Sample records for approaches implicate osteoglycin

  1. High expression of osteoglycin decreases gelatinase activity of murine hepatocarcinoma Hca-F cells

    PubMed Central

    Cui, Xiao-Nan; Tang, Jian-Wu; Song, Bo; Wang, Bo; Chen, Shan-Yan; Hou, Li

    2009-01-01

    AIM: To investigate the possible correlation between osteoglycin expression and gelatinase activity of mouse hepatocarcinoma Hca-F cells. METHODS: A eukaryotic expression plasmid pIRESpuro3 osteoglycin(+) was constructed and transfected into Hca-F cells to investigate the possible correlation between osteoglycin expression and gelatinase activity of Hca-F cells cultured with extract of lymph node, liver, spleen or in DMEM medium. The activity of gelatinases was examined through zymographic analysis. RESULTS: High expression of osteoglycin attenuated the gelatinase activity of Hca-F cells cultured with extract of lymph node, and at the same time, decreased the metastatic potential of Hca-F cells to peripheral lymph nodes in vivo. CONCLUSION: High expression of osteoglycin decreases the gelatinase activity of Hca-F cells cultured with extract of lymph node; regulation of gelatinase activity might be one of mechanisms that osteoglycin contributes to lymphatic metastasis suppression. PMID:20027687

  2. C/EBPβ LIP augments cell death by inducing osteoglycin.

    PubMed

    Wassermann-Dozorets, Rina; Rubinstein, Menachem

    2017-04-06

    Many types of tumor cell are devoid of the extracellular matrix proteoglycan osteoglycin (Ogn), but its role in tumor biology is poorly studied. Here we show that RNAi of Ogn attenuates stress-triggered cell death, whereas its overexpression increases cell death. We found that the transcription factor C/EBPβ regulates the expression of Ogn. C/EBPβ is expressed as a full-length, active form (LAP) and as a truncated, dominant-negative form (LIP), and the LIP/LAP ratio is positively correlated with the extent of cell death under stress. For example, we reported that drug-resistant tumor cells lack LIP altogether, and its supplementation abolished their resistance to chemotherapy and to endoplasmic reticulum (ER) stress. Here we further show that elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1). Our findings suggest that LIP deficiency renders tumor cell resistant to ER stress by preventing the induction of Ogn.

  3. Decreased expression of extracellular matrix proteins and trophic factors in the amygdala complex of depressed mice after chronic immobilization stress

    PubMed Central

    2012-01-01

    Background The amygdala plays an essential role in controlling emotional behaviors and has numerous connections to other brain regions. The functional role of the amygdala has been highlighted by various studies of stress-induced behavioral changes. Here we investigated gene expression changes in the amygdala in the chronic immobilization stress (CIS)-induced depression model. Results Eight genes were decreased in the amygdala of CIS mice, including genes for neurotrophic factors and extracellular matrix proteins. Among these, osteoglycin, fibromodulin, insulin-like growth factor 2 (Igf2), and insulin-like growth factor binding protein 2 (Igfbp2) were further analyzed for histological expression changes. The expression of osteoglycin and fibromodulin simultaneously decreased in the medial, basolateral, and central amygdala regions. However, Igf2 and Igfbp2 decreased specifically in the central nucleus of the amygdala. Interestingly, this decrease was found only in the amygdala of mice showing higher immobility, but not in mice displaying lower immobility, although the CIS regimen was the same for both groups. Conclusions These results suggest that the responsiveness of the amygdala may play a role in the sensitivity of CIS-induced behavioral changes in mice. PMID:22672618

  4. Defining the role of common variation in the genomic and biological architecture of adult human height.

    PubMed

    Wood, Andrew R; Esko, Tonu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H; Gustafsson, Stefan; Chu, Audrey Y; Estrada, Karol; Luan, Jian'an; Kutalik, Zoltán; Amin, Najaf; Buchkovich, Martin L; Croteau-Chonka, Damien C; Day, Felix R; Duan, Yanan; Fall, Tove; Fehrmann, Rudolf; Ferreira, Teresa; Jackson, Anne U; Karjalainen, Juha; Lo, Ken Sin; Locke, Adam E; Mägi, Reedik; Mihailov, Evelin; Porcu, Eleonora; Randall, Joshua C; Scherag, André; Vinkhuyzen, Anna A E; Westra, Harm-Jan; Winkler, Thomas W; Workalemahu, Tsegaselassie; Zhao, Jing Hua; Absher, Devin; Albrecht, Eva; Anderson, Denise; Baron, Jeffrey; Beekman, Marian; Demirkan, Ayse; Ehret, Georg B; Feenstra, Bjarke; Feitosa, Mary F; Fischer, Krista; Fraser, Ross M; Goel, Anuj; Gong, Jian; Justice, Anne E; Kanoni, Stavroula; Kleber, Marcus E; Kristiansson, Kati; Lim, Unhee; Lotay, Vaneet; Lui, Julian C; Mangino, Massimo; Mateo Leach, Irene; Medina-Gomez, Carolina; Nalls, Michael A; Nyholt, Dale R; Palmer, Cameron D; Pasko, Dorota; Pechlivanis, Sonali; Prokopenko, Inga; Ried, Janina S; Ripke, Stephan; Shungin, Dmitry; Stancáková, Alena; Strawbridge, Rona J; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W; van Setten, Jessica; Van Vliet-Ostaptchouk, Jana V; Wang, Zhaoming; Yengo, Loïc; Zhang, Weihua; Afzal, Uzma; Arnlöv, Johan; Arscott, Gillian M; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J; Berne, Christian; Blüher, Matthias; Bolton, Jennifer L; Böttcher, Yvonne; Boyd, Heather A; Bruinenberg, Marcel; Buckley, Brendan M; Buyske, Steven; Caspersen, Ida H; Chines, Peter S; Clarke, Robert; Claudi-Boehm, Simone; Cooper, Matthew; Daw, E Warwick; De Jong, Pim A; Deelen, Joris; Delgado, Graciela; Denny, Josh C; Dhonukshe-Rutten, Rosalie; Dimitriou, Maria; Doney, Alex S F; Dörr, Marcus; Eklund, Niina; Eury, Elodie; Folkersen, Lasse; Garcia, Melissa E; Geller, Frank; Giedraitis, Vilmantas; Go, Alan S; Grallert, Harald; Grammer, Tanja B; Gräßler, Jürgen; Grönberg, Henrik; de Groot, Lisette C P G M; Groves, Christopher J; Haessler, Jeffrey; Hall, Per; Haller, Toomas; Hallmans, Goran; Hannemann, Anke; Hartman, Catharina A; Hassinen, Maija; Hayward, Caroline; Heard-Costa, Nancy L; Helmer, Quinta; Hemani, Gibran; Henders, Anjali K; Hillege, Hans L; Hlatky, Mark A; Hoffmann, Wolfgang; Hoffmann, Per; Holmen, Oddgeir; Houwing-Duistermaat, Jeanine J; Illig, Thomas; Isaacs, Aaron; James, Alan L; Jeff, Janina; Johansen, Berit; Johansson, Åsa; Jolley, Jennifer; Juliusdottir, Thorhildur; Junttila, Juhani; Kho, Abel N; Kinnunen, Leena; Klopp, Norman; Kocher, Thomas; Kratzer, Wolfgang; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Lu, Yingchang; Lyssenko, Valeriya; Magnusson, Patrik K E; Mahajan, Anubha; Maillard, Marc; McArdle, Wendy L; McKenzie, Colin A; McLachlan, Stela; McLaren, Paul J; Menni, Cristina; Merger, Sigrun; Milani, Lili; Moayyeri, Alireza; Monda, Keri L; Morken, Mario A; Müller, Gabriele; Müller-Nurasyid, Martina; Musk, Arthur W; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M; Nöthen, Markus M; Oozageer, Laticia; Pilz, Stefan; Rayner, Nigel W; Renstrom, Frida; Robertson, Neil R; Rose, Lynda M; Roussel, Ronan; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Schumacher, Fredrick R; Schunkert, Heribert; Scott, Robert A; Sehmi, Joban; Seufferlein, Thomas; Shi, Jianxin; Silventoinen, Karri; Smit, Johannes H; Smith, Albert Vernon; Smolonska, Joanna; Stanton, Alice V; Stirrups, Kathleen; Stott, David J; Stringham, Heather M; Sundström, Johan; Swertz, Morris A; Syvänen, Ann-Christine; Tayo, Bamidele O; Thorleifsson, Gudmar; Tyrer, Jonathan P; van Dijk, Suzanne; van Schoor, Natasja M; van der Velde, Nathalie; van Heemst, Diana; van Oort, Floor V A; Vermeulen, Sita H; Verweij, Niek; Vonk, Judith M; Waite, Lindsay L; Waldenberger, Melanie; Wennauer, Roman; Wilkens, Lynne R; Willenborg, Christina; Wilsgaard, Tom; Wojczynski, Mary K; Wong, Andrew; Wright, Alan F; Zhang, Qunyuan; Arveiler, Dominique; Bakker, Stephan J L; Beilby, John; Bergman, Richard N; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boomsma, Dorret I; Bornstein, Stefan R; Bovet, Pascal; Brambilla, Paolo; Brown, Morris J; Campbell, Harry; Caulfield, Mark J; Chakravarti, Aravinda; Collins, Rory; Collins, Francis S; Crawford, Dana C; Cupples, L Adrienne; Danesh, John; de Faire, Ulf; den Ruijter, Hester M; Erbel, Raimund; Erdmann, Jeanette; Eriksson, Johan G; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Ford, Ian; Forouhi, Nita G; Forrester, Terrence; Gansevoort, Ron T; Gejman, Pablo V; Gieger, Christian; Golay, Alain; Gottesman, Omri; Gudnason, Vilmundur; Gyllensten, Ulf; Haas, David W; Hall, Alistair S; Harris, Tamara B; Hattersley, Andrew T; Heath, Andrew C; Hengstenberg, Christian; Hicks, Andrew A; Hindorff, Lucia A; Hingorani, Aroon D; Hofman, Albert; Hovingh, G Kees; Humphries, Steve E; Hunt, Steven C; Hypponen, Elina; Jacobs, Kevin B; Jarvelin, Marjo-Riitta; Jousilahti, Pekka; Jula, Antti M; Kaprio, Jaakko; Kastelein, John J P; Kayser, Manfred; Kee, Frank; Keinanen-Kiukaanniemi, Sirkka M; Kiemeney, Lambertus A; Kooner, Jaspal S; Kooperberg, Charles; Koskinen, Seppo; Kovacs, Peter; Kraja, Aldi T; Kumari, Meena; Kuusisto, Johanna; Lakka, Timo A; Langenberg, Claudia; Le Marchand, Loic; Lehtimäki, Terho; Lupoli, Sara; Madden, Pamela A F; Männistö, Satu; Manunta, Paolo; Marette, André; Matise, Tara C; McKnight, Barbara; Meitinger, Thomas; Moll, Frans L; Montgomery, Grant W; Morris, Andrew D; Morris, Andrew P; Murray, Jeffrey C; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J; Ong, Ken K; Ouwehand, Willem H; Pasterkamp, Gerard; Peters, Annette; Pramstaller, Peter P; Price, Jackie F; Qi, Lu; Raitakari, Olli T; Rankinen, Tuomo; Rao, D C; Rice, Treva K; Ritchie, Marylyn; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J; Saramies, Jouko; Sarzynski, Mark A; Schwarz, Peter E H; Sebert, Sylvain; Sever, Peter; Shuldiner, Alan R; Sinisalo, Juha; Steinthorsdottir, Valgerdur; Stolk, Ronald P; Tardif, Jean-Claude; Tönjes, Anke; Tremblay, Angelo; Tremoli, Elena; Virtamo, Jarmo; Vohl, Marie-Claude; Amouyel, Philippe; Asselbergs, Folkert W; Assimes, Themistocles L; Bochud, Murielle; Boehm, Bernhard O; Boerwinkle, Eric; Bottinger, Erwin P; Bouchard, Claude; Cauchi, Stéphane; Chambers, John C; Chanock, Stephen J; Cooper, Richard S; de Bakker, Paul I W; Dedoussis, George; Ferrucci, Luigi; Franks, Paul W; Froguel, Philippe; Groop, Leif C; Haiman, Christopher A; Hamsten, Anders; Hayes, M Geoffrey; Hui, Jennie; Hunter, David J; Hveem, Kristian; Jukema, J Wouter; Kaplan, Robert C; Kivimaki, Mika; Kuh, Diana; Laakso, Markku; Liu, Yongmei; Martin, Nicholas G; März, Winfried; Melbye, Mads; Moebus, Susanne; Munroe, Patricia B; Njølstad, Inger; Oostra, Ben A; Palmer, Colin N A; Pedersen, Nancy L; Perola, Markus; Pérusse, Louis; Peters, Ulrike; Powell, Joseph E; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Reinmaa, Eva; Ridker, Paul M; Rivadeneira, Fernando; Rotter, Jerome I; Saaristo, Timo E; Saleheen, Danish; Schlessinger, David; Slagboom, P Eline; Snieder, Harold; Spector, Tim D; Strauch, Konstantin; Stumvoll, Michael; Tuomilehto, Jaakko; Uusitupa, Matti; van der Harst, Pim; Völzke, Henry; Walker, Mark; Wareham, Nicholas J; Watkins, Hugh; Wichmann, H-Erich; Wilson, James F; Zanen, Pieter; Deloukas, Panos; Heid, Iris M; Lindgren, Cecilia M; Mohlke, Karen L; Speliotes, Elizabeth K; Thorsteinsdottir, Unnur; Barroso, Inês; Fox, Caroline S; North, Kari E; Strachan, David P; Beckmann, Jacques S; Berndt, Sonja I; Boehnke, Michael; Borecki, Ingrid B; McCarthy, Mark I; Metspalu, Andres; Stefansson, Kari; Uitterlinden, André G; van Duijn, Cornelia M; Franke, Lude; Willer, Cristen J; Price, Alkes L; Lettre, Guillaume; Loos, Ruth J F; Weedon, Michael N; Ingelsson, Erik; O'Connell, Jeffrey R; Abecasis, Goncalo R; Chasman, Daniel I; Goddard, Michael E; Visscher, Peter M; Hirschhorn, Joel N; Frayling, Timothy M

    2014-11-01

    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

  5. Defining the role of common variation in the genomic and biological architecture of adult human height

    PubMed Central

    Chu, Audrey Y; Estrada, Karol; Luan, Jian’an; Kutalik, Zoltán; Amin, Najaf; Buchkovich, Martin L; Croteau-Chonka, Damien C; Day, Felix R; Duan, Yanan; Fall, Tove; Fehrmann, Rudolf; Ferreira, Teresa; Jackson, Anne U; Karjalainen, Juha; Lo, Ken Sin; Locke, Adam E; Mägi, Reedik; Mihailov, Evelin; Porcu, Eleonora; Randall, Joshua C; Scherag, André; Vinkhuyzen, Anna AE; Westra, Harm-Jan; Winkler, Thomas W; Workalemahu, Tsegaselassie; Zhao, Jing Hua; Absher, Devin; Albrecht, Eva; Anderson, Denise; Baron, Jeffrey; Beekman, Marian; Demirkan, Ayse; Ehret, Georg B; Feenstra, Bjarke; Feitosa, Mary F; Fischer, Krista; Fraser, Ross M; Goel, Anuj; Gong, Jian; Justice, Anne E; Kanoni, Stavroula; Kleber, Marcus E; Kristiansson, Kati; Lim, Unhee; Lotay, Vaneet; Lui, Julian C; Mangino, Massimo; Leach, Irene Mateo; Medina-Gomez, Carolina; Nalls, Michael A; Nyholt, Dale R; Palmer, Cameron D; Pasko, Dorota; Pechlivanis, Sonali; Prokopenko, Inga; Ried, Janina S; Ripke, Stephan; Shungin, Dmitry; Stancáková, Alena; Strawbridge, Rona J; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W; van Setten, Jessica; Van Vliet-Ostaptchouk, Jana V; Wang, Zhaoming; Yengo, Loïc; Zhang, Weihua; Afzal, Uzma; Ärnlöv, Johan; Arscott, Gillian M; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J; Berne, Christian; Blüher, Matthias; Bolton, Jennifer L; Böttcher, Yvonne; Boyd, Heather A; Bruinenberg, Marcel; Buckley, Brendan M; Buyske, Steven; Caspersen, Ida H; Chines, Peter S; Clarke, Robert; Claudi-Boehm, Simone; Cooper, Matthew; Daw, E Warwick; De Jong, Pim A; Deelen, Joris; Delgado, Graciela; Denny, Josh C; Dhonukshe-Rutten, Rosalie; Dimitriou, Maria; Doney, Alex SF; Dörr, Marcus; Eklund, Niina; Eury, Elodie; Folkersen, Lasse; Garcia, Melissa E; Geller, Frank; Giedraitis, Vilmantas; Go, Alan S; Grallert, Harald; Grammer, Tanja B; Gräßler, Jürgen; Grönberg, Henrik; de Groot, Lisette C.P.G.M.; Groves, Christopher J; Haessler, Jeffrey; Hall, Per; Haller, Toomas; Hallmans, Goran; Hannemann, Anke; Hartman, Catharina A; Hassinen, Maija; Hayward, Caroline; Heard-Costa, Nancy L; Helmer, Quinta; Hemani, Gibran; Henders, Anjali K; Hillege, Hans L; Hlatky, Mark A; Hoffmann, Wolfgang; Hoffmann, Per; Holmen, Oddgeir; Houwing-Duistermaat, Jeanine J; Illig, Thomas; Isaacs, Aaron; James, Alan L; Jeff, Janina; Johansen, Berit; Johansson, Åsa; Jolley, Jennifer; Juliusdottir, Thorhildur; Junttila, Juhani; Kho, Abel N; Kinnunen, Leena; Klopp, Norman; Kocher, Thomas; Kratzer, Wolfgang; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Lu, Yingchang; Lyssenko, Valeriya; Magnusson, Patrik KE; Mahajan, Anubha; Maillard, Marc; McArdle, Wendy L; McKenzie, Colin A; McLachlan, Stela; McLaren, Paul J; Menni, Cristina; Merger, Sigrun; Milani, Lili; Moayyeri, Alireza; Monda, Keri L; Morken, Mario A; Müller, Gabriele; Müller-Nurasyid, Martina; Musk, Arthur W; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M; Nöthen, Markus M; Oozageer, Laticia; Pilz, Stefan; Rayner, Nigel W; Renstrom, Frida; Robertson, Neil R; Rose, Lynda M; Roussel, Ronan; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Schumacher, Fredrick R; Schunkert, Heribert; Scott, Robert A; Sehmi, Joban; Seufferlein, Thomas; Shi, Jianxin; Silventoinen, Karri; Smit, Johannes H; Smith, Albert Vernon; Smolonska, Joanna; Stanton, Alice V; Stirrups, Kathleen; Stott, David J; Stringham, Heather M; Sundström, Johan; Swertz, Morris A; Syvänen, Ann-Christine; Tayo, Bamidele O; Thorleifsson, Gudmar; Tyrer, Jonathan P; van Dijk, Suzanne; van Schoor, Natasja M; van der Velde, Nathalie; van Heemst, Diana; van Oort, Floor VA; Vermeulen, Sita H; Verweij, Niek; Vonk, Judith M; Waite, Lindsay L; Waldenberger, Melanie; Wennauer, Roman; Wilkens, Lynne R; Willenborg, Christina; Wilsgaard, Tom; Wojczynski, Mary K; Wong, Andrew; Wright, Alan F; Zhang, Qunyuan; Arveiler, Dominique; Bakker, Stephan JL; Beilby, John; Bergman, Richard N; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boomsma, Dorret I; Bornstein, Stefan R; Bovet, Pascal; Brambilla, Paolo; Brown, Morris J; Campbell, Harry; Caulfield, Mark J; Chakravarti, Aravinda; Collins, Rory; Collins, Francis S; Crawford, Dana C; Cupples, L Adrienne; Danesh, John; de Faire, Ulf; den Ruijter, Hester M; Erbel, Raimund; Erdmann, Jeanette; Eriksson, Johan G; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Ford, Ian; Forouhi, Nita G; Forrester, Terrence; Gansevoort, Ron T; Gejman, Pablo V; Gieger, Christian; Golay, Alain; Gottesman, Omri; Gudnason, Vilmundur; Gyllensten, Ulf; Haas, David W; Hall, Alistair S; Harris, Tamara B; Hattersley, Andrew T; Heath, Andrew C; Hengstenberg, Christian; Hicks, Andrew A; Hindorff, Lucia A; Hingorani, Aroon D; Hofman, Albert; Hovingh, G Kees; Humphries, Steve E; Hunt, Steven C; Hypponen, Elina; Jacobs, Kevin B; Jarvelin, Marjo-Riitta; Jousilahti, Pekka; Jula, Antti M; Kaprio, Jaakko; Kastelein, John JP; Kayser, Manfred; Kee, Frank; Keinanen-Kiukaanniemi, Sirkka M; Kiemeney, Lambertus A; Kooner, Jaspal S; Kooperberg, Charles; Koskinen, Seppo; Kovacs, Peter; Kraja, Aldi T; Kumari, Meena; Kuusisto, Johanna; Lakka, Timo A; Langenberg, Claudia; Le Marchand, Loic; Lehtimäki, Terho; Lupoli, Sara; Madden, Pamela AF; Männistö, Satu; Manunta, Paolo; Marette, André; Matise, Tara C; McKnight, Barbara; Meitinger, Thomas; Moll, Frans L; Montgomery, Grant W; Morris, Andrew D; Morris, Andrew P; Murray, Jeffrey C; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J; Ong, Ken K; Ouwehand, Willem H; Pasterkamp, Gerard; Peters, Annette; Pramstaller, Peter P; Price, Jackie F; Qi, Lu; Raitakari, Olli T; Rankinen, Tuomo; Rao, DC; Rice, Treva K; Ritchie, Marylyn; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J; Saramies, Jouko; Sarzynski, Mark A; Schwarz, Peter EH; Sebert, Sylvain; Sever, Peter; Shuldiner, Alan R; Sinisalo, Juha; Steinthorsdottir, Valgerdur; Stolk, Ronald P; Tardif, Jean-Claude; Tönjes, Anke; Tremblay, Angelo; Tremoli, Elena; Virtamo, Jarmo; Vohl, Marie-Claude; Amouyel, Philippe; Asselbergs, Folkert W; Assimes, Themistocles L; Bochud, Murielle; Boehm, Bernhard O; Boerwinkle, Eric; Bottinger, Erwin P; Bouchard, Claude; Cauchi, Stéphane; Chambers, John C; Chanock, Stephen J; Cooper, Richard S; de Bakker, Paul IW; Dedoussis, George; Ferrucci, Luigi; Franks, Paul W; Froguel, Philippe; Groop, Leif C; Haiman, Christopher A; Hamsten, Anders; Hayes, M Geoffrey; Hui, Jennie; Hunter, David J.; Hveem, Kristian; Jukema, J Wouter; Kaplan, Robert C; Kivimaki, Mika; Kuh, Diana; Laakso, Markku; Liu, Yongmei; Martin, Nicholas G; März, Winfried; Melbye, Mads; Moebus, Susanne; Munroe, Patricia B; Njølstad, Inger; Oostra, Ben A; Palmer, Colin NA; Pedersen, Nancy L; Perola, Markus; Pérusse, Louis; Peters, Ulrike; Powell, Joseph E; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Reinmaa, Eva; Ridker, Paul M; Rivadeneira, Fernando; Rotter, Jerome I; Saaristo, Timo E; Saleheen, Danish; Schlessinger, David; Slagboom, P Eline; Snieder, Harold; Spector, Tim D; Strauch, Konstantin; Stumvoll, Michael; Tuomilehto, Jaakko; Uusitupa, Matti; van der Harst, Pim; Völzke, Henry; Walker, Mark; Wareham, Nicholas J; Watkins, Hugh; Wichmann, H-Erich; Wilson, James F; Zanen, Pieter; Deloukas, Panos; Heid, Iris M; Lindgren, Cecilia M; Mohlke, Karen L; Speliotes, Elizabeth K; Thorsteinsdottir, Unnur; Barroso, Inês; Fox, Caroline S; North, Kari E; Strachan, David P; Beckmann, Jacques S.; Berndt, Sonja I; Boehnke, Michael; Borecki, Ingrid B; McCarthy, Mark I; Metspalu, Andres; Stefansson, Kari; Uitterlinden, André G; van Duijn, Cornelia M; Franke, Lude; Willer, Cristen J; Price, Alkes L.; Lettre, Guillaume; Loos, Ruth JF; Weedon, Michael N; Ingelsson, Erik; O’Connell, Jeffrey R; Abecasis, Goncalo R; Chasman, Daniel I; Goddard, Michael E

    2014-01-01

    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explain one-fifth of heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured the majority (60%) of heritability. The 697 variants clustered in 423 loci enriched for genes, pathways, and tissue-types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin, and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants. PMID:25282103

  6. Expression of small leucine-rich proteoglycans in rat anterior pituitary gland.

    PubMed

    Horiguchi, Kotaro; Syaidah, Rahimi; Fujiwara, Ken; Tsukada, Takehiro; Ramadhani, Dini; Jindatip, Depicha; Kikuchi, Motoshi; Yashiro, Takashi

    2013-01-01

    Proteoglycans are components of the extracellular matrix and comprise a specific core protein substituted with covalently linked glycosaminoglycan chains. Small leucine-rich proteoglycans (SLRPs) are a major family of proteoglycans and have key roles as potent effectors in cellular signaling pathways. Research during the last two decades has shown that SLRPs regulate biological functions in many tissues such as skin, tendon, kidney, liver, and heart. However, little is known of the expression of SLRPs, or the characteristics of the cells that produce them, in the anterior pituitary gland. Therefore, we have determined whether SLRPs are present in rat anterior pituitary gland. We have used real-time reverse transcription with the polymerase chain reaction to analyze the expression of SLRP genes and have identified the cells that produce SLRPs by using in situ hybridization with a digoxigenin-labeled cRNA probe. We have clearly detected the mRNA expression of SLRP genes, and cells expressing decorin, biglycan, fibromodulin, lumican, proline/arginine-rich end leucine-rich repeat protein (PRELP), and osteoglycin are located in the anterior pituitary gland. We have also investigated the possible double-staining of SLRP mRNA and pituitary hormones, S100 protein (a marker of folliculostellate cells), desmin (a marker of capillary pericytes), and isolectin B4 (a marker of endothelial cells). Decorin, biglycan, fibromodulin, lumican, PRELP, and osteoglycin mRNA have been identified in S100-protein-positive and desmin-positive cells. Thus, we conclude that folliculostellate cells and pericytes produce SLRPs in rat anterior pituitary gland.

  7. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.

    PubMed

    Fu, Binqing; Zhou, Yonggang; Ni, Xiang; Tong, Xianhong; Xu, Xiuxiu; Dong, Zhongjun; Sun, Rui; Tian, Zhigang; Wei, Haiming

    2017-12-19

    Natural killer (NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. However, the role of NK cells in fetal growth is unclear. Here, we have identified a CD49a + Eomes + subset of NK cells that secreted growth-promoting factors (GPFs), including pleiotrophin and osteoglycin, in both humans and mice. The crosstalk between HLA-G and ILT2 served as a stimulus for GPF-secreting function of this NK cell subset. Decreases in this GPF-secreting NK cell subset impaired fetal development, resulting in fetal growth restriction. The transcription factor Nfil3, but not T-bet, affected the function and the number of this decidual NK cell subset. Adoptive transfer of induced CD49a + Eomes + NK cells reversed impaired fetal growth and rebuilt an appropriate local microenvironment. These findings reveal properties of NK cells in promoting fetal growth. In addition, this research proposes approaches for therapeutic administration of NK cells in order to reverse restricted nourishments within the uterine microenvironment during early pregnancy. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Dynamics of zebrafish fin regeneration using a pulsed SILAC approach.

    PubMed

    Nolte, Hendrik; Hölper, Soraya; Housley, Michael P; Islam, Shariful; Piller, Tanja; Konzer, Anne; Stainier, Didier Y R; Braun, Thomas; Krüger, Marcus

    2015-02-01

    The zebrafish owns remarkable regenerative capacities allowing regeneration of several tissues, including the heart, liver, and brain. To identify protein dynamics during fin regeneration we used a pulsed SILAC approach that enabled us to detect the incorporation of (13) C6 -lysine (Lys6) into newly synthesized proteins. Samples were taken at four different time points from noninjured and regrowing fins and incorporation rates were monitored using a combination of single-shot 4-h gradients and high-resolution tandem MS. We identified more than 5000 labeled proteins during the first 3 weeks of fin regeneration and were able to monitor proteins that are responsible for initializing and restoring the shape of these appendages. The comparison of Lys6 incorporation rates between noninjured and regrowing fins enabled us to identify proteins that are directly involved in regeneration. For example, we observed increased incorporation rates of two actinodin family members at the actinotrichia, which is a hairlike fiber structure at the tip of regrowing fins. Moreover, we used quantitative real-time RNA measurements of several candidate genes, including osteoglycin, si:ch211-288h17.3, and prostaglandin reductase 1 to correlate the mRNA expression to Lys6 incorporation data. This novel pulsed SILAC methodology in fish can be used as a versatile tool to monitor newly synthesized proteins and will help to characterize protein dynamics during regenerative processes in zebrafish beyond fin regeneration. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Small leucine-rich repeat proteoglycans associated with mature insoluble elastin serve as binding sites for galectins.

    PubMed

    Itoh, Aiko; Nonaka, Yasuhiro; Ogawa, Takashi; Nakamura, Takanori; Nishi, Nozomu

    2017-11-01

    We previously reported that galectin-9 (Gal-9), an immunomodulatory animal lectin, could bind to insoluble collagen preparations and exerted direct cytocidal effects on immune cells. In the present study, we found that mature insoluble elastin is capable of binding Gal-9 and other members of the human galectin family. Lectin blot analysis of a series of commercial water-soluble elastin preparations, PES-(A) ~ PES-(E), revealed that only PES-(E) contained substances recognized by Gal-9. Gal-9-interacting substances in PES-(E) were affinity-purified, digested with trypsin and then analyzed by reversed-phase HPLC. Peptide fragments derived from five members of the small leucine-rich repeat proteoglycan family, versican, lumican, osteoglycin/mimecan, prolargin, and fibromodulin, were identified by N-terminal amino acid sequence analysis. The results indicate that Gal-9 and possibly other galectins recognize glycans attached to small leucine-rich repeat proteoglycans associated with insoluble elastin and also indicate the possibility that mature insoluble elastin serves as an extracellular reservoir for galectins.

  10. Decorin is a Zn(2+) Metalloprotein

    NASA Technical Reports Server (NTRS)

    Yang, Vivian W.-C.; LaBrenz, Steven R.; Rosenberg, Lawrence C.; McQuillan, David; Hoeoek, Magnus

    1998-01-01

    Decorin is ubiquitously distributed in the extracellular matrix of mammals and a member of the proteoglycan family characterized by a core protein dominated by Leucine Rich Repeat motifs. We here demonstrate that decorin extracted from bovine tissues under denaturing conditions or produced in recombinant "native" form by cultured mammalian cells, has a high affinity for Zn(2+). Binding of Zn(2+) to decorin is demonstrated by Zn(2+) chelating chromatography and equilibrium dialyses. The Zn(2+) binding sites are localized to the N-terminal domain of the core protein that contains 4 Cys residues in the spacing reminiscent of a Zn finger. A recombinant 41 amino acid long peptide representing the N-terminal domain of decorin has full Zn(2+) binding activity and binds two Zn(2+) ions with an average K(D) of 3 x 10(exp -7) M. Biglycan, a proteoglycan that is structurally closely related to decorin contains a similar high affinity Zn(2+) binding segment, whereas the structurally more distantly related proteoglycans, epiphycan and osteoglycin, did not bind Zn(2+) with high affinity.

  11. Characterisation of Bone Beneficial Components from Australian Wallaby Bone

    PubMed Central

    Lao, Weiguo; Jin, Xingliang; Tan, Yi; Xiao, Linda; Padula, Matthew P.; Bishop, David P.; Reedy, Brian; Ong, Madeleine; Kamal, Mohammad A.; Qu, Xianqin

    2016-01-01

    Background: Osteoporosis is a condition in which the bones become brittle, increasing the risk of fractures. Complementary medicines have traditionally used animal bones for managing bone disorders, such as osteoporosis. This study aimed to discover new natural products for these types of conditions by determining mineral and protein content of bone extracts derived from the Australian wallaby. Methods: Inductively coupled plasma-mass spectrometry and Fourier transform infrared spectroscopic analysis were used for mineral tests, proteome analysis was using LC/MS/MS and the effects of wallaby bone extracts (WBE)s on calcium deposition and alkaline phosphatase activity were evaluated in osteogenic cells derived from adipose tissue-derived stem cells (ADSCs). Results: Concentrations of calcium and phosphorus were 26.21% and 14.72% in WBE respectively. Additionally, minerals found were wide in variety and high in concentration, while heavy metal concentrations of aluminium, iron, zinc and other elements were at safe levels for human consumption. Proteome analysis showed that extracts contained high amounts of bone remodelling proteins, such as osteomodulin, osteopontin and osteoglycin. Furthermore, in vitro evaluation of WBEs showed increased deposition of calcium in osteoblasts with enhanced alkaline phosphatase activity in differentiated adipose-derived stem cells. Conclusion: Our results demonstrate that wallaby bone extracts possess proteins and minerals beneficial for bone metabolism. WBEs may therefore be used for developing natural products for conditions such as osteoporosis and further investigation to understand biomolecular mechanism by which WBEs prevent osteoporosis is warranted. PMID:28930133

  12. The effect of shock wave therapy on gene expression in human osteoblasts isolated from hypertrophic fracture non-unions

    NASA Astrophysics Data System (ADS)

    Hofmann, A.; Ritz, U.; Rompe, J.-D.; Tresch, A.; Rommens, P. M.

    2015-01-01

    Shock wave therapy has been increasingly evaluated as a non-invasive alternative for the treatment of delayed fracture healing and non-unions. Although several clinical studies showed a beneficial effect especially for the hypertrophic type of non-union, little is known about the biological mechanism of its osteogenic effect. To identify the molecular background for the positive effect of shock waves on healing of fracture non-unions, we have analyzed the changes of the global gene expression in human osteoblasts after exposure to shock waves of different energy flux densities. Human osteoblasts were isolated from five patients at non-union sites, treated with 500 impulses of energy flux densities of 0.06 and , and cultured for 96 h. HG-U133A microarrays were used for the analysis of the shock wave-regulated mRNA-transcripts. Differential gene expression was verified by reverse transcriptase polymerase chain reactions. We identified 47 transcripts that showed differential expression after and 45 transcripts after energy treatment. Most intriguing was the up-regulation of neprilysin, calmegin, osteoglycin, asporin, and interleukin-13 receptor-. Eighteen identified genes were previously described to fulfill an important function in bone growth and metabolism. Our study provides the first molecular profile of shock wave-induced gene expression changes in human osteoblasts from patients with hypertrophic fracture non-unions, and it offers a possible molecular explanation for the positive effects of shock waves in patients ridden with this disease.

  13. Simulated Microgravity Regulates Gene Transcript Profiles of 2T3 Preosteoblasts: Comparison of the Random Positioning Machine and the Rotating Wall Vessel Bioreactor

    NASA Technical Reports Server (NTRS)

    Patel, Mamta J.; Liu, Wenbin; Sykes, Michelle C.; Ward, Nancy E.; Risin, Semyon A.; Risin, Diana; Hanjoong, Jo

    2007-01-01

    Microgravity of spaceflight induces bone loss due in part to decreased bone formation by osteoblasts. We have previously examined the microgravity-induced changes in gene expression profiles in 2T3 preosteoblasts using the Random Positioning Machine (RPM) to simulate microgravity conditions. Here, we hypothesized that exposure of preosteoblasts to an independent microgravity simulator, the Rotating Wall Vessel (RWV), induces similar changes in differentiation and gene transcript profiles, resulting in a more confined list of gravi-sensitive genes that may play a role in bone formation. In comparison to static 1g controls, exposure of 2T3 cells to RWV for 3 days inhibited alkaline phosphatase activity, a marker of differentiation, and downregulated 61 genes and upregulated 45 genes by more than two-fold as shown by microarray analysis. The microarray results were confirmed with real time PCR for downregulated genes osteomodulin, bone morphogenic protein 4 (BMP4), runx2, and parathyroid hormone receptor 1. Western blot analysis validated the expression of three downregulated genes, BMP4, peroxiredoxin IV, and osteoglycin, and one upregulated gene peroxiredoxin I. Comparison of the microarrays from the RPM and the RWV studies identified 14 gravi-sensitive genes that changed in the same direction in both systems. Further comparison of our results to a published database showing gene transcript profiles of mechanically loaded mouse tibiae revealed 16 genes upregulated by the loading that were shown to be downregulated by RWV and RPM. These mechanosensitive genes identified by the comparative studies may provide novel insights into understanding the mechanisms regulating bone formation and potential targets of countermeasure against decreased bone formation both in astronauts and in general patients with musculoskeletal disorders.

  14. Privacy and social implications of distinct sensing approaches to implementing smart homes for older adults.

    PubMed

    Demiris, George

    2009-01-01

    Two distinct approaches to smart home design, namely Distributed Direct Sensing (DDS) and Infrastructure Mediated Sensing (IMS), have distinguishing features and implications resulting from their implementation. These two distinct smart home approaches have not been directly compared pertaining to their technical performance or their acceptance by the end users. It is also unclear what the perceived privacy and obtrusiveness concerns are when it comes to the implementation of these two different approaches in homes. The study presented here aimed to evaluate acceptance of these two sensing approaches by older adults and assess the perceived privacy and obtrusiveness concerns and ultimately define their social implications.

  15. Assessing Threats of School Violence: Implications for Counselors

    ERIC Educational Resources Information Center

    Daniels, Jeffrey A.

    2002-01-01

    The author describes important considerations when assessing students' threats made at schools. In a recent article, M. Reddy et al. (2001) presented 4 approaches to assessing the risk of school violence. They submitted important issues and problems with 3 commonly used approaches and suggested a 4th approach as an alternative. Implications for…

  16. Anger is an approach-related affect: evidence and implications.

    PubMed

    Carver, Charles S; Harmon-Jones, Eddie

    2009-03-01

    The authors review a range of evidence concerning the motivational underpinnings of anger as an affect, with particular reference to the relationship between anger and anxiety or fear. The evidence supports the view that anger relates to an appetitive or approach motivational system, whereas anxiety relates to an aversive or avoidance motivational system. This evidence appears to have 2 implications. One implication concerns the nature of anterior cortical asymmetry effects. The evidence suggests that such asymmetry reflects direction of motivational engagement (approach vs. withdrawal) rather than affective valence. The other implication concerns the idea that affects form a purely positive dimension and a purely negative dimension, which reflect the operation of appetitive and aversive motivational systems, respectively. The evidence reviewed does not support that view. The evidence is, however, consistent with a discrete-emotions view (which does not rely on dimensionality) and with an alternative dimensional approach. (c) 2009 APA, all rights reserved.

  17. World-View Entrapment: Moral-Ethical Implications for Gifted Education.

    ERIC Educational Resources Information Center

    Ambrose, Don

    2000-01-01

    This article explores the moral-ethical implications of the mechanistic world view and related issues such as technological determinism, social Darwinism, and androcentrism. It finds that educational approaches reinforced by the mechanistic world view include positivistic approaches to curriculum, instruction, and research. Recommendations for…

  18. Non-Traditional Education: Modalities and Implications for Higher Education.

    ERIC Educational Resources Information Center

    Ash, Barbara F.

    Nontraditional approaches in higher education are discussed, with attention to: (1) economic and philosophical reasons for nontraditional education; (2) future thrusts; (3) nontraditional instructional modalities; and (4) the implications for higher education of the extensive use of nontraditional approaches. It is suggested that nontraditional…

  19. My genes made me do it? The implications of behavioural genetics for responsibility and blame.

    PubMed

    Levitt, Mairi; Manson, Neil

    2007-03-01

    The idea of individual responsibility for action is central to our conception of what it is to be a person. Behavioural genetic research may seem to call into question the idea of individual responsibility with possible implications for the criminal justice system. These implications will depend on the understandings of the various agencies and professional groups involved in responding to violent and anti-social behaviour, and, the result of negotiations between them over resulting practice. The paper considers two kinds of approaches to the question of responsibility and 'criminal genes' arising from a sociological and philosophical perspective respectively. One is to consider the social context and possible practical implications of research into 'criminal genes' which will later be examined through interviews and discussions with a range of experts including lawyers and social workers. A second and different kind of approach is to ask whether the findings of behavioural genetics ought to have implications for attributions of responsibility. Issues of genetic influence are central to both approaches.

  20. Positively Influencing Gifted Education Policy

    ERIC Educational Resources Information Center

    Plucker, Jonathan A.

    2012-01-01

    The approach proposed by Subotnik, Olszewski-Kubilius, and Worrell (2011) has significant implications for the field of gifted education, many of which would increase advocates' ability to achieve success when working with policy makers. This commentary explores those implications and examines how the proposed approach can be integrated within the…

  1. Implications of Climate Change for State Bioassessment Programs and Approaches to Account for Effects (Final Report)

    EPA Science Inventory

    EPA announced the availability of the final report, Implications of Climate Change for State Bioassessment Programs and Approaches to Account for Effects. This report uses biological data collected by four states in wadeable rivers and streams to examine the components ...

  2. Human-Centered Systems Analysis of Aircraft Separation from Adverse Weather: Implications for Icing Remote Sensing

    NASA Technical Reports Server (NTRS)

    Vigeant-Langlois, Laurence; Hansman, R. John, Jr.

