Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields

NASA Astrophysics Data System (ADS)

Reinscheid, Uwe M.

2009-08-01

The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.

Method of using triaxial magnetic fields for making particle structures

DOEpatents

Martin, James E.; Anderson, Robert A.; Williamson, Rodney L.

2005-01-18

A method of producing three-dimensional particle structures with enhanced magnetic susceptibility in three dimensions by applying a triaxial energetic field to a magnetic particle suspension and subsequently stabilizing said particle structure. Combinations of direct current and alternating current fields in three dimensions produce particle gel structures, honeycomb structures, and foam-like structures.

Moral injury: A new challenge for complementary and alternative medicine.

PubMed

Kopacz, Marek S; Connery, April L; Bishop, Todd M; Bryan, Craig J; Drescher, Kent D; Currier, Joseph M; Pigeon, Wilfred R

2016-02-01

Moral injury represents an emerging clinical construct recognized as a source of morbidity in current and former military personnel. Finding effective ways to support those affected by moral injury remains a challenge for both biomedical and complementary and alternative medicine. This paper introduces the concept of moral injury and suggests two complementary and alternative medicine, pastoral care and mindfulness, which may prove useful in supporting military personnel thought to be dealing with moral injury. Research strategies for developing an evidence-base for applying these, and other, complementary and alternative medicine modalities to moral injury are discussed. Published by Elsevier Ltd.

Alternating current circuit theory and pulsed NMR (Nuclear Magnetic Resonance)

NASA Astrophysics Data System (ADS)

Gerstein, B. C.

1987-06-01

Pulsed NMR, by definition, deals with time varying excitations. These excitations, supplied by resonant circuits which provide a pulse of radiofrequency (frequencies in the megahertz region) power to a resonant circuit containing, among other things, a coil of wire, or inductor, in which a sample under investigation is placed for purposes of the nuclear magnetic resonance experiment. There are therefore two features of the pulse NMR experiment. First is the fact that we have available a source of continuous wave (CW) alternating current at some angular frequency, omega, measured in radians per second. This source is generally supplied by an ultrastable device called a frequency synthesizer. The second feature of the pulsed NMR experiment is that the sample is not continuously irradiated, but a pulse of radiofrequency oscillation is applied to the sample. This report discusses alternating current theory, resonant circuits and the equipment used in this experiment.

Enhancement of multitasking performance and neural oscillations by transcranial alternating current stimulation

PubMed Central

Zanto, Theodore P.; van Schouwenburg, Martine R.; Gazzaley, Adam

2017-01-01

Multitasking is associated with the generation of stimulus-locked theta (4–7 Hz) oscillations arising from prefrontal cortex (PFC). Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that influences endogenous brain oscillations. Here, we investigate whether applying alternating current stimulation within the theta frequency band would affect multitasking performance, and explore tACS effects on neurophysiological measures. Brief runs of bilateral PFC theta-tACS were applied while participants were engaged in a multitasking paradigm accompanied by electroencephalography (EEG) data collection. Unlike an active control group, a tACS stimulation group showed enhancement of multitasking performance after a 90-minute session (F1,35 = 6.63, p = 0.01, ηp2 = 0.16; effect size = 0.96), coupled with significant modulation of posterior beta (13–30 Hz) activities (F1,32 = 7.66, p = 0.009, ηp2 = 0.19; effect size = 0.96). Across participant regression analyses indicated that those participants with greater increases in frontal theta, alpha and beta oscillations exhibited greater multitasking performance improvements. These results indicate frontal theta-tACS generates benefits on multitasking performance accompanied by widespread neuronal oscillatory changes, and suggests that future tACS studies with extended treatments are worth exploring as promising tools for cognitive enhancement. PMID:28562642

Enhancement of multitasking performance and neural oscillations by transcranial alternating current stimulation.

PubMed

Hsu, Wan-Yu; Zanto, Theodore P; van Schouwenburg, Martine R; Gazzaley, Adam

2017-01-01

Multitasking is associated with the generation of stimulus-locked theta (4-7 Hz) oscillations arising from prefrontal cortex (PFC). Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that influences endogenous brain oscillations. Here, we investigate whether applying alternating current stimulation within the theta frequency band would affect multitasking performance, and explore tACS effects on neurophysiological measures. Brief runs of bilateral PFC theta-tACS were applied while participants were engaged in a multitasking paradigm accompanied by electroencephalography (EEG) data collection. Unlike an active control group, a tACS stimulation group showed enhancement of multitasking performance after a 90-minute session (F1,35 = 6.63, p = 0.01, ηp2 = 0.16; effect size = 0.96), coupled with significant modulation of posterior beta (13-30 Hz) activities (F1,32 = 7.66, p = 0.009, ηp2 = 0.19; effect size = 0.96). Across participant regression analyses indicated that those participants with greater increases in frontal theta, alpha and beta oscillations exhibited greater multitasking performance improvements. These results indicate frontal theta-tACS generates benefits on multitasking performance accompanied by widespread neuronal oscillatory changes, and suggests that future tACS studies with extended treatments are worth exploring as promising tools for cognitive enhancement.

Characterizing AISI 1045 steel surface duplex-treated by alternating current field enhanced pack aluminizing and nitriding

NASA Astrophysics Data System (ADS)

Xie, Fei; Zhang, Ge; Pan, Jianwei

2018-02-01

Thin cases and long treating time are shortcomings of conventional duplex treatment of aluminizing followed by nitriding (DTAN). Alternating current field (ACF) enhanced DTAN was carried out on AISI 1045 steel by applying an ACF to treated samples and treating agents with a pair of electrodes for overcoming those shortcomings. By investigating cases' structures, phases, composition and hardness distributions of differently treated samples, preliminary studies were made on characterizations of the ACF enhanced duplex treatment to AISI 1045 steel. The results show that, with the help of the ACF, the surface Al-rich phase Al5Fe2 formed in conventional pack aluminizing can be easily avoided and the aluminizing process is dramatically promoted. The aluminizing case can be nitrided either with conventional pack nitriding or ACF enhanced pack nitriding. By applying ACF to pack nitriding, the diffusion of nitrogen into the aluminizing case is promoted. AlN, Fe2∼3N and solid solution of N in iron are efficiently formed as a result of reactions of N with the aluminizing case. A duplex treated case with an effective thickness of more than 170 μm can be obtained by the alternating current field enhanced 4 h pack aluminizing plus 4 h pack nitriding.

Frequency-dependent failure mechanisms of nanocrystalline gold interconnect lines under general alternating current

NASA Astrophysics Data System (ADS)

Luo, X. M.; Zhang, B.; Zhang, G. P.

2014-09-01

Thermal fatigue failure of metallization interconnect lines subjected to alternating currents (AC) is becoming a severe threat to the long-term reliability of micro/nanodevices with increasing electrical current density/power. Here, thermal fatigue failure behaviors and damage mechanisms of nanocrystalline Au interconnect lines on the silicon glass substrate have been investigated by applying general alternating currents (the pure alternating current coupled with a direct current (DC) component) with different frequencies ranging from 0.05 Hz to 5 kHz. We observed both thermal fatigue damages caused by Joule heating-induced cyclic strain/stress and electromigration (EM) damages caused by the DC component. Besides, the damage formation showed a strong electrically-thermally-mechanically coupled effect and frequency dependence. At lower frequencies, thermal fatigue damages were dominant and the main damage forms were grain coarsening with grain boundary (GB) cracking/voiding and grain thinning. At higher frequencies, EM damages took over and the main damage forms were GB cracking/voiding of smaller grains and hillocks. Furthermore, the healing effect of the reversing current was considered to elucidate damage mechanisms of the nanocrystalline Au lines generated by the general AC. Lastly, a modified model was proposed to predict the lifetime of the nanocrystalline metal interconnect lines, i.e., that was a competing drift velocity-based approach based on the threshold time required for reverse diffusion/healing to occur.

Effect of Modulated Alternating and Direct Current Iontophoresis on Transdermal Delivery of Lidocaine Hydrochloride

PubMed Central

Banga, Ajay K.

2014-01-01

The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/v solution of lidocaine hydrochloride. Tape stripping was done to quantify the amount of drug permeated into stratum corneum and skin extraction studies were performed to determine the amount of drug in stripped skin. Receptor was sampled and analyzed over predefined time periods. The amount of lidocaine delivered across porcine skin after modulated direct current iontophoresis for 2 h was 1069.87 ± 120.03 μg/sq·cm compared to 744.81 ± 125.41 μg/sq·cm after modulated alternating current iontophoresis for 2 h. Modulated direct current iontophoresis also enhanced lidocaine delivery by twelvefold compared to passive delivery as 91.27 ± 18.71 μg/sq·cm of lidocaine was delivered after passive delivery. Modulated iontophoresis enhanced the delivery of lidocaine hydrochloride across porcine skin compared to the passive delivery. Modulated alternating current iontophoresis for duration of 2 h at frequency of 1 kHz was found to be comparable to the continuous direct current iontophoresis for 1 h. PMID:24959580

Effect of modulated alternating and direct current iontophoresis on transdermal delivery of lidocaine hydrochloride.

PubMed

Bhatia, Gaurav; Banga, Ajay K

2014-01-01

The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/v solution of lidocaine hydrochloride. Tape stripping was done to quantify the amount of drug permeated into stratum corneum and skin extraction studies were performed to determine the amount of drug in stripped skin. Receptor was sampled and analyzed over predefined time periods. The amount of lidocaine delivered across porcine skin after modulated direct current iontophoresis for 2 h was 1069.87 ± 120.03 μ g/sq · cm compared to 744.81 ± 125.41 μ g/sq · cm after modulated alternating current iontophoresis for 2 h. Modulated direct current iontophoresis also enhanced lidocaine delivery by twelvefold compared to passive delivery as 91.27 ± 18.71 μ g/sq · cm of lidocaine was delivered after passive delivery. Modulated iontophoresis enhanced the delivery of lidocaine hydrochloride across porcine skin compared to the passive delivery. Modulated alternating current iontophoresis for duration of 2 h at frequency of 1 kHz was found to be comparable to the continuous direct current iontophoresis for 1 h.

Research and development of an electrochemical biocide reactor

NASA Technical Reports Server (NTRS)

See, G. G.; Bodo, C. A.; Glennon, J. P.

1975-01-01

An alternate disinfecting process to chemical agents, heat, or radiation in an aqueous media has been studied. The process is called an electrochemical biocide and employs cyclic, low-level voltages at chemically inert electrodes to pass alternating current through water and, in the process, to destroy microorganisms. The paper describes experimental hardware, methodology, and results with a tracer microorganism (Escherichia coli). The results presented show the effects on microorganism kill of operating parameters, including current density (15 to 55 mA/sq cm (14 to 51 ASF)), waveform of applied electrical signal (square, triangular, sine), frequency of applied electrical signal (0.5 to 1.5 Hz), process water flow rate (100 to 600 cc/min (1.6 to 9.5 gph)), and reactor resident time (0 to 4 min). Comparisons are made between the disinfecting property of the electrochemical biocide and chlorine, bromine, and iodine.

Alternating method applied to edge and surface crack problems

NASA Technical Reports Server (NTRS)

Hartranft, R. J.; Sih, G. C.

1972-01-01

The Schwarz-Neumann alternating method is employed to obtain stress intensity solutions to two crack problems of practical importance: a semi-infinite elastic plate containing an edge crack which is subjected to concentrated normal and tangential forces, and an elastic half space containing a semicircular surface crack which is subjected to uniform opening pressure. The solution to the semicircular surface crack is seen to be a significant improvement over existing approximate solutions. Application of the alternating method to other crack problems of current interest is briefly discussed.

Alternatives to the use of animals in safety testing as required by the EU-Cosmetics Directive 2009.

PubMed

Vogel, Richard

2009-01-01

Ingredients of cosmetic products are no longer allowed to be tested by animal experimentation (EU-Cosmetics Directive 76/768 EEC). For several toxicological endpoints this testing ban applies since March 11, 2009, while repeated dose toxicity tests and the test on skin sensitisation will follow on March 11, 2013. All currently available alternatives meeting the requirements of the first deadline are compiled in the following.

School-Based Initial Vocational Education in the Republic of Ireland: The Parity of Esteem and Fitness for Purpose of the Leaving Certificate Applied

ERIC Educational Resources Information Center

Gleeson, Jim; O'Flaherty, Joanne

2013-01-01

The Irish Leaving Certificate Applied (LCA) is a school-based, pre-vocational alternative to the "high stakes" established Leaving Certificate. Its origins lie in European Union funded "school to work" initiatives and it is currently taken to completion by some 5% of Irish senior cycle students. Since it was designed 20 years…

Evaluation, development, and characterization of superconducting materials for space applications

NASA Technical Reports Server (NTRS)

Thorpe, Arthur N.

1990-01-01

The anisotropic electromagnetic features of a grain-aligned YBa2Cu3O(x) bulk sample derived from a process of long-time partial melt growth were investigated by the measurements of direct current magnetization (at 77 K) and alternating current susceptibility as a function of temperature, with the fields applied parallel and perpendicular to the c axis, respectively. The extended Bean model was further studied and applied to explain the experimental results. Upon comparison of the grain-aligned sample with pure single crystal materials, it is concluded that because of the existence of more effective pinning sites in the grain-aligned sample, not only its critical current density perpendicular to the c axis is improved, but the one parallel to the c axis is improved even more significantly. The anisotropy in the critical current densities in the grain-aligned sample at 77 K is at least one to two orders of magnitude smaller than in the pure single crystal. The measurement of anisotropy of alternating current susceptibility as a function of temperature, especially its imaginary part, shows that there are still some residues of interlayer weak links in the grain-aligned samples, but they are quite different from and far less serious than the weak links in the sintered sample.

Nitrate removal from pharmaceutical wastewater using microbial electrochemical system supplied through low frequency-low voltage alternating electric current.

PubMed

Hoseinzadeh, Edris; Rezaee, Abbas; Farzadkia, Mahdi

2018-04-01

In this study, a microbial electrochemical system (MES) was designed to evaluate the effects of a low frequency-low voltage alternating electrical current on denitrification efficacy in the presence of ibuprofen as a low biodegradable organic carbon source. Cylindrical carbon cloth and stainless steel mesh electrodes containing a consortium of heterotrophic and autotrophic bacteria were mounted in the wall of the designed laboratory-scale bioreactor. The effects of inlet nitrate concentration (50-800mgL -1 ), retention time (2.5-24h), waveform magnitude (0.1-9.6V p-p ), adjustable direct current voltage added to offset voltage (0.1-4.9V), alternating current frequency (10-60Hz), and waveforms (sinusoidal, square, and ramp) were studied in this work. The results showed that the proposed system removes 800mgL -1 nitrate up to 95% during 6.5h. Optimum conditions were obtained in the 8V p-p using a frequency of 10Hz of a sinusoidal waveform. The morphology studies confirmed bacterial morphology change when applying the alternating current. Dehydrogenase activity of biofilms formed on surface of stainless steel electrodes increased to 15.24μgTFmg biomass cm -2 d. The maximum bacterial activity was obtained at a voltage of 8V p-p . The experimental results revealed that the MES using a low frequency-low voltage alternating electrical current is a promising technique for nitrate removal from pharmaceutical wastewaters in the presence of low biodegradability of carbon sources such as ibuprofen. Copyright © 2017 Elsevier B.V. All rights reserved.

Use of alternating and pulsed direct current electrified fields for zebra mussel control

USGS Publications Warehouse

Luoma, James A.; Dean, Jan C.; Severson, Todd J.; Wise, Jeremy K.; Barbour, Matthew

2017-01-01

Alternatives to chemicals for controlling dreissenid mussels are desirable for environmental compatibility, but few alternatives exist. Previous studies have evaluated the use of electrified fields for stunning and/or killing planktonic life stages of dreissenid mussels, however, the available literature on the use of electrified fields to control adult dreissenid mussels is limited. We evaluated the effects of sinusoidal alternating current (AC) and 20% duty cycle square-wave pulsed direct current (PDC) exposure on the survival of adult zebra mussels at water temperatures of 10, 15, and 22 °C. Peak voltage gradients of ~ 17 and 30 Vp/cm in the AC and PDC exposures, respectively, were continuously applied for 24, 48, or 72 h. Peak power densities ranged from 77,999 to 107,199 µW/cm3 in the AC exposures and 245,320 to 313,945 µW/cm3 in the PDC exposures. The peak dose ranged from 6,739 to 27,298 Joules/cm3 and 21,306 to 80,941 Joules/cm3 in the AC and PDC exposures, respectively. The applied power ranged from 16.6 to 68.9 kWh in the AC exposures and from 22.2 to 86.4 kWh in the PDC exposures. Mortality ranged from 2.7 to 92.7% in the AC exposed groups and from 24.0 to 98.7% in PDC exposed groups. Mortality increased with corresponding increases in water temperature and exposure duration, and we observed more zebra mussel mortality in the PDC exposures. Exposures conducted with AC required less of a peak dose (Joules/cm3) but more applied power (kWh) to achieve the same level of adult zebra mussel mortality as corresponding PDC exposures. The results demonstrate that 20% duty cycle square-wave PDC requires less energy than sinusoidal AC to inducing the same level of adult zebra mussel mortality.

Bioelectrical Impedance and The Frequency Dependent Current Conduction Through Biological Tissues: A Short Review

NASA Astrophysics Data System (ADS)

Kanti Bera, Tushar

2018-03-01

Biological tissues are developed with biological cells which exhibit complex electrical impedance called electrical bioimpedance. Under an alternating electrical excitation the bioimpedance varies with the tissue anatomy, composition and the signal frequency. The current penetration and conduction paths vary with frequency of the applied signal. Bioimpedance spectroscopy is used to study the frequency response of the electrical impedance of biological materials noninvasively. In bioimpedance spectroscopy, a low amplitude electrical signal is injected to the tissue sample or body parts to characterization the sample in terms of its bioimpedance. The electrical current conduction phenomena, which is highly influenced by the tissue impedance and the signal frequency, is an important phenomena which should be studied to understand the bioimpedance techniques like bioelectrical impedance analysis (BIA), EIS, or else. In this paper the origin of bioelectrical impedance and current conduction phenomena has been reviewed to present a brief summary of bioelectrical impedance and the frequency dependent current conduction through biological tissues. Simulation studies are conducted with alternation current injection through a two dimensional model of biological tissues containing finite number of biological cells suspended in extracellular fluid. The paper demonstrates the simulation of alternating current conduction through biological tissues conducted by COMSOL Multiphysics. Simulation studies also show the frequency response of the tissue impedance for different tissue compositions.

A data mining method to facilitate SAR transfer.

PubMed

Wassermann, Anne Mai; Bajorath, Jürgen

2011-08-22

A challenging practical problem in medicinal chemistry is the transfer of SAR information from one chemical series to another. Currently, there are no computational methods available to rationalize or support this process. Herein, we present a data mining approach that enables the identification of alternative analog series with different core structures, corresponding substitution patterns, and comparable potency progression. Scaffolds can be exchanged between these series and new analogs suggested that incorporate preferred R-groups. The methodology can be applied to search for alternative analog series if one series is known or, alternatively, to systematically assess SAR transfer potential in compound databases.

[Magnetic therapy in treatment of patients with leg ulcers].

PubMed

Alekseenko, A V; Gusak, V V; Tarabanchuk, V V; Iftodiĭ, A G; Sherban, N G; Stoliar, V F

1998-01-01

Various magnetic (continuous current, alternating current and "running" impulse) fields were applied in 74 patients with trophic ulcers of lower limbs. 10-12 days after the beginning of the magnetic therapy wound surface has completely cleaned from necrotic tissues, surrounding inflammatory changes eliminated, epithelization of the wounds began. The most pronounced clinical effect was observed after the use of "running" impulse of magnetic field.

Eddy current NDE performance demonstrations using simulation tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maurice, L.; Costan, V.; Guillot, E.

2013-01-25

To carry out performance demonstrations of the Eddy-Current NDE processes applied on French nuclear power plants, EDF studies the possibility of using simulation tools as an alternative to measurements on steam generator tube mocks-up. This paper focuses on the strategy led by EDF to assess and use code{sub C}armel3D and Civa, on the case of Eddy-Current NDE on wears problem which may appear in the U-shape region of steam generator tubes due to the rubbing of anti-vibration bars.

Polarization curve measurements combined with potential probe sensing for determining current density distribution in vanadium redox-flow batteries

NASA Astrophysics Data System (ADS)

Becker, Maik; Bredemeyer, Niels; Tenhumberg, Nils; Turek, Thomas

2016-03-01

Potential probes are applied to vanadium redox-flow batteries for determination of effective felt resistance and current density distribution. During the measurement of polarization curves in 100 cm2 cells with different carbon felt compression rates, alternating potential steps at cell voltages between 0.6 V and 2.0 V are applied. Polarization curves are recorded at different flow rates and states of charge of the battery. Increasing compression rates lead to lower effective felt resistances and a more uniform resistance distribution. Low flow rates at high or low state of charge result in non-linear current density distribution with high gradients, while high flow rates give rise to a nearly linear behavior.

Current-induced alternating reversed dual-echo-steady-state for joint estimation of tissue relaxation and electrical properties.

PubMed

Lee, Hyunyeol; Sohn, Chul-Ho; Park, Jaeseok

2017-07-01

To develop a current-induced, alternating reversed dual-echo-steady-state-based magnetic resonance electrical impedance tomography for joint estimation of tissue relaxation and electrical properties. The proposed method reverses the readout gradient configuration of conventional, in which steady-state-free-precession (SSFP)-ECHO is produced earlier than SSFP-free-induction-decay (FID) while alternating current pulses are applied in between the two SSFPs to secure high sensitivity of SSFP-FID to injection current. Additionally, alternating reversed dual-echo-steady-state signals are modulated by employing variable flip angles over two orthogonal injections of current pulses. Ratiometric signal models are analytically constructed, from which T 1 , T 2 , and current-induced B z are jointly estimated by solving a nonlinear inverse problem for conductivity reconstruction. Numerical simulations and experimental studies are performed to investigate the feasibility of the proposed method in estimating relaxation parameters and conductivity. The proposed method, if compared with conventional magnetic resonance electrical impedance tomography, enables rapid data acquisition and simultaneous estimation of T 1 , T 2 , and current-induced B z , yielding a comparable level of signal-to-noise ratio in the parameter estimates while retaining a relative conductivity contrast. We successfully demonstrated the feasibility of the proposed method in jointly estimating tissue relaxation parameters as well as conductivity distributions. It can be a promising, rapid imaging strategy for quantitative conductivity estimation. Magn Reson Med 78:107-120, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

Renormalization of Einstein gravity through a derivative-dependent field redefinition

NASA Astrophysics Data System (ADS)

Slovick, Brian

2018-01-01

This work explores an alternative solution to the problem of renormalizability in Einstein gravity. In the proposed approach, Einstein gravity is transformed into the renormalizable theory of four-derivative gravity by applying a local field redefinition containing an infinite number of higher derivatives. It is also shown that the current-current amplitude is invariant with the field redefinition, and thus the unitarity of Einstein gravity is preserved.

Biobased alternatives to guar gum as tackifiers for hydromulch

USDA-ARS?s Scientific Manuscript database

Guar gum, obtained from guar [Cyamopsis tetragonoloba (L.) Taub.] seeds, is currently the principal gum used as a tackifier (binder) for hydraulically-applied mulches (hydromulches) used in erosion control. The oil industry’s increased use of guar gum in hydraulic fracturing together with lower glo...

Methods for Estimating Environmental Effects and Constraints on NexGen: High Density Case Study

NASA Technical Reports Server (NTRS)

Augustine, S.; Ermatinger, C.; Graham, M.; Thompson, T.

2010-01-01

This document provides a summary of the current methods developed by Metron Aviation for the estimate of environmental effects and constraints on the Next Generation Air Transportation System (NextGen). This body of work incorporates many of the key elements necessary to achieve such an estimate. Each section contains the background and motivation for the technical elements of the work, a description of the methods used, and possible next steps. The current methods described in this document were selected in an attempt to provide a good balance between accuracy and fairly rapid turn around times to best advance Joint Planning and Development Office (JPDO) System Modeling and Analysis Division (SMAD) objectives while also supporting the needs of the JPDO Environmental Working Group (EWG). In particular this document describes methods applied to support the High Density (HD) Case Study performed during the spring of 2008. A reference day (in 2006) is modeled to describe current system capabilities while the future demand is applied to multiple alternatives to analyze system performance. The major variables in the alternatives are operational/procedural capabilities for airport, terminal, and en route airspace along with projected improvements to airframe, engine and navigational equipment.

Time varying voltage combustion control and diagnostics sensor

DOEpatents

Chorpening, Benjamin T [Morgantown, WV; Thornton, Jimmy D [Morgantown, WV; Huckaby, E David [Morgantown, WV; Fincham, William [Fairmont, WV

2011-04-19

A time-varying voltage is applied to an electrode, or a pair of electrodes, of a sensor installed in a fuel nozzle disposed adjacent the combustion zone of a continuous combustion system, such as of the gas turbine engine type. The time-varying voltage induces a time-varying current in the flame which is measured and used to determine flame capacitance using AC electrical circuit analysis. Flame capacitance is used to accurately determine the position of the flame from the sensor and the fuel/air ratio. The fuel and/or air flow rate (s) is/are then adjusted to provide reduced flame instability problems such as flashback, combustion dynamics and lean blowout, as well as reduced emissions. The time-varying voltage may be an alternating voltage and the time-varying current may be an alternating current.

Training Effects of Alternated and Pulsed Currents on the Quadriceps Muscles of Athletes.

PubMed

Oliveira, Pedro; Modesto, Karenina Arrais Guida; Bottaro, Martim; Babault, Nicolas; Durigan, João Luiz Quagliotti

2018-05-22

The aim of the study was to evaluate the effects of 6 weeks training with different neuromuscular electrical stimulation (NMES) currents (medium alternated and low-frequency pulsed current) on muscle architecture and neuromuscular performance of competitive athletes. A double-blind controlled and randomized experimental study was carried out with 33 athletes (22.2±2.6 yrs, 74.7±9.8 kg, 176.8±6.0 cm), divided into 3 groups: mid-frequency current (MF, n=12), pulsed current (PC, n=11) and the control group (CG, n=10). Quadriceps maximal voluntary peak torque (PT) and corresponding vastus lateralis electromyographic activity, evoked torque (PT-NMES), vastus lateralis muscle thickness, fascicle length, pennation angle, and level of discomfort were assessed before and after the interventions. NMES training was performed 3 times per week and consisted of 18 sessions, 15 min/session, 6 s duration in each contraction interspersed with 18 s rest. After the training period, muscle thickness increased in the MF and PC groups (p<0.05). PT-NMES increased only in the PC group (p<0.05). All currents produced similar levels of discomfort (p>0.05). Quadriceps NMES training applied through alternated or pulsed currents produced similar effects in architecture and neuromuscular performance in competitive athletes. © Georg Thieme Verlag KG Stuttgart · New York.

Advancing practice relating to SEA alternatives

DOE Office of Scientific and Technical Information (OSTI.GOV)

González, Ainhoa, E-mail: agonzal@tcd.ie; Thérivel, Riki, E-mail: levett-therivel@phonecoop.coop; Fry, John, E-mail: john.fry@ucd.ie

Developing and assessing alternatives is a key and central stage to Strategic Environmental Assessment (SEA). However, research has repeatedly reported this stage as one of the most poorly undertaken aspects of the SEA process. Current practice limitations include belated consideration of reasonable alternatives, narrow scope of alternatives that often include unrealistic or retrofitted options, limited stakeholder and public involvement in their identification, assessment and selection, lack of systematic approaches to their assessment and comparison, and inadequate reporting of the ‘storyline’ on how they were identified, what the potential impacts are and why the preferred alternative was selected. These issues havemore » resulted in objections and judicial reviews. On the positive side, a number of good practice case studies enable extraction of key lessons and formulation of a set of general recommendations to advance practice in SEA alternatives. In this paper, practical guidance on the identification and development of alternatives, their assessment and comparison, selection of the preferred option, and documentation of the process and the reasons for selection is provided and discussed to frame good practice approaches. - Highlights: • Alternatives are one of the most poorly completed aspects of Strategic Environmental Assessment. • Current practice limitations need to be addressed to enhance SEA effectiveness. • A set of recommendations are extracted from good practice case studies. • These recommendations can be applied across jurisdictions and sectors and tailored as necessary.« less

EVALUATION OF BACTERIOLOGICAL INDICATORS OF BIOSOLIDS DISINFECTION

EPA Science Inventory

Under the current regulations (CFR 503), Class B biosolids may be land applied with certain site restrictions. One method for achieving Class B status is to raise the pH of the sludge to >12 for a minimum of 2 hours with an alkaline material (normally lime). Alternately, a Clas...

78 FR 78788 - Nondiscrimination in Programs or Activities Conducted by the United States Department of Agriculture

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... require that OASCR offer ADR services to complainants where appropriate. This amendment is intended to...'s Blueprint for Stronger Service. Offering ADR will expand the use of techniques currently applied... of agency program users. Alternative Dispute Resolution Services Offered to Program Complainants The...

Innovating Business Communication Courses in Oman: From Design to Implementation

ERIC Educational Resources Information Center

Dauletova, Victoria

2016-01-01

The article challenges the conventional formats applied by business and professional education in higher academic institutions in Oman. The shift from the current traditional educational paradigm to more effective and engaging approaches to instruction is proposed through the launch of an alternative teaching/learning model which aims at preparing…

Using expert judgments to explore robust alternatives for forest management under climate change.

PubMed

McDaniels, Timothy; Mills, Tamsin; Gregory, Robin; Ohlson, Dan

2012-12-01

We develop and apply a judgment-based approach to selecting robust alternatives, which are defined here as reasonably likely to achieve objectives, over a range of uncertainties. The intent is to develop an approach that is more practical in terms of data and analysis requirements than current approaches, informed by the literature and experience with probability elicitation and judgmental forecasting. The context involves decisions about managing forest lands that have been severely affected by mountain pine beetles in British Columbia, a pest infestation that is climate-exacerbated. A forest management decision was developed as the basis for the context, objectives, and alternatives for land management actions, to frame and condition the judgments. A wide range of climate forecasts, taken to represent the 10-90% levels on cumulative distributions for future climate, were developed to condition judgments. An elicitation instrument was developed, tested, and revised to serve as the basis for eliciting probabilistic three-point distributions regarding the performance of selected alternatives, over a set of relevant objectives, in the short and long term. The elicitations were conducted in a workshop comprising 14 regional forest management specialists. We employed the concept of stochastic dominance to help identify robust alternatives. We used extensive sensitivity analysis to explore the patterns in the judgments, and also considered the preferred alternatives for each individual expert. The results show that two alternatives that are more flexible than the current policies are judged more likely to perform better than the current alternatives on average in terms of stochastic dominance. The results suggest judgmental approaches to robust decision making deserve greater attention and testing. © 2012 Society for Risk Analysis.

Systems and Methods for Ejection of Ions from an Ion Trap

NASA Technical Reports Server (NTRS)

Cooks, Robert Graham (Inventor); Snyder, Dalton (Inventor)

2018-01-01

The invention generally relates to systems and methods for ejection of ions from an ion trap. In certain embodiments, systems and methods of the invention sum two different frequency signals into a single summed signal that is applied to an ion trap. In other embodiments, an amplitude of a single frequency signal is modulated as the single frequency signal is being applied to the ion trap. In other embodiments, a first alternating current (AC) signal is applied to an ion trap that varies as a function of time, while a constant radio frequency (RF) signal is applied to the ion trap.

Ionization tube simmer current circuit

DOEpatents

Steinkraus, R.F. Jr.

1994-12-13

A highly efficient flash lamp simmer current circuit utilizes a fifty percent duty cycle square wave pulse generator to pass a current over a current limiting inductor to a full wave rectifier. The DC output of the rectifier is then passed over a voltage smoothing capacitor through a reverse current blocking diode to a flash lamp tube to sustain ionization in the tube between discharges via a small simmer current. An alternate embodiment of the circuit combines the pulse generator and inductor in the form of an FET off line square wave generator with an impedance limited step up output transformer which is then applied to the full wave rectifier as before to yield a similar simmer current. 6 figures.

Ionization tube simmer current circuit

DOEpatents

Steinkraus, Jr., Robert F.

1994-01-01

A highly efficient flash lamp simmer current circuit utilizes a fifty percent duty cycle square wave pulse generator to pass a current over a current limiting inductor to a full wave rectifier. The DC output of the rectifier is then passed over a voltage smoothing capacitor through a reverse current blocking diode to a flash lamp tube to sustain ionization in the tube between discharges via a small simmer current. An alternate embodiment of the circuit combines the pulse generator and inductor in the form of an FET off line square wave generator with an impedance limited step up output transformer which is then applied to the full wave rectifier as before to yield a similar simmer current.

Comparison of current distributions in electroconvulsive therapy and transcranial magnetic stimulation

NASA Astrophysics Data System (ADS)

Sekino, Masaki; Ueno, Shoogo

2002-05-01

We compared current density distributions in electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) by numerical calculations. The model consisted of an air region and three types of tissues with different conductivities representing the brain, the skull, and the scalp. In the ECT model, electric currents were applied through electrodes with a voltage of 100 V. In the TMS model, a figure-eight coil (6 cm diameter per coil) was placed on the vertex of the head model. An alternating current with a peak intensity of 3.0 kA and a frequency of 4.2 kHz was applied to the coil. The maximum current densities inside the brain in ECT (bilateral electrode position) and TMS were 234 and 322 A/m2, respectively. The results indicate that magnetic stimulators can generate comparable current densities to ECT. While the skull significantly affected current distributions in ECT, TMS efficiently induced eddy currents in the brain. In addition, TMS is more beneficial than ECT because the localized current distribution reduces the risk of adverse side effects.

Fast Erase Method and Apparatus For Digital Media

NASA Technical Reports Server (NTRS)

Oakely, Ernest C. (Inventor)

2006-01-01

A non-contact fast erase method for erasing information stored on a magnetic or optical media. The magnetic media element includes a magnetic surface affixed to a toroidal conductor and stores information in a magnetic polarization pattern. The fast erase method includes applying an alternating current to a planar inductive element positioned near the toroidal conductor, inducing an alternating current in the toroidal conductor, and heating the magnetic surface to a temperature that exceeds the Curie-point so that information stored on the magnetic media element is permanently erased. The optical disc element stores information in a plurality of locations being defined by pits and lands in a toroidal conductive layer. The fast erase method includes similarly inducing a plurality of currents in the optical media element conductive layer and melting a predetermined portion of the conductive layer so that the information stored on the optical medium is destroyed.

An Alternating Current Electroosmotic Pump Based on Conical Nanopore Membranes.

PubMed

Wu, Xiaojian; Ramiah Rajasekaran, Pradeep; Martin, Charles R

2016-04-26

Electroosmotic flow (EOF) is used to pump solutions through microfluidic devices and capillary electrophoresis columns. We describe here an EOF pump based on membrane EOF rectification, an electrokinetic phenomenon we recently described. EOF rectification requires membranes with asymmetrically shaped pores, and conical pores in a polymeric membrane were used here. We show here that solution flow through the membrane can be achieved by applying a symmetrical sinusoidal voltage waveform across the membrane. This is possible because the alternating current (AC) carried by ions through the pore is rectified, and we previously showed that rectified currents yield EOF rectification. We have investigated the effect of both the magnitude and frequency of the voltage waveform on flow rate through the membrane, and we have measured the maximum operating pressure. Finally, we show that operating in AC mode offers potential advantages relative to conventional DC-mode EOF pumps.

A method for determining electrophoretic and electroosmotic mobilities using AC and DC electric field particle displacements.

PubMed

Oddy, M H; Santiago, J G

2004-01-01

We have developed a method for measuring the electrophoretic mobility of submicrometer, fluorescently labeled particles and the electroosmotic mobility of a microchannel. We derive explicit expressions for the unknown electrophoretic and the electroosmotic mobilities as a function of particle displacements resulting from alternating current (AC) and direct current (DC) applied electric fields. Images of particle displacements are captured using an epifluorescent microscope and a CCD camera. A custom image-processing code was developed to determine image streak lengths associated with AC measurements, and a custom particle tracking velocimetry (PTV) code was devised to determine DC particle displacements. Statistical analysis was applied to relate mobility estimates to measured particle displacement distributions.

75 FR 47524 - Notice of Request for a Revision of a Currently Approved Information Collection (Listeria...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-06

... Statement of Non-Discrimination The U.S. Department of Agriculture (USDA) prohibits discrimination in all of its programs and activities on the basis of race, color, national origin, gender, religion, age... apply to all programs.) Persons with disabilities who require alternative means for communication of...

Applying Problem Solving to Statistics and Consumer Mathematics.

ERIC Educational Resources Information Center

Hawaii Univ., Honolulu. Curriculum Research and Development Group.

This text is an example of a Selected Mathematics Applications (Level A) course, developed for the Hawaii State Department of Education. There are two basic parts to this document. Section one discusses the approach used to develop this course, and provides a brief description of current alternative materials and resources. No materials were found…

77 FR 53948 - Self-Regulatory Organizations; Chicago Mercantile Exchange Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

... proposes to amend the current fee schedule that applies to CME's OTC Interest Rate Swap (``IRS'') clearing offering. Specifically, CME will be adding; (i) An optional alternative fee schedule, (ii) progressive fee... changes relates to new progressive fee tiers. Under these changes, each calendar quarter, firms may...

Alternating current breakdown voltage of ice electret

NASA Astrophysics Data System (ADS)

Oshika, Y.; Tsuchiya, Y.; Okumura, T.; Muramoto, Y.

2017-09-01

Ice has low environmental impact. Our research objectives are to study the availability of ice as a dielectric insulating material at cryogenic temperatures. We focus on ferroelectric ice (iceXI) at cryogenic temperatures. The properties of iceXI, including its formation, are not clear. We attempted to obtain the polarized ice that was similar to iceXI under the applied voltage and cooling to 77 K. The polarized ice have a wide range of engineering applications as electronic materials at cryogenic temperatures. This polarized ice is called ice electret. The structural difference between ice electret and normal ice is only the positions of protons. The effects of the proton arrangement on the breakdown voltage of ice electret were shown because electrical properties are influenced by the structure of ice. We observed an alternating current (ac) breakdown voltage of ice electret and normal ice at 77 K. The mean and minimum ac breakdown voltage values of ice electret were higher than those of normal ice. We considered that the electrically weak part of the normal ice was improved by applied a direct electric field.

Combined Effect of Alternating Current Interference and Cathodic Protection on Pitting Corrosion and Stress Corrosion Cracking Behavior of X70 Pipeline Steel in Near-Neutral pH Environment.

PubMed

Wang, Liwei; Cheng, Lianjun; Li, Junru; Zhu, Zhifu; Bai, Shuowei; Cui, Zhongyu

2018-03-22

Influence of alternating current (AC) on pitting corrosion and stress corrosion cracking (SCC) behavior of X70 pipeline steel in the near-neutral pH environment under cathodic protection (CP) was investigated. Both corrosion and SCC are inhibited by -0.775 V SCE CP without AC interference. With the superimposition of AC current (1-10 mA/cm²), the direct current (DC) potential shifts negatively under the CP of -0.775 V SCE and the cathodic DC current decreases and shifts to the anodic direction. Under the CP potential of -0.95 V SCE and -1.2 V SCE , the applied AC current promotes the cathodic reaction and leads to the positive shift of DC potential and increase of cathodic current. Local anodic dissolution occurs attributing to the generated anodic current transients in the positive half-cycle of the AC current, resulting in the initiation of corrosion pits (0.6-2 μm in diameter). AC enhances the SCC susceptibility of X70 steel under -0.775 V SCE CP, attributing to the promotion of anodic dissolution and hydrogen evolution. Even an AC current as low as 1 mA/cm² can enhance the SCC susceptibility.

Lowering of the firing voltage and reducing of the discharge delay time in alternating current plasma display panels by a discontinuous spin-coated LaB{sub 6} film on the MgO protective layer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deng, Jiang, E-mail: dj78291@163.com; Zeng, Baoqing; Zhongshan Institute, University of Electronic Science and Technology of China, 528402 zhongshan

2014-03-15

A spin coated LaB{sub 6} discontinuous film is covered on MgO protective layer to improve the discharge performance of alternating current plasma display panels. Under the premise of high transmittance of more than 90%, a very small amount of polycrystal LaB{sub 6} powders added in an organic solvent are chosen as the coating solution. The discharge characteristics results show that with 250 torr 5% Xe-Ne pressure, the firing voltage and discharge delay time of the test panel with LaB{sub 6}/MgO double protective layer are decreased by 13.4% and 36.5%, respectively, compared with that of conventional MgO protective layer, likely owingmore » to the low work function of LaB{sub 6.} Furthermore, the aging time of the proposed structure is comparable to that of pure MgO protective layer. Therefore, it will not increase the production costs and is highly suitable to be applied for alternating current plasma display panels with low electrical power consumption.« less

76 FR 24850 - Notice of Request for a Revision of a Currently Approved Information Collection (Application for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

... discrimination in all its programs and activities on the basis of race, color, national origin, gender, religion... laboratories to maintain certain paperwork and records (9 CFR 439.20 & 590.580). The Agency uses this collected... prohibited bases apply to all programs.) Persons with disabilities who require alternative means for...

Determination of the Formula of a Hydrate: A Greener Alternative

ERIC Educational Resources Information Center

Klingshirn, Marc A.; Wyatt, Allison F.; Hanson, Robert M.; Spessard, Gary O.

2008-01-01

We are currently in the process of incorporating green chemistry throughout the chemistry curriculum. In this article we describe how we applied the principles of green chemistry in one of our first-semester general chemistry courses, specifically in relation to the determination of the formula of a hydrate. We utilize a copper hydrate salt that…

Teaching Interactions between Foreign Exchange Markets and Balance-of-Payments Flows: An Alternative Graphical Approach.

ERIC Educational Resources Information Center

Gaske, Dan

1992-01-01

Provides a graphical framework for presenting interactions among current account flows, capital account flows, and exchange rates. Suggests that the two type of flows must be considered separately in discussions of foreign exchange equilibrium and balance of payments flows. Supplies sample graphs and instructions for applying the framework to real…

Biofuels as an Alternative Energy Source for Aviation-A Survey

NASA Technical Reports Server (NTRS)

McDowellBomani, Bilal M.; Bulzan, Dan L.; Centeno-Gomez, Diana I.; Hendricks, Robert C.

2009-01-01

The use of biofuels has been gaining in popularity over the past few years because of their ability to reduce the dependence on fossil fuels. As a renewable energy source, biofuels can be a viable option for sustaining long-term energy needs if they are managed efficiently. We investigate past, present, and possible future biofuel alternatives currently being researched and applied around the world. More specifically, we investigate the use of ethanol, cellulosic ethanol, biodiesel (palm oil, algae, and halophytes), and synthetic fuel blends that can potentially be used as fuels for aviation and nonaerospace applications. We also investigate the processing of biomass via gasification, hydrolysis, and anaerobic digestion as a way to extract fuel oil from alternative biofuels sources.

Electro-dewatering of wastewater sludge: An investigation of the relationship between filtrate flow rate and electric current.

PubMed

Olivier, Jérémy; Conrardy, Jean-Baptiste; Mahmoud, Akrama; Vaxelaire, Jean

2015-10-01

Compared to conventional dewatering techniques, electrical assisted mechanical dewatering, also called electro-dewatering (EDW) is an alternative and an effective technology for the dewatering of sewage sludge with low energy consumption. The objectives of this study were to evaluate the dewatering performance and to determine the influence of the process parameters (e.g. applied electric current, applied voltage, and the initial amount of dry solids) on the kinetics of EDW-process for activated urban sludge. Also significant efforts have been devoted herein to provide comprehensive information about the EDW mechanisms and to understand the relationship between these operating conditions with regards to develop a qualitative and quantitative understanding model of the electro-dewatering process and then produce a robust design methodology. The results showed a very strong correlation between the applied electric current and the filtrate flow rate and consequently the electro-dewatering kinetics. A higher applied electric current leads to faster EDW kinetics and a higher final dry solids content. In contrast, the results of this work showed a significant enhancement of the dewatering kinetics by decreasing the mass of the dry solids introduced into the cell (commonly known as the sludge loading). Copyright © 2015 Elsevier Ltd. All rights reserved.

Photoelectrochemically driven self-assembly method

DOEpatents

Nielson, Gregory N.; Okandan, Murat

2017-01-17

Various technologies described herein pertain to assembling electronic devices into a microsystem. The electronic devices are disposed in a solution. Light can be applied to the electronic devices in the solution. The electronic devices can generate currents responsive to the light applied to the electronic devices in the solution, and the currents can cause electrochemical reactions that functionalize regions on surfaces of the electronic devices. Additionally or alternatively, the light applied to the electronic devices in the solution can cause the electronic devices to generate electric fields, which can orient the electronic devices and/or induce movement of the electronic devices with respect to a receiving substrate. Further, electrodes on a receiving substrate can be biased to attract and form connections with the electronic devices having the functionalized regions on the surfaces. The microsystem can include the receiving substrate and the electronic devices connected to the receiving substrate.

Electrical switching of an antiferromagnet

NASA Astrophysics Data System (ADS)

Jungwirth, Tomas

Louis Néel pointed out in his Nobel lecture that while abundant and interesting from theoretical viewpoint, antiferromagnets did not seem to have any applications. Indeed, the alternating directions of magnetic moments on individual atoms and the resulting zero net magnetization make antiferromagnets hard to control by tools common in ferromagnets. Strong coupling would be achieved if the externally generated field had a sign alternating on the scale of a lattice constant at which moments alternate in AFMs. However, generating such a field has been regarded unfeasible, hindering the research and applications of these abundant magnetic materials. We have recently predicted that relativistic quantum mechanics may offer staggered current induced fields with the sign alternating within the magnetic unit cell which can facilitate a reversible switching of an antiferromagnet by applying electrical currents with comparable efficiency to ferromagnets. Among suitable materials is a high Néel temperature antiferromagnet, tetragonal-phase CuMnAs, which we have recently synthesized in the form of single-crystal epilayers structurally compatible with common semiconductors. We demonstrate electrical writing and read-out, combined with the insensitivity to magnetic field perturbations, in a proof-of-concept antiferromagnetic memory device. We acknowledge support from European Research Council Advanced Grant No. 268066.

Basic and functional effects of transcranial Electrical Stimulation (tES)-An introduction.

PubMed

Yavari, Fatemeh; Jamil, Asif; Mosayebi Samani, Mohsen; Vidor, Liliane Pinto; Nitsche, Michael A

2018-02-01

Non-invasive brain stimulation (NIBS) has been gaining increased popularity in human neuroscience research during the last years. Among the emerging NIBS tools is transcranial electrical stimulation (tES), whose main modalities are transcranial direct, and alternating current stimulation (tDCS, tACS). In tES, a small current (usually less than 3mA) is delivered through the scalp. Depending on its shape, density, and duration, the applied current induces acute or long-lasting effects on excitability and activity of cerebral regions, and brain networks. tES is increasingly applied in different domains to (a) explore human brain physiology with regard to plasticity, and brain oscillations, (b) explore the impact of brain physiology on cognitive processes, and (c) treat clinical symptoms in neurological and psychiatric diseases. In this review, we give a broad overview of the main mechanisms and applications of these brain stimulation tools. Copyright © 2017 Elsevier Ltd. All rights reserved.

Fast charge implications: Pack and cell analysis and comparison

NASA Astrophysics Data System (ADS)

Tanim, Tanvir R.; Shirk, Matthew G.; Bewley, Randy L.; Dufek, Eric J.; Liaw, Bor Yann

2018-03-01

This study investigates the effect of 50-kW (about 2C) direct current fast charging on a full-size battery electric vehicle's battery pack in comparison to a pack exclusively charged at 3.3 kW, which is the common alternating current Level 2 charging power level. Comparable scaled charging protocols are also independently applied to individual cells at three different temperatures, 20 °C, 30 °C, and 40 °C, to perform a comparative analysis with the packs. Dominant cell-level aging modes were identified through incremental capacity analysis and compared with full packs to gain a clear understanding of additional key factors that affect pack aging. While the cell-level study showed a minor impact on performance due to direct current fast charging, the packs showed a significantly higher rate of capacity fade under similar charging protocols. This indicates that pack-level aging cannot be directly extrapolated from cell evaluation. Delayed fast charging, completing shortly before discharge, was found to have less of an impact on battery degradation than conventional alternating current Level 2 charging.

Alternating-Current InGaN/GaN Tunnel Junction Nanowire White-Light Emitting Diodes.

PubMed

Sadaf, S M; Ra, Y-H; Nguyen, H P T; Djavid, M; Mi, Z

2015-10-14

The current LED lighting technology relies on the use of a driver to convert alternating current (AC) to low-voltage direct current (DC) power, a resistive p-GaN contact layer to inject positive charge carriers (holes) for blue light emission, and rare-earth doped phosphors to down-convert blue photons into green/red light, which have been identified as some of the major factors limiting the device efficiency, light quality, and cost. Here, we show that multiple-active region phosphor-free InGaN nanowire white LEDs connected through a polarization engineered tunnel junction can fundamentally address the afore-described challenges. Such a p-GaN contact-free LED offers the benefit of carrier regeneration, leading to enhanced light intensity and reduced efficiency droop. Moreover, through the monolithic integration of p-GaN up and p-GaN down nanowire LED structures on the same substrate, we have demonstrated, for the first time, AC operated LEDs on a Si platform, which can operate efficiently in both polarities (positive and negative) of applied voltage.

Carrier velocity effect on carbon nanotube Schottky contact

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fathi, Amir, E-mail: fathi.amir@hotmail.com; Ahmadi, M. T., E-mail: mt.ahmadi@urmia.ac.ir; Ismail, Razali, E-mail: Razali@fke.utm.my

One of the most important drawbacks which caused the silicon based technologies to their technical limitations is the instability of their products at nano-level. On the other side, carbon based materials such as carbon nanotube (CNT) as alternative materials have been involved in scientific efforts. Some of the important advantages of CNTs over silicon components are high mechanical strength, high sensing capability and large surface-to-volume ratio. In this article, the model of CNT Schottky transistor current which is under exterior applied voltage is employed. This model shows that its current has a weak dependence on thermal velocity corresponding to themore » small applied voltage. The conditions are quite different for high bias voltages which are independent of temperature. Our results indicate that the current is increased by Fermi velocity, but the I–V curves will not have considerable changes with the variations in number of carriers. It means that the current doesn’t increase sharply by voltage variations over different number of carriers.« less

Theory and design of electrical rotating machinery

NASA Astrophysics Data System (ADS)

Carr, W. J., Jr.

1980-04-01

The objective of this program was to contribute toward new and improved rotating machines for Naval applications, with emphasis on superconducting machinery. Work has been performed on the theory of ac losses in multifilament superconductors and experiments were made to check the theory. A list of publications and abstracts of scientific papers published under the contract is given, and a review is given of the theory of losses. A macroscopic theory for superconductivity in multifilament superconductors was developed, and the theory was used to calculate the hysteresis and eddy current losses which occur in the presence of changing magnetic fields. Both the transverse field and the longitudinal field cases were considered, and also the self-field loss of an alternating transport current, along with some examples of the combined loss due to alternating applied field and transport current. The results are useful for the design of superconducting devices, such as superconducting motors and generators. A small amount of additional work was done on studies of novel homo- and heteropolar motors.

Use of electronic cigarettes and alternative tobacco products among Romanian adolescents.

PubMed

Nădăşan, Valentin; Foley, Kristie L; Pénzes, Melinda; Paulik, Edit; Mihăicuţă, Ştefan; Ábrám, Zoltán; Bálint, Jozsef; Urbán, Robert

2016-03-01

To assess socio-demographic and smoking-related correlates of e-cigarette and alternative tobacco products (ATPs) use in a multi-ethnic group of adolescents in Tîrgu Mures, Romania. The cross-sectional study included 1835 high school students from Tirgu Mures, Romania. Socio-demographic variables and data about smoking and e-cigarettes and ATP use were collected using an online questionnaire. Chi-square tests or one-way ANOVA were applied to compare never smokers, non-current smokers, and current smokers. Multiple logistic regression was conducted to determine the correlates of e-cigarettes and ATP use. The most frequently tried non-cigarette nicotine and tobacco products were e-cigarette (38.5 %), cigar (31.4 %) and waterpipe (21.1 %). Ever trying and current use of cigarettes were the most important correlates of e-cigarette and ATPs use. Sex, ethnicity, sensation seeking and perceived peer smoking were correlates of several ATPs use. The results of this study may inform the development of tailored tobacco control programs.

THE EFFECT OF LONG TERM WASTEWATER CROSS-CONNECTION'S EFFECT ON THE BIOFILM OF A SIMULATED WATER DISTRIBUTION SYSTEM

EPA Science Inventory

Under the current regulations (CFR 503), Class B biosolids may be land applied with certain site restrictions. One method for achieving Class B status is to raise the pH of the sludge to >12 for a minimum of 2 hours with an alkaline material (normally lime). Alternately, a Clas...

A Case Study on Reducing Children's Screen Time: The Project of Screen Free Week

ERIC Educational Resources Information Center

Kara, Hatice Gözde Ertürk

2018-01-01

The current study aims to direct children to alternative activities within a week period by applying the project of screen free week to voluntary families. The ultimate aim of the study is to reduce children's screen time. The instrumental case study method; one of the qualitative research methods, was employed. Five children attending the…

Nondestructive detection of decay in living trees

Treesearch

Bertil Larsson; Bengt Bengtsson; Mats Gustaffson

2004-01-01

We used a four-point resistivity method to detect wood decay in living trees. low-frequency alternating current was applied to the stem and the induced voltage measured between two points along the stem. The effective resistivity of the stem was estimated based on stem cross-sectional area. A comparison within a group of trees showed that trees with butt rot had an...

The logic of the floral transition: Reverse-engineering the switch controlling the identity of lateral organs.

PubMed

Dinh, Jean-Louis; Farcot, Etienne; Hodgman, Charlie

2017-09-01

Much laboratory work has been carried out to determine the gene regulatory network (GRN) that results in plant cells becoming flowers instead of leaves. However, this also involves the spatial distribution of different cell types, and poses the question of whether alternative networks could produce the same set of observed results. This issue has been addressed here through a survey of the published intercellular distribution of expressed regulatory genes and techniques both developed and applied to Boolean network models. This has uncovered a large number of models which are compatible with the currently available data. An exhaustive exploration had some success but proved to be unfeasible due to the massive number of alternative models, so genetic programming algorithms have also been employed. This approach allows exploration on the basis of both data-fitting criteria and parsimony of the regulatory processes, ruling out biologically unrealistic mechanisms. One of the conclusions is that, despite the multiplicity of acceptable models, an overall structure dominates, with differences mostly in alternative fine-grained regulatory interactions. The overall structure confirms the known interactions, including some that were not present in the training set, showing that current data are sufficient to determine the overall structure of the GRN. The model stresses the importance of relative spatial location, through explicit references to this aspect. This approach also provides a quantitative indication of how likely some regulatory interactions might be, and can be applied to the study of other developmental transitions.

Recovery and purification process development for monoclonal antibody production

PubMed Central

Ma, Junfen; Winter, Charles; Bayer, Robert

2010-01-01

Hundreds of therapeutic monoclonal antibodies (mAbs) are currently in development, and many companies have multiple antibodies in their pipelines. Current methodology used in recovery processes for these molecules are reviewed here. Basic unit operations such as harvest, Protein A affinity chromatography and additional polishing steps are surveyed. Alternative processes such as flocculation, precipitation and membrane chromatography are discussed. We also cover platform approaches to purification methods development, use of high throughput screening methods, and offer a view on future developments in purification methodology as applied to mAbs. PMID:20647768

Shape-retainment control using an antagonistic shape memory alloy system

NASA Astrophysics Data System (ADS)

Ikeda, T.; Sawamura, K.; Senba, A.; Tamayama, M.

2015-04-01

Since shape memory alloy (SMA) actuators can generate large force per unit weight, they are expected as one of the next generation actuators for aircraft. To keep a position of conventional control surfaces or morphing wings with SMA actuators, the SMA actuators must keep being heated, and the heating energy is not small. To save the energy, a new control method proposed for piezoelectric actuators utilizing hysteresis in deformation [Ikeda and Takahashi, Proc. SPIE 8689 (2013), 86890C] is applied to an antagonistic SMA system. By using the control method any position can be an equilibrium point within hysteresis of stress-strain diagrams. To confirm a feasibility of the control method, a fundamental experiment is performed. The SMA wires are heated by applying electric current to the wires. When a pulsed current is applied to the two SMA wires alternately, the equilibrium position changes between two positions alternately, and when a series of pulse whose amplitude increases gradually is applied to one SMA wire, the equilibrium position changes like a staircase. However, just after the pulse the position returns slightly, that is, overshoot takes place. To investigate such a behavior of the system, numerical simulation is also performed. The one-dimensional phase transformation model [Ikeda, Proc. SPIE 5757 (2005), 344-352] is used for a constitutive model of the SMA wires. The simulated result agrees with the experiment qualitatively, including the overshoot. By examining volume fraction of each phase, it is found that the overshoot is caused by that austenite phase transforms into stress-induced martensite phase during the cooling process after the pulse.

