A majority of parents of children with peanut allergy fear using the epinephrine auto-injector.

PubMed

Chad, L; Ben-Shoshan, M; Asai, Y; Cherkaoui, S; Alizadehfar, R; St-Pierre, Y; Harada, L; Allen, M; Clarke, A

2013-12-01

Prompt epinephrine administration is crucial in managing anaphylaxis, but epinephrine auto-injectors (EAIs) are underutilized by patients and their families. Children with peanut allergy were recruited from the Allergy Clinics at the Montreal Children's Hospital, food allergy advocacy organizations and organizations providing products to allergic individuals. Parents of children who had been prescribed an EAI were queried on whether they were fearful of using it and on factors that may contribute to fear. A majority of parents (672/1209 = 56%) expressed fear regarding the use of the EAI. Parents attributed the fear to hurting the child, using the EAI incorrectly or a bad outcome. Parents whose child had longer disease duration or a severe reaction and parents who were satisfied with the EAI training or found it easy to use were less likely to be afraid. Families may benefit from simulation training and more education on the recognition and management of anaphylaxis. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The prevalence of diabetes, hypertension and obesity among immigrants from East Africa and the former Soviet Union: a retrospective comparative 30-year cohort study.

PubMed

Reuven, Yonatan; Dreiher, Jacob; Shvartzman, Pesach

2016-05-05

Previous studies have reported an increasing prevalence of metabolic abnormalities in immigrants who moved from low-cardiovascular-risk regions to Western countries, but little is known about time trends following immigration. A retrospective cohort study of immigrants from Ethiopia in east Africa (EAI), the former Soviet Union (FSUI) and native-born Israelis (NBI) over a 35-year period. EAI were divided into three groups by date of immigration. Associations between ethnicity, age, sex and metabolic risk factors were assessed using logistic regression models. The study included 58,901 individuals (20,768 EAI, 20,507 FSUI, and 17,626 NBI). The multivariate odds ratios (OR) for diabetes were 2.4 (95 % CI 2.1-2.6), 2.1 (95 % CI 1.9-2.2) and 1.5 (95 % CI 1.3-1.7), respectively, for the three waves of EAI immigrations (P < 0.001 for trend) and 1.1 (95 % CI 0.9-1.2) for FSUI. For hypertension, the corresponding ORs were 1.8 (95 % CI 1.6-1.9), 1.4 (95 % CI 1.3-1.5), and 1.1 (95 % CI 0.9-1.2), respectively (P < 0.001) for EAI, and 2.1 (95 % CI 1.9-2.2) for FSUI. For obesity the ORs were -0.5 (95 % CI 0.4-0.6), 0.5 (95 % CI 0.4-0.6), and 0.3 (95 % CI 0.2-0.3), respectively (P < 0.001) for EAI, and 1.2 (95 % CI 1.1-1.3) for FSUI. The prevalence of diabetes in NBI with a BMI of 30 was identical to a BMI of 23.4 for EAI and 28.9 for FSUI. The prevalence of diabetes and hypertension was higher in EAI and increased over the years, despite a lower prevalence of obesity. It exceeded the prevalence rates in NBI.

Study of Mycobacterium tuberculosis Complex Genotypic Diversity in Malaysia Reveals a Predominance of Ancestral East-African-Indian Lineage with a Malaysia-Specific Signature

PubMed Central

Ismail, Fazli; Couvin, David; Farakhin, Izzah; Abdul Rahman, Zaidah; Rastogi, Nalin; Suraiya, Siti

2014-01-01

Background Tuberculosis (TB) still constitutes a major public health problem in Malaysia. The identification and genotyping based characterization of Mycobacterium tuberculosis complex (MTBC) isolates causing the disease is important to determine the effectiveness of the control and surveillance programs. Objectives This study intended a first assessment of spoligotyping-based MTBC genotypic diversity in Malaysia followed by a comparison of strains with those prevailing in neighboring countries by comparison with an international MTBC genotyping database. Methods Spoligotyping was performed on a total of 220 M. tuberculosis clinical isolates collected in Kelantan and Kuala Lumpur. The results were compared with the SITVIT2 international database of the Pasteur Institute of Guadeloupe. Results Spoligotyping revealed 77 different patterns: 22 corresponded to orphan patterns while 55 patterns containing 198 isolates were assigned a Spoligo International Type (SIT) designation in the database (the latter included 6 newly created SITs). The eight most common SITs grouped 141 isolates (5 to 56 strains per cluster) as follows: SIT1/Beijing, n = 56, 25.5%; SIT745/EAI1-SOM, n = 33, 15.0%; SIT591/EAI6-BGD1, n = 13, 5.9%; SIT256/EAI5, n = 12, 5.5%; SIT236/EAI5, n = 10, 4.6%; SIT19/EAI2-Manila, n = 9, 4.1%; SIT89/EAI2-Nonthaburi, n = 5, 2.3%; and SIT50/H3, n = 3, 1.4%. The association between city of isolation and lineages was statistically significant; Haarlem and T lineages being higher in Kuala Lumpur (p<0.01). However, no statistically significant differences were noted when comparing drug resistance vs. major lineages, nor between gender and clades. Conclusions The ancestral East-African-Indian (EAI) lineage was most predominant followed by the Beijing lineage. A comparison of strains with those prevailing in neighboring countries in South Asia, East Asia and South East Asia underlined the phylogeographical specificity of SIT745 for Malaysia, and its probable ongoing evolution with locally evolved strains sharing a specific signature characterized by absence of spacers 37, 38, and 40. Pending complementary genotyping confirmation, we propose that SIT745/EAI-SOM is tentatively reclassified as SIT745/EAI-MYS. PMID:25502956

Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries

PubMed Central

Mbugi, Erasto V.; Katale, Bugwesa Z.; Streicher, Elizabeth M.; Keyyu, Julius D.; Kendall, Sharon L.; Dockrell, Hazel M.; Michel, Anita L.; Rweyemamu, Mark M.; Warren, Robin M.; Matee, Mecky I.; van Helden, Paul D.; Couvin, David; Rastogi, Nalin

2016-01-01

The aim of this study was to assess and characterize Mycobacterium tuberculosis complex (MTBC) genotypic diversity in Tanzania, as well as in neighbouring East and other several African countries. We used spoligotyping to identify a total of 293 M. tuberculosis clinical isolates (one isolate per patient) collected in the Bunda, Dar es Salaam, Ngorongoro and Serengeti areas in Tanzania. The results were compared with results in the SITVIT2 international database of the Pasteur Institute of Guadeloupe. Genotyping and phylogeographical analyses highlighted the predominance of the CAS, T, EAI, and LAM MTBC lineages in Tanzania. The three most frequent Spoligotype International Types (SITs) were: SIT21/CAS1-Kili (n = 76; 25.94%), SIT59/LAM11-ZWE (n = 22; 7.51%), and SIT126/EAI5 tentatively reclassified as EAI3-TZA (n = 18; 6.14%). Furthermore, three SITs were newly created in this study (SIT4056/EAI5 n = 2, SIT4057/T1 n = 1, and SIT4058/EAI5 n = 1). We noted that the East-African-Indian (EAI) lineage was more predominant in Bunda, the Manu lineage was more common among strains isolated in Ngorongoro, and the Central-Asian (CAS) lineage was more predominant in Dar es Salaam (p-value<0.0001). No statistically significant differences were noted when comparing HIV status of patients vs. major lineages (p-value = 0.103). However, when grouping lineages as Principal Genetic Groups (PGG), we noticed that PGG2/3 group (Haarlem, LAM, S, T, and X) was more associated with HIV-positive patients as compared to PGG1 group (Beijing, CAS, EAI, and Manu) (p-value = 0.03). This study provided mapping of MTBC genetic diversity in Tanzania (containing information on isolates from different cities) and neighbouring East African and other several African countries highlighting differences as regards to MTBC genotypic distribution between Tanzania and other African countries. This work also allowed underlining of spoligotyping patterns tentatively grouped within the newly designated EAI3-TZA lineage (remarkable by absence of spacers 2 and 3, and represented by SIT126) which seems to be specific to Tanzania. However, further genotyping information would be needed to confirm this specificity. PMID:27149626

The Analog Computer as a Teaching Tool in Physics

ERIC Educational Resources Information Center

Wylen, H. E.; Schwarz, W. M.

1973-01-01

Discusses use of two EAI semi-expanded TR-20 units to display solutions to differential equations for harmonic oscillators, quantum-mechanical particles, trajectories, radioactive decay series, and hysteresis curves. Suggests practical applications for both undergraduate physics laboratories and classroom demonstrations. (CC)

Short communication: Field fertility in Holstein bulls: Can type of breeding strategy (artificial insemination following estrus versus timed artificial insemination) alter service sire fertility?

PubMed

Batista, E O S; Vieira, L M; Sá Filho, M F; Carvalho, P D; Rivera, H; Cabrera, V; Wiltbank, M C; Baruselli, P S; Souza, A H

2016-03-01

The aim of this study was to compare pregnancy per artificial insemination (P/AI) from service sires used on artificial insemination after estrus detection (EAI) or timed artificial insemination (TAI) breedings. Confirmed artificial insemination outcome records from 3 national data centers were merged and used as a data source. Criteria edits were herd's overall P/AI within 20 and 60%, a minimum of 30 breedings reported per herd-year, service sires that were used in at least 10 different herds with no more than 40% of the breedings performed in a single herd, breeding records from lactating Holstein cows receiving their first to fifth postpartum breedings occurring within 45 to 375 d in milk, and cows with 1 to 5 lactations producing a minimum of 6,804 kg. Initially 1,142,859 breeding records were available for analysis. After editing, a subset of the data (n=857,539) was used to classify breeding codes into either EAI or TAI based on weekly insemination profile in each individual herd. The procedure HPMIXED of SAS was used and took into account effects of state, farm, cow identification, breeding month, year, parity, days in milk at breeding, and service sire. This model was used independently for the 2 types osires f breeding codes (EAI vs. TAI), and service sire P/AI rankings within each breeding code were performed for sires with >700 breedings (94 sires) and for with >1,000 breedings (n=56 sires) following both EAI and TAI. Correlation for service sire fertility rankings following EAI and TAI was performed with the PROC CORR of SAS. Service sire P/AI rankings produced with EAI and TAI were 0.81 (for sires with >700 breedings) and 0.84 (for sires with >1,000 breedings). In addition, important changes occurred in service sire P/AI ranking to EAI and TAI for sires with less than 10,000 recorded artificial inseminations. In conclusion, the type of breeding strategy (EAI or TAI) was associated with some changes in service sire P/AI ranking, but ranking changes declined as number of breedings per service sire increased. Future randomized studies need to explore whether changes in P/AI ranking to EAI versus TAI are due to specific semen characteristics. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Validity and Reliability of Visual Analog Scaling for Assessment of Hypernasality and Audible Nasal Emission in Children With Repaired Cleft Palate.

PubMed

Baylis, Adriane; Chapman, Kathy; Whitehill, Tara L; Group, The Americleft Speech

2015-11-01

To investigate the validity and reliability of multiple listener judgments of hypernasality and audible nasal emission, in children with repaired cleft palate, using visual analog scaling (VAS) and equal-appearing interval (EAI) scaling. Prospective comparative study of multiple listener ratings of hypernasality and audible nasal emission. Multisite institutional. Five trained and experienced speech-language pathologist listeners from the Americleft Speech Project. Average VAS and EAI ratings of hypernasality and audible nasal emission/turbulence for 12 video-recorded speech samples from the Americleft Speech Project. Intrarater and interrater reliability was computed, as well as linear and polynomial models of best fit. Intrarater and interrater reliability was acceptable for both rating methods; however, reliability was higher for VAS as compared to EAI ratings. When VAS ratings were plotted against EAI ratings, results revealed a stronger curvilinear relationship. The results of this study provide additional evidence that alternate rating methods such as VAS may offer improved validity and reliability over EAI ratings of speech. VAS should be considered a viable method for rating hypernasality and nasal emission in speech in children with repaired cleft palate.

A Method for Transforming Existing Web Service Descriptions into an Enhanced Semantic Web Service Framework

NASA Astrophysics Data System (ADS)

Du, Xiaofeng; Song, William; Munro, Malcolm

Web Services as a new distributed system technology has been widely adopted by industries in the areas, such as enterprise application integration (EAI), business process management (BPM), and virtual organisation (VO). However, lack of semantics in the current Web Service standards has been a major barrier in service discovery and composition. In this chapter, we propose an enhanced context-based semantic service description framework (CbSSDF+) that tackles the problem and improves the flexibility of service discovery and the correctness of generated composite services. We also provide an agile transformation method to demonstrate how the various formats of Web Service descriptions on the Web can be managed and renovated step by step into CbSSDF+ based service description without large amount of engineering work. At the end of the chapter, we evaluate the applicability of the transformation method and the effectiveness of CbSSDF+ through a series of experiments.

Temporal Trends in Epinephrine Dispensing and Allergy/Immunology Follow-up Among Emergency Department Anaphylaxis Patients in the United States, 2005-2014.

PubMed

Motosue, Megan S; Bellolio, M Fernanda; Van Houten, Holly K; Shah, Nilay D; Bellamkonda, Venkatesh R; Nestler, David M; Campbell, Ronna L

Anaphylaxis is a potentially life-threatening allergic reaction; measures including prescription of an epinephrine autoinjector (EAI) and allergy/immunology (A/I) follow-up may prevent future morbidity. The objective of this study was to evaluate trends in outpatient management of anaphylaxis by studying EAI dispensing and A/I follow-up among patients seen in the emergency department (ED) for anaphylaxis from 2005 through 2014. We analyzed administrative claims data from the OptumLabs Data Warehouse database using an expanded International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code algorithm. The study cohort comprised 18,279 patients with a mean age of 39 years; 58% were female, and 86% were discharged from an ED. Within 1 year after discharge, 46% had filled an EAI prescription and 29% had A/I follow-up. Overall, from 2005 to 2014, annual rates of filled EAI prescriptions and A/I follow-up did not change. Among children (aged <18 years), rates increased for filled EAI prescriptions (16.1% increase; P = .02 for trend) and A/I follow-up (18.8% increase; P = .048 for trend). Rates decreased for A/I follow-up among adults (15.4% decrease; P = .002 for trend). Overall rates of filled EAI prescriptions were highest in those with venom-induced (73.9 per 100 ED visits) and food-induced anaphylaxis (69.4 per 100 ED visits); the lowest rates were among those with medication-related anaphylaxis (18.2 per 100 ED visits). Over the past decade, rates of EAI dispensing and A/I follow-up after an ED visit for anaphylaxis have remained low, suggesting that patients may not be prepared to manage future episodes. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Windblown Pliocene diatoms and East Antarctic Ice Sheet retreat

PubMed Central

Scherer, Reed P.; DeConto, Robert M.; Pollard, David; Alley, Richard B.

2016-01-01

Marine diatoms in tillites along the Transantarctic Mountains (TAMs) have been used to suggest a diminished East Antarctic Ice Sheet (EAIS) during Pliocene warm periods. Updated ice-sheet modelling shows significant Pliocene EAIS retreat, creating marine embayments into the Wilkes and Aurora basins that were conducive to high diatom productivity and rapid accumulation of diatomaceous sediments. Here we show that subsequent isostatic uplift exposed accumulated unconsolidated marine deposits to wind erosion. We report new atmospheric modelling utilizing Pliocene climate and derived Antarctic landscapes indicating that prevailing mid-altitude winds transported diatoms towards the TAMs, dominantly from extensive emerged coastal deposits of the Aurora Basin. This result unifies leading ideas from competing sides of a contentious debate about the origin of the diatoms in the TAMs and their link to EAIS history, supporting the view that parts of the EAIS are vulnerable to relatively modest warming, with possible implications for future sea-level rise. PMID:27649516

Microfluidic-Based Measurement Method of Red Blood Cell Aggregation under Hematocrit Variations

PubMed Central

2017-01-01

Red blood cell (RBC) aggregation and erythrocyte sedimentation rate (ESR) are considered to be promising biomarkers for effectively monitoring blood rheology at extremely low shear rates. In this study, a microfluidic-based measurement technique is suggested to evaluate RBC aggregation under hematocrit variations due to the continuous ESR. After the pipette tip is tightly fitted into an inlet port, a disposable suction pump is connected to the outlet port through a polyethylene tube. After dropping blood (approximately 0.2 mL) into the pipette tip, the blood flow can be started and stopped by periodically operating a pinch valve. To evaluate variations in RBC aggregation due to the continuous ESR, an EAI (Erythrocyte-sedimentation-rate Aggregation Index) is newly suggested, which uses temporal variations of image intensity. To demonstrate the proposed method, the dynamic characterization of the disposable suction pump is first quantitatively measured by varying the hematocrit levels and cavity volume of the suction pump. Next, variations in RBC aggregation and ESR are quantified by varying the hematocrit levels. The conventional aggregation index (AI) is maintained constant, unrelated to the hematocrit values. However, the EAI significantly decreased with respect to the hematocrit values. Thus, the EAI is more effective than the AI for monitoring variations in RBC aggregation due to the ESR. Lastly, the proposed method is employed to detect aggregated blood and thermally-induced blood. The EAI gradually increased as the concentration of a dextran solution increased. In addition, the EAI significantly decreased for thermally-induced blood. From this experimental demonstration, the proposed method is able to effectively measure variations in RBC aggregation due to continuous hematocrit variations, especially by quantifying the EAI. PMID:28878199

White Feather: Fire Control and Crosswind Sensing for Sniper Applications

DTIC Science & Technology

2008-06-01

EAI Corp. P. Smoak – Weaponeering Study update • 1998 • SBIRS – SCTi, Brimrose , and Optical Air o February – OST Review at Ft...GROUND MD 21005-5066 1 B T HUAG 2314 TITAN TERRACE HAVRE DE GRACE MD 21078 1 BRIMROSE CORP ATTN S KUTCHER 19 LOVETON CIRCLE BALTIMORE

Academic Difficulties Encountered by East Asian International University Students in New Zealand

ERIC Educational Resources Information Center

Lee, Boram; Farruggia, Susan P.; Brown, Gavin T. L.

2013-01-01

The study focused on learning difficulties experienced by East Asian International (EAI) students. Participants were 117 EAI students undertaking tertiary study at a major university, all were surveyed and 21 students were interviewed. The findings suggest that language limitations, academic content and learning styles were associated with…

Hybrid Computation at Louisiana State University.

ERIC Educational Resources Information Center

Corripio, Armando B.

Hybrid computation facilities have been in operation at Louisiana State University since the spring of 1969. In part, they consist of an Electronics Associates, Inc. (EAI) Model 680 analog computer, an EAI Model 693 interface, and a Xerox Data Systems (XDS) Sigma 5 digital computer. The hybrid laboratory is used in a course on hybrid computation…

The Private Management of Public Schools: The Baltimore, Maryland, Experience.

ERIC Educational Resources Information Center

Doughty, Sherri

In 1992 the Baltimore City Public School District (Maryland) entered into a 5-year contract with Education Alternatives, Incorporated (EAI), to manage 9 of its schools. Baltimore's private-management model differed significantly from that of Dade County, Florida, in that EAI was given overall management responsibility. Data were gathered through a…

Simulation Accelerator

NASA Technical Reports Server (NTRS)

1998-01-01

Under a NASA SBIR (Small Business Innovative Research) contract, (NAS5-30905), EAI Simulation Associates, Inc., developed a new digital simulation computer, Starlight(tm). With an architecture based on the analog model of computation, Starlight(tm) outperforms all other computers on a wide range of continuous system simulation. This system is used in a variety of applications, including aerospace, automotive, electric power and chemical reactors.

The Private Management of Public Schools: The Dade County, Florida, Experience.

ERIC Educational Resources Information Center

Edwards, Deborah Lawson

In 1990, the Dade County Public School System (DCPS) in Dade County, Florida, entered into a 5-year contract with a private company, Educational Alternatives Incorporated (EAI), to manage the educational services at South Pointe Elementary School. This paper presents findings of an evaluation of the DCPS-EAI collaboration at South Pointe. Data…

CMO: Cruise Metadata Organizer for JAMSTEC Research Cruises

NASA Astrophysics Data System (ADS)

Fukuda, K.; Saito, H.; Hanafusa, Y.; Vanroosebeke, A.; Kitayama, T.

2011-12-01

JAMSTEC's Data Research Center for Marine-Earth Sciences manages and distributes a wide variety of observational data and samples obtained from JAMSTEC research vessels and deep sea submersibles. Generally, metadata are essential to identify data and samples were obtained. In JAMSTEC, cruise metadata include cruise information such as cruise ID, name of vessel, research theme, and diving information such as dive number, name of submersible and position of diving point. They are submitted by chief scientists of research cruises in the Microsoft Excel° spreadsheet format, and registered into a data management database to confirm receipt of observational data files, cruise summaries, and cruise reports. The cruise metadata are also published via "JAMSTEC Data Site for Research Cruises" within two months after end of cruise. Furthermore, these metadata are distributed with observational data, images and samples via several data and sample distribution websites after a publication moratorium period. However, there are two operational issues in the metadata publishing process. One is that duplication efforts and asynchronous metadata across multiple distribution websites due to manual metadata entry into individual websites by administrators. The other is that differential data types or representation of metadata in each website. To solve those problems, we have developed a cruise metadata organizer (CMO) which allows cruise metadata to be connected from the data management database to several distribution websites. CMO is comprised of three components: an Extensible Markup Language (XML) database, an Enterprise Application Integration (EAI) software, and a web-based interface. The XML database is used because of its flexibility for any change of metadata. Daily differential uptake of metadata from the data management database to the XML database is automatically processed via the EAI software. Some metadata are entered into the XML database using the web-based interface by a metadata editor in CMO as needed. Then daily differential uptake of metadata from the XML database to databases in several distribution websites is automatically processed using a convertor defined by the EAI software. Currently, CMO is available for three distribution websites: "Deep Sea Floor Rock Sample Database GANSEKI", "Marine Biological Sample Database", and "JAMSTEC E-library of Deep-sea Images". CMO is planned to provide "JAMSTEC Data Site for Research Cruises" with metadata in the future.

Exercise addiction in CrossFit: Prevalence and psychometric properties of the Exercise Addiction Inventory.

PubMed

Lichtenstein, Mia Beck; Jensen, Tanja Tang

2016-06-01

CrossFit is a mix of aerobic and anaerobic exercise regimes with the stated goal of improving fitness and physical performance. It is growing in popularity and has a strong community known to motivate and push the participants to maximal performance. The negative consequences of these extreme exercise patterns have rarely been described. The prevalence of injuries in CrossFit is high but exercise addiction and harmful exercise attitudes have not yet been assessed. The aim of this study was to measure the prevalence of exercise addiction in CrossFit and to evaluate the reliability and validity of the Exercise Addiction Inventory (EAI) in a CrossFit population. We invited crossfitters to participate in an online survey using Facebook groups. A total of 603 regular crossfitters completed the EAI and additional questions concerning exercise amounts and negative exercise attitudes and beliefs. We used principal component analyses and structural equation models to test the psychometric properties of the EAI and to describe the characteristics of the addicted crossfitters. We found that 5% of the crossfitters were addicted to exercise and that young males had a higher risk. The EAI had good internal reliability (0.73) and construct validity. Thus we found significant positive associations between exercise addiction and the tendency to exercise in spite of injury, feelings of guilt when unable to exercise, passion turning into obsession and taking medication to be able to exercise. Exercise addiction is prevalent in CrossFit and needs further exploration. The EAI is recommended for research in CrossFit communities and applied settings.

Parent Perceptions of Psychosocial Outcomes of Equine-Assisted Interventions for Children with Autism Spectrum Disorder.

PubMed

Tan, Vanessa Xue-Ling; Simmonds, Janette Graetz

2018-03-01

This research explored parents' perceptions of the psychosocial outcomes of their children's experience of receiving equine-assisted interventions (EAI). Participants were the parents of six children (aged 3-14) diagnosed with autism spectrum disorder. Five semi-structured interviews were conducted and the transcript data was analysed using Interpretative phenomenological analysis. Four super-ordinate themes emerged from the analysis: (1) child's improved self-concept and enhanced emotional well-being, (2) child's improved self-regulatory ability, (3) social benefits for the child, and (4) unexpected outcomes. EAI was perceived by the parents as having several levels of psychosocial benefits for their children. These benefits may also extend to parents and family through ecopsychological and "flow on" effects associated with the children's involvement in EAI programs.

Initiation and long-term instability of the East Antarctic Ice Sheet.

PubMed

Gulick, Sean P S; Shevenell, Amelia E; Montelli, Aleksandr; Fernandez, Rodrigo; Smith, Catherine; Warny, Sophie; Bohaty, Steven M; Sjunneskog, Charlotte; Leventer, Amy; Frederick, Bruce; Blankenship, Donald D

2017-12-13

Antarctica's continental-scale ice sheets have evolved over the past 50 million years. However, the dearth of ice-proximal geological records limits our understanding of past East Antarctic Ice Sheet (EAIS) behaviour and thus our ability to evaluate its response to ongoing environmental change. The EAIS is marine-terminating and grounded below sea level within the Aurora subglacial basin, indicating that this catchment, which drains ice to the Sabrina Coast, may be sensitive to climate perturbations. Here we show, using marine geological and geophysical data from the continental shelf seaward of the Aurora subglacial basin, that marine-terminating glaciers existed at the Sabrina Coast by the early to middle Eocene epoch. This finding implies the existence of substantial ice volume in the Aurora subglacial basin before continental-scale ice sheets were established about 34 million years ago. Subsequently, ice advanced across and retreated from the Sabrina Coast continental shelf at least 11 times during the Oligocene and Miocene epochs. Tunnel valleys associated with half of these glaciations indicate that a surface-meltwater-rich sub-polar glacial system existed under climate conditions similar to those anticipated with continued anthropogenic warming. Cooling since the late Miocene resulted in an expanded polar EAIS and a limited glacial response to Pliocene warmth in the Aurora subglacial basin catchment. Geological records from the Sabrina Coast shelf indicate that, in addition to ocean temperature, atmospheric temperature and surface-derived meltwater influenced East Antarctic ice mass balance under warmer-than-present climate conditions. Our results imply a dynamic EAIS response with continued anthropogenic warming and suggest that the EAIS contribution to future global sea-level projections may be under-estimated.

Initiation and long-term instability of the East Antarctic Ice Sheet

NASA Astrophysics Data System (ADS)

Gulick, Sean P. S.; Shevenell, Amelia E.; Montelli, Aleksandr; Fernandez, Rodrigo; Smith, Catherine; Warny, Sophie; Bohaty, Steven M.; Sjunneskog, Charlotte; Leventer, Amy; Frederick, Bruce; Blankenship, Donald D.

2017-12-01

Antarctica’s continental-scale ice sheets have evolved over the past 50 million years. However, the dearth of ice-proximal geological records limits our understanding of past East Antarctic Ice Sheet (EAIS) behaviour and thus our ability to evaluate its response to ongoing environmental change. The EAIS is marine-terminating and grounded below sea level within the Aurora subglacial basin, indicating that this catchment, which drains ice to the Sabrina Coast, may be sensitive to climate perturbations. Here we show, using marine geological and geophysical data from the continental shelf seaward of the Aurora subglacial basin, that marine-terminating glaciers existed at the Sabrina Coast by the early to middle Eocene epoch. This finding implies the existence of substantial ice volume in the Aurora subglacial basin before continental-scale ice sheets were established about 34 million years ago. Subsequently, ice advanced across and retreated from the Sabrina Coast continental shelf at least 11 times during the Oligocene and Miocene epochs. Tunnel valleys associated with half of these glaciations indicate that a surface-meltwater-rich sub-polar glacial system existed under climate conditions similar to those anticipated with continued anthropogenic warming. Cooling since the late Miocene resulted in an expanded polar EAIS and a limited glacial response to Pliocene warmth in the Aurora subglacial basin catchment. Geological records from the Sabrina Coast shelf indicate that, in addition to ocean temperature, atmospheric temperature and surface-derived meltwater influenced East Antarctic ice mass balance under warmer-than-present climate conditions. Our results imply a dynamic EAIS response with continued anthropogenic warming and suggest that the EAIS contribution to future global sea-level projections may be under-estimated.

Amino acid composition and functional properties of giant red sea cucumber ( Parastichopus californicus) collagen hydrolysates

NASA Astrophysics Data System (ADS)

Liu, Zunying; Su, Yicheng; Zeng, Mingyong

2011-03-01

Giant red sea cucumber ( Parastichopus californicus) is an under-utilized species due to its high tendency to autolysis. The aim of this study was to evaluate the functional properties of collagen hydrolysates from this species. The degree of hydrolysis (DH), amino acid composition, SDS-PAGE, emulsion activity index (EAI), emulsion stability index (ESI), foam expansion (FE), and foam stability (FS) of hydrolysates were investigated. The effects of pH on the EAI, ESI FE and FS of hydrolysates were also investigated. The results indicated that the β and α 1 chains of the collagen were effectively hydrolyzed by trypsin at 50°c with an Enzyme/Substrate (E/S) ration of 1:20 (w:w). The DH of collagen was up to 17.3% after 3 h hydrolysis with trypsin. The hydrolysates had a molecular weight distribution of 1.1-17 kDa, and were abundant in glycine (Gly), proline (Pro), glutamic acid (Glu), alanine (Ala) and hydroxyproline (Hyp) residues. The hydrolysates were fractionated into three fractions (< 3 kDa, 3-10 kDa, and > 10 kDa), and the fraction of 3-10 kDa exhibited a higher EAI value than the fraction of > 10 kDa ( P<0.05). The fraction of > 10 kDa had higher FE and FS values than other fractions ( P<0.05). The pH had an important effect on the EAI, ESI, FE and FS. All the fractions showed undesirable emulsion and forming properties at pH 4.0. Under pH 7.0 and pH 10.0, the 3-10 kDa fraction showed higher EAI value and the fraction of > 10 kDa showed higher FE value, respectively. They are hoped to be utilized as functional ingredients in food and nutraceutical industries.

Analyzing the Web Services and UniFrame Paradigms

DTIC Science & Technology

2003-04-01

paradigm from a centralized one to a distributed one. Hence, the target environment is no more a centrally managed, but concerned with collaboration...lever (business logic level) and provide a new platform to build software for a distributed environment . UniFrame is a research project that aims to...EAI solutions provide tends to be complex and expensive, despite improving the overall communication. In addition, the EAI interfaces are not reusable

Extreme decay of meteoric beryllium-10 as a proxy for persistent aridity.

PubMed

Valletta, Rachel D; Willenbring, Jane K; Lewis, Adam R; Ashworth, Allan C; Caffee, Marc

2015-12-09

The modern Antarctic Dry Valleys are locked in a hyper-arid, polar climate that enables the East Antarctic Ice Sheet (EAIS) to remain stable, frozen to underlying bedrock. The duration of these dry, cold conditions is a critical prerequisite when modeling the long-term mass balance of the EAIS during past warm climates and is best examined using terrestrial paleoclimatic proxies. Unfortunately, deposits containing such proxies are extremely rare and often difficult to date. Here, we apply a unique dating approach to tundra deposits using concentrations of meteoric beryllium-10 ((10)Be) adhered to paleolake sediments from the Friis Hills, central Dry Valleys. We show that lake sediments were emplaced between 14-17.5 My and have remained untouched by meteoric waters since that time. Our results support the notion that the onset of Dry Valleys aridification occurred ~14 My, precluding the possibility of EAIS collapse during Pliocene warming events. Lake fossils indicate that >14 My ago the Dry Valleys hosted a moist tundra that flourished in elevated atmospheric CO2 (>400 ppm). Thus, Dry Valleys tundra deposits record regional climatic transitions that affect EAIS mass balance, and, in a global paleoclimatic context, these deposits demonstrate how warming induced by 400 ppm CO2 manifests at high latitudes.

Extreme decay of meteoric beryllium-10 as a proxy for persistent aridity

PubMed Central

Valletta, Rachel D.; Willenbring, Jane K.; Lewis, Adam R.; Ashworth, Allan C.; Caffee, Marc

2015-01-01

The modern Antarctic Dry Valleys are locked in a hyper-arid, polar climate that enables the East Antarctic Ice Sheet (EAIS) to remain stable, frozen to underlying bedrock. The duration of these dry, cold conditions is a critical prerequisite when modeling the long-term mass balance of the EAIS during past warm climates and is best examined using terrestrial paleoclimatic proxies. Unfortunately, deposits containing such proxies are extremely rare and often difficult to date. Here, we apply a unique dating approach to tundra deposits using concentrations of meteoric beryllium-10 (10Be) adhered to paleolake sediments from the Friis Hills, central Dry Valleys. We show that lake sediments were emplaced between 14–17.5 My and have remained untouched by meteoric waters since that time. Our results support the notion that the onset of Dry Valleys aridification occurred ~14 My, precluding the possibility of EAIS collapse during Pliocene warming events. Lake fossils indicate that >14 My ago the Dry Valleys hosted a moist tundra that flourished in elevated atmospheric CO2 (>400 ppm). Thus, Dry Valleys tundra deposits record regional climatic transitions that affect EAIS mass balance, and, in a global paleoclimatic context, these deposits demonstrate how warming induced by 400 ppm CO2 manifests at high latitudes. PMID:26647733

Bedrock Erosion Surfaces Record Former East Antarctic Ice Sheet Extent

NASA Astrophysics Data System (ADS)

Paxman, Guy J. G.; Jamieson, Stewart S. R.; Ferraccioli, Fausto; Bentley, Michael J.; Ross, Neil; Armadillo, Egidio; Gasson, Edward G. W.; Leitchenkov, German; DeConto, Robert M.

2018-05-01

East Antarctica hosts large subglacial basins into which the East Antarctic Ice Sheet (EAIS) likely retreated during past warmer climates. However, the extent of retreat remains poorly constrained, making quantifying past and predicted future contributions to global sea level rise from these marine basins challenging. Geomorphological analysis and flexural modeling within the Wilkes Subglacial Basin are used to reconstruct the ice margin during warm intervals of the Oligocene-Miocene. Flat-lying bedrock plateaus are indicative of an ice sheet margin positioned >400-500 km inland of the modern grounding zone for extended periods of the Oligocene-Miocene, equivalent to a 2-m rise in global sea level. Our findings imply that if major EAIS retreat occurs in the future, isostatic rebound will enable the plateau surfaces to act as seeding points for extensive ice rises, thus limiting extensive ice margin retreat of the scale seen during the early EAIS.

Mycobacterium tuberculosis lineages and anti-tuberculosis drug resistance in reference hospitals across Viet Nam.

PubMed

Nguyen, Van Anh Thi; Bañuls, Anne-Laure; Tran, Thanh Hoa Thi; Pham, Kim Lien Thi; Nguyen, Thai Son; Nguyen, Hung Van; Nguyen, Ngoc Lan Thi; Nguyen, Nam Lien Thi; Dang, Duc Anh; Marks, Guy B; Choisy, Marc

2016-07-28

Mycobacterium tuberculosis, the tuberculosis (TB) pathogen, despite a low level of genetic diversity, has revealed a high variety of biological and epidemiological characteristics linked to their lineages, such as transmissibility, fitness and propensity to acquire drug resistance. This has important implications for the epidemiology of TB. We conducted this first countrywide cross-sectional study to identify the prevalent M. tuberculosis lineages and to assess their epidemiological associations and their relation to drug resistance. The study was conducted among isolates acquired in reference hospitals across Vietnam. Isolates with drug susceptibility testing profiles were identified for their lineages by spoligotyping. Logistic regression was used to investigate the association of M. tuberculosis lineages with location, age and sex of the patients and drug resistance levels. Results showed that the most prevalent lineage was Beijing (55.4 %), followed by EAI (27.5 %), T (6.4 %), LAM (1.3 %), Haarlem (1 %) and Zero type (0.3 %). The proportion of Beijing isolates in the North (70.4 %) and the South (68 %) was higher than in the Centre (28 %) (OR = 1.7 [95 % CI: 1.4-2.0], p < 0.0001), whereas the proportion of EAI isolates in the North (7.1 %) and the South (17 %) was much lower compared with the Centre (59 %) (OR = 0.5 [95 % CI: 0.4-0.6], p < 0.0001). Overall, Beijing isolates were the most likely to be drug-resistant and EAI isolates were the least likely to be drug-resistant, except in the South of Vietnam where EAI is also highly drug-resistant. The proportion of Beijing isolates was significantly higher (p < 0.01), and the proportion of EAI isolates was significantly lower (p < 0.05) in younger patients. The proportion of drug-resistance was higher in isolates collected from male patients and from patients in the middle age groups. The findings suggest ongoing replacement of EAI lineage, which is mainly more drug-susceptible with highly drug-resistant Beijing lineage in all studied regions of Vietnam. Male patients of working ages should be the focus for better control to prevent the emergence of drug-resistant TB.

A Web-based cost-effective training tool with possible application to brain injury rehabilitation.

PubMed

Wang, Peijun; Kreutzer, Ina Anna; Bjärnemo, Robert; Davies, Roy C

2004-06-01

Virtual reality (VR) has provoked enormous interest in the medical community. In particular, VR offers therapists new approaches for improving rehabilitation effects. However, most of these VR assistant tools are not very portable, extensible or economical. Due to the vast amount of 3D data, they are not suitable for Internet transfer. Furthermore, in order to run these VR systems smoothly, special hardware devices are needed. As a result, existing VR assistant tools tend to be available in hospitals but not in patients' homes. To overcome these disadvantages, as a case study, this paper proposes a Web-based Virtual Ticket Machine, called WBVTM, using VRML [VRML Consortium, The Virtual Reality Modeling Language: International Standard ISO/IEC DIS 14772-1, 1997, available at ], Java and EAI (External Authoring Interface) [Silicon Graphics, Inc., The External Authoring Interface (EAI), available at ], to help people with acquired brain injury (ABI) to relearn basic living skills at home at a low cost. As these technologies are open standard and feature usability on the Internet, WBVTM achieves the goals of portability, easy accessibility and cost-effectiveness.

Training Chrysalis: Applications of Special Forces Training in the Development of the Objective Force

DTIC Science & Technology

2003-06-06

refers constantly to an “adaptive enemy,” that is, one that will ferret out, analyze , and then exploit weaknesses within the OF systems , technologies...Department of the Army EAI Executive Agent Instruction FCS Future Combat System FTX Field Training Exercise G-chief Guerrilla Chief, leader of an...and lighter Army battle platforms will still have greater lethality and survivability than current systems . The information revolution will be

Improvement of Functional Properties of Wheat Gluten Using Acid Protease from Aspergillus usamii

PubMed Central

Deng, Lingli; Wang, Zhaoxia; Yang, Sheng; Song, Junmei; Que, Fei; Zhang, Hui; Feng, Fengqin

2016-01-01

Hydrolysis parameters (temperature, E/S ratio, pH, and time) for acid protease (from Aspergillus usamii) hydrolysis of wheat gluten were optimized by response surface methodology (RSM) using emulsifying activity index (EAI) as the response factor. A temperature of 48.9°C, E/S ratio of 1.60%, pH 3.0, hydrolysis time of 2.5 h was found to be the optimum condition to obtain wheat gluten hydrolysate with higher EAI. The solubility of wheat gluten was greatly improved by hydrolysis and became independent of pH over the studied range. Enzymatic hydrolysis resulted in dramatically increase in EAI, water and oil holding capacity. Molecular weight distribution results showed that most of the peptides above 10 kDa have been hydrolyzed into smaller peptides. The results of FTIR spectra and disulfide bond (SS) and sulfhydryl (SH) content suggested that a more extensional conformation was formed after hydrolysis, which could account for the improved functional properties. PMID:27467884

Improvement of Functional Properties of Wheat Gluten Using Acid Protease from Aspergillus usamii.

PubMed

Deng, Lingli; Wang, Zhaoxia; Yang, Sheng; Song, Junmei; Que, Fei; Zhang, Hui; Feng, Fengqin

2016-01-01

Hydrolysis parameters (temperature, E/S ratio, pH, and time) for acid protease (from Aspergillus usamii) hydrolysis of wheat gluten were optimized by response surface methodology (RSM) using emulsifying activity index (EAI) as the response factor. A temperature of 48.9°C, E/S ratio of 1.60%, pH 3.0, hydrolysis time of 2.5 h was found to be the optimum condition to obtain wheat gluten hydrolysate with higher EAI. The solubility of wheat gluten was greatly improved by hydrolysis and became independent of pH over the studied range. Enzymatic hydrolysis resulted in dramatically increase in EAI, water and oil holding capacity. Molecular weight distribution results showed that most of the peptides above 10 kDa have been hydrolyzed into smaller peptides. The results of FTIR spectra and disulfide bond (SS) and sulfhydryl (SH) content suggested that a more extensional conformation was formed after hydrolysis, which could account for the improved functional properties.

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.

PubMed

Xie, Liang; Duncan, Michael B; Pahler, Jessica; Sugimoto, Hikaru; Martino, Margot; Lively, Julie; Mundel, Thomas; Soubasakos, Mary; Rubin, Kristofer; Takeda, Takaaki; Inoue, Masahiro; Lawler, Jack; Hynes, Richard O; Hanahan, Douglas; Kalluri, Raghu

2011-06-14

Whereas the roles of proangiogenic factors in carcinogenesis are well established, those of endogenous angiogenesis inhibitors (EAIs) remain to be fully elaborated. We investigated the roles of three EAIs during de novo tumorigenesis to further test the angiogenic balance hypothesis, which suggests that blood vessel development in the tumor microenvironment can be governed by a net loss of negative regulators of angiogenesis in addition to the well-established principle of up-regulated angiogenesis inducers. In a mouse model of pancreatic neuroendocrine cancer, administration of endostatin, thrombospondin-1, and tumstatin peptides, as well as deletion of their genes, reveal neoplastic stage-specific effects on angiogenesis, tumor progression, and survival, correlating with endothelial expression of their receptors. Deletion of tumstatin and thrombospondin-1 in mice lacking the p53 tumor suppressor gene leads to increased incidence and reduced latency of angiogenic lymphomas associated with diminished overall survival. The results demonstrate that EAIs are part of a balance mechanism regulating tumor angiogenesis, serving as intrinsic microenvironmental barriers to tumorigenesis.

Use of questionnaires and an expert panel to judge the environmental consequences of chemical spills for the development of an environment-accident index.

PubMed

Andersson, Asa Scott; Stjernström, Olof; Fängmark, Ingrid

2005-05-01

Assessing the environmental consequences of a chemical accident is a complex task. To date, the methods used to evaluate the environmental effects of an acute release of a chemical have often been based on measurements of chemical and physical variables deemed to be important, such as the concentration of the chemical. However, a broader strategy is needed to predict the environmental consequences of potential accidents during the planning process. An Environment-Accident Index (EAI), a simple tool based on such a strategy, has been developed to facilitate the consideration of a multitude of influential variables. The objectives of this study were to evaluate whether questionnaire-based expert panel's judgements could provide useful data on the environmental consequences of chemical spills, and an effective basis for further development of the EAI. As expected, the judgements did not agree perfectly, but they do give rough indications of the environmental effects, and highlight consistent trends that should be useful inputs for planning, prevention and decontamination processes. The different accidents were also judged to have caused everything from minor to very major effects in the environment, implying that a wide range of accident scenarios were represented in the material and covered by the EAI. Therefore, questionnaires and expert panel judgements can be used to collect useful data for estimating the likely environmental consequences of chemical accidents and for further development of the EAI.

The Regionally-Oriented National Schools, an Innovative Tool for National and Regional Security Building

DTIC Science & Technology

2012-04-04

General Military Training CSID Cours Supérieur Interarmées de Défense Advanced Joint Services Defense Course 2008 EEML Ecole d’Etat-Major de...201271 ACRONYM FRENCH NAME ENGLISH TRANSLATION CAOG Cours d’Application des Officiers de Gendarmerie Gendarmerie Officers Training Course CPADD...Maintien de l’Ordre Law Enforcement Training Centre CSID Cours Supérieur Interarmées de Défense Advanced Joint Services Defense Course EAI Ecole

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neumann, Scott; Britton, Jay; Devos, Arnold N.

There are many uses for the Common Information Model (CIM), an ontology that is being standardized through Technical Committee 57 of the International Electrotechnical Commission (IEC TC57). The most common uses to date have included application modeling, information exchanges, information management and systems integration. As one should expect, there are many issues that become apparent when the CIM ontology is applied to any one use. Some of these issues are shortcomings within the current draft of the CIM, and others are a consequence of the different ways in which the CIM can be applied using different technologies. As the CIMmore » ontology will and should evolve, there are several dangers that need to be recognized. One is overall consistency and impact upon applications when extending the CIM for a specific need. Another is that a tight coupling of the CIM to specific technologies could limit the value of the CIM in the longer term as an ontology, which becomes a larger issue over time as new technologies emerge. The integration of systems is one specific area of interest for application of the CIM ontology. This is an area dominated by the use of XML for the definition of messages. While this is certainly true when using Enterprise Application Integration (EAI) products, it is even more true with the movement towards the use of Web Services (WS), Service-Oriented Architectures (SOA) and Enterprise Service Buses (ESB) for integration. This general IT industry trend is consistent with trends seen within the IEC TC57 scope of power system management and associated information exchange. The challenge for TC57 is how to best leverage the CIM ontology using the various XML technologies and standards for integration. This paper will provide examples of how the CIM ontology is used and describe some specific issues that should be addressed within the CIM in order to increase its usefulness as an ontology. It will also describe some of the issues and challenges that will be faced as the CIM ontology is leveraged for integration purposes by IEC TC57 standards.« less

Glacio-isostasy and Glacial Ice Load at Law Dome, Wilkes Land, East Antarctica

NASA Astrophysics Data System (ADS)

Goodwin, Ian D.; Zweck, Christopher

2000-05-01

The Holocene sea-level high stand or "marine limit" in Wilkes Land, East Antarctica, reached ˜30 m above present sea level at a few dispersed sites. The most detailed marine limit data have been recorded for the Windmill Islands and Budd Coast at the margin of the Law Dome ice cap, a dome of the East Antarctic Ice Sheet (EAIS). Relative sea-level lowering of 30 m and the associated emergence of the Windmill Islands have occurred since 6900 14C (corr.) yr B.P. Numerical modeling of the Earth's rheology is used to determine the glacio-isostatic component of the observed relative sea-level lowering. Glaciological evidence suggests that most of EAIS thickening occurred around its margin, with expansion onto the continental shelf. Consequently, a regional ice history for the last glacial maximum (LGM) was applied in the glacio-isostatic modeling to test whether the observed relative sea-level lowering was primarily produced by regional ice-sheet changes. The results of the modeling indicate that the postglacial (13,000 to 8000 14C yr B.P) removal of an ice load of between 770 and 1000 m from around the margin of the Law Dome and adjacent EAIS have produced the observed relative sea-level lowering. Such an additional ice load would have been associated with a 40- to 65-km expansion of the Law Dome to near the continental shelf break, together with a few hundred meters of ice thickening on the adjoining coastal slope of the EAIS up to 2000 m elevation. Whereas the observed changes in relative sea level are shown to be strongly influenced by regional ice sheet changes, the glacio-isostatic response at the Windmill Islands results from a combination of regional and, to a lesser extent, Antarctic-wide effects. The correspondence between the Holocene relative sea-level lowering interpreted at the margin of the Law Dome and the lowering interpreted along the remainder of the Wilkes Land and Oates Land coasts (105°-160° E) suggests that a similar ice load of up to 1000 m existed along the EAIS margin between Wilkes Land and Oates Land.

Exercise addiction in adolescents and emerging adults - Validation of a youth version of the Exercise Addiction Inventory.

PubMed

Lichtenstein, Mia Beck; Griffiths, Mark D; Hemmingsen, Simone Daugaard; Støving, René Klinkby

2018-03-01

Background Behavioral addictions often onset in adolescence and increase the risk of psychological and social problems later in life. The core symptoms of addiction are tolerance, withdrawal symptoms, lack of control, and compulsive occupation with the behavior. Psychometrically validated tools are required for detection and early intervention. Adolescent screening instruments exist for several behavioral addictions including gambling and video gaming addiction but not for exercise addiction. Given recent empirical and clinical evidence that a minority of teenagers appear to be experiencing exercise addiction, a psychometrically robust screening instrument is required. Aims The aim of this study was to develop and test the psychometric properties of a youth version of the Exercise Addiction Inventory (EAI) - a robust screening instrument that has been used across different countries and cultures - and to assess the prevalence of exercise addiction and associated disturbed eating. Methods A cross-sectional survey was administered to three high-risk samples (n = 471) aged 11-20 years (mean age: 16.3 years): sport school students, fitness center attendees, and patients with eating disorder diagnoses. A youth version of the EAI (EAI-Y) was developed and distributed. Participants were also screened for disordered eating with the SCOFF Questionnaire. Results Overall, the EAI-Y demonstrated good reliability and construct validity. The prevalence rate of exercise addiction was 4.0% in school athletes, 8.7% in fitness attendees, and 21% in patients with eating disorders. Exercise addiction was associated with feelings of guilt when not exercising, ignoring pain and injury, and higher levels of body dissatisfaction.

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

PubMed Central

Xie, Liang; Duncan, Michael B.; Pahler, Jessica; Sugimoto, Hikaru; Martino, Margot; Lively, Julie; Mundel, Thomas; Soubasakos, Mary; Rubin, Kristofer; Takeda, Takaaki; Inoue, Masahiro; Lawler, Jack; Hynes, Richard O.; Hanahan, Douglas; Kalluri, Raghu

2011-01-01

Whereas the roles of proangiogenic factors in carcinogenesis are well established, those of endogenous angiogenesis inhibitors (EAIs) remain to be fully elaborated. We investigated the roles of three EAIs during de novo tumorigenesis to further test the angiogenic balance hypothesis, which suggests that blood vessel development in the tumor microenvironment can be governed by a net loss of negative regulators of angiogenesis in addition to the well-established principle of up-regulated angiogenesis inducers. In a mouse model of pancreatic neuroendocrine cancer, administration of endostatin, thrombospondin-1, and tumstatin peptides, as well as deletion of their genes, reveal neoplastic stage-specific effects on angiogenesis, tumor progression, and survival, correlating with endothelial expression of their receptors. Deletion of tumstatin and thrombospondin-1 in mice lacking the p53 tumor suppressor gene leads to increased incidence and reduced latency of angiogenic lymphomas associated with diminished overall survival. The results demonstrate that EAIs are part of a balance mechanism regulating tumor angiogenesis, serving as intrinsic microenvironmental barriers to tumorigenesis. PMID:21622854

An automated procedure for calculating system matrices from perturbation data generated by an EAI Pacer and 100 hybrid computer system

NASA Technical Reports Server (NTRS)

Milner, E. J.; Krosel, S. M.

1977-01-01

Techniques are presented for determining the elements of the A, B, C, and D state variable matrices for systems simulated on an EAI Pacer 100 hybrid computer. An automated procedure systematically generates disturbance data necessary to linearize the simulation model and stores these data on a floppy disk. A separate digital program verifies this data, calculates the elements of the system matrices, and prints these matrices appropriately labeled. The partial derivatives forming the elements of the state variable matrices are approximated by finite difference calculations.

Integrated, flexible, and rapid geophysical surveying

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, S.F.; McGinnis, L.D.; Thompson, M.D.

1993-01-01

Aberdeen Proving Ground (APG), in the state of Maryland (Figure 1), is currently managing a comprehensive Installation Restoration Program involving more than 360 solid-waste managing units contained within 13 study areas. The Edgewood area and two landfills in the Aberdeen area appear on the National Priority List under the Comprehensive Environmental Response, Compensation, and Liability Act. Therefore, APG has entered into an interagency agreement with the US Environmental Protection Agency to address the listed areas. The West Branch of the Canal Creek area (Figure 1), located within the Edgewood area, is one of the areas that requires a Source Definitionmore » Study because there is an ongoing release of volatile organic compounds into the creek. A report prepared by EAI Corporation (1989) included a list of 29 potentially contaminated buildings in the Edgewood area. Sixteen of the buildings contain known contaminants, nine buildings contain unknown contaminants, and four of the buildings are potentially clean. The EAI report recommended that a sampling and monitoring program be established to verify contamination levels in and around each building. Thirteen of the potentially contaminated buildings are in the West Branch of the Canal Creek area and are potential sources of volatile organic compounds. Operations have ceased and the buildings have been abandoned, but processing equipment, sumps, drains, ventilation systems, and underground storage tanks remain. These appurtenances may contain liquid, solid, or vapor contaminants of unknown nature.« less

Integrated, flexible, and rapid geophysical surveying

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, S.F.; McGinnis, L.D.; Thompson, M.D.

1993-03-01

Aberdeen Proving Ground (APG), in the state of Maryland (Figure 1), is currently managing a comprehensive Installation Restoration Program involving more than 360 solid-waste managing units contained within 13 study areas. The Edgewood area and two landfills in the Aberdeen area appear on the National Priority List under the Comprehensive Environmental Response, Compensation, and Liability Act. Therefore, APG has entered into an interagency agreement with the US Environmental Protection Agency to address the listed areas. The West Branch of the Canal Creek area (Figure 1), located within the Edgewood area, is one of the areas that requires a Source Definitionmore » Study because there is an ongoing release of volatile organic compounds into the creek. A report prepared by EAI Corporation (1989) included a list of 29 potentially contaminated buildings in the Edgewood area. Sixteen of the buildings contain known contaminants, nine buildings contain unknown contaminants, and four of the buildings are potentially clean. The EAI report recommended that a sampling and monitoring program be established to verify contamination levels in and around each building. Thirteen of the potentially contaminated buildings are in the West Branch of the Canal Creek area and are potential sources of volatile organic compounds. Operations have ceased and the buildings have been abandoned, but processing equipment, sumps, drains, ventilation systems, and underground storage tanks remain. These appurtenances may contain liquid, solid, or vapor contaminants of unknown nature.« less

Geochemistry of East Antarctic Margin Sediments Spanning the Eocene Oligocene Transition.

NASA Astrophysics Data System (ADS)

Light, J. J.; Passchier, S.

2016-12-01

The Eocene Oligocene Transition (EOT) 34 million years ago (Ma), marked the global climate change from greenhouse to icehouse, and the full establishment of the East Antarctic Ice Sheet (EAIS). The initiation of the EAIS during the EOT is believed to have been a step-wise transition; however, data resolution is low and merits the need for further study. The purpose of this study is to expand upon existing knowledge of EAIS dynamics spanning the EOT by creating a higher resolution geochemical record of cores taken from continental shelf sites 1166 in Prydz Bay and U1360 from the Wilkes Land margin. We used Inductively Coupled Plasma Optical Emission Spectrometry and Mass Spectrometry (ICP-OES/ ICP-MS) to determine the bulk chemical composition of samples. Results were used to calculate the Chemical Index of Alteration (CIA), Al2O3/TiO2 ratios, and trace elemental variation down core. CIA values for the early Oligocene in Site U1360 indicate an arid colder environment less likely to be chemically weathered. In contrast, Hole 1166A shows values similar to average shales that increase up core and abruptly decrease at the overlying Neogene diamict, suggesting a warmer more humid environment at Prydz Bay during the late Eocene. Al2O3/TiO2 ratios were used to evaluate mud provenance changes at each site. At site 1166 redox sensitive elements (Cr, Ni, and V) show similar down core distributions to one another. The changes in elemental intensities are likely being controlled by factors such as sediment provenance, changes in redox conditions and surficial weathering. We expect the outcomes of this study to allow us to interpret regional depositional environments at a higher resolution, as well as to shed light on the EAIS's step-wise initiation.

New Collaborative Aerogeophysical Survey Targets the Stability of the East Antarctic Ice sheet and its Geological Boundary Conditions

NASA Astrophysics Data System (ADS)

Ferraccioli, F.; Corr, H.; Jordan, T.; Bozzo, E.; Armadillo, E.; Caneva, G.; Frearson, N.; Robinson, C.; Smellie, J.

2006-12-01

At the eve of the IPY large aerogeophysical survey data gaps still remain over the East Antarctic Ice Sheet (EAIS). This is due to the logistic and environmental challenges involved in exploration over these areas. During the 2005/06 Antarctic field season the British Antarctic Survey (BAS) collaborated with the University of Genoa to accomplish an extensive airborne geophysical survey over the EAIS. We explored the enigmatic Wilkes Subglacial Basin (WSB) and the adjacent Transantarctic Mountains (TAM). Over 60,000-line km of new data were collected during 70 survey flights. 270 hours of dedicated science flying and 45 hours of positioning and calibration flying were performed. The Italian Antarctic Programme provided the logistic support and aviation fuel at Mario Zucchelli Station, Mid-Point, and at two remote field camps, Talos Dome and Sitry. Additional support and fuel was provided at Dome C, as part of a separate trilateral UK/Italian and French agreement to survey some of the subglacial lakes, which characterise this region. The airborne survey platform was a BAS Twin Otter, equipped with airborne radar, aeromagnetic and airborne gravity sensors. We present key new datasets on ice surface, ice thickness, bedrock configurations, airborne gravity and aeromagnetic anomalies. These new data will assist in addressing four major open questions: 1) Are there Cenozoic marine sediments in the WSB, linked to controversial deglaciation over this part of the EAIS?; 2) What is the tectonic origin and deep structure of the WSB and TAM?; 3) Is there major segmentation of the TAM?, 4) what forcings and feedbacks were involved for the EAIS and for climate evolution?.

Green, Yellow, and Red risk perception in everyday life - a communication tool.

PubMed

Stensgaard, A; DunnGalvin, A; Nielsen, D; Munch, M; Bindslev-Jensen, C

2017-07-01

Adolescents have the highest risk for food allergy-related fatalities. Our main aim was to investigate the level of risk in everyday social situations as perceived by adolescents/young adults with peanut allergy, their families, and their friends. The web-based 'Colours Of Risks' (COR) questionnaire was completed by 70 patients (aged 12-23 years), 103 mothers and fathers, 31 siblings (aged 12-26 years), and 42 friends (aged 12-24 years). COR deals with six main contexts (home, school/university, work, visiting/social activities, special occasions/parties, and vacations), each with 1-12 items. Response categories are green (I feel safe), yellow (I feel uncertain), or red (I feel everything is risky). There was a high level of agreement between participants in defining situations as safe, uncertain, or risky, but female patients and mothers rated fewer situations as safe compared to male patients and fathers. Being with close friends and family, and attending planned parties without alcohol were perceived as situations of low risk. While 94% of patients took an epinephrine auto-injector (EAI) into risky situations, only 65% took it into safe situations. In contrast to the close family, 31% of the friends did not know the patient had an EAI, and fewer knew how to administer the EAI. Young adults with peanut allergy face challenges when moving from the safe home with ready assistance if needed, to independence with unpredictable surroundings and less certain help. Perceived 'safe' situations may in fact be the riskiest, as patients often do not take the EAI with them. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Basic Life Support Access to Injectable Epinephrine across the United States.

PubMed

Brasted, Ian D; Dailey, Michael W

2017-01-01

 Aggressive epinephrine administration has growing support in the treatment of anaphylaxis, a life-threatening allergic reaction. Emergency Medical Services (EMS) providers are frequently in a position to provide the first care to someone experiencing an anaphylactic reaction. Intramuscular injection of epinephrine is the definitive pharmacologic treatment for many associated symptoms. While easy to use, epinephrine autoinjectors (EAI) are prohibitively expensive, having increased in price ten-fold in ten years. Some states and EMS departments have begun expanding the scope of practice to allow Basic Life Support (BLS) providers, previously restricted to noninvasive therapies, to administer epinephrine by syringe. To compile a current and comprehensive list of how epinephrine is carried and used by EMS across the USA. An online survey focusing on anaphylaxis protocols and epinephrine administration was sent to state EMS medical directors and officials in all 50 states. Follow-up telephone calls were made to ensure compliance. Data were analyzed with descriptive statistics. Forty-nine of the 50 states in the USA provided a survey response. Texas responded but declined to participate in the survey because of practice variability across the state. In the other states, the form of epinephrine allowed or required on BLS ambulances was consistent with the scope of practice of their Basic Emergency Medical Technician (EMT). Thirteen states had training programs to allow BLS providers to inject epinephrine; 7 were considering it; 29 were not. Twenty-seven states specified EAI as the only form of epinephrine required or allowed on their BLS ambulances. No states reported allowing any level of EMS provider below EMT to use alternatives to EAI. This study confirms that many states have expanded the training of BLS providers to include the use of syringe injectable epinephrine. Even so, the majority of states relied on EAI in BLS ambulances.

Acacia gum as modifier of thermal stability, solubility and emulsifying properties of α-lactalbumin.

PubMed

de Oliveira, Fabíola Cristina; Dos Reis Coimbra, Jane Sélia; de Oliveira, Eduardo Basílio; Rodrigues, Marina Quadrio Raposo Branco; Sabioni, Rachel Campos; de Souza, Bartolomeu Warlene Silva; Santos, Igor José Boggione

2015-03-30

Protein-polysaccharide conjugates often display improved techno-functional properties when compared to their individual involved biomolecules. α-Lactalbumin:acacia gum (α-la:AG) conjugates were prepared via Maillard reaction by the dry-heating method. Conjugate formation was confirmed using results of absorbance, o-phthalaldehyde test, sodium dodecyl sulfate-polyacrilamide gel electrophoresis (SDS-PAGE) and size exclusion chromatography. Techno-functional properties (emulsifying characteristics, solubility, and thermal stability) were evaluated for α-la, α-la/AG mixtures and α-la:AG conjugates. Conjugate thermal stability was improved compared to pure α-la treated at the same conditions of conjugate formation. Response surface methodology was used to establish models to predict solubility and emulsifying activity as functions of the salt concentration, pH and reaction time. α-la:AG conjugate solubility is affected in a complex manner by the three factors analyzed. Emulsifying activity index (EAI) of α-la is significantly affected by pH, while the α-la:AG EAI is affected by the three analyzed factors. Both solubility and EAI are maximized with pH 8.0, NaCl concentration of 0.3 mol L(-1) and two days of Maillard reaction. Copyright © 2014 Elsevier Ltd. All rights reserved.

Being in-between: A model of cultural identity negotiation for emerging adult immigrants.

PubMed

Cohen, Julie A; Kassan, Anusha

2018-03-01

This qualitative study explored the cultural identity negotiation of young adult immigrants. Using a grounded theory research design, 10 semistructured interviews were conducted with emerging adult immigrants (EAI), ages 19-27. Results yielded a substantive model of cultural identity negotiation (MCIN) for EAI and posited that One's Motivation and Sense of Agency to Negotiate Cultural Identity is at the core of how participants navigate their cultural identities. This model included 6 major categories: (a) Family Cultural Rigidity ; (b) Connections Specific to Canada ; (c) Connection to a Same Cultured Community ; (d) Sense of Permanency ; (e) Desire to Preserve Culture of Origin ; (f) Desire to Fit in to Canadian Culture , as well as 2 overarching factors ( Dimension of Time and Dimension of Age ), which were found to be influential on participants' cultural identity negotiation. The model also included the identification of 4 approaches to cultural identity negotiation: (a) Blended; (b) Dual; (c) Disconnected; and (d) Intermediate. The MCIN for EAI is discussed in terms of the current literature on cultural identity formation as well as implications for counseling psychology training and practice. Recommendations for further research are also suggested. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Testing the psychometric properties of the Environmental Attitudes Inventory on undergraduate students in the Arab context: A test-retest approach.

