Counselling--Alternative Approaches. Information Bank Working Paper No. 2476.

ERIC Educational Resources Information Center

Brookes, Jeannie

This document looks at various types of counseling approaches and includes sections on Rogerian counseling, Gestalt therapy, and rational emotive therapy. The section on Rogerian counseling includes a discussion of the principles of counseling from Rogers'"Client Centered Therapy." Gestalt therapy is explained in more detail and a…

Ethical Approaches to Compliance

ERIC Educational Resources Information Center

Buzo, Carina

2017-01-01

This article explores the role that higher education has in ethical compliance to Title IX and the Clery Act. The discussion includes a curious look at common practices as potential future approaches to consent and sexual assault education. Articles and research are included to ground understanding in the current context, while examples from a…

Deferred Maintenance Strategies You Must Try.

ERIC Educational Resources Information Center

Sturgeon, Julie

2000-01-01

Discusses how some college administrators have found "over-the-counter" cures for deferred maintenance problems resulting from budgeting shortfalls. Catch-up approaches discussed include those involving planning, prioritizing, partnering, and gift giving. (GR)

Conscientization: A New Direction for Ex-Inmate Education.

ERIC Educational Resources Information Center

Burstow, Bonnie

1989-01-01

The author discusses the applicability of and the need for Freirian pedagogy in the rehabilitation of former inmates. She discusses her applications of this approach at My Brother's Place, a halfway house for chronic offenders. A discussion of special learning issues is included. (CH)

History of psychosurgery: a psychiatrist's perspective.

PubMed

Lapidus, Kyle A B; Kopell, Brian H; Ben-Haim, Sharona; Rezai, Ali R; Goodman, Wayne K

2013-01-01

Interest in using neuromodulation to treat psychiatric disorders is rapidly increasing. The development of novel tools and techniques, such as deep brain stimulation (DBS), increases precision and minimizes risk. This article reviews the history of psychosurgical interventions and recent developments of DBS to provide a framework for understanding current options and future goals. We begin by discussing early approaches to psychosurgery, focusing on the widespread use of lobotomy and the subsequent backlash from the public and professionals in the field. Next, we discuss the development of stereotaxis. This technique allows for more targeted, precise interventions that produce discrete subcortical lesions. We focus on four stereotactic procedures that were developed using this technique: cingulotomy, capsulotomy, subcaudate tractotomy, and limbic leucotomy. We subsequently review contemporary theory and approaches with relevance to psychosurgery. We discuss the systems and neurocircuitry that are thought to be involved in psychiatric illness and provide targets for intervention. This discussion includes presentation of basal ganglia thalamocortical pathophysiology including cortico-striato-thalamo-cortical loops. We focus the discussion on two psychiatric disorders that have been targets of neurosurgical interventions: obsessive-compulsive disorder and mood disorders such as major depressive disorder. Evidence from studies of DBS in psychiatric disorders, including efficacy and tolerability, is reviewed. Finally, we look to the future, exploring the possibilities for these approaches to increase understanding, transform societal views of mental illness, and improve treatment. Copyright © 2013 Elsevier Inc. All rights reserved.

Improving organ donation rates by modifying the family approach process.

PubMed

Ebadat, Aileen; Brown, Carlos V R; Ali, Sadia; Guitierrez, Tim; Elliot, Eric; Dworaczyk, Sarah; Kadric, Carie; Coopwood, Ben

2014-06-01

The purpose of this study was to identify steps during family approach for organ donation that may be modified to improve consent rates of potential organ donors. Retrospective study of our local organ procurement organization (OPO) database of potential organ donors. Modifiable variables involved in the family approach of potential organ donors were collected and included race and sex of OPO representative, individual initiating approach discussion with family (RN or MD vs. OPO), length of donation discussion, use of a translator, and time of day of approach. Of 1137 potential organ donors, 661 (58%) consented and 476 (42%) declined. Consent rates were higher with matched race of donor and OPO representative (66% vs. 52%, p < 0.001), family approach by female OPO representative (67% vs. 56%, p = 0.002), if approach was initiated by OPO representative (69% vs. 49%, p < 0.001), and if consent rate was dependent on time of day the approach occurred: 6:00 am to noon (56%), noon to 6:00 pm (67%), 6:00 pm to midnight (68%), and midnight to 6:00 am (45%), p = 0.04. Family approach that led to consent lasted longer than those declining (67 vs. 43 minutes, p < 0.001). Independent predictors of consent to donation included female OPO representative (odds ratio [OR], 1.7; p = 0.006), approach discussion initiated by OPO representative (OR, 1.9; p = 0.001), and longer approach discussions (OR, 1.02; p < 0.001). The independent predictor of declined donation was the use of a translator (OR, 0.39; p = 0.01). Variables such as race and sex of OPO representative and time of day should be considered before approaching a family for organ donation. Avoiding translators during the approach process may improve donation rates. Education for health care providers should reinforce the importance of allowing OPO representatives to initiate the family approach for organ donation. Epidemiologic study, level IV. Therapeutic study, level IV.

Alternatives to Peer Review: Novel Approaches for Research Evaluation

PubMed Central

Birukou, Aliaksandr; Wakeling, Joseph Rushton; Bartolini, Claudio; Casati, Fabio; Marchese, Maurizio; Mirylenka, Katsiaryna; Osman, Nardine; Ragone, Azzurra; Sierra, Carles; Wassef, Aalam

2011-01-01

In this paper we review several novel approaches for research evaluation. We start with a brief overview of the peer review, its controversies, and metrics for assessing efficiency and overall quality of the peer review. We then discuss five approaches, including reputation-based ones, that come out of the research carried out by the LiquidPub project and research groups collaborated with LiquidPub. Those approaches are alternative or complementary to traditional peer review. We discuss pros and cons of the proposed approaches and conclude with a vision for the future of the research evaluation, arguing that no single system can suit all stakeholders in various communities. PMID:22174702

Treatment of dyslipidemia in HIV-infected patients.

PubMed

Sekhar, Rajagopal V; Balasubramanyam, Ashok

2010-08-01

Patients infected with HIV are at high risk for dyslipidemia, insulin resistance and cardiovascular disease. Therapies to reverse these risks are complex, sometimes controversial, and not uniformly effective. Pathophysiology of the lipid abnormalities in HIV is discussed, including the causes of alterations in triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and insulin resistance. We discuss the therapy of dyslipidemia in HIV using a combination of available clinical evidence and expert opinion based on extensive clinical experience, with discussions of lifestyle intervention and diet, conventional pharmacotherapy with lipid-lowering medications including statins, fibrates, niacin and thiazolidinediones for dyslipidemia, and newer therapeutic approaches including omega fatty acids, acipimox, growth hormone and leptin. A detailed understanding of the pathophysiology and rational or evidence-based approach to therapy of lipid abnormalities in patients infected with HIV. Treatment of dyslipidemia in patients with HIV is challenging and complicated by the risk of drug interactions. Appropriate therapy requires a sound understanding of pathophysiology and the principles of pharmacological and nonpharmacological therapeutic interventions. An evidence-based approach that combines lifestyle changes and drugs that are both safe and effective, singly and in combination, is described.

Staying Alive: Problems of Survival.

ERIC Educational Resources Information Center

Stalheim, Bill

1990-01-01

Presented is an approach to the teaching of biological diversity using the theme of survival. Teaching methods for this approach and the advantages of its use are discussed. A suggested course outline is included. (CW)

Environmental Study Plan for the Trinity River Basin, Texas

DTIC Science & Technology

1972-01-01

with the requirements of NEPA, as specified In Sec. 102. These requirements Include the utilization of "a systematic, interdisciplinary approach which...and making updated completion projections is therefore included (Appendix F). B. Basic approach of the proposed study. The proposed study is divided...different from the customary approach utilized by many research specialists. Some of these differences are discussed below. I. The study is not intended

Policy Options for Education Reform: A Policy Analysis Paper. Discussion Draft.

ERIC Educational Resources Information Center

Hansen, Kenneth H.

This document examines approaches to educational reform currently under consideration in the Pacific Northwest and discusses policy issues involved with these reform efforts. The introduction discusses broad-scale policy issues, including the setting of priorities amid the diversity of reforms, the clarifying of beliefs and selection of changes…

New Approaches to the Teaching of the Classics.

ERIC Educational Resources Information Center

Masciantonio, Rudolph, Ed.; Weislogel, Stephen, Ed.

This four-part report of the 1971-72 Classical Association of the Atlantic States Working Committee deals with the rationale for new approaches and curriculums for schools and colleges. Implications of the new approaches in teacher education are also teated. The major section treating new model curriculums and approaches includes discussion of:…

Hemostatic strategies for traumatic and surgical bleeding

PubMed Central

Behrens, Adam M.; Sikorski, Michael J.; Kofinas, Peter

2017-01-01

Wide interest in new hemostatic approaches has stemmed from unmet needs in the hospital and on the battlefield. Many current commercial hemostatic agents fail to fulfill the design requirements of safety, efficacy, cost, and storage. Academic focus has led to the improvement of existing strategies as well as new developments. This review will identify and discuss the three major classes of hemostatic approaches: biologically derived materials, synthetically derived materials, and intravenously administered hemostatic agents. The general class is first discussed, then specific approaches discussed in detail, including the hemostatic mechanisms and the advancement of the method. As hemostatic strategies evolve and synthetic-biologic interactions are more fully understood, current clinical methodologies will be replaced. PMID:24307256

A Unified Approach to the Study of Chemical Reactions in Freshman Chemistry.

ERIC Educational Resources Information Center

Cassen, T.; DuBois, Thomas D.

1982-01-01

Provides rationale and objectives for presenting chemical reactions in a unified, logical six-stage approach rather than a piecemeal approach. Stages discussed include: introduction, stable electronic configurations and stable oxidation states, reactions between two free elements, ion transfer/proton transfer reactions, double displacement…

A survey of computational methods and error rate estimation procedures for peptide and protein identification in shotgun proteomics

PubMed Central

Nesvizhskii, Alexey I.

2010-01-01

This manuscript provides a comprehensive review of the peptide and protein identification process using tandem mass spectrometry (MS/MS) data generated in shotgun proteomic experiments. The commonly used methods for assigning peptide sequences to MS/MS spectra are critically discussed and compared, from basic strategies to advanced multi-stage approaches. A particular attention is paid to the problem of false-positive identifications. Existing statistical approaches for assessing the significance of peptide to spectrum matches are surveyed, ranging from single-spectrum approaches such as expectation values to global error rate estimation procedures such as false discovery rates and posterior probabilities. The importance of using auxiliary discriminant information (mass accuracy, peptide separation coordinates, digestion properties, and etc.) is discussed, and advanced computational approaches for joint modeling of multiple sources of information are presented. This review also includes a detailed analysis of the issues affecting the interpretation of data at the protein level, including the amplification of error rates when going from peptide to protein level, and the ambiguities in inferring the identifies of sample proteins in the presence of shared peptides. Commonly used methods for computing protein-level confidence scores are discussed in detail. The review concludes with a discussion of several outstanding computational issues. PMID:20816881

Adaptive windowing and windowless approaches to estimate dynamic functional brain connectivity

NASA Astrophysics Data System (ADS)

Yaesoubi, Maziar; Calhoun, Vince D.

2017-08-01

In this work, we discuss estimation of dynamic dependence of a multi-variate signal. Commonly used approaches are often based on a locality assumption (e.g. sliding-window) which can miss spontaneous changes due to blurring with local but unrelated changes. We discuss recent approaches to overcome this limitation including 1) a wavelet-space approach, essentially adapting the window to the underlying frequency content and 2) a sparse signal-representation which removes any locality assumption. The latter is especially useful when there is no prior knowledge of the validity of such assumption as in brain-analysis. Results on several large resting-fMRI data sets highlight the potential of these approaches.

Academic Literacies as Cornerstones in Course Design: A Partnership to Develop Programming for Faculty and Teaching Assistants

ERIC Educational Resources Information Center

Bury, Sophie; Sheese, Ron

2016-01-01

We discuss an educational development approach to embedding academic literacies instruction within disciplinary curricula. This developmental, embedded approach contrasts with the generic, extra-curricular, study-skills approach adopted in many universities. Learning Commons partners at York University, including librarians, writing instructors,…

Robosphere: Self Sustaining Robotic Ecologies as Precursors to Human Planetary Exploration

NASA Technical Reports Server (NTRS)

Colombano, Silvano P.

2003-01-01

The present sequential mission oriented approach to robotic planetary exploration, could be changed to an infrastructure building approach where a robotic presence is permanent, self sustaining and growing with each mission. We call this self-sustaining robotic ecology approach robosphere and discuss the technological issues that need to be addressed before this concept can be realized. One of the major advantages of this approach is that a robosphere would include much of the infrastructure required by human explorers and would thus lower the preparation and risk threshold inherent in the transition from robotic to human exploration. In this context we discuss some implications for space architecture.

Chemical Mixture Risk Assessment Additivity-Based Approaches

EPA Science Inventory

Powerpoint presentation includes additivity-based chemical mixture risk assessment methods. Basic concepts, theory and example calculations are included. Several slides discuss the use of "common adverse outcomes" in analyzing phthalate mixtures.

The Right Approach in Practice: A Discussion of the Applicability of EFL Writing Practices in a Saudi Context

ERIC Educational Resources Information Center

Oraif, Iman M.

2016-01-01

The aim of this paper is to describe the different approaches applied to teaching writing in the L2 context and the way these different methods have been established so far. The perspectives include a product approach, genre approach and process approach. Each has its own merits and objectives for application. Regarding the study context, it may…

A rehabilitation model as key to comprehensive care in the era of HIV as a chronic disease in South Africa.

PubMed

Chetty, Verusia; Hanass-Hancock, Jill

2016-01-01

In the era of widespread access to antiretroviral therapy, people living with HIV survive; however, this comes with new experiences of comorbidities and HIV-related disability posing new challenges to rehabilitation professionals and an already fragile health system in Southern Africa. Public health approaches to HIV need to include not only prevention, treatment and support but also rehabilitation. While some well-resourced countries have developed rehabilitation approaches for HIV, resource-poor settings of Southern Africa lack a model of care that includes rehabilitation approaches providing accessible and comprehensive care for people living with HIV. In this study, a learning in action approach was used to conceptualize a comprehensive model of care that addresses HIV-related disability and a feasible rehabilitation framework for resource-poor settings. The study used qualitative methods in the form of a focus group discussion with thirty participants including people living with HIV, the multidisciplinary healthcare team and community outreach partners at a semi-rural health facility in South Africa. The discussion focused on barriers and enablers of access to rehabilitation. Participants identified barriers at various levels, including transport, physical access, financial constraints and poor multi-stakeholder team interaction. The results of the group discussions informed the design of an inclusive model of HIV care. This model was further informed by established integrated rehabilitation models. Participants emphasized that objectives need to respond to policy, improve access to patient-centered care and maintain a multidisciplinary team approach. They proposed that guiding principles should include efficient communication, collaboration of all stakeholders and leadership in teams to enable staff to implement the model. Training of professional staff and lay personnel within task-shifting approaches was seen as an essential enabler to implementation. The health facility as well as outreach services such as intermediate clinics, home-based care, outreach and community-based rehabilitation was identified as important structures for potential rehabilitation interventions.

Minimal Data and Site Specific Approaches

EPA Science Inventory

As part of a workshop, Tools for Assessing Stream Dissolved Minerals, approaches and EPA tools are described for site specific development of water quality criteria based on observations from Arkansas streams using minimal data. Discussion topics will include site-specific appro...

Behavior Therapy of Impotence

ERIC Educational Resources Information Center

Dengrove, Edward

1971-01-01

Behavior therapy approaches to the treatment of male sexual impotence, specifically premature ejaculation and erective impotence, are discussed. Included in the behavioral therapies are systematic desensitization, active graded therapy, assertive techniques, sexual responses, operant approaches and others. Often marriage counseling is also…

Avoiding your greatest fear--malpractice.

PubMed

Coy, Kenneth; Stratton, Russell

2002-01-01

This article discusses ten clinically based behavioral approaches to minimizing the risk of a malpractice claim. Suggestions are stated in both a positive and negative way and ranked from least significant to most significant. Recommendations include the need to develop effective listening skills; learning to communicate with patients verbally and in writing; keeping patient expectations realistic; being thorough when examining and diagnosing; and knowing one's limitations. Also included is the need to inform patients concerning adverse events; keeping written records of what was said and done; discussing alternatives, risks, complications, and fees in advance; and developing a relationship with patients based on mutual respect and trust. Case examples are presented for each approach.

Logic. Geometry Module for Use in a Mathematics Laboratory Setting.

ERIC Educational Resources Information Center

Brotherton, Sheila; And Others

Within this single module there are two approaches to this brief survey of logic. Since most geometry textbooks fail to give an adequate discussion of logic, a "textbook" treatment of the subject has been included. This is found as explanations interspersed in the exercises and these can be used as a textbook approach. However, also included is an…

Teaching "Islam and Human Rights" in the Classroom

ERIC Educational Resources Information Center

Muedini, Fait A.

2012-01-01

This article discusses my approach to teaching a course on Islam and human rights. I begin by examining the attention Islam has received in the media and classroom. Then, I discuss how I structure lectures on Islam and human rights, the various readings associated with the lectures, as well as common themes discussed in class that include but are…

The Value of Information: Approaches in Economics, Accounting, and Management Science.

ERIC Educational Resources Information Center

Repo, Aatto J.

1989-01-01

This review and analysis of research on the economics of information performed by economists, accounting researchers, and management scientists focuses on their approaches to describing and measuring the value of information. The discussion includes comparisons of research approaches based on cost effectiveness and on the value of information. (77…

Incorporating organisational safety culture within ergonomics practice.

PubMed

Bentley, Tim; Tappin, David

2010-10-01

This paper conceptualises organisational safety culture and considers its relevance to ergonomics practice. Issues discussed in the paper include the modest contribution that ergonomists and ergonomics as a discipline have made to this burgeoning field of study and the significance of safety culture to a systems approach. The relevance of safety culture to ergonomics work with regard to the analysis, design, implementation and evaluation process, and implications for participatory ergonomics approaches, are also discussed. A potential user-friendly, qualitative approach to assessing safety culture as part of ergonomics work is presented, based on a recently published conceptual framework that recognises the dynamic and multi-dimensional nature of safety culture. The paper concludes by considering the use of such an approach, where an understanding of different aspects of safety culture within an organisation is seen as important to the success of ergonomics projects. STATEMENT OF RELEVANCE: The relevance of safety culture to ergonomics practice is a key focus of this paper, including its relationship with the systems approach, participatory ergonomics and the ergonomics analysis, design, implementation and evaluation process. An approach to assessing safety culture as part of ergonomics work is presented.

Review of Instructional Approaches in Ethics Education.

PubMed

Mulhearn, Tyler J; Steele, Logan M; Watts, Logan L; Medeiros, Kelsey E; Mumford, Michael D; Connelly, Shane

2017-06-01

Increased investment in ethics education has prompted a variety of instructional objectives and frameworks. Yet, no systematic procedure to classify these varying instructional approaches has been attempted. In the present study, a quantitative clustering procedure was conducted to derive a typology of instruction in ethics education. In total, 330 ethics training programs were included in the cluster analysis. The training programs were appraised with respect to four instructional categories including instructional content, processes, delivery methods, and activities. Eight instructional approaches were identified through this clustering procedure, and these instructional approaches showed different levels of effectiveness. Instructional effectiveness was assessed based on one of nine commonly used ethics criteria. With respect to specific training types, Professional Decision Processes Training (d = 0.50) and Field-Specific Compliance Training (d = 0.46) appear to be viable approaches to ethics training based on Cohen's d effect size estimates. By contrast, two commonly used approaches, General Discussion Training (d = 0.31) and Norm Adherence Training (d = 0.37), were found to be considerably less effective. The implications for instruction in ethics training are discussed.

Theme Courses for Community Colleges.

ERIC Educational Resources Information Center

Conway, Diana

1986-01-01

Discusses organization of community college Spanish courses around themes, such as geography, life sciences, arts, holidays, in conjunction with techniques such as the Natural Approach and Total Physical Response. The discussion includes examples of class activities, suggestions for materials, and notes on accommodating different levels. (SED)

A Multimodal Approach in Dealing with Chronic Epstein-Barr Viral Syndrome.

ERIC Educational Resources Information Center

Weikel, William J.

1989-01-01

Discusses Epstein-Barr Viral Syndrome, a puzzling and controversial disease with a variety of symptoms that frequently include depression and emotional debilitation. Offers diagnostic signs and suggests a possible treatment strategy based on the multimodal approach. (Author/ABL)

Approaches to Aggregation and Decision Making-A Health Economics Approach: An ISPOR Special Task Force Report [5].

PubMed

Phelps, Charles E; Lakdawalla, Darius N; Basu, Anirban; Drummond, Michael F; Towse, Adrian; Danzon, Patricia M

2018-02-01

The fifth section of our Special Task Force report identifies and discusses two aggregation issues: 1) aggregation of cost and benefit information across individuals to a population level for benefit plan decision making and 2) combining multiple elements of value into a single value metric for individuals. First, we argue that additional elements could be included in measures of value, but such elements have not generally been included in measures of quality-adjusted life-years. For example, we describe a recently developed extended cost-effectiveness analysis (ECEA) that provides a good example of how to use a broader concept of utility. ECEA adds two features-measures of financial risk protection and income distributional consequences. We then discuss a further option for expanding this approach-augmented CEA, which can introduce many value measures. Neither of these approaches, however, provide a comprehensive measure of value. To resolve this issue, we review a technique called multicriteria decision analysis that can provide a comprehensive measure of value. We then discuss budget-setting and prioritization using multicriteria decision analysis, issues not yet fully resolved. Next, we discuss deliberative processes, which represent another important approach for population- or plan-level decisions used by many health technology assessment bodies. These use quantitative information on CEA and other elements, but the group decisions are reached by a deliberative voting process. Finally, we briefly discuss the use of stated preference methods for developing "hedonic" value frameworks, and conclude with some recommendations in this area. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

NASA and COTS Electronics: Past Approach and Successes - Future Considerations

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.

2018-01-01

NASA has a long history of using commercial grade electronics in space. In this talk, a brief history of NASAâ's trends and approaches to commercial grade electronics focusing on processing and memory systems will be presented. This will include providing summary information on the space hazards to electronics as well as NASA mission trade space. We will also discuss developing recommendations for risk management approaches to Electrical, Electronic and Electromechanical (EEE) parts and reliability in space. The final portion of the talk will discuss emerging aerospace trends and the future for Commercial Off The Shelf (COTS) usage.

Research on inverse, hybrid and optimization problems in engineering sciences with emphasis on turbomachine aerodynamics: Review of Chinese advances

NASA Technical Reports Server (NTRS)

Liu, Gao-Lian

1991-01-01

Advances in inverse design and optimization theory in engineering fields in China are presented. Two original approaches, the image-space approach and the variational approach, are discussed in terms of turbomachine aerodynamic inverse design. Other areas of research in turbomachine aerodynamic inverse design include the improved mean-streamline (stream surface) method and optimization theory based on optimal control. Among the additional engineering fields discussed are the following: the inverse problem of heat conduction, free-surface flow, variational cogeneration of optimal grid and flow field, and optimal meshing theory of gears.

Dynamic Domains in Data Production Planning

NASA Technical Reports Server (NTRS)

Golden, Keith; Pang, Wanlin

2005-01-01

This paper discusses a planner-based approach to automating data production tasks, such as producing fire forecasts from satellite imagery and weather station data. Since the set of available data products is large, dynamic and mostly unknown, planning techniques developed for closed worlds are unsuitable. We discuss a number of techniques we have developed to cope with data production domains, including a novel constraint propagation algorithm based on planning graphs and a constraint-based approach to interleaved planning, sensing and execution.

Understanding neighbourhoods, communities and environments: new approaches for social work research.

PubMed

Holland, Sally; Burgess, Stephen; Grogan-Kaylor, Andy; Delva, Jorge

2010-06-01

This article discusses some new ways in which social work research can explore the interaction between neighbourhoods and child and adult wellbeing. The authors note that social work practices are often criticised for taking an individualistic approach and paying too little attention to the service user's environment. The article uses examples of research projects from Chile, the United States of America and Wales, to discuss the use of spatially oriented research methods for understanding neighbourhood factors. Quantitative, qualitative and mixed methods approaches that are particularly appropriate for investigating social work relevant topics are discussed in turn, including quantitative and qualitative uses for geographical information systems (GIS), hierarchical linear modelling (HLM) for analysing spatially clustered data and qualitative mobile interviews. The article continues with a discussion of the strengths and limitations of using spatially orientated research designs in social work research settings and concludes optimistically with suggestions for future directions in this area.

Evaluating Electronic Reference Services: Issues, Approaches and Criteria.

ERIC Educational Resources Information Center

Novotny, Eric

2001-01-01

Discussion of electronic library reference services focuses on an overview of the chief methodologies available for conducting assessments of electronic services. Highlights include quantitative measures and benchmarks, including equity and access; quality measures; behavioral aspects of quality, including librarian-patron interaction; and future…

Management of relapsed and refractory classical Hodgkin lymphoma in children and adolescents.

PubMed

Daw, Stephen; Wynn, Rob; Wallace, Hamish

2011-02-01

There are a number of options for salvage treatment in children and adolescents with relapsed and refractory classical Hodgkin Lymphoma. These include salvage with standard dose chemotherapy, high dose chemotherapy with autologous stem cell transplant, allogeneic stem cell transplant or other novel approach. Radiotherapy has an important role in the salvage of some patients as part of a combined modality approach. This review outlines these salvage approaches and discusses whether the evidence from paediatric studies justifies a risk-adapted approach to salvage for individual patients or whether all patients should receive consolidation with high dose chemotherapy and autologous stem cell transplantation, which is often described as standard salvage management in adults. The important prognostic factors and how these may be used to allocate patients to standard versus high dose chemotherapy regimens are discussed. The role of allogeneic transplantation, novel agents and late effects will also be discussed. © 2010 Blackwell Publishing Ltd.

Staff Considerations in Technical Services: The Chameleon Approach.

ERIC Educational Resources Information Center

Foster, Constance L.

1988-01-01

Discusses the need to cope effectively with technological transitions in library technical services and to plan for successful staff development. The areas discussed include changing job skills, financial planning, ergonomics, innovative partnerships, training, and an emphasis on human resources development. (21 references) (Author/CLB)

Evolving Concepts and Teaching Approaches In Tectonics and Sedimentation.

ERIC Educational Resources Information Center

Graham, Stephan Alan

1983-01-01

Discusses five recent advances in sedimentary tectonics, noting how they are incorporated into college curricula. Advances discussed include basin type, tectonic setting, facies analysis (in conjunction with basin type/setting), stratigraphic analysis of reflection seismic data, and quantitative analysis of subsidence histories of sedimentary…

Retraining the Modern Civil Engineer.

ERIC Educational Resources Information Center

Priscoli, Jerome Delli

1983-01-01

Discusses why modern engineering requires social science and the nature of planning. After these conceptional discussions, 12 practical tools which social science brings to engineering are reviewed. A tested approach to training engineers in these tools is then described. Tools include institutional analysis, policy profiling, and other impact…

Innovative Technologies for Multicultural Education Needs

ERIC Educational Resources Information Center

Ferdig, Richard E.; Coutts, Jade; DiPietro, Joseph; Lok, Benjamin; Davis, Niki

2007-01-01

Purpose: The purpose of this paper is to discuss several technology applications that are being used to address current problems or opportunities related to multicultural education. Design/methodology/approach: Five technology applications or technology-related projects are discussed, including a teacher education literacy tool, social networking…

Quality in End User Documentation.

ERIC Educational Resources Information Center

Morrison, Ronald

1994-01-01

Discusses quality in end-user documentation for computer applications and explains four approaches to improving quality in end-user documents. Highlights include online help, usability testing, technical writing elements, statistical approaches, and concepts relating to software quality that are also applicable to user manuals. (LRW)

Approaches to Ethics in International Business Education.

ERIC Educational Resources Information Center

Iyer, Gopalkrishnan R.

1999-01-01

Identifies major issues in international business ethics (such as cultural relativism and ethical imperialism) that should be addressed when incorporating ethics in international business education. Also discusses instructional approaches, including alternative ways of thinking about morality, philosophy versus practice, the ethical agent, and…

Optimization of coupled systems: A critical overview of approaches

NASA Technical Reports Server (NTRS)

Balling, R. J.; Sobieszczanski-Sobieski, J.

1994-01-01

A unified overview is given of problem formulation approaches for the optimization of multidisciplinary coupled systems. The overview includes six fundamental approaches upon which a large number of variations may be made. Consistent approach names and a compact approach notation are given. The approaches are formulated to apply to general nonhierarchic systems. The approaches are compared both from a computational viewpoint and a managerial viewpoint. Opportunities for parallelism of both computation and manpower resources are discussed. Recommendations regarding the need for future research are advanced.

Serving-Maids and Literacy: An Approach to Teaching Literacy through History and Music.

ERIC Educational Resources Information Center

Turner-Bisset, R.

2001-01-01

Presents a case study of an integrated approach to teaching history, literacy and music, in a Year 6 class. Suggests success was due to use of varied teaching approaches including storytelling, drama, singing and discussion. Emphasizes links between genuine historical tasks, and activities in the National Literacy Strategy. Suggests how music…

Novel Functional Genomics Approaches: A Promising Future in the Combat Against Plant Viruses.

PubMed

Fondong, Vincent N; Nagalakshmi, Ugrappa; Dinesh-Kumar, Savithramma P

2016-10-01

Advances in functional genomics and genome editing approaches have provided new opportunities and potential to accelerate plant virus control efforts through modification of host and viral genomes in a precise and predictable manner. Here, we discuss application of RNA-based technologies, including artificial micro RNA, transacting small interfering RNA, and Cas9 (clustered regularly interspaced short palindromic repeat-associated protein 9), which are currently being successfully deployed in generating virus-resistant plants. We further discuss the reverse genetics approach, targeting induced local lesions in genomes (TILLING) and its variant, known as EcoTILLING, that are used in the identification of plant virus recessive resistance gene alleles. In addition to describing specific applications of these technologies in plant virus control, this review discusses their advantages and limitations.

Experimental analysis of computer system dependability

NASA Technical Reports Server (NTRS)

Iyer, Ravishankar, K.; Tang, Dong

1993-01-01

This paper reviews an area which has evolved over the past 15 years: experimental analysis of computer system dependability. Methodologies and advances are discussed for three basic approaches used in the area: simulated fault injection, physical fault injection, and measurement-based analysis. The three approaches are suited, respectively, to dependability evaluation in the three phases of a system's life: design phase, prototype phase, and operational phase. Before the discussion of these phases, several statistical techniques used in the area are introduced. For each phase, a classification of research methods or study topics is outlined, followed by discussion of these methods or topics as well as representative studies. The statistical techniques introduced include the estimation of parameters and confidence intervals, probability distribution characterization, and several multivariate analysis methods. Importance sampling, a statistical technique used to accelerate Monte Carlo simulation, is also introduced. The discussion of simulated fault injection covers electrical-level, logic-level, and function-level fault injection methods as well as representative simulation environments such as FOCUS and DEPEND. The discussion of physical fault injection covers hardware, software, and radiation fault injection methods as well as several software and hybrid tools including FIAT, FERARI, HYBRID, and FINE. The discussion of measurement-based analysis covers measurement and data processing techniques, basic error characterization, dependency analysis, Markov reward modeling, software-dependability, and fault diagnosis. The discussion involves several important issues studies in the area, including fault models, fast simulation techniques, workload/failure dependency, correlated failures, and software fault tolerance.

Why Virtual, Why Environments? Implementing Virtual Reality Concepts in Computer-Assisted Language Learning.

ERIC Educational Resources Information Center

Schwienhorst, Klaus

2002-01-01

Discussion of computer-assisted language learning focuses on the benefits of virtual reality environments, particularly for foreign language contexts. Topics include three approaches to learner autonomy; supporting reflection, including self-awareness; supporting interaction, including collaboration; and supporting experimentation, including…

Experimental Investigation into the Fatigue Life of Hybrid Joints Under Fully Reversed Flexure Loading

DTIC Science & Technology

2008-06-01

joint classification 3 b. Hot spot-stress approach c. Notch-stress approach * d. Mesh-insensitive approach 2. Fracture mechanics (used for crack... classification approach, which is an adaptation of the nominal stress approach just discussed, with the welded joint fatigue curves as given in Table...used. More detail is provided on the joint classifications , and -- 19 I graphic representations are also included. It is explained that the stress

Diffuse-Interface Methods in Fluid Mechanics

NASA Technical Reports Server (NTRS)

Anderson, D. M.; McFadden, G. B.; Wheeler, A. A.

1997-01-01

The authors review the development of diffuse-interface models of hydrodynamics and their application to a wide variety of interfacial phenomena. The authors discuss the issues involved in formulating diffuse-interface models for single-component and binary fluids. Recent applications and computations using these models are discussed in each case. Further, the authors address issues including sharp-interface analyses that relate these models to the classical free-boundary problem, related computational approaches to describe interfacial phenomena, and related approaches describing fully-miscible fluids.

Semiconductor nanocrystal quantum dot synthesis approaches towards large-scale industrial production for energy applications

DOE PAGES

Hu, Michael Z.; Zhu, Ting

2015-12-04

This study reviews the experimental synthesis and engineering developments that focused on various green approaches and large-scale process production routes for quantum dots. Fundamental process engineering principles were illustrated. In relation to the small-scale hot injection method, our discussions focus on the non-injection route that could be scaled up with engineering stir-tank reactors. In addition, applications that demand to utilize quantum dots as "commodity" chemicals are discussed, including solar cells and solid-state lightings.

Developing a professional approach to work-based assessments in rheumatology.

PubMed

Haines, Catherine; Dennick, Reg; da Silva, José António P

2013-04-01

This chapter discusses how doctors in key European countries develop and maintain professional standards of clinical knowledge in their specialism, rheumatology, with particular reference to how they are assessed in the workplace. The authors discuss key educational theories related to learning and assessment, including experiential learning, reflective practice, how formative and summative assessments drive experiential learning and the essential principles of reliability and validity. This chapter also considers the challenge of ensuring that professional attitudes towards assessment and reflective practice are developed alongside cognitive and practical skills, with reference to current frameworks, including the UK and North America. The chapter lists, describes and explains the main summative assessments used in postgraduate medicine in the UK. We advocate the development of the professional reflective-practitioner attitude as the best way of approaching the range of work-based assessments that trainees need to engage in. Our account concludes by briefly discussing the barriers that may impede professional approaches to assessing competence in rheumatology. A summary states how individual practitioners may contribute to a more effective process in their roles as assessors and trainees. Copyright © 2013. Published by Elsevier Ltd.

Integrating molecular and morphological approaches for characterizing parasite cryptic species: implications for parasitology.

PubMed

Nadler, Steven A; DE León, Gerardo Pérez-Ponce

2011-11-01

Herein we review theoretical and methodological considerations important for finding and delimiting cryptic species of parasites (species that are difficult to recognize using traditional systematic methods). Applications of molecular data in empirical investigations of cryptic species are discussed from an historical perspective, and we evaluate advantages and disadvantages of approaches that have been used to date. Developments concerning the theory and practice of species delimitation are emphasized because theory is critical to interpretation of data. The advantages and disadvantages of different molecular methodologies, including the number and kind of loci, are discussed relative to tree-based approaches for detecting and delimiting cryptic species. We conclude by discussing some implications that cryptic species have for research programmes in parasitology, emphasizing that careful attention to the theory and operational practices involved in finding, delimiting, and describing new species (including cryptic species) is essential, not only for fully characterizing parasite biodiversity and broader aspects of comparative biology such as systematics, evolution, ecology and biogeography, but to applied research efforts that strive to improve development and understanding of epidemiology, diagnostics, control and potential eradication of parasitic diseases.

The Chinese House Game.

ERIC Educational Resources Information Center

Lee, James R.

1989-01-01

Discussion of the use of simulations to teach international relations (IR) highlights the Chinese House Game, a computer-based decision-making game based on Inter Nation Simulation (INS). Topics discussed include the increasing role of artificial intelligence in IR simulations, multi-disciplinary approaches, and the direction of IR as a…

Integrative approaches: promoting socioecological resilience

Treesearch

J.W. Long; Carl Skinner; M. North; C.T. Hunsaker; L. Quinn-Davidson

2014-01-01

This chapter begins by discussing current challenges for ecosystem management that emerged from multiple chapters of the full synthesis. It then considers integrative approaches to promote resilience, including general strategies that recognize the integrated nature of socioecological systems, the importance of promoting disturbance regimes upon which these systems...

DERMAL EXPOSURE ASSESSMENT: A SUMMARY OF EPA APPROACHES

EPA Science Inventory

This final report presents a concise description and evaluation of the approaches used in the Agency for dermal exposure assessment including a discussion about harmonization and research needs in this area. The report is intended to be used by EPA program offices in their effort...

Comparative Psychology: An Epigenetic Approach.

ERIC Educational Resources Information Center

Greenberg, Gary

1987-01-01

A comparative psychology course oriented around the themes of phylogeny and ontogeny is described. The course emphasizes the evolution and development of behavioral processes and includes a discussion of the concept of integrative levels and Schneirla's approach/withdrawal theory. The course evaluates genetic determinism and stresses the principle…

Ethical Dilemmas in Protecting Individual Rights Versus Public Protection in the Case of Infectious Diseases

PubMed Central

Phua, Kai-Lit

2013-01-01

Infectious diseases—including emerging and re-emerging diseases such as Ebola and tuberculosis—continue to be important causes of morbidity and mortality in the globalizing, contemporary world. This article discusses the ethical issues associated with protecting the rights of individuals versus the protection of the health of populations in the case of infectious diseases. The discussion uses the traditional medical ethics approach together with the public health approach presented by Faden and Shebaya.3 Infectious diseases such as Ebola hemorrhagic fever, Nipah virus and HIV/AIDS (together with tuberculosis) will be used to illustrate particular points in the discussion. PMID:24847171

Exercise countermeasures for spaceflight.

PubMed

Convertino, V A; Sandler, H

1995-01-01

The authors present a physiological basis for the use of exercise as a weightlessness countermeasure, outline special considerations for the development of exercise countermeasures, review and evaluate exercise used during space flight, and provide new approaches and concepts for the implementation of novel exercise countermeasures for future space flight. The discussion of the physiological basis for countermeasures examines maximal oxygen uptake, blood volume, metabolic responses to work, muscle function, bone loss, and orthostatic instability. The discussion of considerations for exercise prescriptions during space flight includes operational considerations, type of exercise, fitness considerations, age and gender, and psychological considerations. The discussion of exercise currently used in space flight examines cycle ergometry, the treadmill, strength training devices, electrical stimulation, and the Penguin suit worn by Russian crews. New approaches to exercise countermeasures include twin bicycles, dynamic resistance exercisers, maximal exercise effects, grasim (gravity simulators), and the relationship between exercise and LBNP.

Intelligent alarming

NASA Technical Reports Server (NTRS)

Braden, W. B.

1992-01-01

This talk discusses the importance of providing a process operator with concise information about a process fault including a root cause diagnosis of the problem, a suggested best action for correcting the fault, and prioritization of the problem set. A decision tree approach is used to illustrate one type of approach for determining the root cause of a problem. Fault detection in several different types of scenarios is addressed, including pump malfunctions and pipeline leaks. The talk stresses the need for a good data rectification strategy and good process models along with a method for presenting the findings to the process operator in a focused and understandable way. A real time expert system is discussed as an effective tool to help provide operators with this type of information. The use of expert systems in the analysis of actual versus predicted results from neural networks and other types of process models is discussed.

Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary.

PubMed

Boverhof, Darrell R; Ladics, Greg; Luebke, Bob; Botham, Jane; Corsini, Emanuela; Evans, Ellen; Germolec, Dori; Holsapple, Michael; Loveless, Scott E; Lu, Haitian; van der Laan, Jan Willem; White, Kimber L; Yang, Yung

2014-02-01

As experience is gained with toxicology testing and as new assays and technologies are developed, it is critical for stakeholders to discuss opportunities to advance our overall testing strategies. To facilitate these discussions, a workshop on practices for assessing immunotoxicity for environmental chemicals was held with the goal of sharing perspectives on immunotoxicity testing strategies and experiences, developmental immunotoxicity (DIT), and integrated and alternative approaches to immunotoxicity testing. Experiences across the chemical and pharmaceutical industries suggested that standard toxicity studies, combined with triggered-based testing approaches, represent an effective and efficient approach to evaluate immunotoxic potential. Additionally, discussions on study design, critical windows, and new guideline approaches and experiences identified important factors to consider before initiating DIT evaluations including assay choice and timing and the impact of existing adult data. Participants agreed that integrating endpoints into standard repeat-dose studies should be considered for fulfilling any immunotoxicity testing requirements, while also maximizing information and reducing animal use. Participants also acknowledged that in vitro evaluation of immunosuppression is complex and may require the use of multiple assays that are still being developed. These workshop discussions should contribute to developing an effective but more resource and animal efficient approach for evaluating chemical immunotoxicity. Copyright © 2013 Elsevier Inc. All rights reserved.