    2003-01-01

    The objective of this project was to propose a means to improve aviation weather information, training procedures based on a human-centered systems approach. Methodology: cognitive analysis of pilot's tasks; trajectory-based approach to weather information; contingency planning support; and implications for improving weather information.

  3. [MATCHE: Management Approach to Teaching Consumer and Homemaking Education.] Consumer Approach Strand: Textiles and Clothing. Module I-D-4: Applications and Implications of New Technology in Textiles and Clothing.

    ERIC Educational Resources Information Center

    Joseph, Marjory

    This competency-based preservice home economics teacher education module on applications and implications of new technology in textiles and clothing is the fourth in a set of four modules on consumer education related to textiles and clothing. (This set is part of a larger series of sixty-seven modules on the Management Approach to Teaching…

  4. An Enterprising Approach to Regional Growth: Implications for Policy and the Role of VET--Support Document

    ERIC Educational Resources Information Center

    Garlick, Steve; Taylor, Michael; Plummer, Paul

    2007-01-01

    "An Enterprising Approach to Regional Growth: Implications for Policy and the Role of Vocational Education and Training" explores patterns of regional economic growth in Australia over the period 1984 to 2002 with the aim of identifying the drivers of variation in regional growth; the research also aimed to identify regional…

  5. A Quantitative Corpus-Based Approach to English Spatial Particles: Conceptual Symmetry and Its Pedagogical Implications

    ERIC Educational Resources Information Center

    Chen, Alvin Cheng-Hsien

    2014-01-01

    The present study aims to investigate how conceptual symmetry plays a role in the use of spatial particles in English and to further examine its pedagogical implications via a corpus-based evaluation of the course books in senior high schools in Taiwan. More specifically, we adopt a quantitative corpus-based approach to investigate whether bipolar…

  6. An Intervention in Literacy in Three Pacific Nations: Implications of a Context Specific Approach to Co-Design

    ERIC Educational Resources Information Center

    Jesson, Rebecca N.; Spratt, Rebecca

    2017-01-01

    In this paper, we consider the implications of a commitment to acknowledging the role of context within a research practice partnership. We outline the approach to doing so within a design-based research intervention with 42 schools across three Pacific Island countries to improve literacy learning and language development. In doing so, the paper…

  7. Theory and Methodology in Researching Emotions in Education

    ERIC Educational Resources Information Center

    Zembylas, Michalinos

    2007-01-01

    Differing theoretical approaches to the study of emotions are presented: emotions as private (psychodynamic approaches); emotions as sociocultural phenomena (social constructionist approaches); and a third perspective (interactionist approaches) transcending these two. These approaches have important methodological implications in studying…

  8. Women at Midlife: Implications for Theories of Women's Adult Development.

    ERIC Educational Resources Information Center

    Lippert, Laurel

    1997-01-01

    Discusses research on midlife transitions in women and its implications for theories of women's adult development. Presents findings on menopause, the postparental period, and the roles of women at midlife. Offers several theoretical approaches in light of research findings and makes recommendations for future research. Suggests implications for…

  9. Acceptable health and priority weighting: Discussing a reference-level approach using sufficientarian reasoning.

    PubMed

    Wouters, S; van Exel, N J A; Rohde, K I M; Vromen, J J; Brouwer, W B F

    2017-05-01

    Health care systems are challenged in allocating scarce health care resources, which are typically insufficient to fulfil all health care wants and needs. One criterion for priority setting may be the 'acceptable health' approach, which suggests that society may want to assign higher priority to health benefits in people with "unacceptable" than in people with "acceptable" health. A level of acceptable health then serves as a reference point for priority setting. Empirical research has indicated that people may be able and willing to define health states as "unacceptable" or "acceptable", but little attention has been given to the normative implications of evaluating health benefits in relation to a reference level of acceptable health. The current paper aims to address this gap by relating insights from the distributive justice literature, i.e. the sufficientarian literature, to the acceptable health approach, as we argue that these approaches are related. We specifically focus on the implications of an 'acceptability' approach for priority weighting of health benefits, derived from sufficientarian reasoning and debates, and assess the moral implications of such weighting. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Bolzano`s Approach to the Paradoxes of Infinity: Implications for Teaching

    NASA Astrophysics Data System (ADS)

    Waldegg, Guillermina

    2005-08-01

    In this paper we analyze excerpts of Paradoxes of the Infinite, the posthumous work of Bernard Bolzano (1781-1848), in order to show that Georg Cantor‘s (1845-1918) approach to the problem of defining actual mathematical infinity is not the most natural. In fact, Bolzano‘s approach to the paradoxes of infinity is more intuitive, while remaining internally coherent. Bolzano‘s approach, however, had limitations. We discuss implications for teaching, which include a better understanding of the responses of students to situations involving actual mathematical infinity, for it is possible to draw a kind of parallel between these responses and Bolzano‘s reasoning.

  11. The stress-reward-mentalizing model of depression: An integrative developmental cascade approach to child and adolescent depressive disorder based on the research domain criteria (RDoC) approach.

    PubMed

    Luyten, Patrick; Fonagy, Peter

    2017-10-09

    The Research Domain Criteria (RDoC) propose a much-needed change in approach to the study of vulnerability factors implicated in mental disorders, shifting away from a categorical, disease-oriented model to a dimensional approach that focuses on underlying systems implicated in psychopathology. In this paper we illustrate this approach with a focus on the emergence of depression in childhood and adolescence. Based on evolutionary biological and developmental psychopathology considerations, we present an integrative developmental cascade model of depression that essentially suggests that depression emerges out of a three-pronged series of interacting impairments in the domains of stress regulation, reward, and mentalizing. We discuss the relation of these impairments to the five domains proposed by RDoC. We also focus on how this model may explain in large part the marked comorbidity of depression with other psychiatric disorders, as well as with functional somatic and somatic disorders. Limitations of this theoretical approach are discussed, as well as implications for the development, evaluation, and dissemination of interventions aimed at preventing or treating depression. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Education System Reform in China after 1978: Some Practical Implications

    ERIC Educational Resources Information Center

    Sun, Miantao

    2010-01-01

    Purpose: This paper aims to provide an overview of education system reform in China since 1978, and its practical implications. Design/methodology/approach: Data were collected from literature review and interview. An overview of education system reform and its practical implications was found through data analysis. Findings: There has been two…

  13. Annual Research Review: Categories versus Dimensions in the Classification and Conceptualisation of Child and Adolescent Mental Disorders--Implications of Recent Empirical Study

    ERIC Educational Resources Information Center

    Coghill, David; Sonuga-Barke, Edmund J. S.

    2012-01-01

    The question of whether child and adolescent mental disorders are best classified using dimensional or categorical approaches is a contentious one that has equally profound implications for clinical practice and scientific enquiry. Here, we explore this issue in the context of the forth coming publication of the DSM-5 and ICD-11 approaches to…

  14. Balancing the Direct and Indirect Approaches: Implications for Ending the Violence in Southern Thailand

    DTIC Science & Technology

    2009-12-01

    DIRECT AND INDIRECT APPROACHES: IMPLICATIONS FOR ENDING THE VIOLENCE IN SOUTHERN THAILAND by Chaiyo Rodthong December 2009 Thesis Advisor... Thailand 6. AUTHOR(S) Chaiyo Rodthong 5. FUNDING NUMBERS 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA...distribution is unlimited 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) The instability in the Southern Border Provinces of Thailand resurged on

  15. The impact of user- and system-initiated personalization on the user experience at large sports events.

    PubMed

    Sun, Xu; May, Andrew; Wang, Qingfeng

    2016-05-01

    This article describes an experimental study investigating the impact on user experience of two approaches of personalization of content provided on a mobile device, for spectators at large sports events. A lab-based experiment showed that a system-driven approach to personalization was generally preferable, but that there were advantages to retaining some user control over the process. Usability implications for a hybrid approach, and design implications are discussed, with general support for countermeasures designed to overcome recognised limitations of adaptive systems. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  16. When is success not satisfying? Integrating regulatory focus and approach/avoidance motivation theories to explain the relation between core self-evaluation and job satisfaction.

    PubMed

    Ferris, D Lance; Johnson, Russell E; Rosen, Christopher C; Djurdjevic, Emilija; Chang, Chu-Hsiang Daisy; Tan, James A

    2013-03-01

    Integrating implications from regulatory focus and approach/avoidance motivation theories, we present a framework wherein motivational orientations toward positive (approach motivation orientation) or negative (avoidance motivation orientation) stimuli interact with workplace success to mediate the relation of core self-evaluation (CSE) with job satisfaction. Using data collected from supervisor-subordinate dyads (Sample 1) and time-lagged data (Sample 2), we found that the results from two studies indicated that the interaction of workplace success and avoidance motivation orientation mediated relations of CSE with job satisfaction. Although approach motivation orientation did not interact with workplace success, it did mediate the CSE-job satisfaction relation on its own. Implications for the CSE and approach/avoidance literatures are discussed.

  17. Common Pediatric Disabilities: Medical Aspects and Educational Implications.

    ERIC Educational Resources Information Center

    Tyler, Janet Siantz; Colson, Steven

    1994-01-01

    This paper presents definitions of common pediatric disabilities and information about incidence, causes, diagnosis, common characteristics, complications with educational implications, and multidisciplinary intervention approaches. It covers the following conditions: attention deficit hyperactivity disorder, cerebral palsy, Down syndrome, fragile…

  18. Epistemological and Treatment Implications of Nonlinear Dynamics

    NASA Astrophysics Data System (ADS)

    Stein, A. H.

    The treatment implications of understanding mind as solely epiphenomenal to nonlinearly founded neurobiology are discussed. G. Klimovsky's epistemological understanding of psychoanalysis as a science is rejected and treatment approaches integrating W. R. Bion's and D. W. Winnicott's work are supported.

  19. THE NEIGHBORHOOD YOUTH CORPS AND THE COMMUNITY, AN EXPLORATORY STUDY OF THE IMPLICATIONS OF A FEDERAL ANTI-POVERTY PROGRAM FOR MILWAUKEE, WISCONSIN.

    ERIC Educational Resources Information Center

    CARO, FRANCIS G.

    TWO APPROACHES WERE USED IN STUDYING THE EFFECTS OF THE NEIGHBORHOOD YOUTH CORPS (NYC) ON MILWAUKEE, WISCONSIN -- (1) IMPLICATIONS FOR THE INTERNAL AND EXTERNAL OPERATIONS OF ORGANIZATIONS INVOLVED IN ITS WORK FLOW, AND (2) IMPLICATIONS FOR SPECIFIC PROBLEMS IN THE YOUTH AND POVERTY AREAS (SCHOOL ATTENDANCE AND ACHIEVEMENT, JUVENILE DELINQUENCY,…

  20. Modeling energy/economy interactions for conservation and renewable energy-policy analysis

    NASA Astrophysics Data System (ADS)

    Groncki, P. J.

    Energy policy and the implications for policy analysis and the methodological tools are discussed. The evolution of one methodological approach and the combined modeling system of the component models, their evolution in response to changing analytic needs, and the development of the integrated framework are reported. The analyses performed over the past several years are summarized. The current philosophy behind energy policy is discussed and compared to recent history. Implications for current policy analysis and methodological approaches are drawn.

  1. Robotics with Natural Language Comprehension and Learning Abilities.

    DTIC Science & Technology

    1985-01-01

    Artificial intellignece implications for knowledge retrivedO. Accession For NTIGRA&I DTIC TAB Unannounced 0 Justifioation *5**.By I Distribution...through understanding and generalizing plans", "An approach to learning from observation", and " Artificial intelligence implications for knowledge

  2. A Systems Approach to Diagnostic Prescriptive Instruction.

    ERIC Educational Resources Information Center

    Kozma, Robert B.; And Others

    This five-part document presents three approaches to research on instructional improvement, with the final two sections concentrating on problems and implications for diagnostic prescriptive instruction. Part 1 reviews comparative instructional effectiveness studies. Part 2 discusses the Trait-Treatment Interaction Approach (TTI) which is…

  3. Creativity Research: Implications for Teaching, Learning and Thinking.

    ERIC Educational Resources Information Center

    Petrowski, Mary Jane

    2000-01-01

    Explores reasons why creativity has only recently gained credibility as a legitimate research field and provides an overview of various disciplinary approaches and methodologies currently in use that are relevant to teaching and learning. Highlights include psychometrics; contextual approaches; experimental approaches; biographical, or…

  4. International System and Foreign Policy Approaches: Implications for Conflict Modelling and Management

    DTIC Science & Technology

    tool for conflict management , preliminary version of which is the Computer Aided Conflict Information System. Using expert judgments to describe...1961. The combined model is more relevant during the crisis phase. The results have implications for conflict modelling. With respect to conflict ... management , there is an important implication. Since the organizational processes model may be more valid than an event interaction model, then conflict

  5. The "Responsive Classroom" Approach and Its Implications for Improving Reading and Writing

    ERIC Educational Resources Information Center

    McTigue, Erin M.; Rimm-Kaufman, Sara E.

    2011-01-01

    This article describes a social and emotional learning intervention, the "Responsive Classroom"[R] (RC) approach, which is designed to produce classroom environments conducive to learning. It summarizes a new body of research describing the efficacy of the RC approach. One component of the RC approach is the Morning Meeting. This article…

  6. New Approaches to the Teaching of the Classics.

    ERIC Educational Resources Information Center

    Masciantonio, Rudolph, Ed.; Weislogel, Stephen, Ed.

    This four-part report of the 1971-72 Classical Association of the Atlantic States Working Committee deals with the rationale for new approaches and curriculums for schools and colleges. Implications of the new approaches in teacher education are also teated. The major section treating new model curriculums and approaches includes discussion of:…

  7. Four Approaches to Cultural Diversity: Implications for Teaching at Institutions of Higher Education.

    ERIC Educational Resources Information Center

    Ofori-Dankwa, Joseph; Lane, Robert W.

    2000-01-01

    Identifies four approaches to cultural diversity that professors at institutions of higher education may take. These are neutrality, similarity, diversity, and diversimilarity. Identifies the strengths and weaknesses of each of these approaches, and argues for the diversimilarity approach, using the teaching of the death penalty (and examination…

  8. Teaching Critical Thinking by Examining Assumptions

    ERIC Educational Resources Information Center

    Yanchar, Stephen C.; Slife, Brent D.

    2004-01-01

    We describe how instructors can integrate the critical thinking skill of examining theoretical assumptions (e.g., determinism and materialism) and implications into psychology courses. In this instructional approach, students formulate questions that help them identify assumptions and implications, use those questions to identify and examine the…

  9. Approaches to culture and diversity: A critical synthesis of occupational therapy literature.

    PubMed

    Beagan, Brenda L

    2015-12-01

    The 2007 position statement on diversity for the Canadian occupational therapy profession argued discussion was needed to determine the implications of approaches to working with cultural differences and other forms of diversity. In 2014, a new position statement on diversity was published, emphasizing the importance of social power relations and power relations between client and therapist, and supporting two particular approaches: cultural safety and cultural humility with critical reflexivity This paper reviews and critically synthesizes the literature concerning culture and diversity published in occupational therapy between 2007 and 2014, tracing the major discourses and mapping the implications of four differing approaches: cultural competence, cultural relevance, cultural safety, and cultural humility. Approaches differ in where they situate the "problem," how they envision change, the end goal, and the application to a range of types of diversity. The latter two are preferred approaches for their attention to power relations and potential to encompass a range of types of social and cultural diversity. © CAOT 2015.

  10. Social Models: Blueprints or Processes?

    ERIC Educational Resources Information Center

    Little, Graham R.

    1981-01-01

    Discusses the nature and implications of two different models for societal planning: (1) the problem-solving process approach based on Karl Popper; and (2) the goal-setting "blueprint" approach based on Karl Marx. (DC)

  11. Implications of the behavioral approach to hypnosis.

    PubMed

    Starker, S

    1975-07-01

    The findings of behaviorally oriented research regarding the importance of cognitive-motivational variables in hypnosis are examined and some clinical and theoretical implications are explored. Hypnosis seems usefully conceptualized as a complex configuration or gestalt of interacting variables on several different levels, for example, cognitive, motivational, social, physiologic.

  12. Medical Waste Management Implications for Small Medical Facilities.

    ERIC Educational Resources Information Center

    Byrns, George; Burke, Thomas

    1992-01-01

    Discusses the implications of the Medical Waste Management Act of 1988 for small medical facilities, public health, and the environment. Reviews health and environmental risks associated with medical waste, current regulatory approaches, and classifications. Concludes that the health risk of medical wastes has been overestimated; makes…

  13. ANTHROPOGENIC NUTRIENT INPUT AND ITS INFLUENCE ON PLANT COMPETITIVE OUTCOMES: IMPLICATIONS FOR HABITAT DEGRADATION AND COMMUNITY SHIFTS

    EPA Science Inventory

    By taking a multifactorial approach, the study will document complex aquatic plant responses to NPS nutrient contamination, providing fundamental insight into the broader impacts of environmental degradation, its impacts on plant function, and implications for ecosystem ser...

  14. A Discrete Approach to Computer-Oriented Calculus.

    ERIC Educational Resources Information Center

    Gordon, Sheldon P.

    1979-01-01

    Some of the implications and advantages of an instructional approach using results from the calculus of finite differences and finite sums, both for motivation and as tools leading to applications, are discussed. (MP)

  15. The Developmental Dialectical Approach to Child Abuse & Neglect.

    ERIC Educational Resources Information Center

    Pakizegi, B.

    A developmental dialectical approach to understanding and working with lower and middle class damaged parents--those identified as abusive and neglectful--has specific features and implications. The approach suggests that (1) the personality characteristics and interpersonal relations of parents are inseparable from their social conditions; (2)…

  16. Ethical Issues in International Communication: The Contribution of Research.

    ERIC Educational Resources Information Center

    Kent, Kurt E. M.

    Two approaches to communication research, diffusion theory (individual-level analysis) and empathy approach (action implications through society) raise ethical concerns. The popularity of the approaches is related to power: those, such as government agencies, who provide funding often reflect self-interest in project selection. Some ethical…

  17. An emerging paradigm: a strength-based approach to exploring mental imagery

    PubMed Central

    MacIntyre, Tadhg E.; Moran, Aidan P.; Collet, Christian; Guillot, Aymeric

    2013-01-01

    Mental imagery, or the ability to simulate in the mind information that is not currently perceived by the senses, has attracted considerable research interest in psychology since the early 1970's. Within the past two decades, research in this field—as in cognitive psychology more generally—has been dominated by neuroscientific methods that typically involve comparisons between imagery performance of participants from clinical populations with those who exhibit apparently normal cognitive functioning. Although this approach has been valuable in identifying key neural substrates of visual imagery, it has been less successful in understanding the possible mechanisms underlying another simulation process, namely, motor imagery or the mental rehearsal of actions without engaging in the actual movements involved. In order to address this oversight, a “strength-based” approach has been postulated which is concerned with understanding those on the high ability end of the imagery performance spectrum. Guided by the expert performance approach and principles of ecological validity, converging methods have the potential to enable imagery researchers to investigate the neural “signature” of elite performers, for example. Therefore, the purpose of this paper is to explain the origin, nature, and implications of the strength-based approach to mental imagery. Following a brief explanation of the background to this latter approach, we highlight some important theoretical advances yielded by recent research on mental practice, mental travel, and meta-imagery processes in expert athletes and dancers. Next, we consider the methodological implications of using a strength-based approach to investigate imagery processes. The implications for the field of motor cognition are outlined and specific research questions, in dynamic imagery, imagery perspective, measurement, multi-sensory imagery, and metacognition that may benefit from this approach in the future are sketched briefly. PMID:23554591

  18. Chaos Theory: Implications for Nonlinear Dynamics in Counseling.

    ERIC Educational Resources Information Center

    Stickel, Sue A.

    The purpose of this paper is to explore the implications of chaos theory for counseling. The scientific notion of chaos refers to the tendency of dynamical, nonlinear systems toward irregular, sometimes unpredictable, yet deterministic behavior. Therapists, especially those working from a brief approach, have noted the importance of the client's…

  19. Analytical Implications of Using Practice Theory in Workplace Information Literacy Research

    ERIC Educational Resources Information Center

    Moring, Camilla; Lloyd, Annemaree

    2013-01-01

    Introduction: This paper considers practice theory and the analytical implications of using this theoretical approach in information literacy research. More precisely the aim of the paper is to discuss the translation of practice theoretical assumptions into strategies that frame the analytical focus and interest when researching workplace…

  20. Steps to Successful Professional Development in Head Start

    ERIC Educational Resources Information Center

    Trivette, Carol M.; Raab, Melinda; Dunst, Carl J.

    2012-01-01

    This article discusses the implications of utilizing coaching-mentoring strategies with Head Start teachers identified from the results of a study which used an evidence-based approach to professional development. Early childhood and coaching practices that formed the basis of the study are explained. Implications from the study results regarding…

  1. People and Technology Today: Some Educational Implications

    ERIC Educational Resources Information Center

    Rodriguez-Sedano, Alfredo; Paris, Ana Costa; Mut, Maite Dassoy

    2011-01-01

    The present article approaches some of the educational implications borne by humanity with technological progress. We begin by pointing out significant data that classify what is considered relevant. Then, confronting the future is discussed by analyzing the attitudes necessary to promote the goals. Confronted with these challenges, three possible…

  2. The Relationship between Mathematical Induction, Proposition Functions, and Implication Functions

    ERIC Educational Resources Information Center

    Andrew, Lane

    2010-01-01

    In this study, I explored the relationship between mathematical induction ability and proposition and implication functions through a mixed methods approach. Students from three universities (N = 78) and 6 classrooms completed a written assessment testing their conceptual and procedural capabilities with induction and functions. In addition, I…

  3. Three Diagnostic Approaches to Asperger Syndrome: Implications for Research

    ERIC Educational Resources Information Center

    Klin, Ami; Pauls, David; Schultz, Robert; Volkmar, Fred

    2005-01-01

    Objective: To examine the implications for research of the use of three alternative definitions for Asperger syndrome (AS). Differences across the three nosologic systems were examined in terms of diagnostic assignment, IQ profiles, comorbid symptoms, and familial aggregation of social and other psychiatric symptoms. Method: Standard data on…

  4. Understanding Networking in China and the Arab World: Lessons for International Managers

    ERIC Educational Resources Information Center

    Hutchings, Kate; Weir, David

    2006-01-01

    Purpose: To explore the implications of internationalisation for "guanxi" and "wasta" and the role of trust, family and favours in underpinning these traditional models of networking. The paper also draws some implications for management development professionals and trainers. Design/methodology/approach: The argument is based…

  5. Financial Implications of Implementing an E-Learning Project

    ERIC Educational Resources Information Center

    Sharma, Kunal

    2011-01-01

    Purpose: This paper aims to outline the financial implications, while deploying information and communication technologies for implementing e-learning, and to elucidate them, while implementing an e-learning project in a conventional university environment. Design/methodology/approach: The paper is a descriptive account of the various cost factors…

  6. Veterinary Homeopathy: The Implications of Its History for Unorthodox Veterinary Concepts and Veterinary Medical Education.

    ERIC Educational Resources Information Center

    Coulter, Dwight B.

    1979-01-01

    The history of veterinary homeopathy, its future and implications are discussed. The need for investigation into the validity of both allopathic and homeopathic claims is stressed and it is suggested that maintenance of quality is the key factor in any approach. (BH)

  7. Continuous Improvement Framework: Implications for Academia

    ERIC Educational Resources Information Center

    Temponi, Cecilia

    2005-01-01

    Purpose: To analyze the main elements of continuous improvement (CI) in higher education and the concerns of academia's stakeholders in the implementation of such an approach. Suggests guidelines for the development of a culture more receptive to the implementation and maintenance of a CI approach in higher education. Design/methodology/approach:…

  8. Curriculum Approaches in Language Teaching: Forward, Central, and Backward Design

    ERIC Educational Resources Information Center

    Richards, Jack C.

    2013-01-01

    The development and implementation of language teaching programs can be approached in several different ways, each of which has different implications for curriculum design. Three curriculum approaches are described and compared. Each differs with respect to when issues related to input, process, and outcomes, are addressed. Forward design starts…

  9. Why Philosophical Ethics in School: Implications for Education in Technology and in General

    ERIC Educational Resources Information Center

    Gardelli, Viktor; Alerby, Eva; Persson, Anders

    2014-01-01

    In this article, we distinguish between three approaches to ethics in school, each giving an interpretation of the expression "ethics in school": the "descriptive facts about ethics approach," roughly consisting of teaching empirical facts about moral matters to students; the "moral fostering approach," consisting of…

  10. Comparing Team Learning Approaches through the Lens of Activity Theory

    ERIC Educational Resources Information Center

    Park, Sunyoung; Cho, Yonjoo; Yoon, Seung Won; Han, Heeyoung

    2013-01-01

    Purpose: The purpose of this study is to examine the distinctive features of three team learning approaches (action learning, problem-based learning, and project-based learning), compare and contrast them, and discuss implications for practice and research. Design/methodology/approach: The authors used Torraco's integrative literature review…

  11. External Validity in the Study of Human Development: Theoretical and Methodological Issues

    ERIC Educational Resources Information Center

    Hultsch, David F.; Hickey, Tom

    1978-01-01

    An examination of the concept of external validity from two theoretical perspectives: a traditional mechanistic approach and a dialectical organismic approach. Examines the theoretical and methodological implications of these perspectives. (BD)

  12. Building a quality culture in the Office of Space Flight: Approach, lessons learned and implications for the future

    NASA Astrophysics Data System (ADS)

    Roberts, C. Shannon

    The purpose of this paper is to describe the approach and lessons learned by the Office of Space Flight (OSF), National Aeronautics and Space Administration (NASA), in its introduction of quality. In particular, the experience of OSF Headquarters is discussed as an example of an organization within NASA that is considering both the business and human elements of the change and the opportunities the quality focus presents to improve continuously. It is hoped that the insights shared will be of use to those embarking upon similar cultural changes. The paper is presented in the following parts: the leadership challenge; background; context of the approach to quality; initial steps; current initiatives; lessons learned; and implications for the future.

  13. Building a quality culture in the Office of Space Flight: Approach, lessons learned and implications for the future

    NASA Technical Reports Server (NTRS)

    Roberts, C. Shannon

    1992-01-01

    The purpose of this paper is to describe the approach and lessons learned by the Office of Space Flight (OSF), National Aeronautics and Space Administration (NASA), in its introduction of quality. In particular, the experience of OSF Headquarters is discussed as an example of an organization within NASA that is considering both the business and human elements of the change and the opportunities the quality focus presents to improve continuously. It is hoped that the insights shared will be of use to those embarking upon similar cultural changes. The paper is presented in the following parts: the leadership challenge; background; context of the approach to quality; initial steps; current initiatives; lessons learned; and implications for the future.

  14. Further Conceptualizing Ethnic and Racial Identity Research: The Social Identity Approach and Its Dynamic Model.

    PubMed

    Verkuyten, Maykel

    2016-11-01

    This article proposes a further conceptualization of ethnic and racial identity (ERI) as a fundamental topic in developmental research. Adding to important recent efforts to conceptually integrate and synthesize this field, it is argued that ERI research will be enhanced by more fully considering the implications of the social identity approach. These implications include (a) the conceptualization of social identity, (b) the importance of identity motives, (c) systematic ways for theorizing and examining the critical role of situational and societal contexts, and (d) a dynamic model of the relation between ERI and context. These implications have not been fully considered in the developmental literature but offer important possibilities for moving the field forward in new directions. © 2016 The Author. Child Development © 2016 Society for Research in Child Development, Inc.

  15. The Cross-Thematic Approach and its Implications for Secondary Education with Particular Reference to Greece and Cyprus

    ERIC Educational Resources Information Center

    Dieronitou, Irene

    2009-01-01

    This article examines the impact of the Cross thematic approach on Greek and Greek Cypriot secondary education. The major argument put forward is that the Cross thematic approach (CTA) affects not only pedagogy and educational knowledge but teacher professionalism as well. In justifying this argument, the Cross thematic approach is considered as a…

  16. Making Healthy Choices Easier: Regulation versus Nudging.

    PubMed

    Hansen, Pelle Guldborg; Skov, Laurits Rohden; Skov, Katrine Lund

    2016-01-01

    In recent years, the nudge approach to behavior change has emerged from the behavioral sciences to challenge the traditional use of regulation in public health strategies to address modifiable individual-level behaviors related to the rise of noncommunicable diseases and their treatment. However, integration and testing of the nudge approach as part of more comprehensive public health strategies aimed at making healthy choices easier are being threatened by inadequate understandings of its scientific character, its relationship with regulation, and its ethical implications. This article reviews this character and its ethical implication with a special emphasis on the compatibility of nudging with traditional regulation, special domains of experience, and the need for a more nuanced approach to the ethical debate. The aim is to advance readers' understanding and give guidance to those who have considered working with or incorporating the nudge approach into programs or policies aimed at making healthful choices easier.

  17. Prospective elementary teachers' perceptions of the processes of modeling: A case study

    NASA Astrophysics Data System (ADS)

    Fazio, Claudio; di Paola, Benedetto; Guastella, Ivan

    2012-06-01

    In this paper we discuss a study on the approaches to modeling of students of the 4-year elementary school teacher program at the University of Palermo, Italy. The answers to a specially designed questionnaire are analyzed on the basis of an a priori analysis made using a general scheme of reference on the epistemology of mathematics and physics. The study is performed by using quantitative data analysis methods, i.e. factorial analysis of the correspondences and implicative analysis. A qualitative analysis of key words and terms used by students during interviews is also used to examine some aspects that emerged from the quantitative analysis. The students have been classified on the basis of their different epistemological approaches to knowledge construction, and implications between different conceptual strategies used to answer the questionnaire have been highlighted. The study’s conclusions are consistent with previous research, but the use of quantitative data analysis allowed us to classify the students into three “profiles” related to different epistemological approaches to knowledge construction, and to show the implications of the different conceptual strategies used to answer the questionnaire, giving an estimation of the classification or implication “strength.” Some hints on how a course for elementary school physics and mathematics education can be planned to orient the future teachers to the construction of models of explanation are reported.

  18. Reflections on Klein's radical notion of phantasy and its implications for analytic practice.

    PubMed

    Blass, Rachel B

    2017-06-01

    Analysts may incorporate many of Melanie Klein's important contributions (e.g., on preoedipal dynamics, envy, and projective identification) without transforming their basic analytic approach. In this paper I argue that adopting the Kleinian notion of unconscious phantasy is transformative. While it is grounded in Freud's thinking and draws out something essential to his work, this notion of phantasy introduces a radical change that defines Kleinian thinking and practice and significantly impacts the analyst's basic clinical approach. This impact and its technical implications in the analytic situation are illustrated and discussed. Copyright © 2017 Institute of Psychoanalysis.

  19. Computational modeling approaches to quantitative structure-binding kinetics relationships in drug discovery.

    PubMed

    De Benedetti, Pier G; Fanelli, Francesca

    2018-03-21

    Simple comparative correlation analyses and quantitative structure-kinetics relationship (QSKR) models highlight the interplay of kinetic rates and binding affinity as an essential feature in drug design and discovery. The choice of the molecular series, and their structural variations, used in QSKR modeling is fundamental to understanding the mechanistic implications of ligand and/or drug-target binding and/or unbinding processes. Here, we discuss the implications of linear correlations between kinetic rates and binding affinity constants and the relevance of the computational approaches to QSKR modeling. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. A Review of Social Identity Theory with Implications for Training and Development

    ERIC Educational Resources Information Center

    Korte, Russell F.

    2007-01-01

    Purpose: The purpose of this paper is to review social identity theory and its implications for learning in organizations. Design/methodology/approach: This article is a conceptual paper based on a multidisciplinary review of the literature on social identity theory. This article explains the theoretical concepts, constructs, and findings of an…

  1. Attachment and Resilience: Implications for Children in Care

    ERIC Educational Resources Information Center

    Atwool, Nicola

    2006-01-01

    Attachment theory and resilience theory have developed as two separate bodies of knowledge with their own genealogy. In this paper it is argued that the concepts of attachment and resilience should be regarded as complementary and that each is strengthened by such an approach. The cultural implications are discussed with particular reference to…

  2. Learning through a Disciplined Curriculum Study Approach: Implications for Educational Leadership

    ERIC Educational Resources Information Center

    Henderson, James G.

    2010-01-01

    In this article, the author begins by describing an important present moment in curriculum studies. He then rethinks this moment and briefly explores the implications of this new line of thought for leadership development. At the 2007 American Association for the Advancement of Curriculum Studies' (AAACS) business meeting, Pinar (2007a) presented…

  3. "Learning to Listen": Boys' Gender Narratives--Implications for Theory and Practice

    ERIC Educational Resources Information Center

    Farrell, Francis

    2016-01-01

    Purpose: The purpose of this paper is to critically investigate year 6 and year 9 boys' constructions of masculinity in the light of theories of inclusive masculinity and to consider the implications of the findings for critical masculinities scholarship in educational research. Design/methodology/approach: Qualitative data was collected through…

  4. Critical Issues in Conducting Research with Immigrant Children

    ERIC Educational Resources Information Center

    Kirova, Anna; Emme, Michael

    2007-01-01

    In this article, we explore critical issues in research with immigrant and refugee children. In particular, we examine the implications of various critiques of research methodologies, the ethical implications of researching children in the light of the United Nations (UN; 1989) "Convention on the Rights of the Child," and the new approach to…

  5. Spirituality and Loss: Approaches for Counseling Grieving Adolescents

    ERIC Educational Resources Information Center

    Muselman, Dannette M.; Wiggins, Marsha I.

    2012-01-01

    The death of a loved one has serious implications for adolescent growth and development. The authors review relevant research on the grief process and spirituality in adolescence, and they give a rationale for integrating spirituality into adolescent grief work. By way of a case illustration, they draw implications for counselors' use of…

  6. Implications for Teacher Effectiveness Research in Deaf Education from the Cognitive Paradigm.

    ERIC Educational Resources Information Center

    Mertens, Donna M.

    The paper identifies a paradigm shift in research on teaching effectiveness from the process-product approach to explanations from cognitive psychology related to mediating variables which intervene between teacher behavior and pupil performance. Implications of this paradigm shift for research on the effectiveness of teachers of deaf students are…

  7. Task Type and Group Motivation: Implications for a Behavioral Approach to Leadership in Small Groups.

    ERIC Educational Resources Information Center

    Latham, Van M.

    1987-01-01

    Discusses a theory of leadership effectiveness in small discussion/decision making groups developed to facilitate discussion and goal efficacy. Develops four leadership styles (coordinator, inventor, enthusiast, and director) focusing on two critical questions the leader must address. Discusses implications of the model for leadership training and…

  8. Philosophical and Socio-Cognitive Foundations for Teaching in Higher Education through Collaborative Approaches to Student Learning

    ERIC Educational Resources Information Center

    Jones, Adrian

    2011-01-01

    This paper considers the implications for higher education of recent work on narrative theory, distributed cognition and artificial intelligence. These perspectives are contrasted with the educational implications of Heidegger's ontological phenomenology [being-there and being-aware (Da-sein)] and with the classic and classical foundations of…

  9. "Perezhivanie": Advancing on Its Implications for the Cultural-Historical Approach

    ERIC Educational Resources Information Center

    Rey, Fernando Luís González; Martínez, Albertina Mitjáns

    2016-01-01

    This paper aims to discuss the relevance that the concept of "perezhivanie" had for Soviet psychology and its implication for the development of topics that have been largely neglected both in Soviet psychology and in the Western Vygotskian tradition. According to the position defended in this paper, "perezhivanie" is not just…

  10. Applying a Cognitive Neuroscience Perspective to Disruptive Behavior Disorders: Implications for Schools.

    PubMed

    Tyler, Patrick M; White, Stuart F; Thompson, Ronald W; Blair, R J R

    2018-02-12

    A cognitive neuroscience perspective seeks to understand behavior, in this case disruptive behavior disorders (DBD), in terms of dysfunction in cognitive processes underpinned by neural processes. While this type of approach has clear implications for clinical mental health practice, it also has implications for school-based assessment and intervention with children and adolescents who have disruptive behavior and aggression. This review articulates a cognitive neuroscience account of DBD by discussing the neurocognitive dysfunction related to emotional empathy, threat sensitivity, reinforcement-based decision-making, and response inhibition. The potential implications for current and future classroom-based assessments and interventions for students with these deficits are discussed.

  11. Taking a narrative approach to grief research: finding meaning in stories.

    PubMed

    Gilbert, Kathleen R

    2002-04-01

    This article explores the concepts of narrative as story, of storytelling, and of the narrative approach to qualitative research. Within this, I will also examine the social nature of narrative and the implications of this for research. I will look at the process of conducting a narrative study and the implications for participation in such a project and for the researcher investigating a phenomenon through this frame. In particular, the need to create stories to make order of disorder and find meaning in the meaningless is particularly relevant to the study of grief. In looking at the process of conducting a narrative study, questions about what can be analyzed and how it might be presented, some strengths and limitations of the narrative approach, and ethical questions also are considered.

  12. Unaccompanied Children Migrating from Central America: Public Health Implications for Violence Prevention and Intervention

    PubMed Central

    Ports, Katie A.; Hipp, Tracy

    2017-01-01

    Purpose of Review Unaccompanied children (UC) migrating to the USA from the Central American countries of El Salvador, Guatemala, and Honduras are an underserved population at high risk for health, academic, and social problems. These children experience trauma, violence, and other risk factors that are shared among several types of interpersonal violence. Recent Findings The trauma and violence experienced by many unaccompanied children, and the subsequent implications for their healthy development into adulthood, indicate the critical need for a public health approach to prevention and intervention. Summary This paper provides an overview of the violence experienced by unaccompanied children along their migration journey, the implications of violence and trauma for the health and well-being of the children across their lifespan, prevention and intervention approaches for UC resettled in the USA, and suggestions for adapted interventions to best address the unique needs of this vulnerable population. PMID:29456924

  13. Behavioral Approach in ADHD: Testing a Motivational Dysfunction Hypothesis

    ERIC Educational Resources Information Center

    Mitchell, John T.

    2010-01-01

    Objective: Etiological models of attention-deficit hyperactivity disorder (ADHD) increasingly support the role of a motivational dysfunction pathway, particularly for hyperactive-impulsive symptoms. Overactive behavioral approach tendencies are implicated among these motivational accounts. However, other externalizing disorder symptoms, such as…

  14. Children under Five and Digital Technologies: Implications for Early Years Pedagogy

    ERIC Educational Resources Information Center

    Palaiologou, Ioanna

    2016-01-01

    This project aimed to investigate the types of digital technologies children under the age of five are using at home and assess the possible implications for early years pedagogy. The research, carried out between 2010 and 2012, was based in four European countries: England, Greece, Malta and Luxemburg. A mixed methods approach was employed to…

  15. Riding out the Storm: Graduates, Enterprise and Careers in Turbulent Economic Times

    ERIC Educational Resources Information Center

    Rae, David

    2008-01-01

    Purpose: The purpose of this paper is to explore the possible implications for graduate employability of the economic changes which are affecting the UK in the wake of the "credit crunch". It explores the changing economic context and its implications both for HEIs and for graduates starting their careers. Design/methodology/approach:…

  16. Toward an Integral Approach for Evolving Mindsets for Generative Learning and Timely Action in the Midst of Ambiguity

    ERIC Educational Resources Information Center

    Yorks, Lyle; Nicolaides, Aliki

    2013-01-01

    Background/Context: The implications of complexity theory have become a recurring topic in the literatures of a wide range of scholarly and professional fields including adult education. This paper builds on literature calling attention to the educational need for pedagogically addressing the implications of the intensifying complexity in the…

  17. On the Implications of Vygotskian Concepts for Second Language Teaching

    ERIC Educational Resources Information Center

    Azabdaftari, Behrooz

    2013-01-01

    This paper represents an attempt to search for the implications of Vygotsky's approach to "the genesis of mind" for second language acquisition (SLA). In so doing, the present author has adopted first a retrospective view--what has already gone in the field of foreign language instruction, and a prospective view--what is contingent on…

  18. Bolzano's Approach to the Paradoxes of Infinity: Implications for Teaching

    ERIC Educational Resources Information Center

    Waldegg, Guillermina

    2005-01-01

    In this paper we analyze excerpts of "Paradoxes of the Infinite", the posthumous work of Bernard Bolzano (1781-1848), in order to show that Georg Cantor's (1845-1918) approach to the problem of defining actual mathematical infinity is not the most natural. In fact, Bolzano's approach to the paradoxes of infinity is more intuitive, while remaining…

  19. The Service Implications of a Rhetorical Approach to Information Literacy

    ERIC Educational Resources Information Center

    Brannon, Brittany

    2017-01-01

    Brittany Brannon is an MLIS candidate in the School of Library and Information Science at Kent State University. In this essay, she makes an argument for incorporating a rhetorical approach when assisting students with their information seeking and use. A rhetorical approach focuses on how the student will use the information they seek, and thus…

  20. Abandoning Patchwork Approaches to Nature of Science in Science Education

    ERIC Educational Resources Information Center

    Dagher, Zoubeida R.; Erduran, Sibel

    2017-01-01

    The purpose of this commentary on Hodson and Wong's (2017, this issue) article is to clarify the merits of the expanded family resemblance approach (FRA) to science education, briefly alluded to in their article, and to discuss the implications of this approach relative to the question of demarcation they raise. In clarifying the merits of the…

  1. Taxonomic Approaches to Enlisted Occupational Classification. Volume II,

    DTIC Science & Technology

    1979-12-01

    various media and about the social implications of the more pervasive of these, there is little of communication theory that is useful to those who...Folley’s theory is a system of interrelated definitions, constructs, and hypotheses relating task attributes to training requirements. D. C. Berliner...requirement approach, the task characteristics approach, and a third approach based on information theory . During the third project year, two of the

  2. Reframing the Interpretation of Sex Worker Health: A Behavioral–Structural Approach

    PubMed Central

    Tuminez, Astrid S.

