001) were significantly lower in the experimental group compared to the control group. This self-management program using goal setting based on a G-AP was found to be useful and beneficial for patients in stroke rehabilitation settings.

  14. Spectral characteristics of geomagnetic field variations at low and equatorial latitudes

    USGS Publications Warehouse

    Campbell, W.H.

    1977-01-01

    Geomagnetic field spectra from eight standard observations at geomagnetic latitudes below 30?? were studied to determine the field characteristics unique to the equatorial region. Emphasis was placed upon those variations having periods between 5 min and 4 hr for a selection of magnetically quiet, average, and active days in 1965. The power spectral density at the equator was about ten times that the near 30?? latitude. The initial manifestation of the equatorial electrojet as evidenced by the east-west alignment of the horizontal field or the change in vertical amplitudes occurred below about 20?? latitude. Induced current effects upon the vertical component from which the Earth conductivity might be inferred could best be obtained at times and latitudes unaffected by the electrojet current. Values of about 1.6 ?? 103 mhos/m for an effective skin depth of 500-600 km were determined. The spectral amplitudes increased linearly with geomagnetic activity index, Ap. The spectral slope had a similar behavior at all latitudes. The slope changed systematically with Ap-index and showed a diurnal variation, centered on local noon, that changed form with geomagnetic activity.

  15. Chromosome localization of human genes for clathrin adaptor polypeptides AP2{beta} and AP50 and the clathrin-binding protein, VCP

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Druck, T.; Gu, Y.; Prabhala, G.

    1995-11-01

    Clathrin-coated vesicles, involved in endocytosis and Golgi processing, have a surface lattice containing clathrin triskelia and stoichiometric amounts of additional components termed {open_quotes}assembly proteins,{close_quotes} or APs. The AP form at the plasma membrane, AP2, is composed of two large subunits of 100-115 kDa, denoted AP2{alpha} and AP2{beta}, a medium chain of 50 kDa, designated AP50, and a small chain. We have determined human chromosomal locations of genes for a large AP2{beta} (CLAPB1) and a medium (CLAPM1) AP subunit and of a novel clathrin-binding protein, VCP, that binds clathrin simultaneously with A1`s. Chromosomal in situ hybridization of a human genomic clonemore » demonstrated that the CLAPM1 gene mapped to chromosome region 3q28. The gene for the CLAPB1 large subunit was mapped to 17q11.2-q12 by PCR amplification of an AP2{beta} fragment from a panel of rodent-human hybrid DNAs. To map the human VCP sequence, a human-specific probe was made by RT-PCR of human mRNA using oligonucleotide primers from conserved regions of the porcine sequence. The amplified human fragment served as probe on Southern blots of hybrid DNAs to determine that the human VCP locus maps to chromosome region 9pter-q34. 13 refs., 2 figs.« less

  16. 24 CFR 3280.510 - Heat loss certificate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Heat loss certificate. 3280.510... URBAN DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS Thermal Protection § 3280.510 Heat... specify the following: (a) Heating zone certification. The design zone at which the manufactured home heat...

  17. 24 CFR 3280.510 - Heat loss certificate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Heat loss certificate. 3280.510... URBAN DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS Thermal Protection § 3280.510 Heat... specify the following: (a) Heating zone certification. The design zone at which the manufactured home heat...

  18. 24 CFR 3280.510 - Heat loss certificate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Heat loss certificate. 3280.510... URBAN DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS Thermal Protection § 3280.510 Heat... specify the following: (a) Heating zone certification. The design zone at which the manufactured home heat...

  19. 24 CFR 3280.510 - Heat loss certificate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Heat loss certificate. 3280.510... URBAN DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS Thermal Protection § 3280.510 Heat... specify the following: (a) Heating zone certification. The design zone at which the manufactured home heat...

  20. 24 CFR 3280.510 - Heat loss certificate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Heat loss certificate. 3280.510... URBAN DEVELOPMENT MANUFACTURED HOME CONSTRUCTION AND SAFETY STANDARDS Thermal Protection § 3280.510 Heat... specify the following: (a) Heating zone certification. The design zone at which the manufactured home heat...

  1. 26 CFR 54.9801-5 - Evidence of creditable coverage.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... reasonable and prompt fashion, can provide the certificate. A certificate is required to be provided under... the plan, acting in a reasonable and prompt fashion, can provide certificates. (ii) Conclusion. In... Secretary to establish rules designed to prevent an individual's subsequent coverage under a group health...

  2. Mentoring Alternative Certification Teachers: Implementing an Online Collaborative Consultation Community

    ERIC Educational Resources Information Center

    Dukes, Lyman, III; Jones, Brett D.

    2007-01-01

    Online discussion boards have the potential to provide significant support to beginning teachers; thus, we designed an online collaborative consultation community to provide mentor support to university students enrolled in an alternative certification program. The results suggest that although students in alternative certification programs will…

  3. Building Intercultural Competence through Intercultural Competency Certification of Undergraduate Students

    ERIC Educational Resources Information Center

    Janeiro, Maria G. Fabregas; Fabre, Ricardo Lopez; Nuno de la Parra, Jose Pablo

    2014-01-01

    The Intercultural Competency Certificate (CCI in Spanish) designed for the Universidad Popular Autonoma del Estado de Puebla (UPAEP University) is a theory based comprehensive plan to develop undergraduate students' intercultural competence. This Certificate is based in the Developmental Model of Intercultural Sensitivity (DMIS) developed by…

  4. 49 CFR 240.105 - Criteria for selection of designated supervisors of locomotive engineers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of locomotive engineers. 240.105 Section 240.105 Transportation Other Regulations Relating to... CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.105 Criteria for selection of designated supervisors of locomotive engineers. (a) Each railroad's program shall include...

  5. 49 CFR 240.105 - Criteria for selection of designated supervisors of locomotive engineers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of locomotive engineers. 240.105 Section 240.105 Transportation Other Regulations Relating to... CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.105 Criteria for selection of designated supervisors of locomotive engineers. (a) Each railroad's program shall include...

  6. 49 CFR 240.105 - Criteria for selection of designated supervisors of locomotive engineers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of locomotive engineers. 240.105 Section 240.105 Transportation Other Regulations Relating to... CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.105 Criteria for selection of designated supervisors of locomotive engineers. (a) Each railroad's program shall include...

  7. 49 CFR 240.105 - Criteria for selection of designated supervisors of locomotive engineers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of locomotive engineers. 240.105 Section 240.105 Transportation Other Regulations Relating to... CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.105 Criteria for selection of designated supervisors of locomotive engineers. (a) Each railroad's program shall include...

  8. In vitro and in vivo antioxidant potential of milks, yoghurts, fermented milks and cheeses: a narrative review of evidence.

    PubMed

    Fardet, Anthony; Rock, Edmond

    2018-06-01

    The antioxidant potential (AP) is an important nutritional property of foods, as increased oxidative stress is involved in most diet-related chronic diseases. In dairy products, the protein fraction contains antioxidant activity, especially casein. Other antioxidants include: antioxidant enzymes; lactoferrin; conjugated linoleic acid; coenzyme Q10; vitamins C, E, A and D3; equol; uric acid; carotenoids; and mineral activators of antioxidant enzymes. The AP of dairy products has been extensively studied in vitro, with few studies in animals and human subjects. Available in vivo studies greatly differ in their design and objectives. Overall, on a 100 g fresh weight-basis, AP of dairy products is close to that of grain-based foods and vegetable or fruit juices. Among dairy products, cheeses present the highest AP due to their higher protein content. AP of milk increases during digestion by up to 2·5 times because of released antioxidant peptides. AP of casein is linked to specific amino acids, whereas β-lactoglobulin thiol groups play a major role in the AP of whey. Thermal treatments such as ultra-high temperature processing have no clear effect on the AP of milk. Raw fat-rich milks have higher AP than less fat-rich milk, because of lipophilic antioxidants. Probiotic yoghurts and fermented milks have higher AP than conventional yoghurt and milk because proteolysis by probiotics releases antioxidant peptides. Among the probiotics, Lactobacillus casei/acidophilus leads to the highest AP. The data are insufficient for cheese, but fermentation-based changes appear to make a positive impact on AP. In conclusion, AP might participate in the reported dairy product-protective effects against some chronic diseases.