PubMed

AlMenhali, Entesar Ali; Khalid, Khalizani; Iyanna, Shilpa

2018-01-01

The Environmental Attitudes Inventory (EAI) was developed to evaluate the multidimensional nature of environmental attitudes; however, it is based on a dataset from outside the Arab context. This study reinvestigated the construct validity of the EAI with a new dataset and confirmed the feasibility of applying it in the Arab context. One hundred and forty-eight subjects in Study 1 and 130 in Study 2 provided valid responses. An exploratory factor analysis (EFA) was used to extract a new factor structure in Study 1, and confirmatory factor analysis (CFA) was performed in Study 2. Both studies generated a seven-factor model, and the model fit was discussed for both the studies. Study 2 exhibited satisfactory model fit indices compared to Study 1. Factor loading values of a few items in Study 1 affected the reliability values and average variance extracted values, which demonstrated low discriminant validity. Based on the results of the EFA and CFA, this study showed sufficient model fit and suggested the feasibility of applying the EAI in the Arab context with a good construct validity and internal consistency.

Testing the psychometric properties of the Environmental Attitudes Inventory on undergraduate students in the Arab context: A test-retest approach

PubMed Central

2018-01-01

The Environmental Attitudes Inventory (EAI) was developed to evaluate the multidimensional nature of environmental attitudes; however, it is based on a dataset from outside the Arab context. This study reinvestigated the construct validity of the EAI with a new dataset and confirmed the feasibility of applying it in the Arab context. One hundred and forty-eight subjects in Study 1 and 130 in Study 2 provided valid responses. An exploratory factor analysis (EFA) was used to extract a new factor structure in Study 1, and confirmatory factor analysis (CFA) was performed in Study 2. Both studies generated a seven-factor model, and the model fit was discussed for both the studies. Study 2 exhibited satisfactory model fit indices compared to Study 1. Factor loading values of a few items in Study 1 affected the reliability values and average variance extracted values, which demonstrated low discriminant validity. Based on the results of the EFA and CFA, this study showed sufficient model fit and suggested the feasibility of applying the EAI in the Arab context with a good construct validity and internal consistency. PMID:29758021

Miocene History of the East Antarctic Ice-sheet Inferred from the Eustatic and Paleoceanographic Record of The Marion Plateau, Northeastern Australia (ODP Leg 194)

NASA Astrophysics Data System (ADS)

John, C. M.; Browning, E.; Lowery, C.; Leckie, R. M.; Karner, G. D.; Schouten, S.

2012-12-01

The East Antarctic Ice Sheet (EAIS) had a major influence on Cenozoic eustasy and paleoceanography. Reconstructing changes in ice volume and climate associated with the EAIS is thus critical to a better understanding of climate dynamics, but this has proven difficult to do using only sedimentary records from Antarctica because ice sheets tend to erase evidences of their own history. It is possible, however, to gain information about the dynamics of the EAIS by reconstructing glacio-eustasy and regional paleoceanographic changes away from Antarctica. We present a record of carbonate deposition spanning the uppermost Oligocene to upper Miocene on the Marion Plateau of Northeastern Australia (ODP Leg 194). The Marion Plateau is ideally located for our study on a tectonically quiescent margin, and it is a sensitive recorder of Antarctic paleoenvironmental changes due to its geographical position in the southern hemisphere. We conducted a multi-disciplinary study involving sedimentology, sequence stratigraphy, calcareous nannofossil and foraminifer micropaleontology, and organic geochemistry. Eleven lower and middle Miocene sequence boundaries can be recognized on the Marion Plateau based on facies and seismic reflection lines, and each sequence boundary (sea-level fall) is associated with a phase of growth of the EAIS (as evidenced by positive shifts in δ18O, termed "Mi Events"). The oldest boundary recovered is 23.16 Ma old. By combining backstripping and δ18O estimates, the amplitude of four of the Miocene eustatic falls are constrained to 27±1 m at 16.5 Ma (Mi2), 27±1 m at 15.6 Ma (Mi2a), 33±3 m at 14.8 Ma (Mi3a), and 59±6 m at 13.6 Ma (Mi3). The amplitude of the eustatic drop associated with event Mi3 suggests a major growth phase of the EAIS in the middle Miocene, which is supported by other deep-sea records and several recent studies from continental Antarctica. Furthermore, nannofossil assemblages show four main clusters corresponding to changes in temperature and productivity on the Marion Plateau; for much of the Miocene, surface waters of the Marion Plateau are characterized by warm, subtropical temperatures, but at 14.8 Ma (coeval with event Mi3a) assemblages suddenly become dominated by the cold-water species Dictyococcites productus and Dictyococcites antarcticus. TEX86 data support the observation based on nannofossil assemblages, suggesting incursions of colder waters on the Marion Plateau from 14.8 Ma to 13.6 Ma, with a progressive return to sub-tropical temperatures afterwards. The combined glacio-eustatic and paleoceanographic records of the Marion Plateau suggest the onset of significant cooling on Antarctica by 14.8 Ma, followed by a major growth phase of the EAIS by 13.6 Ma.

Spoligotyping of Mycobacterium tuberculosis isolates at a tertiary care hospital in India.

PubMed

Suzana, Shirly; Shanmugam, Sivakumar; Uma Devi, K R; Swarna Latha, P N; Michael, Joy S

2017-06-01

Spoligotyping is a valuable genotyping tool to study the genetic diversity and molecular epidemiology of Mycobacterium tuberculosis (M. tb). The aim of this study was to analyse different spoligotype patterns of M. tb strains isolated from patients with tuberculosis from different parts of India. A total of 163 M. tb isolates were spoligotyped between January 2014 and January 2015. About 47% (n = 77) were from patients with extrapulmonary tuberculosis; of these, 10 were MDR, and seven were Pre-XDR. Of the 86 M. tb isolates from patients with pulmonary tuberculosis, 25 were MDR, and 25 were Pre-XDR. We found 61 spoligo patterns, 128 clusters in the spoligotype data base (spoldb4 data base) with spoligo international type (SIT) number and 35 true unique isolates. The most pre-dominant spoligotype was EAI lineage (56), followed by Beijing (28), CAS (20), T(9), U(7), X(3), H(3), BOVIS_1 BCG(1) and LAM(1). Although our study identified EAI, CAS and Beijing strain lineages as pre-dominant, we also found a large number of orphan strains (20%) in our study. Beijing strains were more significantly associated with MDR TB than CAS and EAI lineages. Further studies on large sample sizes would help to clearly describe the epidemiology of M. tb in India. © 2017 John Wiley & Sons Ltd.

Extent of Low-accumulation 'Wind Glaze' Areas on the East Antarctic Plateau: Implications for Continental Ice Mass Balance

NASA Technical Reports Server (NTRS)

Scambos, Theodore A.; Frezzotti, Massimo; Haran, T.; Bohlander, J.; Lenaerts, J. T. M.; Van Den Broeke, M. R.; Jezek, K.; Long, D.; Urbini, S.; Farness, K.;

Preliminary Effect of Synthetic Vision Systems Displays to Reduce Low-Visibility Loss of Control and Controlled Flight Into Terrain Accidents

NASA Technical Reports Server (NTRS)

Glaab, Louis J.; Takallu, Mohammad A.

2002-01-01

An experimental investigation was conducted to study the effectiveness of Synthetic Vision Systems (SVS) flight displays as a means of eliminating Low Visibility Loss of Control (LVLOC) and Controlled Flight Into Terrain (CFIT) accidents by low time general aviation (GA) pilots. A series of basic maneuvers were performed by 18 subject pilots during transition from Visual Meteorological Conditions (VMC) to Instrument Meteorological Conditions (IMC), with continued flight into IMC, employing a fixed-based flight simulator. A total of three display concepts were employed for this evaluation. One display concept, referred to as the Attitude Indicator (AI) replicated instrumentation common in today's General Aviation (GA) aircraft. The second display concept, referred to as the Electronic Attitude Indicator (EAI), featured an enlarged attitude indicator that was more representative of a glass display that also included advanced flight symbology, such as a velocity vector. The third concept, referred to as the SVS display, was identical to the EAI except that computer-generated terrain imagery replaced the conventional blue-sky/brown-ground of the EAI. Pilot performance parameters, pilot control inputs and physiological data were recorded for post-test analysis. Situation awareness (SA) and qualitative pilot comments were obtained through questionnaires and free-form interviews administered immediately after the experimental session. Initial pilot performance data were obtained by instructor pilot observations. Physiological data (skin temperature, heart rate, and muscle flexure) were also recorded. Preliminary results indicate that far less errors were committed when using the EAI and SVS displays than when using conventional instruments. The specific data example examined in this report illustrates the benefit from SVS displays to avoid massive loss of SA conditions. All pilots acknowledged the enhanced situation awareness provided by the SVS display concept. Levels of pilot stress appear to be correlated with skin temperature measurements.

The Last Interglacial History of the Antarctic Ice sheet

NASA Astrophysics Data System (ADS)

Bradley, Sarah; Siddall, Mark; Milne, Glenn A.; Masson-Delmotte, Valerie; Wolff, Eric; Hindmarsh, Richard C. A.

2014-05-01

In this paper we present a summary of the work which was conducted as part of the 'PAST4FUTURE -WP4.1: Sea Level and Ice sheets' project. The overall aim of this study was to understand the response of the Antarctic Ice sheet (AIS) to climate forcing during the Last interglacial (LIG) and its contribution to the observed higher than present sea level during this period. The study involved the application and development of a novel technique which combined East Antarctic stable isotope ice core data with the output from a Glacial Isostatic Adjustment (GIA) model [Bradley et al., 2012]. We investigated if the stable isotope ice core data are sensitive to detecting isostatically driven changes in the surface elevation driven by changes in the ice-loading history of the AIS and if so, could we address some key questions relating to the LIG history of the AIS. Although it is believed that the West Antarctic Ice sheet (WAIS) reduced in size during the LIG compared to the Holocene, major uncertainties and unknowns remain unresolved: Did the WAIS collapse? What would the contribution of such a collapse be the higher than present LIG eustatic sea level (ESL)? We will show that a simulated collapse of the WAIS does not generate a significant elevation driven signal at the EAIS LIG ice core sites, and as such, these ice core records cannot be used to assess WAIS stability over this period. However, we will present 'treasure maps' [Bradley et al., 2012] to identify regions of the AIS where results from geological studies and/or new paleoclimate data may be sensitive to detecting a WAIS collapse. These maps can act as a useful tool for the wider science community/field scientists as a guide to highlight sites suitable to constrain the evolution of the WAIS during the LIG. Studies have proposed that the surface temperature across the East Antarctic Ice Sheet (EAIS) was significantly warmer, 2-5°C during the LIG compared to present [Lang and Wolff, 2011]. These higher temperatures are estimated primarily using the difference in the δD peak in the LIG stable isotope ice core data relative to the records for the present interglacial; a feature which is referred to as the 'LIG overshoot'. Generally studies have attributed most of this signal to changes in the Antarctic climate [Masson-Delmotte et al., 2011]. However, a previously overlooked contribution is the influence of changes in surface elevation driven by changes in ice-loading history of the EAIS [Bradley et al., 2013]. We will show that introducing a relatively moderate reduction in the amount of thickening of the EAIS over the LIG, can generate a significant elevation driven δD signal at the EAIS ice core sites, and as such elevation effects can account for a significant fraction of the LIG overshoot. We will conclude that the potential contribution of this process must be considered when using the EAIS stable isotope ice core data to make estimated of the LIG surface temperature. Finally, we will provide estimates of the contribution of the AIS to both ESL and to the higher than observed relative sea level during the LIG. Bradley, S. L., M. Siddall, G. A. Milne, V. Masson-Delmotte, and E. Wolff (2012), Where might we find evidence of a Last Interglacial West Antarctic Ice Sheet collapse in Antarctic ice core records?, Global and Planetary Change, 88-89(0), 64-75. Bradley, S. L., M. Siddall, G. A. Milne, V. Masson-Delmotte, and E. Wolff (2013), Combining ice core records and ice sheet models to explore the evolution of the East Antarctic Ice sheet during the Last Interglacial period, Global and Planetary Change, 100, 278-290. Lang, N., and E. W. Wolff (2011), Interglacial and glacial variability from the last 800 ka in marine, ice and terrestrial archives, Clim. Past., 7(2), 361-380. Masson-Delmotte, V., et al. (2011), A comparison of the present and last interglacial periods in six Antarctic ice cores, Clim. Past., 7(2), 397-423.

Pliocene East Antarctic Ice Sheet Retreat in the Wilkes Subglacial Basin

NASA Astrophysics Data System (ADS)

Cook, C.; van de Flierdt, T.; Williams, T.; Hemming, S. R.; Pierce, E. L.; Iwai, M.; Kobayashi, M.; Jimenez-Espejo, F.; Escutia, C.; González, J.; Patterson, M. O; Mckay, R. M.; Passchier, S.; Tauxe, L.; Sugisaki, S.; Bohaty, S. M.; Riesselman, C. R.; Sangiorgi, F.; Brinkhuis, H.

2012-12-01

Polar ice sheets are an important component of the climate system, affecting global sea level, ocean circulation and heat transport, marine productivity, and albedo. However, there is considerable uncertainty in the response of the polar ice caps to predicted future warming. Warm intervals during the Pliocene Epoch (5.33-2.58 Ma) may provide insight on the sensitivity of ice sheets when atmospheric carbon dioxide levels were similar to today and temperatures were elevated by a few degrees Celsius. Global sea level during this time has been estimated to lie about 20m above modern, requiring not only Greenland and West Antarctica, but also the large East Antarctic ice sheet (EAIS) to have lost mass. Direct evidence for ice retreat around East Antarctica is, however, sparse. Here we present results of neodymium (Nd) and strontium (Sr) isotope analyses of detrital clay and silt-sized sediments from Integrated Ocean Drilling Program Leg 318 Site U1361 (64°24.57'S, 143°53.19'E), drilled offshore of the Wilkes Subglacial Basin, where large areas of the EAIS lie below sea level. Early Pliocene (5.33 to 3.3 Ma) detrital sediments from this location reveal two distinct endmembers. The first endmember is defined by epsilon Nd values of -11 to -14.5 and Sr isotopic compositions of 0.720 to 0.730, and the second endmember is characterized by more radiogenic values of -5.9 to -9.5 and 0.713 to 0.719, respectively. While the first endmember is consistent with siliciclastic material sourced from Early Paleozoic bedrocks exposed in Oates Land and the western region of Northern Victoria Land to the east of the study site, the second endmember requires a significant contribution (95-70%) from the Jurassic-Triassic Ferrar Large Igneous Province (FLIP), which today is only regionally exposed in volumetrically significant quantities in the Transantarctic Mountains. For this area to be an important source to IODP Site U1361 sediments, significant retreat of outlet glaciers and collapse of the Ross Ice Shelf would be required, as well as transport of detritus over more than 3000km from the Ross Sea by icebergs and/or by bottom currents. While we cannot fully exclude this possibility, we render it unlikely, as provenance analyses on sediments deposited during the early Pleistocene 'super-interglacial' Marine Isotope Stage 31 (1.08 to 1.06 Ma) deposited at IODP Site U1359 show little indication of FLIP signatures. Instead we suggest that FLIP material at IODP Site U1361 is eroded from within the Wilkes Subglacial Basin during times of retreat of the EAIS. This interpretation is supported by aerogeophysical surveys implying that FLIP intrusions and sedimentary infill are present within the Wilkes Subglacial Basin. Times of predominance of a FLIP signature in IODP Site U1361 detrital sediments correlates with Pliocene episodes of pronounced warmth in the Southern Ocean, identified by changes in sedimentology, physical properties, bulk geochemistry and micropaleontology. In summary, our results indicate that the Wilkes Subglacial Basin was a key location of EAIS destabilisation during warm intervals of the Pliocene, with implications for both Pliocene and future climate change.

Functionalization of reduced graphene oxide by electroactive polymer for biosensing applications

NASA Astrophysics Data System (ADS)

Nguyen, Le Huy; Dzung Nguyen, Tuan; Hoang Tran, Vinh; Thu Huyen Dang, Thi; Tran, Dai Lam

2014-09-01

A novel biosensing platform was designed by the functionalizing reduced graphene oxide sheets (rGO) with electroactive copolymer juglone. The composite film showed well-defined, stable electroactivity in a biocompatible buffer medium. Square wave voltammetry is used to record the redox signal for DNA hybridization. Current increase upon hybridization (signal-on) evidenced that short DNA target as well as polymerase chain reaction (PCR), so called ‘real sample’ products, related to different lineages of Mycobacterium tuberculosis strain. The signal-on reached ∼40% with 1 nM of short DNA (25 mer) target, while PCR product (Africanum, EAI and Beijing strains) produced a current change of ∼20%.

Records of past ice sheet fluctuations in interior East Antarctica

USGS Publications Warehouse

Liu, Xiaohan; Huang, Feixin; Kong, Ping; Fang, Aimin; Li, Xiaoli

2007-01-01

The results of a land-based multi-disciplinary study of the past ice surface elevation in the Grove Mountains of interior East Antarctica support a dynamic evolution of the East Antarctic Ice Sheet (EAIS). Moraine boulders of sedimentary rocks and spore pollen assemblage imply a significant shrinkage of the EAIS, with its margin retreating south of the Grove Mountains (~450 km south of recent coast line) before the middle Pliocene. The exposure ages indicate that the ice sheet subsequently re-advanced, with the ice surface rising locally at least 450 m higher than today. It then went back down constantly from before 2.3 Ma to 1.6 Ma. The glacial topography and existence of soil show that the ice surface fluctuation continued since the early Quaternary, but with highest levels never exceeding ~100 m higher than today.

Adiposity, body composition and ventricular-arterial stiffness in the elderly: the Atherosclerosis Risk in Communities Study.

PubMed

Fernandes-Silva, Miguel M; Shah, Amil M; Claggett, Brian; Cheng, Susan; Tanaka, Hirofumi; Silvestre, Odilson M; Nadruz, Wilson; Borlaug, Barry A; Solomon, Scott D

2018-04-16

Weight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community. Adiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage. We studied the association of these measures with carotid-femoral pulse wave velocity (cfPWV), arterial elastance index (EaI), left ventricular (LV) end-systolic elastance index (EesI) and LV end-diastolic elastance index (EedI) in 5520 community-based, elderly Atherosclerosis Risk in Communities (ARIC) Study participants, who underwent echocardiography between 2011 and 2013. BMI and waist circumference were directly associated with EaI, EedI and EesI even after adjusting for age, sex, race, hypertension, diabetes mellitus, heart rate, prevalent coronary heart disease and HF. After further adjustment for BMI, body fat percentage demonstrated significant independent linear relationships with EaI [standardized beta coefficient (β)=0.17, P<0.001], EesI (β=0.08, P=0.003) and EedI (β=0.20, P<0.001), and significant non-linear relationships with cfPWV (P=0.033). In this biracial community-based cohort, increased adiposity was associated with increased ventricular-arterial stiffness among the elderly and suggests a potential mechanism by which obesity might contribute to the development of HF. © 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology.

Rapid Swings between Greenhouse and Icehouse Climate States near the Oligocene - Miocene Boundary

NASA Astrophysics Data System (ADS)

Zhang, Y.; Fraass, A.; Ruan, J.; Jin, X.; D'haenens, S.; Gasson, E.; Deconto, R. M.; Pearson, A.; Leckie, R. M.; Liu, C.; Liebrand, D.; Hull, P. M.; Pagani, M.

2017-12-01

The Earth's Cenozoic climate is conventionally portrayed as either being in a greenhouse or an icehouse conditions. Greenhouse climates are characterized by warm temperatures, high CO2 concentrations, low continental ice volume and reduced meridional temperature gradients, whereas icehouse climates are the opposite. The transition between greenhouse and icehouse primarily is achieved through stepwise and unidirectional cooling, ice sheet growth and increases in the meridional temperature gradients. Various feedbacks in the climate system and the global carbon cycle as well as the ice sheet hysteresis effect seem to preclude substantial fluctuations in the meridional temperature gradients, atmospheric CO2 concentrations and the volume of the East Antarctic Ice Sheet (EAIS) on a high frequency (orbital timescales). For example, relative to the Holocene, the last glacial maximum (LGM) is characterized by relatively small pCO2 changes (80-100 parts per million, ppm), similar cooling between the mid- and low-latitudes, and a stable East Antarctica Ice Sheet (EAIS). However, here we present geochemical reconstructions that appear to indicate large and rapid swings of CO2 (>200 ppm) and meridional temperature gradients near the Oligocene - Miocene (O-M) boundary ( 23 Ma). Further, transient waxing and waning of the EAIS during the Mi-1 glaciation is suggested by ice volume calculations based on benthic δ18O data, which are supported by the glaciomarine sequences deposited at the Ross Sea. Our results demonstrate a high sensitivity of surface ocean temperatures and temperature gradients, the global carbon cycle, and the cryosphere to changes in boundary conditions, with implications for our future.

Predictors of health-related quality of life of European food-allergic patients.

PubMed

Saleh-Langenberg, J; Goossens, N J; Flokstra-de Blok, B M J; Kollen, B J; van der Meulen, G N; Le, T M; Knulst, A C; Jedrzejczak-Czechowicz, M; Kowalski, M L; Rokicka, E; Starosta, P; de la Hoz Caballer, B; Vazquez-Cortés, S; Cerecedo, I; Barreales, L; Asero, R; Clausen, M; DunnGalvin, A; Hourihane, J O' B; Purohit, A; Papadopoulos, N G; Fernandéz-Rivas, M; Frewer, L; Burney, P; Duiverman, E J; Dubois, A E J

2015-06-01

Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food-allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food-allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. A total of 648 European food-allergic patients (404 adults, 244 children) completed an age-specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto-injector (EAI) contributed to impairment of HRQL. In this study, food allergy-related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Design validation and labeling comprehension study for a new epinephrine autoinjector.

PubMed

Edwards, Eric S; Edwards, Evan T; Gunn, Ronald; Patterson, Patricia; North, Robert

2013-03-01

To facilitate the correct use of epinephrine autoinjectors (EAIs) by patients and caregivers, a novel EAI (Auvi-Q) was designed to help minimize use-related hazards. To support validation of Auvi-Q final design and assess whether the instructions for use in the patient information leaflet (PIL) are effective in training participants on proper use of Auvi-Q. Healthy participants, 20 adult and 20 pediatric, were assessed for their ability to complete a simulated injection by following the Auvi-Q instructions for use. Participants relied only on the contents of the PIL and other labeling features (device labeling and its instructions for use, electronic voice instructions and visual prompts). The mean ± SD age of the adult and pediatric participants was 39.4 ± 11.6 and 10.9 ± 2.3 years, respectively. In total, 80% of adult and 35% of pediatric participants had prior experience with EAIs. All adults and 95% of pediatric participants completed a simulated injection on the first attempt; 1 pediatric participant required parental training and a second attempt. Three adult and 4 pediatric participants exhibited a noncritical issue while successfully completing the simulated injection. Most participants agreed that the injection steps were easy to follow and the PIL facilitated understanding on using Auvi-Q safely and effectively. The PIL and other labeling features were effective in communicating instructions for successful use of Auvi-Q. This study provided validation support for the final design and anticipated instructions for use of Auvi-Q. Copyright © 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Sea-level Change during Hothouse, Cool Greenhouse, and Icehouse Worlds

NASA Astrophysics Data System (ADS)

Miller, K. G.; Browning, J. V.; Wright, J. D.

2015-12-01

Comparison of sea level and climate proxies shows fundamentally different causes and responses (periods, amplitudes, rates) for Myr scale sea-level changes in Hothouse, Cool Greenhouse, and Icehouse worlds. Peak warmth of the past 100 million years was achieved in the Hothouse intervals of the Cenomanian-Santonian (ca. 100-80 Ma) and early Eocene (56-50 Ma). Hothouse global average sea level falls of ~15 m are associated with d18O increases that reflect primarily high latitude cooling and may reflect the growth of small ice sheets in elevated regions of Antarctica. However, these purported Hothouse ice sheets are at or below the detection level of the d18O proxy (15 m ≤ 0.15‰), and it is possible that changes in groundwater storage ('limnoeustasy') could have caused these falls. Cool greenhouse (Campanian to Paleocene, middle to late Eocene) sea-level changes of 15-25 m were caused by growth and decay of small (25-35% of modern) ice sheets, pacing sea-level change on an apparent 2.4 Myr long eccentricity cycle, likely modulating 405 and 100 kyr cycles. Icehouse (past 33.8 Myr) sea-level and ice-volume changes were paced by the 1.2 Myr tilt cycle, with alternating states of 41 and 100 kyr dominance. Warm periods in the Icehouse displayed different sea-level responses. During the largely unipolar Icehouse of the Oligocene to early Miocene, the East Antarctic Ice Sheet (EAIS) was not permanently developed, with intervals of large-scale (~40-55 m sea level equivalent) growth and collapse. During peak warmth of the Miocene Climate Optimum (MCO; ~17-15 Ma) ice volume changes were small (generally <20 m) and paced by the 100 kyr cycle. A permanent EAIS developed following 3 middle Miocene d18O increases (14.7, 13.8, and 13.2 Ma) that were largely cooling events associated with <40 m sea-level falls; the subsequent late Miocene EAIS displayed lower amplitude (~20-30 m) sea-level variations. Despite only moderate atmospheric CO2 levels (400±50 ppm), during the peak warmth interval of the Pliocene, sea levels were only 22±10 m above present (most likely 12-22 m) requiring loss of Greenland, West Antarctica, and small part of EAIS (likely the Wilkes Basin).

Analysing aeromagnetic, airborne gravity and radar data to unveil variable basal boundary conditions for the East Antarctic Ice Sheet in the Wilkes Subglacial Basin

NASA Astrophysics Data System (ADS)

Armadillo, Egidio; Ferraccioli, Fausto; Young, Duncan; Balbi, Pietro; Blankenship, Don; Jordan, Tom; Bozzo, Emanuele; Siegert, Martin

2014-05-01

The Wilkes Subglacial Basin (WSB) extends for ca 1,400 km from George V Land into the interior of East Antarctica and hosts several major glaciers that drain a large sector of the East Antarctic Ice Sheet (EAIS). The region is of major significance for assessing the long-term stability of the EAIS, as it lies well below sea level and its bedrock deepens inland. This makes it potentially more prone to marine ice sheet instability, much like areas of the West Antarctic Ice Sheet (WAIS) that are presently experiencing significant mass loss. This sector of the EAIS has also become a focus of current research within IODP Leg 318 that aims to better comprehend the initial stages of glaciation and the history and stability of the EAIS since the Eocene-Oligocene boundary. Understanding geological boundary conditions onshore is important to assess their influence on ice sheet dynamics and long-term stability and interpret the paleo-ice sheet record. Early geophysical models inferred the existence of a major extensional sedimentary basin beneath the WSB. This could in principle be similar to some areas of the WAIS, where subglacial sediments deposited within rift basins or forming thin marine sedimentary drapes have been inferred to exert a key influence on both the onset and maintenance of fast-glacial flow. However, later geophysical models indicated that the WSB contains little or no sediment, is not rift-related, and formed in response to Cenozoic flexural uplift of the Transantarctic Mountains (TAM). A major joint Italian-UK aerogeophysical exploration campaign over parts of the WSB is super-seeding all these earlier geophysical views of the basin (Ferraccioli et al., 2009, Tectonophysics). Precambrian and Paleozoic basement faults can now be recognised as exerting fundamental controls on the location of both the topographic margins of the basin and it sub-basins; ii) the crust underlying the basin is thinner compared to the TAM (Jordan et al., 2013, Tectonophysics), but is unlikely to be strongly affected by Cretaceous or Cenozoic-age rifting, in contrast to the WAIS, which is largely underlain by the West Antarctic Rift System; iii) its bedrock is composed of rocks of different ages and composition, including Proterozoic basement, Neoproterozoic and Cambrian sediments intruded by Cambrian arc rocks, and cover rocks formed primarily by Beacon sediments intruded by Jurassic Ferrar sills (e.g. Cook et al., 2013 Nature Geoscience). Within the framework of the collaborative Italian-US-UK BABOC project a new international initiative has been launched to analyse and model variable geological boundary conditions in the WSB using geophysical data. A large amount of new ICECAP aerogeophysical observations have been acquired over four campaigns over the region since the International Polar Year, in particular over the southern part of the basin, and some profiles over the northern coastal margin of the basin. We will present an initial interpretation of the potential field signatures and radar data over the northern and central parts of the basin to help establish tectonic and lithological controls on the subglacial topography and different EAIS flow regimes within the WSB.

Genotyping and drug resistance patterns of M. tuberculosis strains in Pakistan.

PubMed

Tanveer, Mahnaz; Hasan, Zahra; Siddiqui, Amna R; Ali, Asho; Kanji, Akbar; Ghebremicheal, Solomon; Hasan, Rumina

2008-12-24

The incidence of tuberculosis in Pakistan is 181/100,000 population. However, information about transmission and geographical prevalence of Mycobacterium tuberculosis strains and their evolutionary genetics as well as drug resistance remains limited. Our objective was to determine the clonal composition, evolutionary genetics and drug resistance of M. tuberculosis isolates from different regions of the country. M. tuberculosis strains isolated (2003-2005) from specimens submitted to the laboratory through collection units nationwide were included. Drug susceptibility was performed and strains were spoligotyped. Of 926 M. tuberculosis strains studied, 721(78%) were grouped into 59 "shared types", while 205 (22%) were identified as "Orphan" spoligotypes. Amongst the predominant genotypes 61% were Central Asian strains (CAS ; including CAS1, CAS sub-families and Orphan Pak clusters), 4% East African-Indian (EAI), 3% Beijing, 2% poorly defined TB strains (T), 2% Haarlem and LAM (0.2). Also TbD1 analysis (M. tuberculosis specific deletion 1) confirmed that CAS1 was of "modern" origin while EAI isolates belonged to "ancestral" strain types.Prevalence of CAS1 clade was significantly higher in Punjab (P < 0.01, Pearsons Chi-square test) as compared with Sindh, North West Frontier Province and Balochistan provinces. Forty six percent of isolates were sensitive to five first line antibiotics tested, 45% were Rifampicin resistant, 50% isoniazid resistant. MDR was significantly associated with Beijing strains (P = 0.01, Pearsons Chi-square test) and EAI (P = 0.001, Pearsons Chi-square test), but not with CAS family. Our results show variation of prevalent M. tuberculosis strain with greater association of CAS1 with the Punjab province. The fact that the prevalent CAS genotype was not associated with drug resistance is encouraging. It further suggests a more effective treatment and control programme should be successful in reducing the tuberculosis burden in Pakistan.

Error affect inoculation for a complex decision-making task.

PubMed

Tabernero, Carmen; Wood, Robert E

2009-05-01

Individuals bring knowledge, implicit theories, and goal orientations to group meetings. Group decisions arise out of the exchange of these orientations. This research explores how a trainee's exploratory and deliberate process (an incremental theory and learning goal orientation) impacts the effectiveness of individual and group decision-making processes. The effectiveness of this training program is compared with another program that included error affect inoculation (EAI). Subjects were 40 Spanish Policemen in a training course. They were distributed in two training conditions for an individual and group decision-making task. In one condition, individuals received the Self-Guided Exploration plus Deliberation Process instructions, which emphasised exploring the options and testing hypotheses. In the other condition, individuals also received instructions based on Error Affect Inoculation (EAI), which emphasised positive affective reactions to errors and mistakes when making decisions. Results show that the quality of decisions increases when the groups share their reasoning. The AIE intervention promotes sharing information, flexible initial viewpoints, and improving the quality of group decisions. Implications and future directions are discussed.

Temperature and Snowfall in Western Queen Maud Land Increasing Faster Than Climate Model Projections

NASA Astrophysics Data System (ADS)

Medley, B.; McConnell, J. R.; Neumann, T. A.; Reijmer, C. H.; Chellman, N.; Sigl, M.; Kipfstuhl, S.

2018-02-01

East Antarctic Ice Sheet (EAIS) mass balance is largely driven by snowfall. Recently, increased snowfall in Queen Maud Land led to years of EAIS mass gain. It is difficult to determine whether these years of enhanced snowfall are anomalous or part of a longer-term trend, reducing our ability to assess the mitigating impact of snowfall on sea level rise. We determine that the recent snowfall increases in western Queen Maud Land (QML) are part of a long-term trend (+5.2 ± 3.7% decade-1) and are unprecedented over the past two millennia. Warming between 1998 and 2016 is significant and rapid (+1.1 ± 0.7°C decade-1). Using these observations, we determine that the current accumulation and temperature increases in QML from an ensemble of global climate simulations are too low, which suggests that projections of the QML contribution to sea level rise are potentially overestimated with a reduced mitigating impact of enhanced snowfall in a warming world.

Temperature and Snowfall in Western Queen Maud Land Increasing Faster than Climate Model Projections

NASA Technical Reports Server (NTRS)

Medley, B.; McConnell, J. R.; Neumann, T. A.; Reijmer, C. H.; Chellman, N.; Sigl, M.; Kipfstuhl, S.

2017-01-01

East Antarctic Ice Sheet (EAIS) mass balance is largely driven by snowfall. Recently, increased snowfall in Queen Maud Land led to years of EAIS mass gain. It is difficult to determine whether these years of enhanced snowfall are anomalous or part of a longer-term trend, reducing our ability to assess the mitigating impact of snowfall on sea level rise. We determine that the recent snowfall increases in western Queen Maud Land (QML) are part of a long-term trend (+5.2 +/- 3.7% decade(exp -1)) and are unprecedented over the past two millennia. Warming between 1998 and 2016 is significant and rapid (+1.1 +/- 0.7 C decade(exp -1)). Using these observations, we determine that the current accumulation and temperature increases in QML from an ensemble of global climate simulations are too low, which suggests that projections of the QML contribution to sea level rise are potentially overestimated with a reduced mitigating impact of enhanced snowfall in a warming world.

Preservice Science Teachers' Attitudes toward Environment

ERIC Educational Resources Information Center

Koc, Isil; Kuvac, Meltem

2016-01-01

The purpose of this study was to determine preservice science teachers' attitudes toward environment and to investigate whether their environmental attitudes differ in terms of gender and grade level. A total of 197 preservice science teachers participated in the study. Personal Information Form and the Environmental Attitudes Inventory (EAI)…

A Hybrid Computer Simulation to Generate the DNA Distribution of a Cell Population.

ERIC Educational Resources Information Center

Griebling, John L.; Adams, William S.

1981-01-01

Described is a method of simulating the formation of a DNA distribution, on which statistical results and experimentally measured parameters from DNA distribution and percent-labeled mitosis studies are combined. An EAI-680 and DECSystem-10 Hybrid Computer configuration are used. (Author/CS)

Comparisons of Mathematics Intervention Effects in Resource and Inclusive Classrooms

ERIC Educational Resources Information Center

Bottge, Brian A.; Cohen, Allan S.; Choi, Hye-Jeong

2018-01-01

In this article, we describe results of a reanalysis of two randomized studies that tested the effects of enhanced anchored instruction (EAI) on the fractions computation performance of students in special education resource rooms and inclusive mathematics classrooms. Latent class analysis and latent transition analysis classified students…

77 FR 48511 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... effective 9/1/2012. Filed Date: 8/6/12. Accession Number: 20120806-5135. Comments Due: 5 p.m. ET 8/27/12...: EAI Marketing Agreement Refile to be effective 10/1/ 2012. Filed Date: 8/6/12. Accession Number...

Parent Perceptions of Psychosocial Outcomes of Equine-Assisted Interventions for Children with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Tan, Vanessa Xue-Ling; Simmonds, Janette Graetz

2018-01-01

This research explored parents' perceptions of the psychosocial outcomes of their children's experience of receiving equine-assisted interventions (EAI). Participants were the parents of six children (aged 3-14) diagnosed with autism spectrum disorder. Five semi-structured interviews were conducted and the transcript data was analysed using…

The Private Management of Public Schools: The Hartford, Connecticut, Experience.

ERIC Educational Resources Information Center

Cazares, Patricia

During the early 1990s, the Hartford, Connecticut, public school system experienced serious financial problems and a downward trend in the key indicators of educational success. In 1994 the Hartford, Connecticut, board of education granted Education Alternatives, Incorporated (EAI), a 5-year contract to manage the school district. This paper…

Measurement of plasma decay processes in mixture of sodium and argon by coherent microwave scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang Zhili; Shneider, Mikhail N.

2010-03-15

This paper presents the experimental measurement and computational model of sodium plasma decay processes in mixture of sodium and argon by using radar resonance-enhanced multiphoton ionization (REMPI), coherent microwave Rayleigh scattering of REMPI. A single laser beam resonantly ionizes the sodium atoms by means of 2+1 REMPI process. The laser beam can only generate the ionization of the sodium atoms and have negligible ionization of argon. Coherent microwave scattering in situ measures the total electron number in the laser-induced plasma. Since the sodium ions decay by recombination with electrons, microwave scattering directly measures the plasma decay processes of the sodiummore » ions. A theoretical plasma dynamic model, including REMPI of the sodium and electron avalanche ionization (EAI) of sodium and argon in the gas mixture, has been developed. It confirms that the EAI of argon is several orders of magnitude lower than the REMPI of sodium. The theoretical prediction made for the plasma decay process of sodium plasma in the mixture matches the experimental measurement.« less

Genetic biodiversity of Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in India.

PubMed

Singh, Urvashi Balbir; Arora, Jyoti; Suresh, Naga; Pant, Hema; Rana, Tanu; Sola, Christophe; Rastogi, Nalin; Pande, Jitendra Nath

2007-07-01

Spoligotyping was performed on 540 Mycobacterium tuberculosis isolates in order to evaluate the genetic biodiversity of tubercle bacilli in India. One hundred and forty seven patterns were unique and 393 were grouped in 48 clusters. Comparison with an international spoligotype database showed that the most predominant clades among tuberculosis (TB) isolates were Central Asian (CAS) and East-African Indian (EAI) with shared-types (ST) ST26 and ST11 alone being responsible for 34% of all TB cases. Twenty one (3.8%) isolates belonged to the Beijing genotype. Marked variations were observed among circulating strains, STs belonging to CAS family predominated in the North, whereas the EAI family was more common in the Southern India. TB in India is predominantly caused by strains belonging to the principal genetic group 1 (PGG1), suggesting that most of the TB burden in India may be traced to ancestral clones of the tubercle bacilli. This study gives an insight into the global M. tuberculosis genetic biodiversity in India, the predominant spoligotypes and their impact on disease transmission.

Genotyping and drug resistance patterns of M. tuberculosis strains in Pakistan

PubMed Central

Tanveer, Mahnaz; Hasan, Zahra; Siddiqui, Amna R; Ali, Asho; Kanji, Akbar; Ghebremicheal, Solomon; Hasan, Rumina

2008-01-01

Background The incidence of tuberculosis in Pakistan is 181/100,000 population. However, information about transmission and geographical prevalence of Mycobacterium tuberculosis strains and their evolutionary genetics as well as drug resistance remains limited. Our objective was to determine the clonal composition, evolutionary genetics and drug resistance of M. tuberculosis isolates from different regions of the country. Methods M. tuberculosis strains isolated (2003–2005) from specimens submitted to the laboratory through collection units nationwide were included. Drug susceptibility was performed and strains were spoligotyped. Results Of 926 M. tuberculosis strains studied, 721(78%) were grouped into 59 "shared types", while 205 (22%) were identified as "Orphan" spoligotypes. Amongst the predominant genotypes 61% were Central Asian strains (CAS ; including CAS1, CAS sub-families and Orphan Pak clusters), 4% East African-Indian (EAI), 3% Beijing, 2% poorly defined TB strains (T), 2% Haarlem and LAM (0.2). Also TbD1 analysis (M. tuberculosis specific deletion 1) confirmed that CAS1 was of "modern" origin while EAI isolates belonged to "ancestral" strain types. Prevalence of CAS1 clade was significantly higher in Punjab (P < 0.01, Pearsons Chi-square test) as compared with Sindh, North West Frontier Province and Balochistan provinces. Forty six percent of isolates were sensitive to five first line antibiotics tested, 45% were Rifampicin resistant, 50% isoniazid resistant. MDR was significantly associated with Beijing strains (P = 0.01, Pearsons Chi-square test) and EAI (P = 0.001, Pearsons Chi-square test), but not with CAS family. Conclusion Our results show variation of prevalent M. tuberculosis strain with greater association of CAS1 with the Punjab province. The fact that the prevalent CAS genotype was not associated with drug resistance is encouraging. It further suggests a more effective treatment and control programme should be successful in reducing the tuberculosis burden in Pakistan. PMID:19108722

Epinephrine in Anaphylaxis: Preclinical Study of Pharmacokinetics after Sublingual Administration of Taste-Masked Tablets for Potential Pediatric Use

PubMed Central

Rawas-Qalaji, Mutasem; Simons, Keith J.

2018-01-01

Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to fatalities—especially in children. A novel rapidly-disintegrating sublingual tablet (RDST) of epinephrine was developed in our laboratory as a potential alternative dosage form. The aim of this study was to evaluate the sublingual bioavailability of epinephrine 30 mg as a potential pediatric dose incorporated in our novel taste-masked RDST in comparison with intramuscular (IM) epinephrine 0.15 mg from EAI, the recommended and only available dosage form for children in community settings. We studied the rate and extent of epinephrine absorption in our validated rabbit model (n = 5) using a cross-over design. The positive control was IM epinephrine 0.15 mg from an EpiPen Jr®. The negative control was a placebo RDST. Tablets were placed under the tongue for 2 min. Blood samples were collected at frequent intervals and epinephrine concentrations were measured using HPLC with electrochemical detection. The mean ± SEM maximum plasma concentration (Cmax) of 16.7 ± 1.9 ng/mL at peak time (Tmax) of 21 min after sublingual epinephrine 30 mg did not differ significantly (p > 0.05) from the Cmax of 18.8 ± 1.9 ng/mL at a Tmax of 36 min after IM epinephrine 0.15 mg. The Cmax of both doses was significantly higher than the Cmax of 7.5 ± 1.7 ng/mL of endogenous epinephrine after placebo. These taste-masked RDSTs containing a 30 mg dose of epinephrine have the potential to be used as an easy-to-carry, palatable, non-invasive treatment for anaphylactic episodes for children in community settings. PMID:29439456

Geological Influences on Bedrock Topography and East Antarctic Ice Sheet Dynamics in the Wilkes Subglacial Basin

NASA Astrophysics Data System (ADS)

Ferraccioli, F.; Armadillo, E.; Young, D. A.; Blankenship, D. D.; Jordan, T. A.; Balbi, P.; Bozzo, E.; Siegert, M. J.

2014-12-01

The Wilkes Subglacial Basin (WSB) extends for 1,400 km from George V Land into the interior of East Antarctica and hosts several major glaciers that drain a large sector of the East Antarctic Ice Sheet (EAIS). This region is of key significance for the long-term stability of the ice sheet in East Antarctica, as it lies well below sea level and its bedrock deepens inland, making it potentially prone to marine ice sheet instability, much like areas of the West Antarctic Ice Sheet (WAIS) that are presently experiencing significant mass loss. We present new enhanced potential field images of the WSB combined with existing radar imaging to study geological controls on bedrock topography and ice flow regimes in this key sector of the ice sheet. These images reveal mayor Precambrian and Paleozoic basement faults that exert tectonic controls both on the margins of the basin and its sub-basins. Several major sub-basins can be recognised: the Eastern Basin, the Central Basins and the Western Basins. Using ICECAP aerogeophysical data we show that these tectonically controlled interior basins connect to newly identified basins underlying the Cook Ice Shelf region. This connection implies that any ocean-induced changes at the margin of the EAIS could potentially propagate rapidly further into the interior. With the aid of simple magnetic and gravity models we show that the WSB does not presently include major post Jurassic sedimentary infill. Its bedrock geology is highly variable and includes Proterozoic basement, Neoproterozoic and Cambrian sediments, intruded by Cambrian arc rocks, and cover rocks formed by Beacon sediments intruded by Jurassic Ferrar sills. Enhanced ice flow in this part of the EAIS occurs therefore in a area of mixed and spatially variable bedrock geology. This contrasts with some regions of the WAIS where more extensive sedimentary basins may represent a geological template for the onset and maintenance of fast glacial flow.

Can we apply the 10Be/9Be flux tracer to marine sediments along glaciated margins?

NASA Astrophysics Data System (ADS)

Valletta, R. D.; Willenbring, J. K.; Passchier, S.; Elmi, C.

2016-12-01

Radioactive cosmogenic 10Be normalized to its stable isotope 9Be is proposed as a tracer of continental deposition into the marine basins throughout the Late Cenozoic. Close to glaciated margins, 10Be/9Be may reflect shifts in ice sheet dynamics whereby ice sheet retraction is accompanied by increases in freshwater discharge and terrestrial weathering, which may both increase 10Be and 9Be delivery to the continental shelf. However, this signal is complicated by boundary scavenging during periods of warmth and increased productivity. To disentangle the environmental and biological imprint on the 10Be/9Be isotope record, we sampled extensively characterized marine sedimentary packages offshore the Wilkes Subglacial Basin in an area where East Antarctic Ice Sheet (EAIS) retraction and advance is well-established (IODP U1361A). Combining this existing data with our new measurements creates a uniquely large, multi-proxy dataset for geochemical reconstructions along a glaciated margin. We measured 10Be, 9Be and a suite of bio-reactive transition metals from alternating diatom-rich and diatom-poor clay units 1) adsorbed to authigenic clays and 2) contained within diatom frustules, making this the first dataset of its kind. Diatom-rich clay sediments mark abrupt periods of Pliocene warming and a retracted EAIS. Beryllium co-varies with diatom-rich units: maximum 10Be ( 1.3 x 109 atoms g-1) and 9Be ( 300 ng g-1) peak during warmer intervals. These data mimic patterns observed in the nearby Ross Sea (Yokoyama et al., 2016), suggesting that interglacials are marked along glaciated margins by sudden pulses in Be delivery. By accounting for the Be inventory within diatoms, we have allowed for the exciting pairing of 10Be with 26Al to obtain 1) particle flux and 2) freshwater volume discharged from the EAIS during melting events. These values may offer an approach to constraining changes in two elusive parameters: subglacial erosion and ice sheet melt.

Estimating Antarctic Geothermal Heat Flux using Gravity Inversion

NASA Astrophysics Data System (ADS)

Vaughan, Alan P. M.; Kusznir, Nick J.; Ferraccioli, Fausto; Leat, Phil T.; Jordan, Tom A. R. M.; Purucker, Michael E.; Golynsky, A. V.; Sasha Rogozhina, Irina

2013-04-01

Geothermal heat flux (GHF) in Antarctica is very poorly known. We have determined (Vaughan et al. 2012) top basement heat-flow for Antarctica and adjacent rifted continental margins using gravity inversion mapping of crustal thickness and continental lithosphere thinning (Chappell & Kusznir 2008). Continental lithosphere thinning and post-breakup residual thicknesses of continental crust determined from gravity inversion have been used to predict the preservation of continental crustal radiogenic heat productivity and the transient lithosphere heat-flow contribution within thermally equilibrating rifted continental and oceanic lithosphere. The sensitivity of present-day Antarctic top basement heat-flow to initial continental radiogenic heat productivity, continental rift and margin breakup age has been examined. Knowing GHF distribution for East Antarctica and the Gamburtsev Subglacial Mountains (GSM) region in particular is critical because: 1) The GSM likely acted as key nucleation point for the East Antarctic Ice Sheet (EAIS); 2) the region may contain the oldest ice of the EAIS - a prime target for future ice core drilling; 3) GHF is important to understand proposed ice accretion at the base of the EAIS in the GSM and its links to sub-ice hydrology (Bell et al. 2011). An integrated multi-dataset-based GHF model for East Antarctica is planned that will resolve the wide range of estimates previously published using single datasets. The new map and existing GHF distribution estimates available for Antarctica will be evaluated using direct ice temperature measurements obtained from deep ice cores, estimates of GHF derived from subglacial lakes, and a thermodynamic ice-sheet model of the Antarctic Ice Sheet driven by past climate reconstructions and each of analysed heat flow maps, as has recently been done for the Greenland region (Rogozhina et al. 2012). References Bell, R.E., Ferraccioli, F., Creyts, T.T., Braaten, D., Corr, H., Das, I., Damaske, D., Frearson, N., Jordan, T., Rose, K., Studinger, M. & Wolovick, M. 2011. Widespread persistent thickening of the East Antarctic Ice Sheet by freezing from the base. Science, 331 (6024), 1592-1595. Chappell, A.R. & Kusznir, N.J. 2008. Three-dimensional gravity inversion for Moho depth at rifted continental margins incorporating a lithosphere thermal gravity anomaly correction. Geophysical Journal International, 174 (1), 1-13. Golynsky, A.V. & Golynsky, D.A. 2009. Rifts in the tectonic structure of East Antarctica (in Russian). Russian Earth Science Research in Antarctica, 2, 132-162. Rogozhina, I., Hagedoorn, J.M., Martinec, Z., Fleming, K., Soucek, O., Greve, R. & Thomas, M. 2012. Effects of uncertainties in the geothermal heat flux distribution on the Greenland Ice Sheet: An assessment of existing heat flow models. Journal of Geophysical Research-Earth Surface, 117 (F2), F02025. Vaughan, A.P.M., Kusznir, N.J., Ferraccioli, F. & Jordan, T.A.R.M. 2012. Regional heat-flow prediction for Antarctica using gravity inversion mapping of crustal thickness and lithosphere thinning. Geophysical Research Abstracts, 14, EGU2012-8095.

Teaching Mathematical Problem Solving to Middle School Students in Math, Technology Education, and Special Education Classrooms

ERIC Educational Resources Information Center

Bottge, Brian A.; Heinrichs, Mary; Mehta, Zara Dee; Rueda, Enrique; Hung, Ya-Hui; Danneker, Jeanne

2004-01-01

This study compared two approaches for teaching sixth-grade middle school students to solve math problems in math, technology education, and special education classrooms. A total of 17 students with disabilities and 76 students without disabilities were taught using either enhanced anchored instruction (EAI) or text-based instruction coupled with…

Optimizing the Environmental Attitudes Inventory: Establishing a Baseline of Change in Students' Attitudes

ERIC Educational Resources Information Center

Sutton, Stephen G.; Gyuris, Emma

2015-01-01

Purpose: The purpose of this study was twofold: first, to optimize the Environmental Attitudes Inventory (EAI) and second, to establish a baseline of the difference in environmental attitudes between first and final year students, taken at the start of a university's declaration of commitment to EfS. Design/methodology/approach: The…

Impact of Enhanced Anchored Instruction in Inclusive Math Classrooms

ERIC Educational Resources Information Center

Bottge, Brian A.; Toland, Michael D.; Gassaway, Linda; Butler, Mark; Choo, Sam; Griffen, Ann Katherine; Ma, Xin

2015-01-01

The Common Core State Standards for Mathematics will place more pressure on special education and math teachers to raise the skill levels of all students, especially those with disabilities in math (MD). The purpose of this study was to assess the effects of enhanced anchored instruction (EAI) on students with and without MD in co-taught general…

NLM Emergency Access Initiative: FAQs

Science.gov Websites

provide temporary free access to full-text articles from over 650 biomedical serial titles and over 4,000 specified on the EAI welcome page can access the free full text resources during the period indicated to will I have access to this site? The dates of the free access period are listed on the home page along

76 FR 65975 - Fisheries of the Exclusive Economic Zone Off Alaska; Atka Mackerel in the Bering Sea and Aleutian...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-25

.... 101126521-0640-02] RIN 0648-XA783 Fisheries of the Exclusive Economic Zone Off Alaska; Atka Mackerel in the Bering Sea and Aleutian Islands Management Area AGENCY: National Marine Fisheries Service (NMFS... district (BS/EAI) of the Bering Sea and Aleutian Island management area (BSAI) by vessels participating in...

Profile and Functional Properties of Seed Proteins from Six Pea (Pisum sativum) Genotypes

PubMed Central

Barac, Miroljub; Cabrilo, Slavica; Pesic, Mirjana; Stanojevic, Sladjana; Zilic, Sladjana; Macej, Ognjen; Ristic, Nikola

2010-01-01

Extractability, extractable protein compositions, technological-functional properties of pea (Pisum sativum) proteins from six genotypes grown in Serbia were investigated. Also, the relationship between these characteristics was presented. Investigated genotypes showed significant differences in storage protein content, composition and extractability. The ratio of vicilin:legumin concentrations, as well as the ratio of vicilin + convicilin: Legumin concentrations were positively correlated with extractability. Our data suggest that the higher level of vicilin and/or a lower level of legumin have a positive influence on protein extractability. The emulsion activity index (EAI) was strongly and positively correlated with the solubility, while no significant correlation was found between emulsion stability (ESI) and solubility, nor between foaming properties and solubility. No association was evident between ESI and EAI. A moderate positive correlation between emulsion stability and foam capacity was observed. Proteins from the investigated genotypes expressed significantly different emulsifying properties and foam capacity at different pH values, whereas low foam stability was detected. It appears that genotype has considerable influence on content, composition and technological-functional properties of pea bean proteins. This fact can be very useful for food scientists in efforts to improve the quality of peas and pea protein products. PMID:21614186

Profile and functional properties of seed proteins from six pea (Pisum sativum) genotypes.

PubMed

Barac, Miroljub; Cabrilo, Slavica; Pesic, Mirjana; Stanojevic, Sladjana; Zilic, Sladjana; Macej, Ognjen; Ristic, Nikola

2010-01-01

Extractability, extractable protein compositions, technological-functional properties of pea (Pisum sativum) proteins from six genotypes grown in Serbia were investigated. Also, the relationship between these characteristics was presented. Investigated genotypes showed significant differences in storage protein content, composition and extractability. The ratio of vicilin:legumin concentrations, as well as the ratio of vicilin + convicilin: Legumin concentrations were positively correlated with extractability. Our data suggest that the higher level of vicilin and/or a lower level of legumin have a positive influence on protein extractability. The emulsion activity index (EAI) was strongly and positively correlated with the solubility, while no significant correlation was found between emulsion stability (ESI) and solubility, nor between foaming properties and solubility. No association was evident between ESI and EAI. A moderate positive correlation between emulsion stability and foam capacity was observed. Proteins from the investigated genotypes expressed significantly different emulsifying properties and foam capacity at different pH values, whereas low foam stability was detected. It appears that genotype has considerable influence on content, composition and technological-functional properties of pea bean proteins. This fact can be very useful for food scientists in efforts to improve the quality of peas and pea protein products.

Unraveling Exercise Addiction: The Role of Narcissism and Self-Esteem

PubMed Central

Cicciarelli, Claudio; Romeo, Vincenzo Maria; Pandolfo, Gianluca

2014-01-01

The aim of this study was to assess the risk of exercise addiction (EA) in fitness clubs and to identify possible factors in the development of the disorder. The Exercise Addiction Inventory (EAI), the Narcissistic Personality Inventory (NPI), and the Coopersmith Self-Esteem Inventory (SEI) were administered to a sample of 150 consecutive gym attenders recruited in fitness centers. Based on EAI total score, high EA risk group (HEA n = 51) and a low EA risk group (LEA n = 69) were identified. HEA reported significantly higher total score (mean = 20.2 versus 14.6) on the NPI scale and lower total score (mean = 32.2 versus 36.4) on the SEI scale than LEA. A stepwise regression analysis indicated that only narcissism and self-esteem total scores (F = 5.66; df = 2; P = 0.006) were good predictors of days per week exercise. The present study confirms the direct and combined role of both labile self-esteem and high narcissism in the development of exercise addiction as predictive factors towards the risk of addiction. Multidisciplinary trained health care providers (physiatrists, psychologists, and psychiatrists) should carefully identify potential overexercise conditions in order to prevent the potential risk of exercise addiction. PMID:25405056

Biological and Economic Productivity of Mixed-Aged Loblolly Pine Stands in the South

Treesearch

Ronald Raunikar; Joseph Buongiorno; Jeffrey P. Prestemon; Karen Lee-Abt

1999-01-01

The financial performance of the 991 sample plots of uneven-aged loblolly-hardwood stands in the Central South FIA database examined in this report depend crucially on real price trends. Equivalent annual income (EAI) is the measure of economic performance. The regional market stumpage price data are from the Timber Mart-South database. For this set of prices, a...

Sensitivity of Pliocene ice sheets to orbital forcing

USGS Publications Warehouse

Dolan, A.M.; Haywood, A.M.; Hill, D.J.; Dowsett, H.J.; Hunter, S.J.; Lunt, D.J.; Pickering, S.J.

2011-01-01

The stability of the Earth's major ice sheets is a critical uncertainty in predictions of future climate and sea level change. One method of investigating the behaviour of the Greenland and the Antarctic ice sheets in a warmer-than-modern climate is to look back at past warm periods of Earth history, for example the Pliocene. This paper presents climate and ice sheet modelling results for the mid-Pliocene warm period (mPWP; 3.3 to 3.0 million years ago), which has been identified as a key interval for understanding warmer-than-modern climates (Jansen et al., 2007). Using boundary conditions supplied by the United States Geological Survey PRISM Group (Pliocene Research, Interpretation and Synoptic Mapping), the Hadley Centre coupled ocean–atmosphere climate model (HadCM3) and the British Antarctic Survey Ice Sheet Model (BASISM), we show large reductions in the Greenland and East Antarctic Ice Sheets (GrIS and EAIS) compared to modern in standard mPWP experiments. We also present the first results illustrating the variability of the ice sheets due to realistic orbital forcing during the mid-Pliocene. While GrIS volumes are lower than modern under even the most extreme (cold) mid-Pliocene orbit (losing at least 35% of its ice mass), the EAIS can both grow and shrink, losing up to 20% or gaining up to 10% of its present-day volume. The changes in ice sheet volume incurred by altering orbital forcing alone means that global sea level can vary by more than 25 m during the mid-Pliocene. However, we have also shown that the response of the ice sheets to mPWP orbital hemispheric forcing can be in anti-phase, whereby the greatest reductions in EAIS volume are concurrent with the smallest reductions of the GrIS. If this anti-phase relationship is in operation throughout the mPWP, then the total eustatic sea level response would be dampened compared to the ice sheet fluctuations that are theoretically possible. This suggests that maximum eustatic sea level rise does not correspond to orbital maxima, but occurs at times where the anti-phasing of Northern and Southern Hemisphere ice sheet retreat is minimised.

Signature-tagged mutagenesis in a chicken infection model leads to the identification of a novel avian pathogenic Escherichia coli fimbrial adhesin.

PubMed

Antão, Esther-Maria; Ewers, Christa; Gürlebeck, Doreen; Preisinger, Rudolf; Homeier, Timo; Li, Ganwu; Wieler, Lothar H

2009-11-12

The extraintestinal pathogen, avian pathogenic E. coli (APEC), known to cause systemic infections in chickens, is responsible for large economic losses in the poultry industry worldwide. In order to identify genes involved in the early essential stages of pathogenesis, namely adhesion and colonization, Signature-tagged mutagenesis (STM) was applied to a previously established lung colonization model of infection by generating and screening a total of 1,800 mutants of an APEC strain IMT5155 (O2:K1:H5; Sequence type complex 95). The study led to the identification of new genes of interest, including two adhesins, one of which coded for a novel APEC fimbrial adhesin (Yqi) not described for its role in APEC pathogenesis to date. Its gene product has been temporarily designated ExPEC Adhesin I (EA/I) until the adhesin-specific receptor is identified. Deletion of the ExPEC adhesin I gene resulted in reduced colonization ability by APEC strain IMT5155 both in vitro and in vivo. Furthermore, complementation of the adhesin gene restored its ability to colonize epithelial cells in vitro. The ExPEC adhesin I protein was successfully expressed in vitro. Electron microscopy of an afimbriate strain E. coli AAEC189 over-expressed with the putative EA/I gene cluster revealed short fimbrial-like appendages protruding out of the bacterial outer membrane. We observed that this adhesin coding gene yqi is prevalent among extraintestinal pathogenic E. coli (ExPEC) isolates, including APEC (54.4%), uropathogenic E. coli (UPEC) (65.9%) and newborn meningitic E. coli (NMEC) (60.0%), and absent in all of the 153 intestinal pathogenic E. coli strains tested, thereby validating the designation of the adhesin as ExPEC Adhesin I. In addition, prevalence of EA/I was most frequently associated with the B2 group of the EcoR classification and ST95 complex of the multi locus sequence typing (MLST) scheme, with evidence of a positive selection within this highly pathogenic complex. This is the first report of the newly identified and functionally characterized ExPEC adhesin I and its significant role during APEC infection in chickens.

Financial Performance of Mixed-Age Naturally Regenerated Loblolly-Hardwood Stands in the South Central United States

Treesearch

Ronald Raunikar; Joseph Buongiorno; Jeffrey P. Prestemon; Karen Lee Abt

2000-01-01

To estimate the financial performance of a natural mixed species and mixed-age management in the loblolly-pine forest type, we examined 991 FIA plots in the south central states. The plots were of the loblolly pine forest type, mixed-age, and had been regenerated naturally. We gauged the financial performance of each plot from the equivalent annual income (EAI)...

Simulating (log(c) n)-wise Independence in NC

DTIC Science & Technology

1989-05-01

independent) distribution. However, Xk (A) = (1x(I))k = Z Z y (i,)...X(ik). iEA ijEAi 2 EA IkEA So Lemma 2.4 applies to show that any k-wise independent...AEA AEAi1EA ikEA So henceforth we want an X such that F(X) >_ E[F(X)]. 2.5 Generating k-Wise Independent Variables It still remains to demonstrate a k

COED Transactions, Vol. IX, No. 1, January 1977. Rapid Production of System Phase-Plane Portraits on the EAI 380 Hybrid/Analog Computer.

ERIC Educational Resources Information Center

Marcovitz, Alan B., Ed.

The method of phase-plane presentation as an educational tool in the study of the dynamic behavior of systems is discussed. In the treatment of nonlinear or piecewise-linear systems, the phase-plane portrait is used to exhibit the nature of singular points, regions of stability, and switching lines to aid comprehension. A technique is described by…

Functional properties and in vitro trypsin digestibility of red kidney bean (Phaseolus vulgaris L.) protein isolate: Effect of high-pressure treatment.

PubMed

Yin, Shou-Wei; Tang, Chuan-He; Wen, Qi-Biao; Yang, Xiao-Quan; Li, Lin

2008-10-15

The effects of high-pressure (HP) treatment at 200-600MPa, prior to freeze-drying, on some functional properties and in vitro trypsin digestibility of vicilin-rich red kidney bean (Phaseolus vulgaris L.) protein isolate (KPI) were investigated. Surface hydrophobicity and free sulfhydryl (SH) and disulfide bond (SS) contents were also evaluated. HP treatment resulted in gradual unfolding of protein structure, as evidenced by gradual increases in fluorescence strength and SS formation from SH groups, and decrease in denaturation enthalpy change. The protein solubility of KPI was significantly improved at pressures of 400MPa or higher, possibly due to formation of soluble aggregate from insoluble precipitate. HP treatment at 200 and 400MPa significantly increased emulsifying activity index (EAI) and emulsion stability index (ESI); however, EAI was significantly decreased at 600MPa (relative to untreated KPI). The thermal stability of the vicilin component was not affected by HP treatment. Additionally, in vitro trypsin digestibility of KPI was decreased only at a pressure above 200MPa and for long incubation time (e.g., 120min). The data suggest that some physiochemical and functional properties of vicilin-rich kidney proteins can be improved by means of high-pressure treatment. Copyright © 2008 Elsevier Ltd. All rights reserved.