    2011-01-01

    Expanding sexually transmitted infection (STI) epidemics in many parts of Asia increase the importance of effective human immunodeficiency virus (HIV)/STI prevention programs for female sex workers. Designing sex worker health research and programs demands a well-stated conceptual approach, especially when one is interpreting the relationship between local policy environments and sex worker health. However, the core principles of the 2 most common conceptual approaches used in sex worker health programs—abolitionism and empowerment—have frequently divergent assumptions and implications. The abolitionist approach sees major aspects of the sex industry as fundamentally coercive and exploitative of women and supports dismantling all or parts of the sex sector. The empowerment approach strengthens sex workers’ agency and rights in order to build collective self-efficacy and have women invested in implementing their own HIV/STI prevention programs. This review compares these approaches using implication analysis and empirical cases from Asia. The misperception of an unresolvable gap between the 2 approaches ignores common ground that forms the basis of a new behavioral–structural conceptual framework. Explicitly accounting for the interaction between female sex worker behaviors and larger structures and policies, a behavioral–structural approach may provide a solid foundation for sex work research and programs. PMID:22043033

  3. Contextual approach to technology assessment: Implications for one-factor fix solutions to complex social problems

    NASA Technical Reports Server (NTRS)

    Mayo, L. H.

    1975-01-01

    The contextual approach is discussed which undertakes to demonstrate that technology assessment assists in the identification of the full range of implications of taking a particular action and facilitates the consideration of alternative means by which the total affected social problem context might be changed by available project options. It is found that the social impacts of an application on participants, institutions, processes, and social interests, and the accompanying interactions may not only induce modifications in the problem contest delineated for examination with respect to the design, operations, regulation, and use of the posited application, but also affect related social problem contexts.

  4. Psychotropics without borders: ethics and legal implications of internet-based access to psychiatric medications.

    PubMed

    Klein, Carolina A

    2011-01-01

    Medical practitioners are revisiting many of the ethics and the legal implications surrounding the clinical frameworks within which we operate. In today's world, distinguishing between virtual and physical reality continues to be increasingly difficult. The physician may be found grappling with the decision of whether to continue to treat a patient who may be obtaining psychotropic medications through the Internet. This article approaches some of the clinical and legal implications and the ethics regarding the availability of prescription psychotropics over the Internet.

  5. Perceiving outgroup members as unresponsive: implications for approach-related emotions, intentions, and behavior.

    PubMed

    Butz, David A; Plant, E Ashby

    2006-12-01

    In 2 studies, the authors investigated the determinants of anger and approach-related intentions and behavior toward outgroup members in interracial interactions. In Study 1, White and Black participants who were led to believe that their interracial interaction partner was not open to an upcoming interaction reported heightened anger and approach-related intentions concerning the interaction, including viewing their partner as hostile, intending to ask sensitive race-relevant questions during the interaction, and planning to blame the partner if the interaction went poorly. Results of Study 2 showed that White participants who received negative feedback about their Black partner's openness to interracial interactions behaved in a hostile manner toward their interaction partner. The findings are discussed in terms of their implications for the quality of interracial interactions. (c) 2006 APA, all rights reserved.

  6. Pelvi-ureteric junction obstruction related to crossing vessels: vascular anatomic variations and implication for surgical approaches.

    PubMed

    Panthier, Frédéric; Lareyre, Fabien; Audouin, Marie; Raffort, Juliette

    2018-03-01

    Pelvi-ureteric junction obstruction corresponds to an impairment of urinary transport that can lead to renal dysfunction if not treated. Several mechanisms can cause the obstruction of the ureter including intrinsic factors or extrinsic factors such as the presence of crossing vessels. The treatment of the disease relies on surgical approaches, pyeloplasty being the standard reference. The technique consists in removing the pathologic ureteric segment and renal pelvis and transposing associated crossing vessels if present. The vascular anatomy of the pelvi-ureteric junction is complex and varies among individuals, and this can impact on the disease development and its surgical treatment. In this review, we summarize current knowledge on vascular anatomic variations in the pelvi-ureteric junction. Based on anatomic characteristics, we discuss implications for surgical approaches during pyeloplasty and vessel transposition.

  7. State medical marijuana laws: understanding the laws and their limitations.

    PubMed

    Pacula, Rosalie Liccardo; Chriqui, Jamie F; Reichmann, Deborah A; Terry-McElrath, Yvonne M

    2002-01-01

    Significant attention has been given to the debate regarding allowances for medical marijuana use since the 1996 California and Arizona ballot initiatives. State medical marijuana allowances, however, have existed since the mid-1970s. Much of the current debate stems from confusion about the various ways states approach the issue. In this paper, we present original legal research on current state medical marijuana laws identifying four different ways states statutorily enable the medical use of marijuana. We discuss the tension these approaches have with federal law as well as their implications regarding real access for patients. In addition, we present information on how a small number of states are trying to deal with the issue of access within the context of their medical marijuana laws, and discuss the implication of various supply approaches on the enforcement of other state marijuana laws.

  8. How do local stakeholders respond to the uncertain implications of an innovative flood infrastructure project?

    NASA Astrophysics Data System (ADS)

    van den Hoek, Ronald; Brugnach, Marcela; Hoekstra, Arjen

    2013-04-01

    In the 20th century, flood management was dominated by rigid structures - such as dikes and dams - which intend to strictly regulate and control water systems. Although the application of these rigid structures has been successful in the recent past, their negative implications for ecosystems and natural processes is often not properly taken into account. Therefore, flood management practices are currently moving towards more nature-inclusive approaches. Building with Nature (BwN) is such a new approach of nature-inclusive flood management in the Netherlands, which aims to utilize natural dynamics (e.g., wind and currents) and natural materials (e.g., sediment and vegetation) for the realization of effective flood infrastructure, while providing opportunities for nature development. However, the natural dynamics driving a project based on BwN design principles are inherently unpredictable. Furthermore, our factual knowledge base regarding the socio-ecological system in which the BwN initiative is implemented is incomplete. Moreover, in recent years, it is increasingly aimed for by decision-makers to involve local stakeholders in the development of promising flood management initiatives. These stakeholders and other actors involved can have diverging views regarding the project, can perceive unanticipated implications and could choose unforeseen action paths. In short, while a project based on BwN design principles - like any human intervention - definitely has implications for the socio-ecological system, both the extent to which these particular implications will occur and the response of stakeholders are highly uncertain. In this paper, we study the Safety Buffer Oyster Dam case - a BwN pilot project - and address the interplay between the project's implications, the uncertainties regarding these implications and the action paths chosen by the local stakeholders and project team. We determine how the implications of the Safety Buffer project are viewed by local stakeholders, identify the frames and uncertainties related to these implications, and classify these uncertainties according to their nature and level. We describe which action paths are chosen by the local stakeholders and project team regarding the implications identified. Our research shows that there is a correspondence between the level of uncertainty about the implications identified and the action paths chosen by the actors involved. This suggests that the inherent deep uncertainty in projects based on BwN principles calls for more adaptable and flexible strategies to cope with the implications of these initiatives.

  9. Midstream Modulation of Technology: Governance from Within

    ERIC Educational Resources Information Center

    Fisher, Erik; Mahajan, Roop L.; Mitcham, Carl

    2006-01-01

    Public "upstream engagement" and other approaches to the social control of technology are currently receiving international attention in policy discourses around emerging technologies such as nanotechnology. To the extent that such approaches hold implications for research and development (R&D) activities, the distinct participation of scientists…

  10. Family Therapy with Reconstituted Families: A Crisis-Induction Approach.

    ERIC Educational Resources Information Center

    Baptiste, David A.

    1983-01-01

    Describes a crisis-based therapeutic approach for overcoming resistance in reconstituted families. Presents therapeutically induced crisis as a means through which therapists might purposefully disequilibrate families in which resistance is high and subsequently redirect them to meaningful change. Reviews implications and contraindications for the…

  11. A Restorative Justice Approach to Empathy Development in Sex Offenders: An Exploratory Study

    ERIC Educational Resources Information Center

    Roseman, Christopher P.; Ritchie, Martin; Laux, John M.

    2009-01-01

    The authors describe an exploratory study in sex offender treatment using a restorative justice approach to examine the shame, guilt, and empathy development of convicted sexual offenders. Implications for clinical practice and future research are highlighted. (Contains 3 tables.)

  12. Trait Approach and Avoidance Motivation: Lateralized Neural Activity Associated with Executive Function

    PubMed Central

    Spielberg, Jeffrey M.; Miller, Gregory A.; Engels, Anna S.; Herrington, John D.; Sutton, Bradley P.; Banich, Marie T.; Heller, Wendy

    2010-01-01

    Motivation and executive function are both necessary for the completion of goal-directed behavior. Research investigating the manner in which these processes interact is beginning to emerge and has implicated middle frontal gyrus (MFG) as a site of interaction for relevant neural mechanisms. However, this research has focused on state motivation, and it has not examined functional lateralization. The present study examined the impact of trait levels of approach and avoidance motivation on neural processes associated with executive function. Functional magnetic resonance imaging was conducted while participants performed a color-word Stroop task. Analyses identified brain regions in which trait approach and avoidance motivation (measured by questionnaires) moderated activation associated with executive control. Approach was hypothesized to be associated with left-lateralized MFG activation, whereas avoidance was hypothesized to be associated with right-lateralized MFG activation. Results supported both hypotheses. Present findings implicate areas of middle frontal gyrus in top-down control to guide behavior in accordance with motivational goals. PMID:20728552

  13. Trait approach and avoidance motivation: lateralized neural activity associated with executive function.

    PubMed

    Spielberg, Jeffrey M; Miller, Gregory A; Engels, Anna S; Herrington, John D; Sutton, Bradley P; Banich, Marie T; Heller, Wendy

    2011-01-01

    Motivation and executive function are both necessary for the completion of goal-directed behavior. Research investigating the manner in which these processes interact is beginning to emerge and has implicated middle frontal gyrus (MFG) as a site of interaction for relevant neural mechanisms. However, this research has focused on state motivation, and it has not examined functional lateralization. The present study examined the impact of trait levels of approach and avoidance motivation on neural processes associated with executive function. Functional magnetic resonance imaging was conducted while participants performed a color-word Stroop task. Analyses identified brain regions in which trait approach and avoidance motivation (measured by questionnaires) moderated activation associated with executive control. Approach was hypothesized to be associated with left-lateralized MFG activation, whereas avoidance was hypothesized to be associated with right-lateralized MFG activation. Results supported both hypotheses. Present findings implicate areas of middle frontal gyrus in top-down control to guide behavior in accordance with motivational goals. Copyright © 2010 Elsevier Inc. All rights reserved.

  14. Facilitation of creative performance by using blue and red accent lighting in work and learning areas.

    PubMed

    Kombeiz, Olga; Steidle, Anna

    2018-03-01

    Research has shown that colours influence motivation and cognitive performance. In achievement contexts, red evokes avoidance motivation that hinders creativity, while blue elicits an approach motivation that facilitates creativity. However, due to their position and mode of presentation, colours may convey a different message. Red accent lighting creates a cosy, friendly room atmosphere that may, even in an achievement context, elicit an approach rather than an avoidance motivation. Results (N = 146) showed that both blue and red accent light increased strategic approach motivation compared to white accent light. Moreover, through the heightened approach motivation, colourful accent light indirectly improved creative performance. Implications for future research on colour and practical implications for colour usage are discussed. Practitioner Summary: Designing work environments for creativity is a new topic in ergonomics research and practice. The present study demonstrates indirect effects of coloured accent light on creativity providing interesting possibilities for the design of workplaces for knowledge workers, classrooms and all other rooms in which people work on new ideas.

  15. A Posthumanist Approach to Environmental Education in South Africa: Implications for Teachers, Teacher Development, and Teacher Training Programs

    ERIC Educational Resources Information Center

    Blyth, Carmen; Meiring, Rouxnette

    2018-01-01

    As we enter the sixth great mass extinction event, an event that points to humanity's exploitative attitude towards nature, posthumanist ethics offers a different way of engaging with the world, a way which has clear and extensive implications for the way environmental education is taught in South African schools. However, given the official…

  16. Trends in Smoking among Adolescents and Young Adults in the United Kingdom: Implications for Health Education

    ERIC Educational Resources Information Center

    Sandford, Amanda

    2008-01-01

    Purpose: The purpose of this paper is to examine trends in smoking prevalence among adolescents and young adults in the UK and to identify any developments in health education theory and practice relating to adolescent tobacco use since 2000. The implications of such research are discussed. Design/methodology/approach: A literature search was…

  17. Job Enrichment: Evaluation with Implications for Air Force Job Redesign. Interim Report, 1 January 1975-30 April 1977.

    ERIC Educational Resources Information Center

    Watson, Thomas W.; Zumbro, Patrick A.

    The main text of this report consists of a review and evaluation of job enrichment as an approach to job redesign, with implications for Air Force research and application. In addition, two appendixes are included: the first, a supplemental historical discussion; the second, a ninety-six-item annotated bibliography. Specific objectives are to…

  18. Paid Educational Leave and Self-Directed Learning: Implications for Legislation on the Learning Leave Scheme in South Korea

    ERIC Educational Resources Information Center

    Oh, Jeong Rok; Park, Cho Hyun; Jo, Sung Jun

    2016-01-01

    Purpose: The purposes of this study are to explore paid educational leave (PEL), self-directed learning (SDL) and the relationship between them; and to identify the implications for legislation on the learning leave scheme in South Korea. Design/Methodology/Approach: The research method of the study is a literature review. Articles were identified…

  19. Strengths-Based Approaches in College and University Student Housing: Implications for First-Year Students' Retention and Engagement

    ERIC Educational Resources Information Center

    Soria, Krista M.; Taylor, Leonard, Jr.

    2016-01-01

    Strengths-based approaches are expanding in higher education; however, little is known about the impacts of these approaches in housing and residence life settings. The purpose of this study was to examine the associations between first-year students' strengths interactions in housing and their engagement and retention. The results suggest that…

  20. Implications of DSM-5 for Health Care Organizations and Mental Health Policy.

    PubMed

    Castillo, Richard J; Guo, Kristina L

    2016-01-01

    The American Psychiatric Association (APA) has made major changes in the way mental illness is conceptualized, assessed, and diagnosed in its new diagnostic manual, the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), published in 2013, and has far reaching implications for health care organizations and mental health policy. This paper reviews the four new principles in DSM-5: 1) A spectrum (also called "dimensional") approach to the definition of mental illness; 2) recognition of the role played by environmental risk factors related to stress and trauma in predisposing, precipitating, and perpetuating mental illness; 3) cultural relativism in diagnosis and treatment of mental illness; and 4) recognizing the adverse effects of psychiatric medications on patients. Each of these four principles will be addressed in detail. In addition, four major implications for health care organizations and mental health policy are identified as: 1) prevention; 2) client-centered psychiatry; 3) mental health workers retraining; and 4) medical insurance reform. We conclude that DSM- 5's new approach to diagnosis and treatment of mental illness will have profound implications for health care organizations and mental health policy, indicating a greater emphasis on prevention and cure rather than long-term management of symptoms.

  1. Adaptive approaches to licensing, health technology assessment, and introduction of drugs and devices.

    PubMed

    Husereau, Don; Henshall, Chris; Jivraj, Jamil

    2014-07-01

    Adaptive approaches to the introduction of drugs and medical devices involve the use of an evolving evidence base rather than conventional single-point-in-time evaluations as a proposed means to promote patient access to innovation, reduce clinical uncertainty, ensure effectiveness, and improve the health technology development process. This report summarizes a Health Technology Assessment International (HTAi) Policy Forum discussion, drawing on presentations from invited experts, discussions among attendees about real-world case examples, and background paper. For adaptive approaches to be understood, accepted, and implemented, the Forum identified several key issues that must be addressed. These include the need to define the goals of and to set priorities for adaptive approaches; to examine evidence collection approaches; to clarify the roles and responsibilities of stakeholders; to understand the implications of adaptive approaches on current legal and ethical standards; to determine costs of such approaches and how they will be met; and to identify differences in applying adaptive approaches to drugs versus medical devices. The Forum also explored the different implications of adaptive approaches for various stakeholders, including patients, regulators, HTA/coverage bodies, health systems, clinicians, and industry. A key outcome of the meeting was a clearer understanding of the opportunities and challenges adaptive approaches present. Furthermore, the Forum brought to light the critical importance of recognizing and including a full range of stakeholders as contributors to a shared decision-making model implicit in adaptive pathways in future discussions on, and implementation of, adaptive approaches.

  2. Science and Sanity in Special Education.

    ERIC Educational Resources Information Center

    Dammann, James E.; Vaughn, Sharon

    2001-01-01

    This article describes the usefulness of a scientific approach to improving knowledge and practice in special education. Of four approaches to knowledge (superstition, folklore, craft, and science), craft and science are supported and implications for special education drawn including the need to bridge the gulf between research knowledge and…

  3. Contrasting Conceptions of Intelligence and their Educational Implications. Technical Report No. 14.

    ERIC Educational Resources Information Center

    Sternberg, Robert J.

    The componential conception of intelligence is summarized and contrasted with the psychometric conception. A brief history of concepts of intelligence is presented, beginning with Galton's anthropometric approach and Binet's more educationally relevant approach. Spearman's, and later Thurstone's, contributions to factor analysis promoted a…

  4. MOOC Quality: The Need for New Measures

    ERIC Educational Resources Information Center

    Hood, Nina; Littlejohn, Allison

    2016-01-01

    MOOCs are re-operationalising traditional concepts in education. While they draw on elements of existing educational and learning models, they represent a new approach to instruction and learning. The challenges MOOCs present to traditional education models have important implications for approaching and assessing quality. This paper foregrounds…

  5. Aptitude x Treatment Interactions: Implications for Patient Education Research.

    ERIC Educational Resources Information Center

    Holloway, Richard L.; And Others

    1988-01-01

    Aptitude treatment interaction (ATI) identifies patient characteristics and optimal instructional treatments, is compatible with psychological theories and clinical approaches, and offers a specific methodology for approaching existing problems in a new way. This article presents studies in which ATI has illuminated patient needs and treatments…

  6. Multicultural Music Instruction in the Elementary School: What Can Be Achieved?

    ERIC Educational Resources Information Center

    Edwards, Kay L.

    1998-01-01

    Investigates fourth-grade students' achievement following a model unit on American Indian music that utilized four different instructional approaches. Suggests implications for instruction with American Indian music regarding instructional approach, authenticity of instrument materials, learning from a native guest artist, and music teacher…

  7. A Critical Review of Leadership Concepts and Research: The Implications for Educational Administration.

    ERIC Educational Resources Information Center

    Watkins, Peter

    This monograph critiques the literature on organizational and educational leadership, asserting that traditional approaches are unsatisfactory in their own right and within the existing positivist-functionalist paradigm. After outlining problems in defining leadership, the paper critically examines the "trait" approach, particularly…

  8. Cross-Curricular Sequence: An Approach for Teaching Business Communication.

    ERIC Educational Resources Information Center

    Clarke, Lillian W.; Franklin, Carl M.

    1985-01-01

    The Cross-Curricular Sequencing (CCS) approach to teaching business communications is explored. Its uses in word processing, principles of management, and business policy courses are discussed. Techniques for integrating materials from these courses into business communication classes are described. The implications of CCS for business…

  9. A critical review of principal traffic noise models: Strategies and implications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garg, Naveen, E-mail: ngarg@mail.nplindia.ernet.in; Department of Mechanical, Production and Industrial Engineering, Delhi Technological University, Delhi 110042; Maji, Sagar

    2014-04-01

    The paper presents an exhaustive comparison of principal traffic noise models adopted in recent years in developed nations. The comparison is drawn on the basis of technical attributes including source modelling and sound propagation algorithms. Although the characterization of source in terms of rolling and propulsion noise in conjunction with advanced numerical methods for sound propagation has significantly reduced the uncertainty in traffic noise predictions, the approach followed is quite complex and requires specialized mathematical skills for predictions which is sometimes quite cumbersome for town planners. Also, it is sometimes difficult to follow the best approach when a variety ofmore » solutions have been proposed. This paper critically reviews all these aspects pertaining to the recent models developed and adapted in some countries and also discusses the strategies followed and implications of these models. - Highlights: • Principal traffic noise models developed are reviewed. • Sound propagation algorithms used in traffic noise models are compared. • Implications of models are discussed.« less

  10. Practices and Policies of Clinical Exome Sequencing Providers: Analysis and Implications

    PubMed Central

    Jamal, Seema M.; Yu, Joon-Ho; Chong, Jessica X.; Dent, Karin M.; Conta, Jessie H.; Tabor, Holly K.; Bamshad, Michael J.

    2013-01-01

    Exome and whole genome sequencing (ES/WGS) offer potential advantages over traditional approaches to diagnostic genetic testing. Consequently, use of ES/WGS in clinical settings is rapidly becoming commonplace. Yet there are myriad moral, ethical, and perhaps legal implications attached to the use of ES and health care professionals and institutions will need to consider these implications in the context of the varied practices and policies of ES service providers. We developed “core elements” of content and procedures for informed consent, data sharing, and results management and a quantitative scale to assess the extent to which research protocols met the standards established by these core elements. We then used these tools to evaluate the practices and policies of each of the 6 U.S. CLIA-certified labs offering clinical ES. Approaches toward informed consent, data sharing, and results return vary widely among ES providers as do the overall potential merits and disadvantages of each, and more importantly, the balance between the two. PMID:23610049

  11. Convergence and Divergence of Process and Portfolio Approaches to L2 Writing Instruction: Issues and Implications

    ERIC Educational Resources Information Center

    Lam, Ricky

    2015-01-01

    In the L2 writing literature, there has been a rich history of scholarship in theory, research and practice since the 1960s. Two of the most prominent L2 writing approaches are process and portfolio pedagogy. The former approach promotes the use of diverse writing strategies (e.g. pre-writing) to enhance student writers' expression and fluency.…

  12. Introduction to the Special Series: Current Directions for Measuring Parenting Constructs to Inform Prevention Science.

    PubMed

    Lindhiem, Oliver; Shaffer, Anne

    2017-04-01

    Parenting behaviors are multifaceted and dynamic and therefore challenging to quantify. Measurement methods have critical implications for study results, particularly for prevention trials designed to modify parenting behaviors. Although multiple approaches can complement one another and contribute to a more complete understanding of prevention trials, the assumptions and implications of each approach are not always clearly addressed. Greater attention to the measurement of complex constructs such as parenting is needed to advance the field of prevention science. This series examines the challenges of measuring changes in parenting behaviors in the context of prevention trials. All manuscripts in the special series address measurement issues and make practical recommendations for prevention researchers. Manuscripts in this special series include (1) empirical studies that demonstrate novel measurement approaches, (2) re-analyses of prevention trial outcome data directly comparing and contrasting two or more methods, and (3) a statistical primer and practical guide to analyzing proportion data.

  13. Cerebral amyloid angiopathy, cerebral microbleeds and implications for anticoagulation decisions: The need for a balanced approach.

    PubMed

    Charidimou, Andreas; Shoamanesh, Ashkan; Al-Shahi Salman, Rustam; Cordonnier, Charlotte; Perry, Luke A; Sheth, Kevin N; Biffi, Alessandro; Rosand, Jonathan; Viswanathan, Anand

    2018-02-01

    Cerebral amyloid angiopathy is a common hemorrhagic small vessel disease of the brain, often associated with high risk of spontaneous lobar intracerebral hemorrhage. When the suspicion of cerebral amyloid angiopathy is raised, clinicians are hesitant in prescribing oral anticoagulation in patients in whom it is otherwise indicated, including the case of non-valvular atrial fibrillation. This is one of the thorniest clinical dilemmas in the field currently. In this short Leading Opinion piece by an international panel of clinicians-researchers active in the field, we present our consistent approach and future outlook on oral anticoagulation post intracerebral hemorrhage and in the setting of clinical-radiologic evidence of cerebral amyloid angiopathy. We discuss recent advances and support a more balanced approach with implications for the wider neurological clinical community in regards to successful recruiting this patient population in ongoing and future randomized trials.

  14. The ecosystem approach to health is a promising strategy in international development: lessons from Japan and Laos.

    PubMed

    Asakura, Takashi; Mallee, Hein; Tomokawa, Sachi; Moji, Kazuhiko; Kobayashi, Jun

    2015-02-16

    An ecological perspective was prominently present in the health promotion movement in the 1980s, but this seems to have faded. The burden of disease the developing world is facing cannot be addressed solely by reductionist approaches. Holistic approaches are called for that recognize the fundamentally interdependent nature of health and other societal, developmental, and ecosystem related factors in human communities. An ecosystem approach to human health (ecohealth) provides a good starting point to explore these interdependencies. Development assistance is often based on the assumption that developed countries can serve as models for developing ones. Japan has provided lavish assistance to Laos for example, much of it going to the development of transport networks. However, there is little sign that there is an awareness of the potentially negative environmental and health impacts of this assistance. We argue that the health consequences of environmental degradation are not always understood, and that developing countries need to consider these issues. The ecohealth approach is useful when exploring this issue. We highlight three implications of the ecohealth approach: (1) The WHO definition of health as a state of complete physical, mental and social well-being emphasized that health is more than the absence of disease. However, because this approach may involve an unattainable goal, we suggest that health should be defined in the ecosystem context, and the goal should be to attain acceptable and sustainable levels of health through enabling people to realize decent livelihoods, and to pursue their life purpose; (2) The increasing interconnectedness of ecosystems in a globalizing world requires an ethical approach that considers human responsibility for the global biosphere. Here, ecohealth could be a countervailing force to our excessive concentration on economy and technology; and (3) If ecohealth is to become a positive agent of change in the global health promotion movement, it will have to find a secure place in the educational curriculum. This article presents a brief case study of Japan's development assistance to Laos, and its environmental and health implications, as an illustration of the ecohealth approach. We highlight three implications of the ecohealth perspective.

  15. Megacity analysis: a clustering approach to classification

    DTIC Science & Technology

    2017-06-01

    kinetic or non -kinetic urban operations. We develop and implement a methodology to classify megacities into groups. Using 33 variables, we construct a...is interested in these megacity networks and their implications for potential urban operations. We develop a methodology to group like megacities...is interested in these megacity networks and their implications for potential urban operations. We develop a methodology to group like megacities

  16. The Impact and the Implications of Policy Regarding the Organisation of Support for Pupils with Dyslexia in Irish Primary Mainstream Schools

    ERIC Educational Resources Information Center

    Tiernan, Bairbre; Casserly, Ann Marie

    2018-01-01

    There have been vast changes in relation to the way educational teaching support provision is organised for pupils with dyslexia in Ireland. A qualitative research approach was utilised to examine the impact and implications of the General Allocation Model (GAM) regarding the organisation of support for pupils with dyslexia in Irish Primary…

  17. From Fatigue to Anxiety? Implications for Educational Design in a Web 2.0 World

    ERIC Educational Resources Information Center

    Mathew, David

    2012-01-01

    Purpose: The purpose of the paper is to recognise that as educators moving into, or already in, a Web 2.0 world, we are likely to experience anxiety, and to explore the implications for educational design in a Web 2.0 world. Design/methodology/approach: The objectives are achieved as the result of recent successes with the commissioners for two…

  18. Enactive Metaphors: Learning through Full-Body Engagement

    ERIC Educational Resources Information Center

    Gallagher, Shaun; Lindgren, Robb

    2015-01-01

    Building on both cognitive semantics and enactivist approaches to cognition, we explore the concept of enactive metaphor and its implications for learning. Enactive approaches to cognition involve the idea that online sensory-motor and affective processes shape the way the perceiver-thinker experiences the world and interacts with others.…

  19. Primary English and a Communicative Approach.

    ERIC Educational Resources Information Center

    de Jong, W. N.

    The decision in the Netherlands to teach English as a second language to all students in grades five and six, by the regular class teacher, has implications for the selection of instructional approaches and materials. A clear preference for communication goals in language instruction has been shown in the Netherlands, suggesting a…

  20. Personal Development Plans: Insights from a Case Based Approach

    ERIC Educational Resources Information Center

    Greenan, Peter

    2016-01-01

    Purpose: In light of contemporary shifts away from annual appraisals, this study aims to explore the implications of using a personal development plan (PDP) as a means of focussing on continuous feedback and development to improve individual performance and ultimately organisational performance. Design/methodology/approach: Data were collected…

  1. Participatory Action Research and Environmental Learning: Implications for Resilient Forests and Communities

    ERIC Educational Resources Information Center

    Ballard, Heidi L.; Belsky, Jill M.

    2010-01-01

    How can a participatory approach to research promote environmental learning and enhance social-ecological systems resilience? Participatory action research (PAR) is an approach to research that its' supporters claim can foster new knowledge, learning, and action to support positive social and environmental change through reorienting the standard…

  2. Reading as the Interpretation of Signs

    ERIC Educational Resources Information Center

    Dressman, Mark

    2016-01-01

    This study examines the challenges of analyzing texts that are multimodal--that is, combining more than one mode of communication, such as written text, images, video, and/or audio--and considers the theoretical and practical implications of two very different approaches. The more common current approach, which adapts the work of Halliday and…

  3. Some Psychometric and Design Implications of Game-Based Learning Analytics

    ERIC Educational Resources Information Center

    Gibson, David; Clarke-Midura, Jody

    2013-01-01

    The rise of digital game and simulation-based learning applications has led to new approaches in educational measurement that take account of patterns in time, high resolution paths of action, and clusters of virtual performance artifacts. The new approaches, which depart from traditional statistical analyses, include data mining, machine…

  4. Teaching Science for Understanding: Implications of Spontaneous Conceptions and the History of Science.

    ERIC Educational Resources Information Center

    MacDonald, Dougal

    This study explored the usefulness of an approach to science instruction which specifically considered children's spontaneous conceptions about natural phenomena. The aim of the instruction was the development of conceptual understanding. The instructional approach involved diagnosing children's spontaneous conceptions, making them aware of their…

  5. A systems approach to the management of large projects: Review of NASA experience with societal implications

    NASA Technical Reports Server (NTRS)

    Vaccaro, M. J.

    1973-01-01

    The application of the NASA type management approach to achieve objectives in other fields is considered. The NASA management outlook and the influences of the NASA environment are discussed along with project organization and management, and applications to socio-economic projects.

  6. Engaging a New Generation of Graduates

    ERIC Educational Resources Information Center

    Shaw, Sue; Fairhurst, David

    2008-01-01

    Purpose: The purpose of this paper is to explore the concept of generational difference and reflect on how this might impact on organisational approaches to graduate development. Design/methodology/approach: The paper explores the characteristics of Generation Y graduates and the implications of their entry into the workplace for organisations'…

  7. Identity Constructions in Bilingual Advertising: A Critical-Cognitive Approach

    ERIC Educational Resources Information Center

    Li, Songqing

    2017-01-01

    Does English always play an important role in constructing identities within the multimodal ad? This question has wide-ranging implications for the study of identity constructions in bilingual advertising in particular, and for bilingualism and multilingualism generally. This article presents a critical-cognitive approach that is an evidence-based…

  8. Designing for the ISD Life Cycle.

    ERIC Educational Resources Information Center

    Wallace, Guy W.; Hybert, Peter R.; Smith, Kelly R.; Blecke, Brian D.

    2002-01-01

    Outlines the recent criticisms of traditional ISD (Instructional Systems Design) and discusses the implications that impact the life cycle costs of T&D (Training and Development) projects and their ROI (Return On Investment) potential. Describes a modified approach to ISD which mimics the modular approach of systems engineering design.…

  9. A Constructive Development Approach to Assessing Variations within a Community College Population

    ERIC Educational Resources Information Center

    Boyer, Timothy R.

    2007-01-01

    This study utilized a constructive-developmental approach to accomplish 3 purposes: to create a developmental stage profile for a population of students attending a single community college, to analyze variations within and between subpopulations, and to explore the implications for administrators and planners seeking to provide supportive…

  10. CES--Cultural, Experiential, Skill Building: The Cognitive Foundation.

    ERIC Educational Resources Information Center

    Rheams, Annie E.; Gallagher, Maureen

    1995-01-01

    Critiques the assimilation strategy and the hero-heroine-ritual approach to multicultural education, and offers a third model, the Cultural, Experiential, Skill Building (CES) approach, as an alternative for teacher training. Effects of the CES model on potential teachers and the implications for teacher training are addressed. (GR)

  11. Three Views of Systems Theories and Their Implications for Sustainability Education

    ERIC Educational Resources Information Center

    Porter, Terry; Cordoba, Jose

    2009-01-01

    Worldwide, there is an emerging interest in sustainability and sustainability education. A popular and promising approach is the use of systems thinking. However, the systems approach to sustainability has neither been clearly defined nor has its practical application followed any systematic rigor, resulting in confounded and underspecified…

  12. Psychological Science, Talent Development, and Educational Advocacy: Lost in Translation?

    ERIC Educational Resources Information Center

    Robinson, Ann

    2012-01-01

    The talent development approach to the conceptualization of giftedness has historical precedent in the field. Examples of large-scale and longitudinal research studies from previous decades guided by the talent development approach are provided as illustrations. The implications of focusing on domain-specific talents in academics, the arts and…

  13. Exploring Genetic Attributions Underlying Radiotherapy-Induced Fatigue in Prostate Cancer Patients.

    PubMed

    Hashemi, Sepehr; Fernandez Martinez, Juan Luis; Saligan, Leorey; Sonis, Stephen

    2017-09-01

    Despite numerous proposed mechanisms, no definitive pathophysiology underlying radiotherapy-induced fatigue (RIF) has been established. However, the dysregulation of a set of 35 genes was recently validated to predict development of fatigue in prostate cancer patients receiving radiotherapy. To hypothesize novel pathways, and provide genetic targets for currently proposed pathways implicated in RIF development through analysis of the previously validated gene set. The gene set was analyzed for all phenotypic attributions implicated in the phenotype of fatigue. Initially, a "directed" approach was used by querying specific fatigue-related sub-phenotypes against all known phenotypic attributions of the gene set. Then, an "undirected" approach, reviewing the entirety of the literature referencing the 35 genes, was used to increase analysis sensitivity. The dysregulated genes attribute to neural, immunological, mitochondrial, muscular, and metabolic pathways. In addition, certain genes suggest phenotypes not previously emphasized in the context of RIF, such as ionizing radiation sensitivity, DNA damage, and altered DNA repair frequency. Several genes also associated with prostate cancer depression, possibly emphasizing variable radiosensitivity by RIF-prone patients, which may have palliative care implications. Despite the relevant findings, many of the 35 RIF-predictive genes are poorly characterized, warranting their investigation. The implications of herein presented RIF pathways are purely theoretical until specific end-point driven experiments are conducted in more congruent contexts. Nevertheless, the presented attributions are informative, directing future investigation to definitively elucidate RIF's pathoetiology. This study demonstrates an arguably comprehensive method of approaching known differential expression underlying a complex phenotype, to correlate feasible pathophysiology. Copyright © 2017 American Academy of Hospice and Palliative Medicine. All rights reserved.

  14. Methodological issues and recommendations for systematic reviews of prognostic studies: an example from cardiovascular disease.

    PubMed

    Dretzke, Janine; Ensor, Joie; Bayliss, Sue; Hodgkinson, James; Lordkipanidzé, Marie; Riley, Richard D; Fitzmaurice, David; Moore, David

    2014-12-03

    Prognostic factors are associated with the risk of future health outcomes in individuals with a particular health condition. The prognostic ability of such factors is increasingly being assessed in both primary research and systematic reviews. Systematic review methodology in this area is continuing to evolve, reflected in variable approaches to key methodological aspects. The aim of this article was to (i) explore and compare the methodology of systematic reviews of prognostic factors undertaken for the same clinical question, (ii) to discuss implications for review findings, and (iii) to present recommendations on what might be considered to be 'good practice' approaches. The sample was comprised of eight systematic reviews addressing the same clinical question, namely whether 'aspirin resistance' (a potential prognostic factor) has prognostic utility relative to future vascular events in patients on aspirin therapy for secondary prevention. A detailed comparison of methods around study identification, study selection, quality assessment, approaches to analysis, and reporting of findings was undertaken and the implications discussed. These were summarised into key considerations that may be transferable to future systematic reviews of prognostic factors. Across systematic reviews addressing the same clinical question, there were considerable differences in the numbers of studies identified and overlap between included studies, which could only partially be explained by different study eligibility criteria. Incomplete reporting and differences in terminology within primary studies hampered study identification and selection process across reviews. Quality assessment was highly variable and only one systematic review considered a checklist for studies of prognostic questions. There was inconsistency between reviews in approaches towards analysis, synthesis, addressing heterogeneity and reporting of results. Different methodological approaches may ultimately affect the findings and interpretation of systematic reviews of prognostic research, with implications for clinical decision-making.

  15. Beyond Compliance Checking: A Situated Approach to Visual Research Ethics.

    PubMed

    Lenette, Caroline; Botfield, Jessica R; Boydell, Katherine; Haire, Bridget; Newman, Christy E; Zwi, Anthony B

    2018-03-19

    Visual research methods like photography and digital storytelling are increasingly used in health and social sciences research as participatory approaches that benefit participants, researchers, and audiences. Visual methods involve a number of additional ethical considerations such as using identifiable content and ownership of creative outputs. As such, ethics committees should use different assessment frameworks to consider research protocols with visual methods. Here, we outline the limitations of ethics committees in assessing projects with a visual focus and highlight the sparse knowledge on how researchers respond when they encounter ethical challenges in the practice of visual research. We propose a situated approach in relation to visual methodologies that encompasses a negotiated, flexible approach, given that ethical issues usually emerge in relation to the specific contexts of individual research projects. Drawing on available literature and two case studies, we identify and reflect on nuanced ethical implications in visual research, like tensions between aesthetics and research validity. The case studies highlight strategies developed in-situ to address the challenges two researchers encountered when using visual research methods, illustrating that some practice implications are not necessarily addressed using established ethical clearance procedures. A situated approach can ensure that visual research remains ethical, engaging, and rigorous.

  16. Acute T-2 Intoxication: Physiologic Consequences and New Therapeutic Approaches

    DTIC Science & Technology

    1983-08-01

    Trichothecene mycotoxins have been implicated in both naturally oc- curring diseases and chemical attacks on civilian and military personnel. Yet...have been implicated in severe, naturally occurring, potentially fatal diseases of both man and animals following ingestion of contaminated grains...underscoring the nature of the TRM-Induced cArdioexcltation. In contrpst to the beneficial effects of TR14, nalo-one wam withotit effect on either blood

  17. Research & market strategy: how choice of drug discovery approach can affect market position.

    PubMed

    Sams-Dodd, Frank

    2007-04-01

    In principal, drug discovery approaches can be grouped into target- and function-based, with the respective aims of developing either a target-selective drug or a drug that produces a specific biological effect irrespective of its mode of action. Most analyses of drug discovery approaches focus on productivity, whereas the strategic implications of the choice of drug discovery approach on market position and ability to maintain market exclusivity are rarely considered. However, a comparison of approaches from the perspective of market position indicates that the functional approach is superior for the development of novel, innovative treatments.

  18. Thought and Creation in Contemporary Education: Theoretical Approaches and Practical Suggestions

    ERIC Educational Resources Information Center

    Cupertino, Christina; Arantes, Denise R. B.; Melcher, Mariangela F.

    2016-01-01

    This article discusses the role of creation and thought in contemporary life, education and, in particular, gifted education. Beginning with traditional approaches to creativity, some implications of diverse ways of understanding these two human activities in education are discussed, and reflections upon ways in which the particular concepts of…

  19. On the Legal Issues of Teaching Evolution in Public Schools

    ERIC Educational Resources Information Center

    Hermann, Ronald S.

    2013-01-01

    In order to effectively teach evolution to all students, even those resistant to learning evolution, science teachers may question the extent to which religion can legally be discussed in the public high school science classroom. Evolution is taught from a variety of approaches, each of which has legal implications. Four approaches to teaching…

  20. An Interpersonal Psychotherapy Approach to Counseling Student Athletes: Clinical Implications of Athletic Identity

    ERIC Educational Resources Information Center

    Heird, Emily Benton; Steinfeldt, Jesse A.

    2013-01-01

    Research has shown that disruptive circumstances in an athlete's career (temporary injury, permanent injury, retirement) can pose significant difficulties, especially if the athlete has developed a salient athletic identity at the expense of a multidimensional self-concept. The authors present an interpersonal psychotherapy approach to case…

  1. Social-Ecological Resilience and Environmental Education: Synopsis, Application, Implications

    ERIC Educational Resources Information Center

    Plummer, Ryan

    2010-01-01

    The resilience approach is rooted in ecology and is being advanced as a means to understand change in social-ecological systems. How can resilience be applied to understanding change in social systems, including in environmental education? In probing this question the main resilience approaches are described, the manner in which they may be…

  2. Multiple Knowledges for Agricultural Production: Implications for the Development of Conservation Agriculture in Kenya and Uganda

    ERIC Educational Resources Information Center

    Moore, Keith M.; Lamb, Jennifer N.; Sikuku, Dominic Ngosia; Ashilenje, Dennis S.; Laker-Ojok, Rita; Norton, Jay

    2014-01-01

    Purpose: This article investigates the extent of multiple knowledges among smallholders and connected non-farm agents around Mount Elgon in Kenya and Uganda in order to build the communicative competence needed to scale up conservation agriculture production systems (CAPS). Design/methodology/approach: Our methodological approach examines local…

  3. Integrated Education in Conflicted Societies: Is There a Need for New Theoretical Language?

    ERIC Educational Resources Information Center

    Zembylas, Michalinos; Bekerman, Zvi

    2013-01-01

    This article takes on the issue of "integrated education" in conflicted societies and engages in a deeper analysis of its dominant theoretical concepts, approaches, and implications. This analysis suggests that the theoretical language that drives current approaches of integrated education may unintentionally be complicit to the project…

  4. A Case Study on the Impact of Teacher Mathematical Knowledge on Pedagogical Practices

    ERIC Educational Resources Information Center

    Hughes, Sally

    2016-01-01

    This study explores the implications for mathematical knowledge and pedagogical practices of primary teachers in Papua New Guinea making a shift from a transmission approach to a connectionist approach to teaching mathematics. The research participants were engaged in a professional development program designed to support the teaching and learning…

  5. Community Reinforcement and the Dissemination of Evidence-Based Practice: Implications for Public Policy

    ERIC Educational Resources Information Center

    Milford, Jaime L.; Austin, Julia L.; Smith, Jane Ellen

    2007-01-01

    The Community Reinforcement Approach (CRA) and Community Reinforcement and Family Training (CRAFT) are both highly effective and empirically validated psychosocial approaches to the treatment of addictions whose unique designs may help achieve certain public health objectives. Literature will be reviewed to examine the potential impact of CRA and…

  6. The Fifth Generation and Training Strategies

    ERIC Educational Resources Information Center

    Ennals, Richard

    2008-01-01

    Fifth Generation computers should not simply be regarded as an enhancement of current computer technology: the intention is that a fresh approach should be taken to computer science and to the use of computers. The argument of this paper is that the fresh approach must encompass education and training, with implications that extend far beyond the…

  7. Editing Distance Education Materials. Knowledge Series.

    ERIC Educational Resources Information Center

    Swales, Christine

    Distance education (DE) materials take a learner-centered approach rather than the traditionally content-centered approach of textbooks. This fact has several implications for the editing of DE materials. The role of the editor within the DE organization will depend on the organization's size and structure. The basic features of the DE program or…

  8. The TEACH Method: An Interactive Approach for Teaching the Needs-Based Theories Of Motivation

    ERIC Educational Resources Information Center

    Moorer, Cleamon, Jr.