How to improve communication for the safe use of medicines?: Discussions on social marketing and patient-tailored approaches at the annual meetings of the WHO Programme for International Drug Monitoring.

PubMed

Bahri, Priya; Harrison-Woolrych, Mira

2012-12-01

Over the past decade, the annual meetings of national centres participating in the WHO Programme for International Drug Monitoring have increasingly included discussions on how to improve communication between national pharmacovigilance centres, patients, healthcare professionals, policy makers and the general public, with the aim of promoting the safe use of medicines. At the most recent meetings, working groups were dedicated to discuss possible applications and implementation of social marketing and patient-tailored approaches. This article provides the history and a summary of the recent discussions and recommendations to support progress in this respect at national and global level. Recommendations are made to investigate and pilot these approaches in small-scale projects at national pharmacovigilance centres. Applying elements from the social marketing and patient-tailored approaches to support behaviours of safe medicines use in patients and healthcare professionals should give the pharmacovigilance community new tools to achieve their goal to minimize risks with medicines and improve patient safety.

A Flight Evaluation of the Factors which Influence the Selection of Landing Approach Speeds

NASA Technical Reports Server (NTRS)

Drinkwater, Fred J., III; Cooper, George E.

1958-01-01

The factors which influence the selection of landing approach speeds are discussed from the pilot's point of view. Concepts were developed and data were obtained during a landing approach flight investigation of a large number of jet airplane configurations which included straight-wing, swept-wing, and delta-wing airplanes as well as several applications of boundary-layer control. Since the fundamental limitation to further reductions in approach speed on most configurations appeared to be associated with the reduction in the pilot's ability to control flight path angle and airspeed, this problem forms the basis of the report. A simplified equation is presented showing the basic parameters which govern the flight path angle and airspeed changes, and pilot control techniques are discussed in relation to this equation. Attention is given to several independent aerodynamic characteristics which do not affect the flight path angle or airspeed directly but which determine to a large extent the effort and attention required of the pilot in controlling these factors during the approach. These include stall characteristics, stability about all axes, and changes in trim due to thrust adjustments. The report considers the relationship between piloting technique and all of the factors previously mentioned. A piloting technique which was found to be highly desirable for control of high-performance airplanes is described and the pilot's attitudes toward low-speed flight which bear heavily on the selection of landing approach speeds under operational conditions are discussed.

Determining and Communicating the Value of the Special Library.

ERIC Educational Resources Information Center

Matthews, Joseph R.

2003-01-01

Discusses performance measures for libraries that will indicate the goodness of the library and its services. Highlights include a general evaluation model that includes input, process, output, and outcome measures; balanced scorecard approach that includes financial perspectives; focusing on strategy; strategies for change; user criteria for…

Nonlinear Attitude Filtering Methods

NASA Technical Reports Server (NTRS)

Markley, F. Landis; Crassidis, John L.; Cheng, Yang

2005-01-01

This paper provides a survey of modern nonlinear filtering methods for attitude estimation. Early applications relied mostly on the extended Kalman filter for attitude estimation. Since these applications, several new approaches have been developed that have proven to be superior to the extended Kalman filter. Several of these approaches maintain the basic structure of the extended Kalman filter, but employ various modifications in order to provide better convergence or improve other performance characteristics. Examples of such approaches include: filter QUEST, extended QUEST, the super-iterated extended Kalman filter, the interlaced extended Kalman filter, and the second-order Kalman filter. Filters that propagate and update a discrete set of sigma points rather than using linearized equations for the mean and covariance are also reviewed. A two-step approach is discussed with a first-step state that linearizes the measurement model and an iterative second step to recover the desired attitude states. These approaches are all based on the Gaussian assumption that the probability density function is adequately specified by its mean and covariance. Other approaches that do not require this assumption are reviewed, including particle filters and a Bayesian filter based on a non-Gaussian, finite-parameter probability density function on SO(3). Finally, the predictive filter, nonlinear observers and adaptive approaches are shown. The strengths and weaknesses of the various approaches are discussed.

Market Research Methods for Improving College Responsiveness.

ERIC Educational Resources Information Center

Larkin, Paul G.

1979-01-01

Essential elements of a good marketing plan for higher education institutions are described. What market research is and how the modern concept of marketing differs from the traditional sales approach are discussed as well as market analysis and definition. Also included is a discussion of marketing for proposed new programs. (Author/SF)

Can Canada Get Its Act Together in International Education?

ERIC Educational Resources Information Center

Farquhar, Robin H.

This paper discusses the position of Canada with regard to international education, drawing on the findings of a prior study intended to foster development of an agenda for promoting a more strategic national approach to the internationalization of Canadian education. International education, for the purposes of this discussion, includes extending…

Critical Discussion of Essentials of Diagnosis and Recording in Periodontics.

ERIC Educational Resources Information Center

Ellen, Richard P.

1994-01-01

Issues to be addressed before writing standards of care for the diagnosis of adult periodontal disease are discussed. These include considerations in screening and examination; arriving at diagnosis and prognosis, informing the patient, and referral; monitoring outcomes using diagnostic signs and tests; and new technology for and approaches to…

Environment, Development and the Child.

ERIC Educational Resources Information Center

United Nations Children's Fund, New York, NY.

This publication discusses the effects of the physical environment on the maturation of children in developing nations. Part 1 examines the conceptual framework of a strategy for environmental improvement that includes the social, economic, and political underpinnings necessary for the success of such an approach. Part 2 discusses the quality of…

76 FR 59395 - Notice of Webcast Meeting of the Environmental Financial Advisory Board (EFAB)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-26

... creative approaches to funding environmental programs, projects, and activities. The purpose of the meeting... priorities and to discuss progress with work projects under EFAB's current Strategic Action Agenda; and... topics expected to be discussed include: financing clean air technology; financing tribal environmental...

Prevention and Control of Stress among Emergency Workers: A Pamphlet for Workers.

ERIC Educational Resources Information Center

National Inst. of Mental Health (DHHS), Rockville, MD.

This pamphlet discusses approaches that have been found helpful to workers in dealing with disaster-related stress. It suggests interventions that may be helpful before, during, and after a disaster. Predisaster interventions are discussed. These include collaborative relationship between emergency and mental health services, orientation and…

Everything Is Connected: Giftedness within a Broad Framework for Cognition

ERIC Educational Resources Information Center

Woolcott, Geoff

2012-01-01

Ziegler and Phillipson (Z&P) have provided a valuable discussion of the identification and development of giftedness under a systemic umbrella, including issues of differing theoretical approaches and efficacy. This commentary considers their discussion within a novel systemic framework that links also individuals and environment, but in terms of…

Beyond A-Level in the Teaching of French.

ERIC Educational Resources Information Center

Sanders, Carol, Ed.

The papers in this volume discuss practical approaches to some of the current problems of degree-level language teaching. Section one discusses non-literary registers in advanced language teaching including the use of texts in teaching, suggestions for a course in practical sociolinguistics, and exercises for advancing from paraphrase to an…

Learning to Think in a Math Lab.

ERIC Educational Resources Information Center

Charbonneau, Manon P.

This document begins with a discussion of the author's approach to instruction in a mathematics laboratory. This discussion includes an enumeration of types of desirable or necessary equipment and advice on the management of a laboratory. The author examines issues related to achievement and readiness for more traditional school experiences in…

Counseling Older Japanese American Clients: An Overview and Observations.

ERIC Educational Resources Information Center

Itai, Goro; McRae, Cynthia

1994-01-01

Discusses important aspects of providing counseling to older Japanese American clients, including ethical issues based on cultural differences and nontraditional approaches to counseling. Examines unique historical and cultural characteristics of these clients. Includes 26 citations. (Author/CRR)

Structure and Modification of Electrode Materials for Protein Electrochemistry.

PubMed

Jeuken, Lars J C

The interactions between proteins and electrode surfaces are of fundamental importance in bioelectrochemistry, including photobioelectrochemistry. In order to optimise the interaction between electrode and redox protein, either the electrode or the protein can be engineered, with the former being the most adopted approach. This tutorial review provides a basic description of the most commonly used electrode materials in bioelectrochemistry and discusses approaches to modify these surfaces. Carbon, gold and transparent electrodes (e.g. indium tin oxide) are covered, while approaches to form meso- and macroporous structured electrodes are also described. Electrode modifications include the chemical modification with (self-assembled) monolayers and the use of conducting polymers in which the protein is imbedded. The proteins themselves can either be in solution, electrostatically adsorbed on the surface or covalently bound to the electrode. Drawbacks and benefits of each material and its modifications are discussed. Where examples exist of applications in photobioelectrochemistry, these are highlighted.

The Declining Suitability of the Formula Approach to Funding Fublic Higher Education: Rationale and Alternatives.

ERIC Educational Resources Information Center

Temple, Charles M.; Riggs, Robert O.

1978-01-01

After discussing and analyzing three available alternative budgeting approaches, including incremental, program budgeting, and zero-based budgeting, this article suggests the criteria necessary for a newly adapted system and contends that a program budgeting system would serve most effectively. (DS)

Learning from Multiple Collaborating Intelligent Tutors: An Agent-based Approach.

ERIC Educational Resources Information Center

Solomos, Konstantinos; Avouris, Nikolaos

1999-01-01

Describes an open distributed multi-agent tutoring system (MATS) and discusses issues related to learning in such open environments. Topics include modeling a one student-many teachers approach in a computer-based learning context; distributed artificial intelligence; implementation issues; collaboration; and user interaction. (Author/LRW)

Adult Learners: The University of Maryland Approach.

ERIC Educational Resources Information Center

Wolvin, Andrew D.

1991-01-01

Discusses the need to approach adult education differently from the teaching of children. Reminds educators that adult learners possess a wealth of experiences and distinctive job-related skills and needs. Describes the University of Maryland's adult education program, which includes a separate campus, courses at military installations, and…

The Reggio Emilia Approach and Inclusive Early Childhood Programs.

ERIC Educational Resources Information Center

Vakil, Shernavaz; Freeman, Ramona; Swim, Terry Jo

2003-01-01

Discusses benefits of inclusion in preschool and compares educational practices of high-quality inclusive preschools in the United States with those characterizing the Reggio Emilia approach. Offers recommendations for better serving children with special needs in inclusive settings, including viewing teachers as researchers, and using…

Three Lectures on Theorem-proving and Program Verification

NASA Technical Reports Server (NTRS)

Moore, J. S.

1983-01-01

Topics concerning theorem proving and program verification are discussed with particlar emphasis on the Boyer/Moore theorem prover, and approaches to program verification such as the functional and interpreter methods and the inductive assertion approach. A history of the discipline and specific program examples are included.

On the Use of Computers for Teaching Fluid Mechanics

NASA Technical Reports Server (NTRS)

Benson, Thomas J.

1994-01-01

Several approaches for improving the teaching of basic fluid mechanics using computers are presented. There are two objectives to these approaches: to increase the involvement of the student in the learning process and to present information to the student in a variety of forms. Items discussed include: the preparation of educational videos using the results of computational fluid dynamics (CFD) calculations, the analysis of CFD flow solutions using workstation based post-processing graphics packages, and the development of workstation or personal computer based simulators which behave like desk top wind tunnels. Examples of these approaches are presented along with observations from working with undergraduate co-ops. Possible problems in the implementation of these approaches as well as solutions to these problems are also discussed.

Safe-life and damage-tolerant design approaches for helicopter structures

NASA Technical Reports Server (NTRS)

Reddick, H. K., Jr.

1983-01-01

The safe-life and damage-tolerant design approaches discussed apply to both metallic and fibrous composite helicopter structures. The application of these design approaches to fibrous composite structures is emphasized. Safe-life and damage-tolerant criteria are applied to all helicopter flight critical components, which are generally categorized as: dynamic components with a main and tail rotor system, which includes blades, hub and rotating controls, and drive train which includes transmission, and main and interconnecting rotor shafts; and the airframe, composed of the fuselage, aerodynamic surfaces, and landing gear.

A discussion of approaches to transforming care: contemporary strategies to improve patient safety.

PubMed

Burston, Sarah; Chaboyer, Wendy; Wallis, Marianne; Stanfield, Jane

2011-11-01

This article presents a discussion of three contemporary approaches to transforming care: Transforming Care at the Bedside, Releasing Time to Care: the Productive Ward and the work of the Studer Group(®). International studies of adverse events in hospitals have highlighted the need to focus on patient safety. The case for transformational change was identified and recently several approaches have been developed to effect this change. Despite limited evaluation, these approaches have spread and have been adopted outside their country of origin and contextual settings. Medline and CINAHL databases were searched for the years 1999-2009. Search terms included derivatives of 'transformation' combined with 'care', 'nursing', 'patient safety', 'Transforming Care at the Bedside', 'the Productive Ward' and 'Studer Group'. A comparison of the three approaches revealed similarities including: the foci of the approaches; interventions employed; and the outcomes measured. Key differences identified are the implementation models used, spread strategies and sustainability of the approaches. The approaches appear to be complementary and a hybrid of the approaches such as a blend of a top-down and bottom-up leadership strategy may offer more sustainable behavioural change. These approaches transform the way nurses do their work, how they work with others and how they view the care they provide to promote patient safety. All the approaches involve the implementation of multiple interventions occurring simultaneously to affect improvements in patient safety. The approaches are complementary and a hybrid approach may offer more sustainable outcomes. © 2011 Blackwell Publishing Ltd.

A Librarian's Guide to Speaking the Business Language.

ERIC Educational Resources Information Center

Zach, Lisl

2002-01-01

Discusses budgeting in corporate libraries as a basic tool of financial management. Highlights include focusing on goals; developing a list or matrix of services; resources needed for each service; shared costs; types of budgets, including operating budget, capital budget, and cash budget; and approaches to budgeting, including incremental…

New Directions for Mathematics Instruction. 1989 Yearbook.

ERIC Educational Resources Information Center

Blume, Glendon W., Ed.; Heid, M. Kathleen, Ed.

This yearbook discusses instructional approaches that are consistent with the reformulation of the school mathematics curriculum by the National Council of Teachers of Mathematics (NCTM). Articles included cover: (1) Pennsylvania standards for mathematics programs (including goals, curriculum, instruction, evaluation, teachers, and…

Student and Instructor-Centered Approaches to Teaching Precalculus

ERIC Educational Resources Information Center

Davis, Tara C.; Lu', Hùng

2015-01-01

This paper describes the results of a two-semester-long study of the effects of student-centered instruction on Precalculus courses. We also describe our teaching approaches centering around students, which include a mixture of lectures, student presentations, group work, discussion, and guided investigations. Students were taught with either the…

Information and Communication Technology in the Israeli Educational System: Past, Present and Future.

ERIC Educational Resources Information Center

Katz, Yaacov J.

2002-01-01

Describes the development of the use of information and communication technology (ICT) in the Israeli educational system. Discusses a behaviorist approach to computer assisted instruction; open-ended courseware; constructivist approaches to multimedia, including simulations, modeling, and virtual reality; technology-based distance learning; and…

An Approach to Coping with Anxiety about AIDS.

ERIC Educational Resources Information Center

Krieger, Irwin

1988-01-01

Describes a stepwise counseling approach for assisting persons with heightened anxiety about Acquired Immune Deficiency Syndrome (AIDS) and ways to handle fears about the sexual transmission of AIDS. Five steps discussed include getting accurate information, assessing fear prior to exposure, learning to protect oneself and others, gathering peer…

Man and the Environment: The Need for a More Realistic Approach to Teaching Ecology.

ERIC Educational Resources Information Center

Evans, Stewart M.

1988-01-01

This article argues that Biology syllabi give insufficient attention to the role humans play in the ecological processes and interactions with their environment. Discussed are ecological studies in urban and managed habitats, using a multidisciplinary approach, and including a global perspective. (CW)

Addressing Equity within Science Education Courses: Sharing Approaches and Ideas.

ERIC Educational Resources Information Center

Wieseman, Katherine C.; Bryan, Lynn; Hammrich, Penny; Lynch, Sharon; McGinnis, Randy; Pyle, Eric

A discussion session provided opportunities for individuals involved in science teacher education to exchange approaches and ideas on how equity issues in science teaching and learning are being addressed in science teacher education courses. Evaluative questions included: (1) What conceptions of equity in science education underpin individual…

Teaching Methodologies for Population Education: Inquiry/Discovery Approach, Values Clarification.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

Divided into two sections, this booklet demonstrates how the discovery/inquiry approach and values clarification can be used to teach population education. Each part presents a theoretical discussion of a teaching method including its definition, its relevance to population education, some outstanding characteristics that make it suitable for…

An Instructional Approach to Modeling in Microevolution.

ERIC Educational Resources Information Center

Thompson, Steven R.

1988-01-01

Describes an approach to teaching population genetics and evolution and some of the ways models can be used to enhance understanding of the processes being studied. Discusses the instructional plan, and the use of models including utility programs and analysis with models. Provided are a basic program and sample program outputs. (CW)

An Approach to Ethics Utilizing the Experience of Women.

ERIC Educational Resources Information Center

Ferguson, Marianne

1996-01-01

Delineates a generalized difference between men and women in approaches to ethics. Reiterates Carol Gilligan's theory that men generally believe in a morality of rights whereas women subscribe to a morality of relationships. Discusses other aspects of this dichotomy including ideas of good, evil, and sin. (MJP)

Psychotherapy for Infertility: A Cognitive-Behavioral Approach for Couples.

ERIC Educational Resources Information Center

Myers, Lisa B.; Wark, Linda

1996-01-01

Describes a cognitive-behavioral model for treating couples' negative reactions to infertility. After a discussion of why the cognitive-behavioral approach can competently address the goals of couples coping with infertility, three phases of treatment are outlined: assessment, therapy, and closure. Areas for assessment include spouses, marital…

Structural and Multilingual Approaches to Subject Access on the Web.

ERIC Educational Resources Information Center

Chan, Lois Mai; Lin, Xia; Zeng, Marcia

This paper presents some of the efforts currently being made to develop mechanisms that can organize World Wide Web resources for efficient and effective retrieval, as well as programs that can accommodate multiple languages. Part 1 discusses structural approaches to organizing Web resources, including the use of hierarchical or…

Research in Distance Education: A System Modeling Approach.

ERIC Educational Resources Information Center

Saba, Farhad; Twitchell, David

1988-01-01

Describes how a computer simulation research method can be used for studying distance education systems. Topics discussed include systems research in distance education; a technique of model development using the System Dynamics approach and DYNAMO simulation language; and a computer simulation of a prototype model. (18 references) (LRW)

The NASA Monographs on Shell Stability Design Recommendations: A Review and Suggested Improvements

NASA Technical Reports Server (NTRS)

Nemeth, Michael P.; Starnes, James H., Jr.

1998-01-01

A summary of existing NASA design criteria monographs for the design of buckling-resistant thin-shell structures is presented. Subsequent improvements in the analysis for nonlinear shell response are reviewed, and current issues in shell stability analysis are discussed. Examples of nonlinear shell responses that are not included in the existing shell design monographs are presented, and an approach for including reliability based analysis procedures in the shell design process is discussed. Suggestions for conducting future shell experiments are presented, and proposed improvements to the NASA shell design criteria monographs are discussed.

The NASA Monographs on Shell Stability Design Recommendations: A Review and Suggested Improvements

NASA Technical Reports Server (NTRS)

Nemeth, Michael P.; Starnes, James H., Jr.

1998-01-01

A summary of the existing NASA design criteria monographs for the design of buckling-resistant thin-shell structures is presented. Subsequent improvements in the analysis for nonlinear shell response are reviewed, and current issues in shell stability analysis are discussed. Examples of nonlinear shell responses that are not included in the existing shell design monographs are presented, and an approach for including reliability-based analysis procedures in the shell design process is discussed. Suggestions for conducting future shell experiments are presented, and proposed improvements to the NASA shell design criteria monographs are discussed.

The early benefits of a problem-based approach to teaching social inclusion using an online virtual town.

PubMed

Beadle, Mary; Santy, Julie

2008-05-01

This article describes the delivery of a core pre-registration nursing and midwifery module centred on social inclusion. The module was previously delivered using a classroom-based problem-based learning approach. Difficulties with this approach led to changes to the module and its delivery. Logistic issues encouraged the module team to implement a blended learning approach using a virtual town to facilitate online learning and discussion activities. The paper describes and discusses the use of online learning technology to support student nurses and midwives. It highlights the benefits of this approach and outlines some of the experiences of the students including their evaluation of the virtual town. There is also an examination of some of the practical and theoretical issues related to both problem-based learning, online working and using a virtual town to support learning. This article outlines the approach taken and its implications.

Cotinine analytical workshop report: consideration of analytical methods for determining cotinine in human body fluids as a measure of passive exposure to tobacco smoke.

PubMed Central

Watts, R R; Langone, J J; Knight, G J; Lewtas, J

1990-01-01

A two-day technical workshop was convened November 10-11, 1986, to discuss analytical approaches for determining trace amounts of cotinine in human body fluids resulting from passive exposure to environmental tobacco smoke (ETS). The workshop, jointly sponsored by the U.S. Environmental Protection Agency and Centers for Disease Control, was attended by scientists with expertise in cotinine analytical methodology and/or conduct of human monitoring studies related to ETS. The workshop format included technical presentations, separate panel discussions on chromatography and immunoassay analytical approaches, and group discussions related to the quality assurance/quality control aspects of future monitoring programs. This report presents a consensus of opinion on general issues before the workshop panel participants and also a detailed comparison of several analytical approaches being used by the various represented laboratories. The salient features of the chromatography and immunoassay analytical methods are discussed separately. PMID:2190812

Stark laws and fair market value exceptions: an introduction.

PubMed

Siebrasse, Paul B

2007-01-01

This article will focus on one aspect of complexity in modern healthcare, namely the implications of Stark laws and other fraud and abuse provisions, including anti-kickback statutes and HIPAA. Also, this article explores the prevalence of fair market value as an exception in the Stark laws and discusses the meanings of those exceptions. Finally, the article explores basic approaches to assessing fair market value, including cost, income, and marketing approaches.

Imaginable Technologies for Human Missions to Mars

NASA Technical Reports Server (NTRS)

Bushnell, Dennis M.

2007-01-01

The thesis of the present discussion is that the simultaneous cost and inherent safety issues of human on-site exploration of Mars will require advanced-to-revolutionary technologies. The major crew safety issues as currently identified include reduced gravity, radiation, potentially extremely toxic dust and the requisite reliability for years-long missions. Additionally, this discussion examines various technological areas which could significantly impact Human-Mars cost and safety. Cost reductions for space access is a major metric, including approaches to significantly reduce the overall up-mass. Besides fuel, propulsion and power systems, the up-mass consists of the infrastructure and supplies required to keep humans healthy and the equipment for executing exploration mission tasks. Hence, the major technological areas of interest for potential cost reductions include propulsion, in-space and on-planet power, life support systems, materials and overall architecture, systems, and systems-of-systems approaches. This discussion is specifically offered in response to and as a contribution to goal 3 of the Presidential Exploration Vision: "Develop the Innovative Technologies Knowledge and Infrastructures both to explore and to support decisions about the destinations for human exploration".

Public acceptance for centralized storage and repositories of low-level waste session (Panel)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lutz, H.R.

1995-12-31

Participants from various parts of the world will provide a summary of their particular country`s approach to low-level waste management and the cost of public acceptance for low-level waste management facilities. Participants will discuss the number, geographic location, and type of low-level waste repositories and centralized storage facilities located in their countries. Each will discuss the amount, distribution, and duration of funds to gain public acceptance of these facilities. Participants will provide an estimated $/meter for centralized storage facilities and repositories. The panel will include a brief discussion about the ethical aspects of public acceptance costs, approaches for negotiating acceptance,more » and lessons learned in each country. The audience is invited to participate in the discussion.« less

Hierarchical models of very large problems, dilemmas, prospects, and an agenda for the future

NASA Technical Reports Server (NTRS)

Richardson, J. M., Jr.

1975-01-01

Interdisciplinary approaches to the modeling of global problems are discussed in terms of multilevel cooperation. A multilevel regionalized model of the Lake Erie Basin is analyzed along with a multilevel regionalized world modeling project. Other topics discussed include: a stratified model of interacting region in a world system, and the application of the model to the world food crisis in south Asia. Recommended research for future development of integrated models is included.

New Approaches to Final Cooling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuffer, David

2014-11-10

A high-energy muon collider scenario require a “final cooling” system that reduces transverse emittances by a factor of ~10 while allowing longitudinal emittance increase. The baseline approach has low-energy transverse cooling within high-field solenoids, with strong longitudinal heating. This approach and its recent simulation are discussed. Alternative approaches which more explicitly include emittance exchange are also presented. Round-to-flat beam transform, transverse slicing, and longitudinal bunch coalescence are possible components of the alternative approach. A more explicit understanding of solenoidal cooling beam dynamics is introduced.

The Thermodynamics of Black Holes.

PubMed

Wald, Robert M

2001-01-01

We review the present status of black hole thermodynamics. Our review includes discussion of classical black hole thermodynamics, Hawking radiation from black holes, the generalized second law, and the issue of entropy bounds. A brief survey also is given of approaches to the calculation of black hole entropy. We conclude with a discussion of some unresolved open issues.

EPA Workshop on Monitored Natural Attenuation for Inorganic Contaminants: 3 – Discussion of Specific Contaminants & Case Study

EPA Science Inventory

The purpose of this training is to present an overview of site characterization approaches to support evaluation of the potential for Monitored Natural Attenuation (MNA) as a remedy for inorganic contaminants in ground water. The training will include discussion of the types of ...

Preparing Coaches for the Changing Game of Science: Teaching in Multiple Domains.

ERIC Educational Resources Information Center

Dass, Pradeep M.

2000-01-01

Argues that traditional methods of science instruction are being supplanted by a broader approach that enhances understanding of the nature of science and teaches students to critically analyze scientific information. Discusses six domains of science to be included in good science instruction. Discusses ways new teachers can put those domains into…

Research on aviation fuel instability

NASA Technical Reports Server (NTRS)

Baker, C. E.; Bittker, D. A.; Cohen, S. M.; Seng, G. T.

1983-01-01

The underlying causes of fuel thermal degradation are discussed. Topics covered include: nature of fuel instability and its temperature dependence, methods of measuring the instability, chemical mechanisms involved in deposit formation, and instrumental methods for characterizing fuel deposits. Finally, some preliminary thoughts on design approaches for minimizing the effects of lowered thermal stability are briefly discussed.

PBTE (Performance-Based Teacher Education); Vol 2, No, 2, May 1973.

ERIC Educational Resources Information Center

Andrews, Theodore E., Ed.

This issue of the Multi-State Consortium for Performance-Based Teacher Education (PBTE) newsletter discusses (1) the evolutionary approach adopted by the state of Minnesota toward the implementation of PBTE, which includes discussion of what is known about PBTE, whether Minnesota ought (or wishes) to adopt the program, and state participation in…

The Challenges and Future of Public Higher Education Leadership in Kenya

ERIC Educational Resources Information Center

Odhiambo, George

2014-01-01

This article discusses some of the key challenges and points of tension pertaining to leadership in higher education in Kenya. Effective leadership approaches are discussed including an exploration of why effective leadership is more important in Kenyan public higher education now than ever. Given the complex context within which public higher…

Report of the 64th National Conference on Weights and Measures

NASA Astrophysics Data System (ADS)

Wollin, H. F.; Babeoq, L. E.; Heffernan, A. P.

1980-03-01

Major issues discussed at this conference include metric conversion in the United States, particularly the conversion of gasoline dispensers, problems relating to the quantity fill of packaged commodities especially as affected by moisture loss and statistical approach to package checking. Federal grain inspection, and a legal metrology control system are also discussed.

Portable non-invasive brain-computer interface: challenges and opportunities of optical modalities

NASA Astrophysics Data System (ADS)

Scholl, Clara A.; Hendrickson, Scott M.; Swett, Bruce A.; Fitch, Michael J.; Walter, Erich C.; McLoughlin, Michael P.; Chevillet, Mark A.; Blodgett, David W.; Hwang, Grace M.

2017-05-01

The development of portable non-invasive brain computer interface technologies with higher spatio-temporal resolution has been motivated by the tremendous success seen with implanted devices. This talk will discuss efforts to overcome several major obstacles to viability including approaches that promise to improve spatial and temporal resolution. Optical approaches in particular will be highlighted and the potential benefits of both Blood-Oxygen Level Dependent (BOLD) and Fast Optical Signal (FOS) will be discussed. Early-stage research into the correlations between neural activity and FOS will be explored.

Living Design Memory: Framework, Implementation, Lessons Learned.

ERIC Educational Resources Information Center

Terveen, Loren G.; And Others

1995-01-01

Discusses large-scale software development and describes the development of the Designer Assistant to improve software development effectiveness. Highlights include the knowledge management problem; related work, including artificial intelligence and expert systems, software process modeling research, and other approaches to organizational memory;…

Approaching Academic Digital Content Management.

ERIC Educational Resources Information Center

Acker, Stephen R.

2002-01-01

Discusses digital content management in higher education. Highlights include learning objects that make content more modular so it can be used in other courses or by other institutions; and a system at Ohio State University for content management that includes the creation of learner profiles. (LRW)

Alpha particle effects in burning tokamak plasmas: overview and specific examples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sigmar, D.J.

1986-07-01

Using the total power balance of an ignited tokamak plasma as a guideline, a range of alpha driven effects is surveyed regarding their impact on achieving and maintaining fusion burn. Specific examples of MHD and kinetic modes and multi species transport dynamics are discussed, including the possible interaction of these categories of effects. This power balance approach rather than a straightforward enumeration of possible effects serves to reveal their non-linear dependence and the ensuing fragility of our understanding of the approach to and maintenance of ignition. Specific examples are given of the interaction between ..cap alpha..-power driven sawtoothing and idealmore » MHD stability, and direct ..cap alpha..-effects on MHD modes including kinetic corrections. Anomalous ion heat transport and central impurity peaking mechanisms and anomalous and collisional ..cap alpha..-transport including the ambipolar electric field are discussed.« less

Psychosomatic approaches to obstetrics, gynaecology and andrology--a review.

PubMed

Lal, Mira

2009-01-01

This review aims to clarify the scope and clinical importance of psychosomatic approaches to obstetrics, gynaecology and andrology. This gradually expanding sub-specialty covers a wide domain of complex disease conditions that can be managed more effectively if the various biological, psychological and social aspects are recognised at the start and concurrent treatment initiated. The current need to practise biopsychosocial management of disease conditions is highlighted along with a description of what this would involve. The nine-field psychosomatic approach, which can be applied to everyday clinical encounters, has been illustrated. Clinical applications of the psychosomatic approach are discussed for various conditions including chronic pelvic pain, eating disorders, tokophobia, post-traumatic stress disorder, depression, menstrual disorders, infertility, bereavement and testicular cancer. Cultural considerations and the need for further research are also briefly discussed.

Wastewater treatment modelling in practice: a collaborative discussion of the state of the art.

PubMed

Phillips, H M; Sahlstedt, K E; Frank, K; Bratby, J; Brennan, W; Rogowski, S; Pier, D; Anderson, W; Mulas, M; Copp, J B; Shirodkar, N

2009-01-01

Three consulting teams conducted independent modelling projects for three different wastewater treatment plants ranging in size from approximately 113,800 m(3)/d (30 mgd) to 530,000 m(3)/d (140 mgd), in different parts of the world (USA and Finland). The plants have different treatment objectives ranging from nitrification and partial denitrification (nitrate plus nitrite <8.7 mg/L) to enhanced nutrient removal (total nitrogen <3 mg/L, total phosphorus <0.3 mg/L). Commonly-used models were applied in the case studies, including ASM3 (using the GPS-X simulator), New General (using GPS-X), Dold (using BioWin), and a variation of the Dold model methanol degradation capabilities (NGmeth within GPS-X). The authors compare and contrast the modelling approaches taken, including calibration and validation approaches, sensitivity analyses, and the application of results to full-scale studies, designs and operations. Despite several differences between the approaches, there are many similarities which are discussed in light of the IWA draft uniform protocol for activated sludge modelling. The authors also discuss current modelling limitations and offer suggestions to improve the state of the art.

Primary care providers' discussion of fall prevention approaches with their older adult patients-DocStyles, 2014.

PubMed

Burns, Elizabeth R; Haddad, Yara K; Parker, Erin M

2018-03-01

Falls are the leading cause of fatal and non-fatal injuries among older adults. The American and British Geriatric Societies recommend a fall risk assessment to identify risk factors and guide interventions to prevent these falls. This study describes the self-reported discussion of fall prevention approaches used by primary care providers (PCPs)-family practitioners, internists and nurse practitioners-who treat older adults. Results are described overall and by PCP type. We analyzed a sample of 1210 U.S. PCPs who participated in the 2014 DocStyles survey. PCPs reported on their recommendation of fall prevention approaches including general exercise, Tai Chi, medication adjustments, home safety modifications, vitamin D supplements, assistive devices, alarm systems, and referral to physical therapy, foot specialist, or vision specialist. Frequencies and adjusted odds ratios for fall prevention approaches were assessed by provider and practice characteristics. Self-reported discussion of any fall prevention approaches was 89.3%. Controlling for provider and practice characteristics, there were significant differences for some approaches by provider type. Family practitioners were more likely to suggest home modification [adjusted Odds Ratio: 1.8 (1.3-2.4)], exercise [aOR: 2.0 (1.5-2.5)], and Tai Chi [aOR: 1.5 (1.0-2.2)] than internists. Nurse practitioners were more likely to suggest home modification [aOR: 2.1 (1.3-3.4)] and less likely to suggest vitamin D [aOR: 0.6 (0.4-1.0)] than internists. Fall prevention suggestions vary by type of PCP. Dissemination of geriatric guidelines should include all PCPs who routinely see older adults.

The WWW and Our Digital Heritage--The New Preservation Tasks of the Library Community.

ERIC Educational Resources Information Center

Mannerheim, Johan

This paper discusses the role of libraries in the preservation of World Wide Web publications. Topics addressed include: (1) the scope of Web preservation, including examples of projects that illustrate comprehensive and selective approaches; (2) the responsibility of Web preservation, including placing the responsibility on publishers and other…

Gene Therapy for Advanced Melanoma: Selective Targeting and Therapeutic Nucleic Acids

PubMed Central

Viola, Joana R.; Rafael, Diana F.; Wagner, Ernst; Besch, Robert; Ogris, Manfred

2013-01-01

Despite recent advances, the treatment of malignant melanoma still results in the relapse of the disease, and second line treatment mostly fails due to the occurrence of resistance. A wide range of mutations are known to prevent effective treatment with chemotherapeutic drugs. Hence, approaches with biopharmaceuticals including proteins, like antibodies or cytokines, are applied. As an alternative, regimens with therapeutically active nucleic acids offer the possibility for highly selective cancer treatment whilst avoiding unwanted and toxic side effects. This paper gives a brief introduction into the mechanism of this devastating disease, discusses the shortcoming of current therapy approaches, and pinpoints anchor points which could be harnessed for therapeutic intervention with nucleic acids. We bring the delivery of nucleic acid nanopharmaceutics into perspective as a novel antimelanoma therapeutic approach and discuss the possibilities for melanoma specific targeting. The latest reports on preclinical and already clinical application of nucleic acids in melanoma are discussed. PMID:23634303

Different perspectives on economic base.

Treesearch

Lisa K. Crone; Richard W. Haynes; Nicholas E. Reyna

1999-01-01

Two general approaches for measuring the economic base are discussed. Each method is used to define the economic base for each of the counties included in the Interior Columbia Basin Ecosystem Management Project area. A more detailed look at four selected counties results in similar findings from different approaches. Limitations of economic base analysis also are...

A Hybrid Systems Approach to Preservation of Printed Materials.

ERIC Educational Resources Information Center

Willis, Don

Intended to stimulate thought and discussion, this report compares micrographics and digital imaging as tools for the preservation of printed materials. The topics covered include: (1) the advantages and disadvantages of each technology; (2) trade-offs involved in selecting one technology over another; (3) benefits of using a hybrid approach; (4)…

In Progress: Reports of New Approaches in Medical Education. Peer-Reviewed Collection of Reports on Innovative Approaches to Medical Education.

ERIC Educational Resources Information Center

Anderson, M. Brownell, Ed.

2002-01-01

Presents 24 articles describing innovative efforts in medical education in the areas of faculty development; developing skills as residents; and culture, ethics, spirituality, complementary, and alternative medicine. Each report includes an objective, description, discussion, and contact information for inquiries. (EV)

The Importance of Teaching Methodology in Moral Education of Sport Populations.

ERIC Educational Resources Information Center

Stoll, Sharon Kay; And Others

Three approaches to teaching moral reasoning were implemented by expert teachers in classes at three small colleges and outcomes were compared. Teaching models included the following: Model A, a "good reasoned" approach in which students discussed scenarios and determined the best course of action; Model B, a teacher-centered lecture,…

Requirements Engineering and Analysis Workshop Proceedings Held in Pittsburgh, Pennsylvania on 12-14 March 1991

DTIC Science & Technology

1991-12-01

urally. 6.5 Summary of Current or Potential Approaches Many approaches to context analysis were discussed by the group, including: * Causal Trees * SWOT ... Apple Computer, 1988 1 Aseltine, J., Beam, W.R., Palmer, J.D., Sage, A.P., 1989, Introduction To Computer Systems: Analysis, Design and Application

The Interpretive Approach to Religious Education: Challenging Thompson's Interpretation

ERIC Educational Resources Information Center

Jackson, Robert

2012-01-01

In a recent book chapter, Matthew Thompson makes some criticisms of my work, including the interpretive approach to religious education and the research and activity of Warwick Religions and Education Research Unit. Against the background of a discussion of religious education in the public sphere, my response challenges Thompson's account,…

Predelinquent Behavior in Males: Perspectives and Suggestions

ERIC Educational Resources Information Center

Cross, Herbert; Kohl, Marilyn

1978-01-01

Discusses several approaches for solving the problem of delinquency including Quay's empirical system, Warren's theoretical system, Hogan's theory of moral conduct, and Bandura's social learning theory. (Author/RK)

Training of Personnel to Work with Young Children in India.

ERIC Educational Resources Information Center

Kahalakdina, M.

1984-01-01

Describes recruitment procedures for child care workers in India. Includes a description of training programs, training needs and approaches, and curriculum and training procedures. Monitoring and evaluation of child welfare programs are discussed. Appendices include descriptions of and norms for training programs. (AS)

The GUI OPAC: Approach with Caution.

ERIC Educational Resources Information Center

Hildreth, Charles R.

1995-01-01

Discusses the graphical user interface (GUI) online public access catalog (OPAC), a user interface that uses images to represent options. Topics include user interface design for information retrieval; designing effective bibliographic displays, including subject headings; two design principles; and what GUIs can bring to OPACs. (LRW)

A New Approach To Secure Federated Information Bases Using Agent Technology.

ERIC Educational Resources Information Center

Weippi, Edgar; Klug, Ludwig; Essmayr, Wolfgang

2003-01-01

Discusses database agents which can be used to establish federated information bases by integrating heterogeneous databases. Highlights include characteristics of federated information bases, including incompatible database management systems, schemata, and frequently changing context; software agent technology; Java agents; system architecture;…

Neuroimaging mechanisms of change in psychotherapy for addictive behaviors: emerging translational approaches that bridge biology and behavior.