  9. How field monitoring of green infrastructure stormwater practices has led to changes in North Carolina's Stormwater BMP design manual

    NASA Astrophysics Data System (ADS)

    Hunt, W. F.; Winston, R. J.

    2011-12-01

    Green Infrastructure stormwater management is comprised of many biologically-based stormwater treatment practices. Two of which, bioretention and level spreader- vegetative filter strips, have been extensively studied at over 10 different field locations across North Carolina by NC State University. The result of this research has been dramatic changes to the state of North Carolina's stormwater BMP Design Manual, which now allows a greater amount of flexibility for the design of each practice than most other design manuals. The purpose of this presentation is to present a summary of research conducted in North Carolina and associate that research with specific changes made in the state's design guidance for both bioretention (Table 1) and level spreader- vegetated filter strip systems (Table 2). Among the changes are type of vegetation, ratio of hydraulic loading, underdrainage configuration, and fill media selection. References (in print) associated with the tables are listed below: Hathaway, J.M. and W.F. Hunt. 2008. Field Evaluation of Level Spreaders in the Piedmont of North Carolina. Journal of Irrigation and Drainage Engineering, 134(4):538-542. Hunt, W.F., A.R. Jarrett, J.T. Smith, L.J. Sharkey. 2006. Evaluating Bioretention Hydrology and Nutrient Removal at Three Field Sites in North Carolina. Journal of Irrigation and Drainage Engineering, 132 (6): 600-608. Hunt, W.F., J.M. Hathaway, R.J. Winston, and S.J. Jadlocki. 2010. Runoff Volume Reduction by a Level Spreader - Vegetated Filter Strip System in Suburban Charlotte, NC. Journal of Hydrologic Engineering, 15(6): 399-503. Jones, M.P. and W.F. Hunt. 2009. Bioretention Impact on Runoff Temperature in Trout Sensitive Waters. Journal of Environmental Engineering, 135(8): 577-585. Li, H., L.J. Sharkey, W.F. Hunt, A.P. Davis. 2009. Mitigation of Impervious Surface Hydrology using Bioretention in North Carolina and Maryland. Journal of Hydrologic Engineering, 14(4): 407-415. Line, D.E. and W.F. Hunt. 2009. Performance of a Bioretention Area and a Level Spreader-Grass Filter Strip at Two Highway Sites in North Carolina. Journal of Irrigation and Drainage Engineering, 135(2): 217-224. Passeport, E., W.F. Hunt, D.E. Line, R.A. Smith, and R.A. Brown. 2009. Field Study of the Ability of Two Grassed Bioretention Cells to Reduce Stormwater Runoff Pollution. Journal of Irrigation and Drainage Engineering, 135(4): 505-510. Winston, R.J., W.F. Hunt, D.L. Osmond, W.G. Lord, and M.D. Woodward. 2011. Field Evaluation of Four Level Spreader - Vegetative Filter Strips to Improve Urban Stormwater Quality. Journal of Irrigation and Drainage Engineering. 137(3): 170-182.
    Table 1 - Research-Based Design Changes for Bioretention in North Carolina Table 2 - Level Spreader - Vegetated Filter Strip Design Evolution in North Carolina

  10. 43 CFR 426.12 - Excess land.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... certification or reporting forms; or (2) If a landowner fails to designate his or her land as excess or nonexcess on the appropriate certification or reporting forms: (i) And all of the landowner's nonexempt land... certification or reporting forms within 30-calendar days of the notification; (2) If the landowner fails to make...

  11. 43 CFR 426.12 - Excess land.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... certification or reporting forms; or (2) If a landowner fails to designate his or her land as excess or nonexcess on the appropriate certification or reporting forms: (i) And all of the landowner's nonexempt land... certification or reporting forms within 30-calendar days of the notification; (2) If the landowner fails to make...

  12. The Florida State Initial Teacher Certification Test: A Case Study.

    ERIC Educational Resources Information Center

    Dorn, Charles M.

    1989-01-01

    Describes the development of the art certification examination which was designed for the Florida State Initial Teacher Certification Test. Discusses problems of subjectivity, content, and question format. Suggests criteria which can guide the development of viable college art education programs that can adequately prepare teachers in the areas of…

  13. 31 CFR 321.19 - Certification of signatures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Certification of signatures. 321.19... From Erroneous Payments § 321.19 Certification of signatures. The regulations in this subpart shall, to... signatures by an officer or designated employee of any financial institution authorized to certify requests...

  14. 24 CFR 598.210 - What certifications must governments make?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... governments make? 598.210 Section 598.210 Housing and Urban Development Regulations Relating to Housing and... DESIGNATIONS Nomination Procedure § 598.210 What certifications must governments make? Certifications must be... urban area satisfies the boundary tests of § 598.100(d); (b) The nominated urban area is one of...

  15. 24 CFR 598.210 - What certifications must governments make?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... make? 598.210 Section 598.210 Housing and Urban Development Regulations Relating to Housing and Urban... DESIGNATIONS Nomination Procedure § 598.210 What certifications must governments make? Certifications must be... urban area satisfies the boundary tests of § 598.100(d); (b) The nominated urban area is one of...

  16. 46 CFR 153.812 - Inspection for Certificate of Inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Inspection for Certificate of Inspection. 153.812... CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Testing and Inspection § 153.812 Inspection for Certificate of Inspection. The rules governing the...

  17. 15 CFR 280.323 - Transfer or assignment of the trademark registration or recorded insignia.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF... trademark application or registration which forms the basis of a certificate of recordal, the Director, USPTO, shall designate the certificate of recordal as inactive. The certificate of recordal shall be...

  18. 15 CFR 280.323 - Transfer or assignment of the trademark registration or recorded insignia.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF... trademark application or registration which forms the basis of a certificate of recordal, the Director, USPTO, shall designate the certificate of recordal as inactive. The certificate of recordal shall be...

  19. 46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....205 Section 169.205 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... school vessel or an application for designation, as set forth in § 169.218; and (3) Information...

  20. 46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ....205 Section 169.205 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... school vessel or an application for designation, as set forth in § 169.218; and (3) Information...

  1. 46 CFR 169.205 - Obtaining or renewing a Certificate of Inspection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ....205 Section 169.205 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.205 Obtaining or... school vessel or an application for designation, as set forth in § 169.218; and (3) Information...

  2. Achieving and Maintaining Existing Building Sustainability Certification at Georgetown University

    ERIC Educational Resources Information Center

    Payant, Richard P.

    2013-01-01

    Sustainability is the promotion of high performance, healthful, energy-efficient, and environmentally stable buildings. Buildings intended for sustainable certification must meet guidelines developed by the Leadership in Energy and Environmental Design (LEED) of the U.S. Green Building Council. The problem is that LEED certification often fails to…

  3. 29 CFR 2590.701-5 - Evidence of creditable coverage.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in a reasonable and prompt fashion, can provide the certificate. A certificate is required to be... earliest date that the plan, acting in a reasonable and prompt fashion, can provide certificates. (ii... 701(e)(3) of the Act, which requires the Secretary to establish rules designed to prevent an...