    2014-01-01

    This paper describes an interactive approach for explaining and teaching the Needs-Based Theories of Motivation. The acronym TEACH stands for Theory, Example, Application, Collaboration, and Having Discussion. This method can help business students to better understand and distinguish the implications of Maslow's Hierarchy of Needs,…

  9. Disordered Attention: Implications for Understanding and Treating Internalizing and Externalizing Disorders in Childhood

    ERIC Educational Resources Information Center

    Racer, Kristina Hiatt; Dishion, Thomas J.

    2012-01-01

    In this article, we present evidence that disorders of attention are present in wide range of psychological disorders, and that the appropriate assessment and treatment of these attention difficulties can be an important adjunct to traditional therapeutic approaches. We review approaches to attention training in some detail and discuss how…

  10. A Critical Comparison of Classical and Domain Theory: Some Implications for Character Education

    ERIC Educational Resources Information Center

    Keefer, Matthew Wilks

    2006-01-01

    Contemporary approaches to moral education are influenced by the "domain theory" approach to understanding moral development (Turiel, 1983; 1998; Nucci, 2001). Domain theory holds there are distinct conventional, personal and moral domains; each constituting a cognitive "structured-whole" with its own normative source and sphere of influence. One…

  11. Reader Response in Secondary Settings: Increasing Comprehension through Meaningful Interactions with Literary Texts

    ERIC Educational Resources Information Center

    Woodruff, Amanda H.; Griffin, Robert A.

    2017-01-01

    A fresh look at the reader response theory to enhance student comprehension through meaningful interactions with literature, this paper explores the instructional implications of a reader response approach in secondary classrooms and examines its role in fostering students' critical reading and thinking skills. The approach promotes transaction…

  12. Managing Skills and Knowledge Using Online Tools

    ERIC Educational Resources Information Center

    Waller, Dave; Holland, Tom

    2009-01-01

    Purpose: This paper aims to explore a structured approach to measuring skills and knowledge, and to outline how such an approach can be beneficial for improving performance and supporting strategy. It also seeks to examine how online tools can help with this process and to look at implications for the wider UK and European skills development…

  13. The New Epistemology and the Milan Approach: Feminist and Sociopolitical Considerations.

    ERIC Educational Resources Information Center

    MacKinnon, Laurie Katherine; Miller, Dusty

    1987-01-01

    Explores the sociopolitical implications of the new epistemology and the Milan approach, concluding that, while second order cybernetics has greater potential to incorporate a radical social analysis, it has, nevertheless, failed to do so. The application of second order cybernetics in family therapy appears to be constrained by the sociopolitical…

  14. Are Approaches to Learning in Kindergarten Associated with Academic and Social Competence Similarly?

    ERIC Educational Resources Information Center

    Razza, Rachel A.; Martin, Anne; Brooks-Gunn, Jeanne

    2015-01-01

    Background: Approaches to learning (ATL) is a key domain of school readiness with important implications for children's academic trajectories. Interestingly, however, the impact of early ATL on children's social competence has not been examined. Objective: This study examines associations between children's ATL at age 5 and academic achievement…

  15. Essays on New Careers; Social Implications for Adult Educators.

    ERIC Educational Resources Information Center

    Riessman, Frank; And Others

    These essays concentrate on the challenge that adult education faces in helping the urban poor develop meaningful paraprofessional careers in the human services. In one essay, the reformist approach to improving access to credentials is compared with the radical approach, which questions the validity of the credentials process as well as its…

  16. The Paradigm Revolution in Inquiry: Implications for Vocational Research and Development.

    ERIC Educational Resources Information Center

    Guba, Egon G.

    While the rationalistic approach traditionally employed in research and development efforts in the social sciences may be the best method of inquiry to use in the physical sciences, social scientists, and, more particularly, vocational education researchers, would do better to adopt a naturalistic method of research. The naturalist approach to…

  17. Dividing Attention within and between Hemispheres: Testing a Multiple Resources Approach to Limited-Capacity Information Processing.

    ERIC Educational Resources Information Center

    Friedman, Alinda; And Others

    1982-01-01

    Two experiments tested the limiting case of a multiple resources approach to resource allocation in information processing. Results contradict a single-capacity model, supporting the idea that the hemispheres' resource supplies are independent and have implications for both cerebral specialization and divided attention issues. (Author/PN)

  18. Integrating Genetic, Psychopharmacological and Neuroimaging Studies: A Converging Methods Approach to Understanding the Neurobiology of ADHD

    ERIC Educational Resources Information Center

    Durston, Sarah; Konrad, Kerstin

    2007-01-01

    This paper aims to illustrate how combining multiple approaches can inform us about the neurobiology of ADHD. Converging evidence from genetic, psychopharmacological and functional neuroimaging studies has implicated dopaminergic fronto-striatal circuitry in ADHD. However, while the observation of converging evidence from multiple vantage points…

  19. Anger Is an Approach-Related Affect: Evidence and Implications

    ERIC Educational Resources Information Center

    Carver, Charles S.; Harmon-Jones, Eddie

    2009-01-01

    The authors review a range of evidence concerning the motivational underpinnings of anger as an affect, with particular reference to the relationship between anger and anxiety or fear. The evidence supports the view that anger relates to an appetitive or approach motivational system, whereas anxiety relates to an aversive or avoidance motivational…

  20. Social Exclusion and Inequality in Higher Education in China: A Capability Perspective

    ERIC Educational Resources Information Center

    Wang, Li

    2011-01-01

    Following calls for further research in education inequality beyond input and output measures, especially with a qualitative approach, and building on the implications of capability deprivation on equality (Unterhalter, 2003a,b), we extend the findings of Sen's (1979, 1990, 1992, 2000) capability approach to higher education (HE). This article…

  1. Exploring leadership in the context of dentistry in the UK.

    PubMed

    Willcocks, Stephen George

    2016-05-03

    Purpose The purpose of this paper is to explore selective leadership approaches in the context of dentistry in the UK. Design/methodology/approach This is a conceptual paper utilising published sources from relevant literature about leadership theory and practice and the policy background to dentistry in the UK. Findings This paper suggests that there is merit in identifying and applying an eclectic mix of leadership theory to the case of dentistry. It offers insight into individual aspects of the leadership role for dentists and applies this to the dental context. It also contrasts these individual approaches with shared leadership and suggests this may also be relevant to dentistry. It highlights the fact that leadership will be of growing concern for dentistry in the light of recent policy changes. Research limitations/implications This paper points out that there are developmental implications depending on the particular approach taken. It argues that leadership development will become increasingly important in dentistry in the UK. Originality/value This paper addresses a topic that has so far received limited attention in the literature.

  2. An integrative discourse perspective on positive leadership in public health care.

    PubMed

    Pietiläinen, Ville; Salmi, Ilkka

    2017-02-06

    Purpose This study aims to take a discursive view on positive leadership (PL). A positive approach has gained momentum in recent years as appropriate leadership practices are implemented in organizations. Despite the turn toward discursive approaches in organization studies, there is insufficient evidence supporting PL as a socially constructed experience. Design/methodology/approach The present study addresses an integrative discourse perspective for capturing the PL concept as a social process within the public health-care context. Findings Four meanings of PL are highlighted: role-taking, servicing, balancing and deciphering. Research limitations/implications The meanings shift the emphasis of certain PL definitions to a contextual interpretation. For scholars, the perspective demonstrates a multidimensional process approach in the desired organizational context as a counterbalance to one unanimously agreed-upon PL definition. Practical implications For leaders, an integrative discourse perspective offers tools for comprehending PL as a process: how to identify, negotiate and reconcile various PL meanings. Originality/value An integrative discourse perspective provides a novel perspective capturing the PL concept within the public health-care field.

  3. Theory-based approaches to understanding public emergency preparedness: implications for effective health and risk communication.

    PubMed

    Paek, Hye-Jin; Hilyard, Karen; Freimuth, Vicki; Barge, J Kevin; Mindlin, Michele

    2010-06-01

    Recent natural and human-caused disasters have awakened public health officials to the importance of emergency preparedness. Guided by health behavior and media effects theories, the analysis of a statewide survey in Georgia reveals that self-efficacy, subjective norm, and emergency news exposure are positively associated with the respondents' possession of emergency items and their stages of emergency preparedness. Practical implications suggest less focus on demographics as the sole predictor of emergency preparedness and more comprehensive measures of preparedness, including both a person's cognitive stage of preparedness and checklists of emergency items on hand. We highlight the utility of theory-based approaches for understanding and predicting public emergency preparedness as a way to enable more effective health and risk communication.

  4. The Implications of Ecologically Based Assessment for Primary Prevention with Indigenous Youth Populations

    PubMed Central

    Okamoto, Scott K.; LeCroy, Craig Winston; Tann, Sheila S.; Rayle, Andrea Dixon; Kulis, Stephen; Dustman, Patricia; Berceli, David

    2011-01-01

    This paper describes a five-stage approach toward conducting an ecologically based assessment with Indigenous youth populations, and the implications of this approach for the development and implementation of culturally grounded prevention interventions. A description of a pilot study funded by the National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA) focused on drug use and American Indian youth is presented as one model for operationalizing ecologically based assessment with Indigenous youth populations, and issues related to translating the pilot study into a prevention intervention are discussed. This paper suggests that ecologically based assessment can serve as a foundation for culturally grounded prevention interventions, promoting the social and ecological validity of those interventions. PMID:16534658

  5. Climate Change, Public Health, and Policy: A California Case Study.

    PubMed

    Ganesh, Chandrakala; Smith, Jason A

    2018-04-01

    Anthropogenic activity will bring immediate changes and disruptions to the global climate with accompanying health implications. Although policymakers and public health advocates are beginning to acknowledge the health implications of climate change, current policy approaches are lagging behind. We proposed that 4 key policy principles are critical to successful policymaking in this arena: mainstreaming, linking mitigation and adaptation policy, applying population perspectives, and coordination. We explored California's progress in addressing the public health challenges of climate change in the San Joaquin Valley as an example. We discussed issues of mental health and climate change, and used the San Joaquin Valley of California as an example to explore policy approaches to health issues and climate change. The California experience is instructive for other jurisdictions.

  6. Apprentissage de l'expression orale en autonomie. Implications de l'approche fonctionelle (Learning Oral Expression in Independent Study. Implications of the Functional Approach). Melanges pedagogiques.

    ERIC Educational Resources Information Center

    Abe, D.; And Others

    Within the CRAPEL autonomous learning scheme, modular material is being developed for communicative oral expression. The purpose of this material is twofold: (1) to enable the learner to define his or her own needs in communicative terms, that is, to analyse a situation in terms of communicative acts needed in a given situation, the relationships…

  7. Water for electricity in India: A multi-model study of future challenges and linkages to climate change mitigation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Srinivasan, Shweta; Kholod, Nazar; Chaturvedi, Vaibhav

    This paper provides projections of water withdrawals and consumption for electricity generation in India through 2050. Based on the results from five energy-economic modeling teams, the paper explores the implications of economic growth, power plant cooling policies, and electricity CO 2 emissions reductions on water withdrawals and consumption. To understand how different modeling approaches derive different results for energy-water interactions, the five teams used harmonized assumptions regarding economic and population growth, the distribution of power plants by cooling technologies, and withdrawals and consumption intensities. The multi-model study provides robust results regarding the different but potentially complementary implications of cooling technologymore » policies and efforts to reduce CO 2 emissions. The water implications of CO 2 emissions reductions depend critically on the approach to these reductions. Focusing on wind and solar power reduces consumption and withdrawals, a focus on nuclear power increases both, and a focus on hydroelectric power could increase consumptive losses through evaporation. Policies focused specifically on cooling water can have substantial and complementary impacts.« less

  8. Shifting from presumptive to test-based management of malaria - technical basis and implications for malaria control in Ghana.

    PubMed

    Baiden, F; Malm, K; Bart-Plange, C; Hodgson, A; Chandramohan, D; Webster, J; Owusu-Agyei, S

    2014-06-01

    The presumptive approach was the World Health Organisation (WHO) recommended to the management of malaria for many years and this was incorporated into syndromic guidelines such as the Integrated Management of Childhood Illnesses (IMCI). In early 2010 however, WHO issued revised treatment guidelines that call for a shift from the presumptive to the test-based approach. Practically, this implies that in all suspected cases, the diagnosis of uncomplicated malaria should be confirmed using rapid test before treatment is initiated. This revision effectively brings to an end an era of clinical practice that span several years. Its implementation has important implications for the health systems in malaria-endemic countries. On the basis of research in Ghana and other countries, and evidence from program work, the Ghana National Malaria Control Program has issued revised national treatment guidelines that call for implementation of test-based management of malaria in all cases, and across all age groups. This article reviews the evidence and the technical basis for the shift to test-based management and examines the implications for malaria control in Ghana.

  9. Water for electricity in India: A multi-model study of future challenges and linkages to climate change mitigation

    DOE PAGES

    Srinivasan, Shweta; Kholod, Nazar; Chaturvedi, Vaibhav; ...

    2017-05-05

    This paper provides projections of water withdrawals and consumption for electricity generation in India through 2050. Based on the results from five energy-economic modeling teams, the paper explores the implications of economic growth, power plant cooling policies, and electricity CO 2 emissions reductions on water withdrawals and consumption. To understand how different modeling approaches derive different results for energy-water interactions, the five teams used harmonized assumptions regarding economic and population growth, the distribution of power plants by cooling technologies, and withdrawals and consumption intensities. The multi-model study provides robust results regarding the different but potentially complementary implications of cooling technologymore » policies and efforts to reduce CO 2 emissions. The water implications of CO 2 emissions reductions depend critically on the approach to these reductions. Focusing on wind and solar power reduces consumption and withdrawals, a focus on nuclear power increases both, and a focus on hydroelectric power could increase consumptive losses through evaporation. Policies focused specifically on cooling water can have substantial and complementary impacts.« less

  10. Making history critical.

    PubMed

    Learmonth, Mark

    2017-08-21

    Purpose The purpose of this paper is to explore a possible discursive history of National Health Service (NHS) "management" (with management, for reasons that will become evident, very much in scare quotes). Such a history is offered as a complement, as well as a counterpoint, to the more traditional approaches that have already been taken to the history of the issue. Design/methodology/approach Document analysis and interviews with UK NHS trust chief executives. Findings After explicating the assumptions of the method it suggests, through a range of empirical sources that the NHS has undergone an era of administration, an era of management and an era of leadership. Research limitations/implications The paper enables a recasting of the history of the NHS; in particular, the potential for such a discursive history to highlight the interests supported and denied by different representational practices. Practical implications Today's so-called leaders are leaders because of conventional representational practices - not because of some essence about what they really are. Social implications New ideas about the nature of management. Originality/value The value of thinking in terms of what language does - rather than what it might represent.

  11. Developing the Critical Intercultural Class-Space: Theoretical Implications and Pragmatic Applications of Critical Intercultural Communication Pedagogy

    ERIC Educational Resources Information Center

    Sobre, Miriam Shoshana

    2017-01-01

    Teaching intercultural communication presents pedagogical challenges due to the breadth and depth of the discipline and its recent critical turn. Teaching it with a social justice mission, and guiding students to understand critical and postcolonial approaches to its practice, requires complex and multifaceted approaches so as not to oppress or…

  12. Revisiting the Whole-School Approach to Bullying: Really Looking at the Whole School

    ERIC Educational Resources Information Center

    Richard, Jacques F.; Schneider, Barry H.; Mallet, Pascal

    2012-01-01

    The whole-school approach to bullying prevention is predicated on the assumption that bullying is a systemic problem, and, by implication, that intervention must be directed at the entire school context rather than just at individual bullies and victims. Unfortunately, recent meta-analyses that have looked at various bullying programs from many…

  13. Connections between Modes of Thinking and Learning Approaches: Implications for Education and Research

    ERIC Educational Resources Information Center

    Önen, Emine

    2015-01-01

    This study aimed to examine connections between modes of thinking and approaches to learning. Participants were 1490 students attending to 9 high schools located in Ankara. The Style of Learning and Thinking-Youth Form and Revised Version of Learning Process Questionnaire were administered to these students. The connections between modes of…

  14. The Strength of the Relation between Performance-Approach and Performance-Avoidance Goal Orientations: Theoretical, Methodological, and Instructional Implications

    ERIC Educational Resources Information Center

    Linnenbrink-Garcia, Lisa; Middleton, Michael J.; Ciani, Keith D.; Easter, Matthew A.; O'Keefe, Paul A.; Zusho, Akane

    2012-01-01

    In current research on achievement goal theory, most researchers differentiate between performance-approach and performance-avoidance goal orientations. Evidence from prior research and from several previously published data sets is used to highlight that the correlation is often rather large, with a number of studies reporting correlations above…

  15. Effectiveness of a Blended E-Learning Cooperative Approach in an Egyptian Teacher Education Programme

    ERIC Educational Resources Information Center

    EL-Deghaidy, Heba; Nouby, Ahmed

    2008-01-01

    This paper describes the results and implications of a study into the effectiveness of a blended e-learning cooperative approach (BeLCA) on Pre-Service Teacher's (PST) achievement, attitudes towards e-learning and cooperativeness. Quantitative and qualitative methodologies were used with participants of the study. Twenty-six science PSTs, enrolled…

  16. Are Cortical Motor Maps Based on Body Parts or Coordinated Actions? Implications for Embodied Semantics

    ERIC Educational Resources Information Center

    Fernandino, Leonardo; Iacoboni, Marco

    2010-01-01

    The embodied cognition approach to the study of the mind proposes that higher order mental processes such as concept formation and language are essentially based on perceptual and motor processes. Contrary to the classical approach in cognitive science, in which concepts are viewed as amodal, arbitrary symbols, embodied semantics argues that…

  17. New Frontiers: Exploring the Power and Possibilities of the Unconference as a Transformative Approach to Faculty Development

    ERIC Educational Resources Information Center

    Hale, Enoch; Bessette, Lee Skallerup

    2016-01-01

    In the spirit of exploration, this paper discusses the what, why and how of unconferencing and explores its implications as a transformative approach to faculty development in higher education. The authors define an unconference faculty development experience as: a less-structured opportunity for participants to learn and grow by sharing…

  18. Introducing the Improved Heaviside Approach to Partial Fraction Decomposition to Undergraduate Students: Results and Implications from a Pilot Study

    ERIC Educational Resources Information Center

    Man, Yiu-Kwong

    2012-01-01

    Partial fraction decomposition is a useful technique often taught at senior secondary or undergraduate levels to handle integrations, inverse Laplace transforms or linear ordinary differential equations, etc. In recent years, an improved Heaviside's approach to partial fraction decomposition was introduced and developed by the author. An important…

  19. "Reflexivity Is Kicking Our Asses": Tensions in Foregrounding Photographs in a Multimodal Ethnographic Analysis of Participation

    ERIC Educational Resources Information Center

    Chaffee, Rachel; Luehmann, April Lynn; Henderson, Joseph

    2016-01-01

    Bringing multimodal and ethnographic approaches together, this paper seeks to identify key considerations, limitations, and implications of using photographs as primary data. We offer a concrete example of an approach that capitalizes on a systematic look at how different modes work together to foreground unique aspects of participation, while…

  20. Psychological Needs, Engagement, and Work Intentions: A Bayesian Multi-Measurement Mediation Approach and Implications for HRD

    ERIC Educational Resources Information Center

    Shuck, Brad; Zigarmi, Drea; Owen, Jesse

    2015-01-01

    Purpose: The purpose of this study was to empirically examine the utility of self-determination theory (SDT) within the engagement-performance linkage. Design/methodology/approach: Bayesian multi-measurement mediation modeling was used to estimate the relation between SDT, engagement and a proxy measure of performance (e.g. work intentions) (N =…

  1. The Search for an Effective Clinical Behavior Analysis: The Nonlinear Thinking of Israel Goldiamond

    ERIC Educational Resources Information Center

    Layng, T. V. Joe

    2009-01-01

    This paper has two purposes; the first is to reintroduce Goldiamond's constructional approach to clinical behavior analysis and to the field of behavior analysis as a whole, which, unfortunately, remains largely unaware of his nonlinear functional analysis and its implications. The approach is not simply a set of clinical techniques; instead it…

  2. Evaluating the sources of potential migrant species: implications under climate change

    Treesearch

    Ines Ibanez; James S. Clark; Michael C. Dietze

    2008-01-01

    As changes in climate become more apparent, ecologists face the challenge of predicting species responses to the new conditions. Most forecasts are based on climate envelopes (CE), correlative approaches that project future distributions on the basis of the current climate often assuming some dispersal lag. One major caveat with this approach is that it ignores the...

  3. Application of the riverine ecosystem synthesis (RES) and the functional process zone (FPZ) approach to EPA environmental mission tasks for rivers

    EPA Science Inventory

    The shift to watershed management of rivers from a more reach-based approach has had far-reaching implications for the way we characterize and classify rivers and then use this information to understand and manage biodiversity, ecological functions, and ecosystem services in rive...

  4. Practical Implications of a Constructivist Approach to EFL Teaching in a Higher Education Context

    ERIC Educational Resources Information Center

    Iglesias Xamani, Montserrat

    2013-01-01

    Traditional pedagogical approaches may not be the best way to cater for the specific needs of learners in higher education settings, particularly those of university students with special expectations and professional prospects. The question of enhancing language learning awareness as a means of fostering the acquisition of a foreign language…

  5. Psychological Contracts and Their Implications for Commitment: A Feature-Based Approach

    ERIC Educational Resources Information Center

    McInnis, Kate J.; Meyer, John P.; Feldman, Susan

    2009-01-01

    Two studies were conducted to examine the link between employee perceptions of the psychological contract and their affective and normative commitments to the organization. The authors adapt a new approach to the study of psychological contracts by developing a generalizable measure of "contract features" (e.g., scope; time frame). In Study 1…

  6. What's in a Domain: Understanding How Students Approach Questioning in History and Science

    ERIC Educational Resources Information Center

    Portnoy, Lindsay Blau

    2013-01-01

    During their education, students are presented with information across a variety of academic domains. How students ask questions as they learn has implications for understanding, retention, and problem solving. The current research investigates the influence of age and prior knowledge on the ways students approach questioning across history and…

  7. What's in a Domain: Understanding How Students Approach Questioning in History and Science

    ERIC Educational Resources Information Center

    Portnoy, Lindsay Blau; Rabinowitz, Mitchell

    2014-01-01

    How students ask questions as they learn has implications for understanding, retention, and problem solving. The current research investigates the influence of domain, age, and previous experience with content on the ways students approach questioning across history and science texts. In 3 experiments, 3rd-, 8th-, and 10th-grade students in large…

  8. Student-Centredness: The Link between Transforming Students and Transforming Ourselves

    ERIC Educational Resources Information Center

    Blackie, Margaret A. L.; Case, Jennifer M.; Jawitz, Jeff

    2010-01-01

    It is widely accepted in the higher education literature that a student-centred approach is pedagogically superior to a teacher-centred approach. In this paper, we explore the notion of student-centredness as a threshold concept and the implications this might have for academic staff development. We argue that the term student-centred in the…

  9. Results from an Exploratory Study of Sun Protection Practice: Implications for the Design of Health Promotion Messages

    ERIC Educational Resources Information Center

    Eadie, Douglas; MacAskill, Susan

    2007-01-01

    Purpose: The primary aim of the research reported here is to provide strategic guidance for the development of a national communication strategy to improve sun protection practice amongst young people. Design/methodology/approach: The research adopted an exploratory approach, employing qualitative focus groups to represent three population groups,…

  10. Reconstructive Memory: A Non-Traditional Approach to Assessing Young Children's Intelligence.

    ERIC Educational Resources Information Center

    Cocking, Rodney R.; And Others

    Implications are discussed for new instrument development by way of a methodological study which used a task allowing one to focus upon: (1) a non-verbal approach; (2) memory functions; (3) a variety of mnemonics that children use in information retrieval; and (4) a non-traditional procedure supported by psychological and developmental research. A…

  11. Language-in-Education Policy in Low-Income, Postcolonial Contexts: Towards a Social Justice Approach

    ERIC Educational Resources Information Center

    Tikly, Leon

    2016-01-01

    The article considers how language-in-education policy in low-income, postcolonial countries may be better understood from a social justice perspective and some of the implications for policy, practice and research that arise from this. The article starts with a critical overview of the two dominant approaches towards conceptualising…

  12. Life course approach in social epidemiology: an overview, application and future implications.

    PubMed

    Cable, Noriko

    2014-01-01

    The application of the life course approach to social epidemiology has helped epidemiologists theoretically examine social gradients in population health. Longitudinal data with rich contextual information collected repeatedly and advanced statistical approaches have made this challenging task easier. This review paper provides an overview of the life course approach in epidemiology, its research application, and future challenges. In summary, a systematic approach to methods, including theoretically guided measurement of socioeconomic position, would assist researchers in gathering evidence for reducing social gradients in health, and collaboration across individual disciplines will make this task achievable.

  13. The Promise of Tailoring Incentives for Healthy Behaviors

    PubMed Central

    Kullgren, Jeffrey T.; Williams, Geoffrey C.; Resnicow, Kenneth; An, Lawrence C.; Rothberg, Amy; Volpp, Kevin G.; Heisler, Michele

    2017-01-01

    Purpose To describe how tailoring financial incentives for healthy behaviors to employees’ goals, values, and aspirations might improve the efficacy of incentives. Design/methodology/approach We integrate insights from self-determination theory (SDT) with principles from behavioral economics in the design of financial incentives by linking how incentives could help meet an employee’s life goals, values, or aspirations. Findings Tailored financial incentives could be more effective than standard incentives in promoting autonomous motivation necessary to initiate healthy behaviors and sustain them after incentives are removed. Research implications Previous efforts to improve the design of financial incentives have tested different incentive designs that vary the size, schedule, timing, and target of incentives. Our strategy for tailoring incentives builds on strong evidence that difficult behavior changes are more successful when integrated with important life goals and values. We outline necessary research to examine the effectiveness of this approach among at-risk employees. Practical implications Instead of offering simple financial rewards for engaging in healthy behaviors, existing programs could leverage incentives to promote employees’ autonomous motivation for sustained health improvements. Social implications Effective application of these concepts could lead to programs more effective at improving health, potentially at lower cost. Originality/value Our approach for the first time integrates key insights from SDT, behavioral economics, and tailoring to turn an extrinsic reward for behavior change into an internalized, self-sustaining motivator for long-term engagement in risk-reducing behaviors. PMID:29242715

  14. Conceptualising the 'community' as a recipient of money--A critical literature review, and implications for health and inequalities.

    PubMed

    Reynolds, Joanna; Egan, Matt; Renedo, Alicia; Petticrew, Mark

    2015-10-01

    There is increasing attention on how money may bring about positive changes to health, and money-based development approaches are becoming more commonplace at the 'community' level, including in high-income countries. However, little attention has been paid to how the 'community' might be varyingly conceptualised in these scenarios, or to the potential implications of this for interpreting the impacts of such health improvement approaches. This paper presents a critical interpretive review of literature presenting different scenarios from high-income countries in which the 'community' receives money, to explore how 'community' is conceptualised in relation to this process. Some texts gave explicit definitions of 'community', but multiple other conceptualisations were interpreted across all texts, conveyed through the construction of 'problematics', and descriptions of how and why money was given. The findings indicate that the flow of money shapes how conceptualisations of 'community' are produced, and that the implicit power relations and inequalities can construct and privilege particular sets of identities and relationships throughout the process. This highlights implications for approaching public health evaluations of giving money to 'communities', and for better understanding how it might bring about change to health and inequalities, where the 'community' cannot be interpreted merely as a setting or recipient of such an intervention, but something constructed and negotiated through the flow of money itself. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Integrated metatranscriptomics and metaproteomics for the characterization of bacterial microbiota in unfed Ixodes ricinus.

    PubMed

    Hernández-Jarguín, Angélica; Díaz-Sánchez, Sandra; Villar, Margarita; de la Fuente, José

    2018-05-05

    An innovative metaomics approach integrating metatranscriptomics and metaproteomics was used to characterize bacterial communities in the microbiota of the Lyme borreliosis spirochete vector, Ixodes ricinus (Acari: Ixodidae). Whole internal tissues and salivary glands from unfed larvae and female ticks, respectively were used. Reused I. ricinus RNA-sequencing data for metranscriptomics analysis together with metaproteomics provided a better characterization of tick bacterial microbiota by increasing bacteria identification and support for identified bacteria with putative functional implications. The results showed the presence of symbiotic, commensal, soil, environmental, and pathogenic bacteria in the I. ricinus microbiota, including previously unrecognized commensal and soil microorganisms. The results of the metaomics approach may have implications in the characterization of putative mechanisms by which pathogen infection manipulates tick microbiota to facilitate infection. Metaomics approaches integrating different omics datasets would provide a better description of tick microbiota compositions, and insights into tick interactions with microbiota, pathogens and hosts. Copyright © 2018 Elsevier GmbH. All rights reserved.

  16. General patterns of managerial approaches to work motivation: Implications for rehabilitation professionals involved in occupational rehabilitation.

    PubMed

    Murphy, G C; Foreman, P

    1993-03-01

    Calls for rehabilitation counselors to learn more about the world of work have been recently repeated. The validity of these calls is suggested by a group of studies which indicate that the rehabilitation counseling literature has an established emphasis on matters of counseling and adjustment rather than on matters related to behavior in organizations. A survey of rehabilitation counsellors' beliefs about key topics in organizational behavior indicates that their beliefs are often discrepant with those of practicing managers and supervisors. A summary of dominant models of work motivation adopted by managerial workers is presented and some implications for occupational rehabilitation practice identified. Finally, some contemporary literature relevant to managerial approaches to employee motivation are identified and it is suggested that familiarity with this literature could assist rehabilitation practitioners move from a more narrow occupational rehabilitation role to a broader involvement in organizational life via the expansion of the disability management approach in work organizations.

  17. Potential Implications of Approaches to Climate Change on the Clean Water Rule Definition of "Waters of the United States".

    PubMed

    Faust, Derek R; Moore, Matthew T; Emison, Gerald Andrews; Rush, Scott A

    2016-05-01

    The 1972 Clean Water Act was passed to protect chemical, physical, and biological integrity of United States' waters. The U.S. Environmental Protection Agency and U.S. Army Corps of Engineers codified a new "waters of the United States" rule on June 29, 2015, because several Supreme Court case decisions caused confusion with the existing rule. Climate change could affect this rule through connectivity between groundwater and surface waters; floodplain waters and the 100-year floodplain; changes in jurisdictional status; and sea level rise on coastal ecosystems. Four approaches are discussed for handling these implications: (1) "Wait and see"; (2) changes to the rule; (3) use guidance documents; (4) Congress statutorily defining "waters of the United States." The approach chosen should be legally defensible and achieved in a timely fashion to provide protection to "waters of the United States" in proactive consideration of scientifically documented effects of climate change on aquatic ecosystems.

  18. Understanding social forces involved in diabetes outcomes: a systems science approach to quality-of-life research.

    PubMed

    Lounsbury, David W; Hirsch, Gary B; Vega, Chawntel; Schwartz, Carolyn E

    2014-04-01

    The field of quality-of-life (QOL) research would benefit from learning about and integrating systems science approaches that model how social forces interact dynamically with health and affect the course of chronic illnesses. Our purpose is to describe the systems science mindset and to illustrate the utility of a system dynamics approach to promoting QOL research in chronic disease, using diabetes as an example. We build a series of causal loop diagrams incrementally, introducing new variables and their dynamic relationships at each stage. These causal loop diagrams demonstrate how a common set of relationships among these variables can generate different disease and QOL trajectories for people with diabetes and also lead to a consideration of non-clinical (psychosocial and behavioral) factors that can have implications for program design and policy formulation. The policy implications of the causal loop diagrams are discussed, and empirical next steps to validate the diagrams and quantify the relationships are described.

  19. [Ethical principles and approaches to health systems governance research: conceptual and methodological implications].

    PubMed

    Flores, Walter

    2010-01-01

    Governance refers to decision-making processes in which power relationships and actors and institutions' particular interests converge. Situations of consensus and conflict are inherent to such processes. Furthermore, decision-making happens within a framework of ethical principles, motivations and incentives which could be explicit or implicit. Health systems in most Latin-American and Caribbean countries take the principles of equity, solidarity, social participation and the right to health as their guiding principles; such principles must thus rule governance processes. However, this is not always the case and this is where the importance of investigating governance in health systems lies. Making advances in investigating governance involves conceptual and methodological implications. Clarifying and integrating normative and analytical approaches is relevant at conceptual level as both are necessary for an approach seeking to investigate and understand social phenomena's complexity. In relation to methodological level, there is a need to expand the range of variables, sources of information and indicators for studying decision-making aimed to greater equity, health citizenship and public policy efficiency.

  20. Developmental and Contextual Considerations for Adrenal and Gonadal Hormone Functioning During Adolescence: Implications for Adolescent Mental Health

    PubMed Central

    Ruttle, Paula L.; Shirtcliff, Elizabeth A.; Essex, Marilyn J.; Susman, Elizabeth J.

    2014-01-01

    Substantial research has implicated the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes independently in adolescent mental health problems, though this literature remains largely inconclusive. Given the cross-talk between the HPA and HPG axes and their increased activation in adolescence, a dual-axis approach that examines both axes simultaneously is proposed to predict the emergence and persistence of adolescent mental health problems. After briefly orienting readers to HPA and HPG axis functioning, we review the literature examining associations between hormone levels and changes with behavior during adolescence. Then, we provide a review of the literature supporting examination of both axes simultaneously and present the limited research that has taken a dual-axis approach. We propose future directions including consideration of between-person and within-person approaches to address questions of correlated changes in HPA and HPG hormones. Potential moderators are considered to increase understanding of the nuanced hormone–behavior associations during key developmental transitions. PMID:24729154

  1. Human effects on ecological connectivity in aquatic ecosystems: Integrating scientific approaches to support management and mitigation.

    PubMed

    Crook, David A; Lowe, Winsor H; Allendorf, Frederick W; Erős, Tibor; Finn, Debra S; Gillanders, Bronwyn M; Hadwen, Wade L; Harrod, Chris; Hermoso, Virgilio; Jennings, Simon; Kilada, Raouf W; Nagelkerken, Ivan; Hansen, Michael M; Page, Timothy J; Riginos, Cynthia; Fry, Brian; Hughes, Jane M

    2015-11-15

    Understanding the drivers and implications of anthropogenic disturbance of ecological connectivity is a key concern for the conservation of biodiversity and ecosystem processes. Here, we review human activities that affect the movements and dispersal of aquatic organisms, including damming of rivers, river regulation, habitat loss and alteration, human-assisted dispersal of organisms and climate change. Using a series of case studies, we show that the insight needed to understand the nature and implications of connectivity, and to underpin conservation and management, is best achieved via data synthesis from multiple analytical approaches. We identify four key knowledge requirements for progressing our understanding of the effects of anthropogenic impacts on ecological connectivity: autecology; population structure; movement characteristics; and environmental tolerance/phenotypic plasticity. Structuring empirical research around these four broad data requirements, and using this information to parameterise appropriate models and develop management approaches, will allow for mitigation of the effects of anthropogenic disturbance on ecological connectivity in aquatic ecosystems. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Nursing implications of personalized and precision medicine.

    PubMed

    Vorderstrasse, Allison A; Hammer, Marilyn J; Dungan, Jennifer R

    2014-05-01

    Identify and discuss the nursing implications of personalized and precision oncology care. PubMed, CINAHL. The implications in personalized and precision cancer nursing care include interpretation and clinical use of novel and personalized information including genetic testing; patient advocacy and support throughout testing, anticipation of results and treatment; ongoing chronic monitoring; and support for patient decision-making. Attention must also be given to the family and ethical implications of a personalized approach to care. Nurses face increasing challenges and opportunities in communication, support, and advocacy for patients given the availability of advanced testing, care and treatment in personalized and precision medicine. Nursing education and continuing education, clinical decision support, and health systems changes will be necessary to provide personalized multidisciplinary care to patients, in which nurses play a key role. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Motivation and temporal distance: effect on cognitive and affective manifestations.

    PubMed

    Bjørnebekk, Gunnar; Gjesme, Torgrim

    2009-10-01

    The implications of temporal distance on motivation-related concepts were examined. The results of an experiment, based on 585 Grade 6 students, indicated that both positive (approach) and negative (avoidance) motivation increased as the future goal or event approached in time. This increase in approach and avoidance motivation influenced the performance of the pupils differently. For pupils with success orientation, the performance increased. For pupils with failure orientation, the performance remained about the same.

  4. My Name is not Kevin...It's Michelangelo

    ERIC Educational Resources Information Center

    Elliott, Marion L.

    1977-01-01

    An unique approach toward a deeper understanding of art and artists by elementary school students, author also suggests implications for strengthening the basic skills of reading and writing. (Editor)

  5. Gauging Through the Crowd: A Crowd-Sourcing Approach to Urban Rainfall Measurement and Storm Water Modeling Implications

    NASA Astrophysics Data System (ADS)

    Yang, Pan; Ng, Tze Ling

    2017-11-01

    Accurate rainfall measurement at high spatial and temporal resolutions is critical for the modeling and management of urban storm water. In this study, we conduct computer simulation experiments to test the potential of a crowd-sourcing approach, where smartphones, surveillance cameras, and other devices act as precipitation sensors, as an alternative to the traditional approach of using rain gauges to monitor urban rainfall. The crowd-sourcing approach is promising as it has the potential to provide high-density measurements, albeit with relatively large individual errors. We explore the potential of this approach for urban rainfall monitoring and the subsequent implications for storm water modeling through a series of simulation experiments involving synthetically generated crowd-sourced rainfall data and a storm water model. The results show that even under conservative assumptions, crowd-sourced rainfall data lead to more accurate modeling of storm water flows as compared to rain gauge data. We observe the relative superiority of the crowd-sourcing approach to vary depending on crowd participation rate, measurement accuracy, drainage area, choice of performance statistic, and crowd-sourced observation type. A possible reason for our findings is the differences between the error structures of crowd-sourced and rain gauge rainfall fields resulting from the differences between the errors and densities of the raw measurement data underlying the two field types.

  6. Cognitive abilities of preschool children: implications for nurses working with young children.

    PubMed

    Hauck, M R

    1991-08-01

    To effectively care for well or ill children, nurses must know something about how children think and what they are capable of comprehending. Nurses have traditionally based assumptions about children's cognitive abilities on a surface knowledge of Piaget's theory of cognitive development. Many recent researchers in the field of cognitive development have pointed out limitations in Piaget's theory and offer new ways of conceptualizing the way children think. In this article, I will identify limitations of Piaget's theory as it applies to preschool-aged children. Ideas of researchers using an information processing approach to understanding children's thinking will be described as alternative approaches to the understanding of preschool thought. I prescriptively postulate how research findings concerning cognition have implications for nurses working with young children.

  7. Climate Change, Public Health, and Policy: A California Case Study

    PubMed Central

    Smith, Jason A.

    2018-01-01

    Anthropogenic activity will bring immediate changes and disruptions to the global climate with accompanying health implications. Although policymakers and public health advocates are beginning to acknowledge the health implications of climate change, current policy approaches are lagging behind. We proposed that 4 key policy principles are critical to successful policymaking in this arena: mainstreaming, linking mitigation and adaptation policy, applying population perspectives, and coordination. We explored California’s progress in addressing the public health challenges of climate change in the San Joaquin Valley as an example. We discussed issues of mental health and climate change, and used the San Joaquin Valley of California as an example to explore policy approaches to health issues and climate change. The California experience is instructive for other jurisdictions. PMID:29072936

  8. Women's self-perception and self-care practice: implications for health care delivery.

    PubMed

    Mendias, E P; Clark, M C; Guevara, E B

    2001-01-01

    Mexican American women experience unique health care needs related to integration of Mexican and American cultures. To learn how to better promote self-care practices and service utilization in women of Mexican origin living in Texas, researchers used a qualitative approach to interview a convenience sample of 11 low-income women attending a health clinic. Researchers collected narrative data about the women's perceptions of health, wellness, and self-care. Using the matrix approach described by Miles and Huberman, we organized findings around women's roles, including participants' descriptions of themselves, their health and wellness awareness, self-care practices for health/illness and wellness/nonwellness, barriers to self-care, origin of self-care practices, and perceptions of life control. Implications for health planning and service delivery are presented.