PubMed

Feldstein Ewing, Sarah W; Chung, Tammy

2013-06-01

Research on mechanisms of behavior change provides an innovative method to improve treatment for addictive behaviors. An important extension of mechanisms of change research involves the use of translational approaches, which examine how basic biological (i.e., brain-based mechanisms) and behavioral factors interact in initiating and sustaining positive behavior change as a result of psychotherapy. Articles in this special issue include integrative conceptual reviews and innovative empirical research on brain-based mechanisms that may underlie risk for addictive behaviors and response to psychotherapy from adolescence through adulthood. Review articles discuss hypothesized mechanisms of change for cognitive and behavioral therapies, mindfulness-based interventions, and neuroeconomic approaches. Empirical articles cover a range of addictive behaviors, including use of alcohol, cigarettes, marijuana, cocaine, and pathological gambling and represent a variety of imaging approaches including fMRI, magneto-encephalography, real-time fMRI, and diffusion tensor imaging. Additionally, a few empirical studies directly examine brain-based mechanisms of change, whereas others examine brain-based indicators as predictors of treatment outcome. Finally, two commentaries discuss craving as a core feature of addiction, and the importance of a developmental approach to examining mechanisms of change. Ultimately, translational research on mechanisms of behavior change holds promise for increasing understanding of how psychotherapy may modify brain structure and functioning and facilitate the initiation and maintenance of positive treatment outcomes for addictive behaviors. 2013 APA, all rights reserved

Neuroimaging mechanisms of change in psychotherapy for addictive behaviors: Emerging translational approaches that bridge biology and behavior

PubMed Central

Feldstein Ewing, Sarah W.; Chung, Tammy

2013-01-01

Research on mechanisms of behavior change provides an innovative method to improve treatment for addictive behaviors. An important extension of mechanisms of change research involves the use of translational approaches, which examine how basic biological (i.e., brain-based mechanisms) and behavioral factors interact in initiating and sustaining positive behavior change as a result of psychotherapy. Articles in this special issue include integrative conceptual reviews and innovative empirical research on brain-based mechanisms that may underlie risk for addictive behaviors and response to psychotherapy from adolescence through adulthood. Review articles discuss hypothesized mechanisms of change for cognitive and behavioral therapies, mindfulness-based interventions, and neuroeconomic approaches. Empirical articles cover a range of addictive behaviors, including use of alcohol, cigarettes, marijuana, cocaine, and pathological gambling and represent a variety of imaging approaches including fMRI, magneto-encephalography, real time fMRI, and diffusion tensor imaging. Additionally, a few empirical studies directly examined brain-based mechanisms of change, whereas others examined brain-based indicators as predictors of treatment outcome. Finally, two commentaries discuss craving as a core feature of addiction, and the importance of a developmental approach to examining mechanisms of change. Ultimately, translational research on mechanisms of behavior change holds promise for increasing understanding of how psychotherapy may modify brain structure and functioning and facilitate the initiation and maintenance of positive treatment outcomes for addictive behaviors. PMID:23815447

Palliative care in advanced dementia.

PubMed

Merel, Susan E; Merel, Susan; DeMers, Shaune; Vig, Elizabeth

2014-08-01

Because neurodegenerative dementias are progressive and ultimately fatal, a palliative approach focusing on comfort, quality of life, and family support can have benefits for patients, families, and the health system. Elements of a palliative approach include discussion of prognosis and goals of care, completion of advance directives, and a thoughtful approach to common complications of advanced dementia. Physicians caring for patients with dementia should formulate a plan for end-of-life care in partnership with patients, families, and caregivers, and be prepared to manage common symptoms at the end of life in dementia, including pain and delirium. Copyright © 2014 Elsevier Inc. All rights reserved.

Advances in structure elucidation of small molecules using mass spectrometry

PubMed Central

Fiehn, Oliver

2010-01-01

The structural elucidation of small molecules using mass spectrometry plays an important role in modern life sciences and bioanalytical approaches. This review covers different soft and hard ionization techniques and figures of merit for modern mass spectrometers, such as mass resolving power, mass accuracy, isotopic abundance accuracy, accurate mass multiple-stage MS(n) capability, as well as hybrid mass spectrometric and orthogonal chromatographic approaches. The latter part discusses mass spectral data handling strategies, which includes background and noise subtraction, adduct formation and detection, charge state determination, accurate mass measurements, elemental composition determinations, and complex data-dependent setups with ion maps and ion trees. The importance of mass spectral library search algorithms for tandem mass spectra and multiple-stage MS(n) mass spectra as well as mass spectral tree libraries that combine multiple-stage mass spectra are outlined. The successive chapter discusses mass spectral fragmentation pathways, biotransformation reactions and drug metabolism studies, the mass spectral simulation and generation of in silico mass spectra, expert systems for mass spectral interpretation, and the use of computational chemistry to explain gas-phase phenomena. A single chapter discusses data handling for hyphenated approaches including mass spectral deconvolution for clean mass spectra, cheminformatics approaches and structure retention relationships, and retention index predictions for gas and liquid chromatography. The last section reviews the current state of electronic data sharing of mass spectra and discusses the importance of software development for the advancement of structure elucidation of small molecules. Electronic supplementary material The online version of this article (doi:10.1007/s12566-010-0015-9) contains supplementary material, which is available to authorized users. PMID:21289855

Addressing the need for an infection prevention and control framework that incorporates the role of surveillance: a discussion paper.

PubMed

Mitchell, Brett G; Gardner, Anne

2014-03-01

To present a discussion on theoretical frameworks in infection prevention and control. Infection prevention and control programmes have been in place for several years in response to the incidence of healthcare-associated infections and their associated morbidity and mortality. Theoretical frameworks play an important role in formalizing the understanding of infection prevention activities. Discussion paper. A literature search using electronic databases was conducted for published articles in English addressing theoretical frameworks in infection prevention and control between 1980-2012. Nineteen papers that included a reference to frameworks were identified in the review. A narrative analysis of these papers was completed. Two models were identified and neither included the role of surveillance. To reduce the risk of acquiring a healthcare-associated infection, a multifaceted approach to infection prevention is required. One key component in this approach is surveillance. The review identified two infection prevention and control frameworks, yet these are rarely applied in infection prevention and control programmes. Only one framework considered the multifaceted approach required for infection prevention. It did not, however, incorporate the role of surveillance. We present a framework that incorporates the role of surveillance into a biopsychosocial approach to infection prevention and control. Infection prevention and control programmes and associated research are led primarily by nurses. There is a need for an explicit infection prevention and control framework incorporating the important role that surveillance has in infection prevention activities. This study presents one framework for further critique and discussion. © 2013 John Wiley & Sons Ltd.

Please Ask Gently: Using Culturally Targeted Communication Strategies to Initiate End-of-Life Care Discussions With Older Chinese Americans.

PubMed

Chi, Han-Lin; Cataldo, Janine; Ho, Evelyn Y; Rehm, Roberta S

2018-01-01

Health-care providers (HCPs) find facilitating end-of-life (EOL) care discussions challenging, especially with patients whose ethnicities differ from their own. Currently, there is little guidance on how to initiate and facilitate such discussions with older Chinese Americans (≥55 years) and their families. To explore communication strategies for HCPs to initiate EOL care discussions with older Chinese Americans in the San Francisco Bay Area. This qualitative (focused) ethnographic study included field observations and individual semistructured interviews with 14 community-dwelling older Chinese Americans who lived independently at home, 9 adult children, and 7 HCPs. Responses were analyzed using open coding, memos, and comparison across participants. The study participants emphasized the importance of assessing readiness for early EOL care discussions. All recommended using indirect communication approaches to determine older Chinese Americans' readiness. Indirect communication can be culturally targeted and applied at both system-wide (ie, health-care system) and individual (ie, HCP) levels. To institutionalize the practice, health-care facilities should implement EOL care discussion inquiries as part of routine during check-in or intake questionnaires. In individual practice, using depersonalized communication strategies to initiate the discussion was recommended to determine older Chinese Americans' readiness. Assessing readiness should be an essential and necessary action for early EOL care discussions. Culturally targeted assessment of older Chinese Americans includes using indirect communication approaches to initiate an EOL care discussion to determine their readiness. In addition to health-care system integration, providers should implement and evaluate proposed EOL discussion initiation prompts with their older Chinese American patients.

Approaches to lunar base life support

NASA Technical Reports Server (NTRS)

Brown, M. F.; Edeen, M. A.

1990-01-01

Various approaches to reliable, low maintenance, low resupply regenerative long-term life support for lunar base application are discussed. The first approach utilizes Space Station Freedom physiochemical systems technology which has closed air and water loops with approximately 99 and 90 percent closure respectively, with minor subsystem changes to the SSF baseline improving the level of water resupply for the water loop. A second approach would be a physiochemical system, including a solid waste processing system and improved air and water loop closure, which would require only food and nitrogen for resupply. A hybrid biological/physiochemical life support system constitutes the third alternative, incorporating some level of food production via plant growth into the life support system. The approaches are described in terms of mass, power, and resupply requirements; and the potential evolution of a small, initial outpost to a large, self-sustaining base is discussed.

1992 NASA Life Support Systems Analysis workshop

NASA Technical Reports Server (NTRS)

Evanich, Peggy L.; Crabb, Thomas M.; Gartrell, Charles F.

1992-01-01

The 1992 Life Support Systems Analysis Workshop was sponsored by NASA's Office of Aeronautics and Space Technology (OAST) to integrate the inputs from, disseminate information to, and foster communication among NASA, industry, and academic specialists. The workshop continued discussion and definition of key issues identified in the 1991 workshop, including: (1) modeling and experimental validation; (2) definition of systems analysis evaluation criteria; (3) integration of modeling at multiple levels; and (4) assessment of process control modeling approaches. Through both the 1991 and 1992 workshops, NASA has continued to seek input from industry and university chemical process modeling and analysis experts, and to introduce and apply new systems analysis approaches to life support systems. The workshop included technical presentations, discussions, and interactive planning, with sufficient time allocated for discussion of both technology status and technology development recommendations. Key personnel currently involved with life support technology developments from NASA, industry, and academia provided input to the status and priorities of current and future systems analysis methods and requirements.

Cost Differentials and the Treatment of Equipment Assets: An Analysis of Alternatives.

ERIC Educational Resources Information Center

Frohreich, Lloyd E.

This paper is a discussion of alternative state approaches to aiding and costing capital outlay programs, particularly equipment purchases for vocational programs. Equipment costs for vocational programs tend to be a larger proportion of the total costs than in other programs. The paper includes a discussion of such topics as the magnitude of…

78 FR 50404 - Advanced Scientific Computing Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-19

... for the exascale challenges charge. Tentative Agenda: Agenda will include discussion of the following: Exascale Challenges Workshop and preliminary list of most critical challenges, and technical approaches to...

Shuttle ku-band communications/radar technical concepts

NASA Technical Reports Server (NTRS)

Griffin, J. W.; Kelley, J. S.; Steiner, A. W.; Vang, H. A.; Zrubek, W. E.; Huth, G. K.

1985-01-01

Technical data on the Shuttle Orbiter K sub u-band communications/radar system are presented. The more challenging aspects of the system design and development are emphasized. The technical problems encountered and the advancements made in solving them are discussed. The radar functions are presented first. Requirements and design/implementation approaches are discussed. Advanced features are explained, including Doppler measurement, frequency diversity, multiple pulse repetition frequencies and pulse widths, and multiple modes. The communications functions that are presented include advances made because of the requirements for multiple communications modes. Spread spectrum, quadrature phase shift keying (QPSK), variable bit rates, and other advanced techniques are discussed. Performance results and conclusions reached are outlined.

Subsea approach to work systems development

NASA Technical Reports Server (NTRS)

Gernhardt, M. L.; Frisbie, F. R.; Brown, C. E.

1988-01-01

Self-contained undersea working environments with applications to space station EVA environments are discussed. Physiological limitations include decompression, inert gas narcosis, high-pressure nervous system, gas toxicity, and thermal limitations. Work task requirements include drilling support, construction, inspection, and repair. Work systems include hyperbaric diving, atmospheric work systems, tele-operated work systems, and hybrid systems. Each type of work system is outlined in terms of work capabilities, special interface requirements, and limitations. Various operational philosophies are discussed. The evolution of work systems in the subsea industry has been the result of direct operational experience in a competitive market.

Foreign Languages: Key Links in the Chain of Learning.

ERIC Educational Resources Information Center

Mead, Robert G., Jr., Ed.

The articles discuss the necessity of including foreign language as an integral part of the curriculum at all levels of instruction. The following chapters are included: "Elementary School Foreign Language: Key Link in the Chain of Learning" (rationale, innovations, immersion programs, and interdisciplinary approaches); "Foreign…

Streaming Media Technology: Laying the Foundations for Educational Change.

ERIC Educational Resources Information Center

Sircar, Jayanta

2000-01-01

Discussion of the delivery of multimedia using streaming technology focuses on its use in engineering education. Highlights include engineering education and instructional technology, including learning approaches based on cognitive development; differences between local and distance education; economic factors; and roles of Web-based streaming,…

Learning Systems in Post-Statutory Education

ERIC Educational Resources Information Center

Catherall, Paul

2008-01-01

This article examines the broad scope of systemised learning (e-learning) in post-statutory education. Issues for discussion include the origins and forms of learning systems, including technical and educational concepts and approaches, such as distributed and collaborative learning. The VLE (Virtual Learning Environment) is defined as the…

When Violence Threatens the Workplace: Personnel Issues.

ERIC Educational Resources Information Center

Willits, Robert L.

1997-01-01

Discusses violence in the workplace and suggests a three-tier approach to dealing with violence in libraries that focuses on personnel issues: (1) preventive measures, including applicant screening, supervisory training, and employee assistance programs; (2) threat management, including policy formation and legal action; and (3) crisis/post-trauma…

Collaborative Internet Learning.

ERIC Educational Resources Information Center

Tate, Joanne

This paper describes pioneering in the area of telecommunications and the use of the Internet across the curriculum in Australian schools through the I*EARN (International Education and Resource Network). Topics discussed include: (1) changes to the traditional learning approach and school structure, including the role of the teacher and resource…

The HPT Value Proposition in the Larger Improvement Arena.

ERIC Educational Resources Information Center

Wallace, Guy W.

2003-01-01

Discussion of human performance technology (HPT) emphasizes the key variable, which is the human variable. Highlights include the Ishikawa Diagram; human performance as one variable of process performance; collaborating with other improvement approaches; value propositions; and benefits to stakeholders, including real return on investments. (LRW)

Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary

PubMed Central

Wang, J; Johnson, T; Sahin, L; Tassinari, MS; Anderson, PO; Baker, TE; Bucci-Rechtweg, C; Burckart, GJ; Chambers, CD; Hale, TW; Johnson-Lyles, D; Nelson, RM; Nguyen, C; Pica-Branco, D; Ren, Z; Sachs, H; Sauberan, J; Zajicek, A; Ito, S; Yao, LP

2017-01-01

This report serves as a summary of a 2-day public workshop sponsored by the US Food and Drug Administration (FDA) to discuss the safety of drugs and biological products used during lactation. The aim of the workshop was to provide a forum to discuss the collection of data to inform the potential risks to breastfed infants with maternal use of medications during lactation. Discussions included the review of current approaches to collect data on medications used during lactation, and the considerations for future approaches to design and guide clinical lactation studies. This workshop is part of continuing efforts to raise the awareness of the public for women who choose to breastfeed their infants. PMID:28510297

Dynamics of on-orbit construction process

NASA Technical Reports Server (NTRS)

Chiou, J. C.; Alexander, S.; Natori, M. C.; Mikulas, M.; Park, K. C.

1991-01-01

The topics covered are presented in viewgraph form and include the following: problem definition and motivation; survey of current technology; focus problems; approach; progress/discussion; and future direction and anticipated results.

Safe Heliports Through Design and Planning. A Summary of FAA Research and Development

DTIC Science & Technology

1994-02-08

facilities. Instrument approach R&D is a major topic by itself. This topic is addressed by a number cf the documents discussed in this bibliography... approach . Heliport approach and departure flight profiles were recorded using a variety of subject pilots flying three different helicopters: a Hughes...OH-6, a Sikorsky S-76, and a Bell UH-1. 5 A total of 1217 data runs ( approaches or departures) were completed. These included 239 runs with the OH-6

Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop.

PubMed

Smith, Grace L; Ganz, Patricia A; Bekelman, Justin E; Chmura, Steven J; Dignam, James J; Efstathiou, Jason A; Jagsi, Reshma; Johnstone, Peter A; Steinberg, Michael L; Williams, Stephen B; Yu, James B; Zietman, Anthony L; Weichselbaum, Ralph R; Tina Shih, Ya-Chen

2017-03-01

Leaders in the oncology community are sounding a clarion call to promote "value" in cancer care decisions. Value in cancer care considers the clinical effectiveness, along with the costs, when selecting a treatment. To discuss possible solutions to the current obstacles to achieving value in the use of advanced technologies in oncology, the National Cancer Policy Forum of the National Academies of Sciences, Engineering, and Medicine held a workshop, "Appropriate Use of Advanced Technologies for Radiation Therapy and Surgery in Oncology" in July 2015. The present report summarizes the discussions related to radiation oncology. The workshop convened stakeholders, including oncologists, researchers, payers, policymakers, and patients. Speakers presented on key themes, including the rationale for a value discussion on advanced technology use in radiation oncology, the generation of scientific evidence for value of advanced radiation technologies, the effect of both scientific evidence and "marketplace" (or economic) factors on the adoption of technologies, and newer approaches to improving value in the practice of radiation oncology. The presentations were followed by a panel discussion with dialogue among the stakeholders. Challenges to generating evidence for the value of advanced technologies include obtaining contemporary, prospective, randomized, and representative comparative effectiveness data. Proposed solutions include the use of prospective registry data; integrating radiation oncology treatment, outcomes, and quality benchmark data; and encouraging insurance coverage with evidence development. Challenges to improving value in practice include the slow adoption of higher value and the de-adoption of lower value treatments. The proposed solutions focused on engaging stakeholders in iterative, collaborative, and evidence-based efforts to define value and promote change in radiation oncology practice. Recent examples of ongoing or successful responses to the discussed challenges were provided. Discussions of "value" have increased as a priority in the radiation oncology community. Practitioners in the radiation oncology community can play a critical role in promoting a value-oriented framework to approach radiation oncology treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

PADF RF localization experiments with multi-agent caged-MAV platforms

NASA Astrophysics Data System (ADS)

Barber, Christopher; Gates, Miguel; Selmic, Rastko; Al-Issa, Huthaifa; Ordonez, Raul; Mitra, Atindra

2011-06-01

This paper provides a summary of preliminary RF direction finding results generated within an AFOSR funded testbed facility recently developed at Louisiana Tech University. This facility, denoted as the Louisiana Tech University Micro- Aerial Vehicle/Wireless Sensor Network (MAVSeN) Laboratory, has recently acquired a number of state-of-the-art MAV platforms that enable us to analyze, design, and test some of our recent results in the area of multiplatform position-adaptive direction finding (PADF) [1] [2] for localization of RF emitters in challenging embedded multipath environments. Discussions within the segmented sections of this paper include a description of the MAVSeN Laboratory and the preliminary results from the implementation of mobile platforms with the PADF algorithm. This novel approach to multi-platform RF direction finding is based on the investigation of iterative path-loss based (i.e. path loss exponent) metrics estimates that are measured across multiple platforms in order to develop a control law that robotically/intelligently positionally adapt (i.e. self-adjust) the location of each distributed/cooperative platform. The body of this paper provides a summary of our recent results on PADF and includes a discussion on state-of-the-art Sensor Mote Technologies as applied towards the development of sensor-integrated caged-MAV platform for PADF applications. Also, a discussion of recent experimental results that incorporate sample approaches to real-time singleplatform data pruning is included as part of a discussion on potential approaches to refining a basic PADF technique in order to integrate and perform distributed self-sensitivity and self-consistency analysis as part of a PADF technique with distributed robotic/intelligent features. These techniques are extracted in analytical form from a parallel study denoted as "PADF RF Localization Criteria for Multi-Model Scattering Environments". The focus here is on developing and reporting specific approaches to self-sensitivity and self-consistency within this experimental PADF framework via the exploitation of specific single-agent caged-MAV trajectories that are unique to this experiment set.

Improving the quality of end-of-life discussions.

PubMed

Myers, Jeff

2015-03-01

This article provides an update on the recent research and evidence regarding quality in end-of-life (EOL) discussions with a focus on the care of a person with cancer. Clinicians have the challenging task of customizing the information exchange that occurs during an EOL discussion. Patients identify important stipulations that accompany a desire for frank EOL discussions. These include timing of the discussion, ensuring evaluation of readiness to engage in the EOL discussion, and being invited to participate. The timing of an EOL discussion is likely to be more important than the setting in which an EOL discussion occurs. Less than 1 month prior to a person's death is likely to be an inadequate amount of time to allow a patient to consider and reflect on his or her EOL preferences. Among those admitted to the hospital, delay in the timing of EOL discussions carries the risk of losing decision-making capacity. There is greater use of quality metrics as patient outcomes among studies examining EOL discussions. System-wide approaches to improving EOL discussions should include standardized documentation templates that are widely accessible in electronic medical records.

Automatic editing of manuals

NASA Technical Reports Server (NTRS)

Rich, R. P.

1970-01-01

The documentation problem is discussed that arises in getting all the many items included in a computer program prepared in a timely fashion and keeping them all correct and mutually consistent during the life of the program. The proposed approach to the problem is to collect all the necessary information into a single document, which is maintained with computer assistance during the life of the program and from which the required subdocuments can be extracted as desired. Implementation of this approach requires a package of programs for computer editorial assistance and is facilitated by certain programming practices that are discussed.

CFD Methods and Tools for Multi-Element Airfoil Analysis

NASA Technical Reports Server (NTRS)

Rogers, Stuart E.; George, Michael W. (Technical Monitor)

1995-01-01

This lecture will discuss the computational tools currently available for high-lift multi-element airfoil analysis. It will present an overview of a number of different numerical approaches, their current capabilities, short-comings, and computational costs. The lecture will be limited to viscous methods, including inviscid/boundary layer coupling methods, and incompressible and compressible Reynolds-averaged Navier-Stokes methods. Both structured and unstructured grid generation approaches will be presented. Two different structured grid procedures are outlined, one which uses multi-block patched grids, the other uses overset chimera grids. Turbulence and transition modeling will be discussed.

Meeting the challenge of a 50000-hour-life-time requirement

NASA Technical Reports Server (NTRS)

Vest, C. E.; Studer, P. A.

1971-01-01

Space mission requirements for the 70's have established a 50,000-hour-lifetime challenge for the mechanisms designer. This challenge may be met by two approaches: (1) development of new materials for wear-prone elements, and (2) design innovation of new electromechanical devices that do not include mechanical wear-prone components. Present state-of-the-art materials require restricted operation regarding load, speed, and power for gears, bearings, and brush-slipring components. These restrictions are discussed, and methods of improvement are suggested. The design-innovations approach is discussed and is illustrated by the design of an experimental magnetically suspended motor.

Dynamical Systems in Psychology: Linguistic Approaches

NASA Astrophysics Data System (ADS)

Sulis, William

Major goals for psychoanalysis and psychology are the description, analysis, prediction, and control of behaviour. Natural language has long provided the medium for the formulation of our theoretical understanding of behavior. But with the advent of nonlinear dynamics, a new language has appeared which offers promise to provide a quantitative theory of behaviour. In this paper, some of the limitations of natural and formal languages are discussed. Several approaches to understanding the links between natural and formal languages, as applied to the study of behavior, are discussed. These include symbolic dynamics, Moore's generalized shifts, Crutchfield's ɛ machines, and dynamical automata.

Diagnosis and Reconfiguration using Bayesian Networks: An Electrical Power System Case Study

NASA Technical Reports Server (NTRS)

Knox, W. Bradley; Mengshoel, Ole

2009-01-01

Automated diagnosis and reconfiguration are important computational techniques that aim to minimize human intervention in autonomous systems. In this paper, we develop novel techniques and models in the context of diagnosis and reconfiguration reasoning using causal Bayesian networks (BNs). We take as starting point a successful diagnostic approach, using a static BN developed for a real-world electrical power system. We discuss in this paper the extension of this diagnostic approach along two dimensions, namely: (i) from a static BN to a dynamic BN; and (ii) from a diagnostic task to a reconfiguration task. More specifically, we discuss the auto-generation of a dynamic Bayesian network from a static Bayesian network. In addition, we discuss subtle, but important, differences between Bayesian networks when used for diagnosis versus reconfiguration. We discuss a novel reconfiguration agent, which models a system causally, including effects of actions through time, using a dynamic Bayesian network. Though the techniques we discuss are general, we demonstrate them in the context of electrical power systems (EPSs) for aircraft and spacecraft. EPSs are vital subsystems on-board aircraft and spacecraft, and many incidents and accidents of these vehicles have been attributed to EPS failures. We discuss a case study that provides initial but promising results for our approach in the setting of electrical power systems.

The Biology of Behaviour.

ERIC Educational Resources Information Center

Broom, D. M.

1981-01-01

Discusses topics to aid in understanding animal behavior, including the value of the biological approach to psychology, functional systems, optimality and fitness, universality of environmental effects on behavior, and evolution of social behavior. (DS)

A Sensible Approach to Wireless Networking.

ERIC Educational Resources Information Center

Ahmed, S. Faruq

2002-01-01

Discusses radio frequency (R.F.) wireless technology, including industry standards, range (coverage) and throughput (data rate), wireless compared to wired networks, and considerations before embarking on a large-scale wireless project. (EV)

Tornadoes: A Center Approach.

ERIC Educational Resources Information Center

Christman-Rothlein, Liz; Meinbach, Anita M.

1981-01-01

Information is given on how to put together a learning center. Discusses information and activity packets for a complete learning center on tornadoes including objectives, directions, materials, photographs of physical arrangements, and posttest. (DC)

Adolescent Homosexual Behavior and the Health Educator.

ERIC Educational Resources Information Center

Chng, Chwee Lye

1980-01-01

Approaches for teaching about homosexuality as part of the school health curriculum are offered. Suggestions include discussion of popular values and stereotypes, teaching by example, and teaching through role playing. (JMF)

Recruiting Gamblers from the General Population for Research Purposes: Outcomes from Two Contrasting Approaches

ERIC Educational Resources Information Center

Williams, Jeremy D.; Pulford, Justin; Bellringer, Maria; Abbott, Max

2010-01-01

Multiple means exist by which gamblers including problem gamblers may be recruited from the general population for research survey purposes. However, there appears to be limited discussion in the published literature about the relative merits of one or other approach. This paper addresses this gap, in part, by reporting the experiences of…

Le Point sur L'immersion au Canada (The Argument for...Immersion in Canada).

ERIC Educational Resources Information Center

Rebuffot, Jacques

A discussion of French immersion education in Canada begins with a general examination of language immersion, including the historical context and social climate from which the immersion approach has grown in Canada, its beginnings in Quebec and spread throughout Canada, and the status of the approach in the United States, a number of European…

Remembering Parents in Parent-Mediated Early Intervention: An Approach to Examining Impact on Parents and Families

ERIC Educational Resources Information Center

Wainer, Allison L.; Hepburn, Susan; McMahon Griffith, Elizabeth

2017-01-01

The goal of this review is to advance the discussion regarding meaningful outcomes of early intervention for children with autism spectrum disorder. The rapid growth in the development and evaluation of early intervention approaches for autism spectrum disorder includes both therapist-driven and parent-mediated interventions. The majority of…

Defining the Scope of Prognosis: Primary Care Clinicians' Perspectives on Predicting the Future Health of Older Adults.

PubMed

Thomas, John M; Fried, Terri R

2018-05-01

Studies examining the attitudes of clinicians toward prognostication for older adults have focused on life expectancy prediction. Little is known about whether clinicians approach prognostication in other ways. To describe how clinicians approach prognostication for older adults, defined broadly as making projections about patients' future health. In five focus groups, 30 primary care clinicians from community-based, academic-affiliated, and Veterans Affairs primary care practices were given open-ended questions about how they make projections about their patients' future health and how this informs the approach to care. Content analysis was used to organize responses into themes. Clinicians spoke about future health in terms of a variety of health outcomes in addition to life expectancy, including independence in activities and decision making, quality of life, avoiding hospitalization, and symptom burden. They described approaches in predicting these health outcomes, including making observations about the overall trajectory of patients to predict health outcomes and recognizing increased risk for adverse health outcomes. Clinicians expressed reservations about using estimates of mortality risk and life expectancy to think about and communicate patients' future health. They discussed ways in which future research might help them in thinking about and discussing patients' future health to guide care decisions, including identifying when and whether interventions might impact future health. The perspectives of primary care clinicians in this study confirm that prognostic considerations can go beyond precise estimates of mortality risk and life expectancy to include a number of outcomes and approaches to predicting those outcomes. Published by Elsevier Inc.

Web-based teaching in nursing: lessons from the literature.

PubMed

Twomey, Angela

2004-08-01

Many in nurse education have partially adopted the Internet as a pedagogical approach. This has highlighted serious contentious issues for educators. These include, pedagogical vs. technological approaches to teaching, face-to-face vs. online communication and classroom vs. online teaching. This paper attempts to reassure educators about this new Internet-based pedagogy, by applying traditional educational theories and discussions on curriculum to web-based teaching. In particular, cognitive learning theories such as constructivism and the process model of curriculum development are discussed. These provide a solid theoretical framework from which to expand the Internet-based pedagogical approach among those whose interest is the promotion of learning. The paper concludes with the implications of web-based teaching for the personal and professional development of nurse educators.

The Theory and Art of Child Psychotherapy: A Corrective Developmental Approach.

PubMed

Friedman, Robert

2017-10-01

The history of child psychotherapy is sketched from the psychoanalytic pioneers Anna Freud and Melanie Klein to the popular "nondirective" approach of Virginia Axline. The author's approach to child psychotherapy, based on contemporary psychoanalytic theories, allows the therapist to play any parental role that helps to repair developmental deficiencies and conflicts. These include nurturing, supporting, mirroring, role modeling, challenging, and limit setting. Following Winnicott, psychotherapy is conceived as a play space in which therapist and child are both spontaneous. The value of interpretation and insight in child therapy is discussed. There follows a more detailed discussion of three major problem areas in child psychotherapy: handling anger and hostile aggression; handling issues related to sexuality; and handling narcissistic issues of inferiority and shame.

Reinvigorating Introductory Biology: A Theme-based, Investigative Approach To Teaching Biology Majors.

ERIC Educational Resources Information Center

Norton, Cynthia G.; Gildensoph, Lynne H.; Phillips, Martha M.; Wygal, Deborah D.; Olson, Kurt H.; Pellegrini, John J.; Tweeten, Kathleen A.

1997-01-01

Describes the reform of an introductory biology curriculum to reverse high attrition rates. Objectives include fostering self-directed learning, emphasizing process over content, and offering laboratory experiences that model the way to acquire scientific knowledge. Teaching methods include discussion, group mentoring, laboratory sections, and…

Interpersonal Skills Training in a Dental Setting: A Group Interaction Approach.

ERIC Educational Resources Information Center

Eigenbrode, Charles R.

1983-01-01

General curriculum emphases on behavioral science in the first- and second-year dental curriculum culminate in a course on doctor-patient relationships, preparatory to clinic activity. The course includes discussion and essay quizzes about videotape recordings of typical doctor-patient encounters. Topics and issues included are outlined. (MSE)

Operational health physics training

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1992-06-01

The initial four sections treat basic information concerning atomic structure and other useful physical quantities, natural radioactivity, the properties of {alpha}, {beta}, {gamma}, x rays and neutrons, and the concepts and units of radiation dosimetry (including SI units). Section 5 deals with biological effects and the risks associated with radiation exposure. Background radiation and man-made sources are discussed next. The basic recommendations of the ICRP concerning dose limitations: justification, optimization (ALARA concepts and applications) and dose limits are covered in Section seven. Section eight is an expanded version of shielding, and the internal dosimetry discussion has been extensively revised tomore » reflect the concepts contained in the MIRD methodology and ICRP 30. The remaining sections discuss the operational health physics approach to monitoring radiation. Individual sections include radiation detection principles, instrument operation and counting statistics, health physics instruments and personnel monitoring devices. The last five sections deal with the nature of, operation principles of, health physics aspects of, and monitoring approaches to air sampling, reactors, nuclear safety, gloveboxes and hot cells, accelerators and x ray sources. Decontamination, waste disposal and transportation of radionuclides are added topics. Several appendices containing constants, symbols, selected mathematical topics, and the Chart of the Nuclides, and an index have been included.« less

Electronic measurement of variable torques in precision work technology

NASA Technical Reports Server (NTRS)

Maehr, M.

1978-01-01

Approaches for the determination of torques on the basis of length measurements are discussed. Attention is given to torque determinations in which the deformation of a shaft is measured, an electric measurement of the torsion angle, and an approach proposed by Buschmann (1970). Methods for a torque determination conducted with the aid of force measurements make use of piezoelectric approaches. The components used by these methods include a quartz crystal and a charge amplifier.

Engaging Focus Group Methodology: The 4-H Middle School-Aged Youth Learning and Leading Study

ERIC Educational Resources Information Center

Scott, Siri; Grant, Samantha; Nippolt, Pamela Larson

2015-01-01

With young people, discussing complex issues such as learning and leading in a focus group can be a challenge. To help prime youth for the discussion, we created a focus group approach that featured a fun, interactive activity. This article includes a description of the focus group activity, lessons learned, and suggestions for additional…

Discussion boards: boring no more!

PubMed

Adelman, Deborah S; Nogueras, Debra J

2013-01-01

Creating discussion boards (DBs) that capture student imaginations and contain meaningful interactions can be a difficult process. Traditional DBs use a question-and-answer format that often is boring for both the student and instructor. The authors present creative approaches to DBs that result in lively debates and student-to-student and student-to-faculty interactions, including role playing, blogging, wikis, and the use of voice.

Considerations for IEL Courseware Design and the Next Generation of E-Learning

ERIC Educational Resources Information Center

Sözcü, Ömer Faruk; Ipek, Ismail

2013-01-01

The purpose of this study is to discuss strategies for developing integrated e-learning (IEL) courseware based on instructional design and technology (IDT) models and approaches as well as new discussions of e-learning. For this purpose, the study begins with the selection of one or more IDT models to conduct an e-courseware design including IEL…

Luminescence nanothermometry

NASA Astrophysics Data System (ADS)

Jaque, Daniel; Vetrone, Fiorenzo

2012-07-01

The current status of luminescence nanothermometry is reviewed in detail. Based on the main parameters of luminescence including intensity, bandwidth, bandshape, polarization, spectral shift and lifetime, we initially describe and compare the different classes of luminescence nanothermometry. Subsequently, the various luminescent materials used in each case are discussed and the mechanisms at the root of the luminescence thermal sensitivity are described. The most important results obtained in each case are summarized and the advantages and disadvantages of these approaches are discussed.The current status of luminescence nanothermometry is reviewed in detail. Based on the main parameters of luminescence including intensity, bandwidth, bandshape, polarization, spectral shift and lifetime, we initially describe and compare the different classes of luminescence nanothermometry. Subsequently, the various luminescent materials used in each case are discussed and the mechanisms at the root of the luminescence thermal sensitivity are described. The most important results obtained in each case are summarized and the advantages and disadvantages of these approaches are discussed. This work was supported by the Universidad Autónoma de Madrid and Comunidad Autónoma de Madrid (Project S2009/MAT-1756), by the Spanish Ministerio de Educacion y Ciencia (MAT2010-16161) and by Caja Madrid Foundation.

Numerical simulation for horizontal subsurface flow constructed wetlands: A short review including geothermal effects and solution bounding in biodegradation procedures

NASA Astrophysics Data System (ADS)

Liolios, K.; Tsihrintzis, V.; Angelidis, P.; Georgiev, K.; Georgiev, I.

2016-10-01

Current developments on modeling of groundwater flow and contaminant transport and removal in the porous media of Horizontal Subsurface Flow Constructed Wetlands (HSF CWs) are first reviewed in a short way. The two usual environmental engineering approaches, the black-box and the process-based one, are briefly presented. Next, recent research results obtained by using these two approaches are briefly discussed as application examples, where emphasis is given to the evaluation of the optimal design and operation parameters concerning HSF CWs. For the black-box approach, the use of Artificial Neural Networks is discussed for the formulation of models, which predict the removal performance of HSF CWs. A novel mathematical prove is presented, which concerns the dependence of the first-order removal coefficient on the Temperature and the Hydraulic Residence Time. For the process-based approach, an application example is first discussed which concerns procedures to evaluate the optimal range of values for the removal coefficient, dependent on either the Temperature or the Hydraulic Residence Time. This evaluation is based on simulating available experimental results of pilot-scale units operated in Democritus University of Thrace, Xanthi, Greece. Further, in a second example, a novel enlargement of the system of Partial Differential Equations is presented, in order to include geothermal effects. Finally, in a third example, the case of parameters uncertainty concerning biodegradation procedures is considered and the use of upper and a novel approach is presented, which concerns the upper and the lower solution bound for the practical draft design of HSF CWs.

Galileo Jupiter approach orbit determination

NASA Technical Reports Server (NTRS)

Miller, J. K.; Nicholson, F. T.

1984-01-01

Orbit determination characteristics of the Jupiter approach phase of the Galileo mission are described. Predicted orbit determination performance is given for the various mission events that occur during Jupiter approach. These mission events include delivery of an atmospheric entry probe, acquisition of probe science data by the Galileo orbiter for relay to earth, delivery of an orbiter to a close encounter of the Galilean satellite Io, and insertion of the orbiter into orbit about Jupiter. The orbit determination strategy and resulting accuracies are discussed for the data types which include Doppler, range, optical imaging of Io, and a new Very Long Baseline Interferometry (VLBI) data type called Differential One-Way Range (DOR).

Survey of methods for soil moisture determination

NASA Technical Reports Server (NTRS)

Schmugge, T. J.; Jackson, T. J.; Mckim, H. L.

1979-01-01

Existing and proposed methods for soil moisture determination are discussed. These include: (1) in situ investigations including gravimetric, nuclear, and electromagnetic techniques; (2) remote sensing approaches that use the reflected solar, thermal infrared, and microwave portions of the electromagnetic spectrum; and (3) soil physics models that track the behavior of water in the soil in response to meteorological inputs (precipitation) and demands (evapotranspiration). The capacities of these approaches to satisfy various user needs for soil moisture information vary from application to application, but a conceptual scheme for merging these approaches into integrated systems to provide soil moisture information is proposed that has the potential for meeting various application requirements.

Applying GRADE-CERQual to qualitative evidence synthesis findings: introduction to the series.

PubMed

Lewin, Simon; Booth, Andrew; Glenton, Claire; Munthe-Kaas, Heather; Rashidian, Arash; Wainwright, Megan; Bohren, Meghan A; Tunçalp, Özge; Colvin, Christopher J; Garside, Ruth; Carlsen, Benedicte; Langlois, Etienne V; Noyes, Jane

2018-01-25

The GRADE-CERQual ('Confidence in the Evidence from Reviews of Qualitative research') approach provides guidance for assessing how much confidence to place in findings from systematic reviews of qualitative research (or qualitative evidence syntheses). The approach has been developed to support the use of findings from qualitative evidence syntheses in decision-making, including guideline development and policy formulation. Confidence in the evidence from qualitative evidence syntheses is an assessment of the extent to which a review finding is a reasonable representation of the phenomenon of interest. CERQual provides a systematic and transparent framework for assessing confidence in individual review findings, based on consideration of four components: (1) methodological limitations, (2) coherence, (3) adequacy of data, and (4) relevance. A fifth component, dissemination (or publication) bias, may also be important and is being explored. As with the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach for effectiveness evidence, CERQual suggests summarising evidence in succinct, transparent, and informative Summary of Qualitative Findings tables. These tables are designed to communicate the review findings and the CERQual assessment of confidence in each finding. This article is the first of a seven-part series providing guidance on how to apply the CERQual approach. In this paper, we describe the rationale and conceptual basis for CERQual, the aims of the approach, how the approach was developed, and its main components. We also outline the purpose and structure of this series and discuss the growing role for qualitative evidence in decision-making. Papers 3, 4, 5, 6, and 7 in this series discuss each CERQual component, including the rationale for including the component in the approach, how the component is conceptualised, and how it should be assessed. Paper 2 discusses how to make an overall assessment of confidence in a review finding and how to create a Summary of Qualitative Findings table. The series is intended primarily for those undertaking qualitative evidence syntheses or using their findings in decision-making processes but is also relevant to guideline development agencies, primary qualitative researchers, and implementation scientists and practitioners.

Negotiating policy in practice: child and family health nurses' approach to the process of postnatal psychosocial assessment.