  4. 40 CFR 97.213 - Certificate of representation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR Designated Representative for CAIR SO2 Sources § 97.213 Certificate of representation. (a) A complete certificate of... the following elements in a format prescribed by the Administrator: (1) Identification of the CAIR SO2...

  5. 9 CFR 205.101 - Certification-request and processing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... an introductory explanation of how the system will operate; (2) Identify the information which will... the system is created and operated, and the system operator is designated; (ii) All regulations, rules... certification of a system, a written request for certification must be filed together with such documents as...

  6. 9 CFR 205.101 - Certification-request and processing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... an introductory explanation of how the system will operate; (2) Identify the information which will... the system is created and operated, and the system operator is designated; (ii) All regulations, rules... certification of a system, a written request for certification must be filed together with such documents as...

  7. 24 CFR 200.950 - Building product standards and certification program for solar water heating system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... certification program for solar water heating system. 200.950 Section 200.950 Housing and Urban Development... solar water heating system. (a) Applicable standards. (1) All solar water heating systems shall be designed, manufactured, and tested in compliance with Solar Rating and Certification Corporation (SRCC...

  8. 24 CFR 200.950 - Building product standards and certification program for solar water heating system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... certification program for solar water heating system. 200.950 Section 200.950 Housing and Urban Development... solar water heating system. (a) Applicable standards. (1) All solar water heating systems shall be designed, manufactured, and tested in compliance with Solar Rating and Certification Corporation (SRCC...

  9. 24 CFR 200.950 - Building product standards and certification program for solar water heating system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... certification program for solar water heating system. 200.950 Section 200.950 Housing and Urban Development... solar water heating system. (a) Applicable standards. (1) All solar water heating systems shall be designed, manufactured, and tested in compliance with Solar Rating and Certification Corporation (SRCC...

  10. 49 CFR 240.103 - Approval of design of individual railroad programs by FRA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Approval of design of individual railroad programs... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION QUALIFICATION AND CERTIFICATION OF... individual railroad programs by FRA. (a) Each railroad shall submit its written certification program and a...

  11. 40 CFR 98.4 - Authorization and responsibilities of the designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Administrator of a complete certificate of representation under this section for a facility or supplier, the designated representative identified in such certificate of representation shall represent and, by his or her representations, actions, inactions, or submissions, legally bind each owner and operator of such facility or...

  12. 40 CFR 35.2050 - Effect of approval or certification of documents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2050 Effect of approval or certification of documents. Review or approval of facilities plans, design drawings... relieve the grantee of its responsibility to properly plan, design, build and effectively operate and...

  13. 46 CFR 62.20-5 - Self-certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Self-certification. 62.20-5 Section 62.20-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Plan... certify to the Coast Guard, in writing, that the automation is designed to meet the environmental design...

  14. 76 FR 72087 - Special Conditions: Diamond Aircraft Industries, Model DA-40NG; Electronic Engine Control (EEC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... engine design certification, and the certification requirements for engine control systems are driven by... following novel or unusual design features: Electronic engine control system. Discussion As discussed above...; Electronic Engine Control (EEC) System AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final...

  15. Innovative Approaches to Flaw-Tolerant Design and Certification of Airframe Components. Report on NACA Data- Task 6

    DTIC Science & Technology

    2017-10-16

    parameter A3 of the design curve is negative for 24S-T3. The design curve shown in Figure 41 for Model S2 is comparable with the design curve shown...Approaches to Flaw-Tolerant Design and Certification of Airframe Components Report on NACA Data – Task 6 Ricardo Actis and Barna Szabó Engineering...Software Research and Development, Inc. 111 West Port Plaza, Suite 825 St. Louis, MO 63146 September 26, 2017 Revised: October 16, 2017

  16. MULTI-OBJECTIVE ONLINE OPTIMIZATION OF BEAM LIFETIME AT APS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sun, Yipeng

    In this paper, online optimization of beam lifetime at the APS (Advanced Photon Source) storage ring is presented. A general genetic algorithm (GA) is developed and employed for some online optimizations in the APS storage ring. Sextupole magnets in 40 sectors of the APS storage ring are employed as variables for the online nonlinear beam dynamics optimization. The algorithm employs several optimization objectives and is designed to run with topup mode or beam current decay mode. Up to 50\\% improvement of beam lifetime is demonstrated, without affecting the transverse beam sizes and other relevant parameters. In some cases, the top-upmore » injection efficiency is also improved.« less

  17. Baseline water quality of Long Meadow Lake, Ponds AP-9 and AP-10, and Black Dog Creek, Hennepin and Dakota counties, Minnesota

    USGS Publications Warehouse

    Payne, G.A.

    1977-01-01

    Long Meadow Lake, Black Dog Creek, and Ponds AP-9 and AP-10 which lie in an area designated for a trunk highway bridge crossing the Minnesota River, were sampled for baseline water quality prior to construction of the bridge. Data collected show that dissolved solids fluctuate seasonally. Dissolved oxygen:/ranged from less than 1 milligram per liter under an ice cover to 13-9 milligrams per liter in the September sample at site 4 in Long Meadow Lake. The phytoplankton analyses showed pulses in algae populations, blue-green algae being the dominant type in at least one sample from each of the water courses.

  18. Development and operating experience of a 1.1-m-long superconducting undulator at the Advanced Photon Source

    NASA Astrophysics Data System (ADS)

    Ivanyushenkov, Y.; Harkay, K.; Borland, M.; Dejus, R.; Dooling, J.; Doose, C.; Emery, L.; Fuerst, J.; Gagliano, J.; Hasse, Q.; Kasa, M.; Kenesei, P.; Sajaev, V.; Schroeder, K.; Sereno, N.; Shastri, S.; Shiroyanagi, Y.; Skiadopoulos, D.; Smith, M.; Sun, X.; Trakhtenberg, E.; Xiao, A.; Zholents, A.; Gluskin, E.

    2017-10-01

    Development of superconducting undulators continues at the Advanced Photon Source (APS). Two years after successful installation and commissioning of the first relatively short superconducting undulator "SCU0" in Sector 6 of the APS storage ring, the second 1.1-m-long superconducting undulator "SCU1" was installed in Sector 1 of the APS. The device has been in user operation since its commissioning in May 2015. This paper describes the magnetic and cryogenic design of the SCU1 together with the results of stand-alone cold tests. The SCU1's magnetic and cryogenic performance as well as its operating experience in the APS storage ring are also presented.

  19. Integrated imaging sensor systems with CMOS active pixel sensor technology

    NASA Technical Reports Server (NTRS)

    Yang, G.; Cunningham, T.; Ortiz, M.; Heynssens, J.; Sun, C.; Hancock, B.; Seshadri, S.; Wrigley, C.; McCarty, K.; Pain, B.

    2002-01-01

    This paper discusses common approaches to CMOS APS technology, as well as specific results on the five-wire programmable digital camera-on-a-chip developed at JPL. The paper also reports recent research in the design, operation, and performance of APS imagers for several imager applications.