  9. New VLBI2010 scheduling strategies and implications on the terrestrial reference frames.

    PubMed

    Sun, Jing; Böhm, Johannes; Nilsson, Tobias; Krásná, Hana; Böhm, Sigrid; Schuh, Harald

    In connection with the work for the next generation VLBI2010 Global Observing System (VGOS) of the International VLBI Service for Geodesy and Astrometry, a new scheduling package (Vie_Sched) has been developed at the Vienna University of Technology as a part of the Vienna VLBI Software. In addition to the classical station-based approach it is equipped with a new scheduling strategy based on the radio sources to be observed. We introduce different configurations of source-based scheduling options and investigate the implications on present and future VLBI2010 geodetic schedules. By comparison to existing VLBI schedules of the continuous campaign CONT11, we find that the source-based approach with two sources has a performance similar to the station-based approach in terms of number of observations, sky coverage, and geodetic parameters. For an artificial 16 station VLBI2010 network, the source-based approach with four sources provides an improved distribution of source observations on the celestial sphere. Monte Carlo simulations yield slightly better repeatabilities of station coordinates with the source-based approach with two sources or four sources than the classical strategy. The new VLBI scheduling software with its alternative scheduling strategy offers a promising option with respect to applications of the VGOS.

  10. Spatial distribution of diesel transit bus emissions and urban populations: implications of coincidence and scale on exposure.

    PubMed

    Gouge, Brian; Ries, Francis J; Dowlatabadi, Hadi

    2010-09-15

    Macroscale emissions modeling approaches have been widely applied in impact assessments of mobile source emissions. However, these approaches poorly characterize the spatial distribution of emissions and have been shown to underestimate emissions of some pollutants. To quantify the implications of these limitations on exposure assessments, CO, NO(X), and HC emissions from diesel transit buses were estimated at 50 m intervals along a bus rapid transit route using a microscale emissions modeling approach. The impacted population around the route was estimated using census, pedestrian count and transit ridership data. Emissions exhibited significant spatial variability. In intervals near major intersections and bus stops, emissions were 1.6-3.0 times higher than average. The coincidence of these emission hot spots and peaks in pedestrian populations resulted in a 20-40% increase in exposure compared to estimates that assumed homogeneous spatial distributions of emissions and/or populations along the route. An additional 19-30% increase in exposure resulted from the underestimate of CO and NO(X) emissions by macroscale modeling approaches. The results of this study indicate that macroscale modeling approaches underestimate exposure due to poor characterization of the influence of vehicle activity on the spatial distribution of emissions and total emissions.

  11. New VLBI2010 scheduling strategies and implications on the terrestrial reference frames

    NASA Astrophysics Data System (ADS)

    Sun, Jing; Böhm, Johannes; Nilsson, Tobias; Krásná, Hana; Böhm, Sigrid; Schuh, Harald

    2014-05-01

    In connection with the work for the next generation VLBI2010 Global Observing System (VGOS) of the International VLBI Service for Geodesy and Astrometry, a new scheduling package (Vie_Sched) has been developed at the Vienna University of Technology as a part of the Vienna VLBI Software. In addition to the classical station-based approach it is equipped with a new scheduling strategy based on the radio sources to be observed. We introduce different configurations of source-based scheduling options and investigate the implications on present and future VLBI2010 geodetic schedules. By comparison to existing VLBI schedules of the continuous campaign CONT11, we find that the source-based approach with two sources has a performance similar to the station-based approach in terms of number of observations, sky coverage, and geodetic parameters. For an artificial 16 station VLBI2010 network, the source-based approach with four sources provides an improved distribution of source observations on the celestial sphere. Monte Carlo simulations yield slightly better repeatabilities of station coordinates with the source-based approach with two sources or four sources than the classical strategy. The new VLBI scheduling software with its alternative scheduling strategy offers a promising option with respect to applications of the VGOS.

  12. Global Warming: Its Implications for U.S. National Security Policy

    DTIC Science & Technology

    2009-03-19

    The approach to this topic will be to look at the science behind anthropogenic global warming . Is man largely responsible for causing global warming due...paper will then investigate the nexus between global warming and U.S. national security policy. It will address the challenges facing U.S. leaders and...policy makers as they tackle the issue of global warming and its implications for U.S. policy. Finally it will conclude with recommendations for those

  13. A social implications of computing course which teaches computer ethics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pulliam, S.C.

    1994-12-31

    Computers are integral to today`s world, forming our society as well as responding to it, In recognition of this interaction, as well as in response to requirements by the Computer Science Accrediting Board (CSAB), many schools are incorporating computer ethics and values and addressing the social implications of computing within their curriculum. The approach discussed here is through a separate course, rather than relying on the integration of specific topics throughout the curriculum.

  14. Toward a new approach to the study of personality in culture.

    PubMed

    Cheung, Fanny M; van de Vijver, Fons J R; Leong, Frederick T L

    2011-10-01

    We review recent developments in the study of culture and personality measurement. Three approaches are described: an etic approach that focuses on establishing measurement equivalence in imported measures of personality, an emic (indigenous) approach that studies personality in specific cultures, and a combined emic-etic approach to personality. We propose the latter approach as a way of combining the methodological rigor of the etic approach and the cultural sensitivity of the emic approach. The combined approach is illustrated by two examples: the first with origins in Chinese culture and the second in South Africa. The article ends with a discussion of the theoretical and practical implications of the combined emic-etic approach for the study of culture and personality and for psychology as a science.

  15. Consumerism and consumer complexity: implications for university teaching and teaching evaluation.

    PubMed

    Hall, Wendy A

    2013-07-01

    A contemporary issue is the effects of a corporate production metaphor and consumerism on university education. Efforts by universities to attract students and teaching strategies aimed at 'adult learners' tend to treat student consumers as a homogeneous group with similar expectations. In this paper, I argue that consumer groups are not uniform. I use Dagevos' theoretical approach to categorize consumers as calculating, traditional, unique, and responsible. Based on the characteristics of consumers occupying these categories, I describe the implications of the varying consumer expectations for teaching. I also consider the implications for evaluation of teaching and call for research taking consumer types into account when evaluating teaching. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Additive Manufacturing Modeling and Simulation A Literature Review for Electron Beam Free Form Fabrication

    NASA Technical Reports Server (NTRS)

    Seufzer, William J.

    2014-01-01

    Additive manufacturing is coming into industrial use and has several desirable attributes. Control of the deposition remains a complex challenge, and so this literature review was initiated to capture current modeling efforts in the field of additive manufacturing. This paper summarizes about 10 years of modeling and simulation related to both welding and additive manufacturing. The goals were to learn who is doing what in modeling and simulation, to summarize various approaches taken to create models, and to identify research gaps. Later sections in the report summarize implications for closed-loop-control of the process, implications for local research efforts, and implications for local modeling efforts.

  17. Improving care transitions through meaningful use stage 2: continuity of care document.

    PubMed

    Murphy, Lyn Stankiewicz; Wilson, Marisa L; Newhouse, Robin P

    2013-02-01

    In this department, Drs Murphy, Wilson, and Newhouse highlight hot topics in nursing outcomes, research, and evidence-based practice relevant to the nurse administrator. The goal is to discuss the practical implications for nurse leaders in diverse healthcare settings. Content includes evidence-based projects and decision making, locating measurement tools for quality improvement and safety projects, using outcome measures to evaluate quality, practice implications of administrative research, and exemplars of projects that demon strate innovative approaches to organizational problems. In this article, the authors describe the elements of continuity of care documentation, how sharing information can improve the quality and safety of care transitions and the implications for nurse executives.

  18. Implications of the Marketization of Higher Education for Social Emotional Development in Schools: A Personal View

    ERIC Educational Resources Information Center

    Cooper, Paul

    2014-01-01

    This essay discusses the institutional dysfunction that has resulted from the misguided belief that a market forces approach leads to the improvement of teaching quality and learning outcomes. Because the market forces approach is based on a simplistic input-output model that pays scant attention to teaching and learning processes, it is an…

  19. Exploring the Effects of Gender and Learning Styles on Computer Programming Performance: Implications for Programming Pedagogy

    ERIC Educational Resources Information Center

    Lau, Wilfred W. F.; Yuen, Allan H. K.

    2009-01-01

    Computer programming has been taught in secondary schools for more than two decades. However, little is known about how students learn to program. From the curriculum implementation perspectives, learning style helps address the issue of learner differences, resulting in a shift from a teacher-centred approach to a learner-focused approach. This…

  20. Predicting climate-induced range shifts: model differences and model reliability.

    Treesearch

    Joshua J. Lawler; Denis White; Ronald P. Neilson; Andrew R. Blaustein

    2006-01-01

    Predicted changes in the global climate are likely to cause large shifts in the geographic ranges of many plant and animal species. To date, predictions of future range shifts have relied on a variety of modeling approaches with different levels of model accuracy. Using a common data set, we investigated the potential implications of alternative modeling approaches for...

  1. An Empirical Appraisal of Canadian Doctoral Dissertations Using Grounded Theory: Implications for Social Work Research and Teaching

    ERIC Educational Resources Information Center

    Braganza, Morgan; Akesson, Bree; Rothwell, David

    2017-01-01

    Grounded theory is a popular methodological approach in social work research, especially by doctoral students conducting qualitative research. The approach, however, is not always used consistently or as originally designed, compromising the quality of the research. The aim of the current study is to assess the quality of recent Canadian social…

  2. Factorial Validity of a Questionnaire to Evaluate University Students' Initial Perception of Learning Evaluation

    ERIC Educational Resources Information Center

    Doménech-Betoret, Fernando; Fortea-Bagán, Miguel Angel

    2015-01-01

    Introduction: Education research has clearly verified that a student's perception of the system to evaluate the subject matter will play a fundamental role in his/her implication (deep approach vs. surface approach) in the teaching/learning process of the subject matter. The present work aims to examine the factorial validity and reliability of a…

  3. (Re)Reading National Identities in School Historiographies: Pedagogical Implications from the Case of Cyprus

    ERIC Educational Resources Information Center

    Klerides, Eleftherios

    2016-01-01

    The article, using Cyprus as a case study, seeks to reframe disputes over the nature of national identities constituted in school historiographies and it does so by introducing a novel approach to the study of the making of identity in school history. This approach, grounded on post-foundational thinking and an inter-discursive mode of textual…

  4. Examining the Missing Completely at Random Mechanism in Incomplete Data Sets: A Multiple Testing Approach

    ERIC Educational Resources Information Center

    Raykov, Tenko; Lichtenberg, Peter A.; Paulson, Daniel

    2012-01-01

    A multiple testing procedure for examining implications of the missing completely at random (MCAR) mechanism in incomplete data sets is discussed. The approach uses the false discovery rate concept and is concerned with testing group differences on a set of variables. The method can be used for ascertaining violations of MCAR and disproving this…

  5. Sport, Moral Development, and the Role of the Teacher: Implications for Research and Moral Education.

    ERIC Educational Resources Information Center

    Arnold, Peter J.

    2001-01-01

    Examines the inadequacies of some purely justice or moral reasoning approaches to moral development in sport, especially when viewed from the perspective of virtue theory and Aristotelian concepts of phronesis and habituation, arguing that the latter approach provides more complete criteria for formulating a new model of the nature of the moral.…

  6. Linking nursing theory and practice: a critical-feminist approach.

    PubMed

    Georges, Jane M

    2005-01-01

    Situated in a critical-feminist perspective, this article describes a pedagogical approach to linking nursing theory and practice. The inclusion of the critical humanities is emphasized in creating an environment in which this linkage can be reified for learners. Implications for the future of nursing theory and its links to practice in the context of current political realities in academia are considered.

  7. A Conceptual Discussion of Lesson Study from a Micro-Political Perspective: Implications for Teacher Development and Pupil Learning

    ERIC Educational Resources Information Center

    Saito, Eisuke; Atencio, Matthew

    2013-01-01

    Lesson study has been implemented as a viable approach to support teachers' professional development. Yet, this approach has not been thoroughly examined in relation to key micro-political power relations that are arguably endemic to the use of this collaborative learning model. Accordingly, this paper discusses post-structural concepts that might…

  8. Are High Achievers Successful in Collaborative Learning? An Explorative Study of College Students' Learning Approaches in Team Project-Based Learning

    ERIC Educational Resources Information Center

    Lee, Hye-Jung; Kim, Hyekyung; Byun, Hyunjung

    2017-01-01

    This study analyses how high-achieving students approach team project-based learning (TPBL) and aims to identify the implications and challenges of TPBL practice in higher education. After interviewing 32 high-achieving students and surveying 1022 additional students at a South Korean university, we found that four factors were particularly…

  9. Sampling Practices and Social Spaces: Exploring a Hip-Hop Approach to Higher Education

    ERIC Educational Resources Information Center

    Petchauer, Emery

    2010-01-01

    Much more than a musical genre, hip-hop culture exists as an animating force in the lives of many young adults. This article looks beyond the moral concerns often associated with rap music to explore how hip-hop as a larger set of expressions and practices implicates the educational experiences, activities, and approaches for students. The article…

  10. Stochastic modeling of consumer preferences for health care institutions.

    PubMed

    Malhotra, N K

    1983-01-01

    This paper proposes a stochastic procedure for modeling consumer preferences via LOGIT analysis. First, a simple, non-technical exposition of the use of a stochastic approach in health care marketing is presented. Second, a study illustrating the application of the LOGIT model in assessing consumer preferences for hospitals is given. The paper concludes with several implications of the proposed approach.

  11. Students' Conception of Learning Environment and Their Approach to Learning and Its Implication on Quality Education

    ERIC Educational Resources Information Center

    Belaineh, Matheas Shemelis

    2017-01-01

    Quality of education in higher institutions can be affected by different factors. It partly rests on the learning environment created by teachers and the learning approach students are employing during their learning. The main purpose of this study is to examine the learning environment at Mizan Tepi University from students' perspective and their…

  12. The Unequal Burden of Weight Gain: An Intersectional Approach to Understanding Social Disparities in BMI Trajectories from 1986 to 2001/2002

    ERIC Educational Resources Information Center

    Ailshire, Jennifer A.; House, James S.

    2011-01-01

    The implications of recent weight gain trends for widening social disparities in body weight in the United States are unclear. Using an intersectional approach to studying inequality, and the longitudinal and nationally representative American's Changing Lives study (1986-2001/2002), we examine social disparities in body mass index trajectories…

  13. The Impact of Changing Policies about Technology on the Professional Development Needs of Early Years Educators in England

    ERIC Educational Resources Information Center

    Ingleby, Ewan

    2015-01-01

    This paper considers the implications of UK policy approaches to ICT (Information Communication Technology) in education by exploring the views of early years (0-8 years) educators about their ICT CPD (continuing professional development) needs. UK policy approaches to ICT may be visualised as a "house that Jack built." The policies are…

  14. A Comparative Study of Singapore's School Excellence Model with Hong Kong's School-Based Management

    ERIC Educational Resources Information Center

    Ng, Pak Tee; Chan, David

    2008-01-01

    Purpose: This paper aims to examine and compare the school excellence model (SEM) approach adopted by Singapore and the school-based management (SBM) approach adopted by Hong Kong. It discusses the implications of such a strategy and the challenges that both Singapore and Hong Kong schools face in navigating a new paradigm of managerialism while…

  15. What does the new breed of decision-making methodologies mean for choices and norms in hydrological science?

    NASA Astrophysics Data System (ADS)

    Wikman-Svahn, Per

    2013-04-01

    Hydrological sciences are increasingly utilized in decision-making contexts that need to manage deep uncertainty, changing conditions and very long-lead times and lifetimes. Traditional optimizing approaches become problematic in such situations. For example, optimizing approaches may underestimate the importance of low probability outcomes, or very uncertain outcomes. Alternative decision-making strategies are therefore increasingly used in hydrological applications, including "bottom-up/top-down", "context-first", "decision-scaling", "assess risk of policy", "robust", "resilient" or "flexible" approaches. These kinds of strategies are typically designed to handle very uncertain and diverse outcomes, and often start from the particular decision-making context, in contrast to more traditional "predict-then-act" or "science first" approaches. Contemporary research in philosophy of science stress the influence of value judgments and norms in scientific assessments. In particular, this literature points out that implicit anticipated applications often influence choices made in scientific assessments. Furthermore, this literature also emphasize that choices made at within scientific assessments have consequences for decision-making later on. One reason is that it is often difficult for decision-makers to see what choices are made and the implications of these choices. Another reason is that information that could be of use for decision-makers are lost at an early stage. For example, the choice to focus on central estimates and not providing assessments on more unlikely outcomes is a choice that has consequences for what outcomes are taken into account in the decision-making process. This paper develops this argument and then analyzes the implications of these new developments for hydrological science. One implication of the increasing use of the new breed of planning strategies is that a broader range of uncertainty in scientific assessments becomes desirable in order to fully benefit from the power of the new decision-making strategies. Another implication is that bayesian probability assessments become more important. Finally, advantages and risks involved in changing scientific assessments in order to anticipate the new decision-making strategies are discussed.

  16. Limited Agreement of Independent RNAi Screens for Virus-Required Host Genes Owes More to False-Negative than False-Positive Factors

    PubMed Central

    Wang, Zhishi; Craven, Mark; Newton, Michael A.; Ahlquist, Paul

    2013-01-01

    Systematic, genome-wide RNA interference (RNAi) analysis is a powerful approach to identify gene functions that support or modulate selected biological processes. An emerging challenge shared with some other genome-wide approaches is that independent RNAi studies often show limited agreement in their lists of implicated genes. To better understand this, we analyzed four genome-wide RNAi studies that identified host genes involved in influenza virus replication. These studies collectively identified and validated the roles of 614 cell genes, but pair-wise overlap among the four gene lists was only 3% to 15% (average 6.7%). However, a number of functional categories were overrepresented in multiple studies. The pair-wise overlap of these enriched-category lists was high, ∼19%, implying more agreement among studies than apparent at the gene level. Probing this further, we found that the gene lists implicated by independent studies were highly connected in interacting networks by independent functional measures such as protein-protein interactions, at rates significantly higher than predicted by chance. We also developed a general, model-based approach to gauge the effects of false-positive and false-negative factors and to estimate, from a limited number of studies, the total number of genes involved in a process. For influenza virus replication, this novel statistical approach estimates the total number of cell genes involved to be ∼2,800. This and multiple other aspects of our experimental and computational results imply that, when following good quality control practices, the low overlap between studies is primarily due to false negatives rather than false-positive gene identifications. These results and methods have implications for and applications to multiple forms of genome-wide analysis. PMID:24068911

  17. An evidence-based approach to the creation of normative data: base rates of impaired scores within a brief neuropsychological battery argue for age corrections, but against corrections for medical conditions.

    PubMed

    O'Connell, Megan E; Tuokko, Holly; Voll, Stacey; Simard, Martine; Griffith, Lauren E; Taler, Vanessa; Wolfson, Christina; Kirkland, Susan; Raina, Parminder

    We detail a new approach to the creation of normative data for neuropsychological tests. The traditional approach to normative data creation is to make demographic adjustments based on observations of correlations between single neuropsychological tests and selected demographic variables. We argue, however, that this does not describe the implications for clinical practice, such as increased likelihood of misclassification of cognitive impairment, nor does it elucidate the impact on decision-making with a neuropsychological battery. We propose base rate analyses; specifically, differential base rates of impaired scores between theoretical and actual base rates as the basis for decisions to create demographic adjustments within normative data. Differential base rates empirically describe the potential clinical implications of failing to create an appropriate normative group. We demonstrate this approach with data from a short telephone-administered neuropsychological battery given to a large, neurologically healthy sample aged 45-85 years old. We explored whether adjustments for age and medical conditions were warranted based on differential base rates of spuriously impaired scores. Theoretical base rates underestimated the frequency of impaired scores in older adults and overestimated the frequency of impaired scores in younger adults, providing an evidence base for the creation of age-corrected normative data. In contrast, the number of medical conditions (numerous cardiovascular, hormonal, and metabolic conditions) was not related to differential base rates of impaired scores. Despite a small correlation between number of medical conditions and each neuropsychological variable, normative adjustments for number of medical conditions does not appear warranted. Implications for creation of normative data are discussed.

  18. Considerations for using data envelopment analysis for the assessment of radiotherapy treatment plan quality.

    PubMed

    Simpson, John; Raith, Andrea; Rouse, Paul; Ehrgott, Matthias

    2017-10-09

    Purpose The operations research method of data envelopment analysis (DEA) shows promise for assessing radiotherapy treatment plan quality. The purpose of this paper is to consider the technical requirements for using DEA for plan assessment. Design/methodology/approach In total, 41 prostate treatment plans were retrospectively analysed using the DEA method. The authors investigate the impact of DEA weight restrictions with reference to the ability to differentiate plan performance at a level of clinical significance. Patient geometry influences plan quality and the authors compare differing approaches for managing patient geometry within the DEA method. Findings The input-oriented DEA method is the method of choice when performing plan analysis using the key undesirable plan metrics as the DEA inputs. When considering multiple inputs, it is necessary to constrain the DEA input weights in order to identify potential plan improvements at a level of clinical significance. All tested approaches for the consideration of patient geometry yielded consistent results. Research limitations/implications This work is based on prostate plans and individual recommendations would therefore need to be validated for other treatment sites. Notwithstanding, the method that requires both optimised DEA weights according to clinical significance and appropriate accounting for patient geometric factors is universally applicable. Practical implications DEA can potentially be used during treatment plan development to guide the planning process or alternatively used retrospectively for treatment plan quality audit. Social implications DEA is independent of the planning system platform and therefore has the potential to be used for multi-institutional quality audit. Originality/value To the authors' knowledge, this is the first published examination of the optimal approach in the use of DEA for radiotherapy treatment plan assessment.

  19. Statistical power for nonequivalent pretest-posttest designs. The impact of change-score versus ANCOVA models.

    PubMed

    Oakes, J M; Feldman, H A

    2001-02-01

    Nonequivalent controlled pretest-posttest designs are central to evaluation science, yet no practical and unified approach for estimating power in the two most widely used analytic approaches to these designs exists. This article fills the gap by presenting and comparing useful, unified power formulas for ANCOVA and change-score analyses, indicating the implications of each on sample-size requirements. The authors close with practical recommendations for evaluators. Mathematical details and a simple spreadsheet approach are included in appendices.

  20. PEOPLE IN PHYSICS: David Bohm and the implicate order: a new paradigm for physics teachers

    NASA Astrophysics Data System (ADS)

    Bettany, Laurence

    1998-11-01

    David Bohm (1917-93) was a highly original and individual physicist. His novel ideas and profound intuition extended not only to the physical world but also to the nature of consciousness and society. Bohm regarded science as having become essentially fragmented in its approach to understanding physical reality and sought a more holistic physics based on order, transformation and flowing movement. His notion of an implicate order provides an unusual and exciting challenge for both teachers and students alike.

  1. Would Virchow be a systems biologist? A discourse on the philosophy of science with implications for pathological research.

    PubMed

    Stenzinger, Albrecht; Klauschen, Frederick; Wittschieber, Daniel; Weichert, Wilko; Denkert, Carsten; Dietel, Manfred; Roller, Claudio

    2010-06-01

    Research in pathology spans from merely descriptive work to functional studies, "-omics" approaches and, more recently, systems biology. The work presented here aims at placing pathological research into an epistemological context. Aided by Rudolf Virchow, we give an overview on the philosophy of science including the Wiener Kreis, Popper, Kuhn, Fleck and Rheinberger and demonstrate their implications for routine diagnostics and science in pathology. A focus is on the fields of "-omics" and systems pathology.

  2. Management, Ethics and the Military Chaplin.

    DTIC Science & Technology

    for the rationale that military chaplains should integrate these principles in their work. A practical approach toward the principles of management is suggested and the moral implications of their application is studied. (Author)

  3. Rogerian Psychology and "Non-Directive" Counselling in Schools.

    ERIC Educational Resources Information Center

    Quicke, J. C.

    1978-01-01

    The article discusses the prevalence of the nondirective approach in the school counseling movement and analyzes its psychological rationale and practical implications, centering on the psychological concepts of Carl R. Rogers. (MF)

  4. A SETI Course at University of Western Sydney Macarthur.

    ERIC Educational Resources Information Center

    Bhathal, Ragbir

    1999-01-01

    Describes a course based on the scientific approach to the search for extraterrestrial intelligence. Explores the biological and technological aspects of the search and the social implications of possible contact. (Author/CCM)

  5. Risk Management of New Microelectronics for NASA: Radiation Knowledge-base

    NASA Technical Reports Server (NTRS)

    LaBel, Kenneth A.

    2004-01-01

    Contents include the following: NASA Missions - implications to reliability and radiation constraints. Approach to Insertion of New Technologies Technology Knowledge-base development. Technology model/tool development and validation. Summary comments.

  6. Toward an integrative understanding of narrative and emotion processes in Emotion-focused therapy of depression: implications for theory, research and practice.

    PubMed

    Angus, Lynne

    2012-01-01

    This paper addresses the fundamental contributions of client narrative disclosure in psychotherapy and its importance for the elaboration of new emotional meanings and self understanding in the context of Emotion-focused therapy (EFT) of depression. An overview of the multi-methodological steps undertaken to empirically investigate the contributions of client story telling, emotional differentiation and meaning-making processes (Narrative Processes Coding System; Angus et al., 1999) in EFT treatments of depression is provided, followed by a summary of key research findings that informed the development of a narrative-informed approach to Emotion-focused therapy of depression (Angus & Greenberg, 2011). Finally, the clinical practice and training implications of adopting a research-informed approach to working with narrative and emotion processes in EFT are described, and future research directions discussed.

  7. Epigenetics: relevance and implications for public health.

    PubMed

    Rozek, Laura S; Dolinoy, Dana C; Sartor, Maureen A; Omenn, Gilbert S

    2014-01-01

    Improved understanding of the multilayer regulation of the human genome has led to a greater appreciation of environmental, nutritional, and epigenetic risk factors for human disease. Chromatin remodeling, histone tail modifications, and DNA methylation are dynamic epigenetic changes responsive to external stimuli. Careful interpretation can provide insights for actionable public health through collaboration between population and basic scientists and through integration of multiple data sources. We review key findings in environmental epigenetics both in human population studies and in animal models, and discuss the implications of these results for risk assessment and public health protection. To ultimately succeed in identifying epigenetic mechanisms leading to complex phenotypes and disease, researchers must integrate the various animal models, human clinical approaches, and human population approaches while paying attention to life-stage sensitivity, to generate effective prescriptions for human health evaluation and disease prevention.

  8. The fuel market effects of biofuel policies and implications for regulations based on lifecycle emissions

    NASA Astrophysics Data System (ADS)

    Rajagopal, Deepak

    2013-06-01

    The absence of a globally-consistent and binding commitment to reducing greenhouse emissions provides a rationale for partial policies, such as renewable energy mandates, product emission standards, etc to target lifecycle emissions of the regulated products or services. While appealing in principle, regulation of lifecycle emissions presents several practical challenges. Using biofuels as an illustrative example, we highlight some outstanding issues in the design and implementation of life cycle-based policies and discuss potential remedies. We review the literature on emissions due to price effects in fuel markets, which are akin to emissions due to indirect land use change, but are, unlike the latter, ignored under all current life cycle emissions-based regulations. We distinguish the current approaches to regulating indirect emissions into hard and soft approaches and discuss their implications.

  9. Lorentz Invariance Violation effects on UHECR propagation: A geometrized approach

    NASA Astrophysics Data System (ADS)

    Torri, Marco Danilo Claudio; Bertini, Stefano; Giammarchi, Marco; Miramonti, Lino

    2018-06-01

    We explore the possibility to geometrize the interaction of massive fermions with the quantum structure of space-time, trying to create a theoretical background, in order to explain what some recent experimental results seem to implicate on the propagation of Ultra High Energy Cosmic Rays (UHECR). We will investigate part of the phenomenological implications of this approach on the predicted effect of the UHECR suppression, in fact recent evidences seem to involve the modification of the GZK cut-off phenomenon. The search for an effective theory, which can explain this physical effect, is based on Lorentz Invariance Violation (LIV), which is introduced via Modified Dispersion Relations (MDRs). Furthermore we illustrate that this perspective implies a more general geometry of space-time than the usual Riemannian one, indicating, for example, the opportunity to resort to Finsler theory.

  10. Mars Global Surveyor Data Analysis Program. Origins of Small Volcanic Cones: Eruption Mechanisms and Implications for Water on Mars

    NASA Technical Reports Server (NTRS)

    Fagents, Sarah A.; Greeley, Ronald; Thordarson, Thorvaldur

    2002-01-01

    The goal of the proposed work was to determine the origins of small volcanic cones observed in Mars Global Surveyor (MGS) data, and their implications for regolith ice stores and magma volatile contents. For this 1-year study, our approach involved a combination of: Quantitative morphologic analysis and interpretation of Mars Orbiter Camera (MOC) and Mars Orbiter Laser Altimeter (MOLA) data; Numerical modeling of eruption processes responsible for producing the observed features; Fieldwork on terrestrial analogs in Iceland. Following this approach, this study succeeded in furthering our understanding of (i) the spatial and temporal distribution of near-surface water ice, as defined by the distribution and sizes of rootless volcanic cones ("pseudocraters"), and (ii) the properties, eruption conditions, and volatile contents of magmas producing primary vent cones.

  11. Visual cueing aids for rotorcraft landings

    NASA Technical Reports Server (NTRS)

    Johnson, Walter W.; Andre, Anthony D.

    1993-01-01

    The present study used a rotorcraft simulator to examine descents-to-hover at landing pads with one of three approach lighting configurations. The impact of simulator platform motion upon descents to hover was also examined. The results showed that the configuration with the most useful optical information led to the slowest final approach speeds, and that pilots found this configuration, together with the presence of simulator platform motion, most desirable. The results also showed that platform motion led to higher rates of approach to the landing pad in some cases. Implications of the results for the design of vertiport approach paths are discussed.

  12. An integrative approach to apprehend desistance.

    PubMed

    F-Dufour, Isabelle; Brassard, Renée; Martel, Joane

    2015-05-01

    The process underlying desistance is still a strong subject of debate. This article seeks to introduce several core concepts of Archer's morphogenic approach to study how people desist from crime. At first, it discusses the primary existing theories of desistance. Then, this article demonstrates the usefulness of this approach by presenting empirical evidence drawn from semistructured interviews collected with 29 men who desisted from crime in an eastern province of Canada. The study demonstrates how this alternative approach allows for the consolidation of existing knowledge on desistance. Then implication of these findings for both theory and practice are discussed. © The Author(s) 2013.

  13. Psychosocial stress and cardiovascular disease. Part 3: Clinical and policy implications of research on the transcendental meditation program.

    PubMed

    Walton, Kenneth G; Schneider, Robert H; Salerno, John W; Nidich, Sanford I

    2005-01-01

    Cardiovascular disease (CVD) remains the leading cause of death in the United States today and a major contributor to total health care costs. Psychosocial stress has been implicated in CVD, and psychosocial approaches to primary and secondary prevention are gaining research support. This third article in the series on psychosocial stress and CVD continues the evaluation of one such approach, the Maharishi Transcendental Meditation program, a psychophysiological approach from the Vedic tradition that is systematically taught by qualified teachers throughout the world. Evidence suggests not only that this program can provide benefits in prevention but also that it may reduce CVD-related and other health care expenses. On the basis of data from the studies available to date, the Transcendental Meditation program may be responsible for reductions of 80% or greater in medical insurance claims and payments to physicians. This article evaluates the implications of research on the Transcendental Meditation program for health care policy and for large-scale clinical implementation of the program. The Transcendental Meditation program can be used by individuals of any ethnic or cultural background, and compliance with the practice regimen is generally high. The main steps necessary for wider adoption appear to be: (1) educating health care providers and patients about the nature and expected benefits of the program, and (2) adjustments in public policies at the state and national levels to allow this program to be included in private and public health insurance plans.

  14. Implementing a new governance model.

    PubMed

    Stanley-Clarke, Nicky; Sanders, Jackie; Munford, Robyn

    2016-05-16

    Purpose - The purpose of this paper is to discuss the lessons learnt from the process of implementing a new model of governance within Living Well, a New Zealand statutory mental health agency. Design/methodology/approach - It presents the findings from an organisational case study that involved qualitative interviews, meeting observations and document analysis. Archetype theory provided the analytical framework for the research enabling an analysis of both the formal structures and informal value systems that influenced the implementation of the governance model. Findings - The research found that the move to a new governance model did not proceed as planned. It highlighted the importance of staff commitment, the complexity of adopting a new philosophical approach and the undue influence of key personalities as key determining factors in the implementation process. The findings suggest that planners and managers within statutory mental health agencies need to consider the implications of any proposed governance change on existing roles and relationships, thinking strategically about how to secure professional commitment to change. Practical implications - There are ongoing pressures within statutory mental health agencies to improve the efficiency and effectiveness of organisational structures and systems. This paper has implications for how planners and managers think about the process of implementing new governance models within the statutory mental health environment in order to increase the likelihood of sustaining and embedding new approaches to service delivery. Originality/value - The paper presents insights into the process of implementing new governance models within a statutory mental health agency in New Zealand that has relevance for other jurisdictions.

  15. Ultrasound and Microbubble Guided Drug Delivery: Mechanistic Understanding and Clinical Implications

    PubMed Central

    Wang, Tzu-Yin; Wilson, Katheryne E.; Machtaler, Steven; Willmann, Jürgen K.

    2014-01-01

    Ultrasound mediated drug delivery using microbubbles is a safe and noninvasive approach for spatially localized drug administration. This approach can create temporary and reversible openings on cellular membranes and vessel walls (a process called “sonoporation”), allowing for enhanced transport of therapeutic agents across these natural barriers. It is generally believed that the sonoporation process is highly associated with the energetic cavitation activities (volumetric expansion, contraction, fragmentation, and collapse) of the microbubble. However, a thorough understanding of the process was unavailable until recently. Important progress on the mechanistic understanding of sonoporation and the corresponding physiological responses in vitro and in vivo has been made. Specifically, recent research shed light on the cavitation process of microbubbles and fluid motion during insonation of ultrasound, on the spatio-temporal interactions between microbubbles and cells or vessel walls, as well as on the temporal course of the subsequent biological effects. These findings have significant clinical implications on the development of optimal treatment strategies for effective drug delivery. In this article, current progress in the mechanistic understanding of ultrasound and microbubble mediated drug delivery and its implications for clinical translation is discussed. PMID:24372231

  16. Rating and Ranking the Role of Bibliometrics and Webometrics in Nursing and Midwifery

    PubMed Central

    Davidson, Patricia M.; Newton, Phillip J.; Ferguson, Caleb

    2014-01-01

    Background. Bibliometrics are an essential aspect of measuring academic and organizational performance. Aim. This review seeks to describe methods for measuring bibliometrics, identify the strengths and limitations of methodologies, outline strategies for interpretation, summarise evaluation of nursing and midwifery performance, identify implications for metric of evaluation, and specify the implications for nursing and midwifery and implications of social networking for bibliometrics and measures of individual performance. Method. A review of electronic databases CINAHL, Medline, and Scopus was undertaken using search terms such as bibliometrics, nursing, and midwifery. The reference lists of retrieved articles and Internet sources and social media platforms were also examined. Results. A number of well-established, formal ways of assessment have been identified, including h- and c-indices. Changes in publication practices and the use of the Internet have challenged traditional metrics of influence. Moreover, measuring impact beyond citation metrics is an increasing focus, with social media representing newer ways of establishing performance and impact. Conclusions. Even though a number of measures exist, no single bibliometric measure is perfect. Therefore, multiple approaches to evaluation are recommended. However, bibliometric approaches should not be the only measures upon which academic and scholarly performance are evaluated. PMID:24550691

  17. Wave particle duality, the observer and retrocausality

    NASA Astrophysics Data System (ADS)

    Narasimhan, Ashok; Kafatos, Menas C.

    2017-05-01

    We approach wave particle duality, the role of the observer and implications on Retrocausality, by starting with the results of a well verified quantum experiment. We analyze how some current theoretical approaches interpret these results. We then provide an alternative theoretical framework that is consistent with the observations and in many ways simpler than usual attempts to account for retrocausality, involving a non-local conscious Observer.

  18. Education and Criminal Justice: The Educational Approach to Prison Administration. The United Nations Standard Minimum Rules for the Treatment of Prisoners.

    ERIC Educational Resources Information Center

    Morin, Lucien; Cosman, J. W.

    The United Nations Standard Minimum Rules for the Treatment of Prisoners do not express the basic principle that would support a serious educational approach to prison administration. The crucial missing rationale is the concept of the inherent dignity of the individual human prisoner. This concept has certain basic educational implications,…

  19. Do They Feel the Same Way about Math? Testing Measurement Invariance of the PISA "Students' Approaches to Learning" Instrument across Immigrant Groups within Germany

    ERIC Educational Resources Information Center

    Segeritz, Micha; Pant, Hans Anand

    2013-01-01

    This article summarizes the key finding of a study that (a) tests the measurement invariance (MI) of the popular Students' Approaches to Learning instrument (Programme for International Student Assessment [PISA]) across ethnic/cultural groups within a country and (b) discusses implications for research focusing on the role of affective measures in…

  20. Mapping an Experiment-Based Assessment of Collaborative Behavior onto Collaborative Problem Solving in PISA 2015: A Cluster Analysis Approach for Collaborator Profiles

    ERIC Educational Resources Information Center

    Herborn, Katharina; Mustafic, Maida; Greiff, Samuel

    2017-01-01

    Collaborative problem solving (CPS) assessment is a new academic research field with a number of educational implications. In 2015, the Programme for International Student Assessment (PISA) assessed CPS with a computer-simulated human-agent (H-A) approach that claimed to measure 12 individual CPS skills for the first time. After reviewing the…

  1. A Derived Relations Analysis of Approach-Avoidance Conflict: Implications for the Behavioral Analysis of Human Anxiety

    ERIC Educational Resources Information Center

    Gannon, Steven; Roche, Bryan; Kanter, Jonathan W.; Forsyth, John P.; Linehan, Conor

    2011-01-01

    The current article reports two experiments designed to examine the effects of creating competing approach and avoidance response functions for 2 stimuli that participate in the same derived stimulus relation. Experiment 1 involved establishing each of 2 distinct members (i.e., B1 and D1) of the same 1-node equivalence relation (A-B-C-D) as a…

  2. The effects of a new therapeutic triclosan/copolymer/sodium-fluoride dentifrice on oral bacteria, including odorigenic species.

    PubMed

    Furgang, David; Sreenivasan, Prem K; Zhang, Yun Po; Fine, Daniel H; Cummins, Diane

    2003-09-01

    This investigation examined the in vitro and ex vivo antimicrobial effects of a new dentifrice, Colgate Total Advanced Fresh, formulated with triclosan/copolymer/sodium fluoride, on oral bacteria, including those odorigenic bacteria implicated in bad breath. The effects of Colgate Total Advanced Fresh were compared to commercially available fluoride dentifrices that served as controls. Three experimental approaches were undertaken for these studies. In the first approach, the dentifrice formulations were tested in vitro against 13 species of oral bacteria implicated in bad breath. The second approach examined the antimicrobial activity derived from dentifrice that was adsorbed to and released from hydroxyapatite disks. In this approach, dentifrice-treated hydroxyapatite disks were immersed in a suspension of bacteria, and reduction in bacterial viability from the release of bioactive agents from hydroxyapatite was determined. The third approach examined the effect of treating bacteria immediately after their removal from the oral cavity of 11 adult human volunteers. This ex vivo study examined the viability of cultivable oral bacteria after dentifrice treatment for 2 minutes. Antimicrobial effects were determined by plating Colgate Total Advanced Fresh and control-dentifrice-treated samples on enriched media (for all cultivable oral bacteria) and indicator media (for hydrogen-sulfide-producing organisms), respectively. Results indicated that the antimicrobial effects of Colgate Total Advanced Fresh were significantly greater than either of the other dentifrices for all 13 oral odorigenic bacterial strains tested in vitro (P < or = 0.05). In the second approach, Colgate Total Advanced Fresh-treated hydroxyapatite disks were significantly more active in reducing bacterial growth than the other dentifrices tested (P < or = 0.05). Finally, ex vivo treatment of oral bacteria with Colgate Total Advanced Fresh demonstrated a 90.9% reduction of all oral cultivable bacteria and a 91.5% reduction of oral bacteria producing hydrogen sulfide compared with the control dentifrice. In conclusion, these results, taken together with the significant reductions in clinical malodor scores by Colgate Total Advanced Fresh demonstrated in organoleptic studies, strongly suggest that this dentifrice kills the bacteria that are implicated in the cause of bad breath.

  3. Approaches to a cortical vision prosthesis: implications of electrode size and placement

    NASA Astrophysics Data System (ADS)

    Christie, Breanne P.; Ashmont, Kari R.; House, Paul A.; Greger, Bradley

    2016-04-01

    Objective. In order to move forward with the development of a cortical vision prosthesis, the critical issues in the field must be identified. Approach. To begin this process, we performed a brief review of several different cortical and retinal stimulation techniques that can be used to restore vision. Main results. Intracortical microelectrodes and epicortical macroelectrodes have been evaluated as the basis of a vision prosthesis. We concluded that an important knowledge gap necessitates an experimental in vivo performance evaluation of microelectrodes placed on the surface of the visual cortex. A comparison of the level of vision restored by intracortical versus epicortical microstimulation is necessary. Because foveal representation in the primary visual cortex involves more cortical columns per degree of visual field than does peripheral vision, restoration of foveal vision may require a large number of closely spaced microelectrodes. Based on previous studies of epicortical macrostimulation, it is possible that stimulation via surface microelectrodes could produce a lower spatial resolution, making them better suited for restoring peripheral vision. Significance. The validation of epicortical microstimulation in addition to the comparison of epicortical and intracortical approaches for vision restoration will fill an important knowledge gap and may have important implications for surgical strategies and device longevity. It is possible that the best approach to vision restoration will utilize both epicortical and intracortical microstimulation approaches, applying them appropriately to different visual representations in the primary visual cortex.