A Memory Based Model of Posttraumatic Stress Disorder: Evaluating Basic Assumptions Underlying the PTSD Diagnosis

PubMed Central

Rubin, David C.; Berntsen, Dorthe; Johansen, Malene Klindt

2009-01-01

In the mnemonic model of PTSD, the current memory of a negative event, not the event itself determines symptoms. The model is an alternative to the current event-based etiology of PTSD represented in the DSM. The model accounts for important and reliable findings that are often inconsistent with the current diagnostic view and that have been neglected by theoretical accounts of the disorder, including the following observations. The diagnosis needs objective information about the trauma and peritraumatic emotions, but uses retrospective memory reports that can have substantial biases. Negative events and emotions that do not satisfy the current diagnostic criteria for a trauma can be followed by symptoms that would otherwise qualify for PTSD. Predisposing factors that affect the current memory have large effects on symptoms. The inability-to-recall-an-important-aspect-of-the-trauma symptom does not correlate with other symptoms. Loss or enhancement of the trauma memory affects PTSD symptoms in predictable ways. Special mechanisms that apply only to traumatic memories are not needed, increasing parsimony and the knowledge that can be applied to understanding PTSD. PMID:18954211

Training Course for Power Operating Personnel. Lesson No. 6: Alternating-Current Generator Excitation.

ERIC Educational Resources Information Center

Department of the Interior, Denver, CO. Engineering and Research Center.

Subjects covered in this text are controlling the hydroelectric generator, generator excitation, basic principles of direct current generation, direction of current flow, basic alternating current generator, alternating and direct current voltage outputs, converting alternating current to direct current, review of the basic generator and…

AC electric field for rapid assembly of nanostructured polyaniline onto microsized gap for sensor devices.

PubMed

La Ferrara, Vera; Rametta, Gabriella; De Maria, Antonella

2015-07-01

Interconnected network of nanostructured polyaniline (PANI) is giving strong potential for enhancing device performances than bulk PANI counterparts. For nanostructured device processing, the main challenge is to get prototypes on large area by requiring precision, low cost and high rate assembly. Among processes meeting these requests, the alternate current electric fields are often used for nanostructure assembling. For the first time, we show the assembly of nanostructured PANI onto large electrode gaps (30-60 μm width) by applying alternate current electric fields, at low frequencies, to PANI particles dispersed in acetonitrile (ACN). An important advantage is the short assembly time, limited to 5-10 s, although electrode gaps are microsized. That encouraging result is due to a combination of forces, such as dielectrophoresis (DEP), induced-charge electrokinetic (ICEK) flow and alternate current electroosmotic (ACEO) flow, which speed up the assembly process when low frequencies and large electrode gaps are used. The main achievement of the present study is the development of ammonia sensors created by direct assembling of nanostructured PANI onto electrodes. Sensors exhibit high sensitivity to low gas concentrations as well as excellent reversibility at room temperature, even after storage in air. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Evaluation of SRB phenolic TPS material made by an alternate vendor

NASA Technical Reports Server (NTRS)

Karu, Z. S.

1982-01-01

Tests conducted to evaluate the adequacy of solid rocket booster (SRB) phenolic thermal protection system (TPS) material supplied by an alternate vendor chosen by United Space Boosters, Inc. (USBI), to replace the current phenolic TPS sections used thus far on the first four Shuttle flights. The phenolic TPS is applied mainly to the attach and kick rings of the solid rocket booster (SRB). Full-scale sectional models of both the attach and kick ring structure were made up with 0.0265 in. thick stainless steel thin skin covers with thermocouples on them to determine the heating rates. Such models were made up for both the forward and rear faces of the kick ring which has a different configuration on each side. The thin skins were replaced with the alternate phenolic TPS sections cut from flight hardware configuration phenolic parts as supplied by the new vendor. Two tests were performed for each configuration of the attach and kick rings and the samples were exposed to the flow for a duration that gave a heat load equivalent to that obtained in the series of runs made for the current line of phenolic TPS. The samples performed very well with no loss of any phenolic layers. The post-test samples looked better than those used to verify the current phenolic TPS.

Alternatives to national average income data as eligibility criteria for international subsidies: a social justice perspective.

PubMed

Shebaya, Sirine; Sutherland, Andrea; Levine, Orin; Faden, Ruth

2010-12-01

Current strategies to address global inequities in access to life-saving vaccines use averaged national income data to determine eligibility. While largely successful in the lowest income countries, we argue that this approach could lead to significant inefficiencies from the standpoint of justice if applied to middle-income countries, where income inequalities are large and lead to national averages that obscure truly needy populations. Instead, we suggest alternative indicators more sensitive to social justice concerns that merit consideration by policy-makers developing new initiatives to redress health inequities in middle-income countries. © 2009 Blackwell Publishing Ltd.

Thermoelectric converters for alternating current standards

NASA Astrophysics Data System (ADS)

Anatychuk, L. I.; Taschuk, D. D.

2012-06-01

Thermoelectric converters of alternating current remain priority instruments when creating standard equipment. This work presents the results of design and manufacture of alternating current converter for a military standard of alternating current in Ukraine. Results of simulation of temperature distribution in converter elements, ways of optimization to improve the accuracy of alternating current signal reproduction are presented. Results of metrological trials are given. The quality of thermoelectric material specially created for alternating current metrology is verified. The converter was used in alternating current standard for the frequency range from 10 Hz to 30 MHz. The efficiency of using thermoelectric signal converters in measuring instruments is confirmed.

Empowerment through agency-promoting dialogue: an explicit application of harm reduction theory to reframe HIV test counseling.

PubMed

Mattson, M

2000-01-01

The counseling that accompanies HIV testing can be an important prevention tool for encouraging people to practice safer sex to avoid AIDS, but there is scant research about how HIV test counseling operates in practice. This article critiques the current Centers for Disease Control and Prevention (CDC) protocol for HIV test counseling for not being genuinely client centered and ignoring the unique needs of clients and offers an alternative approach that adapts and explicitly applies the tenets of harm reduction theory (HRT). Excerpts from actual HIV test counseling sessions illustrate both the weaknesses in the current approach to HIV test counseling and project how the alternative theoretical perspective offered could provide counseling that encourages agency-promoting and empowering dialogue. The implications for the development of HRT as a health communication heuristic and a practical training and evaluation strategy are discussed along with limitations and future research directions.

Enhanced labeling of microalgae cellular lipids by application of an electric field generated by alternating current.

PubMed

Su, Li-Chien; Hsu, Yi-Hsiang; Wang, Hsiang-Yu

2012-05-01

An alternating current was used to generate an electric field to enhance the fluorescent labeling of microalgae cellular lipids with Nile red and LipidTOX. The decay of the fluorescence intensity of Chlorella vulgaris cells in 0 V/cm was more than 50% after 10 min, and the intensity variation was as high as 7% in 20s. At 2000 V/cm, the decay rate decreased to 1.22% per minute and the intensity fluctuation was less than 1% for LipidTOX-labeled cells. For Spirulina sp. cells at 0 V/cm, the fluorescence intensity increased by 10% after 10 min, whereas at 2000 V/cm, labeling was more rapid and fluorescence intensity doubled. These results show that applying an electric field can improve the quality of fluorescence detection by alleviating decay and fluctuation or by enhancing signal intensity. Copyright © 2012 Elsevier Ltd. All rights reserved.

An Inexpensive Bismuth-Petrolatum Dressing for Treatment of Burns

PubMed Central

Chattopadhyay, Arhana; Chang, Kathleen; Nguyen, Khoa; Galvez, Michael G.; Legrand, Anais; Davis, Christopher; McGoldrick, Rory; Long, Chao; Pham, Hung

2016-01-01

Background: Xeroform remains the current standard for treating superficial partial-thickness burns but can be prohibitively expensive in developing countries with prevalent burn injuries. This study (1) describes the production of an alternative low-cost dressing and (2) compares the alternative dressing and Xeroform using the metrics of cost-effectiveness, antimicrobial activity, and biocompatibility in vitro, and wound healing in vivo. Methods: To produce the alternative dressing, 3% bismuth tribromophenate powder was combined with petroleum jelly by hand and applied to Kerlix gauze. To assess cost-effectiveness, the unit costs of Xeroform and components of the alternative dressing were compared. To assess antimicrobial properties, the dressings were placed on agar plated with Escherichia coli and the Kirby-Bauer assay performed. To assess biocompatibility, the dressings were incubated with human dermal fibroblasts and cells stained with methylene blue. To assess in vivo wound healing, dressings were applied to excisional wounds on rats and the rate of re-epithelialization calculated. Results: The alternative dressing costs 34% of the least expensive brand of Xeroform. Antimicrobial assays showed that both dressings had similar bacteriostatic effects. Biocompatibility assays showed that there was no statistical difference (P < 0.05) in the cytotoxicity of Xeroform, alternative dressing, and Kerlix gauze. Finally, the in vivo healing model showed no statistical difference (P < 0.05) in mean re-epithelialization time between Xeroform (13.0 ± 1.6 days) and alternative dressing (13.5 ± 1.0 days). Conclusions: Xeroform is biocompatible, reduces infection, and enhances healing of burn wounds by preventing desiccation and mechanical trauma. Handmade petrolatum gauze may be a low-cost replacement for Xeroform. Future studies will focus on clinical trials in burn units. PMID:27482485

Clinical practice guidelines in complementary and alternative medicine. An analysis of opportunities and obstacles. Practice and Policy Guidelines Panel, National Institutes of Health Office of Alternative Medicine.

PubMed

1997-01-01

An estimated 1 of 3 Americans uses some form of complementary and alternative medicine (CAM), such as acupuncture, homeopathy, or herbal medicine. In 1995, the National Institutes of Health Office of Alternative Medicine convened an expert panel to examine the role of clinical practice guidelines in CAM. The panel concluded that CAM practices currently are unsuitable for the development of evidence-based practice guidelines, in part because of the lack of relevant outcomes data from well-designed clinical trials. Moreover, the notions of standardization and appropriateness, inherent in guideline development, face challenging methodologic problems when applied to CAM, which considers many different treatment practices appropriate and encourages highly individualized care. Due to different belief systems and divergent theories about the nature of health and illness, CAM disciplines have fundamental differences in how they define target conditions, causes of disease, interventions, and outcome measures of effectiveness. These differences are even more striking when compared with those used by Western medicine. The panel made a series of recommendations on strategies to strengthen the evidence base for future guideline development in CAM and to meet better the current information needs of clinicians, patients, and guideline developers who seek information about CAM treatments.

Probing Electrode Heterogeneity Using Fourier-Transformed Alternating Current Voltammetry: Application to a Dual-Electrode Configuration.

PubMed

Tan, Sze-Yin; Unwin, Patrick R; Macpherson, Julie V; Zhang, Jie; Bond, Alan M

2017-03-07

Quantitative studies of electron transfer processes at electrode/electrolyte interfaces, originally developed for homogeneous liquid mercury or metallic electrodes, are difficult to adapt to the spatially heterogeneous nanostructured electrode materials that are now commonly used in modern electrochemistry. In this study, the impact of surface heterogeneity on Fourier-transformed alternating current voltammetry (FTACV) has been investigated theoretically under the simplest possible conditions where no overlap of diffusion layers occurs and where numerical simulations based on a 1D diffusion model are sufficient to describe the mass transport problem. Experimental data that meet these requirements can be obtained with the aqueous [Ru(NH 3 ) 6 ] 3+/2+ redox process at a dual-electrode system comprised of electrically coupled but well-separated glassy carbon (GC) and boron-doped diamond (BDD) electrodes. Simulated and experimental FTACV data obtained with this electrode configuration, and where distinctly different heterogeneous charge transfer rate constants (k 0 values) apply at the individual GC and BDD electrode surfaces, are in excellent agreement. Principally, because of the far greater dependence of the AC current magnitude on k 0 , it is straightforward with the FTACV method to resolve electrochemical heterogeneities that are ∼1-2 orders of magnitude apart, as applies in the [Ru(NH 3 ) 6 ] 3+/2+ dual-electrode configuration experiments, without prior knowledge of the individual kinetic parameters (k 0 1 and k 0 2 ) or the electrode size ratio (θ 1 :θ 2 ). In direct current voltammetry, a difference in k 0 of >3 orders of magnitude is required to make this distinction.

Word identification in reading and the promise of subsymbolic psycholinguistics.

PubMed

Van Orden, G C; Pennington, B F; Stone, G O

1990-10-01

The vast literature concerning printed word identification either contradicts or provides ambiguous support for each of the central hypotheses of dual-process theory, the most widely accepted theory of printed word identification. In contrast, clear, positive support exists for an alternative subsymbolic approach that includes a central role for the process of phonologic coding. This subsymbolic account is developed around a covariant learning hypothesis, derived from a design principle common to current learning algorithms within the subsymbolic paradigm. Where this hypothesis applies, and it may apply broadly, it predicts a common empirical profile of development.

Method for making glass nonfogging

DOEpatents

Lord, David E.; Carter, Gary W.; Petrini, Richard R.

1979-01-01

A method for rendering glass nonfogging (to condensation fog) by sandwiching the glass between two electrodes such that the glass functions as the dielectric of a capacitor, a large alternating current (AC) voltage is applied across the electrodes for a selected time period causing the glass to absorb a charge, and the electrodes are removed. The glass absorbs a charge from the electrodes rendering it nonfogging. The glass surface is undamaged by application of the AC voltage, and normal optical properties are unaffected. This method can be applied to optical surfaces such as lenses, auto windshields, mirrors, etc., wherever condensation fog on glass is a problem.

Aternating current photovoltaic building block

DOEpatents

Bower, Ward Issac; Thomas, Michael G.; Ruby, Douglas S.

2004-06-15

A modular apparatus for and method of alternating current photovoltaic power generation comprising via a photovoltaic module, generating power in the form of direct current; and converting direct current to alternating current and exporting power via one or more power conversion and transfer units attached to the module, each unit comprising a unitary housing extending a length or width of the module, which housing comprises: contact means for receiving direct current from the module; one or more direct current-to-alternating current inverters; an alternating current bus; and contact means for receiving alternating current from the one or more inverters.

Estimated impacts of alternative Australian alcohol taxation structures on consumption, public health and government revenues.

PubMed

Doran, Christopher M; Byrnes, Joshua M; Cobiac, Linda J; Vandenberg, Brian; Vos, Theo

2013-11-04

To examine health and economic implications of modifying taxation of alcohol in Australia. Economic and epidemiological modelling of four scenarios for changing the current taxation of alcohol products, including: replacing the wine equalisation tax (WET) with a volumetric tax; applying an equal tax rate to all beverages equivalent to a 10% increase in the current excise applicable to spirits and ready-to-drink products; applying an excise tax rate that increases exponentially by 3% for every 1% increase in alcohol content above 3.2%; and applying a two-tiered volumetric tax. We used annual sales data and taxation rates for 2010 as the base case. Alcohol consumption, taxation revenue, disability-adjusted life-years (DALYs) averted and health care costs averted. In 2010, the Australian Government collected close to $8.6 billion from alcohol taxation. All four of the proposed variations to current rates of alcohol excise were shown to save money and more effectively reduce alcohol-related harm compared with the 2010 base case. Abolishing the WET and replacing it with a volumetric tax on wine would increase taxation revenue by $1.3 billion per year, reduce alcohol consumption by 1.3%, save $820 million in health care costs and avert 59 000 DALYs. The alternative scenarios would lead to even higher taxation receipts and greater reductions in alcohol use and harm. Our research findings suggest that any of the proposed variations to current rates of alcohol excise would be a cost-effective health care intervention; they thus reinforce the evidence that taxation is a cost-effective strategy. Of all the scenarios, perhaps the most politically feasible policy option at this point in time is to abolish the WET and replace it with a volumetric tax on wine. This analysis supports the recommendation of the National Preventative Health Taskforce and the Henry Review towards taxing alcohol according to alcohol content.

Fault current limiter and alternating current circuit breaker

DOEpatents

Boenig, Heinrich J.

1998-01-01

A solid-state circuit breaker and current limiter for a load served by an alternating current source having a source impedance, the solid-state circuit breaker and current limiter comprising a thyristor bridge interposed between the alternating current source and the load, the thyristor bridge having four thyristor legs and four nodes, with a first node connected to the alternating current source, and a second node connected to the load. A coil is connected from a third node to a fourth node, the coil having an impedance of a value calculated to limit the current flowing therethrough to a predetermined value. Control means are connected to the thyristor legs for limiting the alternating current flow to the load under fault conditions to a predetermined level, and for gating the thyristor bridge under fault conditions to quickly reduce alternating current flowing therethrough to zero and thereafter to maintain the thyristor bridge in an electrically open condition preventing the alternating current from flowing therethrough for a predetermined period of time.

Fault current limiter and alternating current circuit breaker

DOEpatents

Boenig, H.J.

1998-03-10

A solid-state circuit breaker and current limiter are disclosed for a load served by an alternating current source having a source impedance, the solid-state circuit breaker and current limiter comprising a thyristor bridge interposed between the alternating current source and the load, the thyristor bridge having four thyristor legs and four nodes, with a first node connected to the alternating current source, and a second node connected to the load. A coil is connected from a third node to a fourth node, the coil having an impedance of a value calculated to limit the current flowing therethrough to a predetermined value. Control means are connected to the thyristor legs for limiting the alternating current flow to the load under fault conditions to a predetermined level, and for gating the thyristor bridge under fault conditions to quickly reduce alternating current flowing therethrough to zero and thereafter to maintain the thyristor bridge in an electrically open condition preventing the alternating current from flowing therethrough for a predetermined period of time. 9 figs.

Monitoring tooth profile faults in epicyclic gearboxes using synchronously averaged motor currents: Mathematical modeling and experimental validation

NASA Astrophysics Data System (ADS)

Ottewill, J. R.; Ruszczyk, A.; Broda, D.

2017-02-01

Time-varying transmission paths and inaccessibility can increase the difficulty in both acquiring and processing vibration signals for the purpose of monitoring epicyclic gearboxes. Recent work has shown that the synchronous signal averaging approach may be applied to measured motor currents in order to diagnose tooth faults in parallel shaft gearboxes. In this paper we further develop the approach, so that it may also be applied to monitor tooth faults in epicyclic gearboxes. A low-degree-of-freedom model of an epicyclic gearbox which incorporates the possibility of simulating tooth faults, as well as any subsequent tooth contact loss due to these faults, is introduced. By combining this model with a simple space-phasor model of an induction motor it is possible to show that, in theory, tooth faults in epicyclic gearboxes may be identified from motor currents. Applying the synchronous averaging approach to experimentally recorded motor currents and angular displacements recorded from a shaft mounted encoder, validate this finding. Comparison between experiments and theory highlight the influence of operating conditions, backlash and shaft couplings on the transient response excited in the currents by the tooth fault. The results obtained suggest that the method may be a viable alternative or complement to more traditional methods for monitoring gearboxes. However, general observations also indicate that further investigations into the sensitivity and robustness of the method would be beneficial.

Semi-Supervised Novelty Detection with Adaptive Eigenbases, and Application to Radio Transients

NASA Technical Reports Server (NTRS)

Thompson, David R.; Majid, Walid A.; Reed, Colorado J.; Wagstaff, Kiri L.

2011-01-01

We present a semi-supervised online method for novelty detection and evaluate its performance for radio astronomy time series data. Our approach uses adaptive eigenbases to combine 1) prior knowledge about uninteresting signals with 2) online estimation of the current data properties to enable highly sensitive and precise detection of novel signals. We apply the method to the problem of detecting fast transient radio anomalies and compare it to current alternative algorithms. Tests based on observations from the Parkes Multibeam Survey show both effective detection of interesting rare events and robustness to known false alarm anomalies.

Calibration Designs for Non-Monolithic Wind Tunnel Force Balances

NASA Technical Reports Server (NTRS)

Johnson, Thomas H.; Parker, Peter A.; Landman, Drew

2010-01-01

This research paper investigates current experimental designs and regression models for calibrating internal wind tunnel force balances of non-monolithic design. Such calibration methods are necessary for this class of balance because it has an electrical response that is dependent upon the sign of the applied forces and moments. This dependency gives rise to discontinuities in the response surfaces that are not easily modeled using traditional response surface methodologies. An analysis of current recommended calibration models is shown to lead to correlated response model terms. Alternative modeling methods are explored which feature orthogonal or near-orthogonal terms.

Unexpected resonant response in [Fe(001)/Cr(001)]10/MgO(001) multilayers in a magnetic field.

PubMed

Aliev, F G; Pryadun, V V; Snoeck, E

2009-01-23

We observed unexpected resonant response in [Fe/Cr]10 multilayers epitaxially grown on MgO(100) substrates which exists only when both ac current and dc magnetic field are simultaneously applied. The magnitude of the resonances is determined by the multilayer magnetization proving their intrinsic character. The reduction of interface epitaxy leads to nonlinear dependence of the magnitude of resonances on the alternating current density. We speculate that the existence of the interface transition zone could facilitate the subatomic vibrations in thin metallic films and multilayers grown on bulk insulating substrates.

The Effects of Transcutaneous Electrical Stimulation on the Orthodontic Movement of Teeth.

DTIC Science & Technology

1985-05-01

Transcutaneous electrical nerve stimulation is an alternating electrical current applied k., ’ to the skin or gingiva with surface electrodes. Many...AD-AI68 889 THE EFFECTS OF TRANSCUTANEOUS ELECTRICAL STIMULATION ON 1/i THE ORTHODONTIC MOVEMENT OF TEETH(U) AIR FORCE INST OF TECH WRIGHT-PATTERSON...SPECIAL FIELD OF THE THESIS: of Transcutaneous Electrical Stimiu- Transcutaneous Electrical Stimulation lation on the Orthodontic Movement

Parameterization of the 3-PG model for Pinus elliottii stands using alternative methods to estimate fertility rating, biomass partitioning and canopy closure

Treesearch

Carlos A. Gonzalez-Benecke; Eric J. Jokela; Wendell P. Cropper; Rosvel Bracho; Daniel J. Leduc

2014-01-01

The forest simulation model, 3-PG, has been widely applied as a useful tool for predicting growth of forest species in many countries. The model has the capability to estimate the effects of management, climate and site characteristics on many stand attributes using easily available data. Currently, there is an increasing interest in estimating biomass and assessing...

Development of a Nonchromate Structural Adhesive Bond Primer

DTIC Science & Technology

2014-11-01

with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE NOV 2014 2. REPORT TYPE 3. DATES...Prevent corrosion of base metal • Applied to porous anodized surface • Overcoated with non-inhibited epoxy adhesive • High adhesive bond strength...primers •Long-running surveillance of chromate-free alternatives by UTC companies shows weak corrosion inhibition • (A) strontium chromate

Novel method for immunofluorescence staining of mammalian eggs using non-contact alternating-current electric-field mixing of microdroplets

PubMed Central

Hiromitsu, Shirasawa; Jin, Kumagai; Emiko, Sato; Katsuya, Kabashima; Yukiyo, Kumazawa; Wataru, Sato; Hiroshi, Miura; Ryuta, Nakamura; Hiroshi, Nanjo; Yoshihiro, Minamiya; Yoichi, Akagami; Yukihiro, Terada

2015-01-01

Recently, a new technique was developed for non-catalytically mixing microdroplets. In this method, an alternating-current (AC) electric field is used to promote the antigen–antibody reaction within the microdroplet. Previously, this technique has only been applied to histological examinations of flat structures, such as surgical specimens. In this study, we applied this technique for the first time to immunofluorescence staining of three-dimensional structures, specifically, mammalian eggs. We diluted an antibody against microtubules from 1:1,000 to 1:16,000, and compared the chromatic degree and extent of fading across dilutions. In addition, we varied the frequency of AC electric-field mixing from 5 Hz to 46 Hz and evaluated the effect on microtubule staining. Microtubules were more strongly stained after AC electric-field mixing for only 5 minutes, even when the concentration of primary antibody was 10 times lower than in conventional methods. AC electric-field mixing also alleviated microtubule fading. At all frequencies tested, AC electric-field mixing resulted in stronger microtubule staining than in controls. There was no clear difference in a microtubule staining between frequencies. These results suggest that the novel method could reduce antibody consumption and shorten immunofluorescence staining time. PMID:26477850

Detection and evaluation of weld defects in stainless steel using alternating current field measurement

NASA Astrophysics Data System (ADS)

Wei-Li, Ma, Weiping; Pan-Qi, Wen-jiao, Dou; Yuan, Xin'an; Yin, Xiaokang

2018-04-01

Stainless steel is widely used in nuclear power plants, such as various high-radioactive pool, tools storage and fuel transportation channel, and serves as an important barrier to stop the leakage of high-radioactive material. NonDestructive Evaluation (NDE) methods, eddy current testing (ET), ultrasonic examination (UT), penetration testing (PT) and hybrid detection method, etc., have been introduced into the inspection of a nuclear plant. In this paper, the Alternating Current Field Measurement (ACFM) was fully applied to detect and evaluate the defects in the welds of the stainless steel. Simulations were carried out on different defect types, crack lengths, and orientation to reveal the relationship between the signals and dimensions to determine whether methods could be validated by the experiment. A 3-axis ACFM probe was developed and three plates including 16 defects, which served in nuclear plant before, were examined by automatic detection equipment. The result shows that the minimum detectable crack length on the surface is 2mm and ACFM shows excellent inspection results for a weld in stainless steel and gives an encouraging prospect of broader application.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balser, S.; Sankar, S.; Miller, R.

In order to more fully integrate renewable resources, such as wind and solar, into the transmission system, additional capacity must be realized in the short term using the installed transmission capacity that exists today. The U.S. Department of Energy (DOE) and the National Renewable Energy Laboratory Transmission and Grid Integration Group supported this study to assemble the history of regulations and status of transmission technology to expand existing grid capacity. This report compiles data on various transmission technology methods and upgrades for increased capacity utilization of the existing transmission system and transmission corridors. The report discusses the technical merit ofmore » each method and explains how the method could be applied within the current regulatory structure to increase existing transmission conductor and/or corridor capacity. The history and current state of alternatives to new construction is presented for regulators, legislators, and other policy makers wrestling with issues surrounding integration of variable generation. Current regulations are assessed for opportunities to change them to promote grid expansion. To support consideration of these alternatives for expanding grid capacity, the report lists relevant rules, standards, and policy changes.« less

Evaluation of healthcare waste treatment/disposal alternatives by using multi-criteria decision-making techniques.

PubMed

Özkan, Aysun

2013-02-01

Healthcare waste should be managed carefully because of infected, pathological, etc. content especially in developing countries. Applied management systems must be the most appropriate solution from a technical, environmental, economic and social point of view. The main objective of this study was to analyse the current status of healthcare waste management in Turkey, and to investigate the most appropriate treatment/disposal option by using different decision-making techniques. For this purpose, five different healthcare waste treatment/disposal alternatives including incineration, microwaving, on-site sterilization, off-site sterilization and landfill were evaluated according to two multi-criteria decision-making techniques: analytic network process (ANP) and ELECTRE. In this context, benefits, costs and risks for the alternatives were taken into consideration. Furthermore, the prioritization and ranking of the alternatives were determined and compared for both methods. According to the comparisons, the off-site sterilization technique was found to be the most appropriate solution in both cases.

Electrical safety Q&A. A reference guide for the clinical engineer.

PubMed

2005-02-01

This guide, which ECRI developed to answer the electrical safety questions most frequently asked by member hospitals, features practical advice for addressing electrical safety concerns in the healthcare environment. Questions addressed include: STANDARDS AND APPROVALS: What electrical safety standards apply? How do NFPA 99 and IEC 60601-1 differ? What organizations approve medical devices? LEAKAGE CURRENT LIMITS AND TESTING: How are leakage current limits established? What limits apply to equipment used in the hospital? And how should the limits be applied in special cases, such as the use of PCs in the patient care area or equipment used in the clinical laboratory? ISOLATED POWER: What are its advantages and disadvantages, and is isolated power needed in the operating room? Other topics addressed include double insulation, ground-fault circuit interrupters (GFCIs), and requirements for medical devices used in the home. Supplementary articles discuss acceptable alternatives to UL listing, the use of Hospital Grade plugs, the limitations of leakage current testing of devices connected to isolated power systems, and the debate about whether to designate ORs as wet locations. Experienced clinical engineers should find this guide to be a handy reference, while those new to the field should find it to be a helpful educational resource.

Interplay between current driven ferromagnetism in charge ordered antiferromagnetic Pr0.5Ca0.5MnO3 and superconducting YBa2Cu3O7-δ thin film multilayer

NASA Astrophysics Data System (ADS)

Baisnab, Dipak Kumar; Sardar, Manas; Amaladass, E. P.; Vaidhyanathan, L. S.; Baskaran, R.

2018-07-01

Thin film multilayer heterostructure of alternate YBa2Cu3O7-δ (YBCO) and Pr0.5Ca0.5MnO3 (PCMO) with thickness of each layer ∼60 nm has been deposited on (100) oriented SrTiO3 substrate by Pulsed Laser Deposition technique. A half portion of the base YBCO layer was masked in situ using mechanical shadow mask and in the remaining half portion, five alternate layers of PCMO and YBCO thin films were deposited. Magnetoresistance measurements were carried out under externally applied magnetic field and injection current. A noticeable damped oscillation of the superconducting transition temperature (TC) of this multilayer with respect to magnetic field is seen. Curiously, the field at which the first minimum in TC occurs, decreases as an injection current is driven perpendicular/parallel to the multilayers. Both these phenomena indicate that ferromagnetic correlation can be induced in antiferromagnetic PCMO thin films by (1) external magnetic field, or (2) injection current. While (1) is well researched, our study indicates that ferromagnetism can be induced by small amount of current in PCMO thin films. This unusual behavior points towards the strongly correlated nature of electrons in PCMO.

Increasing the Value of an Alternative Monetary Reinforcer Reduces Cigarette Choice in Adolescents

PubMed Central

Tidey, Jennifer W.; Kahler, Christopher W.; Wray, Tyler B.; Colby, Suzanne M.

2015-01-01

Introduction: Smoking can be conceptualized as an operant behavior maintained by the reinforcing effects of cigarettes. Changing the magnitude and availability of alternative reinforcers should shift behavior away from smoking. Adults’ smoking behavior is sensitive to the magnitude and availability of alternative reinforcers; however, the extent to which the same is true for adolescents has not yet been shown in the laboratory. Methods: To test the sensitivity of adolescent smoking behavior to changes in the magnitude of alternative reinforcement, we gave adolescents who abstained overnight the opportunity to make 20 choices between receiving two puffs of their usual-brand cigarette or money. The magnitude of the monetary reinforcer was varied across sessions in counterbalanced order ($0.00, $0.10, and $0.50). Results: Results indicated that adolescents’ choices for puffs decreased as a function of increasing monetary reinforcer magnitude, while money choices increased. This effect was moderated by baseline smoking level and by gender, such that heavier-smoking participants and males made more cigarette choices when the alternative monetary value was zero, and decreased their choices more steeply in response to increasing monetary value. Conclusions: The current study validates a laboratory choice procedure for studying smoking in adolescents, and demonstrates that adolescent smoking behavior is sensitive to changes in the magnitude of concurrently available monetary reinforcers. The current paradigm can be adapted and applied to explore the effects of other variables that may affect cigarette choice in adolescents. PMID:25666814

High-Temperature Thermal Conductivity Measurement Apparatus Based on Guarded Hot Plate Method

NASA Astrophysics Data System (ADS)

Turzo-Andras, E.; Magyarlaki, T.

2017-10-01

An alternative calibration procedure has been applied using apparatus built in-house, created to optimize thermal conductivity measurements. The new approach compared to those of usual measurement procedures of thermal conductivity by guarded hot plate (GHP) consists of modified design of the apparatus, modified position of the temperature sensors and new conception in the calculation method, applying the temperature at the inlet section of the specimen instead of the temperature difference across the specimen. This alternative technique is suitable for eliminating the effect of thermal contact resistance arising between a rigid specimen and the heated plate, as well as accurate determination of the specimen temperature and of the heat loss at the lateral edge of the specimen. This paper presents an overview of the specific characteristics of the newly developed "high-temperature thermal conductivity measurement apparatus" based on the GHP method, as well as how the major difficulties are handled in the case of this apparatus, as compared to the common GHP method that conforms to current international standards.

Quantitative assessment of specific defects in roasted ground coffee via infrared-photoacoustic spectroscopy.

PubMed

Dias, Rafael Carlos Eloy; Valderrama, Patrícia; Março, Paulo Henrique; Dos Santos Scholz, Maria Brigida; Edelmann, Michael; Yeretzian, Chahan

2018-07-30

Chemical analyses and sensory evaluation are the most applied methods for quality control of roasted and ground coffee (RG). However, faster alternatives would be highly valuable. Here, we applied infrared-photoacoustic spectroscopy (FTIR-PAS) on RG powder. Mixtures of specific defective beans were blended with healthy (defect-free) Coffea arabica and Coffea canephora bases in specific ratios, forming different classes of blends. Principal Component Analysis allowed predicting the amount/fraction and nature of the defects in blends while partial Least Squares Discriminant Analysis revealed similarities between blends (=samples). A successful predictive model was obtained using six classes of blends. The model could classify 100% of the samples into four classes. The specificities were higher than 0.9. Application of FTIR-PAS on RG coffee to characterize and classify blends has shown to be an accurate, easy, quick and "green" alternative to current methods. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

30 CFR 75.900 - Low- and medium-voltage circuits serving three-phase alternating current equipment; circuit...

Code of Federal Regulations, 2011 CFR

2011-07-01

...-phase alternating current equipment; circuit breakers. 75.900 Section 75.900 Mineral Resources MINE... Low- and medium-voltage circuits serving three-phase alternating current equipment; circuit breakers. [Statutory Provisions] Low- and medium-voltage power circuits serving three-phase alternating current...

HIV Epidemic Appraisals for Assisting in the Design of Effective Prevention Programmes: Shifting the Paradigm Back to Basics

PubMed Central

Mishra, Sharmistha; Sgaier, Sema K.; Thompson, Laura H.; Moses, Stephen; Ramesh, B. M.; Alary, Michel; Wilson, David; Blanchard, James F.

2012-01-01

Background To design HIV prevention programmes, it is critical to understand the temporal and geographic aspects of the local epidemic and to address the key behaviours that drive HIV transmission. Two methods have been developed to appraise HIV epidemics and guide prevention strategies. The numerical proxy method classifies epidemics based on current HIV prevalence thresholds. The Modes of Transmission (MOT) model estimates the distribution of incidence over one year among risk-groups. Both methods focus on the current state of an epidemic and provide short-term metrics which may not capture the epidemiologic drivers. Through a detailed analysis of country and sub-national data, we explore the limitations of the two traditional methods and propose an alternative approach. Methods and Findings We compared outputs of the traditional methods in five countries for which results were published, and applied the numeric and MOT model to India and six districts within India. We discovered three limitations of the current methods for epidemic appraisal: (1) their results failed to identify the key behaviours that drive the epidemic; (2) they were difficult to apply to local epidemics with heterogeneity across district-level administrative units; and (3) the MOT model was highly sensitive to input parameters, many of which required extraction from non-regional sources. We developed an alternative decision-tree framework for HIV epidemic appraisals, based on a qualitative understanding of epidemiologic drivers, and demonstrated its applicability in India. The alternative framework offered a logical algorithm to characterize epidemics; it required minimal but key data. Conclusions Traditional appraisals that utilize the distribution of prevalent and incident HIV infections in the short-term could misguide prevention priorities and potentially impede efforts to halt the trajectory of the HIV epidemic. An approach that characterizes local transmission dynamics provides a potentially more effective tool with which policy makers can design intervention programmes. PMID:22396756

Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo.

PubMed

Chhatbar, Pratik Y; Kautz, Steven A; Takacs, Istvan; Rowland, Nathan C; Revuelta, Gonzalo J; George, Mark S; Bikson, Marom; Feng, Wuwei

2018-03-13

Transcranial direct current stimulation (tDCS) is a promising brain modulation technique for several disease conditions. With this technique, some portion of the current penetrates through the scalp to the cortex and modulates cortical excitability, but a recent human cadaver study questions the amount. This insufficient intracerebral penetration of currents may partially explain the inconsistent and mixed results in tDCS studies to date. Experimental validation of a transcranial alternating current stimulation-generated electric field (EF) in vivo has been performed on the cortical (using electrocorticography, ECoG, electrodes), subcortical (using stereo electroencephalography, SEEG, electrodes) and deeper thalamic/subthalamic levels (using DBS electrodes). However, tDCS-generated EF measurements have never been attempted. We aimed to demonstrate that tDCS generates biologically relevant EF as deep as the subthalamic level in vivo. Patients with movement disorders who have implanted deep brain stimulation (DBS) electrodes serve as a natural experimental model for thalamic/subthalamic recordings of tDCS-generated EF. We measured voltage changes from DBS electrodes and body resistance from tDCS electrodes in three subjects while applying direct current to the scalp at 2 mA and 4 mA over two tDCS montages. Voltage changes at the level of deep nuclei changed proportionally with the level of applied current and varied with different tDCS montages. Our findings suggest that scalp-applied tDCS generates biologically relevant EF. Incorporation of these experimental results may improve finite element analysis (FEA)-based models. Copyright © 2018 Elsevier Inc. All rights reserved.

30 CFR 77.701-1 - Approved methods of grounding of equipment receiving power from ungrounded alternating current...

Code of Federal Regulations, 2011 CFR

2011-07-01

... receiving power from ungrounded alternating current power systems. 77.701-1 Section 77.701-1 Mineral...-1 Approved methods of grounding of equipment receiving power from ungrounded alternating current... receiving power from ungrounded alternating current power systems, the following methods of grounding will...

30 CFR 75.701-1 - Approved methods of grounding of equipment receiving power from ungrounded alternating current...

Code of Federal Regulations, 2011 CFR

2011-07-01

... receiving power from ungrounded alternating current power systems. 75.701-1 Section 75.701-1 Mineral... receiving power from ungrounded alternating current power systems. For purposes of grounding metallic frames, casings and other enclosures of equipment receiving power from ungrounded alternating current power...

30 CFR 75.701-1 - Approved methods of grounding of equipment receiving power from ungrounded alternating current...

Code of Federal Regulations, 2010 CFR

2010-07-01

... receiving power from ungrounded alternating current power systems. 75.701-1 Section 75.701-1 Mineral... receiving power from ungrounded alternating current power systems. For purposes of grounding metallic frames, casings and other enclosures of equipment receiving power from ungrounded alternating current power...

30 CFR 77.701-1 - Approved methods of grounding of equipment receiving power from ungrounded alternating current...

Code of Federal Regulations, 2010 CFR

2010-07-01

... receiving power from ungrounded alternating current power systems. 77.701-1 Section 77.701-1 Mineral...-1 Approved methods of grounding of equipment receiving power from ungrounded alternating current... receiving power from ungrounded alternating current power systems, the following methods of grounding will...

30 CFR 77.900 - Low- and medium-voltage circuits serving portable or mobile three-phase alternating current...

Code of Federal Regulations, 2011 CFR

2011-07-01

... portable or mobile three-phase alternating current equipment; circuit breakers. 77.900 Section 77.900... mobile three-phase alternating current equipment; circuit breakers. Low- and medium-voltage circuits supplying power to portable or mobile three-phase alternating current equipment shall be protected by...

Biotechnology for the extractive metals industries

NASA Astrophysics Data System (ADS)

Brierley, James A.

1990-01-01

Biotechnology is an alternative process for the extraction of metals, the beneficiation of ores, and the recovery of metals from aqueous systems. Currently, microbial-based processes are used for leaching copper and uranium, enhancing the recovery of gold from refractory ores, and treating industrial wastewater to recover metal values. Future developments, emanating from fundamental and applied research and advances through genetic engineering, are expected to increase the use and efficiency of these biotechnological processes.

Review of virtual reality treatment for mental health.

PubMed

Gourlay, D; Lun, K C; Liya, G

2001-01-01

This paper describes recent research that proposes virtual reality techniques as a therapy for patients with cognitive and psychological problems. Specifically this applies to victims of conditions such as traumatic brain injury, Alzheimers and Parkinsons. Additionally virtual reality therapy offers an alternative to current desensitization techniques for the treatment of phobias Some important issues are examined including means of user interaction, skills transfer to the real world, and side-effects of virtual reality exposure.

Electrically tunable tunneling rectification magnetoresistance in magnetic tunneling junctions with asymmetric barriers.

PubMed

Wang, Jing; Huang, Qikun; Shi, Peng; Zhang, Kun; Tian, Yufeng; Yan, Shishen; Chen, Yanxue; Liu, Guolei; Kang, Shishou; Mei, Liangmo

2017-10-26

The development of multifunctional spintronic devices requires simultaneous control of multiple degrees of freedom of electrons, such as charge, spin and orbit, and especially a new physical functionality can be realized by combining two or more different physical mechanisms in one specific device. Here, we report the realization of novel tunneling rectification magnetoresistance (TRMR), where the charge-related rectification and spin-dependent tunneling magnetoresistance are integrated in Co/CoO-ZnO/Co magnetic tunneling junctions with asymmetric tunneling barriers. Moreover, by simultaneously applying direct current and alternating current to the devices, the TRMR has been remarkably tuned in the range from -300% to 2200% at low temperature. This proof-of-concept investigation provides an unexplored avenue towards electrical and magnetic control of charge and spin, which may apply to other heterojunctions to give rise to more fascinating emergent functionalities for future spintronics applications.

Importance of Survey Design for Studying the Epidemiology of Emerging Tobacco Product Use Among Youth.

PubMed

Delnevo, Cristine D; Gundersen, Daniel A; Manderski, Michelle T B; Giovenco, Daniel P; Giovino, Gary A

2017-08-15

Accurate surveillance is critical for monitoring the epidemiology of emerging tobacco products in the United States, and survey science suggests that survey response format can impact prevalence estimates. We utilized data from the 2014 New Jersey Youth Tobacco Survey (n = 3,909) to compare estimates of the prevalence of 4 behaviors (ever hookah use, current hookah use, ever e-cigarette use, and current e-cigarette use) among New Jersey high school students, as assessed using "check-all-that-apply" questions, with estimates measured by means of "forced-choice" questions. Measurement discrepancies were apparent for all 4 outcomes, with the forced-choice questions yielding prevalence estimates approximately twice those of the check-all-that-apply questions, and agreement was fair to moderate. The sensitivity of the check-all-that-apply questions, treating the forced-choice format as the "gold standard," ranged from 38.1% (current hookah use) to 58.3% (ever e-cigarette use), indicating substantial false-negative rates. These findings highlight the impact of question response format on prevalence estimates of emerging tobacco products among youth and suggest that estimates generated by means of check-all-that-apply questions may be biased downward. Alternative survey designs should be considered to avoid check-all-that-apply response formats, and researchers should use caution when interpreting tobacco use data obtained from check-all-that-apply formats. © The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Applying the cell-based coagulation model in the management of critical bleeding.

PubMed

Ho, K M; Pavey, W

2017-03-01

The cell-based coagulation model was proposed 15 years ago, yet has not been applied commonly in the management of critical bleeding. Nevertheless, this alternative model may better explain the physiological basis of current coagulation management during critical bleeding. In this article we describe the limitations of the traditional coagulation protein cascade and standard coagulation tests, and explain the potential advantages of applying the cell-based model in current coagulation management strategies. The cell-based coagulation model builds on the traditional coagulation model and explains many recent clinical observations and research findings related to critical bleeding unexplained by the traditional model, including the encouraging results of using empirical 1:1:1 fresh frozen plasma:platelets:red blood cells transfusion strategy, and the use of viscoelastic and platelet function tests in patients with critical bleeding. From a practical perspective, applying the cell-based coagulation model also explains why new direct oral anticoagulants are effective systemic anticoagulants even without affecting activated partial thromboplastin time or the International Normalized Ratio in a dose-related fashion. The cell-based coagulation model represents the most cohesive scientific framework on which we can understand and manage coagulation during critical bleeding.

Whole Wafer Design and Fabrication for the Alignment of Nanostructures for Chemical Sensor Applications

NASA Technical Reports Server (NTRS)

Biaggi-Labiosa, Azlin M.; Hunter, Gary W.

2013-01-01

A major objective in aerospace sensor development is to produce sensors that are small in size, easy to batch fabricate and low in cost, and have low power consumption The fabrication of chemical sensors involving nanostructured materials can provide these properties as well as the potential for the development of sensor systems with unique properties and improved performance. However, the fabrication and processing of nanostructures for sensor applications currently is limited in the ability to control their location on the sensor. Currently, our group at NASA Glenn Research Center has demonstrated the controlled placement of nanostructures in sensors using a sawtooth patterned electrode design. With this design the nanostructures are aligned between opposing sawtooth electrodes by applying an alternating current.

Bi-frontal transcranial alternating current stimulation in the ripple range reduced overnight forgetting.

PubMed

Ambrus, Géza Gergely; Pisoni, Alberto; Primaßin, Annika; Turi, Zsolt; Paulus, Walter; Antal, Andrea

2015-01-01

High frequency oscillations in the hippocampal structures recorded during sleep have been proved to be essential for long-term episodic memory consolidation in both animals and in humans. The aim of this study was to test if transcranial Alternating Current Stimulation (tACS) of the dorsolateral prefrontal cortex (DLPFC) in the hippocampal ripple range, applied bi-frontally during encoding, could modulate declarative memory performance, measured immediately after encoding, and after a night's sleep. An associative word-pair learning test was used. During an evening encoding phase, participants received 1 mA 140 Hz tACS or sham stimulation over both DLPFCs for 10 min while being presented twice with a list of word-pairs. Cued recall performance was investigated 10 min after training and the morning following the training session. Forgetting from evening to morning was observed in the sham condition, but not in the 140 Hz stimulation condition. 140 Hz tACS during encoding may have an effect on the consolidation of declarative material.

Understanding and applying open-path optical sensing data

NASA Astrophysics Data System (ADS)

Virag, Peter; Kricks, Robert J.

1999-02-01

During the last 10 years, open-path air monitors have evolved to yield reliable and effective measurements of single and multiple compounds on a real-time basis. To many individuals within the optical remote sensing community, the attributes of open-path and its the potential uses seem unlimited. Then why has the market has been stagnant for the last few years? The reason may center on how open-path information is applied and how well the end user understands that information. We constantly try to compare open-path data to risk/health or safety levels that are based for use at a single point and for a specific averaging period often far longer than a typical open-path data point. Often this approach is perceived as putting a square peg in a round hole. This perception may be well founded, as open-path data at times may need to go through extensive data manipulation and assumptions before it can be applied. This paper will review pervious open-path monitoring programs and their success in applying the data collected. We will also look at how open-path data is being currently used, some previous pitfalls in data use, alternate methods of data interpretation, and how open-path data can be best practically applied to fit current needs.

Training needs for toxicity testing in the 21st century: a survey-informed analysis.

PubMed

Lapenna, Silvia; Gabbert, Silke; Worth, Andrew

2012-12-01

Current training needs on the use of alternative methods in predictive toxicology, including new approaches based on mode-of-action (MoA) and adverse outcome pathway (AOP) concepts, are expected to evolve rapidly. In order to gain insight into stakeholder preferences for training, the European Commission's Joint Research Centre (JRC) conducted a single-question survey with twelve experts in regulatory agencies, industry, national research organisations, NGOs and consultancies. Stakeholder responses were evaluated by means of theory-based qualitative data analysis. Overall, a set of training topics were identified that relate both to general background information and to guidance for applying alternative testing methods. In particular, for the use of in silico methods, stakeholders emphasised the need for training on data integration and evaluation, in order to increase confidence in applying these methods for regulatory purposes. Although the survey does not claim to offer an exhaustive overview of the training requirements, its findings support the conclusion that the development of well-targeted and tailor-made training opportunities that inform about the usefulness of alternative methods, in particular those that offer practical experience in the application of in silico methods, deserves more attention. This should be complemented by transparent information and guidance on the interpretation of the results generated by these methods and software tools. 2012 FRAME.

Analysis of Family Structures Reveals Robustness or Sensitivity of Bursting Activity to Parameter Variations in a Half-Center Oscillator (HCO) Model.

PubMed

Doloc-Mihu, Anca; Calabrese, Ronald L

2016-01-01

The underlying mechanisms that support robustness in neuronal networks are as yet unknown. However, recent studies provide evidence that neuronal networks are robust to natural variations, modulation, and environmental perturbations of parameters, such as maximal conductances of intrinsic membrane and synaptic currents. Here we sought a method for assessing robustness, which might easily be applied to large brute-force databases of model instances. Starting with groups of instances with appropriate activity (e.g., tonic spiking), our method classifies instances into much smaller subgroups, called families, in which all members vary only by the one parameter that defines the family. By analyzing the structures of families, we developed measures of robustness for activity type. Then, we applied these measures to our previously developed model database, HCO-db, of a two-neuron half-center oscillator (HCO), a neuronal microcircuit from the leech heartbeat central pattern generator where the appropriate activity type is alternating bursting. In HCO-db, the maximal conductances of five intrinsic and two synaptic currents were varied over eight values (leak reversal potential also varied, five values). We focused on how variations of particular conductance parameters maintain normal alternating bursting activity while still allowing for functional modulation of period and spike frequency. We explored the trade-off between robustness of activity type and desirable change in activity characteristics when intrinsic conductances are altered and identified the hyperpolarization-activated (h) current as an ideal target for modulation. We also identified ensembles of model instances that closely approximate physiological activity and can be used in future modeling studies.

Driving Force of Plasma Bullet in Atmospheric-Pressure Plasma

NASA Astrophysics Data System (ADS)

Yambe, Kiyoyuki; Masuda, Seiya; Kondo, Shoma

2018-06-01

When plasma is generated by applying high-voltage alternating current (AC), the driving force of the temporally and spatially varying electric field is applied to the plasma. The strength of the driving force of the plasma at each spatial position is different because the electrons constituting the atmospheric-pressure nonequilibrium (cold) plasma move at a high speed in space. If the force applied to the plasma is accelerated only by the driving force, the plasma will be accelerated infinitely. The equilibrium between the driving force and the restricting force due to the collision between the plasma and neutral particles determines the inertial force and the drift velocity of the plasma. Consequently, the drift velocity depends on the strength of the time-averaged AC electric field. The pressure applied by the AC electric field equilibrates with the plasma pressure. From the law of conservation of energy, the pressure equilibrium is maintained by varying the drift velocity of the plasma.

Comparison of bioactive chemical space networks generated using substructure- and fingerprint-based measures of molecular similarity

NASA Astrophysics Data System (ADS)

Zhang, Bijun; Vogt, Martin; Maggiora, Gerald M.; Bajorath, Jürgen

2015-07-01

Chemical space networks (CSNs) have recently been introduced as a conceptual alternative to coordinate-based representations of chemical space. CSNs were initially designed as threshold networks using the Tanimoto coefficient as a continuous similarity measure. The analysis of CSNs generated from sets of bioactive compounds revealed that many statistical properties were strongly dependent on their edge density. While it was difficult to compare CSNs at pre-defined similarity threshold values, CSNs with constant edge density were directly comparable. In the current study, alternative CSN representations were constructed by applying the matched molecular pair (MMP) formalism as a substructure-based similarity criterion. For more than 150 compound activity classes, MMP-based CSNs (MMP-CSNs) were compared to corresponding threshold CSNs (THR-CSNs) at a constant edge density by applying different parameters from network science, measures of community structure distributions, and indicators of structure-activity relationship (SAR) information content. MMP-CSNs were found to be an attractive alternative to THR-CSNs, yielding low edge densities and well-resolved topologies. MMP-CSNs and corresponding THR-CSNs often had similar topology and closely corresponding community structures, although there was only limited overlap in similarity relationships. The homophily principle from network science was shown to affect MMP-CSNs and THR-CSNs in different ways, despite the presence of conserved topological features. Moreover, activity cliff distributions in alternative CSN designs markedly differed, which has important implications for SAR analysis.

Increasing the Value of an Alternative Monetary Reinforcer Reduces Cigarette Choice in Adolescents.

PubMed

Cassidy, Rachel N; Tidey, Jennifer W; Kahler, Christopher W; Wray, Tyler B; Colby, Suzanne M

2015-12-01

Smoking can be conceptualized as an operant behavior maintained by the reinforcing effects of cigarettes. Changing the magnitude and availability of alternative reinforcers should shift behavior away from smoking. Adults' smoking behavior is sensitive to the magnitude and availability of alternative reinforcers; however, the extent to which the same is true for adolescents has not yet been shown in the laboratory. To test the sensitivity of adolescent smoking behavior to changes in the magnitude of alternative reinforcement, we gave adolescents who abstained overnight the opportunity to make 20 choices between receiving two puffs of their usual-brand cigarette or money. The magnitude of the monetary reinforcer was varied across sessions in counterbalanced order ($0.00, $0.10, and $0.50). Results indicated that adolescents' choices for puffs decreased as a function of increasing monetary reinforcer magnitude, while money choices increased. This effect was moderated by baseline smoking level and by gender, such that heavier-smoking participants and males made more cigarette choices when the alternative monetary value was zero, and decreased their choices more steeply in response to increasing monetary value. The current study validates a laboratory choice procedure for studying smoking in adolescents, and demonstrates that adolescent smoking behavior is sensitive to changes in the magnitude of concurrently available monetary reinforcers. The current paradigm can be adapted and applied to explore the effects of other variables that may affect cigarette choice in adolescents. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Accounting for costs, QALYs, and capacity constraints: using discrete-event simulation to evaluate alternative service delivery and organizational scenarios for hospital-based glaucoma services.

PubMed

Crane, Glenis J; Kymes, Steven M; Hiller, Janet E; Casson, Robert; Martin, Adam; Karnon, Jonathan D

2013-11-01

Decision-analytic models are routinely used as a framework for cost-effectiveness analyses of health care services and technologies; however, these models mostly ignore resource constraints. In this study, we use a discrete-event simulation model to inform a cost-effectiveness analysis of alternative options for the organization and delivery of clinical services in the ophthalmology department of a public hospital. The model is novel, given that it represents both disease outcomes and resource constraints in a routine clinical setting. A 5-year discrete-event simulation model representing glaucoma patient services at the Royal Adelaide Hospital (RAH) was implemented and calibrated to patient-level data. The data were sourced from routinely collected waiting and appointment lists, patient record data, and the published literature. Patient-level costs and quality-adjusted life years were estimated for a range of alternative scenarios, including combinations of alternate follow-up times, booking cycles, and treatment pathways. The model shows that a) extending booking cycle length from 4 to 6 months, b) extending follow-up visit times by 2 to 3 months, and c) using laser in preference to medication are more cost-effective than current practice at the RAH eye clinic. The current simulation model provides a useful tool for informing improvements in the organization and delivery of glaucoma services at a local level (e.g., within a hospital), on the basis of expected effects on costs and health outcomes while accounting for current capacity constraints. Our model may be adapted to represent glaucoma services at other hospitals, whereas the general modeling approach could be applied to many other clinical service areas.

[Issues of biomedical support of explorations missions].

PubMed

Potapov, A N; Sinyak, Yu E; Petrov, V M

2013-01-01

Sine qua non for piloted exploration missions is a system of biomedical support. The future system will be considerably different from the analogous systems applied in current orbital missions. The reason is the challenging conditions in expeditions to remote space. In a mission to Mars, specifically, these are high levels of radiation, hypomagnetic environment, alternation of micro- and hypogravity, very long mission duration and autonomy. The paper scrutinizes the major issues of medical support to future explorers of space.

Center of Excellence for Applied Mathematical and Statistical Research in support of development of multicrop production monitoring capability

NASA Technical Reports Server (NTRS)

Woodward, W. A.; Gray, H. L.

1983-01-01

Efforts in support of the development of multicrop production monitoring capability are reported. In particular, segment level proportion estimation techniques based upon a mixture model were investigated. Efforts have dealt primarily with evaluation of current techniques and development of alternative ones. A comparison of techniques is provided on both simulated and LANDSAT data along with an analysis of the quality of profile variables obtained from LANDSAT data.

Silviculture for a declining species, Cerulean Warbler: 10-year results of a pilot study in the Mississippi Alluvial Valley

Treesearch

Paul B. Hamel; Mike Staten; Ray Souter; Carl G. Smith III; Gene Holland

2016-01-01

We report on the current status of a long-term study of Cerulean Warbler (Setophaga cerulea) response to silviculture on a 58-ha tract in Desha County, Arkansas. The work involved a 10 year premanipulation monitoring of the birds on the tract, followed by implementation of a split plot comparison of alternative treatments, each applied to a randomly selected half of...

TT-C-490 -Implementing Alternatives Through Specifications (Briefing Charts)

DTIC Science & Technology

2014-11-18

currently valid OMB control number. 1. REPORT DATE 18 NOV 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE TT-C...Existing Pretreatments for CARC Coating System TT-C-490E – Pretreatments specific for ferrous substrates – Specifies either zinc phosphate conversion...Only pretreatment allowed for multi- metal application – Zinc phosphate is either applied by immersion or spray in a contained area Prior to 2013

Aligning fast alternating current electroosmotic flow fields and characteristic frequencies with dielectrophoretic traps to achieve rapid bacteria detection.