  20. Designing to Promote Access, Quality, and Student Support in an Advanced Certificate Programme for Rural Teachers in South Africa

    ERIC Educational Resources Information Center

    Fresen, Jill W.; Hendrikz, Johan

    2009-01-01

    This paper reports on the re-design of the Advanced Certificate in Education (ACE) programme, which is offered by the University of Pretoria through distance education (DE) to teachers in rural South Africa. In 2007, a team re-designed the programme with the goal of promoting access, quality, and student support. The team included an independent…

  1. Online continuing interprofessional education on hospital-acquired infections for Latin America.

    PubMed

    Medina-Presentado, Julio C; Margolis, Alvaro; Teixeira, Lucia; Lorier, Leticia; Gales, Ana C; Pérez-Sartori, Graciela; Oliveira, Maura S; Seija, Verónica; Paciel, Daniela; Vignoli, Rafael; Guerra, Silvia; Albornoz, Henry; Arteta, Zaida; Lopez-Arredondo, Antonio; García, Sofía

    Latin America is a large and diverse region, comprising more than 600 million inhabitants and one million physicians in over 20 countries. Resistance to antibacterial drugs is particularly important in the region. This paper describes the design, implementation and results of an international bi-lingual (Spanish and Portuguese) online continuing interprofessional interactive educational program on hospital-acquired infections and antimicrobial resistance for Latin America, supported by the American Society for Microbiology. Participation, satisfaction and knowledge gain (through pre and post tests) were used. Moreover, commitment to change statements were requested from participants at the end of the course and three months later. There were 1169 participants from 19 Latin American countries who registered: 57% were physicians and 43% were other health care professionals. Of those, 1126 participated in the course, 46% received a certificate of completion and 54% a certificate of participation. There was a significant increase in knowledge between before and after the course. Of 535 participants who took both tests, the grade increased from 59 to 81%. Commitments to change were aligned with course objectives. Implementation of this educational program showed the feasibility of a continent-wide interprofessional massive course on hospital acquired-infections in Latin America, in the two main languages spoken in the region. Next steps included a new edition of this course and a "New Challenges" course on hospital-acquired infections, which were successfully implemented in the second semester of 2015 by the same institutions. Copyright © 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

  2. A CoAP-Based Network Access Authentication Service for Low-Power Wide Area Networks: LO-CoAP-EAP.

    PubMed

    Garcia-Carrillo, Dan; Marin-Lopez, Rafael; Kandasamy, Arunprabhu; Pelov, Alexander

    2017-11-17

    The Internet-of-Things (IoT) landscape is expanding with new radio technologies. In addition to the Low-Rate Wireless Personal Area Network (LR-WPAN), the recent set of technologies conforming the so-called Low-Power Wide Area Networks (LP-WAN) offers long-range communications, allowing one to send small pieces of information at a reduced energy cost, which promotes the creation of new IoT applications and services. However, LP-WAN technologies pose new challenges since they have strong limitations in the available bandwidth. In general, a first step prior to a smart object being able to gain access to the network is the process of network access authentication. It involves authentication, authorization and key management operations. This process is of vital importance for operators to control network resources. However, proposals for managing network access authentication in LP-WAN are tailored to the specifics of each technology, which could introduce interoperability problems in the future. In this sense, little effort has been put so far into providing a wireless-independent solution for network access authentication in the area of LP-WAN. To fill this gap, we propose a service named Low-Overhead CoAP-EAP (LO-CoAP-EAP), which is based on previous work designed for LR-WPAN. LO-CoAP-EAP integrates the use of Authentication, Authorization and Accounting (AAA) infrastructures and the Extensible Authentication Protocol (EAP) protocol. For this integration, we use the Constrained Application Protocol (CoAP) to design a network authentication service independent of the type of LP-WAN technology. LO-CoAP-EAP represents a trade-off between flexibility, wireless technology independence, scalability and performance in LP-WAN.

  3. A CoAP-Based Network Access Authentication Service for Low-Power Wide Area Networks: LO-CoAP-EAP

    PubMed Central

    Garcia-Carrillo, Dan; Marin-Lopez, Rafael; Kandasamy, Arunprabhu; Pelov, Alexander

    2017-01-01

    The Internet-of-Things (IoT) landscape is expanding with new radio technologies. In addition to the Low-Rate Wireless Personal Area Network (LR-WPAN), the recent set of technologies conforming the so-called Low-Power Wide Area Networks (LP-WAN) offers long-range communications, allowing one to send small pieces of information at a reduced energy cost, which promotes the creation of new IoT applications and services. However, LP-WAN technologies pose new challenges since they have strong limitations in the available bandwidth. In general, a first step prior to a smart object being able to gain access to the network is the process of network access authentication. It involves authentication, authorization and key management operations. This process is of vital importance for operators to control network resources. However, proposals for managing network access authentication in LP-WAN are tailored to the specifics of each technology, which could introduce interoperability problems in the future. In this sense, little effort has been put so far into providing a wireless-independent solution for network access authentication in the area of LP-WAN. To fill this gap, we propose a service named Low-Overhead CoAP-EAP (LO-CoAP-EAP), which is based on previous work designed for LR-WPAN. LO-CoAP-EAP integrates the use of Authentication, Authorization and Accounting (AAA) infrastructures and the Extensible Authentication Protocol (EAP) protocol. For this integration, we use the Constrained Application Protocol (CoAP) to design a network authentication service independent of the type of LP-WAN technology. LO-CoAP-EAP represents a trade-off between flexibility, wireless technology independence, scalability and performance in LP-WAN. PMID:29149040

  4. Tuning of Terahertz Resonances of Pyridyl Benzamide Derivatives by Electronegative Atom Substitution

    NASA Astrophysics Data System (ADS)

    Dash, Jyotirmayee; Ray, Shaumik; Devi, Nirmala; Basutkar, Nitin; Gonnade, Rajesh G.; Ambade, Ashootosh V.; Pesala, Bala

    2018-05-01

    N-(pyridin-2-yl) benzamide (Ph2AP)-based organic molecules with prominent terahertz (THz) signatures (less than 5 THz) have been synthesized. The THz resonances are tuned by substituting the most electronegative atom, fluorine, at ortho (2F-Ph2AP), meta (3F-Ph2AP), and para (4F-Ph2AP) positions in a Ph2AP molecule. Substitution of fluorine helps in varying the charge distribution of the atoms forming hydrogen bond and hence strength of the hydrogen bond is varied which helps in tuning the THz resonances. The tuning of lower THz resonances of 2F-Ph2AP, 3F-Ph2AP, and 4F-Ph2AP has been explained in terms of compliance constant (relaxed force constant). Four-molecule cluster simulations have been carried out using Gaussian09 software to calculate the compliance constant of the hydrogen bonds. Crystal structure simulations of the above molecules using CRYSTAL14 software have been carried out to understand the origin of THz resonances. It has been observed that THz resonances are shifted to higher frequencies with stronger hydrogen bonds. The study shows that 3F-Ph2AP and 4F-Ph2AP have higher hydrogen bond strength and hence the THz resonances originating due to stretching of intermolecular hydrogen bonds have been shifted to higher frequencies compared to 2F-Ph2AP. The methodology presented here will help in designing novel organic molecules by substituting various electronegative atoms in order to achieve prominent THz resonances.

  5. The soil sulphate effect and maize plant (Zea mays L.) growth of sulphate reducing bacteria (SRB) inoculation in acid sulfate soils with the different soil water condition

    NASA Astrophysics Data System (ADS)

    Asmarlaili, S.; Rauf, A.; Hanafiah, D. S.; Sudarno, Y.; Abdi, P.

    2018-02-01

    The objective of the study was to determine the potential application of sulphate reducing bacteria on acid sulfate soil with different water content in the green house. The research was carried out in the Laboratory and Green House, Faculty of Agriculture, Universitas Sumatera Utara. This research used Randomized Block Design with two treatments factors, ie sulphate reducing bacteria (SRB) isolate (control, LK4, LK6, TSM4, TSM3, AP4, AP3, LK4 + TSM3, LK4 + AP4, LK4 + AP3, LK6 + TSM3, LK6 + AP4, LK6 + AP3, TSM4 + TSM3, TSM4 + AP4, TSM4 + AP3) and water condition (100% field capacity and 110% field capacity). The results showed that application of isolate LK4 + AP4 with water condition 110% field capacity decreased the soil sulphate content (27.38 ppm) significantly after 6 weeks. Application of isolate LK4 + AP3 with water condition 110% field capacity increased soil pH (5.58) after-week efficacy 6. Application of isolate LK4 with water condition 110% field capacity increased plant growth (140 cm; 25.74 g) significantly after week 6. The best treatment was application isolate LK4 with water condition 110% field Capacity (SRB population 2.5x108; soil sulphate content 29.10ppm; soil acidity 4.78; plant height 140cm; plant weight 25.74g).