  4. Dealing with the long-term social implications of research.

    PubMed

    Fleischman, Alan; Levine, Carol; Eckenwiler, Lisa; Grady, Christine; Hammerschmidt, Dale E; Sugarman, Jeremy

    2011-05-01

    Biomedical and behavioral research may affect strongly held social values and thereby create significant controversy over whether such research should be permitted in the first place. Institutional review boards (IRBs) responsible for protecting the rights and welfare of participants in research are sometimes faced with review of protocols that have significant implications for social policy and the potential for negative social consequences. Although IRB members often raise concerns about potential long-term social implications in protocol review, federal regulations strongly discourage IRBs from considering them in their decisions. Yet IRBs often do consider the social implications of research protocols and sometimes create significant delays in initiating or even prevent such research. The social implications of research are important topics for public scrutiny and professional discussion. This article examines the reasons that the federal regulations preclude IRBs from assessing the social risks of research, and examines alternative approaches that have been used with varying success by national advisory groups to provide such guidance. The article concludes with recommendations for characteristics of a national advisory group that could successfully fulfill this need, including sustainability, independence, diverse and relevant expertise, and public transparency.

  5. Mapping patterns of change in emotion-focused psychotherapy: Implications for theory, research, practice, and training.

    PubMed

    Watson, Jeanne C

    2018-05-01

    An important objective in humanistic-experiential psychotherapies and particularly emotion-focused psychotherapy (EFT) is to map patterns of change. Effective mapping of the processes and pathways of change requires that in-session processes be linked to in-session resolutions, immediate post-session changes, intermediate outcome, final therapy outcome, and longer-term change. This is a challenging and long-term endeavour. Fine-grained descriptions of in-session processes that lead to resolution of specific interpersonal and intrapersonal issues linked with longer-term outcomes are the foundation of EFT, the process-experiential approach. In this paper, evidence in support of EFT as a treatment approach will be reviewed along with research on two mechanisms of change, viewed as central to EFT, clients' emotional processing and the therapeutic relationship conditions. The implications for psychotherapy research are discussed. Given the methodological constraints, there is a need for more innovative methodologies and strategies to investigate specific psychotherapy processes within and across different approaches to map patterns and mechanisms of change to enhance theory, research, practice, and training.

  6. The European water framework directive: water quality classification and implications to engineering planning.

    PubMed

    Achleitner, Stefan; De Toffol, Sara; Engelhard, Carolina; Rauch, Wolfgang

    2005-04-01

    The European Water framework directive (WFD) is probably the most important environmental management directive that has been enacted over the last decade in the European Union. The directive aims at achieving an overall good ecological status in all European water bodies. In this article, we discuss the implementation steps of the WFD and their implications for environmental engineering practice while focusing on rivers as the main receiving waters. Arising challenges for engineers and scientists are seen in the quantitative assessment of water quality, where standardized systems are needed to estimate the biological status. This is equally of concern in engineering planning, where the prediction of ecological impacts is required. Studies dealing with both classification and prediction of the ecological water quality are reviewed. Further, the combined emission-water quality approach is discussed. Common understanding of this combined approach is to apply the most stringent of either water quality or emission standard to a certain case. In contrast, for example, the Austrian water act enables the application of only the water quality based approach--at least on a temporary basis.

  7. Integrating molecular and morphological approaches for characterizing parasite cryptic species: implications for parasitology.

    PubMed

    Nadler, Steven A; DE León, Gerardo Pérez-Ponce

    2011-11-01

    Herein we review theoretical and methodological considerations important for finding and delimiting cryptic species of parasites (species that are difficult to recognize using traditional systematic methods). Applications of molecular data in empirical investigations of cryptic species are discussed from an historical perspective, and we evaluate advantages and disadvantages of approaches that have been used to date. Developments concerning the theory and practice of species delimitation are emphasized because theory is critical to interpretation of data. The advantages and disadvantages of different molecular methodologies, including the number and kind of loci, are discussed relative to tree-based approaches for detecting and delimiting cryptic species. We conclude by discussing some implications that cryptic species have for research programmes in parasitology, emphasizing that careful attention to the theory and operational practices involved in finding, delimiting, and describing new species (including cryptic species) is essential, not only for fully characterizing parasite biodiversity and broader aspects of comparative biology such as systematics, evolution, ecology and biogeography, but to applied research efforts that strive to improve development and understanding of epidemiology, diagnostics, control and potential eradication of parasitic diseases.

  8. Summary Report - Strategic Weapons on the 21st Century Conference

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roberts, B.

    2017-04-21

    This 11th annual event focused on changes in the security environment and their implications for the U.S. approach to deterrence, with special attention to extended deterrence in Europe and East Asia.

  9. Typewriting--Less-Than-a-Semester Credit Basis

    ERIC Educational Resources Information Center

    Schramm, Dwayne

    1974-01-01

    Five advantages to be gained in teaching typing in a time structure less rigid than the traditional semester are itemized. The implications for typewriting teachers as a more individualized approach is used are considered. (AG)

  10. Advancing a New Critical Framework for Transfer Student Research: Implications for Institutional Research

    ERIC Educational Resources Information Center

    Laanan, Frankie Santos; Jain, Dimpal

    2016-01-01

    This chapter explores how critical lenses can be used to conduct transfer research and proposes a new methodological approach to understand the complex experiences and success of diverse transfer students.

  11. Vocational Rehabilitation in Zimbabwe: A Socio-Historical Analysis.

    ERIC Educational Resources Information Center

    Devlieger, Patrick J.

    1998-01-01

    Addresses the legacy of Zimbabwe's missionary and colonial history; the postcolonial period; approaches to employment of people with disabilities; the impact of migration; and new developments throughout Africa and their implications for vocational rehabilitation. (SK)

  12. Education for Sustainability: An Ecological Approach.

    ERIC Educational Resources Information Center

    Companion, Marc

    2002-01-01

    Describes the ecological design in water purification, indoor climate regulation, and repairing polluted bodies of water. Discusses the implications of ecosystems in the classroom in which students study concepts such as homeostasis and self-regulation. (YDS)

  13. A Developmental Approach to Counseling Adults

    ERIC Educational Resources Information Center

    Bocknek, Gene

    1976-01-01

    The author enunciates basic tenets of developmental theory and shows their application to work with adults. Counseling intervention is conceptualized as mobilizing resources to facilitate growth. Implications for the future of counseling psychology are considered. (Author)

  14. System analysis approach to deriving design criteria (Loads) for Space Shuttle and its payloads. Volume 2: Typical examples

    NASA Technical Reports Server (NTRS)

    Ryan, R. S.; Bullock, T.; Holland, W. B.; Kross, D. A.; Kiefling, L. A.

    1981-01-01

    The achievement of an optimized design from the system standpoint under the low cost, high risk constraints of the present day environment was analyzed. Space Shuttle illustrates the requirement for an analysis approach that considers all major disciplines (coupling between structures control, propulsion, thermal, aeroelastic, and performance), simultaneously. The Space Shuttle and certain payloads, Space Telescope and Spacelab, are examined. The requirements for system analysis approaches and criteria, including dynamic modeling requirements, test requirements, control requirements, and the resulting design verification approaches are illustrated. A survey of the problem, potential approaches available as solutions, implications for future systems, and projected technology development areas are addressed.

  15. Explicit and Implicit Approach Motivation Interact to Predict Interpersonal Arrogance

    PubMed Central

    Robinson, Michael D.; Ode, Scott; Spencer L., Palder; Fetterman, Adam K.

    2012-01-01

    Self-reports of approach motivation are unlikely to be sufficient in understanding the extent to which the individual reacts to appetitive cues in an approach-related manner. A novel implicit probe of approach tendencies was thus developed, one that assessed the extent to which positive affective (versus neutral) stimuli primed larger size estimates, as larger perceptual sizes co-occur with locomotion toward objects in the environment. In two studies (total N = 150), self-reports of approach motivation interacted with this implicit probe of approach motivation to predict individual differences in arrogance, a broad interpersonal dimension previously linked to narcissism, antisocial personality tendencies, and aggression. The results of the two studies were highly parallel in that self-reported levels of approach motivation predicted interpersonal arrogance in the particular context of high, but not low, levels of implicit approach motivation. Implications for understanding approach motivation, implicit probes of it, and problematic approach-related outcomes are discussed. PMID:22399360

  16. Explicit and implicit approach motivation interact to predict interpersonal arrogance.

    PubMed

    Robinson, Michael D; Ode, Scott; Palder, Spencer L; Fetterman, Adam K

    2012-07-01

    Self-reports of approach motivation are unlikely to be sufficient in understanding the extent to which the individual reacts to appetitive cues in an approach-related manner. A novel implicit probe of approach tendencies was thus developed, one that assessed the extent to which positive affective (versus neutral) stimuli primed larger size estimates, as larger perceptual sizes co-occur with locomotion toward objects in the environment. In two studies (total N = 150), self-reports of approach motivation interacted with this implicit probe of approach motivation to predict individual differences in arrogance, a broad interpersonal dimension previously linked to narcissism, antisocial personality tendencies, and aggression. The results of the two studies were highly parallel in that self-reported levels of approach motivation predicted interpersonal arrogance in the particular context of high, but not low, levels of implicit approach motivation. Implications for understanding approach motivation, implicit probes of it, and problematic approach-related outcomes are discussed.

  17. Spurious Solutions Of Nonlinear Differential Equations

    NASA Technical Reports Server (NTRS)

    Yee, H. C.; Sweby, P. K.; Griffiths, D. F.

    1992-01-01

    Report utilizes nonlinear-dynamics approach to investigate possible sources of errors and slow convergence and non-convergence of steady-state numerical solutions when using time-dependent approach for problems containing nonlinear source terms. Emphasizes implications for development of algorithms in CFD and computational sciences in general. Main fundamental conclusion of study is that qualitative features of nonlinear differential equations cannot be adequately represented by finite-difference method and vice versa.

  18. Healing the Wounds of War and More: An Integrative Approach to Peace--The Work of Adam Curle and Others with Mir i dobro in Zupanja, Croatia.

    ERIC Educational Resources Information Center

    Mitchels, Barbara

    2003-01-01

    Examines practical implications of Curle's approach to psychological aspects of conflict and peacemaking as evidenced in the Mir i dobro project in Zupanja, taking into consideration some of the current debates concerning treatment of psychological trauma, including validity of the diagnosis of posttraumatic stress disorder and use of so-called…

  19. Optimize scientific communication skills on work and energy concept with implementation of interactive conceptual instruction and multi representation approach

    NASA Astrophysics Data System (ADS)

    Patriot, E. A.; Suhandi, A.; Chandra, D. T.

    2018-05-01

    The ultimate goal of learning in the curriculum 2013 is that learning must improve and balance between soft skills and hard skills of learners. In addition to the knowledge aspect, one of the other skills to be trained in the learning process using a scientific approach is communication skills. This study aims to get an overview of the implementation of interactive conceptual instruction with multi representation to optimize the achievement of students’ scientific communication skills on work and energy concept. The scientific communication skills contains the sub-skills were searching the information, scientific writing, group discussion and knowledge presentation. This study was descriptive research with observation method. Subjects in this study were 35 students of class X in Senior High School at Sumedang. The results indicate an achievement of optimal scientific communication skills. The greatest achievement of KKI based on observation is at fourth meeting of KKI-3, which is a sub-skill of resume writing of 89%. Allmost students responded positively to the implication of interactive conceptual instruction with multi representation approach. It can be concluded that the implication of interactive conceptual instruction with multi representation approach can optimize the achievement of students’ scientific communication skill on work and energy concept.

  20. Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data.

    PubMed

    Nguyen, Tin; Diaz, Diana; Tagett, Rebecca; Draghici, Sorin

    2016-07-12

    MicroRNAs (miRNAs) are small non-coding RNA molecules whose primary function is to regulate the expression of gene products via hybridization to mRNA transcripts, resulting in suppression of translation or mRNA degradation. Although miRNAs have been implicated in complex diseases, including cancer, their impact on distinct biological pathways and phenotypes is largely unknown. Current integration approaches require sample-matched miRNA/mRNA datasets, resulting in limited applicability in practice. Since these approaches cannot integrate heterogeneous information available across independent experiments, they neither account for bias inherent in individual studies, nor do they benefit from increased sample size. Here we present a novel framework able to integrate miRNA and mRNA data (vertical data integration) available in independent studies (horizontal meta-analysis) allowing for a comprehensive analysis of the given phenotypes. To demonstrate the utility of our method, we conducted a meta-analysis of pancreatic and colorectal cancer, using 1,471 samples from 15 mRNA and 14 miRNA expression datasets. Our two-dimensional data integration approach greatly increases the power of statistical analysis and correctly identifies pathways known to be implicated in the phenotypes. The proposed framework is sufficiently general to integrate other types of data obtained from high-throughput assays.

  1. Narrative in interprofessional education and practice: implications for professional identity, provider-patient communication and teamwork.

    PubMed

    Clark, Phillip G

    2014-01-01

    Health and social care professionals increasingly use narrative approaches to focus on the patient and to communicate with each other. Both effective interprofessional education (IPE) and practice (IPP) require recognizing the various values and voices of different professions, how they relate to the patient's life story, and how they interact with each other at the level of the healthcare team. This article analyzes and integrates the literature on narrative to explore: self-narrative as an expression of one's professional identity; the co-creation of the patient's narrative by the professional and the patient; and the interprofessional multi-vocal narrative discourse as co-constructed by members of the healthcare team. Using a narrative approach to thinking about professional identity, provider-patient communication, and interprofessional teamwork expands our thinking about both IPE and IPP by providing new insights into the nature of professional practice based on relationships to oneself, the patient, and others on the team. How professionals define themselves, gather and present information from the patient, and communicate as members of a clinical team all have important dimensions that can be revealed by a narrative approach. Implications and conclusions for the further development of the narrative approach in IPE and IPP are offered.

  2. UNMASKING MASKED HYPERTENSION: PREVALENCE, CLINICAL IMPLICATIONS, DIAGNOSIS, CORRELATES, AND FUTURE DIRECTIONS

    PubMed Central

    Peacock, James; Diaz, Keith M.; Viera, Anthony J.; Schwartz, Joseph E.; Shimbo, Daichi

    2014-01-01

    ‘Masked hypertension’ is defined as having non-elevated clinic blood pressure (BP) with elevated out-of-clinic average BP, typically determined by ambulatory BP monitoring. Approximately 15–30% of adults with non-elevated clinic BP have masked hypertension. Masked hypertension is associated with increased risks of cardiovascular morbidity and mortality compared to sustained normotension (non-elevated clinic and ambulatory BP), which is similar to or approaching the risk associated with sustained hypertension (elevated clinic and ambulatory BP). The confluence of increased cardiovascular risk and a failure to be diagnosed by the conventional approach of clinic BP measurement makes masked hypertension a significant public health concern. However, many important questions remain. First, the definition of masked hypertension varies across studies. Further, the best approach in the clinical setting to exclude masked hypertension also remains unknown. It is unclear whether home BP monitoring is an adequate substitute for ambulatory BP monitoring in identifying masked hypertension. Few studies have examined the mechanistic pathways that may explain masked hypertension. Finally, scarce data are available on the best approach to treating individuals with masked hypertension. Herein, we review the current literature on masked hypertension including definition, prevalence, clinical implications, special patient populations, correlates, issues related to diagnosis, treatment, and areas for future research. PMID:24573133

  3. [Some insights on the influence of socioeconomic factors on migratory movements].

    PubMed

    Gordillo, J

    1981-01-01

    A theoretical approach to the study of migration in Ecuador is presented. Consideration is also given to the relationships among migration, mortality, fertility, and employment and to the policy implications of these relationships.

  4. A relational framework for understanding bullying: Developmental antecedents and outcomes.

    PubMed

    Rodkin, Philip C; Espelage, Dorothy L; Hanish, Laura D

    2015-01-01

    This article reviews current research on the relational processes involved in peer bullying, considering developmental antecedents and long-term consequences. The following themes are highlighted: (a) aggression can be both adaptive and maladaptive, and this distinction has implications for bullies' functioning within peer social ecologies; (b) developmental antecedents and long-term consequences of bullying have not been well-distinguished from the extant research on aggressive behavior; (c) bullying is aggression that operates within relationships of power and abuse. Power asymmetry and repetition elements of traditional bullying definitions have been hard to operationalize, but without these specifications and more dyadic measurement approaches there may be little rationale for a distinct literature on bullying--separate from aggression. Applications of a relational approach to bullying are provided using gender as an example. Implications for future research are drawn from the study of relationships and interpersonal theories of developmental psychopathology. (c) 2015 APA, all rights reserved).

  5. Recent biologic and genetic advances in neuroblastoma: Implications for diagnostic, risk stratification, and treatment strategies.

    PubMed

    Newman, Erika A; Nuchtern, Jed G

    2016-10-01

    Neuroblastoma is an embryonic cancer of neural crest cell lineage, accounting for up to 10% of all pediatric cancer. The clinical course is heterogeneous ranging from spontaneous regression in neonates to life-threatening metastatic disease in older children. Much of this clinical variance is thought to result from distinct pathologic characteristics that predict patient outcomes. Consequently, many research efforts have been focused on identifying the underlying biologic and genetic features of neuroblastoma tumors in order to more clearly define prognostic subgroups for treatment stratification. Recent technological advances have placed emphasis on the integration of genetic alterations and predictive biologic variables into targeted treatment approaches to improve patient survival outcomes. This review will focus on these recent advances and the implications they have on the diagnostic, staging, and treatment approaches in modern neuroblastoma clinical management. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Cisgenics - A Sustainable Approach for Crop Improvement

    PubMed Central

    Telem, R.S.; Wani, Shabir. H.; Singh, N.B.; Nandini, R.; Sadhukhan, R.; Bhattacharya, S.; Mandal, N.

    2013-01-01

    The implication of molecular biology in crop improvement is now more than three decades old. Not surprisingly, technology has moved on, and there are a number of new techniques that may or may not come under the genetically modified (GM) banner and, therefore, GM regulations. In cisgenic technology, cisgenes from crossable plants are used and it is a single procedure of gene introduction whereby the problem of linkage drag of other genes is overcome. The gene used in cisgenic approach is similar compared with classical breeding and cisgenic plant should be treated equally as classically bred plant and differently from transgenic plants. Therefore, it offers a sturdy reference to treat cisgenic plants similarly as classically bred plants, by exemption of cisgenesis from the current GMO legislations. This review covers the implications of cisgenesis towards the sustainable development in the genetic improvement of crops and considers the prospects for the technology. PMID:24396278

  7. Diverse types of genetic variation converge on functional gene networks involved in schizophrenia.

    PubMed

    Gilman, Sarah R; Chang, Jonathan; Xu, Bin; Bawa, Tejdeep S; Gogos, Joseph A; Karayiorgou, Maria; Vitkup, Dennis

    2012-12-01

    Despite the successful identification of several relevant genomic loci, the underlying molecular mechanisms of schizophrenia remain largely unclear. We developed a computational approach (NETBAG+) that allows an integrated analysis of diverse disease-related genetic data using a unified statistical framework. The application of this approach to schizophrenia-associated genetic variations, obtained using unbiased whole-genome methods, allowed us to identify several cohesive gene networks related to axon guidance, neuronal cell mobility, synaptic function and chromosomal remodeling. The genes forming the networks are highly expressed in the brain, with higher brain expression during prenatal development. The identified networks are functionally related to genes previously implicated in schizophrenia, autism and intellectual disability. A comparative analysis of copy number variants associated with autism and schizophrenia suggests that although the molecular networks implicated in these distinct disorders may be related, the mutations associated with each disease are likely to lead, at least on average, to different functional consequences.

  8. Impressions of Danger Influence Impressions of People: An Evolutionary Perspective on Individual and Collective Cognition

    PubMed Central

    Schaller, Mark; Faulkner, Jason; Park, Justin H.; Neuberg, Steven L.; Kenrick, Douglas T.

    2011-01-01

    An evolutionary approach to social cognition yields novel hypotheses about the perception of people belonging to specific kinds of social categories. These implications are illustrated by empirical results linking the perceived threat of physical injury to stereotypical impressions of outgroups. We review a set of studies revealing several ways in which threat-connoting cues influence perceptions of ethnic outgroups and the individuals who belong to those outgroups. We also present new results that suggest additional implications of evolved danger-avoidance mechanisms on interpersonal communication and the persistence of cultural-level stereotypes about ethnic outgroups. The conceptual utility of an evolutionary approach is further illustrated by a parallel line of research linking the threat of disease to additional kinds of social perceptions and behaviors. Evolved danger-avoidance mechanisms appear to contribute in diverse ways to individual-level cognitive processes, as well as to culturally-shared collective beliefs. PMID:21874126

  9. Integrated approaches to perceptual learning.

    PubMed

    Jacobs, Robert A

    2010-04-01

    New technologies and new ways of thinking have recently led to rapid expansions in the study of perceptual learning. We describe three themes shared by many of the nine articles included in this topic on Integrated Approaches to Perceptual Learning. First, perceptual learning cannot be studied on its own because it is closely linked to other aspects of cognition, such as attention, working memory, decision making, and conceptual knowledge. Second, perceptual learning is sensitive to both the stimulus properties of the environment in which an observer exists and to the properties of the tasks that the observer needs to perform. Moreover, the environmental and task properties can be characterized through their statistical regularities. Finally, the study of perceptual learning has important implications for society, including implications for science education and medical rehabilitation. Contributed articles relevant to each theme are summarized. Copyright © 2010 Cognitive Science Society, Inc.

  10. Variations in aseptic technique and implications for infection control.

    PubMed

    Aziz, Anne Marie

    Healthcare-acquired infections (HAIs) are a serious concern, costing the NHS 1 billion pounds a year and causing 5000 deaths annually despite increased funding. A contributing factor is the variety of aseptic techniques in use in different hospitals and even within a single hospital. These cause problems for healthcare workers as well as increasing the risk of HAI. This article examines a number of traditional approaches to aseptic technique, highlighting their differences and the implications for infection control. It concludes that improvement in aseptic technique could be achieved by implementation of a single unified approach to aseptic technique that can be standardized and audited annually, such as the aseptic non-touch technique (ANTT), which has been recommended for adoption throughout the UK. It ends with suggestions for measures that could be introduced and strengthened to improve aseptic technique, and ultimately reduce the rate of HAI.

  11. Innate immunity in HIV infection and implications for vaccine design: a summary of the workshop held at the National Institute of Allergy and Infectious Diseases, Bethesda on February 25-26, 2010.

    PubMed

    Bansal, Geetha P; Leitner, Wolfgang W

    2010-12-06

    The search for an effective HIV vaccine continues to be a challenge. Several candidates have been tested in preclinical protocols, and a few have been tested in clinical trials without resounding success. It is unclear why vaccine approaches to control HIV infection have been unsuccessful, but opportunities to dissect the causes for the failure have surfaced from recent work on the virology, immunology and pathogenesis of HIV and from analysis of vaccine studies. The significance of the innate immune system in HIV infection may provide new paths to discover effective approaches. This report summarizes a workshop held to discuss the role of selected aspects of innate immunity to viral infections and successful vaccines that may have important implications for designing effective HIV vaccines. Copyright © 2010. Published by Elsevier Ltd.. All rights reserved.

  12. Beyond Utterances: Distributed Cognition as a Framework for Studying Discourse in Adults with Acquired Brain Injury

    PubMed Central

    Duff, Melissa C.; Mutlu, Bilge; Byom, Lindsey; Turkstra, Lyn S.

    2014-01-01

    Considerable effort has been directed at understanding the nature of the communicative deficits observed in individuals with acquired brain injuries. Yet several theoretical, methodological, and clinical challenges remain. In this article, we examine distributed cognition as a framework for understanding interaction among communication partners, interaction of communication and cognition, and interaction with the environments and contexts of everyday language use. We review the basic principles of distributed cognition and the implications for applying this approach to the study of discourse in individuals with cognitive-communication disorders. We also review a range of protocols and findings from our research that highlight how the distributed cognition approach might offer a deeper understanding of communicative mechanisms and deficits in individuals with cognitive communication impairments. The advantages and implications of distributed cognition as a framework for studying discourse in adults with acquired brain injury are discussed. PMID:22362323

  13. Global Perspectives on Cancer Health Disparities: Impact, Utility, and Implications for Cancer Nursing

    PubMed Central

    So, Winnie K. W.; Chan, Raymond Javan; Truant, Tracy; Trevatt, Paul; Bialous, Stella Aguinaga; Barton-Burke, Margaret

    2016-01-01

    This paper examines cancer health disparities and contributing factors at national, regional, and international levels. The authors all live in different countries and regions with different health-care systems and practices. Despite the shared cancer nursing perspective, each country or global region approaches cancer disparities differently. With globalization the world is becoming smaller, and in turn becoming interconnected and interdependent. This article focuses on cancer health disparities and global cancer nursing, exemplifying these concepts about the impact and implications of person-centered care. PMID:28083548

  14. Nonlinear Time Delayed Feedback Control of Aeroelastic Systems: A Functional Approach

    NASA Technical Reports Server (NTRS)

    Marzocca, Piergiovanni; Librescu, Liviu; Silva, Walter A.

    2003-01-01

    In addition to its intrinsic practical importance, nonlinear time delayed feedback control applied to lifting surfaces can result in interesting aeroelastic behaviors. In this paper, nonlinear aeroelastic response to external time-dependent loads and stability boundary for actively controlled lifting surfaces, in an incompressible flow field, are considered. The structural model and the unsteady aerodynamics are considered linear. The implications of the presence of time delays in the linear/nonlinear feedback control and of geometrical parameters on the aeroelasticity of lifting surfaces are analyzed and conclusions on their implications are highlighted.

  15. Utility of the Electrocardiogram in Drug Overdose and Poisoning: Theoretical Considerations and Clinical Implications

    PubMed Central

    Yates, Christopher; Manini, Alex F

    2012-01-01

    The ECG is a rapidly available clinical tool that can help clinicians manage poisoned patients. Specific myocardial effects of cardiotoxic drugs have well-described electrocardiographic manifestations. In the practice of clinical toxicology, classic ECG changes may hint at blockade of ion channels, alterations of adrenergic tone, or dysfunctional metabolic activity of the myocardium. This review will offer a structured approach to ECG interpretation in poisoned patients with a focus on clinical implications and ECG-based management recommendations in the initial evaluation of patients with acute cardiotoxicity. PMID:22708912

  16. Nurse education: a feminist approach.

    PubMed

    Chapman, E

    1997-06-01

    Nursing is predominantly a female profession. This paper seeks to explore the implications of this for curriculum design and suggests that insights from feminist theory should be applied to curricula. To insert the 'subject' of feminism into the curriculum is different from allowing its theories to affect the design of the curriculum itself. The paper seeks to justify such a change and asks what the resulting characteristics would be. Would such a curriculum change succeed and what would be its limitations? The paper concludes by highlighting the implications for nurse education.

  17. Diagnosing Autism in Individuals with Known Genetic Syndromes: Clinical Considerations and Implications for Intervention

    PubMed Central

    Hepburn, Susan L.; Moody, Eric J.

    2015-01-01

    Assessing symptoms of autism in persons with known genetic syndromes associated with intellectual and/or developmental disability is a complex clinical endeavor. We suggest that a developmental approach to evaluation is essential to reliably teasing apart global impairments from autism-specific symptomology. In this chapter, we discuss our assumptions about autism spectrum disorders, the process of conducting a family-focused, comprehensive evaluation with behaviorally complex children and some implications for intervention in persons with co-occurring autism and known genetic syndromes. PMID:26269783

  18. Should the capability approach be applied in health economics?

    PubMed

    Coast, Joanna; Smith, Richard; Lorgelly, Paula

    2008-06-01

    This editorial questions the implications of the capability approach for health economics. Two specific issues are considered: the evaluative space of capablities (as opposed to health or utility) and the decision-making principle of maximisation. The paper argues that the capability approach can provide a richer evaluative space enabling improved evaluation of many interventions. It also argues that more thought is needed about the decision-making principles both within the capability approach and within health economics more generally. Specifically, researchers should analyse equity-oriented principles such as equalisation and a 'decent minimum' of capability, rather than presuming that the goal must be the maximisation of capability.

  19. Communication strategies in cosmetic surgery websites: an application of Taylor's six-segment message strategy wheel.

    PubMed

    Ahn, Ho-Young Anthony; Wu, Lei; Taylor, Ronald E

    2013-01-01

    Using Taylor's six-segment message strategy wheel as a theoretical framework, this study examines the communication approach (transmission or ritual) and message strategy (ego, social, sensory, routine, acute need, or ration) of cosmetic surgery websites. A content analysis revealed a fairly even division between transmission and ritual approaches. Ration strategy was the exclusive strategy in the websites adopting a transmission approach. No routine or acute need strategies were observed. Websites incorporating the ritual approach used ego, social, and sensory strategies. Human female models and natural objects were incorporated to deliver emotional persuasion. Implications for cosmetic surgery web marketers are discussed.

  20. The data base management system alternative for computing in the human services.

    PubMed

    Sircar, S; Schkade, L L; Schoech, D

    1983-01-01

    The traditional incremental approach to computerization presents substantial problems as systems develop and grow. The Data Base Management System approach to computerization was developed to overcome the problems resulting from implementing computer applications one at a time. The authors describe the applications approach and the alternative Data Base Management System (DBMS) approach through their developmental history, discuss the technology of DBMS components, and consider the implications of choosing the DBMS alternative. Human service managers need an understanding of the DBMS alternative and its applicability to their agency data processing needs. The basis for a conscious selection of computing alternatives is outlined.

  1. Robosphere: Self Sustaining Robotic Ecologies as Precursors to Human Planetary Exploration

    NASA Technical Reports Server (NTRS)

    Colombano, Silvano P.

    2003-01-01

    The present sequential mission oriented approach to robotic planetary exploration, could be changed to an infrastructure building approach where a robotic presence is permanent, self sustaining and growing with each mission. We call this self-sustaining robotic ecology approach robosphere and discuss the technological issues that need to be addressed before this concept can be realized. One of the major advantages of this approach is that a robosphere would include much of the infrastructure required by human explorers and would thus lower the preparation and risk threshold inherent in the transition from robotic to human exploration. In this context we discuss some implications for space architecture.

  2. Policy directions in urban health in developing countries--the slum improvement approach.

    PubMed

    Harpham, T; Stephens, C

    1992-07-01

    The urban development, or housing, sector has a longer experience of addressing the problems of the urban poor in developing countries than the health sector. In recent years the policy of 'slum improvement', which involves both sectors, has attracted the support of international donors. This article documents the development of the slum improvement approach and addresses key issues of the approach which have implications for health planning: covering the poorest dwellers; relocation; land tenure; gentrification; debt burdens and the impact on women. Questions about the approach which still need answering are defined and a summary of the constraints in slum improvement and potential solutions is presented.

  3. Understanding Mental Illness Stigma Toward Persons With Multiple Stigmatized Conditions: Implications of Intersectionality Theory.

    PubMed

    Oexle, Nathalie; Corrigan, Patrick W

    2018-05-01

    People with mental illness are often members of multiple stigmatized social groups. Therefore, experienced disadvantage might not be determined solely by mental illness stigma. Nevertheless, most available research does not consider the effects and implications of membership in multiple stigmatized social groups among people with mental illness. Reflecting on intersectionality theory, the authors discuss two intersectional effects determining disadvantage among people with mental illness who are members of multiple stigmatized social groups, namely double disadvantage and prominence. To be effective, interventions to reduce disadvantage experienced by people with mental illness need to be flexible and targeted rather than universal in order to address the implications of intersectionality. Whereas education-based approaches usually assume homogeneity and use universal strategies, contact-based interventions consider diversity among people with mental illness.

  4. The Safer Delivery of Surgical Services Program (S3): Explaining Its Differential Effectiveness and Exploring Implications for Improving Quality in Complex Systems.

    PubMed

    Flynn, Lorna C; McCulloch, Peter G; Morgan, Lauren J; Robertson, Eleanor R; New, Steve J; Stedman, Francesca E; Martin, Graham P

    2016-12-01

    To analyze the challenges encountered during surgical quality improvement interventions, and explain the relative success of different intervention strategies. Understanding why and how interventions work is vital for developing improvement science. The S3 Program of studies tested whether combining interventions addressing culture and system was more likely to result in improvement than either approach alone. Quantitative results supported this theory. This qualitative study investigates why this happened, what aspects of the interventions and their implementation most affected improvement, and the implications for similar programs. Semistructured interviews were conducted with hospital staff (23) and research team members (11) involved in S3 studies. Analysis was based on the constant comparative method, with coding conducted concurrently with data collection. Themes were identified and developed in relation to the program theory behind S3. The superior performance of combined intervention over single intervention arms appeared related to greater awareness and ability to act, supporting the S3 hypothesis. However, we also noted unforeseen differences in implementation that seemed to amplify this difference. The greater ambition and more sophisticated approach in combined intervention arms resulted in requests for more intensive expert support, which seemed crucial in their success. The contextual challenges encountered have potential implications for the replicability and sustainability of the approach. Our findings support the S3 hypothesis, triangulating with quantitative results and providing an explanatory account of the causal relationship between interventions and outcomes. They also highlight the importance of implementation strategies, and of factors outside the control of program designers.

  5. Revisiting Ramakrishnan's approach to relatively. [Velocity addition theorem uniqueness

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nandi, K.K.; Shankara, T.S.

    The conditions under which the velocity addition theorem (VAT) is formulated by Ramakrishnan gave rise to doubts about the uniqueness of the theorem. These conditions are rediscussed with reference to their algebraic and experimental implications. 9 references.

  6. Implications of Lean Manufacturing for Human Resource Strategy.

    ERIC Educational Resources Information Center

    Forrester, Rosalind

    1995-01-01

    Lean production changes organizational style and structure, roles of team leaders and members, training needs, problem-solving approaches, labor relations, and pay practices. The profound cultural changes it causes may trigger defenses that cause it to fail. (SK)

  7. Action-Oriented Research: Models and Methods.

    ERIC Educational Resources Information Center

    Small, Stephen A.

    1995-01-01

    Four models of action-oriented research, a research approach that can inform policy and practice, are described: action, participatory, empowerment, and feminism research. Discusses historical roots, epistemological assumptions, agendas, and methodological strategies of each, and presents implications for family researchers. (JPS)

  8. Internet-Mediated Learning in Public Affairs Programs: Issues and Implications.

    ERIC Educational Resources Information Center

    Rahm, Dianne; Reed, B. J.; Rydl, Teri L.

    1999-01-01

    An overview of Internet-mediated learning in public affairs programs identifies issues for faculty, students, and administrators, including intellectual property rights, instructional issues, learning approaches, student expectations, logistics and support, complexity of coordination, and organizational control. (DB)

  9. Research News: Debate on Learning Theory Is Shifting.

    ERIC Educational Resources Information Center

    Fox, Jeffrey L.

    1983-01-01

    Discusses current learning theories, indicating that though many psychologists and ethologists now agree on using a mechanistic approach, some linguists doubt its adequacy. Implications of research on the mollusk "Aplasia" to understand the learning process are included. (JN)

  10. Assessing environmental quality: the implications for social justice

    EPA Science Inventory

    Individuals experience simultaneous exposure to pollutants and social factors, which cluster to affect human health outcomes. The optimal approach to combining these factors is unknown, therefore we developed a method to model simultaneous exposure using criteria air pollutants, ...

  11. Stark laws and fair market value exceptions: an introduction.

    PubMed

    Siebrasse, Paul B

    2007-01-01

    This article will focus on one aspect of complexity in modern healthcare, namely the implications of Stark laws and other fraud and abuse provisions, including anti-kickback statutes and HIPAA. Also, this article explores the prevalence of fair market value as an exception in the Stark laws and discusses the meanings of those exceptions. Finally, the article explores basic approaches to assessing fair market value, including cost, income, and marketing approaches.

  12. Human Factors Implications and Issues in Network Enabled Operations

    DTIC Science & Technology

    2006-08-28

    même par des soldats individuels. L’armée de mer, quant à elle, évolue dans un environnement de complexité moyenne comparativement aux forces...approach found in most of the derivatives of NCW because the FORCEnet paper states that in the design of this new approach to warfare and other...defects mentality, risk aversion, poorly designed war fighting experiments, and widespread contentment with current performance, expectations for NCW will

  13. Clarity and strength of implications for practice in medical journal articles: an exploratory analysis

    PubMed Central

    Owens, Allessia P; Bartunek, Jean M

    2011-01-01

    Objective To examine how leading clinical journals report research findings, aiming to assess how they frame their implications for medical practice and to compare that literature's patterns with those of the management literature. Data Source Clinically relevant research articles from three leading clinical journals (N Engl J Med, JAMA, and Ann Intern Med). Methods Review of wording of a sequential sample from 2010, with categorisation, comparison among journals, and comparison with management literature. Results Clinical journals usually state that one approach did or did not differ from another approach (35 of 51 articles, 68.6%), but they recommended a specific course of action (‘therefore, x should be done’) in just 25.5%. One article gave instruction on how to implement the changes. Two-thirds of the reports called for further research. Half used tentative language. Management research articles nearly always specified who should use the information and drew from over 60 types of potential users, whereas the clinical literature named the audience in only 23.5% of clinicians. Conclusions Authors and editors of the clinical literature could test being more clear and direct in presenting implications of research findings for practice, including stating when the findings do not justify changes in practice. PMID:21450773

  14. Intersubjective Culture: The Role of Intersubjective Perceptions in Cross-Cultural Research.

    PubMed

    Chiu, Chi-Yue; Gelfand, Michele J; Yamagishi, Toshio; Shteynberg, Garriy; Wan, Ching

    2010-07-01

    Intersubjective perceptions refer to shared perceptions of the psychological characteristics that are widespread within a culture. In this article, we propose the intersubjective approach as a new approach to understanding the role that culture plays in human behavior. In this approach, intersubjective perceptions, which are distinct from personal values and beliefs, mediate the effect of the ecology on individuals' responses and adaptations. We review evidence that attests to the validity and utility of the intersubjective approach in explicating culture's influence on human behaviors and discuss the implications of this approach for understanding the interaction between the individual, ecology, and culture; the nature of cultural competence; management of multicultural identities; cultural change; and measurement of culture. © The Author(s) 2010.

  15. Dealing With the Long-Term Social Implications of Research

    PubMed Central

    Fleischman, Alan; Levine, Carol; Eckenwiler, Lisa; Grady, Christine; Hammerschmidt, Dale E.; Sugarman, Jeremy

    2016-01-01

    Biomedical and behavioral research may affect strongly held social values and thereby create significant controversy over whether such research should be permitted in the first place. Institutional review boards (IRBs) responsible for protecting the rights and welfare of participants in research are sometimes faced with review of protocols that have significant implications for social policy and the potential for negative social consequences. Although IRB members often raise concerns about potential long-term social implications in protocol review, federal regulations strongly discourage IRBs from considering them in their decisions. Yet IRBs often do consider the social implications of research protocols and sometimes create significant delays in initiating or even prevent such research. The social implications of research are important topics for public scrutiny and professional discussion. This article examines the reasons that the federal regulations preclude IRBs from assessing the social risks of research, and examines alternative approaches that have been used with varying success by national advisory groups to provide such guidance. The article concludes with recommendations for characteristics of a national advisory group that could successfully fulfill this need, including sustainability, independence, diverse and relevant expertise, and public transparency. PMID:21534138

  16. PERFORMANCE AND ANALYSIS OF AQUIFER TESTS WITH IMPLICATIONS FOR CONTAMINANT TRANSPORT MODELING

    EPA Science Inventory

    The scale-dependence of dispersivity values used in contaminant transport models to estimate the spreading of contaminant plumes by hydrodynamic dispersion processes was investigated and found to be an artifact of conventional modeling approaches (especially, vertically averaged ...

  17. HUMAN CLINICAL STUDIES OF CONCENTRATED AMBIENT ULTRAFINE AND FINE PARTICLES

    EPA Science Inventory

    Confirmation of our hypothesis that exposure to ambient ultrafine and fine particles promotes coagulation and alters cardiac function will have important implications for air pollution regulatory efforts, and will provide new approaches for the prevention of cardiovascular hea...

  18. The Destiny of Cells: Mechanisms and Implications of Senescence.

    ERIC Educational Resources Information Center

    Cristofalo, Vincent J.

    1985-01-01

    Approaches the regulation of aging by perturbing the rate of senescent changes in studying how the modulating agent exerts its effects. Shows that very subtle molecular changes may be involved in the overall regulation of cellular aging. (Author/BL)

  19. Technological Strategies and National Purpose

    ERIC Educational Resources Information Center

    Gilpin, Robert

    1970-01-01

    Discusses the international and domestic implications of technological growth. Defines three basic national strategies: a broad front approach, scientific and technological specialization and importation. Analyzes the strategies followed by form countries - France, the United States, Sweden, and Japan- to illustrate the alternatives and the…

  20. Implications of Attachment Theory and Neuroscience for the Psychotherapeutic Treatment of Obesity and Overeating.

    PubMed

    Weiss, Fran

    2018-05-07

    This article examines psychological sequelae underlying dysregulated eating in the overweight and obese patient and proposes a psychotherapy approach informed by classical and modern attachment theory, developmental trauma, and neuroscience to address these structural deficits.