The connection between exercise addiction and orthorexia nervosa in German fitness sports.

PubMed

Rudolph, Sabrina

2017-09-07

The combination of physical activity and healthy eating habits has potentially positive effects on health. However, both practices can also lead to pathological behaviors such as exercise addiction (EA) and orthorexia nervosa (ON), thus generating negative effects. So far, studies analyzing the connection between these two phenomena cannot be found. The current paper is aiming to close this gap. The sample (n = 1.008) consisted of 559 male and 449 female active members of three fitness studios, and was analyzed in a cross-sectional study design. The Exercise Addiction Inventory (EAI) was used to establish exercise addiction and the Düsseldorfer Orthorexie Skala (DOS) was used to evaluate orthorectic eating behavior. Out of the whole sample, 10.2% exhibit EA, while ON is prevalent in 3.4%. Twenty-three (2.3%) individuals suffer from both. There is a significant positive correlation between DOS and EAI (p < .001, r = .421). Female participants (p < .001, r = .452) show a higher correlation compared to male participants (p < .001, r = .418). The results suggest a positive correlation between ON and EA in the context of German fitness sports. Both seem to be serious phenomena and require further investigation. Level V (cross-sectional descriptive study).

Construction of a parallel processor for simulating manipulators and other mechanical systems

NASA Technical Reports Server (NTRS)

Hannauer, George

1991-01-01

This report summarizes the results of NASA Contract NAS5-30905, awarded under phase 2 of the SBIR Program, for a demonstration of the feasibility of a new high-speed parallel simulation processor, called the Real-Time Accelerator (RTA). The principal goals were met, and EAI is now proceeding with phase 3: development of a commercial product. This product is scheduled for commercial introduction in the second quarter of 1992.

Disability Evaluation System and Temporary Limited Duty Assignment Process: A Qualitative Review.

DTIC Science & Technology

1998-03-01

Statement addressing the requirement for monitoring, frequency of treat- ments/ therapy , and the associated operational assignment limitation; Informed...ACC does not exist in the EAIS, ARIS, or the EMF data bases. The system is able to track changes in duty station, but not ACC’s. If a member is on...specific geographic assignment. 4. Requires extensive or prolonged medical therapy . 5. Who through continued military service would probably result in

Comparison of enzymatic activities in different Candida species isolated from women with vulvovaginitis.

PubMed

Fatahinia, M; Halvaeezadeh, M; Rezaei-Matehkolaei, A

2017-06-01

Comparing the activities of secreted enzymes in different fungal species can improve our understanding of their pathogenic role. Secretion of various enzymes by Candida species has been considered for determination of their virulence in different Candida infections including vulvovaginitis. The aim of this study was to determine and compare the activity of secreted enzymes in Candidia strains isolated from women suspected to vulvovaginal candidiasis (VVC) and referred to some health centers in Khuzestan, Southwestern Iran. The vaginal secretion samples were taken by swap from 250 suspected women with symptoms of vulvovaginal candidiasis and cultured on CHROMagar Candida medium. Identification of the isolated Candida from culture positive samples performed by the color of colonies and some standard mycological procedures. Activities of phospholipase, hemolysin-α, hemolysin-β, esterase and proteinase were measured in vitro by standard laboratory protocols. The enzymatic activity index (EAI) was calculated for each enzyme in accordance to relevant protocols. Totally in eighty cases (32%), a Candida strain was isolated which found to be as 52 (65%) Candida albicans; 12 (15%) C. glabrata; 10 (12.5%) C. dubliniensis; 4 (5%) C. krusei, C. tropicalis and C. parapsilosis species (each=1; 1.3%). Among C. albicans strains, 89.1% produced all studied enzymes, while 86% of C. glabrata strains failed to produce proteinase and phospholipase. The EAIs in decreasing order were as hemolysin-β=0.2895, hemolysin-α=0.5420, esterase=0.5753, proteinase=0.7413, and phospholipase=0.7446, respectively. Activity of phospholipase, esterase and proteinase secreted by C. albicans and C. dubliniensis were significantly more than those released by C. glabrata and C. krusei, while 86% of C. glabrata strains did not show esterase activity. On the other hand, the activity rates of hemolysin α and β among all studied isolates were almost similar. In the present study, the prevalence of VVC among investigated women was higher than the previous report from Khuzestan but C. albicans has yet remained the predominant agent of VVC in this area. Given to the EAI, the virulence of C. albicans in VVC can be mediated by phospholipase, esterase and proteinases. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Subglacial sedimentary basin characterization of Wilkes Land, East Antarctica via applied aerogeophysical inverse methods

NASA Astrophysics Data System (ADS)

Frederick, B. C.; Gooch, B. T.; Richter, T.; Young, D. A.; Blankenship, D. D.; Aitken, A.; Siegert, M. J.

2013-12-01

Topography, sediment distribution and heat flux are all key boundary conditions governing the stability of the East Antarctic ice sheet (EAIS). Recent scientific scrutiny has been focused on several large, deep, interior EAIS basins including the submarine basal topography characterizing the Aurora Subglacial Basin (ASB). Numerical ice sheet models require accurate deformable sediment distribution and lithologic character constraints to estimate overall flow velocities and potential instability. To date, such estimates across the ASB have been derived from low-resolution satellite data or historic aerogeophysical surveys conducted prior to the advent of GPS. These rough basal condition estimates have led to poorly-constrained ice sheet stability models for this remote 200,000 sq km expanse of the ASB. Here we present a significantly improved quantitative model characterizing the subglacial lithology and sediment in the ASB region. The product of comprehensive ICECAP (2008-2013) aerogeophysical data processing, this sedimentary basin model details the expanse and thickness of probable Wilkes Land subglacial sedimentary deposits and density contrast boundaries indicative of distinct subglacial lithologic units. As part of the process, BEDMAP2 subglacial topographic results were improved through the additional incorporation of ice-penetrating radar data collected during ICECAP field seasons 2010-2013. Detailed potential field data pre-processing was completed as well as a comprehensive evaluation of crustal density contrasts based on the gravity power spectrum, a subsequent high pass data filter was also applied to remove longer crustal wavelengths from the gravity dataset prior to inversion. Gridded BEDMAP2+ ice and bed radar surfaces were then utilized to establish bounding density models for the 3D gravity inversion process to yield probable sedimentary basin anomalies. Gravity inversion results were iteratively evaluated against radar along-track RMS deviation and gravity and magnetic depth to basement results. This geophysical data processing methodology provides a substantial improvement over prior Wilkes Land sedimentary basin estimates yielding a higher resolution model based upon iteration of several aerogeophysical datasets concurrently. This more detailed subglacial sedimentary basin model for Wilkes Land, East Antarctica will not only contribute to vast improvements on EAIS ice sheet model constraints, but will also provide significant quantifiable controls for subglacial hydrologic and geothermal flux estimates that are also sizable contributors to the cold-based, deep interior basal ice dynamics dominant in the Wilkes Land region.

K/Ar Dating of Fine Grained Sediments Near Prydz Bay, Antarctica: East Antarctic Ice Sheet Behavior During the Middle-Miocene Climate Transition

NASA Astrophysics Data System (ADS)

Duchesne, A. E.; Pierce, E. L.; Williams, T.; Hemming, S. R.; Johnson, D. L.; May, T.; Gombiner, J.; Torfstein, A.

2012-12-01

¶ The Middle Miocene Climate Transition (MMCT) (~14 Ma) represents a time of major East Antarctic Ice-Sheet (EAIS) expansion, with research suggesting major global sea level fall on the order of ~60 meters (John et al., 2011, EPSL). Ocean Drilling Program (ODP) core data from Site 1165B near Prydz Bay shows an influx of cobbles deposited ~13.8-13.5 Ma, representing a sudden burst of ice-rafted detritus (IRD) during the MMCT. Based on 40Ar/39Ar dating of hornblendes and/or biotite grains, 5 of 6 dated pebbles from a companion study show Wilkes Land origins, indicating transport from over 1500 kilometers away. However, samples throughout this time interval have an anomalously low abundance of sand, thus we seek to understand the sedimentary processes that led to the deposition of these isolated dropstones in a fine matrix through provenance studies of the core's terrigenous fine fraction. Geochemical provenance studies of the terrigenous fraction of marine sediments can aid in identifying past dynamic EAIS behavior; the few outcrops available on the continent provide specific rock characterizations and age constraints from which cored marine sediments can then be matched to using established radiogenic isotope techniques. Here we apply the K/Ar dating method as a provenance tool for identifying the source area(s) of fine-grained terrigenous sediments (<63 μm) deposited during the MMCT. ¶ After source area characterization, we find that the fine-grained sediments from the mid-Miocene show a mixture of both local Prydz Bay sourcing (~400 Ma signature) and Wilkes Land provenance (~900 Ma signature). While locally-derived Prydz Bay sediments are likely to have been delivered via meltwater from ice and deposited as hemipelagic sediments (with some possible bottom current modification, as this is a drift site), sediments sourced from Wilkes Land required transport via large icebergs. Future work will involve further provenance determination on both the fine-grained sediments and the abundant dropstones deposited at ODP Site 1165B during the MMCT. We anticipate that the use of the K/Ar radiometric dating technique as a proxy for the study of glacially transported fine-grained terrigenous materials will enable future Antarctic provenance research and further aid in providing insight into past EAIS behavior.; ODP Core 34X from Site 1165B

Functional Properties of Pea (Pisum sativum, L.) Protein Isolates Modified with Chymosin

PubMed Central

Barać, Miroljub; Čabrilo, Slavica; Pešić, Mirjana; Stanojević, Slađana; Pavlićević, Milica; Maćej, Ognjen; Ristić, Nikola

2011-01-01

In this paper, the effects of limited hydrolysis on functional properties, as well as on protein composition of laboratory-prepared pea protein isolates, were investigated. Pea protein isolates were hydrolyzed for either 15, 30 and 60 min with recombined chymosin (Maxiren). The effect of enzymatic action on solubility, emulsifying and foaming properties at different pH values (3.0; 5.0; 7.0 and 8.0) was monitored. Chymosin can be a very useful agent for improvement of functional properties of isolates. Action of this enzyme caused a low degree of hydrolysis (3.9–4.7%), but improved significantly functional properties of pea protein isolates (PPI), especially at lower pH values (3.0–5.0). At these pH values all hydrolysates had better solubility, emulsifying activity and foaming stability, while longer-treated samples (60 min) formed more stable emulsions at higher pH values (7.0, 8.0) than initial isolates. Also, regardless of pH value, all hydrolysates showed improved foaming ability. A moderate positive correlation between solubility and emulsifying activity index (EAI) (0.74) and negative correlation between solubility and foam stability (−0.60) as well as between foam stability (FS) and EAI (−0.77) were observed. Detected enhancement in functional properties was a result of partial hydrolysis of insoluble protein complexes. PMID:22272078

Genetic diversity of Mycobacterium tuberculosis isolates from central India.

PubMed

Desikan, Prabha; Chauhan, D S; Sharma, Pragya; Panwalkar, Nikita; Chourey, Manju; Patidar, Mohan Lal; Yadav, Priyanka; Chandrasekaran, V; Ohri, B S

2016-04-01

There is a paucity of data available on genetic biodiversity of Mycobacterium tuberculosis isolates from central India. The present study was carried out on isolates of M. tuberculosis cultured from diagnostic clinical samples of patients from Bhopal, central India, using spoligotyping as a method of molecular typing. DNA was extracted from 340 isolates of M. tuberculosis from culture, confirmed as M. tuberculosis by molecular and biochemical methods and subjected to spoligotyping. The results were compared with the international SITVIT2 database. Sixty five different spoligo international type (SIT) patterns were observed. A total of 239 (70.3%) isolates could be clustered into 25 SITs. The Central Asian (CAS) and East African Indian (EAI) families were found to be the two major circulating families in this region. SIT26/CAS1_DEL was identified as the most predominant type, followed by SIT11/EAI3_IND and SIT288/CAS[2]. Forty (11.8%) unique (non-clustered) and 61 (17.9%) orphan isolates were identified in the study. There was no significant association of clustering with clinical and demographic characteristics of patients. Well established SITs were found to be predominant in our study. SIT26/CAS1_DEL was the most predominant type. However, the occurrence of a substantial number of orphan isolates may indicate the presence of active spatial and temporal evolutionary dynamics within the isolates of M. tuberculosis.

Whole Genome Sequencing Demonstrates Limited Transmission within Identified Mycobacterium tuberculosis Clusters in New South Wales, Australia

PubMed Central

Gurjav, Ulziijargal; Outhred, Alexander C.; Jelfs, Peter; McCallum, Nadine; Wang, Qinning; Hill-Cawthorne, Grant A.; Marais, Ben J.; Sintchenko, Vitali

2016-01-01

Australia has a low tuberculosis incidence rate with most cases occurring among recent immigrants. Given suboptimal cluster resolution achieved with 24-locus mycobacterium interspersed repetitive unit (MIRU-24) genotyping, the added value of whole genome sequencing was explored. MIRU-24 profiles of all Mycobacterium tuberculosis culture-confirmed tuberculosis cases diagnosed between 2009 and 2013 in New South Wales (NSW), Australia, were examined and clusters identified. The relatedness of cases within the largest MIRU-24 clusters was assessed using whole genome sequencing and phylogenetic analyses. Of 1841 culture-confirmed TB cases, 91.9% (1692/1841) had complete demographic and genotyping data. East-African Indian (474; 28.0%) and Beijing (470; 27.8%) lineage strains predominated. The overall rate of MIRU-24 clustering was 20.1% (340/1692) and was highest among Beijing lineage strains (35.7%; 168/470). One Beijing and three East-African Indian (EAI) clonal complexes were responsible for the majority of observed clusters. Whole genome sequencing of the 4 largest clusters (30 isolates) demonstrated diverse single nucleotide polymorphisms (SNPs) within identified clusters. All sequenced EAI strains and 70% of Beijing lineage strains clustered by MIRU-24 typing demonstrated distinct SNP profiles. The superior resolution provided by whole genome sequencing demonstrated limited M. tuberculosis transmission within NSW, even within identified MIRU-24 clusters. Routine whole genome sequencing could provide valuable public health guidance in low burden settings. PMID:27737005

The last deglacial retreat history of the East Antarctic Ice Sheet recorded in sediments from off the Wilkes Land Coast

NASA Astrophysics Data System (ADS)

Yokoyama, Y.; Yamane, M.; Miyairi, Y.; Suga, H.; Dunbar, R. B.; Ohkouchi, N.

2017-12-01

Timing of past ice sheet retreat of Antarctic continent has been debated with regards to the global sea level changes since the Last Glacial Maximum (LGM) centered at around 20 ka. Exposure dating using cosmogenic radio nuclide (CRN) for glacial deposits have been widely used to reconstruct the last deglacial history though this cannot apply where no-ice free coasts are existed. One such location is the Wilkes Land where the East Antarctic Ice Sheet (EAIS) is situated directory on seafloor. Sediment cores obtained off the Wilkes Land coast successfully retrieved cores during the Intergrated Ocean Drilling Program (IODP) Expedition 318 (Escuita et al., 2011). Major obstacle to obtain reliable chronology for marine cores around Antarctica is sparsity of carbonate materials such as foraminifera. Thus compound-specific radiocarbon analysis (CSRA) has been used and we applied CSRA to the sediments obtained off the Wilkes land coast. The CSRA targeted C16 and C16:1 fatty acid due to their high degradation rate. Hence low concentrations of these compounds are expected. We found major sedimentation occurred since the beginning of Holocene. The result is then compared to the previously reported dates from the land based CRN dates (eg., Mckintosh et al., 2013; Yamane et al., 2011) to discuss the timing of retreat of EAIS.

Intelligent Elements for ISHM

NASA Technical Reports Server (NTRS)

Schmalzel, John L.; Morris, Jon; Turowski, Mark; Figueroa, Fernando; Oostdyk, Rebecca

2008-01-01

There are a number of architecture models for implementing Integrated Systems Health Management (ISHM) capabilities. For example, approaches based on the OSA-CBM and OSA-EAI models, or specific architectures developed in response to local needs. NASA s John C. Stennis Space Center (SSC) has developed one such version of an extensible architecture in support of rocket engine testing that integrates a palette of functions in order to achieve an ISHM capability. Among the functional capabilities that are supported by the framework are: prognostic models, anomaly detection, a data base of supporting health information, root cause analysis, intelligent elements, and integrated awareness. This paper focuses on the role that intelligent elements can play in ISHM architectures. We define an intelligent element as a smart element with sufficient computing capacity to support anomaly detection or other algorithms in support of ISHM functions. A smart element has the capabilities of supporting networked implementations of IEEE 1451.x smart sensor and actuator protocols. The ISHM group at SSC has been actively developing intelligent elements in conjunction with several partners at other Centers, universities, and companies as part of our ISHM approach for better supporting rocket engine testing. We have developed several implementations. Among the key features for these intelligent sensors is support for IEEE 1451.1 and incorporation of a suite of algorithms for determination of sensor health. Regardless of the potential advantages that can be achieved using intelligent sensors, existing large-scale systems are still based on conventional sensors and data acquisition systems. In order to bring the benefits of intelligent sensors to these environments, we have also developed virtual implementations of intelligent sensors.

Interdisciplinary Program for Quantitative Flaw Definition Second Year Effort

DTIC Science & Technology

1976-08-01

this case (1) reduces to V- Se T (3a) r eai T r- SaaTi (3b) For this case Sea is readily identified as the acoustic to electrical conversion factor...techniques that were developed to measure the S-parameters it is useful to first go back and re-evaluate the nature of the parameters Sea and Sae of...Essentially, Sea and Sae contain a factor which relates the conversion of units that is inherent to the transduction process. To see this in more

U.S. Army Medical Research Institute of Infectious Diseases Annual Report, Fiscal Year 1986

DTIC Science & Technology

1986-10-01

determined. SUMMARY Strains of mice sensitive (A/J) and resistant (C3H/HeN) to C. burnetii were given varying doses of the phase 1, 9 Mile isolate...ASSOCIATE INVESTIGATORS: J. W. Ezzell , Ph.D. B. E. Ivins, Ph.D. As previously reported by Dr. Ezzell , a 93-kd extractable protein (EAI) is the principal...challenge. The following work has been carried out by Dr. Bruce Ivins in cooperation with Susan Welkos, Steve Little, John Ezzell , and Greg Knudson of

Electrochemical Behavior and Surface Chemistry of Nonequilibrium Aluminum Alloys: Passivity Mechanism and Fabrication Methods

DTIC Science & Technology

1994-01-17

alartl.rdentifvb bjock nurrber) FtELD GROUP SUB-GROUP Appreveo for LUDic release; OSirlOUtion unllmilTe. Reproduction in whole or in part is pemitted for any...INSPECTED 5 0eeesson For Mr.c EAi 0 Justi fioaL fo p ,l INTRODUCTION Aluminum alloys are generally designed for improved mechanical properties which...during spraying. The specifications for these samples are given in Table 1. In this report, W concentrations used to denote samples refer to design

Late Holocene sedimentation in coastal areas of the northwestern Ross Sea (Antarctica)

NASA Astrophysics Data System (ADS)

Colizza, Ester; Finocchiaro, Furio; Kuhn, Gerhard; Langone, Leonardo; Melis, Romana; Mezgec, Karin; Severi, Mirko; Traversi, Rita; Udisti, Roberto; Stenni, Barbara; Braida, Martina

2013-04-01

Sediment cores and box cores collected in two coastal areas of the northwestern Ross Sea (Antarctica) highlight the possibility of studying the Late Holocene period in detail. In this work we propose a study on two box cores and two gravity cores collected in the Cape Hallett and Wood Bay areas during the 2005 PNRA oceanographic cruise. The two sites are feed by Eastern Antarctic Ice Shelf (EAIS) and previous studies have highlighted a complex postglacial sedimentary sequence, also influenced by local morphology. This study is performed within the framework of the PNRA-ESF PolarCLIMATE HOLOCLIP (Holocene climate variability at high-southern latitudes: an integrated perspective) Project. The data set includes: magnetic susceptibility, X-ray analyses, 210Pb, 14C dating, diatoms and foraminifera assemblages, organic carbon, and grain-size analyses. Furthermore XRF core scanner analyses, colour analysis from digital images, and major, minor and trace element concentration analyses (ICP-AES) are performed. Data show that the box core and upper core sediments represent a very recent sedimentation in which it is possible to observe the parameter variability probably linked to climate variability/changes: these variation will be compared with isotopic record form ice cores collected form the same Antarctic sector.

[Exercise addiction: an emergent behavioral disorder].

PubMed

Márquez, Sara; de la Vega, Ricardo

2015-06-01

Regular physical activity plays a relevant role in health maintenance and disease prevention. However, excess exercise may generate adverse effects both on physical and mental activity. To provide a state-of-the-art overview on exercise addiction, considering its concept, symptoms, diagnosis, epidemiological aspects, etiological factors, and potential interventions. Articles related to the topic were reviewed through Pubmed, Sportdiscus, PsycINFO, Scopus and Web of Science databases, using combinations of the following keywords: "exercise", "addiction" and "dependence". Regular exercise taken into excess may result in adverse health consequences and quality of life impairment. Diagnosis of exercise addiction requires the employment of questionnaires such as the Exercise Dependence Scale (EDS) and the Exercise Addiction Inventory (EAI). These instruments have allowed the estimation of a 3% prevalence among exercise practitioners. Proposed hypotheses to explain the etiology of this disorder include both physiological and psychological mechanisms. Treatment is based on the cognitive-behavioral approach, but effectiveness needs to be evaluated. Although different hypotheses have been proposed to explain exercise dependence, integrative models are still necessary. A clinical validation of diagnostic instruments and a deepening into the relationship with behavioral eating disorders are also required. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Exercise addiction in men is associated with lower fat-adjusted leptin levels.

PubMed

Lichtenstein, Mia B; Andries, Alin; Hansen, Stinus; Frystyk, Jan; Støving, René K

2015-03-01

To test a hypothesized association between resting leptin levels (adjusted for body fat percentage) and symptoms of primary exercise addiction. Cross-sectional design. Habitual amateur exercisers participating in running, fitness, weight training, and biking. Twenty men with exercise addiction as defined by the Exercise Addiction Inventory (EAI scores 24-30) and 20 men in an exercise control group (EAI scores 6-16) matched on body mass index. Plasma leptin and sex hormones were measured in blood samples collected under fasting and resting conditions. Body composition was assessed by dual-energy x-ray absorptiometry. Eating disorder symptoms were identified by the Eating Disorder Inventory 2. The exercise addiction group had significantly (P < 0.001) lower leptin levels (1.1 μg/L, SD = 1.3) than controls (4.3 μg/L, SD = 2.9). Even when adjusted for body fat percentage, the addiction group had significantly (P < 0.001) lower leptin levels (0.1 μg/L, SD = 0.1) than the controls (0.2 μg/L, SD = 0.1). Body fat-adjusted leptin correlated with free bioavailable testosterone, but it was only significant in nonaddictive exercisers. None of the exercisers seemed to suffer from an eating disorder. This is the first study showing that excessive training in exercise addiction is associated with low levels of body fat-adjusted leptin levels. Hypoleptinemia could be involved in the pathogenesis of exercise addiction. However, further studies are needed to explore the potential causal relationship.

Preparation and characterisation of protein hydrolysates from Indian defatted rice bran meal.

PubMed

Bandyopadhyay, Kakali; Misra, Gautam; Ghosh, Santinath

2008-01-01

Rice bran meal is a very good source of protein along with other micronutrients. Rice bran meal has been utilized to produce protein isolates and respective protein hydrolysates for potential application in various food products. De-oiled rice bran meal, available from Indian rice bran oil extraction plants, was initially screened by passing through an 80-mesh sieve (yield about 70%). A fraction (yield-30%) rich in fibre and silica was initially discarded from the meal. The protein content of the through fraction increased from 20.8% to 24.1% whereas silica content reduced from 3.1% to 0.4%. Rice bran protein isolate (RPI) was prepared by alkaline extraction followed by acidic precipitation at isoelectric point. This protein isolate was hydrolysed by papain at pH 8.0 and at 37 degrees C for 10, 20, 30, 45 and 60 minutes. The peptides produced by partial hydrolysis had been evaluated by determining protein solubility, emulsion activity index (EAI), emulsion stability index (ESI), foam capacity and foam stability (FS). All protein hydrolysates showed better functional properties than the original protein isolate. These improved functional properties of rice bran protein hydrolysates would make it useful for various application especially in food, pharmaceutical and related industries.

Reconstructing paleoceanographic conditions during the Oligocene/Miocene Boundary using walled dinoflagellate cysts and TEX86: IODP Expedition 318, Wilkes Land, Antarctic margin

NASA Astrophysics Data System (ADS)

Bijl, Peter; Bruls, Anja; Hartman, Julian D.; Sangiorgi, Francesca; Peterse, Francien

2017-04-01

Wilkes land is potentially a sensitive sector of the East Antarctic Ice Sheet (EAIS), because Wilkes subglacial basin is largely below sea level. In light of this, understanding changes in ice volume in this sector of Antarctica during past episodes of warmth may help constrain future ice sheet melt in the region. Integrated Ocean Drilling Program Expedition 318 was intended to drill and recover from the Wilkes Land continental Margin to reconstruct the history of the East Antarctic ice sheet (EAIS). The integrated bio-magnetostratigraphic age model for IODP Site U1356 is quite robust for the entire stratigraphic record, but in the Oligocene-Miocene boundary interval, the details of the age model are somewhat elusive. Notably it is uncertain whether sediments dating back to the Mi-1 glaciation event, at the Oligocene-Miocene boundary, are represented in the record. This research presents a revised age model for the interval around the OMT and gives a paleoceanographic interpretation of Site U1356 based on dinocyst ecology and TEX86 biomarker proxy. The finding of the dinocyst species Edwardsiella sexispinosa provides for an additional dinocyst event, and revised the location of the OMT. Core 45R likely represents the base of the Miocene and Core 46R and Core 47R represents the late Oligocene between 23.23 to 25.1 Ma. The dinocyst ecology indicated varying intervals of mostly Protoperidinioid genera to mostly Gonyaulacoid genera, that represent high productivity conditions and oligotrophic conditions respectively. These changing ecological conditions have been related to the a changing upwelling regime along the Wilkes Land margin, which is connected to the polar wind field and positively correlated to the extent of the Antarctic ice sheets. Sea ice conditions are absent along the Wilkes Land margin throughout this part of the record, therefore deep-water formation would also have been reduced. The SST record provided by TEX86 biomarker proxy indicates a decreasing trend towards the Miocene, but does not seem to point consistently to a warmer climate state during the late Oligocene. The dinocyst and TEX86 records seem to infer a smaller than present, dynamic Antarctic ice sheet during the late Oligocene to early Miocene, yet in combination with a quite invariant state of the atmospheric pCO2 record (Zhang et al., 2013). This seems to indicate a more sensitive Antarctic ice sheet possibly related to a threshold size for a stable ice sheet. However the ice volume changes inferred from the global benthic foraminiferal δ18O record could also have been of a smaller extent. Another cause that could potentially add to the changing δ18O record, is a change in deep water source, more specifically an alternating Southern Ocean deep-water formation which is coupled to the alternating Antarctic cryosphere.

Observations of the California Countercurrent.

DTIC Science & Technology

1984-06-01

m S. P. Tucker Approved for public release; distribut ion tin] imi ted. UnCLASS IFIED W S4(CWftIY CLASSIVICATIOkO r 7.1% PAGE "Wh., Owe Ent.,eai...Idtinity by block number) - -R6sults from moored current meters, 150-350 m , Uru describec~for ai region over the continental slope off Cape San Martin...from ,.ored current net e r 15) - 35q m , are z2-CUS.eJ tar a region over th1e continental _sioLp, .2 "a,, .San rrtin, Cali orn ra . .I nLlarv 1979 to

Equal Access Initiative HIV/AIDS Information Resources from NLM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Templin-Branner W. and N. Dancy

The Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the National Minority AIDS Council 2010 Equal Access Initiative (EAI) Computer Grants Program awardees to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based

Fuel Cell Power System and Equipment Bay for High Altitude, Super- Pressured, Powered Aerostat (HASPA) Operational Manual

DTIC Science & Technology

1975-05-20

across the anode side of the membrane -electrode assembly. Flow distribution of the hydrogen gas from cell to cell is not a problem as that system is...DOCUMENTATION PAGE RiEAI T C OMPLETING FORM V ~i 12.BR NUMVE AccEisioN NO4 II T AAO UM811" 4. TITL[ (Wd SibItl@) ... . I YPE or REPORT I PERIOD COVERED...instructions for Fuel Cell Module FS-2. The ion exchange membrane fuel cell module is produced by the General Electric Company, Direct Energy

Measurements of Refractory Black Carbon (rBC) Aerosols in the McMurdo Dry Valleys, Antarctica

NASA Astrophysics Data System (ADS)

Khan, A. L.; McMeeking, G. R.; Lyons, W. B.; Schwarz, J. P.; Welch, K. A.; McKnight, D. M.

2015-12-01

Measurements of light absorbing particles in the boundary layer of the high southern latitudes are scarce. During the 2013-2014 austral summer field season refractory black carbon (rBC) aerosols were quantified by a single particle soot photometer (SP2) in the McMurdo Dry Valleys, Antarctica. The dark rBC particles absorb more radiation thereby increasing atmospheric heating, as well as reducing surface albedo and enhancing hydrologic melt when deposited on highly reflective surfaces such as snow and ice. Quantifying both local and long-range atmospheric transport of rBC to this region of a remote continent mostly covered by ice and snow would be useful in understanding meltwater generation as climate changes. Although the Dry Valleys are the largest ice-free region of Antarctica, they contain many alpine glaciers, some of which are fed from the East Antarctic Ice Sheet (EAIS). Continuous rBC measurements were collected at Lake Hoare Camp in the Taylor Valley for two months, along with shorter periods at more remote locations within the Dry Valleys. Conditions at the Lake Hoare Camp were dominated by up-valley winds from McMurdo Sound, however, winds also brought air down-valley from the EAIS polar plateau. Here we investigated periods dominated by both up and down-valley winds to explore differences in rBC concentrations, size distributions, and scattering properties. The average background rBC mass concentration was 1ng/m3, though concentrations as high as 50 ng/m3 were observed at times, likely due to local sources.

Theories of High Latitude Ionospheric Irregularities: A Review.

DTIC Science & Technology

1982-11-17

i or e) is the species density and E ic the total electric field. Since we will be interested in low frequencies and long wavelenghts , we have...5) by separating n - n (y) + 6n with 6n, 6+ a exp [i(kx + kz - wt)], w + iy, L (1/n )(an o/y). This gives a growth rate v . Vin cE0 B evd)] (6) 𔃼 in...34eai) + (kz2/k12 ))J]. (I denotes along z). The expression for the growth rate y in (6) can be maximized as a function of e - k /k , a measure of field

Integrated, flexible, and rapid geophysical surveying

NASA Astrophysics Data System (ADS)

Miller, S. F.; McGinnis, L. D.; Thompson, M. D.; Tome, C.

Aberdeen Proving Ground (APG) is currently managing a comprehensive Installation Restoration Program involving more than 360 solid-waste managing units contained within 13 study areas. The Edgewood area and two landfills in the Aberdeen area appear on the National Priority List under the Comprehensive Environmental Response, Compensation, and Liability Act. Therefore, APG has entered into an interagency agreement with the US Environmental Protection Agency to address the listed areas. The West Branch of the Canal Creek area, located within the Edgewood area, is one of the areas that requires a Source Definition Study because there is an ongoing release of volatile organic compounds into the creek. A report prepared in 1989 included a list of 29 potentially contaminated buildings in the Edgewood area. Sixteen of the buildings contain known contaminants, nine buildings contain unknown contaminants, and four of the buildings are potentially clean. The EAI report recommended that a sampling and monitoring program be established to verify contamination levels in and around each building. Thirteen of the potentially contaminated buildings are in the West Branch of the Canal Creek area and are potential sources of volatile organic compounds. Operations have ceased, and the buildings have been abandoned, but processing equipment, sumps, drains, ventilation systems, and underground storage tanks remain. These appurtenances may contain liquid, solid, or vapor contaminants of unknown nature.

Interhemispheric ice-sheet synchronicity during the Last Glacial Maximum

NASA Astrophysics Data System (ADS)

Weber, M. E.; Clark, P. U.; Ricken, W.; Mitrovica, J. X.; Hostetler, S. W.; Kuhn, G.

2012-04-01

The timing of the last maximum extent of the Antarctic ice sheets relative to those in the Northern Hemisphere remains poorly understood because only a few findings with robust chronologies exist for Antarctic ice sheets. We developed a chronology for the Weddell Sea sector of the East Antarctic ice sheet that, combined with ages from other Antarctic ice-sheet sectors, indicates the advance to their maximum extent at 29 -28 ka, and retreat from their maximum extent at 19 ka was nearly synchronous with Northern Hemisphere ice sheets (Weber, M.E., Clark, P. U., Ricken, W., Mitrovica, J. X., Hostetler, S. W., and Kuhn, G. (2011): Interhemispheric ice-sheet synchronicity during the Last Glacial Maximum. - Science, 334, 1265-1269, doi: 10.1126:science.1209299). As for the deglaciation, modeling studies suggest a late ice-sheet retreat starting around 14 ka BP and ending around 7 ka BP with a large impact of an unstable West Antarctic Ice Sheet (WAIS) and a small impact of a stable East Antarctic Ice Sheet (EAIS). However, the Weddell Sea sites studied here, as well as sites from the Scotia Sea, provide evidence that specifically the EAIS responded much earlier, possibly provided a significant contribution to the last sea-level rise, and was much more dynamic than previously thought. Using the results of an atmospheric general circulation we conclude that surface climate forcing of Antarctic ice mass balance would likely cause an opposite response, whereby a warming climate would increase accumulation but not surface melting. Furthermore, our new data support teleconnections involving a sea-level fingerprint forced from Northern Hemisphere ice sheets as indicated by gravitational modeling. Also, changes in North Atlantic Deepwater formation and attendant heat flux to Antarctic grounding lines may have contributed to synchronizing the hemispheric ice sheets.

Marine evidence of a deconvolving Antarctic Ice Sheet during post-LGM retreat of the Ross Sea sector

NASA Astrophysics Data System (ADS)

Prothro, L. O.; Yokoyama, Y.; Simkins, L. M.; Anderson, J. B.; Majewski, W.; Yamane, M.; Ohkouchi, N.

2017-12-01

Predictive models of ice sheet and sea level change are dependent on observational data of ice-sheet behavior for model testing and tuning. The geologic record contains a wealth of information about ice-sheet dynamics, with fewer logistical, spatial, and temporal limitations than are involved in data acquisition along contemporary ice margins. However, past ice-sheet behavior is still largely uncertain or contested due to issues with obtaining meaningful radiocarbon dates. We minimize bias from glacially-reworked carbon and limitations from unknown geomorphic context and uncertainty in sediment facies identification by using careful sedimentary analyses within a geomorphic framework, as well as selection of appropriate dating methods. Our study area, the Ross Sea sector of Antarctica, is the primary drainage outlet for 25% of the continent's grounded ice. During the Last Glacial Maximum, the low-profile, marine-based West Antarctic Ice Sheet (WAIS) and the steeper profile, largely land-based East Antarctic Ice Sheet (EAIS) converged in the Ross Sea to flow out to or near the continental shelf edge. Geomorphic and sedimentary data reveal that during their subsequent retreat to form the Ross Sea Embayment, the two ice sheets behaved differently, with the WAIS rapidly retreating tens of kilometers followed by extended pauses, while the EAIS retreated steadily, with shorter (decadal- to century-long) pauses. This behavior leads us to believe that the two ice sheets may have contributed diachronously to sea level. By acquiring accurate timing of grounding line retreat, we are able to calculate volumes of ice lost throughout deglaciation, as well as associated sea level contributions. In addition, we attempt to rectify the contradicting marine and terrestrial interpretations of retreat patterns from the Ross Sea continental shelf.

Mycobacterium tuberculosis causing tuberculous lymphadenitis in Maputo, Mozambique.

PubMed

Viegas, Sofia Omar; Ghebremichael, Solomon; Massawo, Leguesse; Alberto, Matos; Fernandes, Fabíola Couto; Monteiro, Eliane; Couvin, David; Matavele, José Maiane; Rastogi, Nalin; Correia-Neves, Margarida; Machado, Adelina; Carrilho, Carla; Groenheit, Ramona; Källenius, Gunilla; Koivula, Tuija

2015-11-21

The zoonosis bovine tuberculosis (TB) is known to be responsible for a considerable proportion of extrapulmonary TB. In Mozambique, bovine TB is a recognised problem in cattle, but little has been done to evaluate how Mycobacterium bovis has contributed to human TB. We here explore the public health risk for bovine TB in Maputo, by characterizing the isolates from tuberculous lymphadenitis (TBLN) cases, a common manifestation of bovine TB in humans, in the Pathology Service of Maputo Central Hospital, in Mozambique, during one year. Among 110 patients suspected of having TBLN, 49 had a positive culture result. Of those, 48 (98%) were positive for Mycobacterium tuberculosis complex and one for nontuberculous mycobacteria. Of the 45 isolates analysed by spoligotyping and Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeat (MIRU-VNTR), all were M. tuberculosis. No M. bovis was found. Cervical TBLN, corresponding to 39 (86.7%) cases, was the main cause of TBLN and 66.7% of those where from HIV positive patients. We found that TBLN in Maputo was caused by a variety of M. tuberculosis strains. The most prevalent lineage was the EAI (n = 19; 43.2%). Particular common spoligotypes were SIT 48 (EAI1_SOM sublineage), SIT 42 (LAM 9), SIT 1 (Beijing) and SIT53 (T1), similar to findings among pulmonary cases. M. tuberculosis was the main etiological agent of TBLN in Maputo. M. tuberculosis genotypes were similar to the ones causing pulmonary TB, suggesting that in Maputo, cases of TBLN arise from the same source as pulmonary TB, rather than from an external zoonotic source. Further research is needed on other forms of extrapulmonary TB and in rural areas where there is high prevalence of bovine TB in cattle, to evaluate the risk of transmission of M. bovis from cattle to humans.

The use of supplements and performance and image enhancing drugs in fitness settings: A exploratory cross-sectional investigation in the United Kingdom.

PubMed

Mooney, Roisin; Simonato, Pierluigi; Ruparelia, Risha; Roman-Urrestarazu, Andres; Martinotti, Giovanni; Corazza, Ornella

2017-05-01

The strive for perfection is prevalent in the fitness industry. This study aimed to explore the use of products to enhance performance alongside exposure to exercise addiction, appearance anxiety and self-esteem in fitness settings. An online survey was prepared and piloted before wider dissemination in fitness clubs via snowballing and selected mailing lists. A list of commonly used products, including Performance and Image Enhancing Drugs (PIEDs) was provided. Exercise addiction (Exercise Addiction Inventory; EAI), anxiety levels (Appearance Anxiety Inventory; AAI) and their self-esteem (Rosenberg's Self-Esteem Scale; RSE) were also measured. 377 questionnaires were completed. A significant number of participants declared the use products either to lose weight (16%) or to reach their fitness goals (41%). The Internet played a major role in both the supply of information and the provision of the enhancement products (33.7%) and side effects were reported (10.5%). Only a limited number of participants sought a medical opinion about taking products (5.1%). EAI scores were high (m=20.02 ± 4.1), AAI (m=15.98 ± 4.8) showed an intermediate level of anxiety, while self-esteem was low (RSE m=12.59 ± 2.2). This pilot study identified the emergence of a new drug trend in fitness settings and showed a potential relationship to exercise addiction, anxiety disorders and low self-esteem. The Internet played a crucial role in disseminating often untested products, including PIEDs without medical supervision and unwanted side-effects were reported. More studies in the field are required in order to safeguard public health and inform policy making. Copyright © 2017 John Wiley & Sons, Ltd.

Repeated large-scale retreat and advance of Totten Glacier indicated by inland bed erosion.

PubMed

Aitken, A R A; Roberts, J L; van Ommen, T D; Young, D A; Golledge, N R; Greenbaum, J S; Blankenship, D D; Siegert, M J

2016-05-19

Climate variations cause ice sheets to retreat and advance, raising or lowering sea level by metres to decametres. The basic relationship is unambiguous, but the timing, magnitude and sources of sea-level change remain unclear; in particular, the contribution of the East Antarctic Ice Sheet (EAIS) is ill defined, restricting our appreciation of potential future change. Several lines of evidence suggest possible collapse of the Totten Glacier into interior basins during past warm periods, most notably the Pliocene epoch, causing several metres of sea-level rise. However, the structure and long-term evolution of the ice sheet in this region have been understood insufficiently to constrain past ice-sheet extents. Here we show that deep ice-sheet erosion-enough to expose basement rocks-has occurred in two regions: the head of the Totten Glacier, within 150 kilometres of today's grounding line; and deep within the Sabrina Subglacial Basin, 350-550 kilometres from this grounding line. Our results, based on ICECAP aerogeophysical data, demarcate the marginal zones of two distinct quasi-stable EAIS configurations, corresponding to the 'modern-scale' ice sheet (with a marginal zone near the present ice-sheet margin) and the retreated ice sheet (with the marginal zone located far inland). The transitional region of 200-250 kilometres in width is less eroded, suggesting shorter-lived exposure to eroding conditions during repeated retreat-advance events, which are probably driven by ocean-forced instabilities. Representative ice-sheet models indicate that the global sea-level increase resulting from retreat in this sector can be up to 0.9 metres in the modern-scale configuration, and exceeds 2 metres in the retreated configuration.

Assessment of heavy metal pollution risks and enzyme activity of meadow soils in urban area under tourism load: a case study from Zakopane (Poland).

PubMed

Ciarkowska, Krystyna

2018-05-01

Effect of tourism, especially skiing activities, and urbanization on chemical and biochemical properties of soils in touristy town-Zakopane-was investigated. The concentration of heavy metals, nutrients, soil organic matter (SOM), dehydrogenase (DHA), invertase (IA) and urease (Ure) activities in soils from the town centre and out of the town centre was compared with the respective values of adjacent soils in protected areas (TNP). In order to evaluate a degree of contamination and risks of degradation enrichment factor (EF), ecological risk index (RI), Nemerov Pollution Index (PI Nemerov ) as well as enzyme activity index (EAI) were calculated. Soils in the centre of Zakopane were polluted with Zn, Pb, Cd and Cu in a moderate degree when those of skiing areas were polluted with Pb and Cd in a high degree. Strong positive correlation between these metals and negative correlation between them and a distance from the main roundabout in town indicated their anthropogenic origin. Soils of both locations were also enriched in P, but depleted in SOM when compared to TNP soils. Soils of touristy areas (out of the centre) were additionally enriched in N. Activity of studied enzymes was also lowered in soils of Zakopane when compared to soils of TNP. Pollution indices, RI, PI Nemerov as well as EAI, indicated that soils of Zakopane are at risk of degradation. Soils of touristy areas are under stronger negative impact than soils of the centre because of the cumulative effect of transport of heavy metals from the city centre, pollution by skiing machinery and melting water from the artificial snow.

Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions

PubMed Central

Zhang, Guijuan; Ma, Yi; Fan, Hongxia

2017-01-01

Ruyan Neixiao Cream (RYNXC) is a traditional Chinese herbal formula for treating mammary precancerous disease. This study was carried out to investigate in vivo anticancer effect of RYNXC and multiple constituents. 32 virginal Sprague-Dawley rats were randomly divided into blank control group (BC), mammary precancer models group (MODEL), tamoxifen group (TAM), and Ruyan Neixiao Cream group (RYNXC). TAM was intervened by tamoxifen; RYNXC was intervened by Ruyan Neixiao Cream. The chromatographic separation was performed by high performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). RYNXC showed significant improvement in erythrocyte aggregation index (EAI), hematocrit (HCT), fibrinogen (FIB), spleen coefficient, and uterus coefficient compared with MODEL. In RYNXC and TAM groups, atypical hyperplasia was observed in pathological mammary tissues; meanwhile in MODEL group, ductal carcinoma was observed in situ. Moreover, fifteen compounds were characterized according to HPLC-MS data, including organic acids, tannin, alkaloid, volatile oil, anthraquinones, and flavonoids. The study suggests that RYNXC was an effective Chinese herbal formula for mammary precancerous lesions and provides a scientific basis for the quality standard and the pharmacology of RYNXC. It will be beneficial to the future clinical application of RYNXC. PMID:28811827

Installation Restoration Program. Phase 1 - Records Search, Travis AFB, California

DTIC Science & Technology

1983-08-01

Personnel Transportation Assistance Office Navy Construction Office (ROICC) Navy Quick Trans CPE Cargo OL-K AFESC/CEMRT OL OH AF Commissary/ FCS Operating Loc...du u U C AS I- z I- < L z Z ’CIA F,.- **z z - C -o -C Z. -2 X.,~a S.. ’ l - x CO I II I EAI IIV I - -. I t1 -1 z In-’S I LA- 0..u 2gU, 0 z u Fc -jIL...used at the site comprised, AFFF , protein foam and water. The site has no berms or dikes to contain the runoff. Surface runoff from the site has to

Constraining East Antarctic mass trends using a Bayesian inference approach

NASA Astrophysics Data System (ADS)

Martin-Español, Alba; Bamber, Jonathan L.

2016-04-01

East Antarctica is an order of magnitude larger than its western neighbour and the Greenland ice sheet. It has the greatest potential to contribute to sea level rise of any source, including non-glacial contributors. It is, however, the most challenging ice mass to constrain because of a range of factors including the relative paucity of in-situ observations and the poor signal to noise ratio of Earth Observation data such as satellite altimetry and gravimetry. A recent study using satellite radar and laser altimetry (Zwally et al. 2015) concluded that the East Antarctic Ice Sheet (EAIS) had been accumulating mass at a rate of 136±28 Gt/yr for the period 2003-08. Here, we use a Bayesian hierarchical model, which has been tested on, and applied to, the whole of Antarctica, to investigate the impact of different assumptions regarding the origin of elevation changes of the EAIS. We combined GRACE, satellite laser and radar altimeter data and GPS measurements to solve simultaneously for surface processes (primarily surface mass balance, SMB), ice dynamics and glacio-isostatic adjustment over the period 2003-13. The hierarchical model partitions mass trends between SMB and ice dynamics based on physical principles and measures of statistical likelihood. Without imposing the division between these processes, the model apportions about a third of the mass trend to ice dynamics, +18 Gt/yr, and two thirds, +39 Gt/yr, to SMB. The total mass trend for that period for the EAIS was 57±20 Gt/yr. Over the period 2003-08, we obtain an ice dynamic trend of 12 Gt/yr and a SMB trend of 15 Gt/yr, with a total mass trend of 27 Gt/yr. We then imposed the condition that the surface mass balance is tightly constrained by the regional climate model RACMO2.3 and allowed height changes due to ice dynamics to occur in areas of low surface velocities (<10 m/yr) , such as those in the interior of East Antarctica (a similar condition as used in Zwally 2015). The model must find a solution that satisfies all the input data, given these constraints. By imposing these conditions, over the period 2003-13 we obtained a mass gain due to ice dynamics of 103±15 Gt/yr but this was offset by a negative trend in SMB of 47 Gt/yr, resulting in an overall positive trend of 56±15 Gt/yr. Over 2003-08, the ice dynamics trend is 96 Gt/yr, offset by a strong negative SMB trend of -81 Gt/yr, with a total mass trend of 15±13Gt/yr. Even after relaxing the ice dynamics constraint over East Antarctica, we are unable to reproduce the large positive trend obtained in Zwally2015. We conclude that this result is inconsistent with the combined observations, irrespective of any assumption made about the density of surface elevation changes.

Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei.

PubMed

Dou, Horng-Yunn; Tseng, Fan-Chen; Lin, Chih-Wei; Chang, Jia-Ru; Sun, Jun-Ren; Tsai, Wen-Shing; Lee, Shi-Yi; Su, Ih-Jen; Lu, Jang-Jih

2008-12-22

The control of tuberculosis in densely populated cities is complicated by close human-to-human contacts and potential transmission of pathogens from multiple sources. We conducted a molecular epidemiologic analysis of 356 Mycobacterium tuberculosis (MTB) isolates from patients presenting pulmonary tuberculosis in metropolitan Taipei. Classical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and spoligotyping, were applied after culture. A total of 356 isolates were genotyped by standard spoligotyping and the strains were compared with in the international spoligotyping database (SpolDB4). All isolates were also categorized using the 15 loci MIRU-VNTR typing method and combin with NTF locus and RD deletion analyses. Of 356 isolates spoligotyped, 290 (81.4%) displayed known spoligotypes and 66 were not identified in the database. Major spoligotypes found were Beijing lineages (52.5%), followed by Haarlem lineages (13.5%) and EAI plus EAI-like lineages (11%). When MIRU-VNTR was employed, 140 patterns were identified, including 36 clusters by 252 isolates and 104 unique patterns, and the largest cluster comprised 95 isolates from the Beijing family. The combination of spoligotyping and MIRU-VNTR revealed that 236 (67%) of the 356 isolates were clustered in 43 genotypes. Strains of the Beijing family was more likely to be of modern strain and a higher percentage of multiple drug resistance than other families combined (P = 0.08). Patients infected with Beijing strains were younger than those with other strains (mean 58.7 vs. 64.2, p = 0.02). Moreover, 85.3% of infected persons younger than 25 years had Beijing modern strain, suggesting a possible recent spread in the young population by this family of TB strain in Taipei. Our data on MTB genotype in Taipei suggest that MTB infection has not been optimally controlled. Control efforts should be reinforced in view of the high prevalence of the Beijing strain in young population and association with drug resistance.

Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei

PubMed Central

Dou, Horng-Yunn; Tseng, Fan-Chen; Lin, Chih-Wei; Chang, Jia-Ru; Sun, Jun-Ren; Tsai, Wen-Shing; Lee, Shi-Yi; Su, Ih-Jen; Lu, Jang-Jih

2008-01-01

Background The control of tuberculosis in densely populated cities is complicated by close human-to-human contacts and potential transmission of pathogens from multiple sources. We conducted a molecular epidemiologic analysis of 356 Mycobacterium tuberculosis (MTB) isolates from patients presenting pulmonary tuberculosis in metropolitan Taipei. Classical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and spoligotyping, were applied after culture. Methods A total of 356 isolates were genotyped by standard spoligotyping and the strains were compared with in the international spoligotyping database (SpolDB4). All isolates were also categorized using the 15 loci MIRU-VNTR typing method and combin with NTF locus and RD deletion analyses. Results Of 356 isolates spoligotyped, 290 (81.4%) displayed known spoligotypes and 66 were not identified in the database. Major spoligotypes found were Beijing lineages (52.5%), followed by Haarlem lineages (13.5%) and EAI plus EAI-like lineages (11%). When MIRU-VNTR was employed, 140 patterns were identified, including 36 clusters by 252 isolates and 104 unique patterns, and the largest cluster comprised 95 isolates from the Beijing family. The combination of spoligotyping and MIRU-VNTR revealed that 236 (67%) of the 356 isolates were clustered in 43 genotypes. Strains of the Beijing family was more likely to be of modern strain and a higher percentage of multiple drug resistance than other families combined (P = 0.08). Patients infected with Beijing strains were younger than those with other strains (mean 58.7 vs. 64.2, p = 0.02). Moreover, 85.3% of infected persons younger than 25 years had Beijing modern strain, suggesting a possible recent spread in the young population by this family of TB strain in Taipei. Conclusion Our data on MTB genotype in Taipei suggest that MTB infection has not been optimally controlled. Control efforts should be reinforced in view of the high prevalence of the Beijing strain in young population and association with drug resistance. PMID:19102768

Diffusion-weighted imaging for evaluating inflammatory activity in Crohn's disease: comparison with histopathology, conventional MRI activity scores, and faecal calprotectin.

PubMed

Pendsé, D A; Makanyanga, J C; Plumb, A A; Bhatnagar, G; Atkinson, D; Rodriguez-Justo, Manuel; Halligan, S; Taylor, S A

2017-01-01

To evaluate whether the extent of enteric diffusion-weighted imaging (DWI) signal abnormality reflects inflammatory burden in Crohn's disease (CD), and to compare qualitative and quantitative grading. 69 CD patients (35 male, age 16-78) undergoing MR enterography with DWI (MRE-D) and the same-day faecal calprotectin (cohort 1) were supplemented by 29 patients (19 male, age 16-70) undergoing MRE-D and terminal ileal biopsy (cohort 2). Global (cohort 1) and terminal ileal (cohort 2) DWI signal was graded (0 to 3) by 2 radiologists and segmental apparent diffusion coefficient (ADC) calculated. Data were compared to calprotectin and a validated MRI activity score [MEGS] (cohort 1), and a histopathological activity score (eAIS) (cohort 2) using nonparametric testing and rank correlation. Patients with normal (grades 0 and 1) DWI signal had lower calprotectin and MEGS than those with abnormal signal (grades 2 and 3) (160 vs. 492 μg/l, p = 0.0004, and 3.3 vs. 21, p < 0.0001), respectively. Calprotectin was lower if abnormal DWI affected <10 cm of small bowel compared to diffuse small and large bowel abnormality (236 vs. 571 μg, p = 0.009). The sensitivity and specificity for active disease (calprotectin > 120 μg/l) were 83% and 52%, respectively. There was a negative correlation between ileal MEGS and ADC (r = -0.41, p = 0.017). There was no significant difference in eAIS between qualitative DWI scores (p = 0.42). Mean ADC was not different in those with and without histological inflammation (2077 vs. 1622 × 10 -6 mm 2 /s, p = 0.10) CONCLUSIONS: Qualitative grading of DWI signal has utility in defining the burden of CD activity. Quantitative ADC measurements have poor discriminatory ability for segmental disease activity.

China's first intermediate resolution multi-channel seismic survey in the northern Victoria Land Basin and Terror Rift, Ross Sea, Antarctica

NASA Astrophysics Data System (ADS)

Shen, Zhongyan; Gao, Jinyao; Zhang, Tao; Wang, Wei; Ding, Weifeng; Zhang, Sheng

2017-04-01

The West Antarctic Rift System (WARS) represents one of the largest active continental rift systems on Earth and is less well known than other rift systems because it is largely covered by thick ice. The Terror Rift (TR), superimposing on the Victoria Land Basin (VLB) in the western Ross Sea, is identified as the most recent deformational zone of the WARS, thus will provide knowledge of the active deformation process of the WARS. The structure and kinematics of the TR is under debate. Originally, the TR was thought to consist of two parts: the Discovery Graben and the magmatically-intruded Lee Arch. New denser seismic grid in the middle and southern segments of the TR revealed a different structure of the Lee Arch while the northern segment of the TR is not well studied. The glacial history of the VLB/TR region is another attractive issue to the geologists since this area records the behavior information of EAIS and WAIS. In the southern part of the VLB, especially in the McMurdo Sound, the framework of the glacial history is well established after several deep cores which recovery the whole stratigraphic sequences since the onset of the glaciation. However, the glacial history of the northern part of the VLB/TR is less well studied and here we emphasize its importance because the northern part of the VLB/TR is a link between the well-studied southern VLB and the sediment-well-preserved Northern Basin. During the 32nd Chinese National Antarctic Research Expedition, on the board of the RV XueLong, we collected intermediate resolution multi-channel seismic reflection data in the northern VLB/TR. These data will establish new constraints on the timing of deformation, structure and kinematics of the TR, and the history of the EAIS and WAIS.

Influence of the West Antarctic Ice Sheet and its collapse on the wind and precipitation regimes of the Ross Embayment

NASA Astrophysics Data System (ADS)

Seles, D.; Kowalewski, D. E.

2015-12-01

Marine Isotope Stage 31 (MIS 31) is a key analogue for current warming trends yet the extent of the East Antarctic Ice Sheet (EAIS) and the West Antarctic Ice Sheet (WAIS) during this interglacial remains unresolved. Inconsistencies persist between offshore records (suggesting the instability of WAIS) and McMurdo Dry Valley (MDV) terrestrial datasets (indicating long-term ice sheet stability). Here we use a high-resolution regional scale climate model (RegCM3_Polar) to reconstruct paleoclimate during MIS 31 (warm orbit, 400 ppm CO2) and assess changes in precipitation and winds (including katabatic) with WAIS present versus WAIS absent. The MIS 31 scenario with WAIS present resulted in minimal changes in wind magnitude compared with current climate conditions. With WAIS absent, the model predicts a decrease in coastal and highland monthly mean average wind velocities. The greatest rates of snowfall remain along the coast but shift towards higher latitudes with the interior continent remaining dry when WAIS is removed. Focusing on the Ross Embayment, this decreased monthly mean wind velocity and shift of winds to the east indicate a greater influence of offshore winds from the Ross Sea, enabling the increase of precipitation southward along the Transantarctic Mountains (TAM) (i.e. MDV). The apparent decrease of katabatic winds with no WAIS implies that offshore winds may be responsible for bringing the warmer, wetter air into the TAM. The change in wind and precipitation in the Ross Embayment and specifically the MDV highlights the impact of WAIS on Antarctic climate and its subsequent influence on the mass balance of peripheral EAIS domes (i.e. Taylor Dome). Modeling suggests that if WAIS was absent during MIS 31, we would expect (1) greater accumulation at such domes and (2) MDV terrestrial records that reflect a wetter climate, and (3) weaker winds suggesting possibly lower ablation/erosion rates compared to if WAIS was present.

First Insight into the Population Structure of Mycobacterium tuberculosis in Saudi Arabia▿ †

PubMed Central

Al-Hajoj, Sahal A. M.; Zozio, Thierry; Al-Rabiah, Fahad; Mohammad, Viquar; Al-Nasser, Maryam; Sola, Christophe; Rastogi, Nalin

2007-01-01

This study constitutes a first attempt to describe the genetic population structure and drug resistance of the tubercle bacilli circulating in Saudi Arabia. A total of 1,505 clinical isolates of M. tuberculosis, isolated between 2002 and 2005 from seven regions of Saudi Arabia, were studied. The sample studied showed a male-to-female sex ratio of 1.27, with half of the cases among foreign-born individuals and 47% within the 21- to 40-year-old age group; a total resistance rate of 19.7%; and multiple drug resistance of 4.5%. Upon spoligotyping, a total of 387 individual patterns were obtained (clustering rate, 86.4%; 182 clusters containing between 2 and 130 isolates per cluster). A total of 94% of the strains matched the spoligotype patterns in an international database. Nearly 81% of the isolates in this study belonged to established phylogeographic clades: Central Asian (CAS), 22.5%; ill-defined T clade, 19.5%; East African-Indian (EAI), 13.5%; Haarlem, 7.5%; Latin American-Mediterranean, 7.2%; Beijing, 4.4%; Manu, 2.7%; X, 0.9%; and Bovis, 0.9%. Two clonal complexes with unique spoligotyping signatures (octal codes 703777707770371 and 467777377413771) specific to Saudi Arabia were identified. These belonged to the CAS and EAI clades, respectively, as confirmed upon secondary typing using mycobacterial interspersed repetitive units (MIRUs). The results obtained underline the predominance of historic clones of principal genetic group 1, which are responsible for roughly 45% of all tuberculosis cases in Saudi Arabia. The high rate of clustering observed might be an indication of rapid ongoing transmission within certain communities and/or subpopulations in Saudi Arabia; nonetheless, spoligotyping is known to overestimate clustering, and only a systematic second-line typing, such as MIRUs, coupled with a better tuberculosis registry and epidemiological investigations would allow us to know the exact rate of ongoing transmission and associated risk factors in Saudi Arabia. PMID:17507515

Tuberculosis Transmission among Immigrants and Autochthonous Populations of the Eastern Province of Saudi Arabia

PubMed Central

Varghese, Bright; Supply, Philip; Shoukri, Mohammed; Allix-Beguec, Caroline; Memish, Ziad; Abuljadayel, Naila; Al-Hakeem, Raafat; AlRabiah, Fahad; Al-Hajoj, Sahal

2013-01-01

Background Eastern province of Saudi Arabia is an industrial zone with large immigrant population and high level of tuberculosis case notification among immigrants. The impact of immigration and current trends of tuberculosis transmission among immigrants and autochthonous population in the region had not been investigated so far using molecular tools. Methodology During 2009- 2011, a total of 524 Mycobacterium tuberculosis isolates were collected from the central tuberculosis reference laboratory, representing an estimated 79.2% of the culture-positive tuberculosis cases over the study period in the province. These isolates were genotyped by using 24 locus-based MIRU-VNTR typing and spoligotyping followed by first line drug susceptibility testing. The molecular clustering profiles and phylogenetic diversity of isolates were determined and compared to the geographical origins of the patients. Principle Findings Genotyping showed an overall predominance of Delhi/CAS (29.4%), EAI (23.8%) and Ghana (13.3%) lineages, with slightly higher proportions of Delhi/CAS among autochthonous population (33.3 %) and EAI (30.9%) among immigrants. Rate of any drug resistance was 20.2% with 2.5% of multi-drug resistance. Strain cluster analysis indicated 42 clusters comprising 210 isolates, resulting in a calculated recent transmission index of 32.1%. Overall shared cluster ratio was 78.6% while 75.8% were shared between autochthonous population and immigrant population with a predominance of immigrants from South east Asia (40.7%). In contrast, cross national transmission within the immigrant population was limited (24.2%). Younger age (15-30- p value-0.043, 16-45, p value 0.030), Saudi nationality (p value-0.004) and South East Asian origin (p value-0.011) were identified as significant predisposing factors for molecular strain clustering. Conclusions The high proportion of molecular clusters shared among the autochthonous and immigrant populations suggests a high permeability of tuberculosis transmission between both populations in the province. These results prompt for the need to strengthen the current tuberculosis control strategies and surveillance programs. PMID:24147042

Prevalence and triggers of anaphylactic events in schools.

PubMed

White, Martha V; Silvia, Suyapa; Muniz, Rafael; Herrem, Christopher; Hogue, Susan L

2017-07-01

Prevention and management of anaphylaxis in schools is an area of active interest as allergy and asthma rates in children continue to increase. A greater understanding of the prevalence and characteristics of anaphylaxis can help guide preventive and management strategies both within and outside of the school setting, with the goal of reducing morbidity and mortality. This study was performed to elucidate the epidemiology of and management strategies for anaphylaxis in the school setting. A cross-sectional, Web-based survey was administered to schools that participated in an initiative that provides stock epinephrine autoinjectors (EAIs) to qualifying U.S. schools. Representatives from participating schools completed a questionnaire regarding anaphylactic reactions that occurred during the 2014-2015 school year. Weighted analyses were performed to account for differential responses between schools that completed the survey and those that did not. A total of 12,275 of the 45,819 invited schools responded to the survey. The occurrence of one or more anaphylactic events was reported by 1358 schools. Most events (89.8% [1803/2008]) occurred in students. High school students accounted for the largest proportion of anaphylactic reactions among students (40.1% [723/1802]). Food was the most commonly identified anaphylaxis trigger across grade levels, seasons, and geographic regions. The trigger was unknown to the individual who experienced anaphylaxis in 21.8% of the events (436/1998). No known history of allergy or asthma was present in 24.5% (491/2001) and 51.3% (1026/2000) of affected individuals, respectively. Transportation to the hospital or clinic for further treatment and/or management was reported for 72.6% of the individuals with anaphylactic events (1450/1997). Results from the weighted analyses were similar to those of the unweighted analyses. Anaphylaxis occurred across grade levels and in individuals with or without known risk factors, which reinforced the need for school preparedness in both management of anaphylaxis and stocking of EAIs.