PubMed

Rollans, Mellanie; Schmied, Virginia; Kemp, Lynn; Meade, Tanya

2013-04-08

There is growing recognition internationally of the need to identify women with risk factors for poor perinatal mental health in pregnancy and following birth. In the state of New South Wales, Australia the Supporting Families Early policy provides a framework of assessment and support for women and families and includes routine psychosocial assessment and depression screening. This study investigated the approach taken by Child and Family Health Nurses (CFHNs) following birth to assessment and screening as recommended by state policy. This was a qualitative ethnographic study that included 83 CFHN and 20 women. Observations occurred with thirteen nurses; with 20 women, in the home or the clinic environment. An additional 70 nurses participated in discussion groups. An observational tool (4D&4R) and field notes were used to record observations and analysed descriptively using frequencies. Field notes, interview data and discussion group transcripts were analysed thematically. This was a qualitative ethnographic study that included 83 CFHN and 20 women. Observations occurred with thirteen nurses; with 20 women, in the home or the clinic environment. An additional 70 nurses participated in discussion groups. An observational tool (4D&4R) and field notes were used to record observations and analysed descriptively using frequencies. Field notes, interview data and discussion group transcripts were analysed thematically. CFHNs demonstrated a range of approaches to assessment and screening. Psychosocial assessment was conducted in 50% (10 out of the 20) of the interactions observed; however, all the women were screened using the Edinburgh Depression Scale. Four major themes that represent the approach taken to the assessment process were identified: 'Engagement: getting that first bit right', 'Doing some paperwork', 'Creating comfort' and 'Psychosocial assessment: doing it another way'. Nurses utilised other skills such as observing the women interacting with their baby, taking note of non verbal communication and using intuition to develop a clinical decision. Overall, nurses' took a sensitive and caring approach to assessment and screening, however, there were differences in interpretations of the policy recommendations across the two sites. Nurses adopt a flexible, relationship-based approach to the assessment process; however, they experience tension when required to incorporate structured psychosocial assessment processes. To undertake assessment and screening effectively, CFHNs require ongoing support, training and supervision to maintain this sensitive and emotionally challenging work.

Establishing a profitable skin care practice in a facial plastic surgery office.

PubMed

Cortez, Edwin A

2010-11-01

Facial plastic surgeons seeking information about establishing and maintaining a first-rate skin care program and practice in their office will learn practice management tips and business advice. This content begins with presenting steps in patient evaluation and continues through development of a care plan. Discussion includes approach to skin care products, sunscreen, and related preventive and restorative methods. Detailed discussion is included of developing a personalized skin care plan. The content concludes with essential business tips and marketing advice for the facial plastic surgeon to include skin care in the surgical practice, including the way in which these are handled in the author's practice. Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical Process Design: An Integrated Teaching Approach.

ERIC Educational Resources Information Center

Debelak, Kenneth A.; Roth, John A.

1982-01-01

Reviews a one-semester senior plant design/laboratory course, focusing on course structure, student projects, laboratory assignments, and course evaluation. Includes discussion of laboratory exercises related to process waste water and sludge. (SK)

Employee Wellness: A Cost-Saving Approach.

ERIC Educational Resources Information Center

Friedman, Glenn

1987-01-01

Employee ill health causes high health costs. Employee "wellness" programs are instrumental in helping control rising health costs. Presents discussion on how to develop effective wellness programs and their benefits. Includes an employee survey. (MD)

OXIDATIVE TREATMENT OF INDUSTRIAL WASTEWATER

EPA Science Inventory

This paper defines industrial waste treatment process as falling into categories of oxidative destruction, reductive destruction, and non-destructive, separation operations. The various oxidative approaches, including biological, chemical and thermal methods, are then discussed i...

Molecular approaches for classifying endometrial carcinoma.

PubMed

Piulats, Josep M; Guerra, Esther; Gil-Martín, Marta; Roman-Canal, Berta; Gatius, Sonia; Sanz-Pamplona, Rebeca; Velasco, Ana; Vidal, August; Matias-Guiu, Xavier

2017-04-01

Endometrial carcinoma is the most common cancer of the female genital tract. This review article discusses the usefulness of molecular techniques to classify endometrial carcinoma. Any proposal for molecular classification of neoplasms should integrate morphological features of the tumors. For that reason, we start with the current histological classification of endometrial carcinoma, by discussing the correlation between genotype and phenotype, and the most significant recent improvements. Then, we comment on some of the possible flaws of this classification, by discussing also the value of molecular pathology in improving them, including interobserver variation in pathologic interpretation of high grade tumors. Third, we discuss the importance of applying TCGA molecular approach to clinical practice. We also comment on the impact of intratumor heterogeneity in classification, and finally, we will discuss briefly, the usefulness of TCGA classification in tailoring immunotherapy in endometrial cancer patients. We suggest combining pathologic classification and the surrogate TCGA molecular classification for high-grade endometrial carcinomas, as an option to improve assessment of prognosis. Copyright © 2016 Elsevier Inc. All rights reserved.

Managing External Relations: The Lifeblood of Mission Success

NASA Technical Reports Server (NTRS)

Dumbacher, Daniel L.

2007-01-01

The slide presentation examines the role of customer and stakeholder relations in the success of space missions. Topics include agency transformation; an overview of project and program experience with a discussion of positions, technical accomplishments, and management lessons learned; and approaches to project success with emphasis on communication. Projects and programs discussed include the Space Shuttle Main Engine System, DC-XA Flight Demonstrator, X-33 Flight Demonstrator, Space Launch Initiative/2nd Generation Reusable Launch Vehicle, X-37 Flight Demonstrator, Constellation (pre Dr. Griffin), Safety and Mission Assurance, and Exploration Launch Projects.

Next-Generation Technologies for Multiomics Approaches Including Interactome Sequencing

PubMed Central

Ohashi, Hiroyuki; Miyamoto-Sato, Etsuko

2015-01-01

The development of high-speed analytical techniques such as next-generation sequencing and microarrays allows high-throughput analysis of biological information at a low cost. These techniques contribute to medical and bioscience advancements and provide new avenues for scientific research. Here, we outline a variety of new innovative techniques and discuss their use in omics research (e.g., genomics, transcriptomics, metabolomics, proteomics, and interactomics). We also discuss the possible applications of these methods, including an interactome sequencing technology that we developed, in future medical and life science research. PMID:25649523

A Toolbox for Imaging Stellar Surfaces

NASA Astrophysics Data System (ADS)

Young, John

2018-04-01

In this talk I will review the available algorithms for synthesis imaging at visible and infrared wavelengths, including both gray and polychromatic methods. I will explain state-of-the-art approaches to constraining the ill-posed image reconstruction problem, and selecting an appropriate regularisation function and strength of regularisation. The reconstruction biases that can follow from non-optimal choices will be discussed, including their potential impact on the physical interpretation of the results. This discussion will be illustrated with example stellar surface imaging results from real VLTI and COAST datasets.

Experiment S-191 visible and infrared spectrometer

NASA Technical Reports Server (NTRS)

Linnell, E. R.

1974-01-01

The design, development, fabrication test, and utilization of the visible and infrared spectrometer portion of the S-191 experiment, part of the Earth Resources Experiment Package, on board Skylab is discussed. The S-191 program is described, as well as conclusions and recommendations for improvement of this type of instrument for future applications. Design requirements, instrument design approaches, and the test verification program are presented along with test results, including flight hardware calibration data. A brief discussion of operation during the Skylab mission is included. Documentation associated with the program is listed.

Is there a Mediterranean bioethics?

PubMed

Mallia, Pierre

2012-11-01

Is there a special Mediterranean approach to Bioethics and if so what are the roots of this approach? And why not a Bosphorus, or a 'lake Michigan' bioethics? The answer to such a question depends on the focus one takes on defining 'Mediterranean'? On the one hand one can refer to the Mediterranean region which includes the surrounding coasts, having Europe on its northern coast line, northern Africa on its southern coast line (and these will include the north and South West coasts), and in the Eastern region countries which border with Middle-Eastern countries. This approach is the approach currently being taken by European Parliamentarians when they speak about the Mediterranean, namely including countries like France, Italy and Libya. On the other hand there is the look upon the Mediterranean as 'Southern Europe'; this is a more 'traditional' way on how westerners view the Mediterranean. This common approach is often recognized when, for example, we speak of 'Mediterranean diet', or, 'Mediterranean Temperament'. It would include Eastern countries like Greece and Cyprus. This article focuses on these two approaches to Mediterranean ethics after discussing issues pertaining to the region which are important to define in this context. It then analyses the need for having a Mediterranean approach to bioethical issues.

Mission and surface infrastructure concepts

NASA Technical Reports Server (NTRS)

Butler, J.; Mcdaniel, S. G.

1986-01-01

Several types of manned Mars surface missions, including sorties, fixed-base, and hybrid missions, which can be envisioned as potentially desirable approaches to the exploration and utilization of Mars are identified and discussed. Some of the advantages and disadvantages of each type are discussed briefly. Also, some of the implications of the types of missions on the surface elements' design are discussed briefly. Typical sets of surface elements are identified for each type of mission, and weights are provided for each element and set.

Tank-automotive robotics

NASA Astrophysics Data System (ADS)

Lane, Gerald R.

1999-07-01

To provide an overview of Tank-Automotive Robotics. The briefing will contain program overviews & inter-relationships and technology challenges of TARDEC managed unmanned and robotic ground vehicle programs. Specific emphasis will focus on technology developments/approaches to achieve semi- autonomous operation and inherent chassis mobility features. Programs to be discussed include: DemoIII Experimental Unmanned Vehicle (XUV), Tactical Mobile Robotics (TMR), Intelligent Mobility, Commanders Driver Testbed, Collision Avoidance, International Ground Robotics Competition (ICGRC). Specifically, the paper will discuss unique exterior/outdoor challenges facing the IGRC competing teams and the synergy created between the IGRC and ongoing DoD semi-autonomous Unmanned Ground Vehicle and DoT Intelligent Transportation System programs. Sensor and chassis approaches to meet the IGRC challenges and obstacles will be shown and discussed. Shortfalls in performance to meet the IGRC challenges will be identified.

Evaluating the Safety of New Vaccines: Summary of a Workshop

PubMed Central

Ellenberg, Susan S.; Foulkes, Mary A.; Midthun, Karen; Goldenthal, Karen L.

2005-01-01

Public concerns about the safety of vaccines arise on a regular basis. In November 2000, a workshop titled “Evaluation of New Vaccines: How Much Safety Data?” was convened by US Public Health Service agencies, including the Food and Drug Administration, the National Institutes of Health, the Centers for Disease Control and Prevention, and the Health Resources and Services Administration, to discuss appropriate methods for evaluating the safety of new vaccines. Workshop presentations addressed the current standards and approaches for new vaccine evaluation and postlicensure surveillance, as well as public views about vaccine safety and alternative approaches that could be considered. The advantages and disadvantages of conducting large controlled trials before licensure or widespread use of a new vaccine were discussed. We summarize these presentations and discussions. PMID:15855455

Playing to Learn: An Overview of the Montessori Approach with Pre-School Children with Autism Spectrum Condition

ERIC Educational Resources Information Center

Marks, Laura

2016-01-01

This article explores some of the literature concerning the effectiveness of the Montessori educational approach for children with ASC within an English school context. Firstly, there is a discussion, including a short historical review, regarding the ideology of inclusion and how it has impacted upon mainstream education. Also, how this can be…

Three Approaches to Teaching Art Methods Courses: Child Art, Visual Culture, and Issues-Based Art Education

ERIC Educational Resources Information Center

Chang, EunJung; Lim, Maria; Kim, Minam

2012-01-01

In this article, three art educators reflect on their ideas and experiences in developing and implementing innovative projects for their courses focusing on art for elementary education majors. They explore three different approaches. The three areas that are discussed in depth include: (1) understanding child art; (2) visual culture; and (3)…

Un structuralisme de bonne compagnie: Lucien Tesniere et son heritage (A Structuralism in Good Company: Lucien Tesniere and His Heritage).

ERIC Educational Resources Information Center

Kupferman, Lucien

1998-01-01

The proceedings of a 1992 French conference on the structuralist approach of linguist Lucien Tesniere are reviewed, focusing on the recent evolution of this approach in French linguistics. Topics discussed include the origins of Tesniere's theory, his model of dependency, flat phrastic structure, fusion of the lexico-semantic and lexico-syntactic…

The analysis of the pilot's cognitive and decision processes

NASA Technical Reports Server (NTRS)

Curry, R. E.

1975-01-01

Articles are presented on pilot performance in zero-visibility precision approach, failure detection by pilots during automatic landing, experiments in pilot decision-making during simulated low visibility approaches, a multinomial maximum likelihood program, and a random search algorithm for laboratory computers. Other topics discussed include detection of system failures in multi-axis tasks and changes in pilot workload during an instrument landing.

Le langage ecrit: Actes du 6e colloque d'orthophonie/logopedie (Written Language: Proceedings of the Sixth Colloquium on Speech Therapy/Speech Pathology) (Neuchatel, Switzerland, September 21-22, 2000).

ERIC Educational Resources Information Center

de Weck, Genevieve, Ed.; Sovilla, Jocelyne Buttet, Ed.

This collection of papers discusses various theoretical, clinical, and assessment issues in reading and writing delays and disorders. Topics include the following: integrating different theoretical approaches (cognitive psychology, neuropsychology, constructivism) into clinical approaches to reading and writing difficulties; difficulties of…

Literature--News That Stays News: Fresh Approaches to the Classics. Classroom Practices in Teaching English, 1984.

ERIC Educational Resources Information Center

National Council of Teachers of English, Urbana, IL.

New approaches to the teaching of the classics are explored in this collection of articles written by high school, junior college, college, and university literature instructors. The seven articles in the first section of the book discuss linking the classics. Specific topics covered in the articles include using the works of William Golding as a…

ConfChem Conference on Select 2016 BCCE Presentations: Putting Your Own Personal Twist on a Flipped Organic Classroom and Selling the Idea to Students

ERIC Educational Resources Information Center

Thomas, Ashleigh L. P.

2017-01-01

This paper presents gradual implementation of active learning approaches in an organic chemistry classroom based on student feedback and strategies for getting students on-board with this new approach. Active learning techniques discussed include videos, online quizzes, reading assignments, and classroom activities. Preliminary findings indicate a…

Ethics Instruction in Undergraduate Astronomy and Physics

NASA Astrophysics Data System (ADS)

Pilachowski, Catherine A.; van Zee, L.; Bacher, A. D.; Durisen, R. H.

2009-01-01

Instruction in research ethics is now included as part of the formal undergraduate curriculum in astronomy and physics at Indiana University. Traditionally, students learn research ethics through informal mentoring by research advisors. However, a more formal approach is encouraged by funding agencies, professional societies, and common sense. Following the booklet, "On Being a Scientist: Responsible Conduct in Research" (1995, National Academy Press), our ethics program is built around a "case study" approach using scenarios involving real life situations that students are likely to encounter as undergraduates or beginning graduate students. Students discuss possible resolutions of the ethical questions involved. Discussion topics include reporting data, data rights, credit for ideas, and professional behavior. Scenarios for graduate students involve ethical concerns more appropriate for their career stage, including conflicts of interest, authorship, and collaboration. The answers are not clear-cut, and students must grapple with shades of gray to help them define what the limits of ethical behavior are. The scenarios are available on the Web at www.astro.indiana.edu/education/ethics.html

Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules.

PubMed

Dave, Vivek S; Gupta, Deepak; Yu, Monica; Nguyen, Phuong; Varghese Gupta, Sheeba

2017-02-01

The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability across the biological membranes. While these compounds are pharmacologically effective, poor absorption due to low permeability becomes the rate-limiting step in achieving adequate bioavailability. Several approaches have been explored and utilized for improving the permeability profiles of these compounds. The approaches include traditional methods such as prodrugs, permeation enhancers, ion-pairing, etc., as well as relatively modern approaches such as nanoencapsulation and nanosizing. The most recent approaches include a combination/hybridization of one or more traditional approaches to improve drug permeability. While some of these approaches have been extremely successful, i.e. drug products utilizing the approach have progressed through the USFDA approval for marketing; others require further investigation to be applicable. This article discusses the commonly studied approaches for improving the permeability of BCS Class III compounds.

Improving reliability of aggregation, numerical simulation and analysis of complex systems by empirical data

NASA Astrophysics Data System (ADS)

Dobronets, Boris S.; Popova, Olga A.

2018-05-01

The paper considers a new approach of regression modeling that uses aggregated data presented in the form of density functions. Approaches to Improving the reliability of aggregation of empirical data are considered: improving accuracy and estimating errors. We discuss the procedures of data aggregation as a preprocessing stage for subsequent to regression modeling. An important feature of study is demonstration of the way how represent the aggregated data. It is proposed to use piecewise polynomial models, including spline aggregate functions. We show that the proposed approach to data aggregation can be interpreted as the frequency distribution. To study its properties density function concept is used. Various types of mathematical models of data aggregation are discussed. For the construction of regression models, it is proposed to use data representation procedures based on piecewise polynomial models. New approaches to modeling functional dependencies based on spline aggregations are proposed.

The challenge of risk characterization: current practice and future directions.

PubMed Central

Gray, G M; Cohen, J T; Graham, J D

1993-01-01

Risk characterization is perhaps the most important part of risk assessment. As currently practiced, risk characterizations do not convey the degree of uncertainty in a risk estimate to risk managers, Congress, the press, and the public. Here, we use a framework put forth by an ad hoc study group of industry and government scientists and academics to critique the risk characterizations contained in two risks assessments of gasoline vapor. After discussing the strengths and weaknesses of each assessment's risk characterization, we detail an alternative approach that conveys estimates in the form of a probability distribution. The distributional approach can make use of all relevant scientific data and knowledge, including alternative data sets and all plausible mechanistic theories of carcinogenesis. As a result, this approach facilitates better public health decisions than current risk characterization procedures. We discuss methodological issues, as well as strengths and weaknesses of the distributional approach. PMID:8020444

From Network Analysis to Functional Metabolic Modeling of the Human Gut Microbiota.

PubMed

Bauer, Eugen; Thiele, Ines

2018-01-01

An important hallmark of the human gut microbiota is its species diversity and complexity. Various diseases have been associated with a decreased diversity leading to reduced metabolic functionalities. Common approaches to investigate the human microbiota include high-throughput sequencing with subsequent correlative analyses. However, to understand the ecology of the human gut microbiota and consequently design novel treatments for diseases, it is important to represent the different interactions between microbes with their associated metabolites. Computational systems biology approaches can give further mechanistic insights by constructing data- or knowledge-driven networks that represent microbe interactions. In this minireview, we will discuss current approaches in systems biology to analyze the human gut microbiota, with a particular focus on constraint-based modeling. We will discuss various community modeling techniques with their advantages and differences, as well as their application to predict the metabolic mechanisms of intestinal microbial communities. Finally, we will discuss future perspectives and current challenges of simulating realistic and comprehensive models of the human gut microbiota.

Research Methods in Health, Physical Education, and Recreation. Third Revised Edition.

ERIC Educational Resources Information Center

Hubbard, Alfred W., Ed.

This book presents new ideas and approaches in research techniques in the areas of health, physical education, and recreation. Part 1, the introduction, includes two articles, which are "Why This Research?" by Arthur H. Steinhaus and "Overview of Research: Basic Principles" by Benjamin H. Massey. Part 2, discusses preparations and includes the…

Short-Term Group Psychotherapy: A Clinical Trial of a New Combination of Pretreatment and Treatment Strategies.

ERIC Educational Resources Information Center

Merkel, William T.; Willis, Stephen L.

1985-01-01

The paper discusses a clinical trial of pretreatment and treatment strategies to enhance the effectiveness of short-term groups. Pretreatment strategies included preparing patients and increasing the perceived authority of the therapists. Treatment strategies include delineation of a specific treatment focus and a directive approach by the…

Strengthening Out-of-School Time Nonprofits. The Role of Foundations in Building Organizational Capacity

ERIC Educational Resources Information Center

Weiss, Heather B.; Little, Priscilla M. D.

2008-01-01

Heather B. Weiss and Priscilla D. Little of the Harvard Family Research Project suggest seven possible approaches to strengthening OST (Out-of-School) organizations, including methods to ensure that OST providers become stronger partners with other groups and more adept advocates for their field. Strategies discussed include: (1) Cultivate…

The Earth's Core: How Does It Work? Perspectives in Science. Number 1.

ERIC Educational Resources Information Center

Carnegie Institution of Washington, Washington, DC.

Various research studies designed to enhance knowledge about the earth's core are discussed. Areas addressed include: (1) the discovery of the earth's core; (2) experimental approaches used in studying the earth's core (including shock-wave experiments and experiments at high static pressures), the search for the core's light elements, the…

76 FR 23825 - Study Methodologies for Diagnostics in the Postmarket Setting; Public Workshop

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-28

... community on issues related to the studies and methodological approaches examining diagnostics in the... discuss a large number of methodological concerns at the workshop, including, but not limited to the...

Counseling the Gifted, Creative, and Talented. An Arts Activities Approach.

ERIC Educational Resources Information Center

Kenny, Adele

1987-01-01

The role of music and dance in counseling gifted students is discussed. Included are a rationale and description for both music and dance therapy as well as suggested activities and bibliographies. (DB)

Microwave Landing System signal requirements for conventional aircraft

DOT National Transportation Integrated Search

1972-07-01

The results of analysis directed towards determining Microwave Landing System (MLS) signal requirements for conventional aircraft are discussed. The phases of flight considered include straight-in final approach, flareout, and rollout. A limited numb...

A WATERSHED APPROACH TO DRINKING WATER QUALITY

EPA Science Inventory

The purpose of this presentation is to describe emerging technologies and strategies managing watersheds with the goal of protecting drinking water sources. Included are discussions on decentralized wastewater treatment, whole organism biomonitor detection systems, treatment of...

Software Review. Macintosh Laboratory Automation: Three Software Packages.

ERIC Educational Resources Information Center

Jezl, Barbara Ann

1990-01-01

Reviewed are "LABTECH NOTEBOOK,""LabVIEW," and "Parameter Manager pmPLUS/pmTALK." Each package is described including functions, uses, hardware, and costs. Advantages and disadvantages of this type of laboratory approach are discussed. (CW)

Ion- and dust-acoustic instabilities in dusty plasmas

NASA Technical Reports Server (NTRS)

Rosenberg, M.

1993-01-01

Dust ion-acoustic and dust-acoustic instabilities in dusty plasmas are investigated using a standard Vlasov approach. Possible applications of these instabilities to various cosmic environments, including protostellar clouds and planetary rings, are briefly discussed.

China: A sleeping giant awakens to environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ni Shaoxiang

1995-07-01

This article discusses the approach the Chinese government is taking to environmental issues. Included are the following topics: pollution abatement; improved rural environment by curbing the production and use of highly toxic pesticides; limiting erosion; natural reserves. Problems awaiting solutions are also discussed: air pollution (particularly coal combustion); water pollution; solid-waste pollution; rural pollution; soil erosion; desertification; soil salinization; deforestation; grassland deterioration; natural disasters.

Computational Thinking for All: Pedagogical Approaches to Embedding 21st Century Problem Solving in K-12 Classrooms

ERIC Educational Resources Information Center

Yadav, Aman; Hong, Hai; Stephenson, Chris

2016-01-01

The recent focus on computational thinking as a key 21st century skill for all students has led to a number of curriculum initiatives to embed it in K-12 classrooms. In this paper, we discuss the key computational thinking constructs, including algorithms, abstraction, and automation. We further discuss how these ideas are related to current…

A Strategy for Incorporating Learning Analytics into the Design and Evaluation of a K-12 Science Curriculum

ERIC Educational Resources Information Center

Monroy, Carlos; Rangel, Virginia Snodgrass; Whitaker, Reid

2014-01-01

In this paper, we discuss a scalable approach for integrating learning analytics into an online K-12 science curriculum. A description of the curriculum and the underlying pedagogical framework is followed by a discussion of the challenges to be tackled as part of this integration. We include examples of data visualization based on teacher usage…

PSYCHOANALYSIS AND THE ARTS: THE SLIPPERY GROUND OF APPLIED ANALYSIS.

PubMed

Abella, Adela

2016-01-01

The ways in which today's psychoanalysts approach art closely follow the avenues opened by Freud a hundred years ago. Drawing mainly on Freud's studies on Jensen's Gradiva (1907) and on Leonardo da Vinci (1910a), the author examines the main paradigms he used in discussing artistic activity, including his doubts and hesitations. Present-day approaches to art are then examined via a discussion of the advantages and pitfalls of psychobiography, of the case study, and of textual approaches. The author makes a case for the type of interdisciplinary dialogue in which the goal is to establish a cross-fertilization between psychoanalysis and other fields of knowledge while striving to avoid hypersaturation of a work of art in order to foster expansion of the mind. © 2016 The Psychoanalytic Quarterly, Inc.

Somatic Treatments for Mood Disorders

PubMed Central

Rosa, Moacyr A; Lisanby, Sarah H

2012-01-01

Somatic treatments for mood disorders represent a class of interventions available either as a stand-alone option, or in combination with psychopharmacology and/or psychotherapy. Here, we review the currently available techniques, including those already in clinical use and those still under research. Techniques are grouped into the following categories: (1) seizure therapies, including electroconvulsive therapy and magnetic seizure therapy, (2) noninvasive techniques, including repetitive transcranial magnetic stimulation, transcranial direct current stimulation, and cranial electric stimulation, (3) surgical approaches, including vagus nerve stimulation, epidural electrical stimulation, and deep brain stimulation, and (4) technologies on the horizon. Additionally, we discuss novel approaches to the optimization of each treatment, and new techniques that are under active investigation. PMID:21976043

Chemokine receptor antagonists: part 2.

PubMed

Pease, James E; Horuk, Richard

2009-02-01

The first part of this two-part review discussed approaches to generating antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and CCR4. This second part of the series concludes the review by describing antagonists for CCR5, CCR8, CCR9, CXCR3, CXCR4, and promiscuous antagonists. Chemokine receptor antagonists have found mixed success as therapeutics. Although one antagonist--maraviroc, a CCR5 inhibitor to treat AIDS--has been registered as an approved drug, this is the only success so far. There have been many failures in the clinic and we discuss the idea of promiscuous receptor antagonists as an alternative approach.

Ethical issues in caring for patients with dementia.

PubMed

Hughes, Julian; Common, Jill

2015-08-05

This article discusses issues that might count as 'ethical' in the care of people with dementia and some of the dilemmas that occur. Ethical theories, such as virtue ethics, deontology and consequentialism are discussed, and ethical approaches that can be useful are outlined. Thinking about matters case-by-case is another approach, one that forms the first component of the Nuffield Council's ethical framework for dementia care, which is described. Case examples are provided, raising issues of autonomy, diagnosis, restraint and withholding treatment. The notion of personhood and the need to understand the person with dementia as broadly as possible are emphasised. Recommendations for nursing practice are included.

Ab initio quantum chemistry: methodology and applications.

PubMed

Friesner, Richard A

2005-05-10

This Perspective provides an overview of state-of-the-art ab initio quantum chemical methodology and applications. The methods that are discussed include coupled cluster theory, localized second-order Moller-Plesset perturbation theory, multireference perturbation approaches, and density functional theory. The accuracy of each approach for key chemical properties is summarized, and the computational performance is analyzed, emphasizing significant advances in algorithms and implementation over the past decade. Incorporation of a condensed-phase environment by means of mixed quantum mechanical/molecular mechanics or self-consistent reaction field techniques, is presented. A wide range of illustrative applications, focusing on materials science and biology, are discussed briefly.

Novel application of bacteriophage for controlling foaming in wastewater treatment plant- an eco-friendly approach

PubMed Central

Khairnar, Krishna; Chandekar, Rajshree; Nair, Aparna; Pal, Preeti; Paunikar, Waman N.

2016-01-01

ABSTRACT This addendum to “Novel application of bacteriophage for controlling foaming in wastewater treatment plant- an eco-friendly approach “ includes characteristics of the phages NOC1, NOC2 and NOC3 not discussed in the previous paper. The phage adsorption and host interaction properties, their sensitivity to pH and temperature are inferred. NOC2 is seen to be more temperature resistant while others are not. All the phages show pH sensitivity. There is a variance observed in the behavior of these phages. Also, applicability of the phage based system to large scale reactors is studied and discussed here. PMID:26890996

Novel application of bacteriophage for controlling foaming in wastewater treatment plant- an eco-friendly approach.

PubMed

Khairnar, Krishna; Chandekar, Rajshree; Nair, Aparna; Pal, Preeti; Paunikar, Waman N

2016-01-01

This addendum to "Novel application of bacteriophage for controlling foaming in wastewater treatment plant- an eco-friendly approach " includes characteristics of the phages NOC1, NOC2 and NOC3 not discussed in the previous paper. The phage adsorption and host interaction properties, their sensitivity to pH and temperature are inferred. NOC2 is seen to be more temperature resistant while others are not. All the phages show pH sensitivity. There is a variance observed in the behavior of these phages. Also, applicability of the phage based system to large scale reactors is studied and discussed here.

A system approach to archival storage

NASA Technical Reports Server (NTRS)

Corcoran, John W.

1991-01-01

The introduction and viewgraphs of a discussion on a system approach to archival storage presented at the National Space Science Data Center (NSSDC) Mass Storage Workshop is included. The use of D-2 iron particles for archival storage is discussed along with how acceleration factors relating short-term tests to archival life times can be justified. Ampex Recording Systems is transferring D-2 video technology to data storage applications, and encountering concerns about corrosion. To protect the D-2 standard, Battelle tests were done on all four tapes in the Class 2 environment. Error rates were measured before and after the test on both exposed and control groups.

Pediatric Status Epilepticus Management

PubMed Central

Abend, Nicholas S; Loddenkemper, Tobias

2014-01-01

Purpose of Review This review discusses management of status epilepticus in children including both anticonvulsant medications and overall management approaches. Recent Findings Rapid management of status epilepticus is associated with a greater likelihood of seizure termination and better outcomes, yet data indicate there are often management delays. This review discusses an overall management approach aiming to simultaneously identify and manage underlying precipitant etiologies, administer anticonvulsants in rapid succession until seizures have terminated, and identify and manage systemic complications. An example management pathway is provided. Summary Status epilepticus is a common neurologic emergency in children and requires rapid intervention. Having a predetermined status epilepticus management pathway can expedite management. PMID:25304961

Composite scores in comparative effectiveness research: counterbalancing parsimony and dimensionality in patient-reported outcomes.

PubMed

Schwartz, Carolyn E; Patrick, Donald L

2014-07-01

When planning a comparative effectiveness study comparing disease-modifying treatments, competing demands influence choice of outcomes. Current practice emphasizes parsimony, although understanding multidimensional treatment impact can help to personalize medical decision-making. We discuss both sides of this 'tug of war'. We discuss the assumptions, advantages and drawbacks of composite scores and multidimensional outcomes. We describe possible solutions to the multiple comparison problem, including conceptual hierarchy distinctions, statistical approaches, 'real-world' benchmarks of effectiveness and subgroup analysis. We conclude that comparative effectiveness research should consider multiple outcome dimensions and compare different approaches that fit the individual context of study objectives.

Marine geodesy a multipurpose approach to solve oceanic problems. [including submersible navigation under iced seas, demarcation and determination of boundaries in deep ocean, tsunamis, and ecology

NASA Technical Reports Server (NTRS)

Saxena, N.

1974-01-01

Various current and future problem areas of marine geodesy are identified. These oceanic problem areas are highly diversified and include submersible navigation under ice seas, demarcation and determination of boundaries in deep ocean, tsunamis, ecology, etc., etc. Their achieved as well as desired positional accuracy estimates, based upon publications and discussions, are also given. A multipurpose approach to solve these problems is described. An optimum configuration of an ocean-bottom control-net unit is provided.

Analysing photonic structures in plants

PubMed Central

Vignolini, Silvia; Moyroud, Edwige; Glover, Beverley J.; Steiner, Ullrich

2013-01-01

The outer layers of a range of plant tissues, including flower petals, leaves and fruits, exhibit an intriguing variation of microscopic structures. Some of these structures include ordered periodic multilayers and diffraction gratings that give rise to interesting optical appearances. The colour arising from such structures is generally brighter than pigment-based colour. Here, we describe the main types of photonic structures found in plants and discuss the experimental approaches that can be used to analyse them. These experimental approaches allow identification of the physical mechanisms producing structural colours with a high degree of confidence. PMID:23883949

Learning the Relationship between Galaxy Spectra and Star Formation Histories

NASA Astrophysics Data System (ADS)

Lovell, Christopher; Acquaviva, Viviana; Iyer, Kartheik; Gawiser, Eric

2018-01-01

We explore novel approaches to the problem of predicting a galaxy’s star formation history (SFH) from its Spectral Energy Distribution (SED). Traditional approaches to SED template fitting use constant or exponentially declining SFHs, and are known to incur significant bias in the inferred SFHs, which are typically skewed toward younger stellar populations. Machine learning approaches, including tree ensemble methods and convolutional neural networks, would not be affected by the same bias, and may work well in recovering unbiased and multi-episodic star formation histories. We use a supervised approach whereby models are trained using synthetic spectra, generated from three state of the art hydrodynamical simulations, including nebular emission. We explore how SED feature maps can be used to highlight areas of the spectrum with the highest predictive power and discuss the limitations of the approach when applied to real data.

Hypersonic Materials and Structures

NASA Technical Reports Server (NTRS)

Glass, David E.

2016-01-01

Thermal protection systems (TPS) and hot structures are required for a range of hypersonic vehicles ranging from ballistic reentry to hypersonic cruise vehicles, both within Earth's atmosphere and non-Earth atmospheres. The focus of this presentation is on air breathing hypersonic vehicles in the Earth's atmosphere. This includes single-stage to orbit (SSTO), two-stage to orbit (TSTO) accelerators, access to space vehicles, and hypersonic cruise vehicles. This paper will start out with a brief discussion of aerodynamic heating and thermal management techniques to address the high heating, followed by an overview of TPS for rocket-launched and air-breathing vehicles. The argument is presented that as we move from rocket-based vehicles to air-breathing vehicles, we need to move away from the insulated airplane approach used on the Space Shuttle Orbiter to a wide range of TPS and hot structure approaches. The primary portion of the paper will discuss issues and design options for CMC TPS and hot structure components, including leading edges, acreage TPS, and control surfaces. The current state-of-the-art will be briefly discussed for some of the components.

Angiogenic therapy for cardiac repair based on protein delivery systems.

PubMed

Formiga, F R; Tamayo, E; Simón-Yarza, T; Pelacho, B; Prósper, F; Blanco-Prieto, M J

2012-05-01

Cardiovascular diseases remain the first cause of morbidity and mortality in the developed countries and are a major problem not only in the western nations but also in developing countries. Current standard approaches for treating patients with ischemic heart disease include angioplasty or bypass surgery. However, a large number of patients cannot be treated using these procedures. Novel curative approaches under investigation include gene, cell, and protein therapy. This review focuses on potential growth factors for cardiac repair. The role of these growth factors in the angiogenic process and the therapeutic implications are reviewed. Issues including aspects of growth factor delivery are presented in relation to protein stability, dosage, routes, and safety matters. Finally, different approaches for controlled growth factor delivery are discussed as novel protein delivery platforms for cardiac regeneration.

Dust: a metric for use in residential and building exposure assessment and source characterization.

PubMed Central

Lioy, Paul J; Freeman, Natalie C G; Millette, James R

2002-01-01

In this review, we examine house dust and residential soil and their use for identifying sources and the quantifying levels of toxicants for the estimation of exposure. We answer critical questions that focus on the selection of samples or sampling strategies for collection and discuss areas of uncertainty and gaps in knowledge. We discuss the evolution of dust sampling with a special emphasis on work conducted after the publication of the 1992 review by McArthur [Appl Occup Environ Hyg 7(9):599-606 (1992)]. The approaches to sampling dust examined include surface wipe sampling, vacuum sampling, and other sampling approaches, including attic sampling. The metrics of presentation of results for toxicants in dust surface loading (micrograms per square centimeter) or surface concentration (micrograms per gram) are discussed. We evaluate these metrics in terms of how the information can be used in source characterization and in exposure characterization. We discuss the types of companion information on source use and household or personal activity patterns required to assess the significance of the dust exposure. The status and needs for wipe samplers, surface samplers, and vacuum samplers are summarized with some discussion on the strengths and weaknesses of each type of sampler. We also discuss needs for research and development and the current status of standardization. Case studies are provided to illustrate the use of house dust and residential soil in source characterization, forensic analyses, or human exposure assessment. PMID:12361921

Dust: a metric for use in residential and building exposure assessment and source characterization.

PubMed

Lioy, Paul J; Freeman, Natalie C G; Millette, James R

2002-10-01

In this review, we examine house dust and residential soil and their use for identifying sources and the quantifying levels of toxicants for the estimation of exposure. We answer critical questions that focus on the selection of samples or sampling strategies for collection and discuss areas of uncertainty and gaps in knowledge. We discuss the evolution of dust sampling with a special emphasis on work conducted after the publication of the 1992 review by McArthur [Appl Occup Environ Hyg 7(9):599-606 (1992)]. The approaches to sampling dust examined include surface wipe sampling, vacuum sampling, and other sampling approaches, including attic sampling. The metrics of presentation of results for toxicants in dust surface loading (micrograms per square centimeter) or surface concentration (micrograms per gram) are discussed. We evaluate these metrics in terms of how the information can be used in source characterization and in exposure characterization. We discuss the types of companion information on source use and household or personal activity patterns required to assess the significance of the dust exposure. The status and needs for wipe samplers, surface samplers, and vacuum samplers are summarized with some discussion on the strengths and weaknesses of each type of sampler. We also discuss needs for research and development and the current status of standardization. Case studies are provided to illustrate the use of house dust and residential soil in source characterization, forensic analyses, or human exposure assessment.

Synthesizing evidence on complex interventions: how meta-analytical, qualitative, and mixed-method approaches can contribute.

PubMed

Petticrew, Mark; Rehfuess, Eva; Noyes, Jane; Higgins, Julian P T; Mayhew, Alain; Pantoja, Tomas; Shemilt, Ian; Sowden, Amanda

2013-11-01

Although there is increasing interest in the evaluation of complex interventions, there is little guidance on how evidence from complex interventions may be reviewed and synthesized, and the relevance of the plethora of evidence synthesis methods to complexity is unclear. This article aims to explore how different meta-analytical approaches can be used to examine aspects of complexity; describe the contribution of various narrative, tabular, and graphical approaches to synthesis; and give an overview of the potential choice of selected qualitative and mixed-method evidence synthesis approaches. The methodological discussions presented here build on a 2-day workshop held in Montebello, Canada, in January 2012, involving methodological experts from the Campbell and Cochrane Collaborations and from other international review centers (Anderson L, Petticrew M, Chandler J, et al. systematic reviews of complex interventions. In press). These systematic review methodologists discussed the broad range of existing methods and considered the relevance of these methods to reviews of complex interventions. The evidence from primary studies of complex interventions may be qualitative or quantitative. There is a wide range of methodological options for reviewing and presenting this evidence. Specific contributions of statistical approaches include the use of meta-analysis, meta-regression, and Bayesian methods, whereas narrative summary approaches provide valuable precursors or alternatives to these. Qualitative and mixed-method approaches include thematic synthesis, framework synthesis, and realist synthesis. A suitable combination of these approaches allows synthesis of evidence for understanding complex interventions. Reviewers need to consider which aspects of complex interventions should be a focus of their review and what types of quantitative and/or qualitative studies they will be including, and this will inform their choice of review methods. These may range from standard meta-analysis through to more complex mixed-method synthesis and synthesis approaches that incorporate theory and/or user's perspectives. Copyright © 2013 Elsevier Inc. All rights reserved.

Evaluer la competence de communication (Evaluating Communicative Competence).

ERIC Educational Resources Information Center

Hediard, Marie

1988-01-01

The structure of a course designed to teach oral communicative competence is outlined, and the approach to evaluation is discussed. Evaluation includes both a criterion test and a specific oral task that students must accomplish. (MSE)

Social, Economic, and Political Change: Portents for Reform in Engineering Curricula.

ERIC Educational Resources Information Center

Wenk, Edward, Jr.

1988-01-01

Discusses the needs and properties of human systems including issues of safety and the holistic approach in engineering. Lists a suggested introductory engineering curriculum. Describes characteristics of future realities in managing technology. (YP)

Ocean tides and quasi-stationary departures from the marine geoid investigation

NASA Technical Reports Server (NTRS)

Siry, J. W.; Kahn, W. D.; Bryan, J. W.; Vonbun, F. O.

1973-01-01

The detection of tides and/or currents through the analysis of data generated in connection with the Ocean Geoid Determination Investigation is presented. A discussion of the detailed objectives and approach are included.

Painful Shoulder in Swimmers: A Diagnostic Challenge.

ERIC Educational Resources Information Center

McMaster, William C.

1986-01-01

This article discusses the incidence, diagnosis, and treatment of painful shoulder in swimmers, including: regional problems that can cause shoulder pain; physical, clinical, and laboratory tests for diagnostic use; and approaches to management of the problem. (Author/CB)

Educational Challenges in Toxicology.

ERIC Educational Resources Information Center

Dixon, Robert L.

1984-01-01

Issues and topics related to educational challenges in toxicology at all levels are discussed. They include public awareness and understanding, general approach to toxicology, quality structure-activity relationships, epidemiological studies, quantification of risk, and the types of toxicants studied. (JN)

Approaches to Addressing Environmental Challenges with Wind Energy in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sinclair, Karin C

This presentation gives an overview of U.S. wind energy development's impacts on wildlife - particularly birds and bats. It includes discussion of mitigation efforts, research collaboratives, and U.S. Department of Energy funding.