PubMed

Gagnon, Zachary; Chang, Hsueh-Chia

2005-10-01

Tailor-designed alternating current electroosmotic (AC-EO) stagnation flows are used to convect bioparticles globally from a bulk solution to localized dielectrophoretic (DEP) traps that are aligned at the flow stagnation points. The multiscale trap, with a typical trapping time of seconds for a dilute 70 microL volume of 10(3) particles per cc sample, is several orders of magnitude faster than conventional DEP traps and earlier AC-EO traps with parallel, castellated, or finger electrodes. A novel serpentine wire capable of sustaining a high voltage, up to 2500 V(RMS), without causing excessive heat dissipation or Faradaic reaction in strong electrolytes is fabricated to produce the strong AC-EO flow with two separated stagnation lines, one aligned with the field minimum and one with the field maximum. The continuous wire design allows a large applied voltage without inducing Faradaic electrode reactions. Particles are trapped within seconds at one of the traps depending on whether they suffer negative or positive DEP. The particles can also be rapidly released from their respective traps by varying the frequency of the applied AC field below particle-distinct cross-over frequencies. Zwitterion addition to the buffer allows further geometric and frequency alignments of the AC-EO and DEP motions. The same device hence allows fast trapping, detection, sorting, and characterization on a sample with realistic conductivity, volume, and bacteria count.

Simulation and Fabrication of Wagon-Wheel-Shaped Piezoelectric Transducer for Raindrop Energy Harvesting Application

NASA Astrophysics Data System (ADS)

Wong, Chin Hong; Dahari, Zuraini; Jumali, Mohammad Hafizuddin; Mohamed, Khairudin; Mohamed, Julie Juliewatty

2017-03-01

Harvesting vibrational energy from impacting raindrops using piezoelectric material has been proven to be a promising approach for future outdoor applications, providing a good alternative resource that can be applied in outdoor rainy environments. We present herein an optimum novel polyvinylidene fluoride (PVDF) piezoelectric transducer specifically developed to harvest raindrop energy. The finite-element method was applied for simulation and optimization of the piezoelectric raindrop energy harvester (PREH) using COMSOL Multiphysics software, investigating the electrical potential, surface charge density, and total displacement for different transducer dimensions. According to the simulation results, the structure that generated the highest electrical potential and surface charge density was a wagon-wheel-shaped structure consisting of six spokes with wheel diameter of 30 mm, spoke width of 2 mm, center pad diameter of 6 mm, and thickness of 25 μm. This optimum wagon-wheel-shaped device was then fabricated by spin coating of PVDF, sputtering of aluminum, a poling process, and computer numerical control machining of a polytetrafluoroethylene stand. The fabricated PREH was characterized by x-ray diffraction analysis and Fourier-transform infrared spectroscopy. Finally, the fabricated PREH was tested under actual rain conditions with an alternating current to direct current converter connected in parallel, revealing that a single cell could generate average peak voltage of 22.5 mV and produce electrical energy of 3.4 nJ from ten impacts in 20 s.

Combining molecular dynamics and an electrodiffusion model to calculate ion channel conductance

NASA Astrophysics Data System (ADS)

Wilson, Michael A.; Nguyen, Thuy Hien; Pohorille, Andrew

2014-12-01

Establishing the relation between the structures and functions of protein ion channels, which are protein assemblies that facilitate transmembrane ion transport through water-filled pores, is at the forefront of biological and medical sciences. A reliable way to determine whether our understanding of this relation is satisfactory is to reproduce the measured ionic conductance over a broad range of applied voltages. This can be done in molecular dynamics simulations by way of applying an external electric field to the system and counting the number of ions that traverse the channel per unit time. Since this approach is computationally very expensive we develop a markedly more efficient alternative in which molecular dynamics is combined with an electrodiffusion equation. This alternative approach applies if steady-state ion transport through channels can be described with sufficient accuracy by the one-dimensional diffusion equation in the potential given by the free energy profile and applied voltage. The theory refers only to line densities of ions in the channel and, therefore, avoids ambiguities related to determining the surface area of the channel near its endpoints or other procedures connecting the line and bulk ion densities. We apply the theory to a simple, model system based on the trichotoxin channel. We test the assumptions of the electrodiffusion equation, and determine the precision and consistency of the calculated conductance. We demonstrate that it is possible to calculate current/voltage dependence and accurately reconstruct the underlying (equilibrium) free energy profile, all from molecular dynamics simulations at a single voltage. The approach developed here applies to other channels that satisfy the conditions of the electrodiffusion equation.

Generalization of the Child-Langmuir law to the alternate extraction of positive and negative ions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lafleur, T., E-mail: trevor.lafleur@lpp.polytechnique.fr; ONERA-The French Aerospace Lab, 91120 Palaiseau; Aanesland, A.

Using a combined analytical and simulation approach, we investigate positive and negative ion extraction between two electrodes from an ion-ion plasma source. With a square voltage waveform applied to the electrodes, we obtain approximate analytical solutions for the time-averaged extracted current densities, which are given simply by: J{sub p}{sup ac}=[α−fL√((M{sub p})/(q{sub p}V{sub 0}) )]J{sub p}{sup dc}, and J{sub n}{sup ac}=[(1−α)−fL√((M{sub n})/(q{sub n}V{sub 0}) )]J{sub n}{sup dc}, where J{sup ac} is the time-averaged current density, α is the square waveform duty cycle, f is the frequency, L is the electrode gap length, M is the ion mass, q is the ionmore » charge, V{sub 0} is the applied voltage amplitude, J{sup dc} is the dc extracted current density, and the subscripts p and n refer to positive and negative ions, respectively. In particular, if J{sup dc} is the dc space-charge limited current density, then these equations describe the square waveform generalization of the Child-Langmuir law.« less

Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing.

PubMed

Huertas, César S; Carrascosa, L G; Bonnal, S; Valcárcel, J; Lechuga, L M

2016-04-15

Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. Its deregulation is strongly linked to disease onset and progression. Current methodologies for monitoring alternative splicing demand elaborate procedures and often present difficulties in discerning between closely related isoforms, e.g. due to cross-hybridization during their detection. Herein, we report a general methodology using a Surface Plasmon Resonance (SPR) biosensor for label-free monitoring of alternative splicing events in real-time, without any cDNA synthesis or PCR amplification requirements. We applied this methodology to RNA isolated from HeLa cells for the quantification of alternatively spliced isoforms of the Fas gene, involved in cancer progression through regulation of programmed cell death. We demonstrate that our methodology is isoform-specific, with virtually no cross-hybridization, achieving limits of detection (LODs) in the picoMolar (pM) range. Similar results were obtained for the detection of the BCL-X gene mRNA isoforms. The results were independently validated by RT-qPCR, with excellent concordance in the determination of isoform ratios. The simplicity and robustness of this biosensor technology can greatly facilitate the exploration of alternative splicing biomarkers in disease diagnosis and therapy. Copyright © 2015 Elsevier B.V. All rights reserved.

A Community Standard: Equivalency of Healthcare in Australian Immigration Detention.

PubMed

Essex, Ryan

2017-08-01

The Australian government has long maintained that the standard of healthcare provided in its immigration detention centres is broadly comparable with health services available within the Australian community. Drawing on the literature from prison healthcare, this article examines (1) whether the principle of equivalency is being applied in Australian immigration detention and (2) whether this standard of care is achievable given Australia's current policies. This article argues that the principle of equivalency is not being applied and that this standard of health and healthcare will remain unachievable in Australian immigration detention without significant reform. Alternate approaches to addressing the well documented issues related to health and healthcare in Australian immigration detention are discussed.

46 CFR 111.05-27 - Grounded neutral alternating current systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the ground connection, is able to withstand the maximum available fault current without damage, and... 46 Shipping 4 2011-10-01 2011-10-01 false Grounded neutral alternating current systems. 111.05-27... Grounded neutral alternating current systems. Grounded neutral and high-impedance grounded neutral...

46 CFR 111.05-27 - Grounded neutral alternating current systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the ground connection, is able to withstand the maximum available fault current without damage, and... 46 Shipping 4 2010-10-01 2010-10-01 false Grounded neutral alternating current systems. 111.05-27... Grounded neutral alternating current systems. Grounded neutral and high-impedance grounded neutral...

The study of surface wetting, nanobubbles and boundary slip with an applied voltage: A review

PubMed Central

Pan, Yunlu; Zhao, Xuezeng

2014-01-01

Summary The drag of fluid flow at the solid–liquid interface in the micro/nanoscale is an important issue in micro/nanofluidic systems. Drag depends on the surface wetting, nanobubbles, surface charge and boundary slip. Some researchers have focused on the relationship between these interface properties. In this review, the influence of an applied voltage on the surface wettability, nanobubbles, surface charge density and slip length are discussed. The contact angle (CA) and contact angle hysteresis (CAH) of a droplet of deionized (DI) water on a hydrophobic polystyrene (PS) surface were measured with applied direct current (DC) and alternating current (AC) voltages. The nanobubbles in DI water and three kinds of saline solution on a PS surface were imaged when a voltage was applied. The influence of the surface charge density on the nanobubbles was analyzed. Then the slip length and the electrostatic force on the probe were measured on an octadecyltrichlorosilane (OTS) surface with applied voltage. The influence of the surface charge on the boundary slip and drag of fluid flow has been discussed. Finally, the influence of the applied voltage on the surface wetting, nanobubbles, surface charge, boundary slip and the drag of liquid flow are summarized. With a smaller surface charge density which could be achieved by applying a voltage on the surface, larger and fewer nanobubbles, a larger slip length and a smaller drag of liquid flow could be found. PMID:25161839

The study of surface wetting, nanobubbles and boundary slip with an applied voltage: A review.

PubMed

Pan, Yunlu; Bhushan, Bharat; Zhao, Xuezeng

2014-01-01

The drag of fluid flow at the solid-liquid interface in the micro/nanoscale is an important issue in micro/nanofluidic systems. Drag depends on the surface wetting, nanobubbles, surface charge and boundary slip. Some researchers have focused on the relationship between these interface properties. In this review, the influence of an applied voltage on the surface wettability, nanobubbles, surface charge density and slip length are discussed. The contact angle (CA) and contact angle hysteresis (CAH) of a droplet of deionized (DI) water on a hydrophobic polystyrene (PS) surface were measured with applied direct current (DC) and alternating current (AC) voltages. The nanobubbles in DI water and three kinds of saline solution on a PS surface were imaged when a voltage was applied. The influence of the surface charge density on the nanobubbles was analyzed. Then the slip length and the electrostatic force on the probe were measured on an octadecyltrichlorosilane (OTS) surface with applied voltage. The influence of the surface charge on the boundary slip and drag of fluid flow has been discussed. Finally, the influence of the applied voltage on the surface wetting, nanobubbles, surface charge, boundary slip and the drag of liquid flow are summarized. With a smaller surface charge density which could be achieved by applying a voltage on the surface, larger and fewer nanobubbles, a larger slip length and a smaller drag of liquid flow could be found.

Transcranial electrical stimulation over visual cortex evokes phosphenes with a retinal origin.

PubMed

Kar, Kohitij; Krekelberg, Bart

2012-10-01

Transcranial electrical stimulation (tES) is a promising therapeutic tool for a range of neurological diseases. Understanding how the small currents used in tES spread across the scalp and penetrate the brain will be important for the rational design of tES therapies. Alternating currents applied transcranially above visual cortex induce the perception of flashes of light (phosphenes). This makes the visual system a useful model to study tES. One hypothesis is that tES generates phosphenes by direct stimulation of the cortex underneath the transcranial electrode. Here, we provide evidence for the alternative hypothesis that phosphenes are generated in the retina by current spread from the occipital electrode. Building on the existing literature, we first confirm that phosphenes are induced at lower currents when electrodes are placed farther away from visual cortex and closer to the eye. Second, we explain the temporal frequency tuning of phosphenes based on the well-known response properties of primate retinal ganglion cells. Third, we show that there is no difference in the time it takes to evoke phosphenes in the retina or by stimulation above visual cortex. Together, these findings suggest that phosphenes induced by tES over visual cortex originate in the retina. From this, we infer that tES currents spread well beyond the area of stimulation and are unlikely to lead to focal neural activation. Novel stimulation protocols that optimize current distributions are needed to overcome these limitations of tES.

Advanced Controller Developed for the Free-Piston Stirling Convertor

NASA Technical Reports Server (NTRS)

Gerber, Scott S.

2005-01-01

A free-piston Stirling power convertor is being considered as an advanced power-conversion technology for future NASA deep-space missions requiring long-life radioisotope power systems. The NASA Glenn Research Center has identified key areas where advanced technologies can enhance the capability of Stirling energy-conversion systems. One of these is power electronic controls. Current power-conversion technology for Glenn-tested Stirling systems consists of an engine-driven linear alternator generating an alternating-current voltage controlled by a tuning-capacitor-based alternating-current peak voltage load controller. The tuning capacitor keeps the internal alternator electromotive force (EMF) in phase with its respective current (i.e., passive power factor correction). The alternator EMF is related to the piston velocity, which must be kept in phase with the alternator current in order to achieve stable operation. This tuning capacitor, which adds volume and mass to the overall Stirling convertor, can be eliminated if the controller can actively drive the magnitude and phase of the alternator current.

Global fishery prospects under contrasting management regimes.

PubMed

Costello, Christopher; Ovando, Daniel; Clavelle, Tyler; Strauss, C Kent; Hilborn, Ray; Melnychuk, Michael C; Branch, Trevor A; Gaines, Steven D; Szuwalski, Cody S; Cabral, Reniel B; Rader, Douglas N; Leland, Amanda

2016-05-03

Data from 4,713 fisheries worldwide, representing 78% of global reported fish catch, are analyzed to estimate the status, trends, and benefits of alternative approaches to recovering depleted fisheries. For each fishery, we estimate current biological status and forecast the impacts of contrasting management regimes on catch, profit, and biomass of fish in the sea. We estimate unique recovery targets and trajectories for each fishery, calculate the year-by-year effects of alternative recovery approaches, and model how alternative institutional reforms affect recovery outcomes. Current status is highly heterogeneous-the median fishery is in poor health (overfished, with further overfishing occurring), although 32% of fisheries are in good biological, although not necessarily economic, condition. Our business-as-usual scenario projects further divergence and continued collapse for many of the world's fisheries. Applying sound management reforms to global fisheries in our dataset could generate annual increases exceeding 16 million metric tons (MMT) in catch, $53 billion in profit, and 619 MMT in biomass relative to business as usual. We also find that, with appropriate reforms, recovery can happen quickly, with the median fishery taking under 10 y to reach recovery targets. Our results show that commonsense reforms to fishery management would dramatically improve overall fish abundance while increasing food security and profits.

Global fishery prospects under contrasting management regimes

PubMed Central

Costello, Christopher; Ovando, Daniel; Clavelle, Tyler; Strauss, C. Kent; Hilborn, Ray; Melnychuk, Michael C.; Branch, Trevor A.; Gaines, Steven D.; Szuwalski, Cody S.; Cabral, Reniel B.; Rader, Douglas N.; Leland, Amanda

2016-01-01

Data from 4,713 fisheries worldwide, representing 78% of global reported fish catch, are analyzed to estimate the status, trends, and benefits of alternative approaches to recovering depleted fisheries. For each fishery, we estimate current biological status and forecast the impacts of contrasting management regimes on catch, profit, and biomass of fish in the sea. We estimate unique recovery targets and trajectories for each fishery, calculate the year-by-year effects of alternative recovery approaches, and model how alternative institutional reforms affect recovery outcomes. Current status is highly heterogeneous—the median fishery is in poor health (overfished, with further overfishing occurring), although 32% of fisheries are in good biological, although not necessarily economic, condition. Our business-as-usual scenario projects further divergence and continued collapse for many of the world’s fisheries. Applying sound management reforms to global fisheries in our dataset could generate annual increases exceeding 16 million metric tons (MMT) in catch, $53 billion in profit, and 619 MMT in biomass relative to business as usual. We also find that, with appropriate reforms, recovery can happen quickly, with the median fishery taking under 10 y to reach recovery targets. Our results show that commonsense reforms to fishery management would dramatically improve overall fish abundance while increasing food security and profits. PMID:27035953

Food applications of natural antimicrobial compounds.

PubMed

Lucera, Annalisa; Costa, Cristina; Conte, Amalia; Del Nobile, Matteo A

2012-01-01

In agreement with the current trend of giving value to natural and renewable resources, the use of natural antimicrobial compounds, particularly in food and biomedical applications, becomes very frequent. The direct addition of natural compounds to food is the most common method of application, even if numerous efforts have been made to find alternative solutions to the aim of avoiding undesirable inactivation. Dipping, spraying, and coating treatment of food with active solutions are currently applied to product prior to packaging as valid options. The aim of the current work is to give an overview on the use of natural compounds in food sector. In particular, the review will gather numerous case-studies of meat, fish, dairy products, minimally processed fruit and vegetables, and cereal-based products where these compounds found application.

Food applications of natural antimicrobial compounds

PubMed Central

Lucera, Annalisa; Costa, Cristina; Conte, Amalia; Del Nobile, Matteo A.

2012-01-01

In agreement with the current trend of giving value to natural and renewable resources, the use of natural antimicrobial compounds, particularly in food and biomedical applications, becomes very frequent. The direct addition of natural compounds to food is the most common method of application, even if numerous efforts have been made to find alternative solutions to the aim of avoiding undesirable inactivation. Dipping, spraying, and coating treatment of food with active solutions are currently applied to product prior to packaging as valid options. The aim of the current work is to give an overview on the use of natural compounds in food sector. In particular, the review will gather numerous case-studies of meat, fish, dairy products, minimally processed fruit and vegetables, and cereal-based products where these compounds found application. PMID:23060862

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liun, Edwaren, E-mail: edwaren@batan.go.id; Suparman, E-mail: edwaren@batan.go.id

Regarding nuclear power plant development in Bangka Island, it can be estimated that produced power will be oversupply for the Bangka Island and needs to transmit to Sumatra or Java Island. The distance between the regions or islands causing considerable loss of power in transmission by alternating current, and a wide range of technical and economical issues. The objective of this paper addresses to economics analysis of direct current transmission system to overcome those technical problem. Direct current transmission has a stable characteristic, so that the power delivery from Bangka to Sumatra or Java in a large scale efficiently andmore » reliably can be done. HVDC system costs depend on the power capacity applied to the system and length of the transmission line in addition to other variables that may be different.« less

Cost estimation of HVDC transmission system of Bangka's NPP candidates

NASA Astrophysics Data System (ADS)

Liun, Edwaren; Suparman

2014-09-01

Regarding nuclear power plant development in Bangka Island, it can be estimated that produced power will be oversupply for the Bangka Island and needs to transmit to Sumatra or Java Island. The distance between the regions or islands causing considerable loss of power in transmission by alternating current, and a wide range of technical and economical issues. The objective of this paper addresses to economics analysis of direct current transmission system to overcome those technical problem. Direct current transmission has a stable characteristic, so that the power delivery from Bangka to Sumatra or Java in a large scale efficiently and reliably can be done. HVDC system costs depend on the power capacity applied to the system and length of the transmission line in addition to other variables that may be different.

Causal Models for Mediation Analysis: An Introduction to Structural Mean Models.

PubMed

Zheng, Cheng; Atkins, David C; Zhou, Xiao-Hua; Rhew, Isaac C

2015-01-01

Mediation analyses are critical to understanding why behavioral interventions work. To yield a causal interpretation, common mediation approaches must make an assumption of "sequential ignorability." The current article describes an alternative approach to causal mediation called structural mean models (SMMs). A specific SMM called a rank-preserving model (RPM) is introduced in the context of an applied example. Particular attention is given to the assumptions of both approaches to mediation. Applying both mediation approaches to the college student drinking data yield notable differences in the magnitude of effects. Simulated examples reveal instances in which the traditional approach can yield strongly biased results, whereas the RPM approach remains unbiased in these cases. At the same time, the RPM approach has its own assumptions that must be met for correct inference, such as the existence of a covariate that strongly moderates the effect of the intervention on the mediator and no unmeasured confounders that also serve as a moderator of the effect of the intervention or the mediator on the outcome. The RPM approach to mediation offers an alternative way to perform mediation analysis when there may be unmeasured confounders.

An approach for the anticipatory and participatory management of current and future flood risks

NASA Astrophysics Data System (ADS)

Luther, J.

2012-04-01

Despite the fact that many measures to attenuate flood hazards and reduce vulnerabilities are being implemented, adverse effects of floods are ever-increasing in most parts of the world. On the one hand this holds true for economically and/or demographically growing regions. On the other hand this applies also to areas that face population shrinkage and economic problems. Such flood risks occur in human-environment systems and are subject to dynamics caused by a number of drivers such as climate change, land-use changes, and others. Many drivers evolve slowly over time or show time-lag effects and long return periods. Moreover, certain decisions may determine the control actions of the following decades. At present, current flood risks are mostly determined based on historic developments and the ex post analysis of flood events. Approaches that look at the future dynamics of both hazards and vulnerable elements ex ante in an integrated manner are rare. Instead, future hazard scenarios are often just overlaid with current socio-economic data, which poses a strong inconsistency. Usually the focus lies on rather short-term, specific or local problems. But many developments and measures show their effects only after long time periods and when considering the whole catchment area. This calls for a holistic and long-term view into the future and implies the challenge of dealing with many uncertainties due to the system's complexity. In order to anticipate and react to these developments, this contribution suggests developing a flexible, yet holistic approach to design, analyse and evaluate alternative futures of such human-environment systems. These futures follow a scenario understanding that considers both specific (current) factor constellations as well as consistent assumptions on autonomous developments (so-called development frameworks) and potentials for control (strategic alternatives) of the interacting entities that influence flood risk. Different scenario concepts and the application of respective techniques are thus reviewed and incorporated with regard to their suitability for an integrated management of current and future flood risks. In particular, "hybrid scenarios" with qualitative and quantitative components represented by nested models as well as assumptions across different spatiotemporal scales, respectively, are suggested for dealing with the uncertainties when assessing flood risks throughout a system's possible evolution. The (initially top-down developed) approach and its components will be briefly presented. These "scenario products" could later serve as a stimulus for discussions that bring together different actors and enhance - and eventually legitimise - the scenarios further in a "scenario process": (1) A first step is the conceptualisation of a flood risk system following the SPRC-model. Its physical geographical and anthropogenic factors may either be subject to autonomous trends, target-oriented control, or facultative system behaviour (e.g. dike breaches). With this concept, the integration of different processes and scales is aspired. (2) Secondly, it is conceptually shown how the risk cascade for present and future states of the flood risk system can be calculated based on coupled models ranging from climate change projections to a damage simulation models. (3) Thirdly, ways to develop socioeconomic storylines for the development frameworks and guiding principles for the strategic alternatives are presented and the futures are combined. This involves making plausible and consistent assumptions for many system factors and their drivers and finding ways to harmonise existing data for the same areas and time steps. (4) Fourthly, selected futures can be analysed and evaluated ex ante applying the coupled models of the second step to derive the emerging flood risks. The evaluation addresses, amongst other aspects, the identification of (i) the sensitivity of all scenarios against the current strategic alternative; (ii) the resulting risks when applying different strategic alternatives against one selected scenario; (iii) the efficiency (as cost-effectiveness) and robustness of one selected strategic alternative against the different scenarios; and (iv) the model uncertainty, for example caused by different climate downscaling methods. It is of growing importance to place any scenario/simulation results in a societal or even individual context and confront them with the perspectives of the people potentially affected. Only this yields a holistic picture and may lead to sustainable, comprehensible decisions. The approach is partly exemplified with research conducted in Saxony (Germany) and the Elbe River catchment in Central Europe and concentrates on river or plain floods, neglecting water quality issues.

Flood Hazard Mapping by Applying Fuzzy TOPSIS Method

NASA Astrophysics Data System (ADS)

Han, K. Y.; Lee, J. Y.; Keum, H.; Kim, B. J.; Kim, T. H.

2017-12-01

There are lots of technical methods to integrate various factors for flood hazard mapping. The purpose of this study is to suggest the methodology of integrated flood hazard mapping using MCDM(Multi Criteria Decision Making). MCDM problems involve a set of alternatives that are evaluated on the basis of conflicting and incommensurate criteria. In this study, to apply MCDM to assessing flood risk, maximum flood depth, maximum velocity, and maximum travel time are considered as criterion, and each applied elements are considered as alternatives. The scheme to find the efficient alternative closest to a ideal value is appropriate way to assess flood risk of a lot of element units(alternatives) based on various flood indices. Therefore, TOPSIS which is most commonly used MCDM scheme is adopted to create flood hazard map. The indices for flood hazard mapping(maximum flood depth, maximum velocity, and maximum travel time) have uncertainty concerning simulation results due to various values according to flood scenario and topographical condition. These kind of ambiguity of indices can cause uncertainty of flood hazard map. To consider ambiguity and uncertainty of criterion, fuzzy logic is introduced which is able to handle ambiguous expression. In this paper, we made Flood Hazard Map according to levee breach overflow using the Fuzzy TOPSIS Technique. We confirmed the areas where the highest grade of hazard was recorded through the drawn-up integrated flood hazard map, and then produced flood hazard map can be compared them with those indicated in the existing flood risk maps. Also, we expect that if we can apply the flood hazard map methodology suggested in this paper even to manufacturing the current flood risk maps, we will be able to make a new flood hazard map to even consider the priorities for hazard areas, including more varied and important information than ever before. Keywords : Flood hazard map; levee break analysis; 2D analysis; MCDM; Fuzzy TOPSIS Acknowlegement This research was supported by a grant (17AWMP-B079625-04) from Water Management Research Program funded by Ministry of Land, Infrastructure and Transport of Korean government.

Multisource energy system project

NASA Astrophysics Data System (ADS)

Dawson, R. W.; Cowan, R. A.

1987-03-01

The mission of this project is to investigate methods of providing uninterruptible power to Army communications and navigational facilities, many of which have limited access or are located in rugged terrain. Two alternatives are currently available for deploying terrestrial stand-alone power systems: (1) conventional electric systems powered by diesel fuel, propane, or natural gas, and (2) alternative power systems using renewable energy sources such as solar photovoltaics (PV) or wind turbines (WT). The increased cost of fuels for conventional systems and the high cost of energy storage for single-source renewable energy systems have created interest in the hybrid or multisource energy system. This report will provide a summary of the first and second interim reports, final test results, and a user's guide for software that will assist in applying and designing multi-source energy systems.

Chasing down the triple-negative myeloproliferative neoplasms: Implications for molecular diagnostics.

PubMed

Langabeer, Stephen E

2016-01-01

The majority of patients with classical myeloproliferative neoplasms (MPN) of polycythemia vera, essential thrombocythemia, and primary myelofibrosis harbor distinct disease-driving mutations within the JAK2 , CALR , or MPL genes. The term triple-negative has been recently applied to those MPN without evidence of these consistent mutations, prompting whole or targeted exome sequencing approaches to determine the driver mutational status of this subgroup. These strategies have identified numerous novel mutations that occur in alternative exons of both JAK2 and MPL , the majority of which result in functional activation. Current molecular diagnostic approaches may possess insufficient coverage to detect these alternative mutations, prompting further consideration of targeted exon sequencing into routine diagnostic practice. How to incorporate these illuminating findings into the expanding molecular diagnostic algorithm for MPN requires continual attention.

Acceleration of short and long DNA read mapping without loss of accuracy using suffix array.

PubMed

Tárraga, Joaquín; Arnau, Vicente; Martínez, Héctor; Moreno, Raul; Cazorla, Diego; Salavert-Torres, José; Blanquer-Espert, Ignacio; Dopazo, Joaquín; Medina, Ignacio

2014-12-01

HPG Aligner applies suffix arrays for DNA read mapping. This implementation produces a highly sensitive and extremely fast mapping of DNA reads that scales up almost linearly with read length. The approach presented here is faster (over 20× for long reads) and more sensitive (over 98% in a wide range of read lengths) than the current state-of-the-art mappers. HPG Aligner is not only an optimal alternative for current sequencers but also the only solution available to cope with longer reads and growing throughputs produced by forthcoming sequencing technologies. https://github.com/opencb/hpg-aligner. © The Author 2014. Published by Oxford University Press.

A spin current rectifier

NASA Astrophysics Data System (ADS)

Eyni, Zahra; Mohammadpour, Hakimeh

2017-12-01

Current modulation and rectification is an important subject of electronics as well as spintronics. In this paper, an efficient rectifying mesoscopic device is introduced. The device is a two terminal device on the 2D plane of electron gas. The lateral contacts are half-metal ferromagnetic with antiparallel magnetizations and the central channel region is taken as ferromagnetic or normal in the presence of an applied magnetic field. The device functionality is based on the modification of spin-current by tuning the strength of the magnetic field or equivalently by the exchange coupling of the channel to the substrate. The result is that the (spin-) current depends on the polarity of the bias voltage. Converting an alternating bias voltage to direct current is the main achievement of this model device with an additional profit of rectified spin-current. We analyze the results in terms of the spin-dependent barrier in the channel. Detecting the strength of the magnetic field by spin polarization is also suggested.

Electroosmotic flow in microchannels with arbitrary geometry and arbitrary distribution of wall charge.

PubMed

Xuan, Xiangchun; Li, Dongqing

2005-09-01

General solutions are developed for direct current (DC) and alternating current (AC) electroosmotic flows in microfluidic channels with arbitrary cross-sectional geometry and arbitrary distribution of wall charge (zeta potential). The applied AC electric field can also be of arbitrary waveform. By proposing a nondimensional time scale varpi defined as the ratio of the diffusion time of momentum across the electric double-layer thickness to the period of the applied electric field, we demonstrate analytically that the Helmholtz-Smoluchowski electroosmotic velocity is an appropriate slip condition for AC electroosmotic flows in typical microfluidic applications. With this slip condition approach, electroosmotic flows in rectangular and asymmetric trapezoidal microchannels with nonuniform wall charge, as examples, are investigated. The unknown constants in the proposed general solutions are numerically determined with a least-squares method through matching the boundary conditions. We find that the wall charge affects significantly the electroosmotic flow while the channel geometry does not. Moreover, the flow feature is characterized by another nondimensional time scale Omega defined as the ratio of the diffusion time of momentum across the channel hydraulic radius to the period of the applied electric field. The onset of phase shift between AC electroosmotic velocity and applied electric field is also examined analytically.

Male Partners' Investment and Alternatives as Correlates of Women's Coerced First Sexual Intercourse in Chinese Dating Relationships: A Social Exchange Perspective.

PubMed

He, Shanshan; Tsang, Sandra

2016-10-01

Social exchange theory has great potential to help our understanding of dating partners' sexual interaction. Yet, to our knowledge, there is still no empirical study applying this theory to explain sexual coercion in the context of intimate relationships. This study examined the relationship between male partners' social exchange variables (investment and alternatives) and women's coerced first sexual intercourse in dating relationships, within both gender samples (not dyadic data). A total of 927 valid questionnaires were collected by purposive snowball sampling in five main cities in China of college students who were currently in a romantic relationship. Results showed that in the male sample, male partners' investment significantly and positively correlated with emotional manipulation coercive tactics, and their alternatives significantly and positively predicted defection threats as coercive tactics. In the female sample, there were no such observations. The research hypotheses of this study have been partially supported, and its implications and limitations are discussed.

Magnetic nanotubes for drug delivery

NASA Astrophysics Data System (ADS)

Ramasamy, Mouli; Kumar, Prashanth S.; Varadan, Vijay K.

2017-04-01

Magnetic nanotubes hold the potential for neuroscience applications because of their capability to deliver chemicals or biomolecules and the feasibility of controlling the orientation or movement of these magnetic nanotubes by an external magnetic field thus facilitating directed growth of neurites. Therefore, we sought to investigate the effects of laminin treated magnetic nanotubes and external alternating magnetic fields on the growth of dorsal root ganglion (DRG) neurons in cell culture. Magnetic nanotubes were synthesized by a hydrothermal method and characterized to confirm their hollow structure, the hematite and maghemite phases, and the magnetic properties. DRG neurons were cultured in the presence of magnetic nanotubes under alternating magnetic fields. Electron microscopy showed a close interaction between magnetic nanotubes and the growing neurites Phase contrast microscopy revealed live growing neurons suggesting that the combination of the presence of magnetic nanotubes and the alternating magnetic field were tolerated by DRG neurons. The synergistic effect, from both laminin treated magnetic nanotubes and the applied magnetic fields on survival, growth and electrical activity of the DRG neurons are currently being investigated.

Electromagnetic acoustic transducer

DOEpatents

Alers, George A.; Burns, Jr., Leigh R.; MacLauchlan, Daniel T.

1988-01-01

A noncontact ultrasonic transducer for studying the acoustic properties of a metal workpiece includes a generally planar magnetizing coil positioned above the surface of the workpiece, and a generally planar eddy current coil between the magnetizing coil and the workpiece. When a large current is passed through the magnetizing coil, a large magnetic field is applied to the near-surface regions of the workpiece. The eddy current coil can then be operated as a transmitter by passing an alternating current therethrough to excite ultrasonic waves in the surface of the workpiece, or operated as a passive receiver to sense ultrasonic waves in the surface by measuring the output signal. The geometries of the two coils can be varied widely to be effective for different types of ultrasonic waves. The coils are preferably packaged in a housing which does not interfere with their operation, but protects them from a variety of adverse environmental conditions.

Laboratory animal science in China: current status and potential for adoption of Three R alternatives.

PubMed

Kong, Qi; Qin, Chuan

2010-03-01

This paper aims to describe the development of laboratory animal science in China on the basis of historical evidence and recent national survey data, and to identify the problems facing the adoption of Three R alternatives. The authors undertook a national survey in 2006, by means of a questionnaire sent to 31 provinces, municipalities and autonomous regions, and also compared data from a variety of sources, including several national surveys and published papers. Laboratory animal science in China has developed rapidly over the past 30 years, as a result of a combination of economic, governmental and societal forces. More than 100,000 people work in the field of laboratory animal science, in 2,000 laboratory animal centres, institutes, universities, organisations, and companies. During the year of our survey, more than 19 million laboratory animals were produced from 320 licensed production facilities. Approximately 16 million laboratory animals were used in animal experiments, in 1530 facilities licensed for their use. The scale of the market for the supply and use of laboratory animals is huge, and thus it is very important to improve the level of adoption of these alternatives, in education, research and testing. For China, this presents a significant economic and technological opportunity in the field of biosciences research. The concept of the Three Rs first appeared in China in the 1980s, when the scale of laboratory animal sciences was starting to increase. In the 1990s, the Three Rs concept became commonly accepted among laboratory animal scientists, and began to appear in government documents. In the first decade of the 21st century, the Three Rs principles have become increasingly applied in our day-to-day work. But further time is still needed to achieve the full application of the Three Rs principles, especially the adoption of Three R alternatives. This paper describes the achievements in China relating to laboratory animal science, the use of Three R alternatives, and animal welfare, and shows that there is currently great potential for the adoption of alternatives. The information will help scientists and organisations around the world to gain better insight into the current state of laboratory animal science in China, and hopefully, will enable them to give advice on how we can improve the adoption of Three R alternatives in our country. 2010 FRAME.

Meta-analysis of Odds Ratios: Current Good Practices

PubMed Central

Chang, Bei-Hung; Hoaglin, David C.

2016-01-01

Background Many systematic reviews of randomized clinical trials lead to meta-analyses of odds ratios. The customary methods of estimating an overall odds ratio involve weighted averages of the individual trials’ estimates of the logarithm of the odds ratio. That approach, however, has several shortcomings, arising from assumptions and approximations, that render the results unreliable. Although the problems have been documented in the literature for many years, the conventional methods persist in software and applications. A well-developed alternative approach avoids the approximations by working directly with the numbers of subjects and events in the arms of the individual trials. Objective We aim to raise awareness of methods that avoid the conventional approximations, can be applied with widely available software, and produce more-reliable results. Methods We summarize the fixed-effect and random-effects approaches to meta-analysis; describe conventional, approximate methods and alternative methods; apply the methods in a meta-analysis of 19 randomized trials of endoscopic sclerotherapy in patients with cirrhosis and esophagogastric varices; and compare the results. We demonstrate the use of SAS, Stata, and R software for the analysis. Results In the example, point estimates and confidence intervals for the overall log-odds-ratio differ between the conventional and alternative methods, in ways that can affect inferences. Programming is straightforward in the three software packages; an appendix gives the details. Conclusions The modest additional programming required should not be an obstacle to adoption of the alternative methods. Because their results are unreliable, use of the conventional methods for meta-analysis of odds ratios should be discontinued. PMID:28169977

Enhancing the sensitivity of mid-IR quantum cascade laser-based cavity-enhanced absorption spectroscopy using RF current perturbation.

PubMed

Manfred, Katherine M; Kirkbride, James M R; Ciaffoni, Luca; Peverall, Robert; Ritchie, Grant A D

2014-12-15

The sensitivity of mid-IR quantum cascade laser (QCL) off-axis cavity-enhanced absorption spectroscopy (CEAS), often limited by cavity mode structure and diffraction losses, was enhanced by applying a broadband RF noise to the laser current. A pump-probe measurement demonstrated that the addition of bandwidth-limited white noise effectively increased the laser linewidth, thereby reducing mode structure associated with CEAS. The broadband noise source offers a more sensitive, more robust alternative to applying single-frequency noise to the laser. Analysis of CEAS measurements of a CO(2) absorption feature at 1890  cm(-1) averaged over 100 ms yielded a minimum detectable absorption of 5.5×10(-3)  Hz(-1/2) in the presence of broadband RF perturbation, nearly a tenfold improvement over the unperturbed regime. The short acquisition time makes this technique suitable for breath applications requiring breath-by-breath gas concentration information.

BDD anodic treatment of 6:2 fluorotelomer sulfonate (6:2 FTSA). Evaluation of operating variables and by-product formation.

PubMed

Urtiaga, Ane; Soriano, Alvaro; Carrillo-Abad, Jordi

2018-06-01

The concerns about the undesired impacts on human health and the environment of long chain perfluorinated alkyl substances (PFASs) have driven industrial initiatives to replace PFASs by shorter chain fluorinated homologues. 6:2 fluorotelomer sulfonic acid (6:2 FTSA) is applied as alternative to PFOS in metal plating and fluoropolymer manufacture. This study reports the electrochemical treatment of aqueous 6:2 FTSA solutions on microcrystalline BDD anodes. Bench scale batch experiments were performed, focused on assessing the effect of the electrolyte and the applied current density (5-600 A m -2 ) on the removal of 6:2 FTSA, the reduction of total organic carbon (TOC) and the fluoride release. Results showed that at the low range of applied current density (J = 50 A m -2 ), using NaCl, Na 2 SO 4 and NaClO 4 , the electrolyte exerted a minimal effect on removal rates. The formation of toxic inorganic chlorine species such as ClO 4 - was not observed. When using Na 2 SO 4 electrolyte, increasing the applied current density to 350-600 A m -2 promoted a notable enhancement of the 6:2 FTSA removal and defluorination rates, pointing to the positive contribution of electrogenerated secondary oxidants to the overall removal rate. 6:2 FTSA was transformed into shorter-chain PFCAs, and eventually into CO 2 and fluoride, as TOC reduction was >90%. Finally, it was demonstrated that diffusion in the liquid phase was controlling the overall kinetic rate, although with moderate improvements due to secondary oxidants at very high current densities. Copyright © 2018 Elsevier Ltd. All rights reserved.

Differential effects of 10-Hz and 40-Hz transcranial alternating current stimulation (tACS) on endogenous versus exogenous attention.

PubMed

Hopfinger, Joseph B; Parsons, Jonathan; Fröhlich, Flavio

2017-04-01

Previous electrophysiological studies implicate both alpha (8-12 Hz) and gamma (>30 Hz) neural oscillations in the mechanisms of selective attention. Here, participants preformed two separate visual attention tasks, one endogenous and one exogenous, while transcranial alternating current stimulation (tACS), at 10 Hz, 40 Hz, or sham, was applied to the right parietal lobe. Our results provide new evidence for the roles of gamma and alpha oscillations in voluntary versus involuntary shifts of attention. Gamma (40 Hz) stimulation resulted in improved disengagement from invalidly cued targets in the endogenous attention task, whereas alpha stimulation (10 Hz) had no effect on endogenous attention, but increased the exogenous cuing effect. These findings agree with previous studies suggesting that right inferior parietal regions may be especially important for the disengagement of attention, and go further to provide details about the specific type of oscillatory neural activity within that brain region that is differentially involved in endogenous versus exogenous attention. Our results also have potential implications for the plasticity and training of attention systems.

Method to Eliminate Flux Linkage DC Component in Load Transformer for Static Transfer Switch

PubMed Central

2014-01-01

Many industrial and commercial sensitive loads are subject to the voltage sags and interruptions. The static transfer switch (STS) based on the thyristors is applied to improve the power quality and reliability. However, the transfer will result in severe inrush current in the load transformer, because of the DC component in the magnetic flux generated in the transfer process. The inrush current which is always 2~30 p.u. can cause the disoperation of relay protective devices and bring potential damage to the transformer. The way to eliminate the DC component is to transfer the related phases when the residual flux linkage of the load transformer and the prospective flux linkage of the alternate source are equal. This paper analyzes how the flux linkage of each winding in the load transformer changes in the transfer process. Based on the residual flux linkage when the preferred source is completely disconnected, the method to calculate the proper time point to close each phase of the alternate source is developed. Simulation and laboratory experiments results are presented to show the effectiveness of the transfer method. PMID:25133255

Method to eliminate flux linkage DC component in load transformer for static transfer switch.

PubMed

He, Yu; Mao, Chengxiong; Lu, Jiming; Wang, Dan; Tian, Bing

2014-01-01

Many industrial and commercial sensitive loads are subject to the voltage sags and interruptions. The static transfer switch (STS) based on the thyristors is applied to improve the power quality and reliability. However, the transfer will result in severe inrush current in the load transformer, because of the DC component in the magnetic flux generated in the transfer process. The inrush current which is always 2 ~ 30 p.u. can cause the disoperation of relay protective devices and bring potential damage to the transformer. The way to eliminate the DC component is to transfer the related phases when the residual flux linkage of the load transformer and the prospective flux linkage of the alternate source are equal. This paper analyzes how the flux linkage of each winding in the load transformer changes in the transfer process. Based on the residual flux linkage when the preferred source is completely disconnected, the method to calculate the proper time point to close each phase of the alternate source is developed. Simulation and laboratory experiments results are presented to show the effectiveness of the transfer method.

The Dynamics of Oblate Drop Between Heterogeneous Plates Under Alternating Electric Field. Non-uniform Field

NASA Astrophysics Data System (ADS)

Kashina, M. A.; Alabuzhev, A. A.

2018-02-01

The dynamics of the incompressible fluid drop under the non-uniform electric field are considered. The drop is bounded axially by two parallel solid planes and the case of heterogeneous plates is investigated. The external electric field acts as an external force that causes motion of the contact line. We assume that the electric current is alternative current and the AC filed amplitude is a spatially non-uniform function. In equilibrium, the drop has the form of a circular cylinder. The equilibrium contact angle is 0.5 π. In order to describe this contact line motion the modified Hocking boundary condition is applied: the velocity of the contact line is proportional to the deviation of the contact angle and the speed of the fast relaxation processes, which frequency is proportional to twice the frequency of the electric field. The Hocking parameter depends on the polar angle, i.e. the coefficient of the interaction between the plate and the fluid (the contact line) is a function of the plane coordinates. This function is expanded in a series of the Laplace operator eigenfunctions.

Quantitative study of electrophoretic and electroosmotic enhancement during alternating current iontophoresis across synthetic membranes.

PubMed

Yan, Guang; Li, S Kevin; Peck, Kendall D; Zhu, Honggang; Higuchi, William I

2004-12-01

One of the primary safety and tolerability limitations of direct current iontophoresis is the potential for electrochemical burns associated with the necessary current densities and/or application times required for effective treatment. Alternating current (AC) transdermal iontophoresis has the potential to eliminate electrochemical burns that are frequently observed during direct current transdermal iontophoresis. Although it has been demonstrated that the intrinsic permeability of skin can be increased by applying low-to-moderate AC voltages, transdermal transport phenomena and enhancement under AC conditions have not been systematically studied and are not well understood. The aim of the present work was to study the fundamental transport mechanisms of square-wave AC iontophoresis using a synthetic membrane system. The model synthetic membrane used was a composite Nuclepore membrane. AC frequencies ranging from 20 to 1000 Hz and AC fields ranging from 0.25 to 0.5 V/membrane were investigated. A charged permeant, tetraethyl ammonium, and a neutral permeant, arabinose, were used. The transport studies showed that flux was enhanced by increasing the AC voltage and decreasing AC frequency. Two theoretical transport models were developed: one is a homogeneous membrane model; the other is a heterogeneous membrane model. Experimental transport data were compared with computer simulations based on these models. Excellent agreement between model predictions and experimental data was observed when the data were compared with the simulations from the heterogeneous membrane model. (c) 2004 Wiley-Liss, Inc. and the American Pharmacists Association

46 CFR 111.30-25 - Alternating-current ship's service switchboards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Alternating-current ship's service switchboards. 111.30-25 Section 111.30-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Switchboards § 111.30-25 Alternating-current ship's service...

46 CFR 111.30-25 - Alternating-current ship's service switchboards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Alternating-current ship's service switchboards. 111.30-25 Section 111.30-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Switchboards § 111.30-25 Alternating-current ship's service...

46 CFR 111.30-25 - Alternating-current ship's service switchboards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Alternating-current ship's service switchboards. 111.30-25 Section 111.30-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Switchboards § 111.30-25 Alternating-current ship's service...

Analysis of hot forming of a sheet metal component made of advanced high strength steel

NASA Astrophysics Data System (ADS)

Demirkaya, Sinem; Darendeliler, Haluk; Gökler, Mustafa İlhan; Ayhaner, Murat

2013-05-01

To provide reduction in weight while maintaining crashworthiness and to decrease the fuel consumption of vehicles, thinner components made of Advanced High Strength Steels (AHSS) are being increasingly used in automotive industry. However, AHSS cannot be formed easily at the room temperature (i.e. cold forming). The alternative process involves heating, hot forming and subsequent quenching. A-pillar upper reinforcement of a vehicle is currently being produced by cold forming of DP600 steel sheet with a thickness of 1.8 mm. In this study, the possible decrease in the thickness of this particular part by using 22MnB5 as appropriate AHSS material and applying this alternative process has been studied. The proposed process involves deep drawing, trimming, heating, sizing, cooling and piercing operations. Both the current production process and the proposed process are analyzed by the finite element method. The die geometry, blank holding forces and the design of the cooling channels for the cooling process are determined numerically. It is shown that the particular part made of 22MnB5 steel sheet with a thickness of 1.2 mm can be successfully produced by applying the proposed process sequence and can be used without sacrificing the crashworthiness. With the use of the 22MnB5 steel with a thickness of 1.2 mm instead of DP600 sheet metal with a thickness of 1.8 mm, the weight is reduced by approximately 33%.

Societal cost-benefit analysis for soil remediation in The Netherlands.

PubMed

van Wezel, Annemarie P; Franken, Ron O G; Drissen, Eric; Versluijs, Kees C W; van den Berg, Reinier

2008-01-01

There is a political demand on the efficiency of environmental policy. Cost-benefit analyses (CBAs) can play a role in answering that demand. This societal CBA for nationwide soil remediation operations in The Netherlands distinguishes 4 alternatives for future investments. In the zero alternative government funding will be terminated. Besides this, 3 policy alternatives are distinguished that are government financed. Soil remediation benefits human health, the drinking water supply, housing, perceptions, and the ecosystem. Soil remediation also answers the concerns of the Dutch population. The benefits to health (exposure to cadmium, lead, and carcinogens), drinking water supply, and housing are expressed in monetary terms. The extent that benefits equal the money spent depends partly on the value-loaded choice for the discount rate. Use of the current discount rate of 4% will mean a slightly negative balance whichever policy alternative is chosen. Focusing on nonmoneterized benefits, such as ecology, can cause the scales to tip in another direction. Using a lower discount rate will make future benefits, such as health and drinking water supply, more important. If the discount rate drops to 2% or less, all policy alternatives lead to a positive balance. Predominantly, the health benefits that are veiled in uncertainty can become a reason for applying a surcharge and, in turn, a higher discount rate. In that case, each of the alternatives will result in a net negative balance.

40 CFR 80.350 - What alternative sulfur standards and requirements apply to importers who transport gasoline by...

Code of Federal Regulations, 2011 CFR

2011-07-01

... requirements apply to importers who transport gasoline by truck? 80.350 Section 80.350 Protection of... ADDITIVES Gasoline Sulfur Sampling, Testing and Retention Requirements for Refiners and Importers § 80.350 What alternative sulfur standards and requirements apply to importers who transport gasoline by truck...

40 CFR 80.350 - What alternative sulfur standards and requirements apply to importers who transport gasoline by...

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements apply to importers who transport gasoline by truck? 80.350 Section 80.350 Protection of... ADDITIVES Gasoline Sulfur Sampling, Testing and Retention Requirements for Refiners and Importers § 80.350 What alternative sulfur standards and requirements apply to importers who transport gasoline by truck...

40 CFR 80.350 - What alternative sulfur standards and requirements apply to importers who transport gasoline by...

Code of Federal Regulations, 2013 CFR

2013-07-01

... requirements apply to importers who transport gasoline by truck? 80.350 Section 80.350 Protection of... ADDITIVES Gasoline Sulfur Sampling, Testing and Retention Requirements for Refiners and Importers § 80.350 What alternative sulfur standards and requirements apply to importers who transport gasoline by truck...

40 CFR 80.350 - What alternative sulfur standards and requirements apply to importers who transport gasoline by...

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements apply to importers who transport gasoline by truck? 80.350 Section 80.350 Protection of... ADDITIVES Gasoline Sulfur Sampling, Testing and Retention Requirements for Refiners and Importers § 80.350 What alternative sulfur standards and requirements apply to importers who transport gasoline by truck...

40 CFR 80.350 - What alternative sulfur standards and requirements apply to importers who transport gasoline by...

Code of Federal Regulations, 2012 CFR

2012-07-01

... requirements apply to importers who transport gasoline by truck? 80.350 Section 80.350 Protection of... ADDITIVES Gasoline Sulfur Sampling, Testing and Retention Requirements for Refiners and Importers § 80.350 What alternative sulfur standards and requirements apply to importers who transport gasoline by truck...

Safe Direct Current Stimulation to Expand Capabilities of Neural Prostheses

PubMed Central

Fridman, Gene Y.; Della Santina, Charles C.

2014-01-01

While effective in treating some neurological disorders, neuroelectric prostheses are fundamentally limited because they must employ charge-balanced stimuli to avoid evolution of irreversible electrochemical reactions and their byproducts at the interface between metal electrodes and body fluids. Charge-balancing is typically achieved by using brief biphasic alternating current (AC) pulses, which typically excite nearby neural tissues but cannot efficiently inhibit them. In contrast, direct current (DC) applied via a metal electrode in contact with body fluids can excite, inhibit and modulate sensitivity of neurons; however, DC stimulation is biologically unsafe because it violates “safe charge injection” limits that have long been considered unavoidable constraints. In this report, we describe the design and fabrication of a safe DC stimulator (SDCS) that overcomes this constraint. The SCDS drives DC ionic current into target tissue via salt-bridge micropipette electrodes by switching valves in phase with AC square waves applied to metal electrodes contained within the device. This approach achieves DC ionic flow through tissue while still adhering to charge-balancing constraints at each electrode-saline interface. We show the SDCS’s ability to both inhibit and excite neural activity to achieve improved dynamic range during prosthetic stimulation of the vestibular part of the inner ear in chinchillas. PMID:23476007

Investigating Effects of Nano- to Micro-Ampere Alternating Current Stimulation on Trichophyton rubrum Growth.

PubMed

Kwon, Dong Rak; Kwon, Hyunjung; Lee, Woo Ram; Park, Joonsoo

2016-10-01

Fungi are eukaryotic microorganisms including yeast and molds. Many studies have focused on modifying bacterial growth, but few on fungal growth. Microcurrent electricity may stimulate fungal growth. This study aims to investigate effects of microcurrent electric stimulation on Trichophyton rubrum growth. Standard-sized inoculums of T. rubrum derived from a spore suspension were applied to potato dextrose cornmeal agar (PDACC) plates, gently withdrawn with a sterile pipette, and were applied to twelve PDACC plates with a sterile spreader. Twelve Petri dishes were divided into four groups. The given amperage of electric current was 500 nA, 2 µA, and 4 µA in groups A, B, and C, respectively. No electric current was given in group D. In the first 48 hours, colonies only appeared in groups A and B (500 nA and 2 µA exposure). Colonies in group A (500 nA) were denser. Group C (4 µA) plates showed a barely visible film of fungus after 96 hours of incubation. Fungal growth became visible after 144 hours in the control group. Lower intensities of electric current caused faster fungal growth within the amperage range used in this study. Based on these results, further studies with a larger sample size, various fungal species, and various intensities of electric stimulation should be conducted.

Design of a GaAs/Ge Solar Array for Unmanned Aerial Vehicles

NASA Technical Reports Server (NTRS)

Scheiman, David A.; Brinker, David J.; Bents, David J.; Colozza, Anthony J.

1995-01-01

Unmanned Aerial Vehicles (UAV) are being proposed for many applications including surveillance, mapping and atmospheric studies. These applications require a lightweight, low speed, medium to long duration airplane. Due to the weight, speed, and altitude constraints imposed on such aircraft, solar array generated electric power is a viable alternative to air-breathing engines. Development of such aircraft is currently being funded under the Environmental Research Aircraft and Sensor Technology (ERAST) program. NASA Lewis Research Center (LeRC) is currently building a Solar Electric Airplane to demonstrate UAV technology. This aircraft utilizes high efficiency Applied Solar Energy Corporation (ASEC) GaAs/Ge space solar cells. The cells have been provided by the Air Force through the ManTech Office. Expected completion of the plane is early 1995, with the airplane currently undergoing flight testing using battery power.

Compensation of the sheath effects in cylindrical floating probes

NASA Astrophysics Data System (ADS)

Park, Ji-Hwan; Chung, Chin-Wook

2018-05-01

In cylindrical floating probe measurements, the plasma density and electron temperature are overestimated due to sheath expansion and oscillation. To reduce these sheath effects, a compensation method based on well-developed floating sheath theories is proposed and applied to the floating harmonic method. The iterative calculation of the Allen-Boyd-Reynolds equation can derive the floating sheath thickness, which can be used to calculate the effective ion collection area; in this way, an accurate ion density is obtained. The Child-Langmuir law is used to calculate the ion harmonic currents caused by sheath oscillation of the alternating-voltage-biased probe tip. Accurate plasma parameters can be obtained by subtracting these ion harmonic currents from the total measured harmonic currents. Herein, the measurement principles and compensation method are discussed in detail and an experimental demonstration is presented.

Design of a GaAs/Ge solar array for unmanned aerial vehicles

NASA Astrophysics Data System (ADS)

Scheiman, David A.; Brinker, David J.; Bents, David J.; Colozza, Anthony J.

1995-03-01

Unmanned Aerial Vehicles (UAV) are being proposed for many applications including surveillance, mapping and atmospheric studies. These applications require a lightweight, low speed, medium to long duration airplane. Due to the weight, speed, and altitude constraints imposed on such aircraft, solar array generated electric power is a viable alternative to air-breathing engines. Development of such aircraft is currently being funded under the Environmental Research Aircraft and Sensor Technology (ERAST) program. NASA Lewis Research Center (LeRC) is currently building a Solar Electric Airplane to demonstrate UAV technology. This aircraft utilizes high efficiency Applied Solar Energy Corporation (ASEC) GaAs/Ge space solar cells. The cells have been provided by the Air Force through the ManTech Office. Expected completion of the plane is early 1995, with the airplane currently undergoing flight testing using battery power.

Shunt attachment and method for interfacing current collection systems

DOEpatents

Denney, P.E.; Iyer, N.C.; Hannan, W.F. III.

1992-12-08

A composite brush to shunt attachment wherein a volatile component of a composite but mostly metallic brush, used for current collection purposes, does not upon welding or brazing, adversely affect the formation of the interfacial bond with a conductive shunt which carries the current from the zone of the brush. The brush to shunt attachment for a brush material of copper-graphite composite and a shunt of copper, or substituting silver for copper as an alternative, is made through a hot isostatic pressing (HIP). The HIP process includes applying high pressure and temperature simultaneously at the brush to shunt interface, after it has been isolated or canned in a metal casing in which the air adjacent to the interface has been evacuated and the interfacial area has been sealed before the application of pressure and temperature. 6 figs.

Shunt attachment and method for interfacing current collection systems

DOEpatents

Denney, Paul E.; Iyer, Natraj C.; Hannan, III, William F.

1992-01-01

A composite brush to shunt attachment wherein a volatile component of a composite but mostly metallic brush, used for current collection purposes, does not upon welding or brazing, adversely affect the formation of the interfacial bond with a conductive shunt which carries the current from the zone of the brush. The brush to shunt attachment for a brush material of copper-graphite composite and a shunt of copper, or substituting silver for copper as an alternative, is made through a hot isostatic pressing (HIP). The HIP process includes applying high pressure and temperature simultaneously at the brush to shunt interface, after it has been isolated or canned in a metal casing in which the air adjacent to the interface has been evacuated and the interfacial area has been sealed before the application of pressure and temperature.