BABOC: A new project aimed at analysing geological boundary conditions for the East Antarctic Ice Sheet in the Wilkes Subglacial Basin

NASA Astrophysics Data System (ADS)

Armadillo, Egidio; Ferraccioli, Fausto; Balbi, Pietro; Jordan, Tom; Young, Duncan; Blankenship, Don; Bozzo, Emanuele; Siegert, Martin

2013-04-01

The Wilkes Subglacial Basin extends for ca 1,400 km from George V Land into the interior of East Antarctica and hosts several major glaciers that drain a large sector of the East Antarctic Ice Sheet (EAIS). The region is of major significance for assessing the long-term stability of the EAIS, as it lies well below sea level and its bedrock deepens inland. This makes it potentially prone to marine ice sheet instability, much like areas of the West Antarctic Ice Sheet (WAIS) that are presently experiencing significant mass loss. This sector of the EAIS has also recently become a major focus of research within IODP Leg 318 that aims to better comprehend the initial stages of glaciation in East Antarctica and the subsequent history and stability of the ice sheet in response to major paleoclimatic changes (Escutia et al., 2010 IODP Rep.). Understanding geological boundary conditions in this region is therefore important to assess their influence on ice sheet dynamics and stability. Early geophysical models inferred the existence of a major extensional sedimentary basin beneath the region, which if true, could be similar to some areas of the WAIS, There thick subglacial sediments deposited within deep rift basins or forming thin marine sedimentary drapes have been inferred to exert a key influence on the onset and maintenance of fast-glacial flow. However, later geophysical models indicated that the Wilkes Basin contains little or no sediment, is not rift-related and formed in response to Cenozoic flexural uplift of the Transantarctic Mountains (TAM). A major joint Italian-UK aerogeophysical exploration campaign over parts of the Wilkes Basin is super-seeding these earlier geophysical views of the basin: i) Precambrian and Paleozoic basement faults can now be recognised as exerting fundamental controls on the location of the topographic margins of the basin; ii) the crust underlying the basin is thinner compared to the TAM, but is unlikely to be Cretaceous or Cenozoic-age rifted crust and; iii) its bedrock is composed of a variety of rocks of different ages and bulk composition, including inferred Proterozoic basement, Neoproterozoic and Cambrian sediments intruded by Cambrian arc rocks, and cover rocks formed primarily by Beacon sediments intruded by Ferrar sills of Jurassic age. Within the framework of the collaborative Italian-US-UK BABOC project a new initiative has been launched to analyse and model variable geological boundary conditions in the Wilkes Basin, by analysing both new and existing geophysical data. A couple of new flights over the region were flown by the ICECAP team for BABOC during the 2010-11 field campaign from Mario Zucchelli Station. ICECAP independently acquired a suite of extensive aerogeophysical observations over three campaigns, centred in particular over the southern part of the basin, and some new profiles over the northern coastal margin of the basin. We present an initial analyses and interpretation of the potential field signatures over the different parts of the basin and assess regional geological controls on the subglacial topography of the basin.

Effect of pulsed ultrasound on the physicochemical characteristics and emulsifying properties of squid (Dosidicus gigas) mantle proteins.

PubMed

Higuera-Barraza, O A; Torres-Arreola, W; Ezquerra-Brauer, J M; Cinco-Moroyoqui, F J; Rodríguez Figueroa, J C; Marquez-Ríos, E

2017-09-01

Food technologists are always looking to improve the functional properties of proteins. In this sense, in last years ultrasound has been used to improve some functional properties. For this reason, and considering that jumbo squid is an important fishery in northwest Mexico, the purpose of this research was to determine the effect of pulsed ultrasound on the physicochemical characteristics and emulsifying properties of squid (Dosidicus gigas) mantle proteins. Pulsed ultrasound (20kHz, 20, and 40% amplitude) was applied for 30, 60, and 90s to a protein extract prepared from giant squid mantle causing an increase (p<0.05) in surface hydrophobicity (S o ) from 108.4±1.4 to 239.1±2.4 after application of pulsed ultrasound at 40% of amplitude for 90s. The electrophoretic profile and the total and reactive sulfhydryl contents were not affected (p⩾0.05) by the ultrasound treatment. The emulsifying ability of the protein solution was improved (p<0.05), whereas the Emulsifier Activity Index (EAI) varied from123.67±5.52m 2 /g for the control and increased up to 217.7±3.8m 2 /g after application of the ultrasound. The Stability Emulsifier Index (EEI) was improved at 40% of amplitude by 60 and 90s. The results suggested that pulsed ultrasound used as pretreatment induced conformational changes in giant squid proteins, which improved the interfacial association between protein-oil phases, thus contributing to the improvement of their emulsifient properties. Copyright © 2017 Elsevier B.V. All rights reserved.

Comparative Study on Compositions and Functional Properties of Porcine, Chicken and Duck Blood

PubMed Central

2017-01-01

Hematological, chemical and functional characteristics of porcine, chicken and duck blood were evaluated. A porcine blood sample showed the most abundant red blood cell, hemoglobin concentration, packed cell volume and plasma protein content as well as its freeze-dried blood possessed the highest contents of protein, fat, Cu and Cr with the highest percentage of heme iron (p<0.05). Unlike porcine blood, chicken blood showed a well balance in some essential amino acids, specifically for a higher isoleucine content (p<0.05). Furthermore, it possessed the highest contents of carbohydrate, Zn and non-heme iron (p<0.05). The most rapid response to form a strong gel, especially at 70°C and 80°C, was found in chicken blood, followed by duck and porcine blood, respectively. The result of emulsion activity index (EAI) and emulsion stability index (ESI) at the low protein concentration indicated that chicken blood had the most superior emulsion properties (p<0.05). Regarding duck blood, it exhibited the highest content of Mg and Mn (p<0.05). Moreover, duck blood had similar foaming properties to porcine blood in which they showed higher values than chicken blood (p<0.05). Specific characteristics of blood were therefore diminished by animal species in which this information could be used as food supplementation or product development based on their potential applications. PMID:28515647

The Genotypic Population Structure of Mycobacterium tuberculosis Complex from Moroccan Patients Reveals a Predominance of Euro-American Lineages

PubMed Central

Lahlou, Ouafae; Millet, Julie; Chaoui, Imane; Sabouni, Radia; Filali-Maltouf, Abdelkarim; Akrim, Mohammed; El Mzibri, Mohammed; Rastogi, Nalin; El Aouad, Rajae

2012-01-01

Background Tuberculosis (TB) remains a major health problem in Morocco. Characterization of circulating Mycobacterium tuberculosis genotypic lineages, important to understand the dynamic of the disease, was hereby addressed for the first time at a national level. Methodology/Principal Findings Spoligotyping was performed on a panel of 592 M. tuberculosis complex strains covering a 2-year period (2004–2006). It identified 129 patterns: 105 (n = 568 strains) corresponded to a SIT number in the SITVIT2 database, while 24 patterns were labeled as orphan. A total of 523 (88.3%) strains were clustered vs. 69 or 11.7% unclustered. Classification of strains within 3 large phylogenetical groups was as follows: group 1– ancestral/TbD1+/PGG1 (EAI, Bovis, Africanum), group 2– modern/TbD1−/PGG1 group (Beijing, CAS), group 3– evolutionary recent/TbD1−/PGG2/3 (Haarlem, X, S, T, LAM; alternatively designated as the Euro-American lineage). As opposed to group 3 strains (namely LAM, Haarlem, and T) that predominated (86.5% of all isolates), 6 strains belonged to group 2 (Beijing n = 5, CAS n = 1), and 3 strains (BOV_1 n = 2, BOV_4-CAPRAE) belonged to ancestral group 1 (EAI and AFRI lineage strains were absent). 12-loci MIRU-VNTR typing of the Casablanca subgroup (n = 114 strains) identified 71 patterns: 48 MITs and 23 orphan patterns; it allowed to reduce the clustering rate from 72.8% to 29.8% and the recent transmission rate from 64% to 20.2%. Conclusion The M. tuberculosis population structure in Morocco is highly homogeneous, and is characterized by the predominance of the Euro-American lineages, namely LAM, Haarlem, and T, which belong to the “evolutionary recent” TbD1−/PGG2/3 phylogenetic group. The combination of spoligotyping and MIRUs decreased the clustering rate significantly, and should now be systematically applied in larger studies. The methods used in this study appear well suited to monitor the M. tuberculosis population structure for an enhanced TB management program in Morocco. PMID:23077552

Use of Human Modeling Simulation Software in the Task Analysis of the Environmental Control and Life Support System Component Installation Procedures

NASA Technical Reports Server (NTRS)

Estes, Samantha; Parker, Nelson C. (Technical Monitor)

2001-01-01

Virtual reality and simulation applications are becoming widespread in human task analysis. These programs have many benefits for the Human Factors Engineering field. Not only do creating and using virtual environments for human engineering analyses save money and time, this approach also promotes user experimentation and provides increased quality of analyses. This paper explains the human engineering task analysis performed on the Environmental Control and Life Support System (ECLSS) space station rack and its Distillation Assembly (DA) subsystem using EAI's human modeling simulation software, Jack. When installed on the International Space Station (ISS), ECLSS will provide the life and environment support needed to adequately sustain crew life. The DA is an Orbital Replaceable Unit (ORU) that provides means of wastewater (primarily urine from flight crew and experimental animals) reclamation. Jack was used to create a model of the weightless environment of the ISS Node 3, where the ECLSS is housed. Computer aided drawings of the ECLSS rack and DA system were also brought into the environment. Anthropometric models of a 95th percentile male and 5th percentile female were used to examine the human interfaces encountered during various ECLSS and DA tasks. The results of the task analyses were used in suggesting modifications to hardware and crew task procedures to improve accessibility, conserve crew time, and add convenience for the crew. This paper will address some of those suggested modifications and the method of presenting final analyses for requirements verification.

HEATPLOT: a temperature distribution plotting program for heating

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elrod, D.C.; Turner, W.D.

1977-07-01

HEATPLOT is a temperature distribution plotting program that may be used with HEATING5, a generalized heat conduction code. HEATPLOT is capable of drawing temperature contours (isotherms), temperature-time profiles, and temperature-distance profiles from the current HEATING5 temperature distribution or from temperature changes relative to the initial temperature distribution. Contour plots may be made for two- or three-dimensional models. Temperature-time profiles and temperature-distance profiles may be made for one-, two-, and three-dimensional models. HEATPLOT is an IBM 360/370 computer code which uses the DISSPLA plotting package. Plots may be created on the CALCOMP pen-and-ink, and CALCOMP cathode ray tube (CRT), or themore » EAI pen-and-ink plotters. Printer plots may be produced or a compressed data set that may be routed to any of the available plotters may be made.« less

Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load

PubMed Central

Chantler, Paul D.; Melenovsky, Vojtech; Schulman, Steven P.; Gerstenblith, Gary; Becker, Lewis C.; Ferrucci, Luigi; Fleg, Jerome L.; Najjar, Samer S.

2012-01-01

Effective arterial elastance(EA) is a measure of the net arterial load imposed on the heart that integrates the effects of heart rate(HR), peripheral vascular resistance(PVR), and total arterial compliance(TAC) and is a modulator of cardiac performance. To what extent the change in EA during exercise impacts on cardiac performance and aerobic capacity is unknown. We examined EA and its relationship with cardiovascular performance in 352 healthy subjects. Subjects underwent rest and exercise gated scans to measure cardiac volumes and to derive EA[end-systolic pressure/stroke volume index(SV)], PVR[MAP/(SV*HR)], and TAC(SV/pulse pressure). EA varied with exercise intensity: the ΔEA between rest and peak exercise along with its determinants, differed among individuals and ranged from −44% to +149%, and was independent of age and sex. Individuals were separated into 3 groups based on their ΔEAI. Individuals with the largest increase in ΔEA(group 3;ΔEA≥0.98 mmHg.m2/ml) had the smallest reduction in PVR, the greatest reduction in TAC and a similar increase in HR vs. group 1(ΔEA<0.22 mmHg.m2/ml). Furthermore, group 3 had a reduction in end-diastolic volume, and a blunted increase in SV(80%), and cardiac output(27%), during exercise vs. group 1. Despite limitations in the Frank-Starling mechanism and cardiac function, peak aerobic capacity did not differ by group because arterial-venous oxygen difference was greater in group 3 vs. 1. Thus the change in arterial load during exercise has important effects on the Frank-Starling mechanism and cardiac performance but not on exercise capacity. These findings provide interesting insights into the dynamic cardiovascular alterations during exercise. PMID:22003052

Mycobacterium tuberculosis Complex Genotype Diversity and Drug Resistance Profiles in a Pediatric Population in Mexico

PubMed Central

Macías Parra, Mercedes; Kumate Rodríguez, Jesús; Arredondo García, José Luís; López-Vidal, Yolanda; Castañón-Arreola, Mauricio; Balandrano, Susana; Rastogi, Nalin; Gutiérrez Castrellón, Pedro

2011-01-01

The aim of this study was to determine the frequency of drug resistance and the clonality of genotype patterns in M. tuberculosis clinical isolates from pediatric patients in Mexico (n = 90 patients from 19 states; time period—January 2002 to December 2003). Pulmonary disease was the most frequent clinical manifestation (71%). Children with systemic tuberculosis (TB) were significantly younger compared to patients with localized TB infections (mean 7.7 ± 6.2 years versus 15 ± 3.4 years P = 0.001). Resistance to any anti-TB drug was detected in 24/90 (26.7%) of the isolates; 21/90 (23.3%) and 10/90 (11.1%) were resistant to Isoniazid and Rifampicin, respectively, and 10/90 (11.1%) strains were multidrug-resistant (MDR). Spoligotyping produced a total of 55 different patterns; 12/55 corresponded to clustered isolates (n = 47, clustering rate of 52.2%), and 43/55 to unclustered isolates (19 patterns were designated as orphan by the SITVIT2 database). Database comparison led to designation of 36 shared types (SITs); 32 SITs (n = 65 isolates) matched a preexisting shared type in SITVIT2, whereas 4 SITs (n = 6 isolates) were newly created. Lineage classification based on principal genetic groups (PGG) revealed that 10% of the strains belonged to PGG1 (Bovis and Manu lineages). Among PGG2/3 group, the most predominant clade was the Latin-American and Mediterranean (LAM) in 27.8% of isolates, followed by Haarlem and T lineages. The number of single drug-resistant (DR) and multidrug-resistant (MDR-TB) isolates in this study was similar to previously reported in studies from adult population with risk factors. No association between the spoligotype, age, region, or resistance pattern was observed. However, contrary to a study on M. tuberculosis spoligotyping in Acapulco city that characterized a single cluster of SIT19 corresponding to the EAI2-Manila lineage in 70 (26%) of patients, not a single SIT19 isolate was found in our pediatric patient population. Neither did we find any shared type belonging to the EAI family which represents ancestral PGG1 strains within the M. tuberculosis complex. We conclude that the population structure of pediatric TB in our setting is different from the one prevailing in adult TB patient population of Guerrero. PMID:22567263

Geology of the Wilkes Land Sub-basin and Stability of the East Antarctic Ice Sheet: Insights from rock magnetism at IODP Site U1361

NASA Astrophysics Data System (ADS)

Tauxe, L.; Sugisaki, S.; Jimenez-Espejo, F. J.; Cook, C. P.; van de Flierdt, T.; Iwai, M.; Escutia, C.

2014-12-01

IODP Expedition 318 drilled Site U1361 on the continental rise offshore of the Wilkes sub-glacial basin. The goal was to reconstruct the stability of the East Antarctic Ice Sheet (EAIS) during Neogene warm periods. Teasing out the paleoenvironmental implications is essential for understanding the evolution of the EAIS. Anisotropy of magnetic susceptibility (AMS) is sensitive to differential compaction and other rock magnetic parameters like isothermal remanence and anhysteretic remanence are very sensitive to changes in the terrestrial source region. In general, highly anisotropic layers correspond with laminated clay-rich units, while more isotropic layers are bioturbated and have less clay. Layers enriched in diatoms are associated with the latter, which also have higher Ba/Al ratios indicating higher productivity. Higher anisotropy layers have lower porosity and moisture contents and have fine grained magnetic mineralogy dominated by magnetic. Higher anisotropy layers are dominated by maghemite, supporting the suggestion by Cook et al. (2013) of different source regions during low and high productivity times. They tied the two facies to the coastal outcrops of the Lower Paleozoic granitic terranes and the Ferrar Large Igneous Province in the more inland Wilkes Subglacial Basin respectively. Here we present evidence for a third geological unit, one eroded at the boundaries between the high and low clay zones with a "hard" (hematite) dominated magnetic mineralogy. This unit likely outcrops in the Wilkes sub-glacial basin and could be hydrothermally altered Beacon sandstone similar to that detected by Craw and Findlay (1984) in Taylor Valley or the equivalent to the Elatina Formation in the Adelaide Geosyncline in Southern Australia (Schmidt and Williams, 2013). Cook, C. P., van de Flierdt, T., Williams, T., Hemming, S. R., Iwai, M., Kobayashi, M., Jimenez-Espejo, F., Escutia, C., Gonzalez, J., Khim, B. K., McKay, R., Passchier, S., Bohaty, S., Riesselman, C. R., Tauxe, L., Sugisaki, S., Lopez Galindo, A., Patterson, M. O., Sangiorgi, F., Pierce, E. L., Brinkhuis, H., and Scientists, I. E., 2013, Nature Geoscience, v. 6, p. 765-769. Craw, D., and Findlay, R. H., 1984, New Zealand Jour. Geol. Geophys., v. 27, p. 465-475. Schmidt, P. W., and Williams, G. E., 2013, Global and Planetary Change, v. 110, p. 289-301.

The George V Land Continental Margin (East Antarctica): new Insights Into Bottom Water Production and Quaternary Glacial Processes from the WEGA project

NASA Astrophysics Data System (ADS)

Caburlotto, A.; de Santis, L.; Lucchi, R. G.; Giorgetti, G.; Damiani, D.; Macri', P.; Tolotti, R.; Presti, M.; Armand, L.; Harris, P.

2004-12-01

The George Vth Land represents the ending of one of the largest subglacial basin (Wilkes Basin) of the East Antarctic Ice Sheet (EAIS). Furthermore, its coastal areas are zone of significant production of High Salinity Shelf Water (HSSW). Piston and gravity cores and high resolution echo-sounding (3.5 kHz) and Chirp profiles collected in the frame of the joint Australian and Italian WEGA (WilkEs Basin GlAcial History) project provide new insights into the Quaternary history of the EAIS and the HSSW across this margin: from the sediment record filling and draping valleys and banks along the continental shelf, to the continuous sedimentary section of the mound-channel system on the continental rise. The discovery of a current-lain sediment drift (Mertz Drift, MD) provides clues to understanding the age of the last glacial erosive events, as well as to infer flow-pathways of bottom-water masses changes. The MD shows disrupted, fluted reflectors due to glacial advance during the LGM (Last Glacial Maximum) in shallow water, while undisturbed sediment drift deposited at greater water depth, indicates that during the LGM the ice shelf was floating over the deep sector of the basin. The main sedimentary environment characterising the modern conditions of the continental rise is dominated by the turbiditic processes with a minor contribution of contour currents action. Nevertheless, some areas (WEGA Channel) are currently characterised by transport and settling of sediment through HSSW, originating in the shelf area. This particular environment likely persisted since pre-LGM times. It could indicate a continuous supply of sedimentary material from HSSW during the most recent both glacial and interglacial cycles. This would be consistent with the results obtained in the continental shelf suggesting that the Ice Sheet was not grounding over some parts of the continental shelf. Furthermore, the comparison of the studied area with other Antarctic margins indicate that, contrary to what happens on the Antarctic Peninsula margin, the relation between the Quaternary sedimentation and the glacial - interglacial cycles are less evident in the lithofacies observed on the continental rise area. This characteristic suggests a different glacial dynamic along the Wilkes Land continental margin that is less sensitive to the small climatic changes, with respect to the western (Antarctic Peninsula) margin.

Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal.

PubMed

Paudel, Sarad; Mikota, Susan K; Nakajima, Chie; Gairhe, Kamal P; Maharjan, Bhagwan; Thapa, Jeewan; Poudel, Ajay; Shimozuru, Michito; Suzuki, Yasuhiko; Tsubota, Toshio

2014-05-01

Mycobacterium tuberculosis was cultured from the lung tissues of 3 captive elephants in Nepal that died with extensive lung lesions. Spoligotyping, TbD1 detection and multi-locus variable number of tandem repeat analysis (MLVA) results suggested 3 isolates belonged to a specific lineage of Indo-Oceanic clade, EAI5 SIT 138. One of the elephant isolates had a new synonymous single nucleotide polymorphism (SNP) T231C in the gyrA sequence, and the same SNP was also found in human isolates in Nepal. MLVA results and transfer history of the elephants suggested that 2 of them might be infected with M. tuberculosis from the same source. These findings indicated the source of M. tuberculosis infection of those elephants were local residents, presumably their handlers. Further investigation including detailed genotyping of elephant and human isolates is needed to clarify the infection route and eventually prevent the transmission of tuberculosis to susceptible hosts. Copyright © 2014 Elsevier Ltd. All rights reserved.

Isolation of fish skin and bone gelatin from tilapia (Oreochromis niloticus): Response surface approach

NASA Astrophysics Data System (ADS)

Arpi, N.; Fahrizal; Novita, M.

2018-03-01

In this study, gelatin from fish collagen, as one of halal sources, was extracted from tilapia (Oreochromis niloticus) skin and bone, by using Response Surface Methodology to optimize gelatin extraction conditions. Concentrations of alkaline NaOH and acid HCl, in the pretreatment process, and temperatures in extraction process were chosen as independent variables, while dependent variables were yield, gel strength, and emulsion activity index (EAI). The result of investigation showed that lower NaOH pretreatment concentrations provided proper pH extraction conditions which combine with higher extraction temperatures resulted in high gelatin yield. However, gelatin emulsion activity index increased proportionally to the decreased in NaOH concentrations and extraction temperatures. No significant effect of the three independent variables on the gelatin gel strength. RSM optimization process resulted in optimum gelatin extraction process conditions using alkaline NaOH concentration of 0.77 N, acid HCl of 0.59 N, and extraction temperature of 66.80 °C. The optimal solution formula had optimization targets of 94.38%.

Exposure age and ice-sheet model constraints on Pliocene East Antarctic ice sheet dynamics.

PubMed

Yamane, Masako; Yokoyama, Yusuke; Abe-Ouchi, Ayako; Obrochta, Stephen; Saito, Fuyuki; Moriwaki, Kiichi; Matsuzaki, Hiroyuki

2015-04-24

The Late Pliocene epoch is a potential analogue for future climate in a warming world. Here we reconstruct Plio-Pleistocene East Antarctic Ice Sheet (EAIS) variability using cosmogenic nuclide exposure ages and model simulations to better understand ice sheet behaviour under such warm conditions. New and previously published exposure ages indicate interior-thickening during the Pliocene. An ice sheet model with mid-Pliocene boundary conditions also results in interior thickening and suggests that both the Wilkes Subglacial and Aurora Basins largely melted, offsetting increased ice volume. Considering contributions from West Antarctica and Greenland, this is consistent with the most recent IPCC AR5 estimate, which indicates that the Pliocene sea level likely did not exceed +20 m on Milankovitch timescales. The inception of colder climate since ∼3 Myr has increased the sea ice cover and inhibited active moisture transport to Antarctica, resulting in reduced ice sheet thickness, at least in coastal areas.

Pan–ice-sheet glacier terminus change in East Antarctica reveals sensitivity of Wilkes Land to sea-ice changes

PubMed Central

Miles, Bertie W. J.; Stokes, Chris R.; Jamieson, Stewart S. R.

2016-01-01

The dynamics of ocean-terminating outlet glaciers are an important component of ice-sheet mass balance. Using satellite imagery for the past 40 years, we compile an approximately decadal record of outlet-glacier terminus position change around the entire East Antarctic Ice Sheet (EAIS) marine margin. We find that most outlet glaciers retreated during the period 1974–1990, before switching to advance in every drainage basin during the two most recent periods, 1990–2000 and 2000–2012. The only exception to this trend was in Wilkes Land, where the majority of glaciers (74%) retreated between 2000 and 2012. We hypothesize that this anomalous retreat is linked to a reduction in sea ice and associated impacts on ocean stratification, which increases the incursion of warm deep water toward glacier termini. Because Wilkes Land overlies a large marine basin, it raises the possibility of a future sea level contribution from this sector of East Antarctica. PMID:27386519

Pan-ice-sheet glacier terminus change in East Antarctica reveals sensitivity of Wilkes Land to sea-ice changes.

PubMed

Miles, Bertie W J; Stokes, Chris R; Jamieson, Stewart S R

2016-05-01

The dynamics of ocean-terminating outlet glaciers are an important component of ice-sheet mass balance. Using satellite imagery for the past 40 years, we compile an approximately decadal record of outlet-glacier terminus position change around the entire East Antarctic Ice Sheet (EAIS) marine margin. We find that most outlet glaciers retreated during the period 1974-1990, before switching to advance in every drainage basin during the two most recent periods, 1990-2000 and 2000-2012. The only exception to this trend was in Wilkes Land, where the majority of glaciers (74%) retreated between 2000 and 2012. We hypothesize that this anomalous retreat is linked to a reduction in sea ice and associated impacts on ocean stratification, which increases the incursion of warm deep water toward glacier termini. Because Wilkes Land overlies a large marine basin, it raises the possibility of a future sea level contribution from this sector of East Antarctica.

High resolution seismic stratigraphy and sedimentological signature of the Late Quaternary deposits in the northern Western Basin (Ross Sea, Antarctica)

NASA Astrophysics Data System (ADS)

Corradi, N.; Finocchiaro, F.; Ivaldi, R.; Melis, R.; Pittà, A.

2003-04-01

The northern Western Basin is a sector of the continental shelf of the Western Ross Sea that is considered to be the natural northward extension of the Drygalski Basin by many authors. The literature provides a general model of the evolution of the basin and the recent papers propose a seismic stratigraphy for the post-Miocene sedimentation. However, the sedimentary processes during the Late Quaternary and, in particular, the Last Glacial Maximum (LGM) are still little understood (Brambati et al., 2001). In this paper we present the preliminary results of the very high-resolution seismic surveys (Sub Bottom Profiler, Huntec Deep Tow Boomer and Sparker) and their calibration with the sediment samples collected during the three Marine Geology Campaigns of the PNRA (XIII, XIV and XVII), with the scientific objective of the research to investigate the role of the East Antarctic Ice Sheet (EAIS) in the morphogenesis and deposition of the Late Quaternary sedimentary series.

HYDES: A generalized hybrid computer program for studying turbojet or turbofan engine dynamics

NASA Technical Reports Server (NTRS)

Szuch, J. R.

1974-01-01

This report describes HYDES, a hybrid computer program capable of simulating one-spool turbojet, two-spool turbojet, or two-spool turbofan engine dynamics. HYDES is also capable of simulating two- or three-stream turbofans with or without mixing of the exhaust streams. The program is intended to reduce the time required for implementing dynamic engine simulations. HYDES was developed for running on the Lewis Research Center's Electronic Associates (EAI) 690 Hybrid Computing System and satisfies the 16384-word core-size and hybrid-interface limits of that machine. The program could be modified for running on other computing systems. The use of HYDES to simulate a single-spool turbojet and a two-spool, two-stream turbofan engine is demonstrated. The form of the required input data is shown and samples of output listings (teletype) and transient plots (x-y plotter) are provided. HYDES is shown to be capable of performing both steady-state design and off-design analyses and transient analyses.

A new airborne geophysical platform and its application in the Princess Elizabeth Land during CHINARE 32 and 33 in East Antarctica

NASA Astrophysics Data System (ADS)

Cui, Xiangbin; Sun, Bo; Guo, Jingxue; Tang, Xueyuan; Greenbaum, Jamin; Lindzey, Laura; Habbal, Feras; Young, Duncan

2017-04-01

The ice thickness, subglacial topography and bedrock conditions of Princess Elizabeth Land (PEL) in central East Antarctic Ice Sheet (EAIS) are still unknown due to lack of direct geophysical measurements. This prevents our understanding of the ice sheet dynamics, subglacial morphology and climate evolution in the region. According to recent results from remote sensing results, it's very likely that there's a large, previously undiscovered subglacial lake and subglacial drainage networks existing beneath the ice sheet in PEL with possible subglacial canyons extend over a distance of 1100 km from inland to coast. But there's no direct measurements to identify them yet. China deployed its first fixed-wing airplane named Snow Eagle 601 and implemented airborne geophysical investigation in PEL during the 32nd and 33rd Chinese National Antarctic Research Expeditions (CHINARE 32 and 33, 2015/16 and 2016/17). The HiCARS deep ice-penetrating radar system and other instruments including GT-2A gravimeter, CS-3 magnetometer, laser altimeter, GPS and camera, were installed in the airplane to measure the ice sheet and subglacial conditions, as well as bedrock geology and tectonic. The field campaign was built beside Russian airfield (ZGN) near Zhongshan Station. During CHINARE 32, the airborne surveying grid was designed as radial lines from ZGN so as to investigate the region as large as possible, and total flight lines are 32 000 km. During the CHINARE 33, airborne survey will pay attention to the subglacial lake and subglacal canyons. Here, we introduce the Snow Eagle airborne geophysical platform firstly. Then, we present some preliminary results from CHINARE 32 and CHINARE 33.

General purpose PDP-11 interface processor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Purtilo, J.

1982-10-01

The Z80 interface card, which for simplicity we refer to as the Zcard, is a general purpose microprocessor which is directly interfaced to the Whaley multiplexor, itself implemented on PDP-11 series computers at the University of Illinois. The Zcard provides two serial ports at EAI interface levels and contains up to 16K of local memory. The principle function of the Zcard is to serve as an interface in which the user might alter protocols, change interface characteristics (e.g. baud rate, hardware echo, or flow control), or switch between synchronous and asynchronous modes all under software control. In addition, the Zcardmore » provides extra lines for control of external devices (e.g. modem) and input of status data. In the simpliest use, the Zcard runs a program, downloaded from the PDP-11, which emulates the level EIAFB card (previously developed for the Whaley Multiplexor) for serial communication with terminals. Using no flow control, Zcard performance seems superior to that of the EIAFB card in that no characters are lost under normal use (due to the much larger buffer which the Zcard can provide). The Zcard can further distinguish itself from the EIAFB card in that flow control can be enabled by software. A more sophisticated application of the Zcard might include linking several Zcards (using a synchronous option and both of the provided ports) into a network. In this capacity, a ring topology suggests itself as the most immediate choice, although many alternate connection schemes can be envisioned. This report is intended to summarize the project as well as provide an outline for those intending to modify or program the Zcard.« less

Nutrients removal and substrate enzyme activities in vertical subsurface flow constructed wetlands for mariculture wastewater treatment: Effects of ammonia nitrogen loading rates and salinity levels.

PubMed

Li, Meng; Liang, Zhenlin; Callier, Myriam D; Roque d'orbcastel, Emmanuelle; Sun, Guoxiang; Ma, Xiaona; Li, Xian; Wang, Shunkui; Liu, Ying; Song, Xiefa

2018-06-01

This study aims to investigate the effects of ammonia nitrogen loading rates and salinity levels on nutrients removal rates and substrate enzyme activities of constructed wetland (CW) microcosms planted with Salicornia bigelovii treating mariculture wastewater. Activities of urease (UA), dehydrogenase (DA), protease (PrA) and phosphatase (PA) were considered. Using principal component analysis (PCA), nutrient removal index (NRI) and enzyme activity index (EAI) were developed to evaluate the effects. The results revealed that increasing ammonia nitrogen loading rates had positive effects on nitrogen removal rates (i.e. NH 4 -N and DIN) and enhanced substrate enzyme activities. Compared with low salinity (i.e. 15 and 22), high salinity levels (i.e. 29 and 36) enhanced nutrients removal rates, DA and UA, but weaken PA and PrA. In conclusion, CW microcosms with Salicornia bigelovii can be used for the removal of nutrients under a range of ammonia nitrogen loadings and high salinity levels. Copyright © 2018 Elsevier Ltd. All rights reserved.

Cenozoic ice sheet history from East Antarctic Wilkes Land continental margin sediments

USGS Publications Warehouse

Escutia, C.; De Santis, L.; Donda, F.; Dunbar, R.B.; Cooper, A. K.; Brancolini, Giuliano; Eittreim, S.L.

2005-01-01

The long-term history of glaciation along the East Antarctic Wilkes Land margin, from the time of the first arrival of the ice sheet to the margin, through the significant periods of Cenozoic climate change is inferred using an integrated geophysical and geological approach. We postulate that the first arrival of the ice sheet to the Wilkes Land margin resulted in the development of a large unconformity (WL-U3) between 33.42 and 30 Ma during the early Oligocene cooling climate trend. Above WL-U3, substantial margin progradation takes place with early glacial strata (e.g., outwash deposits) deposited as low-angle prograding foresets by temperate glaciers. The change in geometry of the prograding wedge across unconformity WL-U8 is interpreted to represent the transition, at the end of the middle Miocene "climatic optimum" (14-10 Ma), from a subpolar regime with dynamic ice sheets (i.e., ice sheets come and go) to a regime with persistent but oscillatory ice sheets. The steep foresets above WL-U8 likely consist of ice proximal sediments (i.e., water-lain till and debris flows) deposited when grounded ice-sheets extended into the shelf. On the continental rise, shelf progradation above WL-U3 results in an up-section increase in the energy of the depositional environment (i.e., seismic facies indicative of more proximal turbidite and of bottom contour current deposition from the deposition of the lower WL-S5 sequence to WL-S7). Maximum rates of sediment delivery to the rise occur during the development of sequences WL-S6 and WL-S7, which we infer to be of middle Miocene age. During deposition of the two uppermost sequences, WL-S8 and WL-S9, there is a marked decrease in the sediment supply to the lower continental rise and a shift in the depocenters to more proximal areas of the margin. We believe WL-S8 records sedimentation during the final transition from a dynamic to a persistent but oscillatory ice sheet in this margin (14-10 Ma). Sequence WL-S9 forms under a polar regime during the Pliocene-Pleistocene, when most sediment delivered to the margin is trapped in the outer shelf and slope-forming steep prograding wedges. During the warmer but still polar, Holocene, biogenic sediment accumulates quickly in deep inner-shelf basins during the high-stand intervals. These sediments contain an ultrahigh resolution (annual to millennial) record of climate variability. Validation of our inferences about the nature and timing of Wilkes Land glacial sequences can be achieved by deep sampling (i.e., using IODP-type techniques). The most complete record of the long-term history of glaciation in this margin can be obtained by sampling both (1) the shelf, which contains the direct (presence or no presence of ice) but low-resolution record of glaciation, and (2) the rise, which contains the distal (cold vs. warm) but more complete record of glaciation. The Wilkes Land margin is the only known Antarctic margin where the presumed "onset" of glaciation unconformity (WL-U3) can be traced from shelf to the abyssal plain, allowing links between the proximal and the distal records of glaciation to be established. Additionally, the eastern segment of the Wilkes Land margin may be more sensitive to climate change because the East Antarctic Ice Sheet (EAIS) is grounded below sea level. Therefore, the Wilkes Land margin is not only an ideal location to obtain the long-term EAIS history but also to obtain the shorter-term record of ice sheet fluctuations at times that the East Antarctic Ice Sheet is thought to have been more stable (after 15 Ma-recent). ?? 2004 Elsevier B.V. All rights reserved.

The Future of Healthcare Informatics: It Is Not What You Think

PubMed Central

2012-01-01

Electronic health records (EHRs) offer many valuable benefits for patient safety, but it becomes apparent that the effective application of healthcare informatics creates problems and unintended consequences. One problem that seems particularly challenging is integration. Painfully missing are low-cost, easy to implement, plug-and-play, nonintrusive integration solutions—healthcare's “killer app.” Why is this? We must stop confusing application integration with information integration. Our goal must be to communicate data (ie, integrate information), not to integrate application functionality via complex and expensive application program interfaces (APIs). Communicating data simply requires a loosely coupled flow of data, as occurs today via email. In contrast, integration is a chief information officer's nightmare. Integrating applications, when we just wanted a bit of information, is akin to killing a gnat with a brick. PMID:24278826

Integrated learning: ways of fostering the applicability of teachers’ pedagogical and psychological knowledge

PubMed Central

Harr, Nora; Eichler, Andreas; Renkl, Alexander

2015-01-01

In teacher education, general pedagogical and psychological knowledge (PPK) is often taught separately from the teaching subject itself, potentially leading to inert knowledge. In an experimental study with 69 mathematics student teachers, we tested the benefits of fostering the integration of pedagogical content knowledge (PCK) and general PPK with respect to knowledge application. Integration was fostered either by integrating the contents or by prompting the learners to integrate separately taught knowledge. Fostering integration, as compared to a separate presentation without integration help, led to more applicable PPK and greater simultaneous application of PPK and PCK. The advantages of fostering knowledge integration were not moderated by the student teachers’ prior knowledge or working memory capacity. A disadvantage of integrating different knowledge types referred to increased learning times. PMID:26082740

Integrating CLIPS applications into heterogeneous distributed systems

NASA Technical Reports Server (NTRS)

Adler, Richard M.

1991-01-01

SOCIAL is an advanced, object-oriented development tool for integrating intelligent and conventional applications across heterogeneous hardware and software platforms. SOCIAL defines a family of 'wrapper' objects called agents, which incorporate predefined capabilities for distributed communication and control. Developers embed applications within agents and establish interactions between distributed agents via non-intrusive message-based interfaces. This paper describes a predefined SOCIAL agent that is specialized for integrating C Language Integrated Production System (CLIPS)-based applications. The agent's high-level Application Programming Interface supports bidirectional flow of data, knowledge, and commands to other agents, enabling CLIPS applications to initiate interactions autonomously, and respond to requests and results from heterogeneous remote systems. The design and operation of CLIPS agents are illustrated with two distributed applications that integrate CLIPS-based expert systems with other intelligent systems for isolating and mapping problems in the Space Shuttle Launch Processing System at the NASA Kennedy Space Center.

Design of Integrated Database on Mobile Information System: A Study of Yogyakarta Smart City App

NASA Astrophysics Data System (ADS)

Nurnawati, E. K.; Ermawati, E.

2018-02-01

An integration database is a database which acts as the data store for multiple applications and thus integrates data across these applications (in contrast to an Application Database). An integration database needs a schema that takes all its client applications into account. The benefit of the schema that sharing data among applications does not require an extra layer of integration services on the applications. Any changes to data made in a single application are made available to all applications at the time of database commit - thus keeping the applications’ data use better synchronized. This study aims to design and build an integrated database that can be used by various applications in a mobile device based system platforms with the based on smart city system. The built-in database can be used by various applications, whether used together or separately. The design and development of the database are emphasized on the flexibility, security, and completeness of attributes that can be used together by various applications to be built. The method used in this study is to choice of the appropriate database logical structure (patterns of data) and to build the relational-database models (Design Databases). Test the resulting design with some prototype apps and analyze system performance with test data. The integrated database can be utilized both of the admin and the user in an integral and comprehensive platform. This system can help admin, manager, and operator in managing the application easily and efficiently. This Android-based app is built based on a dynamic clientserver where data is extracted from an external database MySQL. So if there is a change of data in the database, then the data on Android applications will also change. This Android app assists users in searching of Yogyakarta (as smart city) related information, especially in culture, government, hotels, and transportation.

Providing an integrated clinical data view in a hospital information system that manages multimedia data.

PubMed

Dayhoff, R E; Maloney, D L; Kenney, T J; Fletcher, R D

1991-01-01

The VA's hospital information system, the Decentralized Hospital Computer Program (DHCP), is an integrated system based on a powerful set of software tools with shared data accessible from any of its application modules. It includes many functionally specific application subsystems such as laboratory, pharmacy, radiology, and dietetics. Physicians need applications that cross these application boundaries to provide useful and convenient patient data. One of these multi-specialty applications, the DHCP Imaging System, integrates multimedia data to provide clinicians with comprehensive patient-oriented information. User requirements for cross-disciplinary image access can be studied to define needs for similar text data access. Integration approaches must be evaluated both for their ability to deliver patient-oriented text data rapidly and their ability to integrate multimedia data objects. Several potential integration approaches are described as they relate to the DHCP Imaging System.

Providing an integrated clinical data view in a hospital information system that manages multimedia data.

PubMed Central

Dayhoff, R. E.; Maloney, D. L.; Kenney, T. J.; Fletcher, R. D.

1991-01-01

The VA's hospital information system, the Decentralized Hospital Computer Program (DHCP), is an integrated system based on a powerful set of software tools with shared data accessible from any of its application modules. It includes many functionally specific application subsystems such as laboratory, pharmacy, radiology, and dietetics. Physicians need applications that cross these application boundaries to provide useful and convenient patient data. One of these multi-specialty applications, the DHCP Imaging System, integrates multimedia data to provide clinicians with comprehensive patient-oriented information. User requirements for cross-disciplinary image access can be studied to define needs for similar text data access. Integration approaches must be evaluated both for their ability to deliver patient-oriented text data rapidly and their ability to integrate multimedia data objects. Several potential integration approaches are described as they relate to the DHCP Imaging System. PMID:1807651

Effects of acylation on the functional properties and in vitro trypsin digestibility of red kidney bean (Phaseolus vulgaris L.) protein isolate.

PubMed

Yin, Shou-Wei; Tang, Chuan-He; Wen, Qi-Biao; Yang, Xiao-Quan

2009-01-01

The effects of succinylation and acetylation on some functional properties and the in vitro trypsin digestibility of kidney bean protein isolate (KPI) were investigated. The extent of succinylation or acetylation progressively increased from 0% to 96% to 97%, as the anhydride-to-protein ratio increased from 0 to 1 g/g. Polyacrylamide gel electrophoresis (PAGE) and zeta potential analyses indicated that acylation, especially succinylation, considerably increased the net charge and hydrodynamic radius of the proteins in KPI, especially vicilin. Acylation treatment at various anhydride-to-protein ratios (0.05 to 1 g/g) remarkably improved the protein solubility (PS) and emulsifying activity index (EAI) at neutral pH, but the improvement by succinylation was much better than that by acetylation. Succinylation resulted in a marked decrease in mechanical moduli of heat-induced gels of KPI, while the mechanical moduli were, on the contrary, increased by acetylation. Additionally, in vitro trypsin digestibility was improved by the acylation in an anhydride-type and level-dependent manner. The results suggest that the functional properties of KPI could be modulated by the chemical acylation treatment, using succinic or acetic anhydride at appropriate anhydride-to-protein ratios.

Contamination source review for Building E3180, Edgewood Area, Aberdeen Proving Ground, Maryland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zellmer, S.D.; Smits, M.P.; Rueda, J.

1995-09-01

This report was prepared by Argonne National Laboratory (ANL) to document the results of a contamination source review of Building E3180 at the Aberdeen Proving Ground (APG) in Maryland. The report may be used to assist the US Army in planning for the future use or disposition of this building. The review included a historical records search, physical inspection, photographic documentation, geophysical investigation, collection of air samples, and review of available records regarding underground storage tanks associated with Building E3180. The field investigations were performed by ANL during 1994. Building,E3180 (current APG designation) is located near the eastern end ofmore » Kings Creek Road, north of Kings Creek, and about 0.5 miles east of the airstrip within APG`s Edgewood Area. The building was constructed in 1944 as a facsimile of a Japanese pillbox and used for the development of flame weapons systems until 1957 (EAI Corporation 1989). The building was not used from 1957 until 1965, when it was converted and used as a flame and incendiary laboratory. During the 1970s, the building was converted to a machine (metal) shop and used for that purpose until 1988.« less

Prevalence of Mycobacterium tuberculosis strain genotypes in Taiwan reveals a close link to ethnic and population migration.

PubMed

Dou, Horng-Yunn; Chen, Yih-Yuan; Kou, Shu-Chen; Su, Ih-Jen

2015-06-01

Taiwan is a relatively isolated island, serving as a mixing vessel for colonization by different waves of ethnic and migratory groups over the past 4 centuries. The potential transmission pattern of Mycobacterium tuberculosis in different ethnic and migratory populations remains to be elucidated. By using mycobacterial tandem repeat sequences as genetic markers, the prevalence of M. tuberculosis strains in Taiwan revealed a close link to the historical migration. Interestingly, the M. tuberculosis strain in the aborigines of Eastern and Central Taiwan had a dominance of the Haarlem (Dutch) strain while those in Southern Taiwan had a dominance of the East-African Indian (EAI) strain. The prevalence of different M. tuberculosis strains in specific ethnic populations suggests that M. tuberculosis transmission is limited and restricted to close contact. The prevalence of the Beijing modern strain in the young population causes a concern for M. tuberculosis control, because of high virulence and drug resistance. Furthermore, our data using molecular genotyping should provide valuable information on the historical study of the origin and migration of aborigines in Taiwan. Copyright © 2014. Published by Elsevier B.V.

Equine-Assisted Intervention in a child diagnosed with autism spectrum disorder: a case report.

PubMed

Cerino, Stefania; Borgi, Marta; Fiorentini, Ilaria; Correale, Cinzia; Lori, Alessia; Cirulli, Francesca

2016-01-01

An increasing number of studies have shown the beneficial effects of both recreational and therapeutic interventions assisted by animals for children with Autism Spectrum Disorders (ASD). The observed effects are believed to be mainly due to the ability of some animals to positively engage people, thus potentially counteracting the social withdrawal characterizing these subjects. Here we report the case of a child with high-functioning autism who has been included in an Equine-Assisted Intervention (EAI) program for 2 years. In particular, the relationship with the animal was used to encourage child’s narrative abilities as a primary means of improving cognition and communication. This case represents a first attempt to theorize the role of human-animal interaction as an adjunct to classic therapeutic strategies in ASD. During the intervention, the child appeared to gradually abandon his attitude to avoid the contact with the present and to hide in imaginative past and future. We propose animal-assisted interventions as complementary approaches capable to facilitate the verbalization of the patient’s internal states and to promote psychological well-being through the development of a bond with the animal.

Research on application information system integration platform in medicine manufacturing enterprise.

PubMed

Deng, Wu; Zhao, Huimin; Zou, Li; Li, Yuanyuan; Li, Zhengguang

2012-08-01

Computer and information technology popularizes in the medicine manufacturing enterprise for its potentials in working efficiency and service quality. In allusion to the explosive data and information of application system in current medicine manufacturing enterprise, we desire to propose a novel application information system integration platform in medicine manufacturing enterprise, which based on a combination of RFID technology and SOA, to implement information sharing and alternation. This method exploits the application integration platform across service interface layer to invoke the RFID middleware. The loose coupling in integration solution is realized by Web services. The key techniques in RFID event components and expanded role-based security access mechanism are studied in detail. Finally, a case study is implemented and tested to evidence our understanding on application system integration platform in medicine manufacturing enterprise.

A Review of "Integrity[TM]"

ERIC Educational Resources Information Center

Veldkamp, Bernard P.

2008-01-01

Integrity[TM], an online application for testing both the statistical integrity of the test and the academic integrity of the examinees, was evaluated for this review. Program features and the program output are described. An overview of the statistics in Integrity[TM] is provided, and the application is illustrated with a small simulation study.…

Strategies to support drug discovery through integration of systems and data.

PubMed

Waller, Chris L; Shah, Ajay; Nolte, Matthias

2007-08-01

Much progress has been made over the past several years to provide technologies for the integration of drug discovery software applications and the underlying data bits. Integration at the application layer has focused primarily on developing and delivering applications that support specific workflows within the drug discovery arena. A fine balance between creating behemoth applications and providing business value must be maintained. Heterogeneous data sources have typically been integrated at the data level in an effort to provide a more holistic view of the data packages supporting key decision points. This review will highlight past attempts, current status, and potential future directions for systems and data integration strategies in support of drug discovery efforts.

Gel integration for microfluidic applications.

PubMed

Zhang, Xuanqi; Li, Lingjun; Luo, Chunxiong

2016-05-21

Molecular diffusive membranes or materials are important for biological applications in microfluidic systems. Hydrogels are typical materials that offer several advantages, such as free diffusion for small molecules, biocompatibility with most cells, temperature sensitivity, relatively low cost, and ease of production. With the development of microfluidic applications, hydrogels can be integrated into microfluidic systems by soft lithography, flow-solid processes or UV cure methods. Due to their special properties, hydrogels are widely used as fluid control modules, biochemical reaction modules or biological application modules in different applications. Although hydrogels have been used in microfluidic systems for more than ten years, many hydrogels' properties and integrated techniques have not been carefully elaborated. Here, we systematically review the physical properties of hydrogels, general methods for gel-microfluidics integration and applications of this field. Advanced topics and the outlook of hydrogel fabrication and applications are also discussed. We hope this review can help researchers choose suitable methods for their applications using hydrogels.

Enhanced Continental Weathering on Antarctica During the Mid Miocene Climatic Optima Based on Pb Isotopes

NASA Astrophysics Data System (ADS)

Martin, E. E.; Fenn, C.; Basak, C.

2012-12-01

Feedbacks between climate and continental weathering can be monitored over geologic time scales using Pb isotopes preserved in marine sediments. During chemical weathering, radiogenic Pb is preferentially released to the dissolved phase, producing weathering solutions with more radiogenic isotopic values than the parent rock. The offset between the composition of the solution and rock tend to increase with the intensity of incongruent weathering (von Blanckenburg and Nägler, 2001; Harlavan and Erel, 2002). The seawater isotopic signal extracted from Fe-Mn oxides on bulk marine sediments is interpreted to represent the composition of local dissolved weathering inputs. For example, increasing seawater Pb isotopes observed during the most recent deglaciation are believed to reflect enhanced weathering of newly exposed glacial rock flour under warm conditions (Foster and Vance, 2006; Kurzweil et al., 2010). For this study we evaluated Nd and Pb isotopes from both the seawater fraction (extracted from Fe-Mn oxides) and parent rock (the detrital fraction of marine sediment) during the Mid-Miocene Climatic Optimum (MMCO) and subsequent cooling and East Antarctic Ice Sheet (EAIS) expansion (18 to 8 Ma) from Ocean Drilling Program site 744 on Kerguelen Plateau (2300 m; Indian sector) and sites 689 and 690 on Maud Rise (2080 m and 2914 m; Atlantic sector). The absolute value of seawater 206Pb/204Pb and separation between values for seawater and detrital fractions increased during the MMCO, suggesting enhanced weathering in proglacial and deglaciated areas exposed by ice sheet meltback during the warm interval. During the ensuing cooling, seawater values and the offset between the two archives decreased. Similar trends are displayed by 207Pb/204Pb and 208Pb/204Pb, although 207Pb/204Pb detrital values tend to be higher than seawater values. Reconstructions of atmospheric pCO2 in the Miocene have suggested both 1) decoupling between pCO2 and climate with consistently low, modern concentrations throughout the Miocene (Pagani et al., 2005; Pearson and Palmer, 2000), and 2) a correlation between higher pCO2 during the MMCO and decreasing values during cooling and re-establishment of a full-scale EAIS (Royer et al., 2001; Kürschner et al., 2008; Tripati et al., 2009; Foster et al., 2012). Our data suggest enhanced weathering during the MMCO would have contributed to a drawdown of CO2 leading to cooling, thereby supporting a correlation between climate and pCO2 in the Miocene. Nd isotopes may also fractionate during weathering. Our seawater Nd isotopes are consistently more radiogenic than detrital values, but there is no relationship between the magnitude of offset and climate conditions. Instead, documented depth stratification and regional distribution of seawater Nd isotopes in the water column indicate the Nd signal is dominated by water mass advection.

Seawater and Detrital Marine Pb Isotopes as Monitors of Antarctic Weathering Following Ice Sheet Development

NASA Astrophysics Data System (ADS)

Fenn, C.; Martin, E. E.; Basak, C.

2011-12-01

Comparisons of seawater and detrital Pb isotopes from sites proximal to Antarctica at the Eocene/Oligocene transition (EOT) are being used to understand variations in continental weathering associated with the development of the East Antarctic Ice Sheet (EAIS). Previous work has shown that seawater and detrital archives yield similar isotopic values during Eocene warmth, which is interpreted to record congruent chemical weathering of the continent. In contrast, distinct isotopic values for the two phases at the EOT represents increased incongruent mechanical weathering during growth of the ice sheet. For this study we expanded beyond the initial glaciation at the EOT to determine whether less dramatic changes in ice volume and climate also produce variations in weathering and intensity that are recorded by seawater and detrital Pb isotopes. We collected Nd and Pb isotope data from extractions of Fe-Mn oxide coatings of bulk decarbonated marine sediments, which preserve seawater isotopic values, and from complete dissolutions of the remaining silicate fraction for Ocean Drilling Program Site 748 on Kerguelen Plateau (1300 m modern water depth). The data spans an interval of deglaciation from ~23.5-27 Ma documented by δ18O that has been equated to a ~30% decrease in ice volume on Antarctica (Pekar and Christie-Blick, 2008, Palaeogeogr., Palaeoclim., Palaeoecol.). Initial results from Site 748 include the first ɛNd values for intermediate waters in the Oligocene Southern Ocean and reveal a value of ~-8 over the entire 3.5 my interval, which is consistent with values reported for deep Indian Ocean sites at this time and similar to deeper Southern Ocean sites. Corresponding detrital ɛNd values are less radiogenic and decrease from -9 to -13 during the study interval. Detrital 206Pb/204Pb values also decrease during the warming interval, while seawater 206Pb/204Pb values increase. The decrease in detrital values indicates the composition of source materials entering the ocean changed as the ice sheet waned. Increasing seawater 206Pb/204Pb may record enhanced chemical weathering under conditions of greater water availability and warmer temperatures combined with abundant rock flour created during the preceding glacial advance. As previous studies have documented initial weathering leachates tend to be more radiogenic than the parent rock composition. Alternatively, seawater values during warming in the late Oligocene approach values recorded during initial ice sheet expansion at the EOT in Site 738, which may suggest Pb isotope variations in seawater and detrital residues are not sensitive to less dramatic intervals of climate change and ice sheet dynamics. We plan to continue this study into the Pliocene to see if we can identify the timing of the transition from a wet-based to dry-based EAIS, an event that is likely to have profound consequences for weathering on Antarctica and the offset between the two Pb isotope archives.

HIS/BUI: a conceptual model for bottom-up integration of hospital information systems.

PubMed

Zviran, M; Armoni, A; Glezer, C

1998-06-01

Many successful applications of information systems have been introduced and implemented in hospitals. However, the integration of these applications into a cohesive hospital-wide information system has proved to be more complicated to develop and difficult to accomplish than expected. This paper introduces HIS/BUI, a framework for bottom-up integration of hospital information systems, and demonstrates its application through a real-life case scenario. The scope of the proposed framework is the integration of heterogeneous clinical, administrative, and financial information elements of a hospital into a unified system environment. Under the integrated architecture, all existing local applications are preserved and interconnected to an information hub that serves as a central medical and administrative data warehouse.

Boutiques: a flexible framework to integrate command-line applications in computing platforms.

PubMed

Glatard, Tristan; Kiar, Gregory; Aumentado-Armstrong, Tristan; Beck, Natacha; Bellec, Pierre; Bernard, Rémi; Bonnet, Axel; Brown, Shawn T; Camarasu-Pop, Sorina; Cervenansky, Frédéric; Das, Samir; Ferreira da Silva, Rafael; Flandin, Guillaume; Girard, Pascal; Gorgolewski, Krzysztof J; Guttmann, Charles R G; Hayot-Sasson, Valérie; Quirion, Pierre-Olivier; Rioux, Pierre; Rousseau, Marc-Étienne; Evans, Alan C

2018-05-01

We present Boutiques, a system to automatically publish, integrate, and execute command-line applications across computational platforms. Boutiques applications are installed through software containers described in a rich and flexible JSON language. A set of core tools facilitates the construction, validation, import, execution, and publishing of applications. Boutiques is currently supported by several distinct virtual research platforms, and it has been used to describe dozens of applications in the neuroinformatics domain. We expect Boutiques to improve the quality of application integration in computational platforms, to reduce redundancy of effort, to contribute to computational reproducibility, and to foster Open Science.

Development of Mobile Electronic Health Records Application in a Secondary General Hospital in Korea

PubMed Central

Park, Min Ah; Hong, Eunseok; Kim, Sunhyu; Ahn, Ryeok; Hong, Jungseok; Song, Seungyeol; Kim, Tak; Kim, Jeongkeun; Yeo, Seongwoon

2013-01-01

Objectives The recent evolution of mobile devices has opened new possibilities of providing strongly integrated mobile services in healthcare. The objective of this paper is to describe the decision driver, development, and implementation of an integrated mobile Electronic Health Record (EHR) application at Ulsan University Hospital. This application helps healthcare providers view patients' medical records and information without a stationary computer workstation. Methods We developed an integrated mobile application prototype that aimed to improve the mobility and usability of healthcare providers during their daily medical activities. The Android and iOS platform was used to create the mobile EHR application. The first working version was completed in 5 months and required 1,080 development hours. Results The mobile EHR application provides patient vital signs, patient data, text communication, and integrated EHR. The application allows our healthcare providers to know the status of patients within and outside the hospital environment. The application provides a consistent user environment on several compatible Android and iOS devices. A group of 10 beta testers has consistently used and maintained our copy of the application, suggesting user acceptance. Conclusions We are developing the integrated mobile EHR application with the goals of implementing an environment that is user-friendly, implementing a patient-centered system, and increasing the hospital's competitiveness. PMID:24523996

Development of mobile electronic health records application in a secondary general hospital in Korea.

PubMed

Choi, Wookjin; Park, Min Ah; Hong, Eunseok; Kim, Sunhyu; Ahn, Ryeok; Hong, Jungseok; Song, Seungyeol; Kim, Tak; Kim, Jeongkeun; Yeo, Seongwoon

2013-12-01

The recent evolution of mobile devices has opened new possibilities of providing strongly integrated mobile services in healthcare. The objective of this paper is to describe the decision driver, development, and implementation of an integrated mobile Electronic Health Record (EHR) application at Ulsan University Hospital. This application helps healthcare providers view patients' medical records and information without a stationary computer workstation. We developed an integrated mobile application prototype that aimed to improve the mobility and usability of healthcare providers during their daily medical activities. The Android and iOS platform was used to create the mobile EHR application. The first working version was completed in 5 months and required 1,080 development hours. The mobile EHR application provides patient vital signs, patient data, text communication, and integrated EHR. The application allows our healthcare providers to know the status of patients within and outside the hospital environment. The application provides a consistent user environment on several compatible Android and iOS devices. A group of 10 beta testers has consistently used and maintained our copy of the application, suggesting user acceptance. We are developing the integrated mobile EHR application with the goals of implementing an environment that is user-friendly, implementing a patient-centered system, and increasing the hospital's competitiveness.

Boutiques: a flexible framework to integrate command-line applications in computing platforms

PubMed Central

Glatard, Tristan; Kiar, Gregory; Aumentado-Armstrong, Tristan; Beck, Natacha; Bellec, Pierre; Bernard, Rémi; Bonnet, Axel; Brown, Shawn T; Camarasu-Pop, Sorina; Cervenansky, Frédéric; Das, Samir; Ferreira da Silva, Rafael; Flandin, Guillaume; Girard, Pascal; Gorgolewski, Krzysztof J; Guttmann, Charles R G; Hayot-Sasson, Valérie; Quirion, Pierre-Olivier; Rioux, Pierre; Rousseau, Marc-Étienne; Evans, Alan C

2018-01-01

Abstract We present Boutiques, a system to automatically publish, integrate, and execute command-line applications across computational platforms. Boutiques applications are installed through software containers described in a rich and flexible JSON language. A set of core tools facilitates the construction, validation, import, execution, and publishing of applications. Boutiques is currently supported by several distinct virtual research platforms, and it has been used to describe dozens of applications in the neuroinformatics domain. We expect Boutiques to improve the quality of application integration in computational platforms, to reduce redundancy of effort, to contribute to computational reproducibility, and to foster Open Science. PMID:29718199

Approximations First: A Closer Look at Applications of the Definite Integral

ERIC Educational Resources Information Center

Brandt, Keith

2017-01-01

I propose that students pay more attention to the approximations that lead to integral formulas when they study applications of the definite integral. The goal is to focus students on the underlying concepts and the definition of the definite integral--and to steer them away from memorizing formulas. To address this goal, I have written some…

New Challenges in Information Integration

NASA Astrophysics Data System (ADS)

Haas, Laura M.; Soffer, Aya

Information integration is the cornerstone of modern business informatics. It is a pervasive problem; rarely is a new application built without an initial phase of gathering and integrating information. Information integration comes in a wide variety of forms. Historically, two major approaches were recognized: data federation and data warehousing. Today, we need new approaches, as information integration becomes more dynamic, while coping with growing volumes of increasingly dirty and diverse data. At the same time, information integration must be coupled more tightly with the applications and the analytics that will leverage the integrated results, to make the integration process more tractable and the results more consumable.

REPRESENTATIONS OF WEAK AND STRONG INTEGRALS IN BANACH SPACES

PubMed Central

Brooks, James K.

1969-01-01

We establish a representation of the Gelfand-Pettis (weak) integral in terms of unconditionally convergent series. Moreover, absolute convergence of the series is a necessary and sufficient condition in order that the weak integral coincide with the Bochner integral. Two applications of the representation are given. The first is a simplified proof of the countable additivity and absolute continuity of the indefinite weak integral. The second application is to probability theory; we characterize the conditional expectation of a weakly integrable function. PMID:16591755

Ceramic Integration Technologies for Aerospace and Energy Systems: Technical Challenges and Opportunities

NASA Technical Reports Server (NTRS)

Singh, Mrityunjay

2007-01-01

Ceramic integration technology has been recognized as an enabling technology for the implementation of advanced ceramic systems in a number of high-temperature applications in aerospace, power generation, nuclear, chemical, and electronic industries. Various ceramic integration technologies (joining, brazing, attachments, repair, etc.) play a role in fabrication and manufacturing of large and complex shaped parts of various functionalities. However, the development of robust and reliable integrated systems with optimum performance requires the understanding of many thermochemical and thermomechanical factors, particularly for high temperature applications. In this presentation, various challenges and opportunities in design, fabrication, and testing of integrated similar (ceramic-ceramic) and dissimilar (ceramic-metal) material systems will be discussed. Experimental results for bonding and integration of SiC based LDI fuel injector, high conductivity C/C composite based heat rejection system, solid oxide fuel cells system, ultra high temperature ceramics for leading edges, and ceramic composites for thermostructural applications will be presented. Potential opportunities and need for the development of innovative design philosophies, approaches, and integrated system testing under simulated application conditions will also be discussed.