Multiple Approaches to Design Education

ERIC Educational Resources Information Center

Fox, Richard L.; And Others

1974-01-01

Discusses implementation of Sloan Foundation projects at the Case Western School of Engineering, including the development of a computer assisted mechanical structural design course, the establishment of a complex systems laboratory, and personnel views of industry-university design projects. (CC)

Assessment of the U. S. Marine Transportation System : a report to congress

DOT National Transportation Integrated Search

1999-09-01

Discusses the collaborative effort to assess the adequacy of the Nation's marine : transportation system (including ports, waterways, harbor approach channels, and : their intermodal connections) to operate in a safe, efficient, secure, and : environ...

Positioning challenges in reconfigurable semi-autonomous robotic NDE inspection

NASA Astrophysics Data System (ADS)

Pierce, S. Gareth; Dobie, Gordon; Summan, Rahul; Mackenzie, Liam; Hensman, James; Worden, Keith; Hayward, Gordon

2010-03-01

This paper describes work conducted into mobile, wireless, semi-autonomous NDE inspection robots developed at The University of Strathclyde as part of the UK Research Centre for Non Destructive Evaluation (RCNDE). The inspection vehicles can incorporate a number of different NDE payloads including ultrasonic, eddy current, visual and magnetic based payloads, and have been developed to try and improve NDE inspection techniques in challenging inspection areas (for example oil, gas, and nuclear structures). A significant research challenge remains in the accurate positioning and guidance of such vehicles for real inspection tasks. Employing both relative and absolute position measurements, we discuss a number of approaches to position estimation including Kalman and particle filtering. Using probabilistic approaches enables a common mathematical framework to be employed for both positioning and data fusion from different NDE sensors. In this fashion the uncertainties in both position and defect identification and classification can be dealt with using a consistent approach. A number of practical constraints and considerations to different precision positioning techniques are discussed, along with NDE applications and the potential for improved inspection capabilities by utilising the inherent reconfigurable capabilities of the inspection vehicles.

Tracheal bioengineering: the next steps. Proceeds of an International Society of Cell Therapy Pulmonary Cellular Therapy Signature Series Workshop, Paris, France, April 22, 2014.

PubMed

Weiss, Daniel J; Elliott, Martin; Jang, Queenie; Poole, Brian; Birchall, Martin

2014-12-01

There has been significant and exciting recent progress in the development of bioengineering approaches for generating tracheal tissue that can be used for congenital and acquired tracheal diseases. This includes a growing clinical experience in both pediatric and adult patients with life-threatening tracheal diseases. However, not all of these attempts have been successful, and there is ongoing discussion and debate about the optimal approaches to be used. These include considerations of optimal materials, particularly use of synthetic versus biologic scaffolds, appropriate cellularization of the scaffolds, optimal surgical approaches and optimal measure of both clinical and biologic outcomes. To address these issues, the International Society of Cell Therapy convened a first-ever meeting of the leading clinicians and tracheal biologists, along with experts in regulatory and ethical affairs, to discuss and debate the issues. A series of recommendations are presented for how to best move the field ahead. Copyright © 2014 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Getting the lead out: understanding risks in the distribution ...

EPA Pesticide Factsheets

This presentation discusses the importance of the water distribution system as a component of the source-to-tap continuum in public health protection. Issues covered include: understanding source water quality changes and their impacts throughout the system; use of mitigation measures such as filters); and holistic approaches and/or strategies that could be used to avoid unintended consequences of decisions from source to tap. Invited presentation on topics indicated as of interest. With exposure to lead as the context, this presentation discusses the importance of the water distribution system as a component of the source-to-tap continuum in public health protection. Issues covered include: understanding source water quality changes and their impacts throughout the system; use of mitigation measures such as filters); and holistic approaches and/or strategies that could be used to avoid unintended consequences of decisions from source to tap.

Advanced Insider Threat Mitigation Workshop Instructional Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibbs, Philip; Larsen, Robert; O'Brien, Mike

Insiders represent a formidable threat to nuclear facilities. This set of workshop materials covers methodologies to analyze and approaches to mitigate the threat of an insider attempting abrupt and protracted theft of nuclear materials. This particular set of materials is an update of a January 2008 version to add increased emphasis on Material Control and Accounting and its role with respect to protracted insider nuclear material theft scenarios. This report is a compilation of workshop materials consisting of lectures on technical and administrative measures used in Physical Protection (PP) and Material Control and Accounting (MC&A) and methods for analyzing theirmore » effectiveness against a postulated insider threat. The postulated threat includes both abrupt and protracted theft scenarios. Presentation is envisioned to be through classroom instruction and discussion. Several practical and group exercises are included for demonstration and application of the analysis approach contained in the lecture/discussion sessions as applied to a hypothetical nuclear facility.« less

Management of weight loss in obesity-associated male infertility: a spotlight on bariatric surgery.

PubMed

Abiad, Firass; Awwad, Johnny; Abbas, Hussein A; Zebian, Dina; Ghazeeri, Ghina

2017-12-01

In recent years, there has been a paralleled increase between male obesity and infertility rates. Obesity is associated with impaired hypothalamic-pituitary-gonadal axis, aberrant semen parameters, and subfertility or infertility. Weight loss is strongly recommended for the management of obesity-associated infertility. Lifestyle modifications that include caloric restriction and increased physical activity have a short-lived impact. Bariatric surgery is a better and more durable weight loss alternative. Comprehensive information about the benefits of weight loss on obesity-associated male infertility following bariatric surgery is still emerging. In this review, we discuss the hormonal, physical and environmental mechanism contributing to obesity-associated infertility. We then assess weight loss approaches, which include lifestyle modification, medical and surgical approaches, that can improve fertility in obese men. This review focuses also on bariatric surgery for the management of obese men seeking fertility treatment. Anecdotal evidence suggesting that bariatric surgery can impair fertility is also discussed.

Identifying Mother-Child Interaction Styles Using a Person-Centered Approach.

PubMed

Nelson, Jackie A; O'Brien, Marion; Grimm, Kevin J; Leerkes, Esther M

2014-05-01

Parent-child conflict in the context of a supportive relationship has been discussed as a potentially constructive interaction pattern; the current study is the first to test this using a holistic analytic approach. Interaction styles, defined as mother-child conflict in the context of maternal sensitivity, were identified and described with demographic and stress-related characteristics of families. Longitudinal associations were tested between interaction styles and children's later social competence. Participants included 814 partnered mothers with a first-grade child. Latent profile analysis identified agreeable , dynamic , and disconnected interaction styles. Mothers' intimacy with a partner, depressive symptoms, and authoritarian childrearing beliefs, along with children's later conflict with a best friend and externalizing problems, were associated with group membership. Notably, the dynamic style, characterized by high sensitivity and high conflict, included families who experienced psychological and relational stressors. Findings are discussed with regard to how family stressors shape parent-child interaction patterns.

Identifying Mother-Child Interaction Styles Using a Person-Centered Approach

PubMed Central

Nelson, Jackie A.; O’Brien, Marion; Grimm, Kevin J.; Leerkes, Esther M.

2016-01-01

Parent-child conflict in the context of a supportive relationship has been discussed as a potentially constructive interaction pattern; the current study is the first to test this using a holistic analytic approach. Interaction styles, defined as mother-child conflict in the context of maternal sensitivity, were identified and described with demographic and stress-related characteristics of families. Longitudinal associations were tested between interaction styles and children’s later social competence. Participants included 814 partnered mothers with a first-grade child. Latent profile analysis identified agreeable, dynamic, and disconnected interaction styles. Mothers’ intimacy with a partner, depressive symptoms, and authoritarian childrearing beliefs, along with children’s later conflict with a best friend and externalizing problems, were associated with group membership. Notably, the dynamic style, characterized by high sensitivity and high conflict, included families who experienced psychological and relational stressors. Findings are discussed with regard to how family stressors shape parent-child interaction patterns. PMID:28751818

Performance characterization of material identification systems

NASA Astrophysics Data System (ADS)

Brown, Christopher D.; Green, Robert L.

2006-10-01

In recent years a number of analytical devices have been proposed and marketed specifically to enable field-based material identification. Technologies reliant on mass, near- and mid-infrared, and Raman spectroscopies are available today, and other platforms are imminent. These systems tend to perform material recognition based on an on-board library of material signatures. While figures of merit for traditional quantitative analytical sensors are broadly established (e.g., SNR, selectivity, sensitivity, limit of detection/decision), measures of performance for material identification systems have not been systematically discussed. In this paper we present an approach to performance characterization similar in spirit to ROC curves, but including elements of precision-recall curves and specialized for the intended-use of material identification systems. Important experimental considerations are discussed, including study design, sources of bias, uncertainty estimation, and cross-validation and the approach as a whole is illustrated using a commercially available handheld Raman material identification system.

Nanoelectronics from the bottom up.

PubMed

Lu, Wei; Lieber, Charles M

2007-11-01

Electronics obtained through the bottom-up approach of molecular-level control of material composition and structure may lead to devices and fabrication strategies not possible with top-down methods. This review presents a brief summary of bottom-up and hybrid bottom-up/top-down strategies for nanoelectronics with an emphasis on memories based on the crossbar motif. First, we will discuss representative electromechanical and resistance-change memory devices based on carbon nanotube and core-shell nanowire structures, respectively. These device structures show robust switching, promising performance metrics and the potential for terabit-scale density. Second, we will review architectures being developed for circuit-level integration, hybrid crossbar/CMOS circuits and array-based systems, including experimental demonstrations of key concepts such lithography-independent, chemically coded stochastic demultipluxers. Finally, bottom-up fabrication approaches, including the opportunity for assembly of three-dimensional, vertically integrated multifunctional circuits, will be critically discussed.

Solar Heating And Cooling Of Buildings (SHACOB): Requirements definition and impact analysis-2. Volume 2: Domestic hot water systems

NASA Astrophysics Data System (ADS)

Cretcher, C. K.

1980-11-01

The various types of solar domestic hot water systems are discussed including their advantages and disadvantages. The problems that occur in hydronic solar heating systems are reviewed with emphasis on domestic hot water applicatons. System problems in retrofitting of residential buildings are also discussed including structural and space constraints for various components and subsystems. System design parameters include various collector sizing methods, collector orientation, storage capacity and heat loss from pipes and tanks. The installation costs are broken down by components and subsystems. The approach used for utility economic impact analysis is reviewed. The simulation is described, and the results of the economic impact analysis are given. A summary assessment is included.

Data communication between data terminal equipment and the JPL administrative data base management system

NASA Technical Reports Server (NTRS)

Iverson, R. W.

1984-01-01

Approaches to enabling an installed base of mixed data terminal equipment to access a data base management system designed to work with a specific terminal are discussed. The approach taken by the Jet Propulsion Laboratory is described. Background information on the Jet Propulsion Laboratory (JPL), its organization and a description of the Administrative Data Base Management System is included.

Making Invisible Latino Adolescents Visible: A Critical Approach to Latino Diversity. Michigan State University Series on Children, Youth, and Families, Volume 7.

ERIC Educational Resources Information Center

Montero-Sieburth, Martha, Ed.; Villarruel, Francisco A., Ed.

The papers in this collection explore a variety of economic and social issues facing Latino adolescents, including those of Latino diversity or unity, sexuality, and family values. The authors discuss ways to respond to these issues, suggesting approaches that can contribute to the healthy development of Latino adolescents. The chapters are: (1)…

Towards Intelligent Control for Next Generation CESTOL Aircraft

NASA Technical Reports Server (NTRS)

Acosta, Diana Michelle

2008-01-01

This talk will present the motivation, research approach and status of intelligent control research for Next Generation Cruise Efficient Short Take Off and Landing (CESTOL) aircraft. An introduction to the challenges of CESTOL control will be given, leading into an assessment of potential control solutions. The approach of the control research will be discussed, including a brief overview of the technical aspects of the research.

Approach to hypoglycemia in infants and children

PubMed Central

2017-01-01

Hypoglycemia is a heterogeneous disorder with many different possible etiologies, including hyperinsulinism, glycogen storage disorders, fatty acid disorders, hormonal deficiencies, and metabolic defects, among others. This condition affects newborns to adolescents, with various approaches to diagnosis and management. This paper will review current literature on the history of hypoglycemia, current discussion on the definition of hypoglycemia, as well as etiologies, diagnosis, and management. PMID:29184821

Developing Distinct Mathematical and Scientific Pedagogical Content Knowledge in an Early Childhood Dual-Content Methods Course: An Alternative to Integration

ERIC Educational Resources Information Center

Kalchman, Mindy; Kozoll, Richard H.

2017-01-01

Methods for teaching early childhood mathematics and science are often addressed in a single, dual-content course. Approaches to teaching this type of course include integrating the content and the pedagogy of both subjects, or keeping the subject areas distinct. In this article, the authors discuss and illustrate their approach to such a combined…

Symposium on General Linear Model Approach to the Analysis of Experimental Data in Educational Research (Athens, Georgia, June 29-July 1, 1967). Final Report.

ERIC Educational Resources Information Center

Bashaw, W. L., Ed.; Findley, Warren G., Ed.

This volume contains the five major addresses and subsequent discussion from the Symposium on the General Linear Models Approach to the Analysis of Experimental Data in Educational Research, which was held in 1967 in Athens, Georgia. The symposium was designed to produce systematic information, including new methodology, for dissemination to the…

Single Component Sorption-Desorption Test Experimental Design Approach Discussions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phil WInston

A task was identified within the fission-product-transport work package to develop a path forward for doing testing to determine behavior of volatile fission products behavior and to engage members of the NGNP community to advise and dissent on the approach. The following document is a summary of the discussions and the specific approaches suggested for components of the testing. Included in the summary isare the minutes of the conference call that was held with INL and external interested parties to elicit comments on the approaches brought forward by the INL participants. The conclusion was that an initial non-radioactive, single componentmore » test will be useful to establish the limits of currently available chemical detection methods, and to evaluated source-dispersion uniformity. In parallel, development of a real-time low-concentration monitoring method is believed to be useful in detecting rapid dispersion as well as desorption phenomena. Ultimately, the test cycle is expected to progress to the use of radio-traced species, simply because this method will allow the lowest possible detection limits. The consensus of the conference call was that there is no need for an in-core test because the duct and heat exchanger surfaces that will be the sorption target will be outside the main neutron flux and will not be affected by irradiation. Participants in the discussion and contributors to the INL approach were Jeffrey Berg, Pattrick Calderoni, Gary Groenewold, Paul Humrickhouse, Brad Merrill, and Phil Winston. Participants from outside the INL included David Hanson of General Atomics, Todd Allen, Tyler Gerczak, and Izabela Szlufarska of the University of Wisconsin, Gary Was, of the University of Michigan, Sudarshan Loyalka and Tushar Ghosh of the University of Missouri, and Robert Morris of Oak Ridge National Laboratory.« less

Refining search terms for nanotechnology

NASA Astrophysics Data System (ADS)

Porter, Alan L.; Youtie, Jan; Shapira, Philip; Schoeneck, David J.

2008-05-01

The ability to delineate the boundaries of an emerging technology is central to obtaining an understanding of the technology's research paths and commercialization prospects. Nowhere is this more relevant than in the case of nanotechnology (hereafter identified as "nano") given its current rapid growth and multidisciplinary nature. (Under the rubric of nanotechnology, we also include nanoscience and nanoengineering.) Past efforts have utilized several strategies, including simple term search for the prefix nano, complex lexical and citation-based approaches, and bootstrapping techniques. This research introduces a modularized Boolean approach to defining nanotechnology which has been applied to several research and patenting databases. We explain our approach to downloading and cleaning data, and report initial results. Comparisons of this approach with other nanotechnology search formulations are presented. Implications for search strategy development and profiling of the nanotechnology field are discussed.

Some thoughts on the management of large, complex international space ventures

NASA Technical Reports Server (NTRS)

Lee, T. J.; Kutzer, Ants; Schneider, W. C.

1992-01-01

Management issues relevant to the development and deployment of large international space ventures are discussed with particular attention given to previous experience. Management approaches utilized in the past are labeled as either simple or complex, and signs of efficient management are examined. Simple approaches include those in which experiments and subsystems are developed for integration into spacecraft, and the Apollo-Soyuz Test Project is given as an example of a simple multinational approach. Complex approaches include those for ESA's Spacelab Project and the Space Station Freedom in which functional interfaces cross agency and political boundaries. It is concluded that individual elements of space programs should be managed by individual participating agencies, and overall configuration control is coordinated by level with a program director acting to manage overall objectives and project interfaces.

Pharmaceutical approaches to preparing pelletized dosage forms using the extrusion-spheronization process.

PubMed

Trivedi, Namrata R; Rajan, Maria Gerald; Johnson, James R; Shukla, Atul J

2007-01-01

Pelletized dosage forms date back to the 1950s, when the first product was introduced to the market. Since then, these dosage forms have gained considerable popularity because of their distinct advantages, such as ease of capsule filling because of better flow properties of the spherical pellets; enhancement of drug dissolution; ease of coating; sustained, controlled, or site-specific delivery of the drug from coated pellets; uniform packing; even distribution in the GI tract; and less GI irritation. Pelletized dosage forms can be prepared by a number of techniques, including drug layering on nonpareil sugar or microcrystalline cellulose beads, spray drying, spray congealing, rotogranulation, hot-melt extrusion, and spheronization of low melting materials or extrusion-spheronization of a wet mass. This review discusses recent developments in the pharmaceutical approaches that have been used to prepare pelletized dosage forms using the extrusion-spheronization process over the last decade. The review is divided into three parts: the first part discusses the extrusion-spheronization process, the second part discusses the effect of varying formulation and process parameters on the properties of the pellets, and the last part discusses the different approaches that have been used to prepare pelletized dosage forms using the extrusion-spheronization process.

Patient and Practice Perspectives on Strategies for Controlling Blood Pressure, North Carolina, 2010–2012

PubMed Central

Vu, Maihan B.; Halladay, Jacqueline R.; Miller, Cassandra; Garcia, Beverly A.; Cummings, Doyle M.; Cene, Crystal W.; Hinderliter, Alan; Little, Edwin; Rachide, Marjorie; DeWalt, Darren

2014-01-01

Introduction Patient and practice perspectives can inform development of team-based approaches to improving blood pressure control in primary care. We used a community-based participatory research approach to assess patient and practice perceptions regarding the value of team-based strategies for controlling blood pressure in a rural North Carolina population from 2010 through 2012. Methods In-depth interviews were conducted with 41 adults with hypertension, purposely sampled to include diversity of sex, race, literacy, and blood pressure control, and with key office staff at 5 rural primary care practices in the southeastern US “stroke belt.” Interviews explored barriers to controlling blood pressure, the practice’s role in controlling blood pressure, and opinions on the use of team care delivery. Results Patients reported that provider strategies to optimize blood pressure control should include regular visits, medication adjustment, side-effect discussion, and behavioral counseling. When discussing team-based approaches to hypertension care, patients valued verbal encouragement, calls from the doctor’s office, and the opportunity to ask questions. However, they voiced concerns about the effect of having too many people involved in their care. Practice staff focused on multiple, broad methods to control blood pressure including counseling, regular office visits, media to improve awareness, and support groups. An explicit focus of delivering care as teams was a newer concept. Conclusion When developing a team approach to hypertension treatment, patients value high-quality communication and not losing their primary relationship with their provider. Practice staff members were open to a team-based approach but had limited knowledge of what such an approach would entail. PMID:24762533

Application of tire dynamics to aircraft landing gear design analysis

NASA Technical Reports Server (NTRS)

Black, R. J.

1983-01-01

The tire plays a key part in many analyses used for design of aircraft landing gear. Examples include structural design of wheels, landing gear shimmy, brake whirl, chatter and squeal, complex combination of chatter and shimmy on main landing gear (MLG) systems, anti-skid performance, gear walk, and rough terrain loads and performance. Tire parameters needed in the various analyses are discussed. Two tire models are discussed for shimmy analysis, the modified Moreland approach and the von Schlippe-Dietrich approach. It is shown that the Moreland model can be derived from the Von Schlippe-Dietrich model by certain approximations. The remaining analysis areas are discussed in general terms and the tire parameters needed for each are identified. Accurate tire data allows more accurate design analysis and the correct prediction of dynamic performance of aircraft landing gear.

Information Wants To Be Shared: An Alternative Framework for Approaching Intellectual Property Disputes in an Information Age.

ERIC Educational Resources Information Center

Tavani, Herman T.

2002-01-01

Discusses the debate over intellectual property rights for digital media. Topics include why intellectual property should be protected; the evolution of copyright law; fair use doctrine; case studies; the philosophical theories of property, including labor theory, utilitarian theory, and personality theory; natural law theory; the social role of…

Powder compaction in systems of bimodal distribution

NASA Technical Reports Server (NTRS)

Chattopadhyay, A. K.; Whittemore, O. J., Jr.

1973-01-01

The compaction of mixtures involving different particle sizes is discussed. The various stages of the compaction process include the rearrangement of particles, the filling of the interstices of the large particles by the smaller ones, and the change in particle size and shape upon further densification through the application of pressure. Experimental approaches and equipment used for compacting material are discussed together with the theoretical relations of the compacting process.

Ceramic Matrix Composite (CMC) Thermal Protection Systems (TPS) and Hot Structures for Hypersonic Vehicles

NASA Technical Reports Server (NTRS)

Glass, David E.

2008-01-01

Thermal protection systems (TPS) and hot structures are required for a range of hypersonic vehicles ranging from ballistic reentry to hypersonic cruise vehicles, both within Earth's atmosphere and non-Earth atmospheres. The focus of this paper is on air breathing hypersonic vehicles in the Earth's atmosphere. This includes single-stage to orbit (SSTO), two-stage to orbit (TSTO) accelerators, access to space vehicles, and hypersonic cruise vehicles. This paper will start out with a brief discussion of aerodynamic heating and thermal management techniques to address the high heating, followed by an overview of TPS for rocket-launched and air-breathing vehicles. The argument is presented that as we move from rocket-based vehicles to air-breathing vehicles, we need to move away from the insulated airplane approach used on the Space Shuttle Orbiter to a wide range of TPS and hot structure approaches. The primary portion of the paper will discuss issues and design options for CMC TPS and hot structure components, including leading edges, acreage TPS, and control surfaces. The current state-of-the-art will be briefly discussed for some of the components. The two primary technical challenges impacting the use of CMC TPS and hot structures for hypersonic vehicles are environmental durability and fabrication, and will be discussed briefly.

Adolescent RSA Responses during an Anger Discussion Task: Relations to Emotion Regulation and Adjustment

PubMed Central

Cui, Lixian; Morris, Amanda Sheffield; Harrist, Amanda W.; Larzelere, Robert E.; Criss, Michael M.; Houltberg, Benjamin J.

2015-01-01

The current study examined associations between adolescent respiratory sinus arrhythmia (RSA) during an angry event discussion task and adolescents’ emotion regulation and adjustment. Data were collected from 206 adolescents (10–18 years old, M age = 13.37). Electrocardiogram (ECG) and respiration data were collected from adolescents, and RSA values and respiration rates were computed. Adolescents reported on their own emotion regulation, prosocial behavior, and aggressive behavior. Multi-level latent growth modeling was employed to capture RSA responses across time (i.e., linear and quadratic changes; time course approach), and adolescent emotion regulation and adjustment variables were included in the model to test their links to RSA responses. Results indicated that high RSA baseline was associated with more adolescent prosocial behavior. A pattern of initial RSA decreases (RSA suppression) in response to angry event recall and subsequent RSA increases (RSA rebound) were related to better anger and sadness regulation and more prosocial behavior. However, RSA was not significantly linked to adolescent aggressive behavior. We also compared the time course approach with the conventional linear approach and found that the time course approach provided more meaningful and rich information. The implications of adaptive RSA change patterns are discussed. PMID:25642723

Functional disorders of the anus and rectum

PubMed Central

Whitehead, W; Wald, A; Diamant, N; Enck, P; Pemberton, J; Rao, S

1999-01-01

In this report the functional anorectal disorders, the etiology of which is currently unknown or related to the abnormal functioning of normally innervated and structurally intact muscles, are discussed. These disorders include functional fecal incontinence, functional anorectal pain, including levator ani syndrome and proctalgia fugax, and pelvic floor dyssynergia. The epidemiology of each disorder is defined and discussed, their pathophysiology is summarized and diagnostic approaches and treatment are suggested. Some suggestions for the direction of future research on these disorders are also given.


Keywords: fecal incontinence; pelvic floor dyssynergia; anismus; proctalgia fugax; levator ani syndrome; constipation; Rome II PMID:10457046

Activity recognition using Video Event Segmentation with Text (VEST)

NASA Astrophysics Data System (ADS)

Holloway, Hillary; Jones, Eric K.; Kaluzniacki, Andrew; Blasch, Erik; Tierno, Jorge

2014-06-01

Multi-Intelligence (multi-INT) data includes video, text, and signals that require analysis by operators. Analysis methods include information fusion approaches such as filtering, correlation, and association. In this paper, we discuss the Video Event Segmentation with Text (VEST) method, which provides event boundaries of an activity to compile related message and video clips for future interest. VEST infers meaningful activities by clustering multiple streams of time-sequenced multi-INT intelligence data and derived fusion products. We discuss exemplar results that segment raw full-motion video (FMV) data by using extracted commentary message timestamps, FMV metadata, and user-defined queries.

The design of radiation-hardened ICs for space - A compendium of approaches

NASA Technical Reports Server (NTRS)

Kerns, Sherra E.; Shafer, B. D; Rockett, L. R., Jr.; Pridmore, J. S.; Berndt, D. F.

1988-01-01

Several technologies, including bulk and epi CMOS, CMOS/SOI-SOS (silicon-on-insulator-silicon-on-sapphire), CML (current-mode logic), ECL (emitter-coupled logic), analog bipolar (JI, single-poly DI, and SOI) and GaAs E/D (enhancement/depletion) heterojunction MESFET, are discussed. The discussion includes the direct effects of space radiation on microelectronic materials and devices, how these effects are evidenced in circuit and device design parameter variations, the particular effects of most significance to each functional class of circuit, specific techniques for hardening high-speed circuits, design examples for integrated systems, including operational amplifiers and A/D (analog/digital) converters, and the computer simulation of radiation effects on microelectronic ISs.

Beyond the androgen receptor II: New approaches to understanding and treating metastatic prostate cancer; Report from the 2017 Coffey-Holden Prostate Cancer Academy Meeting.

PubMed

Miyahira, Andrea K; Cheng, Heather H; Abida, Wassim; Ellis, Leigh; Harshman, Lauren C; Spratt, Daniel E; Simons, Jonathan W; Pienta, Kenneth J; Soule, Howard R

2017-11-01

The 2017 Coffey-Holden Prostate Cancer Academy (CHPCA) Meeting, "Beyond the Androgen Receptor II: New Approaches to Understanding and Treating Metastatic Prostate Cancer," was held in Carlsbad, California from June 14-17, 2017. The CHPCA is an annual scientific conference hosted by the Prostate Cancer Foundation (PCF) that is uniquely designed to produce extensive and constructive discussions on the most urgent and impactful topics concerning research into the biology and treatment of metastatic prostate cancer. The 2017 CHPCA Meeting was the 5th meeting in this annual series and was attended by 71 investigators focused on prostate cancer and a variety of other fields including breast and ovarian cancer. The discussions at the meeting were concentrated on topics areas including: mechanisms and therapeutic approaches for molecular subclasses of castrate resistant prostate cancer (CRPC), the epigenetic landscape of prostate cancer, the role of DNA repair gene mutations, advancing the use of germline genetics in clinical practice, radionuclides for imaging and therapy, advances in molecular imaging, and therapeutic strategies for successful use of immunotherapy in advanced prostate cancer. This article reviews the presentations and discussions from the 2017 CHPCA Meeting in order to disseminate this knowledge and accelerate new biological understandings and advances in the treatment of patients with metastatic prostate cancer. © 2017 Wiley Periodicals, Inc.

Microbiological cleanliness of the Mars Exploration Rover spacecraft

NASA Technical Reports Server (NTRS)

Newlin, L.; Barengoltz, J.; Chung, S.; Kirschner, L.; Koukol, R.; Morales, F.

2002-01-01

Planetary protection for Mars missions is described, and the approach being taken by the Mars Exploration Rover Project is discussed. Specific topics include alcohol wiping, dry heat microbial reduction, microbiological assays, and the Kennedy Space center's PHSF clean room.

Research News: Debate on Learning Theory Is Shifting.

ERIC Educational Resources Information Center

Fox, Jeffrey L.

1983-01-01

Discusses current learning theories, indicating that though many psychologists and ethologists now agree on using a mechanistic approach, some linguists doubt its adequacy. Implications of research on the mollusk "Aplasia" to understand the learning process are included. (JN)

Gathering Circles: An Experience in Creativity and Variety.

ERIC Educational Resources Information Center

Nakagomi, Koji

2000-01-01

Presents materials and methods that maintain student interest and encourage them to think creatively, develop mathematical reasoning, and look at problems from different perspectives, all within an open-ended approach to problem solving. Includes questions for discussion. (KHR)

Roots of success: Marketing strategies for the 21st Century

Treesearch

Ian Doescher

2012-01-01

As the demographic of gardeners and farmers changes, retail nurseries should update their marketing approach. This paper reviews best marketing practices and discusses marketing technologies, including quick response (QR) codes, websites, online marketing, and social media.

POLLUTION CONTROL GUIDANCE FOR GEOTHERMAL ENERGY DEVELOPMENT

EPA Science Inventory

This report summarizes the EPA regulatory approach toward geothermal energy development. The state of knowledge is described with respect to the constituents of geothermal effluents and emissions, including water, air, solid wastes, and noise. Pollutant effects are discussed. Pol...

Interpretative Communities in Conflict: A Master Syllabus for Political Communication.

ERIC Educational Resources Information Center

Smith, Craig Allen

1992-01-01

Advocates the interpretive communities approach to teaching political communication. Discusses philosophical issues in the teaching of political communication courses, and pedagogical techniques (including concepts versus cases, clustering examples, C-SPAN video examples, and simulations and games). (SR)

Attributing Illness to Food

PubMed Central

Doyle, Michael P.; Morris, J. Glenn; Painter, John; Singh, Ruby; Tauxe, Robert V.; Taylor, Michael R.; Wong, Danilo M.A. Lo Fo

2005-01-01

Identification and prioritization of effective food safety interventions require an understanding of the relationship between food and pathogen from farm to consumption. Critical to this cause is food attribution, the capacity to attribute cases of foodborne disease to the food vehicle or other source responsible for illness. A wide variety of food attribution approaches and data are used around the world, including the analysis of outbreak data, case-control studies, microbial subtyping and source tracking methods, and expert judgment, among others. The Food Safety Research Consortium sponsored the Food Attribution Data Workshop in October 2003 to discuss the virtues and limitations of these approaches and to identify future options for collecting food attribution data in the United States. We summarize workshop discussions and identify challenges that affect progress in this critical component of a risk-based approach to improving food safety. PMID:16022770

Clinical skills education for graduate-entry nursing students: enhancing learning using a multimodal approach.

PubMed

Bloomfield, Jacqueline G; Cornish, Jocelyn C; Parry, Angela M; Pegram, Anne; Moore, Jaqualyn S

2013-03-01

This paper discusses the development of a new clinical skills course at a school of nursing and midwifery in London. The course, part of a two year pre-registration programme for graduates in other disciplines, adopted an innovative multimodal approach. This comprised a range of teaching, learning and assessment strategies designed to maximise comprehensiveness, complementarity and flexibility. The background to the development is discussed and each component is described in detail. A brief summary of relevant feedback generated from anonymous student evaluations is included. This provides important insights into the perceived strengths and weakness of the module from a learner perspective. The paper concludes by identifying proposed future developments and recommending wider applications of the multimodal approach within nursing and healthcare education on an international level. Copyright © 2011 Elsevier Ltd. All rights reserved.

Protecting retinal ganglion cells.

PubMed

Khatib, T Z; Martin, K R

2017-02-01

Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including pharmacological neuroprotection, mesenchymal stem cells, and gene therapy approaches. We highlight potential pitfalls that need to be considered when developing these strategies and outline future directions, including the prospects for clinical trials.

Using default methodologies to derive an acceptable daily exposure (ADE).

PubMed

Faria, Ellen C; Bercu, Joel P; Dolan, David G; Morinello, Eric J; Pecquet, Alison M; Seaman, Christopher; Sehner, Claudia; Weideman, Patricia A

2016-08-01

This manuscript discusses the different historical and more recent default approaches that have been used to derive an acceptable daily exposure (ADE). While it is preferable to derive a health-based ADE based on a complete nonclinical and clinical data package, this is not always possible. For instance, for drug candidates in early development there may be no or limited nonclinical or clinical trial data. Alternative approaches that can support decision making with less complete data packages represent a variety of methods that rely on default assumptions or data inputs where chemical-specific data on health effects are lacking. A variety of default approaches are used including those based on certain toxicity estimates, a fraction of the therapeutic dose, cleaning-based limits, the threshold of toxicological concern (TTC), and application of hazard banding tools such as occupational exposure banding (OEB). Each of these default approaches is discussed in this manuscript, including their derivation, application, strengths, and limitations. In order to ensure patient safety when faced with toxicological and clinical data-gaps, default ADE methods should be purposefully as or more protective than ADEs derived from full data packages. Reliance on the subset of default approaches (e.g., TTC or OEB) that are based on toxicological data is preferred over other methods for establishing ADEs in early development while toxicology and clinical data are still being collected. Copyright © 2016. Published by Elsevier Inc.

Physical Processes in the MAGO/MFT Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garanin, Sergey F; Reinovsky, Robert E.

2015-03-23

The Monograph is devoted to theoretical discussion of the physical effects, which are most significant for the alternative approach to the problem of controlled thermonuclear fusion (CTF): the MAGO/MTF approach. The book includes the description of the approach, its difference from the major CTF systems—magnetic confinement and inertial confinement systems. General physical methods of the processes simulation in this approach are considered, including plasma transport phenomena and radiation, and the theory of transverse collisionless shock waves, the surface discharges theory, important for such kind of research. Different flows and magneto-hydrodynamic plasma instabilities occurring in the frames of this approach aremore » also considered. In virtue of the general physical essence of the considered phenomena the presented results are applicable to a wide range of plasma physics and hydrodynamics processes. The book is intended for the plasma physics and hydrodynamics specialists, post-graduate students, and senior students-physicists.« less

Summary of the 2014 Sandia V&V Challenge Workshop

DOE PAGES

Schroeder, Benjamin B.; Hu, Kenneth T.; Mullins, Joshua Grady; ...

2016-02-19

A discussion of the five responses to the 2014 Sandia Verification and Validation (V&V) Challenge Problem, presented within this special issue, is provided hereafter. Overviews of the challenge problem workshop, workshop participants, and the problem statement are also included. Brief summations of teams' responses to the challenge problem are provided. Issues that arose throughout the responses that are deemed applicable to the general verification, validation, and uncertainty quantification (VVUQ) community are the main focal point of this paper. The discussion is oriented and organized into big picture comparison of data and model usage, VVUQ activities, and differentiating conceptual themes behindmore » the teams' VVUQ strategies. Significant differences are noted in the teams' approaches toward all VVUQ activities, and those deemed most relevant are discussed. Beyond the specific details of VVUQ implementations, thematic concepts are found to create differences among the approaches; some of the major themes are discussed. Lastly, an encapsulation of the key contributions, the lessons learned, and advice for the future are presented.« less

A review of recent developments in flight test techniques at the Ames Research Center, Dryden Flight Research Facility

NASA Technical Reports Server (NTRS)

Layton, G. P.

1984-01-01

New flight test techniques in use at Ames Dryden are reviewed. The use of the pilot in combination with ground and airborne computational capabilities to maximize data return is discussed, including the remotely piloted research vehicle technique for high-risk testing, the remotely augmented vehicle technique for handling qualities research, and use of ground computed flight director information to fly unique profiles such as constant Reynolds number profiles through the transonic flight regime. Techniques used for checkout and design verification of systems-oriented aircraft are discussed, including descriptions of the various simulations, iron bird setups, and vehicle tests. Some newly developed techniques to support the aeronautical research disciplines are discussed, including a new approach to position-error determination, and the use of a large skin friction balance for the measurement of drag caused by various excrescencies.

Analysing hierarchy in the organization of biological and physical systems.

PubMed

Jagers op Akkerhuis, Gerard A J M

2008-02-01

A structured approach is discussed for analysing hierarchy in the organization of biological and physical systems. The need for a structured approach follows from the observation that many hierarchies in the literature apply conflicting hierarchy rules and include ill-defined systems. As an alternative, we suggest a framework that is based on the following analytical steps: determination of the succession stage of the universe, identification of a specific system as part of the universe, specification of external influences on a system's creation and analysis of a system's internal organization. At the end, the paper discusses practical implications of the proposed method for the analysis of system organization and hierarchy in biology, ecology and physics.

NASA Past, Present, and Future: The Use of Commercial Off The Shelf (COTS) Electronics in Space

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.; Guertin, Steven M.

2017-01-01

NASA has a long history of using commercial grade electronics in space. In this presentation we will provide a brief history of NASA's trends and approaches to commercial grade electronics focusing on processing and memory systems. This will include providing summary information on the space hazards to electronics as well as NASA mission trade space. We will also discuss developing recommendations for risk management approaches to Electrical, Electronic and Electromechanical (EEE) parts usage in space. Two examples will be provided focusing on a near-earth Polar-orbiting spacecraft as well as a mission to Mars. The final portion will discuss emerging trends impacting usage.

Violence among young men: the importance of a gender-specific developmental approach to adolescent male suicide and homicide.

PubMed

Rice, Timothy R

2015-05-01

Suicide and homicide are much more commonly committed by adolescent males than females. Herein, a proposal in favor of gender-specific understanding and approach to these violent behaviors is presented. Social and healthcare service system factors, including issues of male adolescents' access to care and help-seeking behaviors, are reviewed alongside the epidemiology of adolescent suicide and homicide as a transition into a detailed discussion of the putative biological factors at play. An emphasis upon the male androgen testosterone organizes the discussion. Behavioral manifestations of this brain-based organizational model are presented with a focus on impulsivity, aggression, and externalizing dysregulated emotionality. Treatment considerations and implications are developed.

Mixing qualitative and quantitative research in developmental science: uses and methodological choices.

PubMed

Yoshikawa, Hirokazu; Weisner, Thomas S; Kalil, Ariel; Way, Niobe

2008-03-01

Multiple methods are vital to understanding development as a dynamic, transactional process. This article focuses on the ways in which quantitative and qualitative methodologies can be combined to enrich developmental science and the study of human development, focusing on the practical questions of "when" and "how." Research situations that may be especially suited to mixing qualitative and quantitative approaches are described. The authors also discuss potential choices for using mixed quantitative- qualitative approaches in study design, sampling, construction of measures or interview protocols, collaborations, and data analysis relevant to developmental science. Finally, they discuss some common pitfalls that occur in mixing these methods and include suggestions for surmounting them.

On discounting of health gains from human papillomavirus vaccination: effects of different approaches.

PubMed

Westra, Tjalke A; Parouty, Mehraj; Brouwer, Werner B; Beutels, Philippe H; Rogoza, Raina M; Rozenbaum, Mark H; Daemen, Toos; Wilschut, Jan C; Boersma, Cornelis; Postma, Maarten J

2012-05-01

Discounting has long been a matter of controversy in the field of health economic evaluations. How to weigh future health effects has resulted in ongoing discussions. These discussions are imminently relevant for health care interventions with current costs but future benefits. Different approaches to discount health effects have been proposed. In this study, we estimated the impact of different approaches for discounting health benefits of human papillomavirus (HPV) vaccination. An HPV model was used to estimate the impact of different discounting approaches on the present value of health effects. For the constant discount approaches, we varied the discount rate for health effects ranging from 0% to 4%. Next, the impact of relevant alternative discounting approaches was estimated, including hyperbolic, proportional, stepwise, and time-shifted discounting. The present value of health effects gained through HPV vaccination varied strongly when varying discount rates and approaches. The application of the current Dutch guidelines resulted in a present value of health effects that was eight or two times higher than that produced when using the proportional discounting approach or when using the internationally more common 4% discount rate for health effects, respectively. Obviously, such differences translate into large variations in corresponding incremental cost-effectiveness ratios. The exact discount rate and approach chosen in an economic evaluation importantly impact the projected value of health benefits of HPV vaccination. Investigating alternative discounting approaches in health-economic analysis is important, especially for vaccination programs yielding health effects far into the future. Our study underlines the relevance of ongoing discussions on how and at what rates to discount. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Achieving Lights-Out Operation of SMAP Using Ground Data System Automation

NASA Technical Reports Server (NTRS)

Sanders, Antonio

2013-01-01

The approach used in the SMAP ground data system to provide reliable, automated capabilities to conduct unattended operations has been presented. The impacts of automation on the ground data system architecture were discussed, including the three major automation patterns identified for SMAP and how these patterns address the operations use cases. The architecture and approaches used by SMAP will set the baseline for future JPL Earth Science missions.