  1. Gestalt Therapy and the Cousellor

    ERIC Educational Resources Information Center

    Peavy, R. Vance

    1973-01-01

    The article briefly describes the principal values in Gestalt Therapy and outlines some of the practices commonly employed in Gestalt work. Implications for counsellors are suggested--both as a mode of counsellor training and as an approach to be used by counsellors. (Author)

  2. Trainee Characteristics and Perceptions of HIV/AIDS Training Quality.

    ERIC Educational Resources Information Center

    Panter, A. T.; Huba, G. J.; Melchior, Lisa A.; Anderson, Donna; Driscoll, Mary; German, Victor F.; Henderson, Harold; Henderson, Ron; Lalonde, Bernadette; Uldall, Karnina K.; Zalumas, Jacqueline

    2000-01-01

    Reports findings from 7 HIV/AIDS education and training projects involving more than 600 training sessions. Trainee characteristics were related to their assessments of training quality, using a regression decision-tree analytic approach. Discusses implications for curriculum development. (SLD)

  3. Executive Impairment Determines ADHD Medication Response: Implications for Academic Achievement

    ERIC Educational Resources Information Center

    Hale, James B.; Reddy, Linda A.; Semrud-Clikeman, Margaret; Hain, Lisa A.; Whitaker, James; Morley, Jessica; Lawrence, Kyle; Smith, Alex; Jones, Nicole

    2011-01-01

    Methylphenidate (MPH) often ameliorates attention-deficit/hyperactivity disorder (ADHD) behavioral dysfunction according to "indirect" informant reports and rating scales. The standard of care behavioral MPH titration approach seldom includes "direct" neuropsychological or academic assessment data to determine treatment…

  4. Psychological Ramifications of Adoption and Implications for Counseling.

    ERIC Educational Resources Information Center

    Helwig, Andrew A.; Ruthven, Dorothy H.

    1990-01-01

    Examines adoption issues including family member loss, infertility, transracial adoptions, special-needs adoptions, older child adoption, inherited traits, adoptive family, biological parents, and open adoption. Suggests specific therapeutic interventions including redefinition, use of paradox, family therapy approaches, group therapy, and…

  5. Inflammatory Role of Macrophage Xanthine Oxidoreductase in Pulmonary Hypertension: Implications for Novel Therapeutic Approaches

    DTIC Science & Technology

    2015-10-01

    Lung Inflammation, Uric Acid, Chronic Obstructive Pulmonary Disease, Mononuclear Phagocyte , Monosodium Urate, XOR WT, XOR KO, Wistar Kyoto, Pulmonary...0451 Annual Report (Year 1) 4 Mononuclear Phagocyte XOR Activity and Superoxide Generation Were Reduced by

  6. A neuropsychoanalytical approach to the hard problem of consciousness.

    PubMed

    Solms, Mark

    2014-06-01

    A neuropsychoanalytical approach to the hard problem of consciousness revolves around the distinction between the subject of consciousness and objects of consciousness. In contrast to the mainstream of cognitive science, neuropsychoanalysis prioritizes the subject. The subject of consciousness is the indispensable page upon which consciousness of objects is inscribed. This has implications for our conception of the mental. The subjective being of consciousness is not registered in the classical exteroceptive modalities; it is not merely a cognitive representation, not only a memory trace. Rather, the exteroceptive modalities are registered in the subjective being. Cognitive representations are mental solids embedded within subjectivity, the tangible and visible (etc) properties of which are projected onto reality. It is important to recognize that mental solids (e.g., the body-as-object) are no more real than the subjective being they are inscribed in (the body-as-subject). Moreover, pure subjectivity is not without content or quality. This aspect of consciousness is conventionally described quantitatively as the level of consciousness, or wakefulness. But it feels like something to be awake. The primary modality of this aspect of consciousness is affect. Affect supplies the subjectivity that underpins all consciousness. Some implications of this approach are discussed here, in broad brush strokes.

  7. The research agenda for general practice/family medicine and primary health care in Europe. Part 3. Results: person centred care, comprehensive and holistic approach.

    PubMed

    Van Royen, Paul; Beyer, Martin; Chevallier, Patrick; Eilat-Tsanani, Sophia; Lionis, Christos; Peremans, Lieve; Petek, Davorina; Rurik, Imre; Soler, Jean Karl; Stoffers, Henri E J H; Topsever, Pinar; Ungan, Mehmet; Hummers-Pradier, Eva

    2010-06-01

    The recently published 'Research Agenda for General Practice/Family Medicine and Primary Health Care in Europe' summarizes the evidence relating to the core competencies and characteristics of the Wonca Europe definition of GP/FM, and its implications for general practitioners/family doctors, researchers and policy makers. The European Journal of General Practice publishes a series of articles based on this document. In a first article, background, objectives, and methodology were discussed. In a second article, the results for the two core competencies 'primary care management' and 'community orientation' were presented. This article reflects on the three core competencies, which deal with person related aspects of GP/FM, i.e. 'person centred care', 'comprehensive approach' and 'holistic approach'. Though there is an important body of opinion papers and (non-systematic) reviews, all person related aspects remain poorly defined and researched. Validated instruments to measure these competencies are lacking. Concerning patient-centredness, most research examined patient and doctor preferences and experiences. Studies on comprehensiveness mostly focus on prevention/care of specific diseases. For all domains, there has been limited research conducted on its implications or outcomes.

  8. A Social Work Approach to Policy: Implications for Population Health

    PubMed Central

    Bazzi, Angela R.; Allen, Heidi L.; Martinson, Melissa L.; Salas-Wright, Christopher P.; Jantz, Kathryn; Crevi, Katherine; Rosenbloom, David L.

    2017-01-01

    The substantial disparities in health and poorer outcomes in the United States relative to peer nations suggest the need to refocus health policy. Through direct contact with the most vulnerable segments of the population, social workers have developed an approach to policy that recognizes the importance of the social environment, the value of social relationships, and the significance of value-driven policymaking. This approach could be used to reorient health, health care, and social policies. Accordingly, social workers can be allies to public health professionals in efforts to eliminate disparities and improve population health. PMID:29236535

  9. A Social Work Approach to Policy: Implications for Population Health.

    PubMed

    Miller, Daniel P; Bazzi, Angela R; Allen, Heidi L; Martinson, Melissa L; Salas-Wright, Christopher P; Jantz, Kathryn; Crevi, Katherine; Rosenbloom, David L

    2017-12-01

    The substantial disparities in health and poorer outcomes in the United States relative to peer nations suggest the need to refocus health policy. Through direct contact with the most vulnerable segments of the population, social workers have developed an approach to policy that recognizes the importance of the social environment, the value of social relationships, and the significance of value-driven policymaking. This approach could be used to reorient health, health care, and social policies. Accordingly, social workers can be allies to public health professionals in efforts to eliminate disparities and improve population health.

  10. A stochastic approach to uncertainty quantification in residual moveout analysis

    NASA Astrophysics Data System (ADS)

    Johng-Ay, T.; Landa, E.; Dossou-Gbété, S.; Bordes, L.

    2015-06-01

    Oil and gas exploration and production relies usually on the interpretation of a single seismic image, which is obtained from observed data. However, the statistical nature of seismic data and the various approximations and assumptions are sources of uncertainties which may corrupt the evaluation of parameters. The quantification of these uncertainties is a major issue which supposes to help in decisions that have important social and commercial implications. The residual moveout analysis, which is an important step in seismic data processing is usually performed by a deterministic approach. In this paper we discuss a Bayesian approach to the uncertainty analysis.

  11. Lead discovery and chemical biology approaches targeting the ubiquitin proteasome system.

    PubMed

    Akinjiyan, Favour A; Carbonneau, Seth; Ross, Nathan T

    2017-10-15

    Protein degradation is critical for proteostasis, and the addition of polyubiquitin chains to a substrate is necessary for its recognition by the 26S proteasome. Therapeutic intervention in the ubiquitin proteasome system has implications ranging from cancer to neurodegeneration. Novel screening methods and chemical biology tools for targeting E1-activating, E2-conjugating and deubiquitinating enzymes will be discussed in this review. Approaches for targeting E3 ligase-substrate interactions as well as the proteasome will also be covered, with a focus on recently described approaches. Copyright © 2017. Published by Elsevier Ltd.

  12. Ionic transport in high-energy-density matter

    DOE PAGES

    Stanton, Liam G.; Murillo, Michael S.

    2016-04-08

    Ionic transport coefficients for dense plasmas have been numerically computed using an effective Boltzmann approach. Here, we developed a simplified effective potential approach that yields accurate fits for all of the relevant cross sections and collision integrals. These results have been validated with molecular-dynamics simulations for self-diffusion, interdiffusion, viscosity, and thermal conductivity. Molecular dynamics has also been used to examine the underlying assumptions of the Boltzmann approach through a categorization of behaviors of the velocity autocorrelation function in the Yukawa phase diagram. By using a velocity-dependent screening model, we examine the role of dynamical screening in transport. Implications of thesemore » results for Coulomb logarithm approaches are discussed.« less

  13. Leadership for long-duration space missions: A shift toward a collective approach

    NASA Astrophysics Data System (ADS)

    Mulhearn, Tyler; McIntosh, Tristan; Gibson, Carter; Mumford, Michael D.; Yammarino, Francis J.; Connelly, Shane; Day, Eric Anthony; Vessey, Brandon

    2016-12-01

    For many years, leadership operations within the National Aeronautics and Space Administration (NASA) have utilized a primarily hierarchical approach. In the present effort, we investigated the leadership needs and considerations given the increased interest in and potential for long-duration space exploration. Specifically, it is argued that a collective leadership approach in which leadership is shared and distributed based on expertise would be beneficial for these types of missions. Interviews were conducted with eleven subject matter experts with wide-ranging experience in NASA and its missions. A mixed-methods analytic approach applied to these interviews provided support for the viability of a collective leadership framework. Implications for NASA and other similar organizational contexts are discussed.

  14. Time-dependent variational approach in terms of squeezed coherent states: Implication to semi-classical approximation

    NASA Technical Reports Server (NTRS)

    Tsue, Yasuhiko

    1994-01-01

    A general framework for time-dependent variational approach in terms of squeezed coherent states is constructed with the aim of describing quantal systems by means of classical mechanics including higher order quantal effects with the aid of canonicity conditions developed in the time-dependent Hartree-Fock theory. The Maslov phase occurring in a semi-classical quantization rule is investigated in this framework. In the limit of a semi-classical approximation in this approach, it is definitely shown that the Maslov phase has a geometric nature analogous to the Berry phase. It is also indicated that this squeezed coherent state approach is a possible way to go beyond the usual WKB approximation.

  15. Clinical judgement in the era of big data and predictive analytics.

    PubMed

    Chin-Yee, Benjamin; Upshur, Ross

    2018-06-01

    Clinical judgement is a central and longstanding issue in the philosophy of medicine which has generated significant interest over the past few decades. In this article, we explore different approaches to clinical judgement articulated in the literature, focusing in particular on data-driven, mathematical approaches which we contrast with narrative, virtue-based approaches to clinical reasoning. We discuss the tension between these different clinical epistemologies and further explore the implications of big data and machine learning for a philosophy of clinical judgement. We argue for a pluralistic, integrative approach, and demonstrate how narrative, virtue-based clinical reasoning will remain indispensable in an era of big data and predictive analytics. © 2017 John Wiley & Sons, Ltd.

  16. Space Station Human Factors Research Review. Volume 1: EVA Research and Development

    NASA Technical Reports Server (NTRS)

    Cohen, Marc M. (Editor); Vykukal, H. C. (Editor)

    1988-01-01

    An overview is presented of extravehicular activity (EVA) research and development activities at Ames. The majority of the program was devoted to presentations by the three contractors working in parallel on the EVA System Phase A Study, focusing on Implications for Man-Systems Design. Overhead visuals are included for a mission results summary, space station EVA requirements and interface accommodations summary, human productivity study cross-task coordination, and advanced EVAS Phase A study implications for man-systems design. Articles are also included on subsea approach to work systems development and advanced EVA system design requirements.

  17. NATO Missile Defense and the European Phased Adaptive Approach: The Implications of Burden Sharing and the Underappreciated Role of the U.S. Army

    DTIC Science & Technology

    2013-10-01

    IMPLICATIONS OF BURDEN SHARING AND THE UNDERAPPRECIATED ROLE OF THE U.S. ARMY Steven J. Whitmore John R. Deni October 2013 The views expressed in this...of the Army for Man- power and Reserve Affairs. A SETM temporary duty (TDY) As- signment allowed Mr. Whitmore , an employee of the U.S. Army Aviation...contribute to the common effort as well. However, for a number of reasons, which co-au- thors Mr. Steven J. Whitmore and Dr. John R. Deni explain in terms

  18. Implications of Peer Pressure for Adolescent Nursing Research: A Concept Analysis Approach.

    PubMed

    Pittman, Alison F

    2018-01-02

    The influence of peers is widely held as a significant factor in child and adolescent development. As health care providers seek ways to improve the health of children and adolescents, peer pressure must be examined. This article analyzes peer pressure and its relationship to the health of children and adolescents. Defining attributes of peer pressure are discussed, including incomplete identity formation, the presence of a peer influence, and a need for approval. Antecedents and consequences of peer pressure are also explored. Methods of measuring peer pressure are discussed, along with implications for health care research in the pediatric population.

  19. The New Sepsis Definitions: Implications for the Basic and Translational Research Communities.

    PubMed

    Coopersmith, Craig M; Deutschman, Clifford S

    2017-03-01

    New definitions of sepsis and septic shock were published in early 2016, updating old definitions that have not been revisited since 2001. These new definitions should profoundly affect sepsis research. In addition, these papers present clinical criteria for identifying infected patients who are highly likely to have or to develop sepsis or septic shock. In contrast to previous approaches, these new clinical criteria are evidence based. In this review, two of the authors of the new definitions detail the content of the papers and explore the implications for shock and sepsis researchers.

  20. Novel insights, challenges and practical implications of DOHaD-omics research.

    PubMed

    Hodyl, Nicolette A; Muhlhausler, Beverly

    2016-02-15

    Research investigating the developmental origins of health and disease (DOHaD) has never had the technology to investigate physiology in such a data-rich capacity and at such a microlevel as it does now. A symposium at the inaugural meeting of the DOHaD Society of Australia and New Zealand outlined the advantages and challenges of using "-omics" technologies in DOHaD research. DOHaD studies with -omics approaches to generate large, rich datasets were discussed. We discuss implications for policy and practice and make recommendations to facilitate successful translation of results of future DOHaD-omics studies.

  1. Methodological issues in medical workforce analysis: implications for regional Australia.

    PubMed

    Hays, R B; Veitch, P C; Franklin, L; Crossland, L

    1998-02-01

    Medical workforce data have a profound impact on health policy formulation, but derived doctor population ratios (DPR) are often more relevant to plotting national trends than providing a detailed regional or local workforce perspective. Regional workforce data may be more useful if national approaches are augmented by local information. In developing a detailed workforce analysis for one region of Australia, the authors encountered several challenging methodological issues, including the accuracy of medical workforce databases, clarity of definition of community boundaries, interpretation of workforce definitions and the difficulty accounting for local community needs. This paper discusses the implications for regional workforce research.

  2. A Consumer-Oriented Control Framework for Performance Analysis in Hybrid Electric Vehicles

    DOE PAGES

    Shaltout, Mohamed L.; Malikopoulos, Andreas A.; Pannala, Sreekanth; ...

    2014-12-09

    Hybrid electric vehicles (HEVs) have attracted considerable attention due to their potential to reduce fuel consumption and emissions. Our objective with this paper is to enhance our understanding of the associated tradeoffs among the HEV subsystems, e.g., the engine, the motor, and the battery, and investigate the related implications for fuel consumption and battery capacity and lifetime. Addressing this problem can provide insights on how to prioritize these objectives based on consumers needs and preferences. The results of the proposed optimization approach can also be used to investigate the implications for HEV costs related to ownership and warranty.

  3. A survey of intelligent tutoring systems: Implications for complex dynamic systems

    NASA Technical Reports Server (NTRS)

    Chu, Rose W.

    1989-01-01

    An overview of the research in the field of intelligent tutorial systems (ITS) is provided. The various approaches in the design and implementation of ITS are examined and discussed in the context of problem solving in an environment of a complex dynamic system (CDS). Issues pertaining to a CDS and the nature of human problem solving especially in light of a CDS are considered. An overview of the architecture of an ITS is provided as the basis for the in-depth examination of various systems. Finally, the implications for the design and evaluation of an ITS are discussed.

  4. Introversion and extroversion: implications for depression and suicidality.

    PubMed

    Janowsky, D S

    2001-12-01

    A growing body of information suggests that core or underlying personality is a significant concomitant of depression and suicidality. Introversion (ie, low extroversion) is especially promising in its relationship to the phenomenology and outcome of depression, and may represent an underlying heritable trait of etiologic significance. Furthermore, the presence of introversion has implications for differentiating unipolar and bipolar depression. It is likely that introversion acts in concert with other core personality variables, including neuroticism and having a feeling-type personality to influence depression. Considering depression from the perspective of core personality allows for novel psychotherapeutic approaches based on targeting underlying personality variables.

  5. BULGARIA’S MULTI-VECTOR FOREIGN POLICY APPROACH TO SECURITY CHALLENGES IN EASTERN EUROPE

    DTIC Science & Technology

    2017-04-06

    withdraw from the South Stream natural gas pipeline project which could turn Bulgaria into a leading gas hub in the Balkans. Amid Ukrainian Crisis, the EU...Corporation. Micco, Pasquale De. July 2015. Changing Pipelines , Shifting Strategies: Gas in South-eastern Europe, and the Implications for Ukraine. In...catastrophe. In support of this strategic approach, this paper finds a theoretical explanation in the realist school of study and presents an analysis of the

  6. Structure and Function of Ephemeral Streams in the Arid and Semiarid Southwest: Implications for Conservation and Management

    DTIC Science & Technology

    2015-07-24

    stream flow, trade-offs were apparent between riparian plant biomass (high at wetter sites) and plant species diversity (high at dry sites with...iv) between wet and dry seasons? Technical Approach. A space-for-time substitution approach was followed in which changes across spatial water...For arthropods, pitfall traps were set during dry and wet seasons in channel, riparian and upland locations in canyon and piedmont reaches to

  7. Genetic Testing: How Genetics and Genomics Can Affect Healthcare Disparities
.

    PubMed

    Allen, Deborah

    2018-02-01

    Advances in oncology care have transformed treatment approaches as genetics and genomics analyses promote implementation of personalized medicine. Genetics and genomics research in TP53 have demonstrated that some mutations are prevalent in minority populations. This has implications on personalized treatment approaches, particularly in early disease stages. The purpose of this article is to describe oncology nurses' role in applying these findings in practice to reduce disparities observed in cancer and survivorship care.
.

  8. Brain-specific enhancers for cell-based therapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Visel, Axel; Rubenstein, John L.R.; Chen, Ying-Jiun

    Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.

  9. Comparing child protective investigation performance between law enforcement agencies and child welfare agencies.

    PubMed

    Jordan, Neil; Yampolskaya, Svetlana; Gustafson, Mara; Armstrong, Mary; McNeish, Roxann; Vargo, Amy

    2011-01-01

    This study examines the comparative effectiveness of using law enforcement agencies for child protective investigation (CPI), in contrast with the traditional approach of CPI conducted by the public child welfare agency. The analysis uses 2006-2007 data from a natural experiment conducted in Florida to show modest differences in performance and cost-efficiency between the two approaches to CPI. These findings may have implications for other states considering outsourcing CPI to law enforcement.

  10. Projecting biodiversity and wood production in future forest landscapes: 15 key modeling considerations.

    PubMed

    Felton, Adam; Ranius, Thomas; Roberge, Jean-Michel; Öhman, Karin; Lämås, Tomas; Hynynen, Jari; Juutinen, Artti; Mönkkönen, Mikko; Nilsson, Urban; Lundmark, Tomas; Nordin, Annika

    2017-07-15

    A variety of modeling approaches can be used to project the future development of forest systems, and help to assess the implications of different management alternatives for biodiversity and ecosystem services. This diversity of approaches does however present both an opportunity and an obstacle for those trying to decide which modeling technique to apply, and interpreting the management implications of model output. Furthermore, the breadth of issues relevant to addressing key questions related to forest ecology, conservation biology, silviculture, economics, requires insights stemming from a number of distinct scientific disciplines. As forest planners, conservation ecologists, ecological economists and silviculturalists, experienced with modeling trade-offs and synergies between biodiversity and wood biomass production, we identified fifteen key considerations relevant to assessing the pros and cons of alternative modeling approaches. Specifically we identified key considerations linked to study question formulation, modeling forest dynamics, forest processes, study landscapes, spatial and temporal aspects, and the key response metrics - biodiversity and wood biomass production, as well as dealing with trade-offs and uncertainties. We also provide illustrative examples from the modeling literature stemming from the key considerations assessed. We use our findings to reiterate the need for explicitly addressing and conveying the limitations and uncertainties of any modeling approach taken, and the need for interdisciplinary research efforts when addressing the conservation of biodiversity and sustainable use of environmental resources. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Genetic basis and gene therapy trials for thyroid cancer.

    PubMed

    Al-Humadi, Hussam; Zarros, Apostolos; Al-Saigh, Rafal; Liapi, Charis

    2010-01-01

    Gene therapy is regarded as one of the most promising novel therapeutic approaches for hopeless cases of thyroid cancer and those not responding to traditional treatment. In the last two decades, many studies have focused on the genetic factors behind the origin and the development of thyroid cancer, in order to investigate and shed more light on the molecular pathways implicated in different differentiated or undifferentiated types of thyroid tumors. We, herein, review the current data on the main genes that have been proven to (or thought to) be implicated in thyroid cancer etiology, and which are involved in several well-known signaling pathways (such as the mitogen-activated protein kinase and phosphatidylinositol-3-kinase/Akt pathways). Moreover, we review the results of the efforts made through multiple gene therapy trials, via several gene therapy approaches/strategies, on different thyroid carcinomas. Our review leads to the conclusion that future research efforts should seriously consider gene therapy for the treatment of thyroid cancer, and, thus, should: (a) shed more light on the molecular basis of thyroid cancer tumorigenesis, (b) focus on the development of novel gene therapy approaches that can achieve the required antitumoral efficacy with minimum normal tissue toxicity, as well as (c) perform more gene therapy clinical trials, in order to acquire more data on the efficacy of the examined approaches and to record the provoked adverse effects.

  12. Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans.

    PubMed

    Heinrichs, Markus; Domes, Gregor

    2008-01-01

    The fundamental ability to form attachment is indispensable for human social relationships. Impairments in social behaviour are associated with decreased quality of life and psychopathological states. In non-human mammals, the neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are key mediators of complex social behaviours, including attachment, social recognition and aggression. In particular, OXT reduces behavioural and neuroendocrine responses to social stress and seems both to enable animals to overcome their natural avoidance of proximity and to inhibit defensive behaviour, thereby facilitating approach behaviour. AVP has primarily been implicated in male-typical social behaviours, including aggression and pair-bond formation, and mediates anxiogenic effects. Initial studies in humans suggest behavioural, neural, and endocrine effects of both neuropeptides, similar to those found in animal studies. This review focuses on advances made to date in the effort to understand the role of OXT and AVP in human social behaviour. First, the literature on OXT and AVP and their involvement in social stress and anxiety, social cognition, social approach, and aggression is reviewed. Second, we discuss clinical implications for mental disorders that are associated with social deficits (e.g. autism spectrum disorder, borderline personality disorder). Finally, a model of the interactions of anxiety and stress, social approach behaviour, and the oxytocinergic system is presented, which integrates the novel approach of a psychobiological therapy in psychopathological states.

  13. Intersectionality and Liberal Education

    ERIC Educational Resources Information Center

    Butler, Johnella E.

    2017-01-01

    Intersectionality--an integrated approach to analyzing the complex, matrix-like interconnections among patterns of discrimination based on race, gender, and other social identities, with the goal of highlighting how resulting inequalities are experienced--has many implications for exploring the relationship between knowledge and experience and for…

  14. Integrated Circuits in the Introductory Electronics Laboratory

    ERIC Educational Resources Information Center

    English, Thomas C.; Lind, David A.

    1973-01-01

    Discusses the use of an integrated circuit operational amplifier in an introductory electronics laboratory course for undergraduate science majors. The advantages of this approach and the implications for scientific instrumentation are identified. Describes a number of experiments suitable for the undergraduate laboratory. (Author/DF)

  15. Erickson and Rogers: The Differences Do Make a Difference.

    ERIC Educational Resources Information Center

    Lopez, Frederick G.

    1987-01-01

    Extends an earlier discussion by Gunnison (1985) of the similarities between Milton Erickson and Carl Rogers by citing several important differences in their respective counseling approaches. Briefly discusses implications of these differences to the continuing evolution of counseling theory and practice. (Author)

  16. Children Prenatally Exposed to Cocaine and Crack: Implications for Schools.

    ERIC Educational Resources Information Center

    Mullin, Jeff B.

    1992-01-01

    This paper considers the major consequences of prenatal exposure to cocaine, including physiological effects and characteristics of exposed infants and then goes on to discuss the education of these children, noting various behavioral approaches and the importance of assessment. (DB)

  17. Resiliency Programming for Adult Offenders in Georgia.

    ERIC Educational Resources Information Center

    Rees, E. Frances

    2000-01-01

    Discusses resiliency programming as an alternative approach to program development for incarcerated adults, and describes a pilot project in a Georgia prison, Leadership Development, that uses the concept of resiliency to frame inmate education. Discusses implications of this model of correctional education. (SLD)

  18. Readability Approaches: Implications for Turkey

    ERIC Educational Resources Information Center

    Ulusoy, Mustafa

    2006-01-01

    Finding the right fit between students' reading ability and textbooks is very important for comprehension. Readability studies aim to analyse texts to find the right fit between students and texts. In this literature review, readability studies are classified under quantitative, qualitative and combined quantitative-qualitative readability…

  19. Tourette Syndrome: A Review and Educational Implications.

    ERIC Educational Resources Information Center

    Bauer, Anne M.; Shea, Thomas M.

    1984-01-01

    Tourette Syndrome, a condition characterized by involuntary muscular and verbal tics, is defined, its course described, incidence noted (possibly 1.6 percent of the population), etiology considered (from viewpoints of psychogenic and organic theories), treatment (primarily pharmaceutical therapy) discussed, and educational approaches examined.…

  20. A Taxonomic Approach to the Gestalt Theory of Perls

    ERIC Educational Resources Information Center

    Raming, Henry E.; Frey, David H.

    1974-01-01

    This study applied content analysis and cluster analysis to the ideas of Fritz Perls to develop a taxonomy of Gestalt processes and goals. Summaries of the typal groups or clusters were written and the implications of taxonomic research in counseling discussed. (Author)

  1. The Inquiry Approach in Dental Hygiene Education.

    ERIC Educational Resources Information Center

    Scott, Ruth Lois; And Others

    1985-01-01

    A study to assess the impact of an inquiry-oriented curriculum in a dental hygiene program is described. Two instruments, designed to measure student perception of personal and faculty inquiry and disinquiry behavior, were administered. The implications of the findings are discussed. (Author/MLW)

  2. Molecular approaches for the characterization of foodborne pathogens in poultry

    USDA-ARS?s Scientific Manuscript database

    Background: The transmission of Campylobacter spp. and baseline level of antimicrobial resistance associated with these organisms has significant implications for environmental, animal, and human health. One focus is the use of antibiotics in animal agriculture and the effects on antibiotic resistan...

  3. The Video Boom's Impact on Social Studies: Implications, Applications, and Resources.

    ERIC Educational Resources Information Center

    Considine, David M.

    1989-01-01

    Considers three approaches to using entertainment films in history and social studies classes. Provides a list of Hollywood films currently available on videotape and a list of books, articles, and journals dealing with the role of film in society. (GG)

  4. All Our Children: Handicapped and Normal.

    ERIC Educational Resources Information Center

    Johnson, Marilyn J.; Scruggs, Thomas E.

    The two part presentation presents information on specific conditions of developmental delay and suggests intervention approaches. Three causes of mental retardation (Down's syndrome, Fetal Alcohol Syndrome, and cerebral palsy) are identified and described in terms of definition, incidence, characteristics, and educational implications. Part II is…

  5. Counseling Taiwan Chinese in America: Training Issues for Counselors.

    ERIC Educational Resources Information Center

    Miller, Geri; Yang, Julia; Chen, M.

    1997-01-01

    Examines cultural influences (such as Confucianism, family, and immigration) on Taiwan Chinese in America who seek counseling. Addresses typical counseling struggles, effective counseling strategies and theoretical approaches, and training implications. Uses a case study to elaborate on the above themes. (RJM)

  6. Mental energy: Assessing the motivation dimension.

    PubMed

    Barbuto, John E

    2006-07-01

    Content-based theories of motivation may best uti lize the meta-theory of work motivation. Process-based theories may benefit most from adopting Locke and Latham's goal-setting approaches and measures. Decision-making theories should utilize the measurement approach operationalized by Ilgen et al. Sustained effort theories should utilize similar approaches to those used in numerous studies of intrinsic motivation, but the measurement of which is typically observational or attitudinal. This paper explored the implications of the four approaches to studying motivation on the newly estab ished model of mental energy. The approach taken for examining motivation informs the measurement of mental energy. Specific recommendations for each approach were developed and provided. As a result of these efforts, it will now be possible to diagnose, measure, and experimentally test for changes in human motivation, which is one of the three major components of mental energy.

  7. Approach--avoidance motivation and information processing: a cross-cultural analysis.

    PubMed

    Hamamura, Takeshi; Meijer, Zita; Heine, Steven J; Kamaya, Kengo; Hori, Izumi

    2009-04-01

    Much recent research suggests that North Americans more frequently experience approach motivations and East Asians more frequently experience avoidance motivations. The current research explores some cognitive implications of this cultural difference. North Americans should be more attentive to approach-oriented information, whereas East Asians should be more attentive to avoidance-oriented information. Three studies confirmed this hypothesis. When asked to recall information framed in either approach or avoidance terms, a predicted interaction between culture and information frame was observed (Study 1 and 2). Moreover, analyses of consumer book reviews found that among reviews that were rated as helpful, approach-focused content was more prevalent in American reviews compared to Japanese reviews, in which avoidance-focused content was more prevalent (Study 3). Findings from the current research add to the growing literature of cross-cultural research on approach-avoidance motivations.

  8. Students’ Achievement Goals, Learning-Related Emotions and Academic Achievement

    PubMed Central

    Lüftenegger, Marko; Klug, Julia; Harrer, Katharina; Langer, Marie; Spiel, Christiane; Schober, Barbara

    2016-01-01

    In the present research, the recently proposed 3 × 2 model of achievement goals is tested and associations with achievement emotions and their joint influence on academic achievement are investigated. The study was conducted with 388 students using the 3 × 2 Achievement Goal Questionnaire including the six proposed goal constructs (task-approach, task-avoidance, self-approach, self-avoidance, other-approach, other-avoidance) and the enjoyment and boredom scales from the Achievement Emotion Questionnaire. Exam grades were used as an indicator of academic achievement. Findings from CFAs provided strong support for the proposed structure of the 3 × 2 achievement goal model. Self-based goals, other-based goals and task-approach goals predicted enjoyment. Task-approach goals negatively predicted boredom. Task-approach and other-approach predicted achievement. The indirect effects of achievement goals through emotion variables on achievement were assessed using bias-corrected bootstrapping. No mediation effects were found. Implications for educational practice are discussed. PMID:27199836

  9. Intensified Sampling in Response to a Salmonella Heidelberg Outbreak Associated with Multiple Establishments Within a Single Poultry Corporation

    PubMed Central

    Defibaugh-Chavez, Stephanie; Douris, Aphrodite; Vetter, Danah; Atkinson, Richard; Kissler, Bonnie; Khroustalev, Allison; Robertson, Kis; Sharma, Yudhbir; Becker, Karen; Dessai, Uday; Antoine, Nisha; Allen, Latasha; Holt, Kristin; Gieraltowski, Laura; Wise, Matthew; Schwensohn, Colin

    2018-01-01

    Abstract On June 28, 2013, the Food Safety and Inspection Service (FSIS) was notified by the Centers for Disease Control and Prevention (CDC) of an investigation of a multistate cluster of illnesses of Salmonella enterica serovar Heidelberg. Since case-patients in the cluster reported consumption of a variety of chicken products, FSIS used a simple likelihood-based approach using traceback information to focus on intensified sampling efforts. This article describes the multiphased product sampling approach taken by FSIS when epidemiologic evidence implicated chicken products from multiple establishments operating under one corporation. The objectives of sampling were to (1) assess process control of chicken slaughter and further processing and (2) determine whether outbreak strains were present in products from these implicated establishments. As part of the sample collection process, data collected by FSIS personnel to characterize product included category (whole chicken and type of chicken parts), brand, organic or conventional product, injection with salt solutions or flavorings, and whether product was skinless or skin-on. From the period September 9, 2013, through October 31, 2014, 3164 samples were taken as part of this effort. Salmonella percent positive declined from 19.7% to 5.3% during this timeframe as a result of regulatory and company efforts. The results of intensified sampling for this outbreak investigation informed an FSIS regulatory response and corrective actions taken by the implicated establishments. The company noted that a multihurdle approach to reduce Salmonella in products was taken, including on-farm efforts such as environmental testing, depopulation of affected flocks, disinfection of affected houses, vaccination, and use of various interventions within the establishments over the course of several months. PMID:29638165

  10. Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans.

    PubMed

    Alan, Jamie K; Struckhoff, Eric C; Lundquist, Erik A

    2013-01-01

    Rho GTPases are key regulators of cellular protrusion and are involved in many developmental events including axon guidance during nervous system development. Rho GTPase pathways display functional redundancy in developmental events, including axon guidance. Therefore, their roles can often be masked when using simple loss-of-function genetic approaches. As a complement to loss-of-function genetics, we constructed a constitutively activated CDC-42(G12V) expressed in C. elegans neurons. CDC-42(G12V) drove the formation of ectopic lamellipodial and filopodial protrusions in the PDE neurons, which resembled protrusions normally found on migrating growth cones of axons. We then used a candidate gene approach to identify molecules that mediate CDC-42(G12V)-induced ectopic protrusions by determining if loss of function of the genes could suppress CDC-42(G12V). Using this approach, we identified 3 cytoskeletal pathways previously implicated in axon guidance, the Arp2/3 complex, UNC-115/abLIM, and UNC-43/Ena. We also identified the Nck-interacting kinase MIG-15/NIK and p21-activated kinases (PAKs), also implicated in axon guidance. Finally, PI3K signaling was required, specifically the Rictor/mTORC2 branch but not the mTORC1 branch that has been implicated in other aspects of PI3K signaling including stress and aging. Our results indicate that multiple pathways can mediate CDC-42-induced neuronal protrusions that might be relevant to growth cone protrusions during axon pathfinding. Each of these pathways involves Rac GTPases, which might serve to integrate the pathways and coordinate the multiple CDC-42 pathways. These pathways might be relevant to developmental events such as axon pathfinding as well as disease states such as metastatic melanoma.

  11. Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans

    PubMed Central

    Alan, Jamie K; Struckhoff, Eric C; Lundquist, Erik A

    2013-01-01

    Rho GTPases are key regulators of cellular protrusion and are involved in many developmental events including axon guidance during nervous system development. Rho GTPase pathways display functional redundancy in developmental events, including axon guidance. Therefore, their roles can often be masked when using simple loss-of-function genetic approaches. As a complement to loss-of-function genetics, we constructed a constitutively activated CDC-42(G12V) expressed in C. elegans neurons. CDC-42(G12V) drove the formation of ectopic lamellipodial and filopodial protrusions in the PDE neurons, which resembled protrusions normally found on migrating growth cones of axons. We then used a candidate gene approach to identify molecules that mediate CDC-42(G12V)-induced ectopic protrusions by determining if loss of function of the genes could suppress CDC-42(G12V). Using this approach, we identified 3 cytoskeletal pathways previously implicated in axon guidance, the Arp2/3 complex, UNC-115/abLIM, and UNC-43/Ena. We also identified the Nck-interacting kinase MIG-15/NIK and p21-activated kinases (PAKs), also implicated in axon guidance. Finally, PI3K signaling was required, specifically the Rictor/mTORC2 branch but not the mTORC1 branch that has been implicated in other aspects of PI3K signaling including stress and aging. Our results indicate that multiple pathways can mediate CDC-42-induced neuronal protrusions that might be relevant to growth cone protrusions during axon pathfinding. Each of these pathways involves Rac GTPases, which might serve to integrate the pathways and coordinate the multiple CDC-42 pathways. These pathways might be relevant to developmental events such as axon pathfinding as well as disease states such as metastatic melanoma. PMID:24149939

  12. Cumulative emission budgets and their implications: the case for SAFE carbon

    NASA Astrophysics Data System (ADS)

    Allen, Myles; Bowerman, Niel; Frame, David; Mason, Charles

    2010-05-01

    The risk of dangerous long-term climate change due to anthropogenic carbon dioxide emissions is predominantly determined by cumulative emissions over all time, not the rate of emission in any given year or commitment period. This has profound implications for climate mitigation policy: emission targets for specific years such as 2020 or 2050 provide no guarantee of meeting any overall cumulative emission budget. By focusing attention on short-term measures to reduce the flow of emissions, they may even exacerbate the overall long-term stock. Here we consider how climate policies might be designed explicitly to limit cumulative emissions to, for example, one trillion tonnes of carbon, a figure that has been estimated to give a most likely warming of two degrees above pre-industrial, with a likely range of 1.6-2.6 degrees. Three approaches are considered: tradable emission permits with the possibility of indefinite emission banking, carbon taxes explicitly linked to cumulative emissions and mandatory carbon sequestration. Framing mitigation policy around cumulative targets alleviates the apparent tension between climate protection and short-term consumption that bedevils any attempt to forge global agreement. We argue that the simplest and hence potentially the most effective approach might be a mandatory requirement on the fossil fuel industry to ensure that a steadily increasing fraction of fossil carbon extracted from the ground is artificially removed from the active carbon cycle through some form of sequestration. We define Sequestered Adequate Fraction of Extracted (SAFE) carbon as a source in which this sequestered fraction is anchored to cumulative emissions, increasing smoothly to reach 100% before we release the trillionth tonne. While adopting the use of SAFE carbon would increase the cost of fossil energy much as a system of emission permits or carbon taxes would, it could do so with much less explicit government intervention. We contrast this proposal with, for example, the WBGU budget approach which also recognises the importance of cumulative emissions, noting their different implications for global equity and development considerations. The implications of cumulative emissions for the issue of historical responsibility for adaptation costs will also be discussed.

  13. Forms of Knowledge and Curriculum Coherence

    ERIC Educational Resources Information Center

    Muller, Johan

    2009-01-01

    This paper examines what is entailed by taking a socio-epistemic or "knowledge-based" approach to considerations of curriculum and qualifications. The paper begins by examining the roots of disciplinary difference in the medieval universities and their treatment in contemporary scholarly work; discusses implications for curriculum and…

  14. The New Learning Market.

    ERIC Educational Resources Information Center

    Mager, Caroline; Robinson, Peter; Fletcher, Mick; Stanton, Geoff; Perry, Adrian; Westwood, Andy

    This document contains seven papers examining the implications of proposed major reforms to the United Kingdom's post-16 sector. "The New Learning Market--Overview" (Caroline Mager) argues for balancing market-driven and planning-driven approaches to planning post-16 education. "Education and Training as a Learning Market"…

  15. The Multivariate Structure of Communication Avoidance.

    ERIC Educational Resources Information Center

    Bell, Robert A.

    1986-01-01

    Clarifies the nature of communication avoidance through a structural analysis grounded in facet theory. Presents evidence for a duplex model of avoidance in which theoretical distinctions among modalities of approach-avoidance and context proved empirically relevant. Discusses implications of these findings for the explication, treatment, and…

  16. Expanding Models of Lake Trophic State to Predict Cyanobacteria in Lakes: A Data Mining Approach

    EPA Science Inventory

    Background/Question/Methods: Cyanobacteria are a primary taxonomic group associated with harmful algal blooms in lakes. Understanding the drivers of cyanobacteria presence has important implications for lake management and for the protection of human and ecosystem health. Chloro...

  17. Multicultural Issues in Counseling: New Approaches to Diversity.

    ERIC Educational Resources Information Center

    Lee, Courtland C., Ed.; Richardson, Bernard L., Ed.

    This book was written to provide counseling and human development professionals with specific guidelines for becoming more culturally responsive. It looks at the evolution of multicultural counseling, addresses ideas and concepts for culturally responsive counseling interventions, and examines the implications of cultural diversity for future…

  18. Designing for the Disabled.

    ERIC Educational Resources Information Center

    Goldsmith, Selwyn

    Implications of the merits of normality and independence for the disabled, and their relevance to architectural design criteria are discussed. The introduction reflects the philosophical approach to the design and construction of public buildings and housing. Nine principle sections provide data and recommendations on the following topics:…

  19. Policy Issues in Interactive Cable Television.

    ERIC Educational Resources Information Center

    Kay, Peg

    1978-01-01

    Raises several policy issues concerning interactive cable television, including the role of government and the regulation powers, and the implications of telecommunication/social service system concerning privacy and confidentiality, approaches to electronic opinion polling, and the potential widening of the information gap between rich and poor.…

  20. An Online Approach to Teaching International Outsourcing in Technical Communication Classes

    ERIC Educational Resources Information Center

    St. Amant, Kirk

    2005-01-01

    The growth of international online access has given rise to a new production method--international outsourcing--that has important implications for technical communication practices. Successful interactions within international outsourcing require individuals to understand how cultural factors could affect online interactions. Today's technical…

  1. The Failing Campus Infrastructure: Is It Too Late?

    ERIC Educational Resources Information Center

    Medlin, E. Lander

    2000-01-01

    Discusses the extent of damage being caused to colleges and universities from accumulated deferred maintenance (ADM) and why it is happening. Public policy implications are discussed along with highlights from case studies of institutions that have used practical approaches to retire their ADMs. (GR)

  2. New perspectives in forest management: background, science issues, and research agenda.

    Treesearch

    David J. Brooks; Gordon E. Grant

    1992-01-01

    Scientific, management, and social factors that have contributed to changes in United States forest management are examined. Principles underlying new approaches are developed and implications are considered at various spatial and temporal scales. A general framework for a research program is outlined.