75 FR 53355 - The Integrity Funds, et al.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... and Integrity Money Management, Inc., a wholly owned subsidiary of Integrity Mutual Funds, Inc.... SUMMARY: Summary of Application: The requested order would permit certain registered open-end management... Fund'' and collectively, the ``Mutual Funds''), and Viking Fund Management, LLC (the ``Adviser...

Semantic Web meets Integrative Biology: a survey.

PubMed

Chen, Huajun; Yu, Tong; Chen, Jake Y

2013-01-01

Integrative Biology (IB) uses experimental or computational quantitative technologies to characterize biological systems at the molecular, cellular, tissue and population levels. IB typically involves the integration of the data, knowledge and capabilities across disciplinary boundaries in order to solve complex problems. We identify a series of bioinformatics problems posed by interdisciplinary integration: (i) data integration that interconnects structured data across related biomedical domains; (ii) ontology integration that brings jargons, terminologies and taxonomies from various disciplines into a unified network of ontologies; (iii) knowledge integration that integrates disparate knowledge elements from multiple sources; (iv) service integration that build applications out of services provided by different vendors. We argue that IB can benefit significantly from the integration solutions enabled by Semantic Web (SW) technologies. The SW enables scientists to share content beyond the boundaries of applications and websites, resulting into a web of data that is meaningful and understandable to any computers. In this review, we provide insight into how SW technologies can be used to build open, standardized and interoperable solutions for interdisciplinary integration on a global basis. We present a rich set of case studies in system biology, integrative neuroscience, bio-pharmaceutics and translational medicine, to highlight the technical features and benefits of SW applications in IB.

Database integration for investigative data visualization with the Temporal Analysis System

NASA Astrophysics Data System (ADS)

Barth, Stephen W.

1997-02-01

This paper describes an effort to provide mechanisms for integration of existing law enforcement databases with the temporal analysis system (TAS) -- an application for analysis and visualization of military intelligence data. Such integration mechanisms are essential for bringing advanced military intelligence data handling software applications to bear on the analysis of data used in criminal investigations. Our approach involved applying a software application for intelligence message handling to the problem of data base conversion. This application provides mechanisms for distributed processing and delivery of converted data records to an end-user application. It also provides a flexible graphic user interface for development and customization in the field.

Numerical methods for engine-airframe integration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murthy, S.N.B.; Paynter, G.C.

1986-01-01

Various papers on numerical methods for engine-airframe integration are presented. The individual topics considered include: scientific computing environment for the 1980s, overview of prediction of complex turbulent flows, numerical solutions of the compressible Navier-Stokes equations, elements of computational engine/airframe integrations, computational requirements for efficient engine installation, application of CAE and CFD techniques to complete tactical missile design, CFD applications to engine/airframe integration, and application of a second-generation low-order panel methods to powerplant installation studies. Also addressed are: three-dimensional flow analysis of turboprop inlet and nacelle configurations, application of computational methods to the design of large turbofan engine nacelles, comparison ofmore » full potential and Euler solution algorithms for aeropropulsive flow field computations, subsonic/transonic, supersonic nozzle flows and nozzle integration, subsonic/transonic prediction capabilities for nozzle/afterbody configurations, three-dimensional viscous design methodology of supersonic inlet systems for advanced technology aircraft, and a user's technology assessment.« less

Migrating data from TcSE to DOORS : an evaluation of the T-Plan Integrator software application.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Post, Debra S.; Manzanares, David A.; Taylor, Jeffrey L.

2011-02-01

This report describes our evaluation of the T-Plan Integrator software application as it was used to transfer a real data set from the Teamcenter for Systems Engineering (TcSE) software application to the DOORS software application. The T-Plan Integrator was evaluated to determine if it would meet the needs of Sandia National Laboratories to migrate our existing data sets from TcSE to DOORS. This report presents the struggles of migrating data and focuses on how the Integrator can be used to map a data set and its data architecture from TcSE to DOORS. Finally, this report describes how the bulk ofmore » the migration can take place using the Integrator; however, about 20-30% of the data would need to be transferred from TcSE to DOORS manually. This report does not evaluate the transfer of data from DOORS to TcSE.« less

Characterisation of pks15/1 in clinical isolates of Mycobacterium tuberculosis from Mexico

PubMed Central

Zenteno-Cuevas, Roberto; Silva-Hernández, Francisco X; Mendoza-Damián, Fabiola; Ramírez-Hernández, Maria Dolores; Vázquez-Medina, Karen; Widrobo-García, Lorena; Cuellar-Sanchez, Aremy; Muñíz-Salazar, Raquel; Enciso-Moreno, Leonor; Pérez-Navarro, Lucia Monserrat; Enciso-Moreno, José Antonio

2013-01-01

Tuberculosis (TB) is an infectocontagious respiratory disease caused by members of the Mycobacterium tuberculosis complex. A 7 base pair (bp) deletion in the locus polyketide synthase (pks)15/1 is described as polymorphic among members of the M. tuberculosis complex, enabling the identification of Euro-American, Indo-Oceanic and Asian lineages. The aim of this study was to characterise this locus in TB isolates from Mexico. One hundred twenty clinical isolates were recovered from the states of Veracruz and Estado de Mexico. We determined the nucleotide sequence of a ± 400 bp fragment of the locus pks15/1, while genotypic characterisation was performed by spoligotyping. One hundred and fifty isolates contained the 7 bp deletion, while five had the wild type locus. Lineages X (22%), LAM (18%) and T (17%) were the most frequent; only three (2%) of the isolates were identified as Beijing and two (1%) EAI-Manila. The wild type pks15/1 locus was observed in all Asian lineage isolates tested. Our results confirm the utility of locus pks15/1 as a molecular marker for identifying Asian lineages of the M. tuberculosis complex. This marker could be of great value in the epidemiological surveillance of TB, especially in countries like Mexico, where the prevalence of such lineages is unknown. PMID:24037193

Exploring low-income families' financial barriers to food allergy management and treatment.

PubMed

Minaker, Leia M; Elliott, Susan J; Clarke, Ann

2014-01-01

Objectives. Low-income families may face financial barriers to management and treatment of chronic illnesses. No studies have explored how low-income individuals and families with anaphylactic food allergies cope with financial barriers to anaphylaxis management and/or treatment. This study explores qualitatively assessed direct, indirect, and intangible costs of anaphylaxis management and treatment faced by low-income families. Methods. In-depth, semistructured interviews with 23 participants were conducted to gain insight into income-related barriers to managing and treating anaphylactic food allergies. Results. Perceived direct costs included the cost of allergen-free foods and allergy medication and costs incurred as a result of misinformation about social support programs. Perceived indirect costs included those associated with lack of continuity of health care. Perceived intangible costs included the stress related to the difficulty of obtaining allergen-free foods at the food bank and feeling unsafe at discount grocery stores. These perceived costs represented barriers that were perceived as especially salient for the working poor, immigrants, youth living in poverty, and food bank users. Discussion. Low-income families report significant financial barriers to food allergy management and anaphylaxis preparedness. Clinicians, advocacy groups, and EAI manufacturers all have a role to play in ensuring equitable access to medication for low-income individuals with allergies.

Recent high-resolution Antarctic ice velocity maps reveal increased mass loss in Wilkes Land, East Antarctica.

PubMed

Shen, Qiang; Wang, Hansheng; Shum, C K; Jiang, Liming; Hsu, Hou Tse; Dong, Jinglong

2018-03-14

We constructed Antarctic ice velocity maps from Landsat 8 images for the years 2014 and 2015 at a high spatial resolution (100 m). These maps were assembled from 10,690 scenes of displacement vectors inferred from more than 10,000 optical images acquired from December 2013 through March 2016. We estimated the mass discharge of the Antarctic ice sheet in 2008, 2014, and 2015 using the Landsat ice velocity maps, interferometric synthetic aperture radar (InSAR)-derived ice velocity maps (~2008) available from prior studies, and ice thickness data. An increased mass discharge (53 ± 14 Gt yr -1 ) was found in the East Indian Ocean sector since 2008 due to unexpected widespread glacial acceleration in Wilkes Land, East Antarctica, while the other five oceanic sectors did not exhibit significant changes. However, present-day increased mass loss was found by previous studies predominantly in west Antarctica and the Antarctic Peninsula. The newly discovered increased mass loss in Wilkes Land suggests that the ocean heat flux may already be influencing ice dynamics in the marine-based sector of the East Antarctic ice sheet (EAIS). The marine-based sector could be adversely impacted by ongoing warming in the Southern Ocean, and this process may be conducive to destabilization.

Fabrication of nano-scale Cu bond pads with seal design in 3D integration applications.

PubMed

Chen, K N; Tsang, C K; Wu, W W; Lee, S H; Lu, J Q

2011-04-01

A method to fabricate nano-scale Cu bond pads for improving bonding quality in 3D integration applications is reported. The effect of Cu bonding quality on inter-level via structural reliability for 3D integration applications is investigated. We developed a Cu nano-scale-height bond pad structure and fabrication process for improved bonding quality by recessing oxides using a combination of SiO2 CMP process and dilute HF wet etching. In addition, in order to achieve improved wafer-level bonding, we introduced a seal design concept that prevents corrosion and provides extra mechanical support. Demonstrations of these concepts and processes provide the feasibility of reliable nano-scale 3D integration applications.

An introduction to Lie group integrators – basics, new developments and applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Celledoni, Elena, E-mail: elenac@math.ntnu.no; Marthinsen, Håkon, E-mail: hakonm@math.ntnu.no; Owren, Brynjulf, E-mail: bryn@math.ntnu.no

2014-01-15

We give a short and elementary introduction to Lie group methods. A selection of applications of Lie group integrators are discussed. Finally, a family of symplectic integrators on cotangent bundles of Lie groups is presented and the notion of discrete gradient methods is generalised to Lie groups.

Some new retarded nonlinear Volterra-Fredholm type integral inequalities with maxima in two variables and their applications.

PubMed

Xu, Run; Ma, Xiangting

2017-01-01

In this paper, we establish some new retarded nonlinear Volterra-Fredholm type integral inequalities with maxima in two independent variables, and we present the applications to research the boundedness of solutions to retarded nonlinear Volterra-Fredholm type integral equations.

An Integrated Software Package to Enable Predictive Simulation Capabilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yousu; Fitzhenry, Erin B.; Jin, Shuangshuang

The power grid is increasing in complexity due to the deployment of smart grid technologies. Such technologies vastly increase the size and complexity of power grid systems for simulation and modeling. This increasing complexity necessitates not only the use of high-performance-computing (HPC) techniques, but a smooth, well-integrated interplay between HPC applications. This paper presents a new integrated software package that integrates HPC applications and a web-based visualization tool based on a middleware framework. This framework can support the data communication between different applications. Case studies with a large power system demonstrate the predictive capability brought by the integrated software package,more » as well as the better situational awareness provided by the web-based visualization tool in a live mode. Test results validate the effectiveness and usability of the integrated software package.« less

A pilot study for the integration of cytometry reports in digital cytology telemedicine applications.

PubMed

Giansanti, Daniele; Cerroni, Fabio; Amodeo, Rachele; Filoni, Marco; Giovagnoli, Maria Rosaria

2010-01-01

Up to date, tele-pathology in the three different forms of application, "dynamic", "static" and "virtual microscopy" has been mainly based on tele-hystology remote consulting. Today the diffusion of specialized WAN connections is guiding the research of new applications of tele-pathology. A specific analysis has been conducted, focused on digital cytology, in the biomedical laboratory of Sant'Andrea Hospital to investigate the technologies potentially useful to integrate in the LAN/WAN for telemedicine applications. Among the possible tools useful to be integrated in the LAN/WAN for telemedicine applications, the cytometry equipment available in the technical unity of cytometry has been considered important. The study finally provides a proposal for a tele-consulting architecture for the integration of cytometry reports both in the hospital LAN and the WAN for possible cooperative diagnosis and second opinion support.

Integrating Carbon Nanotubes For Atomic Force Microscopy Imaging Applications

NASA Technical Reports Server (NTRS)

Ye, Qi; Cassell, Alan M.; Liu, Hongbing; Han, Jie; Meyyappan, Meyya

2004-01-01

Carbon nanotube (CNT) related nanostructures possess remarkable electrical, mechanical, and thermal properties. To produce these nanostructures for real world applications, a large-scale controlled growth of carbon nanotubes is crucial for the integration and fabrication of nanodevices and nanosensors. We have taken the approach of integrating nanopatterning and nanomaterials synthesis with traditional silicon micro fabrication techniques. This integration requires a catalyst or nanomaterial protection scheme. In this paper, we report our recent work on fabricating wafer-scale carbon nanotube AFM cantilever probe tips. We will address the design and fabrication considerations in detail, and present the preliminary scanning probe test results. This work may serve as an example of rational design, fabrication, and integration of nanomaterials for advanced nanodevice and nanosensor applications.

System integration test plan for HANDI 2000 business management system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, D.

This document presents the system integration test plan for the Commercial-Off-The-Shelf, PassPort and PeopleSoft software, and custom software created to work with the COTS products. The PP software is an integrated application for AP, Contract Management, Inventory Management, Purchasing and Material Safety Data Sheet. The PS software is an integrated application for Project Costing, General Ledger, Human Resources/Training, Payroll, and Base Benefits.

Integration of Web-based and PC-based clinical research databases.

PubMed

Brandt, C A; Sun, K; Charpentier, P; Nadkarni, P M

2004-01-01

We have created a Web-based repository or data library of information about measurement instruments used in studies of multi-factorial geriatric health conditions (the Geriatrics Research Instrument Library - GRIL) based upon existing features of two separate clinical study data management systems. GRIL allows browsing, searching, and selecting measurement instruments based upon criteria such as keywords and areas of applicability. Measurement instruments selected can be printed and/or included in an automatically generated standalone microcomputer database application, which can be downloaded by investigators for use in data collection and data management. Integration of database applications requires the creation of a common semantic model, and mapping from each system to this model. Various database schema conflicts at the table and attribute level must be identified and resolved prior to integration. Using a conflict taxonomy and a mapping schema facilitates this process. Critical conflicts at the table level that required resolution included name and relationship differences. A major benefit of integration efforts is the sharing of features and cross-fertilization of applications created for similar purposes in different operating environments. Integration of applications mandates some degree of metadata model unification.

Integration of Geographical Information Systems and Geophysical Applications with Distributed Computing Technologies.

NASA Astrophysics Data System (ADS)

Pierce, M. E.; Aktas, M. S.; Aydin, G.; Fox, G. C.; Gadgil, H.; Sayar, A.

2005-12-01

We examine the application of Web Service Architectures and Grid-based distributed computing technologies to geophysics and geo-informatics. We are particularly interested in the integration of Geographical Information System (GIS) services with distributed data mining applications. GIS services provide the general purpose framework for building archival data services, real time streaming data services, and map-based visualization services that may be integrated with data mining and other applications through the use of distributed messaging systems and Web Service orchestration tools. Building upon on our previous work in these areas, we present our current research efforts. These include fundamental investigations into increasing XML-based Web service performance, supporting real time data streams, and integrating GIS mapping tools with audio/video collaboration systems for shared display and annotation.

The Cenozoic history of East Antarctic subglacial erosion and sediment flux from the offshore detrital thermochronometric record

NASA Astrophysics Data System (ADS)

Thomson, S. N.; Reiners, P. W.; Tochilin, C. J.; Hemming, S. R.; Gehrels, G. E.

2011-12-01

To improve and better quantify the record of subglacial erosion and landscape evolution in East Antarctica since the inception of the East Antarctic ice sheet (EAIS) at 34 Ma we have developed a novel technique to triple-date single grains of detrital apatite by U-Pb, fission track, and (U-Th)/He dating. We applied this method to offshore sediments deposited from the Cretaceous through Holocene in Prydz Bay. The modern source region of Prydz Bay incorporates the Lambert Glacier catchment that drains some 20% of the EAIS. In pre-glacial times, landscape reconstructions and sediment analysis imply that Prydz Bay was the site of deposition of fluvial sediments draining large parts of the East Antarctic craton including parts of the now-subglacial Gamburtsev Mountains. Apatite U-Pb ages from samples through the whole stratigraphic section show a dominant Pan-African age signature (ca. 500 Ma) implying much of the Lambert catchment experienced Pan-African metamorphism to temperatures > ca. 500°C. Pre-glacial Late Cretaceous and Eocene fluvial sandstones are characterized by old apatite fission track (AFT) and (U-Th)/He (AHe) ages between about 300 and 220 Ma. AFT and AHe single grain age pairs show two distinct groups, one indicative of fast cooling and erosion during the Permian followed by residence at low near-surface temperatures until the Eocene, and the other indicative of more constant, but very slow erosion rates (<0.02 km/Myr) since the Permian. A few ages between 110-120 Ma are seen in some Late Cretaceous sediments diagnostic of resetting related to local basic magmatism associated with Kerguelen plume activity seen in very localized catchment bedrock exposures. Importantly, our thermochronometric data from pre-glacial (Eocene and older) sediments show no evidence for any enhanced Cretaceous erosion in the Lambert Graben catchment area, despite the almost certain presence of the >2500 m high Gamburtsev mountains. These old ages are indicative of a slowly eroding, low relief landscape since the Permian, and are consistent with the widespread pre-glacial planar erosion surface seen in much of East Antarctica. AFT and AHe age distributions in post-glacial late Miocene to Holocene diamictite show a spread to significantly younger ages (mean ages of ca. 200±50 and 80±30 Ma, respectively). These younger ages are diagnostic of locally enhanced catchment erosion rates in excess of 0.1 km/Myr. Modeled predictions of the age-temperature (depth) profile at 34 Ma indicate the youngest detrital AFT-AHe age pairs seen in sediments as old as late Miocene represent grains previously resident at temperatures of 40-55°C (ca. 2 km) prior to the onset of glaciation. This is in excellent agreement with published morphologic estimates of >2 km of glacial incision into the pre-glacial peneplain at the head of the Lambert glacier. Our results imply that the majority of glacial incision and erosion in East Antarctica was accomplished sometime between the earliest Oligocene and late Miocene.

Use of Continuous Integration Tools for Application Performance Monitoring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vergara Larrea, Veronica G; Joubert, Wayne; Fuson, Christopher B

High performance computing systems are becom- ing increasingly complex, both in node architecture and in the multiple layers of software stack required to compile and run applications. As a consequence, the likelihood is increasing for application performance regressions to occur as a result of routine upgrades of system software components which interact in complex ways. The purpose of this study is to evaluate the effectiveness of continuous integration tools for application performance monitoring on HPC systems. In addition, this paper also describes a prototype system for application perfor- mance monitoring based on Jenkins, a Java-based continuous integration tool. The monitoringmore » system described leverages several features in Jenkins to track application performance results over time. Preliminary results and lessons learned from monitoring applications on Cray systems at the Oak Ridge Leadership Computing Facility are presented.« less

An Integrated Model of Knowledge Acquisition and Innovation: Examining the Mediation Effects of Knowledge Integration and Knowledge Application

ERIC Educational Resources Information Center

Dahiyat, Samer E.

2015-01-01

The aim of this research is to empirically investigate the relationships among the three vital knowledge management processes of acquisition, integration and application, and their effects on organisational innovation in the pharmaceutical manufacturing industry in Jordan; a knowledge-intensive business service (KIBS) sector. Structural equation…

Cloud Applications in Language Teaching: Examining Pre-Service Teachers' Expertise, Perceptions and Integration

ERIC Educational Resources Information Center

Aburezeq, Ibtehal Mahmoud; Dweikat, Fawzi Fayez Ishtaiwa

2017-01-01

This study examined pre-service teachers' expertise, perceptions and integration of cloud applications in teaching of Arabic and English. Questionnaires and semi-structured interviews were used as data collection methods. The findings of the study specified that pre-service teachers did not own sufficient expertise for effective integration of…

7 CFR 4290.1940 - Integration of this part with other regulations applicable to USDA's programs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Integration of this part with other regulations applicable to USDA's programs. 4290.1940 Section 4290.1940 Agriculture Regulations of the Department of... AGRICULTURE RURAL BUSINESS INVESTMENT COMPANY (âRBICâ) PROGRAM Miscellaneous § 4290.1940 Integration of this...

Silicon photonic integrated circuit swept-source optical coherence tomography receiver with dual polarization, dual balanced, in-phase and quadrature detection.

PubMed

Wang, Zhao; Lee, Hsiang-Chieh; Vermeulen, Diedrik; Chen, Long; Nielsen, Torben; Park, Seo Yeon; Ghaemi, Allan; Swanson, Eric; Doerr, Chris; Fujimoto, James

2015-07-01

Optical coherence tomography (OCT) is a widely used three-dimensional (3D) optical imaging method with many biomedical and non-medical applications. Miniaturization, cost reduction, and increased functionality of OCT systems will be critical for future emerging clinical applications. We present a silicon photonic integrated circuit swept-source OCT (SS-OCT) coherent receiver with dual polarization, dual balanced, in-phase and quadrature (IQ) detection. We demonstrate multiple functional capabilities of IQ polarization resolved detection including: complex-conjugate suppressed full-range OCT, polarization diversity detection, and polarization-sensitive OCT. To our knowledge, this is the first demonstration of a silicon photonic integrated receiver for OCT. The integrated coherent receiver provides a miniaturized, low-cost solution for SS-OCT, and is also a key step towards a fully integrated high speed SS-OCT system with good performance and multi-functional capabilities. With further performance improvement and cost reduction, photonic integrated technology promises to greatly increase penetration of OCT systems in existing applications and enable new applications.

Silicon photonic integrated circuit swept-source optical coherence tomography receiver with dual polarization, dual balanced, in-phase and quadrature detection

PubMed Central

Wang, Zhao; Lee, Hsiang-Chieh; Vermeulen, Diedrik; Chen, Long; Nielsen, Torben; Park, Seo Yeon; Ghaemi, Allan; Swanson, Eric; Doerr, Chris; Fujimoto, James

2015-01-01

Optical coherence tomography (OCT) is a widely used three-dimensional (3D) optical imaging method with many biomedical and non-medical applications. Miniaturization, cost reduction, and increased functionality of OCT systems will be critical for future emerging clinical applications. We present a silicon photonic integrated circuit swept-source OCT (SS-OCT) coherent receiver with dual polarization, dual balanced, in-phase and quadrature (IQ) detection. We demonstrate multiple functional capabilities of IQ polarization resolved detection including: complex-conjugate suppressed full-range OCT, polarization diversity detection, and polarization-sensitive OCT. To our knowledge, this is the first demonstration of a silicon photonic integrated receiver for OCT. The integrated coherent receiver provides a miniaturized, low-cost solution for SS-OCT, and is also a key step towards a fully integrated high speed SS-OCT system with good performance and multi-functional capabilities. With further performance improvement and cost reduction, photonic integrated technology promises to greatly increase penetration of OCT systems in existing applications and enable new applications. PMID:26203382

Integration of aerial imaging and variable-rate technology for site-specific aerial herbicide application

USDA-ARS?s Scientific Manuscript database

As remote sensing and variable rate technology are becoming more available for aerial applicators, practical methodologies on effective integration of these technologies are needed for site-specific aerial applications of crop production and protection materials. The objectives of this study were to...

Integration of GMR Sensors with Different Technologies

PubMed Central

Cubells-Beltrán, María-Dolores; Reig, Càndid; Madrenas, Jordi; De Marcellis, Andrea; Santos, Joana; Cardoso, Susana; Freitas, Paulo P.

2016-01-01

Less than thirty years after the giant magnetoresistance (GMR) effect was described, GMR sensors are the preferred choice in many applications demanding the measurement of low magnetic fields in small volumes. This rapid deployment from theoretical basis to market and state-of-the-art applications can be explained by the combination of excellent inherent properties with the feasibility of fabrication, allowing the real integration with many other standard technologies. In this paper, we present a review focusing on how this capability of integration has allowed the improvement of the inherent capabilities and, therefore, the range of application of GMR sensors. After briefly describing the phenomenological basis, we deal on the benefits of low temperature deposition techniques regarding the integration of GMR sensors with flexible (plastic) substrates and pre-processed CMOS chips. In this way, the limit of detection can be improved by means of bettering the sensitivity or reducing the noise. We also report on novel fields of application of GMR sensors by the recapitulation of a number of cases of success of their integration with different heterogeneous complementary elements. We finally describe three fully functional systems, two of them in the bio-technology world, as the proof of how the integrability has been instrumental in the meteoric development of GMR sensors and their applications. PMID:27338415

System Engineering of Photonic Systems for Space Application

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Pryor, Jonathan E.

2014-01-01

The application of photonics in space systems requires tight integration with the spacecraft systems to ensure accurate operation. This requires some detailed and specific system engineering to properly incorporate the photonics into the spacecraft architecture and to guide the spacecraft architecture in supporting the photonics devices. Recent research in product focused, elegant system engineering has led to a system approach which provides a robust approach to this integration. Focusing on the mission application and the integration of the spacecraft system physics incorporation of the photonics can be efficiently and effectively accomplished. This requires a clear understanding of the driving physics properties of the photonics device to ensure proper integration with no unintended consequences. The driving physics considerations in terms of optical performance will be identified for their use in system integration. Keywords: System Engineering, Optical Transfer Function, Optical Physics, Photonics, Image Jitter, Launch Vehicle, System Integration, Organizational Interaction

An evaluation of the availability, accessibility, and quality of online content of vascular surgery training program websites for residency and fellowship applicants.

PubMed

Huang, Bryant Y; Hicks, Taylor D; Haidar, Georges M; Pounds, Lori L; Davies, Mark G

2017-12-01

Vascular surgery residency and fellowship applicants commonly seek information about programs from the Internet. Lack of an effective web presence curtails the ability of programs to attract applicants, and in turn applicants may be unable to ascertain which programs are the best fit for their career aspirations. This study was designed to evaluate the presence, accessibility, comprehensiveness, and quality of vascular surgery training websites (VSTW). A list of accredited vascular surgery training programs (integrated residencies and fellowships) was obtained from four databases for vascular surgery education: the Accreditation Council for Graduate Medical Education, Electronic Residency Application Service, Fellowship and Residency Electronic Interactive Database, and Society for Vascular Surgery. Programs participating in the 2016 National Resident Matching Program were eligible for study inclusion. Accessibility of VSTW was determined by surveying the Accreditation Council for Graduate Medical Education, Electronic Residency Application Service, and Fellowship and Residency Electronic Interactive Database for the total number of programs listed and for the presence or absence of website links. VSTW were analyzed for the availability of recruitment and education content items. The quality of VSTW was determined as a composite of four dimensions: content, design, organization, and user friendliness. Percent agreements and kappa statistics were calculated for inter-rater reliability. Eighty-nine of the 94 fellowship (95%) and 45 of the 48 integrated residencies (94%) programs participating in the 2016 Match had a VSTW. For program recruitment, evaluators found an average of 12 of 32 content items (35.0%) for fellowship programs and an average of 12 of 32 (37%) for integrated residencies. Only 47.1% of fellowship programs (53% integrated residencies) specified the number of positions available for the 2016 Match, 20% (13% integrated residencies) indicated alumni career placement, 34% (38% integrated residencies) supplied interview dates, and merely 17% (18% integrated residencies) detailed the selection process. For program education, fellowship websites provided an average of 5.1 of 15 content items (34.0%), and integrated residency websites provided 5 of 14 items (34%). Of the fellowship programs, 66% (84.4% integrated residencies) provided a rotation schedule, 65% (56% integrated residencies) detailed operative experiences, 38% (38% integrated residencies) posted conference schedules, and just 16% (28.9% integrated residencies) included simulation training. The web presence of vascular surgery training programs lacks sufficient accessibility, content, organization, design, and user friendliness to allow applicants to access information that informs them sufficiently. There are opportunities to more effectively use VSTW for the benefit of training programs and prospective applicants. Copyright © 2017 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Integration of USB and firewire cameras in machine vision applications

NASA Astrophysics Data System (ADS)

Smith, Timothy E.; Britton, Douglas F.; Daley, Wayne D.; Carey, Richard

1999-08-01

Digital cameras have been around for many years, but a new breed of consumer market cameras is hitting the main stream. By using these devices, system designers and integrators will be well posited to take advantage of technological advances developed to support multimedia and imaging applications on the PC platform. Having these new cameras on the consumer market means lower cost, but it does not necessarily guarantee ease of integration. There are many issues that need to be accounted for like image quality, maintainable frame rates, image size and resolution, supported operating system, and ease of software integration. This paper will describe briefly a couple of the consumer digital standards, and then discuss some of the advantages and pitfalls of integrating both USB and Firewire cameras into computer/machine vision applications.

Application of remote sensing and Geographic Information Systems to ecosystem-based urban natural resource management

Treesearch

Xiaohui Zhang; George Ball; Eve Halper

2000-01-01

This paper presents an integrated system to support urban natural resource management. With the application of remote sensing (RS) and geographic information systems (GIS), the paper emphasizes the methodology of integrating information technology and a scientific basis to support ecosystem-based management. First, a systematic integration framework is developed and...

26 CFR 1.401(e)-5 - Limitation of contribution and benefit bases to first $100,000 of annual compensation in case of...

Code of Federal Regulations, 2010 CFR

2010-04-01

... benefits under the plan on account of such integration. See also subsections (a)(5), (a)(15), and (d)(6) of...) for a special prohibition against integration. (c) Application of nondiscrimination requirement. (1...)(6) and all other integration requirements applicable to qualified defined contribution plans. The...

Ceramic Integration Technologies for Energy and Aerospace Applications

NASA Technical Reports Server (NTRS)

Singh, Mrityunjay; Asthana, Ralph N.

2007-01-01

Robust and affordable integration technologies for advanced ceramics are required to improve the performance, reliability, efficiency, and durability of components, devices, and systems based on them in a wide variety of energy, aerospace, and environmental applications. Many thermochemical and thermomechanical factors including joint design, analysis, and optimization must be considered in integration of similar and dissimilar material systems.

A study of methods to predict and measure the transmission of sound through the walls of light aircraft. Integration of certain singular boundary element integrals for applications in linear acoustics

NASA Technical Reports Server (NTRS)

Zimmerle, D.; Bernhard, R. J.

1985-01-01

An alternative method for performing singular boundary element integrals for applications in linear acoustics is discussed. The method separates the integral of the characteristic solution into a singular and nonsingular part. The singular portion is integrated with a combination of analytic and numerical techniques while the nonsingular portion is integrated with standard Gaussian quadrature. The method may be generalized to many types of subparametric elements. The integrals over elements containing the root node are considered, and the characteristic solution for linear acoustic problems are examined. The method may be generalized to most characteristic solutions.

Evaluating Simultaneous Integrals

ERIC Educational Resources Information Center

Kwong, Harris

2012-01-01

Many integrals require two successive applications of integration by parts. During the process, another integral of similar type is often invoked. We propose a method which can integrate these two integrals simultaneously. All we need is to solve a linear system of equations.

Elliptic polylogarithms and iterated integrals on elliptic curves. II. An application to the sunrise integral

NASA Astrophysics Data System (ADS)

Broedel, Johannes; Duhr, Claude; Dulat, Falko; Tancredi, Lorenzo

2018-06-01

We introduce a class of iterated integrals that generalize multiple polylogarithms to elliptic curves. These elliptic multiple polylogarithms are closely related to similar functions defined in pure mathematics and string theory. We then focus on the equal-mass and non-equal-mass sunrise integrals, and we develop a formalism that enables us to compute these Feynman integrals in terms of our iterated integrals on elliptic curves. The key idea is to use integration-by-parts identities to identify a set of integral kernels, whose precise form is determined by the branch points of the integral in question. These kernels allow us to express all iterated integrals on an elliptic curve in terms of them. The flexibility of our approach leads us to expect that it will be applicable to a large variety of integrals in high-energy physics.

Optical printed circuit board (O-PCB) and VLSI photonic integrated circuits: visions, challenges, and progresses

NASA Astrophysics Data System (ADS)

Lee, El-Hang; Lee, S. G.; O, B. H.; Park, S. G.; Noh, H. S.; Kim, K. H.; Song, S. H.

2006-09-01

A collective overview and review is presented on the original work conducted on the theory, design, fabrication, and in-tegration of micro/nano-scale optical wires and photonic devices for applications in a newly-conceived photonic systems called "optical printed circuit board" (O-PCBs) and "VLSI photonic integrated circuits" (VLSI-PIC). These are aimed for compact, high-speed, multi-functional, intelligent, light-weight, low-energy and environmentally friendly, low-cost, and high-volume applications to complement or surpass the capabilities of electrical PCBs (E-PCBs) and/or VLSI electronic integrated circuit (VLSI-IC) systems. These consist of 2-dimensional or 3-dimensional planar arrays of micro/nano-optical wires and circuits to perform the functions of all-optical sensing, storing, transporting, processing, switching, routing and distributing optical signals on flat modular boards or substrates. The integrated optical devices include micro/nano-scale waveguides, lasers, detectors, switches, sensors, directional couplers, multi-mode interference devices, ring-resonators, photonic crystal devices, plasmonic devices, and quantum devices, made of polymer, silicon and other semiconductor materials. For VLSI photonic integration, photonic crystals and plasmonic structures have been used. Scientific and technological issues concerning the processes of miniaturization, interconnection and integration of these systems as applicable to board-to-board, chip-to-chip, and intra-chip integration, are discussed along with applications for future computers, telecommunications, and sensor-systems. Visions and challenges toward these goals are also discussed.

Aerospace Sensor Systems: From Sensor Development To Vehicle Application

NASA Technical Reports Server (NTRS)

Hunter, Gary W.

2008-01-01

This paper presents an overview of years of sensor system development and application for aerospace systems. The emphasis of this work is on developing advanced capabilities for measurement and control of aeropropulsion and crew vehicle systems as well as monitoring the safety of those systems. Specific areas of work include chemical species sensors, thin film thermocouples and strain gages, heat flux gages, fuel gages, SiC based electronic devices and sensors, space qualified electronics, and MicroElectroMechanical Systems (MEMS) as well as integrated and multifunctional sensor systems. Each sensor type has its own technical challenges related to integration and reliability in a given application. The general approach has been to develop base sensor technology using microfabrication techniques, integrate sensors with "smart" hardware and software, and demonstrate those systems in a range of aerospace applications. Descriptions of the sensor elements, their integration into sensors systems, and examples of sensor system applications will be discussed. Finally, suggestions related to the future of sensor technology will be given. It is concluded that smart micro/nano sensor technology can revolutionize aerospace applications, but significant challenges exist in maturing the technology and demonstrating its value in real-life applications.

Technical support plan for HANDI 2000 business management system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, D.E.

The Hanford Data Integration 2000 (HANDI 2000) Project will result in an integrated and comprehensive set of functional applications containing core information necessary to support the Project Hanford Management Contract. It is based on the Commercial-Off-The-Shelf (COTS) product solution with commercially proven business processes. The PassPort (PP) software is an integrated application for Accounts Payable, Contract Management, Inventory Management, and Purchasing. The PeopleSoft (PS) software is an integrated application for General Ledger, Project Costing, Human Resources, Payroll, Benefits, and Training. The implementation of this set of products, as the first deliverable of the HAND1 2000 Project, is referred to asmore » Business Management System (BMS) and Chemical Management.« less

Micro-optics for microfluidic analytical applications.

PubMed

Yang, Hui; Gijs, Martin A M

2018-02-19

This critical review summarizes the developments in the integration of micro-optical elements with microfluidic platforms for facilitating detection and automation of bio-analytical applications. Micro-optical elements, made by a variety of microfabrication techniques, advantageously contribute to the performance of an analytical system, especially when the latter has microfluidic features. Indeed the easy integration of optical control and detection modules with microfluidic technology helps to bridge the gap between the macroscopic world and chip-based analysis, paving the way for automated and high-throughput applications. In our review, we start the discussion with an introduction of microfluidic systems and micro-optical components, as well as aspects of their integration. We continue with a detailed description of different microfluidic and micro-optics technologies and their applications, with an emphasis on the realization of optical waveguides and microlenses. The review continues with specific sections highlighting the advantages of integrated micro-optical components in microfluidic systems for tackling a variety of analytical problems, like cytometry, nucleic acid and protein detection, cell biology, and chemical analysis applications.

Advances in the NASA Earth Science Division Applied Science Program

NASA Astrophysics Data System (ADS)

Friedl, L.; Bonniksen, C. K.; Escobar, V. M.

2016-12-01

The NASA Earth Science Division's Applied Science Program advances the understanding of and ability to used remote sensing data in support of socio-economic needs. The integration of socio-economic considerations in to NASA Earth Science projects has advanced significantly. The large variety of acquisition methods used has required innovative implementation options. The integration of application themes and the implementation of application science activities in flight project is continuing to evolve. The creation of the recently released Earth Science Division, Directive on Project Applications Program and the addition of an application science requirement in the recent EVM-2 solicitation document NASA's current intent. Continuing improvement in the Earth Science Applications Science Program are expected in the areas of thematic integration, Project Applications Program tailoring for Class D missions and transfer of knowledge between scientists and projects.

Photorefractive Integrators and Correlators

DTIC Science & Technology

1992-12-01

The use of photorefractive crystals as optically addressed time integrating spatial light modulators in acousto - optic signal processing applications...adaptive acousto - optic processor. These results demonstrated the feasibility of using photorefractives for such applications.... Photorefractive, Acousto - optic processor.

Proceedings of the International Conference on Integrated Micro/Nanotechnology for Space Applications

NASA Technical Reports Server (NTRS)

1995-01-01

The recent evolution of microelectronic technologies coupled with the growth of micro-electro-mechanical systems (MEMS) has had significant impact in the commercial sector. The focus of this conference was to anticipate and extend the incorporation of nano-electronics and MEMS into application specific integrated microinstruments (ASIM's) in space systems. Presentations ranged from mission application of nano-satellites to silicon micromachining for photonic applications.

Survey of Federal, National, and International standards applicable to the NASA applications data services

NASA Technical Reports Server (NTRS)

Kuch, T.; Sakamoto, R.

1981-01-01

An applications data service (ADS) was developed to meet the challenges in the data access and integration. The ADS provides a common service to locate and access applications data electronically and integrate the cross correlative data sets required by multiple users. Its catalog and network services increase data visibility as well as provide the data in a more rapid manner and a usable form.

Rotated waveplates in integrated waveguide optics.

PubMed

Corrielli, Giacomo; Crespi, Andrea; Geremia, Riccardo; Ramponi, Roberta; Sansoni, Linda; Santinelli, Andrea; Mataloni, Paolo; Sciarrino, Fabio; Osellame, Roberto

2014-06-25

Controlling and manipulating the polarization state of a light beam is crucial in applications ranging from optical sensing to optical communications, both in the classical and quantum regime, and ultimately whenever interference phenomena are to be exploited. In addition, many of these applications present severe requirements of phase stability and greatly benefit from a monolithic integrated-optics approach. However, integrated devices that allow arbitrary transformations of the polarization state are very difficult to produce with conventional lithographic technologies. Here we demonstrate waveguide-based optical waveplates, with arbitrarily rotated birefringence axis, fabricated by femtosecond laser pulses. To validate our approach, we exploit this component to realize a compact device for the quantum state tomography of two polarization-entangled photons. This work opens perspectives for integrated manipulation of polarization-encoded information with relevant applications ranging from integrated polarimetric sensing to quantum key distribution.

High-performance silicon photonics technology for telecommunications applications.

PubMed

Yamada, Koji; Tsuchizawa, Tai; Nishi, Hidetaka; Kou, Rai; Hiraki, Tatsurou; Takeda, Kotaro; Fukuda, Hiroshi; Ishikawa, Yasuhiko; Wada, Kazumi; Yamamoto, Tsuyoshi

2014-04-01

By way of a brief review of Si photonics technology, we show that significant improvements in device performance are necessary for practical telecommunications applications. In order to improve device performance in Si photonics, we have developed a Si-Ge-silica monolithic integration platform, on which compact Si-Ge-based modulators/detectors and silica-based high-performance wavelength filters are monolithically integrated. The platform features low-temperature silica film deposition, which cannot damage Si-Ge-based active devices. Using this platform, we have developed various integrated photonic devices for broadband telecommunications applications.

High-performance silicon photonics technology for telecommunications applications

PubMed Central

Yamada, Koji; Tsuchizawa, Tai; Nishi, Hidetaka; Kou, Rai; Hiraki, Tatsurou; Takeda, Kotaro; Fukuda, Hiroshi; Ishikawa, Yasuhiko; Wada, Kazumi; Yamamoto, Tsuyoshi

2014-01-01

By way of a brief review of Si photonics technology, we show that significant improvements in device performance are necessary for practical telecommunications applications. In order to improve device performance in Si photonics, we have developed a Si-Ge-silica monolithic integration platform, on which compact Si-Ge–based modulators/detectors and silica-based high-performance wavelength filters are monolithically integrated. The platform features low-temperature silica film deposition, which cannot damage Si-Ge–based active devices. Using this platform, we have developed various integrated photonic devices for broadband telecommunications applications. PMID:27877659

High-performance silicon photonics technology for telecommunications applications

NASA Astrophysics Data System (ADS)

Yamada, Koji; Tsuchizawa, Tai; Nishi, Hidetaka; Kou, Rai; Hiraki, Tatsurou; Takeda, Kotaro; Fukuda, Hiroshi; Ishikawa, Yasuhiko; Wada, Kazumi; Yamamoto, Tsuyoshi

2014-04-01

By way of a brief review of Si photonics technology, we show that significant improvements in device performance are necessary for practical telecommunications applications. In order to improve device performance in Si photonics, we have developed a Si-Ge-silica monolithic integration platform, on which compact Si-Ge-based modulators/detectors and silica-based high-performance wavelength filters are monolithically integrated. The platform features low-temperature silica film deposition, which cannot damage Si-Ge-based active devices. Using this platform, we have developed various integrated photonic devices for broadband telecommunications applications.

Project Integration Architecture: Inter-Application Propagation of Information

NASA Technical Reports Server (NTRS)

Jones, William Henry

2005-01-01

A principal goal of the Project Integration Architecture (PIA) is to facilitate the meaningful inter-application transfer of application-value-added information. Such exchanging applications may be largely unrelated to each other except through their applicability to an overall project; however, the PIA effort recognizes as fundamental the need to make such applications cooperate despite wide disparaties either in the fidelity of the analyses carried out, or even the disciplines of the analysis. This paper discusses the approach and techniques applied and anticipated by the PIA project in treating this need.

Integral equations in the study of polar and ionic interaction site fluids

PubMed Central

Howard, Jesse J.

2011-01-01

In this review article we consider some of the current integral equation approaches and application to model polar liquid mixtures. We consider the use of multidimensional integral equations and in particular progress on the theory and applications of three dimensional integral equations. The IEs we consider may be derived from equilibrium statistical mechanical expressions incorporating a classical Hamiltonian description of the system. We give example including salt solutions, inhomogeneous solutions and systems including proteins and nucleic acids. PMID:22383857

Design and Application of Integrated Assembly Technology of FRG in Residential Ceiling

NASA Astrophysics Data System (ADS)

Li, Xiuyun; Yu, Changyong

2018-06-01

FRG material is a new environmentally friendly indoor decoration materials and popular in prefabricated construction, the paper introduces the performance and design of materials, and takes FRG in the residential ceiling integrated assembly process into a demonstration project, which showed that FRG in the prefabricated modules integrated ceiling of the whole template scheme has a great artistry and application effect. Meanwhile it provides reference for the integrated ceiling assembly modular process design of similar indoor decoration.

Approximations first: a closer look at applications of the definite integral

NASA Astrophysics Data System (ADS)

Brandt, Keith

2017-01-01

I propose that students pay more attention to the approximations that lead to integral formulas when they study applications of the definite integral. The goal is to focus students on the underlying concepts and the definition of the definite integral - and to steer them away from memorizing formulas. To address this goal, I have written some computer-based activities that guide students through the nuts and bolts of the approximations that eventually lead to integral formulas. I describe the activities and suggest a few changes as to how we might approach this material.

Smart Power: New power integrated circuit technologies and their applications

NASA Astrophysics Data System (ADS)

Kuivalainen, Pekka; Pohjonen, Helena; Yli-Pietilae, Timo; Lenkkeri, Jaakko

1992-05-01

Power Integrated Circuits (PIC) is one of the most rapidly growing branches of the semiconductor technology. The PIC markets has been forecast to grow from 660 million dollars in 1990 to 1658 million dollars in 1994. It has even been forecast that at the end of the 1990's the PIC markets would correspond to the value of the whole semiconductor production in 1990. Automotive electronics will play the leading role in the development of the standard PIC's. Integrated motor drivers (36 V/4 A), smart integrated switches (60 V/30 A), solenoid drivers, integrated switch-mode power supplies and regulators are the latest standard devices of the PIC manufactures. ASIC (Application Specific Integrated Circuits) PIC solutions are needed for the same reasons as other ASIC devices: there are no proper standard devices, a company has a lot of application knowhow, which should be kept inside the company, the size of the product must be reduced, and assembly costs are wished to be reduced by decreasing the number of discrete devices. During the next few years the most probable ASIC PIC applications in Finland will be integrated solenoid and motor drivers, an integrated electronic lamp ballast circuit and various sensor interface circuits. Application of the PIC technologies to machines and actuators will strongly be increased all over the world. This means that various PIC's, either standard PIC's or full custom ASIC circuits, will appear in many products which compete with the corresponding Finnish products. Therefore the development of the PIC technologies must be followed carefully in order to immediately be able to apply the latest development in the smart power technologies and their design methods.

Development of Spreadsheet-Based Integrated Transaction Processing Systems and Financial Reporting Systems

NASA Astrophysics Data System (ADS)

Ariana, I. M.; Bagiada, I. M.

2018-01-01

Development of spreadsheet-based integrated transaction processing systems and financial reporting systems is intended to optimize the capabilities of spreadsheet in accounting data processing. The purpose of this study are: 1) to describe the spreadsheet-based integrated transaction processing systems and financial reporting systems; 2) to test its technical and operational feasibility. This study type is research and development. The main steps of study are: 1) needs analysis (need assessment); 2) developing spreadsheet-based integrated transaction processing systems and financial reporting systems; and 3) testing the feasibility of spreadsheet-based integrated transaction processing systems and financial reporting systems. The technical feasibility include the ability of hardware and operating systems to respond the application of accounting, simplicity and ease of use. Operational feasibility include the ability of users using accounting applications, the ability of accounting applications to produce information, and control applications of the accounting applications. The instrument used to assess the technical and operational feasibility of the systems is the expert perception questionnaire. The instrument uses 4 Likert scale, from 1 (strongly disagree) to 4 (strongly agree). Data were analyzed using percentage analysis by comparing the number of answers within one (1) item by the number of ideal answer within one (1) item. Spreadsheet-based integrated transaction processing systems and financial reporting systems integrate sales, purchases, and cash transaction processing systems to produce financial reports (statement of profit or loss and other comprehensive income, statement of changes in equity, statement of financial position, and statement of cash flows) and other reports. Spreadsheet-based integrated transaction processing systems and financial reporting systems is feasible from the technical aspects (87.50%) and operational aspects (84.17%).

32 CFR 158.4 - Policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... program management processes during applicable contingency operations. (2) Comply with applicable U.S..., “Policy and Procedures for Determining Workforce Mix.” (4) Fully consider, plan for, integrate, and execute acquisition of, contracted support, including synchronizing and integrating contracted support...

32 CFR 158.4 - Policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... program management processes during applicable contingency operations. (2) Comply with applicable U.S..., “Policy and Procedures for Determining Workforce Mix.” (4) Fully consider, plan for, integrate, and execute acquisition of, contracted support, including synchronizing and integrating contracted support...

32 CFR 158.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... program management processes during applicable contingency operations. (2) Comply with applicable U.S..., “Policy and Procedures for Determining Workforce Mix.” (4) Fully consider, plan for, integrate, and execute acquisition of, contracted support, including synchronizing and integrating contracted support...

Dynamic mobility application policy analysis : policy and institutional issues for Integrated Dynamic Transit Operations (IDTO).

DOT National Transportation Integrated Search

2015-07-01

This report documents policy considerations for Integrate Dynamic Transit (IDTO). IDTO applications provide individualized trip planning, transfer protection, and ridesharing options. The analysis identified the following potential policy issues: dat...

Monolithic silicon-photonic platforms in state-of-the-art CMOS SOI processes [Invited].

PubMed

Stojanović, Vladimir; Ram, Rajeev J; Popović, Milos; Lin, Sen; Moazeni, Sajjad; Wade, Mark; Sun, Chen; Alloatti, Luca; Atabaki, Amir; Pavanello, Fabio; Mehta, Nandish; Bhargava, Pavan

2018-05-14

Integrating photonics with advanced electronics leverages transistor performance, process fidelity and package integration, to enable a new class of systems-on-a-chip for a variety of applications ranging from computing and communications to sensing and imaging. Monolithic silicon photonics is a promising solution to meet the energy efficiency, sensitivity, and cost requirements of these applications. In this review paper, we take a comprehensive view of the performance of the silicon-photonic technologies developed to date for photonic interconnect applications. We also present the latest performance and results of our "zero-change" silicon photonics platforms in 45 nm and 32 nm SOI CMOS. The results indicate that the 45 nm and 32 nm processes provide a "sweet-spot" for adding photonic capability and enhancing integrated system applications beyond the Moore-scaling, while being able to offload major communication tasks from more deeply-scaled compute and memory chips without complicated 3D integration approaches.

Ceramic Integration Technologies for Advanced Energy Systems: Critical Needs, Technical Challenges, and Opportunities

NASA Technical Reports Server (NTRS)

Singh, Mrityunjay

2010-01-01

Advanced ceramic integration technologies dramatically impact the energy landscape due to wide scale application of ceramics in all aspects of alternative energy production, storage, distribution, conservation, and efficiency. Examples include fuel cells, thermoelectrics, photovoltaics, gas turbine propulsion systems, distribution and transmission systems based on superconductors, nuclear power generation and waste disposal. Ceramic integration technologies play a key role in fabrication and manufacturing of large and complex shaped parts with multifunctional properties. However, the development of robust and reliable integrated systems with optimum performance requires the understanding of many thermochemical and thermomechanical factors, particularly for high temperature applications. In this presentation, various needs, challenges, and opportunities in design, fabrication, and testing of integrated similar (ceramic ceramic) and dissimilar (ceramic metal) material www.nasa.gov 45 ceramic-ceramic-systems have been discussed. Experimental results for bonding and integration of SiC based Micro-Electro-Mechanical-Systems (MEMS) LDI fuel injector and advanced ceramics and composites for gas turbine applications are presented.

Medical Device Integrated Vital Signs Monitoring Application with Real-Time Clinical Decision Support.

PubMed

Moqeem, Aasia; Baig, Mirza; Gholamhosseini, Hamid; Mirza, Farhaan; Lindén, Maria

2018-01-01

This research involves the design and development of a novel Android smartphone application for real-time vital signs monitoring and decision support. The proposed application integrates market available, wireless and Bluetooth connected medical devices for collecting vital signs. The medical device data collected by the app includes heart rate, oxygen saturation and electrocardiograph (ECG). The collated data is streamed/displayed on the smartphone in real-time. This application was designed by adopting six screens approach (6S) mobile development framework and focused on user-centered approach and considered clinicians-as-a-user. The clinical engagement, consultations, feedback and usability of the application in the everyday practices were considered critical from the initial phase of the design and development. Furthermore, the proposed application is capable to deliver rich clinical decision support in real-time using the integrated medical device data.

Integrated nonlinear photonics. Emerging applications and ongoing challenges - A mini review

DOE PAGES

Hendrickson, Scott M.; Foster, Amy C.; Camacho, Ryan M.; ...

2014-11-26

In this paper, we provide a review of recent progress in integrated nonlinear photonics with a focus on emerging applications in all-optical signal processing, ultra-low-power all-optical switching, and quantum information processing.

Fronting Integrated Scientific Web Applications: Design Features and Benefits for Regulatory Environments

EPA Science Inventory

Integrated decision support systems for regulatory applications benefit from standardindustry practices such as code reuse, test-driven development, and modularization. Theseapproaches make meeting the federal government’s goals of transparency, efficiency, and quality assurance ...

Ground Operations Autonomous Control and Integrated Health Management

NASA Technical Reports Server (NTRS)

Daniels, James

2014-01-01

The Ground Operations Autonomous Control and Integrated Health Management plays a key role for future ground operations at NASA. The software that is integrated into this system is called G2 2011 Gensym. The purpose of this report is to describe the Ground Operations Autonomous Control and Integrated Health Management with the use of the G2 Gensym software and the G2 NASA toolkit for Integrated System Health Management (ISHM) which is a Computer Software Configuration Item (CSCI). The decision rationale for the use of the G2 platform is to develop a modular capability for ISHM and AC. Toolkit modules include knowledge bases that are generic and can be applied in any application domain module. That way, there's a maximization of reusability, maintainability, and systematic evolution, portability, and scalability. Engine modules are generic, while application modules represent the domain model of a specific application. Furthermore, the NASA toolkit, developed since 2006 (a set of modules), makes it possible to create application domain models quickly, using pre-defined objects that include sensors and components libraries for typical fluid, electrical, and mechanical systems.

Critical issues for the application of integrated MEMS/CMOS technologies to inertial measurement units

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, J.H.; Ellis, J.R.; Montague, S.

1997-03-01

One of the principal applications of monolithically integrated micromechanical/microelectronic systems has been accelerometers for automotive applications. As integrated MEMS/CMOS technologies such as those developed by U.C. Berkeley, Analog Devices, and Sandia National Laboratories mature, additional systems for more sensitive inertial measurements will enter the commercial marketplace. In this paper, the authors will examine key technology design rules which impact the performance and cost of inertial measurement devices manufactured in integrated MEMS/CMOS technologies. These design parameters include: (1) minimum MEMS feature size, (2) minimum CMOS feature size, (3) maximum MEMS linear dimension, (4) number of mechanical MEMS layers, (5) MEMS/CMOS spacing.more » In particular, the embedded approach to integration developed at Sandia will be examined in the context of these technology features. Presently, this technology offers MEMS feature sizes as small as 1 {micro}m, CMOS critical dimensions of 1.25 {micro}m, MEMS linear dimensions of 1,000 {micro}m, a single mechanical level of polysilicon, and a 100 {micro}m space between MEMS and CMOS. This is applicable to modern precision guided munitions.« less

Integration of image capture and processing: beyond single-chip digital camera

NASA Astrophysics Data System (ADS)

Lim, SukHwan; El Gamal, Abbas

2001-05-01

An important trend in the design of digital cameras is the integration of capture and processing onto a single CMOS chip. Although integrating the components of a digital camera system onto a single chip significantly reduces system size and power, it does not fully exploit the potential advantages of integration. We argue that a key advantage of integration is the ability to exploit the high speed imaging capability of CMOS image senor to enable new applications such as multiple capture for enhancing dynamic range and to improve the performance of existing applications such as optical flow estimation. Conventional digital cameras operate at low frame rates and it would be too costly, if not infeasible, to operate their chips at high frame rates. Integration solves this problem. The idea is to capture images at much higher frame rates than he standard frame rate, process the high frame rate data on chip, and output the video sequence and the application specific data at standard frame rate. This idea is applied to optical flow estimation, where significant performance improvements are demonstrate over methods using standard frame rate sequences. We then investigate the constraints on memory size and processing power that can be integrated with a CMOS image sensor in a 0.18 micrometers process and below. We show that enough memory and processing power can be integrated to be able to not only perform the functions of a conventional camera system but also to perform applications such as real time optical flow estimation.

A study of compositional verification based IMA integration method

NASA Astrophysics Data System (ADS)

Huang, Hui; Zhang, Guoquan; Xu, Wanmeng

2018-03-01

The rapid development of avionics systems is driving the application of integrated modular avionics (IMA) systems. But meanwhile it is improving avionics system integration, complexity of system test. Then we need simplify the method of IMA system test. The IMA system supports a module platform that runs multiple applications, and shares processing resources. Compared with federated avionics system, IMA system is difficult to isolate failure. Therefore, IMA system verification will face the critical problem is how to test shared resources of multiple application. For a simple avionics system, traditional test methods are easily realizing to test a whole system. But for a complex system, it is hard completed to totally test a huge and integrated avionics system. Then this paper provides using compositional-verification theory in IMA system test, so that reducing processes of test and improving efficiency, consequently economizing costs of IMA system integration.

Disposable photonic integrated circuits for evanescent wave sensors by ultra-high volume roll-to-roll method.

PubMed

Aikio, Sanna; Hiltunen, Jussi; Hiitola-Keinänen, Johanna; Hiltunen, Marianne; Kontturi, Ville; Siitonen, Samuli; Puustinen, Jarkko; Karioja, Pentti

2016-02-08

Flexible photonic integrated circuit technology is an emerging field expanding the usage possibilities of photonics, particularly in sensor applications, by enabling the realization of conformable devices and introduction of new alternative production methods. Here, we demonstrate that disposable polymeric photonic integrated circuit devices can be produced in lengths of hundreds of meters by ultra-high volume roll-to-roll methods on a flexible carrier. Attenuation properties of hundreds of individual devices were measured confirming that waveguides with good and repeatable performance were fabricated. We also demonstrate the applicability of the devices for the evanescent wave sensing of ambient refractive index. The production of integrated photonic devices using ultra-high volume fabrication, in a similar manner as paper is produced, may inherently expand methods of manufacturing low-cost disposable photonic integrated circuits for a wide range of sensor applications.

Project Integration Architecture: Application Architecture

NASA Technical Reports Server (NTRS)

Jones, William Henry

2005-01-01

The Project Integration Architecture (PIA) implements a flexible, object-oriented, wrapping architecture which encapsulates all of the information associated with engineering applications. The architecture allows the progress of a project to be tracked and documented in its entirety. Additionally, by bringing all of the information sources and sinks of a project into a single architectural space, the ability to transport information between those applications is enabled.

Defense AT and L. Volume 42, Number 1

DTIC Science & Technology

2013-02-01

Agnish The U.S. Army late last year began equipping brigade combat teams with its first package of radios, satellite systems, software applications...Army’s first package of radios, satellite systems, software applications, smartphone-like devices, and other network components that provide integrated... satellite communications, intelligence, mission command applications, and the integration of C4ISR equip- ment onto various vehicle platforms. This

Integrating the Visual Arts Back into the Classroom with Mobile Applications: Teaching beyond the "Click and View" Approach

ERIC Educational Resources Information Center

Katz-Buonincontro, Jen; Foster, Aroutis

2013-01-01

Teachers can use mobile applications to integrate the visual arts back into the classroom, but how? This article generates recommendations for selecting and using well-designed mobile applications in the visual arts beyond a "click and view " approach. Using quantitative content analysis, the results show the extent to which a sample of…

Web services as applications' integration tool: QikProp case study.

PubMed

Laoui, Abdel; Polyakov, Valery R

2011-07-15

Web services are a new technology that enables to integrate applications running on different platforms by using primarily XML to enable communication among different computers over the Internet. Large number of applications was designed as stand alone systems before the concept of Web services was introduced and it is a challenge to integrate them into larger computational networks. A generally applicable method of wrapping stand alone applications into Web services was developed and is described. To test the technology, it was applied to the QikProp for DOS (Windows). Although performance of the application did not change when it was delivered as a Web service, this form of deployment had offered several advantages like simplified and centralized maintenance, smaller number of licenses, and practically no training for the end user. Because by using the described approach almost any legacy application can be wrapped as a Web service, this form of delivery may be recommended as a global alternative to traditional deployment solutions. Copyright © 2011 Wiley Periodicals, Inc.

Integrated optics applied to astronomical aperture synthesis: general concept for space and ground based applications

NASA Astrophysics Data System (ADS)

Pierre, Kern; Malbet, Fabien; Berger, Jean Philippe; Rousselet-Perraut, Karine; Schanen, Isabelle; Nabias, Laurent; Benech, Pierre

2018-04-01

This paper, "Integrated optics applied to astronomical aperture synthesis: general concept for space and ground based applications," was presented as part of International Conference on Space Optics—ICSO 1997, held in Toulouse, France.

Topographic Science

USGS Publications Warehouse

Poppenga, Sandra K.; Evans, Gayla; Gesch, Dean; Stoker, Jason M.; Queija, Vivian R.; Worstell, Bruce; Tyler, Dean J.; Danielson, Jeff; Bliss, Norman; Greenlee, Susan

2010-01-01

The mission of U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center Topographic Science is to establish partnerships and conduct research and applications that facilitate the development and use of integrated national and global topographic datasets. Topographic Science includes a wide range of research and applications that result in improved seamless topographic datasets, advanced elevation technology, data integration and terrain visualization, new and improved elevation derivatives, and development of Web-based tools. In cooperation with our partners, Topographic Science is developing integrated-science applications for mapping, national natural resource initiatives, hazards, and global change science. http://topotools.cr.usgs.gov/.

Application of integration algorithms in a parallel processing environment for the simulation of jet engines

NASA Technical Reports Server (NTRS)

Krosel, S. M.; Milner, E. J.

1982-01-01

The application of Predictor corrector integration algorithms developed for the digital parallel processing environment are investigated. The algorithms are implemented and evaluated through the use of a software simulator which provides an approximate representation of the parallel processing hardware. Test cases which focus on the use of the algorithms are presented and a specific application using a linear model of a turbofan engine is considered. Results are presented showing the effects of integration step size and the number of processors on simulation accuracy. Real time performance, interprocessor communication, and algorithm startup are also discussed.

BIO-Plex Information System Concept

NASA Technical Reports Server (NTRS)

Jones, Harry; Boulanger, Richard; Arnold, James O. (Technical Monitor)

1999-01-01

This paper describes a suggested design for an integrated information system for the proposed BIO-Plex (Bioregenerative Planetary Life Support Systems Test Complex) at Johnson Space Center (JSC), including distributed control systems, central control, networks, database servers, personal computers and workstations, applications software, and external communications. The system will have an open commercial computing and networking, architecture. The network will provide automatic real-time transfer of information to database server computers which perform data collection and validation. This information system will support integrated, data sharing applications for everything, from system alarms to management summaries. Most existing complex process control systems have information gaps between the different real time subsystems, between these subsystems and central controller, between the central controller and system level planning and analysis application software, and between the system level applications and management overview reporting. An integrated information system is vitally necessary as the basis for the integration of planning, scheduling, modeling, monitoring, and control, which will allow improved monitoring and control based on timely, accurate and complete data. Data describing the system configuration and the real time processes can be collected, checked and reconciled, analyzed and stored in database servers that can be accessed by all applications. The required technology is available. The only opportunity to design a distributed, nonredundant, integrated system is before it is built. Retrofit is extremely difficult and costly.