Representation and Exchange of Knowledge as a Basis of Information Processes. Proceedings of the International Research Forum in Information Science (5th, Heidelberg, West Germany, September 5-7, 1983).

ERIC Educational Resources Information Center

Dietschmann, Hans, Ed.

This 22-paper collection addresses a variety of issues related to representation and transfer of knowledge. Individual papers include an explanation of the usefulness of general scientific models versus case-specific approaches and a discussion of different empirical approaches to the general problem of knowledge representation for information…

Clinical governance: bridging the gap between managerial and clinical approaches to quality of care

PubMed Central

Buetow, S. A.; Roland, M.

1999-01-01

Clinical governance has been introduced as a new approach to quality improvement in the UK national health service. This article maps clinical governance against a discussion of the four main approaches to measuring and improving quality of care: quality assessment, quality assurance, clinical audit, and quality improvement (including continuous quality improvement). Quality assessment underpins each approach. Whereas clinical audit has, in general, been professionally led, managers have driven quality improvement initiatives. Quality assurance approaches have been perceived to be externally driven by managers or to involve professional inspection. It is discussed how clinical governance seeks to bridge these approaches. Clinical governance allows clinicians in the UK to lead a comprehensive strategy to improve quality within provider organisations, although with an expectation of greatly increased external accountability. Clinical governance aims to bring together managerial, organisational, and clinical approaches to improving quality of care. If successful, it will define a new type of professionalism for the next century. Failure by the professions to seize the opportunity is likely to result in increasingly detailed external control of clinical activity in the UK, as has occurred in some other countries. PMID:10847876

A review of alternative approaches to healthcare resource allocation.

PubMed

Petrou, S; Wolstenholme, J

2000-07-01

The resources available for healthcare are limited compared with demand, if not need, and all healthcare systems, regardless of their financing and organisation, employ mechanisms to ration or prioritise finite healthcare resources. This paper reviews alternative approaches that can be used to allocate healthcare resources. It discusses the problems encountered when allocating healthcare resources according to free market principles. It then proceeds to discuss the advantages and disadvantages of alternative resource allocation approaches that can be applied to public health systems. These include: (i) approaches based on the concept of meeting the needs of the population to maximising its capacity to benefit from interventions; (ii) economic approaches that identify the most efficient allocation of resources with the view of maximising health benefits or other measures of social welfare; (iii) approaches that seek to ration healthcare by age; and (iv) approaches that resolve resource allocation disputes through debate and bargaining. At present, there appears to be no consensus about the relative importance of the potentially conflicting principles that can be used to guide resource allocation decisions. It is concluded that whatever shape tomorrow's health service takes, the requirement to make equitable and efficient use of finite healthcare resources will remain.

Global change - Geoengineering and space exploration

NASA Technical Reports Server (NTRS)

Jenkins, Lyle M.

1992-01-01

Geoengineering options and alternatives are proposed for mitigating the effects of global climate change and depletion of the ozone layer. Geoengineering options were discussed by the National Academy of Science Panel on the Policy Implications of Greenhouse Warming. Several of the ideas conveyed in their published report are space-based or depend on space systems for implementation. Among the geoengineering options using space that are discussed include the use of space power systems as an alternative to fossil fuels for generating electricity, the use of lunar He-3 to aid in the development of fusion energy, and the establishment of a lunar power system for solar energy conversion and electric power beaming back to earth. Other geoengineering options are discussed. They include the space-based modulation of hurricane forces and two space-based approaches in dealing with ozone layer depletion. The engineering challenges and policy implementation issues are discussed for these geongineering options.

Role of Soft Computing Approaches in HealthCare Domain: A Mini Review.

PubMed

Gambhir, Shalini; Malik, Sanjay Kumar; Kumar, Yugal

2016-12-01

In the present era, soft computing approaches play a vital role in solving the different kinds of problems and provide promising solutions. Due to popularity of soft computing approaches, these approaches have also been applied in healthcare data for effectively diagnosing the diseases and obtaining better results in comparison to traditional approaches. Soft computing approaches have the ability to adapt itself according to problem domain. Another aspect is a good balance between exploration and exploitation processes. These aspects make soft computing approaches more powerful, reliable and efficient. The above mentioned characteristics make the soft computing approaches more suitable and competent for health care data. The first objective of this review paper is to identify the various soft computing approaches which are used for diagnosing and predicting the diseases. Second objective is to identify various diseases for which these approaches are applied. Third objective is to categories the soft computing approaches for clinical support system. In literature, it is found that large number of soft computing approaches have been applied for effectively diagnosing and predicting the diseases from healthcare data. Some of these are particle swarm optimization, genetic algorithm, artificial neural network, support vector machine etc. A detailed discussion on these approaches are presented in literature section. This work summarizes various soft computing approaches used in healthcare domain in last one decade. These approaches are categorized in five different categories based on the methodology, these are classification model based system, expert system, fuzzy and neuro fuzzy system, rule based system and case based system. Lot of techniques are discussed in above mentioned categories and all discussed techniques are summarized in the form of tables also. This work also focuses on accuracy rate of soft computing technique and tabular information is provided for each category including author details, technique, disease and utility/accuracy.

The elements of design knowledge capture

NASA Technical Reports Server (NTRS)

Freeman, Michael S.

1988-01-01

This paper will present the basic constituents of a design knowledge capture effort. This will include a discussion of the types of knowledge to be captured in such an effort and the difference between design knowledge capture and more traditional knowledge base construction. These differences include both knowledge base structure and knowledge acquisition approach. The motivation for establishing a design knowledge capture effort as an integral part of major NASA programs will be outlined, along with the current NASA position on that subject. Finally the approach taken in design knowledge capture for Space Station will be contrasted with that used in the HSTDEK project.

Optoelectronic simulation of GaAs solar cells with angularly selective filters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraus, Tobias, E-mail: tobias.kraus@ise.fraunhofer.de; Höhn, Oliver; Hauser, Hubert

We discuss the influence of angularly selective filters on thin film gallium arsenide solar cells. For this reason, the detailed balance model was refined to fit our needs with respect to Auger recombination, reflection, transmission, and realistic absorption. For calculating real systems, an approach was made to include optical effects of angularly selective filters into electron-hole dynamic equations implemented in PC1D, a one dimensional solar cell calculation tool. With this approach, we find a relative V{sub oc} increase of 5% for an idealized 100 nm GaAs cell, including Auger recombination.

Challenges of Working in a Multicultural Environment.

ERIC Educational Resources Information Center

Howland, Joan S.

2001-01-01

Addresses challenges faced when working in a multicultural library setting and discusses the need for library administration to create supportive environments. Highlights include fluctuating power dynamics; merging diverse opinions and approaches; overcoming perceived lack of empathy; tokenism; accountability; and transforming challenges into…

Vygotsky's Methodological Contribution to Sociocultural Theory.

ERIC Educational Resources Information Center

Mahn, Holbrook

1999-01-01

This article introduces major contributions of educational psychologist, Lev S. Vygotsky, through examination of his dialectical methodological approach. Topics discussed include semiotic mediation, social sources of development, verbal thinking, concept formation, spontaneous and scientific concepts, the zone of proximal development, and higher…

Relating GTE and Knowledge-Based Courseware Engineering: Some Epistemological Issues.

ERIC Educational Resources Information Center

De Diana, Italo P. F.; Ladhani, Al-Noor

1998-01-01

Discusses GTE (Generic Tutoring Environment) and knowledge-based courseware engineering from an epistemological point of view and suggests some combination of the two approaches. Topics include intelligent tutoring; courseware authoring; application versus acquisition of knowledge; and domain knowledge. (LRW)

Person-Centered Transition Planning.

ERIC Educational Resources Information Center

Miner, Craig A.; Bates, Paul E.

1997-01-01

Describes a person-centered planning approach for involving students with disabilities and their families in the transition planning process. Components of person-centered planning are discussed, including development of a personal profile, identification of future lifestyle preferences, action steps and responsible parties, and necessary changes…

Technology Toolkit.

ERIC Educational Resources Information Center

Brooklyn Public Library, NY.

This reference resource identifies issues concerning technology use in library literacy programs and describes approaches that work at the Brooklyn (New York) Public Library. Section 1 discusses the learning centers at the library, including its mission, philosophy, curriculum, technology, volunteer tutors, and active learning environment. Section…

The Source of Tok Pisin Structures.

ERIC Educational Resources Information Center

Goulden, Rick J.

1989-01-01

The source of the similarities and differences produced by pidginization is a central question studied in Pidgin-Creole linguistics. Several explanatory approaches are discussed that have guided research in this area, including simplification, substratum, independent innovation, and universals. (27 references) (Author/OD)

Robotics: Using Technology to Teach New Technologies.

ERIC Educational Resources Information Center

Cohen, Karen C.; Meyer, Carol D.

1984-01-01

Discusses the development of industrial robotics training materials, considering the need for such materials, preliminary curriculum design, the Piagetian approach followed, and the uses of computer assisted instruction. A list of robotics curriculum courses (with content and audience indicated) is included. (JN)

Culinary Decision Making.

ERIC Educational Resources Information Center

Curtis, Rob

1987-01-01

Advises directors of ways to include day care workers in the decision-making process. Enumerates benefits of using staff to help focus and direct changes in the day care center and discusses possible pitfalls in implementation of a collective decision-making approach to management. (NH)

HPT in a Dot-Com World.

ERIC Educational Resources Information Center

Farrington, Jeanne

2001-01-01

Discusses how human performance technology can help new Internet companies. Highlights include major business goals; using a systems approach to look for gaps in the organization itself, personnel, behavior, performance, feedback, communication, and internal inefficiencies; compensation structures; recruiting; training; rewarding performance; and…

Prophylactic Knee Braces: Where Do They Stand?

ERIC Educational Resources Information Center

McCarthy, Paul

1988-01-01

The effectiveness of knee braces in preventing knee injuries in football is inconclusive. This article reviews research from epidemiologic, cadaver, and surrogate studies; discusses reasons for conflicting study results, including research design problems; and describes alternative approaches that have been suggested. (IAH)

Designing a New Urban Internet.

ERIC Educational Resources Information Center

Burke, Lauren

2002-01-01

Discusses Web site design and information architecture in light of principles of New Urbanism that are being applied in urban planning situations. Topics include networked electronic environment design; user-centered network design; multidisciplinary approaches; knowledge access and collaboration; and the Global Information Infrastructure…

International Education and the University.

ERIC Educational Resources Information Center

Calleja, James, Ed.

This collection of 15 essays discusses the integration of international education into higher education, focusing on the role of the United Nations Educational, Scientific, and Cultural Organization (UNESCO) and specific international education programs and activities at various institutions. Essays include: (1) "UNESCO's Approaches to…

What Is Instrumented Learning? Part 1

ERIC Educational Resources Information Center

Blake, Robert; Mouton, Jane

1972-01-01

Although article is directed specifically towards improving sales techniques through self evaluation, it discusses various autoinstructional aids that could be applied to other fields. These include self-ranking against an objectives" grid, forced and multiple choice quizzes and the sentence-completion approach. (PD)

Understanding Cost-Effectiveness of Energy Efficiency Programs: Best Practices, Technical Methods, and Emerging Issues for Policy-Makers

EPA Pesticide Factsheets

Reviews the issues and approaches involved in considering and adopting cost-effectiveness tests for energy efficiency, including discussing each perspective represented by the five standard cost-effectiveness tests and clarifying key terms.

Developments in Sampling and Analysis Instrumentation for Stationary Sources

ERIC Educational Resources Information Center

Nader, John S.

1973-01-01

Instrumentation for the measurement of pollutant emissions is considered including sample-site selection, sample transport, sample treatment, sample analysis, and data reduction, display, and interpretation. Measurement approaches discussed involve sample extraction from within the stack and electro-optical methods. (BL)

Demonstrations of Extraterrestrial Life Detection Techniques in the High School Biology Laboratory

ERIC Educational Resources Information Center

Saltinski, Ronald

1969-01-01

Discusses the experimental procedures and equipment for exobiology projects at the high school level. An interdisciplinary approach involving electronic equipment and micro-biological laboratory techniques is used. Photographs and diagrams of equipment are included. Bibliography. (LC)

A Review of Behavioral Conceptualizations and Treatments of Child Noncompliance.

ERIC Educational Resources Information Center

Houlihan, Daniel; And Others

1992-01-01

This review of behavioral conceptualizations and approaches to the treatment of child noncompliance includes discussion of behavioral definitions, methods of assessment, types of behavioral interventions, generalization of treatment effects, future research directions, and potential ethical concerns. (Author/JDD)

The Teaching of Electromagnetism at University Level

ERIC Educational Resources Information Center

Houldin, J. E.

1974-01-01

Discusses different kinds of material presentation in the teaching of electromagnetism at the university level, including three "classical" approaches and the Keller personalized proctorial system. Indicates that a general introduction to generators and motors may be useful in an electromagnetism course. (CC)

An Integrated Approach to Exploration Launch Office Requirements Development

NASA Technical Reports Server (NTRS)

Holladay, Jon B.; Langford, Gary

2006-01-01

The proposed paper will focus on the Project Management and Systems Engineering approach utilized to develop a set of both integrated and cohesive requirements for the Exploration Launch Office, within the Constellation Program. A summary of the programmatic drivers which influenced the approach along with details of the resulting implementation will be discussed as well as metrics evaluating the efficiency and accuracy of the various requirements development activities. Requirements development activities will focus on the procedures utilized to ensure that technical content was valid and mature in preparation for the Crew Launch Vehicle and Constellation System s Requirements Reviews. This discussion will begin at initial requirements development during the Exploration Systems Architecture Study and progress through formal development of the program structure. Specific emphasis will be given to development and validation of the requirements. This discussion will focus on approaches to garner the appropriate requirement owners (or customers), project infrastructure utilized to emphasize proper integration, and finally the procedure to technically mature, verify and validate the requirements. Examples of requirements being implemented on the Launch Vehicle (systems, interfaces, test & verification) will be utilized to demonstrate the various processes and also provide a top level understanding of the launch vehicle(s) performance goals. Details may also be provided on the approaches for verification, which range from typical aerospace hardware development (qualification/acceptance) through flight certification (flight test, etc.). The primary intent of this paper is to provide a demonstrated procedure for the development of a mature, effective, integrated set of requirements on a complex system, which also has the added intricacies of both heritage and new hardware development integration. Ancillary focus of the paper will include discussion of Test and Verification approaches along with top level systems/elements performance capabilities.

Synthesis and Labeling of RNA In Vitro

PubMed Central

Huang, Chao; Yu, Yi-Tao

2013-01-01

This unit discusses several methods for generating large amounts of uniformly labeled, end-labeled, and site-specifically labeled RNAs in vitro. The methods involve a number of experimental procedures, including RNA transcription, 5′ dephosphorylation and rephosphorylation, 3′ terminal nucleotide addition (via ligation), site-specific RNase H cleavage directed by 2′-O-methyl RNA-DNA chimeras, and 2-piece splint ligation. The applications of these RNA radiolabeling approaches are also discussed. PMID:23547015

Science Fare: An Illustrated Guide and Catalog of Toys, Books, and Activities for Kids.

ERIC Educational Resources Information Center

Saul, Wendy; Newman, Alan R.

This book addresses some of the methods by which science can be made accessible to children, both in school and non-school settings. It contains information on effective science education for elementary school age children, and includes a catalog of books and other materials. Topics discussed in the book include: (1) planning; (2) approaches to…

E-health: an overview of the uses of the Internet, social media, apps, and websites for mood disorders.

PubMed

Parikh, Sagar V; Huniewicz, Paulina

2015-01-01

The current article defines and surveys E-health: Internet and technology-guided interventions and tools useful for mood disorders. E-health encompasses many categories, including computerized self-help strategies, online psychotherapy, websites that provide information, social media approaches including Facebook, Internet forums for health discussions, personal blogs, and videogames. Multiple tools exist to assess and document symptoms, particularly mood charts. Although all of these approaches are popular, only online psychotherapy and videogames have actually been evaluated in studies to evaluate both validity and efficacy. The face validity of social communication strategies including social media and blogs is strong, with clear implications for stigma reduction and peer support. Informational websites continue to be primary sources of psychoeducation on mental disorders. Social media sites have widespread use by the public and a profusion of health discussions and tools, but without published research evaluation of efficacy. E-health strategies, particularly online psychotherapy and tools to document symptoms, are useful and likely effective. Social communication strategies show enormous popularity, but urgently require research evaluation for impact.

Plant leaf traits, canopy processes, and global atmospheric chemistry interactions.

NASA Astrophysics Data System (ADS)

Guenther, A. B.

2017-12-01

Plants produce and emit a diverse array of volatile metabolites into the atmosphere that participate in chemical reactions that influence distributions of air pollutants and short-lived climate forcers including organic aerosol, ozone and methane. It is now widely accepted that accurate estimates of these emissions are required as inputs for regional air quality and global climate models. Predicting these emissions is complicated by the large number of volatile organic compounds, driving variables (e.g., temperature, solar radiation, abiotic and biotic stresses) and processes operating across a range of scales. Modeling efforts to characterize emission magnitude and variations will be described along with an assessment of the observations available for parameterizing and evaluating these models including discussion of the limitations and challenges associated with existing model approaches. A new approach for simulating canopy scale organic emissions on regional to global scales will be described and compared with leaf, canopy and regional scale flux measurements. The importance of including additional compounds and processes as well as improving estimates of existing ones will also be discussed.

Demystifying the cytokine network: Mathematical models point the way.

PubMed

Morel, Penelope A; Lee, Robin E C; Faeder, James R

2017-10-01

Cytokines provide the means by which immune cells communicate with each other and with parenchymal cells. There are over one hundred cytokines and many exist in families that share receptor components and signal transduction pathways, creating complex networks. Reductionist approaches to understanding the role of specific cytokines, through the use of gene-targeted mice, have revealed further complexity in the form of redundancy and pleiotropy in cytokine function. Creating an understanding of the complex interactions between cytokines and their target cells is challenging experimentally. Mathematical and computational modeling provides a robust set of tools by which complex interactions between cytokines can be studied and analyzed, in the process creating novel insights that can be further tested experimentally. This review will discuss and provide examples of the different modeling approaches that have been used to increase our understanding of cytokine networks. This includes discussion of knowledge-based and data-driven modeling approaches and the recent advance in single-cell analysis. The use of modeling to optimize cytokine-based therapies will also be discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

Context-Aware Recommender Systems

NASA Astrophysics Data System (ADS)

Adomavicius, Gediminas; Tuzhilin, Alexander

The importance of contextual information has been recognized by researchers and practitioners in many disciplines, including e-commerce personalization, information retrieval, ubiquitous and mobile computing, data mining, marketing, and management. While a substantial amount of research has already been performed in the area of recommender systems, most existing approaches focus on recommending the most relevant items to users without taking into account any additional contextual information, such as time, location, or the company of other people (e.g., for watching movies or dining out). In this chapter we argue that relevant contextual information does matter in recommender systems and that it is important to take this information into account when providing recommendations. We discuss the general notion of context and how it can be modeled in recommender systems. Furthermore, we introduce three different algorithmic paradigms - contextual prefiltering, post-filtering, and modeling - for incorporating contextual information into the recommendation process, discuss the possibilities of combining several contextaware recommendation techniques into a single unifying approach, and provide a case study of one such combined approach. Finally, we present additional capabilities for context-aware recommenders and discuss important and promising directions for future research.

Wavepacket dynamics and the multi-configurational time-dependent Hartree approach

NASA Astrophysics Data System (ADS)

Manthe, Uwe

2017-06-01

Multi-configurational time-dependent Hartree (MCTDH) based approaches are efficient, accurate, and versatile methods for high-dimensional quantum dynamics simulations. Applications range from detailed investigations of polyatomic reaction processes in the gas phase to high-dimensional simulations studying the dynamics of condensed phase systems described by typical solid state physics model Hamiltonians. The present article presents an overview of the different areas of application and provides a comprehensive review of the underlying theory. The concepts and guiding ideas underlying the MCTDH approach and its multi-mode and multi-layer extensions are discussed in detail. The general structure of the equations of motion is highlighted. The representation of the Hamiltonian and the correlated discrete variable representation (CDVR), which provides an efficient multi-dimensional quadrature in MCTDH calculations, are discussed. Methods which facilitate the calculation of eigenstates, the evaluation of correlation functions, and the efficient representation of thermal ensembles in MCTDH calculations are described. Different schemes for the treatment of indistinguishable particles in MCTDH calculations and recent developments towards a unified multi-layer MCTDH theory for systems including bosons and fermions are discussed.

Challenges in detecting drowsiness based on driver’s behavior

NASA Astrophysics Data System (ADS)

Triyanti, V.; Iridiastadi, H.

2017-12-01

Drowsiness while driving has been a critical issue within the context of transportation safety. A number of approaches have been developed to reduce the risks of drowsy drivers. The mechanisms in detecting fatigue and sleepiness while driving has been categorized into three broad approaches, including vehicle-based, physiological-based, and behavior-based approaches. This paper will discuss recent studies in recognizing drowsy drivers based on their behaviors, particularly changes in eyes and facial characteristics. This paper will also address challenges in capturing aspects of natural expressions, driver responses, behavior, and task environment associated with sleepiness. Additionally, a number of technical aspects should be seriously considered, including correctly capturing face and eye characteristics from unwanted movements, unsuitable task environments, technological limitations, and individual differences.

Absorption of Solar Radiation by Clouds: An Overview

NASA Technical Reports Server (NTRS)

Tsay, Si-Chee; Einaudi, Franco (Technical Monitor)

2000-01-01

This talk provides an overview of the subject of absorption of solar radiation by clouds in the earth's atmosphere. The paper summarizes the available evidence which points to disagreements between theoretical and observed values of cloud absorption (and reflections). The importance of these discrepancies, particularly to remote sensing of clouds as well as to studies of cloud physics and earth radiation budgets, is emphasized. Existing cloud absorption and reflection measurements are reviewed and the persistent differences that exist between calculated and measured near-infrared cloud albedos are highlighted. Various explanations for these reflection and absorption discrepancies are discussed under two separate paths: a theoretician's approach and an experimentalist's approach. Examples for the former approach include model accuracy tests, large-droplet hypothesis, excess absorbing aerosol, enhanced water vapor continuum absorption, and effects of cloud inhomogeneity. The latter approach focuses on discussions of instrumental device, calibration, operational strategy, and signal/noise separation. A recommendation for future activities on this subject will be given.

Systematic Applications of Metabolomics in Metabolic Engineering

PubMed Central

Dromms, Robert A.; Styczynski, Mark P.

2012-01-01

The goals of metabolic engineering are well-served by the biological information provided by metabolomics: information on how the cell is currently using its biochemical resources is perhaps one of the best ways to inform strategies to engineer a cell to produce a target compound. Using the analysis of extracellular or intracellular levels of the target compound (or a few closely related molecules) to drive metabolic engineering is quite common. However, there is surprisingly little systematic use of metabolomics datasets, which simultaneously measure hundreds of metabolites rather than just a few, for that same purpose. Here, we review the most common systematic approaches to integrating metabolite data with metabolic engineering, with emphasis on existing efforts to use whole-metabolome datasets. We then review some of the most common approaches for computational modeling of cell-wide metabolism, including constraint-based models, and discuss current computational approaches that explicitly use metabolomics data. We conclude with discussion of the broader potential of computational approaches that systematically use metabolomics data to drive metabolic engineering. PMID:24957776

Study of flutter related computational procedures for minimum weight structural sizing of advanced aircraft

NASA Technical Reports Server (NTRS)

Oconnell, R. F.; Hassig, H. J.; Radovcich, N. A.

1976-01-01

Results of a study of the development of flutter modules applicable to automated structural design of advanced aircraft configurations, such as a supersonic transport, are presented. Automated structural design is restricted to automated sizing of the elements of a given structural model. It includes a flutter optimization procedure; i.e., a procedure for arriving at a structure with minimum mass for satisfying flutter constraints. Methods of solving the flutter equation and computing the generalized aerodynamic force coefficients in the repetitive analysis environment of a flutter optimization procedure are studied, and recommended approaches are presented. Five approaches to flutter optimization are explained in detail and compared. An approach to flutter optimization incorporating some of the methods discussed is presented. Problems related to flutter optimization in a realistic design environment are discussed and an integrated approach to the entire flutter task is presented. Recommendations for further investigations are made. Results of numerical evaluations, applying the five methods of flutter optimization to the same design task, are presented.

Investigating a holobiont: Microbiota perturbations and transkingdom networks.

PubMed

Greer, Renee; Dong, Xiaoxi; Morgun, Andrey; Shulzhenko, Natalia

2016-01-01

The scientific community has recently come to appreciate that, rather than existing as independent organisms, multicellular hosts and their microbiota comprise a complex evolving superorganism or metaorganism, termed a holobiont. This point of view leads to a re-evaluation of our understanding of different physiological processes and diseases. In this paper we focus on experimental and computational approaches which, when combined in one study, allowed us to dissect mechanisms (traditionally named host-microbiota interactions) regulating holobiont physiology. Specifically, we discuss several approaches for microbiota perturbation, such as use of antibiotics and germ-free animals, including advantages and potential caveats of their usage. We briefly review computational approaches to characterize the microbiota and, more importantly, methods to infer specific components of microbiota (such as microbes or their genes) affecting host functions. One such approach called transkingdom network analysis has been recently developed and applied in our study. (1) Finally, we also discuss common methods used to validate the computational predictions of host-microbiota interactions using in vitro and in vivo experimental systems.

Research ethics and the use of visual images in research with people with intellectual disability.

PubMed

Boxall, Kathy; Ralph, Sue

2009-03-01

The aim of this paper is to encourage debate about the use of creative visual approaches in intellectual disability research and discussion about Internet publication of photographs. Image-based research with people with intellectual disability is explored within the contexts of tighter ethical regulation of social research, increased interest in the use of visual methodologies, and rapid escalation in the numbers of digital images posted on the World Wide Web. Concern is raised about the possibility that tighter ethical regulation of social research, combined with the multitude of ethical issues raised by the use of image-based approaches may be discouraging the use of creative visual approaches in intellectual disability research. Inclusion in research through the use of accessible research methods is also an ethical issue, particularly in relation to those people who have hitherto been underrepresented in research. Visual approaches which have the potential to include people with profound and multiple intellectual disabilities are also discussed.

Evolution of space drones for planetary exploration: A review

NASA Astrophysics Data System (ADS)

Hassanalian, M.; Rice, D.; Abdelkefi, A.

2018-02-01

In the past decade, there has been a tendency to design and fabricate drones which can perform planetary exploration. Generally, there are various ways to study space objects, such as the application of telescopes and satellites, launching robots and rovers, and sending astronauts to the targeted solar bodies. However, due to the advantages of drones compared to other approaches in planetary exploration, ample research has been carried out by different space agencies in the world, including NASA to apply drones in other solar bodies. In this review paper, several studies which have been performed on space drones for planetary exploration are consolidated and discussed. Design and fabrication challenges of space drones, existing methods for their flight tests, different methods for deployment and planet entry, and various navigation and control approaches are reviewed and discussed elaborately. Limitations of applying space drones, proposed solutions for future space drones, and recommendations are also presented and discussed.

The content of diet and physical activity consultations with older adults in primary care.

PubMed

Bardach, Shoshana H; Schoenberg, Nancy E

2014-06-01

Despite numerous benefits of consuming a healthy diet and receiving regular physical activity, engagement in these behaviors is suboptimal. Since primary care visits are influential in promoting healthy behaviors, we sought to describe whether and how diet and physical activity are discussed during older adults' primary care visits. 115 adults aged 65 and older consented to have their routine primary care visits recorded. Audio-recorded visits were transcribed and diet and physical activity content was coded and analyzed. Diet and physical activity were discussed in the majority of visits. When these discussions occurred, they lasted an average of a minute and a half. Encouragement and broad discussion of benefits of improved diet and physical activity levels were the common type of exchange. Discussions rarely involved patient behavioral self-assessments, patient questions, or providers' recommendations. The majority of patient visits include discussion of diet and physical activity, but these discussions are often brief and rarely include recommendations. Providers may want to consider ways to expand their lifestyle behavior discussions to increase patient involvement and provide more detailed, actionable recommendations for behavior change. Additionally, given time constraints, a wider array of approaches to lifestyle counseling may be necessary. Published by Elsevier Ireland Ltd.

Approach path control for powered-lift STOL aircraft

NASA Technical Reports Server (NTRS)

Clymer, D. J.; Flora, C. C.

1973-01-01

A flight control system concept is defined for approach flightpath control of an augmentor wing (or similar) powered-lift STOL configuration. The proposed STOL control concept produces aircraft transient and steady-state control responses that are familiar to pilots of conventional jet transports, and has potential for good handling qualities ratings in all approach and landing phases. The effects of trailing-edge rate limits, real-engine dynamics, and atmospheric turbulence are considered in the study. A general discussion of STOL handling qualities problems and piloting techniques is included.

Continuum modeling of large lattice structures: Status and projections

NASA Technical Reports Server (NTRS)

Noor, Ahmed K.; Mikulas, Martin M., Jr.

1988-01-01

The status and some recent developments of continuum modeling for large repetitive lattice structures are summarized. Discussion focuses on a number of aspects including definition of an effective substitute continuum; characterization of the continuum model; and the different approaches for generating the properties of the continuum, namely, the constitutive matrix, the matrix of mass densities, and the matrix of thermal coefficients. Also, a simple approach is presented for generating the continuum properties. The approach can be used to generate analytic and/or numerical values of the continuum properties.

Protecting retinal ganglion cells

PubMed Central

Khatib, T Z; Martin, K R

2017-01-01

Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including pharmacological neuroprotection, mesenchymal stem cells, and gene therapy approaches. We highlight potential pitfalls that need to be considered when developing these strategies and outline future directions, including the prospects for clinical trials. PMID:28085136

Genetic toxicology at the crossroads-from qualitative hazard evaluation to quantitative risk assessment.

PubMed

White, Paul A; Johnson, George E

2016-05-01

Applied genetic toxicology is undergoing a transition from qualitative hazard identification to quantitative dose-response analysis and risk assessment. To facilitate this change, the Health and Environmental Sciences Institute (HESI) Genetic Toxicology Technical Committee (GTTC) sponsored a workshop held in Lancaster, UK on July 10-11, 2014. The event included invited speakers from several institutions and the contents was divided into three themes-1: Point-of-departure Metrics for Quantitative Dose-Response Analysis in Genetic Toxicology; 2: Measurement and Estimation of Exposures for Better Extrapolation to Humans and 3: The Use of Quantitative Approaches in Genetic Toxicology for human health risk assessment (HHRA). A host of pertinent issues were discussed relating to the use of in vitro and in vivo dose-response data, the development of methods for in vitro to in vivo extrapolation and approaches to use in vivo dose-response data to determine human exposure limits for regulatory evaluations and decision-making. This Special Issue, which was inspired by the workshop, contains a series of papers that collectively address topics related to the aforementioned themes. The Issue includes contributions that collectively evaluate, describe and discuss in silico, in vitro, in vivo and statistical approaches that are facilitating the shift from qualitative hazard evaluation to quantitative risk assessment. The use and application of the benchmark dose approach was a central theme in many of the workshop presentations and discussions, and the Special Issue includes several contributions that outline novel applications for the analysis and interpretation of genetic toxicity data. Although the contents of the Special Issue constitutes an important step towards the adoption of quantitative methods for regulatory assessment of genetic toxicity, formal acceptance of quantitative methods for HHRA and regulatory decision-making will require consensus regarding the relationships between genetic damage and disease, and the concomitant ability to use genetic toxicity results per se. © Her Majesty the Queen in Right of Canada 2016. Reproduced with the permission of the Minister of Health.

Teaching Introductory Oceanography through Case Studies: Project based approach for general education students

NASA Astrophysics Data System (ADS)

Farnsworth, K. L.; House, M.; Hovan, S. A.

2013-12-01

A recent workshop sponsored by SERC-On the Cutting Edge brought together science educators from a range of schools across the country to discuss new approaches in teaching oceanography. In discussing student interest in our classes, we were struck by the fact that students are drawn to emotional or controversial topics such as whale hunting and tsunami hazard and that these kinds of topics are a great vehicle for introducing more complex concepts such as wave propagation, ocean upwelling and marine chemistry. Thus, we have developed an approach to introductory oceanography that presents students with real-world issues in the ocean sciences and requires them to explore the science behind them in order to improve overall ocean science literacy among non-majors and majors at 2 and 4 year colleges. We have designed a project-based curriculum built around topics that include, but are not limited to: tsunami hazard, whale migration, ocean fertilization, ocean territorial claims, rapid climate change, the pacific trash patch, overfishing, and ocean acidification. Each case study or project consists of three weeks of class time and is structured around three elements: 1) a media analysis; 2) the role of ocean science in addressing the issue; 3) human impact/response. Content resources range from textbook readings, popular or current print news, documentary film and television, and data available on the world wide web from a range of sources. We employ a variety of formative assessments for each case study in order to monitor student access and understanding of content and include a significant component of in-class student discussion and brainstorming guided by faculty input to develop the case study. Each study culminates in summative assessments ranging from exams to student posters to presentations, depending on the class size and environment. We envision this approach for a range of classroom environments including large group face-to-face instruction as well as hybrid and fully online courses.

From problem people to addictive products: a qualitative study on rethinking gambling policy from the perspective of lived experience.

PubMed

Miller, Helen E; Thomas, Samantha L; Robinson, Priscilla

2018-04-06

Previous research has shown that government and industry discussions of gambling may focus on personal responsibility for gambling harm. In Australia, these discussions have largely excluded people with lived experience of problem gambling, including those involved in peer support and advocacy. We conducted 26 in-depth interviews with people with current or previous problem gambling on electronic gaming machines (EGMs) involved in peer support and advocacy activities, using an approach informed by Interpretive Policy Analysis and Constructivist Grounded Theory. Participants perceived that government and industry discussed gambling as safe and entertaining with a focus on personal responsibility for problem gambling. This focus on personal responsibility was perceived to increase stigma associated with problem gambling. In contrast, they described gambling as risky, addictive and harmful, with problem gambling resulting from the design of EGMs. As a result of their different perspectives, participants proposed different interventions to reduce gambling harm, including reducing accessibility and making products safer. Challenging the discourses used by governments and industry to describe gambling, using the lived experience of people with experience of gambling harm, may result in reduced stigma associated with problem gambling, and more effective public policy approaches to reducing harm.

Lab- and space-based researchers discuss plasma experiments

NASA Astrophysics Data System (ADS)

Baker, D. N.; Yamada, M.

Plasma physics provides a common language and set of approaches that tie together all scientists who study the acceleration, transport, and loss processes of the plasma state. Some years ago, researchers from the laboratory and space research communities suggested a workshop to bring together the diverse researchers in the respective fields. A series of workshops on the “Interrelationship between Plasma Experiments in the Laboratory and Space” (IPELS) was established, and the third meeting was held July 24-28, 1995, in the beautiful and historic town of Pitlochry in the Scottish Highlands.The conference reestablished the critical point that plasma physics is an important but surprisingly diversified research discipline. Meetings attendees discussed a number of new approaches to plasma research, including novel diagnostic techniques for use in space, such as active antennas and electric field sounding devices. Detailed discussions covered spacecraft-plasma environment interactions, including vehicle charging and neutral gas release; fundamental aspects of industrial application of dusty plasmas and waves in dusty plasmas; a very distinctive phase transition of coulomb crystals (from solid state to liquid state) in dusty plasmas; and terrella experiments to simulate and study chaotic transport in the ionosphere.

Thrombocytosis and thrombosis.

PubMed

Vannucchi, Alessandro M; Barbui, Tiziano

2007-01-01

The aim of this review is to discuss current diagnostic approaches to, and classification of, patients presenting with thrombocytosis, in light of novel information derived from the discovery of specific molecular abnormalities in chronic myeloproliferative disorders (CMPD), which represent the most common cause of primary thrombocytosis. The JAK2V617F and the MPLW515L/K mutations have been found in patients with essential thrombocythemia, polycythemia vera, and primary myelofibrosis, and less frequently in other myeloproliferative disorders complicated by thrombocytosis. However, neither mutation is disease specific nor is it universally present in patients with elevated platelet counts due to a CMPD; therefore, distinguishing between reactive and primary forms of thrombocytosis, as well as among the different clinical entities that constitute the CMPD, still requires a multifaceted diagnostic approach that includes as a key step the accurate evaluation of bone marrow histology. The role of elevated platelet counts in thrombosis, which represent the predominant complication of CMPD,significantly affecting prognosis and quality of life as well as, paradoxically, in the pathogenesis of the hemorrhagic manifestations, will be discussed. Established and novel potential risk factors for thrombosis, including the clinical relevance of the JAK2V617F mutation, and current management strategies for thrombocytosis are also briefly discussed.

Fuzzy-Trace Theory and False Memory: New Frontiers.

ERIC Educational Resources Information Center

Reyna, Valerie F.; Brainerd, C. J.

1998-01-01

Describes the origins of fuzzy-trace theory, including Piagetian, interference, information-processing, and judgment and decision-making influences. Discusses similarities and differences between fuzzy-trace theory and other approaches to memory falsification. Considers the theory's predictions regarding age differences in memory falsification and…

Descriptive approaches to landscape analysis

Treesearch

R. Burton Litton Jr.

1979-01-01

Descriptive landscape analyses include various procedures used to document visual/scenic resources. Historic and regional examples of landscape description represent desirable insight for contemporary professional inventory work. Routed and areal landscape inventories are discussed as basic tools. From them, qualitative and quantitative evaluations can be developed...

An Approach to the Evaluation of Hypermedia.

ERIC Educational Resources Information Center

Knussen, Christina; And Others

1991-01-01

Discusses methods that may be applied to the evaluation of hypermedia, based on six models described by Lawton. Techniques described include observation, self-report measures, interviews, automated measures, psychometric tests, checklists and criterion-based techniques, process models, Experimentally Measuring Usability (EMU), and a naturalistic…

Ludic Elicitation: Using Games for Knowledge Elicitation

ERIC Educational Resources Information Center

Cao, Yan

2014-01-01

Knowledge elicitation from human beings is important for many fields, such as decision support systems, risk communication, and customer preference studying. Traditional approaches include observations, questionnaires, structured and semi-structured interviews, and group discussions. Many publications have been studying different techniques for a…

Organisational Intelligence

ERIC Educational Resources Information Center

Yolles, Maurice

2005-01-01

Purpose: Seeks to explore the notion of organisational intelligence as a simple extension of the notion of the idea of collective intelligence. Design/methodology/approach: Discusses organisational intelligence using previous research, which includes the Purpose, Properties and Practice model of Dealtry, and the Viable Systems model. Findings: The…

Children Prenatally Exposed to Cocaine and Crack: Implications for Schools.

ERIC Educational Resources Information Center

Mullin, Jeff B.

1992-01-01

This paper considers the major consequences of prenatal exposure to cocaine, including physiological effects and characteristics of exposed infants and then goes on to discuss the education of these children, noting various behavioral approaches and the importance of assessment. (DB)

Is Special Education Certification a Guarantee of Teaching Excellence?

ERIC Educational Resources Information Center

Maple, Cathe Cross

1983-01-01

Based on experiences in Kansas, the problems discussed include: discrepancies between competency-based teacher education and current certification practices; categorical approaches to training and certification; reciprocal agreements for coursework and certification requirements; and the supply/demand of teachers. Possible solutions cited include…

Problems in Mathematics--Moving towards a Holistic Approach.

ERIC Educational Resources Information Center

Maree, J. G.

1992-01-01

Explanations for problems in mathematics are offered, and examples that may lead to a better understanding of problems in mathematics are discussed. Examples include the developmental, dyscalculia, dyspedagogia, behaviorist, medical, psychoanalytic, cultural, curricular, social, transactional, moral, and eclectic models. A case study exemplifies…

University Approaches to Software Copyright and Licensure Policies.

ERIC Educational Resources Information Center

Hawkins, Brian L.

Issues of copyright policy and software licensure at Drexel University that were developed during the introduction of a new microcomputing program are discussed. Channels for software distribution include: individual purchase of externally-produced software, distribution of internally-developed software, institutional licensure, and "read…

Do Not Pass Go.