A comparison of alternative medicare reimbursement policies under optimal hospital pricing.

PubMed Central

Dittman, D A; Morey, R C

1983-01-01

This paper applies and extends the use of a nonlinear hospital pricing model, recently posited in the literature by Dittman and Morey [1]. That model applied a hospital profit-maximizing behavior and studied the effects of optimal pricing of hospital ancillary services on the incidence of payment by private insurance companies and the Medicare trust fund. Here, we examine variations of the above model where both hospital profit-maximizing and profit-satisficing postures are of interest. We apply the model to three types of Medicare reimbursement policies currently in use or under legislative mandate to implement. The policies differ according to hospital size and whether cross-subsidies are allowed. We are interested in determining the effects of profit-maximizing and -satisficing behaviors of these three reimbursement policies on the levels of profits received, and on the respective implications for private payors and the Medicare trust fund. PMID:6347973

Application of active electrode compensation to perform continuous voltage-clamp recordings with sharp microelectrodes.

PubMed

Gómez-González, J F; Destexhe, A; Bal, T

2014-10-01

Electrophysiological recordings of single neurons in brain tissues are very common in neuroscience. Glass microelectrodes filled with an electrolyte are used to impale the cell membrane in order to record the membrane potential or to inject current. Their high resistance induces a high voltage drop when passing current and it is essential to correct the voltage measurements. In particular, for voltage clamping, the traditional alternatives are two-electrode voltage-clamp technique or discontinuous single electrode voltage-clamp (dSEVC). Nevertheless, it is generally difficult to impale two electrodes in a same neuron and the switching frequency is limited to low frequencies in the case of dSEVC. We present a novel fully computer-implemented alternative to perform continuous voltage-clamp recordings with a single sharp-electrode. To reach such voltage-clamp recordings, we combine an active electrode compensation algorithm (AEC) with a digital controller (AECVC). We applied two types of control-systems: a linear controller (proportional plus integrative controller) and a model-based controller (optimal control). We compared the performance of the two methods to dSEVC using a dynamic model cell and experiments in brain slices. The AECVC method provides an entirely digital method to perform continuous recording and smooth switching between voltage-clamp, current clamp or dynamic-clamp configurations without introducing artifacts.

Lease vs. Purchase Analysis of Alternative Fuel Vehicles in the United States Marine Corps

DTIC Science & Technology

2009-12-01

data (2004 to 2009) for the largest populations of AFVs in the light-duty category and then apply a model that will compare the two alternatives based...the largest populations of AFVs in the light-duty category and then apply a model that will compare the two alternatives based on their relative net...28 IV. THE MODEL

40 CFR 1045.645 - What special provisions apply for converting an engine to use an alternate fuel?

Code of Federal Regulations, 2010 CFR

2010-07-01

... converting an engine to use an alternate fuel? 1045.645 Section 1045.645 Protection of Environment... for converting an engine to use an alternate fuel? A certificate of conformity is no longer valid for.... This section applies if such modifications are done to convert the engine to run on a different fuel...

40 CFR 1051.650 - What special provisions apply for converting a vehicle to use an alternate fuel?

Code of Federal Regulations, 2010 CFR

2010-07-01

... converting a vehicle to use an alternate fuel? 1051.650 Section 1051.650 Protection of Environment... vehicle to use an alternate fuel? A certificate of conformity is no longer valid for a vehicle if the... applies if such modifications are done to convert the vehicle to run on a different fuel type. Such...

40 CFR 1054.645 - What special provisions apply for converting an engine to use an alternate fuel?

Code of Federal Regulations, 2010 CFR

2010-07-01

... converting an engine to use an alternate fuel? 1054.645 Section 1054.645 Protection of Environment... apply for converting an engine to use an alternate fuel? A certificate of conformity is no longer valid... fuel type. Such engines may need to be recertified as specified in this section if the certificate is...

A framework for an alternatives assessment dashboard for evaluating chemical alternatives applied to flame retardants for electronic applications

EPA Science Inventory

The goal of alternatives assessment (AA) is to facilitate a comparison of alternatives to a chemical of concern, resulting in the identification of safer alternatives. A two-stage methodology for comparing chemical alternatives was developed. In the first stage, alternatives are ...

Applying visual attention theory to transportation safety research and design: evaluation of alternative automobile rear lighting systems.

PubMed

McIntyre, Scott E; Gugerty, Leo

2014-06-01

This field experiment takes a novel approach in applying methodologies and theories of visual search to the subject of conspicuity in automobile rear lighting. Traditional rear lighting research has not used the visual search paradigm in experimental design. It is our claim that the visual search design uniquely uncovers visual attention processes operating when drivers search the visual field that current designs fail to capture. This experiment is a validation and extension of previous simulator research on this same topic and demonstrates that detection of red automobile brake lamps will be improved if tail lamps are another color (in this test, amber) rather than the currently mandated red. Results indicate that when drivers miss brake lamp onset in low ambient light, RT and error are reduced in detecting the presence and absence of red brake lamps with multiple lead vehicles when tail lamps are not red compared to current rear lighting which mandates red tail lamps. This performance improvement is attributed to efficient visual processing that automatically segregates tail (amber) and brake (red) lamp colors into distractors and targets respectively. Copyright © 2014 Elsevier Ltd. All rights reserved.

Qumquad: a UML-based approach for remodeling of legacy systems in health care.

PubMed

Garde, Sebastian; Knaup, Petra; Herold, Ralf

2003-07-01

Health care information systems still comprise legacy systems to a certain extent. For reengineering legacy systems a thorough remodeling is inalienable. Current modeling techniques like the Unified Modeling Language (UML) do not offer a systematic and comprehensive process-oriented method for remodeling activities. We developed a systematic method for remodeling legacy systems in health care called Qumquad. Qumquad consists of three major steps: (i) modeling the actual state of the application system, (ii) systematic identification of weak points in this model and (iii) development of a target concept for the reimplementation considering the identified weak points. We applied Qumquad for remodeling a documentation and therapy planning system for pediatric oncology (DOSPO). As a result of our remodeling activities we regained an abstract model of the system, an analysis of the current weak points of DOSPO and possible (partly alternative) solutions to overcome the weak points. Qumquad proved to be very helpful in the reengineering process of DOSPO since we now have at our disposal a comprehensive model for the reimplementation of DOSPO that current users of the system agree on. Qumquad can easily be applied to other reengineering projects in health care.

Characterization of RPC operation with new environmental friendly mixtures for LHC application and beyond

NASA Astrophysics Data System (ADS)

Guida, R.; Capeans, M.; Mandelli, B.

2016-07-01

The large muon trigger systems based on Resistive Plate Chambers (RPC) at the LHC experiments are currently operated with R134a based mixture. Unfortunately R134a is considered a greenhouse gas with high impact on the enviroment and therefore will be subject to regulations aiming in strongly reducing the available quantity on the market. The immediat effects might be instability on the price and incertitude in the product availability. Alternative gases (HFO-1234yf and HFO-1234ze) have been already identified by industry for specific applications as replacement of R134a. Moreover, HFCs similar to the R134a but with lower global warming potential (GWP) are already available (HFC-245fa, HFC-32, HFC-152a). The present contribution describes the results obtained with RPCs operated with new enviromemtal friendly gases. A particular attention has been addressed to the possibility of maintening the current operation conditions (i.e. currently used applied voltage and front-end electronics) in order to be able to use a new mixture for RPC systems even where the common infrastructure (i.e. high voltage and detector components) cannot be replaced for operation at higher applied voltages.

In vivo mapping of current density distribution in brain tissues during deep brain stimulation (DBS)

NASA Astrophysics Data System (ADS)

Sajib, Saurav Z. K.; Oh, Tong In; Kim, Hyung Joong; Kwon, Oh In; Woo, Eung Je

2017-01-01

New methods for in vivo mapping of brain responses during deep brain stimulation (DBS) are indispensable to secure clinical applications. Assessment of current density distribution, induced by internally injected currents, may provide an alternative method for understanding the therapeutic effects of electrical stimulation. The current flow and pathway are affected by internal conductivity, and can be imaged using magnetic resonance-based conductivity imaging methods. Magnetic resonance electrical impedance tomography (MREIT) is an imaging method that can enable highly resolved mapping of electromagnetic tissue properties such as current density and conductivity of living tissues. In the current study, we experimentally imaged current density distribution of in vivo canine brains by applying MREIT to electrical stimulation. The current density maps of three canine brains were calculated from the measured magnetic flux density data. The absolute current density values of brain tissues, including gray matter, white matter, and cerebrospinal fluid were compared to assess the active regions during DBS. The resulting current density in different tissue types may provide useful information about current pathways and volume activation for adjusting surgical planning and understanding the therapeutic effects of DBS.

30 CFR 75.900 - Low- and medium-voltage circuits serving three-phase alternating current equipment; circuit...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Low- and medium-voltage circuits serving three... STANDARDS-UNDERGROUND COAL MINES Underground Low- and Medium-Voltage Alternating Current Circuits § 75.900 Low- and medium-voltage circuits serving three-phase alternating current equipment; circuit breakers...

30 CFR 77.900 - Low- and medium-voltage circuits serving portable or mobile three-phase alternating current...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Low- and medium-voltage circuits serving... Medium-Voltage Alternating Current Circuits § 77.900 Low- and medium-voltage circuits serving portable or mobile three-phase alternating current equipment; circuit breakers. Low- and medium-voltage circuits...

30 CFR 75.900 - Low- and medium-voltage circuits serving three-phase alternating current equipment; circuit...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Low- and medium-voltage circuits serving three... STANDARDS-UNDERGROUND COAL MINES Underground Low- and Medium-Voltage Alternating Current Circuits § 75.900 Low- and medium-voltage circuits serving three-phase alternating current equipment; circuit breakers...

30 CFR 75.900 - Low- and medium-voltage circuits serving three-phase alternating current equipment; circuit...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Low- and medium-voltage circuits serving three... STANDARDS-UNDERGROUND COAL MINES Underground Low- and Medium-Voltage Alternating Current Circuits § 75.900 Low- and medium-voltage circuits serving three-phase alternating current equipment; circuit breakers...

30 CFR 77.900 - Low- and medium-voltage circuits serving portable or mobile three-phase alternating current...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Low- and medium-voltage circuits serving... Medium-Voltage Alternating Current Circuits § 77.900 Low- and medium-voltage circuits serving portable or mobile three-phase alternating current equipment; circuit breakers. Low- and medium-voltage circuits...

30 CFR 77.900 - Low- and medium-voltage circuits serving portable or mobile three-phase alternating current...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Low- and medium-voltage circuits serving... Medium-Voltage Alternating Current Circuits § 77.900 Low- and medium-voltage circuits serving portable or mobile three-phase alternating current equipment; circuit breakers. Low- and medium-voltage circuits...

30 CFR 77.701-1 - Approved methods of grounding of equipment receiving power from ungrounded alternating current...

Code of Federal Regulations, 2013 CFR

2013-07-01

... receiving power from ungrounded alternating current power systems. 77.701-1 Section 77.701-1 Mineral... power systems. For purposes of grounding metallic frames, casings and other enclosures of equipment receiving power from ungrounded alternating current power systems, the following methods of grounding will...

30 CFR 77.701-1 - Approved methods of grounding of equipment receiving power from ungrounded alternating current...

Code of Federal Regulations, 2012 CFR

2012-07-01

... receiving power from ungrounded alternating current power systems. 77.701-1 Section 77.701-1 Mineral... power systems. For purposes of grounding metallic frames, casings and other enclosures of equipment receiving power from ungrounded alternating current power systems, the following methods of grounding will...

30 CFR 77.701-1 - Approved methods of grounding of equipment receiving power from ungrounded alternating current...

Code of Federal Regulations, 2014 CFR

2014-07-01

... receiving power from ungrounded alternating current power systems. 77.701-1 Section 77.701-1 Mineral... power systems. For purposes of grounding metallic frames, casings and other enclosures of equipment receiving power from ungrounded alternating current power systems, the following methods of grounding will...

40 CFR 80.1641 - Alternative sulfur standards and requirements that apply to importers who transport gasoline by...

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements that apply to importers who transport gasoline by truck. 80.1641 Section 80.1641 Protection of... ADDITIVES Gasoline Sulfur § 80.1641 Alternative sulfur standards and requirements that apply to importers who transport gasoline by truck. Importers who import gasoline into the United States by truck may...

Decision-Making Strategy for Rectal Cancer Management Using Radiation Therapy for Elderly or Comorbid Patients.

PubMed

Wang, Shang-Jui; Hathout, Lara; Malhotra, Usha; Maloney-Patel, Nell; Kilic, Sarah; Poplin, Elizabeth; Jabbour, Salma K

2018-03-15

Rectal cancer predominantly affects patients older than 70 years, with peak incidence at age 80 to 85 years. However, the standard treatment paradigm for rectal cancer oftentimes cannot be feasibly applied to these patients owing to frailty or comorbid conditions. There are currently little information and no treatment guidelines to help direct therapy for patients who are elderly and/or have significant comorbidities, because most are not included or specifically studied in clinical trials. More recently various alternative treatment options have been brought to light that may potentially be utilized in this group of patients. This critical review examines the available literature on alternative therapies for rectal cancer and proposes a treatment algorithm to help guide clinicians in treatment decision making for elderly and comorbid patients. Copyright © 2017 Elsevier Inc. All rights reserved.

Solid state fermentation (SSF): diversity of applications to valorize waste and biomass.

PubMed

Lizardi-Jiménez, M A; Hernández-Martínez, R

2017-05-01

Solid state fermentation is currently used in a range of applications including classical applications, such as enzyme or antibiotic production, recently developed products, such as bioactive compounds and organic acids, new trends regarding bioethanol and biodiesel as sources of alternative energy, and biosurfactant molecules with environmental purposes of valorising unexploited biomass. This work summarizes the diversity of applications of solid state fermentation to valorize biomass regarding alternative energy and environmental purposes. The success of applying solid state fermentation to a specific process is affected by the nature of specific microorganisms and substrates. An exhaustive number of microorganisms able to grow in a solid matrix are presented, including fungus such as Aspergillus or Penicillum for antibiotics, Rhizopus for bioactive compounds, Mortierella for biodiesel to bacteria, Bacillus for biosurfactant production, or yeast for bioethanol.

75 FR 12726 - Availability of Seats for the Channel Islands National Marine Sanctuary Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

...: Tourism alternate, Recreational Fishing member and alternate, Education member and alternate, Public at Large alternates (2), Chuinash Community member and alternate, Business alternate, and Commercial... to the seat for which they are applying; community and professional affiliations; views regarding the...

Characterization of polymer, DNA-based, and silk thin film resistivities and of DNA-based films prepared for enhanced electrical conductivity

NASA Astrophysics Data System (ADS)

Yaney, Perry P.; Ouchen, Fahima; Grote, James G.

2009-08-01

DC resistivity studies were carried out on biopolymer films of DNA-CTMA and silk fibroin, and on selected traditional polymer films, including PMMA and APC. Films of DNA-CTMA versus molecular weight and with conductive dopants PCBM, BAYTRON P and ammonium tetrachloroplatinate are reported. The films were spin coated on glass slides configured for measurements of volume dc resistance. The measurements used the alternating polarity method to record the applied voltage-dependent current independent of charging and background currents. The Arrhenius equation plus a constant was fitted to the conductivity versus temperature data of the polymers and the non-doped DNA-based biopolymers with activation energies ranging from 0.8 to 1.4 eV.

Studies on Methanol Crossover in Liquid-Feed Direct Methanol Pem Fuel Cells

NASA Technical Reports Server (NTRS)

Narayanan, S. R.

1995-01-01

The performance of liquid feed direct methanol fuel cells using various types of Nafion membranes as the solid polymer electrolyte have been studied. The rate of fuel crossover and electrical performance has been measured for cells with Nafion membranes of various thicknesses and equivalent weights. The crossover rate is found to decrease with increasing thickness and applied current. The dependence of crossover rate on current density can be understood in terms of a simple linear diffusion model which suggests that the crossover rate can be influenced by the electrode structure in addition to the membrane. The studies suggest that Nafion EW 1500 is a very promising alternate to Nafion EW 1100 for direct methanol fuel cells.

Two-step purification of scutellarin from Erigeron breviscapus (vant.) Hand. Mazz. by high-speed counter-current chromatography.

PubMed

Gao, Min; Gu, Ming; Liu, Chun-Zhao

2006-07-11

Scutellarin, a flavone glycoside, popularly applied for the treatment of cardiopathy, has been purified in two-step purification by high-speed counter-current chromatography (HSCCC) from Erigeron breviscapus (vant.) Hand. Mazz. (Deng-zhan-hua in Chinese), a well-known traditional Chinese medicinal plant for heart disease. Two solvent systems, n-hexane-ethyl acetate-methanol-acetic acid-water (1:6:1.5:1:4, v/v/v/v/v) and ethyl acetate-n-butanol-acetonitrile-0.1% HCl (5:2:5:10, v/v/v/v) were used for the two-step purification. The purity of the collected fraction of scutellarin was 95.6%. This study supplies a new alternative method for purification of scutellarin.

Model falsifiability and climate slow modes

NASA Astrophysics Data System (ADS)

Essex, Christopher; Tsonis, Anastasios A.

2018-07-01

The most advanced climate models are actually modified meteorological models attempting to capture climate in meteorological terms. This seems a straightforward matter of raw computing power applied to large enough sources of current data. Some believe that models have succeeded in capturing climate in this manner. But have they? This paper outlines difficulties with this picture that derive from the finite representation of our computers, and the fundamental unavailability of future data instead. It suggests that alternative windows onto the multi-decadal timescales are necessary in order to overcome the issues raised for practical problems of prediction.

Advanced Computing Technologies for Rocket Engine Propulsion Systems: Object-Oriented Design with C++

NASA Technical Reports Server (NTRS)

Bekele, Gete

2002-01-01

This document explores the use of advanced computer technologies with an emphasis on object-oriented design to be applied in the development of software for a rocket engine to improve vehicle safety and reliability. The primary focus is on phase one of this project, the smart start sequence module. The objectives are: 1) To use current sound software engineering practices, object-orientation; 2) To improve on software development time, maintenance, execution and management; 3) To provide an alternate design choice for control, implementation, and performance.

Adaptation responses to increasing drought frequency

NASA Astrophysics Data System (ADS)

Loch, A. J.; Adamson, D. C.; Schwabe, K.

2016-12-01

Using state contingent analysis we discuss how and why irrigators adapt to alternative water supply signals. This analysis approach helps to illustrate how and why producers currently use state-general and state-allocable inputs to adapt and respond to known and possible future climatic alternative natures. Focusing on the timing of water allocations, we explore inherent differences in the demand for water by two key irrigation sectors: annual and perennial producers which in Australia have allowed a significant degree of risk-minimisation during droughts. In the absence of land constraints, producers also had a capacity to respond to positive state outcomes and achieve super-normal profits. In the future, however, the probability of positive state outcomes is uncertain; production systems may need to adapt to minimise losses and/or achieve positive returns under altered water supply conditions that may arise as a consequence of more frequent drought states. As such, producers must assess whether altering current input/output choice sets in response to possible future climate states will enhance their long-run competitive advantage for both expected new normal and extreme water supply outcomes. Further, policy supporting agricultural sector climate change resilience must avoid poorly-designed strategies that increase producer vulnerability in the face of drought. Our analysis explores the reliability of alternative water property right bundles and how reduced allocations across time influence alternative responses by producers. We then extend our analysis to explore how management strategies could adapt to two possible future drier state types: i) where an average reduction in water supply is experienced; and ii) where the frequency of droughts increase. The combination of these findings are subsequently used to discuss the role water reform policy has to deal with current and future climate scenarios. We argue current policy strategies could drive producers to more homogeneous production systems over time, which ultimately entail risky adaptation options under future water supply availability or increased drought frequency scenarios. Lastly, our analysis has shown the flexibility of applying SCA toward examining uncertainty surrounding future states of nature under climate change.

Transcranial alternating current stimulation modulates auditory temporal resolution in elderly people.

PubMed

Baltus, Alina; Vosskuhl, Johannes; Boetzel, Cindy; Herrmann, Christoph Siegfried

2018-05-13

Recent research provides evidence for a functional role of brain oscillations for perception. For example, auditory temporal resolution seems to be linked to individual gamma frequency of auditory cortex. Individual gamma frequency not only correlates with performance in between-channel gap detection tasks but can be modulated via auditory transcranial alternating current stimulation. Modulation of individual gamma frequency is accompanied by an improvement in gap detection performance. Aging changes electrophysiological frequency components and sensory processing mechanisms. Therefore, we conducted a study to investigate the link between individual gamma frequency and gap detection performance in elderly people using auditory transcranial alternating current stimulation. In a within-subject design, twelve participants were electrically stimulated with two individualized transcranial alternating current stimulation frequencies: 3 Hz above their individual gamma frequency (experimental condition) and 4 Hz below their individual gamma frequency (control condition) while they were performing a between-channel gap detection task. As expected, individual gamma frequencies correlated significantly with gap detection performance at baseline and in the experimental condition, transcranial alternating current stimulation modulated gap detection performance. In the control condition, stimulation did not modulate gap detection performance. In addition, in elderly, the effect of transcranial alternating current stimulation on auditory temporal resolution seems to be dependent on endogenous frequencies in auditory cortex: elderlies with slower individual gamma frequencies and lower auditory temporal resolution profit from auditory transcranial alternating current stimulation and show increased gap detection performance during stimulation. Our results strongly suggest individualized transcranial alternating current stimulation protocols for successful modulation of performance. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Preventing Childhood Anxiety Disorders: Is an Applied Game as Effective as a Cognitive Behavioral Therapy-Based Program?

PubMed

Schoneveld, Elke A; Lichtwarck-Aschoff, Anna; Granic, Isabela

2018-02-01

A large proportion of children experience subclinical levels of anxiety and cognitive-behavioral therapy (CBT) aimed at preventing anxiety disorders is moderately effective. However, most at-risk children do not seek help or drop out of programs prematurely because of stigma, lack of motivation, and accessibility barriers. Applied games have received increased attention as viable alternatives and have shown promising results, but direct comparisons between applied games and the gold-standard CBT are lacking. Our aim was to investigate whether the applied game MindLight is as effective as CBT (i.e., Coping Cat) within an indicated prevention context. We conducted a randomized controlled non-inferiority trial with a sample of 174 children (7- to 12-year olds) with elevated levels of anxiety, comparing MindLight to CBT. Anxiety was assessed with self- and parent-reports at pre- and post-program, and at 3- and 6-month follow-ups. Intention-to-treat and completers-only confidence interval approach and latent growth curve modeling showed an overall significant quadratic decrease in child- and parent-reported anxiety symptoms over time and, as predicted, the magnitude of improvement was the same for MindLight and CBT. The within-group effect sizes were small to medium at post-test (- 0.32 to - 0.63), and medium to large (- 0.60 to - 1.07) at 3- and 6-month follow-ups. Furthermore, MindLight and CBT were rated equally anxiety inducing, difficult, and appealing; CBT was rated as more relevant to daily life than MindLight. The current study adds to the growing research on applied games for mental health and shows that these games hold potential as alternative delivery models for evidence-based therapeutic techniques.

Vortex motion and dynamical states in Josephson arrays

NASA Astrophysics Data System (ADS)

Trias, Enrique

Underdamped Josephson junction arrays are used as model systems to study novel nonlinear effects. A combination of experiments, numerical simulations, and analytical analysis is used to probe different nonlinear behavior such as intrinsic localized modes, resonances in fully frustrated arrays, Meissner-like states, and vortex ratchets. Circuit models of Josephson networks are also developed, and applied to the design and measurement of parallel array oscillators. Ladder arrays have been used for an experimental study of intrinsic localized modes, or discrete breathers. Measurements of breather stability indicate that the maximum allowable bias current is proportional to the array depinning current while the minimum current is related to a junction retrapping mechanism. This retrapping instability usually leads to the formation of multi-site breathers. Collisions between the two nonlinear excitations in ladder arrays, discrete breathers and vortices, have also been numerically investigated. Discrete breathers act as pinning centers to vortex motion and the collisions can be modeled by an energy barrier activation process. When vortices are thermally induced over this barrier, a two-site breather is created. Experiments also reveal remarkable similarities among the do current-voltage characteristics of several kinds of square and triangular arrays, where two resonant voltages are observed. Simulations indicate that at full frustration a dynamical checkerboard state underlies these similarities. For such a traveling solution, the governing equations of the arrays are reduced to three coupled pendulum equations that have two characteristic resonant frequencies. Finally, a kink ratchet potential has been designed using a parallel array of Josephson junctions with alternating cell inductances and junctions areas. Experiments show that the depinning current depends on the direction of the applied current. Other properties of the depinning current versus applied field, such as a long period and a lack of reflection symmetry, have been observed and explained analytically. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139- 4307. Ph. 617-253-5668; Fax 617-253-1690.)

Relaxation time estimation in surface NMR

DOEpatents

Grunewald, Elliot D.; Walsh, David O.

2017-03-21

NMR relaxation time estimation methods and corresponding apparatus generate two or more alternating current transmit pulses with arbitrary amplitudes, time delays, and relative phases; apply a surface NMR acquisition scheme in which initial preparatory pulses, the properties of which may be fixed across a set of multiple acquisition sequence, are transmitted at the start of each acquisition sequence and are followed by one or more depth sensitive pulses, the pulse moments of which are varied across the set of multiple acquisition sequences; and apply processing techniques in which recorded NMR response data are used to estimate NMR properties and the relaxation times T.sub.1 and T.sub.2* as a function of position as well as one-dimensional and two-dimension distributions of T.sub.1 versus T.sub.2* as a function of subsurface position.

Static and Alternating Field Magnetic Capture and Heating of Iron Oxide Nanoparticles in Simulated Blood Vessels

NASA Astrophysics Data System (ADS)

Lee, Joanne Haeun; Shah, Rhythm R.; Brazel, Christopher S.

2014-11-01

Targeted drug delivery and localized hyperthermia are being studied as alternatives to conventional cancer treatments, which can affect the whole body and indiscriminately kill healthy cells. Magnetic nanoparticles (MNPs) have potential as drug carriers that can be captured and trigger hyperthermia at the site of the tumor by applying an external magnetic field. This study focuses on comparing the capture efficiency of the magnetic field applied by a static magnet to an alternating current coil. The effect of particle size, degree of dispersion, and the frequency of the AC field on capture and heating were studied using 3 different dispersions: 16 nm maghemite in water, 50 nm maghemite in dopamine, and 20--30 nm magnetite in dimercaptosuccinic acid. A 480G static field captured more MNPs than a similar 480G AC field at either 194 or 428 kHz; however, the AC field also allowed heating. The MNPs in water had a lower capture and heating efficiency than the larger, dopamine-coated MNPs. This finding was supported by dynamic light scattering data showing the particle size distribution and vibrating sample magnetometry data showing that the larger MNPs in the dopamine solution have a higher field of coercivity, exhibit ferrimagnetism and allow for better capture while smaller (16 nm) MNPs exhibit superparamagnetism. The dispersions that captured the best also heated the best. NSF ECE Grant #1358991 supported the first author as an REU student.

Temperature tuning from direct to inverted bistable electroluminescence in resonant tunneling diodes

NASA Astrophysics Data System (ADS)

Hartmann, F.; Pfenning, A.; Rebello Sousa Dias, M.; Langer, F.; Höfling, S.; Kamp, M.; Worschech, L.; Castelano, L. K.; Marques, G. E.; Lopez-Richard, V.

2017-10-01

We study the electroluminescence (EL) emission of purely n-doped resonant tunneling diodes in a wide temperature range. The paper demonstrates that the EL originates from impact ionization and radiative recombination in the extended collector region of the tunneling device. Bistable current-voltage response and EL are detected and their respective high and low states are tuned under varying temperature. The bistability of the EL intensity can be switched from direct to inverted with respect to the tunneling current and the optical on/off ratio can be enhanced with increasing temperature. One order of magnitude amplification of the optical on/off ratio can be attained compared to the electrical one. Our observation can be explained by an interplay of moderate peak-to-valley current ratios, large resonance voltages, and electron energy loss mechanisms, and thus, could be applied as an alternative route towards optoelectronic applications of tunneling devices.

Direct determination of creatinine based on poly(ethyleneimine)/phosphotungstic acid multilayer modified electrode.

PubMed

Han, Ping; Xu, Shimei; Feng, Shun; Hao, Yanjun; Wang, Jide

2016-05-01

In this work, the direct determination of creatinine was achieved using a poly(ethyleneimine)/phosphotungstic acid multilayer modified electrode with the assistance of Copper(II) ions by cyclic voltammetry. The quantity of creatinine were determined by measuring the redox peak current of Cu(II)-creatinine complex/Cu(I)-creatinine complex. Factors affecting the response current of creatinine at the modified electrode were optimized. A linear relationship between the response current and the concentration of creatinine ranging from 0.125 to 62.5μM was obtained with a detection limit of 0.06μM. The proposed method was applied to determine creatinine in human urine, and satisfied results were gotten which was validated in accordance with high performance liquid chromatography. The proposed electrode provided a promising alternative in routine sensing for creatinine without enzymatic assistance. Copyright © 2016 Elsevier B.V. All rights reserved.

Developing spatially explicit footprints of plausible land-use scenarios in the Santa Cruz Watershed, Arizona and Sonora

USGS Publications Warehouse

Norman, Laura M.; Feller, Mark; Villarreal, Miguel L.

2012-01-01

The SLEUTH urban growth model is applied to a binational dryland watershed to envision and evaluate plausible future scenarios of land use change into the year 2050. Our objective was to create a suite of geospatial footprints portraying potential land use change that can be used to aid binational decision-makers in assessing the impacts relative to sustainability of natural resources and potential socio-ecological consequences of proposed land-use management. Three alternatives are designed to simulate different conditions: (i) a Current Trends Scenario of unmanaged exponential growth, (ii) a Conservation Scenario with managed growth to protect the environment, and (iii) a Megalopolis Scenario in which growth is accentuated around a defined international trade corridor. The model was calibrated with historical data extracted from a time series of satellite images. Model materials, methodology, and results are presented. Our Current Trends Scenario predicts the footprint of urban growth to approximately triple from 2009 to 2050, which is corroborated by local population estimates. The Conservation Scenario results in protecting 46% more of the Evergreen class (more than 150,000 acres) than the Current Trends Scenario and approximately 95,000 acres of Barren Land, Crops, Deciduous Forest (Mesquite Bosque), Grassland/Herbaceous, Urban/Recreational Grasses, and Wetlands classes combined. The Megalopolis Scenario results also depict the preservation of some of these land-use classes compared to the Current Trends Scenario, most notably in the environmentally important headwaters region. Connectivity and areal extent of land cover types that provide wildlife habitat were preserved under the alternative scenarios when compared to Current Trends.

Dynamics of laser-guided alternating current high voltage discharges

NASA Astrophysics Data System (ADS)

Daigle, J.-F.; Théberge, F.; Lassonde, P.; Kieffer, J.-C.; Fujii, T.; Fortin, J.; Châteauneuf, M.; Dubois, J.

2013-10-01

The dynamics of laser-guided alternating current high voltage discharges are characterized using a streak camera. Laser filaments were used to trigger and guide the discharges produced by a commercial Tesla coil. The streaking images revealed that the dynamics of the guided alternating current high voltage corona are different from that of a direct current source. The measured effective corona velocity and the absence of leader streamers confirmed that it evolves in a pure leader regime.

Micro-hole array fluorescent sensor based on AC-Dielectrophoresis (DEP) for simultaneous analysis of nano-molecules

NASA Astrophysics Data System (ADS)

Kim, Hye Jin; Kang, Dong-Hoon; Lee, Eunji; Hwang, Kyo Seon; Shin, Hyun-Joon; Kim, Jinsik

2018-02-01

We propose a simple fluorescent bio-chip based on two types of alternative current-dielectrophoretic (AC-DEP) force, attractive (positive DEP) and repulsive (negative DEP) force, for simultaneous nano-molecules analysis. Various radius of micro-holes on the bio-chip are designed to apply the different AC-DEP forces, and the nano-molecules are concentrated inside the micro-hole arrays according to the intensity of the DEP force. The bio-chip was fabricated by Micro Electro Mechanical system (MEMS) technique, and was composed of two layers; a SiO2 layer and Ta/Pt layer were accomplished for an insulation layer and a top electrode with micro-hole arrays to apply electric fields for DEP force, respectively. Each SiO2 and Ta/Pt layers were deposited by thermal oxidation and sputtering, and micro-hole arrays were fabricated with Inductively Coupled Plasma (ICP) etching process. For generation of each positive and negative DEP at micro-holes, we applied two types of sine-wave AC voltage with different frequency range alternately. The intensity of the DEP force was controlled by the radius of the micro-hole and size of nano-molecule, and calculated with COMSOL multi-physics. Three types of nano-molecules labelled with different fluorescent dye were used and the intensity of nano-molecules was examined by the fluorescent optical analysis after applying the DEP force. By analyzing the fluorescent intensities of the nano-molecules, we verify the various nano-molecules in analyte are located successfully inside corresponding micro-holes with different radius according to their size.

Alternative Sigma Factor Over-Expression Enables Heterologous Expression of a Type II Polyketide Biosynthetic Pathway in Escherichia coli

PubMed Central

Stevens, David Cole; Conway, Kyle R.; Pearce, Nelson; Villegas-Peñaranda, Luis Roberto; Garza, Anthony G.; Boddy, Christopher N.

2013-01-01

Background Heterologous expression of bacterial biosynthetic gene clusters is currently an indispensable tool for characterizing biosynthetic pathways. Development of an effective, general heterologous expression system that can be applied to bioprospecting from metagenomic DNA will enable the discovery of a wealth of new natural products. Methodology We have developed a new Escherichia coli-based heterologous expression system for polyketide biosynthetic gene clusters. We have demonstrated the over-expression of the alternative sigma factor σ54 directly and positively regulates heterologous expression of the oxytetracycline biosynthetic gene cluster in E. coli. Bioinformatics analysis indicates that σ54 promoters are present in nearly 70% of polyketide and non-ribosomal peptide biosynthetic pathways. Conclusions We have demonstrated a new mechanism for heterologous expression of the oxytetracycline polyketide biosynthetic pathway, where high-level pleiotropic sigma factors from the heterologous host directly and positively regulate transcription of the non-native biosynthetic gene cluster. Our bioinformatics analysis is consistent with the hypothesis that heterologous expression mediated by the alternative sigma factor σ54 may be a viable method for the production of additional polyketide products. PMID:23724102

Hyper-Transcranial Alternating Current Stimulation: Experimental Manipulation of Inter-Brain Synchrony

PubMed Central

Szymanski, Caroline; Müller, Viktor; Brick, Timothy R.; von Oertzen, Timo; Lindenberger, Ulman

2017-01-01

We walk together, we watch together, we win together: Interpersonally coordinated actions are omnipresent in everyday life, yet the associated neural mechanisms are not well understood. Available evidence suggests that the synchronization of oscillatory activity across brains may provide a mechanism for the temporal alignment of actions between two or more individuals. In an attempt to provide a direct test of this hypothesis, we applied transcranial alternating current stimulation simultaneously to two individuals (hyper-tACS) who were asked to drum in synchrony at a set pace. Thirty-eight female-female dyads performed the dyadic drumming in the course of 3 weeks under three different hyper-tACS stimulation conditions: same-phase-same-frequency; different-phase-different-frequency; sham. Based on available evidence and theoretical considerations, stimulation was applied over right frontal and parietal sites in the theta frequency range. We predicted that same-phase-same-frequency stimulation would improve interpersonal action coordination, expressed as the degree of synchrony in dyadic drumming, relative to the other two conditions. Contrary to expectations, both the same-phase-same-frequency and the different-phase-different-frequency conditions were associated with greater dyadic drumming asynchrony relative to the sham condition. No influence of hyper-tACS on behavioral performance was seen when participants were asked to drum separately in synchrony to a metronome. Individual and dyad preferred drumming tempo was also unaffected by hyper-tACS. We discuss limitations of the present version of the hyper-tACS paradigm, and suggest avenues for future research. PMID:29167638

Economic Need among Older Latinos: Applying The Elder Economic Security Standard™ Index

PubMed Central

Wallace, Steven P.; Padilla-Frausto, D. Imelda; Smith, Susan

2013-01-01

The first official U.S. federal poverty line was developed in the 1960s; since the mid-1990s the scientific consensus has been that it has become outdated and inaccurate. This article explains the key elements of the current federal measure that are inaccurate for older adults in general and older Latinos specifically. An alternative is described that addresses the key failings of the current measure. The alternative, the Elder Economic Security Standard™ Index (Elder Index), adapts a national methodology to the basic costs of living in California for 2007 using data from the American Community Survey, and other public data sources. The results show that the amount needed for basic economic security in California is higher than the federal poverty level in all counties, and averages about twice the federal level. Housing costs are the largest component of costs in most counties, although health care is the largest component for couples in lower housing cost counties. Among singles and couples age 65 and over in California, almost 60% of Latinos have incomes below the Elder Index compared to one-quarter of non-Latino whites. The rates are higher among renters, and older Latinos are more likely than non-Latino whites to rent. Applying the Elder Index in California documents the disproportionate rates of economic insecurity among older Latinos. The findings indicate that changes to public programs such as Social Security and Medicare that decrease benefits or increase costs will have disproportionately negative impact on the ability of most older Latinos to pay for basic needs. PMID:23857068

48 CFR 32.503-9 - Liquidation rates-alternate method.

Code of Federal Regulations, 2014 CFR

2014-10-01

...-alternate method. 32.503-9 Section 32.503-9 Federal Acquisition Regulations System FEDERAL ACQUISITION... Liquidation rates—alternate method. (a) The liquidation rate determined under 32.503-8 shall apply throughout... the alternate method in this 32.503-9. The objective of the alternate liquidation rate method is to...

48 CFR 32.503-9 - Liquidation rates-alternate method.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-alternate method. 32.503-9 Section 32.503-9 Federal Acquisition Regulations System FEDERAL ACQUISITION... Liquidation rates—alternate method. (a) The liquidation rate determined under 32.503-8 shall apply throughout... the alternate method in this 32.503-9. The objective of the alternate liquidation rate method is to...

High Frequency Alternator, Power Frequency Conversion (HFA-PFC) Technology for Lightweight Tactical Power Generation

DTIC Science & Technology

1995-09-22

Modules 345-800 Amperes/400-3000 Votts - Current and Thermal Ratings of Module * Circuit Currents Element Data Model* Current Thermal Units...IGBTs modules (Powerex) 56 Main components for rectifiers, Diode Bridge modules (Powerex) 65 Heat Sinks (Aavid Engineering) 85 Westinghouse...exciter circuit , are not reliable enough for military applications, and they were replaced by brushless alternators. The brushless AC alternator

Muscle oxygenation of vastus lateralis and medialis muscles during alternating and pulsed current electrical stimulation.

PubMed

Aldayel, Abdulaziz; Muthalib, Makii; Jubeau, Marc; McGuigan, Michael; Nosaka, Kazunori

2011-05-01

This study compared between alternating and pulsed current electrical muscle stimulation (EMS) for muscle oxygenation and blood volume during isometric contractions. Nine healthy men (23-48 years) received alternating current EMS (2500 Hz) modulated at 75 Hz on the knee extensors of one leg, and pulsed current EMS (75 Hz) for the other leg separated by 2 weeks in a randomised, counter-balanced order. Pulse duration (400 μs), on-off ratio (5-15 s) and other stimulation parameters were matched between conditions and 30 isometric contractions were induced at the knee joint angle of 100° (0° full extension). Changes in tissue oxygenation index (∆TOI) and total hemoglobin volume (∆tHb) of vastus lateralis and medialis muscles over 30 contractions were assessed by a near-infrared spectroscopy, and were compared between conditions by a two-way repeated measures ANOVA. Peak torque produced during EMS increased over 30 contractions in response to the increase in the stimulation intensity for pulsed current, but not for the alternating current EMS. The torque during each isometric contraction was less stable in alternating than pulsed current EMS. The changes in ∆TOI amplitude during relaxation phases and ∆tHb amplitude were not significantly different between conditions. However, the decreases in ∆TOI amplitude during contraction phases from baseline were significantly (P < 0.05) greater for the pulsed current than alternating current from the 18th contraction (-15.6 ± 2.3 vs. -8.9 ± 1.8%) to 30th contraction (-10.7 ± 1.8 vs. -4.8 ± 1.5%). These results suggest that the muscles were less activated in the alternating current EMS when compared with the pulsed current EMS.

30 CFR 75.900-3 - Testing, examination, and maintenance of circuit breakers; procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... current circuits serving three-phase alternating current equipment and their auxiliary devices shall be... Underground Low- and Medium-Voltage Alternating Current Circuits § 75.900-3 Testing, examination, and...

30 CFR 75.900-3 - Testing, examination, and maintenance of circuit breakers; procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... current circuits serving three-phase alternating current equipment and their auxiliary devices shall be... Underground Low- and Medium-Voltage Alternating Current Circuits § 75.900-3 Testing, examination, and...

Puffing, a novel coffee bean processing technique for the enhancement of extract yield and antioxidant capacity.

PubMed

Kim, Wooki; Kim, Sang-Youn; Kim, Dae-Ok; Kim, Byung-Yong; Baik, Moo-Yeol

2018-02-01

Puffing of coffee beans, which induces heat- and pressure-derived physicochemical changes, was applied as an alternative to roasting. Roasted or puffed coffee beans with equivalent lightness values were compared. The moisture content was higher while the crude fat and protein compositions were lower in puffed beans than in roasted beans. The pH was lower and the acid content was higher in puffed beans than in roasted beans. The roasted beans exhibited greater specific volumes, while the puffed beans displayed greater extraction yields. The trigonelline and total phenolic contents were greater in puffed beans than in roasted beans resulting in an enhanced antioxidant capacity. Sensory evaluation of roasted and puffed coffee bean brews revealed that puffing did not affect the flavor or overall acceptance. The current study provides evidence that puffing is an alternative to roasting coffee beans with various benefits. Copyright © 2017 Elsevier Ltd. All rights reserved.

Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): comparison of the performance in classification of ecstasy tablets. Part 2.

PubMed

Bonadio, Federica; Margot, Pierre; Delémont, Olivier; Esseiva, Pierre

2008-11-20

Headspace solid-phase microextraction (HS-SPME) is assessed as an alternative to liquid-liquid extraction (LLE) currently used for 3,4-methylenedioxymethampethamine (MDMA) profiling. Both methods were compared evaluating their performance in discriminating and classifying samples. For this purpose 62 different seizures were analysed using both extraction techniques followed by gas chromatography-mass spectroscopy (GC-MS). A previously validated method provided data for HS-SPME, whereas LLE data were collected applying a harmonized methodology developed and used in the European project CHAMP. After suitable pre-treatment, similarities between sample pairs were studied using the Pearson correlation. Both methods enable to distinguish between samples coming from the same pre-tabletting batches and samples coming from different pre-tabletting batches. This finding emphasizes the use of HS-SPME as an effective alternative to LLE, with additional advantages such as sample preparation and a solvent-free process.

Russell and Burch's 3Rs then and now: the need for clarity in definition and purpose.

PubMed

Tannenbaum, Jerrold; Bennett, B Taylor

2015-03-01

Russell and Burch's The Principles of Humane Experimental Technique was first published in 1959. A Special Edition containing the original text was reissued in 1992, after its ideas had gained widespread interest in the scientific community. In the Principles, Russell and Burch proposed a new applied science that would improve the treatment of laboratory animals while advancing the quality of science in studies that use animals. They introduced and defined the terms replacement, reduction, and refinement, which subsequently have become known as 'alternatives' or 'alternative methods' for minimizing the potential for animal pain and distress in biomedical research. Here we describe and explain the original definitions of the 3Rs in the Principles, examine how current definitions differ among themselves and from Russell and Burch's definitions, and suggest relevant considerations for evaluating all definitions of the 3Rs.

Alternating current electroosmotic flow in polyelectrolyte-grafted nanochannel.

PubMed

Li, Fengqin; Jian, Yongjun; Chang, Long; Zhao, Guangpu; Yang, Liangui

2016-11-01

In this work, we investigate the time periodic electroosmotic flow (EOF) of an electrolyte solution through a slit polyelectrolyte-grafted (PE-grafted) nanochannel under applied alternating current (AC) electrical field. The PE-grafted nanochannel is represented by a rigid surface covered by a polyelectrolyte layer (PEL) in a brush-like configuration. Under Debye-Hückel approximation, we obtain analytical solutions of electrical potential in decoupled regime of PE-grafted nanochannel, where the thickness of PEL is independent of the electrostatic effects triggered by polyelectrolyte charges. Based upon the electrical potential obtained above, we calculate EOF velocities with uniform and non-uniform drag coefficients for PE-grafted nanochannel and compare their results. The effects of pertinent dimensionless parameters on EOF velocity amplitude are discussed in detail. Moreover, the amplitude of EOF velocity in a PE-grafted nanochannel is compared with that in a rigid one. It is shown that larger EOF velocity and volume flow rate are found for a PE-grafted nanochannel. In addition, AC EOF velocity is further investigated. The oscillation of velocity reduces and is restricted within the region near the PEL-electrolyte interface for higher oscillating Reynolds number Re. Copyright © 2016 Elsevier B.V. All rights reserved.

Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry

NASA Astrophysics Data System (ADS)

Zhou, Xiaoyu; Liu, Xinwei; Chiang, Spencer; Cao, Wenbo; Li, Ming; Ouyang, Zheng

2018-05-01

Ion trap is an excellent platform to perform tandem mass spectrometry (MS/MS), but has an intrinsic drawback in resolving power. Using ion resonant ejection as an example, the resolution degradation can be largely attributed to the broadening of the resonant frequency band (RFB) between ion motion and driving alternative-current (AC). To solve this problem, stimulated motion suppression (STMS) was developed. The key idea of STMS is the use of two suppression alternative-current (SAC) signals, which both have reversed initial phases to the main AC. The SACs can block the unexpected sideband ion resonances (or ejections), therefore playing a key role in sharpening the RFB. The proof-of-concept has been demonstrated through ion trajectory simulations and validated experimentally. STMS provides a new and versatile means for the improvement of the ion trap resolution, which for a long time has reached the bottleneck through conventional methods, e.g., increasing the radio-frequency (RF) voltage and decreasing the mass scan rate. At the end, it is worth noting that the idea of STMS is very general and principally can be applied in any RF device for the purposes of high-resolution mass analysis and ion isolation.

Life cycle assessment for dredged sediment placement strategies.

PubMed

Bates, Matthew E; Fox-Lent, Cate; Seymour, Linda; Wender, Ben A; Linkov, Igor

2015-04-01

Dredging to maintain navigable waterways is important for supporting trade and economic sustainability. Dredged sediments are removed from the waterways and then must be managed in a way that meets regulatory standards and properly balances management costs and risks. Selection of a best management alternative often results in stakeholder conflict regarding tradeoffs between local environmental impacts associated with less expensive alternatives (e.g., open water placement), more expensive measures that require sediment disposal in constructed facilities far away (e.g., landfills), or beneficial uses that may be perceived as risky (e.g., beach nourishment or island creation). Current sediment-placement decisions often focus on local and immediate environmental effects from the sediment itself, ignoring a variety of distributed and long-term effects from transportation and placement activities. These extended effects have implications for climate change, resource consumption, and environmental and human health, which may be meaningful topics for many stakeholders not currently considered. Life-Cycle Assessment (LCA) provides a systematic and quantitative method for accounting for this wider range of impacts and benefits across all sediment management project stages and time horizons. This paper applies a cradle-to-use LCA to dredged-sediment placement through a comparative analysis of potential upland, open water, and containment-island placement alternatives in the Long Island Sound region of NY/CT. Results suggest that, in cases dealing with uncontaminated sediments, upland placement may be the most environmentally burdensome alternative, per ton-kilometer of placed material, due to the emissions associated with diesel fuel combustion and electricity production and consumption required for the extra handling and transportation. These results can be traded-off with the ecosystem impacts of the sediments themselves in a decision-making framework. Published by Elsevier B.V.

Using Object-Oriented Databases for Implementation of Interactive Electronic Technical Manuals

DTIC Science & Technology

1992-03-01

analytical process applied throughout the system acquisition program in order to define supportability related design factors and to ensure development of a...Node Alternatives Node Alternatives (NODEALTS) is a list of mutually exclusive nodes, grouped together by the fact that they apply to different...contextual situations. The content specific layer NODEALTS element is a reference to a set of nodes that might apply in different situations. No hierarchy

R744 ejector technology future perspectives

NASA Astrophysics Data System (ADS)

Hafner, Armin; Banasiak, Krzysztof

2016-09-01

Carbon Dioxide, CO2 (R744) was one of the first commonly applied working fluids in the infancy of refrigeration more than 100 years ago. In contrast to ammonia it mainly disappeared after the first generation of synthetic refrigerants have been introduced to the market after 1930. One reason was that the transition from low-rpm belt driven compressors towards the direct electrical motor driven compressors (50-60 Hz) was not performed for CO2 compressors before the revival introduced by Gustav Lorentzen in the 90is of last century. Since 1988 an enormous R & D effort has been made to further develop CO2 refrigeration technology in spite of the opposition from the chemical industry. Today CO2 refrigeration and heat pumping technologies are accepted as viable and sustainable alternatives for several applications like commercial refrigeration, transport refrigeration, vehicle air conditioning & heat pumping, domestic hot water heat pumps and industrial applications. For some applications, the current threshold to introduce R744 technology can be overcome when the system design takes into account the advantage of the thermo dynamical- and fluid properties of CO2. I.e. the system is designed for transcritical operation with all it pros and cons and takes into consideration how to minimize the losses, and to apply the normally lost expansion work. Shortcut-designs, i.e. drop in solutions, just replacing the H(C)FC refrigeration unit with an CO2 systems adapted for higher system pressures will not result in energy efficient products. CO2 systems do offer the advantage of enabling flooded evaporators supported with adapted ejector technology. These units offer high system performances at low temperature differences and show low temperature air mal-distributions across evaporators. This work gives an overview for the development possibilities for several applications during the next years. Resulting in a further market share increase of CO2 refrigeration and heat pump systems, as energy efficient alternatives to current systems not applying natural working fluids.

Stem cell technology for drug discovery and development.

PubMed

Hook, Lilian A

2012-04-01

Stem cells have enormous potential to revolutionise the drug discovery process at all stages, from target identification through to toxicology studies. Their ability to generate physiologically relevant cells in limitless supply makes them an attractive alternative to currently used recombinant cell lines or primary cells. However, realisation of the full potential of stem cells is currently hampered by the difficulty in routinely directing stem cell differentiation to reproducibly and cost effectively generate pure populations of specific cell types. In this article we discuss how stem cells have already been used in the drug discovery process and how novel technologies, particularly in relation to stem cell differentiation, can be applied to attain widespread adoption of stem cell technology by the pharmaceutical industry. Copyright © 2011 Elsevier Ltd. All rights reserved.

Foundations for offshore wind turbines.

PubMed

Byrne, B W; Houlsby, G T

2003-12-15

An important engineering challenge of today, and a vital one for the future, is to develop and harvest alternative sources of energy. This is a firm priority in the UK, with the government setting a target of 10% of electricity from renewable sources by 2010. A component central to this commitment will be to harvest electrical power from the vast energy reserves offshore, through wind turbines or current or wave power generators. The most mature of these technologies is that of wind, as much technology transfer can be gained from onshore experience. Onshore wind farms, although supplying 'green energy', tend to provoke some objections on aesthetic grounds. These objections can be countered by locating the turbines offshore, where it will also be possible to install larger capacity turbines, thus maximizing the potential of each wind farm location. This paper explores some civil-engineering problems encountered for offshore wind turbines. A critical component is the connection of the structure to the ground, and in particular how the load applied to the structure is transferred safely to the surrounding soil. We review previous work on the design of offshore foundations, and then present some simple design calculations for sizing foundations and structures appropriate to the wind-turbine problem. We examine the deficiencies in the current design approaches, and the research currently under way to overcome these deficiencies. Designs must be improved so that these alternative energy sources can compete economically with traditional energy suppliers.

In-vitro characterization of buccal iontophoresis: the case of sumatriptan succinate.

PubMed

Telò, Isabella; Tratta, Elena; Guasconi, Barbara; Nicoli, Sara; Pescina, Silvia; Govoni, Paolo; Santi, Patrizia; Padula, Cristina

2016-06-15

Buccal administration of sumatriptan succinate might be an interesting alternative to the present administration routes, due to its non-invasiveness and rapid onset of action, but because of its low permeability, a permeation enhancement strategy is required. The aim of this work was then to study, in-vitro, buccal iontophoresis of sumatriptan succinate. Permeation experiments were performed in-vitro across pig esophageal epithelium, a recently proposed model of human buccal mucosa, using vertical diffusion cells. The iontophoretic behavior of the tissue was characterized by measuring its isoelectric point (Na(+) transport number and the electroosmotic flow of acetaminophen determination) and by evaluating tissue integrity after current application. The results obtained confirm the usefulness of pig esophageal epithelium as an in-vitro model membrane for buccal drug delivery. The application of iontophoresis increased sumatriptan transport, proportionally to the current density applied, without tissue damage: electrotransport was the predominant mechanism. Integrating the results of the present work with literature data on the transport of other molecules across the buccal mucosa and across the skin, we can draw a general conclusion: the difference in passive transport across buccal mucosa and across the skin is influenced by permeant lipophilicity and by the penetration pathway. Finally, buccal iontophoretic administration of sumatriptan allows to administer 6mg of the drug in 1h, representing a promising alternative to the current administration routes. Copyright © 2016 Elsevier B.V. All rights reserved.

Bimodal electric tissue ablation (BETA) - in-vivo evaluation of the effect of applying direct current before and during radiofrequency ablation of porcine liver.

PubMed

Cockburn, J F; Maddern, G J; Wemyss-Holden, S A

2007-03-01

To examine the effect of applying increasing amounts of direct current (DC) before and during alternating current radiofrequency ablation of porcine liver. Using a Radiotherapeutics RF3000 generator, a 9 V AC/DC transformer and a 16 G plain aluminium tube as an electrode, a control group of 24 porcine hepatic radiofrequency ablation zones was compared with 24 zones created using a bimodal electric tissue ablation (BETA) technique in three pigs. All ablations were terminated when tissue impedance rose to greater than 999 Omega or radiofrequency energy input fell below 5 W on three successive measurements taken at 1 min intervals. BETA ablations were performed in two phases: an initial phase of variable duration DC followed by a second phase during which standard radiofrequency ablation was applied simultaneously with DC. During this second phase, radiofrequency power input was regulated by the feedback circuitry of the RF3000 generator according to changes in tissue impedance. The diameters (mm) of each ablation zone were measured by two observers in two planes perpendicular to the plane of needle insertion. The mean short axis diameter of each ablation zone was subjected to statistical analysis. With increased duration of prior application of DC, there was a progressive increase in the diameter of the ablation zone (p<0.001). This effect increased sharply up to 300 s of pre-treatment after which a further increase in diameter occurred, but at a much lesser rate. A maximum ablation zone diameter of 32 mm was produced (control diameters 10-13 mm). Applying a 9 V DC to porcine liver in vivo, and continuing this DC application during subsequent radiofrequency ablation, results in larger ablation zone diameters compared with radiofrequency ablation alone.

Noncontingent reinforcement, alternative reinforcement, and the matching law: a laboratory demonstration.

PubMed Central

Ecott, Cheryl L; Critchfield, Thomas S

2004-01-01

Basic researchers, but not most applied researchers, have assumed that the behavior-decelerating effects of noncontingent reinforcement result at least partly from adventitious reinforcement of competing behaviors. The literature contains only sketchy evidence of these effects because few noncontingent reinforcement studies measure alternative behaviors. A laboratory model is presented in which concurrent schedules of contingent reinforcement were used to establish a "target" and an "alternative" behavior. Imposing noncontingent reinforcement decreased target behavior rates and increased alternative behavior rates, outcomes that were well described by the standard quantitative account of alternative reinforcement, the generalized matching law. These results suggest that adventitious reinforcement of alternative behaviors can occur during noncontingent reinforcement interventions, although the range of conditions under which this occurs remains to be determined in future studies. As an adjunct to applied studies, laboratory models permit easy measurement of alternative behaviors and parametric manipulations needed to answer many research questions. PMID:15529885

A survey of stakeholder organisations on the proposed new European chemical policy.

PubMed

Dandrea, Jennifer; Combes, Robert

2006-03-01

In February 2001, the European Commission published a White Paper proposing that a single new system of chemical regulation should be applied throughout the Member States of the European Union. The proposed Registration, Evaluation and Authorisation of Chemicals (REACH) system was to include both new and existing chemicals, with the aim of ensuring that sufficient pertinent data were made available to enable human health and the environment to be protected. The policy was founded on the principle of sustainable industrial development, and ambitiously attempted to incorporate the needs and views of key stakeholder organisations, such as industry, trade associations, consumer groups, environmentalists, animal welfarists and Member State governments. During the period between the publication of the White Paper and the on-line publication of consultation documents, as part of a public consultation exercise, in May 2003, many of these key stakeholder organisations produced material in support of or critical of the White Paper, either in part or as a whole. In this paper, we have attempted to review this extensive material and to present it in the context of the current chemical regulatory system that the REACH system will replace. Emphasis is placed on the impact of the new policy on the number of animals used in the testing regimes within the REACH system and the inclusion of alternative methods into the legislation. Although supportive of the overriding aims of the new policy, FRAME believes that the fundamental concept of a risk-free environment is flawed, and that the new REACH system will involve the unjustifiable use of millions of laboratory animals. The new policy does include alternative methods, particularly for base set substances. Nevertheless, alternative testing methods that are already available have been excluded and replaced with outdated in vivo versions. There is also insufficient detail with regard to the further development and validation of alternative methods, particularly for substances of high concern, such as endocrine disrupters or reproductive toxins, for which no alternative testing methods currently exist.