  6. Effect of voluntary soft tissue tension and articular conformity after total knee arthroplasty on in vivo anteroposterior displacement.

    PubMed

    Ishii, Y; Noguchi, H; Takeda, M; Kiga, H; Toyabe, S I

    2011-01-01

    The in vivo relationship between the degree of voluntary soft tissue tension and articular conformity after total knee arthroplasty (TKA) and anteroposterior (AP) displacement was simultaneously investigated by analyzing LCS prostheses (posterior cruciate ligament-sacrificing rotating platform design) in 20 knees from 20 patients. AP displacement was measured using the KT-2000 arthrometer, at 30° and 75° flexion, while patients were conscious and under anesthesia; 30° flexion was regarded as high conformity and 75° as low conformity. Mean displacements at 30° and 75° were 5.1mm and 7.0mm, respectively, in conscious patients, and 6.7 mm and 7.7 mm, respectively, in patients under anesthesia. AP displacement was significantly associated with soft tissue tension (p=0.026) and conformity (p=0.001). No interaction was observed between the two variables (p=0.193). Surgeons should recognize that AP displacement is greater in anesthetized patients than in conscious patients, regardless of the degree of conformity, and that higher conformity shows less displacement, regardless of the degree of soft tissue tension. These results may help surgeons to determine the intra-operative AP displacement required for proper postoperative displacement in the current prosthetic design. Copyright © 2009 Elsevier B.V. All rights reserved.

  7. Optical stimulation of the facial nerve: a surgical tool?

    NASA Astrophysics Data System (ADS)

    Richter, Claus-Peter; Teudt, Ingo Ulrik; Nevel, Adam E.; Izzo, Agnella D.; Walsh, Joseph T., Jr.

    2008-02-01

    One sequela of skull base surgery is the iatrogenic damage to cranial nerves. Devices that stimulate nerves with electric current can assist in the nerve identification. Contemporary devices have two main limitations: (1) the physical contact of the stimulating electrode and (2) the spread of the current through the tissue. In contrast to electrical stimulation, pulsed infrared optical radiation can be used to safely and selectively stimulate neural tissue. Stimulation and screening of the nerve is possible without making physical contact. The gerbil facial nerve was irradiated with 250-μs-long pulses of 2.12 μm radiation delivered via a 600-μm-diameter optical fiber at a repetition rate of 2 Hz. Muscle action potentials were recorded with intradermal electrodes. Nerve samples were examined for possible tissue damage. Eight facial nerves were stimulated with radiant exposures between 0.71-1.77 J/cm2, resulting in compound muscle action potentials (CmAPs) that were simultaneously measured at the m. orbicularis oculi, m. levator nasolabialis, and m. orbicularis oris. Resulting CmAP amplitudes were 0.3-0.4 mV, 0.15-1.4 mV and 0.3-2.3 mV, respectively, depending on the radial location of the optical fiber and the radiant exposure. Individual nerve branches were also stimulated, resulting in CmAP amplitudes between 0.2 and 1.6 mV. Histology revealed tissue damage at radiant exposures of 2.2 J/cm2, but no apparent damage at radiant exposures of 2.0 J/cm2.

  8. Industry Supplied CAD Curriculum: Case Study on Passing Certification Exams

    ERIC Educational Resources Information Center

    Webster, Rustin; Dues, Joseph; Ottway, Rudy

    2017-01-01

    Students who successfully pass professional certification exams while in school are often targeted first by industry for internships and entry level positions. Over the last decade, leading industry suppliers of computer-aided design (CAD) software have developed and launched certification exams for many of their product offerings. Some have also…

  9. 24 CFR 200.936 - Supplementary specific procedural requirements under HUD building products certification program...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... fireplace stoves certified under the HUD Building Products Certification Program shall be designed... and manufacturer series or model number; and (iv) The type of fuel to be used. (2) The certification... Accreditation Program. (2) The administrator shall visit the manufacturer's facility two times a year to assure...

  10. 24 CFR 200.936 - Supplementary specific procedural requirements under HUD building products certification program...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... fireplace stoves certified under the HUD Building Products Certification Program shall be designed... and manufacturer series or model number; and (iv) The type of fuel to be used. (2) The certification... Accreditation Program. (2) The administrator shall visit the manufacturer's facility two times a year to assure...

  11. 24 CFR 200.936 - Supplementary specific procedural requirements under HUD building products certification program...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... fireplace stoves certified under the HUD Building Products Certification Program shall be designed... and manufacturer series or model number; and (iv) The type of fuel to be used. (2) The certification... Accreditation Program. (2) The administrator shall visit the manufacturer's facility two times a year to assure...

  12. 24 CFR 200.936 - Supplementary specific procedural requirements under HUD building products certification program...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... fireplace stoves certified under the HUD Building Products Certification Program shall be designed... and manufacturer series or model number; and (iv) The type of fuel to be used. (2) The certification... Accreditation Program. (2) The administrator shall visit the manufacturer's facility two times a year to assure...

  13. Validation of Rehabilitation Counseling Accreditation and Certification Knowledge Areas: Methodology and Initial Results.

    ERIC Educational Resources Information Center

    Szymanski, Edna Mora; And Others

    1993-01-01

    Conducted ongoing study to validate and update knowledge standards for rehabilitation counseling accreditation and certification, using descriptive, ex post facto, and time-series designs and three sampling frames. Findings from 1,025 counselors who renewed their certification in 1991 revealed that 52 of 55 knowledge standards were rated as at…

  14. The Psychometric Properties of the Agricultural Hazardous Occupations Order Certification Training Program Written Examinations

    ERIC Educational Resources Information Center

    French, Brian F.; Breidenbach, Daniel H.; Field, William E.; Tormoehlen, Roger

    2007-01-01

    The written certification exam that accompanies the Gearing Up for Safety-Agricultural Production Safety Training for Youth curriculum was designed to partially meet the testing requirements of the Agricultural Hazardous Occupations Order (AgHOs) Certification Training Program. This curriculum and accompanying assessment tools are available for…

  15. 40 CFR 96.213 - Certificate of representation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS CAIR Designated Representative for CAIR SO2 Sources § 96.213 Certificate of representation. (a) A...) Identification of the CAIR SO2 source, and each CAIR SO2 unit at the source, for which the certificate of...

  16. 46 CFR 91.25-38 - Pollution prevention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Pollution prevention. 91.25-38 Section 91.25-38 Shipping... CERTIFICATION Inspection for Certification § 91.25-38 Pollution prevention. At each inspection for certification... design and equipment requirements for pollution prevention in 33 CFR part 155, subpart B. [CGD 71-161R...

  17. 46 CFR 91.25-38 - Pollution prevention.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Pollution prevention. 91.25-38 Section 91.25-38 Shipping... CERTIFICATION Inspection for Certification § 91.25-38 Pollution prevention. At each inspection for certification... design and equipment requirements for pollution prevention in 33 CFR part 155, subpart B. [CGD 71-161R...

  18. 46 CFR 91.25-38 - Pollution prevention.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Pollution prevention. 91.25-38 Section 91.25-38 Shipping... CERTIFICATION Inspection for Certification § 91.25-38 Pollution prevention. At each inspection for certification... design and equipment requirements for pollution prevention in 33 CFR part 155, subpart B. [CGD 71-161R...