ERIC Educational Resources Information Center

Alexander, Steve

2002-01-01

Discusses the drop-out rate from online courses in corporate training programs. Topics include better measures of electronic learning success and return on investment (ROI); a modular approach; course completion needed for certification requirements; and focusing on job performance improvement that results from electronic courses. (LRW)

The Short- and Long-Run Marginal Cost Curves: An Alternative Explanation.

ERIC Educational Resources Information Center

Boyd, Laura A.; Boyd, David W.

1994-01-01

Discusses issues related to short-run marginal cost and long-run marginal cost in economic theory. Asserts that few economics textbooks deal with important aspects of this concept. Includes four figures illustrating the approach suggested by the authors. (CFR)

OCLC in Europe.

ERIC Educational Resources Information Center

Deschamps, Christine

1998-01-01

Discusses the early days of the Online Computer Library Center (OCLC) in Europe, and developments in its usage. Highlights include negotiations between OCLC and France; retrospective conversion; reorganization and restructuring; the gradual approach to international use of OCLC; problems facing European libraries using OCLC; and benefits. (AEF)

Shuttle roll-out set for 17 September 1976

NASA Technical Reports Server (NTRS)

1976-01-01

The unveiling of the first reusable space shuttle vehicle by the National Aeronautics and Space Administration is discussed. The role of orbiter 101 as a test vehicle is stressed. Approach and landing tests, ground vibration tests, crew are among the topics included.

On the Application of Syntactic Methodologies in Automatic Text Analysis.

ERIC Educational Resources Information Center

Salton, Gerard; And Others

1990-01-01

Summarizes various linguistic approaches proposed for document analysis in information retrieval environments. Topics discussed include syntactic analysis; use of machine-readable dictionary information; knowledge base construction; the PLNLP English Grammar (PEG) system; phrase normalization; and statistical and syntactic phrase evaluation used…

A Future-Oriented, Globally Based Curriculum Model for Industrial Technology.

ERIC Educational Resources Information Center

Hacker, Michael

1982-01-01

Presents a future-oriented curriculum approach for industrial technology programs. Major global issues provide the basic structure for curriculum development. These issues include energy management, resource management, technological advancement, and international relations. Rationales for industrial technology are discussed and a curriculum…

Helping Students Master Improvisation.

ERIC Educational Resources Information Center

Hinz, Bob

1995-01-01

Defines musical improvisation as taking place when a musician's aural and technical facilities combine to create a spontaneous form of musical expression. Discusses the use of improvisation as a means of enhancing student interest and performance. Includes a six-step approach for teaching musical improvisation. (CFR)

Glue Sniffers with Special Needs.

ERIC Educational Resources Information Center

O'Connor, Denis

1987-01-01

Glue sniffing and solvent misuse have seriously affected children and teenagers throughout the United Kingdom. This article discusses glue sniffing in terms of prevalence, association with disability, physical and psychological effects, signs and symptoms, counseling for sniffers, and successful interventions including an approach using videotape…

A Description of the Hawthorn Center Early Intervention Program.

ERIC Educational Resources Information Center

Glovinsky, Ira; Keller, Jackie

An early intervention project for preschool handicapped children is described. Specific program goals (including improved functioning in social, emotional, communication, and preacademic areas) are listed, and roles of the interdisciplinary staff members are considered. Among evaluation approaches discussed are psychological measures, family…

Getting to the future through silviculture - Workshop proceedings

Treesearch

Dennis Murphy

1992-01-01

Includes 19 papers documenting presentations at the 1991 Forest Service National Silviculture Workshop. Discussions focus on the role of silviculture in New Perspectives (ecosystem management), new approaches to the practice of silviculture, and examples of successful integration of practices into multi resource management.

School Violence: Prevalence, Precursors, and Prevention.

ERIC Educational Resources Information Center

Juvonen, Jaanna

2002-01-01

Reviews types of school violence students confront, including a frequent precursor thereto: bullying. Discusses positive and negative aspects of current approach to school violence prevention such as surveillance, zero-tolerance policies, anti-bullying programs. Describes components of model school violence-prevention program. (Contains 38…

Current approaches for the assessment of in situ biodegradation.

PubMed

Bombach, Petra; Richnow, Hans H; Kästner, Matthias; Fischer, Anko

2010-04-01

Considering the high costs and technical difficulties associated with conventional remediation strategies, in situ biodegradation has become a promising approach for cleaning up contaminated aquifers. To verify if in situ biodegradation of organic contaminants is taking place at a contaminated site and to determine if these processes are efficient enough to replace conventional cleanup technologies, a comprehensive characterization of site-specific biodegradation processes is essential. In recent years, several strategies including geochemical analyses, microbial and molecular methods, tracer tests, metabolite analysis, compound-specific isotope analysis, and in situ microcosms have been developed to investigate the relevance of biodegradation processes for cleaning up contaminated aquifers. In this review, we outline current approaches for the assessment of in situ biodegradation and discuss their potential and limitations. We also discuss the benefits of research strategies combining complementary methods to gain a more comprehensive understanding of the complex hydrogeological and microbial interactions governing contaminant biodegradation in the field.

Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases.

PubMed

Keeling, Kim M; Bedwell, David M

2011-01-01

Suppression therapy is a treatment strategy for genetic diseases caused by nonsense mutations. This therapeutic approach utilizes pharmacological agents that suppress translation termination at in-frame premature termination codons (PTCs) to restore translation of a full-length, functional polypeptide. The efficiency of various classes of compounds to suppress PTCs in mammalian cells is discussed along with the current limitations of this therapy. We also elaborate on approaches to improve the efficiency of suppression that include methods to enhance the effectiveness of current suppression drugs and the design or discovery of new, more effective suppression agents. Finally, we discuss the role of nonsense-mediated mRNA decay (NMD) in limiting the effectiveness of suppression therapy, and describe tactics that may allow the efficiency of NMD to be modulated in order to enhance suppression therapy. Copyright © 2011 John Wiley & Sons, Ltd.

Multigroup Monte Carlo on GPUs: Comparison of history- and event-based algorithms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamilton, Steven P.; Slattery, Stuart R.; Evans, Thomas M.

This article presents an investigation of the performance of different multigroup Monte Carlo transport algorithms on GPUs with a discussion of both history-based and event-based approaches. Several algorithmic improvements are introduced for both approaches. By modifying the history-based algorithm that is traditionally favored in CPU-based MC codes to occasionally filter out dead particles to reduce thread divergence, performance exceeds that of either the pure history-based or event-based approaches. The impacts of several algorithmic choices are discussed, including performance studies on Kepler and Pascal generation NVIDIA GPUs for fixed source and eigenvalue calculations. Single-device performance equivalent to 20–40 CPU cores onmore » the K40 GPU and 60–80 CPU cores on the P100 GPU is achieved. Last, in addition, nearly perfect multi-device parallel weak scaling is demonstrated on more than 16,000 nodes of the Titan supercomputer.« less

WebQuests: a new instructional strategy for nursing education.

PubMed

Lahaie, Ulysses

2007-01-01

A WebQuest is a model or framework for designing effective Web-based instructional strategies featuring inquiry-oriented activities. It is an innovative approach to learning that is enhanced by the use of evolving instructional technology. WebQuests have invigorated the primary school (grades K through 12) educational sector around the globe, yet there is sparse evidence in the literature of WebQuests at the college and university levels. WebQuests are congruent with pedagogical approaches and cognitive activities commonly used in nursing education. They are simple to construct using a step-by-step approach, and nurse educators will find many related resources on the Internet to help them get started. Included in this article are a discussion of the critical attributes and main features of WebQuests, construction tips, recommended Web sites featuring essential resources, a discussion of WebQuest-related issues identified in the literature, and some suggestions for further research.

Multigroup Monte Carlo on GPUs: Comparison of history- and event-based algorithms

DOE PAGES

Hamilton, Steven P.; Slattery, Stuart R.; Evans, Thomas M.

2017-12-22

This article presents an investigation of the performance of different multigroup Monte Carlo transport algorithms on GPUs with a discussion of both history-based and event-based approaches. Several algorithmic improvements are introduced for both approaches. By modifying the history-based algorithm that is traditionally favored in CPU-based MC codes to occasionally filter out dead particles to reduce thread divergence, performance exceeds that of either the pure history-based or event-based approaches. The impacts of several algorithmic choices are discussed, including performance studies on Kepler and Pascal generation NVIDIA GPUs for fixed source and eigenvalue calculations. Single-device performance equivalent to 20–40 CPU cores onmore » the K40 GPU and 60–80 CPU cores on the P100 GPU is achieved. Last, in addition, nearly perfect multi-device parallel weak scaling is demonstrated on more than 16,000 nodes of the Titan supercomputer.« less

Protoflight photovoltaic power module system-level tests in the space power facility

NASA Technical Reports Server (NTRS)

Rivera, Juan C.; Kirch, Luke A.

1989-01-01

Work Package Four, which includes the NASA-Lewis and Rocketdyne, has selected an approach for the Space Station Freedom Photovoltaic (PV) Power Module flight certification that combines system level qualification and acceptance testing in the thermal vacuum environment: The protoflight vehicle approach. This approach maximizes ground test verification to assure system level performance and to minimize risk of on-orbit failures. The preliminary plans for system level thermal vacuum environmental testing of the protoflight PV Power Module in the NASA-Lewis Space Power Facility (SPF), are addressed. Details of the facility modifications to refurbish SPF, after 13 years of downtime, are briefly discussed. The results of an evaluation of the effectiveness of system level environmental testing in screening out incipient part and workmanship defects and unique failure modes are discussed. Preliminary test objectives, test hardware configurations, test support equipment, and operations are presented.

Soft Encapsulation of Flexible Electrical Stimulation Implant: Challenges and Innovations

PubMed Central

Debelle, Adrien; Hermans, Laura; Bosquet, Maxime; Dehaeck, Sam; Lonys, Laurent; Scheid, Benoit; Nonclercq, Antoine; Vanhoestenberghe, Anne

2016-01-01

In this document we discuss the main challenges encountered when producing flexible electrical stimulation implants, and present our approach to solving them for prototype production. We include a study of the optimization of the flexible PCB design, the selection of additive manufacturing materials for the mold, and the chemical compatibility of the different materials. Our approach was tested on a flexible gastro-stimulator as part of the ENDOGES research program. PMID:28078073

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nachtmann, O., E-mail: O.Nachtmann@thphys.uni-heidelberg.de

We review ideas on the structure of the QCD vacuum which had served as motivation for the discussion of various non-standard QCD effects in high-energy reactions in articles from 1984 to 1995. These effects include, in particular, transverse-momentum and spin correlations in the Drell–Yan process and soft photon production in hadron–hadron collisions. We discuss the relation of the approach introduced in the above-mentioned articles to the approach, developed later, using transverse-momentum-dependent parton distributions (TDMs). The latter approach is a special case of our more general one which allows for parton entanglement in high-energy reactions. We discuss signatures of parton entanglementmore » in the Drell–Yan reaction. Also for Higgs-boson production in pp collisions via gluon–gluon annihilation effects of entanglement of the two gluons are discussed and are found to be potentially important. These effects can be looked for in the current LHC experiments. In our opinion studying parton-entanglement effects in high-energy reactions is, on the one hand, very worthwhile by itself and, on the other hand, it allows to perform quantitative tests of standard factorisation assumptions. Clearly, the experimental observation of parton-entanglement effects in the Drell–Yan reaction and/or in Higgs-boson production would have a great impact on our understanding how QCD works in high-energy collisions.« less

Will genomic selection be a practical method for plant breeding?

PubMed

Nakaya, Akihiro; Isobe, Sachiko N

2012-11-01

Genomic selection or genome-wide selection (GS) has been highlighted as a new approach for marker-assisted selection (MAS) in recent years. GS is a form of MAS that selects favourable individuals based on genomic estimated breeding values. Previous studies have suggested the utility of GS, especially for capturing small-effect quantitative trait loci, but GS has not become a popular methodology in the field of plant breeding, possibly because there is insufficient information available on GS for practical use. In this review, GS is discussed from a practical breeding viewpoint. Statistical approaches employed in GS are briefly described, before the recent progress in GS studies is surveyed. GS practices in plant breeding are then reviewed before future prospects are discussed. Statistical concepts used in GS are discussed with genetic models and variance decomposition, heritability, breeding value and linear model. Recent progress in GS studies is reviewed with a focus on empirical studies. For the practice of GS in plant breeding, several specific points are discussed including linkage disequilibrium, feature of populations and genotyped markers and breeding scheme. Currently, GS is not perfect, but it is a potent, attractive and valuable approach for plant breeding. This method will be integrated into many practical breeding programmes in the near future with further advances and the maturing of its theory.

View Points of an Ecologist on Practical Environmental Ethic: Socioecology, Common-Pool Resources and Conservation.

PubMed

Castilla, Juan Carlos

2016-01-01

The paper centers on environmental practical ethic point of views according to a professional ecologist. Ecology and the science of Socio-ecology are defined. The framework of the Millennium Ecosystem Assessment initiative (MA 2003), including the use of ecosystems as the environmental unit of analysis, ecosystem services and human well-being as the center for assessment are discussed. Common-pool resources (CPR) and the allegory of the tragedy of the commons are used to illustrate main scientific and ethical environmental approaches, and above all to highlight the case of climate change, considering ″air-atmosphere″ as a CPR. The need to adopt practical personal environmental ethical positions is highlighted. Furthermore, on climate change, a discussion on the need to develop environmental and socio-ecological polycentric approaches: top-down and bottom-up, is included. An updated discussion on the concept of conservation, including main scientific and ethic points of view, is presented. Pope Francis's Encyclical, Laudato Si', is used to highlight environmental, socio-ecological and ethical aspects behind the comprehensive concept of Integral Ecology. The paper ends with a short synthesis on Earth modern unseen and astonishing environmental and socio-ecological rates of changes, and identifying the main barriers for personal environmental engagement. A call is done regarding the urgent need for socio-environmental ethic personal engagement and collective actions.

Hemorrhoids: From basic pathophysiology to clinical management

PubMed Central

Lohsiriwat, Varut

2012-01-01

This review discusses the pathophysiology, epidemiology, risk factors, classification, clinical evaluation, and current non-operative and operative treatment of hemorrhoids. Hemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions. The most common symptom of hemorrhoids is rectal bleeding associated with bowel movement. The abnormal dilatation and distortion of the vascular channel, together with destructive changes in the supporting connective tissue within the anal cushion, is a paramount finding of hemorrhoids. It appears that the dysregulation of the vascular tone and vascular hyperplasia might play an important role in hemorrhoidal development, and could be a potential target for medical treatment. In most instances, hemorrhoids are treated conservatively, using many methods such as lifestyle modification, fiber supplement, suppository-delivered anti-inflammatory drugs, and administration of venotonic drugs. Non-operative approaches include sclerotherapy and, preferably, rubber band ligation. An operation is indicated when non-operative approaches have failed or complications have occurred. Several surgical approaches for treating hemorrhoids have been introduced including hemorrhoidectomy and stapled hemorrhoidopexy, but postoperative pain is invariable. Some of the surgical treatments potentially cause appreciable morbidity such as anal stricture and incontinence. The applications and outcomes of each treatment are thoroughly discussed. PMID:22563187

Hemorrhoids: from basic pathophysiology to clinical management.

PubMed

Lohsiriwat, Varut

2012-05-07

This review discusses the pathophysiology, epidemiology, risk factors, classification, clinical evaluation, and current non-operative and operative treatment of hemorrhoids. Hemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions. The most common symptom of hemorrhoids is rectal bleeding associated with bowel movement. The abnormal dilatation and distortion of the vascular channel, together with destructive changes in the supporting connective tissue within the anal cushion, is a paramount finding of hemorrhoids. It appears that the dysregulation of the vascular tone and vascular hyperplasia might play an important role in hemorrhoidal development, and could be a potential target for medical treatment. In most instances, hemorrhoids are treated conservatively, using many methods such as lifestyle modification, fiber supplement, suppository-delivered anti-inflammatory drugs, and administration of venotonic drugs. Non-operative approaches include sclerotherapy and, preferably, rubber band ligation. An operation is indicated when non-operative approaches have failed or complications have occurred. Several surgical approaches for treating hemorrhoids have been introduced including hemorrhoidectomy and stapled hemorrhoidopexy, but postoperative pain is invariable. Some of the surgical treatments potentially cause appreciable morbidity such as anal stricture and incontinence. The applications and outcomes of each treatment are thoroughly discussed.

Orally disintegrating dosage forms and taste-masking technologies; 2010.

PubMed

Douroumis, Dennis

2011-05-01

In the last decade the development of orally disintegrating tablets (ODTs) and thin-film platforms has grown enormously in the field of pharmaceutical industry. A wide variety of new masking technologies combined with the aforementioned platforms have been developed in order to mask the taste of bitter active substances and achieve patient compliance. The commercial success and viability of such products requires the development of robust formulations with excellent palatability, disintegration times, physicochemical stability and pharmacokinetic profiles. In this review, emerging taste-masking technologies applied to solid dosage form manufacturing are summarized. The unique features and principles of taste-masking approaches used with ODT platforms are discussed, including the advantages and limitations of each technology. A brief discussion is also included on the taste masking of thin-film technologies, owing to their similar applications and requirements. This review elucidates the unique features of current commercially available or highly promising ODT and thin-film technologies, along with taste-masking approaches used in the manufacturing of oral solid dosage forms. A better understanding of these drug delivery approaches will help researchers to select the appropriate platform, or to develop innovative products with improved safety, compliance and clinical value.

IWGT report on quantitative approaches to genotoxicity risk ...

EPA Pesticide Factsheets

This is the second of two reports from the International Workshops on Genotoxicity Testing (IWGT) Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (the QWG). The first report summarized the discussions and recommendations of the QWG related to the need for quantitative dose–response analysis of genetic toxicology data, the existence and appropriate evaluation of threshold responses, and methods to analyze exposure-response relationships and derive points of departure (PoDs) from which acceptable exposure levels could be determined. This report summarizes the QWG discussions and recommendations regarding appropriate approaches to evaluate exposure-related risks of genotoxic damage, including extrapolation below identified PoDs and across test systems and species. Recommendations include the selection of appropriate genetic endpoints and target tissues, uncertainty factors and extrapolation methods to be considered, the importance and use of information on mode of action, toxicokinetics, metabolism, and exposure biomarkers when using quantitative exposure-response data to determine acceptable exposure levels in human populations or to assess the risk associated with known or anticipated exposures. The empirical relationship between genetic damage (mutation and chromosomal aberration) and cancer in animal models was also examined. It was concluded that there is a general correlation between cancer induction and mutagenic and/or clast

Broken detailed balance and non-equilibrium dynamics in living systems: a review

NASA Astrophysics Data System (ADS)

Gnesotto, F. S.; Mura, F.; Gladrow, J.; Broedersz, C. P.

2018-06-01

Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as high-fidelity transcription and translation, sensing, adaptation, biochemical patterning, and force generation. While biological systems such as motor enzymes violate detailed balance at the molecular scale, it remains unclear how non-equilibrium dynamics manifests at the mesoscale in systems that are driven through the collective activity of many motors. Indeed, in several cellular systems the presence of non-equilibrium dynamics is not always evident at large scales. For example, in the cytoskeleton or in chromosomes one can observe stationary stochastic processes that appear at first glance thermally driven. This raises the question how non-equilibrium fluctuations can be discerned from thermal noise. We discuss approaches that have recently been developed to address this question, including methods based on measuring the extent to which the system violates the fluctuation-dissipation theorem. We also review applications of this approach to reconstituted cytoskeletal networks, the cytoplasm of living cells, and cell membranes. Furthermore, we discuss a more recent approach to detect actively driven dynamics, which is based on inferring broken detailed balance. This constitutes a non-invasive method that uses time-lapse microscopy data, and can be applied to a broad range of systems in cells and tissue. We discuss the ideas underlying this method and its application to several examples including flagella, primary cilia, and cytoskeletal networks. Finally, we briefly discuss recent developments in stochastic thermodynamics and non-equilibrium statistical mechanics, which offer new perspectives to understand the physics of living systems.

Broken detailed balance and non-equilibrium dynamics in living systems: a review.

PubMed

Gnesotto, F S; Mura, F; Gladrow, J; Broedersz, C P

2018-06-01

Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as high-fidelity transcription and translation, sensing, adaptation, biochemical patterning, and force generation. While biological systems such as motor enzymes violate detailed balance at the molecular scale, it remains unclear how non-equilibrium dynamics manifests at the mesoscale in systems that are driven through the collective activity of many motors. Indeed, in several cellular systems the presence of non-equilibrium dynamics is not always evident at large scales. For example, in the cytoskeleton or in chromosomes one can observe stationary stochastic processes that appear at first glance thermally driven. This raises the question how non-equilibrium fluctuations can be discerned from thermal noise. We discuss approaches that have recently been developed to address this question, including methods based on measuring the extent to which the system violates the fluctuation-dissipation theorem. We also review applications of this approach to reconstituted cytoskeletal networks, the cytoplasm of living cells, and cell membranes. Furthermore, we discuss a more recent approach to detect actively driven dynamics, which is based on inferring broken detailed balance. This constitutes a non-invasive method that uses time-lapse microscopy data, and can be applied to a broad range of systems in cells and tissue. We discuss the ideas underlying this method and its application to several examples including flagella, primary cilia, and cytoskeletal networks. Finally, we briefly discuss recent developments in stochastic thermodynamics and non-equilibrium statistical mechanics, which offer new perspectives to understand the physics of living systems.

2016 Energetic Materials Gordon Research Conference and Gordon Research Seminar Research Area 7: Chemical Sciences 7.0 Chemical Sciences (Dr. James K. Parker)

DTIC Science & Technology

2016-08-10

thermal decomposition and mechanical damage of energetics. The program for the meeting included nine oral presentation sessions. Discussion leaders...USA) 7:30 pm - 7:35 pm Introduction by Discussion Leader 7:35 pm - 7:50 pm Vincent Baijot (Laboratory for Analysis and Architecture of Systems , CNRS...were synthesis of new materials, performance, advanced diagnostics, experimental techniques, theoretical approaches, and computational models for

Adolescent RSA responses during an anger discussion task: Relations to emotion regulation and adjustment.

PubMed

Cui, Lixian; Morris, Amanda Sheffield; Harrist, Amanda W; Larzelere, Robert E; Criss, Michael M; Houltberg, Benjamin J

2015-06-01

The current study examined associations between adolescent respiratory sinus arrhythmia (RSA) during an angry event discussion task and adolescents' emotion regulation and adjustment. Data were collected from 206 adolescents (10-18 years of age, M age = 13.37). Electrocardiogram (ECG) and respiration data were collected from adolescents, and RSA values and respiration rates were computed. Adolescents reported on their own emotion regulation, prosocial behavior, and aggressive behavior. Multilevel latent growth modeling was employed to capture RSA responses across time (i.e., linear and quadratic changes; time course approach), and adolescent emotion regulation and adjustment variables were included in the model to test their links to RSA responses. Results indicated that high RSA baseline was associated with more adolescent prosocial behavior. A pattern of initial RSA decreases (RSA suppression) in response to angry event recall and subsequent RSA increases (RSA rebound) were related to better anger and sadness regulation and more prosocial behavior. However, RSA was not significantly linked to adolescent aggressive behavior. We also compared the time course approach with the conventional linear approach and found that the time course approach provided more meaningful and rich information. The implications of adaptive RSA change patterns are discussed. (c) 2015 APA, all rights reserved).

Final cooling for a high-energy high-luminosity lepton collider

NASA Astrophysics Data System (ADS)

Neuffer, D.; Sayed, H.; Acosta, J.; Hart, T.; Summers, D.

2017-07-01

A high-energy muon collider requires a "final cooling" system that reduces transverse emittance by a factor of ~ 10, while allowing the longitudinal emittance to increase. The baseline approach has low-energy transverse cooling within high-field solenoids, with strong longitudinal heating. This approach and its recent simulation are discussed. Alternative approaches, which more explicitly include emittance exchange are also presented. Round-to-flat beam transform, transverse slicing, and longitudinal bunch coalescence are possible components of an alternative approach. Wedge-based emittance exchange could provide much of the required transverse cooling with longitudinal heating. Li-lens and quadrupole focusing systems could also provide much of the required final cooling.

Bolzano`s Approach to the Paradoxes of Infinity: Implications for Teaching

NASA Astrophysics Data System (ADS)

Waldegg, Guillermina

2005-08-01

In this paper we analyze excerpts of Paradoxes of the Infinite, the posthumous work of Bernard Bolzano (1781-1848), in order to show that Georg Cantor‘s (1845-1918) approach to the problem of defining actual mathematical infinity is not the most natural. In fact, Bolzano‘s approach to the paradoxes of infinity is more intuitive, while remaining internally coherent. Bolzano‘s approach, however, had limitations. We discuss implications for teaching, which include a better understanding of the responses of students to situations involving actual mathematical infinity, for it is possible to draw a kind of parallel between these responses and Bolzano‘s reasoning.

An Overview of the Management of Flexor Tendon Injuries

PubMed Central

Griffin, M; Hindocha, S; Jordan, D; Saleh, M; Khan, W

2012-01-01

Flexor tendon injuries still remain a challenging condition to manage to ensure optimal outcome for the patient. Since the first flexor tendon repair was described by Kirchmayr in 1917, several approaches to flexor tendon injury have enabled successful repairs rates of 70-90%. Primary surgical repair results in better functional outcome compared to secondary repair or tendon graft surgery. Flexor tendon injury repair has been extensively researched and the literature demonstrates successful repair requires minimal gapping at the repair site or interference with tendon vascularity, secure suture knots, smooth junction of tendon end and having sufficient strength for healing. However, the exact surgical approach to achieve success being currently used among surgeons is still controversial. Therefore, this review aims to discuss the results of studies demonstrating the current knowledge regarding the optimal approach for flexor tendon repair. Post-operative rehabilitation for flexor tendon surgery is another area, which has caused extensive debate in hand surgery. The trend to more active mobilisation protocols seems to be favoured but further study in this area is needed to find the protocol, which achieves function and gliding but avoids rupture of the tendons. Lastly despite success following surgery complications commonly still occur post surgery, including adhesion formation, tendon rupture and stiffness of the joints. Therefore, this review aims to discuss the appropriate management of these difficulties post surgery. New techniques in management of flexor tendon will also be discussed including external laser devices, addition of growth factors and cytokines. PMID:22431948

Review of methods to probe single cell metabolism and bioenergetics

PubMed Central

Vasdekis, Andreas E.; Stephanopoulos, Gregory

2015-01-01

Single cell investigations have enabled unexpected discoveries, such as the existence of biological noise and phenotypic switching in infection, metabolism and treatment. Herein, we review methods that enable such single cell investigations specific to metabolism and bioenergetics. Firstly, we discuss how to isolate and immobilize individuals from a cell suspension, including both permanent and reversible approaches. We also highlight specific advances in microbiology for its implications in metabolic engineering. Methods for probing single cell physiology and metabolism are subsequently reviewed. The primary focus therein is on dynamic and high-content profiling strategies based on label-free and fluorescence microspectroscopy and microscopy. Non-dynamic approaches, such as mass spectrometry and nuclear magnetic resonance, are also briefly discussed. PMID:25448400

Pacemakers and implantable cardioverter-defibrillators in pediatric patients.

PubMed

Silka, Michael J; Bar-Cohen, Yaniv

2006-11-01

The use of pacemakers and implantable cardioverter-defibrillators (ICDs) in infants, children, and patients with congenital heart disease presents unique challenges and considerations. They include uncommon indications for device implantation, innovative approaches to lead implantation and configuration, and age-dependent and disease-specific aspects of device programming. In this review, the current indications for pacemaker and ICD implantation in young patients are discussed, followed by consideration of the approaches to lead and device placement in very small patients and those with complex congenital heart disease, in whom unique problems may be encountered. The limitations of programmability of current pacemakers and ICDs when used in young patients are discussed, followed by an analysis of long-term device follow-up and potential late complications.

Biofluid lubrication for artificial joints

NASA Astrophysics Data System (ADS)

Pendleton, Alice Mae

This research investigated biofluid lubrication related to artificial joints using tribological and rheological approaches. Biofluids studied here represent two categories of fluids, base fluids and nanostructured biofluids. Base fluids were studied through comparison of synthetic fluids (simulated body fluid and hyaluronic acid) as well as natural biofluids (from dogs, horses, and humans) in terms of viscosity and fluid shear stress. The nano-structured biofluids were formed using molecules having well-defined shapes. Understanding nano-structured biofluids leads to new ways of design and synthesis of biofluids that are beneficial for artificial joint performance. Experimental approaches were utilized in the present research. This includes basic analysis of biofluids' property, such as viscosity, fluid shear stress, and shear rate using rheological experiments. Tribological investigation and surface characterization were conducted in order to understand effects of molecular and nanostructures on fluid lubrication. Workpiece surface structure and wear mechanisms were investigated using a scanning electron microscope and a transmission electron microscope. The surface topography was examined using a profilometer. The results demonstrated that with the adding of solid additives, such as crown ether or fullerene acted as rough as the other solids in the 3-body wear systems. In addition, the fullerene supplied low friction and low wear, which designates the lubrication purpose of this particular particle system. This dissertation is constructed of six chapters. The first chapter is an introduction to body fluids, as mentioned earlier. After Chapter II, it examines the motivation and approach of the present research, Chapter III discusses the experimental approaches, including materials, experimental setup, and conditions. In Chapter IV, lubrication properties of various fluids are discussed. The tribological properties and performance nanostructured biofluids are discussed in Chapter V, followed by summary and conclusions in Chapter VI.

A Belgian Approach to Learning Disabilities.

ERIC Educational Resources Information Center

Hayes, Cheryl W.

The paper reviews Belgian philosophy toward the education of learning disabled students and cites the differences between American behaviorally-oriented theory and Belgian emphasis on identifying the underlying causes of the disability. Academic methods observed in Belgium (including psychodrama and perceptual motor training) are discussed and are…

Institutional and Departmental Cultures: The Relationship Between Teaching and Research.

ERIC Educational Resources Information Center

Austin, Ann E.

1996-01-01

The influence of institutional and departmental cultures on the relationship between college teaching and research is discussed, and suggestions for assessing these factors and nurturing a positive relationship between them are made. Approaches include making reward systems more equitable, strengthening administrative leadership, encouraging…

Effective Management of a Volunteer Corps.

ERIC Educational Resources Information Center

Tedrick, Ted; And Others

1984-01-01

Prior to improving volunteer services, a leisure agency should have a realistic expectation of the desired accomplishments, both in individual and organizational terms. A systems approach to volunteer management is discussed that includes the components of planning and coordination; recruitment and orientation; training and placement; and…

Assessment and Treatment of Paraphilias.

ERIC Educational Resources Information Center

Seligman, Linda; Hardenburg, Stephanie A.

2000-01-01

Provides a description of the category of mental disorders called "paraphilias" and guidelines for assessment of people who present with paraphillic behavior. Includes a review of inventories that can facilitate diagnosis and description of paraphilias. Discusses effective approaches to treatment of these disorders as well as personal and…

Developing a Distributed Computing Architecture at Arizona State University.

ERIC Educational Resources Information Center

Armann, Neil; And Others

1994-01-01

Development of Arizona State University's computing architecture, designed to ensure that all new distributed computing pieces will work together, is described. Aspects discussed include the business rationale, the general architectural approach, characteristics and objectives of the architecture, specific services, and impact on the university…

Vol III Module 1: Management of Dyslexia and Related Learning Disabilities.

ERIC Educational Resources Information Center

Helveston, Eugene M.

1987-01-01

An ophthalmologist reviews the clinical features of dyslexia, gives guidelines for recognition and referral, discusses controversies regarding the management of learning disorders, and stresses the need for a multidisciplinary approach. Also included are the ophthalmologist's answers to practitioner questions. (Author/DB)

The Problems of Dissection.

ERIC Educational Resources Information Center

Davis, Pat

1997-01-01

Describes some problems of classroom dissection including the cruelty that animals destined for the laboratory suffer. Discusses the multilevel approach that the National Anti-Vivisection Society (NAVS) has developed to address the problems of animal dissection such as offering a dissection hotline, exhibiting at science teacher conferences, and…

A Course on Macromolecules.

ERIC Educational Resources Information Center

Horta, Arturo

1985-01-01

Describes a senior-level course that: (1) focuses on the structure and reactions of macromolecules; (2) treats industrial polymers in a unified way; and (3) uses analysis of conformation and conformational statistics as a unifying approach. Also discusses course topics, including polysaccharides, proteins, nucleic acids, and others. (JN)

Consulting Basics for the Teacher-Turned-Technology Consultant.

ERIC Educational Resources Information Center

Stager, Sue; Green, Kathy

1988-01-01

Discusses the role of educational technology consultants who may be classroom teachers with no formal training in consulting. Consulting models are described, including content-oriented and process-oriented approaches; Schein's process facilitator model is examined; and Kurpius' consulting model is explained and expanded. (LRW)

Ceramic technology for automotive turbines

NASA Technical Reports Server (NTRS)

Mclean, A. F.

1982-01-01

The paper presents an update on ceramic technology for automotive turbines. Progress in research and development of improved ceramics is reviewed, including approaches for assessing time-dependent strength characteristics. Processes for making shapes are discussed, and the design and testing of selected ceramic turbine components are reviewed.

Why We Should Establish a National System of Standards.

ERIC Educational Resources Information Center

Hennen, Thomas J., Jr.

2000-01-01

Explains the need to establish a national system of standards for public libraries. Discusses local standards, state standards, and international standards, and suggests adopting a tiered approach including three levels: minimum standards; target standards; and benchmarking standards, as found in total quality management. (LRW)

Characterizing Materials Sources and Sinks; Current Approaches: Part II. Chemical and Physical Characterization

EPA Science Inventory

The paper discusses methods for characterizing chemical emissions from material sources, including laboratory, dynamic chamber, and full-scale studies. Indoor sources and their interaction with sinks play a major role in determining indoor air quality (IAQ). Techniques for evalua...

Acing the Exam.

ERIC Educational Resources Information Center

Margolis, Rick

2002-01-01

Discusses improving student test scores based on an interview with Bob Berkowitz, co-developer of the Big6 approach to problem solving. Highlights include experiences at Wayne Central High School (Ontario Center, NY); cooperation between library media specialists and classroom teachers; viewing instruction as a series of information problems; and…

Fostering Rural/Corporate Partnerships.

ERIC Educational Resources Information Center

Vermillion, Mark

1986-01-01

Discusses how rural groups might approach corporations to forge partnerships for a variety of educational and community programs and activities. Makes specific suggestions for selecting corporations, writing the first requests for information, evaluating responses, and following up leads. Includes a section on the workings of Apple Computer's…

Severe Malnutrition: A Global Approach.

ERIC Educational Resources Information Center

Pelletier, Jean-Gerard

1993-01-01

This report examines the immediate and underlying causes of malnutrition in the developing world. The first section discusses the effects of malnutrition on childhood development and examines the efficacy of nutritional rehabilitation. The second section addresses the medical effects of severe malnutrition, including the onset of ponderostatural…

Viking Mars encounter

NASA Technical Reports Server (NTRS)

1976-01-01

Various phases of planetary operations related to the Viking mission to Mars are described. Topics discussed include: approach phase, Mars orbit insertion, prelanding orbital activities, separation, descent and landing, surface operations, surface sampling and operations starting, orbiter science and radio science, Viking 2, Deep Space Network and data handling.

Teaching Culturally Relevant Science.

ERIC Educational Resources Information Center

Marinez, Diana; Ortiz de Montellano, Bernard

For teachers concerned about the underrepresentation of Hispanics and Native Americans in science fields, this paper provides resource materials and instructional approaches. First, the role of ethnocentrism in determining what is included in science courses is discussed; the non-Western impact of science has been systematically ignored, it is…

Teaching Undergraduates to Think Like Scientists

ERIC Educational Resources Information Center

Caccavo, Frank, Jr.

2009-01-01

The author discusses the importance of incorporating research into undergraduate curricula. Pedagogical approaches include faculty-directed research projects, off-campus internships, and research-oriented courses (R-courses). Examples of R-courses are reviewed, and an introductory microbiology course that teaches first year students "how to do…

Note: The Numbering of Postgraduate Research.

ERIC Educational Resources Information Center

Wafford, Geoffrey

1984-01-01

Implications of the trend toward funding only graduate research projects that have a high likelihood of completion are discussed, including allocation of funds according to institutions' completion rates, deemphasis on research quality and students' personal development, and overemphasis on producing graduates. A more balanced approach to research…

Pat Conroy's "Gutter Language": "Prince of Tides" in a Lowcountry High School.

ERIC Educational Resources Information Center

White, Robert A.

1992-01-01

Describes the controversy sparked by Pat Conroy's novel "The Prince of Tides" when it was included in a reading list for an advanced-placement eleventh grade English class. Discusses Conroy's approach to writing and his experience as an unconventional teacher. (PRA)

Developing Strategies for Networked Education.

ERIC Educational Resources Information Center

Peregoy, Richard; Kroder, Stanley

2000-01-01

Assesses the strengths, weaknesses, opportunities and threats (SWOT) of the distance learning approach to education, and discusses how one institution, the University of Dallas Graduate School of Management, has developed a progressively expanding networked distance education program. Includes quotes from three students that suggest the quality of…

The Teaching of Cancer Medicine by Educational Objectives.

ERIC Educational Resources Information Center

Bakemeier, Richard F.; Myers, W. P. Laird

1984-01-01

Results of a survey of cancer education activities in 101 medical schools are discussed, including the needs for multidisciplinary instruction, more exposure of students to patients with common malignancies, and more uniform instruction in fundamental diagnostic procedures. An instructional approach relating educational objectives to departmental…

Eyeball to Eyeball: The Whys and Hows of Personal Solicitation.

ERIC Educational Resources Information Center

Robins, H. Perk

1982-01-01

Personal solicitation is seen as the most effective way to produce a gift. Specific steps for solicitation are identified: preparation, approach, presentation, and close. Leadership and volunteer training needed for the annual fund drive are discussed. University of Georgia examples are included. (MLW)

Two Approaches to Distance Education: Lessons Learned.

ERIC Educational Resources Information Center

Sedlak, Robert A.; Cartwright, G. Phillip

1997-01-01

Outlines lessons learned by the University of Wisconsin-Stout in implementing two distance education programs, a technology program using interactive television and a hospitality program using Lotus Notes to deliver courses. Topics discussed include program concept vs. technology as stimulus for innovation, program planning/administration,…

Dynamism in Electronic Performance Support Systems.

ERIC Educational Resources Information Center

Laffey, James

1995-01-01

Describes a model for dynamic electronic performance support systems based on NNAble, a system developed by the training group at Apple Computer. Principles for designing dynamic performance support are discussed, including a systems approach, performer-centered design, awareness of situated cognition, organizational memory, and technology use.…

Rethinking Recycling: Why Teach about Garbage?

ERIC Educational Resources Information Center

Clearing, 1993

1993-01-01

Ties environmental education, via garbage disposal issues, to Oregon's educational reform agenda. Discusses teaching the basics through "garbage" lessons. Includes how to (1) take an interdisciplinary approach; (2) introduce waste management concepts in other lessons; (3) use waste management examples to apply existing concepts; and (4)…

A Transactional Approach to "Sing" by Raposo and Lichtenheld

ERIC Educational Resources Information Center

Cardany, Audrey Berger

2014-01-01

Tom Lichtenheld shares a new story of the power of music by illustrating Joe Raposo's classic "Sesame Street" song "Sing." In addition to lesson suggestions for general music classes, a discussion of and application to the theory of transactional reading are included.

A Rainbow of Qualitative Approaches and Concerns.

ERIC Educational Resources Information Center

Fetterman, David M.

1987-01-01

Reviews the seven papers presented at a symposium entitled "Perennial Issues in Qualitative Research," part of the Annual Meeting of the American Educational Research Association (San Francisco, California, 1986), and included in this issue. Discusses the demonstrated usefulness of qualitative methods in educational research, and also…

OMEGA (Offshore Membrane for Enclosing Algae). NASA-NAVY: A Strategic Planning Discussion

NASA Technical Reports Server (NTRS)

Trent, Jonathan

2010-01-01

This briefing packet provides a short introduction to OMEGA and a truncated version of our project approach, with an example of the kind of work break down structure (WBS) used to guide our Phase I activities. It is meant to give you an impression of how we are approaching the challenge of creating the world's first marine photobioreactor (PBR) that will scale to address the strategic energy problems confronting the United States and the world. Some of our conceptual PBR designs and plans for logistics are included to communicate the path we have taken. We have also included an aerial photograph of the experimental tanks we are using at the Cal Fish and Game, followed by concluding remarks. The overarching purpose of the strategic planning discussion in Norfolk is to establish the relationship between the NASA OMEGA Team and the Navy, to unite the strengths of both agencies, and to map a mutual way forward along the project's established critical path.