Valuing the scholarship of integration and the scholarship of application in the academy for health sciences scholars: recommended methods

PubMed Central

Hofmeyer, Anne; Newton, Mandi; Scott, Cathie

2007-01-01

In the landmark 1990 publication Scholarship Reconsidered, Boyer challenged the 'teaching verses research debates' by advocating for the scholarship of discovery, teaching, integration, and application. The scholarship of discovery considers publications and research as the yardstick in the merit, promotion and tenure system the world over. But this narrow view of scholarship does not fully support the obligations of universities to serve global societies and to improve health and health equity. Mechanisms to report the scholarship of teaching have been developed and adopted by some universities. In this article, we contribute to the less developed areas of scholarship, i.e. integration and application. We firstly situate the scholarship of discovery, teaching, integration and application within the interprofessional and knowledge exchange debates. Second, we propose a means for health science scholars to report the process and outcomes of the scholarship of integration and application with other disciplines, decision-makers and communities. We conclude with recommendations for structural and process change in faculty merit, tenure, and promotion systems so that health science scholars with varied academic portfolios are valued and many forms of academic scholarship are sustained. It is vital academic institutions remain relevant in an era when the production of knowledge is increasingly recognized as a social collaborative activity. PMID:17535436

Service Management Database for DSN Equipment

NASA Technical Reports Server (NTRS)

Zendejas, Silvino; Bui, Tung; Bui, Bach; Malhotra, Shantanu; Chen, Fannie; Wolgast, Paul; Allen, Christopher; Luong, Ivy; Chang, George; Sadaqathulla, Syed

2009-01-01

This data- and event-driven persistent storage system leverages the use of commercial software provided by Oracle for portability, ease of maintenance, scalability, and ease of integration with embedded, client-server, and multi-tiered applications. In this role, the Service Management Database (SMDB) is a key component of the overall end-to-end process involved in the scheduling, preparation, and configuration of the Deep Space Network (DSN) equipment needed to perform the various telecommunication services the DSN provides to its customers worldwide. SMDB makes efficient use of triggers, stored procedures, queuing functions, e-mail capabilities, data management, and Java integration features provided by the Oracle relational database management system. SMDB uses a third normal form schema design that allows for simple data maintenance procedures and thin layers of integration with client applications. The software provides an integrated event logging system with ability to publish events to a JMS messaging system for synchronous and asynchronous delivery to subscribed applications. It provides a structured classification of events and application-level messages stored in database tables that are accessible by monitoring applications for real-time monitoring or for troubleshooting and analysis over historical archives.

Joining and Integration of Silicon Carbide-Based Materials for High Temperature Applications

NASA Technical Reports Server (NTRS)

Halbig, Michael C.; Singh, Mrityunjay

2016-01-01

Advanced joining and integration technologies of silicon carbide-based ceramics and ceramic matrix composites are enabling for their implementation into wide scale aerospace and ground-based applications. The robust joining and integration technologies allow for large and complex shapes to be fabricated and integrated with the larger system. Potential aerospace applications include lean-direct fuel injectors, thermal actuators, turbine vanes, blades, shrouds, combustor liners and other hot section components. Ground based applications include components for energy and environmental systems. Performance requirements and processing challenges are identified for the successful implementation different joining technologies. An overview will be provided of several joining approaches which have been developed for high temperature applications. In addition, various characterization approaches were pursued to provide an understanding of the processing-microstructure-property relationships. Microstructural analysis of the joint interfaces was conducted using optical, scanning electron, and transmission electron microscopy to identify phases and evaluate the bond quality. Mechanical testing results will be presented along with the need for new standardized test methods. The critical need for tailoring interlayer compositions for optimum joint properties will also be highlighted.

Path integral Monte Carlo ground state approach: formalism, implementation, and applications

NASA Astrophysics Data System (ADS)

Yan, Yangqian; Blume, D.

2017-11-01

Monte Carlo techniques have played an important role in understanding strongly correlated systems across many areas of physics, covering a wide range of energy and length scales. Among the many Monte Carlo methods applicable to quantum mechanical systems, the path integral Monte Carlo approach with its variants has been employed widely. Since semi-classical or classical approaches will not be discussed in this review, path integral based approaches can for our purposes be divided into two categories: approaches applicable to quantum mechanical systems at zero temperature and approaches applicable to quantum mechanical systems at finite temperature. While these two approaches are related to each other, the underlying formulation and aspects of the algorithm differ. This paper reviews the path integral Monte Carlo ground state (PIGS) approach, which solves the time-independent Schrödinger equation. Specifically, the PIGS approach allows for the determination of expectation values with respect to eigen states of the few- or many-body Schrödinger equation provided the system Hamiltonian is known. The theoretical framework behind the PIGS algorithm, implementation details, and sample applications for fermionic systems are presented.

A universal data access and protocol integration mechanism for smart home

NASA Astrophysics Data System (ADS)

Shao, Pengfei; Yang, Qi; Zhang, Xuan

2013-03-01

With the lack of standardized or completely missing communication interfaces in home electronics, there is no perfect solution to address every aspect in smart homes based on existing protocols and technologies. In addition, the central control unit (CCU) of smart home system working point-to-point between the multiple application interfaces and the underlying hardware interfaces leads to its complicated architecture and unpleasant performance. A flexible data access and protocol integration mechanism is required. The current paper offers a universal, comprehensive data access and protocol integration mechanism for a smart home. The universal mechanism works as a middleware adapter with unified agreements of the communication interfaces and protocols, offers an abstraction of the application level from the hardware specific and decoupling the hardware interface modules from the application level. Further abstraction for the application interfaces and the underlying hardware interfaces are executed based on adaption layer to provide unified interfaces for more flexible user applications and hardware protocol integration. This new universal mechanism fundamentally changes the architecture of the smart home and in some way meets the practical requirement of smart homes more flexible and desirable.

Avionics systems integration technology

NASA Technical Reports Server (NTRS)

Stech, George; Williams, James R.

1988-01-01

A very dramatic and continuing explosion in digital electronics technology has been taking place in the last decade. The prudent and timely application of this technology will provide Army aviation the capability to prevail against a numerically superior enemy threat. The Army and NASA have exploited this technology explosion in the development and application of avionics systems integration technology for new and future aviation systems. A few selected Army avionics integration technology base efforts are discussed. Also discussed is the Avionics Integration Research Laboratory (AIRLAB) that NASA has established at Langley for research into the integration and validation of avionics systems, and evaluation of advanced technology in a total systems context.

Development and application of a local linearization algorithm for the integration of quaternion rate equations in real-time flight simulation problems

NASA Technical Reports Server (NTRS)

Barker, L. E., Jr.; Bowles, R. L.; Williams, L. H.

1973-01-01

High angular rates encountered in real-time flight simulation problems may require a more stable and accurate integration method than the classical methods normally used. A study was made to develop a general local linearization procedure of integrating dynamic system equations when using a digital computer in real-time. The procedure is specifically applied to the integration of the quaternion rate equations. For this application, results are compared to a classical second-order method. The local linearization approach is shown to have desirable stability characteristics and gives significant improvement in accuracy over the classical second-order integration methods.

Description of the population structure and genetic diversity of tuberculosis in Estado de México, a low prevalence setting from Mexico.

PubMed

Zenteno-Cuevas, Roberto; Mendoza-Damián, Fabiola; Muñoz, Irving Cansino; Enciso-Moreno, Leonor; Pérez-Navarro, Lucia Monserrat; Ramírez-Hernández, Ma Dolores; Vázquez-Medina, Karen; Widrobo-García, Lorena; Lauzardo, Michael; Enciso-Moreno, José Antonio

2015-02-01

In order to identify the genetic characteristics of the strains of mycobacteria circulating in the Estado de México, one of the states with the lowest prevalence of tuberculosis in Mexico, spoligotyping and 12-loci MIRU-VNTR typing were used to genotype tuberculosis clinical isolates. The average age of the 183 patients analyzed was 50 (± 17) years, drug resistance was noted in 57 (31%) and multidrug resistance in 22 (12%) individuals. The results from the isolates recovered showed that 80% were located in four major Euro-American lineages: Haarlem (17%), LAM (15%), T (20%) and X (29%). Other lineages found in lower proportions were: EAI, S, Beijing, West African, Turkey, Vole and Bovis. Eighteen isolates were orphans. Only 57 isolates were grouped in nine clusters and the SIT119 (X1) showed the highest number of members (23). The LAM lineage showed an increased risk for development of drug resistance (RR=4, IC: 95%: 1.05-14.2, p = 0.03). Despite the important prevalence of four major lineages found and the diversity of strains circulating in the population, we found the presence of one of the largest populations of isolates clustered to the X lineage in a setting from a Latin American country. © 2014 APMIS. Published by John Wiley & Sons Ltd.

Analog simulation of a hybrid gasoline-electric vehicle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilmore, D.B.

1982-03-01

Hybrid vehicles using both internal combustion engines and electric motors represent one way to reduce fuel consumption. Our demonstration project envisioned more than halving the fuel consumption of a passenger vehicle by reducing greatly the capacity of its engine and adding regenerative braking and an all-electric range. We also envisaged maintaining the same performance as current passenger vehicles. A 0-6 000 rpm gasoline-driven internal combustion engine, two 0-7 800 rpm electric motors, a 0-7 800 rpm flywheel, and lead-acid batteries are the major components assembled using a mechnical epicyclic gear box. An EAI 681 analog computer allowed us to examinemore » quickly the effects of engine capacity, flywheel size, battery voltage, gear ratios, and mode of operation. An external potentiometer control on the computer allowed the operator to drive the vehicle through any acceleration cycle on level ground. We have shown that a 1.3 litre gasoline engine, two 13 kW separately excited direct current electric motors, a 38 kg flywheel, and a 48-volt battery pack will provide the same maximum performance as a conventional 4.1 litre internal combustion engine with automatic transmission at vehicle speeds below 60 km/h, and lower but satisfactory highway performance up to a top speed of 130 km/h. The transmission has undergone laboratory tests; it is to be road-tested in the first half of 1982.« less

A Palaeohydrological Shift during Neogene East Antarctic Ice Sheet Retreat

NASA Astrophysics Data System (ADS)

Rees-Owen, R. L.; Newton, R.; Ivanovic, R. F.; Francis, J.; Tindall, J. C.; Riding, J. B.

2015-12-01

The East Antarctic Ice Sheet is an important driver of global climate, playing a particular role in governing albedo and atmospheric circulation (eg. Singh et al., 2013). Recent evidence from marine sediment and terrestrial glaciovolcanic sequences suggests that the EAIS underwent periodic retreat and collapse in response to warmer climates during the late Neogene (14 to 3 million years ago). Mummified prostrate trees recovered from palaeosols at Oliver Bluffs in the Beardmore Glacier region, Transantarctic Mountains (85° S), represent a rare insight into the terrestrial palaeoclimate during one of these periods of retreat. Prostrate trees are an understudied but useful tool for interrogating endmember (e.g. periglacial) environments at high altitudes and latitudes. We present exciting new palaeoclimate data from the sequence at Oliver Bluffs. δ18O analysis of tree ring cellulose suggests that Antarctic summer palaeoprecipitation was enriched relative to today (-25 to -5‰ for ancient, -35 to -20‰ for modern); consistent with our isotope-enabled general circulation model simulations. The MBT/CBT palaeothermometer gives a summer temperature of 3-6ºC, consistent with other palaeobotanical climate indices. These geological and model data have wide-ranging implications for our understanding of the hydrological cycle during this time period. We present data suggesting that changes in moisture recycling and source region indicate a markedly different hydrological cycle.

Lead sulfide - Silicon MOSFET infrared focal plane development

NASA Technical Reports Server (NTRS)

Barrett, J. R.; Jhabvala, M. D.

1983-01-01

A process for directly integrating photoconductive lead sulfide (PbS) infrared detector material with silicon MOS integrated circuits has been developed primarily for application in long (greater than 10,000 detector elements) linear arrays for pushbroom scanning applications. The processing technology is based on the conventional PMOS and CMOS technologies with a variation in the metallization. Results and measurements on a fully integrated eight-element multiplexer are shown.

FloorspaceJS - A New, Open Source, Web-Based Geometry Editor for Building Energy Modeling (BEM): Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Macumber, Daniel L; Horowitz, Scott G; Schott, Marjorie

Across most industries, desktop applications are being rapidly migrated to web applications for a variety of reasons. Web applications are inherently cross platform, mobile, and easier to distribute than desktop applications. Fueling this trend are a wide range of free, open source libraries and frameworks that make it incredibly easy to develop powerful web applications. The building energy modeling community is just beginning to pick up on these larger trends, with a small but growing number of building energy modeling applications starting on or moving to the web. This paper presents a new, open source, web based geometry editor formore » Building Energy Modeling (BEM). The editor is written completely in JavaScript and runs in a modern web browser. The editor works on a custom JSON file format and is designed to be integrated into a variety of web and desktop applications. The web based editor is available to use as a standalone web application at: https://nrel.github.io/openstudio-geometry-editor/. An example integration is demonstrated with the OpenStudio desktop application. Finally, the editor can be easily integrated with a wide range of possible building energy modeling web applications.« less

Striding through Time

ERIC Educational Resources Information Center

Clary, Renee; Wandersee, James

2014-01-01

The "Next Generation Science Standards" (NGSS) focus attention on integrating engineering and math in science instruction. The dinosaur trackway project described in this article shows that it is possible to assign engineering applications to students in disciplines other than physics and to integrate math and engineering applications in…

Novel Three-Dimensional Vertical Interconnect Technology for Microwave and RF Applications

NASA Technical Reports Server (NTRS)

Goverdhanam, Kavita; Simons, Rainee N.; Katehi, Linda P. B.

1999-01-01

In this paper, novel 3D interconnects suitable for applications in microwave and RF integrated circuit technology have been presented. The interconnect fabrication process and design details are presented. In addition, measured and numerically modeled results of the performance of the interconnects have been shown. The results indicate that the proposed technology has tremendous potential applications in integrated circuit technology. C,

Asymptotic integration algorithms for first-order ODEs with application to viscoplasticity

NASA Technical Reports Server (NTRS)

Freed, Alan D.; Yao, Minwu; Walker, Kevin P.

1992-01-01

When constructing an algorithm for the numerical integration of a differential equation, one must first convert the known ordinary differential equation (ODE), which is defined at a point, into an ordinary difference equation (O(delta)E), which is defined over an interval. Asymptotic, generalized, midpoint, and trapezoidal, O(delta)E algorithms are derived for a nonlinear first order ODE written in the form of a linear ODE. The asymptotic forward (typically underdamped) and backward (typically overdamped) integrators bound these midpoint and trapezoidal integrators, which tend to cancel out unwanted numerical damping by averaging, in some sense, the forward and backward integrations. Viscoplasticity presents itself as a system of nonlinear, coupled first-ordered ODE's that are mathematically stiff, and therefore, difficult to numerically integrate. They are an excellent application for the asymptotic integrators. Considering a general viscoplastic structure, it is demonstrated that one can either integrate the viscoplastic stresses or their associated eigenstrains.

Integrated Approaches On Archaeo-Geophysical Data

NASA Astrophysics Data System (ADS)

Kucukdemirci, M.; Piro, S.; Zamuner, D.; Ozer, E.

2015-12-01

Key words: Ground Penetrating Radar (GPR), Magnetometry, Geophysical Data Integration, Principal Component Analyse (PCA), Aizanoi Archaeological Site An application of geophysical integration methods which often appealed are divided into two classes as qualitative and quantitative approaches. This work focused on the application of quantitative integration approaches, which involve the mathematical and statistical integration techniques, on the archaeo-geophysical data obtained in Aizanoi Archaeological Site,Turkey. Two geophysical methods were applied as Ground Penetrating Radar (GPR) and Magnetometry for archaeological prospection on the selected archaeological site. After basic data processing of each geophysical method, the mathematical approaches of Sums and Products and the statistical approach of Principal Component Analysis (PCA) have been applied for the integration. These integration approches were first tested on synthetic digital images before application to field data. Then the same approaches were applied to 2D magnetic maps and 2D GPR time slices which were obtained on the same unit grids in the archaeological site. Initially, the geophysical data were examined individually by referencing with archeological maps and informations obtained from archaeologists and some important structures as possible walls, roads and relics were determined. The results of all integration approaches provided very important and different details about the anomalies related to archaeological features. By using all those applications, integrated images can provide complementary informations as well about the archaeological relics under the ground. Acknowledgements The authors would like to thanks to Scientific and Technological Research Council of Turkey (TUBITAK), Fellowship for Visiting Scientists Programme for their support, Istanbul University Scientific Research Project Fund, (Project.No:12302) and archaeologist team of Aizanoi Archaeological site for their support during the field work.

Integration of electrochemistry in micro-total analysis systems for biochemical assays: recent developments.

PubMed

Xu, Xiaoli; Zhang, Song; Chen, Hui; Kong, Jilie

2009-11-15

Micro-total analysis systems (microTAS) integrate different analytical operations like sample preparation, separation and detection into a single microfabricated device. With the outstanding advantages of low cost, satisfactory analytical efficiency and flexibility in design, highly integrated and miniaturized devices from the concept of microTAS have gained widespread applications, especially in biochemical assays. Electrochemistry is shown to be quite compatible with microanalytical systems for biochemical assays, because of its attractive merits such as simplicity, rapidity, high sensitivity, reduced power consumption, and sample/reagent economy. This review presents recent developments in the integration of electrochemistry in microdevices for biochemical assays. Ingenious microelectrode design and fabrication methods, and versatility of electrochemical techniques are involved. Practical applications of such integrated microsystem in biochemical assays are focused on in situ analysis, point-of-care testing and portable devices. Electrochemical techniques are apparently suited to microsystems, since easy microfabrication of electrochemical elements and a high degree of integration with multi-analytical functions can be achieved at low cost. Such integrated microsystems will play an increasingly important role for analysis of small volume biochemical samples. Work is in progress toward new microdevice design and applications.

Application of the Sumudu Transform to Discrete Dynamic Systems

ERIC Educational Resources Information Center

Asiru, Muniru Aderemi

2003-01-01

The Sumudu transform is an integral transform introduced to solve differential equations and control engineering problems. The transform possesses many interesting properties that make visualization easier and application has been demonstrated in the solution of partial differential equations, integral equations, integro-differential equations and…

An Integrated Approach to Teaching Biochemistry for Pharmacy Students.

ERIC Educational Resources Information Center

Poirier, Therese I.; Borke, Mitchell L.

1982-01-01

A Duquesne course integrating biochemistry lectures, clinical applications lectures, and laboratory sessions has the objectives of (1) making the course more relevant to students' perceived needs; (2) enhancing the learning process; (3) introducing clinical applications early in the students' program; and (4) demonstrating additional…

Application of intelligent sensors in the integrated systems health monitoring of a rocket test stand

NASA Astrophysics Data System (ADS)

Mahajan, Ajay; Chitikeshi, Sanjeevi; Utterbach, Lucas; Bandhil, Pavan; Figueroa, Fernando

2006-05-01

This paper describes the application of intelligent sensors in the Integrated Systems Health Monitoring (ISHM) as applied to a rocket test stand. The development of intelligent sensors is attempted as an integrated system approach, i.e. one treats the sensors as a complete system with its own physical transducer, A/D converters, processing and storage capabilities, software drivers, self-assessment algorithms, communication protocols and evolutionary methodologies that allow them to get better with time. Under a project being undertaken at the NASA Stennis Space Center, an integrated framework is being developed for the intelligent monitoring of smart elements associated with the rocket tests stands. These smart elements can be sensors, actuators or other devices. Though the immediate application is the monitoring of the rocket test stands, the technology should be generally applicable to the ISHM vision. This paper outlines progress made in the development of intelligent sensors by describing the work done till date on Physical Intelligent sensors (PIS) and Virtual Intelligent Sensors (VIS).

STRS Radio Service Software for NASA's SCaN Testbed

NASA Technical Reports Server (NTRS)

Mortensen, Dale J.; Bishop, Daniel Wayne; Chelmins, David T.

2012-01-01

NASAs Space Communication and Navigation(SCaN) Testbed was launched to the International Space Station in 2012. The objective is to promote new software defined radio technologies and associated software application reuse, enabled by this first flight of NASAs Space Telecommunications Radio System(STRS) architecture standard. Pre-launch testing with the testbeds software defined radios was performed as part of system integration. Radio services for the JPL SDR were developed during system integration to allow the waveform application to operate properly in the space environment, especially considering thermal effects. These services include receiver gain control, frequency offset, IQ modulator balance, and transmit level control. Development, integration, and environmental testing of the radio services will be described. The added software allows the waveform application to operate properly in the space environment, and can be reused by future experimenters testing different waveform applications. Integrating such services with the platform provided STRS operating environment will attract more users, and these services are candidates for interface standardization via STRS.

STRS Radio Service Software for NASA's SCaN Testbed

NASA Technical Reports Server (NTRS)

Mortensen, Dale J.; Bishop, Daniel Wayne; Chelmins, David T.

2013-01-01

NASA's Space Communication and Navigation(SCaN) Testbed was launched to the International Space Station in 2012. The objective is to promote new software defined radio technologies and associated software application reuse, enabled by this first flight of NASA's Space Telecommunications Radio System (STRS) architecture standard. Pre-launch testing with the testbed's software defined radios was performed as part of system integration. Radio services for the JPL SDR were developed during system integration to allow the waveform application to operate properly in the space environment, especially considering thermal effects. These services include receiver gain control, frequency offset, IQ modulator balance, and transmit level control. Development, integration, and environmental testing of the radio services will be described. The added software allows the waveform application to operate properly in the space environment, and can be reused by future experimenters testing different waveform applications. Integrating such services with the platform provided STRS operating environment will attract more users, and these services are candidates for interface standardization via STRS.

MEMS Technology for Space Applications

NASA Technical Reports Server (NTRS)

vandenBerg, A.; Spiering, V. L.; Lammerink, T. S. J.; Elwenspoek, M.; Bergveld, P.

1995-01-01

Micro-technology enables the manufacturing of all kinds of components for miniature systems or micro-systems, such as sensors, pumps, valves, and channels. The integration of these components into a micro-electro-mechanical system (MEMS) drastically decreases the total system volume and mass. These properties, combined with the increasing need for monitoring and control of small flows in (bio)chemical experiments, makes MEMS attractive for space applications. The level of integration and applied technology depends on the product demands and the market. The ultimate integration is process integration, which results in a one-chip system. An example of process integration is a dosing system of pump, flow sensor, micromixer, and hybrid feedback electronics to regulate the flow. However, for many applications, a hybrid integration of components is sufficient and offers the advantages of design flexibility and even the exchange of components in the case of a modular set up. Currently, we are working on hybrid integration of all kinds of sensors (physical and chemical) and flow system modules towards a modular system; the micro total analysis system (micro TAS). The substrate contains electrical connections as in a printed circuit board (PCB) as well as fluid channels for a circuit channel board (CCB) which, when integrated, form a mixed circuit board (MCB).

Guidelines for NASA Missions to Engage the User Community as a Part of the Mission Life Cycle

NASA Astrophysics Data System (ADS)

Escobar, V. M.; Friedl, L.; Bonniksen, C. K.

2017-12-01

NASA continues to improve the Earth Science Directorate in the areas of thematic integration, stakeholder feedback and Project Applications Program tailoring for missions to transfer knowledge between scientists and projects. The integration of application themes and the implementation of application science activities in flight projects have evolved to formally include user feedback and stakeholder integration. NASA's new Flight Applied Science Program Guidelines are designed to bridge NASA Earth Science Directorates in Flight, Applied Sciences and Research and Development by agreeing to integrate the user community into mission life cycles. Thus science development and science applications will guide all new instruments launched by NASAs ESD. The continued integration with the user community has enabled socio-economic considerations into NASA Earth Science projects to advance significantly. Making users a natural part of mission science leverages future socio-economic impact research and provides a platform for innovative and more actionable product to be used in decision support systems by society. This presentation will give an overview of the new NASA Guidelines and provide samples that demonstrate how the user community can be a part of NASA mission designs.

Developing the Fundamental Theorem of Calculus. Applications of Calculus to Work, Area, and Distance Problems. [and] Atmospheric Pressure in Relation to Height and Temperature. Applications of Calculus to Atmospheric Pressure. [and] The Gradient and Some of Its Applications. Applications of Multivariate Calculus to Physics. [and] Kepler's Laws and the Inverse Square Law. Applications of Calculus to Physics. UMAP Units 323, 426, 431, 473.

ERIC Educational Resources Information Center

Lindstrom, Peter A.; And Others

This document consists of four units. The first of these views calculus applications to work, area, and distance problems. It is designed to help students gain experience in: 1) computing limits of Riemann sums; 2) computing definite integrals; and 3) solving elementary area, distance, and work problems by integration. The second module views…

Project Integration Architecture: A Practical Demonstration of Information Propagation

NASA Technical Reports Server (NTRS)

Jones, William Henry

2005-01-01

One of the goals of the Project Integration Architecture (PIA) effort is to provide the ability to propagate information between disparate applications. With this ability, applications may then be formed into an application graph constituting a super-application. Such a super-application would then provide all of the analysis appropriate to a given technical system. This paper reports on a small demonstration of this concept in which a Computer Aided Design (CAD) application was connected to an inlet analysis code and geometry information automatically propagated from one to the other. The majority of the work reported involved not the technology of information propagation, but rather the conversion of propagated information into a form usable by the receiving application.

The first teleautomatic low-voltage prosthesis with multiple therapeutic applications: a new version of the German artificial sphincter system.

PubMed

Ruthmann, Olaf; Richter, Sabine; Seifert, Gabriel; Karcz, Wojciech; Goldschmidboing, Frank; Lemke, Thomas; Biancuzzi, Gionvanni; Woias, Peter; Schmidt, Thomas; Schwarzbqch, Stefan; Vodermayer, Bernahard; Hopt, Ulrich; Schrag, Hans-Jurgen

2010-08-01

To date, there are no artificial sphincter prostheses for urinary or fecal incontinence that may be implemented elsewhere instead, for example, in the upper gastrointestinal tract. Conventional systems are conceptually similar but are constructed specifically for distinct applications and are manual in operation. The German Artificial Sphincter System (GASS) II is the evolution of a highly integrative, modular, telemetric sphincter prosthesis with more than one application. Redesigning and integrating multilayer actuators into the pump allows us to reduce the input voltage to -10 to +20 V (V(PP) = 30 V). This provides for a flow rate of 2.23 mL/min and a counterpressure stability of 260 mbar. Furthermore, multiple applications have become feasible due to our standardized connection system, therapy-specific compression units, and application-specific software. These innovations allow us to integrate not only severe fecal and urinary incontinence, erectile dysfunction, and therapy-resistant reflux disease, but also morbid adiposity into the gamut of therapeutic GASS applications.

Robopedia: Leveraging Sensorpedia for Web-Enabled Robot Control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Resseguie, David R

There is a growing interest in building Internetscale sensor networks that integrate sensors from around the world into a single unified system. In contrast, robotics application development has primarily focused on building specialized systems. These specialized systems take scalability and reliability into consideration, but generally neglect exploring the key components required to build a large scale system. Integrating robotic applications with Internet-scale sensor networks will unify specialized robotics applications and provide answers to large scale implementation concerns. We focus on utilizing Internet-scale sensor network technology to construct a framework for unifying robotic systems. Our framework web-enables a surveillance robot smore » sensor observations and provides a webinterface to the robot s actuators. This lets robots seamlessly integrate into web applications. In addition, the framework eliminates most prerequisite robotics knowledge, allowing for the creation of general web-based robotics applications. The framework also provides mechanisms to create applications that can interface with any robot. Frameworks such as this one are key to solving large scale mobile robotics implementation problems. We provide an overview of previous Internetscale sensor networks, Sensorpedia (an ad-hoc Internet-scale sensor network), our framework for integrating robots with Sensorpedia, two applications which illustrate our frameworks ability to support general web-based robotic control, and offer experimental results that illustrate our framework s scalability, feasibility, and resource requirements.« less

Fault tolerance analysis and applications to microwave modules and MMIC's

NASA Astrophysics Data System (ADS)

Boggan, Garry H.

A project whose objective was to provide an overview of built-in-test (BIT) considerations applicable to microwave systems, modules, and MMICs (monolithic microwave integrated circuits) is discussed. Available analytical techniques and software for assessing system failure characteristics were researched, and the resulting investigation provides a review of two techniques which have applicability to microwave systems design. A system-level approach to fault tolerance and redundancy management is presented in its relationship to the subsystem/element design. An overview of the microwave BIT focus from the Air Force Integrated Diagnostics program is presented. The technical reports prepared by the GIMADS team were reviewed for applicability to microwave modules and components. A review of MIMIC (millimeter and microwave integrated circuit) program activities relative to BIT/BITE is given.

Dynamic Mobility Applications Policy Analysis: Policy and Institutional Issues for Integrated Dynamic Transit Operations (IDTO). [supporting datasets

DOT National Transportation Integrated Search

2015-01-27

The datasets in this zip file are in support of Intelligent Transportation Systems Joint Program Office (ITS JPO) report FHWA-JPO-14-134, "Dynamic Mobility Applications Policy Analysis: Policy and Institutional Issues for Integrated Dynamic Transit O...

Systematic Review: Concept and Tool Development with Application in the Integrated Risk Information System (IRIS) Assessment Process

EPA Science Inventory

Systematic Review: Concept and tool development with application to the National Toxicology Program (NTP) and the Integrated Risk Information System (IRIS) Assessment Processes. There is growing interest within the environmental health community to incorporate systematic review m...

Integration of Optimal Scheduling with Case-Based Planning.

DTIC Science & Technology

1995-08-01

integrates Case-Based Reasoning (CBR) and Rule-Based Reasoning (RBR) systems. ’ Tachyon : A Constraint-Based Temporal Reasoning Model and Its...Implementation’ provides an overview of the Tachyon temporal’s reasoning system and discusses its possible applications. ’Dual-Use Applications of Tachyon : From...Force Structure Modeling to Manufacturing Scheduling’ discusses the application of Tachyon to real world problems, specifically military force deployment and manufacturing scheduling.

Institute of Navigation Satellite Division, International Technical Meeting, 2nd, Colorado Springs, CO, Sept. 27-29, 1989, Proceedings

NASA Astrophysics Data System (ADS)

Various papers on navigation satellites are presented. The general topics considered include: overview and status of GPS, kinematic positioning, international developments and perspective on satellite positioning, test range applications, civil applications, and receiver developments and equipment. Consideration is given to multisensor integration, military applications, differential operation, integrity, propagation phenomena and measurement networks, and precise time and time transfer.

Earth Science and Applications attached payloads on Space Station

NASA Technical Reports Server (NTRS)

Wicks, Thomas G.; Arnold, Ralph R.

1990-01-01

This paper describes the Office of Space Science and Applications' process for Attached Payloads on Space Station Freedom from development through on-orbit operations. Its primary objectives are to detail the sequential steps of the attached payload methodology by tracing in particular the selected Earth Science and Applications' payloads through this flow and relate the integral role of Marshall Space Flight Center's Science Utilization Management function of integration and operations.

[Modern research progress of traditional Chinese medicine based on integrative pharmacology].

PubMed

Wang, Ping; Tang, Shi-Huan; Su, Jin; Zhang, Jia-Qi; Cui, Ru-Yi; Xu, Hai-Yu; Yang, Hong-Jun

2018-04-01

Integrative pharmacology (IP) is a discipline that studies the interaction, integration and principle of action of multiple components with the body, emphasizing the integrations of multi-level and multi-link, such as "whole and part", " in vivo and in vitro ", " in vivo process and activity evaluation". After four years of development and practice, the theory and method of IP has received extensive attention and application.In order to better promote the development of IP, this paper systematically reviews the concepts, research contents, research methods and application fields about IP. Copyright© by the Chinese Pharmaceutical Association.

The Environment for Application Software Integration and Execution (EASIE) version 1.0. Volume 1: Executive overview

NASA Technical Reports Server (NTRS)

Rowell, Lawrence F.; Davis, John S.

1989-01-01

The Environment for Application Software Integration and Execution (EASIE) provides a methodology and a set of software utility programs to ease the task of coordinating engineering design and analysis codes. EASIE was designed to meet the needs of conceptual design engineers that face the task of integrating many stand-alone engineering analysis programs. Using EASIE, programs are integrated through a relational database management system. Volume 1, Executive Overview, gives an overview of the functions provided by EASIE and describes their use. Three operational design systems based upon the EASIE software are briefly described.

Dynamic integral imaging technology for 3D applications (Conference Presentation)

NASA Astrophysics Data System (ADS)

Huang, Yi-Pai; Javidi, Bahram; Martínez-Corral, Manuel; Shieh, Han-Ping D.; Jen, Tai-Hsiang; Hsieh, Po-Yuan; Hassanfiroozi, Amir

2017-05-01

Depth and resolution are always the trade-off in integral imaging technology. With the dynamic adjustable devices, the two factors of integral imaging can be fully compensated with time-multiplexed addressing. Those dynamic devices can be mechanical or electrical driven. In this presentation, we will mainly focused on discussing various Liquid Crystal devices which can change the focal length, scan and shift the image position, or switched in between 2D/3D mode. By using the Liquid Crystal devices, dynamic integral imaging have been successfully applied on 3D Display, capturing, and bio-imaging applications.

Hybrid Integrated Platforms for Silicon Photonics

PubMed Central

Liang, Di; Roelkens, Gunther; Baets, Roel; Bowers, John E.

2010-01-01

A review of recent progress in hybrid integrated platforms for silicon photonics is presented. Integration of III-V semiconductors onto silicon-on-insulator substrates based on two different bonding techniques is compared, one comprising only inorganic materials, the other technique using an organic bonding agent. Issues such as bonding process and mechanism, bonding strength, uniformity, wafer surface requirement, and stress distribution are studied in detail. The application in silicon photonics to realize high-performance active and passive photonic devices on low-cost silicon wafers is discussed. Hybrid integration is believed to be a promising technology in a variety of applications of silicon photonics.

Integrating DXplain into a clinical information system using the World Wide Web.

PubMed

Elhanan, G; Socratous, S A; Cimino, J J

1996-01-01

The World Wide Web(WWW) offers a cross-platform environment and standard protocols that enable integration of various applications available on the Internet. The authors use the Web to facilitate interaction between their Web-based Clinical Information System and a decision-support system-DXplain, at the Massachusetts General Hospital-using local architecture and Common Gateway Interface programs. The current application translates patients laboratory test results into DXplain's terms to generate diagnostic hypotheses. Two different access methods are utilized for this model; Hypertext Transfer Protocol (HTTP) and TCP/IP function calls. While clinical aspects cannot be evaluated as yet, the model demonstrates the potential of Web-based applications for interaction and integration and how local architecture, with a controlled vocabulary server, can further facilitate such integration. This model serves to demonstrate some of the limitations of the current WWW technology and identifies issues such as control over Web resources and their utilization and liability issues as possible obstacles for further integration.

Photonics-on-a-chip: recent advances in integrated waveguides as enabling detection elements for real-world, lab-on-a-chip biosensing applications.

PubMed

Washburn, Adam L; Bailey, Ryan C

2011-01-21

By leveraging advances in semiconductor microfabrication technologies, chip-integrated optical biosensors are poised to make an impact as scalable and multiplexable bioanalytical measurement tools for lab-on-a-chip applications. In particular, waveguide-based optical sensing technology appears to be exceptionally amenable to chip integration and miniaturization, and, as a result, the recent literature is replete with examples of chip-integrated waveguide sensing platforms developed to address a wide range of contemporary analytical challenges. As an overview of the most recent advances within this dynamic field, this review highlights work from the last 2-3 years in the areas of grating-coupled, interferometric, photonic crystal, and microresonator waveguide sensors. With a focus towards device integration, particular emphasis is placed on demonstrations of biosensing using these technologies within microfluidically controlled environments. In addition, examples of multiplexed detection and sensing within complex matrices--important features for real-world applicability--are given special attention.

Operations system administration plan for HANDI 2000 business management system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, D.E.

The Hanford Data Integration 2000 (HANDI 2000) Project will result in an integrated and comprehensive set of functional applications containing core information necessary to support the Project Hanford Management Contract (PHMC). It is based on the Commercial-Off-The-Shelf (COTS) product solution with commercially proven business processes. This includes systems that support finance, supply, chemical management, human resources and payroll activities on the Hanford Site. The Passport (PP) software is an integrated application for Accounts Payable, Contract Management, Inventory Management, Purchasing, and Material Safety Data Sheets (MSDS). The PeopleSoft (PS) software is an integrated application for General Ledger, Project Costing, Human Resources,more » Payroll, Benefits, and Training. The implementation of this set of products, as the first deliverable of the HANDI 2000 Project, is referred to as Business Management System (BMS) and MSDS.« less

Military and Government Applications of Human-Machine Communication by Voice

NASA Astrophysics Data System (ADS)

Weinstein, Clifford J.

1995-10-01

This paper describes a range of opportunities for military and government applications of human-machine communication by voice, based on visits and contacts with numerous user organizations in the United States. The applications include some that appear to be feasible by careful integration of current state-of-the-art technology and others that will require a varying mix of advances in speech technology and in integration of the technology into applications environments. Applications that are described include (1) speech recognition and synthesis for mobile command and control; (2) speech processing for a portable multifunction soldier's computer; (3) speech- and language-based technology for naval combat team tactical training; (4) speech technology for command and control on a carrier flight deck; (5) control of auxiliary systems, and alert and warning generation, in fighter aircraft and helicopters; and (6) voice check-in, report entry, and communication for law enforcement agents or special forces. A phased approach for transfer of the technology into applications is advocated, where integration of applications systems is pursued in parallel with advanced research to meet future needs.

Methods of fabricating applique circuits

DOEpatents

Dimos, Duane B.; Garino, Terry J.

1999-09-14

Applique circuits suitable for advanced packaging applications are introduced. These structures are particularly suited for the simple integration of large amounts (many nanoFarads) of capacitance into conventional integrated circuit and multichip packaging technology. In operation, applique circuits are bonded to the integrated circuit or other appropriate structure at the point where the capacitance is required, thereby minimizing the effects of parasitic coupling. An immediate application is to problems of noise reduction and control in modern high-frequency circuitry.

Impact of Integrated Teaching Sessions for Comprehensive Learning and Rational Pharmacotherapeutics for Medical Undergraduates

PubMed Central

Ambwani, Sneha; Vegada, Bhavisha; Sidhu, Rimple; Charan, Jaykaran

2017-01-01

Background: It is postulated that integrated teaching method may enhance retention of the knowledge and clinical applicability of the basic sciences as compared to the didactic method. Aim: The present study was undertaken to compare the integrated teaching method with the didactic method for the learning ability and clinical applicability of the basic sciences. Materials and Methods: The 2nd year MBBS students were divided into two groups randomly. The study was conducted into two stages. In the first stage, conventional didactic lectures on hypertension (HT) were delivered to one group and multidisciplinary integrated teaching to another group. For the second stage, diabetes mellitus groups were swapped. Retention of the knowledge between the groups were assessed through a multiple choice questions (MCQ) test. Feedback of the students and faculty was obtained on a 5 point Likert scale. For the comparison, student's data were regrouped into four groups, i.e., integrated HT, didactic HT, integrated diabetes and didactic diabetes. Results: There was no significant difference of MCQ score between integrated HT, didactic HT, and integrated diabetes group. However, the score obtained in didactic diabetes was significantly more (P = 0.00) than other groups. Majority of the students favored integrated teaching for clinical application of basic science and learning of the skill for the future clinical practice. Faculties considered integrated method as a useful method and suggested frequent use of this method. Conclusion: There was no clear difference in knowledge acquisition; however, the students and faculties favored integrated teaching method in the feedback questionnaire. PMID:29344460

Integrating manufacturing softwares for intelligent planning execution: a CIIMPLEX perspective

NASA Astrophysics Data System (ADS)

Chu, Bei Tseng B.; Tolone, William J.; Wilhelm, Robert G.; Hegedus, M.; Fesko, J.; Finin, T.; Peng, Yun; Jones, Chris H.; Long, Junshen; Matthews, Mike; Mayfield, J.; Shimp, J.; Su, S.

1997-01-01

Recent developments have made it possible to interoperate complex business applications at much lower costs. Application interoperation, along with business process re- engineering can result in significant savings by eliminating work created by disconnected business processes due to isolated business applications. However, we believe much greater productivity benefits can be achieved by facilitating timely decision-making, utilizing information from multiple enterprise perspectives. The CIIMPLEX enterprise integration architecture is designed to enable such productivity gains by helping people to carry out integrated enterprise scenarios. An enterprise scenario is triggered typically by some external event. The goal of an enterprise scenario is to make the right decisions considering the full context of the problem. Enterprise scenarios are difficult for people to carry out because of the interdependencies among various actions. One can easily be overwhelmed by the large amount of information. We propose the use of software agents to help gathering relevant information and present them in the appropriate context of an enterprise scenario. The CIIMPLEX enterprise integration architecture is based on the FAIME methodology for application interoperation and plug-and-play. It also explores the use of software agents in application plug-and- play.

Macromodels of digital integrated circuits for program packages of circuit engineering design

NASA Astrophysics Data System (ADS)

Petrenko, A. I.; Sliusar, P. B.; Timchenko, A. P.

1984-04-01

Various aspects of the generation of macromodels of digital integrated circuits are examined, and their effective application in program packages of circuit engineering design is considered. Three levels of macromodels are identified, and the application of such models to the simulation of circuit outputs is discussed.

76 FR 17145 - Agency Information Collection Activities: Business Transformation-Automated Integrated Operating...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-28

... Collection Activities: Business Transformation--Automated Integrated Operating Environment (IOE), New... Transformation--Integrated Operating Environment (IOE); OMB Control No. 1615-NEW. SUMMARY: USCIS is developing an automated Integrated Operating Environment (IOE) to process benefit applications. The IOE will collect...

On the periodic Toda lattice hierarchy with an integral source

NASA Astrophysics Data System (ADS)

Babajanov, Bazar; Fečkan, Michal; Urazboev, Gayrat

2017-11-01

This work is devoted to the application of inverse spectral problem for integration of the periodic Toda lattice hierarchy with an integral type source. The effective method is presented of constructing the periodic Toda lattice hierarchy with an integral source.

Teleradiology applications with DICOM-e-mail.

PubMed

Weisser, G; Engelmann, U; Ruggiero, S; Runa, A; Schröter, A; Baur, S; Walz, M

2007-05-01

For the connection of several partners to a Dicom-e-mail based teleradiology network concepts were developed to allow the integration of different teleradiology applications. The organisational and technical needs for such an integration were analysed. More than 60 institutions including 23 hospitals in the Rhein-Neckar-Region, Germany were connected. The needed functionality was grouped in six teleradiology applications (emergency consultation, tele-guided examinations, expert consultations, cooperative work, scientific cooperations and homework with on call services) and their technical and organisational needs according to availability, speed of transfer, workflow definitions and data security needs was analysed. For the local integration of teleradiology services the setup and workflow is presented for a standalone teleradiology workstation and a server based teleradiology gateway. The line type needed for different groups of applications and users is defined. The security concept and fallback strategies are laid out, potential security problems and sources of errors are discussed. The specialties for the emergency teleradiology application are presented. The DICOM-e-mail protocol is a flexible and powerful protocol that can be used for a variety of teleradiology applications. It can meet the conditions for emergency applications but is limited if synchronous applications like teleconferences are needed.

Numerical methods for the simulation of complex multi-body flows with applications for the integrated Space Shuttle vehicle

NASA Technical Reports Server (NTRS)

Chan, William M.

1992-01-01

The following papers are presented: (1) numerical methods for the simulation of complex multi-body flows with applications for the Integrated Space Shuttle vehicle; (2) a generalized scheme for 3-D hyperbolic grid generation; (3) collar grids for intersecting geometric components within the Chimera overlapped grid scheme; and (4) application of the Chimera overlapped grid scheme to simulation of Space Shuttle ascent flows.

VHDL Modeling and Simulation of a Digital Image Synthesizer for Countering ISAR

DTIC Science & Technology

2003-06-01

This thesis discusses VHDL modeling and simulation of a full custom Application Specific Integrated Circuit (ASIC) for a Digital Image Synthesizer...necessary for a given application . With such a digital method, it is possible for a small ship to appear as large as an aircraft carrier or any high...INTRODUCTION TO DIGITAL IMAGE SYNTHESIZER (DIS) A. BACKGROUND The Digital Image Synthesizer (DIS) is an Application Specific Integrated Circuit

EXODUS: Integrating intelligent systems for launch operations support

NASA Technical Reports Server (NTRS)

Adler, Richard M.; Cottman, Bruce H.

1991-01-01

Kennedy Space Center (KSC) is developing knowledge-based systems to automate critical operations functions for the space shuttle fleet. Intelligent systems will monitor vehicle and ground support subsystems for anomalies, assist in isolating and managing faults, and plan and schedule shuttle operations activities. These applications are being developed independently of one another, using different representation schemes, reasoning and control models, and hardware platforms. KSC has recently initiated the EXODUS project to integrate these stand alone applications into a unified, coordinated intelligent operations support system. EXODUS will be constructed using SOCIAL, a tool for developing distributed intelligent systems. EXODUS, SOCIAL, and initial prototyping efforts using SOCIAL to integrate and coordinate selected EXODUS applications are described.

MEMS inertial sensors with integral rotation means.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kohler, Stewart M.

The state-of-the-art of inertial micro-sensors (gyroscopes and accelerometers) has advanced to the point where they are displacing the more traditional sensors in many size, power, and/or cost-sensitive applications. A factor limiting the range of application of inertial micro-sensors has been their relatively poor bias stability. The incorporation of an integral sensitive axis rotation capability would enable bias mitigation through proven techniques such as indexing, and foster the use of inertial micro-sensors in more accuracy-sensitive applications. Fabricating the integral rotation mechanism in MEMS technology would minimize the penalties associated with incorporation of this capability, and preserve the inherent advantages of inertialmore » micro-sensors.« less

HOLISTIC APPROACH FOR ASSESSING THE PRESENCE ...

EPA Pesticide Factsheets

As an integral part of our continuing research in environmental quality assessment approaches, we have developed a variety of passive integrative sampling devices widely applicable for use in defining the presence and potential impacts of a broad array of contaminants. The semipermeable membrane device (SPMD) has gained widespread use for sampling hydrophobic chemicals from water and air, the polar organic chemical integrative sampler (POCIS) is applicable for sequestering waterborne hydrophilic organic chemicals, the stabilized liquid membrane device (SLMD) is used to integratively sample waterborne ionic metals, and the passive integrative mercury sampler (PIMS) is applicable for sampling vapor phase or dissolved neutral mercury species. This suite of integrative samplers forms the basis for a new passive sampling approach for assessing the presence and potential toxicological significance of a broad spectrum of environmental contaminants. In a proof-of-concept study, three of our four passive integrative samplers were used to assess the presence o,f a wide variety of contaminants in , the waters of a constructed wetland, and to determine the effectiveness of the constructed wetland in removing contaminants. The wetland is used for fmal polishing of secondary- treatment municipal wastewater and the effluent is used as a source of water for a state wildlife area. Numerous contaminants, including organochlorine pesticides (OCs), polycyclic aromatic hydrocarbons

Elements for successful sensor-based process control {Integrated Metrology}

NASA Astrophysics Data System (ADS)

Butler, Stephanie Watts

1998-11-01

Current productivity needs have stimulated development of alternative metrology, control, and equipment maintenance methods. Specifically, sensor applications provide the opportunity to increase productivity, tighten control, reduce scrap, and improve maintenance schedules and procedures. Past experience indicates a complete integrated solution must be provided for sensor-based control to be used successfully in production. In this paper, Integrated Metrology is proposed as the term for an integrated solution that will result in a successful application of sensors for process control. This paper defines and explores the perceived four elements of successful sensor applications: business needs, integration, components, and form. Based upon analysis of existing successful commercially available controllers, the necessary business factors have been determined to be strong, measurable industry-wide business needs whose solution is profitable and feasible. This paper examines why the key aspect of integration is the decision making process. A detailed discussion is provided of the components of most importance to sensor based control: decision-making methods, the 3R's of sensors, and connectivity. A metric for one of the R's (resolution) is proposed to allow focus on this important aspect of measurement. A form for these integrated components which synergistically partitions various aspects of control at the equipment and MES levels to efficiently achieve desired benefits is recommended.

The application of the least squares finite element method to Abel's integral equation. [with application to glow discharge problem

NASA Technical Reports Server (NTRS)

Balasubramanian, R.; Norrie, D. H.; De Vries, G.

1979-01-01

Abel's integral equation is the governing equation for certain problems in physics and engineering, such as radiation from distributed sources. The finite element method for the solution of this non-linear equation is presented for problems with cylindrical symmetry and the extension to more general integral equations is indicated. The technique was applied to an axisymmetric glow discharge problem and the results show excellent agreement with previously obtained solutions

G189A analytical simulation of the RITE Integrated Waste Management-Water System

NASA Technical Reports Server (NTRS)

Coggi, J. V.; Clonts, S. E.

1974-01-01

This paper discusses the computer simulation of the Integrated Waste Management-Water System Using Radioisotopes for Thermal Energy (RITE) and applications of the simulation. Variations in the system temperature and flows due to particular operating conditions and variations in equipment heating loads imposed on the system were investigated with the computer program. The results were assessed from the standpoint of the computed dynamic characteristics of the system and the potential applications of the simulation to system development and vehicle integration.

J-Resistance Curves of Aluminum Specimens Using Moire Interferometry

DTIC Science & Technology

1989-04-01

elastic-plastic fracture mechanics ( EPFM ) methodologies are based on the J-integral or the crack opening displacement (COD) approach. The J-resistance curve...in the HRR field [13,141. In this paper, we present further application of the approximate J-evaluation procedure in large 2024-0 and 5052-H32 aluminum...Davis, J. A. Joyce, and R. A. Hays, " Application of the J-Integral and the Modified J-Integral to Cases of Large Crack Extension and High Toughness

Consuming Web Services: A Yahoo! Newsfeed Reader

ERIC Educational Resources Information Center

Dadashzadeh, Mohammad

2010-01-01

Service Oriented Architecture (SOA) shows demonstrable signs of simplifying software integration. It provides the necessary framework for building applications that can be integrated and can reduce the cost of integration significantly. Organizations are beginning to architect new integration solutions following the SOA approach. As such,…

Organizing integrated care in a university hospital: application of a conceptual framework.

PubMed

Axelsson, Runo; Axelsson, Susanna Bihari; Gustafsson, Jeppe; Seemann, Janne

2014-04-01

As a result of New Public Management, a number of industrial models of quality management have been implemented in health care, mainly in hospitals. At the same time, the concept of integrated care has been developed within other parts of the health sector. The aim of the article is to discuss the relevance of integrated care for hospitals. The discussion is based on application of a conceptual framework outlining a number of organizational models of integrated care. These models are illustrated in a case study of a Danish university hospital implementing a new organization for improving the patient flows of the hospital. The study of the reorganization is based mainly on qualitative data from individual and focus group interviews. The new organization of the university hospital can be regarded as a matrix structure combining a vertical integration of clinical departments with a horizontal integration of patient flows. This structure has elements of both interprofessional and interorganizational integration. A strong focus on teamwork, meetings and information exchange is combined with elements of case management and co-location. It seems that integrated care can be a relevant concept for a hospital. Although the organizational models may challenge established professional boundaries and financial control systems, this concept can be a more promising way to improve the quality of care than the industrial models that have been imported into health care. This application of the concept may also contribute to widen the field of integrated care.

Detection of orbital angular momentum using a photonic integrated circuit.

PubMed

Rui, Guanghao; Gu, Bing; Cui, Yiping; Zhan, Qiwen

2016-06-20

Orbital angular momentum (OAM) state of photons offer an attractive additional degree of freedom that has found a variety of applications. Measurement of OAM state, which is a critical task of these applications, demands photonic integrated devices for improved fidelity, miniaturization, and reconfiguration. Here we report the design of a silicon-integrated OAM receiver that is capable of detecting distinct and variable OAM states. Furthermore, the reconfiguration capability of the detector is achieved by applying voltage to the GeSe film to form gratings with alternate states. The resonant wavelength for arbitrary OAM state is demonstrated to be tunable in a quasi-linear manner through adjusting the duty cycle of the gratings. This work provides a viable approach for the realization of a compact integrated OAM detection device with enhanced functionality that may find important applications in optical communications and information processing with OAM states.

Summaries of the thematic conferences on remote sensing for exploration geology

NASA Technical Reports Server (NTRS)

1989-01-01

The Thematic Conference series was initiated to address the need for concentrated discussion of particular remote sensing applications. The program is primarily concerned with the application of remote sensing to mineral and hydrocarbon exploration, with special emphasis on data integration, methodologies, and practical solutions for geologists. Some fifty invited papers are scheduled for eleven plenary sessions, formulated to address such important topics as basement tectonics and their surface expressions, spectral geology, applications for hydrocarbon exploration, and radar applications and future systems. Other invited presentations will discuss geobotanical remote sensing, mineral exploration, engineering and environmental applications, advanced image processing, and integration and mapping.

Using LOTOS for Formalizing Wireless Sensor Network Applications

PubMed Central

Rosa, Nelson Souto; Cunha, Paulo Roberto Freire

2007-01-01

The number of wireless sensor network (WSN) applications is rapidly increasing and becoming an integral part of sensor nodes. These applications have been widely developed on TinyOS operating system using the nesC programming language. However, due to the tight integration to physical world, limited node power and resources (CPU and memory) and complexity of combining components into an application, to build such applications is not a trivial task. In this context, we present an approach for treating with this complexity adopting a formal description technique, namely LOTOS, for formalising the WSN applications ‘behaviour. The formalisation has three main benefits: better understanding on how the application actually works, checking of desired properties of the application's behaviour, and simulation facilities. In order to illustrate the proposed approach, we apply it to two nesC traditional applications, namely BLink and Sense.

Multimedia Instructional Tools and Student Learning in an Integrated Business Applications Course

ERIC Educational Resources Information Center

Wells, Sandra H.

2018-01-01

The purpose of this quantitative descriptive comparative study was to investigate and explore the usage of multimedia instructional tools (MMITs) in an integrated business applications course to determine if there was a statistically significant difference in the gain scores between the pretest and posttest scores of high school students who used…

Integrated remote sensing and visualization (IRSV) system for transportation infrastructure operations and management, phase one, volume 3 : use of scanning LiDAR in structural evaluation of bridges.

DOT National Transportation Integrated Search

2009-12-01

This volume introduces several applications of remote bridge inspection technologies studied in : this Integrated Remote Sensing and Visualization (IRSV) study using ground-based LiDAR : systems. In particular, the application of terrestrial LiDAR fo...

Understanding Introductory Students' Application of Integrals in Physics from Multiple Perspectives

ERIC Educational Resources Information Center

Hu, Dehui

2013-01-01

Calculus is used across many physics topics from introductory to upper-division level college courses. The concepts of differentiation and integration are important tools for solving real world problems. Using calculus or any mathematical tool in physics is much more complex than the straightforward application of the equations and algorithms that…

Detector arrays for low-background space infrared astronomy

NASA Technical Reports Server (NTRS)

Mccreight, C. R.; Mckelvey, M. E.; Goebel, J. H.; Anderson, G. M.; Lee, J. H.

1986-01-01

The status of development and characterization tests of integrated infrared detector array technology for astronomy applications is described. The devices under development include intrinsic, extrinsic silicon, and extrinsic germanium detectors, with hybrid silicon multiplexers. Laboratory test results and successful astronomy imagery have established the usefulness of integrated arrays in low-background astronomy applications.

Detector arrays for low-background space infrared astronomy

NASA Technical Reports Server (NTRS)

Mccreight, C. R.; Mckelvey, M. E.; Goebel, J. H.; Anderson, G. M.; Lee, J. H.

1986-01-01

The status of development and characterization tests of integrated infrared detector array technology for astronomy applications is described. The devices under development include intrinsic, extrinsic silicon, and extrinsic germanium detectors, with hybrid silicon multiplexers. Laboratary test results and successful astronomy imagery have established the usefulness of integrated arrays in low-background astronomy applications.

Integrated micro-electro-mechanical sensor development for inertial applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, J.J.; Kinney, R.D.; Sarsfield, J.

Electronic sensing circuitry and micro electro mechanical sense elements can be integrated to produce inertial instruments for applications unheard of a few years ago. This paper will describe the Sandia M3EMS fabrication process, inertial instruments that have been fabricated, and the results of initial characterization tests of micro-machined accelerometers.

Integrating Supplementary Application-Based Tutorials in the Multivariable Calculus Course

ERIC Educational Resources Information Center

Verner, I. M.; Aroshas, S.; Berman, A.

2008-01-01

This article presents a study in which applications were integrated in the Multivariable Calculus course at the Technion in the framework of supplementary tutorials. The purpose of the study was to test the opportunity of extending the conventional curriculum by optional applied problem-solving activities and get initial evidence on the possible…

Pattern of Classroom Activities during Students' Use of Computers: Relations between Instructional Strategies and Computer Applications

ERIC Educational Resources Information Center

Inan, Fethi A.; Lowther, Deborah L.; Ross, Steven M.; Strahl, Dan

2010-01-01

The purpose of this study was to identify instructional strategies used by teachers to support technology integration. In addition, relations between types of computer applications and teachers' classroom practices were examined. Data were direct observation results from 143 integration lessons implemented in schools receiving federal technology…

Integrating Existing Applications in Hypermedia Learning Material (General Issues & Experiences with OLE Technology).

ERIC Educational Resources Information Center

Borst Pauwels, H. W. J.; And Others

The integration of existing applications in hypermedia environments is a promising approach towards more flexible and user-friendly hypermedia learning materials. A hypermedia courseware editor, called HyDE (Hypermedia Document Editor) was developed using Microsoft Windows TM OLE technology. OLE (object Linking and Embedding) stands for an…

Adopting a Design-Thinking Multidisciplinary Learning Approach: Integrating Mobile Applications into a Marketing Research Course

ERIC Educational Resources Information Center

Zarzosa, Jennifer

2018-01-01

This article seeks to address the gap between marketing education and marketing practice by integrating a design-thinking (DT) methodology to the marketing research (MR) framework to achieve learning objectives that will enhance cross-functional, collaborative, conceptual, and technical skills. The mobile application marketing research project…

Digital Story-Based Problem Solving Applications: Preservice Primary Teachers' Experiences and Future Integration Plans

ERIC Educational Resources Information Center

Kilic, Çigdem; Sancar-Tokmak, Hatice

2017-01-01

This case study investigates how preservice primary school teachers describe their experiences with digital story-based problem solving applications and their plans for the future integration of this technology into their teaching. Totally 113 preservice primary school teachers participated in the study. Data collection tools included a…

The Environment for Application Software Integration and Execution (EASIE), version 1.0. Volume 2: Program integration guide

NASA Technical Reports Server (NTRS)

Jones, Kennie H.; Randall, Donald P.; Stallcup, Scott S.; Rowell, Lawrence F.

1988-01-01

The Environment for Application Software Integration and Execution, EASIE, provides a methodology and a set of software utility programs to ease the task of coordinating engineering design and analysis codes. EASIE was designed to meet the needs of conceptual design engineers that face the task of integrating many stand-alone engineering analysis programs. Using EASIE, programs are integrated through a relational data base management system. In volume 2, the use of a SYSTEM LIBRARY PROCESSOR is used to construct a DATA DICTIONARY describing all relations defined in the data base, and a TEMPLATE LIBRARY. A TEMPLATE is a description of all subsets of relations (including conditional selection criteria and sorting specifications) to be accessed as input or output for a given application. Together, these form the SYSTEM LIBRARY which is used to automatically produce the data base schema, FORTRAN subroutines to retrieve/store data from/to the data base, and instructions to a generic REVIEWER program providing review/modification of data for a given template. Automation of these functions eliminates much of the tedious, error prone work required by the usual approach to data base integration.

Application Agreement and Integration Services

NASA Technical Reports Server (NTRS)

Driscoll, Kevin R.; Hall, Brendan; Schweiker, Kevin

2013-01-01

Application agreement and integration services are required by distributed, fault-tolerant, safety critical systems to assure required performance. An analysis of distributed and hierarchical agreement strategies are developed against the backdrop of observed agreement failures in fielded systems. The documented work was performed under NASA Task Order NNL10AB32T, Validation And Verification of Safety-Critical Integrated Distributed Systems Area 2. This document is intended to satisfy the requirements for deliverable 5.2.11 under Task 4.2.2.3. This report discusses the challenges of maintaining application agreement and integration services. A literature search is presented that documents previous work in the area of replica determinism. Sources of non-deterministic behavior are identified and examples are presented where system level agreement failed to be achieved. We then explore how TTEthernet services can be extended to supply some interesting application agreement frameworks. This document assumes that the reader is familiar with the TTEthernet protocol. The reader is advised to read the TTEthernet protocol standard [1] before reading this document. This document does not re-iterate the content of the standard.

A Semantic Sensor Web for Environmental Decision Support Applications

PubMed Central

Gray, Alasdair J. G.; Sadler, Jason; Kit, Oles; Kyzirakos, Kostis; Karpathiotakis, Manos; Calbimonte, Jean-Paul; Page, Kevin; García-Castro, Raúl; Frazer, Alex; Galpin, Ixent; Fernandes, Alvaro A. A.; Paton, Norman W.; Corcho, Oscar; Koubarakis, Manolis; De Roure, David; Martinez, Kirk; Gómez-Pérez, Asunción

2011-01-01

Sensing devices are increasingly being deployed to monitor the physical world around us. One class of application for which sensor data is pertinent is environmental decision support systems, e.g., flood emergency response. For these applications, the sensor readings need to be put in context by integrating them with other sources of data about the surrounding environment. Traditional systems for predicting and detecting floods rely on methods that need significant human resources. In this paper we describe a semantic sensor web architecture for integrating multiple heterogeneous datasets, including live and historic sensor data, databases, and map layers. The architecture provides mechanisms for discovering datasets, defining integrated views over them, continuously receiving data in real-time, and visualising on screen and interacting with the data. Our approach makes extensive use of web service standards for querying and accessing data, and semantic technologies to discover and integrate datasets. We demonstrate the use of our semantic sensor web architecture in the context of a flood response planning web application that uses data from sensor networks monitoring the sea-state around the coast of England. PMID:22164110

Integrating distributed multimedia systems and interactive television networks

NASA Astrophysics Data System (ADS)

Shvartsman, Alex A.

1996-01-01

Recent advances in networks, storage and video delivery systems are about to make commercial deployment of interactive multimedia services over digital television networks a reality. The emerging components individually have the potential to satisfy the technical requirements in the near future. However, no single vendor is offering a complete end-to-end commercially-deployable and scalable interactive multimedia applications systems over digital/analog television systems. Integrating a large set of maturing sub-assemblies and interactive multimedia applications is a major task in deploying such systems. Here we deal with integration issues, requirements and trade-offs in building delivery platforms and applications for interactive television services. Such integration efforts must overcome lack of standards, and deal with unpredictable development cycles and quality problems of leading- edge technology. There are also the conflicting goals of optimizing systems for video delivery while enabling highly interactive distributed applications. It is becoming possible to deliver continuous video streams from specific sources, but it is difficult and expensive to provide the ability to rapidly switch among multiple sources of video and data. Finally, there is the ever- present challenge of integrating and deploying expensive systems whose scalability and extensibility is limited, while ensuring some resiliency in the face of inevitable changes. This proceedings version of the paper is an extended abstract.