  19. 46 CFR 91.25-38 - Pollution prevention.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Pollution prevention. 91.25-38 Section 91.25-38 Shipping... CERTIFICATION Inspection for Certification § 91.25-38 Pollution prevention. At each inspection for certification... design and equipment requirements for pollution prevention in 33 CFR part 155, subpart B. [CGD 71-161R...

  20. 46 CFR 91.25-38 - Pollution prevention.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Pollution prevention. 91.25-38 Section 91.25-38 Shipping... CERTIFICATION Inspection for Certification § 91.25-38 Pollution prevention. At each inspection for certification... design and equipment requirements for pollution prevention in 33 CFR part 155, subpart B. [CGD 71-161R...

  1. Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release

    PubMed Central

    Huang, Wei; Cane, Matthew C; Mukherjee, Rajarshi; Szatmary, Peter; Zhang, Xiaoying; Elliott, Victoria; Ouyang, Yulin; Chvanov, Michael; Latawiec, Diane; Wen, Li; Booth, David M; Haynes, Andrea C; Petersen, Ole H; Tepikin, Alexei V; Criddle, David N

    2017-01-01

    Objective Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determined effects of caffeine and its xanthine metabolites on pancreatic acinar IP3R-mediated Ca2+ signalling and experimental AP. Design Isolated pancreatic acinar cells were exposed to secretagogues, uncaged IP3 or toxins that induce AP and effects of xanthines, non-xanthine phosphodiesterase (PDE) inhibitors and cyclic adenosine monophosphate and cyclic guanosine monophosphate (cAMP/cGMP) determined. The intracellular cytosolic calcium concentration ([Ca2+]C), mitochondrial depolarisation and necrosis were assessed by confocal microscopy. Effects of xanthines were evaluated in caerulein-induced AP (CER-AP), taurolithocholic acid 3-sulfate-induced AP (TLCS-AP) or palmitoleic acid plus ethanol-induced AP (fatty acid ethyl ester AP (FAEE-AP)). Serum xanthines were measured by liquid chromatography-mass spectrometry. Results Caffeine, dimethylxanthines and non-xanthine PDE inhibitors blocked IP3-mediated Ca2+ oscillations, while monomethylxanthines had little effect. Caffeine and dimethylxanthines inhibited uncaged IP3-induced Ca2+ rises, toxin-induced Ca2+ release, mitochondrial depolarisation and necrotic cell death pathway activation; cAMP/cGMP did not inhibit toxin-induced Ca2+ rises. Caffeine significantly ameliorated CER-AP with most effect at 25 mg/kg (seven injections hourly); paraxanthine or theophylline did not. Caffeine at 25 mg/kg significantly ameliorated TLCS-AP and FAEE-AP. Mean total serum levels of dimethylxanthines and trimethylxanthines peaked at >2 mM with 25 mg/kg caffeine but at <100 µM with 25 mg/kg paraxanthine or theophylline. Conclusions Caffeine and its dimethylxanthine metabolites reduced pathological IP3R-mediated pancreatic acinar Ca2+ signals but only caffeine ameliorated experimental AP. Caffeine is a suitable starting point for medicinal chemistry. PMID:26642860

  2. 40 CFR 96.210 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR SO2 source... a complete certificate of representation under § 96.213 for a CAIR designated representative of the...

  3. 40 CFR 96.210 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR SO2 source... a complete certificate of representation under § 96.213 for a CAIR designated representative of the...

  4. 40 CFR 96.110 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR NOX source... received a complete certificate of representation under § 96.113 for a CAIR designated representative of...

  5. 40 CFR 96.110 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR NOX source... received a complete certificate of representation under § 96.113 for a CAIR designated representative of...

  6. 40 CFR 96.110 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR NOX source... received a complete certificate of representation under § 96.113 for a CAIR designated representative of...

  7. 40 CFR 96.210 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR SO2 source... a complete certificate of representation under § 96.213 for a CAIR designated representative of the...

  8. 40 CFR 96.110 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR NOX source... received a complete certificate of representation under § 96.113 for a CAIR designated representative of...

  9. 40 CFR 96.210 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR SO2 source... a complete certificate of representation under § 96.213 for a CAIR designated representative of the...

  10. 40 CFR 96.110 - Authorization and responsibilities of CAIR designated representative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...)(4)(iv). (c) Upon receipt by the Administrator of a complete certificate of representation under § 96... representations, actions, inactions, or submissions, legally bind each owner and operator of the CAIR NOX source... received a complete certificate of representation under § 96.113 for a CAIR designated representative of...

  11. 9 CFR 592.5 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Designation of official certificates... Section 592.5 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... class, quality, quantity, or condition specified in this part or any symbol, stamp, label, or seal...

  12. 9 CFR 592.5 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Designation of official certificates... Section 592.5 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... class, quality, quantity, or condition specified in this part or any symbol, stamp, label, or seal...

  13. 14 CFR 1204.505 - Delegation of authority to execute certificates of full faith and credit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Delegation of authority to execute... SPACE ADMINISTRATION ADMINISTRATIVE AUTHORITY AND POLICY Delegations and Designations § 1204.505 Delegation of authority to execute certificates of full faith and credit. (a) Scope. This section designates...

  14. 10 CFR 2.819 - Denial of application for failure to supply information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... (a) The Commission may deny an application for a standard design certification if an applicant fails... applicant has failed to respond in a timely fashion to a request for additional information, the NRC will... rulemaking, or notice of proposed rulemaking for a standard design certification was published on the NRC Web...

  15. 10 CFR 2.819 - Denial of application for failure to supply information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... (a) The Commission may deny an application for a standard design certification if an applicant fails... applicant has failed to respond in a timely fashion to a request for additional information, the NRC will... rulemaking, or notice of proposed rulemaking for a standard design certification was published on the NRC Web...

  16. 29 CFR 1919.32 - Specially designed blocks and components.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Specially designed blocks and components. 1919.32 Section 1919.32 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) GEAR CERTIFICATION Certification of Vessels: Tests and Proof Loads; Heat Treatment; Competent Persons § 1919.32...

  17. 7 CFR 58.2 - Designation of official certificates, memoranda, marks, identifications, and devices for purpose...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Designation of official certificates, memoranda, marks, identifications, and devices for purpose of the Agricultural Marketing Act. 58.2 Section 58.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices),...

  18. 7 CFR 56.2 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Designation of official certificates, memoranda, marks, other identifications, and devices for purposes of the Agricultural Marketing Act. 56.2 Section 56.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices),...

  19. 7 CFR 53.2 - Designation of official certificates, memoranda, marks, other identifications, for purposes of...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Designation of official certificates, memoranda, marks, other identifications, for purposes of the Agricultural Marketing Act. 53.2 Section 53.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT...

  20. 7 CFR 54.1003 - Designation of official certificates, memoranda, marks, and other identifications, for purposes...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Designation of official certificates, memoranda, marks, and other identifications, for purposes of the Agricultural Marketing Act. 54.1003 Section 54.1003 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices),...

  1. 14 CFR 121.153 - Aircraft requirements: General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... identification requirements of that country; (2) The aircraft is of a type design which is approved under a U.S. type certificate and complies with all of the requirements of this chapter (14 CFR Chapter 1) that... which must be met for issuance of a U.S. standard airworthiness certificate (including type design...