A survey of stakeholder organisations on the proposed new European chemicals policy.

PubMed

Dandrea, Jennifer; Combes, Robert D

2003-11-01

In February 2001, the European Commission published a White Paper proposing that a single new system of chemical regulation should be applied throughout the Member States of the European Union. The proposed Registration, Evaluation and Authorisation of Chemicals (REACH) system was to include both new and existing chemicals, with the aim of ensuring that sufficient pertinent data were made available to enable human health and the environment to be protected. The policy was founded on the principle of sustainable industrial development, and ambitiously attempted to incorporate the needs and views of key stakeholder organisations, such as industry, trade associations, consumer groups, environmentalists, animal welfarists and Member State governments. During the period between the publication of the White Paper and the on-line publication of consultation documents, as part of a public consultation exercise, in May 2003, many of these key stakeholder organisations produced material in support of or critical of the White Paper, either in part or as a whole. In this paper, we have attempted to review this extensive material and to present it in the context of the current chemical regulatory system that the REACH system will replace. Emphasis is placed on the impact of the new policy on the number of animals used in the testing regimes within the REACH system and the inclusion of alternative methods into the legislation. Although supportive of the overriding aims of the new policy, FRAME believes that the fundamental concept of a risk-free environment is flawed, and that the new REACH system will involve the unjustifiable use of millions of laboratory animals. The new policy does include alternative methods, particularly for base-set substances. Nevertheless, alternative testing methods that are already available have been excluded and replaced with outdated in vivo versions. There is also insufficient detail with regard to the further development and validation of alternative methods, particularly for substances of high concern, such as endocrine disrupters or reproductive toxins, for which no alternative testing methods currently exist.

Report: landfill alternative daily cover: conserving air space and reducing landfill operating cost.

PubMed

Haughey, R D

2001-02-01

Title 40, Part 258 of the Code of Federal Regulations, Solid Waste Disposal Facility Criteria, commonly referred to as Subtitle D, became effective on October 9, 1993. It establishes minimum criteria for solid waste disposal facility siting, design, operations, groundwater monitoring and corrective action, and closure and postclosure maintenance, while providing EPA-approved state solid waste regulatory programs flexibility in implementing the criteria. Section 258.21(a) [40 CFR 258.21(a)] requires owners or operators of municipal solid waste landfill (MSWLF) units to cover disposed solid waste with 30cm of earthen material at the end of the operating day, or at more frequent intervals, if necessary, to control disease vectors, fires, odours, blowing litter, and scavenging. This requirement is consistent with already existing solid waste facility regulations in many states. For many MSWLFs, applying daily cover requires the importation of soil which increases landfill operating costs. Daily cover also uses valuable landfill air space, reducing potential operating revenue and the landfill's operating life. 40 CFR 258.21 (b) allows the director of an approved state to approve alternative materials of an alternative thickness if the owner or operator demonstrates that the alternative material and thickness will control disease vectors, fires, odours, blowing litter, and scavenging without presenting a threat to human health and the environment. Many different types of alternative daily cover (ADC) are currently being used, including geosynthetic tarps, foams, garden waste, and auto shredder fluff. These materials use less air space than soil and can reduce operating costs. This paper discusses the variety of ADCs currently being used around the country and their applicability to different climates and operating conditions, highlighting the more unusual types of ADC, the types of demonstrations necessary to obtain approval of ADC, and the impact on landfill air space and operating costs of ADC use.

In search of robust flood risk management alternatives for the Netherlands

NASA Astrophysics Data System (ADS)

Klijn, F.; Knoop, J. M.; Ligtvoet, W.; Mens, M. J. P.

2012-05-01

The Netherlands' policy for flood risk management is being revised in view of a sustainable development against a background of climate change, sea level rise and increasing socio-economic vulnerability to floods. This calls for a thorough policy analysis, which can only be adequate when there is agreement about the "framing" of the problem and about the strategic alternatives that should be taken into account. In support of this framing, we performed an exploratory policy analysis, applying future climate and socio-economic scenarios to account for the autonomous development of flood risks, and defined a number of different strategic alternatives for flood risk management at the national level. These alternatives, ranging from flood protection by brute force to reduction of the vulnerability by spatial planning only, were compared with continuation of the current policy on a number of criteria, comprising costs, the reduction of fatality risk and economic risk, and their robustness in relation to uncertainties. We found that a change of policy away from conventional embankments towards gaining control over the flooding process by making the embankments unbreachable is attractive. By thus influencing exposure to flooding, the fatality risk can be effectively reduced at even lower net societal costs than by continuation of the present policy or by raising the protection standards where cost-effective.

Antitumor effects of electrochemical treatment

PubMed Central

González, Maraelys Morales; Zamora, Lisset Ortíz; Cabrales, Luis Enrique Bergues; Sierra González, Gustavo Victoriano; de Oliveira, Luciana Oliveira; Zanella, Rodrigo; Buzaid, Antonio Carlos; Parise, Orlando; Brito, Luciana Macedo; Teixeira, Cesar Augusto Antunes; Gomes, Marina das Neves; Moreno, Gleyce; Feo da Veiga, Venicio; Telló, Marcos; Holandino, Carla

2013-01-01

Electrochemical treatment is an alternative modality for tumor treatment based on the application of a low intensity direct electric current to the tumor tissue through two or more platinum electrodes placed within the tumor zone or in the surrounding areas. This treatment is noted for its great effectiveness, minimal invasiveness and local effect. Several studies have been conducted worldwide to evaluate the antitumoral effect of this therapy. In all these studies a variety of biochemical and physiological responses of tumors to the applied treatment have been obtained. By this reason, researchers have suggested various mechanisms to explain how direct electric current destroys tumor cells. Although, it is generally accepted this treatment induces electrolysis, electroosmosis and electroporation in tumoral tissues. However, action mechanism of this alternative modality on the tumor tissue is not well understood. Although the principle of Electrochemical treatment is simple, a standardized method is not yet available. The mechanism by which Electrochemical treatment affects tumor growth and survival may represent more complex process. The present work analyzes the latest and most important research done on the electrochemical treatment of tumors. We conclude with our point of view about the destruction mechanism features of this alternative therapy. Also, we suggest some mechanisms and strategies from the thermodynamic point of view for this therapy. In the area of Electrochemical treatment of cancer this tool has been exploited very little and much work remains to be done. Electrochemical treatment constitutes a good therapeutic option for patients that have failed the conventional oncology methods. PMID:23592904

26 CFR 1.6655-3 - Adjusted seasonal installment method.

Code of Federal Regulations, 2010 CFR

2010-04-01

... TAX (CONTINUED) INCOME TAXES Additions to the Tax, Additional Amounts, and Assessable Penalties § 1... under § 1.6655-2 apply to the computation of taxable income (and resulting tax) for purposes of... applying to alternative minimum taxable income, tentative minimum tax, and alternative minimum tax, the...

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function.

PubMed

Curado, Marco; Fritsch, Brita; Reis, Janine

2016-02-04

Non-invasive electrical brain stimulation (NEBS) is used to modulate brain function and behavior, both for research and clinical purposes. In particular, NEBS can be applied transcranially either as direct current stimulation (tDCS) or alternating current stimulation (tACS). These stimulation types exert time-, dose- and in the case of tDCS polarity-specific effects on motor function and skill learning in healthy subjects. Lately, tDCS has been used to augment the therapy of motor disabilities in patients with stroke or movement disorders. This article provides a step-by-step protocol for targeting the primary motor cortex with tDCS and transcranial random noise stimulation (tRNS), a specific form of tACS using an electrical current applied randomly within a pre-defined frequency range. The setup of two different stimulation montages is explained. In both montages the emitting electrode (the anode for tDCS) is placed on the primary motor cortex of interest. For unilateral motor cortex stimulation the receiving electrode is placed on the contralateral forehead while for bilateral motor cortex stimulation the receiving electrode is placed on the opposite primary motor cortex. The advantages and disadvantages of each montage for the modulation of cortical excitability and motor function including learning are discussed, as well as safety, tolerability and blinding aspects.

Multiwalled carbon nanotubes for stray light suppression in space flight instruments

NASA Astrophysics Data System (ADS)

Hagopian, John G.; Getty, Stephanie A.; Quijada, Manuel; Tveekrem, June; Shiri, Ron; Roman, Patrick; Butler, James; Georgiev, Georgi; Livas, Jeff; Hunt, Cleophus; Maldonado, Alejandro; Talapatra, Saikat; Zhang, Xianfeng; Papadakis, Stergios J.; Monica, Andrew H.; Deglau, David

2010-08-01

Observations of the Earth are extremely challenging; its large angular extent floods scientific instruments with high flux within and adjacent to the desired field of view. This bright light diffracts from instrument structures, rattles around and invariably contaminates measurements. Astrophysical observations also are impacted by stray light that obscures very dim objects and degrades signal to noise in spectroscopic measurements. Stray light is controlled by utilizing low reflectance structural surface treatments and by using baffles and stops to limit this background noise. In 2007 GSFC researchers discovered that Multiwalled Carbon Nanotubes (MWCNTs) are exceptionally good absorbers, with potential to provide order-of-magnitude improvement over current surface treatments and a resulting factor of 10,000 reduction in stray light when applied to an entire optical train. Development of this technology will provide numerous benefits including: a.) simplification of instrument stray light controls to achieve equivalent performance, b.) increasing observational efficiencies by recovering currently unusable scenes in high contrast regions, and c.) enabling low-noise observations that are beyond current capabilities. Our objective was to develop and apply MWCNTs to instrument components to realize these benefits. We have addressed the technical challenges to advance the technology by tuning the MWCNT geometry using a variety of methods to provide a factor of 10 improvement over current surface treatments used in space flight hardware. Techniques are being developed to apply the optimized geometry to typical instrument components such as spiders, baffles and tubes. Application of the nanostructures to alternate materials (or by contact transfer) is also being investigated. In addition, candidate geometries have been tested and optimized for robustness to survive integration, testing, launch and operations associated with space flight hardware. The benefits of this technology extend to space science where observations of extremely dim objects require suppression of stray light.

Balancing research and funding using value of information and portfolio tools for nanomaterial risk classification

NASA Astrophysics Data System (ADS)

Bates, Matthew E.; Keisler, Jeffrey M.; Zussblatt, Niels P.; Plourde, Kenton J.; Wender, Ben A.; Linkov, Igor

2016-02-01

Risk research for nanomaterials is currently prioritized by means of expert workshops and other deliberative processes. However, analytical techniques that quantify and compare alternative research investments are increasingly recommended. Here, we apply value of information and portfolio decision analysis—methods commonly applied in financial and operations management—to prioritize risk research for multiwalled carbon nanotubes and nanoparticulate silver and titanium dioxide. We modify the widely accepted CB Nanotool hazard evaluation framework, which combines nano- and bulk-material properties into a hazard score, to operate probabilistically with uncertain inputs. Literature is reviewed to develop uncertain estimates for each input parameter, and a Monte Carlo simulation is applied to assess how different research strategies can improve hazard classification. The relative cost of each research experiment is elicited from experts, which enables identification of efficient research portfolios—combinations of experiments that lead to the greatest improvement in hazard classification at the lowest cost. Nanoparticle shape, diameter, solubility and surface reactivity were most frequently identified within efficient portfolios in our results.

Transport of ions using RF Carpets in Helium Gas

NASA Astrophysics Data System (ADS)

Lambert, Keenan; Kelly, James; Brodeur, Maxime

2017-09-01

Radio-Frequency (RF) carpet are critical components of large volume gas cells used to thermalize radioactive ion beams produced at in-flight facilities. RF carpets are formed by a series of co-centric conductive rings on which an alternating potential (in the radio-frequency range) is applied with opposite polarity on adjacent rings. This results in a strong repelling force that keep the ions a certain distance from the carpet. The transport of ions using RF carpet is accomplished using either a potential gradient applied on the individual all strips or traveling wave (using the so-called `ion surfing method'). A test setup has been constructed at the University of Notre Dame to perform studies on the repelling of ions using RF carpets. This test setup has recently been improved by the addiction of circuitry elements allowing the transport of ions using the ion surfing method. The developed circuitry, together with transport results for various ion beam currents, electric force applied on the ions, and traveling wave amplitude and speed will be presented

Biological Control of Aflatoxin Contamination in U.S. Crops and the Use of Bioplastic Formulations of Aspergillus flavus Biocontrol Strains To Optimize Application Strategies.

PubMed

Abbas, Hamed K; Accinelli, Cesare; Shier, W Thomas

2017-08-23

Aflatoxin contamination has a major economic impact on crop production in the southern United States. Reduction of aflatoxin contamination in harvested crops has been achieved by applying nonaflatoxigenic biocontrol Aspergillus flavus strains that can out-compete wild aflatoxigenic A. flavus, reducing their numbers at the site of application. Currently, the standard method for applying biocontrol A. flavus strains to soil is using a nutrient-supplying carrier (e.g., pearled barley for Afla-Guard). Granules of Bioplastic (partially acetylated corn starch) have been investigated as an alternative nutritive carrier for biocontrol agents. Bioplastic granules have also been used to prepare a sprayable biocontrol formulation that gives effective reduction of aflatoxin contamination in harvested corn kernels with application of much smaller amounts to leaves later in the growing season. The ultimate goal of biocontrol research is to produce biocontrol systems that can be applied to crops only when long-range weather forecasting indicates they will be needed.

Balancing research and funding using value of information and portfolio tools for nanomaterial risk classification.

PubMed

Bates, Matthew E; Keisler, Jeffrey M; Zussblatt, Niels P; Plourde, Kenton J; Wender, Ben A; Linkov, Igor

2016-02-01

Risk research for nanomaterials is currently prioritized by means of expert workshops and other deliberative processes. However, analytical techniques that quantify and compare alternative research investments are increasingly recommended. Here, we apply value of information and portfolio decision analysis-methods commonly applied in financial and operations management-to prioritize risk research for multiwalled carbon nanotubes and nanoparticulate silver and titanium dioxide. We modify the widely accepted CB Nanotool hazard evaluation framework, which combines nano- and bulk-material properties into a hazard score, to operate probabilistically with uncertain inputs. Literature is reviewed to develop uncertain estimates for each input parameter, and a Monte Carlo simulation is applied to assess how different research strategies can improve hazard classification. The relative cost of each research experiment is elicited from experts, which enables identification of efficient research portfolios-combinations of experiments that lead to the greatest improvement in hazard classification at the lowest cost. Nanoparticle shape, diameter, solubility and surface reactivity were most frequently identified within efficient portfolios in our results.

The application of modern methods of biomechanics to the evaluation of jumping performance in ancient Greece.

PubMed

Ward-Smith, A J

1995-06-01

Modern methods of biomechanics are applied to examine some of the outstanding feats of jumping that have been reported in the literature from classical times. It is concluded that these feats could not have been achieved using the current long-jump prescription, with the take-off and landing areas in the same horizontal plane. A possible explanation is that the landing area was some 5.5 m or more below the take-off area. Alternatively, and more plausibly, the jump could have been similar to the modern triple jump.

Digital electronic bone growth stimulator

DOEpatents

Kronberg, James W.

1995-01-01

A device for stimulating bone tissue by applying a low level alternating current signal directly to the patient's skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated to the underlying bone structures.

Biosolids management strategies: an evaluation of energy production as an alternative to land application.

PubMed

Egan, Maureen

2013-07-01

Currently, more than half of the biosolids produced within the USA are land applied. Land application of biosolids introduces organic contaminants into the environment. There are potential ecological and human health risks associated with land application of biosolids. Biosolids may be used as a renewable energy source. Nutrients may be recovered from biosolids used for energy generation for use as fertilizer. The by-products of biosolids energy generation may be used beneficially in construction materials. It is recommended that energy generation replace land application as the leading biosolids management strategy.

Self-oscillations in field emission nanowire mechanical resonators: a nanometric dc-ac conversion.

PubMed

Ayari, Anthony; Vincent, Pascal; Perisanu, Sorin; Choueib, May; Gouttenoire, Vincent; Bechelany, Mikhael; Cornu, David; Purcell, Stephen T

2007-08-01

We report the observation of self-oscillations in a bottom-up nanoelectromechanical system (NEMS) during field emission driven by a constant applied voltage. An electromechanical model is explored that explains the phenomenon and that can be directly used to develop integrated devices. In this first study, we have already achieved approximately 50% dc/ac (direct to alternating current) conversion. Electrical self-oscillations in NEMS open up a new path for the development of high-speed, autonomous nanoresonators and signal generators and show that field emission (FE) is a powerful tool for building new nanocomponents.

Marketing fundamentals.

PubMed

Redmond, W H

2001-01-01

This chapter outlines current marketing practice from a managerial perspective. The role of marketing within an organization is discussed in relation to efficiency and adaptation to changing environments. Fundamental terms and concepts are presented in an applied context. The implementation of marketing plans is organized around the four P's of marketing: product (or service), promotion (including advertising), place of delivery, and pricing. These are the tools with which marketers seek to better serve their clients and form the basis for competing with other organizations. Basic concepts of strategic relationship management are outlined. Lastly, alternate viewpoints on the role of advertising in healthcare markets are examined.

The novel phage-derived antimicrobial agent HY-133 is active against livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA).

PubMed

Kaspar, Ursula; de Haro Sautto, Jorge A; Molinaro, Sonja; Peters, Georg; Idelevich, Evgeny A; Becker, Karsten

2018-05-07

Livestock-associated, methicillin-resistant Staphylococcus aureus (LA-MRSA) are increasingly migrating from livestock into human and animal health care settings. Alternative substances are wanted to overcome the drawbacks of currently available drugs applied for MRSA eradication. The recombinant bacteriophage endolysin HY-133 has been proven as an active agent against S. aureus Here, the in vitro activity of HY-133 was studied against a large collection of genetically diverse LA-MRSA revealing its high activity against mecA, mecB and mecC LA-MRSA. Copyright © 2018 American Society for Microbiology.

SpeCond: a method to detect condition-specific gene expression

PubMed Central

2011-01-01

Transcriptomic studies routinely measure expression levels across numerous conditions. These datasets allow identification of genes that are specifically expressed in a small number of conditions. However, there are currently no statistically robust methods for identifying such genes. Here we present SpeCond, a method to detect condition-specific genes that outperforms alternative approaches. We apply the method to a dataset of 32 human tissues to determine 2,673 specifically expressed genes. An implementation of SpeCond is freely available as a Bioconductor package at http://www.bioconductor.org/packages/release/bioc/html/SpeCond.html. PMID:22008066

In Defense of P Values

PubMed Central

Verhulst, Brad

2016-01-01

P values have become the scapegoat for a wide variety of problems in science. P values are generally over-emphasized, often incorrectly applied, and in some cases even abused. However, alternative methods of hypothesis testing will likely fall victim to the same criticisms currently leveled at P values if more fundamental changes are not made in the research process. Increasing the general level of statistical literacy and enhancing training in statistical methods provide a potential avenue for identifying, correcting, and preventing erroneous conclusions from entering the academic literature and for improving the general quality of patient care. PMID:28366961

77 FR 16212 - Availability of Seats for the Channel Islands National Marine Sanctuary Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-20

...: Recreational Fishing member and alternate, Tourism member and alternate, Education member and alternate... applying; community and professional affiliations; philosophy regarding the protection and management of...

40 CFR 65.102 - Alternative means of emission limitation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks § 65.102 Alternative means of emission... equipment leaks of a regulated material may apply to the Administrator for approval of an alternative means...

3 CFR - Demonstration Grants for the Development, Implementation, and Evaluation of Alternatives to the...

Code of Federal Regulations, 2010 CFR

2010-01-01

..., Implementation, and Evaluation of Alternatives to the Current Medical Liability System Presidential Documents..., Implementation, and Evaluation of Alternatives to the Current Medical Liability System Memorandum for the... report that fear of lawsuits leads them to practice defensive medicine, which may contribute to higher...

Apparatus and method for critical current measurements

DOEpatents

Martin, Joe A.; Dye, Robert C.

1992-01-01

An apparatus for the measurement of the critical current of a superconductive sample, e.g., a clad superconductive sample, the apparatus including a conductive coil, a means for maintaining the coil in proximity to a superconductive sample, an electrical connection means for passing a low amplitude alternating current through the coil, a cooling means for maintaining the superconductive sample at a preselected temperature, a means for passing a current through the superconductive sample, and, a means for monitoring reactance of the coil, is disclosed, together with a process of measuring the critical current of a superconductive material, e.g., a clad superconductive material, by placing a superconductive material into the vicinity of the conductive coil of such an apparatus, cooling the superconductive material to a preselected temperature, passing a low amplitude alternating current through the coil, the alternating current capable of generating a magnetic field sufficient to penetrate, e.g., any cladding, and to induce eddy currents in the superconductive material, passing a steadily increasing current through the superconductive material, the current characterized as having a different frequency than the alternating current, and, monitoring the reactance of the coil with a phase sensitive detector as the current passed through the superconductive material is steadily increased whereby critical current of the superconductive material can be observed as the point whereat a component of impedance deviates.

49 CFR 236.2 - Grounds.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., single-break, signal control circuits using a grounded common, and alternating current power distribution...) Alternating current power distribution circuits that are grounded in the interest of safety. ...

Discrete-event system simulation on small and medium enterprises productivity improvement

NASA Astrophysics Data System (ADS)

Sulistio, J.; Hidayah, N. A.

2017-12-01

Small and medium industries in Indonesia is currently developing. The problem faced by SMEs is the difficulty of meeting growing demand coming into the company. Therefore, SME need an analysis and evaluation on its production process in order to meet all orders. The purpose of this research is to increase the productivity of SMEs production floor by applying discrete-event system simulation. This method preferred because it can solve complex problems die to the dynamic and stochastic nature of the system. To increase the credibility of the simulation, model validated by cooperating the average of two trials, two trials of variance and chi square test. Afterwards, Benferroni method applied to development several alternatives. The article concludes that, the productivity of SMEs production floor increased up to 50% by adding the capacity of dyeing and drying machines.

Electrochemical advanced oxidation processes as decentralized water treatment technologies to remediate domestic washing machine effluents.

PubMed

Dos Santos, Alexsandro Jhones; Costa, Emily Cintia Tossi de Araújo; da Silva, Djalma Ribeiro; Garcia-Segura, Sergi; Martínez-Huitle, Carlos Alberto

2018-03-01

Water scarcity is one of the major concerns worldwide. In order to secure this appreciated natural resource, management and development of water treatment technologies are mandatory. One feasible alternative is the consideration of water recycling/reuse at the household scale. Here, the treatment of actual washing machine effluent by electrochemical advanced oxidation processes was considered. Electrochemical oxidation and electro-Fenton technologies can be applied as decentralized small-scale water treatment devices. Therefore, efficient decolorization and total organic abatement have been followed. The results demonstrate the promising performance of solar photoelectro-Fenton process, where complete color and organic removal was attained after 240 min of treatment under optimum conditions by applying a current density of 66.6 mA cm -2 . Thus, electrochemical technologies emerge as promising water-sustainable approaches.

A dynamic gain equalizer based on holographic polymer dispersed liquid crystal gratings

NASA Astrophysics Data System (ADS)

Xin, Zhaohui; Cai, Jiguang; Shen, Guotu; Yang, Baocheng; Zheng, Jihong; Gu, Lingjuan; Zhuang, Songlin

2006-12-01

The dynamic gain equalizer consisting of gratings made of holographic polymer dispersed liquid crystal is explored and the structure and principle presented. The properties of the holographic polymer dispersed liquid crystal grating are analyzed in light of the rigorous coupled-wave theory. Experimental study is also conducted in which a beam of infrared laser was incident to the grating sample and an alternating current electric field applied. The electro-optical properties of the grating and the influence of the applied field were observed. The results of the experiment agree with that of the theory quite well. The design method of the dynamic gain equalizer with the help of numerical simulation is presented too. The study shows that holographic polymer dispersed liquid crystal gratings have great potential to play a role in fiber optics communication.

Using population models to evaluate management alternatives for Gulf Striped Bass

USGS Publications Warehouse

Aspinwall, Alexander P.; Irwin, Elise R.; Lloyd, M. Clint

2017-01-01

Interstate management of Gulf Striped Bass Morone saxatilis has involved a thirty-year cooperative effort involving Federal and State agencies in Georgia, Florida and Alabama (Apalachicola-Chattahoochee-Flint Gulf Striped Bass Technical Committee). The Committee has recently focused on developing an adaptive framework for conserving and restoring Gulf Striped Bass in the Apalachicola, Chattahoochee, and Flint River (ACF) system. To evaluate the consequences and tradeoffs among management activities, population models were used to inform management decisions. Stochastic matrix models were constructed with varying recruitment and stocking rates to simulate effects of management alternatives on Gulf Striped Bass population objectives. An age-classified matrix model that incorporated stock fecundity estimates and survival estimates was used to project population growth rate. In addition, combinations of management alternatives (stocking rates, Hydrilla control, harvest regulations) were evaluated with respect to how they influenced Gulf Striped Bass population growth. Annual survival and mortality rates were estimated from catch-curve analysis, while fecundity was estimated and predicted using a linear least squares regression analysis of fish length versus egg number from hatchery brood fish data. Stocking rates and stocked-fish survival rates were estimated from census data. Results indicated that management alternatives could be an effective approach to increasing the Gulf Striped Bass population. Population abundance was greatest under maximum stocking effort, maximum Hydrilla control and a moratorium. Conversely, population abundance was lowest under no stocking, no Hydrilla control and the current harvest regulation. Stocking rates proved to be an effective management strategy; however, low survival estimates of stocked fish (1%) limited the potential for population growth. Hydrilla control increased the survival rate of stocked fish and provided higher estimates of population abundances than maximizing the stocking rate. A change in the current harvest regulation (50% harvest regulation) was not an effective alternative to increasing the Gulf Striped Bass population size. Applying a moratorium to the Gulf Striped Bass fishery increased survival rates from 50% to 74% and resulted in the largest population growth of the individual management alternatives. These results could be used by the Committee to inform management decisions for other populations of Striped Bass in the Gulf Region.

26 CFR 20.2032-1 - Alternate valuation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... alternate valuation method under section 2032, the property included in the decedent's gross estate on the..., the alternate valuation method applies to all property included in the gross estate and cannot be... elects the alternate valuation method under section 2432, all property interests existing at the date of...

40 CFR 63.7747 - How do I apply for alternative monitoring requirements for a continuous emissions monitoring system?

Code of Federal Regulations, 2011 CFR

2011-07-01

... monitoring requirements for a continuous emissions monitoring system? 63.7747 Section 63.7747 Protection of... apply for alternative monitoring requirements for a continuous emissions monitoring system? (a) You may... prevention technique, a description of the continuous monitoring system or method including appropriate...

40 CFR 63.7747 - How do I apply for alternative monitoring requirements for a continuous emissions monitoring system?

Code of Federal Regulations, 2010 CFR

2010-07-01

... monitoring requirements for a continuous emissions monitoring system? 63.7747 Section 63.7747 Protection of... apply for alternative monitoring requirements for a continuous emissions monitoring system? (a) You may... prevention technique, a description of the continuous monitoring system or method including appropriate...

Efficient C1-continuous phase-potential upwind (C1-PPU) schemes for coupled multiphase flow and transport with gravity

NASA Astrophysics Data System (ADS)

Jiang, Jiamin; Younis, Rami M.

2017-10-01

In the presence of counter-current flow, nonlinear convergence problems may arise in implicit time-stepping when the popular phase-potential upwinding (PPU) scheme is used. The PPU numerical flux is non-differentiable across the co-current/counter-current flow regimes. This may lead to cycles or divergence in the Newton iterations. Recently proposed methods address improved smoothness of the numerical flux. The objective of this work is to devise and analyze an alternative numerical flux scheme called C1-PPU that, in addition to improving smoothness with respect to saturations and phase potentials, also improves the level of scalar nonlinearity and accuracy. C1-PPU involves a novel use of the flux limiter concept from the context of high-resolution methods, and allows a smooth variation between the co-current/counter-current flow regimes. The scheme is general and applies to fully coupled flow and transport formulations with an arbitrary number of phases. We analyze the consistency property of the C1-PPU scheme, and derive saturation and pressure estimates, which are used to prove the solution existence. Several numerical examples for two- and three-phase flows in heterogeneous and multi-dimensional reservoirs are presented. The proposed scheme is compared to the conventional PPU and the recently proposed Hybrid Upwinding schemes. We investigate three properties of these numerical fluxes: smoothness, nonlinearity, and accuracy. The results indicate that in addition to smoothness, nonlinearity may also be critical for convergence behavior and thus needs to be considered in the design of an efficient numerical flux scheme. Moreover, the numerical examples show that the C1-PPU scheme exhibits superior convergence properties for large time steps compared to the other alternatives.

Test Results for Rotordynamic Coefficients of the SSME HPOTP Turbine Interstage Seal with Two Swirl Brakes

NASA Technical Reports Server (NTRS)

Childs, Dara W.; Baskharone, Erian; Ramsey, Christopher

1991-01-01

Test results are presented for the HPOTP Turbine Interstage Seal with both the current and an alternate, aerodynamically designed, swirl brake. Tests were conducted at speeds out to 16,000 rpm, supply pressures up to 18.3 bars, and the following three inlet tangential velocity conditions: (1) no preswirl; (2) intermediate preswirl in the direction of rotation; and (3) high preswirl in the direction of rotation. The back pressure can be controlled independently and was varied to yield the following four pressure ratios: 0.4, 0.45, 0.56, and 0.67. The central and simplest conclusion to be obtained from the test series is that the alternate swirl brake consistently outperforms the current swirl brake in terms of stability performance. The alternate swirl brake's whirl frequency ratio was generally about one half or less than corresponding values for the current design. In many cases, the alternate design yielded negative whirl frequency ratio values in comparison to positive values for the current design. The alternate design can be directly substituted into the space currently occupied by the current design. There is no change in leakage performance.

Cost-Benefit Analysis for Alternatives to Aliphatic Isocyanate Polyurethanes

NASA Technical Reports Server (NTRS)

Lewis, Pattie

2007-01-01

NASA and Air Force Space Command (AFSPC) have similar missions and therefore similar facilities and structures in similar environments. The standard practice for protecting metallic substrates in atmospheric environments is the application of an applied coating system. The most common topcoats used in coating systems are polyurethanes that contain isocyanates. Isocyanates are classified as potential human carcinogens and are known to cause cancer in animals. The primary objective of this effort was to demonstrate and validate alternatives to aliphatic isocyanate polyurethanes resulting in one or more isocyanate-free coatings qualified for use at AFSPC and NASA installations participating in this project. This Cost-Benefit Analysis (CBA) quantifies the estimated capital and process costs of coating alternatives and cost savings relative to the current coatings. The estimates in this CBA are to be used for assessing the relative merits of the selected alternatives. The actual economic effects at any specific facility will depend on the alternative material or technology implemented, the number of actual applications converted, future workloads, and other factors . The participants initially considered eighteen (18) alternative coatings as described in the Potential Alternatives Report entitled Potential Alternatives Report for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes, prepared by ITB. Of those, 8 alternatives were selected for testing in accordance with the Joint Test Protocol entitled Joint Test Protocol for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes, and the Field Test Plan entitled Field Evaluations Test Plan for Validation of Alternatives 10 Aliphatic Isocyanate Polyurethanes, both of which were prepared by ITB. A joint Test Report entitled Joint Test Report for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes, prepared by ITB, documents the results of the laboratory and field testing, as well as any test modifications made during the execution of the testing. The coatings selected for evaluation in this CBA are shown in the table below. Only one control coating system is considered in this analysis. These coatings were either downselected for Phase II or performed well enough to be included in the Qualified Products List in the NASA technical standard NASA-STD-5008, Protective Coating of Carbon Steel, Stainless Steel, and Aluminum on Launch Structures, Facilities, and Ground Support Equipment.

Ion manipulation device to prevent loss of ions

DOEpatents

Tolmachev, Aleksey; Smith, Richard D; Ibrahim, Yehia M; Anderson, Gordon A; Baker, Erin M

2015-03-03

An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.

Development of a phosphorus index for pastures fertilized with poultry litter--factors affecting phosphorus runoff.

PubMed

DeLaune, Paul B; Moore, Philip A; Carman, Dennis K; Sharpley, Andrew N; Haggard, Brian E; Daniel, Tommy C

2004-01-01

Currently, several state and federal agencies are proposing upper limits on soil test phosphorus (P), above which animal manures cannot be applied, based on the assumption that high P concentrations in runoff are due to high soil test P. Recent studies show that other factors are more indicative of P concentrations in runoff from areas where manure is being applied. The original P index was developed as an alternative P management tool incorporating factors affecting both the source and transport of P. The objective of this research was to evaluate the effects of multiple variables on P concentrations in runoff water and to construct a P source component of a P index for pastures that incorporates these effects. The evaluated variables were: (i) soil test P, (ii) soluble P in poultry litter, (iii) P in poultry diets, (iv) fertilizer type, and (v) poultry litter application rate. Field studies with simulated rainfall showed that P runoff was affected by the amount of soluble P applied in the fertilizer source. Before manure applications, soil test P was directly related to soluble P concentrations in runoff water. However, soil test P had little effect on P runoff after animal manure was applied. Unlike most other P indices, weighting factors of the P source components in the P index for pastures are based on results from runoff studies conducted under various management scenarios. As a result, weighting factors for the P source potential variables are well justified. A modification of the P index using scientific data should strengthen the ability of the P index concept to evaluate locations and management alternatives for P losses.

Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki)

PubMed Central

2013-01-01

Background The production of multiple transcript isoforms from one gene is a major source of transcriptome complexity. RNA-Seq experiments, in which transcripts are converted to cDNA and sequenced, allow the resolution and quantification of alternative transcript isoforms. However, methods to analyze splicing are underdeveloped and errors resulting in incorrect splicing calls occur in every experiment. Results We used RNA-Seq data to develop sequencing and aligner error models. By applying these error models to known input from simulations, we found that errors result from false alignment to minor splice motifs and antisense stands, shifted junction positions, paralog joining, and repeat induced gaps. By using a series of quantitative and qualitative filters, we eliminated diagnosed errors in the simulation, and applied this to RNA-Seq data from Drosophila melanogaster heads. We used high-confidence junction detections to specifically interrogate local splicing differences between transcripts. This method out-performed commonly used RNA-seq methods to identify known alternative splicing events in the Drosophila sex determination pathway. We describe a flexible software package to perform these tasks called Splicing Analysis Kit (Spanki), available at http://www.cbcb.umd.edu/software/spanki. Conclusions Splice-junction centric analysis of RNA-Seq data provides advantages in specificity for detection of alternative splicing. Our software provides tools to better understand error profiles in RNA-Seq data and improve inference from this new technology. The splice-junction centric approach that this software enables will provide more accurate estimates of differentially regulated splicing than current tools. PMID:24209455

Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki).

PubMed

Sturgill, David; Malone, John H; Sun, Xia; Smith, Harold E; Rabinow, Leonard; Samson, Marie-Laure; Oliver, Brian

2013-11-09

The production of multiple transcript isoforms from one gene is a major source of transcriptome complexity. RNA-Seq experiments, in which transcripts are converted to cDNA and sequenced, allow the resolution and quantification of alternative transcript isoforms. However, methods to analyze splicing are underdeveloped and errors resulting in incorrect splicing calls occur in every experiment. We used RNA-Seq data to develop sequencing and aligner error models. By applying these error models to known input from simulations, we found that errors result from false alignment to minor splice motifs and antisense stands, shifted junction positions, paralog joining, and repeat induced gaps. By using a series of quantitative and qualitative filters, we eliminated diagnosed errors in the simulation, and applied this to RNA-Seq data from Drosophila melanogaster heads. We used high-confidence junction detections to specifically interrogate local splicing differences between transcripts. This method out-performed commonly used RNA-seq methods to identify known alternative splicing events in the Drosophila sex determination pathway. We describe a flexible software package to perform these tasks called Splicing Analysis Kit (Spanki), available at http://www.cbcb.umd.edu/software/spanki. Splice-junction centric analysis of RNA-Seq data provides advantages in specificity for detection of alternative splicing. Our software provides tools to better understand error profiles in RNA-Seq data and improve inference from this new technology. The splice-junction centric approach that this software enables will provide more accurate estimates of differentially regulated splicing than current tools.

Current Faculty Development Practices for Alternative Delivery Systems in Christian Higher Education Institutions: A Qualitative Study

ERIC Educational Resources Information Center

Yates, Steven Lowell

2009-01-01

This research study was an investigation of current faculty development practices for alternative delivery systems. Attention was given to faculty development in general as well as specific facets of faculty development for alternative delivery systems. Future or intended faculty development practices were pursued, along with factors that…

49 CFR 234.213 - Grounds.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: circuits that include track rail; alternating current power distribution circuits that are grounded in the...) Circuits that include track rail; (2) Alternating current power distribution circuits that are grounded in...

40 CFR 372.27 - Alternate threshold and certification.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 29 2013-07-01 2013-07-01 false Alternate threshold and certification...-TO-KNOW Reporting Requirements § 372.27 Alternate threshold and certification. (a) Except as provided... toxic chemical, the owner or operator of a facility may apply an alternate threshold of 1 million pounds...

Low-Level Laser Therapy in the Treatment of Recurrent Aphthous Ulcers: A Systematic Review

PubMed Central

Vale, Fernando Alves; de Almeida, Fernanda Campos Souza

2015-01-01

Recurrent aphthous ulcers (RAUs) are the most common lesion found in the oral cavity. There is no definitive cure for RAUs and current treatments are aimed at minimizing symptoms. Since low-level laser therapy (LLLT) modulates inflammatory responses, and promotes pain reduction and cellular biostimulation, LLLT can be suggested as an alternative treatment for RAUs. The literature concerning the potential of LLLT in the treatment of RAUs was evaluated. A systematic literature review identified 22 publications, of which only 2 studies were adopted. The eligibility criteria consisted of randomized controlled trials (RCTs). Both RCTs achieved significant results concerning LLLT and pain-level reductions and reduced healing times. Despite the variance in irradiation conditions applied in both studies, very similar wavelengths were adopted. There is accordingly strong evidence that wavelength plays an important role in RAU treatment. Taking into account the different parameters applied by selected RCTs, it is not possible to suggest that a specific protocol should be used. However, in light of the significant results found in both studies, LLLT can be suggested as an alternative for RAU treatment. Additional RCTs should be performed in order to reach a clinical protocol and better understand the application of LLLT in RAU treatment. PMID:25879049

A Particle-in-Cell Simulation for the Traveling Wave Direct Energy Converter (TWDEC) for Fusion Propulsion

NASA Technical Reports Server (NTRS)

Chap, Andrew; Tarditi, Alfonso G.; Scott, John H.

2013-01-01

A Particle-in-cell simulation model has been developed to study the physics of the Traveling Wave Direct Energy Converter (TWDEC) applied to the conversion of charged fusion products into electricity. In this model the availability of a beam of collimated fusion products is assumed; the simulation is focused on the conversion of the beam kinetic energy into alternating current (AC) electric power. The model is electrostatic, as the electro-dynamics of the relatively slow ions can be treated in the quasistatic approximation. A two-dimensional, axisymmetric (radial-axial coordinates) geometry is considered. Ion beam particles are injected on one end and travel along the axis through ring-shaped electrodes with externally applied time-varying voltages, thus modulating the beam by forming a sinusoidal pattern in the beam density. Further downstream, the modulated beam passes through another set of ring electrodes, now electrically oating. The modulated beam induces a time alternating potential di erence between adjacent electrodes. Power can be drawn from the electrodes by connecting a resistive load. As energy is dissipated in the load, a corresponding drop in beam energy is measured. The simulation encapsulates the TWDEC process by reproducing the time-dependent transfer of energy and the particle deceleration due to the electric eld phase time variations.

Novel Safranin-Tinted Candida rugosa Lipase Nanoconjugates Reagent for Visualizing Latent Fingerprints on Stainless Steel Knives Immersed in a Natural Outdoor Pond.

PubMed

Azman, Aida Rasyidah; Mahat, Naji Arafat; Abdul Wahab, Roswanira; Abdul Razak, Fazira Ilyana; Hamzah, Hafezul Helmi

2018-05-25

Waterways are popular locations for the disposition of criminal evidence because the recovery of latent fingerprints from such evidence is difficult. Currently, small particle reagent is a method often used to visualize latent fingerprints containing carcinogenic and hazardous compounds. This study proposes an eco-friendly, safranin-tinted Candida rugosa lipase (triacylglycerol ester hydrolysis EC 3.1.1.3) with functionalized carbon nanotubes (CRL-MWCNTS/GA/SAF) as an alternative reagent to the small particle reagent. The CRL-MWCNTS/GA/SAF reagent was compared with the small particle reagent to visualize groomed, full fingerprints deposited on stainless steel knives which were immersed in a natural outdoor pond for 30 days. The quality of visualized fingerprints using the new reagent was similar (modified-Centre for Applied Science and Technology grade: 4; p > 0.05) to small particle reagent, even after 15 days of immersion. Despite the slight decrease in quality of visualized fingerprints using the CRL-MWCNTS/GA/SAF on the last three immersion periods, the fingerprints remained forensically identifiable (modified-Centre for Applied Science and Technology grade: 3). The possible chemical interactions that enabled successful visualization is also discussed. Thus, this novel reagent may provide a relatively greener alternative for the visualization of latent fingerprints on immersed non-porous objects.

Fuzzy sets, rough sets, and modeling evidence: Theory and Application. A Dempster-Shafer based approach to compromise decision making with multiattributes applied to product selection

NASA Technical Reports Server (NTRS)

Dekorvin, Andre

1992-01-01

The Dempster-Shafer theory of evidence is applied to a multiattribute decision making problem whereby the decision maker (DM) must compromise with available alternatives, none of which exactly satisfies his ideal. The decision mechanism is constrained by the uncertainty inherent in the determination of the relative importance of each attribute element and the classification of existing alternatives. The classification of alternatives is addressed through expert evaluation of the degree to which each element is contained in each available alternative. The relative importance of each attribute element is determined through pairwise comparisons of the elements by the decision maker and implementation of a ratio scale quantification method. Then the 'belief' and 'plausibility' that an alternative will satisfy the decision maker's ideal are calculated and combined to rank order the available alternatives. Application to the problem of selecting computer software is given.

Reassessing the NTCTCS Staging Systems for Differentiated Thyroid Cancer, Including Age at Diagnosis

PubMed Central

McLeod, Donald S.A.; Jonklaas, Jacqueline; Brierley, James D.; Ain, Kenneth B.; Cooper, David S.; Fein, Henry G.; Haugen, Bryan R.; Ladenson, Paul W.; Magner, James; Ross, Douglas S.; Skarulis, Monica C.; Steward, David L.; Xing, Mingzhao; Litofsky, Danielle R.; Maxon, Harry R.

2015-01-01

Background: Thyroid cancer is unique for having age as a staging variable. Recently, the commonly used age cut-point of 45 years has been questioned. Objective: This study assessed alternate staging systems on the outcome of overall survival, and compared these with current National Thyroid Cancer Treatment Cooperative Study (NTCTCS) staging systems for papillary and follicular thyroid cancer. Methods: A total of 4721 patients with differentiated thyroid cancer were assessed. Five potential alternate staging systems were generated at age cut-points in five-year increments from 35 to 70 years, and tested for model discrimination (Harrell's C-statistic) and calibration (R2). The best five models for papillary and follicular cancer were further tested with bootstrap resampling and significance testing for discrimination. Results: The best five alternate papillary cancer systems had age cut-points of 45–50 years, with the highest scoring model using 50 years. No significant difference in C-statistic was found between the best alternate and current NTCTCS systems (p = 0.200). The best five alternate follicular cancer systems had age cut-points of 50–55 years, with the highest scoring model using 50 years. All five best alternate staging systems performed better compared with the current system (p = 0.003–0.035). There was no significant difference in discrimination between the best alternate system (cut-point age 50 years) and the best system of cut-point age 45 years (p = 0.197). Conclusions: No alternate papillary cancer systems assessed were significantly better than the current system. New alternate staging systems for follicular cancer appear to be better than the current NTCTCS system, although they require external validation. PMID:26203804

Likelihood-based gene annotations for gap filling and quality assessment in genome-scale metabolic models

DOE PAGES

Benedict, Matthew N.; Mundy, Michael B.; Henry, Christopher S.; ...

2014-10-16

Genome-scale metabolic models provide a powerful means to harness information from genomes to deepen biological insights. With exponentially increasing sequencing capacity, there is an enormous need for automated reconstruction techniques that can provide more accurate models in a short time frame. Current methods for automated metabolic network reconstruction rely on gene and reaction annotations to build draft metabolic networks and algorithms to fill gaps in these networks. However, automated reconstruction is hampered by database inconsistencies, incorrect annotations, and gap filling largely without considering genomic information. Here we develop an approach for applying genomic information to predict alternative functions for genesmore » and estimate their likelihoods from sequence homology. We show that computed likelihood values were significantly higher for annotations found in manually curated metabolic networks than those that were not. We then apply these alternative functional predictions to estimate reaction likelihoods, which are used in a new gap filling approach called likelihood-based gap filling to predict more genomically consistent solutions. To validate the likelihood-based gap filling approach, we applied it to models where essential pathways were removed, finding that likelihood-based gap filling identified more biologically relevant solutions than parsimony-based gap filling approaches. We also demonstrate that models gap filled using likelihood-based gap filling provide greater coverage and genomic consistency with metabolic gene functions compared to parsimony-based approaches. Interestingly, despite these findings, we found that likelihoods did not significantly affect consistency of gap filled models with Biolog and knockout lethality data. This indicates that the phenotype data alone cannot necessarily be used to discriminate between alternative solutions for gap filling and therefore, that the use of other information is necessary to obtain a more accurate network. All described workflows are implemented as part of the DOE Systems Biology Knowledgebase (KBase) and are publicly available via API or command-line web interface.« less

Likelihood-Based Gene Annotations for Gap Filling and Quality Assessment in Genome-Scale Metabolic Models

PubMed Central

Benedict, Matthew N.; Mundy, Michael B.; Henry, Christopher S.; Chia, Nicholas; Price, Nathan D.

2014-01-01

Genome-scale metabolic models provide a powerful means to harness information from genomes to deepen biological insights. With exponentially increasing sequencing capacity, there is an enormous need for automated reconstruction techniques that can provide more accurate models in a short time frame. Current methods for automated metabolic network reconstruction rely on gene and reaction annotations to build draft metabolic networks and algorithms to fill gaps in these networks. However, automated reconstruction is hampered by database inconsistencies, incorrect annotations, and gap filling largely without considering genomic information. Here we develop an approach for applying genomic information to predict alternative functions for genes and estimate their likelihoods from sequence homology. We show that computed likelihood values were significantly higher for annotations found in manually curated metabolic networks than those that were not. We then apply these alternative functional predictions to estimate reaction likelihoods, which are used in a new gap filling approach called likelihood-based gap filling to predict more genomically consistent solutions. To validate the likelihood-based gap filling approach, we applied it to models where essential pathways were removed, finding that likelihood-based gap filling identified more biologically relevant solutions than parsimony-based gap filling approaches. We also demonstrate that models gap filled using likelihood-based gap filling provide greater coverage and genomic consistency with metabolic gene functions compared to parsimony-based approaches. Interestingly, despite these findings, we found that likelihoods did not significantly affect consistency of gap filled models with Biolog and knockout lethality data. This indicates that the phenotype data alone cannot necessarily be used to discriminate between alternative solutions for gap filling and therefore, that the use of other information is necessary to obtain a more accurate network. All described workflows are implemented as part of the DOE Systems Biology Knowledgebase (KBase) and are publicly available via API or command-line web interface. PMID:25329157

Engineering paradigms and anthropogenic global change

NASA Astrophysics Data System (ADS)

Bohle, Martin

2016-04-01

This essay discusses 'paradigms' as means to conceive anthropogenic global change. Humankind alters earth-systems because of the number of people, the patterns of consumption of resources, and the alterations of environments. This process of anthropogenic global change is a composite consisting of societal (in the 'noosphere') and natural (in the 'bio-geosphere') features. Engineering intercedes these features; e.g. observing stratospheric ozone depletion has led to understanding it as a collateral artefact of a particular set of engineering choices. Beyond any specific use-case, engineering works have a common function; e.g. civil-engineering intersects economic activity and geosphere. People conceive their actions in the noosphere including giving purpose to their engineering. The 'noosphere' is the ensemble of social, cultural or political concepts ('shared subjective mental insights') of people. Among people's concepts are the paradigms how to shape environments, production systems and consumption patterns given their societal preferences. In that context, engineering is a means to implement a given development path. Four paradigms currently are distinguishable how to make anthropogenic global change happening. Among the 'engineering paradigms' for anthropogenic global change, 'adaptation' is a paradigm for a business-as-usual scenario and steady development paths of societies. Applying this paradigm implies to forecast the change to come, to appropriately design engineering works, and to maintain as far as possible the current production and consumption patterns. An alternative would be to adjust incrementally development paths of societies, namely to 'dovetail' anthropogenic and natural fluxes of matter and energy. To apply that paradigm research has to identify 'natural boundaries', how to modify production and consumption patterns, and how to tackle process in the noosphere to render alterations of common development paths acceptable. A further alternative, the paradigm of 'ecomodernism' implies to accentuate some of the current development paths of societies with the goal to 'decouple' anthropogenic and natural fluxes of matter and energy. Applying the paradigm 'geoengineering', engineering works shall 'modulate' natural fluxes of matter to counter the effect of anthropogenic fluxes of matter instead to alter the development paths of societies. Thus, anthropogenic global change is a composite process in which engineering intercedes the 'noosphere' and in the 'bio-geosphere'. Paradigms 'how to engineering earth systems' reflect different concepts ('shared subjective insights') how to combine knowledge with use, function and purpose. Currently, four paradigms are distinguishable how to engineer anthropogenic global change. They convene recipes human activity and bio-geosphere should intersect.

A novel miniature dynamic microfluidic cell culture platform using electro-osmosis diode pumping.

PubMed

Chang, Jen-Yung; Wang, Shuo; Allen, Jeffrey S; Lee, Seong Hyuk; Chang, Suk Tai; Choi, Young-Ki; Friedrich, Craig; Choi, Chang Kyoung

2014-07-01

An electro-osmosis (EOS) diode pumping platform capable of culturing cells in fluidic cellular micro-environments particularly at low volume flow rates has been developed. Diode pumps have been shown to be a viable alternative to mechanically driven pumps. Typically electrokinetic micro-pumps were limited to low-concentration solutions (≤10 mM). In our approach, surface mount diodes were embedded along the sidewalls of a microchannel to rectify externally applied alternating current into pulsed direct current power across the diodes in order to generate EOS flows. This approach has for the first time generated flows at ultra-low flow rates (from 2.0 nl/s to 12.3 nl/s) in aqueous solutions with concentrations greater than 100 mM. The range of flow was generated by changing the electric field strength applied to the diodes from 0.5 Vpp/cm to 10 Vpp/cm. Embedding an additional diode on the upper surface of the enclosed microchannel increased flow rates further. We characterized the diode pump-driven fluidics in terms of intensities and frequencies of electric inputs, pH values of solutions, and solution types. As part of this study, we found that the growth of A549 human lung cancer cells was positively affected in the microfluidic diode pumping system. Though the chemical reaction compromised the fluidic control overtime, the system could be maintained fully functional over a long time if the solution was changed every hour. In conclusion, the advantage of miniature size and ability to accurately control fluids at ultra-low volume flow rates can make this diode pumping system attractive to lab-on-a-chip applications and biomedical engineering in vitro studies.

A novel miniature dynamic microfluidic cell culture platform using electro-osmosis diode pumping

PubMed Central

Chang, Jen-Yung; Wang, Shuo; Allen, Jeffrey S.; Lee, Seong Hyuk; Chang, Suk Tai; Choi, Young-Ki; Friedrich, Craig; Choi, Chang Kyoung

2014-01-01

An electro-osmosis (EOS) diode pumping platform capable of culturing cells in fluidic cellular micro-environments particularly at low volume flow rates has been developed. Diode pumps have been shown to be a viable alternative to mechanically driven pumps. Typically electrokinetic micro-pumps were limited to low-concentration solutions (≤10 mM). In our approach, surface mount diodes were embedded along the sidewalls of a microchannel to rectify externally applied alternating current into pulsed direct current power across the diodes in order to generate EOS flows. This approach has for the first time generated flows at ultra-low flow rates (from 2.0 nl/s to 12.3 nl/s) in aqueous solutions with concentrations greater than 100 mM. The range of flow was generated by changing the electric field strength applied to the diodes from 0.5 Vpp/cm to 10 Vpp/cm. Embedding an additional diode on the upper surface of the enclosed microchannel increased flow rates further. We characterized the diode pump-driven fluidics in terms of intensities and frequencies of electric inputs, pH values of solutions, and solution types. As part of this study, we found that the growth of A549 human lung cancer cells was positively affected in the microfluidic diode pumping system. Though the chemical reaction compromised the fluidic control overtime, the system could be maintained fully functional over a long time if the solution was changed every hour. In conclusion, the advantage of miniature size and ability to accurately control fluids at ultra-low volume flow rates can make this diode pumping system attractive to lab-on-a-chip applications and biomedical engineering in vitro studies. PMID:25379101

Temporary persistence of conduction block after prolonged kilohertz frequency alternating current on rat sciatic nerve

NASA Astrophysics Data System (ADS)

Bhadra, Narendra; Foldes, Emily; Vrabec, Tina; Kilgore, Kevin; Bhadra, Niloy

2018-02-01

Objective. Application of kilohertz frequency alternating current (KHFAC) waveforms can result in nerve conduction block that is induced in less than a second. Conduction recovers within seconds when KHFAC is applied for about 5-10 min. This study investigated the effect of repeated and prolonged application of KHFAC on rat sciatic nerve with bipolar platinum electrodes. Approach. Varying durations of KHFAC at signal amplitudes for conduction block with intervals of no stimulus were studied. Nerve conduction was monitored by recording peak Gastrocnemius muscle force utilizing stimulation electrodes proximal (PS) and distal (DS) to a blocking electrode. The PS signal traveled through the block zone on the nerve, while the DS went directly to the motor end-plate junction. The PS/DS force ratio provided a measure of conduction patency of the nerve in the block zone. Main results. Conduction recovery times were found to be significantly affected by the cumulative duration of KHFAC application. Peak stimulated muscle force returned to pre-block levels immediately after cessation of KHFAC delivery when it was applied for less than about 15 min. They fell significantly but recovered to near pre-block levels for cumulative stimulus of 50  ±  20 min, for the tested On/Off times and frequencies. Conduction recovered in two phases, an initial fast one (60-80% recovery), followed by a slower phase. No permanent conduction block was seen at the end of the observation period during any experiment. Significance. This carry-over block effect may be exploited to provide continuous conduction block in peripheral nerves without continuous application of KHFAC.

Oscillatory Reinstatement Enhances Declarative Memory.

PubMed

Javadi, Amir-Homayoun; Glen, James C; Halkiopoulos, Sara; Schulz, Mei; Spiers, Hugo J

2017-10-11

Declarative memory recall is thought to involve the reinstatement of neural activity patterns that occurred previously during encoding. Consistent with this view, greater similarity between patterns of activity recorded during encoding and retrieval has been found to predict better memory performance in a number of studies. Recent models have argued that neural oscillations may be crucial to reinstatement for successful memory retrieval. However, to date, no causal evidence has been provided to support this theory, nor has the impact of oscillatory electrical brain stimulation during encoding and retrieval been assessed. To explore this we used transcranial alternating current stimulation over the left dorsolateral prefrontal cortex of human participants [ n = 70, 45 females; age mean (SD) = 22.12 (2.16)] during a declarative memory task. Participants received either the same frequency during encoding and retrieval (60-60 or 90-90 Hz) or different frequencies (60-90 or 90-60 Hz). When frequencies matched there was a significant memory improvement (at both 60 and 90 Hz) relative to sham stimulation. No improvement occurred when frequencies mismatched. Our results provide support for the role of oscillatory reinstatement in memory retrieval. SIGNIFICANCE STATEMENT Recent neurobiological models of memory have argued that large-scale neural oscillations are reinstated to support successful memory retrieval. Here we used transcranial alternating current stimulation (tACS) to test these models. tACS has recently been shown to induce neural oscillations at the frequency stimulated. We stimulated over the left dorsolateral prefrontal cortex during a declarative memory task involving learning a set of words. We found that tACS applied at the same frequency during encoding and retrieval enhances memory. We also find no difference between the two applied frequencies. Thus our results are consistent with the proposal that reinstatement of neural oscillations during retrieval supports successful memory retrieval. Copyright © 2017 Javadi et al.