Minimizing radiation exposure during percutaneous nephrolithotomy.

PubMed

Chen, T T; Preminger, G M; Lipkin, M E

2015-12-01

Given the recent trends in growing per capita radiation dose from medical sources, there have been increasing concerns over patient radiation exposure. Patients with kidney stones undergoing percutaneous nephrolithotomy (PNL) are at particular risk for high radiation exposure. There exist several risk factors for increased radiation exposure during PNL which include high Body Mass Index, multiple access tracts, and increased stone burden. We herein review recent trends in radiation exposure, radiation exposure during PNL to both patients and urologists, and various approaches to reduce radiation exposure. We discuss incorporating the principles of As Low As reasonably Achievable (ALARA) into clinical practice and review imaging techniques such as ultrasound and air contrast to guide PNL access. Alternative surgical techniques and approaches to reducing radiation exposure, including retrograde intra-renal surgery, retrograde nephrostomy, endoscopic-guided PNL, and minimally invasive PNL, are also highlighted. It is important for urologists to be aware of these concepts and techniques when treating stone patients with PNL. The discussions outlined will assist urologists in providing patient counseling and high quality of care.

Spacecraft rendezvous operational considerations affecting vehicle systems design and configuration

NASA Astrophysics Data System (ADS)

Prust, Ellen E.

One lesson learned from Orbiting Maneuvering Vehicle (OMV) program experience is that Design Reference Missions must include an appropriate balance of operations and performance inputs to effectively drive vehicle systems design and configuration. Rendezvous trajectory design is based on vehicle characteristics (e.g., mass, propellant tank size, and mission duration capability) and operational requirements, which have evolved through the Gemini, Apollo, and STS programs. Operational constraints affecting the rendezvous final approach are summarized. The two major objectives of operational rendezvous design are vehicle/crew safety and mission success. Operational requirements on the final approach which support these objectives include: tracking/targeting/communications; trajectory dispersion and navigation uncertainty handling; contingency protection; favorable sunlight conditions; acceptable relative state for proximity operations handover; and compliance with target vehicle constraints. A discussion of the ways each of these requirements may constrain the rendezvous trajectory follows. Although the constraints discussed apply to all rendezvous, the trajectory presented in 'Cargo Transfer Vehicle Preliminary Reference Definition' (MSFC, May 1991) was used as the basis for the comments below.

Inference and Prediction of Metabolic Network Fluxes

PubMed Central

Nikoloski, Zoran; Perez-Storey, Richard; Sweetlove, Lee J.

2015-01-01

In this Update, we cover the basic principles of the estimation and prediction of the rates of the many interconnected biochemical reactions that constitute plant metabolic networks. This includes metabolic flux analysis approaches that utilize the rates or patterns of redistribution of stable isotopes of carbon and other atoms to estimate fluxes, as well as constraints-based optimization approaches such as flux balance analysis. Some of the major insights that have been gained from analysis of fluxes in plants are discussed, including the functioning of metabolic pathways in a network context, the robustness of the metabolic phenotype, the importance of cell maintenance costs, and the mechanisms that enable energy and redox balancing at steady state. We also discuss methodologies to exploit 'omic data sets for the construction of tissue-specific metabolic network models and to constrain the range of permissible fluxes in such models. Finally, we consider the future directions and challenges faced by the field of metabolic network flux phenotyping. PMID:26392262

Recombinant proteins of helminths with immunoregulatory properties and their possible therapeutic use.

PubMed

Nascimento Santos, Leonardo; Carvalho Pacheco, Luis Gustavo; Silva Pinheiro, Carina; Alcantara-Neves, Neuza Maria

2017-02-01

The inverse relationship between helminth infections and the development of immune-mediated diseases is a cornerstone of the hygiene hypothesis and studies were carried out to elucidate the mechanisms by which helminth-derived molecules can suppress immunological disorders. These studies have fostered the idea that parasitic worms may be used as a promising therapeutic alternative for prevention and treatment of immune-mediated diseases. We discuss the current approaches for identification of helminth proteins with potential immunoregulatory properties, including the strategies based on high-throughput technologies. We also explore the methodological approaches and expression systems used for production of the recombinant forms of more than 20 helminth immunomodulatory proteins, besides their performances when evaluated as immunotherapeutic molecules to treat different immune-mediated conditions, including asthma and inflammatory bowel diseases. Finally, we discuss the perspectives of using these parasite-derived recombinant molecules as tools for future immunotherapy and immunoprophylaxis of human inflammatory diseases. Copyright © 2016. Published by Elsevier B.V.

An introduction to autonomous control systems

NASA Technical Reports Server (NTRS)

Antsaklis, Panos J.; Passino, Kevin M.; Wang, S. J.

1991-01-01

The functions, characteristics, and benefits of autonomous control are outlined. An autonomous control functional architecture for future space vehicles that incorporates the concepts and characteristics described is presented. The controller is hierarchical, with an execution level (the lowest level), coordination level (middle level), and management and organization level (highest level). The general characteristics of the overall architecture, including those of the three levels, are explained, and an example to illustrate their functions is given. Mathematical models for autonomous systems, including 'logical' discrete event system models, are discussed. An approach to the quantitative, systematic modeling, analysis, and design of autonomous controllers is also discussed. It is a hybrid approach since it uses conventional analysis techniques based on difference and differential equations and new techniques for the analysis of the systems described with a symbolic formalism such as finite automata. Some recent results from the areas of planning and expert systems, machine learning, artificial neural networks, and the area restructurable controls are briefly outlined.

Complex basis functions for molecular resonances: Methodology and applications

NASA Astrophysics Data System (ADS)

White, Alec; McCurdy, C. William; Head-Gordon, Martin

The computation of positions and widths of metastable electronic states is a challenge for molecular electronic structure theory because, in addition to the difficulty of the many-body problem, such states obey scattering boundary conditions. These resonances cannot be addressed with naïve application of traditional bound state electronic structure theory. Non-Hermitian electronic structure methods employing complex basis functions is one way that we may rigorously treat resonances within the framework of traditional electronic structure theory. In this talk, I will discuss our recent work in this area including the methodological extension from single determinant SCF-based approaches to highly correlated levels of wavefunction-based theory such as equation of motion coupled cluster and many-body perturbation theory. These approaches provide a hierarchy of theoretical methods for the computation of positions and widths of molecular resonances. Within this framework, we may also examine properties of resonances including the dependence of these parameters on molecular geometry. Some applications of these methods to temporary anions and dianions will also be discussed.

The pluralistic water research concept - a new human-water system research approach

NASA Astrophysics Data System (ADS)

Evers, Mariele; Höllermann, Britta; Almoradie, Adrian; Taft, Linda; Garcia-Santos, Glenda

2017-04-01

Sustainable water resources management has been and still is a main challenge for decision makers even though for the past number of decades integrative approaches and concepts (e.g. Integrated Water Resources Management - IWRM) have been developed to address problems on floods, droughts, water quality, water quantity, environment and ecology. Although somehow these approaches are aiming to address water related problems in an integrative approach and to some extent include or involve society in the planning and management, they still lack some of the vital components in including the social dimensions and their interaction with water. Understanding these dynamics in a holistic way and how they are shaped by time and space may tackle these shortcomings and provide more effective and sustainable management solutions with respect to a set of potential present social actions and values as well as possible futures. This paper aims to discuss challenges to coherently and comprehensively integrate the social dimensions of different human-water concepts like IWRM, socio-hydrology and waterscape. Against this background it will develop criteria for an integrative approach and present a newly developed concept termed pluralistic water research (PWR) concept. PWR is not only a pluralistic but also an integrative and interdisciplinary approach to acknowledge the social and water dimensions and their interaction and dynamics by considering more than one perspective of a water-related issue, hereby providing a set of multiple (future) developments. Our PWR concept will be illustrated by a case study application of the Canary island La Gomera. Furthermore an outlook on further possible developments of the PWR concept will be presented and discussed.

Discussing patient's lifestyle choices in the consulting room: analysis of GP-patient consultations between 1975 and 2008

PubMed Central

2010-01-01

Background The increasing prevalence of chronic diseases and the growing understanding that lifestyle behaviour plays an essential role in improving overall health suggest a need for increased attention to lifestyle choices in the consulting room. This study aims to examine whether or not healthy and unhealthy lifestyle choices of patients are currently being discussed more often in primary care consultations than in former decades. Furthermore, we are interested in GPs' approach to lifestyle behaviour during consultations. Lastly, we examine whether lifestyle behaviour is discussed more with certain patients during consultations, depending on gender, age and educational background. Method We analysed video-recordings of medical consultations, collected between 1975 and 2008 in Dutch GP practices. Data were analysed using logistic regression. Results This study shows that discussion of smoking behaviour and physical activity has increased somewhat over time. A change in discussion of nutrition and alcohol is, however, less clear. Overall, alcohol use is the least discussed and physical activity the most discussed during consultations. GPs mainly refer to lifestyle when it is relevant to the patient's complaints (symptom approach). GPs' approach to lifestyle behaviour did not change over time. In general, lifestyle behaviour is discussed more with older, male patients (except for nutrition). GPs talk about lifestyle behaviour with patients from different educational backgrounds equally (except for physical activity). Conclusion In recent years there is greater awareness of a healthy lifestyle, which is reflected to a limited extent in this study. Still, lifestyle behaviour is discussed in only a minority of consultations. GPs do not refer to lifestyle behaviour as a routine procedure, i.e. do not include it in primary prevention. This highlights the importance of the introduction of prevention consultations, where GPs can discuss lifestyle issues with patients who do not (yet) have risk symptoms. PMID:21062427

Reductionist Approach in Peptide-Based Nanotechnology.

PubMed

Gazit, Ehud

2018-06-20

The formation of ordered nanostructures by molecular self-assembly of proteins and peptides represents one of the principal directions in nanotechnology. Indeed, polyamides provide superior features as materials with diverse physical properties. A reductionist approach allowed the identification of extremely short peptide sequences, as short as dipeptides, which could form well-ordered amyloid-like β-sheet-rich assemblies comparable to supramolecular structures made of much larger proteins. Some of the peptide assemblies show remarkable mechanical, optical, and electrical characteristics. Another direction of reductionism utilized a natural noncoded amino acid, α-aminoisobutryic acid, to form short superhelical assemblies. The use of this exceptional helix inducer motif allowed the fabrication of single heptad repeats used in various biointerfaces, including their use as surfactants and DNA-binding agents. Two additional directions of the reductionist approach include the use of peptide nucleic acids (PNAs) and coassembly techniques. The diversified accomplishments of the reductionist approach, as well as the exciting future advances it bears, are discussed.

A Fully Immersive Set-Up for Remote Interaction and Neurorehabilitation Based on Virtual Body Ownership

PubMed Central

Perez-Marcos, Daniel; Solazzi, Massimiliano; Steptoe, William; Oyekoya, Oyewole; Frisoli, Antonio; Weyrich, Tim; Steed, Anthony; Tecchia, Franco; Slater, Mel; Sanchez-Vives, Maria V.

2012-01-01

Although telerehabilitation systems represent one of the most technologically appealing clinical solutions for the immediate future, they still present limitations that prevent their standardization. Here we propose an integrated approach that includes three key and novel factors: (a) fully immersive virtual environments, including virtual body representation and ownership; (b) multimodal interaction with remote people and virtual objects including haptic interaction; and (c) a physical representation of the patient at the hospital through embodiment agents (e.g., as a physical robot). The importance of secure and rapid communication between the nodes is also stressed and an example implemented solution is described. Finally, we discuss the proposed approach with reference to the existing literature and systems. PMID:22787454

Personalized translational epilepsy research - Novel approaches and future perspectives: Part I: Clinical and network analysis approaches.

PubMed

Rosenow, Felix; van Alphen, Natascha; Becker, Albert; Chiocchetti, Andreas; Deichmann, Ralf; Deller, Thomas; Freiman, Thomas; Freitag, Christine M; Gehrig, Johannes; Hermsen, Anke M; Jedlicka, Peter; Kell, Christian; Klein, Karl Martin; Knake, Susanne; Kullmann, Dimitri M; Liebner, Stefan; Norwood, Braxton A; Omigie, Diana; Plate, Karlheinz; Reif, Andreas; Reif, Philipp S; Reiss, Yvonne; Roeper, Jochen; Ronellenfitsch, Michael W; Schorge, Stephanie; Schratt, Gerhard; Schwarzacher, Stephan W; Steinbach, Joachim P; Strzelczyk, Adam; Triesch, Jochen; Wagner, Marlies; Walker, Matthew C; von Wegner, Frederic; Bauer, Sebastian

2017-11-01

Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy. In the context of these advances, the First International Symposium on Personalized Translational Epilepsy Research (1st ISymPTER) was held in Frankfurt on September 8, 2016, to discuss novel approaches and future perspectives for personalized translational research. These included new developments and ideas in a range of experimental and clinical areas such as deep phenotyping, quantitative brain imaging, EEG/MEG-based analysis of network dysfunction, tissue-based translational studies, innate immunity mechanisms, microRNA as treatment targets, functional characterization of genetic variants in human cell models and rodent organotypic slice cultures, personalized treatment approaches for monogenic epilepsies, blood-brain barrier dysfunction, therapeutic focal tissue modification, computational modeling for target and biomarker identification, and cost analysis in (monogenic) disease and its treatment. This report on the meeting proceedings is aimed at stimulating much needed investments of time and resources in personalized translational epilepsy research. Part I includes the clinical phenotyping and diagnostic methods, EEG network-analysis, biomarkers, and personalized treatment approaches. In Part II, experimental and translational approaches will be discussed (Bauer et al., 2017) [1]. Copyright © 2017 Elsevier Inc. All rights reserved.

Personalized translational epilepsy research - Novel approaches and future perspectives: Part II: Experimental and translational approaches.

PubMed

Bauer, Sebastian; van Alphen, Natascha; Becker, Albert; Chiocchetti, Andreas; Deichmann, Ralf; Deller, Thomas; Freiman, Thomas; Freitag, Christine M; Gehrig, Johannes; Hermsen, Anke M; Jedlicka, Peter; Kell, Christian; Klein, Karl Martin; Knake, Susanne; Kullmann, Dimitri M; Liebner, Stefan; Norwood, Braxton A; Omigie, Diana; Plate, Karlheinz; Reif, Andreas; Reif, Philipp S; Reiss, Yvonne; Roeper, Jochen; Ronellenfitsch, Michael W; Schorge, Stephanie; Schratt, Gerhard; Schwarzacher, Stephan W; Steinbach, Joachim P; Strzelczyk, Adam; Triesch, Jochen; Wagner, Marlies; Walker, Matthew C; von Wegner, Frederic; Rosenow, Felix

2017-11-01

Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics, and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy. In the context of these advances, the First International Symposium on Personalized Translational Epilepsy Research (1st ISymPTER) was held in Frankfurt on September 8, 2016, to discuss novel approaches and future perspectives for personalized translational research. These included new developments and ideas in a range of experimental and clinical areas such as deep phenotyping, quantitative brain imaging, EEG/MEG-based analysis of network dysfunction, tissue-based translational studies, innate immunity mechanisms, microRNA as treatment targets, functional characterization of genetic variants in human cell models and rodent organotypic slice cultures, personalized treatment approaches for monogenic epilepsies, blood-brain barrier dysfunction, therapeutic focal tissue modification, computational modeling for target and biomarker identification, and cost analysis in (monogenic) disease and its treatment. This report on the meeting proceedings is aimed at stimulating much needed investments of time and resources in personalized translational epilepsy research. This Part II includes the experimental and translational approaches and a discussion of the future perspectives, while the diagnostic methods, EEG network analysis, biomarkers, and personalized treatment approaches were addressed in Part I [1]. Copyright © 2017. Published by Elsevier Inc.

Sterilization: A Review and Update.

PubMed

Moss, Chailee; Isley, Michelle M

2015-12-01

Sterilization is a frequently used method of contraception. Female sterilization is performed 3 times more frequently than male sterilization, and it can be performed immediately postpartum or as an interval procedure. Methods include mechanical occlusion, coagulation, or tubal excision. Female sterilization can be performed using an abdominal approach, or via laparoscopy or hysteroscopy. When an abdominal approach or laparoscopy is used, sterilization occurs immediately. When hysteroscopy is used, tubal occlusion occurs over time, and additional testing is needed to confirm tubal occlusion. Comprehensive counseling about sterilization should include discussion about male sterilization (vasectomy) and long-acting reversible contraceptive methods. Copyright © 2015 Elsevier Inc. All rights reserved.

Pantex Falling Man - Independent Review Panel Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bertolini, Louis; Brannon, Nathan; Olson, Jared

2014-11-01

Consolidated Nuclear Security (CNS) Pantex took the initiative to organize a Review Panel of subject matter experts to independently assess the adequacy of the Pantex Tripping Man Analysis methodology. The purpose of this report is to capture the details of the assessment including the scope, approach, results, and detailed Appendices. Along with the assessment of the analysis methodology, the panel evaluated the adequacy with which the methodology was applied as well as congruence with Department of Energy (DOE) standards 3009 and 3016. The approach included the review of relevant documentation, interactive discussion with Pantex staff, and the iterative process ofmore » evaluating critical lines of inquiry.« less

Flank and Lumbar Hernia Repair.

PubMed

Beffa, Lucas R; Margiotta, Alyssa L; Carbonell, Alfredo M

2018-06-01

Flank and lumbar hernias are challenging because of their rarity and anatomic location. Several challenges exist when approaching these specific abdominal wall defects, including location, innervation of the lateral abdominal wall musculature, and their proximity to bony landmarks. These hernias are confined by the costal margin, spine, and pelvic brim, which makes closure of the defect, including mesh placement, difficult. This article discusses the anatomy of lumbar and flank hernias, the various etiologies for these hernias, and the procedural steps for open and robotic preperitoneal approaches. The available clinical evidence regarding outcomes for various repair techniques is also reviewed. Copyright © 2018 Elsevier Inc. All rights reserved.

Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier

PubMed Central

Villa, Carlos H; Pan, Daniel C; Zaitsev, Sergei; Cines, Douglas B; Siegel, Donald L; Muzykantov, Vladimir R

2015-01-01

For several decades, researchers have used erythrocytes for drug delivery of a wide variety of therapeutics in order to improve their pharmacokinetics, biodistribution, controlled release and pharmacodynamics. Approaches include encapsulation of drugs within erythrocytes, as well as coupling of drugs onto the red cell surface. This review focuses on the latter approach, and examines the delivery of red blood cell (RBC)-surface-bound anti-inflammatory, anti-thrombotic and anti-microbial agents, as well as RBC carriage of nanoparticles. Herein, we discuss the progress that has been made in surface loading approaches, and address in depth the issues relevant to surface loading of RBC, including intrinsic features of erythrocyte membranes, immune considerations, potential surface targets and techniques for the production of affinity ligands. PMID:26228773

Measuring Children’s Media Use in the Digital Age

PubMed Central

Vandewater, Elizabeth A.; Lee, Sook-Jung

2009-01-01

In this new and rapidly changing era of digital technology, there is increasing consensus among media scholars that there is an urgent need to develop measurement approaches which more adequately capture media use The overarching goal of this paper is facilitate the development of measurement approaches appropriate for capturing children’s media use in the digital age. The paper outlines various approaches to measurement, focusing mainly on those which have figured prominently in major existing studies of children’s media use. We identify issues related to each technique, including advantages and disadvantages. We also include a review of existing empirical comparisons of various methodologies. The paper is intended to foster discussion of the best ways to further research and knowledge regarding the impact of media on children. PMID:19763246

Multiple Paths to Mathematics Practice in Al-Kashi's Key to Arithmetic

NASA Astrophysics Data System (ADS)

Taani, Osama

2014-01-01

In this paper, I discuss one of the most distinguishing features of Jamshid al-Kashi's pedagogy from his Key to Arithmetic, a well-known Arabic mathematics textbook from the fifteenth century. This feature is the multiple paths that he includes to find a desired result. In the first section light is shed on al-Kashi's life and his contributions to mathematics and astronomy. Section 2 starts with a brief discussion of the contents and pedagogy of the Key to Arithmetic. Al-Kashi's multiple approaches are discussed through four different examples of his versatility in presenting a topic from multiple perspectives. These examples are multiple definitions, multiple algorithms, multiple formulas, and multiple methods for solving word problems. Section 3 is devoted to some benefits that can be gained by implementing al-Kashi's multiple paths approach in modern curricula. For this discussion, examples from two teaching modules taken from the Key to Arithmetic and implemented in Pre-Calculus and mathematics courses for preservice teachers are discussed. Also, the conclusions are supported by some aspects of these modules. This paper is an attempt to help mathematics educators explore more benefits from reading from original sources.

Comparison of approaches to Total Quality Management. Including an examination of the Department of Energy`s position on quality management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, C.T.

1994-03-01

This paper presents a comparison of several qualitatively different approaches to Total Quality Management (TQM). The continuum ranges from management approaches that are primarily standards -- with specific guidelines, but few theoretical concepts -- to approaches that are primarily philosophical, with few specific guidelines. The approaches to TQM discussed in this paper include the International Organization for Standardization (ISO) 9000 Standard, the Malcolm Baldrige National Quality Award, Senge`s the Learning Organization, Watkins and Marsick`s approach to organizational learning, Covey`s Seven Habits of Highly Successful People, and Deming`s Fourteen Points for Management. Some of these approaches (Deming and ISO 9000) aremore » then compared to the DOE`s official position on quality management and conduct of operations (DOE Orders 5700.6C and 5480.19). Using a tabular format, it is shown that while 5700.6C (Quality Assurance) maps well to many of the current approaches to TQM, DOE`s principle guide to management Order 5419.80 (Conduct of Operations) has many significant conflicts with some of the modern approaches to continuous quality improvement.« less

Status of NO sub x control for coal-fired power plants

NASA Technical Reports Server (NTRS)

Teixeira, D. P.

1978-01-01

The status of technologies for controlling emissions of oxides of nitrogen (NOx) from coal-fired power plants is reviewed. A discussion of current technology as well as future NOx control approaches is presented. Advanced combustion approaches are included as well as post-combustion alternatives such as catalytic and noncatalytic ammonia-bases systems and wet scrubbing. Special emphasis is given to unresolved development issues as they relate to practical applications on coal-fired power plants.

Space Station fluid management logistics

NASA Technical Reports Server (NTRS)

Dominick, Sam M.

1990-01-01

Viewgraphs and discussion on space station fluid management logistics are presented. Topics covered include: fluid management logistics - issues for Space Station Freedom evolution; current fluid logistics approach; evolution of Space Station Freedom fluid resupply; launch vehicle evolution; ELV logistics system approach; logistics carrier configuration; expendable fluid/propellant carrier description; fluid carrier design concept; logistics carrier orbital operations; carrier operations at space station; summary/status of orbital fluid transfer techniques; Soviet progress tanker system; and Soviet propellant resupply system observations.

Art, Objects, and Beautiful Stories: A "New" Approach to Spiritual Care.

PubMed

Smith, Aaron P B; Read, Julia E

2017-06-01

The use of story, and the use of art or various arts-based techniques have become popular in a number of helping professions, including spiritual care. There remains a gap in the literature, however, in which an approach comprised of both story and art or objects is explored. This paper addresses this gap by discussing the experience, theory, benefits, and technique of combining story and art or object-based techniques for the provision of spiritual care.

Data-intensive computing on numerically-insensitive supercomputers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahrens, James P; Fasel, Patricia K; Habib, Salman

2010-12-03

With the advent of the era of petascale supercomputing, via the delivery of the Roadrunner supercomputing platform at Los Alamos National Laboratory, there is a pressing need to address the problem of visualizing massive petascale-sized results. In this presentation, I discuss progress on a number of approaches including in-situ analysis, multi-resolution out-of-core streaming and interactive rendering on the supercomputing platform. These approaches are placed in context by the emerging area of data-intensive supercomputing.

Objectives, Budgets, Thresholds, and Opportunity Costs-A Health Economics Approach: An ISPOR Special Task Force Report [4].

PubMed

Danzon, Patricia M; Drummond, Michael F; Towse, Adrian; Pauly, Mark V

2018-02-01

The fourth section of our Special Task Force report focuses on a health plan or payer's technology adoption or reimbursement decision, given the array of technologies, on the basis of their different values and costs. We discuss the role of budgets, thresholds, opportunity costs, and affordability in making decisions. First, we discuss the use of budgets and thresholds in private and public health plans, their interdependence, and connection to opportunity cost. Essentially, each payer should adopt a decision rule about what is good value for money given their budget; consistent use of a cost-per-quality-adjusted life-year threshold will ensure the maximum health gain for the budget. In the United States, different public and private insurance programs could use different thresholds, reflecting the differing generosity of their budgets and implying different levels of access to technologies. In addition, different insurance plans could consider different additional elements to the quality-adjusted life-year metric discussed elsewhere in our Special Task Force report. We then define affordability and discuss approaches to deal with it, including consideration of disinvestment and related adjustment costs, the impact of delaying new technologies, and comparative cost effectiveness of technologies. Over time, the availability of new technologies may increase the amount that populations want to spend on health care. We then discuss potential modifiers to thresholds, including uncertainty about the evidence used in the decision-making process. This article concludes by discussing the application of these concepts in the context of the pluralistic US health care system, as well as the "excess burden" of tax-financed public programs versus private programs. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Decision Making and Cancer

PubMed Central

Reyna, Valerie F.; Nelson, Wendy L.; Han, Paul K.; Pignone, Michael P.

2014-01-01

We review decision-making along the cancer continuum in the contemporary context of informed and shared decision making, in which patients are encouraged to take a more active role in their health care. We discuss challenges to achieving informed and shared decision making, including cognitive limitations and emotional factors, but argue that understanding the mechanisms of decision making offers hope for improving decision support. Theoretical approaches to decision making that explain cognition, emotion, and their interaction are described, including classical psychophysical approaches, dual-process approaches that focus on conflicts between emotion versus cognition (or reason), and modern integrative approaches such as fuzzy-trace theory. In contrast to the earlier emphasis on rote use of numerical detail, modern approaches emphasize understanding the bottom-line gist of options (which encompasses emotion and other influences on meaning) and retrieving relevant social and moral values to apply to those gist representations. Finally, research on interventions to support better decision making in clinical settings is reviewed, drawing out implications for future research on decision making and cancer. PMID:25730718

Clinical challenges in thyroid disease: Time for a new approach?

PubMed

Juby, A G; Hanly, M G; Lukaczer, D

2016-05-01

Thyroid disease is common, and the prevalence is rising. Traditional diagnosis and monitoring relies on thyroid stimulating hormone (TSH) levels. This does not always result in symptomatic improvement in hypothyroid symptoms, to the disappointment of both patients and physicians. A non-traditional therapeutic approach would include evaluation of GI function as well as a dietary history and micronutrient evaluation. This approach also includes assessment of thyroid peroxidase (TPO) antibodies, T3, T4, and reverse T3 levels, and in some cases may require specific T3 supplementation in addition to standard T4 therapy. Both high and low TSH levels on treatment are associated with particular medical risks. In the case of high TSH this is primarily cardiac, whereas for low TSH it is predominantly bone health. This article discusses these important clinical issues in more detail, with some practical tips especially for an approach to the "non-responders" to the current traditional therapeutic approach. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The Benefits of Movement for Youth: A Whole Child Approach

ERIC Educational Resources Information Center

Savina, Elena; Garrity, Kristin; Kenny, Patrick; Doerr, Chad

2016-01-01

This paper synthesizes studies on the benefits of movement on youth's health, cognition, and academic performance. It discusses behavioral and cognitive outcomes of different types of movement activities including physical activities integrated into teaching of academic content, classroom exercise breaks, afterschool exercise programs, and active…

Pedagogical Issues in Object Orientation.

ERIC Educational Resources Information Center

Nerur, Sridhar; Ramanujan, Sam; Kesh, Someswar

2002-01-01

Discusses the need for people with object-oriented (OO) skills, explains benefits of OO in software development, and addresses some of the difficulties in teaching OO. Topics include the evolution of programming languages; differences between OO and traditional approaches; differences from data modeling; and Unified Modeling Language (UML) and…

Adapting for Impaired Patrons.

ERIC Educational Resources Information Center

Schuyler, Michael

1999-01-01

Describes how a library, with an MCI Corporation grant, approached the process of setting up computers for the visually impaired. Discusses preparations, which included hiring a visually-impaired user as a consultant and contacting the VIP (Visually Impaired Persons) group; equipment; problems with the graphical user interface; and training.…

Computers and Health--Individual and Institutional Protective Measures.

ERIC Educational Resources Information Center

Updegrove, Daniel A.; Updegrove, Kimberly H.

1991-01-01

Two issues related to computers and health are discussed: ergonomics/work habits and radiation hazards. Several approaches that colleges and universities might use to promote workplace safety are suggested, including education, training, and more informed purchasing. San Francisco's new worker safety ordinance is presented, and carpal tunnel…

A New Methodology for Systematic Exploitation of Technology Databases.

ERIC Educational Resources Information Center

Bedecarrax, Chantal; Huot, Charles

1994-01-01

Presents the theoretical aspects of a data analysis methodology that can help transform sequential raw data from a database into useful information, using the statistical analysis of patents as an example. Topics discussed include relational analysis and a technology watch approach. (Contains 17 references.) (LRW)

Teaching Marketing Strategy: Using Resource-Advantage Theory as an Integrative Theoretical Foundation

ERIC Educational Resources Information Center

Hunt, Shelby D.; Madhavaram, Sreedhar

2006-01-01

Knowledge of marketing strategy is essential for marketing majors. To supplement and/or replace the traditional lecture-discussion approach, several pedagogical vehicles have been recommended to teach marketing strategy, including the analytic hierarchy process; career-planning cases; computer-assisted, simulated marketing cases; experiential…

Physics of Materials.

ERIC Educational Resources Information Center

Archenhold, W. F.; And Others

1987-01-01

Describes a new high school physics option in Great Britain which uses the model of a technological approach to the study of materials. Discusses the components of the program, including the development of a student book for independent learning and six case studies. Provides a case study about turbine blades. (TW)

Addressing Gender Equity in Nonfaculty Salaries.

ERIC Educational Resources Information Center

Toukoushian, Robert K.

2000-01-01

Discusses methodology of gender equity studies on noninstructional employees of colleges and universities, including variable selection in the multiple regression model and alternative approaches for measuring wage gaps. Analysis of staff data at one institution finds that experience and market differences account for 80 percent of gender pay…

An Echo, Not a Choice.

ERIC Educational Resources Information Center

Dewey, Douglas D.

1996-01-01

Discusses why government school vouchers actually represent a setback to school reform and only contribute to diminishing school autonomy and distinctiveness. Argues use of a privately funded voucher system or precollege scholarship approach as feasible alternatives for educating low-income children. Alternatives include the need for tax relief,…

Counselor Training: Empirical Findings and Current Approaches

ERIC Educational Resources Information Center

Buser, Trevor J.

2008-01-01

The literature on counselor training has included attention to cognitive and interpersonal skill development and has reported on empirical findings regarding the relationship of training with client outcomes. This article reviews the literature on each of these topics and discusses empirical and theoretical underpinnings of recently developed…

Making Peace in Violent Times: A Constructivist Approach to Conflict Resolution.

ERIC Educational Resources Information Center

Carlsson-Paige, Nancy; Levin, Diane E.

1992-01-01

Suggests actions that teachers can take to challenge the use of violence by children. Actions include providing early intervention and teaching specific skills to help children resolve conflicts. Discusses adaptation to children's developmental levels and creation of classroom contexts supportive of nonviolence. (LB)

Compulsory Birth Control and Fertility Measures in India.

ERIC Educational Resources Information Center

Halli, S. S.

1983-01-01

Discussion of possible applications of the microsimulation approach to analysis of population policy proposes compulsory sterilization policy for all of India. Topics covered include India's population problem, methods for generating a distribution of couples to be sterilized, model validation, data utilized, data analysis, program limitations,…

Merging the Internet and Hypermedia in the English Language Arts.

ERIC Educational Resources Information Center

Reed, W. Michael; Wells, John G.

1997-01-01

Discussion of hypermedia and computer-mediated communication focuses on a project that merges a language arts Internet resource with a hypermedia-based knowledge construction approach to learning. Highlights include constructing a HyperCard-based program on Shakespeare's "Hamlet," gophers and search engines, downloading, collaborative…

Streamline Your Project: A Lifecycle Model.

ERIC Educational Resources Information Center

Viren, John

2000-01-01

Discusses one approach to project organization providing a baseline lifecycle model for multimedia/CBT development. This variation of the standard four-phase model of Analysis, Design, Development, and Implementation includes a Pre-Analysis phase, called Definition, and a Post-Implementation phase, known as Maintenance. Each phase is described.…

Minicourses in Astrophysics, Modular Approach, Vol. I.

ERIC Educational Resources Information Center

Illinois Univ., Chicago.

This is the first volume of a two-volume minicourse in astrophysics. It contains chapters on the following topics: planetary atmospheres; X-ray astronomy; radio astrophysics; molecular astrophysics; and gamma-ray astrophysics. Each chapter gives much technical discussion, mathematical treatment, diagrams, and examples. References are included with…

Comets. [IUE

NASA Technical Reports Server (NTRS)

Ahearn, Michael F.

1988-01-01

The IUE was used to study comets including the first dynamically new comet to approach closer than 3 AU. Differences between old and new comets are studied. Results relevant to the nature of cometary nuclei are discussed. Identification of species in the spectra; relative abundances; variability of comets; and comet mass are considered.

Diversity Training with a Dramatic Flair.

ERIC Educational Resources Information Center

Wilson, Jennifer B.

1998-01-01

Describes the "social action theater" approach to diversity training in colleges and universities. The method uses one-act plays to present diversity issues in a way that creates conflict among characters and promotes audience discussion. Issues in using social-action theater are examined, including benefits, determining level of campus…

Assessing Conformity to Standards for Treatment Foster Care.

ERIC Educational Resources Information Center

Farmer, Elizabeth M. Z.; Burns, Barbara J.; Dubs, Melanie S.; Thompson, Shealy

2002-01-01

This study examined conformity to the Program Standards for Treatment Foster Care among 42 statewide programs. Findings suggest fair to good overall conformity, with considerable variation among programs. A discussion of methodological and substantive considerations for future research and evaluation using this approach is included. (Contains…

Ceramics Curriculum: What Has It Been? What Could it Be?

ERIC Educational Resources Information Center

Sessions, Billie

1999-01-01

Reviews the traditional approach to ceramics education that focuses on studio-based, formalist curriculum and Modernist concerns. Argues for a comprehensive, or contextual, ceramics education in high school classrooms that would include contextual information about ceramic objects. Discusses example ceramic objects by various artists. (CMK)

The Future of Clinical Dentistry.

ERIC Educational Resources Information Center

Slavkin, Harold C.

1998-01-01

Discussion of the future of clinical dentistry looks at a variety of influences, including historical development factors; demographic trends; the role of the Human Genome Project in the development of scientific knowledge; a paradigm shift in approaches to oral infection and systemic disease; advancing technology; and reforms resulting from these…

Black Teenage Pregnancy: A Challenge for Educators.

ERIC Educational Resources Information Center

Ladner, Joyce A.

1987-01-01

Analyzes the impact of teen pregnancy on the education of Black adolescents. Examines the scope of the problem, its social context, and its consequences. Discusses several effective approaches to teenage pregnancy prevention, including sex/family life education, school-based health clinics, life skills instruction, school retention, and…

The Improvement of Higher Education in Indonesia: A Project Approach.

ERIC Educational Resources Information Center

Ruitjer, Kees; Utomo, Tjipto

1983-01-01

An international project for improvement of an Indonesian university's chemical engineering curriculum and later extended to other institutions and departments, included these changes: greater emphasis on discussion and problem-solving techniques, use of learning modules, introduction of criterion-referenced grading, and extended and improved…

Teaching the Public Relations Campaigns Course.

ERIC Educational Resources Information Center

Worley, Debra A.

2001-01-01

Argues for a Campaign Planning Course in the undergraduate public relations major. Discusses nine course objectives. Describes five phases of campaign planning and implementation, how the phase approach includes important course topics, and how it fulfills course objectives. Describes how student groups work with actual clients throughout the…

Autonomous Mars ascent and orbit rendezvous for earth return missions

NASA Technical Reports Server (NTRS)

Edwards, H. C.; Balmanno, W. F.; Cruz, Manuel I.; Ilgen, Marc R.

1991-01-01

The details of tha assessment of autonomous Mars ascent and orbit rendezvous for earth return missions are presented. Analyses addressing navigation system assessments, trajectory planning, targeting approaches, flight control guidance strategies, and performance sensitivities are included. Tradeoffs in the analysis and design process are discussed.

Aerospace electrode line

NASA Technical Reports Server (NTRS)

Miller, L.

1980-01-01

A facility which produces electrodes for spacecraft power supplies is described. The electrode assembly procedures are discussed. A number of design features in the production process are reported including a batch operation mode and an independent equipment module design approach for transfering the electrode materials from process tank to process tank.

Relaxation Techniques for Handicapped Children: A Review of Literature.

ERIC Educational Resources Information Center

Zipkin, Dvora

1985-01-01

The paper discusses four major relaxation training approaches used with handicapped children: progressive muscle relaxation, biofeedback, yoga, and mental relaxation, which includes guided fantasy, imagery, and meditation. Descriptions of these techniques, the effects of their use with various populations, and reviews of recent studies of their…

Strategic Positioning of the Web in a Multi-Channel Market Approach.

ERIC Educational Resources Information Center

Simons, Luuk P. A.; Steinfield, Charles; Bouwman, Harry

2002-01-01

Discusses channel economics in retail activities and trends toward unbundling due to the emergence of the Web channel. Highlights include sales processes and physical distribution processes; transaction costs; hybrid electronic commerce strategies; channel management and customer support; information economics, thing economics, and service…

Acute Traumatic Coagulopathy

DTIC Science & Technology

2014-12-01

therapeutic approaches are discussed, including viscoelastic coagulation monitoring and the role of tranexamic acid and blood products. Summary...and tranexamic acid in addition to red cell units in order to reduce bleeding and improve clinical outcomes. Keywords acute traumatic coagulopathy...endothelial activation, fibrinolysis, hemostatic resuscitation, hypoperfusion, microparticles, platelet dysfunction, tranexamic acid , viscoelastic

Towards the Architecture of an Instructional Multimedia Database.

ERIC Educational Resources Information Center

Verhagen, Plin W.; Bestebreurtje, R.

1994-01-01

Discussion of multimedia databases in education focuses on the development of an adaptable database in The Netherlands that uses optical storage media to hold the audiovisual components. Highlights include types of applications; types of users; accessibility; adaptation; an object-oriented approach; levels of the database architecture; and…

The Geography Curriculum and Its Contents: Preparing for the Twenty-First Century in Argentina Geography Education.

ERIC Educational Resources Information Center

Montiel, Gloria Z. de

1996-01-01

Considers the various educational philosophies governing geography instruction in Argentina and places them in historical perspective. Contrasts the positivist and historicist approaches and discusses the current curriculum. Includes summaries of proposed changes in the curriculum emphasizing social education. (MJP)

The Genetic Blues: Understanding Genetic Principles Using a Practical Approach and a Historical Perspective.

ERIC Educational Resources Information Center

Mysliwiec, Tami H.

2003-01-01

Incorporates history and genetics to explain how genetic traits are passed on to the next generation by focusing on methemoglobinemia, a rare genetic disease, and discusses how oxygen is carried by hemoglobin. Includes individual pedigree analysis and class pedigree analysis. (YDS)

Plagiarism: Moving from Punitive to Proactive Approaches

ERIC Educational Resources Information Center

Eaton, Sarah Elaine; Guglielmin, Melanie; Otoo, Benedict Kojo

2017-01-01

Plagiarism continues to be an issue in postsecondary contexts. This paper discusses how educators can take a proactive stance to prevent plagiarism and cultivate students' sense of honour and academic integrity, rather than focusing on punitive consequences after plagiarism has already occurred. Strategies include assessment design, formative…

Multimedia Applications in Heterogeneous Internet/ATM Environments.

ERIC Educational Resources Information Center

Wolf, Lars C.

1999-01-01

Discussion of multimedia systems focuses on interaction approaches for the quality of service (QoS) architectures developed for the Internet and for asynchronous transfer mode (ATM). Highlights include interactions, videoconferencing, video on demand, a comparison of the ATM and IntServ QoS architectures, interaction models, and subordination…

Language Disorders of Children: The Bases and Diagnoses.

ERIC Educational Resources Information Center

Berry, Mildred Freburg

Taking an interdisciplinary approach, the text is intended as an introduction to language disorders in children. Aspects of tracking language in the nervous system considered include neural substrates of language development, operational systems, and operational mechanisms. Language and learning are discussed in terms of the psychological…