  2. Evidence for effective structure-based neuromodulatory effects of new analogues of neurosteroid allopregnanolone.

    PubMed

    Taleb, O; Patte-Mensah, C; Meyer, L; Kemmel, V; Geoffroy, P; Miesch, M; Mensah-Nyagan, A-G

    2018-02-01

    The neurosteroid allopregnanolone (AP) modulates neuroendocrine/neurobiological processes, including hypothalamic-pituitary-adrenocortical activities, pain, anxiety, neurogenesis and neuroprotection. These observations raised the hope of developing AP-based therapies against neuroendocrine and/or neurodegenerative disorders. However, the pleiotropic actions of AP, particularly its cell-proliferation-promoting effects, hamper the development of selective/targeted therapies. For example, although AP-induced neurogenesis may serve to compensate neuronal loss in degenerative brains, AP-evoked cell-proliferation is contraindicated for steroid-sensitive cancer patients. To foster progress, we synthesised 4 novel AP analogues of neurosteroids (ANS) designated BR053 (12-oxo-epi-AP), BR297 (O-allyl-epi-AP), BR351 (O-allyl-AP) and BR338 (12-oxo-AP). First, because AP is well-known as allosteric modulator of GABAA receptors (GABAA-R), we used the electrophysiological patch-clamp technique to determine the structure-activity relationship of our ANS on GABAA-activated current in NCB20 cells expressing functional GABAA-R. We found that the addition of 12-oxo-group did not significantly change the respective positive or negative allosteric effects of 3α-AP or 3β-(epi)-AP analogues. Importantly, substitution of the 3α-hydroxyl-group by 3α-O-allyl highly modified the ANS activities. Unlike AP, BR351 induced a long-lasting desensitisation/inhibition of GABAA-R. Interestingly, replacement of the 3β-hydroxyl by 3β-O-allyl (BR297) completely reversed the activity from negative to positive allosteric action. In a second step, we compared the actions of AP and ANS on SH-SY5Y neuronal cell viability/proliferation using MTT-reduction assays. Different dose-response curves were demonstrated for AP and the ANS. By contrast to AP, BR297 was totally devoid of cell-proliferative effect. Finally, we compared AP and ANS abilities to protect against oxidative stress-induced neuronal death pivotally involved in neurodegenerative diseases. Both BR351 and BR297 had notable advantages over AP in protecting SH-SY5Y cells against oxidative stress-induced death. Thus, BR297 appears to be a potent neuroprotective compound devoid of cell-proliferative activity. Altogether, our results suggest promising perspectives for the development of neurosteroid-based selective and effective strategies against neuroendocrine and/or neurodegenerative disorders. © 2017 British Society for Neuroendocrinology.

  3. A Novel User Classification Method for Femtocell Network by Using Affinity Propagation Algorithm and Artificial Neural Network

    PubMed Central

    Ahmed, Afaz Uddin; Tariqul Islam, Mohammad; Ismail, Mahamod; Kibria, Salehin; Arshad, Haslina

    2014-01-01

    An artificial neural network (ANN) and affinity propagation (AP) algorithm based user categorization technique is presented. The proposed algorithm is designed for closed access femtocell network. ANN is used for user classification process and AP algorithm is used to optimize the ANN training process. AP selects the best possible training samples for faster ANN training cycle. The users are distinguished by using the difference of received signal strength in a multielement femtocell device. A previously developed directive microstrip antenna is used to configure the femtocell device. Simulation results show that, for a particular house pattern, the categorization technique without AP algorithm takes 5 indoor users and 10 outdoor users to attain an error-free operation. While integrating AP algorithm with ANN, the system takes 60% less training samples reducing the training time up to 50%. This procedure makes the femtocell more effective for closed access operation. PMID:25133214

  4. A novel user classification method for femtocell network by using affinity propagation algorithm and artificial neural network.

    PubMed

    Ahmed, Afaz Uddin; Islam, Mohammad Tariqul; Ismail, Mahamod; Kibria, Salehin; Arshad, Haslina

    2014-01-01

    An artificial neural network (ANN) and affinity propagation (AP) algorithm based user categorization technique is presented. The proposed algorithm is designed for closed access femtocell network. ANN is used for user classification process and AP algorithm is used to optimize the ANN training process. AP selects the best possible training samples for faster ANN training cycle. The users are distinguished by using the difference of received signal strength in a multielement femtocell device. A previously developed directive microstrip antenna is used to configure the femtocell device. Simulation results show that, for a particular house pattern, the categorization technique without AP algorithm takes 5 indoor users and 10 outdoor users to attain an error-free operation. While integrating AP algorithm with ANN, the system takes 60% less training samples reducing the training time up to 50%. This procedure makes the femtocell more effective for closed access operation.

  5. Gapminder: An AP Human Geography Lab Assignment

    ERIC Educational Resources Information Center

    Keller, Kenneth H.

    2012-01-01

    This lesson is designed as a lab assignment for Advanced Placement (AP) Human Geography students wherein they use the popular Gapminder web site to compare levels of development in countries from different world regions. For this lesson, it is important for the teacher to practice with Gapminder before giving the assignment to students. (Contains…

  6. The AP Descriptive Chemistry Question: Student Errors

    ERIC Educational Resources Information Center

    Crippen, Kent; Brooks, David W.

    2005-01-01

    For over a decade, the authors have been involved in a design theory experiment providing software for high school students preparing for the descriptive question on the Advanced Placement (AP) chemistry examination. Since 1997, the software has been available as a Web site offering repeatable practice. This study describes a 4-year project during…

  7. Surviving a Midlife Crisis: Advanced Placement Turns Fifty

    ERIC Educational Resources Information Center

    Mollison, Andrew

    2006-01-01

    In 1956, 1,220 college-bound juniors and seniors in 104 American high schools took the first Advanced Placement (AP) exams conducted by the Educational Testing Service for the College Board. The AP program was unabashedly elitist and designed to fortify the education of the nation's future leaders in anticipation of Cold War national security…

  8. Particle Sizer

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Microspheres are tiny plastic beads that represent the first commercial products manufactured in orbit. An example of how they are used is a new aerodynamic particle sizer designated APS 33B produced by TSI Incorporated. TSI purchased the microspheres from the National Bureau of Standards which certified their exact size and the company uses them in calibration of the APS 33B* instrument, latest in a line of TSI systems for generating counting and weighing minute particles of submicron size. Instruments are used for evaluating air pollution control devices, quantifying environments, meteorological research, testing filters, inhalation, toxicology and other areas where generation or analysis of small airborne particles is required. * The APS 33B is no longer being manufactured. An improved version, APS 3320, is now being manufactured. 2/28/97

  9. Large-scale boiling experiments of the flooded cavity concept for in-vessel core retention

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chu, T.Y.; Slezak, S.E.; Bentz, J.H.

    1994-03-01

    This paper presents results of ex-vessel boiling experiments performed in the CYBL (CYlindrical BoiLing) facility. CYBL is a reactor-scale facility for confirmatory research of the flooded cavity concept for accident management. CYBL has a tank-within-a-tank design; the inner tank simulates the reactor vessel and the outer tank simulates the reactor cavity. Experiments with uniform and edge-peaked heat flux distributions up to 20 W/cm{sup 2} across the vessel bottom were performed. Boiling outside the reactor vessel was found to be subcooled nucleate boiling. The subcooling is mainly due to the gravity head which results from flooding the sides of the reactormore » vessel. The boiling process exhibits a cyclic pattern with four distinct phases: direct liquid/solid contact, bubble nucleation and growth, coalescence, and vapor mass dispersion (ejection). The results suggest that under prototypic heat load and heat flux distributions, the flooded cavity in a passive pressurized water reactor like the AP-600 should be capable of cooling the reactor pressure vessel in the central region of the lower head that is addressed by these tests.« less

  10. Conceptual studies on the integration of a nuclear reactor system to a manned rover for Mars missions

    NASA Technical Reports Server (NTRS)

    El-Genk, Mohamed S.; Morley, Nicholas J.