Alternative Fuels Data Center

Science.gov Websites

Alternative Fuel Vehicle (AFV) Tax Exemption New passenger cars, light-duty trucks, and medium-duty base model price of $42,500 or less. The sales tax exemption applies to up to $32,000 of a vehicle's sold after June 15, 2015, 7,500, has been reached, and the sales tax exemption applies to vehicles

Volatility Measurements Applied to Information Systems

DTIC Science & Technology

2013-09-01

Measuring and forecasting volatility through historical volatility and a normal distribution provides a volatility expectation from which managers can...been argued as more accurate alternative to historical volatility (Ederington & Guan, 2006). Other alternatives include the daily squared returns...Ederington, L. H., & Guan, W. (2006). Measuring historical volatility . Journal of Applied Finance, 16(1), 5–14. Retrieved from http

Performance characterization of a solenoid-type gas valve for the H- magnetron source at FNAL

NASA Astrophysics Data System (ADS)

Sosa, A.; Bollinger, D. S.; Karns, P. R.

2017-08-01

The magnetron-style H- ion sources currently in operation at Fermilab use piezoelectric gas valves to function. This kind of gas valve is sensitive to small changes in ambient temperature, which affect the stability and performance of the ion source. This motivates the need to find an alternative way of feeding H2 gas into the source. A solenoid-type gas valve has been characterized in a dedicated off-line test stand to assess the feasibility of its use in the operational ion sources. H- ion beams have been extracted at 35 keV using this valve. In this study, the performance of the solenoid gas valve has been characterized measuring the beam current output of the magnetron source with respect to the voltage and pulse width of the signal applied to the gas valve.

Cascaded resonant bridge converters

NASA Technical Reports Server (NTRS)

Stuart, Thomas A. (Inventor)

1989-01-01

A converter for converting a low voltage direct current power source to a higher voltage, high frequency alternating current output for use in an electrical system where it is desired to use low weight cables and other circuit elements. The converter has a first stage series resonant (Schwarz) converter which converts the direct current power source to an alternating current by means of switching elements that are operated by a variable frequency voltage regulator, a transformer to step up the voltage of the alternating current, and a rectifier bridge to convert the alternating current to a direct current first stage output. The converter further has a second stage series resonant (Schwarz) converter which is connected in series to the first stage converter to receive its direct current output and convert it to a second stage high frequency alternating current output by means of switching elements that are operated by a fixed frequency oscillator. The voltage of the second stage output is controlled at a relatively constant value by controlling the first stage output voltage, which is accomplished by controlling the frequency of the first stage variable frequency voltage controller in response to second stage voltage. Fault tolerance in the event of a load short circuit is provided by making the operation of the first stage variable frequency voltage controller responsive to first and second stage current limiting devices. The second stage output is connected to a rectifier bridge whose output is connected to the input of the second stage to provide good regulation of output voltage wave form at low system loads.

Transcranial electric stimulation for the investigation of speech perception and comprehension

PubMed Central

Zoefel, Benedikt; Davis, Matthew H.

2017-01-01

ABSTRACT Transcranial electric stimulation (tES), comprising transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), involves applying weak electrical current to the scalp, which can be used to modulate membrane potentials and thereby modify neural activity. Critically, behavioural or perceptual consequences of this modulation provide evidence for a causal role of neural activity in the stimulated brain region for the observed outcome. We present tES as a tool for the investigation of which neural responses are necessary for successful speech perception and comprehension. We summarise existing studies, along with challenges that need to be overcome, potential solutions, and future directions. We conclude that, although standardised stimulation parameters still need to be established, tES is a promising tool for revealing the neural basis of speech processing. Future research can use this method to explore the causal role of brain regions and neural processes for the perception and comprehension of speech. PMID:28670598

Alternative laser system for cesium magneto-optical trap via optical injection locking to sideband of a 9-GHz current-modulated diode laser.

PubMed

Diao, Wenting; He, Jun; Liu, Zhi; Yang, Baodong; Wang, Junmin

2012-03-26

By optical injection of an 852-nm extended-cavity diode laser (master laser) to lock the + 1-order sideband of a ~9-GHz-current-modulated diode laser (slave laser), we generate a pair of phase-locked lasers with a frequency difference up to ~9-GHz for a cesium (Cs) magneto-optical trap (MOT) with convenient tuning capability. For a cesium MOT, the master laser acts as repumping laser, locked to the Cs 6S₁/₂ (F = 3) - 6P₃/₂ (F' = 4) transition. When the + 1-order sideband of the 8.9536-GHz-current-modulated slave laser is optically injection-locked, the carrier operates on the Cs 6S₁/₂ (F = 4) - 6P₃/₂ (F' = 5) cooling cycle transition with -12 MHz detuning and acts as cooling/trapping laser. When carrying a 9.1926-GHz modulation signal, this phase-locked laser system can be applied in the fields of coherent population trapping and coherent manipulation of Cs atomic ground states.

Conjunctive-management models for sustained yield of stream-aquifer systems

USGS Publications Warehouse

Barlow, P.M.; Ahlfeld, D.P.; Dickerman, D.C.

2003-01-01

Conjunctive-management models that couple numerical simulation with linear optimization were developed to evaluate trade-offs between groundwater withdrawals and streamflow depletions for alluvial-valley stream-aquifer systems representative of those of the northeastern United States. A conjunctive-management model developed for a hypothetical stream-aquifer system was used to assess the effect of interannual hydrologic variability on minimum monthly streamflow requirements. The conjunctive-management model was applied to the Hunt-Annaquatucket-Pettaquamscutt stream-aquifer system of central Rhode Island. Results show that it is possible to increase the amount of current withdrawal from the aquifer by as much as 50% by modifying current withdrawal schedules, modifying the number and configuration of wells in the supply-well network, or allowing increased streamflow depletion in the Annaquatucket and Pettaquamscutt rivers. Alternatively, it is possible to reduce current rates of streamflow depletion in the Hunt River by as much as 35% during the summer, but such reductions would result increases in groundwater withdrawals.

Performance analysis of a diesel engine driven brushless alternator with combined AC and thyristor fed DC loads through PSPICE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayanan, S.S.Y.; Ananthakrishnan, P.; Hangari, V.U.

1995-12-31

A brushless alternator with damper windings in the main alternator and with combined ac and thyristor fed dc loads has been handled ab initio as a total modeling and simulation problem for which a complete steady state performance prediction algorithm has been developed through proper application of Park`s equivalent circuit approach individually to the main and exciter alternator units of the brushless alternator. Details of the problems faced during implementation of this algorithm through PSPICE for the case of a specific 125 kVA brushless alternator as well as methods adopted for successfully overcoming the same have then been presented. Finallymore » a comparison of the predicted performance with those obtained experimentally for this 125 kVA unit has also been provided for the cases of both thyristor fed dc load alone as well as combined ac and thyristor fed dc loads. To enable proper calculation of derating factors to be used in the design of such brushless alternators, the simulation results then include harmonic analysis of the alternator output voltage and current waveforms at the point of common connection of the ac and thyristor fed dc load, damper winding currents, main alternator field winding current, exciter alternator armature voltage and the alternator developed torque and torque angle pulsations.« less

Cognitive Activation by Central Thalamic Stimulation: The Yerkes-Dodson Law Revisited.

PubMed Central

Mair, Robert G.; Onos, Kristen D.; Hembrook, Jacqueline R.

2011-01-01

Central thalamus regulates forebrain arousal, influencing activity in distributed neural networks that give rise to organized actions during alert, wakeful states. Central thalamus has been implicated in working memory by the effects of lesions and microinjected drugs in this part of the brain. Lesions and drugs that inhibit neural activity have been found to impair working memory. Drugs that increase activity have been found to enhance and impair memory depending on the dose tested. Electrical deep brain stimulation (DBS) similarly enhances working memory at low stimulating currents and impairs it at higher currents. These effects are time dependent. They were observed when DBS was applied during the memory delay (retention) or choice response (retrieval) but not earlier in trials during the sample (acquisition) phase. The effects of microinjected drugs and DBS are consistent with the Yerkes-Dodson law, which describes an inverted-U relationship between arousal and behavioral performance. Alternatively these results may reflect desensitization associated with higher levels of stimulation, spread of drugs or current to adjacent structures, or activation of less sensitive neurons or receptors at higher DBS currents or drug doses. PMID:22013395

Current reversals and metastable states in the infinite Bose-Hubbard chain with local particle loss

NASA Astrophysics Data System (ADS)

Kiefer-Emmanouilidis, M.; Sirker, J.

2017-12-01

We present an algorithm which combines the quantum trajectory approach to open quantum systems with a density-matrix renormalization-group scheme for infinite one-dimensional lattice systems. We apply this method to investigate the long-time dynamics in the Bose-Hubbard model with local particle loss starting from a Mott-insulating initial state with one boson per site. While the short-time dynamics can be described even quantitatively by an equation of motion (EOM) approach at the mean-field level, many-body interactions lead to unexpected effects at intermediate and long times: local particle currents far away from the dissipative site start to reverse direction ultimately leading to a metastable state with a total particle current pointing away from the lossy site. An alternative EOM approach based on an effective fermion model shows that the reversal of currents can be understood qualitatively by the creation of holon-doublon pairs at the edge of the region of reduced particle density. The doublons are then able to escape while the holes move towards the dissipative site, a process reminiscent—in a loose sense—of Hawking radiation.

Microfabricated teeter-totter resonator

DOEpatents

Adkins, Douglas Ray; Heller, Edwin J.; Shul, Randy J.

2004-11-23

A microfabricated teeter-totter resonator comprises a frame, a paddle pivotably anchored to the frame by pivot arms that define an axis of rotation, a current conductor line on a surface of the paddle, means for applying a static magnetic field substantially perpendicular to the rotational axis and in the plane of the paddle, and means for energizing the current conductor line with an alternating current. A Lorentz force is generated by the interaction of the magnetic field with the current flowing in the conductor line, causing the paddle to oscillate about the axis of rotation. The teeter-totter resonator can be fabricated with micromachining techniques with materials used in the integrated circuits manufacturing industry. The microfabricated teeter-totter resonator has many varied applications, both as an actuation device and as a sensor. When used as a chemical sensor, a chemically sensitive coating can be disposed on one or both surfaces of the paddle to enhance the absorption of chemical analytes from a fluid stream. The resulting mass change can be detected as a change in the resonant frequency or phase of the oscillatory motion of the paddle.

Influence of Concurrent Finger Movements on Transcranial Direct Current Stimulation (tDCS)-Induced Aftereffects.

PubMed

Shirota, Yuichiro; Terney, Daniella; Antal, Andrea; Paulus, Walter

2017-01-01

Transcranial direct current stimulation (tDCS) has been reported to have bidirectional influence on the amplitude of motor-evoked potentials (MEPs) in resting participants in a polarity-specific manner: anodal tDCS increased and cathodal tDCS decreased them. More recently, the effects of tDCS have been shown to depend on a number of additional factors. We investigated whether a small variety of movements involving target and non-target muscles could differentially modify the efficacy of tDCS. MEPs were elicited from the right first dorsal interosseous muscle, defined as the target muscle, by single pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1). During M1 tDCS, which lasted for 10 min applying anodal, cathodal, or sham condition, the participants were instructed to squeeze a ball with their right hand (Task 1), to move their right index finger only in the medial (Task 2), in the lateral direction (Task 3), or in medial and lateral direction alternatively (Task 4). Anodal tDCS reduced MEP amplitudes measured in Task 1 and Task 2, but to a lesser extent in the latter. In Task 3, anodal tDCS led to greater MEP amplitudes than cathodal stimulation. Alternating movements resulted in no effect of tDCS on MEP amplitude (Task 4). The results are congruent with the current notion that the aftereffects of tDCS are highly variable relying on a number of factors including the type of movements executed during stimulation.

A quantitative risk assessment model to evaluate effective border control measures for rabies prevention.

PubMed

Weng, Hsin-Yi; Wu, Pei-I; Yang, Ping-Cheng; Tsai, Yi-Lun; Chang, Chao-Chin

2010-01-01

Border control is the primary method to prevent rabies emergence. This study developed a quantitative risk model incorporating stochastic processes to evaluate whether border control measures could efficiently prevent rabies introduction through importation of cats and dogs using Taiwan as an example. Both legal importation and illegal smuggling were investigated. The impacts of reduced quarantine and/or waiting period on the risk of rabies introduction were also evaluated. The results showed that Taiwan's current animal importation policy could effectively prevent rabies introduction through legal importation of cats and dogs. The median risk of a rabid animal to penetrate current border control measures and enter Taiwan was 5.33 x 10(-8) (95th percentile: 3.20 x 10(-7)). However, illegal smuggling may pose Taiwan to the great risk of rabies emergence. Reduction of quarantine and/or waiting period would affect the risk differently, depending on the applied assumptions, such as increased vaccination coverage, enforced custom checking, and/or change in number of legal importations. Although the changes in the estimated risk under the assumed alternatives were not substantial except for completely abolishing quarantine, the consequences of rabies introduction may yet be considered to be significant in a rabies-free area. Therefore, a comprehensive benefit-cost analysis needs to be conducted before recommending these alternative measures.

Novel design of high voltage pulse source for efficient dielectric barrier discharge generation by using silicon diodes for alternating current.

PubMed

Truong, Hoa Thi; Hayashi, Misaki; Uesugi, Yoshihiko; Tanaka, Yasunori; Ishijima, Tatsuo

2017-06-01

This work focuses on design, construction, and optimization of configuration of a novel high voltage pulse power source for large-scale dielectric barrier discharge (DBD) generation. The pulses were generated by using the high-speed switching characteristic of an inexpensive device called silicon diodes for alternating current and the self-terminated characteristic of DBD. The operation started to be powered by a primary DC low voltage power supply flexibly equipped with a commercial DC power supply, or a battery, or DC output of an independent photovoltaic system without transformer employment. This flexible connection to different types of primary power supply could provide a promising solution for the application of DBD, especially in the area without power grid connection. The simple modular structure, non-control requirement, transformer elimination, and a minimum number of levels in voltage conversion could lead to a reduction in size, weight, simple maintenance, low cost of installation, and high scalability of a DBD generator. The performance of this pulse source has been validated by a load of resistor. A good agreement between theoretically estimated and experimentally measured responses has been achieved. The pulse source has also been successfully applied for an efficient DBD plasma generation.

Novel design of high voltage pulse source for efficient dielectric barrier discharge generation by using silicon diodes for alternating current

NASA Astrophysics Data System (ADS)

Truong, Hoa Thi; Hayashi, Misaki; Uesugi, Yoshihiko; Tanaka, Yasunori; Ishijima, Tatsuo

2017-06-01

This work focuses on design, construction, and optimization of configuration of a novel high voltage pulse power source for large-scale dielectric barrier discharge (DBD) generation. The pulses were generated by using the high-speed switching characteristic of an inexpensive device called silicon diodes for alternating current and the self-terminated characteristic of DBD. The operation started to be powered by a primary DC low voltage power supply flexibly equipped with a commercial DC power supply, or a battery, or DC output of an independent photovoltaic system without transformer employment. This flexible connection to different types of primary power supply could provide a promising solution for the application of DBD, especially in the area without power grid connection. The simple modular structure, non-control requirement, transformer elimination, and a minimum number of levels in voltage conversion could lead to a reduction in size, weight, simple maintenance, low cost of installation, and high scalability of a DBD generator. The performance of this pulse source has been validated by a load of resistor. A good agreement between theoretically estimated and experimentally measured responses has been achieved. The pulse source has also been successfully applied for an efficient DBD plasma generation.

From amusic to musical?--Improving pitch memory in congenital amusia with transcranial alternating current stimulation.

PubMed

Schaal, Nora K; Pfeifer, Jasmin; Krause, Vanessa; Pollok, Bettina

2015-11-01

Brain imaging studies highlighted structural differences in congenital amusia, a life-long perceptual disorder that is associated with pitch perception and pitch memory deficits. A functional anomaly characterized by decreased low gamma oscillations (30-40 Hz range) in the right dorsolateral prefrontal cortex (DLPFC) during pitch memory has been revealed recently. Thus, the present study investigates whether applying transcranial alternating current stimulation (tACS) at 35 Hz to the right DLPFC would improve pitch memory. Nine amusics took part in two tACS sessions (either 35 Hz or 90 Hz) and completed a pitch and visual memory task before and during stimulation. 35 Hz stimulation facilitated pitch memory significantly. No modulation effects were found with 90 Hz stimulation or on the visual task. While amusics showed a selective impairment of pitch memory before stimulation, the performance during 35 Hz stimulation was not significantly different to healthy controls anymore. Taken together, the study shows that modulating the right DLPFC with 35 Hz tACS in congenital amusia selectively improves pitch memory performance supporting the hypothesis that decreased gamma oscillations within the DLPFC are causally involved in disturbed pitch memory and highlight the potential use of tACS to interact with cognitive processes. Copyright © 2015 Elsevier B.V. All rights reserved.

Alternating current electric fields of varying frequencies: effects on proliferation and differentiation of porcine neural progenitor cells.

PubMed

Lim, Ji-Hey; McCullen, Seth D; Piedrahita, Jorge A; Loboa, Elizabeth G; Olby, Natasha J

2013-10-01

Application of sinusoidal electric fields (EFs) has been observed to affect cellular processes, including alignment, proliferation, and differentiation. In the present study, we applied low-frequency alternating current (AC) EFs to porcine neural progenitor cells (pNPCs) and investigated the effects on cell patterning, proliferation, and differentiation. pNPCs were grown directly on interdigitated electrodes (IDEs) localizing the EFs to a region accessible visually for fluorescence-based assays. Cultures of pNPCs were exposed to EFs (1 V/cm) of 1 Hz, 10 Hz, and 50 Hz for 3, 7, and 14 days and compared to control cultures. Immunocytochemistry was performed to evaluate the expression of neural markers. pNPCs grew uniformly with no evidence of alignment to the EFs and no change in cell numbers when compared with controls. Nestin expression was shown in all groups at 3 and 7 days, but not at 14 days. NG2 expression was low in all groups. Co-expression of glial fibrillary acidic protein (GFAP) and TUJ1 was significantly higher in the cultures exposed to 10- and 50-Hz EFs than the controls. In summary, sinusoidal AC EFs via IDEs did not alter the alignment and proliferation of pNPCs, but higher frequency stimulation appeared to delay differentiation into mature astrocytes.

Rapid immunocytochemistry based on alternating current electric field using squash smear preparation of central nervous system tumors.

PubMed

Moriya, Jun; Tanino, Mishie Ann; Takenami, Tomoko; Endoh, Tomoko; Urushido, Masana; Kato, Yasutaka; Wang, Lei; Kimura, Taichi; Tsuda, Masumi; Nishihara, Hiroshi; Tanaka, Shinya

2016-01-01

The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine (BCNU) wafers requires a conclusive diagnosis of high-grade glioma proven by intraoperative diagnosis. Recently, we demonstrated the usefulness of rapid immunohistochemistry (R-IHC) that facilitates antigen-antibody reaction under alternative current (AC) electric field in the intraoperative diagnosis of CNS tumors; however, a higher proportion of water and lipid in the brain parenchyma sometimes leads to freezing artifacts, resulting in poor quality of frozen sections. On the other hand, squash smear preparation of CNS tumors for cytology does not affect the frozen artifacts, and the importance of smear preparation is now being re-recognized as being better than that of the tissue sections. In this study, we established the rapid immunocytochemistry (R-ICC) protocol for squash smears of CNS tumors using AC electric field that takes only 22 min, and demonstrated its usefulness for semi-quantitative Ki-67/MIB-1 labeling index and CD 20 by R-ICC for intraoperative diagnosis. R-ICC by AC electric field may become a substantial tool for compensating R-IHC and will be applied for broad antibodies in the future.

Mass spectrometry in plant metabolomics strategies: from analytical platforms to data acquisition and processing.

PubMed

Ernst, Madeleine; Silva, Denise Brentan; Silva, Ricardo Roberto; Vêncio, Ricardo Z N; Lopes, Norberto Peporine

2014-06-01

Covering: up to 2013. Plant metabolomics is a relatively recent research field that has gained increasing interest in the past few years. Up to the present day numerous review articles and guide books on the subject have been published. This review article focuses on the current applications and limitations of the modern mass spectrometry techniques, especially in combination with electrospray ionisation (ESI), an ionisation method which is most commonly applied in metabolomics studies. As a possible alternative to ESI, perspectives on matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) in metabolomics studies are introduced, a method which still is not widespread in the field. In metabolomics studies the results must always be interpreted in the context of the applied sampling procedures as well as data analysis. Different sampling strategies are introduced and the importance of data analysis is illustrated in the example of metabolic network modelling.

Measuring the lateral charge-carrier mobility in metal-insulator-semiconductor capacitors via Kelvin-probe.

PubMed

Milotti, Valeria; Pietsch, Manuel; Strunk, Karl-Philipp; Melzer, Christian

2018-01-01

We report a Kelvin-probe method to investigate the lateral charge-transport properties of semiconductors, most notably the charge-carrier mobility. The method is based on successive charging and discharging of a pre-biased metal-insulator-semiconductor stack by an alternating voltage applied to one edge of a laterally confined semiconductor layer. The charge carriers spreading along the insulator-semiconductor interface are directly measured by a Kelvin-probe, following the time evolution of the surface potential. A model is presented, describing the device response for arbitrary applied biases allowing the extraction of the lateral charge-carrier mobility from experimentally measured surface potentials. The method is tested using the organic semiconductor poly(3-hexylthiophene), and the extracted mobilities are validated through current voltage measurements on respective field-effect transistors. Our widely applicable approach enables robust measurements of the lateral charge-carrier mobility in semiconductors with weak impact from the utilized contact materials.

Measuring the lateral charge-carrier mobility in metal-insulator-semiconductor capacitors via Kelvin-probe

NASA Astrophysics Data System (ADS)

Milotti, Valeria; Pietsch, Manuel; Strunk, Karl-Philipp; Melzer, Christian

2018-01-01

We report a Kelvin-probe method to investigate the lateral charge-transport properties of semiconductors, most notably the charge-carrier mobility. The method is based on successive charging and discharging of a pre-biased metal-insulator-semiconductor stack by an alternating voltage applied to one edge of a laterally confined semiconductor layer. The charge carriers spreading along the insulator-semiconductor interface are directly measured by a Kelvin-probe, following the time evolution of the surface potential. A model is presented, describing the device response for arbitrary applied biases allowing the extraction of the lateral charge-carrier mobility from experimentally measured surface potentials. The method is tested using the organic semiconductor poly(3-hexylthiophene), and the extracted mobilities are validated through current voltage measurements on respective field-effect transistors. Our widely applicable approach enables robust measurements of the lateral charge-carrier mobility in semiconductors with weak impact from the utilized contact materials.

Advances in Molecular Rotational Spectroscopy for Applied Science

NASA Astrophysics Data System (ADS)

Harris, Brent; Fields, Shelby S.; Pulliam, Robin; Muckle, Matt; Neill, Justin L.

2017-06-01

Advances in chemical sensitivity and robust, solid-state designs for microwave/millimeter-wave instrumentation compel the expansion of molecular rotational spectroscopy as research tool into applied science. It is familiar to consider molecular rotational spectroscopy for air analysis. Those techniques for molecular rotational spectroscopy are included in our presentation of a more broad application space for materials analysis using Fourier Transform Molecular Rotational Resonance (FT-MRR) spectrometers. There are potentially transformative advantages for direct gas analysis of complex mixtures, determination of unknown evolved gases with parts per trillion detection limits in solid materials, and unambiguous chiral determination. The introduction of FT-MRR as an alternative detection principle for analytical chemistry has created a ripe research space for the development of new analytical methods and sampling equipment to fully enable FT-MRR. We present the current state of purpose-built FT-MRR instrumentation and the latest application measurements that make use of new sampling methods.

Triazole-based Zn²⁺-specific molecular marker for fluorescence bioimaging.

PubMed

Sinha, Sougata; Mukherjee, Trinetra; Mathew, Jomon; Mukhopadhyay, Subhra K; Ghosh, Subrata

2014-04-25

Fluorescence bioimaging potential, both in vitro and in vivo, of a yellow emissive triazole-based molecular marker has been investigated and demonstrated. Three different kinds of cells, viz Bacillus thuringiensis, Candida albicans, and Techoma stans pollen grains were used to investigate the intracellular zinc imaging potential of 1 (in vitro studies). Fluorescence imaging of translocation of zinc through the stem of small herb, Peperomia pellucida, having transparent stem proved in vivo bioimaging capability of 1. This approach will enable in screening cell permeability and biostability of a newly developed probe. Similarly, the current method for detection and localization of zinc in Gram seed sprouts could be an easy and potential alternative of the existing analytical methods to investigate the efficiency of various strategies applied for increasing zinc-content in cereal crops. The probe-zinc ensemble has efficiently been applied for detecting phosphate-based biomolecules. Copyright © 2014 Elsevier B.V. All rights reserved.

46 CFR 199.630 - Alternatives for passenger vessels in a specified service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... applies if the vessel operates in shallow water not more than 3 miles from shore where the vessel cannot sink deep enough to submerge the topmost deck. 5 Alternative applies if the vessel operates on... requirements for survival craft in § 199.201(b) if the vessel operates— (1) On a route that is in shallow water...

Portable power supply options for positive airway pressure devices.

PubMed

Riaz, Muhammad; Certal, Victor; Camacho, Macario

2015-01-01

Patients with obstructive sleep apnea (OSA) often face the challenge of how to power their positive airway pressure (PAP) devices when alternating current power supplies are not available in remote areas with lack of electricity or frequent power outages. This article elucidates portable power supply options for PAP devices with the aim to increase alternative power source awareness among medical providers. A search of scientific databases (Medline, Scopus, Web of Science, Google Scholar, and the Cochrane Library) was carried out on the topic of alternative portable power supply options for treatment of OSA. Scientific databases listed above yielded only limited results. Most articles were found via Google search. These articles were reviewed for alternative power supply options for OSA patients when alternating current is not available. The power supply options in this article include lead-acid batteries (starter, marine and deep-cycle batteries), lithium ion batteries, solar kits, battery packs, backup power systems, portable generators, and travel-size PAP devices. There are several options to power PAP devices with direct current when alternating current is not available. Knowledgeable primary care physicians especially in rural and remote areas can help OSA patients improve PAP compliance in order to mitigate morbidity and long-term complications of OSA.

30 CFR 77.900-2 - Testing, examination, and maintenance of circuit breakers; record.

Code of Federal Regulations, 2011 CFR

2011-07-01

... protecting low- and medium-voltage circuits serving three-phase alternating current equipment and such record... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Low- and Medium-Voltage Alternating Current Circuits...

30 CFR 77.900-1 - Testing, examination, and maintenance of circuit breakers; procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... protecting low- and medium-voltage circuits serving portable or mobile three-phase alternating current... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Low- and Medium-Voltage Alternating Current Circuits...

30 CFR 77.900-2 - Testing, examination, and maintenance of circuit breakers; record.

Code of Federal Regulations, 2010 CFR

2010-07-01

... protecting low- and medium-voltage circuits serving three-phase alternating current equipment and such record... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Low- and Medium-Voltage Alternating Current Circuits...

30 CFR 77.900-1 - Testing, examination, and maintenance of circuit breakers; procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... protecting low- and medium-voltage circuits serving portable or mobile three-phase alternating current... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Low- and Medium-Voltage Alternating Current Circuits...

76 FR 6496 - Special Flight Rules Area in the Vicinity of Grand Canyon National Park, Draft Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... being considered include: Alternative A Current Condition: Key elements are corridors open year round, annual allocation cap of 93,971, and no quiet technology incentive. Current tours for helicopters and... to quiet technology aircraft. Alternative F Modified Current Condition: Key elements are similar to...

A Project-Based, STEM-Integrated Alternative Energy Team Challenge for Teachers

ERIC Educational Resources Information Center

Felix, Allison; Harris, John

2010-01-01

The topic of alternative energy is not only relevant to a multitude of issues today, it is also an effective vehicle for developing instruction that applies across a variety of content disciplines and academic standards. Since many of the issues associated with alternative energy are open-ended, alternative energy also lends itself to…

System architectures for telerobotic research

NASA Technical Reports Server (NTRS)

Harrison, F. Wallace

1989-01-01

Several activities are performed related to the definition and creation of telerobotic systems. The effort and investment required to create architectures for these complex systems can be enormous; however, the magnitude of process can be reduced if structured design techniques are applied. A number of informal methodologies supporting certain aspects of the design process are available. More recently, prototypes of integrated tools supporting all phases of system design from requirements analysis to code generation and hardware layout have begun to appear. Activities related to system architecture of telerobots are described, including current activities which are designed to provide a methodology for the comparison and quantitative analysis of alternative system architectures.

Segmenting and targeting American university students to promote responsible alcohol use: a case for applying social marketing principles.

PubMed

Deshpande, Sameer; Rundle-Thiele, Sharyn

2011-10-01

The current study contributes to the social marketing literature in the American university binge-drinking context in three innovative ways. First, it profiles drinking segments by "values" and "expectancies" sought from behaviors. Second, the study compares segment values and expectancies of two competing behaviors, that is, binge drinking and participation in alternative activities. Third, the study compares the influence of a variety of factors on both behaviors in each segment. Finally, based on these findings and feedback from eight university alcohol prevention experts, appropriate strategies to promote responsible alcohol use for each segment are proposed.

The metallofullerene field-induced single-ion magnet HoSc2 N@C80.

PubMed

Dreiser, Jan; Westerström, Rasmus; Zhang, Yang; Popov, Alexey A; Dunsch, Lothar; Krämer, Karl; Liu, Shi-Xia; Decurtins, Silvio; Greber, Thomas

2014-10-13

The low-temperature magnetic properties of the endohedral metallofullerene HoSc2 N@C80 have been studied by superconducting quantum interference device (SQUID) magnetometry. Alternating current (ac) susceptibility measurements reveal that this molecule exhibits slow relaxation of magnetization in a small applied field with timescales in the order of milliseconds. The equilibrium magnetic properties of HoSc2 N@C80 indicate strong magnetic anisotropy. The large differences in magnetization relaxation times between the present compound and the previously investigated DySc2 N@C80 are discussed. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

High-throughput formation and control of monodisperse liquid crystals droplets driven by an alternating current electric field in a microfluidic device

NASA Astrophysics Data System (ADS)

Belloul, M.; Bartolo, J.-F.; Ziraoui, B.; Coldren, F.; Taly, V.; El Abed, A. I.

2013-07-01

We investigate the effect of an applied ac high voltage on a confined stable nematic liquid crystal (LC) in a microfluidic device and show that this actuation leads to the formation of highly monodisperse microdroplets with an unexpected constant mean size over a large interval of the forcing frequency F and with a droplets production frequency f ≃2F. We show also that despite the nonlinear feature of the droplets formation mechanism, droplets size, and size distribution are governed simply by the LC flow rate Qd and the forcing frequency F.

Digital electronic bone growth stimulator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kronberg, J.W.

1995-05-09

A device is described for stimulating bone tissue by applying a low level alternating current signal directly to the patient`s skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated tomore » the underlying bone structures. 5 figs.« less

Functional Analyses and Treatment of Precursor Behavior

PubMed Central

Najdowski, Adel C; Wallace, Michele D; Ellsworth, Carrie L; MacAleese, Alicia N; Cleveland, Jackie M

2008-01-01

Functional analysis has been demonstrated to be an effective method to identify environmental variables that maintain problem behavior. However, there are cases when conducting functional analyses of severe problem behavior may be contraindicated. The current study applied functional analysis procedures to a class of behavior that preceded severe problem behavior (precursor behavior) and evaluated treatments based on the outcomes of the functional analyses of precursor behavior. Responding for all participants was differentiated during the functional analyses, and individualized treatments eliminated precursor behavior. These results suggest that functional analysis of precursor behavior may offer an alternative, indirect method to assess the operant function of severe problem behavior. PMID:18468282

Digital electronic bone growth stimulator

DOEpatents

Kronberg, J.W.

1995-05-09

A device is described for stimulating bone tissue by applying a low level alternating current signal directly to the patient`s skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated to the underlying bone structures. 5 figs.

Evaluation of small area crop estimation techniques using LANDSAT- and ground-derived data. [South Dakota

NASA Technical Reports Server (NTRS)

Amis, M. L.; Martin, M. V.; Mcguire, W. G.; Shen, S. S. (Principal Investigator)

1982-01-01

Studies completed in fiscal year 1981 in support of the clustering/classification and preprocessing activities of the Domestic Crops and Land Cover project. The theme throughout the study was the improvement of subanalysis district (usually county level) crop hectarage estimates, as reflected in the following three objectives: (1) to evaluate the current U.S. Department of Agriculture Statistical Reporting Service regression approach to crop area estimation as applied to the problem of obtaining subanalysis district estimates; (2) to develop and test alternative approaches to subanalysis district estimation; and (3) to develop and test preprocessing techniques for use in improving subanalysis district estimates.

Preparation and Characterization of Soybean Oil-Based Polyurethanes for Digital Doming Applications

PubMed Central

Pantone, Vincenzo; Laurenza, Amelita Grazia; Annese, Cosimo; Fracassi, Francesco; Fini, Paola; Nacci, Angelo; Russo, Antonella; Fusco, Caterina

2017-01-01

Polyurethane-resin doming is currently one of the fastest growing markets in the field of industrial graphics and product identification. Semi-rigid bio-based polyurethanes were prepared deriving from soybean oil as a valuable alternative to fossil materials for digital doming and applied to digital mosaic technology. Bio-resins produced can favorably compete with the analogous fossil polymers, giving high-quality surface coatings (ascertained by SEM analyses). In addition, polyurethane synthesis was accomplished by using a mercury- and tin-free catalyst (the commercially available zinc derivative K22) bringing significant benefits in terms of cost efficiency and eco-sustainability. PMID:28773208

An efficient calibration method for SQUID measurement system using three orthogonal Helmholtz coils

NASA Astrophysics Data System (ADS)

Hua, Li; Shu-Lin, Zhang; Chao-Xiang, Zhang; Xiang-Yan, Kong; Xiao-Ming, Xie

2016-06-01

For a practical superconducting quantum interference device (SQUID) based measurement system, the Tesla/volt coefficient must be accurately calibrated. In this paper, we propose a highly efficient method of calibrating a SQUID magnetometer system using three orthogonal Helmholtz coils. The Tesla/volt coefficient is regarded as the magnitude of a vector pointing to the normal direction of the pickup coil. By applying magnetic fields through a three-dimensional Helmholtz coil, the Tesla/volt coefficient can be directly calculated from magnetometer responses to the three orthogonally applied magnetic fields. Calibration with alternating current (AC) field is normally used for better signal-to-noise ratio in noisy urban environments and the results are compared with the direct current (DC) calibration to avoid possible effects due to eddy current. In our experiment, a calibration relative error of about 6.89 × 10-4 is obtained, and the error is mainly caused by the non-orthogonality of three axes of the Helmholtz coils. The method does not need precise alignment of the magnetometer inside the Helmholtz coil. It can be used for the multichannel magnetometer system calibration effectively and accurately. Project supported by the “Strategic Priority Research Program (B)” of the Chinese Academy of Sciences (Grant No. XDB04020200) and the Shanghai Municipal Science and Technology Commission Project, China (Grant No. 15DZ1940902).

Proximity and touch sensing using deformable ionic conductors (Conference Presentation)

NASA Astrophysics Data System (ADS)

Madden, John D. W.; Dobashi, Yuta; Sarwar, Mirza S.; Preston, Eden C.; Wyss, Justin K. M.; Woehling, Vincent; Nguyen, Tran-Minh-Giao; Plesse, Cedric; Vidal, Frédéric; Naficy, Sina; Spinks, Geoffrey M.

2017-04-01

There is increasing interest in creating bendable and stretchable electronic interfaces that can be worn or applied to virtually any surface. The electroactive polymer community is well placed to add value by incorporating sensors and actuators. Recent work has demonstrated transparent dielectric elastomer actuation as well as pressure, stretch or touch sensing. Here we present two alternative forms of sensing. The first uses ionically conductive and stretchable gels as electrodes in capacitive sensors that detect finger proximity. In this case the finger acts as a third electrode, reducing capacitance between the two gel electrodes as it approaches, which can be detected even during bending and stretching. Very light finger touch is readily detected even during deformation of the substrate. Lateral resolution is achieved by creating a sensor array. In the second approach, electrodes placed beneath a salt containing gel are able to detect ion currents generated by the deformation of the gel. In this approach, applied pressure results in ion currents that create a potential difference around the point of contact, leading to a voltage and current in the electrodes without any need for input electrical energy. The mechanism may be related to effects seen in ionomeric polymer metal composites (IPMCs), but with the response in plane rather than through the thickness of the film. Ultimately, these ionically conductive materials that can also be transparent and actuate, have the potential to be used in wearable devices.

Production of silver ions from colloidal silver by nanoparticle iontophoresis system.

PubMed

Tseng, Kuo-Hsiung; Liao, Chih-Yu

2011-03-01

Metal ions, especially the silver ion, were used to treat infection before the initiation of antibiotic therapy. Unfortunately, there is a lack of research on the metallic nanoparticle suspension as a reservoir for metal ion release application. For medical purposes, conversion of colloidal silver into an ionic form is necessary, but not using silver salts (e.g., AgNO3, Ag2SO4), due to the fact that the counter-ion of silver salts may cause problems to the body as the silver ion (Ag+) is consumed. The goal of this research is to develop a silver nanoparticle iontophoresis system (NIS) which can provide a relatively safe bactericidal silver ion solution with a controllable electric field. In this study, ion-selective electrodes were used to identify and observe details of the system's activity. Both qualitative and quantitative data analyses were performed. The experimental results show that the ion releasing peak time (R(PT)) has an inversely proportional relationship with the applied current and voltage. The ion releasing maximum level (R(ML)) and dosage (R(D)) are proportional to the current density and inversely proportional to the voltage, respectively. These results reveal that the nanoparticle iontophoresis system (NIS) is an alternative method for the controlled release of a metal ion and the ion's concentration profile, by controlling the magnitude of current density (1 microA/cm2 equal to 1 ppm/hour) and applied voltage.

Addressing educational challenges in veterinary medicine through the use of distance education.

PubMed

Murray, Amanda L; Sischo, William M

2007-01-01

The veterinary profession is currently facing many educational challenges, including an insufficient capacity to train and educate veterinarians for the multiple disciplines within the profession, a shortage of veterinarians in private and public practice, a shortage of faculty, a lack of human and professional diversity, and a rising cost of education resulting in extreme student debt loads. As a methodology for teaching, distance education (DE) has the potential to address many of these issues. By its very nature, DE can increase the capacity of current facilities and faculty. In addition, DE can allow students to acquire the necessary knowledge at less cost. This article describes a model for incorporating DE in the form of interactive Web-based courses, in conjunction with short, intensive residential programs, for the lecture portions of courses taught in the pre-veterinary, veterinary, and post-veterinary educational periods. In this model, the Web-based courses are used to convey the necessary core knowledge required at each step of the educational process. The residential portions are then used to apply the knowledge in such a way as to combine clinical applications with research in basic and applied sciences. Distance education can provide increased flexibility, high-quality educational experiences, and a less costly alternative for students while maximizing the reach of current faculty efforts and the capacity of existing physical structures.

Economic Implications of Potential Changes to Regulatory and Reimbursement Policies for Medical Devices

PubMed Central

Reed, Shelby D.; Shea, Alisa M.

2007-01-01

Objective To evaluate the impact of regulatory scenarios on the financial viability of medical device companies. Design We developed a model to calculate the expected net present value of a hypothetical product throughout preclinical development, clinical testing, regulatory approval, and postmarketing. We tested 3 scenarios: (1) the current regulatory environment; (2) a scenario in which medical devices are subject to the same evidence standards required for pharmaceuticals; and (3) a scenario consistent with the Coverage with Evidence Development: Coverage with Study Participation (CSP) policy proposed by the Centers for Medicare and Medicaid Services, whereby Medicare will pay for beneficiaries to receive new devices that are not currently determined to be “reasonable and necessary” if the patients participate in clinical studies or registries. Measurements and Main results When applying assumptions consistent with the implantable cardioverter-defibrillator market, the net present value at the start of development was an estimated $553 million in the current regulatory environment, $322 million in the pharmaceutical scenario, and $403 million in the CSP scenario. Sensitivity analyses showed that the device industry would likely be profitable in all 3 scenarios over a range of assumptions. Conclusions The environment in which the medical device industry operates is financially attractive. Furthermore, when compared with the alternative of applying the same evidence standards for pharmaceuticals to medical devices, the CSP policy offers improved financial incentives for medical device companies. PMID:18095045

Ion-selective detection by plasticized poly(vinyl chloride) membrane in glass nanopipette with alternating voltage modulation.

PubMed

Deng, Xiao Long; Takami, Tomohide; Son, Jong Wan; Kang, Eun Ji; Kawai, Tomoji; Park, Bae Ho

2013-08-01

An alternating current (AC) voltage modulation was applied to ion-selective observations with plasticized poly(vinyl chloride) membranes in glass nanopipettes. The liquid confronting the membranes in the nanopipettes, the conditioning process, and AC voltage modulation play important roles in the ion-selective detection. In the AC detection system developed by us, where distilled water was used as the liquid within the nanopipettes, potassium ions were selectively detected in the sample solution of sodium and potassium ions because sodium ions were captured at the membrane containing bis(12-crown-4) ionophores, before the saturation of the ionophores. The membrane lost the selectivity after the saturation. On using sodium chloride as the liquid within the nanopipette, the membrane selectively detected potassium and sodium ions before and after the saturation of ionophores, respectively. The ion-selective detection of our system can be explained by the ion extraction-diffusion-dissolution mechanism through the bis(12-crown-4) ionophores with AC voltage modulation.

Soil mechanics: breaking ground.

PubMed

Einav, Itai

2007-12-15

In soil mechanics, student's models are classified as simple models that teach us unexplained elements of behaviour; an example is the Cam clay constitutive models of critical state soil mechanics (CSSM). 'Engineer's models' are models that elaborate the theory to fit more behavioural trends; this is usually done by adding fitting parameters to the student's models. Can currently unexplained behavioural trends of soil be explained without adding fitting parameters to CSSM models, by developing alternative student's models based on modern theories?Here I apply an alternative theory to CSSM, called 'breakage mechanics', and develop a simple student's model for sand. Its unique and distinctive feature is the use of an energy balance equation that connects grain size reduction to consumption of energy, which enables us to predict how grain size distribution (gsd) evolves-an unprecedented capability in constitutive modelling. With only four parameters, the model is physically clarifying what CSSM cannot for sand: the dependency of yielding and critical state on the initial gsd and void ratio.

Electromagnetic confinement for vertical casting or containing molten metal

DOEpatents

Lari, Robert J.; Praeg, Walter F.; Turner, Larry R.

1991-01-01

An apparatus and method adapted to confine a molten metal to a region by means of an alternating electromagnetic field. As adapted for use in the present invention, the alternating electromagnetic field given by B.sub.y =(2.mu..sub.o .rho.gy).sup.1/2 (where B.sub.y is the vertical component of the magnetic field generated by the magnet at the boundary of the region; y is the distance measured downward form the top of the region, .rho. is the metal density, g is the acceleration of gravity and .mu..sub.o is the permeability of free space) induces eddy currents in the molten metal which interact with the magnetic field to retain the molten metal with a vertical boudnary. As applied to an apparatus for the continuous casting of metal sheets or rods, metal in liquid form can be continuously introduced into the region defined by the magnetic field, solidified and conveyed away from the magnetic field in solid form in a continuous process.

Identification of consensus biomarkers for predicting non-genotoxic hepatocarcinogens

PubMed Central

Huang, Shan-Han; Tung, Chun-Wei

2017-01-01

The assessment of non-genotoxic hepatocarcinogens (NGHCs) is currently relying on two-year rodent bioassays. Toxicogenomics biomarkers provide a potential alternative method for the prioritization of NGHCs that could be useful for risk assessment. However, previous studies using inconsistently classified chemicals as the training set and a single microarray dataset concluded no consensus biomarkers. In this study, 4 consensus biomarkers of A2m, Ca3, Cxcl1, and Cyp8b1 were identified from four large-scale microarray datasets of the one-day single maximum tolerated dose and a large set of chemicals without inconsistent classifications. Machine learning techniques were subsequently applied to develop prediction models for NGHCs. The final bagging decision tree models were constructed with an average AUC performance of 0.803 for an independent test. A set of 16 chemicals with controversial classifications were reclassified according to the consensus biomarkers. The developed prediction models and identified consensus biomarkers are expected to be potential alternative methods for prioritization of NGHCs for further experimental validation. PMID:28117354

(Ultra) High Pressure Homogenization for Continuous High Pressure Sterilization of Pumpable Foods – A Review

PubMed Central

Georget, Erika; Miller, Brittany; Callanan, Michael; Heinz, Volker; Mathys, Alexander

2014-01-01

Bacterial spores have a strong resistance to both chemical and physical hurdles and create a risk for the food industry, which has been tackled by applying high thermal intensity treatments to sterilize food. These strong thermal treatments lead to a reduction of the organoleptic and nutritional properties of food and alternatives are actively searched for. Innovative hurdles offer an alternative to inactivate bacterial spores. In particular, recent technological developments have enabled a new generation of high pressure homogenizer working at pressures up to 400 MPa and thus, opening new opportunities for high pressure sterilization of foods. In this short review, we summarize the work conducted on (ultra) high pressure homogenization (U)HPH to inactivate endospores in model and food systems. Specific attention is given to process parameters (pressure, inlet, and valve temperatures). This review gathers the current state of the art and underlines the potential of UHPH sterilization of pumpable foods while highlighting the needs for future work. PMID:25988118

Peptidic tools applied to redirect alternative splicing events.

PubMed

Nancy, Martínez-Montiel; Nora, Rosas-Murrieta; Rebeca, Martínez-Contreras

2015-05-01

Peptides are versatile and attractive biomolecules that can be applied to modulate genetic mechanisms like alternative splicing. In this process, a single transcript yields different mature RNAs leading to the production of protein isoforms with diverse or even antagonistic functions. During splicing events, errors can be caused either by mutations present in the genome or by defects or imbalances in regulatory protein factors. In any case, defects in alternative splicing have been related to several genetic diseases including muscular dystrophy, Alzheimer's disease and cancer from almost every origin. One of the most effective approaches to redirect alternative splicing events has been to attach cell-penetrating peptides to oligonucleotides that can modulate a single splicing event and restore correct gene expression. Here, we summarize how natural existing and bioengineered peptides have been applied over the last few years to regulate alternative splicing and genetic expression. Under different genetic and cellular backgrounds, peptides have been shown to function as potent vehicles for splice correction, and their therapeutic benefits have reached clinical trials and patenting stages, emphasizing the use of regulatory peptides as an exciting therapeutic tool for the treatment of different genetic diseases. Copyright © 2015 Elsevier Inc. All rights reserved.

Imaging transcranial direct current stimulation (tDCS) of the prefrontal cortex-correlation or causality in stimulation-mediated effects?

PubMed

Wörsching, Jana; Padberg, Frank; Ertl-Wagner, Birgit; Kumpf, Ulrike; Kirsch, Beatrice; Keeser, Daniel

2016-10-01

Transcranial current stimulation approaches include neurophysiologically distinct non-invasive brain stimulation techniques widely applied in basic, translational and clinical research: transcranial direct current stimulation (tDCS), oscillating transcranial direct current stimulation (otDCS), transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS). Prefrontal tDCS seems to be an especially promising tool for clinical practice. In order to effectively modulate relevant neural circuits, systematic research on prefrontal tDCS is needed that uses neuroimaging and neurophysiology measures to specifically target and adjust this method to physiological requirements. This review therefore analyses the various neuroimaging methods used in combination with prefrontal tDCS in healthy and psychiatric populations. First, we provide a systematic overview on applications, computational models and studies combining neuroimaging or neurophysiological measures with tDCS. Second, we categorise these studies in terms of their experimental designs and show that many studies do not vary the experimental conditions to the extent required to demonstrate specific relations between tDCS and its behavioural or neurophysiological effects. Finally, to support best-practice tDCS research we provide a methodological framework for orientation among experimental designs. Copyright © 2016 Elsevier Ltd. All rights reserved.

Effect of Unmodulated 5-kHz Alternating Currents Versus Transcutaneous Electrical Nerve Stimulation on Mechanical and Thermal Pain, Tactile Threshold, and Peripheral Nerve Conduction: A Double-Blind, Placebo-Controlled Crossover Trial.

PubMed

Avendaño-Coy, Juan; Gómez-Soriano, Julio; Goicoechea-García, Carlos; Basco-López, Julian Angel; Taylor, Julian

2017-05-01

To investigate the effect of unmodulated 5-kHz alternating current on mechanical pain threshold (MPT), heat pain threshold (HPT), tactile threshold (TT), and peripheral nerve conduction (PNC) compared with transcutaneous electrical nerve stimulation (TENS) and sham stimulation. National referral center. Randomized, double-blind, placebo-controlled crossover trial. Healthy volunteers (N=38). No dropouts or adverse events were reported. TENS, unmodulated 5-kHz currents, and sham stimulation were applied on the radial nerve for 20 minutes with a 24-hour washout period between them and concealed intervention allocation. Four measures were taken: before, during, and 2 after the interventions. Algometry was used to assess MPT, a Peltier thermode for HPT using the method of limits, Von Frey filaments for TT, and radial nerve compound action potential. No differences were observed on MPT, HPT, and PNC when 5-kHz current and TENS were compared. However, TT increased 56.2mN (95% confidence interval [CI], 28.8-83.6) in the TENS group compared with the 5-kHz current group during intervention. Compared with sham stimulation during intervention, MPT increased 4.7N (95% CI, 0.3-9.2) using 5-kHz current and 10.4N (95% CI, 3.5-17.3) with TENS. TT increased 17.2mN (95% CI, 4.7-29.7) with 5-kHz current and 73.4mN (95% CI, 47.5-99.2) with TENS. However, HPT increased 1.0°C (95% CI, 0.2-2.0) only with TENS. For the PNC, no differences were found among the 3 groups. Unmodulated 5-kHz current produced an increase in somatosensory thresholds that was greater than placebo but not when compared with TENS; however, participants perceived 5-kHz currents to be more comfortable and showed more habituation to them. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Numerical modelling of dynamic resistance in high-temperature superconducting coated-conductor wires

NASA Astrophysics Data System (ADS)

Ainslie, Mark D.; Bumby, Chris W.; Jiang, Zhenan; Toyomoto, Ryuki; Amemiya, Naoyuki

2018-07-01

The use of superconducting wire within AC power systems is complicated by the dissipative interactions that occur when a superconductor is exposed to an alternating current and/or magnetic field, giving rise to a superconducting AC loss caused by the motion of vortices within the superconducting material. When a superconductor is exposed to an alternating field whilst carrying a constant DC transport current, a DC electrical resistance can be observed, commonly referred to as ‘dynamic resistance.’ Dynamic resistance is relevant to many potential high-temperature superconducting (HTS) applications and has been identified as critical to understanding the operating mechanism of HTS flux pump devices. In this paper, a 2D numerical model based on the finite-element method and implementing the H -formulation is used to calculate the dynamic resistance and total AC loss in a coated-conductor HTS wire carrying an arbitrary DC transport current and exposed to background AC magnetic fields up to 100 mT. The measured angular dependence of the superconducting properties of the wire are used as input data, and the model is validated using experimental data for magnetic fields perpendicular to the plane of the wire, as well as at angles of 30° and 60° to this axis. The model is used to obtain insights into the characteristics of such dynamic resistance, including its relationship with the applied current and field, the wire’s superconducting properties, the threshold field above which dynamic resistance is generated and the flux-flow resistance that arises when the total driven transport current exceeds the field-dependent critical current, I c( B ), of the wire. It is shown that the dynamic resistance can be mostly determined by the perpendicular field component with subtle differences determined by the angular dependence of the superconducting properties of the wire. The dynamic resistance in parallel fields is essentially negligible until J c is exceeded and flux-flow resistance occurs.

Experimental validation of the dual positive and negative ion beam acceleration in the plasma propulsion with electronegative gases thruster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rafalskyi, Dmytro, E-mail: dmytro.rafalskyi@lpp.polytechnique.fr; Popelier, Lara; Aanesland, Ane

The PEGASES (Plasma Propulsion with Electronegative Gases) thruster is a gridded ion thruster, where both positive and negative ions are accelerated to generate thrust. In this way, additional downstream neutralization by electrons is redundant. To achieve this, the thruster accelerates alternately positive and negative ions from an ion-ion plasma where the electron density is three orders of magnitude lower than the ion densities. This paper presents a first experimental study of the alternate acceleration in PEGASES, where SF{sub 6} is used as the working gas. Various electrostatic probes are used to investigate the source plasma potential and the energy, composition,more » and current of the extracted beams. We show here that the plasma potential control in such system is key parameter defining success of ion extraction and is sensitive to both parasitic electron current paths in the source region and deposition of sulphur containing dielectric films on the grids. In addition, large oscillations in the ion-ion plasma potential are found in the negative ion extraction phase. The oscillation occurs when the primary plasma approaches the grounded parts of the main core via sub-millimetres technological inputs. By controlling and suppressing the various undesired effects, we achieve perfect ion-ion plasma potential control with stable oscillation-free operation in the range of the available acceleration voltages (±350 V). The measured positive and negative ion currents in the beam are about 10 mA for each component at RF power of 100 W and non-optimized extraction system. Two different energy analyzers with and without magnetic electron suppression system are used to measure and compare the negative and positive ion and electron fluxes formed by the thruster. It is found that at alternate ion-ion extraction the positive and negative ion energy peaks are similar in areas and symmetrical in position with +/− ion energy corresponding to the amplitude of the applied acceleration voltage.« less

Economic Analysis of Classical Swine Fever Surveillance in the Netherlands.

PubMed

Guo, X; Claassen, G D H; Oude Lansink, A G J M; Loeffen, W; Saatkamp, H W

2016-06-01

Classical swine fever (CSF) is a highly contagious pig disease that causes economic losses and impaired animal welfare. Improving the surveillance system for CSF can help to ensure early detection of the virus, thereby providing a better initial situation for controlling the disease. Economic analysis is required to compare the benefits of improved surveillance with the costs of implementing a more intensive system. This study presents a comprehensive economic analysis of CSF surveillance in the Netherlands, taking into account the specialized structure of Dutch pig production, differences in virulence of CSF strains and a complete list of possible surveillance activities. The starting point of the analysis is the current Dutch surveillance system (i.e. the default surveillance-setup scenario), including the surveillance activities 'daily clinical observation by the farmer', 'veterinarian inspection after a call', 'routine veterinarian inspection', 'pathology in AHS', 'PCR on tonsil in AHS', 'PCR on grouped animals in CVI' and 'confirmatory PCR by NVWA'. Alternative surveillance-setup scenarios were proposed by adding 'routine serology in slaughterhouses', 'routine serology on sow farms' and 'PCR on rendered animals'. The costs and benefits for applying the alternative surveillance-setup scenarios were evaluated by comparing the annual mitigated economic losses because of intensified CSF surveillance with the annual additional surveillance costs. The results of the cost-effectiveness analysis show that the alternative surveillance-setup scenarios with 'PCR on rendered animals' are effective for the moderately virulent CSF strain, whereas the scenarios with 'routine serology in slaughterhouses' or 'routine serology on sow farms' are effective for the low virulent strain. Moreover, the current CSF surveillance system in the Netherlands is cost-effective for both moderately virulent and low virulent CSF strains. The results of the cost-benefit analysis for the moderately virulent CSF strain indicate that the current surveillance system in the Netherlands is adequate. From an economic perspective, there is little to be gained from intensifying surveillance. © 2014 Blackwell Verlag GmbH.

Alternative medicine in the workplace.

PubMed

Lippin, R A

1996-01-01

Workplace settings are ripe for the application of alternative medical interventions for a variety of reasons. Included among them are a shared interest in prevention by both the occupational and alternative medicine communities, economic incentives by corporations as major purchasers of healthcare to reduce healthcare costs and improve employee productivity, and the willingness of corporations to be differentially creative in their approach to delivering and purchasing healthcare. This paper describes the US workforce in transition, provides an overview of occupational medicine including current programs and emerging issues, describes the current applications of alternative medicine interventions in the workplace, and argues for future expanded application of alternative medicine in workplace settings.

Learning general phonological rules from distributional information: a computational model.

PubMed

Calamaro, Shira; Jarosz, Gaja

2015-04-01

Phonological rules create alternations in the phonetic realizations of related words. These rules must be learned by infants in order to identify the phonological inventory, the morphological structure, and the lexicon of a language. Recent work proposes a computational model for the learning of one kind of phonological alternation, allophony (Peperkamp, Le Calvez, Nadal, & Dupoux, 2006). This paper extends the model to account for learning of a broader set of phonological alternations and the formalization of these alternations as general rules. In Experiment 1, we apply the original model to new data in Dutch and demonstrate its limitations in learning nonallophonic rules. In Experiment 2, we extend the model to allow it to learn general rules for alternations that apply to a class of segments. In Experiment 3, the model is further extended to allow for generalization by context; we argue that this generalization must be constrained by linguistic principles. Copyright © 2014 Cognitive Science Society, Inc.