Sensing systems using chip-based spectrometers

NASA Astrophysics Data System (ADS)

Nitkowski, Arthur; Preston, Kyle J.; Sherwood-Droz, Nicolás.; Behr, Bradford B.; Bismilla, Yusuf; Cenko, Andrew T.; DesRoches, Brandon; Meade, Jeffrey T.; Munro, Elizabeth A.; Slaa, Jared; Schmidt, Bradley S.; Hajian, Arsen R.

2014-06-01

Tornado Spectral Systems has developed a new chip-based spectrometer called OCTANE, the Optical Coherence Tomography Advanced Nanophotonic Engine, built using a planar lightwave circuit with integrated waveguides fabricated on a silicon wafer. While designed for spectral domain optical coherence tomography (SD-OCT) systems, the same miniaturized technology can be applied to many other spectroscopic applications. The field of integrated optics enables the design of complex optical systems which are monolithically integrated on silicon chips. The form factors of these systems can be significantly smaller, more robust and less expensive than their equivalent free-space counterparts. Fabrication techniques and material systems developed for microelectronics have previously been adapted for integrated optics in the telecom industry, where millions of chip-based components are used to power the optical backbone of the internet. We have further adapted the photonic technology platform for spectroscopy applications, allowing unheard-of economies of scale for these types of optical devices. Instead of changing lenses and aligning systems, these devices are accurately designed programmatically and are easily customized for specific applications. Spectrometers using integrated optics have large advantages in systems where size, robustness and cost matter: field-deployable devices, UAVs, UUVs, satellites, handheld scanning and more. We will discuss the performance characteristics of our chip-based spectrometers and the type of spectral sensing applications enabled by this technology.

[The Application of Information and Communication Technology (ICT) in Nursing Education].

PubMed

Chiou, Shwu-Fen; Su, Hsiu-Chuan; Huang, Ean-Wen

2017-12-01

With the rapid development of information and communication technologies (ICT) in the 21st century, all walks of life have experienced disruptive changes, including the healthcare profession. Although nurses represent the largest number of professionals in medical institutions, it is doubtful whether nurses possess sufficient capabilities to face challenges in this era of rapid medical informatization. Currently, the courses necessary to cultivate information literacy in nursing students are insufficient in Taiwan, and traditional instruction methods are largely adopted as nursing teaching strategies. Additionally, most teachers hold a passive attitude towards the application of ICT in teaching. On the contrary, ICT have been integrated into nursing education in many countries around the world for nearly 20 years, achieving good levels of teaching efficacy. Reflecting the Taiwan government's promotion of digital learning projects, academic circles in various fields have also started to gradually integrate ICT into teaching. Nursing educators in Taiwan have much to reference and to learn from these disparate integration experiences. Therefore, this article introduces the concepts of integration of ICT into teaching, the current status of the application of ICT in international nursing education, and the issues faced during this application as a reference for nursing education in Taiwan in order to promote the integration of ICT into nursing education.

Advances in three-dimensional integral imaging: sensing, display, and applications [Invited].

PubMed

Xiao, Xiao; Javidi, Bahram; Martinez-Corral, Manuel; Stern, Adrian

2013-02-01

Three-dimensional (3D) sensing and imaging technologies have been extensively researched for many applications in the fields of entertainment, medicine, robotics, manufacturing, industrial inspection, security, surveillance, and defense due to their diverse and significant benefits. Integral imaging is a passive multiperspective imaging technique, which records multiple two-dimensional images of a scene from different perspectives. Unlike holography, it can capture a scene such as outdoor events with incoherent or ambient light. Integral imaging can display a true 3D color image with full parallax and continuous viewing angles by incoherent light; thus it does not suffer from speckle degradation. Because of its unique properties, integral imaging has been revived over the past decade or so as a promising approach for massive 3D commercialization. A series of key articles on this topic have appeared in the OSA journals, including Applied Optics. Thus, it is fitting that this Commemorative Review presents an overview of literature on physical principles and applications of integral imaging. Several data capture configurations, reconstruction, and display methods are overviewed. In addition, applications including 3D underwater imaging, 3D imaging in photon-starved environments, 3D tracking of occluded objects, 3D optical microscopy, and 3D polarimetric imaging are reviewed.

Early Experiences with Mobile Electronic Health Records Application in a Tertiary Hospital in Korea

PubMed Central

Park, Minah; Hong, Eunseok; Kim, Sunhyu; Ahn, Ryeok; Hong, Jungseok; Song, Seungyeol; Kim, Tak; Kim, Jeongkeun; Yeo, Seongwoon

2015-01-01

Objectives Recent advances in mobile technology have opened up possibilities to provide strongly integrated mobile-based services in healthcare and telemedicine. Although the number of mobile Electronic Health Record (EHR) applications is large and growing, there is a paucity of evidence demonstrating the usage patterns of these mobile applications by healthcare providers. This study aimed to illustrate the deployment process for an integrated mobile EHR application and to analyze usage patterns after provision of the mobile EHR service. Methods We developed an integrated mobile application that aimed to enhance the mobility of healthcare providers by improving access to patient- and hospital-related information during their daily medical activities. The study included mobile EHR users who accessed patient healthcare records between May 2013 and May 2014. We performed a data analysis using a web server log file analyzer from the integrated EHR system. Cluster analysis was applied to longitudinal user data based on their application usage pattern. Results The mobile EHR service named M-UMIS has been in service since May 2013. Every healthcare provider in the hospital could access the mobile EHR service and view the medical charts of their patients. The frequency of using services and network packet transmission on the M-UMIS increased gradually during the study period. The most frequently accessed service in the menu was the patient list. Conclusions A better understanding regarding the adoption of mobile EHR applications by healthcare providers in patient-centered care provides useful information to guide the design and implementation of future applications. PMID:26618036

Future applications of artificial intelligence to Mission Control Centers

NASA Technical Reports Server (NTRS)

Friedland, Peter

1991-01-01

Future applications of artificial intelligence to Mission Control Centers are presented in the form of the viewgraphs. The following subject areas are covered: basic objectives of the NASA-wide AI program; inhouse research program; constraint-based scheduling; learning and performance improvement for scheduling; GEMPLAN multi-agent planner; planning, scheduling, and control; Bayesian learning; efficient learning algorithms; ICARUS (an integrated architecture for learning); design knowledge acquisition and retention; computer-integrated documentation; and some speculation on future applications.

Boolean integral calculus for digital systems

NASA Technical Reports Server (NTRS)

Tucker, J. H.; Tapia, M. A.; Bennett, A. W.

1985-01-01

The concept of Boolean integration is introduced and developed. When the changes in a desired function are specified in terms of changes in its arguments, then ways of 'integrating' (i.e., realizing) the function, if it exists, are presented. Boolean integral calculus has applications in design of logic circuits.

Vertical integration of basic science in final year of medical education.

PubMed

Rajan, Sudha Jasmine; Jacob, Tripti Meriel; Sathyendra, Sowmya

2016-01-01

Development of health professionals with ability to integrate, synthesize, and apply knowledge gained through medical college is greatly hampered by the system of delivery that is compartmentalized and piecemeal. There is a need to integrate basic sciences with clinical teaching to enable application in clinical care. To study the benefit and acceptance of vertical integration of basic science in final year MBBS undergraduate curriculum. After Institutional Ethics Clearance, neuroanatomy refresher classes with clinical application to neurological diseases were held as part of the final year posting in two medical units. Feedback was collected. Pre- and post-tests which tested application and synthesis were conducted. Summative assessment was compared with the control group of students who had standard teaching in other two medical units. In-depth interview was conducted on 2 willing participants and 2 teachers who did neurology bedside teaching. Majority (>80%) found the classes useful and interesting. There was statistically significant improvement in the post-test scores. There was a statistically significant difference between the intervention and control groups' scores during summative assessment (76.2 vs. 61.8 P < 0.01). Students felt that it reinforced, motivated self-directed learning, enabled correlations, improved understanding, put things in perspective, gave confidence, aided application, and enabled them to follow discussions during clinical teaching. Vertical integration of basic science in final year was beneficial and resulted in knowledge gain and improved summative scores. The classes were found to be useful, interesting and thought to help in clinical care and application by majority of students.

Methodology and application of combined watershed and ground-water models in Kansas

USGS Publications Warehouse

Sophocleous, M.; Perkins, S.P.

2000-01-01

Increased irrigation in Kansas and other regions during the last several decades has caused serious water depletion, making the development of comprehensive strategies and tools to resolve such problems increasingly important. This paper makes the case for an intermediate complexity, quasi-distributed, comprehensive, large-watershed model, which falls between the fully distributed, physically based hydrological modeling system of the type of the SHE model and the lumped, conceptual rainfall-runoff modeling system of the type of the Stanford watershed model. This is achieved by integrating the quasi-distributed watershed model SWAT with the fully-distributed ground-water model MODFLOW. The advantage of this approach is the appreciably smaller input data requirements and the use of readily available data (compared to the fully distributed, physically based models), the statistical handling of watershed heterogeneities by employing the hydrologic-response-unit concept, and the significantly increased flexibility in handling stream-aquifer interactions, distributed well withdrawals, and multiple land uses. The mechanics of integrating the component watershed and ground-water models are outlined, and three real-world management applications of the integrated model from Kansas are briefly presented. Three different aspects of the integrated model are emphasized: (1) management applications of a Decision Support System for the integrated model (Rattlesnake Creek subbasin); (2) alternative conceptual models of spatial heterogeneity related to the presence or absence of an underlying aquifer with shallow or deep water table (Lower Republican River basin); and (3) the general nature of the integrated model linkage by employing a watershed simulator other than SWAT (Wet Walnut Creek basin). These applications demonstrate the practicality and versatility of this relatively simple and conceptually clear approach, making public acceptance of the integrated watershed modeling system much easier. This approach also enhances model calibration and thus the reliability of model results. (C) 2000 Elsevier Science B.V.Increased irrigation in Kansas and other regions during the last several decades has caused serious water depletion, making the development of comprehensive strategies and tools to resolve such problems increasingly important. This paper makes the case for an intermediate complexity, quasi-distributed, comprehensive, large-watershed model, which falls between the fully distributed, physically based hydrological modeling system of the type of the SHE model and the lumped, conceptual rainfall-runoff modeling system of the type of the Stanford watershed model. This is achieved by integrating the quasi-distributed watershed model SWAT with the fully-distributed ground-water model MODFLOW. The advantage of this approach is the appreciably smaller input data requirements and the use of readily available data (compared to the fully distributed, physically based models), the statistical handling of watershed heterogeneities by employing the hydrologic-response-unit concept, and the significantly increased flexibility in handling stream-aquifer interactions, distributed well withdrawals, and multiple land uses. The mechanics of integrating the component watershed and ground-water models are outlined, and three real-world management applications of the integrated model from Kansas are briefly presented. Three different aspects of the integrated model are emphasized: (1) management applications of a Decision Support System for the integrated model (Rattlesnake Creek subbasin); (2) alternative conceptual models of spatial heterogeneity related to the presence or absence of an underlying aquifer with shallow or deep water table (Lower Republican River basin); and (3) the general nature of the integrated model linkage by employing a watershed simulator other than SWAT (Wet Walnut Creek basin). These applications demonstrate the practicality and ve

Concept-Based Arts Integration: Lessons Learned from an Application in Music and Biology

ERIC Educational Resources Information Center

Wolkowicz, Terry

2017-01-01

Arts integration has been a mixed blessing, with both the potential for developing deeper understandings amid concerns that it diminishes the integrity and authenticity of learning in the arts. This article describes concept-based arts integration as a model of arts integration where curriculum is designed around shared concepts that connect…

Smart Sensor Systems for Aerospace Applications: From Sensor Development to Application Testing

NASA Technical Reports Server (NTRS)

Hunter, G. W.; Xu, J. C.; Dungan, L. K.; Ward, B. J.; Rowe, S.; Williams, J.; Makel, D. B.; Liu, C. C.; Chang, C. W.

2008-01-01

The application of Smart Sensor Systems for aerospace applications is a multidisciplinary process consisting of sensor element development, element integration into Smart Sensor hardware, and testing of the resulting sensor systems in application environments. This paper provides a cross-section of these activities for multiple aerospace applications illustrating the technology challenges involved. The development and application testing topics discussed are: 1) The broadening of sensitivity and operational range of silicon carbide (SiC) Schottky gas sensor elements; 2) Integration of fire detection sensor technology into a "Lick and Stick" Smart Sensor hardware platform for Crew Exploration Vehicle applications; 3) Extended testing for zirconia based oxygen sensors in the basic "Lick and Stick" platform for environmental monitoring applications. It is concluded that that both core sensor platform technology and a basic hardware platform can enhance the viability of implementing smart sensor systems in aerospace applications.

[Study on eco-climatic applicability of Angelica sinensis].

PubMed

Deng, Zhen-Yong; Yin, Xian-Zhi; Yin, Dong; Yang, Qi-Guo; Zhu, Guo-Qing; Liu, Ming-Chun

2005-06-01

In the interest of establish planting base of Angelica sinensis on a large scale, enhance economic benefit, and improve decision-making reasons, the eco-climatic applicability of A. sinensis was studied. Using integral regression, eco-climatic applicability and the effect of meteorological conditions for the yield of A. sinensis' were analysed by field experimental data. Selected > or =0 degrees C accumulated temperature and annual precipitation as leading index, altitude as assistant index, yield and rate of finished products as reference index, the integrated eco-climatic division index and the planting division applicability of A. sinensis was confirmed. Accordancing to theory of climate similitude and leading index summarisation, combining with assistant index and reference index, the integrated division index of eco-climate was confirmed. The planting division of co-climate applicability was divided into 5 grades as best suitable, suitable hypo-suitable, just suitable and no suitable regions. At the same time,the way to enhanced utilizing efficiency of eco-climate resources was brought forward.

Integrated Toolset for WSN Application Planning, Development, Commissioning and Maintenance: The WSN-DPCM ARTEMIS-JU Project.

PubMed

Antonopoulos, Christos; Asimogloy, Katerina; Chiti, Sarah; D'Onofrio, Luca; Gianfranceschi, Simone; He, Danping; Iodice, Antonio; Koubias, Stavros; Koulamas, Christos; Lavagno, Luciano; Lazarescu, Mihai T; Mujica, Gabriel; Papadopoulos, George; Portilla, Jorge; Redondo, Luis; Riccio, Daniele; Riesgo, Teresa; Rodriguez, Daniel; Ruello, Giuseppe; Samoladas, Vasilis; Stoyanova, Tsenka; Touliatos, Gerasimos; Valvo, Angela; Vlahoy, Georgia

2016-06-02

In this article we present the main results obtained in the ARTEMIS-JU WSN-DPCM project between October 2011 and September 2015. The first objective of the project was the development of an integrated toolset for Wireless sensor networks (WSN) application planning, development, commissioning and maintenance, which aims to support application domain experts, with limited WSN expertise, to efficiently develop WSN applications from planning to lifetime maintenance. The toolset is made of three main tools: one for planning, one for application development and simulation (which can include hardware nodes), and one for network commissioning and lifetime maintenance. The tools are integrated in a single platform which promotes software reuse by automatically selecting suitable library components for application synthesis and the abstraction of the underlying architecture through the use of a middleware layer. The second objective of the project was to test the effectiveness of the toolset for the development of two case studies in different domains, one for detecting the occupancy state of parking lots and one for monitoring air concentration of harmful gasses near an industrial site.

Integrated Toolset for WSN Application Planning, Development, Commissioning and Maintenance: The WSN-DPCM ARTEMIS-JU Project

PubMed Central

Antonopoulos, Christos; Asimogloy, Katerina; Chiti, Sarah; D’Onofrio, Luca; Gianfranceschi, Simone; He, Danping; Iodice, Antonio; Koubias, Stavros; Koulamas, Christos; Lavagno, Luciano; Lazarescu, Mihai T.; Mujica, Gabriel; Papadopoulos, George; Portilla, Jorge; Redondo, Luis; Riccio, Daniele; Riesgo, Teresa; Rodriguez, Daniel; Ruello, Giuseppe; Samoladas, Vasilis; Stoyanova, Tsenka; Touliatos, Gerasimos; Valvo, Angela; Vlahoy, Georgia

2016-01-01

In this article we present the main results obtained in the ARTEMIS-JU WSN-DPCM project between October 2011 and September 2015. The first objective of the project was the development of an integrated toolset for Wireless sensor networks (WSN) application planning, development, commissioning and maintenance, which aims to support application domain experts, with limited WSN expertise, to efficiently develop WSN applications from planning to lifetime maintenance. The toolset is made of three main tools: one for planning, one for application development and simulation (which can include hardware nodes), and one for network commissioning and lifetime maintenance. The tools are integrated in a single platform which promotes software reuse by automatically selecting suitable library components for application synthesis and the abstraction of the underlying architecture through the use of a middleware layer. The second objective of the project was to test the effectiveness of the toolset for the development of two case studies in different domains, one for detecting the occupancy state of parking lots and one for monitoring air concentration of harmful gasses near an industrial site. PMID:27271622

Twelve Principles for Green Energy Storage in Grid Applications.

PubMed

Arbabzadeh, Maryam; Johnson, Jeremiah X; Keoleian, Gregory A; Rasmussen, Paul G; Thompson, Levi T

2016-01-19

The introduction of energy storage technologies to the grid could enable greater integration of renewables, improve system resilience and reliability, and offer cost effective alternatives to transmission and distribution upgrades. The integration of energy storage systems into the electrical grid can lead to different environmental outcomes based on the grid application, the existing generation mix, and the demand. Given this complexity, a framework is needed to systematically inform design and technology selection about the environmental impacts that emerge when considering energy storage options to improve sustainability performance of the grid. To achieve this, 12 fundamental principles specific to the design and grid application of energy storage systems are developed to inform policy makers, designers, and operators. The principles are grouped into three categories: (1) system integration for grid applications, (2) the maintenance and operation of energy storage, and (3) the design of energy storage systems. We illustrate the application of each principle through examples published in the academic literature, illustrative calculations, and a case study with an off-grid application of vanadium redox flow batteries (VRFBs). In addition, trade-offs that can emerge between principles are highlighted.

Integration Telegram Bot on E-Complaint Applications in College

NASA Astrophysics Data System (ADS)

Rosid, M. A.; Rachmadany, A.; Multazam, M. T.; Nandiyanto, A. B. D.; Abdullah, A. G.; Widiaty, I.

2018-01-01

Internet of Things (IoT) has influenced human life where IoT internet connectivity extending from human-to-humans to human-to-machine or machine-to-machine. With this research field, it will be created a technology and concepts that allow humans to communicate with machines for a specific purpose. This research aimed to integrate between application service of the telegram sender with application of e-complaint at a college. With this application, users do not need to visit the Url of the E-compliant application; but, they can be accessed simply by submitting a complaint via Telegram, and then the complaint will be forwarded to the E-complaint Application. From the test results, e-complaint integration with Telegram Bot has been run in accordance with the design. Telegram Bot is made able to provide convenience to the user in this academician to submit a complaint, besides the telegram bot provides the user interaction with the usual interface used by people everyday on their smartphones. Thus, with this system, the complained work unit can immediately make improvements since all the complaints process can be delivered rapidly.

Heterogeneous Silicon III-V Mode-Locked Lasers

NASA Astrophysics Data System (ADS)

Davenport, Michael Loehrlein

Mode-locked lasers are useful for a variety of applications, such as sensing, telecommunication, and surgical instruments. This work focuses on integrated-circuit mode-locked lasers: those that combine multiple optical and electronic functions and are manufactured together on a single chip. While this allows production at high volume and lower cost, the true potential of integration is to open applications for mode-locked laser diodes where solid state lasers cannot fit, either due to size and power consumption constraints, or where small optical or electrical paths are needed for high bandwidth. Unfortunately, most high power and highly stable mode-locked laser diode demonstrations in scientific literature are based on the Fabry-Perot resonator design, with cleaved mirrors, and are unsuitable for use in integrated circuits because of the difficulty of producing integrated Fabry-Perot cavities. We use silicon photonics and heterogeneous integration with III-V gain material to produce the most powerful and lowest noise fully integrated mode-locked laser diode in the 20 GHz frequency range. If low noise and high peak power are required, it is arguably the best performing fully integrated mode-locked laser ever demonstrated. We present the design methodology and experimental pathway to realize a fully integrated mode-locked laser diode. The construction of the device, beginning with the selection of an integration platform, and proceeding through the fabrication process to final optimization, is presented in detail. The dependence of mode-locked laser performance on a wide variety of design parameters is presented. Applications for integrated circuit mode-locked lasers are also discussed, as well as proposed methods for using integration to improve mode-locking performance to beyond the current state of the art.

On-the-fly Locata/inertial navigation system integration for precise maritime application

NASA Astrophysics Data System (ADS)

Jiang, Wei; Li, Yong; Rizos, Chris

2013-10-01

The application of Global Navigation Satellite System (GNSS) technology has meant that marine navigators have greater access to a more consistent and accurate positioning capability than ever before. However, GNSS may not be able to meet all emerging navigation performance requirements for maritime applications with respect to service robustness, accuracy, integrity and availability. In particular, applications in port areas (for example automated docking) and in constricted waterways, have very stringent performance requirements. Even when an integrated inertial navigation system (INS)/GNSS device is used there may still be performance gaps. GNSS signals are easily blocked or interfered with, and sometimes the satellite geometry may not be good enough for high accuracy and high reliability applications. Furthermore, the INS accuracy degrades rapidly during GNSS outages. This paper investigates the use of a portable ground-based positioning system, known as ‘Locata’, which was integrated with an INS, to provide accurate navigation in a marine environment without reliance on GNSS signals. An ‘on-the-fly’ Locata resolution algorithm that takes advantage of geometry change via an extended Kalman filter is proposed in this paper. Single-differenced Locata carrier phase measurements are utilized to achieve accurate and reliable solutions. A ‘loosely coupled’ decentralized Locata/INS integration architecture based on the Kalman filter is used for data processing. In order to evaluate the system performance, a field trial was conducted on Sydney Harbour. A Locata network consisting of eight Locata transmitters was set up near the Sydney Harbour Bridge. The experiment demonstrated that the Locata on-the-fly (OTF) algorithm is effective and can improve the system accuracy in comparison with the conventional ‘known point initialization’ (KPI) method. After the OTF and KPI comparison, the OTF Locata/INS integration is then assessed further and its performance improvement on both stand-alone OTF Locata and INS is shown. The Locata/INS integration can achieve centimetre-level accuracy for position solutions, and centimetre-per-second accuracy for velocity determination.

Military and government applications of human-machine communication by voice.

PubMed Central

Weinstein, C J

1995-01-01

This paper describes a range of opportunities for military and government applications of human-machine communication by voice, based on visits and contacts with numerous user organizations in the United States. The applications include some that appear to be feasible by careful integration of current state-of-the-art technology and others that will require a varying mix of advances in speech technology and in integration of the technology into applications environments. Applications that are described include (1) speech recognition and synthesis for mobile command and control; (2) speech processing for a portable multifunction soldier's computer; (3) speech- and language-based technology for naval combat team tactical training; (4) speech technology for command and control on a carrier flight deck; (5) control of auxiliary systems, and alert and warning generation, in fighter aircraft and helicopters; and (6) voice check-in, report entry, and communication for law enforcement agents or special forces. A phased approach for transfer of the technology into applications is advocated, where integration of applications systems is pursued in parallel with advanced research to meet future needs. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:7479718

Teaching Integration Applications Using Manipulatives

ERIC Educational Resources Information Center

Bhatia, Kavita; Premadasa, Kirthi; Martin, Paul

2014-01-01

Calculus students' difficulties in understanding integration have been extensively studied. Research shows that the difficulty lies with students understanding of the definition of the definite integral as a limit of a Riemann sum and with the idea of accumulation inherent in integration. We have created a set of manipulatives and activities…

49 CFR 1106.4 - The Safety Integration Plan process.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 8 2011-10-01 2011-10-01 false The Safety Integration Plan process. 1106.4... CONSIDERATION OF SAFETY INTEGRATION PLANS IN CASES INVOLVING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL § 1106.4 The Safety Integration Plan process. (a) Each applicant in a transaction subject...

49 CFR 1106.4 - The Safety Integration Plan process.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 8 2013-10-01 2013-10-01 false The Safety Integration Plan process. 1106.4... CONSIDERATION OF SAFETY INTEGRATION PLANS IN CASES INVOLVING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL § 1106.4 The Safety Integration Plan process. (a) Each applicant in a transaction subject...

49 CFR 1106.4 - The Safety Integration Plan process.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 8 2014-10-01 2014-10-01 false The Safety Integration Plan process. 1106.4... CONSIDERATION OF SAFETY INTEGRATION PLANS IN CASES INVOLVING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL § 1106.4 The Safety Integration Plan process. (a) Each applicant in a transaction subject...

49 CFR 1106.4 - The Safety Integration Plan process.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 8 2012-10-01 2012-10-01 false The Safety Integration Plan process. 1106.4... CONSIDERATION OF SAFETY INTEGRATION PLANS IN CASES INVOLVING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL § 1106.4 The Safety Integration Plan process. (a) Each applicant in a transaction subject...

49 CFR 1106.4 - The Safety Integration Plan process.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 8 2010-10-01 2010-10-01 false The Safety Integration Plan process. 1106.4... CONSIDERATION OF SAFETY INTEGRATION PLANS IN CASES INVOLVING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL § 1106.4 The Safety Integration Plan process. (a) Each applicant in a transaction subject...

Strategies to promote a climate of academic integrity and minimize student cheating and plagiarism.

PubMed

Scanlan, Craig L

2006-01-01

Student academic misconduct is a growing problem for colleges and universities, including those responsible for preparing health professionals. Although the implementation of honor codes has had a positive impact on this problem, further reduction in student cheating and plagiarism can be achieved only via a comprehensive strategy that promotes an institutional culture of academic integrity. Such a strategy must combine efforts both to deter and detect academic misconduct, along with fair but rigorous application of sanctions against such behaviors. Methods useful in preventing or deterring dishonest behaviors among students include early integrity training complemented with course-level reinforcement, faculty role-modeling, and the application of selected testing/assignment preventive strategies, including honor pledges and honesty declarations. Giving students more responsibility for oversight of academic integrity also may help address this problem and better promote the culture needed to uphold its principles. Successful enforcement requires that academic administration provide strong and visible support for upholding academic integrity standards, including the provision of a clear and fair process and the consistent application of appropriate sanctions against those whose conduct is found to violate these standards.

Non-invasive hyperthermia apparatus including coaxial applicator having a non-invasive radiometric receiving antenna incorporated therein and method of use thereof

DOEpatents

Ross, Michael P.

1996-01-01

A coaxial hyperthermia applicator for applying non-invasively electromagnetic energy to a body against which it is placed. The coaxial applicator antenna has formed integrally within it a non-invasive radiometric antenna for receiving thermoelectromagnetic emissions. The coaxial-configured applicator produces a bell-shaped radiation pattern symmetric about the axis of symmetry of the coaxial applicator. Integrating the radiometric antenna within the coaxial applicator produces a single device that performs dual functions. The first function is to transmit non-invasively energy for heating a subcutaneous tumor. The second function is to receive non-invasively thermal electromagnetic radiation from the tumor by which temperature is sensed and fed back to control the output of the coaxial applicator.

Non-invasive hyperthermia apparatus including coaxial applicator having a non-invasive radiometric receiving antenna incorporated therein and method of use thereof

DOEpatents

Ross, M.P.

1996-08-27

A coaxial hyperthermia applicator is disclosed for applying non-invasively electromagnetic energy to a body against which it is placed. The coaxial applicator antenna has formed integrally within it a non-invasive radiometric antenna for receiving thermoelectromagnetic emissions. The coaxial-configured applicator produces a bell-shaped radiation pattern symmetric about the axis of symmetry of the coaxial applicator. Integrating the radiometric antenna within the coaxial applicator produces a single device that performs dual functions. The first function is to transmit non-invasively energy for heating a subcutaneous tumor. The second function is to receive non-invasively thermal electromagnetic radiation from the tumor by which temperature is sensed and fed back to control the output of the coaxial applicator. 11 figs.

Applications for fiber optic sensing in the upstream oil and gas industry

NASA Astrophysics Data System (ADS)

Baldwin, Chris S.

2015-05-01

Fiber optic sensing has been used in an increasing number of applications in the upstream oil and gas industry over the past 20 years. In some cases, fiber optic sensing is providing measurements where traditional measurement technologies could not. This paper will provide a general overview of these applications and describe how the use of fiber optic sensing is enabling these applications. Technologies such as Bragg gratings, distributed temperature and acoustic sensing, interferometric sensing, and Brillouin scattering will be discussed. Applications for optic sensing include a range of possibilities from a single pressure measurement point in the wellbore to multizone pressure and flow monitoring. Some applications make use of fully distributed measurements including thermal profiling of the well. Outside of the wellbore, fiber optic sensors are used in applications for flowline and pipeline monitoring and for riser integrity monitoring. Applications to be described in this paper include in-flow profiling, well integrity, production monitoring, and steam chamber growth. These applications will cover well types such as injectors, producers, hydraulic fracturing, and thermal recovery. Many of these applications use the measurements provided by fiber optic sensing to improve enhanced oil recovery operations. The growing use of fiber optic sensors is providing improved measurement capabilities leading to the generation of actionable data for enhanced production optimization. This not only increases the recovered amount of production fluids but can also enhance wellbore integrity and safety.

Organic and inorganic fertilizer effect on soil CO2 flux, microbial biomass, and growth of Nigella sativa L.

NASA Astrophysics Data System (ADS)

Salehi, Aliyeh; Fallah, Seyfollah; Sourki, Ali Abasi

2017-01-01

Cattle manure has a high carbon/nitrogen ratio and may not decompose; therefore, full-dose application of urea fertilizer might improve biological properties by increasing manure decomposition. This study aimed to investigate the effect of combining cattle manure and urea fertilizer on soil CO2 flux, microbial biomass carbon, and dry matter accumulation during Nigella sativa L. (black cumin) growth under field conditions. The treatments were control, cattle manure, urea, different levels of split and full-dose integrated fertilizer. The results showed that integrated application of cattle manure and chemical fertilizer significantly increased microbial biomass carbon by 10%, soil organic carbon by 2.45%, total N by 3.27%, mineral N at the flowering stage by 7.57%, and CO2 flux by 9% over solitary urea application. Integrated application increased microbial biomass carbon by 10% over the solitary application and the full-dose application by 5% over the split application. The soil properties and growth parameters of N. sativa L. benefited more from the full-dose application than the split application of urea. Cattle manure combined with chemical fertilizer and the full-dose application of urea increased fertilizer efficiency and improved biological soil parameters and plant growth. This method decreased the cost of top dressing urea fertilizer and proved beneficial for the environment and medicinal plant health.

Biomedical Ontologies in Action: Role in Knowledge Management, Data Integration and Decision Support

PubMed Central

Bodenreider, O.

2008-01-01

Summary Objectives To provide typical examples of biomedical ontologies in action, emphasizing the role played by biomedical ontologies in knowledge management, data integration and decision support. Methods Biomedical ontologies selected for their practical impact are examined from a functional perspective. Examples of applications are taken from operational systems and the biomedical literature, with a bias towards recent journal articles. Results The ontologies under investigation in this survey include SNOMED CT, the Logical Observation Identifiers, Names, and Codes (LOINC), the Foundational Model of Anatomy, the Gene Ontology, RxNorm, the National Cancer Institute Thesaurus, the International Classification of Diseases, the Medical Subject Headings (MeSH) and the Unified Medical Language System (UMLS). The roles played by biomedical ontologies are classified into three major categories: knowledge management (indexing and retrieval of data and information, access to information, mapping among ontologies); data integration, exchange and semantic interoperability; and decision support and reasoning (data selection and aggregation, decision support, natural language processing applications, knowledge discovery). Conclusions Ontologies play an important role in biomedical research through a variety of applications. While ontologies are used primarily as a source of vocabulary for standardization and integration purposes, many applications also use them as a source of computable knowledge. Barriers to the use of ontologies in biomedical applications are discussed. PMID:18660879

Project Integration Architecture: Implementation of the CORBA-Served Application Infrastructure

NASA Technical Reports Server (NTRS)

Jones, William Henry

2005-01-01

The Project Integration Architecture (PIA) has been demonstrated in a single-machine C++ implementation prototype. The architecture is in the process of being migrated to a Common Object Request Broker Architecture (CORBA) implementation. The migration of the Foundation Layer interfaces is fundamentally complete. The implementation of the Application Layer infrastructure for that migration is reported. The Application Layer provides for distributed user identification and authentication, per-user/per-instance access controls, server administration, the formation of mutually-trusting application servers, a server locality protocol, and an ability to search for interface implementations through such trusted server networks.

Lithium-Ion Technology for Aerospace Applications- Advancing Battery Management Electronics

NASA Astrophysics Data System (ADS)

Gitzendanner, R.; Jones, E.; Deory, C.; Carmen, D.

2005-05-01

Lithium-ion technology offers a unique, weight and volume saving, solution to the power storage needs of space applications. With higher energy and power densities than conventional technologies, such as Nickel-Hydrogen (Ni-H) and Nickel/Cadmium (Ni- Cd), and comparable cycle life and reliability, Lithium-ion technology is gaining interest in many space applications. As the demand for Lithium-ion batteries with high reliability and long life increases, the need for battery management electronics, including individual cell balancing and monitoring, becomes apparent. With onboard electronics, the cells are monitored individually, and are protected from over charge or over discharge by way of integral protection circuitry. State of Charge, State of Health and other useful telemetry can also be calculated by the integrated electronics and reported to the application. Lab-based, and real-life, testing and use of these battery systems has shown the advantages of an integrated electronics package.

Monolithic microwave integrated circuits for sensors, radar, and communications systems; Proceedings of the Meeting, Orlando, FL, Apr. 2-4, 1991

NASA Technical Reports Server (NTRS)

Leonard, Regis F. (Editor); Bhasin, Kul B. (Editor)

1991-01-01

Consideration is given to MMICs for airborne phased arrays, monolithic GaAs integrated circuit millimeter wave imaging sensors, accurate design of multiport low-noise MMICs up to 20 GHz, an ultralinear low-noise amplifier technology for space communications, variable-gain MMIC module for space applications, a high-efficiency dual-band power amplifier for radar applications, a high-density circuit approach for low-cost MMIC circuits, coplanar SIMMWIC circuits, recent advances in monolithic phased arrays, and system-level integrated circuit development for phased-array antenna applications. Consideration is also given to performance enhancement in future communications satellites with MMIC technology insertion, application of Ka-band MMIC technology for an Orbiter/ACTS communications experiment, a space-based millimeter wave debris tracking radar, low-noise high-yield octave-band feedback amplifiers to 20 GHz, quasi-optical MESFET VCOs, and a high-dynamic-range mixer using novel balun structure.

Integrating open-source software applications to build molecular dynamics systems.

PubMed

Allen, Bruce M; Predecki, Paul K; Kumosa, Maciej

2014-04-05

Three open-source applications, NanoEngineer-1, packmol, and mis2lmp are integrated using an open-source file format to quickly create molecular dynamics (MD) cells for simulation. The three software applications collectively make up the open-source software (OSS) suite known as MD Studio (MDS). The software is validated through software engineering practices and is verified through simulation of the diglycidyl ether of bisphenol-a and isophorone diamine (DGEBA/IPD) system. Multiple simulations are run using the MDS software to create MD cells, and the data generated are used to calculate density, bulk modulus, and glass transition temperature of the DGEBA/IPD system. Simulation results compare well with published experimental and numerical results. The MDS software prototype confirms that OSS applications can be analyzed against real-world research requirements and integrated to create a new capability. Copyright © 2014 Wiley Periodicals, Inc.

A W-band integrated power module using MMIC MESFET power amplifiers and varactor doublers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ho, T.C.; Chen, Seng Woon; Pande, K.

1993-12-01

A high-performance integrated power module using U-band MMIC MESFET power amplifiers in conjunction with W-band MMIC high efficiency varactor doublers has been developed for millimeter-wave system applications. This paper presents the design, fabrication, and performance of this W-band integrated power module. Measured results of the complete integrated power module show an output power of 90 mW with an overall associated gain of 29.5 dB at 94 GHz. A saturated power of over 95 mW was also achieved. These results represent the highest reported power and gain at W-band using MESFET and varactor frequency doubling technologies. This integrated power module ismore » suitable for the future 94 GHz missile seeker applications.« less

Fragmentation of Thinking Structure's Students to Solving the Problem of Application Definite Integral in Area

ERIC Educational Resources Information Center

Wibawa, Kadek Adi; Nusantara, Toto; Subanji; Parta, I. Nengah

2017-01-01

This study aims to reveal the fragmentation of thinking structure's students in solving the problems of application definite integral in area. Fragmentation is a term on the computer (storage) that is highly relevant correlated with theoretical constructions that occur in the human brain (memory). Almost every student has a different way to…

Method and system of integrating information from multiple sources

DOEpatents

Alford, Francine A [Livermore, CA; Brinkerhoff, David L [Antioch, CA

2006-08-15

A system and method of integrating information from multiple sources in a document centric application system. A plurality of application systems are connected through an object request broker to a central repository. The information may then be posted on a webpage. An example of an implementation of the method and system is an online procurement system.

Integration of Study Abroad with Social Media Technologies and Decision-Making Applications

ERIC Educational Resources Information Center

Deans, P. Candace

2012-01-01

This article describes the design and delivery of a program, "Global Business in a Digital World." The program integrates the use of social media technologies and business applications in a series of courses that include short-term study abroad components that focus on emerging markets. The objectives are to: (1) provide additional…

Evaluation of a funded FY00 ITS integration component of the ITS deployment program "Traveler Information Integration Project" within the East Bay SMART Corridors project

DOT National Transportation Integrated Search

2004-12-07

The project originally was granted funding from the earmark in an application dated June 1, 2000. A revised application received approval on May 19, 2003 to reflect a different proposed implementation of the project, while still achieving the project...

Integration of a Computer Application in a First Year Accounting Curriculum: An Evaluation of Student Attitudes

ERIC Educational Resources Information Center

Laing, Gregory Kenneth; Perrin, Ronald William

2012-01-01

This paper presents the findings of a field study conducted to ascertain the perceptions of first year accounting students concerning the integration of computer applications in the accounting curriculum. The results indicate that both student cohorts perceived the computer as a valuable educational tool. The use of computers to enhance the…

Applicability of integrated cell culture quantitative PCR (ICC-qPCR) for the detection of infectious adenovirus type 2 in UV disinfection studies

EPA Science Inventory

Human adenovirus is relatively resistant to UV radiation and has been used as a conservative testing microbe for evaluations of UV disinfection systems as components of water treatment processes. In this study, we attempted to validate the applicability of integrated cell culture...

Integrated Spreadsheets as a Paradigm of Type II Technology Applications in Mathematics Teacher Education

ERIC Educational Resources Information Center

Abramovich, Sergei

2016-01-01

The paper presents the use of spreadsheets integrated with digital tools capable of symbolic computations and graphic constructions in a master's level capstone course for secondary mathematics teachers. Such use of spreadsheets is congruent with the Type II technology applications framework aimed at the development of conceptual knowledge in the…

System Integration - A Major Step toward Lab on a Chip

PubMed Central

2011-01-01

Microfluidics holds great promise to revolutionize various areas of biological engineering, such as single cell analysis, environmental monitoring, regenerative medicine, and point-of-care diagnostics. Despite the fact that intensive efforts have been devoted into the field in the past decades, microfluidics has not yet been adopted widely. It is increasingly realized that an effective system integration strategy that is low cost and broadly applicable to various biological engineering situations is required to fully realize the potential of microfluidics. In this article, we review several promising system integration approaches for microfluidics and discuss their advantages, limitations, and applications. Future advancements of these microfluidic strategies will lead toward translational lab-on-a-chip systems for a wide spectrum of biological engineering applications. PMID:21612614

ERP (enterprise resource planning) systems can streamline healthcare business functions.

PubMed

Jenkins, E K; Christenson, E

2001-05-01

Enterprise resource planning (ERP) software applications are designed to facilitate the systemwide integration of complex processes and functions across a large enterprise consisting of many internal and external constituents. Although most currently available ERP applications generally are tailored to the needs of the manufacturing industry, many large healthcare systems are investigating these applications. Due to the significant differences between manufacturing and patient care, ERP-based systems do not easily translate to the healthcare setting. In particular, the lack of clinical standardization impedes the use of ERP systems for clinical integration. Nonetheless, an ERP-based system can help a healthcare organization integrate many functions, including patient scheduling, human resources management, workload forecasting, and management of workflow, that are not directly dependent on clinical decision making.

Application of a high-energy-density permanent magnet material in underwater systems

NASA Astrophysics Data System (ADS)

Cho, C. P.; Egan, C.; Krol, W. P.

1996-06-01

This paper addresses the application of high-energy-density permanent magnet (PM) technology to (1) the brushless, axial-field PM motor and (2) the integrated electric motor/pump system for under-water applications. Finite-element analysis and lumped parameter magnetic circuit analysis were used to calculate motor parameters and performance characteristics and to conduct tradeoff studies. Compact, efficient, reliable, and quiet underwater systems are attainable with the development of high-energy-density PM material, power electronic devices, and power integrated-circuit technology.

Functional Integration

NASA Astrophysics Data System (ADS)

Cartier, Pierre; DeWitt-Morette, Cecile

2006-11-01

Acknowledgements; List symbols, conventions, and formulary; Part I. The Physical and Mathematical Environment: 1. The physical and mathematical environment; Part II. Quantum Mechanics: 2. First lesson: gaussian integrals; 3. Selected examples; 4. Semiclassical expansion: WKB; 5. Semiclassical expansion: beyond WKB; 6. Quantum dynamics: path integrals and operator formalism; Part III. Methods from Differential Geometry: 7. Symmetries; 8. Homotopy; 9. Grassmann analysis: basics; 10. Grassmann analysis: applications; 11. Volume elements, divergences, gradients; Part IV. Non-Gaussian Applications: 12. Poisson processes in physics; 13. A mathematical theory of Poisson processes; 14. First exit time: energy problems; Part V. Problems in Quantum Field Theory: 15. Renormalization 1: an introduction; 16. Renormalization 2: scaling; 17. Renormalization 3: combinatorics; 18. Volume elements in quantum field theory Bryce DeWitt; Part VI. Projects: 19. Projects; Appendix A. Forward and backward integrals: spaces of pointed paths; Appendix B. Product integrals; Appendix C. A compendium of gaussian integrals; Appendix D. Wick calculus Alexander Wurm; Appendix E. The Jacobi operator; Appendix F. Change of variables of integration; Appendix G. Analytic properties of covariances; Appendix H. Feynman's checkerboard; Bibliography; Index.

Functional Integration

NASA Astrophysics Data System (ADS)

Cartier, Pierre; DeWitt-Morette, Cecile

2010-06-01

Acknowledgements; List symbols, conventions, and formulary; Part I. The Physical and Mathematical Environment: 1. The physical and mathematical environment; Part II. Quantum Mechanics: 2. First lesson: gaussian integrals; 3. Selected examples; 4. Semiclassical expansion: WKB; 5. Semiclassical expansion: beyond WKB; 6. Quantum dynamics: path integrals and operator formalism; Part III. Methods from Differential Geometry: 7. Symmetries; 8. Homotopy; 9. Grassmann analysis: basics; 10. Grassmann analysis: applications; 11. Volume elements, divergences, gradients; Part IV. Non-Gaussian Applications: 12. Poisson processes in physics; 13. A mathematical theory of Poisson processes; 14. First exit time: energy problems; Part V. Problems in Quantum Field Theory: 15. Renormalization 1: an introduction; 16. Renormalization 2: scaling; 17. Renormalization 3: combinatorics; 18. Volume elements in quantum field theory Bryce DeWitt; Part VI. Projects: 19. Projects; Appendix A. Forward and backward integrals: spaces of pointed paths; Appendix B. Product integrals; Appendix C. A compendium of gaussian integrals; Appendix D. Wick calculus Alexander Wurm; Appendix E. The Jacobi operator; Appendix F. Change of variables of integration; Appendix G. Analytic properties of covariances; Appendix H. Feynman's checkerboard; Bibliography; Index.

Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data.

PubMed

Kamboj, Atul; Hallwirth, Claus V; Alexander, Ian E; McCowage, Geoffrey B; Kramer, Belinda

2017-06-17

The analysis of viral vector genomic integration sites is an important component in assessing the safety and efficiency of patient treatment using gene therapy. Alongside this clinical application, integration site identification is a key step in the genetic mapping of viral elements in mutagenesis screens that aim to elucidate gene function. We have developed a UNIX-based vector integration site analysis pipeline (Ub-ISAP) that utilises a UNIX-based workflow for automated integration site identification and annotation of both single and paired-end sequencing reads. Reads that contain viral sequences of interest are selected and aligned to the host genome, and unique integration sites are then classified as transcription start site-proximal, intragenic or intergenic. Ub-ISAP provides a reliable and efficient pipeline to generate large datasets for assessing the safety and efficiency of integrating vectors in clinical settings, with broader applications in cancer research. Ub-ISAP is available as an open source software package at https://sourceforge.net/projects/ub-isap/ .

A holistic passive integrative sampling approach for assessing the presence and potential impacts of waterborne environmental contaminants

USGS Publications Warehouse

Petty, J.D.; Huckins, J.N.; Alvarez, D.A.; Brumbaugh, W. G.; Cranor, W.L.; Gale, R.W.; Rastall, A.C.; Jones-Lepp, T. L.; Leiker, T.J.; Rostad, C. E.; Furlong, E.T.

2004-01-01

As an integral part of our continuing research in environmental quality assessment approaches, we have developed a variety of passive integrative sampling devices widely applicable for use in defining the presence and potential impacts of a broad array of contaminants. The semipermeable membrane device has gained widespread use for sampling hydrophobic chemicals from water and air, the polar organic chemical integrative sampler is applicable for sequestering waterborne hydrophilic organic chemicals, the stabilized liquid membrane device is used to integratively sample waterborne ionic metals, and the passive integrative mercury sampler is applicable for sampling vapor phase or dissolved neutral mercury species. This suite of integrative samplers forms the basis for a new passive sampling approach for assessing the presence and potential toxicological significance of a broad spectrum of environmental contaminants. In a proof-of-concept study, three of our four passive integrative samplers were used to assess the presence of a wide variety of contaminants in the waters of a constructed wetland, and to determine the effectiveness of the constructed wetland in removing contaminants. The wetland is used for final polishing of secondary-treatment municipal wastewater and the effluent is used as a source of water for a state wildlife area. Numerous contaminants, including organochlorine pesticides, polycyclic aromatic hydrocarbons, organophosphate pesticides, and pharmaceutical chemicals (e.g., ibuprofen, oxindole, etc.) were detected in the wastewater. Herein we summarize the results of the analysis of the field-deployed samplers and demonstrate the utility of this holistic approach.

Design and implementation of space physics multi-model application integration based on web

NASA Astrophysics Data System (ADS)

Jiang, Wenping; Zou, Ziming

With the development of research on space environment and space science, how to develop network online computing environment of space weather, space environment and space physics models for Chinese scientific community is becoming more and more important in recent years. Currently, There are two software modes on space physics multi-model application integrated system (SPMAIS) such as C/S and B/S. the C/S mode which is traditional and stand-alone, demands a team or workshop from many disciplines and specialties to build their own multi-model application integrated system, that requires the client must be deployed in different physical regions when user visits the integrated system. Thus, this requirement brings two shortcomings: reducing the efficiency of researchers who use the models to compute; inconvenience of accessing the data. Therefore, it is necessary to create a shared network resource access environment which could help users to visit the computing resources of space physics models through the terminal quickly for conducting space science research and forecasting spatial environment. The SPMAIS develops high-performance, first-principles in B/S mode based on computational models of the space environment and uses these models to predict "Space Weather", to understand space mission data and to further our understanding of the solar system. the main goal of space physics multi-model application integration system (SPMAIS) is to provide an easily and convenient user-driven online models operating environment. up to now, the SPMAIS have contained dozens of space environment models , including international AP8/AE8 IGRF T96 models and solar proton prediction model geomagnetic transmission model etc. which are developed by Chinese scientists. another function of SPMAIS is to integrate space observation data sets which offers input data for models online high-speed computing. In this paper, service-oriented architecture (SOA) concept that divides system into independent modules according to different business needs is applied to solve the problem of the independence of the physical space between multiple models. The classic MVC(Model View Controller) software design pattern is concerned to build the architecture of space physics multi-model application integrated system. The JSP+servlet+javabean technology is used to integrate the web application programs of space physics multi-model. It solves the problem of multi-user requesting the same job of model computing and effectively balances each server computing tasks. In addition, we also complete follow tasks: establishing standard graphical user interface based on Java Applet application program; Designing the interface between model computing and model computing results visualization; Realizing three-dimensional network visualization without plug-ins; Using Java3D technology to achieve a three-dimensional network scene interaction; Improved ability to interact with web pages and dynamic execution capabilities, including rendering three-dimensional graphics, fonts and color control. Through the design and implementation of the SPMAIS based on Web, we provide an online computing and application runtime environment of space physics multi-model. The practical application improves that researchers could be benefit from our system in space physics research and engineering applications.

Highly integrated optical phased arrays: photonic integrated circuits for optical beam shaping and beam steering

NASA Astrophysics Data System (ADS)

Heck, Martijn J. R.

2017-01-01

Technologies for efficient generation and fast scanning of narrow free-space laser beams find major applications in three-dimensional (3D) imaging and mapping, like Lidar for remote sensing and navigation, and secure free-space optical communications. The ultimate goal for such a system is to reduce its size, weight, and power consumption, so that it can be mounted on, e.g. drones and autonomous cars. Moreover, beam scanning should ideally be done at video frame rates, something that is beyond the capabilities of current opto-mechanical systems. Photonic integrated circuit (PIC) technology holds the promise of achieving low-cost, compact, robust and energy-efficient complex optical systems. PICs integrate, for example, lasers, modulators, detectors, and filters on a single piece of semiconductor, typically silicon or indium phosphide, much like electronic integrated circuits. This technology is maturing fast, driven by high-bandwidth communications applications, and mature fabrication facilities. State-of-the-art commercial PICs integrate hundreds of elements, and the integration of thousands of elements has been shown in the laboratory. Over the last few years, there has been a considerable research effort to integrate beam steering systems on a PIC, and various beam steering demonstrators based on optical phased arrays have been realized. Arrays of up to thousands of coherent emitters, including their phase and amplitude control, have been integrated, and various applications have been explored. In this review paper, I will present an overview of the state of the art of this technology and its opportunities, illustrated by recent breakthroughs.

Organizing integrated care in a university hospital: application of a conceptual framework

PubMed Central

Axelsson, Runo; Axelsson, Susanna Bihari; Gustafsson, Jeppe; Seemann, Janne

2014-01-01

Background and aim As a result of New Public Management, a number of industrial models of quality management have been implemented in health care, mainly in hospitals. At the same time, the concept of integrated care has been developed within other parts of the health sector. The aim of the article is to discuss the relevance of integrated care for hospitals. Theory and methods The discussion is based on application of a conceptual framework outlining a number of organizational models of integrated care. These models are illustrated in a case study of a Danish university hospital implementing a new organization for improving the patient flows of the hospital. The study of the reorganization is based mainly on qualitative data from individual and focus group interviews. Results The new organization of the university hospital can be regarded as a matrix structure combining a vertical integration of clinical departments with a horizontal integration of patient flows. This structure has elements of both interprofessional and interorganizational integration. A strong focus on teamwork, meetings and information exchange is combined with elements of case management and co-location. Conclusions It seems that integrated care can be a relevant concept for a hospital. Although the organizational models may challenge established professional boundaries and financial control systems, this concept can be a more promising way to improve the quality of care than the industrial models that have been imported into health care. This application of the concept may also contribute to widen the field of integrated care. PMID:24966806

IPAD applications to the design, analysis, and/or machining of aerospace structures. [Integrated Program for Aerospace-vehicle Design

NASA Technical Reports Server (NTRS)

Blackburn, C. L.; Dovi, A. R.; Kurtze, W. L.; Storaasli, O. O.

1981-01-01

A computer software system for the processing and integration of engineering data and programs, called IPAD (Integrated Programs for Aerospace-Vehicle Design), is described. The ability of the system to relieve the engineer of the mundane task of input data preparation is demonstrated by the application of a prototype system to the design, analysis, and/or machining of three simple structures. Future work to further enhance the system's automated data handling and ability to handle larger and more varied design problems are also presented.

Application of integrated fluid-thermal-structural analysis methods

NASA Technical Reports Server (NTRS)

Wieting, Allan R.; Dechaumphai, Pramote; Bey, Kim S.; Thornton, Earl A.; Morgan, Ken

1988-01-01

Hypersonic vehicles operate in a hostile aerothermal environment which has a significant impact on their aerothermostructural performance. Significant coupling occurs between the aerodynamic flow field, structural heat transfer, and structural response creating a multidisciplinary interaction. Interfacing state-of-the-art disciplinary analysis methods is not efficient, hence interdisciplinary analysis methods integrated into a single aerothermostructural analyzer are needed. The NASA Langley Research Center is developing such methods in an analyzer called LIFTS (Langley Integrated Fluid-Thermal-Structural) analyzer. The evolution and status of LIFTS is reviewed and illustrated through applications.

Semiconductor Cubing

NASA Technical Reports Server (NTRS)

1996-01-01

Through Goddard Space Flight Center and Jet Propulsion Laboratory Small Business Innovation Research contracts, Irvine Sensors developed a three-dimensional memory system for a spaceborne data recorder and other applications for NASA. From these contracts, the company created the Memory Short Stack product, a patented technology for stacking integrated circuits that offers higher processing speeds and levels of integration, and lower power requirements. The product is a three-dimensional semiconductor package in which dozens of integrated circuits are stacked upon each other to form a cube. The technology is being used in various computer and telecommunications applications.

Integrated Speed Limiter and Fatigue Analyzer System

NASA Astrophysics Data System (ADS)

Pranoto, Hadi; Leman, A. M.; Wahab, Abdi; Sebayang, Darwin

2018-03-01

The traffic accident increase in line with the growth of the vehicle, so the safety system must be developed to decrease the accident. This paper will purpose the integrated between speed limiter and fatigue analyser to improve the safety for vehicle, and also to analyse if there is an accident. The device and the software or application are developed and then integrated into one system. The testing held to prove the integrated between device and the application, and it show the system can work well. The next improvement for this system can be developing the server to collect data from internet, so the driver and the vehicle owner can monitor the system by internet.

Solving the Integral of Quadratic Forms of Covariance Matrices for Applications in Polarimetric Radar Imagery

NASA Astrophysics Data System (ADS)

Marino, Armando; Hajnsek, Irena

2015-04-01

In this work, the solution of quadratic forms with special application to polarimetric and interferometric covariance matrices is investigated. An analytical solution for the integral of a single quadratic form is derived. Additionally, the integral of the Pol-InSAR coherence (expressed as combination of quadratic forms) is investigated. An approximation for such integral is proposed and defined as Trace coherence. Such approximation is tested on real data to verify that the error is acceptable. The trace coherence can be used for tackle problems related to change detection. Moreover, the use of the Trace coherence in model inversion (as for the RVoG three stage inversion) will be investigated in the future.

DICOM image quantification secondary capture (DICOM IQSC) integrated with numeric results, regions, and curves: implementation and applications in nuclear medicine

NASA Astrophysics Data System (ADS)

Cao, Xinhua; Xu, Xiaoyin; Voss, Stephan

2017-03-01

In this paper, we describe an enhanced DICOM Secondary Capture (SC) that integrates Image Quantification (IQ) results, Regions of Interest (ROIs), and Time Activity Curves (TACs) with screen shots by embedding extra medical imaging information into a standard DICOM header. A software toolkit of DICOM IQSC has been developed to implement the SC-centered information integration of quantitative analysis for routine practice of nuclear medicine. Primary experiments show that the DICOM IQSC method is simple and easy to implement seamlessly integrating post-processing workstations with PACS for archiving and retrieving IQ information. Additional DICOM IQSC applications in routine nuclear medicine and clinic research are also discussed.

Silicon/III-V laser with super-compact diffraction grating for WDM applications in electronic-photonic integrated circuits.

PubMed

Wang, Yadong; Wei, Yongqiang; Huang, Yingyan; Tu, Yongming; Ng, Doris; Lee, Cheewei; Zheng, Yunan; Liu, Boyang; Ho, Seng-Tiong

2011-01-31

We have demonstrated a heterogeneously integrated III-V-on-Silicon laser based on an ultra-large-angle super-compact grating (SCG). The SCG enables single-wavelength operation due to its high-spectral-resolution aberration-free design, enabling wavelength division multiplexing (WDM) applications in Electronic-Photonic Integrated Circuits (EPICs). The SCG based Si/III-V laser is realized by fabricating the SCG on silicon-on-insulator (SOI) substrate. Optical gain is provided by electrically pumped heterogeneous integrated III-V material on silicon. Single-wavelength lasing at 1550 nm with an output power of over 2 mW and a lasing threshold of around 150 mA were achieved.

[Public Health as an Applied, Multidisciplinary Subject: Is Research-Based Learning the Answer to Challenges in Learning and Teaching?

PubMed

Gerhardus, A; Schilling, I; Voss, M

2017-03-01

Public health education aims at enabling students to deal with complex health-related challenges using appropriate methods based on sound theoretical understanding. Virtually all health-related problems in science and practice require the involvement of different disciplines. However, the necessary interdisciplinarity is only partly reflected in the curricula of public health courses. Also theories, methods, health topics, and their application are often taught side-by-side and not together. For students, it can become an insurmountable challenge to integrate the different disciplines ("horizontal integration") and theories, methods, health topics, and their application ("vertical integration"). This situation is specific for education in public health but is representative for other interdisciplinary fields as well. Several approaches are available to achieve the horizontal integration of different disciplines and vertical integration of theories, methods, health topics, and their application. A curriculum that is structured by topics, rather than disciplines might be more successful in integrating different disciplines. Vertical integration can be achieved by research-based learning. Research-based learning places a student-led research project at the centre of teaching. Students choose a topic and a research question, raise their own questions for theories and methods and will hopefully cross the seeming chasm between science and practice. Challenges of research-based learning are enhanced demands on students, teachers and curriculum design. © Georg Thieme Verlag KG Stuttgart · New York.

49 CFR 244.19 - Disposition.

Code of Federal Regulations, 2014 CFR

2014-10-01

... TRANSPORTATION REGULATIONS ON SAFETY INTEGRATION PLANS GOVERNING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL Safety Integration Plans § 244.19 Disposition. (a) Standard of review. FRA reviews an applicant's Safety Integration Plan, and any amendments thereto, to determine whether it provides a...

49 CFR 244.19 - Disposition.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TRANSPORTATION REGULATIONS ON SAFETY INTEGRATION PLANS GOVERNING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL Safety Integration Plans § 244.19 Disposition. (a) Standard of review. FRA reviews an applicant's Safety Integration Plan, and any amendments thereto, to determine whether it provides a...

49 CFR 244.19 - Disposition.

Code of Federal Regulations, 2013 CFR

2013-10-01

... TRANSPORTATION REGULATIONS ON SAFETY INTEGRATION PLANS GOVERNING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL Safety Integration Plans § 244.19 Disposition. (a) Standard of review. FRA reviews an applicant's Safety Integration Plan, and any amendments thereto, to determine whether it provides a...

49 CFR 244.19 - Disposition.

Code of Federal Regulations, 2012 CFR

2012-10-01

... TRANSPORTATION REGULATIONS ON SAFETY INTEGRATION PLANS GOVERNING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL Safety Integration Plans § 244.19 Disposition. (a) Standard of review. FRA reviews an applicant's Safety Integration Plan, and any amendments thereto, to determine whether it provides a...

49 CFR 244.19 - Disposition.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TRANSPORTATION REGULATIONS ON SAFETY INTEGRATION PLANS GOVERNING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL Safety Integration Plans § 244.19 Disposition. (a) Standard of review. FRA reviews an applicant's Safety Integration Plan, and any amendments thereto, to determine whether it provides a...

Molecular and functional properties of gelatin from the skin of unicorn leatherjacket as affected by extracting temperatures.

PubMed

Kaewruang, Phanngam; Benjakul, Soottawat; Prodpran, Thummanoon

2013-06-01

Gelatins extracted from the skin of unicorn leatherjacket at different temperatures (45, 55, 65 and 75°C) in the presence and the absence of soybean trypsin inhibitor (SBTI; 100 units/g pretreated skin) for 12h were characterised. In general, the addition of SBTI resulted in the lower yield, regardless of extraction temperature. Higher yield was obtained when higher extraction temperature was used (P<0.05). Gelatin from skin extracted at 75°C in the absence of SBTI showed the highest yield (10.66 ± 0.41%) (based on dry weight). The highest α-amino group content was observed in gelatin extracted at 55°C without SBTI incorporated. The band intensity of β-chain and α-chains increased as the extraction temperature increased, particularly above 55°C. Gelatin extracted at 65°C with and without SBTI incorporation exhibited the highest gel strength (178.00 ± 7.50 g and 170.47 ± 1.30 g, respectively). FTIR spectra indicated that a greater loss of molecular order of triple helix with a higher degradation was found in gelatin extracted at 55°C in the absence SBTI. Gelatin extracted at 65°C, either with or without SBTI, had the highest EAI and ESI with high foam expansion and stability. Thus, the extraction of gelatin from the skin of unicorn leatherjacket at temperature sufficiently high could render the gelatin with less degradation. Copyright © 2012 Elsevier Ltd. All rights reserved.

Physiochemical and functional properties of tiger puffer (Takifugu rubripes) skin gelatin as affected by extraction conditions.

PubMed

Pan, Jinfeng; Li, Qi; Jia, Hui; Xia, Lining; Jin, Wengang; Shang, Meijun; Xu, Chang; Dong, Xiuping

2018-04-01

The study investigated physiochemical and functional properties of gelatins from tiger puffer skin (GTPS) extracted with warm-water method at 45, 55 and 65°C for 3, 6 and 12h. GTPS45 exhibited strong γ-, β-, α1- and α2-chains, but they faded with the presence of fragments (<80KDa) in other GTPS. As the increase of temperature and time, amide I and A were shifted to higher wavenumber and their amplitudes in GTPS65-12 decreased. Lightness declined while redness and yellowness were enhanced. Gel strength was in a range of 144.5-79.8g, where it of GTPS45-3 was the highest while it of GTPS65-12 was the lowest (p<0.05), coincided with the longer relaxation time of T 22 for immobilized water. Decline in gelling and melting temperature was observed when temperature and time increased. EAI and ESI increased as time prolonged or temperature climbed (p<0.05), in agreement with the form of emulsion droplet by microscopy. Both category and level of volatile compounds increased GTPS65-12 and 55-12 compared with those in GTPS45-12. Results suggest that temperature and time greatly affect the properties of GTPS. To ensure good properties, GTPS should be extracted at a temperature of 45-55°C for less than 12h. Copyright © 2017 Elsevier B.V. All rights reserved.

Compact multispectral photodiode arrays using micropatterned dichroic filters

NASA Astrophysics Data System (ADS)

Chandler, Eric V.; Fish, David E.