    1991-01-01

    Multiyear civilian manned missions to explore the surface of Mars are thought by NASA to be possible early in the next century. Expeditions to Mars, as well as permanent bases, are envisioned to require enhanced piloted vehicles to conduct science and exploration activities. Piloted rovers, with 30 kWe user net power (for drilling, sampling and sample analysis, onboard computer and computer instrumentation, vehicle thermal management, and astronaut life support systems) in addition to mobility are being considered. The rover design, for this study, included a four car train type vehicle complete with a hybrid solar photovoltaic/regenerative fuel cell auxiliary power system (APS). This system was designed to power the primary control vehicle. The APS supplies life support power for four astronauts and a limited degree of mobility allowing the primary control vehicle to limp back to either a permanent base or an accent vehicle. The results showed that the APS described above, with a mass of 667 kg, was sufficient to provide live support power and a top speed of five km/h for 6 hours per day. It was also seen that the factors that had the largest effect on the APS mass were the life support power, the number of astronauts, and the PV cell efficiency. The topics covered include: (1) power system options; (2) rover layout and design; (3) parametric analysis of total mass and power requirements for a manned Mars rover; (4) radiation shield design; and (5) energy conversion systems.

  11. 76 FR 67534 - Federal Fiscal Year 2012 Annual List of Certifications and Assurances for Federal Transit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    .... c. Submit Your Applicant's Certifications and Assurances. You must submit all groups of the FY 2012... groups. Those that do not apply to your Applicant or its project will not be enforced. d. Obtain the... contains fields for selecting among the 24 groups of certifications and assurances and a designated field...

  12. Performance Funding Policy Effects on Community College Outcomes: Are Short-Term Certificates on the Rise?

    ERIC Educational Resources Information Center

    Li, Amy Y.; Kennedy, Alec I.

    2018-01-01

    Objective: Performance funding (PF) policies allocate a portion of state funding to colleges based on student outcomes. This study is the first to account for policy type and design differences, and explores the impact of performance funding on three levels of credential completions: short-term certificates, medium-term certificates, and…

  13. Perspectives on Teaching from Alternative Certification Teachers from Diverse Backgrounds

    ERIC Educational Resources Information Center

    Evans, Brian R.

    2014-01-01

    This article presents an interview with five teachers in an alternative certification program at a university in New York. All of the teachers were from the New York City Teaching Fellows (NYCTF) program, which is an alternative certification program in New York designed to quickly place teachers in high need schools throughout the city. The…

  14. State of the Nation: A Coast-to-Coast Survey of the Latest Certification Standards

    ERIC Educational Resources Information Center

    Thomas, Margie

    2006-01-01

    This article presents the results from a survey that investigated the latest requirements and certification standards for school librarians in each state. In the survey, 42 report they require certification for K-12 library media specialists, meaning that school library candidates must have a bachelor's degree including coursework designed to…

  15. 17 CFR 40.2 - Listing and accepting products for trading or clearing by certification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... products for trading or clearing by certification. (a) Unless permitted otherwise by § 37.7 of this chapter... submission at its headquarters by the open of business on the business day preceding the product's listing or... certification by the designated contract market or derivatives transaction execution facility that the product...

  16. Producer-level benefits of sustainability certification.

    PubMed

    Blackman, Allen; Rivera, Jorge

    2011-12-01

    Initiatives certifying that producers of goods and services adhere to defined environmental and social-welfare production standards are increasingly popular. According to proponents, these initiatives create financial incentives for producers to improve their environmental, social, and economic performance. We reviewed the evidence on whether these initiatives have such benefits. We identified peer-reviewed, ex post, producer-level studies in economic sectors in which certification is particularly prevalent (bananas, coffee, fish products, forest products, and tourism operations), classified these studies on the basis of whether their design and methods likely generated credible results, summarized findings from the studies with credible results, and considered how these findings might guide future research. We found 46 relevant studies, most of which focused on coffee and forest products and examined fair-trade and Forest Stewardship Council certification. The methods used in 11 studies likely generated credible results. Of these 11 studies, nine examined the economic effects and two the environmental effects of certification. The results of four of the 11 studies, all of which examined economic effects, showed that certification has producer-level benefits. Hence, the evidence to support the hypothesis that certification benefits the environment or producers is limited. More evidence could be generated by incorporating rigorous, independent evaluation into the design and implementation of projects promoting certification. ©2011 Society for Conservation Biology.

  17. CLEARING MAGNET DESIGN FOR APS-U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abliz, M.; Grimmer, J.; Jaski, Y.

    2017-06-25

    The Advanced Photon Source is in the process of developing an upgrade (APS-U) of the storage ring. The upgrade will be converting the current double bend achromat (DBA) lattice to a multi-bend achromat (MBA) lattice. In addition, the storage ring will be operated at 6 GeV and 200 mA with regular swap-out injection to keep the stored beam current constant [1]. The swap-out injection will take place with beamline shutters open. For radiation safety to ensure that no electrons can exit the storage ring, a passive method of protecting the beamline and containing the electrons inside the storage ring ismore » proposed. A clearing magnet will be located in all beamline front ends inside the storage ring tunnel. This article will discuss the features and design of the clearing magnet scheme for APS-U.« less

  18. Isolation and characterization of the Jatropha curcas APETALA1 (JcAP1) promoter conferring preferential expression in inflorescence buds.

    PubMed

    Tao, Yan-Bin; He, Liang-Liang; Niu, Longjian; Xu, Zeng-Fu

    2016-08-01

    The 1.5 kb JcAP1 promoter from the biofuel plant Jatropha curcas is predominantly active in the inflorescence buds of transgenic plants, in which the -1313/-1057 region is essential for maintaining the activity. Arabidopsis thaliana APETALA1 (AP1) is a MADS-domain transcription factor gene that functions primarily in flower development. We isolated a homolog of AP1 from Jatropha curcas (designated JcAP1), which was shown to exhibit flower-specific expression in Jatropha. JcAP1 is first expressed in inflorescence buds and continues to be primarily expressed in the sepals. We isolated a 1.5 kb JcAP1 promoter and evaluated its activity in transgenic Arabidopsis and Jatropha using the β-glucuronidase (GUS) reporter gene. In transgenic Arabidopsis and Jatropha, the inflorescence buds exhibited notable GUS activity, whereas the sepals did not. Against expectations, the JcAP1 promoter was active in the anthers of Arabidopsis and Jatropha and was highly expressed in Jatropha seeds. An analysis of promoter deletions in transgenic Arabidopsis revealed that deletion of the -1313/-1057 region resulted in loss of JcAP1 promoter activity in the inflorescence buds and increased activity in the anthers. These results suggested that some regulatory sequences in the -1313/-1057 region are essential for maintaining promoter activity in inflorescence buds and can partly suppress activity in the anthers. Based on these findings, we hypothesized that other elements located upstream of the 1.5 kb JcAP1 promoter may be required for flower-specific activation. The JcAP1 promoter characterized in this study can be used to drive transgene expression in both the inflorescence buds and seeds of Jatropha.

  19. 9 CFR 11.7 - Certification and licensing of designated qualified persons (DQP's).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... instruction on the anatomy and physiology of the limbs of a horse. The instructor teaching the course must be... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Certification and licensing of designated qualified persons (DQP's). 11.7 Section 11.7 Animals and Animal Products ANIMAL AND PLANT HEALTH...

  20. 9 CFR 11.7 - Certification and licensing of designated qualified persons (DQP's).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... instruction on the anatomy and physiology of the limbs of a horse. The instructor teaching the course must be... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Certification and licensing of designated qualified persons (DQP's). 11.7 Section 11.7 Animals and Animal Products ANIMAL AND PLANT HEALTH...

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