30 CFR 75.524 - Electric face equipment; electric equipment used in return air outby the last open crosscut...

Code of Federal Regulations, 2010 CFR

2010-07-01

... current between frames of equipment. 75.524 Section 75.524 Mineral Resources MINE SAFETY AND HEALTH... the last open crosscut; maximum level of alternating or direct electric current between frames of equipment. The maximum level of alternating or direct electric current that exists between the frames of any...

Adjuncts to colonic cleansing before colonoscopy.

PubMed

Park, Sanghoon; Lim, Yun Jeong

2014-03-21

Pre-procedural cleansing of the bowel can maximize the effectiveness and efficiency of colonoscopy. Yet, efficacy of the current gold standard colonic preparation method - high-volume oral administration of purgative agents 12-24 h prior to the procedure - is limited by several factors, such as patient compliance (due to poor palatability and inconvenience of the dosing regimen) and risks of complications (due to drug interactions or intolerance). Attempts to resolve these limitations have included providing adjunctive agents and methods to promote the colonic cleansing ability of the principal purgative agent, with the aim of lessening unpleasant side effects (such as bloating) and reducing the large ingested volume requirement. Several promising adjunctive agents are bisacodyl, magnesium citrate, senna, simethicone, metoclopramide, and prokinetics, and each are being investigated for their potential. This review provides an up to date summary of the reported investigations into the potencies and weaknesses of the key adjuncts currently being applied in clinic as supplements to the traditional bowel preparation agents. While the comparative analysis of these adjuncts showed that no single agent or method has yet achieved the goal of completely overcoming the limitations of the current gold standard preparation method, they at least provide endoscopists with an array of alternatives to help improve the suboptimal efficacy of the main cleansing solutions when used alone. To aid in this clinical endeavor, a subjective grade was assigned to each adjunct to indicate its practical value. In addition, the systematic review of the currently available agents and methods provides insight into the features of each that may be overcome or exploited to create novel drugs and strategies that may become adopted as effective bowel cleansing adjuncts or alternatives.

Adjuncts to colonic cleansing before colonoscopy

PubMed Central

Park, Sanghoon; Lim, Yun Jeong

2014-01-01

Pre-procedural cleansing of the bowel can maximize the effectiveness and efficiency of colonoscopy. Yet, efficacy of the current gold standard colonic preparation method - high-volume oral administration of purgative agents 12-24 h prior to the procedure - is limited by several factors, such as patient compliance (due to poor palatability and inconvenience of the dosing regimen) and risks of complications (due to drug interactions or intolerance). Attempts to resolve these limitations have included providing adjunctive agents and methods to promote the colonic cleansing ability of the principal purgative agent, with the aim of lessening unpleasant side effects (such as bloating) and reducing the large ingested volume requirement. Several promising adjunctive agents are bisacodyl, magnesium citrate, senna, simethicone, metoclopramide, and prokinetics, and each are being investigated for their potential. This review provides an up to date summary of the reported investigations into the potencies and weaknesses of the key adjuncts currently being applied in clinic as supplements to the traditional bowel preparation agents. While the comparative analysis of these adjuncts showed that no single agent or method has yet achieved the goal of completely overcoming the limitations of the current gold standard preparation method, they at least provide endoscopists with an array of alternatives to help improve the suboptimal efficacy of the main cleansing solutions when used alone. To aid in this clinical endeavor, a subjective grade was assigned to each adjunct to indicate its practical value. In addition, the systematic review of the currently available agents and methods provides insight into the features of each that may be overcome or exploited to create novel drugs and strategies that may become adopted as effective bowel cleansing adjuncts or alternatives. PMID:24659864

30 CFR 75.900-4 - Testing, examination, and maintenance of circuit breakers; record.

Code of Federal Regulations, 2011 CFR

2011-07-01

... circuits serving three-phase alternating current equipment used in the mine. Such record shall be kept in a... Underground Low- and Medium-Voltage Alternating Current Circuits § 75.900-4 Testing, examination, and...

30 CFR 75.900-4 - Testing, examination, and maintenance of circuit breakers; record.

Code of Federal Regulations, 2010 CFR

2010-07-01

... circuits serving three-phase alternating current equipment used in the mine. Such record shall be kept in a... Underground Low- and Medium-Voltage Alternating Current Circuits § 75.900-4 Testing, examination, and...

ASSESSING ALTERNATIVE FUTURES FOR AGRICULTURE IN IOWA, U.S.A.

EPA Science Inventory

The contributions of current industrial agricultural practices to environmental degradation and the social problems facing agricultural regions are well known. However, landscape-scale alternatives to current conditions have not been fully explored nor their potential impacts qua...

System and method of adjusting the equilibrium temperature of an inductively-heated susceptor

DOEpatents

Matsen, Marc R; Negley, Mark A; Geren, William Preston

2015-02-24

A system for inductively heating a workpiece may include an induction coil, at least one susceptor face sheet, and a current controller coupled. The induction coil may be configured to conduct an alternating current and generate a magnetic field in response to the alternating current. The susceptor face sheet may be configured to have a workpiece positioned therewith. The susceptor face sheet may be formed of a ferromagnetic alloy having a Curie temperature and being inductively heatable to an equilibrium temperature approaching the Curie temperature in response to the magnetic field. The current controller may be coupled to the induction coil and may be configured to adjust the alternating current in a manner causing a change in at least one heating parameter of the susceptor face sheet.

Method For Chemical Sensing Using A Microfabricated Teeter-Totter Resonator

DOEpatents

Adkins, Douglas Ray; Heller, Edwin J.; Shul, Randy J.

2004-11-30

A method for sensing a chemical analyte in a fluid stream comprises providing a microfabricated teeter-totter resonator that relies upon a Lorentz force to cause oscillation in a paddle, applying a static magnetic field substantially aligned in-plane with the paddle, energizing a current conductor line on a surface of the paddle with an alternating electrical current to generate the Lorentz force, exposing the resonator to the analyte, and detecting the response of the oscillatory motion of the paddle to the chemical analyte. Preferably, a chemically sensitive coating is disposed on at least one surface of the paddle to enhance the sorption of the analyte by the paddle. The concentration of the analyte in a fluid stream can be determined by measuring the change in the resonant frequency or phase of the teeter-totter resonator as the chemical analyte is added to or removed from the paddle.

A voltage-controlled capacitive discharge method for electrical activation of peripheral nerves.

PubMed

Rosellini, Will M; Yoo, Paul B; Engineer, Navzer; Armstrong, Scott; Weiner, Richard L; Burress, Chester; Cauller, Larry

2011-01-01

A voltage-controlled capacitive discharge (VCCD) method was investigated as an alternative to rectangular stimulus pulses currently used in peripheral nerve stimulation therapies.  In two anesthetized Gottingen mini pigs, the threshold (total charge per phase) for evoking a compound nerve action potential (CNAP) was compared between constant current (CC) and VCCD methods. Electrical pulses were applied to the tibial and posterior cutaneous femoralis nerves using standard and modified versions of the Medtronic 3778 Octad.  In contrast to CC stimulation, the combined application of VCCD pulses with a modified Octad resulted in a marked decrease (-73 ± 7.4%) in the stimulation threshold for evoking a CNAP. This was consistent for different myelinated fiber types and locations of stimulation.  The VCCD method provides a highly charge-efficient means of activating myelinated fibers that could potentially be used within a wireless peripheral nerve stimulator system. © 2011 International Neuromodulation Society.

Challenges to promoting health for amateur athletes through anti-doping policy.

PubMed

Henning, April

2017-01-01

Anti-doping regulations are intended, at least in part, to promote the health of athletes. While most anti-doping efforts target elite and professional competitors, there have been recent moves by sport governing bodies to expand anti-doping testing to include amateur athletes. Drawing on previous critiques of anti-doping policies and illustrating cases, this article outlines five of the challenges to health promotion of applying the current detect and ban model to the amateur level of sport. I argue that the current approach is not effective and, in some ways, may undermine the goal of health promotion at the amateur level. In order to address these challenges, I propose alternative, health-centred strategies that focus on athlete empowerment and choice through critical awareness of a variety of substances, associated risks and rewards, and the role of expertise in decision-making.

Challenges to promoting health for amateur athletes through anti-doping policy

PubMed Central

Henning, April

2017-01-01

Anti-doping regulations are intended, at least in part, to promote the health of athletes. While most anti-doping efforts target elite and professional competitors, there have been recent moves by sport governing bodies to expand anti-doping testing to include amateur athletes. Drawing on previous critiques of anti-doping policies and illustrating cases, this article outlines five of the challenges to health promotion of applying the current detect and ban model to the amateur level of sport. I argue that the current approach is not effective and, in some ways, may undermine the goal of health promotion at the amateur level. In order to address these challenges, I propose alternative, health-centred strategies that focus on athlete empowerment and choice through critical awareness of a variety of substances, associated risks and rewards, and the role of expertise in decision-making. PMID:28736489

Performance Characterization of a Solenoid-type Gas Valve for the H- Magnetron Source at FNAL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sosa, A.; Bollinger, D. S.; Karns, P. R.

2016-09-06

The magnetron-style H- ion sources currently in operation at Fermilab use piezoelectric gas valves to function. This kind of gas valve is sensitive to small changes in ambient temperature, which affect the stability and performance of the ion source. This motivates the need to find an alternative way of feeding H2 gas into the source. A solenoid-type gas valve has been characterized in a dedicated off-line test stand to assess the feasibility of its use in the operational ion sources. H- ion beams have been extracted at 35 keV using this valve. In this study, the performance of the solenoidmore » gas valve has been characterized measuring the beam current output of the magnetron source with respect to the voltage and pulse width of the signal applied to the gas valve.« less

Marshall Space Flight Center CFD overview

NASA Technical Reports Server (NTRS)

Schutzenhofer, Luke A.

1989-01-01

Computational Fluid Dynamics (CFD) activities at Marshall Space Flight Center (MSFC) have been focused on hardware specific and research applications with strong emphasis upon benchmark validation. The purpose here is to provide insight into the MSFC CFD related goals, objectives, current hardware related CFD activities, propulsion CFD research efforts and validation program, future near-term CFD hardware related programs, and CFD expectations. The current hardware programs where CFD has been successfully applied are the Space Shuttle Main Engines (SSME), Alternate Turbopump Development (ATD), and Aeroassist Flight Experiment (AFE). For the future near-term CFD hardware related activities, plans are being developed that address the implementation of CFD into the early design stages of the Space Transportation Main Engine (STME), Space Transportation Booster Engine (STBE), and the Environmental Control and Life Support System (ECLSS) for the Space Station. Finally, CFD expectations in the design environment will be delineated.

Microalgal cultivation with biogas slurry for biofuel production.

PubMed

Zhu, Liandong; Yan, Cheng; Li, Zhaohua

2016-11-01

Microalgal growth requires a substantial amount of chemical fertilizers. An alternative to the utilization of fertilizer is to apply biogas slurry produced through anaerobic digestion to cultivate microalgae for the production of biofuels. Plenty of studies have suggested that anaerobic digestate containing high nutrient contents is a potentially feasible nutrient source to culture microalgae. However, current literature indicates a lack of review available regarding microalgal cultivation with biogas slurry for the production of biofuels. To help fill this gap, this review highlights the integration of digestate nutrient management with microalgal production. It first unveils the current status of microalgal production, providing basic background to the topic. Subsequently, microalgal cultivation technologies using biogas slurry are discussed in detail. A scale-up scheme for simultaneous biogas upgrade and digestate application through microalgal cultivation is then proposed. Afterwards, several uncertainties that might affect this practice are explored. Finally, concluding remarks are put forward. Copyright © 2016 Elsevier Ltd. All rights reserved.

[Research and Post-graduate in Psychiatry].

PubMed

Carlos, A Palacio A

2012-01-01

The research component and the acquisition of skills related to the generation of knowledge in the training of medical and surgical specialists in the country is an issue that has recently begun to be discussed. For over 50 years this training has included only the area of professionalism as a copy of an educational model from the mid-twentieth century. Currently the country requires specialists with critical and analytical skills to question their actions and knowledge and generate alternative clinical care to apply to the general population in the search of bettering their own welfare. This article is a review in which the current situation of the teaching of psychiatry and the inclusion of research in the academic processes of our medical specialties in the country are analyzed. Copyright © 2012 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

Analysis Insights, August 2015: Sustainable Transportation; NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2015-08-01

NREL Analysis Insights mines our body of analysis work to synthesize topical insights and key findings. In this issue, we examine transportation systems, alternative fuels, and implications of increasing electrification of transit. Moving people and goods from point A to B has never been easier, but our current transportation systems also take a toll on our environment. Transportation currently accounts for 71% of total U.S. petroleum use and 33% of the nation’s total carbon emissions. With new technology, can we make our transportation system cleaner and more cost effective? NREL is applying its analytical expertise and imagination to do justmore » that. Solutions start with systems thinking. Connecting the dots between physical components - vehicles, fueling stations, and highways - and institutional components - traffic laws, regulations, and vehicle standards - helps illuminate solutions that address the needs of the transportation system's many stakeholders.« less

CORRECTIVE ACTION DECISION DOCUMENT FOR CORRECTIVE ACTION UNIT 383: AREA 12 E-TUNNEL SITES, NEVADA TEST SITE, REV. NO. 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mark McLane

2005-03-01

This Corrective Action Decision Document (CADD) was prepared by the Defense Threat Reduction Agency (DTRA) and the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO). The recommendations and corrective actions described within this document apply to the future closure of Corrective Action Unit (CAU) 383, Area 12 E-Tunnel Sites, which is a joint DTRA and NNSA/NSO site. The CAU consists of three (3) Corrective Action Sites (CASs): CAS 12-06-06 (Muckpile); CAS 12-25-02 (Oil Spill); and CAS 12-28-02 (Radioactive Material). In addition to these CASs, E-Tunnel Ponds One, Two, and Three, and the Drainage Area above themore » ponds were included since closure of the Muckpile will impact these areas. This CADD is consistent with the requirements of the ''Federal Facility Agreement and Consent Order'' agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. The DTRA point of contact is the Nevada Operations Office, Environmental Project Manager; currently Ms. Tiffany A. Lantow. The NNSA/NSO point of contact is the Environmental Restoration, Industrial Sites Project Manager; currently Ms. Janet Appenzeller-Wing. The purpose of this CADD is to identify and provide the rationale for the selection of a recommended corrective action alternative for CAU 383. This document presents the recommended corrective action for CAU 383 (E-Tunnel Sites); however, implementation may be affected by the corrective action (to be determined) for CAU 551 (Area 12 Muckpiles) due to the close proximity of B, C, D, and F-Tunnels. The scope of this CADD consists of the following tasks: (1) Develop corrective action objectives; (2) Identify corrective action alternative screening criteria; (3) Develop corrective action alternatives; (4) Perform detailed and comparative evaluations of the corrective action alternatives in relation to the corrective action objectives and screening criteria; and (5) Recommend and justify a preferred corrective action alternative for CAU 383.« less

Uranium-Loaded Water Treatment Resins: 'Equivalent Feed' at NRC and Agreement State-Licensed Uranium Recovery Facilities - 12094

DOE Office of Scientific and Technical Information (OSTI.GOV)

Camper, Larry W.; Michalak, Paul; Cohen, Stephen

Community Water Systems (CWSs) are required to remove uranium from drinking water to meet EPA standards. Similarly, mining operations are required to remove uranium from their dewatering discharges to meet permitted surface water discharge limits. Ion exchange (IX) is the primary treatment strategy used by these operations, which loads uranium onto resin beads. Presently, uranium-loaded resin from CWSs and mining operations can be disposed as a waste product or processed by NRC- or Agreement State-licensed uranium recovery facilities if that licensed facility has applied for and received permission to process 'alternate feed'. The disposal of uranium-loaded resin is costly andmore » the cost to amend a uranium recovery license to accept alternate feed can be a strong disincentive to commercial uranium recovery facilities. In response to this issue, the NRC issued a Regulatory Issue Summary (RIS) to clarify the agency's policy that uranium-loaded resin from CWSs and mining operations can be processed by NRC- or Agreement State-licensed uranium recovery facilities without the need for an alternate feed license amendment when these resins are essentially the same, chemically and physically, to resins that licensed uranium recovery facilities currently use (i.e., equivalent feed). NRC staff is clarifying its current alternate feed policy to declare IX resins as equivalent feed. This clarification is necessary to alleviate a regulatory and financial burden on facilities that filter uranium using IX resin, such as CWSs and mine dewatering operations. Disposing of those resins in a licensed facility could be 40 to 50 percent of the total operations and maintenance (O and M) cost for a CWS. Allowing uranium recovery facilities to treat these resins without requiring a license amendment lowers O and M costs and captures a valuable natural resource. (authors)« less

Allele-Specific Alternative mRNA processing (ASARP) | Informatics Technology for Cancer Research (ITCR)

Cancer.gov

A software pipeline for prediction of allele-specific alternative RNA processing events using single RNA-seq data. The current version focuses on prediction of alternative splicing and alternative polyadenylation modulated by genetic variants.

Actinide targets for fundamental research in nuclear physics

NASA Astrophysics Data System (ADS)

Eberhardt, K.; Düllmann, Ch. E.; Haas, R.; Mokry, Ch.; Runke, J.; Thörle-Pospiech, P.; Trautmann, N.

2018-05-01

Thin actinide layers deposited on various substrates are widely used as calibration sources in nuclear spectroscopy. Other applications include fundamental research in nuclear chemistry and -physics, e.g., the chemical and physical properties of super-heavy elements (SHE, Z > 103) or nuclear reaction studies with heavy ions. For the design of future nuclear reactors like fast-fission reactors and accelerator-driven systems for transmutation of nuclear waste, precise data for neutron absorption as well as neutron-induced fission cross section data for 242Pu with neutrons of different energies are of particular importance, requiring suitable Pu-targets. Another application includes studies of nuclear transitions in 229Th harvested as α-decay recoil product from a thin layer of its 233U precursor. For this, a thin and very smooth layer of 233U is used. We report here on the production of actinide layers mostly obtained by Molecular Plating (MP). MP is currently the only fabrication method in cases where the desired actinide material is available only in very limited amounts or possesses a high specific activity. Here, deposition is performed from organic solution applying a current density of 1-2 mA/cm2. Under these conditions target thicknesses of 500-1000 μg/cm2 are possible applying a single deposition step with deposition yields approaching 100 %. For yield determination α-particle spectroscopy, γ-spectroscopy and Neutron Activation Analysis is routinely used. Layer homogeneity is checked with Radiographic Imaging. As an alternative technique to MP the production of thin lanthanide and actinide layers by the so-called "Drop on Demand"-technique applied e.g., in ink-jet printing is currently under investigation.

Potential Alternatives Report for Validation of Alternative Low-Emission Surface PreparationlDepainting Technologies for Structural Steel

NASA Technical Reports Server (NTRS)

Lewis, Pattie

2006-01-01

For this project, particulates and solvents used during the depainting process of steel structures were the identified hazardous material (HazMat) targeted for elimination or reduction. This Potential Alternatives Report (PAR) provides technical analyses of identified alternatives to the current coating removal processes, criteria used to select alternatives for further analysis, and a list of those alternatives recommended for testing. The initial coating removal alternatives list was compiled using literature searches and center participant recommendations. The involved project participants initially considered fifteen (15) alternatives. In late 2004, stakeholders down-selected the list and identified specific processes as potential alternatives to the current depainting methods. The selected alternatives were: 1. Plastic Blast Media 2. Hard Abrasive Media 3. Sponge Blast Media 4. Mechanical Removal with Vacuum Attachment 5. Liquid Nitrogen 6. Laser Coating Removal Available information about these processes was used to analyze the technical merits and the potential environmental, safety, and occupational health (ESOH) impacts of these methods. A preliminary cost benefit analysis will be performed to determine if implementation of alternative technologies is economically justified. NASA AP2

Pollution Prevention Benefits Manual: Phase II. Volume 1: The Manual and Volume 2: Appendices (1989)

EPA Pesticide Factsheets

Manual is intended to help polluters evaluate the economic feasibility of pollution prevention or waste minimization alternatives to current practices, helping polluters evaluate how much a pollution prevention alternative will cost vs. current practices.

40 CFR 86.347-79 - Alternative calculations for diesel engines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Alternative calculations for diesel... Emission Regulations for New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.347-79 Alternative calculations for diesel engines. (a) This section applies to Diesel...

40 CFR 86.347-79 - Alternative calculations for diesel engines.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Alternative calculations for diesel... Emission Regulations for New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.347-79 Alternative calculations for diesel engines. (a) This section applies to Diesel...

Alternative Certification Isn't Alternative

ERIC Educational Resources Information Center

Walsh, Kate; Jacobs, Sandi

2007-01-01

While nearly all states now have something on their books labeled "alternate route to certification," these programs defy standard definition due to their enormous variability. States differ in the types of candidates allowed to apply (e.g., career changers or recent college graduates) and in the academic backgrounds these individuals must…

Nanoscale Electronic Conditioning for Improvement of Nanowire Light-Emitting-Diode Efficiency.

PubMed

May, Brelon J; Belz, Matthew R; Ahamed, Arshad; Sarwar, A T M G; Selcu, Camelia M; Myers, Roberto C

2018-04-24

Commercial III-Nitride LEDs and lasers spanning visible and ultraviolet wavelengths are based on epitaxial films. Alternatively, nanowire-based III-Nitride optoelectronics offer the advantage of strain compliance and high crystalline quality growth on a variety of inexpensive substrates. However, nanowire LEDs exhibit an inherent property distribution, resulting in uneven current spreading through macroscopic devices that consist of millions of individual nanowire diodes connected in parallel. Despite being electrically connected, only a small fraction of nanowires, sometimes <1%, contribute to the electroluminescence (EL). Here, we show that a population of electrical shorts exists in the devices, consisting of a subset of low-resistance nanowires that pass a large portion of the total current in the ensemble devices. Burn-in electronic conditioning is performed by applying a short-term overload voltage; the nanoshorts experience very high current density, sufficient to render them open circuits, thereby forcing a new current path through more nanowire LEDs in an ensemble device. Current-voltage measurements of individual nanowires are acquired using conductive atomic force microscopy to observe the removal of nanoshorts using burn-in. In macroscopic devices, this results in a 33× increase in peak EL and reduced leakage current. Burn-in conditioning of nanowire ensembles therefore provides a straightforward method to mitigate nonuniformities inherent to nanowire devices.

Adolescent cigarette smokers' and non-cigarette smokers' use of alternative tobacco products.

PubMed

Saunders, Charles; Geletko, Karen

2012-08-01

This study uses the most recent data from the nationally representative National Youth Tobacco Survey (NYTS) to examine the use of alternative tobacco products among U.S. cigarette smokers and non-cigarette smokers aged 14-17. Alternative tobacco product use is defined as use of one or more of the following products: smokeless tobacco, cigars, pipes, bidis, or kreteks. Using the results from the 2004, 2006, and 2009 NYTS, multivariate logistic regressions were used to investigate separately the extent of alternative tobacco product use in current cigarette smokers and in those who reported not smoking cigarettes controlling for demographic and other independent influences. The results indicate that for adolescent smokers and nonsmokers, the use of one type of alternative tobacco product made it much more likely the individual would use one or more of the other alternative tobacco products. Non-cigarette smokers using these tobacco products appeared to exhibit symptoms of nicotine dependence comparable to those of cigarette smokers. More information on adolescent use of alternative tobacco products is needed. Current cigarette use declined 3.4% annually over 2004-2009 for the NYTS 14- to 17-year-old population, but this cohort's use of alternative tobacco products was unchanged. The number of adolescents aged 14-17 who did not smoke cigarettes but used alternative tobacco products increased 5.9% per year over the same period. Current surveillance measures need to be expanded in order to gain a more comprehensive understanding of adolescent alternative tobacco use.

Net current control device. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fugate, D.; Cooper, J.H.

1998-11-01

Net currents generally result in elevated magnetic fields because the alternate paths are distant from the circuit conductors. Investigations have shown that one of the primary sources of power frequency magnetic fields in residential buildings is currents that return to their source via paths other than the neutral conductors. As part of EPRI`s Magnetic Field Shielding Project, ferromagnetic devices, called net current control (NCC) devices, were developed and tested for use in reducing net currents on electric power cables and the resulting magnetic fields. Applied to a residential service drop, an NCC device reduces net current by forcing current offmore » local non-utility ground paths, and back onto the neutral conductor. Circuit models and basic design equations for the NCC concept were developed, and proof-of-principles tests were carried out on an actual residence with cooperation from the local utility. After proving the basic concepts, three prototype NCC devices were built and tested on a simulated neighborhood power system. Additional prototypes were built for testing by interested EPRI utility members. Results have shown that the NCC prototypes installed on residential service drops reduce net currents to milliampere levels with compromising the safety of the ground system. Although the focus was on application to residential service cables, the NCC concept is applicable to single-phase and three-phase distribution systems as well.« less

26 CFR 1.904(b)-2 - Special rules for application of section 904(b) to alternative minimum tax foreign tax credit.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) to alternative minimum tax foreign tax credit. 1.904(b)-2 Section 1.904(b)-2 Internal Revenue... alternative minimum tax foreign tax credit. (a) Application of section 904(b)(2)(B) adjustments. Section 904(b)(2)(B) shall apply for purposes of determining the alternative minimum tax foreign tax credit under...

Force analysis of magnetic bearings with power-saving controls

NASA Technical Reports Server (NTRS)

Johnson, Dexter; Brown, Gerald V.; Inman, Daniel J.

1992-01-01

Most magnetic bearing control schemes use a bias current with a superimposed control current to linearize the relationship between the control current and the force it delivers. For most operating conditions, the existence of the bias current requires more power than alternative methods that do not use conventional bias. Two such methods are examined which diminish or eliminate bias current. In the typical bias control scheme it is found that for a harmonic control force command into a voltage limited transconductance amplifier, the desired force output is obtained only up to certain combinations of force amplitude and frequency. Above these values, the force amplitude is reduced and a phase lag occurs. The power saving alternative control schemes typically exhibit such deficiencies at even lower command frequencies and amplitudes. To assess the severity of these effects, a time history analysis of the force output is performed for the bias method and the alternative methods. Results of the analysis show that the alternative approaches may be viable. The various control methods examined were mathematically modeled using nondimensionalized variables to facilitate comparison of the various methods.

Eddy currents in the measurement of magnetic susceptibility of rocks

NASA Astrophysics Data System (ADS)

Ježek, Josef; Hrouda, František

2018-01-01

The in-phase and out-of-phase susceptibility of rocks is determined by the magnetic permeability of minerals, their viscous relaxation, and by eddy currents in electrically conductive minerals induced by the applied field. The last effect has been modelled by analytical solution of Maxwell equations for a conductive sphere immersed in a homogeneous, non-conductive medium with given permeability, in presence of an alternating field. The solution is a complex function of parameters describing the sphere (its size, conductivity and permeability), surrounding medium (permeability) and applied field (frequency). Without numerical evaluations, it is difficult to distinguish in-phase and out-of-phase (OPS) susceptibility. In this paper, approximate equations are derived for both susceptibility components, which depend only on the permeability contrast between the sphere and the surrounding medium, and the skin ratio, defined as the ratio between sphere radius and skin depth of the induced currents. These equations are used to obtain a systematic assessment of the role of electrical conductivity in determining the susceptibility of rock samples. The contribution of eddy currents to the susceptibility of diluted (<5%) magnetite particle dispersions is negligible at 1 kHz, but not at higher frequencies. Common rock-forming paramagnetic and diamagnetic minerals with weak electrical conductivity and magnetic permeability are characterized by negligible OPS at 1 kHz. Theoretically, measurable OPS and high phase angles can be produced by paramagnetic conductive minerals in certain combinations with a diamagnetic matrix. This can be excluded from practical point of view for paramagnetic minerals with susceptibilities >0.003 and conductivities not exceeding 5000 S/m.

Manual. According to the Calculation of Wires and Cables,

DTIC Science & Technology

1980-04-23

Tpezxaaaro TON. As, C Kay: (1). Designation. t2). Designation. (3). Current (permanent. Voltage constant. (4). Currant ivariable/ alternating . Voltage is the...variable/ alternating , general designatior. (5). Current variable/ alternating three-phase 5C Hz. (6). Ez. (7). Zero line (neutral). It is allcwed/assumed...diagrams of powsr supply iz is allowed/assumed high-voltage switch to dapict, as it is shown. (10). iinuings by relay, contactor and magnetic starter. It

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT XVII, LEARNING ABOUT AC GENERATOR (ALTERNATOR) PRINCIPLES (PART II).

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATING PRINCIPLES AND THE SERVICING AND TESTING PROCEDURES FOR ALTERNATING CURRENT (AC) GENERATORS AND REGULATORS USED ON DIESEL POWERED EQUIPMENT. TOPICS ARE REVIEW OF ALTERNATOR PRINCIPLES, ALTERNATOR SERVICING AND TESTING, ALTERNATOR REGULATOR OPERATING…

Electromechanical actuator with controllable motion, fast response rate, and high-frequency resonance based on graphene and polydiacetylene.

PubMed

Liang, Jiajie; Huang, Lu; Li, Na; Huang, Yi; Wu, Yingpeng; Fang, Shaoli; Oh, Jiyoung; Kozlov, Mikhail; Ma, Yanfeng; Li, Feifei; Baughman, Ray; Chen, Yongsheng

2012-05-22

Although widely investigated, novel electromechanical actuators with high overall actuation performance are still in urgent need for various practical and scientific applications, such as robots, prosthetic devices, sensor switches, and sonar projectors. In this work, combining the properties of unique environmental perturbations-actuated deformational isomerization of polydiacetylene (PDA) and the outstanding intrinsic features of graphene together for the first time, we design and fabricate an electromechanical bimorph actuator composed of a layer of PDA crystal and a layer of flexible graphene paper through a simple yet versatile solution approach. Under low applied direct current (dc), the graphene-PDA bimorph actuator with strong mechanical strength can generate large actuation motion (curvature is about 0.37 cm(-1) under a current density of 0.74 A/mm(2)) and produce high actuation stress (more than 160 MPa/g under an applied dc of only 0.29 A/mm(2)). When applying alternating current (ac), this actuator can display reversible swing behavior with long cycle life under high frequencies even up to 200 Hz; significantly, while the frequency and the value of applied ac and the state of the actuators reach an appropriate value, the graphene-PDA actuator can produce a strong resonance and the swing amplitude will jump to a peak value. Moreover, this stable graphene-PDA actuator also demonstrates rapidly and partially reversible electrochromatic phenomenon when applying an ac. Two mechanisms-the dominant one, electric-induced deformation, and a secondary one, thermal-induced expansion of PDA-are proposed to contribute to these interesting actuation performances of the graphene-PDA actuators. On the basis of these results, a mini-robot with controllable direction of motion based on the graphene-PDA actuator is designed to illustrate the great potential of our discoveries for practical use. Combining the unique actuation mechanism and many outstanding properties of graphene and PDA, this novel kind of graphene-PDA actuator exhibits compelling advantages to traditional electromechanical actuation technology and may provide a new avenue for actuation applications.

ULTRA-SHARP nonoscillatory convection schemes for high-speed steady multidimensional flow

NASA Technical Reports Server (NTRS)

Leonard, B. P.; Mokhtari, Simin

1990-01-01

For convection-dominated flows, classical second-order methods are notoriously oscillatory and often unstable. For this reason, many computational fluid dynamicists have adopted various forms of (inherently stable) first-order upwinding over the past few decades. Although it is now well known that first-order convection schemes suffer from serious inaccuracies attributable to artificial viscosity or numerical diffusion under high convection conditions, these methods continue to enjoy widespread popularity for numerical heat transfer calculations, apparently due to a perceived lack of viable high accuracy alternatives. But alternatives are available. For example, nonoscillatory methods used in gasdynamics, including currently popular TVD schemes, can be easily adapted to multidimensional incompressible flow and convective transport. This, in itself, would be a major advance for numerical convective heat transfer, for example. But, as is shown, second-order TVD schemes form only a small, overly restrictive, subclass of a much more universal, and extremely simple, nonoscillatory flux-limiting strategy which can be applied to convection schemes of arbitrarily high order accuracy, while requiring only a simple tridiagonal ADI line-solver, as used in the majority of general purpose iterative codes for incompressible flow and numerical heat transfer. The new universal limiter and associated solution procedures form the so-called ULTRA-SHARP alternative for high resolution nonoscillatory multidimensional steady state high speed convective modelling.

[Unconscious Acoustical Stimuli Effects on Event-related Potentials in Humans].

PubMed

Kopeikina, E A; Choroshich, V V; Aleksandrov, A Y; Ivanova, V Y

2015-01-01

Unconscious perception essentially affects human behavior. The main results in this area obtained in experiments with visual stimuli. However, the acoustical stimuli play not less important role in behavior. The main idea of this paper is the electroencephalographic investigation of unconscious acoustical stimulation effects on electro-physiological activity of the brain. For this purpose, the event-related potentials were acquired under unconscious stimulus priming paradigm. The one syllable, three letter length, Russian words and pseudo-words with single letter substitution were used as primes and targets. As a result, we find out that repetition and alternative priming similarly affects the event-related potential's component with 200 ms latency after target application in frontal parietal and temporal areas. Under alternative priming the direction of potential amplitude modification nearby 400 ms was altered for word and semi-word targets. Alternative priming reliably increase ERP's amplitude in 400 ms locality with pseudo-word targets and decrease it under word targets. Taking into account, that all participants were unable to distinguish the applied prime stimuli, we can assume that the event-related potential changes evoked by unconscious perception of acoustical stimuli. The ERP amplitude dynamics revealed in current investigation demonstrate the opportunity of subliminal acoustical stimuli to modulate the electrical activity evoked by verbal acoustical stimulation.

Evaluating the Performance of the IEEE Standard 1366 Method for Identifying Major Event Days

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eto, Joseph H.; LaCommare, Kristina Hamachi; Sohn, Michael D.

IEEE Standard 1366 offers a method for segmenting reliability performance data to isolate the effects of major events from the underlying year-to-year trends in reliability. Recent analysis by the IEEE Distribution Reliability Working Group (DRWG) has found that reliability performance of some utilities differs from the expectations that helped guide the development of the Standard 1366 method. This paper proposes quantitative metrics to evaluate the performance of the Standard 1366 method in identifying major events and in reducing year-to-year variability in utility reliability. The metrics are applied to a large sample of utility-reported reliability data to assess performance of themore » method with alternative specifications that have been considered by the DRWG. We find that none of the alternatives perform uniformly 'better' than the current Standard 1366 method. That is, none of the modifications uniformly lowers the year-to-year variability in System Average Interruption Duration Index without major events. Instead, for any given alternative, while it may lower the value of this metric for some utilities, it also increases it for other utilities (sometimes dramatically). Thus, we illustrate some of the trade-offs that must be considered in using the Standard 1366 method and highlight the usefulness of the metrics we have proposed in conducting these evaluations.« less

Statistical analysis of particle trajectories in living cells

NASA Astrophysics Data System (ADS)

Briane, Vincent; Kervrann, Charles; Vimond, Myriam

2018-06-01

Recent advances in molecular biology and fluorescence microscopy imaging have made possible the inference of the dynamics of molecules in living cells. Such inference allows us to understand and determine the organization and function of the cell. The trajectories of particles (e.g., biomolecules) in living cells, computed with the help of object tracking methods, can be modeled with diffusion processes. Three types of diffusion are considered: (i) free diffusion, (ii) subdiffusion, and (iii) superdiffusion. The mean-square displacement (MSD) is generally used to discriminate the three types of particle dynamics. We propose here a nonparametric three-decision test as an alternative to the MSD method. The rejection of the null hypothesis, i.e., free diffusion, is accompanied by claims of the direction of the alternative (subdiffusion or superdiffusion). We study the asymptotic behavior of the test statistic under the null hypothesis and under parametric alternatives which are currently considered in the biophysics literature. In addition, we adapt the multiple-testing procedure of Benjamini and Hochberg to fit with the three-decision-test setting, in order to apply the test procedure to a collection of independent trajectories. The performance of our procedure is much better than the MSD method as confirmed by Monte Carlo experiments. The method is demonstrated on real data sets corresponding to protein dynamics observed in fluorescence microscopy.

Enhanced distributed energy resource system

DOEpatents

Atcitty, Stanley [Albuquerque, NM; Clark, Nancy H [Corrales, NM; Boyes, John D [Albuquerque, NM; Ranade, Satishkumar J [Las Cruces, NM

2007-07-03

A power transmission system including a direct current power source electrically connected to a conversion device for converting direct current into alternating current, a conversion device connected to a power distribution system through a junction, an energy storage device capable of producing direct current connected to a converter, where the converter, such as an insulated gate bipolar transistor, converts direct current from an energy storage device into alternating current and supplies the current to the junction and subsequently to the power distribution system. A microprocessor controller, connected to a sampling and feedback module and the converter, determines when the current load is higher than a set threshold value, requiring triggering of the converter to supply supplemental current to the power transmission system.

New Approach For Prediction Groundwater Depletion

NASA Astrophysics Data System (ADS)

Moustafa, Mahmoud

2017-01-01

Current approaches to quantify groundwater depletion involve water balance and satellite gravity. However, the water balance technique includes uncertain estimation of parameters such as evapotranspiration and runoff. The satellite method consumes time and effort. The work reported in this paper proposes using failure theory in a novel way to predict groundwater saturated thickness depletion. An important issue in the failure theory proposed is to determine the failure point (depletion case). The proposed technique uses depth of water as the net result of recharge/discharge processes in the aquifer to calculate remaining saturated thickness resulting from the applied pumping rates in an area to evaluate the groundwater depletion. Two parameters, the Weibull function and Bayes analysis were used to model and analyze collected data from 1962 to 2009. The proposed methodology was tested in a nonrenewable aquifer, with no recharge. Consequently, the continuous decline in water depth has been the main criterion used to estimate the depletion. The value of the proposed approach is to predict the probable effect of the current applied pumping rates on the saturated thickness based on the remaining saturated thickness data. The limitation of the suggested approach is that it assumes the applied management practices are constant during the prediction period. The study predicted that after 300 years there would be an 80% probability of the saturated aquifer which would be expected to be depleted. Lifetime or failure theory can give a simple alternative way to predict the remaining saturated thickness depletion with no time-consuming processes such as the sophisticated software required.

Development of Alternating Current Potential Drop (ACPD) Procedures for Crack Detection in Aluminum Aircraft Panels.

DOT National Transportation Integrated Search

1993-12-01

The Alternating Current Potential Drop (ACPD) method is investigated as a means of making measurements in laboratory experiments on the initiation and growth of multiple site damage (MSD) cracks in a common aluminum alloy used for aircraft constructi...

1000 X Difference Between Current Displays and Capability of Human Visual System: Payoff Potential for Affordable Defense Systems

DTIC Science & Technology

2000-01-01

second tier technologies: digital micromirror devices (DMD); alternating current gas plasma (ACGP); inorganic electroluminescent (EL, TFEL, AMEL... Micromirror Device (DMD) - Alternating Current Gas Plasma (ACGP) - Electroluminescent (EL, TFEL, AMEL) - Vacuum Fluorescent Display (VFD) - Inorganic Light...Instruments Digital Micromirror Device (DMD) Digital Light Processing technology and another, the Qualcomm/Hughes-JVC CRT/Liquid Crystal Light Valve

Multilayered composite proton exchange membrane and a process for manufacturing the same

DOEpatents

Santurri, Pasco R; Duvall, James H; Katona, Denise M; Mausar, Joseph T; Decker, Berryinne

2015-05-05

A multilayered membrane for use with fuel cells and related applications. The multilayered membrane includes a carrier film, at least one layer of an undoped conductive polymer electrolyte material applied onto the carrier film, and at least one layer of a conductive polymer electrolyte material applied onto the adjacent layer of polymer electrolyte material. Each layer of conductive polymer electrolyte material is doped with a plurality of nanoparticles. Each layer of undoped electrolyte material and doped electrolyte material may be applied in an alternating configuration, or alternatively, adjacent layers of doped conductive polymer electrolyte material is employed. The process for producing a multilayered composite membrane includes providing a carrier substrate and solution casting a layer of undoped conductive polymer electrolyte material and a layer of conductive polymer electrolyte material doped with nanoparticles in an alternating arrangement or in an arrangement where doped layers are adjacent to one another.

Animal use replacement, reduction, and refinement: development of an integrated testing strategy for bioconcentration of chemicals in fish.

PubMed

de Wolf, Watze; Comber, Mike; Douben, Peter; Gimeno, Sylvia; Holt, Martin; Léonard, Marc; Lillicrap, Adam; Sijm, Dick; van Egmond, Roger; Weisbrod, Anne; Whale, Graham

2007-01-01

When addressing the use of fish for the environmental safety of chemicals and effluents, there are many opportunities for applying the principles of the 3Rs: Reduce, Refine, and Replace. The current environmental regulatory testing strategy for bioconcentration and secondary poisoning has been reviewed, and alternative approaches that provide useful information are described. Several approaches can be used to reduce the number of fish used in the Organization for Economic Cooperation and Development (OECD) Test Guideline 305, including alternative in vivo test methods such as the dietary accumulation test and the static exposure approach. The best replacement approach would seem to use read-across, chemical grouping, and quantitative structure-activity relationships with an assessment of the key processes in bioconcentration: Adsorption, distribution, metabolism, and excretion. Biomimetic extraction has particular usefulness in addressing bioavailable chemicals and is in some circumstances capable of predicting uptake. Use of alternative organisms such as invertebrates should also be considered. A single cut-off value for molecular weight and size beyond which no absorption will take place cannot be identified. Recommendations for their use in bioaccumulative (B) categorization schemes are provided. Assessment of biotransformation with in vitro assays and in silico approaches holds significant promise. Further research is needed to identify their variability and confidence limits and the ways to use this as a basis to estimate bioconcentration factors. A tiered bioconcentration testing strategy has been developed taking account of the alternatives discussed.

Apprenticeship, Alternance, Dual System: Dead Ends or Highways to the Future?

ERIC Educational Resources Information Center

Bertrand, Olivier; And Others

1994-01-01

In the face of chronic youth unemployment, decision makers in many countries are questioning the role and effectiveness of alternance between school-based vocational training and in-company work experience. This notion applies to three very different realities: training courses offered as an alternative to traditional school-based training for…

46 CFR 71.50-19 - The Alternative Hull Examination (AHE) Program application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false The Alternative Hull Examination (AHE) Program...) PASSENGER VESSELS INSPECTION AND CERTIFICATION Drydocking § 71.50-19 The Alternative Hull Examination (AHE... apply to the AHE Program. You must submit an application at least 90 days before the requested hull...

75 FR 49536 - Petitions for Modification of Existing Mandatory Safety Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

... alternative method of achieving the result of such standard exists which will at all times guarantee no less... for inspection; (8) the proposed alternative method will not be implemented until miners who have been... training plans will apply. The petitioner asserts that the proposed alternative method will at all times...

Alternator insulation evaluation tests

NASA Technical Reports Server (NTRS)

Penn, W. B.; Schaefer, R. F.; Balke, R. L.

1972-01-01

Tests were conducted to predict the remaining electrical insulation life of a 60 KW homopolar inductor alternator following completion of NASA turbo-alternator endurance tests for SNAP-8 space electrical power systems application. The insulation quality was established for two alternators following completion of these tests. A step-temperature aging test procedure was developed for insulation life prediction and applied to one of the two alternators. Armature winding insulation life of over 80,000 hours for an average winding temperature of 248 degrees C was predicted using the developed procedure.

Bus Propulsion Alternatives Overview

DOT National Transportation Integrated Search

1982-04-01

The Urban Mass Transportation Administration (UMTA) is currently investigating propulsion alternatives which would conserve petroleum-based fuels and would be practical for use by U.S. transit operators. A discussion of these alternatives (electric p...

Therapeutic options for acute cough due to upper respiratory infections in children.

PubMed

Paul, Ian M

2012-02-01

Cough due to upper respiratory tract infections (URIs) is one of the most frequent complaints encountered by pediatric health-care providers, and one of the most disruptive symptoms for children and families. Despite the frequency of URIs, there is limited evidence to support the few therapeutic agents currently available in the United States (US) to treat acute cough due to URI. Published, well-designed, contemporary research supporting the efficacy of narcotics (codeine, hydrocodone) and US Food and Drug Administration (FDA)-approved over-the-counter (OTC) oral antitussives and expectorants (dextromethorphan, diphenhydramine, chlophedianol, and guaifenesin) is absent for URI-associated pediatric cough. Alternatively, honey and topically applied vapor rubs may be effective antitussives.

Nonthermal Inactivation of Cronobacter sakazakii in Infant Formula Milk: A Review.

PubMed

Pina-Pérez, M C; Rodrigo, D; Martínez, A

2016-07-26

Up-to-date, nonthermal technologies and combinations of them, in accordance with the "hurdle technology" concept, are being applied by different research groups in response to calls by the International Food and Human Health Organizations (ESPGHAN, 2004; FAO/WHO, 2006, 2008) for alternatives to thermal control of Cronobacter sakazakii in reconstituted powdered infant formula milk. This review highlights (i) current knowledge on the application of nonthermal technologies to control C. sakazakii in infant formula milk and (ii) the importance of the application of nonthermal technologies for the control of C. sakazakii as part of the development of strategies in the context of improving food safety and quality of this product.

Dentistry and criminal law.

PubMed

Khoury, B S; Khoury, J N

2017-09-01

Criminal law in dentistry, as shaped and moulded by the prevailing views of society, defines what is or is not socially acceptable. It applies in both personal and professional contexts with the intended consequence of protecting the public from unacceptable conduct and potential imbalances of power. At its centre, a patient's consent plays a pivotal role in transforming unlawful conduct into lawful conduct. This literature review considers the current law and the trend of utilizing criminal law in addition to non-criminal law alternatives of reprimanding clinicians for failure to achieve consent in the course of dental practice. Dentists must appreciate this change and the prosecuting authority's increasing willingness to resort to criminal law. © 2017 Australian Dental Association.

Lean Management Systems in Radiology: Elements for Success.

PubMed

Schultz, Stacy R; Ruter, Royce L; Tibor, Laura C

2016-01-01

This article is a review of the literature on Lean and Lean Management Systems and how they have been implemented in healthcare organizations and particularly in radiology departments. The review focuses on the elements required for a successful implementation of Lean by applying the principles of a Lean Management System instead of a Lean tools-only approach. This review shares the successes and failures from healthcare organizations' efforts to improve the quality and safety of the services they provide. There are a limited number of healthcare organizations in the literature who have shared their experiences and additional research is necessary to determine whether a Lean Management System is a viable alternative to the current management structure in healthcare.

How to control bio-slime in condenser cooling system water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freymark, S.

1979-08-01

A number of oxidizing and non-oxidizing biocides are currently used for biocontrol. However, yesterday's solution to slime-fouling problems may not apply today in view of tightening effluent restrictions on chlorine. Thus, selection of biocontrol compounds can not be made indiscriminately. In selecting alternative biocontrol compounds, consideration should be given not only to costs but to effectiveness of the biocide in each particular application, taking into consideration cooling water quality, type of microbiological fouling and discharge restrictions. Thoughtful selection of the biocontrol compound(s), alone or in combination with surface-active agents, is essential for maintaining maximum microbiological control in condenser cooling watermore » systems.« less

Green and Bio-Based Solvents.

PubMed

Calvo-Flores, Francisco G; Monteagudo-Arrebola, María José; Dobado, José A; Isac-García, Joaquín

2018-04-24

Chemical reactions and many of the procedures of separation and purification employed in industry, research or chemistry teaching utilize solvents massively. In the last decades, with the birth of Green Chemistry, concerns about the employment of solvents and the effects on human health, as well as its environmental impacts and its dependence on non-renewable raw materials for manufacturing most of them, has drawn the attention of the scientific community. In this work, we review the concept of green solvent and the properties and characteristics to be considered green. Additionally, we discuss the different possible routes to prepare many solvents from biomass, as an alternative way to those methods currently applied in the petrochemical industry.

Immortalized Human Hepatic Cell Lines for In Vitro Testing and Research Purposes.

PubMed

Ramboer, Eva; Vanhaecke, Tamara; Rogiers, Vera; Vinken, Mathieu

2015-01-01

The ubiquitous shortage of primary human hepatocytes has urged the scientific community to search for alternative cell sources, such as immortalized hepatic cell lines. Over the years, several human hepatic cell lines have been produced, whether or not using a combination of viral oncogenes and human telomerase reverse transcriptase protein. Conditional approaches for hepatocyte immortalization have also been established and allow generation of growth-controlled cell lines. A variety of immortalized human hepatocytes have already proven useful as tools for liver-based in vitro testing and fundamental research purposes. The present chapter describes currently applied immortalization strategies and provides an overview of the actually available immortalized human hepatic cell lines and their in vitro applications.

Towards systems metabolic engineering of microorganisms for amino acid production.

PubMed

Park, Jin Hwan; Lee, Sang Yup

2008-10-01

Microorganisms capable of efficient production of amino acids have traditionally been developed by random mutation and selection method, which might cause unwanted physiological changes in cellular metabolism. Rational genome-wide metabolic engineering based on systems and synthetic biology tools, which is termed 'systems metabolic engineering', is rising as an alternative to overcome these problems. Recently, several amino acid producers have been successfully developed by systems metabolic engineering, where the metabolic engineering procedures were performed within a systems biology framework, and entire metabolic networks, including complex regulatory circuits, were engineered in an integrated manner. Here we review the current status of systems metabolic engineering successfully applied for developing amino acid producing strains and discuss future prospects.

Energy efficiency of high-rise buildings

NASA Astrophysics Data System (ADS)

Zhigulina, Anna Yu.; Ponomarenko, Alla M.

2018-03-01

The article is devoted to analysis of tendencies and advanced technologies in the field of energy supply and energy efficiency of tall buildings, to the history of the emergence of the concept of "efficiency" and its current interpretation. Also the article show the difference of evaluation criteria of the leading rating systems LEED and BREEAM. Authors reviewed the latest technologies applied in the construction of energy efficient buildings. Methodological approach to the design of tall buildings taking into account energy efficiency needs to include the primary energy saving; to seek the possibility of production and accumulation of alternative electric energy by converting energy from the sun and wind with the help of special technical devices; the application of regenerative technologies.

77 FR 15359 - Availability of Seats for the Stellwagen Bank National Marine Sanctuary Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-15

...: (1) At-Large Member; (2) Research Alternate; (1) Youth Member; and (1) Youth Alternate. Applicants... are applying; community and professional affiliations; philosophy regarding the protection and...

46 CFR 111.30-25 - Alternating-current ship's service switchboards.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-25 Section 111.30-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Switchboards § 111.30-25 Alternating-current ship's service... regulator unit acting on the exciter field, each switchboard must have: (1) A generator field rheostat; (2...

46 CFR 111.30-25 - Alternating-current ship's service switchboards.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-25 Section 111.30-25 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Switchboards § 111.30-25 Alternating-current ship's service... regulator unit acting on the exciter field, each switchboard must have: (1) A generator field rheostat; (2...

A FRAME response to the Draft Report on Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects--2010.

PubMed

Balls, Michael; Clothier, Richard

2010-10-01

This response on behalf of FRAME to the European Commission's consultation on the five chapters of the Draft Report on Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects--2010, is via a Comment in ATLA, rather than via the template supplied by the Commission. This is principally so that a number of general points about cosmetic ingredient testing can be made. It is concluded that the five draft chapters do not provide a credible basis for the Commission's forthcoming report to the European Parliament and the European Council on the five cosmetic ingredient safety issues for which the 7th Amendment to the Cosmetic Directive's ban on animal testing was postponed until 2013. This is mainly because there is insufficient focus in the draft chapters on the specific nature of cosmetic ingredients, their uses, their local effects and metabolism at their sites of application, and, in particular, on whether their possible absorption into the body would be likely to lead to their accumulation in target sites at levels approaching Thresholds of Toxicological Concern. Meanwhile, there continues to be uncertainty about how the provisions of the Cosmetics Directive should be applied, given the requirements of the REACH system and directives concerned with the safety of other chemicals and products. © 2010 FRAME.

3D Printed Graphene Based Energy Storage Devices

NASA Astrophysics Data System (ADS)

Foster, Christopher W.; Down, Michael P.; Zhang, Yan; Ji, Xiaobo; Rowley-Neale, Samuel J.; Smith, Graham C.; Kelly, Peter J.; Banks, Craig E.

2017-03-01

3D printing technology provides a unique platform for rapid prototyping of numerous applications due to its ability to produce low cost 3D printed platforms. Herein, a graphene-based polylactic acid filament (graphene/PLA) has been 3D printed to fabricate a range of 3D disc electrode (3DE) configurations using a conventional RepRap fused deposition moulding (FDM) 3D printer, which requires no further modification/ex-situ curing step. To provide proof-of-concept, these 3D printed electrode architectures are characterised both electrochemically and physicochemically and are advantageously applied as freestanding anodes within Li-ion batteries and as solid-state supercapacitors. These freestanding anodes neglect the requirement for a current collector, thus offering a simplistic and cheaper alternative to traditional Li-ion based setups. Additionally, the ability of these devices’ to electrochemically produce hydrogen via the hydrogen evolution reaction (HER) as an alternative to currently utilised platinum based electrodes (with in electrolysers) is also performed. The 3DE demonstrates an unexpectedly high catalytic activity towards the HER (-0.46 V vs. SCE) upon the 1000th cycle, such potential is the closest observed to the desired value of platinum at (-0.25 V vs. SCE). We subsequently suggest that 3D printing of graphene-based conductive filaments allows for the simple fabrication of energy storage devices with bespoke and conceptual designs to be realised.

Cytotoxicity assays with fish cells as an alternative to the acute lethality test with fish.

PubMed

Segner, Helmut

2004-10-01

In ecotoxicology, in vitro assays with fish cells are currently applied for mechanistic studies, bioanalytical purposes and toxicity screening. This paper discusses the potential of cytotoxicity assays with fish cells to reduce, refine or replace acute lethality tests using fish. Basal cytotoxicity data obtained with fish cell lines or fish primary cell cultures show a reasonable to good correlation with lethality data from acute toxicity tests, with the exception of compounds that exert a specific mode of toxic action. Basal cytotoxicity data from fish cell lines also correlate well with cytotoxicity data from mammalian cell lines. However, both the piscine and mammalian in vitro assays are clearly less sensitive than the fish test. Therefore, in vivo LC50 values (concentrations of the test compounds that are lethal to 50% of the fish in the experiment within 96 hours) currently cannot be predicted from in vitro values. This in vitro-in vivo difference in sensitivity appears to be true for both fish cell lines and mammalian cell lines. Given the good in vitro-in vivo correlation in toxicity ranking, together with the clear-cut difference in sensitivity, the role of cytotoxicity assays in a tiered alternative testing strategy could be in priority setting in relation to toxic hazard and in the toxicity classification of chemicals and environmental samples.

A quantitative risk assessment model to evaluate effective border control measures for rabies prevention

PubMed Central

Weng, Hsin-Yi; Wu, Pei-I; Yang, Ping-Cheng; Tsai, Yi-Lun; Chang, Chao-Chin

2009-01-01

Border control is the primary method to prevent rabies emergence. This study developed a quantitative risk model incorporating stochastic processes to evaluate whether border control measures could efficiently prevent rabies introduction through importation of cats and dogs using Taiwan as an example. Both legal importation and illegal smuggling were investigated. The impacts of reduced quarantine and/or waiting period on the risk of rabies introduction were also evaluated. The results showed that Taiwan’s current animal importation policy could effectively prevent rabies introduction through legal importation of cats and dogs. The median risk of a rabid animal to penetrate current border control measures and enter Taiwan was 5.33 × 10−8 (95th percentile: 3.20 × 10−7). However, illegal smuggling may pose Taiwan to the great risk of rabies emergence. Reduction of quarantine and/or waiting period would affect the risk differently, depending on the applied assumptions, such as increased vaccination coverage, enforced custom checking, and/or change in number of legal importations. Although the changes in the estimated risk under the assumed alternatives were not substantial except for completely abolishing quarantine, the consequences of rabies introduction may yet be considered to be significant in a rabies-free area. Therefore, a comprehensive benefit-cost analysis needs to be conducted before recommending these alternative measures. PMID:19822125

Translational-circular scanning for magneto-acoustic tomography with current injection.

PubMed

Wang, Shigang; Ma, Ren; Zhang, Shunqi; Yin, Tao; Liu, Zhipeng

2016-01-27

Magneto-acoustic tomography with current injection involves using electrical impedance imaging technology. To explore the potential applications in imaging biological tissue and enhance image quality, a new scan mode for the transducer is proposed that is based on translational and circular scanning to record acoustic signals from sources. An imaging algorithm to analyze these signals is developed in respect to this alternative scanning scheme. Numerical simulations and physical experiments were conducted to evaluate the effectiveness of this scheme. An experiment using a graphite sheet as a tissue-mimicking phantom medium was conducted to verify simulation results. A pulsed voltage signal was applied across the sample, and acoustic signals were recorded as the transducer performed stepped translational or circular scans. The imaging algorithm was used to obtain an acoustic-source image based on the signals. In simulations, the acoustic-source image is correlated with the conductivity at the sample boundaries of the sample, but image results change depending on distance and angular aspect of the transducer. In general, as angle and distance decreases, the image quality improves. Moreover, experimental data confirmed the correlation. The acoustic-source images resulting from the alternative scanning mode has yielded the outline of a phantom medium. This scan mode enables improvements to be made in the sensitivity of the detecting unit and a change to a transducer array that would improve the efficiency and accuracy of acoustic-source images.