2014-05-01

The next generation of multispectral instruments requires significant improvements in both spectral band customization and portability to support the widespread deployment of application-specific optical sensors. The benefits of spectroscopy are well established for numerous applications including biomedical instrumentation, industrial sorting and sensing, chemical detection, and environmental monitoring. In this paper, spectroscopic (and by extension hyperspectral) and multispectral measurements are considered. The technology, tradeoffs, and application fits of each are evaluated. In the majority of applications, monitoring 4-8 targeted spectral bands of optimized wavelength and bandwidth provides the necessary spectral contrast and correlation. An innovative approach integrates precision spectral filters at the photodetector level to enable smaller sensors, simplify optical designs, and reduce device integration costs. This method supports user-defined spectral bands to create application-specific sensors in a small footprint with scalable cost efficiencies. A range of design configurations, filter options and combinations are presented together with typical applications ranging from basic multi-band detection to stringent multi-channel fluorescence measurement. An example implementation packages 8 narrowband silicon photodiodes into a 9x9mm ceramic LCC (leadless chip carrier) footprint. This package is designed for multispectral applications ranging from portable color monitors to purpose- built OEM industrial and scientific instruments. Use of an eight-channel multispectral photodiode array typically eliminates 10-20 components from a device bill-of-materials (BOM), streamlining the optical path and shrinking the footprint by 50% or more. A stepwise design approach for multispectral sensors is discussed - including spectral band definition, optical design tradeoffs and constraints, and device integration from prototype through scalable volume production. Additional customization options are explored for application-specific OEM sensors integrated into portable devices using multispectral photodiode arrays.

Fractional quantum integral operator with general kernels and applications

NASA Astrophysics Data System (ADS)

Babakhani, Azizollah; Neamaty, Abdolali; Yadollahzadeh, Milad; Agahi, Hamzeh

In this paper, we first introduce the concept of fractional quantum integral with general kernels, which generalizes several types of fractional integrals known from the literature. Then we give more general versions of some integral inequalities for this operator, thus generalizing some previous results obtained by many researchers.2,8,25,29,30,36

Vertical integration of basic science in final year of medical education

PubMed Central

Rajan, Sudha Jasmine; Jacob, Tripti Meriel; Sathyendra, Sowmya

2016-01-01

Background: Development of health professionals with ability to integrate, synthesize, and apply knowledge gained through medical college is greatly hampered by the system of delivery that is compartmentalized and piecemeal. There is a need to integrate basic sciences with clinical teaching to enable application in clinical care. Aim: To study the benefit and acceptance of vertical integration of basic science in final year MBBS undergraduate curriculum. Materials and Methods: After Institutional Ethics Clearance, neuroanatomy refresher classes with clinical application to neurological diseases were held as part of the final year posting in two medical units. Feedback was collected. Pre- and post-tests which tested application and synthesis were conducted. Summative assessment was compared with the control group of students who had standard teaching in other two medical units. In-depth interview was conducted on 2 willing participants and 2 teachers who did neurology bedside teaching. Results: Majority (>80%) found the classes useful and interesting. There was statistically significant improvement in the post-test scores. There was a statistically significant difference between the intervention and control groups' scores during summative assessment (76.2 vs. 61.8 P < 0.01). Students felt that it reinforced, motivated self-directed learning, enabled correlations, improved understanding, put things in perspective, gave confidence, aided application, and enabled them to follow discussions during clinical teaching. Conclusion: Vertical integration of basic science in final year was beneficial and resulted in knowledge gain and improved summative scores. The classes were found to be useful, interesting and thought to help in clinical care and application by majority of students. PMID:27563584

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy.

PubMed

Meng, Hong-Min; Liu, Hui; Kuai, Hailan; Peng, Ruizi; Mo, Liuting; Zhang, Xiao-Bing

2016-05-03

The combination of nanostructures with biomolecules leading to the generation of functional nanosystems holds great promise for biotechnological and biomedical applications. As a naturally occurring biomacromolecule, DNA exhibits excellent biocompatibility and programmability. Also, scalable synthesis can be readily realized through automated instruments. Such unique properties, together with Watson-Crick base-pairing interactions, make DNA a particularly promising candidate to be used as a building block material for a wide variety of nanostructures. In the past few decades, various DNA nanostructures have been developed, including one-, two- and three-dimensional nanomaterials. Aptamers are single-stranded DNA or RNA molecules selected by Systematic Evolution of Ligands by Exponential Enrichment (SELEX), with specific recognition abilities to their targets. Therefore, integrating aptamers into DNA nanostructures results in powerful tools for biosensing and bioimaging applications. Furthermore, owing to their high loading capability, aptamer-modified DNA nanostructures have also been altered to play the role of drug nanocarriers for in vivo applications and targeted cancer therapy. In this review, we summarize recent progress in the design of aptamers and related DNA molecule-integrated DNA nanostructures as well as their applications in biosensing, bioimaging and cancer therapy. To begin with, we first introduce the SELEX technology. Subsequently, the methodologies for the preparation of aptamer-integrated DNA nanostructures are presented. Then, we highlight their applications in biosensing and bioimaging for various targets, as well as targeted cancer therapy applications. Finally, we discuss several challenges and further opportunities in this emerging field.

Navigation and Elctro-Optic Sensor Integration Technology for Fusion of Imagery and Digital Mapping Products

DTIC Science & Technology

1999-08-01

Electro - Optic Sensor Integration Technology (NEOSIT) software application. The design is highly modular and based on COTS tools to facilitate integration with sensors, navigation and digital data sources already installed on different host

Using Scholarship To Integrate Teaching and Research.

ERIC Educational Resources Information Center

McKenna, Judy; Bickle, Marianne; Carroll, Jan B.

2002-01-01

A merchandising course illustrates Boyer's four stages of scholarship--discovery, integration, application, and teaching--and adds a fifth: outcome (production of a scholarly product). The model is a means of integrating teaching and research in family and consumer sciences education. (SK)

49 CFR 244.17 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... TRANSPORTATION REGULATIONS ON SAFETY INTEGRATION PLANS GOVERNING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL Safety Integration Plans § 244.17 Procedures. (a) Each applicant shall file one original of a proposed Safety Integration Plan with the Associate Administrator for Safety, FRA, 1200 New...

49 CFR 244.17 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TRANSPORTATION REGULATIONS ON SAFETY INTEGRATION PLANS GOVERNING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL Safety Integration Plans § 244.17 Procedures. (a) Each applicant shall file one original of a proposed Safety Integration Plan with the Associate Administrator for Safety, FRA, 1200 New...

Ready, Set, Integrate!

ERIC Educational Resources Information Center

McCombs, John

2003-01-01

Describes how the American Embassy School (AES) in New Delhi, India achieved school-wide technology integration. Discusses development of a new network; beginning to mentor; organizing the Technology Integration Plan (TIP) by software application; implementing the plan; assessing progress; and results, which overall, were positive. (AEF)

49 CFR 244.17 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TRANSPORTATION REGULATIONS ON SAFETY INTEGRATION PLANS GOVERNING RAILROAD CONSOLIDATIONS, MERGERS, AND ACQUISITIONS OF CONTROL Safety Integration Plans § 244.17 Procedures. (a) Each applicant shall file one original of a proposed Safety Integration Plan with the Associate Administrator for Safety, FRA, 1200 New...

Technology Integration Experiences of Teachers

ERIC Educational Resources Information Center

Çoklar, Ahmet Naci; Yurdakul, Isil Kabakçi

2017-01-01

Teachers are important providers of educational sustainability. Teachers' ability to adapt themselves to rapidly developing technologies applicable to learning environments is connected with technology integration. The purpose of this study is to investigate teachers' technology integration experiences in the course of learning and teaching…

[Formula: see text]-Contraction in terms of measure of noncompactness with application for nonlinear integral equations.

PubMed

Nikbakhtsarvestani, Farzaneh; Vaezpour, S Mansour; Asadi, Mehdi

2017-01-01

In this paper, some new generalization of Darbo's fixed point theorem is proved by using a [Formula: see text]-contraction in terms of a measure of noncompactness. Our result extends to obtaining a common fixed point for a pair of compatible mappings. The paper contains an application for nonlinear integral equations as well.

Application of a Reference Framework for Integration of Web Resources in Dotlrn--Case Study of Physics--Topic: Waves

ERIC Educational Resources Information Center

Gomez, Fabinton Sotelo; Ordóñez, Armando

2016-01-01

Previously a framework for integrating web resources providing educational services in dotLRN was presented. The present paper describes the application of this framework in a rural school in Cauca--Colombia. The case study includes two web resources about the topic of waves (physics) which is oriented in secondary education. Web classes and…

Applicability of integrated cell culture reverse transcriptase quantitative PCR (ICC-RTqPCR) for the simultaneous detection of the four human enteric enterovirus species in disinfection studies

EPA Science Inventory

A newly developed integrated cell culture reverse transcriptase quantitative PCR (ICC-RTqPCR) method and its applicability in UV disinfection studies is described. This method utilizes a singular cell culture system coupled with four RTqPCR assays to detect infectious serotypes t...

Application of boundary integral equations to elastoplastic problems

NASA Technical Reports Server (NTRS)

Mendelson, A.; Albers, L. U.

1975-01-01

The application of boundary integral equations to elastoplastic problems is reviewed. Details of the analysis as applied to torsion problems and to plane problems is discussed. Results are presented for the elastoplastic torsion of a square cross section bar and for the plane problem of notched beams. A comparison of different formulations as well as comparisons with experimental results are presented.

Integrating Competency-Based Instruction into Vocational Education. Microcomputer Applications for Vocational Teachers: A Competency-Based Approach--Book B.

ERIC Educational Resources Information Center

Roth, Gene; Tesolowski, Dennis

This handbook is the second in a series of five competency-based resource guides on microcomputer applications for vocational teachers. The seven units of instruction in this handbook are concerned with the content of the eight competencies included in the category, "Integrating Competency-Based Instruction into Vocational Education." Units are…

New ultraportable display technology and applications

NASA Astrophysics Data System (ADS)

Alvelda, Phillip; Lewis, Nancy D.

1998-08-01

MicroDisplay devices are based on a combination of technologies rooted in the extreme integration capability of conventionally fabricated CMOS active-matrix liquid crystal display substrates. Customized diffraction grating and optical distortion correction technology for lens-system compensation allow the elimination of many lenses and systems-level components. The MicroDisplay Corporation's miniature integrated information display technology is rapidly leading to many new defense and commercial applications. There are no moving parts in MicroDisplay substrates, and the fabrication of the color generating gratings, already part of the CMOS circuit fabrication process, is effectively cost and manufacturing process-free. The entire suite of the MicroDisplay Corporation's technologies was devised to create a line of application- specific integrated circuit single-chip display systems with integrated computing, memory, and communication circuitry. Next-generation portable communication, computer, and consumer electronic devices such as truly portable monitor and TV projectors, eyeglass and head mounted displays, pagers and Personal Communication Services hand-sets, and wristwatch-mounted video phones are among the may target commercial markets for MicroDisplay technology. Defense applications range from Maintenance and Repair support, to night-vision systems, to portable projectors for mobile command and control centers.

Integrated structural health monitoring

NASA Astrophysics Data System (ADS)

Farrar, Charles R.; Sohn, Hoon; Fugate, Michael L.; Czarnecki, Jerry J.

2001-07-01

Structural health monitoring is the implementation of a damage detection strategy for aerospace, civil and mechanical engineering infrastructure. Typical damage experienced by this infrastructure might be the development of fatigue cracks, degradation of structural connections, or bearing wear in rotating machinery. The goal of the research effort reported herein is to develop a robust and cost-effective structural health monitoring solution by integrating and extending technologies from various engineering and information technology disciplines. It is the author's opinion that all structural health monitoring systems must be application specific. Therefore, a specific application, monitoring welded moment resisting steel frame connections in structures subjected to seismic excitation, is described along with the motivation for choosing this application. The structural health monitoring solution for this application will integrate structural dynamics, wireless data acquisition, local actuation, micro-electromechanical systems (MEMS) technology, and statistical pattern recognition algorithms. The proposed system is based on an assessment of the deficiencies associated with many current structural health monitoring technologies including past efforts by the authors. This paper provides an example of the integrated approach to structural health monitoring being undertaken at Los Alamos National Laboratory and summarizes progress to date on various aspects of the technology development.

Integrating in silico models to enhance predictivity for developmental toxicity.

PubMed

Marzo, Marco; Kulkarni, Sunil; Manganaro, Alberto; Roncaglioni, Alessandra; Wu, Shengde; Barton-Maclaren, Tara S; Lester, Cathy; Benfenati, Emilio

2016-08-31

Application of in silico models to predict developmental toxicity has demonstrated limited success particularly when employed as a single source of information. It is acknowledged that modelling the complex outcomes related to this endpoint is a challenge; however, such models have been developed and reported in the literature. The current study explored the possibility of integrating the selected public domain models (CAESAR, SARpy and P&G model) with the selected commercial modelling suites (Multicase, Leadscope and Derek Nexus) to assess if there is an increase in overall predictive performance. The results varied according to the data sets used to assess performance which improved upon model integration relative to individual models. Moreover, because different models are based on different specific developmental toxicity effects, integration of these models increased the applicable chemical and biological spaces. It is suggested that this approach reduces uncertainty associated with in silico predictions by achieving a consensus among a battery of models. The use of tools to assess the applicability domain also improves the interpretation of the predictions. This has been verified in the case of the software VEGA, which makes freely available QSAR models with a measurement of the applicability domain. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Manufacturing technology of integrated textile-based sensor networks for in situ monitoring applications of composite wind turbine blades

NASA Astrophysics Data System (ADS)

Haentzsche, Eric; Mueller, Ralf; Huebner, Matthias; Ruder, Tristan; Unger, Reimar; Nocke, Andreas; Cherif, Chokri

2016-10-01

Based on in situ strain sensors consisting of piezo-resistive carbon filament yarns (CFYs), which have been successfully integrated into textile reinforcement structures during their textile-technological manufacturing process, a continuous load of fibre-reinforced plastic (FRP) components has been realised. These sensors are also suitable for structural health monitoring (SHM) applications. The two-dimensional sensor layout is made feasible by the usage of a modular warp yarn path manipulation unit. Using a functional model of a small wind turbine blade in thermoset composite design, the sensor function for basic SHM applications (e.g. static load monitoring) are demonstrated. Any mechanical loads along the pressure or suction side of the wind turbine blade can be measured and calculated via a correlative change in resistance of the CFYs within the textile reinforcement plies. Performing quasi-static load tests on both tensile specimen and full-scale wind turbine blade, elementary results have been obtained concerning electro-mechanical behaviour and spatial resolution of global and even local static stresses according to the CFY sensor integration length. This paper demonstrates the great potential of textile-based and textile-technological integrated sensors in reinforcement structures for future SHM applications of FRPs.

Application of the Yoshida-Ruth Techniques to Implicit Integration and Multi-Map Explicit Integration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forest, E.; Bengtsson, J.; Reusch, M.F.

1991-04-01

The full power of Yoshida's technique is exploited to produce an arbitrary order implicit symplectic integrator and multi-map explicit integrator. This implicit integrator uses a characteristic function involving the force term alone. Also we point out the usefulness of the plain Ruth algorithm in computing Taylor series map using the techniques first introduced by Berz in his 'COSY-INFINITY' code.

Atlas - a data warehouse for integrative bioinformatics.

PubMed

Shah, Sohrab P; Huang, Yong; Xu, Tao; Yuen, Macaire M S; Ling, John; Ouellette, B F Francis

2005-02-21

We present a biological data warehouse called Atlas that locally stores and integrates biological sequences, molecular interactions, homology information, functional annotations of genes, and biological ontologies. The goal of the system is to provide data, as well as a software infrastructure for bioinformatics research and development. The Atlas system is based on relational data models that we developed for each of the source data types. Data stored within these relational models are managed through Structured Query Language (SQL) calls that are implemented in a set of Application Programming Interfaces (APIs). The APIs include three languages: C++, Java, and Perl. The methods in these API libraries are used to construct a set of loader applications, which parse and load the source datasets into the Atlas database, and a set of toolbox applications which facilitate data retrieval. Atlas stores and integrates local instances of GenBank, RefSeq, UniProt, Human Protein Reference Database (HPRD), Biomolecular Interaction Network Database (BIND), Database of Interacting Proteins (DIP), Molecular Interactions Database (MINT), IntAct, NCBI Taxonomy, Gene Ontology (GO), Online Mendelian Inheritance in Man (OMIM), LocusLink, Entrez Gene and HomoloGene. The retrieval APIs and toolbox applications are critical components that offer end-users flexible, easy, integrated access to this data. We present use cases that use Atlas to integrate these sources for genome annotation, inference of molecular interactions across species, and gene-disease associations. The Atlas biological data warehouse serves as data infrastructure for bioinformatics research and development. It forms the backbone of the research activities in our laboratory and facilitates the integration of disparate, heterogeneous biological sources of data enabling new scientific inferences. Atlas achieves integration of diverse data sets at two levels. First, Atlas stores data of similar types using common data models, enforcing the relationships between data types. Second, integration is achieved through a combination of APIs, ontology, and tools. The Atlas software is freely available under the GNU General Public License at: http://bioinformatics.ubc.ca/atlas/

Atlas – a data warehouse for integrative bioinformatics

PubMed Central

Shah, Sohrab P; Huang, Yong; Xu, Tao; Yuen, Macaire MS; Ling, John; Ouellette, BF Francis

2005-01-01

Background We present a biological data warehouse called Atlas that locally stores and integrates biological sequences, molecular interactions, homology information, functional annotations of genes, and biological ontologies. The goal of the system is to provide data, as well as a software infrastructure for bioinformatics research and development. Description The Atlas system is based on relational data models that we developed for each of the source data types. Data stored within these relational models are managed through Structured Query Language (SQL) calls that are implemented in a set of Application Programming Interfaces (APIs). The APIs include three languages: C++, Java, and Perl. The methods in these API libraries are used to construct a set of loader applications, which parse and load the source datasets into the Atlas database, and a set of toolbox applications which facilitate data retrieval. Atlas stores and integrates local instances of GenBank, RefSeq, UniProt, Human Protein Reference Database (HPRD), Biomolecular Interaction Network Database (BIND), Database of Interacting Proteins (DIP), Molecular Interactions Database (MINT), IntAct, NCBI Taxonomy, Gene Ontology (GO), Online Mendelian Inheritance in Man (OMIM), LocusLink, Entrez Gene and HomoloGene. The retrieval APIs and toolbox applications are critical components that offer end-users flexible, easy, integrated access to this data. We present use cases that use Atlas to integrate these sources for genome annotation, inference of molecular interactions across species, and gene-disease associations. Conclusion The Atlas biological data warehouse serves as data infrastructure for bioinformatics research and development. It forms the backbone of the research activities in our laboratory and facilitates the integration of disparate, heterogeneous biological sources of data enabling new scientific inferences. Atlas achieves integration of diverse data sets at two levels. First, Atlas stores data of similar types using common data models, enforcing the relationships between data types. Second, integration is achieved through a combination of APIs, ontology, and tools. The Atlas software is freely available under the GNU General Public License at: PMID:15723693

[Computerized monitoring for integrated cervical screening. Rationale, methods and indicators of participation].

PubMed

Bucchi, L; Pierri, C; Caprara, L; Cortecchia, S; De Lillo, M; Bondi, A

2003-02-01

This paper presents a computerised system for the monitoring of integrated cervical screening, i.e. the integration of spontaneous Pap smear practice into organised screening. The general characteristics of the system are described, including background and rationale (integrated cervical screening in European countries, impact of integration on monitoring, decentralised organization of screening and levels of monitoring), general methods (definitions, sections, software description, and setting of application), and indicators of participation (distribution by time interval since previous Pap smear, distribution by screening sector--organised screening centres vs public and private clinical settings--, distribution by time interval between the last two Pap smears, and movement of women between the two screening sectors). Also, the paper reports the results of the application of these indicators in the general database of the Pathology Department of Imola Health District in northern Italy.

Application-oriented integrated control center (AICC) for heterogeneous optical networks

NASA Astrophysics Data System (ADS)

Zhao, Yongli; Zhang, Jie; Cao, Xuping; Wang, Dajiang; Wu, Koubo; Cai, Yinxiang; Gu, Wanyi

2011-12-01

Various broad bandwidth services have being swallowing the bandwidth resource of optical networks, such as the data center application and cloud computation. There are still some challenges for future optical networks although the available bandwidth is increasing with the development of transmission technologies. The relationship between upper application layer and lower network resource layer is necessary to be researched further. In order to improve the efficiency of network resources and capability of service provisioning, heterogeneous optical networks resource can be abstracted as unified Application Programming Interfaces (APIs) which can be open to various upper applications through Application-oriented Integrated Control Center (AICC) proposed in the paper. A novel Openflow-based unified control architecture is proposed for the optimization of cross layer resources. Numeric results show good performance of AICC through simulation experiments.

Commercialisation of CMOS integrated circuit technology in multi-electrode arrays for neuroscience and cell-based biosensors.

PubMed

Graham, Anthony H D; Robbins, Jon; Bowen, Chris R; Taylor, John

2011-01-01

The adaptation of standard integrated circuit (IC) technology as a transducer in cell-based biosensors in drug discovery pharmacology, neural interface systems and electrophysiology requires electrodes that are electrochemically stable, biocompatible and affordable. Unfortunately, the ubiquitous Complementary Metal Oxide Semiconductor (CMOS) IC technology does not meet the first of these requirements. For devices intended only for research, modification of CMOS by post-processing using cleanroom facilities has been achieved. However, to enable adoption of CMOS as a basis for commercial biosensors, the economies of scale of CMOS fabrication must be maintained by using only low-cost post-processing techniques. This review highlights the methodologies employed in cell-based biosensor design where CMOS-based integrated circuits (ICs) form an integral part of the transducer system. Particular emphasis will be placed on the application of multi-electrode arrays for in vitro neuroscience applications. Identifying suitable IC packaging methods presents further significant challenges when considering specific applications. The various challenges and difficulties are reviewed and some potential solutions are presented.

Production roll out plan for HANDI 2000 business management system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, D.E.

The Hanford Data Integration 2000 (HANDI 2000) Project will result in an integrated and comprehensive set of functional applications containing core information necessary to support the Project Hanford Management Contract (PHMC). It is based on the Commercial-Off-The-Shelf (COTS) product solution with commercially proven business processes. The COTS product solution set, of Passport (PP) and PeopleSoft (PS) software, supports finance, supply, human resources, and payroll activities under the current PHMC direction. The PP software is an integrated application for Accounts Payable, Contract Management, Inventory Management, Purchasing and Material Safety Data Sheets (MSDS). The PS software is an integrated application for Projects,more » General Ledger, Human Resources Training, Payroll, and Base Benefits. This set of software constitutes the Business Management System (BMS) and MSDS, a subset of the HANDI 2000 suite of systems. The primary objective of the Production Roll Out Plan is to communicate the methods and schedules for implementation and roll out to end users of BMS.« less

Tri-Lab Co-Design Milestone: In-Depth Performance Portability Analysis of Improved Integrated Codes on Advanced Architecture.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoekstra, Robert J.; Hammond, Simon David; Richards, David

2017-09-01

This milestone is a tri-lab deliverable supporting ongoing Co-Design efforts impacting applications in the Integrated Codes (IC) program element Advanced Technology Development and Mitigation (ATDM) program element. In FY14, the trilabs looked at porting proxy application to technologies of interest for ATS procurements. In FY15, a milestone was completed evaluating proxy applications in multiple programming models and in FY16, a milestone was completed focusing on the migration of lessons learned back into production code development. This year, the co-design milestone focuses on extracting the knowledge gained and/or code revisions back into production applications.

ClusterControl: a web interface for distributing and monitoring bioinformatics applications on a Linux cluster.

PubMed

Stocker, Gernot; Rieder, Dietmar; Trajanoski, Zlatko

2004-03-22

ClusterControl is a web interface to simplify distributing and monitoring bioinformatics applications on Linux cluster systems. We have developed a modular concept that enables integration of command line oriented program into the application framework of ClusterControl. The systems facilitate integration of different applications accessed through one interface and executed on a distributed cluster system. The package is based on freely available technologies like Apache as web server, PHP as server-side scripting language and OpenPBS as queuing system and is available free of charge for academic and non-profit institutions. http://genome.tugraz.at/Software/ClusterControl

Introduction: Special issue on advances in topobathymetric mapping, models, and applications

USGS Publications Warehouse

Gesch, Dean B.; Brock, John C.; Parrish, Christopher E.; Rogers, Jeffrey N.; Wright, C. Wayne

2016-01-01

Detailed knowledge of near-shore topography and bathymetry is required for many geospatial data applications in the coastal environment. New data sources and processing methods are facilitating development of seamless, regional-scale topobathymetric digital elevation models. These elevation models integrate disparate multi-sensor, multi-temporal topographic and bathymetric datasets to provide a coherent base layer for coastal science applications such as wetlands mapping and monitoring, sea-level rise assessment, benthic habitat mapping, erosion monitoring, and storm impact assessment. The focus of this special issue is on recent advances in the source data, data processing and integration methods, and applications of topobathymetric datasets.

Developing improved silica materials and devices for integrated optics applications

NASA Astrophysics Data System (ADS)

Maker, Ashley Julia

Due to their favorable optical and material properties, silica-based materials and devices have found many important applications throughout science and engineering, especially in sensing, communications, lasers, and integrated optics. Often, silica's properties ultimately limit the performance of these applications. To address this limitation, this thesis investigates the development of improved silica materials and optical devices, including silica films, coatings, waveguides, resonators, lasers, and sensors. Using sol-gel chemistry and microfabrication procedures, custom silica materials and devices are developed to benefit many applications. In this thesis, it is first demonstrated how the low optical loss of silica enables fabrication of low loss integrated waveguides and toroidal resonators with ultra-high quality factors. Then, by adding various rare earth and metal dopants to sol-gel silica, hybrid silica materials and devices are made with custom properties such as high refractive index and lasing capabilities. Finally, several applications are demonstrated, including the use of high refractive index coatings to control the behavior of light, development of Raman and ultra-low threshold rare earth microlasers, and a heterodyned microlaser sensor with significantly improved sensing performance. Future applications and directions of this research are also discussed.

Time Triggered Protocol (TTP) for Integrated Modular Avionics

NASA Technical Reports Server (NTRS)

Motzet, Guenter; Gwaltney, David A.; Bauer, Guenther; Jakovljevic, Mirko; Gagea, Leonard

2006-01-01

Traditional avionics computing systems are federated, with each system provided on a number of dedicated hardware units. Federated applications are physically separated from one another and analysis of the systems is undertaken individually. Integrated Modular Avionics (IMA) takes these federated functions and integrates them on a common computing platform in a tightly deterministic distributed real-time network of computing modules in which the different applications can run. IMA supports different levels of criticality in the same computing resource and provides a platform for implementation of fault tolerance through hardware and application redundancy. Modular implementation has distinct benefits in design, testing and system maintainability. This paper covers the requirements for fault tolerant bus systems used to provide reliable communication between IMA computing modules. An overview of the Time Triggered Protocol (TTP) specification and implementation as a reliable solution for IMA systems is presented. Application examples in aircraft avionics and a development system for future space application are covered. The commercially available TTP controller can be also be implemented in an FPGA and the results from implementation studies are covered. Finally future direction for the application of TTP and related development activities are presented.

A collection of open source applications for mass spectrometry data mining.

PubMed

Gallardo, Óscar; Ovelleiro, David; Gay, Marina; Carrascal, Montserrat; Abian, Joaquin

2014-10-01

We present several bioinformatics applications for the identification and quantification of phosphoproteome components by MS. These applications include a front-end graphical user interface that combines several Thermo RAW formats to MASCOT™ Generic Format extractors (EasierMgf), two graphical user interfaces for search engines OMSSA and SEQUEST (OmssaGui and SequestGui), and three applications, one for the management of databases in FASTA format (FastaTools), another for the integration of search results from up to three search engines (Integrator), and another one for the visualization of mass spectra and their corresponding database search results (JsonVisor). These applications were developed to solve some of the common problems found in proteomic and phosphoproteomic data analysis and were integrated in the workflow for data processing and feeding on our LymPHOS database. Applications were designed modularly and can be used standalone. These tools are written in Perl and Python programming languages and are supported on Windows platforms. They are all released under an Open Source Software license and can be freely downloaded from our software repository hosted at GoogleCode. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Photonics technology development for optical fuzing.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, J.J.; Geib, Kent Martin; von der Lippe, C.M.

2005-07-01

This paper describes the photonic component development, which exploits pioneering work and unique expertise at Sandia National Laboratories, ARDEC and the Army Research Laboratory by combining key optoelectronic technologies to design and demonstrate components for this fuzing application. The technologies under investigation for the optical fuze design covered in this paper are vertical cavity surface emitting lasers (VECSELs), integrated resonant cavity photodetectors (RCPD), and diffractive micro-optics. The culmination of this work will be low cost, robust, fully integrated, g-hardened components designed suitable for proximity fuzing applications. The use of advanced photonic components will enable replacement of costly assemblies that employmore » discrete lasers, photodetectors, and bulk optics. The integrated devices will be mass produced and impart huge savings for a variety of Army applications.« less

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

PubMed Central

Yu, Junying; Hu, Kejin; Smuga-Otto, Kim; Tian, Shulan; Stewart, Ron; Slukvin, Igor I.; Thomson, James A.

2009-01-01

Reprogramming differentiated human cells to induced pluripotent stem (iPS) cells has applications in basic biology, drug development, and transplantation. Human iPS cell derivation previously required vectors that integrate into the genome, which can create mutations and limit the utility of the cells in both research and clinical applications. Here we describe the derivation of human iPS cells using non-integrating episomal vectors. After removal of the episome, iPS cells completely free of vector and transgene sequences are derived that are similar to human embryonic stem (ES) cells in proliferative and developmental potential. These results demonstrate that reprogramming human somatic cells does not require genomic integration or the continued presence of exogenous reprogramming factors, and removes one obstacle to the clinical application of human iPS cells. PMID:19325077

Micro-structural integrity of dental enamel subjected to two tooth whitening regimes.

PubMed

Tanaka, Reina; Shibata, Yo; Manabe, Atsufumi; Miyazaki, Takashi

2010-04-01

Colour modification of tooth enamel has proven successful, but it is unclear how various bleaching applications affect micro-structural integrity of the whitened enamel. To investigate the internal structural integrity of human intact tooth enamel with the application of two commonly used whitening regimes (in-office power bleaching with 35% hydrogen peroxide and home bleaching with 10% carbamide peroxide), evaluations were performed on teeth of identical colour classification. After the bleaching applications, the enamel mineral density was quantified and visualised with micro-computed tomography. The micro-structural differences between the whitened tooth enamel samples were distinctive, though the colour parameter changes within the samples were equivalent. Home bleaching achieved colour modification by demineralisation, whereas in-office bleaching depended on redistribution of the minerals after treatment and subsequent enhanced mineralisation.

Capacitive micromachined ultrasonic transducers for medical imaging and therapy.

PubMed

Khuri-Yakub, Butrus T; Oralkan, Omer

2011-05-01

Capacitive micromachined ultrasonic transducers (CMUTs) have been subject to extensive research for the last two decades. Although they were initially developed for air-coupled applications, today their main application space is medical imaging and therapy. This paper first presents a brief description of CMUTs, their basic structure, and operating principles. Our progression of developing several generations of fabrication processes is discussed with an emphasis on the advantages and disadvantages of each process. Monolithic and hybrid approaches for integrating CMUTs with supporting integrated circuits are surveyed. Several prototype transducer arrays with integrated frontend electronic circuits we developed and their use for 2-D and 3-D, anatomical and functional imaging, and ablative therapies are described. The presented results prove the CMUT as a MEMS technology for many medical diagnostic and therapeutic applications.

Automation of Shuttle Tile Inspection - Engineering methodology for Space Station

NASA Technical Reports Server (NTRS)

Wiskerchen, M. J.; Mollakarimi, C.

1987-01-01

The Space Systems Integration and Operations Research Applications (SIORA) Program was initiated in late 1986 as a cooperative applications research effort between Stanford University, NASA Kennedy Space Center, and Lockheed Space Operations Company. One of the major initial SIORA tasks was the application of automation and robotics technology to all aspects of the Shuttle tile processing and inspection system. This effort has adopted a systems engineering approach consisting of an integrated set of rapid prototyping testbeds in which a government/university/industry team of users, technologists, and engineers test and evaluate new concepts and technologies within the operational world of Shuttle. These integrated testbeds include speech recognition and synthesis, laser imaging inspection systems, distributed Ada programming environments, distributed relational database architectures, distributed computer network architectures, multimedia workbenches, and human factors considerations.

Analog integrated circuits design for processing physiological signals.

PubMed

Li, Yan; Poon, Carmen C Y; Zhang, Yuan-Ting

2010-01-01

Analog integrated circuits (ICs) designed for processing physiological signals are important building blocks of wearable and implantable medical devices used for health monitoring or restoring lost body functions. Due to the nature of physiological signals and the corresponding application scenarios, the ICs designed for these applications should have low power consumption, low cutoff frequency, and low input-referred noise. In this paper, techniques for designing the analog front-end circuits with these three characteristics will be reviewed, including subthreshold circuits, bulk-driven MOSFETs, floating gate MOSFETs, and log-domain circuits to reduce power consumption; methods for designing fully integrated low cutoff frequency circuits; as well as chopper stabilization (CHS) and other techniques that can be used to achieve a high signal-to-noise performance. Novel applications using these techniques will also be discussed.

The tapered slot antenna - A new integrated element for millimeter-wave applications

NASA Technical Reports Server (NTRS)

Yngvesson, K. Sigfrid; Kim, Young-Sik; Korzeniowski, T. L.; Kollberg, Erik L.; Johansson, Joakim F.

1989-01-01

Tapered slot antennas (TSAs) with a number of potential applications as single elements and focal-plane arrays are discussed. TSAs are fabricated with photolithographic techniques and integrated in either hybrid or MMIC circuits with receiver or transmitter components. They offer considerably narrower beams than other integrated antenna elements and have high aperture efficiency and packing density as array elements. Both the circuit and radiation properties of TSAs are reviewed. Topics covered include: antenna beamwidth, directivity, and gain of single-element TSAs; their beam shape and the effect of different taper shapes; and the input impedance and the effects of using thick dielectrics. These characteristics are also given for TSA arrays, as are the circuit properties of the array elements. Different array structures and their applications are also described.

Capacitive micromachined ultrasonic transducers for medical imaging and therapy

PubMed Central

Khuri-Yakub, Butrus T.; Oralkan, Ömer

2011-01-01

Capacitive micromachined ultrasonic transducers (CMUTs) have been subject to extensive research for the last two decades. Although they were initially developed for air-coupled applications, today their main application space is medical imaging and therapy. This paper first presents a brief description of CMUTs, their basic structure, and operating principles. Our progression of developing several generations of fabrication processes is discussed with an emphasis on the advantages and disadvantages of each process. Monolithic and hybrid approaches for integrating CMUTs with supporting integrated circuits are surveyed. Several prototype transducer arrays with integrated frontend electronic circuits we developed and their use for 2-D and 3-D, anatomical and functional imaging, and ablative therapies are described. The presented results prove the CMUT as a MEMS technology for many medical diagnostic and therapeutic applications. PMID:21860542

Applications of CCSDS recommendations to Integrated Ground Data Systems (IGDS)

NASA Technical Reports Server (NTRS)

Mizuta, Hiroshi; Martin, Daniel; Kato, Hatsuhiko; Ihara, Hirokazu

1993-01-01

This paper describes an application of the CCSDS Principle Network (CPH) service model to communications network elements of a postulated Integrated Ground Data System (IGDS). Functions are drawn principally from COSMICS (Cosmic Information and Control System), an integrated space control infrastructure, and the Earth Observing System Data and Information System (EOSDIS) Core System (ECS). From functional requirements, this paper derives a set of five communications network partitions which, taken together, support proposed space control infrastructures and data distribution systems. Our functional analysis indicates that the five network partitions derived in this paper should effectively interconnect the users, centers, processors, and other architectural elements of an IGDS. This paper illustrates a useful application of the CCSDS (Consultive Committee for Space Data Systems) Recommendations to ground data system development.

19 CFR 143.3 - Action on application.

Code of Federal Regulations, 2010 CFR

2010-04-01

... letter of intent; (2) The business integrity of the applicant; (3) The character and reputation of an... applicant by the Assistant Commissioner, Information and Technology, or his designee, written notice...

GIS Application System Design Applied to Information Monitoring

NASA Astrophysics Data System (ADS)

Qun, Zhou; Yujin, Yuan; Yuena, Kang

Natural environment information management system involves on-line instrument monitoring, data communications, database establishment, information management software development and so on. Its core lies in collecting effective and reliable environmental information, increasing utilization rate and sharing degree of environment information by advanced information technology, and maximizingly providing timely and scientific foundation for environmental monitoring and management. This thesis adopts C# plug-in application development and uses a set of complete embedded GIS component libraries and tools libraries provided by GIS Engine to finish the core of plug-in GIS application framework, namely, the design and implementation of framework host program and each functional plug-in, as well as the design and implementation of plug-in GIS application framework platform. This thesis adopts the advantages of development technique of dynamic plug-in loading configuration, quickly establishes GIS application by visualized component collaborative modeling and realizes GIS application integration. The developed platform is applicable to any application integration related to GIS application (ESRI platform) and can be as basis development platform of GIS application development.

Mission Applicability Assessment of Integrated Power Components and Systems

NASA Technical Reports Server (NTRS)

Raffaelle, R. P.; Hepp, A. F.; Landis, G. A.; Hoffman, D. J.

2002-01-01

The need for smaller lightweight autonomous power systems has recently increased with the increasing focus on micro- and nanosatellites. Small area high-efficiency thin film batteries and solar cells are an attractive choice for such applications. The NASA Glenn Research Center, Johns Hopkins Applied Physics Laboratory, Lithium Power Technologies, MicroSat Systems, and others, have been working on the development of autonomous monolithic packages combining these elements or what are called integrated power supplies (IPS). These supplies can be combined with individual satellite components and are capable of providing continuous power even under intermittent illumination associated with a spinning or Earth orbiting satellite. This paper discusses the space mission applicability, benefits, and current development efforts associated with integrated power supply components and systems. The characteristics and several mission concepts for an IPS that combines thin-film photovoltaic power generation with thin-film lithium ion energy storage are described. Based on this preliminary assessment, it is concluded that the most likely and beneficial application of an IPS will be for small "nanosatellites" or in specialized applications serving as a decentralized or as a distributed power source or uninterruptible power supply.

An integrated runtime and compile-time approach for parallelizing structured and block structured applications

NASA Technical Reports Server (NTRS)

Agrawal, Gagan; Sussman, Alan; Saltz, Joel

1993-01-01

Scientific and engineering applications often involve structured meshes. These meshes may be nested (for multigrid codes) and/or irregularly coupled (called multiblock or irregularly coupled regular mesh problems). A combined runtime and compile-time approach for parallelizing these applications on distributed memory parallel machines in an efficient and machine-independent fashion was described. A runtime library which can be used to port these applications on distributed memory machines was designed and implemented. The library is currently implemented on several different systems. To further ease the task of application programmers, methods were developed for integrating this runtime library with compilers for HPK-like parallel programming languages. How this runtime library was integrated with the Fortran 90D compiler being developed at Syracuse University is discussed. Experimental results to demonstrate the efficacy of our approach are presented. A multiblock Navier-Stokes solver template and a multigrid code were experimented with. Our experimental results show that our primitives have low runtime communication overheads. Further, the compiler parallelized codes perform within 20 percent of the code parallelized by manually inserting calls to the runtime library.

Integrated receiver for heterodyne detection dedicated to space applications

NASA Astrophysics Data System (ADS)

Fleury, Joel; Girard, Olivier; Royer, Michel; Bidaud, Michel

1998-10-01

This paper is devoted to the presentation of an Integrator Dewar Cooling Assembly dedicated to high frequency space applications. SAGEM SA has been a manufacturer of IR InSb and HgCdTe detectors for a long time. These detectors cover a large spectral range. The capability to use HgCdTe photovoltaic detectors for heterodyne applications at 10.6 micrometers has been demonstrated in the frame of ESA and CNES contracts. SAGEM SA has recently developed a new concept of heterodyne receiver, totally integrated, operating at variable temperatures down to 77K, using HgCdTe or InSb photovoltaic detectors. This receiver is an innovative product due to its small volume, its low weight and its low electrical consumption. The miniaturization of this product the latter to be used in space applications, specially for the earth observation missions. The performance of such a receiver with respect of the electrical bandwidth is presented in order to compare it with a receiver for terrestrial or airborne applications based on the use of a laboratory HF dewar.

Enriched Video Semantic Metadata: Authorization, Integration, and Presentation.

ERIC Educational Resources Information Center

Mu, Xiangming; Marchionini, Gary

2003-01-01

Presents an enriched video metadata framework including video authorization using the Video Annotation and Summarization Tool (VAST)-a video metadata authorization system that integrates both semantic and visual metadata-- metadata integration, and user level applications. Results demonstrated that the enriched metadata were seamlessly…

Assessing integrity of insect RNA

USDA-ARS?s Scientific Manuscript database

Assessing total RNA integrity is important for the success of downstream RNA applications. The 2100 Bioanalyzer system with the RNA Integrity Number (RIN) provides a quantitative measure of RNA degradation. Although RINs may not be ascertained for RNA from all organisms, namely those with unusual or...

Integrated Flight and Propulsion Controls for Advanced Aircraft Configurations

NASA Technical Reports Server (NTRS)

Merrill, Walter; Garg, Sanjay

1995-01-01

The research vision of the NASA Lewis Research Center in the area of integrated flight and propulsion controls technologies is described. In particular the Integrated Method for Propulsion and Airframe Controls developed at the Lewis Research Center is described including its application to an advanced aircraft configuration. Additionally, future research directions in integrated controls are described.

Integrated Flight and Propulsion Controls for Advanced Aircraft Configurations

NASA Technical Reports Server (NTRS)

Merrill, Walter; Garg, Sanjay

1996-01-01

The research vision of the NASA Lewis Research Center in the area of integrated flight and propulsion controls technologies is described. In particular, the integrated method for propulsion and airframe controls developed at the Lewis Research Center is described including its application to an advanced aircraft configuration. Additionally, future research directions in integrated controls are described.

Development and Testing of an Integrated Sandia Cooler Thermoelectric Device (SCTD).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Terry A.; Staats, Wayne Lawrence,; Leick, Michael Thomas

This report describes a FY14 effort to develop an integrated Sandia Cooler T hermoelectric D evice (SCTD) . The project included a review of feasible thermoelectric (TE) cooling applications, baseline performance testing of an existing TE device, analysis and design development of an integrated SCTD assembly, and performance measurement and validation of the integrated SCTD prototype.

Charge integration successive approximation analog-to-digital converter for focal plane applications using a single amplifier

NASA Technical Reports Server (NTRS)

Zhou, Zhimin (Inventor); Pain, Bedabrata (Inventor)

1999-01-01

An analog-to-digital converter for on-chip focal-plane image sensor applications. The analog-to-digital converter utilizes a single charge integrating amplifier in a charge balancing architecture to implement successive approximation analog-to-digital conversion. This design requires minimal chip area and has high speed and low power dissipation for operation in the 2-10 bit range. The invention is particularly well suited to CMOS on-chip applications requiring many analog-to-digital converters, such as column-parallel focal-plane architectures.

A Survey of Symplectic and Collocation Integration Methods for Orbit Propagation

NASA Technical Reports Server (NTRS)

Jones, Brandon A.; Anderson, Rodney L.

2012-01-01

Demands on numerical integration algorithms for astrodynamics applications continue to increase. Common methods, like explicit Runge-Kutta, meet the orbit propagation needs of most scenarios, but more specialized scenarios require new techniques to meet both computational efficiency and accuracy needs. This paper provides an extensive survey on the application of symplectic and collocation methods to astrodynamics. Both of these methods benefit from relatively recent theoretical developments, which improve their applicability to artificial satellite orbit propagation. This paper also details their implementation, with several tests demonstrating their advantages and disadvantages.

System-on-chip-centric unattended embedded sensors in homeland security and defense applications

NASA Astrophysics Data System (ADS)

Jannson, Tomasz; Forrester, Thomas; Degrood, Kevin; Shih, Min-Yi; Walter, Kevin; Lee, Kang; Gans, Eric; Esterkin, Vladimir

2009-05-01

System-on-chip (SoC) single-die electronic integrated circuit (IC) integration has recently been attracting a great deal of attention, due to its high modularity, universality, and relatively low fabrication cost. The SoC also has low power consumption and it is naturally suited to being a base for integration of embedded sensors. Such sensors can run unattended, and can be either commercial off-the-shelf (COTS) electronic, COTS microelectromechanical systems (MEMS), or optical-COTS or produced in house (i.e., at Physical Optics Corporation, POC). In the version with the simplest electronic packaging, they can be integrated with low-power wireless RF that can communicate with a central processing unit (CPU) integrated in-house and installed on the specific platform of interest. Such a platform can be a human body (for e-clothing), unmanned aerial vehicle (UAV), unmanned ground vehicle (UGV), or many others. In this paper we discuss SoC-centric embedded unattended sensors in Homeland Security and military applications, including specific application scenarios (or CONOPS). In one specific example, we analyze an embedded polarization optical sensor produced in house, including generalized Lambertian light-emitting diode (LED) sources and secondary nonimaging optics (NIO).

Silica Nanowires: Growth, Integration, and Sensing Applications

PubMed Central

Kaushik, Ajeet; Kumar, Rajesh; Huey, Eric; Bhansali, Shekhar; Nair, Narayana; Nanir, Madhavan

2014-01-01

This review (with 129 refs.) gives an overview on how the integration of silica nanowires (NWs) into micro-scale devices has resulted, in recent years, in simple yet robust nano-instrumentation with improved performance in targeted application areas such as sensing. This has been achieved by the use of appropriate techniques such as di-electrophoresis and direct vapor-liquid-growth phenomena, to restrict the growth of NWs to site-specific locations. This also has eliminated the need for post-growth processing and enables nanostructures to be placed on pre-patterned substrates. Various kinds of NWs have been investigated to determine how their physical and chemical properties can be tuned for integration into sensing structures. NWs integrated onto interdigitated micro-electrodes have been applied to the determination of gases and biomarkers. The technique of directly growing NWs eliminates the need for their physical transfer and thus preserves their structure and performance, and further reduces the costs of fabrication. The biocompatibility of NWs also has been studied with respect to possible biological applications. This review addresses the challenges in growth and integration of NWs to understand related mechanism on biological contact or gas exposure and sensing performance for personalized health and environmental monitoring. PMID:25382871

VLSI technology for smaller, cheaper, faster return link systems

NASA Technical Reports Server (NTRS)

Nanzetta, Kathy; Ghuman, Parminder; Bennett, Toby; Solomon, Jeff; Dowling, Jason; Welling, John

1994-01-01

Very Large Scale Integration (VLSI) Application-specific Integrated Circuit (ASIC) technology has enabled substantially smaller, cheaper, and more capable telemetry data systems. However, the rapid growth in available ASIC fabrication densities has far outpaced the application of this technology to telemetry systems. Available densities have grown by well over an order magnitude since NASA's Goddard Space Flight Center (GSFC) first began developing ASIC's for ground telemetry systems in 1985. To take advantage of these higher integration levels, a new generation of ASIC's for return link telemetry processing is under development. These new submicron devices are designed to further reduce the cost and size of NASA return link processing systems while improving performance. This paper describes these highly integrated processing components.

System-Level Integrated Circuit (SLIC) development for phased array antenna applications

NASA Technical Reports Server (NTRS)

Shalkhauser, K. A.; Raquet, C. A.

1991-01-01

A microwave/millimeter wave system-level integrated circuit (SLIC) being developed for use in phased array antenna applications is described. The program goal is to design, fabricate, test, and deliver an advanced integrated circuit that merges radio frequency (RF) monolithic microwave integrated circuit (MMIC) technologies with digital, photonic, and analog circuitry that provide control, support, and interface functions. As a whole, the SLIC will offer improvements in RF device performance, uniformity, and stability while enabling accurate, rapid, repeatable control of the RF signal. Furthermore, the SLIC program addresses issues relating to insertion of solid state devices into antenna systems, such as the reduction in number of bias, control, and signal lines. Program goals, approach, and status are discussed.

Examination of Frameworks for Safe Integration of Intelligent Small UAS into the NAS

NASA Technical Reports Server (NTRS)

Logan, Michael J.

2012-01-01

This paper discusses a proposed framework for the safe integration of small unmanned aerial systems (sUAS) into the National Airspace System (NAS). The paper briefly examines the potential uses of sUAS to build an understanding of the location and frequency of potential future flight operations based on the future applications of the sUAS systems. The paper then examines the types of systems that would be required to meet the application-level demand to determine "classes" of platforms and operations. A framework for categorization of the "intelligence" level of the UAS is postulated for purposes of NAS integration. Finally, constraints on the intelligent systems are postulated to ensure their ease of integration into the NAS.

Chip-integrated nearly perfect absorber at telecom wavelengths by graphene coupled with nanobeam cavity.

PubMed

Xu, W; Zhu, Z H; Liu, K; Zhang, J F; Yuan, X D; Lu, Q S; Qin, S Q

2015-07-15

We exploit the concept of critical coupling to graphene based chip-integrated applications and numerically demonstrate that a chip-integrated nearly perfect graphene absorber at wavelengths around 1.55 μm can be obtained by graphene nearly critical coupling with a nanobeam cavity. The key points are reducing the radiation loss and transmission possibly, together with controlling the coupling rate of the cavity to the input waveguide to be equal to the absorption rate of the cavity caused by graphene. Simulation results show that the absorption of monolayer graphene with a total length of only a few microns is raised up to 97%. Our study may have potential applications in chip-integrated photodetectors.

System-level integrated circuit (SLIC) development for phased array antenna applications

NASA Technical Reports Server (NTRS)

Shalkhauser, K. A.; Raquet, C. A.

1991-01-01

A microwave/millimeter wave system-level integrated circuit (SLIC) being developed for use in phased array antenna applications is described. The program goal is to design, fabricate, test, and deliver an advanced integrated circuit that merges radio frequency (RF) monolithic microwave integrated circuit (MMIC) technologies with digital, photonic, and analog circuitry that provide control, support, and interface functions. As a whole, the SLIC will offer improvements in RF device performance, uniformity, and stability while enabling accurate, rapid, repeatable control of the RF signal. Furthermore, the SLIC program addresses issues relating to insertion of solid state devices into antenna systems, such as the reduction in number of bias, control, and signal lines. Program goals, approach, and status are discussed.

Integration Science and Technology of Advanced Ceramics for Energy and Environmental Applications

NASA Technical Reports Server (NTRS)

Singh, M.

2012-01-01

The discovery of new and innovative materials has been known to culminate in major turning points in human history. The transformative impact and functional manifestation of new materials have been demonstrated in every historical era by their integration into new products, systems, assemblies, and devices. In modern times, the integration of new materials into usable products has a special relevance for the technological development and economic competitiveness of industrial societies. Advanced ceramic technologies dramatically impact the energy and environmental landscape due to potential wide scale applications in all aspects of energy production, storage, distribution, conservation, and efficiency. Examples include gas turbine propulsion systems, fuel cells, thermoelectrics, photovoltaics, distribution and transmission systems based on superconductors, nuclear power generation, and waste disposal. Robust ceramic integration technologies enable hierarchical design and manufacturing of intricate ceramic components starting with geometrically simpler units that are subsequently joined to themselves and/or to metals to create components with progressively higher levels of complexity and functionality. However, for the development of robust and reliable integrated systems with optimum performance under different operating conditions, the detailed understanding of various thermochemical and thermomechanical factors is critical. Different approaches are required for the integration of ceramic-metal and ceramic-ceramic systems across length scales (macro to nano). In this presentation, a few examples of integration of ceramic to metals and ceramic to ceramic systems will be presented. Various challenges and opportunities in design, fabrication, and testing of integrated similar (ceramic-ceramic) and dissimilar (ceramic-metal) material systems will be discussed. Potential opportunities and need for the development of innovative design philosophies, approaches, and integrated system testing under simulated application conditions will also be presented.

Visual-vestibular cue integration for heading perception: applications of optimal cue integration theory.

PubMed

Fetsch, Christopher R; Deangelis, Gregory C; Angelaki, Dora E

2010-05-01

The perception of self-motion is crucial for navigation, spatial orientation and motor control. In particular, estimation of one's direction of translation, or heading, relies heavily on multisensory integration in most natural situations. Visual and nonvisual (e.g., vestibular) information can be used to judge heading, but each modality alone is often insufficient for accurate performance. It is not surprising, then, that visual and vestibular signals converge frequently in the nervous system, and that these signals interact in powerful ways at the level of behavior and perception. Early behavioral studies of visual-vestibular interactions consisted mainly of descriptive accounts of perceptual illusions and qualitative estimation tasks, often with conflicting results. In contrast, cue integration research in other modalities has benefited from the application of rigorous psychophysical techniques, guided by normative models that rest on the foundation of ideal-observer analysis and Bayesian decision theory. Here we review recent experiments that have attempted to harness these so-called optimal cue integration models for the study of self-motion perception. Some of these studies used nonhuman primate subjects, enabling direct comparisons between behavioral performance and simultaneously recorded neuronal activity. The results indicate that humans and monkeys can integrate visual and vestibular heading cues in a manner consistent with optimal integration theory, and that single neurons in the dorsal medial superior temporal area show striking correlates of the behavioral effects. This line of research and other applications of normative cue combination models should continue to shed light on mechanisms of self-motion perception and the neuronal basis of multisensory integration.

Nano-array integrated monolithic devices: toward rational materials design and multi-functional performance by scalable nanostructures assembly

DOE PAGES

Wang, Sibo; Ren, Zheng; Guo, Yanbing; ...

2016-03-21

We report the scalable three-dimensional (3-D) integration of functional nanostructures into applicable platforms represents a promising technology to meet the ever-increasing demands of fabricating high performance devices featuring cost-effectiveness, structural sophistication and multi-functional enabling. Such an integration process generally involves a diverse array of nanostructural entities (nano-entities) consisting of dissimilar nanoscale building blocks such as nanoparticles, nanowires, and nanofilms made of metals, ceramics, or polymers. Various synthetic strategies and integration methods have enabled the successful assembly of both structurally and functionally tailored nano-arrays into a unique class of monolithic devices. The performance of nano-array based monolithic devices is dictated bymore » a few important factors such as materials substrate selection, nanostructure composition and nano-architecture geometry. Therefore, the rational material selection and nano-entity manipulation during the nano-array integration process, aiming to exploit the advantageous characteristics of nanostructures and their ensembles, are critical steps towards bridging the design of nanostructure integrated monolithic devices with various practical applications. In this article, we highlight the latest research progress of the two-dimensional (2-D) and 3-D metal and metal oxide based nanostructural integrations into prototype devices applicable with ultrahigh efficiency, good robustness and improved functionality. Lastly, selective examples of nano-array integration, scalable nanomanufacturing and representative monolithic devices such as catalytic converters, sensors and batteries will be utilized as the connecting dots to display a roadmap from hierarchical nanostructural assembly to practical nanotechnology implications ranging from energy, environmental, to chemical and biotechnology areas.« less

Nano-array integrated monolithic devices: toward rational materials design and multi-functional performance by scalable nanostructures assembly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Sibo; Ren, Zheng; Guo, Yanbing

We report the scalable three-dimensional (3-D) integration of functional nanostructures into applicable platforms represents a promising technology to meet the ever-increasing demands of fabricating high performance devices featuring cost-effectiveness, structural sophistication and multi-functional enabling. Such an integration process generally involves a diverse array of nanostructural entities (nano-entities) consisting of dissimilar nanoscale building blocks such as nanoparticles, nanowires, and nanofilms made of metals, ceramics, or polymers. Various synthetic strategies and integration methods have enabled the successful assembly of both structurally and functionally tailored nano-arrays into a unique class of monolithic devices. The performance of nano-array based monolithic devices is dictated bymore » a few important factors such as materials substrate selection, nanostructure composition and nano-architecture geometry. Therefore, the rational material selection and nano-entity manipulation during the nano-array integration process, aiming to exploit the advantageous characteristics of nanostructures and their ensembles, are critical steps towards bridging the design of nanostructure integrated monolithic devices with various practical applications. In this article, we highlight the latest research progress of the two-dimensional (2-D) and 3-D metal and metal oxide based nanostructural integrations into prototype devices applicable with ultrahigh efficiency, good robustness and improved functionality. Lastly, selective examples of nano-array integration, scalable nanomanufacturing and representative monolithic devices such as catalytic converters, sensors and batteries will be utilized as the connecting dots to display a roadmap from hierarchical nanostructural assembly to practical nanotechnology implications ranging from energy, environmental, to chemical and biotechnology areas.« less

A design for integration.

PubMed

Fenna, D

1977-09-01

For nearly two decades, the development of computerized information systems has struggled for acceptable compromises between the unattainable "total system" and the unacceptable separate applications. Integration of related applications is essential if the computer is to be exploited fully, yet relative simplicity is necessary for systems to be implemented in a reasonable time-scale. This paper discusses a system being progressively developed from minimal beginnings but which, from the outset, had a highly flexible and fully integrated system basis. The system is for batch processing, but can accommodate on-line data input; it is similar in its approach to many transaction-processing real-time systems.

Development, Qualification and Integration of the Optical Fiber Array Assemblies for the Lunar Reconnaissance Orbiter

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; Switzer, Robert; Chuska, Richard; LaRocca, Frank; Thomas, William Joe; Macmurphy, Shawn

2008-01-01

The NASA Goddard Fiber Optics Team in the Electrical Engineering Division of the Applied Engineering and Technology Directorate, designed, developed and integrated the space flight optical fiber array hardware for the Lunar Reconnaissance Orbiter (LRO). The two new assemblies that were designed and manufacturing at GSFC for the LRO exist in configurations that are unique in the world for the application of ranging and LIDAR. Described here is an account of the journey and the lessons learned from design to integration for the Lunar Orbiter Laser Altimeter and the Laser Ranging Application on the LRO.

Integrated infrared detector arrays for low-background applications

NASA Technical Reports Server (NTRS)

Mccreight, C. R.; Goebel, J. H.

1982-01-01

Advanced infrared detector and detector array technology is being developed and characterized for future NASA space astronomy applications. Si:Bi charge-injection-device arrays have been obtained, and low-background sensitivities comparable to that of good discrete detectors have been measured. Intrinsic arrays are being assessed, and laboratory and telescope data have been collected on a monolithic InSb CCD array. For wavelengths longer than 30 microns, improved Ge:Ga detectors have been produced, and steps have been taken to prove the feasibility of an integrated extrinsic germanium array. Other integrated arrays and cryogenic components are also under investigation.

Recruitment recommendation system based on fuzzy measure and indeterminate integral

NASA Astrophysics Data System (ADS)

Yin, Xin; Song, Jinjie

2017-08-01

In this study, we propose a comprehensive evaluation approach based on indeterminate integral. By introducing the related concepts of indeterminate integral and their formulas into the recruitment recommendation system, we can calculate the suitability of each job for different applicants with the defined importance for each criterion listed in the job advertisements, the association between different criteria and subjective assessment as the prerequisite. Thus we can make recommendations to the applicants based on the score of the suitability of each job from high to low. In the end, we will exemplify the usefulness and practicality of this system with samples.

Engineering Elegant Systems: Postulates, Principles, and Hypotheses of Systems Engineering

NASA Technical Reports Server (NTRS)

Watson, Michael D.

2018-01-01

Definition: System Engineering is the engineering discipline which integrates the system functions, system environment, and the engineering disciplines necessary to produce and/or operate an elegant system; Elegant System - A system that is robust in application, fully meeting specified and adumbrated intent, is well structured, and is graceful in operation. Primary Focus: System Design and Integration: Identify system couplings and interactions; Identify system uncertainties and sensitivities; Identify emergent properties; Manage the effectiveness of the system. Engineering Discipline Integration: Manage flow of information for system development and/or operations; Maintain system activities within budget and schedule. Supporting Activities: Process application and execution.

Applications of δ-function perturbation to the pricing of derivative securities

NASA Astrophysics Data System (ADS)

Decamps, Marc; De Schepper, Ann; Goovaerts, Marc

2004-11-01

In the recent econophysics literature, the use of functional integrals is widespread for the calculation of option prices. In this paper, we extend this approach in several directions by means of δ-function perturbations. First, we show that results about infinitely repulsive δ-function are applicable to the pricing of barrier options. We also introduce functional integrals over skew paths that give rise to a new European option formula when combined with δ-function potential. We propose accurate closed-form approximations based on the theory of comonotonic risks in case the functional integrals are not analytically computable.

Quality health care in the European Union thanks to competition law.

PubMed

Fornaciari, Diego

2010-01-01

There are many biases concerning the application of competition law in health care. Quality concerns can however be integrated into competition law analysis. The aim of this paper is to identify the links between the application of competition law in the European Union and the right to quality health care and to point out the problems that arise when integrating quality concerns in competition law analysis. Guidelines must be issued and competition authorities must work together with institutions that have expertise in the field of health care quality measurement in order to integrate these dimensions in competition practice.

Boolean integral calculus

NASA Technical Reports Server (NTRS)

Tucker, Jerry H.; Tapia, Moiez A.; Bennett, A. Wayne

1988-01-01

The concept of Boolean integration is developed, and different Boolean integral operators are introduced. Given the changes in a desired function in terms of the changes in its arguments, the ways of 'integrating' (i.e. realizing) such a function, if it exists, are presented. The necessary and sufficient conditions for integrating, in different senses, the expression specifying the changes are obtained. Boolean calculus has applications in the design of logic circuits and in fault analysis.

Optoelectronic devices toward monolithic integration

NASA Astrophysics Data System (ADS)

Ghergia, V.

1992-12-01

Starting from the present state of tl art of discrete devices up to the on going realization of monolithic semicorxtuctor integrated prototypes an overview ofoptoelectronic devices for telecom applications is given inchiding a short classification of the different kind of integrated devices. On the future perspective of IBCN distribution network some economica of hybrid and monolithic forms of integration are attempted. lnaflyashoitpresentationoftheactivitiesperformedintbefieldofmonolithic integration by EEC ESPR1T and RACE projects is reported. 1.

Exploring Gender Differences in Predicting Physical Activity among Elementary Aged Children: An Application of the Integrated Behavioral Model

ERIC Educational Resources Information Center

Branscum, Paul; Bhochhibhoya, Amir

2016-01-01

Background: The integrated behavioral model (IBM) is a new and emerging theory in the field of health promotion and health education, and more applications are needed to test the usefulness of the model for research and practice. Purpose: The purpose of this study was to operationalize the IBM as it relates to physical activity (PA) among children…

Integrated detector array technology for infrared astronomy

NASA Technical Reports Server (NTRS)

Mccreight, c. R.; Goebel, J. H.; Mckelvey, M. E.; Stafford, P. S.; Lee, J. H.

1984-01-01

The status of laboratory and telescope tests of integrated infrared detector array technology for astronomical applications is described. The devices tested represent a number of extrinsic and intrinsic detector materials and various multiplexer designs. Infrared arrays have now been used in successful astronomical applications. These have shown that device sensitivities can be comparable to those of discrete detector systems and excellent astronomical imagery can be produced.