3D Printed Graphene Based Energy Storage Devices

PubMed Central

Foster, Christopher W.; Down, Michael P.; Zhang, Yan; Ji, Xiaobo; Rowley-Neale, Samuel J.; Smith, Graham C.; Kelly, Peter J.; Banks, Craig E.

2017-01-01

3D printing technology provides a unique platform for rapid prototyping of numerous applications due to its ability to produce low cost 3D printed platforms. Herein, a graphene-based polylactic acid filament (graphene/PLA) has been 3D printed to fabricate a range of 3D disc electrode (3DE) configurations using a conventional RepRap fused deposition moulding (FDM) 3D printer, which requires no further modification/ex-situ curing step. To provide proof-of-concept, these 3D printed electrode architectures are characterised both electrochemically and physicochemically and are advantageously applied as freestanding anodes within Li-ion batteries and as solid-state supercapacitors. These freestanding anodes neglect the requirement for a current collector, thus offering a simplistic and cheaper alternative to traditional Li-ion based setups. Additionally, the ability of these devices’ to electrochemically produce hydrogen via the hydrogen evolution reaction (HER) as an alternative to currently utilised platinum based electrodes (with in electrolysers) is also performed. The 3DE demonstrates an unexpectedly high catalytic activity towards the HER (−0.46 V vs. SCE) upon the 1000th cycle, such potential is the closest observed to the desired value of platinum at (−0.25 V vs. SCE). We subsequently suggest that 3D printing of graphene-based conductive filaments allows for the simple fabrication of energy storage devices with bespoke and conceptual designs to be realised. PMID:28256602

Current devices of respiratory physiotherapy

PubMed Central

Hristara-Papadopoulou, A; Tsanakas, J; Diomou, G; Papadopoulou, O

2008-01-01

In recent years patients with respiratory diseases use various devices, which help the removal of mucus from the airways and the improvement of pulmonary function. The aim of the present study is to determine the effectiveness of the current devices of respiratory physiotherapy, as it comes from the review of literature. The current devices of physiotherapy for patients with respiratory diseases, are presented as an alternative therapy method or a supplemental therapy and they can motivate patients to apply therapy by themselves. These devices seem to increase patients' compliance to daily treatment, because they present many benefits, as independent application, full control of therapy and easy use. These devices are the Positive Expiratory Pressure, the High Frequency Chest Wall Oscillation, the Oral High Frequency Oscillation, the Intrapulmonary Percussive Ventilation, the Incentive Spirometry the Flutter and the Acapella and the Cornet. Current devices seem to be effective in terms of mucus expectoration and pulmonary function improvement, as it is shown by published studies. The choice of the suitable device for each patient is a challenge for the physiotherapist in order to achieve better compliance in daily treatment. More controlled studies are needed due to the fact that the number of published studies is limited. PMID:19158964

Charge Carrier Conduction Mechanism in PbS Quantum Dot Solar Cells: Electrochemical Impedance Spectroscopy Study.

PubMed

Wang, Haowei; Wang, Yishan; He, Bo; Li, Weile; Sulaman, Muhammad; Xu, Junfeng; Yang, Shengyi; Tang, Yi; Zou, Bingsuo

2016-07-20

With its properties of bandgap tunability, low cost, and substrate compatibility, colloidal quantum dots (CQDs) are becoming promising materials for optoelectronic applications. Additionally, solution-processed organic, inorganic, and hybrid ligand-exchange technologies have been widely used in PbS CQDs solar cells, and currently the maximum certified power conversion efficiency of 9.9% has been reported by passivation treatment of molecular iodine. Presently, there are still some challenges, and the basic physical mechanism of charge carriers in CQDs-based solar cells is not clear. Electrochemical impedance spectroscopy is a monitoring technology for current by changing the frequency of applied alternating current voltage, and it provides an insight into its electrical properties that cannot be measured by direct current testing facilities. In this work, we used EIS to analyze the recombination resistance, carrier lifetime, capacitance, and conductivity of two typical PbS CQD solar cells Au/PbS-TBAl/ZnO/ITO and Au/PbS-EDT/PbS-TBAl/ZnO/ITO, in this way, to better understand the charge carriers conduction mechanism behind in PbS CQD solar cells, and it provides a guide to design high-performance quantum-dots solar cells.

Conductance of Ion Channels - Theory vs. Experiment

NASA Technical Reports Server (NTRS)

Pohorille, Andrew; Wilson, Michael; Mijajlovic, Milan

2013-01-01

Transmembrane ion channels mediate a number of essential physiological processes in a cell ranging from regulating osmotic pressure to transmission of neural signals. Kinetics and selectivity of ion transport is of critical importance to a cell and, not surprisingly, it is a subject of numerous experimental and theoretical studies. In this presentation we will analyze in detail computer simulations of two simple channels from fungi - antiamoebin and trichotoxin. Each of these channels is made of an alpha-helical bundle of small, nongenomically synthesized peptides containing a number of rare amino acids and exhibits strong antimicrobial activity. We will focus on calculating ionic conductance defined as the ratio of ionic current through the channel to applied voltage. From molecular dynamics simulations, conductance can be calculated in at least two ways, each involving different approximations. Specifically, the current, given as the number of charges transferred through the channel per unit of time, can be obtained from the number of events in which ions cross the channel during the simulation. This method works well for large currents (high conductance values and/or applied voltages). If the number of crossing events is small, reliable estimates of current are difficult to achieve. Alternatively, conductance can be estimated assuming that ion transport can be well approximated as diffusion in the external potential given by the free energy profile. Then, the current can be calculated by solving the one-dimensional diffusion equation in this external potential and applied voltage (the generalized Nernst-Planck equation). To do so three ingredients are needed: the free energy profile, the position-dependent diffusion coefficient and the diffusive flux of ions into the channel. All these quantities can be obtained from molecular dynamics simulations. An important advantage of this method is that it can be used equally well to estimating large and small currents. In addition, once the free energy profile becomes available the full current-voltage dependence can be readily obtained. For both channels we carried out calculations using both approaches. We also tested the main assumptions underlying the diffusive model, such as uncorrelated nature of individual crossing events and Fickian diffusion. The accuracy and consistency of different methods will be discussed. Finally we will discuss how comparisons between calculated and measured ionic conductance and selectivity of transport can be used for determining structural models of the channels.

Implications of an Absolute Simultaneity Theory for Cosmology and Universe Acceleration

PubMed Central

Kipreos, Edward T.

2014-01-01

An alternate Lorentz transformation, Absolute Lorentz Transformation (ALT), has similar kinematics to special relativity yet maintains absolute simultaneity in the context of a preferred reference frame. In this study, it is shown that ALT is compatible with current experiments to test Lorentz invariance only if the proposed preferred reference frame is locally equivalent to the Earth-centered non-rotating inertial reference frame, with the inference that in an ALT framework, preferred reference frames are associated with centers of gravitational mass. Applying this theoretical framework to cosmological data produces a scenario of universal time contraction in the past. In this scenario, past time contraction would be associated with increased levels of blueshifted light emissions from cosmological objects when viewed from our current perspective. The observation that distant Type Ia supernovae are dimmer than predicted by linear Hubble expansion currently provides the most direct evidence for an accelerating universe. Adjusting for the effects of time contraction on a redshift–distance modulus diagram produces a linear distribution of supernovae over the full redshift spectrum that is consistent with a non-accelerating universe. PMID:25536116

Density-functional theory for internal magnetic fields

NASA Astrophysics Data System (ADS)

Tellgren, Erik I.

2018-01-01

A density-functional theory is developed based on the Maxwell-Schrödinger equation with an internal magnetic field in addition to the external electromagnetic potentials. The basic variables of this theory are the electron density and the total magnetic field, which can equivalently be represented as a physical current density. Hence, the theory can be regarded as a physical current density-functional theory and an alternative to the paramagnetic current density-functional theory due to Vignale and Rasolt. The energy functional has strong enough convexity properties to allow a formulation that generalizes Lieb's convex analysis formulation of standard density-functional theory. Several variational principles as well as a Hohenberg-Kohn-like mapping between potentials and ground-state densities follow from the underlying convex structure. Moreover, the energy functional can be regarded as the result of a standard approximation technique (Moreau-Yosida regularization) applied to the conventional Schrödinger ground-state energy, which imposes limits on the maximum curvature of the energy (with respect to the magnetic field) and enables construction of a (Fréchet) differentiable universal density functional.

Implications of an absolute simultaneity theory for cosmology and universe acceleration.

PubMed

Kipreos, Edward T

2014-01-01

An alternate Lorentz transformation, Absolute Lorentz Transformation (ALT), has similar kinematics to special relativity yet maintains absolute simultaneity in the context of a preferred reference frame. In this study, it is shown that ALT is compatible with current experiments to test Lorentz invariance only if the proposed preferred reference frame is locally equivalent to the Earth-centered non-rotating inertial reference frame, with the inference that in an ALT framework, preferred reference frames are associated with centers of gravitational mass. Applying this theoretical framework to cosmological data produces a scenario of universal time contraction in the past. In this scenario, past time contraction would be associated with increased levels of blueshifted light emissions from cosmological objects when viewed from our current perspective. The observation that distant Type Ia supernovae are dimmer than predicted by linear Hubble expansion currently provides the most direct evidence for an accelerating universe. Adjusting for the effects of time contraction on a redshift-distance modulus diagram produces a linear distribution of supernovae over the full redshift spectrum that is consistent with a non-accelerating universe.

Identification of linearised RMS-voltage dip patterns based on clustering in renewable plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

García-Sánchez, Tania; Gómez-Lázaro, Emilio; Muljadi, Edward

Generation units connected to the grid are currently required to meet low-voltage ride-through (LVRT) requirements. In most developed countries, these requirements also apply to renewable sources, mainly wind power plants and photovoltaic installations connected to the grid. This study proposes an alternative characterisation solution to classify and visualise a large number of collected events in light of current limits and requirements. The authors' approach is based on linearised root-mean-square-(RMS)-voltage trajectories, taking into account LRVT requirements, and a clustering process to identify the most likely pattern trajectories. The proposed solution gives extensive information on an event's severity by providing a simplemore » but complete visualisation of the linearised RMS-voltage patterns. In addition, these patterns are compared to current LVRT requirements to determine similarities or discrepancies. A large number of collected events can then be automatically classified and visualised for comparative purposes. Real disturbances collected from renewable sources in Spain are used to assess the proposed solution. Extensive results and discussions are also included in this study.« less

Critical and Alternative Directions in Applied Linguistics

ERIC Educational Resources Information Center

Pennycook, Alastair

2010-01-01

Critical directions in applied linguistics can be understood in various ways. The term "critical" as it has been used in "critical applied linguistics," "critical discourse analysis," "critical literacy" and so forth, is now embedded as part of applied linguistic work, adding an overt focus on questions of power and inequality to discourse…

Alternative Tobacco Product Use and Smoking Cessation: A National Study

PubMed Central

Popova, Lucy

2013-01-01

Objectives. We investigated the frequency of alternative tobacco product use (loose leaf, moist snuff, snus, dissolvables, electronic cigarettes [e-cigarettes]) among smokers and the association with quit attempts and intentions. Methods. A nationally representative probability-based cross-sectional survey of 1836 current or recently former adult smokers was completed in November 2011. Multivariate logistic regressions evaluated associations between alternative tobacco product use and smoking cessation behaviors. Results. Of the smokers, 38% had tried an alternative tobacco product, most frequently e-cigarettes. Alternative tobacco product use was associated with having made a quit attempt, and those intending to quit were significantly more likely to have tried and to currently use the products than were smokers with no intentions to quit. Use was not associated with successful quit attempts. Interest in future use of alternative tobacco products was low, except for e-cigarettes. Conclusions. Alternative tobacco products are attractive to smokers who want to quit smoking, but these data did not indicate that alternative tobacco products promote cessation. Unsubstantiated overt and implied claims that alternative tobacco products aid smoking cessation should be prohibited. PMID:23488521

Fabrication and actuation of electro-active polymer actuator based on PSMI-incorporated PVDF

NASA Astrophysics Data System (ADS)

Lu, Jun; Kim, Sang-Gyun; Lee, Sunwoo; Oh, Il-Kwon

2008-08-01

In this study, an ionic networking membrane (INM) of poly(styrene-alt-maleimide) (PSMI)-incorporated poly(vinylidene fluoride) (PVDF) was applied to fabricate electro-active polymer. Based on the same original membrane of PSMI-incorporated PVDF, various samples of INM actuator were prepared for different reduction times with the electroless-plating technique. The as-prepared INM actuators were tested in terms of surface resistance, platinum morphology, resonance frequency, tip displacement, current and blocked force, and their performances were compared to those of the widely used traditional Nafion actuator. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that much smaller and more uniform platinum particles were formed on the surfaces of the INM actuators as well as within their polymer matrix. Although excellent harmonic responses were observed for the newly developed INM actuators, they were found to be sensitive to the applied reduction times during the fabrication. The mechanical displacement of the INM actuator fabricated after the optimum reduction times was much larger than that of its Nafion counterpart of comparable thickness under the stimulus of constant and alternating current voltage. The PSMI-incorporated PVDF actuator can become a promising smart material to be used in the fields of biomimetic robots, biomedical devices, sensors and actuator, haptic interfaces, energy harvesting and so on.

78 FR 49723 - Humboldt-Toiyabe National Forests; Ely Ranger District; Ely Westside Rangeland Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-15

... Month (AUM) production for the Humboldt National Forest while improving the gap between existing and...: 1. Current Management Alternative: Continue current grazing management. 2. No Grazing Alternative... documents. (Authority: 40 CFR 1501.7 and 1508.22; Forest Service Handbook 1909.15, Section 21) Dated: August...

Alternatives to Tenure. AAHE-ERIC/Higher Education Research Currents. March 1979.

ERIC Educational Resources Information Center

Linney, Thomas J.

An overview of current literature about alternatives and variations to existing concepts of tenure of faculty is presented. Tenure continues the appointment of faculty until retirement unless there is dismissal for adequate cause or unavoidable termination because of financial exigency or change of institutional program. Academic freedom is…

Method and apparatus for detecting cyber attacks on an alternating current power grid

DOE Office of Scientific and Technical Information (OSTI.GOV)

McEachern, Alexander; Hofmann, Ronald

A method and apparatus for detecting cyber attacks on remotely-operable elements of an alternating current distribution grid. Two state estimates of the distribution grid are prepared, one of which uses micro-synchrophasors. A difference between the two state estimates indicates a possible cyber attack.

Solar cell system having alternating current output

NASA Technical Reports Server (NTRS)

Evans, J. C., Jr. (Inventor)

1980-01-01

A monolithic multijunction solar cell was modified by fabricating an integrated circuit inverter on the back of the cell to produce a device capable of generating an alternating current output. In another embodiment, integrated curcuit power conditioning electronics was incorporated in a module containing a solar cell power supply.

30 CFR 47.43 - Label alternatives.

Code of Federal Regulations, 2010 CFR

2010-07-01

... COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.43 Label alternatives. The operator may... container to which it applies, (b) Communicates the same information as required on the label, and (c) Is...

Alternatives for Jet Engine Control

NASA Technical Reports Server (NTRS)

Leake, R. J.; Sain, M. K.

1976-01-01

Approaches are developed as alternatives to current design methods which rely heavily on linear quadratic and Riccati equation methods. The main alternatives are discussed in two broad categories, local multivariable frequency domain methods and global nonlinear optimal methods.

Evaluation of alternative snowplowable markers and snowplowing procedures.

DOT National Transportation Integrated Search

2013-06-01

The objectives of this study were to investigate viable alternatives to the currently approved snowplowable raised pavement marker and alternative methods and equipment used to snowplow roadways. The study included evaluating any potential durable an...

Why Police Kill Black Males with Impunity: Applying Public Health Critical Race Praxis (PHCRP) to Address the Determinants of Policing Behaviors and "Justifiable" Homicides in the USA.

PubMed

Gilbert, Keon L; Ray, Rashawn

2016-04-01

Widespread awareness of the recent deaths of several black males at the hands of police has revealed an unaddressed public health challenge-determining the root causes of excessive use of force by police applied to black males that may result in "justifiable homicides." The criminalization of black males has a long history in the USA, which has resulted in an increase in policing behaviors by legal authorities and created inequitable life chances for black males. Currently, the discipline of public health has not applied an intersectional approach that investigates the intersection of race and gender to understanding police behaviors that lead to "justifiable homicides" for black males. This article applies the core tenets and processes of Public Health Critical Race Praxis (PHCRP) to develop a framework that can improve research and interventions to address the disparities observed in recent trend analyses of "justifiable homicides." Accordingly, we use PHCRP to offer an alternative framework on the social, legal, and health implications of violence-related incidents. We aim to move the literature in this area forward to help scholars, policymakers, and activists build the capacity of communities to address the excessive use of force by police to reduce mortality rates from "justifiable homicides."

Applying Simulated In Vivo Motions to Measure Human Knee and ACL Kinetics

PubMed Central

Herfat, Safa T.; Boguszewski, Daniel V.; Shearn, Jason T.

2013-01-01

Patients frequently experience anterior cruciate ligament (ACL) injuries but current ACL reconstruction strategies do not restore the native biomechanics of the knee, which can contribute to the early onset of osteoarthritis in the long term. To design more effective treatments, investigators must first understand normal in vivo knee function for multiple activities of daily living (ADLs). While the 3D kinematics of the human knee have been measured for various ADLs, the 3D kinetics cannot be directly measured in vivo. Alternatively, the 3D kinetics of the knee and its structures can be measured in an animal model by simulating and applying subject-specific in vivo joint motions to a joint using robotics. However, a suitable biomechanical surrogate should first be established. This study was designed to apply a simulated human in vivo motion to human knees to measure the kinetics of the human knee and ACL. In pursuit of establishing a viable biomechanical surrogate, a simulated in vivo ovine motion was also applied to human knees to compare the loads produced by the human and ovine motions. The motions from the two species produced similar kinetics in the human knee and ACL. The only significant difference was the intact knee compression force produced by the two input motions. PMID:22227973

75 FR 32963 - Notice of Availability of the Draft Resource Management Plan and Draft Environmental Impact...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-10

.... Alternative B: Same as Alternative A. Alternative C: ACEC would be rescinded. Closed to wind and solar energy... mineral material sales. Closed to wind and solar energy. Closed to motorized travel. Visual Resource... and Hilltop. Closed to wind and solar energy. Visual Resource Management Class I would apply to a...

40 CFR 80.213 - What alternative sulfur standards and requirements apply to transmix processors and transmix...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 16 2011-07-01 2011-07-01 false What alternative sulfur standards and... ADDITIVES Gasoline Sulfur Gasoline Sulfur Standards § 80.213 What alternative sulfur standards and... TGP meets the applicable sulfur standards under § 80.210 or § 80.220, prior to the TGP leaving the...

40 CFR 80.213 - What alternative sulfur standards and requirements apply to transmix processors and transmix...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What alternative sulfur standards and... ADDITIVES Gasoline Sulfur Gasoline Sulfur Standards § 80.213 What alternative sulfur standards and... TGP meets the applicable sulfur standards under § 80.210 or § 80.220, prior to the TGP leaving the...

40 CFR 80.213 - What alternative sulfur standards and requirements apply to transmix processors and transmix...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 17 2014-07-01 2014-07-01 false What alternative sulfur standards and... ADDITIVES Gasoline Sulfur Gasoline Sulfur Standards § 80.213 What alternative sulfur standards and... TGP meets the applicable sulfur standards under § 80.210 or § 80.220, prior to the TGP leaving the...

40 CFR 80.213 - What alternative sulfur standards and requirements apply to transmix processors and transmix...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false What alternative sulfur standards and... ADDITIVES Gasoline Sulfur Gasoline Sulfur Standards § 80.213 What alternative sulfur standards and... TGP meets the applicable sulfur standards under § 80.210 or § 80.220, prior to the TGP leaving the...

Simulation of fault performance of a diesel engine driven brushless alternator through PSPICE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayanan, S.S.Y.; Ananthakrishnan, P.; Hangari, V.U.

1995-12-31

Analysis of the fault performance of a brushless alternator with damper windings in the main alternator has been handled ab initio as a total modeling and simulation problem through proper application of Park`s equivalent circuit approach individually to the main exciter alternator units of the brushless alternator and the same has been implemented through PSPICE. The accuracy of the parameters used in the modeling and results obtained through PSPICE implementation are then evaluated for a specific 125 kVA brushless alternator in two stages as followed: first, by comparison of the predicted fault performance obtained from simulation of the 125 kVAmore » main alternator alone treated as a conventional alternator with the results obtained through the use of closed form analytical expressions available in the literature for fault currents and torques in such conventional alternators. Secondly, by comparison of some of the simulation results with those obtained experimentally on the brushless alternator itself. To enable proper calculation of derating factors to be used in the design of such brushless alternators, simulation results then include harmonic analysis of the steady state fault currents and torques. Throughout these studies, the brushless alternator is treated to be on no load at the instant of occurrence of fault.« less

Alternative solutions for public and private catastrophe funding in Austria

NASA Astrophysics Data System (ADS)

Gruber, M.

2008-07-01

The impacts of natural hazards as well as their frequency of occurrence during the last decades have increased decisively. Therefore, the public as well as the private sector are expected to react to this development by providing sufficient funds, in particular for the improvement of protection measures and an enhanced funding of damage compensation for affected private individuals, corporate and public entities. From the public stance, the establishment of an appropriate regulatory environment seems to be indispensable. Structural and legal changes should, on the one hand, renew and improve the current distribution system of public catastrophe funds as well as the profitable investment of these financial resources, and on the other hand, facilitate the application of alternative mechanisms provided by the capital and insurance markets. In particular, capital markets have developed alternative risk transfer and financing mechanisms, such as captive insurance companies, risk pooling, contingent capital solutions, multi-trigger products and insurance securitisation for hard insurance market phases. These instruments have already been applied to catastrophic (re-)insurance in other countries (mainly the US and off-shore domiciles), and may contribute positively to the insurability of extreme weather events in Austria by enhancing financial capacities. Not only private individuals and corporate entities may use alternative mechanisms in order to retain, thus, to finance certain risks, but also public institutions. This contribution aims at analysing potential solutions for an improved risk management of natural hazards in the private and the public sector by considering alternative mechanisms of the capital and insurance markets. Also the establishment of public-private-partnerships, which may contribute to a more efficient cat funding system in Austria, is considered.

Economic analysis of recycling contaminated concrete

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephen, A.; Ayers, K.W.; Boren, J.K.

1997-02-01

Decontamination and Decommissioning activities in the DOE complex generate large volumes of radioactively contaminated and uncontaminated concrete. Currently, this concrete is usually decontaminated, the contaminated waste is disposed of in a LLW facility and the decontaminated concrete is placed in C&D landfills. A number of alternatives to this practice are available including recycling of the concrete. Cost estimates for six alternatives were developed using a spreadsheet model. The results of this analysis show that recycling alternatives are at least as economical as current practice.

Basing assessment and treatment of problem behavior on behavioral momentum theory: Analyses of behavioral persistence.

PubMed

Schieltz, Kelly M; Wacker, David P; Ringdahl, Joel E; Berg, Wendy K

2017-08-01

The connection, or bridge, between applied and basic behavior analysis has been long-established (Hake, 1982; Mace & Critchfield, 2010). In this article, we describe how clinical decisions can be based more directly on behavioral processes and how basing clinical procedures on behavioral processes can lead to improved clinical outcomes. As a case in point, we describe how applied behavior analyses of maintenance, and specifically the long-term maintenance of treatment effects related to problem behavior, can be adjusted and potentially enhanced by basing treatment on Behavioral Momentum Theory. We provide a brief review of the literature including descriptions of two translational studies that proposed changes in how differential reinforcement of alternative behavior treatments are conducted based on Behavioral Momentum Theory. We then describe current clinical examples of how these translations are continuing to impact the definitions, designs, analyses, and treatment procedures used in our clinical practice. Copyright © 2017 Elsevier B.V. All rights reserved.

Risk-benefit analysis and public policy: a bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, E.M.; Van Horn, A.J.

1976-11-01

Risk-benefit analysis has been implicitly practiced whenever decision-makers are confronted with decisions involving risks to life, health, or to the environment. Various methodologies have been developed to evaluate relevant criteria and to aid in assessing the impacts of alternative projects. Among these have been cost-benefit analysis, which has been widely used for project evaluation. However, in many cases it has been difficult to assign dollar costs to those criteria involving risks and benefits which are not now assigned explicit monetary values in our economic system. Hence, risk-benefit analysis has evolved to become more than merely an extension of cost-benefit analysis,more » and many methods have been applied to examine the trade-offs between risks and benefits. In addition, new scientific and statistical techniques have been developed for assessing current and future risks. The 950 references included in this bibliography are meant to suggest the breadth of those methodologies which have been applied to decisions involving risk.« less

Self-assembly of metal nanowires induced by alternating current electric fields

NASA Astrophysics Data System (ADS)

García-Sánchez, Pablo; Arcenegui, Juan J.; Morgan, Hywel; Ramos, Antonio

2015-01-01

We describe the reversible assembly of an aqueous suspension of metal nanowires into two different 2-dimensional stable configurations. The assembly is induced by an AC electric field of magnitude around 10 kV/m. It is known that single metal nanowires orientate parallel to the electric field for all values of applied frequency, according to two different mechanisms depending on the frequency. These different mechanisms also govern the mutual interaction between nanowires, which leads to directed-assembly into distinctive structures, the shape of which depends on the frequency of the applied field. We show that for frequencies higher than the typical frequency for charging the electrical double layer at the metal-electrolyte interface, dipole-dipole interaction leads to the formation of chains of nanowires. For lower frequencies, the nanowires form wavy bands perpendicular to the electric field direction. This behavior appears to be driven by the electroosmotic flow induced on the metal surface of the nanowires. Remarkably, no similar structures have been reported in previous studies of nanowires.

Comparison of bioactive glass coated and hydroxyapatite coated titanium dental implants in the human jaw bone.

PubMed

Mistry, S; Kundu, D; Datta, S; Basu, D

2011-03-01

Current trends in clinical dental implant therapy include modification of titanium surfaces for the purpose of improving osseointegration by different additive (bioactive coatings) and subtractive processes (acid etching, grit-blasting). The aim of this study was to evaluate and compare the behaviour of hydroxyapatite and the newly developed bioactive glass coated implants (62 implants) in osseous tissue following implantation in 31 patients. Bioactive glass and hydroxyapatite was suitably coated on titanium alloy. Hydroxyapatite coating was applied on the implant surface by air microplasma spray technique and bioactive glass coating was applied by vitreous enamelling technique. The outcome was assessed up to 12 months after prosthetic loading using different clinical and radiological parameters. Hydroxyapatite and bioactive glass coating materials were non-toxic and biocompatible. Overall results showed that bioactive glass coated implants were as equally successful as hydroxyapatite in achieving osseointegration and supporting final restorations. The newly developed bioactive glass is a good alternative coating material for dental implants. © 2011 Australian Dental Association.

Low-Thermal-Conductivity Pyrochlore Oxide Materials Developed for Advanced Thermal Barrier Coatings

NASA Technical Reports Server (NTRS)

Bansal, Narottam P.; Zhu, Dong-Ming

2005-01-01

When turbine engines operate at higher temperatures, they consume less fuel, have higher efficiencies, and have lower emissions. The upper-use temperatures of the base materials (superalloys, silicon-based ceramics, etc.) used for the hot-section components of turbine engines are limited by the physical, mechanical, and corrosion characteristics of these materials. Thermal barrier coatings (TBCs) are applied as thin layers on the surfaces of these materials to further increase the operating temperatures. The current state-of-the-art TBC material in commercial use is partially yttria-stabilized zirconia (YSZ), which is applied on engine components by plasma spraying or by electron-beam physical vapor deposition. At temperatures higher than 1000 C, YSZ layers are prone to sintering, which increases thermal conductivity and makes them less effective. The sintered and densified coatings can also reduce thermal stress and strain tolerance, which can reduce the coating s durability significantly. Alternate TBC materials with lower thermal conductivity and better sintering resistance are needed to further increase the operating temperature of turbine engines.

Early Warning Signals of Ecological Transitions: Methods for Spatial Patterns

PubMed Central

Brock, William A.; Carpenter, Stephen R.; Ellison, Aaron M.; Livina, Valerie N.; Seekell, David A.; Scheffer, Marten; van Nes, Egbert H.; Dakos, Vasilis

2014-01-01

A number of ecosystems can exhibit abrupt shifts between alternative stable states. Because of their important ecological and economic consequences, recent research has focused on devising early warning signals for anticipating such abrupt ecological transitions. In particular, theoretical studies show that changes in spatial characteristics of the system could provide early warnings of approaching transitions. However, the empirical validation of these indicators lag behind their theoretical developments. Here, we summarize a range of currently available spatial early warning signals, suggest potential null models to interpret their trends, and apply them to three simulated spatial data sets of systems undergoing an abrupt transition. In addition to providing a step-by-step methodology for applying these signals to spatial data sets, we propose a statistical toolbox that may be used to help detect approaching transitions in a wide range of spatial data. We hope that our methodology together with the computer codes will stimulate the application and testing of spatial early warning signals on real spatial data. PMID:24658137

Positive psychology and war: an oxymoron.

PubMed

Phipps, Sean

2011-10-01

The author was deeply disturbed by the January 2011 issue of the American Psychologist, which engendered a series of emotions in the author: first dismay, then anger, and finally a sense of shame about the current state of the profession. This was ostensibly an exposition of "positive psychology" principles and how they are to be applied in a colossal experiment designed to support our military in their fight against the ideology of jihadist Islam. The author found it hard to see what was positive in the presentation. Not one of the authors in this special issue discussed applying positive psychology principles to the reduction of conflict between nations, to the prevention of war, or to the promotion of peace. How about a positive psychology that questions the wisdom of leaders who tell us that the use of force is unavoidable, and seeks instead to help them find alternative, peaceful solutions? A true positive psychology should be primarily addressed to eradicating the disease of war, not to supporting those who fight it.

Testing Alternative Definitions of Chronic Homelessness.

PubMed

Byrne, Thomas; Culhane, Dennis P

2015-09-01

This study examined the potential impact of a proposed change to the official federal definition of chronic homelessness. Using administrative data from the emergency shelters in a large U.S. city, this study estimated the number of persons identified as chronically homeless under the current definition of chronic homelessness, a proposed new federal definition, and two alternative definitions and examined shelter utilization for each group. Fewer than half as many people were considered chronically homeless under the proposed new federal definition compared with the current definition. Persons considered chronically homeless by the proposed new definition and, to a lesser extent, by the two alternative definitions, made heavier use of shelter compared with persons who met the current definition. A proposed new and two alternative definitions of chronic homelessness are better suited than the existing federal definition for identifying persons with the most protracted experiences of homelessness.

“Nobody tosses a dwarf!” The relation between the empirical and normative reexamined

PubMed Central

Leget, C.; Borry, P.; De Vries, R.

2009-01-01

This article discusses the relation between empirical and normative approaches in bioethics. The issue of dwarf tossing, while admittedly unusual, is chosen as point of departure because it challenges the reader to look upon several central bioethical themes – including human dignity, autonomy, and the protection of vulnerable people – with fresh eyes. After an overview of current approaches to the integration of empirical and normative ethics, we consider five ways that the empirical and normative can be brought together to speak to the problem of dwarf tossing: prescriptive applied ethics, theorist ethics, critical applied ethics, particularist ethics and integrated empirical ethics. We defend a position of critical applied ethics that allows for a two-way relation between empirical and normative theories. The approach we endorse acknowledges that a social practice can and should be judged by both the gathering of empirical data and by the normative ethics. Critical applied ethics uses a five stage process that includes: (a) determination of the problem, (b) description of the problem, (c) empirical study of effects and alternatives, (d) normative weighing and (e) evaluation of the effects of a decision. In each stage, we explore the perspective from both the empirical (sociological) and the normative ethical poles that, in our view, should operate as two independent focuses of the ellipse that is called bioethics. We conclude by applying our five stage critical applied ethics to the example of dwarf tossing. PMID:19338523

'Nobody tosses a dwarf!' The relation between the empirical and the normative reexamined.

PubMed

Leget, Carlo; Borry, Pascal; de Vries, Raymond

2009-05-01

This article discusses the relation between empirical and normative approaches in bioethics. The issue of dwarf tossing, while admittedly unusual, is chosen as a point of departure because it challenges the reader to look with fresh eyes upon several central bioethical themes, including human dignity, autonomy, and the protection of vulnerable people. After an overview of current approaches to the integration of empirical and normative ethics, we consider five ways that the empirical and normative can be brought together to speak to the problem of dwarf tossing: prescriptive applied ethics, theoretical ethics, critical applied ethics, particularist ethics and integrated empirical ethics. We defend a position of critical applied ethics that allows for a two-way relation between empirical and normative theories. Against efforts fully to integrate the normative and the empirical into one synthesis, we propose that the two should stand in tension and relation to one another. The approach we endorse acknowledges that a social practice can and should be judged both by the gathering of empirical data and by normative ethics. Critical applied ethics uses a five stage process that includes: (a) determination of the problem, (b) description of the problem, (c) empirical study of effects and alternatives, (d) normative weighing and (e) evaluation of the effects of a decision. In each stage, we explore the perspective from both the empirical (sociological) and the normative ethical point of view. We conclude by applying our five-stage critical applied ethics to the example of dwarf tossing.

A boundary element alternating method for two-dimensional mixed-mode fracture problems

NASA Technical Reports Server (NTRS)

Raju, I. S.; Krishnamurthy, T.

1992-01-01

A boundary element alternating method, denoted herein as BEAM, is presented for two dimensional fracture problems. This is an iterative method which alternates between two solutions. An analytical solution for arbitrary polynomial normal and tangential pressure distributions applied to the crack faces of an embedded crack in an infinite plate is used as the fundamental solution in the alternating method. A boundary element method for an uncracked finite plate is the second solution. For problems of edge cracks a technique of utilizing finite elements with BEAM is presented to overcome the inherent singularity in boundary element stress calculation near the boundaries. Several computational aspects that make the algorithm efficient are presented. Finally, the BEAM is applied to a variety of two dimensional crack problems with different configurations and loadings to assess the validity of the method. The method gives accurate stress intensity factors with minimal computing effort.

In Vivo Demonstration of Addressable Microstimulators Powered by Rectification of Epidermically Applied Currents for Miniaturized Neuroprostheses

PubMed Central

2015-01-01

Electrical stimulation is used in order to restore nerve mediated functions in patients with neurological disorders, but its applicability is constrained by the invasiveness of the systems required to perform it. As an alternative to implantable systems consisting of central stimulation units wired to the stimulation electrodes, networks of wireless microstimulators have been devised for fine movement restoration. Miniaturization of these microstimulators is currently hampered by the available methods for powering them. Previously, we have proposed and demonstrated a heterodox electrical stimulation method based on electronic rectification of high frequency current bursts. These bursts can be delivered through textile electrodes on the skin. This approach has the potential to result in an unprecedented level of miniaturization as no bulky parts such as coils or batteries are included in the implant. We envision microstimulators designs based on application-specific integrated circuits (ASICs) that will be flexible, thread-like (diameters < 0.5 mm) and not only with controlled stimulation capabilities but also with sensing capabilities for artificial proprioception. We in vivo demonstrate that neuroprostheses composed of addressable microstimulators based on this electrical stimulation method are feasible and can perform controlled charge-balanced electrical stimulation of muscles. We developed miniature external circuit prototypes connected to two bipolar probes that were percutaneously implanted in agonist and antagonist muscles of the hindlimb of an anesthetized rabbit. The electronic implant architecture was able to decode commands that were amplitude modulated on the high frequency (1 MHz) auxiliary current bursts. The devices were capable of independently stimulating the target tissues, accomplishing controlled dorsiflexion and plantarflexion joint movements. In addition, we numerically show that the high frequency current bursts comply with safety standards both in terms of tissue heating and unwanted electro-stimulation. We demonstrate that addressable microstimulators powered by rectification of epidermically applied currents are feasible. PMID:26147771

In Vivo Demonstration of Addressable Microstimulators Powered by Rectification of Epidermically Applied Currents for Miniaturized Neuroprostheses.

PubMed

Becerra-Fajardo, Laura; Ivorra, Antoni

2015-01-01

Electrical stimulation is used in order to restore nerve mediated functions in patients with neurological disorders, but its applicability is constrained by the invasiveness of the systems required to perform it. As an alternative to implantable systems consisting of central stimulation units wired to the stimulation electrodes, networks of wireless microstimulators have been devised for fine movement restoration. Miniaturization of these microstimulators is currently hampered by the available methods for powering them. Previously, we have proposed and demonstrated a heterodox electrical stimulation method based on electronic rectification of high frequency current bursts. These bursts can be delivered through textile electrodes on the skin. This approach has the potential to result in an unprecedented level of miniaturization as no bulky parts such as coils or batteries are included in the implant. We envision microstimulators designs based on application-specific integrated circuits (ASICs) that will be flexible, thread-like (diameters < 0.5 mm) and not only with controlled stimulation capabilities but also with sensing capabilities for artificial proprioception. We in vivo demonstrate that neuroprostheses composed of addressable microstimulators based on this electrical stimulation method are feasible and can perform controlled charge-balanced electrical stimulation of muscles. We developed miniature external circuit prototypes connected to two bipolar probes that were percutaneously implanted in agonist and antagonist muscles of the hindlimb of an anesthetized rabbit. The electronic implant architecture was able to decode commands that were amplitude modulated on the high frequency (1 MHz) auxiliary current bursts. The devices were capable of independently stimulating the target tissues, accomplishing controlled dorsiflexion and plantarflexion joint movements. In addition, we numerically show that the high frequency current bursts comply with safety standards both in terms of tissue heating and unwanted electro-stimulation. We demonstrate that addressable microstimulators powered by rectification of epidermically applied currents are feasible.

Alternative tobacco use among college students: who is at highest risk?

PubMed

Enofe, Nosayaba; Berg, Carla J; Nehl, Eric J

2014-03-01

To examines smoking status, substance use, sociodemographics, and psychosocial characteristics in relation to alternative tobacco use among college students. Current tobacco use (cigarettes, cigar-like products, hookah, chew, snus) and correlates (sociodemographics, sensation-seeking, attitudes toward tobacco and smokers, social factors) were assessed among students aged 18-25 at 6 Southeastern US colleges using an online survey. Those who were younger, male, black, cigarette and marijuana users, and demonstrating at-risk psychosocial factors were at increased risk of alternative tobacco product use (p < .001). Among current smokers, never daily nondaily smokers were 3 times as likely as former daily non-daily smokers and daily smokers to use alternative tobacco products (p < .001). Important risk factors for alternative tobacco use included important sociodemographic and psychosocial characteristics.

Decontamination of soils containing PAHs by electroremediation: a review.

PubMed

Pazos, M; Rosales, E; Alcántara, T; Gómez, J; Sanromán, M A

2010-05-15

During the last years, the anthropogenic sources have contributed to organic compound penetration into the environment. One large group of persistent and toxic contaminants is the hydrophobic organic contaminants. Among them, polycyclic aromatic hydrocarbons (PAHs) have been recognized as a representative group of these pollutants with low solubility. In this paper, it is showed the electroremediation of soil contaminated with PAHs as an alternative, to organic compound removal. This technique, mainly used for heavy metal extraction, applies the electric current to promote the movement of contaminants. Nowadays the application of this technique alone or combined with other techniques as for example Fenton or bioremediation is taking fine results to PAHs removal. Although the PAHs soil decontamination by means of the electric field is in an initial stage, many researchers have demonstrated the treatment effectiveness. This paper describes the foremost principles to carry out the electroremediation of soils contaminated with PAHs, just like the different alternatives to improve the electroremediation of PAHs and also the new methodologies of PAHs removal by using hybrid technologies. Copyright (c) 2009 Elsevier B.V. All rights reserved.

Passive control of discrete-frequency tones generated by coupled detuned cascades

NASA Astrophysics Data System (ADS)

Sawyer, S.; Fleeter, S.

2003-07-01

Discrete-frequency tones generated by rotor-stator interactions are of particular concern in the design of fans and compressors. Classical theory considers an isolated flat-plate cascade of identical uniformly spaced airfoils. The current analysis extends this tuned isolated cascade theory to consider coupled aerodynamically detuned cascades where aerodynamic detuning is accomplished by changing the chord of alternate rotor blades and stator vanes. In a coupled cascade analysis, the configuration of the rotor influences the downstream acoustic response of the stator, and the stator configuration influences the upstream acoustic response of the rotor. This coupled detuned cascade unsteady aerodynamic model is first applied to a baseline tuned stage. This baseline stage is then aerodynamically detuned by replacing alternate rotor blades and stator vanes with decreased chord airfoils. The nominal aerodynamically detuned stage configuration is then optimized, with the stage acoustic response decreased 13 dB upstream and 1 dB downstream at the design operating condition. A reduction in the acoustic response of the optimized aerodynamically detuned stage is then demonstrated over a range of operating conditions.

The successful of finite element to invent particle cleaning system by air jet in hard disk drive

NASA Astrophysics Data System (ADS)

Jai-Ngam, Nualpun; Tangchaichit, Kaitfa

2018-02-01

Hard Disk Drive manufacturing has faced very challenging with the increasing demand of high capacity drives for Cloud-based storage. Particle adhesion has also become increasingly important in HDD to gain more reliability of storage capacity. The ability to clean on surfaces is more complicated in removing such particles without damaging the surface. This research is aim to improve the particle cleaning in HSA by using finite element to develop the air flow model then invent the prototype of air cleaning system to remove particle from surface. Surface cleaning by air pressure can be applied as alternative for the removal of solid particulate contaminants that is adhering on a solid surface. These technical and economic challenges have driven the process development from traditional way that chemical solvent cleaning. The focus of this study is to develop alternative way from scrub, ultrasonic, mega sonic on surface cleaning principles to serve as a foundation for the development of new processes to meet current state-of-the-art process requirements and minimize the waste from chemical cleaning for environment safety.

Alternative Land-Use Scenarios for Bioenergy Production in the U.S. and Brazil

NASA Astrophysics Data System (ADS)

Campbell, J. E.; Spak, S.; Tsao, C. C.; Mena, M.; Chen, Y.

2015-12-01

Agriculture is historically a dominant form of global environmental degradation, and the potential for increased future degradation may be enhanced by growing demand for biofuels. Here, we apply high-resolution cropland inventories and agronomic models to characterize land-use impacts and mitigation scenarios for bioenergy production in the U.S. and Brazil. In the U.S., our gridded historical cropland maps show potential for production in the U.S. on 68 Mha of abandoned croplands in the U.S. which is as much as 70% larger than previous estimates due to a reduction in aggregation effects. In Brazil, a critical land-use impact is associated with non-GHG air pollutants from the management and expansion of sugarcane feedstocks. Our bottom-up estimate for these Brazilian land-use emissions is seven times larger than estimated from remote-sensing data due to the improved spatial resolution of our approach. While current land-use policies in Brazil and the U.S. seek to reduce life-cycle biofuel emissions, these policies may not support the mitigation alternatives identified here.

A Framework for Ethical Decision Making in the Rehabilitation of Patients with Anosognosia.

PubMed

Egbert, Anna Rita

2017-01-01

Currently, the number of patients diagnosed with impaired self-awareness of their own deficits after brain injury-anosognosia-is increasing. One reason is a growing understanding of this multifaceted phenomenon. Another is the development and accessibility of alternative measurements that allow more detailed diagnoses. Anosognosia can adversely affect successful rehabilitation, as often patients lack confidence in the need for treatment. Planning such treatment can become a complex process full of ethical dilemmas. To date, there is no systematic way to deal with different aspects of anosognosia rehabilitation planning. This is the first article to present a framework for ethical decision making in establishing rehabilitation plans that are focused on increasing patients' self-awareness of their own deficits after brain injury. It concentrates especially on addressing the ethical dilemmas that may arise, and describes stepwise procedures that can be applied to distinct theoretical approaches, as well as diagnostic and rehabilitation methods. To show the flexibility of the use of this framework, alternative approaches are discussed. Copyright 2016 The Journal of Clinical Ethics. All rights reserved.

An alternative approach for computing seismic response with accidental eccentricity

NASA Astrophysics Data System (ADS)

Fan, Xuanhua; Yin, Jiacong; Sun, Shuli; Chen, Pu

2014-09-01

Accidental eccentricity is a non-standard assumption for seismic design of tall buildings. Taking it into consideration requires reanalysis of seismic resistance, which requires either time consuming computation of natural vibration of eccentric structures or finding a static displacement solution by applying an approximated equivalent torsional moment for each eccentric case. This study proposes an alternative modal response spectrum analysis (MRSA) approach to calculate seismic responses with accidental eccentricity. The proposed approach, called the Rayleigh Ritz Projection-MRSA (RRP-MRSA), is developed based on MRSA and two strategies: (a) a RRP method to obtain a fast calculation of approximate modes of eccentric structures; and (b) an approach to assemble mass matrices of eccentric structures. The efficiency of RRP-MRSA is tested via engineering examples and compared with the standard MRSA (ST-MRSA) and one approximate method, i.e., the equivalent torsional moment hybrid MRSA (ETM-MRSA). Numerical results show that RRP-MRSA not only achieves almost the same precision as ST-MRSA, and is much better than ETM-MRSA, but is also more economical. Thus, RRP-MRSA can be in place of current accidental eccentricity computations in seismic design.

A simple and cost-effective method, as an appropriate alternative for visible spectrophotometry: development of a dopamine biosensor.

PubMed

Abbaspour, Abdolkarim; Khajehzadeh, Abdolreza; Ghaffarinejad, Ali

2009-08-01

In this study, a new, simple, fast and inexpensive method as an alternative to visible spectrophotometry is developed. In this method the cells containing the sample solution were scanned with a scanner, then the color of each cell was analyzed with software written in visual basic (VB 6) media to red, green and blue values. The cells were built by creating holes in the Plexiglas sheet. The dimensions of identical cells were examined by Cr (III) solution with known concentrations. The validity of this new method was studied by determination of dopamine (DA) without using any other reagent. The parameters which affect the system were optimized. The comparison between the current and traditional UV-Vis spectrophotometry methods was studied and the results revealed similar trends in both methods. The developed method was successfully applied to the determination of dopamine in serum and urine without using any pretreatment. Finally comparing the results obtained in the developed method showed that microwave irradiation of the solution can decrease the experimental time, increase sensitivity and improve the limit of detection.

Laparoscopic surgical treatment of umbilical hernia and small eventrations with prosthetic mesh using omentum overlay.

PubMed

Bratu, D; Sabău, A; Dumitra, A; Sabău, D; Miheţiu, A; Beli, L; Hulpuş, R

2014-01-01

Umbilical hernias and abdominal incisional hernias represent current pathologies which require numerous surgical alternative ways of treatment in prosthetic or non prosthetic,open or minimally invasive surgery. The method proposed by us is a less expensive option with no additional risks compared to other similar procedures as surgical technique. We conducted a retrospective study between 01.01.2008 - 01.06.2013 in which we considered a number of 23 patients with umbilical hernia and eventration, patients who received laparoscopic intraperitoneal polyester mesh covered with omentum, procedure applied at the IInd Surgery Clinic, Clinical County Emergency Hospital Sibiu. Out of 23 patients with postoperative umbilical hernia and eventration cases in which we used this surgical technique,16 were umbilical hernias and 7 post incisional hernias. The average time of surgery was 1 hour and 40 minutes, recording 4 postoperative complications remitted under conservative treatment, with a mean hospitalization of 4.1 days. Proepiploic laparoscopic treatment using omentum is a reliable alternative to a more expensive and difficult procedure involving Dual Mesh. Celsius.

Alternative Delivery Systems: A Potential Partnership for Education and Public Broadcasting.

ERIC Educational Resources Information Center

Baltzer, Jan A.

If educators and public broadcasters are to realize their potential for providing high quality educational and cultural material to the public, they must be aware of current and upcoming technologies and work in concert to achieve their goals. Several alternative delivery systems are currently available to help educators and broadcasters expand…

Overhaul of ESEA Could Drop Option of Alternate Exams

ERIC Educational Resources Information Center

Shah, Nirvi

2011-01-01

Renewal proposals for the Elementary and Secondary Education Act (ESEA), the current version of which is the No Child Left Behind (NCLB) Act, are still being discussed by congressional lawmakers and staff. Capitol Hill aides and U.S. Department of Education officials have suggested that a current federal regulation governing alternate testing for…

The Use of Augmentative and Alternative Communication in Cyprus: Findings from a Preliminary Survey

ERIC Educational Resources Information Center

Pampoulou, Eliada; Theodorou, Eleni; Petinou, Kakia

2018-01-01

Whilst augmentative and alternative communication has been used for over sixty years across many countries, in Cyprus it remains underdeveloped. The current study seeks to investigate the current AAC practices in Cyprus. Data were collected through electronically distributed questionnaires to all registered speech and language therapists (n =…

10 CFR 50.63 - Loss of all alternating current power.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., Limitations, and Conditions of Licenses and Construction Permits § 50.63 Loss of all alternating current power... manufacturing license under part 52 of this chapter must be able to withstand for a specified duration and recover from a station blackout as defined in § 50.2. The specified station blackout duration shall be...

Alternatives to neonicotinoid insecticides for pest control: case studies in agriculture and forestry.

PubMed

Furlan, Lorenzo; Kreutzweiser, David

2015-01-01

Neonicotinoid insecticides are widely used for control of insect pests around the world and are especially pervasive in agricultural pest management. There is a growing body of evidence indicating that the broad-scale and prophylactic uses of neonicotinoids pose serious risks of harm to beneficial organisms and their ecological function. This provides the impetus for exploring alternatives to neonicotinoid insecticides for controlling insect pests. We draw from examples of alternative pest control options in Italian maize production and Canadian forestry to illustrate the principles of applying alternatives to neonicotinoids under an integrated pest management (IPM) strategy. An IPM approach considers all relevant and available information to make informed management decisions, providing pest control options based on actual need. We explore the benefits and challenges of several options for management of three insect pests in maize crops and an invasive insect pest in forests, including diversifying crop rotations, altering the timing of planting, tillage and irrigation, using less sensitive crops in infested areas, applying biological control agents, and turning to alternative reduced risk insecticides. Continued research into alternatives is warranted, but equally pressing is the need for information transfer and training for farmers and pest managers and the need for policies and regulations to encourage the adoption of IPM strategies and their alternative pest control options.

Hydrodynamics of spatially inhomogeneous real membranes

NASA Astrophysics Data System (ADS)

Kirii, V. A.; Shelistov, V. S.; Demekhin, E. A.

2017-07-01

Electrokinetic processes in the vicinity of inhomogeneous ion-selective surfaces (electrodes, membranes, microchannels, and nanochannels) consisting of alternating conducting and nonconducting regions in the presence of a normal-to-surface electric current are numerically studied. An increase in the electric current density is observed in the case of some particular alternation of conducting and nonconducting regions of the surface. The current-voltage characteristics of homogeneous and inhomogeneous electric membranes are found to be in qualitative agreement. Various physical phenomena leading to the emergence of a supercritical current in homogeneous and inhomogeneous membranes are detected.

Alternatives to animal testing: information resources via the Internet and World Wide Web.

PubMed

Hakkinen, P J Bert; Green, Dianne K

2002-04-25

Many countries, including the United States, Canada, European Union member states, and others, require that a comprehensive search for possible alternatives be completed before beginning some or all research involving animals. Completing comprehensive alternatives searches and keeping current with information associated with alternatives to animal testing is a challenge that will be made easier as people throughout the world gain access to the Internet and World Wide Web. Numerous Internet and World Wide Web resources are available to provide guidance and other information on in vitro and other alternatives to animal testing. A comprehensive Web site is Alternatives to Animal Testing on the Web (Altweb), which serves as an online clearinghouse for resources, information, and news about alternatives to animal testing. Examples of other important Web sites include the joint one for the (US) Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and the Norwegian Reference Centre for Laboratory Animal Science and Alternatives (The NORINA database). Internet mailing lists and online access to bulletin boards, discussion areas, newsletters, and journals are other ways to access and share information to stay current with alternatives to animal testing.

Traditional and Alternate Routes to Teacher Certification: Issues, Assumptions, and Misconceptions. Issue Paper 95-2.

ERIC Educational Resources Information Center

Stoddart, Trish; Floden, Robert E.

States have created "alternate" routes to teacher certification. Comparison of alternate and college-based programs reveals clear trends in recruitment but a mixed picture regarding development of expertise. Alternate certification represents a radical departure from the current norm of teacher preparation. Several factors have led to…

Superconductors Enable Lower Cost MRI Systems

NASA Technical Reports Server (NTRS)

2013-01-01

The future looks bright, light, and green, especially where aircraft are concerned. The division of NASA s Fundamental Aeronautics Program called the Subsonic Fixed Wing Project is aiming to reach new heights by 2025-2035, improving the efficiency and environmental impact of air travel by developing new capabilities for cleaner, quieter, and more fuel efficient aircraft. One of the many ways NASA plans to reach its aviation goals is by combining new aircraft configurations with an advanced turboelectric distributed propulsion (TeDP) system. Jeff Trudell, an engineer at Glenn Research Center, says, "The TeDP system consists of gas turbines generating electricity to power a large number of distributed motor-driven fans embedded into the airframe." The combined effect increases the effective bypass ratio and reduces drag to meet future goals. "While room temperature components may help reduce emissions and noise in a TeDP system, cryogenic superconducting electric motors and generators are essential to reduce fuel burn," says Trudell. Superconductors provide significantly higher current densities and smaller and lighter designs than room temperature equivalents. Superconductors are also able to conduct direct current without resistance (loss of energy) below a critical temperature and applied field. Unfortunately, alternating current (AC) losses represent the major part of the heat load and depend on the frequency of the current and applied field. A refrigeration system is necessary to remove the losses and its weight increases with decreasing temperature. In 2001, a material called magnesium diboride (MgB2) was discovered to be superconducting. The challenge, however, has been learning to manufacture MgB2 inexpensively and in long lengths to wind into large coils while meeting the application requirements.

Size and structure evolution of kaolin-Al(OH)3 flocs in the electroflocculation process: a study using static light scattering.

PubMed

Harif, T; Adin, A

2011-11-15

Electroflocculation (EF) is gaining recognition as an alternative process to conventional coagulation/flocculation. The electrical current applied in EF that generates the active coagulant species creates a unique chemical/physical environment in which competing redox reactions occur, primarily water electrolysis. This causes a transient rise in pH, due to cathodic formation of hydroxyl ions, which, in turn, causes a continuous shift in coagulation/flocculation mechanisms throughout the process. This highly impacts the formation of a sweep floc regime that relies on precipitation of metal hydroxide and its growth into floc. The size and structural evolution of kaolin-Al(OH)(3) flocs was examined using static light scattering techniques, in aim of elucidating kinetic aspects of the process. An EF cell was operated in batch mode and comprised of two concentric electrodes - a stainless steel cathode (inner electrode) and an aluminum anode (outer electrode). The cell was run at constant current between 0.042A and 0.22A, and analyses performed at pre-determined time intervals. The results demonstrate that EF is able to generate a range of flocs, exhibiting different growth rates and structural characteristics, depending on the conditions of operation. Growth patterns were sigmoidal and a linear correlation between growth rate and current applied was observed. The dependency of growth rate on current can be related to initial pH and aluminum dosing, with a stronger dependency apparent for initial optimal sweep floc regime. All flocs exhibited a fragile nature and undergo compaction and structural fluctuations during growth. This is the first time size and structural evolution of flocs formed in the EF process is reported. Copyright © 2011 Elsevier Ltd. All rights reserved.

Software compensation of eddy current fields in multislice high order dynamic shimming.

PubMed

Sengupta, Saikat; Avison, Malcolm J; Gore, John C; Brian Welch, E

2011-06-01

Dynamic B(0) shimming (DS) can produce better field homogeneity than static global shimming by dynamically updating slicewise shim values in a multislice acquisition. The performance of DS however is limited by eddy current fields produced by the switching of 2nd and 3rd order unshielded shims. In this work, we present a novel method of eddy field compensation (EFC) applied to higher order shim induced eddy current fields in multislice DS. This method does not require shim shielding, extra hardware for eddy current compensation or subject specific prescanning. The interactions between shim harmonics are modeled assuming steady state of the medium and long time constant, cross and self term eddy fields in a DS experiment and 'correction factors' characterizing the entire set of shim interactions are derived. The correction factors for a given time between shim switches are shown to be invariable with object scanned, shim switching pattern and actual shim values, allowing for their generalized prospective use. Phantom and human head, 2nd and 3rd order DS experiments performed without any hardware eddy current compensation using the technique show large reductions in field gradients and offsets leading to significant improvements in image quality. This method holds promise as an alternative to expensive hardware based eddy current compensation required in 2nd and 3rd order DS. Copyright © 2011 Elsevier Inc. All rights reserved.