  3. Future travel demand and its implications for transportation infrastructure investments in the Texas Triangle.

    DOT National Transportation Integrated Search

    2009-03-01

    This study takes a megaregion approach to project future travel demand and choice of transport : modes in the Texas Triangle, which is encompassed by four major metropolitan areas, Dallas-Fort : Worth, Houston, San Antonio, and Austin. The model was ...

  4. Humanistic Intentionality in Clinical Collaboration

    ERIC Educational Resources Information Center

    Gold, Joshua

    2016-01-01

    This conceptual paper introduces a clinical collaboration model for counselors founded in the principles of humanistic counseling and wellness. The article offers applications for client life self-assessment and the discovery of personally relevant social resources. Finally, implications of this approach for graduate training, clinical service and…

  5. Intercultural Counselling and Assessment: Global Perspectives.

    ERIC Educational Resources Information Center

    Samuda, Ronald J., Ed.; Wolfgang, Aaron, Ed.

    This book concerning the need for more appropriate approaches to intercultural counseling in counselor training includes these articles: (1) "Comparative Immigration Patterns in the U.S., Australia and Canada: Social and Educational Implications" (R. J. Samuda); (2) "Theories of Counselling: A Comparative Analysis" (C. E.…

  6. Note: The Numbering of Postgraduate Research.

    ERIC Educational Resources Information Center

    Wafford, Geoffrey

    1984-01-01

    Implications of the trend toward funding only graduate research projects that have a high likelihood of completion are discussed, including allocation of funds according to institutions' completion rates, deemphasis on research quality and students' personal development, and overemphasis on producing graduates. A more balanced approach to research…

  7. Treatment of Childhood Depression: The State of the Art.

    ERIC Educational Resources Information Center

    Clarizio, Harvey F.

    1986-01-01

    This article reviews various aspects of seven approaches to the treatment of childhood depression--psychoanalytic, behavioral, cognitive, familial, rational-emotive, multimodal, and drug interventions. Implications for practitioners are considered in terms of target selection, choice of treatment methods, rational evaluation based on developmental…

  8. The Interaction of Mantle Plumes with Surface Thermal and Chemical Boundary Layers: Applications to Hotspots on Venus

    NASA Technical Reports Server (NTRS)

    Smrekar, S.; Parmentier, E.

    1994-01-01

    Describes the characteristics of possible hotspots on Venus, the approach used to simulate mantle upwelling, model results, and presents the implications for the properties of plumes and the lithosphere, hotspot evolution, and resurfacing on Venus.

  9. USING ABIOTIC INDICATORS OF REFERENCE CONDITION AND BIOTIC INDICATORS OF CONDITION TO ASSESS GREAT RIVER ECOSYSTEMS

    EPA Science Inventory

    This presentation outlines the approach and preliminary assessment results for EMAP-GRE. The use of biological indicators and reference conditions for river assessments has implications for scientists, river managers, and state and tribal natural resource regulators.

  10. Evaluation of Career Development Programs from an Action Perspective.

    ERIC Educational Resources Information Center

    Young, Richard A.; Valach, Ladislav

    1994-01-01

    Presents action-theoretical approach to evaluation of career development programs based on constructionist epistemology. Propositions from action-theoretical perspective center around career and action as related, interpretative constructs. Propositions give rise to implications for evaluation of career programs that address ongoing nature of…

  11. Parent Empowerment and Teacher Professionalism: Teachers' Perspective

    ERIC Educational Resources Information Center

    Addi-Raccah, Audrey; Arviv-Elyashiv, Rinate

    2008-01-01

    School decentralization, which has reshaped power relations in the educational system, has empowered teachers and parents. Taking Abbott's approach to professions, the authors examine teachers' perceptions of the implications of parents' empowerment for teacher--parent relations. In-depth interviews with homeroom teachers in affluent urban…

  12. Technological Revolutions: Some Implications for the Social Studies

    ERIC Educational Resources Information Center

    Kane, Paul W.

    1975-01-01

    The advantages of a social studies program, centered on the various technological revolutions -- human, agricultural, urban, industrial, and humanizing -- are a multi-disciplinary approach, the use of inquiry skills, wide coverage of history and nations through a framework of concepts, and discussion of ethnocentrism. (JH)

  13. Different Argentine Rural Extensionists' Mindsets and Their Practical Implications

    ERIC Educational Resources Information Center

    Landini, Fernando

    2015-01-01

    Purpose: This paper reflects upon the practice of Argentine rural extensionists working in the extension public system through the process of identifying different rural extensionists' types of mindsets and comparing them with transfer of technology extension approach, dialogical processes of horizontal knowledge exchange, participatory…

  14. Conceptualizing and Assessing Self-Enhancement Bias: A Componential Approach

    PubMed Central

    Kwan, Virginia S. Y.; Kuang, Lu Lu; John, Oliver P.; Robins, Richard W.

    2014-01-01

    Four studies implemented a componential approach to assessing self-enhancement and contrasted this approach with 2 earlier ones: social comparison (comparing self-ratings with ratings of others) and self-insight (comparing self-ratings with ratings by others). In Study 1, the authors varied the traits being rated to identify conditions that lead to more or less similarity between approaches. In Study 2, the authors examined the effects of acquaintance on the conditions identified in Study 1. In Study 3, the authors showed that using rankings renders the self-insight approach equivalent to the component-based approach but also has limitations in assessing self-enhancement. In Study 4, the authors compared the social-comparison and the component-based approaches in terms of their psychological implications; the relation between self-enhancement and adjustment depended on the self-enhancement approach used, and the positive-adjustment correlates of the social-comparison approach disappeared when the confounding influence of the target effect was controlled. PMID:18505318

  15. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

    PubMed

    Manning, Alisa K; Hivert, Marie-France; Scott, Robert A; Grimsby, Jonna L; Bouatia-Naji, Nabila; Chen, Han; Rybin, Denis; Liu, Ching-Ti; Bielak, Lawrence F; Prokopenko, Inga; Amin, Najaf; Barnes, Daniel; Cadby, Gemma; Hottenga, Jouke-Jan; Ingelsson, Erik; Jackson, Anne U; Johnson, Toby; Kanoni, Stavroula; Ladenvall, Claes; Lagou, Vasiliki; Lahti, Jari; Lecoeur, Cecile; Liu, Yongmei; Martinez-Larrad, Maria Teresa; Montasser, May E; Navarro, Pau; Perry, John R B; Rasmussen-Torvik, Laura J; Salo, Perttu; Sattar, Naveed; Shungin, Dmitry; Strawbridge, Rona J; Tanaka, Toshiko; van Duijn, Cornelia M; An, Ping; de Andrade, Mariza; Andrews, Jeanette S; Aspelund, Thor; Atalay, Mustafa; Aulchenko, Yurii; Balkau, Beverley; Bandinelli, Stefania; Beckmann, Jacques S; Beilby, John P; Bellis, Claire; Bergman, Richard N; Blangero, John; Boban, Mladen; Boehnke, Michael; Boerwinkle, Eric; Bonnycastle, Lori L; Boomsma, Dorret I; Borecki, Ingrid B; Böttcher, Yvonne; Bouchard, Claude; Brunner, Eric; Budimir, Danijela; Campbell, Harry; Carlson, Olga; Chines, Peter S; Clarke, Robert; Collins, Francis S; Corbatón-Anchuelo, Arturo; Couper, David; de Faire, Ulf; Dedoussis, George V; Deloukas, Panos; Dimitriou, Maria; Egan, Josephine M; Eiriksdottir, Gudny; Erdos, Michael R; Eriksson, Johan G; Eury, Elodie; Ferrucci, Luigi; Ford, Ian; Forouhi, Nita G; Fox, Caroline S; Franzosi, Maria Grazia; Franks, Paul W; Frayling, Timothy M; Froguel, Philippe; Galan, Pilar; de Geus, Eco; Gigante, Bruna; Glazer, Nicole L; Goel, Anuj; Groop, Leif; Gudnason, Vilmundur; Hallmans, Göran; Hamsten, Anders; Hansson, Ola; Harris, Tamara B; Hayward, Caroline; Heath, Simon; Hercberg, Serge; Hicks, Andrew A; Hingorani, Aroon; Hofman, Albert; Hui, Jennie; Hung, Joseph; Jarvelin, Marjo-Riitta; Jhun, Min A; Johnson, Paul C D; Jukema, J Wouter; Jula, Antti; Kao, W H; Kaprio, Jaakko; Kardia, Sharon L R; Keinanen-Kiukaanniemi, Sirkka; Kivimaki, Mika; Kolcic, Ivana; Kovacs, Peter; Kumari, Meena; Kuusisto, Johanna; Kyvik, Kirsten Ohm; Laakso, Markku; Lakka, Timo; Lannfelt, Lars; Lathrop, G Mark; Launer, Lenore J; Leander, Karin; Li, Guo; Lind, Lars; Lindstrom, Jaana; Lobbens, Stéphane; Loos, Ruth J F; Luan, Jian'an; Lyssenko, Valeriya; Mägi, Reedik; Magnusson, Patrik K E; Marmot, Michael; Meneton, Pierre; Mohlke, Karen L; Mooser, Vincent; Morken, Mario A; Miljkovic, Iva; Narisu, Narisu; O'Connell, Jeff; Ong, Ken K; Oostra, Ben A; Palmer, Lyle J; Palotie, Aarno; Pankow, James S; Peden, John F; Pedersen, Nancy L; Pehlic, Marina; Peltonen, Leena; Penninx, Brenda; Pericic, Marijana; Perola, Markus; Perusse, Louis; Peyser, Patricia A; Polasek, Ozren; Pramstaller, Peter P; Province, Michael A; Räikkönen, Katri; Rauramaa, Rainer; Rehnberg, Emil; Rice, Ken; Rotter, Jerome I; Rudan, Igor; Ruokonen, Aimo; Saaristo, Timo; Sabater-Lleal, Maria; Salomaa, Veikko; Savage, David B; Saxena, Richa; Schwarz, Peter; Seedorf, Udo; Sennblad, Bengt; Serrano-Rios, Manuel; Shuldiner, Alan R; Sijbrands, Eric J G; Siscovick, David S; Smit, Johannes H; Small, Kerrin S; Smith, Nicholas L; Smith, Albert Vernon; Stančáková, Alena; Stirrups, Kathleen; Stumvoll, Michael; Sun, Yan V; Swift, Amy J; Tönjes, Anke; Tuomilehto, Jaakko; Trompet, Stella; Uitterlinden, Andre G; Uusitupa, Matti; Vikström, Max; Vitart, Veronique; Vohl, Marie-Claude; Voight, Benjamin F; Vollenweider, Peter; Waeber, Gerard; Waterworth, Dawn M; Watkins, Hugh; Wheeler, Eleanor; Widen, Elisabeth; Wild, Sarah H; Willems, Sara M; Willemsen, Gonneke; Wilson, James F; Witteman, Jacqueline C M; Wright, Alan F; Yaghootkar, Hanieh; Zelenika, Diana; Zemunik, Tatijana; Zgaga, Lina; Wareham, Nicholas J; McCarthy, Mark I; Barroso, Ines; Watanabe, Richard M; Florez, Jose C; Dupuis, Josée; Meigs, James B; Langenberg, Claudia

    2012-05-13

    Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individuals. Risk variants were associated with higher triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci in insulin resistance pathways. The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology.

  16. Exposing the Backstage: Critical Reflections on a Longitudinal Qualitative Study of Residents’ Care Networks in Assisted Living

    PubMed Central

    Kemp, Candace L.; Ball, Mary M.; Morgan, Jennifer Craft; Doyle, Patrick J.; Burgess, Elisabeth O.; Dillard, Joy A.; Barmon, Christina E.; Fitzroy, Andrea F.; Helmly, Victoria E.; Avent, Elizabeth S.; Perkins, Molly M.

    2018-01-01

    In this article, we analyze the research experiences associated with a longitudinal qualitative study of residents’ care networks in assisted living. Using data from researcher meetings, field notes, and memos, we critically examine our design and decision making and accompanying methodological implications. We focus on one complete wave of data collection involving 28 residents and 114 care network members in four diverse settings followed for 2 years. We identify study features that make our research innovative, but that also represent significant challenges. They include the focus and topic; settings and participants; scope and design complexity; nature, modes, frequency, and duration of data collection; and analytic approach. Each feature has methodological implications, including benefits and challenges pertaining to recruitment, retention, data collection, quality, and management, research team work, researcher roles, ethics, and dissemination. Our analysis demonstrates the value of our approach and of reflecting on and sharing methodological processes for cumulative knowledge building. PMID:27651072

  17. Creating value in health care through big data: opportunities and policy implications.

    PubMed

    Roski, Joachim; Bo-Linn, George W; Andrews, Timothy A

    2014-07-01

    Big data has the potential to create significant value in health care by improving outcomes while lowering costs. Big data's defining features include the ability to handle massive data volume and variety at high velocity. New, flexible, and easily expandable information technology (IT) infrastructure, including so-called data lakes and cloud data storage and management solutions, make big-data analytics possible. However, most health IT systems still rely on data warehouse structures. Without the right IT infrastructure, analytic tools, visualization approaches, work flows, and interfaces, the insights provided by big data are likely to be limited. Big data's success in creating value in the health care sector may require changes in current polices to balance the potential societal benefits of big-data approaches and the protection of patients' confidentiality. Other policy implications of using big data are that many current practices and policies related to data use, access, sharing, privacy, and stewardship need to be revised. Project HOPE—The People-to-People Health Foundation, Inc.

  18. Pay-to-participate funding schemes in human cell and tissue clinical studies.

    PubMed

    Sipp, Douglas

    2012-11-01

    Funding support for clinical research is traditionally obtained from any of several sources, including government agencies, industry, not-for-profit foundations, philanthropies and charitable and advocacy organizations. In recent history, there have also been a limited number of cases in which clinical research programs were established in which funding was provided directly by patients in turn for the ability to participate as nonrandomized subjects. This approach to clinical research funding, which I refer to here as the 'pay-to-participate' model, has been both criticized and rationalized on ethical grounds, with reference to its implications for issues, including equipoise, therapeutic misconception, justice, autonomy and risk-benefit balance. Discussion of the scientific implications of this funding scheme, however, has been more limited. I will briefly review the history of the pay-to-participate model in the context of experimental cell and tissue treatments to date and highlight the many ethical and, particularly, scientific challenges that unavoidably confound this approach to the funding and conduct of clinical research.

  19. Implications for research and practice of the biographic approach for storytelling.

    PubMed

    Ewens, Beverley; Hendricks, Joyce; Sundin, Deb

    2017-01-23

    Background Intensive care unit survivors face many physical and psychological difficulties during their recovery following discharge from hospital. These difficulties can significantly affect their quality of life. Healthcare providers and survivors' families often do not understand what recovery means in this population, which may affect the support provided. Aim To consider the potential of the biographical method in helping to create stories that illustrate recovery in intensive care survivors and other populations. Discussion This paper identifies how the biographical approach has provided survivors with a way to uncover the hidden parts of their lives through diaries and interviews, and reveal the hidden stories of intensive care survivorship and recovery. Conclusion The application of the biographical method enabled stories to be created that identified the disruption survivors encounter as they struggle to appear recovered. Implications for practice The biographical method can illuminate experiences uncaptured by other methods. This insight into recovery journeys can help healthcare practitioners and family members to understand and recognise the need for support during recovery.

  20. Quality improvement in physiotherapy services.

    PubMed

    Boak, George; Sephton, Ruth; Hough, Elaine; Ten Hove, Ruth

    2017-06-12

    Purpose The purpose of this paper is to evaluate a process change in physiotherapy services and to explore factors that may have influenced the outcomes. Design/methodology/approach This is a multiple case study and information was gathered from eight physiotherapy teams over 24 months. Findings The process change was successfully implemented in six teams. It had a clear, positive effect on service quality provided to patients in three teams. Whilst quality also improved in three other teams, other issues make changes difficult to assess. Factors that enabled process change to be effective are suggested. Research limitations/implications The findings are based on results achieved by only eight English teams. Practical implications This process change may be appropriate for other teams providing therapy services if attention is paid to potential enabling factors, and a learning approach is adopted to designing and introducing the change. Originality/value To the best of the authors' knowledge, no other longitudinal process change study in therapy services has been published.

  1. Exposing the Backstage: Critical Reflections on a Longitudinal Qualitative Study of Residents' Care Networks in Assisted Living.

    PubMed

    Kemp, Candace L; Ball, Mary M; Morgan, Jennifer Craft; Doyle, Patrick J; Burgess, Elisabeth O; Dillard, Joy A; Barmon, Christina E; Fitzroy, Andrea F; Helmly, Victoria E; Avent, Elizabeth S; Perkins, Molly M

    2017-07-01

    In this article, we analyze the research experiences associated with a longitudinal qualitative study of residents' care networks in assisted living. Using data from researcher meetings, field notes, and memos, we critically examine our design and decision making and accompanying methodological implications. We focus on one complete wave of data collection involving 28 residents and 114 care network members in four diverse settings followed for 2 years. We identify study features that make our research innovative, but that also represent significant challenges. They include the focus and topic; settings and participants; scope and design complexity; nature, modes, frequency, and duration of data collection; and analytic approach. Each feature has methodological implications, including benefits and challenges pertaining to recruitment, retention, data collection, quality, and management, research team work, researcher roles, ethics, and dissemination. Our analysis demonstrates the value of our approach and of reflecting on and sharing methodological processes for cumulative knowledge building.

  2. Profiles of Adolescent Religiousness using Latent Profile Analysis: Implications for Psychopathology

    PubMed Central

    Longo, Gregory S.; Bray, Bethany; Kim-Spoon, Jungmeen

    2017-01-01

    Prior research has documented robust associations between adolescent religiousness/spirituality (R/S) and psychopathology outcomes including externalizing and internalizing symptomatology, yet no previous studies have examined these associations with adolescent R/S profiles using a person-centered approach. We examined if there are identifiable subgroups characterized by unique multidimensional patterns of R/S experiences and how these experiences may be related to externalizing and internalizing symptomatology. The sample consisted of 220 Appalachian adolescents between 12 and 18 years old who were primarily White and primarily Christian. Latent profile analysis revealed three profiles of adolescent R/S; high religiousness (28.4%), introjectors (47.6%), and low religiousness (24.0%). These profiles were differentially related to internalizing and externalizing symptomatology such that the high religiousness group was significantly lower than the introjectors with respect to internalizing and externalizing symptomatology and lower than the low religiousness group in externalizing symptomatology. Implications and suggestions for future research using person-centered approaches to better understand differential developmental trajectories of religious development are provided. PMID:28220955

  3. Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes.

    PubMed

    Rafehi, Haloom; Kaspi, Antony; Ziemann, Mark; Okabe, Jun; Karagiannis, Tom C; El-Osta, Assam

    2017-01-01

    Given the skyrocketing costs to develop new drugs, repositioning of approved drugs, such as histone deacetylase (HDAC) inhibitors, may be a promising strategy to develop novel therapies. However, a gap exists in the understanding and advancement of these agents to meaningful translation for which new indications may emerge. To address this, we performed systems-level analyses of 33 independent HDAC inhibitor microarray studies. Based on network analysis, we identified enrichment for pathways implicated in metabolic syndrome and diabetes (insulin receptor signaling, lipid metabolism, immunity and trafficking). Integration with ENCODE ChIP-seq datasets identified suppression of EP300 target genes implicated in diabetes. Experimental validation indicates reversal of diabetes-associated EP300 target genes in primary vascular endothelial cells derived from a diabetic individual following inhibition of HDACs (by SAHA), EP300, or EP300 knockdown. Our computational systems biology approach provides an adaptable framework for the prediction of novel therapeutics for existing disease.

  4. Prediction of child performance on a parent-child behavioral approach test with animal phobic children.

    PubMed

    Ollendick, Thomas H; Lewis, Krystal M; Cowart, Maria J W; Davis, Thompson

    2012-07-01

    A host of factors including genetic influences, temperament characteristics, learning experiences, information processing biases, parental psychopathology, and specific parenting practices have been hypothesized to contribute to the development and expression of children's phobias. In the present study, the authors focused on parental psychopathology (phobic anxiety) and parenting behaviors (warmth, involvement) in the prediction of child performance on a behavioral approach test (BAT). All children (n = 44) experienced a phobia of animals and were clinic referred. The youth completed two BATs: the first alone and the second one with a parent present. Overall, performance was greater on the parent-present BAT (58% of steps completed) than on the child-alone BAT (38% of steps completed), although considerable variability was present. Performance on the parent-present BAT was associated with parental warmth and involvement but not parental phobic anxiety. Implications of these findings were discussed, and their implications for the use of behavioral analogues tests were explored.

  5. State Authenticity as Fit to Environment: The Implications of Social Identity for Fit, Authenticity, and Self-Segregation.

    PubMed

    Schmader, Toni; Sedikides, Constantine

    2017-10-01

    People seek out situations that "fit," but the concept of fit is not well understood. We introduce State Authenticity as Fit to the Environment (SAFE), a conceptual framework for understanding how social identities motivate the situations that people approach or avoid. Drawing from but expanding the authenticity literature, we first outline three types of person-environment fit: self-concept fit, goal fit, and social fit. Each type of fit, we argue, facilitates cognitive fluency, motivational fluency, and social fluency that promote state authenticity and drive approach or avoidance behaviors. Using this model, we assert that contexts subtly signal social identities in ways that implicate each type of fit, eliciting state authenticity for advantaged groups but state inauthenticity for disadvantaged groups. Given that people strive to be authentic, these processes cascade down to self-segregation among social groups, reinforcing social inequalities. We conclude by mapping out directions for research on relevant mechanisms and boundary conditions.

  6. How frontline staff manage paperwork in group homes for people with intellectual disability: Implications for practice.

    PubMed

    Quilliam, Claire; Bigby, Christine; Douglas, Jacinta

    2018-05-08

    Paperwork is a key tool that transforms organizational intentions into actions in group homes, although prescriptive procedures may limit how frontline staff use it in practice. The aim of this study was to explore how frontline staff use paperwork in group homes for people with intellectual disability and identify practice implications. Constructivist grounded theory methodology guided the research. Data collection included semi-structured interviews and participant observations. Coding, comparison and sorting methods were adopted to analyse how staff used paperwork. Staff followed organizational paperwork rules when they aligned with their resident-focused approach to work. When they perceived rules to misalign with this approach, they managed paperwork by adjusting the time and place of completion, managing content, creating alternative tools and refusing completion. Staff purposefully managed paperwork rather than simply following procedures. Disability service organizations could develop flexible paperwork procedures and include frontline perspectives in paperwork development. © 2018 John Wiley & Sons Ltd.

  7. Policy and organizational implications of gender imbalance in the NHS.

    PubMed

    Miller, Karen

    2007-01-01

    The purpose of the paper is to examine the policy and organizational implications of gender imbalance in management, which research suggests exists in the NHS. The research in this paper involved a qualitative approach with an analysis of elite interviews conducted with a non-random sample of officials involved in health policy and interviews with a random sample of senior managers in NHS Scotland. The research formed part of a larger study, which explored the enablers and inhibitors to female career progression in various Scottish sectors. The paper finds that gender imbalance in management exists in the NHS. This is manifested in a masculine organizational context, leadership and policy decision-making process, which have implications for female career advancement opportunities and subsequently access to macro policy decisions. The paper involved a sample (30 percent) of senior managers and examined policy processes in NHS Scotland. To improve the external validity of the findings further research should be conducted in NHS organizations in England and Wales. The findings in the paper suggest that gender imbalance in management and a masculine organizational context and leadership style within the NHS create a less than conducive environment for female employees. This has practical implications in terms of levels of part-time employment, career progression and attrition rates. The paper adds to the debate of gender and organizational studies by examining the health sector, which has high levels of female employment but low levels of female representation at senior management levels. The paper therefore adds to an often-neglected area of study, women in leadership and senior managerial positions. The paper is original in its approach by examining the micro and meso organizational dimensions which impact on women's ability to influence macro health policy.

  8. Exploring team working and shared leadership in multi-disciplinary cancer care.

    PubMed

    Willcocks, Stephen George

    2018-02-05

    Purpose The purpose of this paper is to explore the relevance of shared leadership to multi-disciplinary cancer care. It examines the policy background and applies concepts from shared leadership to this context. It includes discussion of the implications and recommendations. Design/methodology/approach This is a conceptual paper examining policy documents and secondary literature on the topic. While it focuses on the UK National Health Services, it is also relevant to other countries given they follow a broadly similar path with regard to multi-disciplinary working. Findings The paper suggests that shared leadership is a possible way forward for multi-disciplinary cancer care, particularly as policy developments are supportive of this. It shows that a shared perspective is likely to be beneficial to the further development of multi-disciplinary working. Research limitations/implications Adopting shared leadership needs to be explored further using appropriate empirical research. Practical implications The paper offers comments on the implications of introducing shared leadership and makes recommendations including being aware of the barriers to its implementation. Originality/value The paper offers an alternative view on leadership in the health-care context.

  9. An evidence-based public health approach to climate change adaptation.

    PubMed

    Hess, Jeremy J; Eidson, Millicent; Tlumak, Jennifer E; Raab, Kristin K; Luber, George

    2014-11-01

    Public health is committed to evidence-based practice, yet there has been minimal discussion of how to apply an evidence-based practice framework to climate change adaptation. Our goal was to review the literature on evidence-based public health (EBPH), to determine whether it can be applied to climate change adaptation, and to consider how emphasizing evidence-based practice may influence research and practice decisions related to public health adaptation to climate change. We conducted a substantive review of EBPH, identified a consensus EBPH framework, and modified it to support an EBPH approach to climate change adaptation. We applied the framework to an example and considered implications for stakeholders. A modified EBPH framework can accommodate the wide range of exposures, outcomes, and modes of inquiry associated with climate change adaptation and the variety of settings in which adaptation activities will be pursued. Several factors currently limit application of the framework, including a lack of higher-level evidence of intervention efficacy and a lack of guidelines for reporting climate change health impact projections. To enhance the evidence base, there must be increased attention to designing, evaluating, and reporting adaptation interventions; standardized health impact projection reporting; and increased attention to knowledge translation. This approach has implications for funders, researchers, journal editors, practitioners, and policy makers. The current approach to EBPH can, with modifications, support climate change adaptation activities, but there is little evidence regarding interventions and knowledge translation, and guidelines for projecting health impacts are lacking. Realizing the goal of an evidence-based approach will require systematic, coordinated efforts among various stakeholders.

  10. Differential roles of ventral pallidum subregions during cocaine self-administration behaviors

    PubMed Central

    Root, David H.; Ma, Sisi; Barker, David J.; Megehee, Laura; Striano, Brendan M.; Ralston, Carla M.; Fabbricatore, Anthony T.; West, Mark O.

    2012-01-01

    The ventral pallidum (VP) is necessary for drug-seeking behavior. VP contains ventromedial (VPvm) and dorsolateral (VPdl) subregions which receive projections from the nucleus accumbens shell and core, respectively. To date, no study has investigated the behavioral functions of the VPdl and VPvm subregions. To address this issue, we investigated whether changes in firing rate (FR) differed between VP subregions during four events: approaching toward, responding on, or retreating away from a cocaine-reinforced operandum, and a cocaine-associated cue. Baseline FR and waveform characteristics did not differ between subregions. VPdl neurons exhibited a greater change in FR compared to VPvm neurons during approaches toward, as well as responses on, the cocaine-reinforced operandum. VPdl neurons were more likely to exhibit a similar change in FR (direction and magnitude) during approach and response than VPvm neurons. In contrast, VPvm firing patterns were heterogeneous, changing FRs during approach or response alone, or both. VP neurons did not discriminate cued behaviors from uncued behaviors. No differences were found between subregions during the retreat and no VP neurons exhibited patterned changes in FR in response to the cocaine-associated cue. The stronger, sustained FR changes of VPdl neurons during approach and response may implicate VPdl in the processing of drug-seeking and drug-taking behavior via projections to subthalamic nucleus and substantia nigra pars reticulata. In contrast, heterogeneous firing patterns of VPvm neurons may implicate VPvm in facilitating mesocortical structures with information related to the sequence of behaviors predicting cocaine self-infusions via projections to mediodorsal thalamus and ventral tegmental area. PMID:22806483

  11. Emotion and personal space: Neural correlates of approach-avoidance tendencies to different facial expressions as a function of coldhearted psychopathic traits.

    PubMed

    Vieira, Joana B; Tavares, Tamara P; Marsh, Abigail A; Mitchell, Derek G V

    2017-03-01

    In social interactions, humans are expected to regulate interpersonal distance in response to the emotion displayed by others. Yet, the neural mechanisms implicated in approach-avoidance tendencies to distinct emotional expressions have not been fully described. Here, we investigated the neural systems implicated in regulating the distance to different emotions, and how they vary as a function of empathy. Twenty-three healthy participants assessed for psychopathic traits underwent fMRI scanning while they viewed approaching and withdrawing angry, fearful, happy, sad and neutral faces. Participants were also asked to set the distance to those faces on a computer screen, and to adjust the physical distance from the experimenter outside the scanner. Participants kept the greatest distances from angry faces, and shortest from happy expressions. This was accompanied by increased activation in the dorsomedial prefrontal and orbitofrontal cortices, inferior frontal gyrus, and temporoparietal junction for angry and happy expressions relative to the other emotions. Irrespective of emotion, longer distances were kept from approaching faces, which was associated with increased activation in the amygdala and insula, as well as parietal and prefrontal regions. Amygdala activation was positively correlated with greater preferred distances to angry, fearful and sad expressions. Moreover, participants scoring higher on coldhearted psychopathic traits (lower empathy) showed reduced amygdala activation to sad expressions. These findings elucidate the neural mechanisms underlying social approach-avoidance, and how they are related to variations in empathy. Hum Brain Mapp 38:1492-1506, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  12. [Prophylaxis and therapy of post-traumatic stress disorder with propranolol: evidence and ethical analysis].

    PubMed

    Kühlmeyer, K; Jox, R J

    2013-10-01

    The beta-antagonistic agent propranolol is increasingly being used in clinical trials for the prophylaxis and treatment of post-traumatic stress disorder (PTSD). This article discusses the evidence for the effectiveness of propranolol in the prophylaxis and treatment of PTSD and the ethical implications of research on these treatment approaches. The efficacy of a prophylactic or therapeutic use could not be shown during the last decade. Both treatment approaches raise ethical questions that should already be addressed during the clinical trials.

  13. The Design of an Information Management Program for Headquarters, Department of the Army. Phase 2. Management Summary.

    DTIC Science & Technology

    1980-02-26

    months estimated to be required in some areas), and more direct invol ement of information users in long range planning of information requirements (with...most people, there is a definite need to educate the members of the organization as to the implications of the IRM approach. Emphasis should be placed...from information sharing and a coordinated approach. Such an educational process has already begun with the execution of this study, but more must be

  14. Crew considerations in the design for Space Station Freedom modules on-orbit maintenance

    NASA Technical Reports Server (NTRS)

    Stokes, Jack W.; Williams, Katherine A.

    1992-01-01

    The paper presents an approach to the maintenance process currently planned for the Space Station Freedom modules. In particular, it describes the planned crew interfaces with maintenance items, and the anticipated implications for the crew in performing the interior and exterior maintenance of modules developed by U.S., ESA, and NASDA. Special consideration is given to the maintenance requirements, allocations, and approach; the maintenance design; the Maintenance Workstation; the robotic mechanisms; and the developemnt of maintenance techniques.

  15. “French Phage Network”—Second Meeting Report

    PubMed Central

    Torres-Barceló, Clara; Kaltz, Oliver; Froissart, Rémy; Gandon, Sylvain; Ginet, Nicolas; Ansaldi, Mireille

    2017-01-01

    The study of bacteriophages (viruses of bacteria) includes a variety of approaches, such as structural biology, genetics, ecology, and evolution, with increasingly important implications for therapeutic and industrial uses. Researchers working with phages in France have recently established a network to facilitate the exchange on complementary approaches, but also to engage new collaborations. Here, we provide a summary of the topics presented during the second meeting of the French Phage Network that took place in Marseille in November 2016. PMID:28430166

  16. Moral disengagement and callous unemotional traits configurations in adolescents with disruptive behavior disorder: A person-oriented approach.

    PubMed

    Paciello, Marinella; Masi, Gabriele; Clemente, Maria Grazia; Milone, Annarita; Muratori, Pietro

    2017-12-01

    The interplay between Callous Unemotional Traits (CU) and Moral Disengagement (MD) was examined in a sample of 90 adolescents with Disruptive Behavior Disorders. Using a person-centered approach, three CU and MD configurations were identified, attesting the strong relationship between these two moral dimensions. However, for some adolescents, CU and MD do not 'move together'. Practical implications are discussed in terms of assessment and intervention. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Segmenting hospitals for improved management strategy.

    PubMed

    Malhotra, N K

    1989-09-01

    The author presents a conceptual framework for the a priori and clustering-based approaches to segmentation and evaluates them in the context of segmenting institutional health care markets. An empirical study is reported in which the hospital market is segmented on three state-of-being variables. The segmentation approach also takes into account important organizational decision-making variables. The sophisticated Thurstone Case V procedure is employed. Several marketing implications for hospitals, other health care organizations, hospital suppliers, and donor publics are identified.

  18. A Genetic Approach to Identifying Signal Transduction Mechanisms Initiated by Receptors for TGF-B-Related Factors.

    DTIC Science & Technology

    1998-10-01

    resistant to TGF-ß-induced growth arrest suggest that both types of receptors are required for signaling (Boyd and Massague, 1989; Laiho et ah, 1990...II in TGF-ß- resistant cell mutants implicates both receptor types in signal transduction. J. Biol. Chem. 265, 18518-18524. Lechleider, R. J., de...I-1 « -J AD GRANT NUMBER DAMD17-94-J-4339 TITLE: A Genetic Approach to Identifying Signal Transduction Mechanisms Initiated by Receptors

  19. A numerical evaluation of the dynamical systems approach to wall layer turbulence

    NASA Technical Reports Server (NTRS)

    Berkooz, Gal

    1990-01-01

    This work attempts to test predictions based on the Dynamical Systems approach to Wall Layer Turbulence. We analyze the Dynamical Systems model for the nonlinear interaction mechanisms between the coherent structures and deduce qualitative behavior as expected. We then test for this behavior in data sets from D.N.S. The agreement is good, given the suboptimal conditions for the test. We discuss implications of this test and work to be done to deepen the understanding of control of turbulent boundary layers.

  20. A collaborative approach to team building between staff and students in long-term care.

    PubMed

    Freiburger, O A

    1996-01-01

    Nursing staff and student interactions were not facilitating a system of care that reflected a team effort. Nursing staff and students were involved in efforts to resolve issues that influenced their professional relationships through use of a problem-solving approach. Team-building strategies were implemented, relationships improved, and collaboration increased between nursing staff members and students. Results of this project have implications for the socialization of nursing students and the development of professional relationships in clinical settings.

  1. Neural systems underlying reward and approach behaviors in childhood and adolescence.

    PubMed

    Galván, Adriana

    2014-01-01

    Transitions into and out of adolescence are critical developmental periods of reward-seeking and approach behaviors. Converging evidence suggests that intriguing reward-related behavioral shifts are mediated by developmental changes in frontostriatal circuitry. This chapter explores how the conceptual frameworks and empirical studies in the field of developmental cognitive neuroscience have contributed to understanding reward-related behavior across development.The chapter concludes with some implications for adaptive and maladaptive behaviors that arise from these behaviors as children transition from childhood to adolescence.

  2. Strategy and Structure for Online News Production - Case Studies of CNN and NRK

    NASA Astrophysics Data System (ADS)

    Krumsvik, Arne H.

    This cross-national comparative case study of online news production analyzes the strategies of Cable News Network (CNN) and the Norwegian Broadcasting Corporation (NRK), aiming at understanding of the implications of organizational strategy on the role of journalists, explains why traditional media organizations have a tendency to develop a multi-platform approach (distributing content on several platforms, such as television, online, mobile) rather than developing the cross-media (with interplay between media types) or multimedia approach anticipated by both scholars and practitioners.

  3. Ethical challenges in integrating patient-care with clinical research in a resource-limited setting: perspectives from Papua New Guinea

    PubMed Central

    2013-01-01

    Background In resource-limited settings where healthcare services are limited and poverty is common, it is difficult to ethically conduct clinical research without providing patient-care. Therefore, integration of patient-care with clinical research appears as an attractive way of conducting research while providing patient-care. In this article, we discuss the ethical implications of such approach with perspectives from Papua New Guinea. Discussion Considering the difficulties of providing basic healthcare services in developing countries, it may be argued that integration of clinical research with patient-care is an effective, rational and ethical way of conducting research. However, blending patient-care with clinical research may increase the risk of subordinating patient-care in favour of scientific gains; therapeutic misconception and inappropriate inducement; and the risk of causing health system failures due to limited capacity in developing countries to sustain the level of healthcare services sponsored by the research. Nevertheless, these ethical and administrative implications can be minimised if patient-care takes precedence over research; the input of local ethics committees and institutions are considered; and funding agencies acknowledge their ethical obligation when sponsoring research in resource-limited settings. Summary Although integration of patient-care with clinical research in developing countries appears as an attractive way of conducting research when resources are limited, careful planning and consideration on the ethical implications of such approach must be considered. PMID:23885908

  4. Ethical challenges in integrating patient-care with clinical research in a resource-limited setting: perspectives from Papua New Guinea.

    PubMed

    Laman, Moses; Pomat, William; Siba, Peter; Betuela, Inoni

    2013-07-26

    In resource-limited settings where healthcare services are limited and poverty is common, it is difficult to ethically conduct clinical research without providing patient-care. Therefore, integration of patient-care with clinical research appears as an attractive way of conducting research while providing patient-care. In this article, we discuss the ethical implications of such approach with perspectives from Papua New Guinea. Considering the difficulties of providing basic healthcare services in developing countries, it may be argued that integration of clinical research with patient-care is an effective, rational and ethical way of conducting research. However, blending patient-care with clinical research may increase the risk of subordinating patient-care in favour of scientific gains; therapeutic misconception and inappropriate inducement; and the risk of causing health system failures due to limited capacity in developing countries to sustain the level of healthcare services sponsored by the research. Nevertheless, these ethical and administrative implications can be minimised if patient-care takes precedence over research; the input of local ethics committees and institutions are considered; and funding agencies acknowledge their ethical obligation when sponsoring research in resource-limited settings. Although integration of patient-care with clinical research in developing countries appears as an attractive way of conducting research when resources are limited, careful planning and consideration on the ethical implications of such approach must be considered.

  5. Teacher's experiences in PBL: implications for practice

    NASA Astrophysics Data System (ADS)

    Alves, Anabela C.; Sousa, Rui M.; Fernandes, Sandra; Cardoso, Elisabete; Carvalho, Maria Alice; Figueiredo, Jorge; Pereira, Rui M. S.

    2016-03-01

    Project-Based Learning (PBL) has been implemented in the first year of the Industrial Engineering and Management programme at the University of Minho, Portugal, since 2004/2005. The purpose of this paper is to analyse and discuss teachers' experiences in PBL in this programme and to explore its implications for student learning and for teaching practices in higher education. For data collection, the research method used was written narratives to these teachers, at the end of the PBL semester. Findings suggest that teachers express a positive view of PBL as a learning approach. They identify student motivation and engagement, along with a better understanding of the application of concepts in real-life situations, as important outcomes of the project for students. Besides this, teachers also highlight the importance of the development of transversal skills by students throughout the project. Recommendations for future work and implications for practice will also be discussed.

  6. Toward a new cosmic consciousness: Psychoeducational aspects of contact with extraterrestrial civilizations

    NASA Astrophysics Data System (ADS)

    De la Torre, Gabriel G.

    2014-02-01

    This study presents a new approach to the concept of cosmic consciousness integrated in current neuroscience knowledge and discusses implications for the search for extraterrestrial intelligence. It also examines different aspects related to consciousness and how it may play a key role in the understanding of the search for extraterrestrial intelligence and life in the Universe and its implications. Subjects (n=116) were college students from Spain, the United States, and Italy. Subjects responded to a questionnaire comprising five different sections: (A) religious beliefs, (B) environment and general opinion, (C) astronomy, (D) contact, and (E) attention and perception. The results showed the importance of several modular aspects that affect Space awareness in humans. Preliminary results are discussed with regard to current neuroscience, factor analysis, and possible implications for the understanding of contact with extraterrestrial intelligence. The roles of education, new search strategies, and possible contact scenarios are also discussed.

  7. Squeezing through the Now-or-Never bottleneck: Reconnecting language processing, acquisition, change, and structure.

    PubMed

    Chater, Nick; Christiansen, Morten H

    2016-01-01

    If human language must be squeezed through a narrow cognitive bottleneck, what are the implications for language processing, acquisition, change, and structure? In our target article, we suggested that the implications are far-reaching and form the basis of an integrated account of many apparently unconnected aspects of language and language processing, as well as suggesting revision of many existing theoretical accounts. With some exceptions, commentators were generally supportive both of the existence of the bottleneck and its potential implications. Many commentators suggested additional theoretical and linguistic nuances and extensions, links with prior work, and relevant computational and neuroscientific considerations; some argued for related but distinct viewpoints; a few, though, felt traditional perspectives were being abandoned too readily. Our response attempts to build on the many suggestions raised by the commentators and to engage constructively with challenges to our approach.

  8. Two means of sampling sexual minority women: how different are the samples of women?

    PubMed

    Boehmer, Ulrike; Clark, Melissa; Timm, Alison; Ozonoff, Al

    2008-01-01

    We compared 2 sampling approaches of sexual minority women in 1 limited geographic area to better understand the implications of these 2 sampling approaches. Sexual minority women identified through the Census did not differ on average age or the prevalence of raising children from those sampled using nonrandomized methods. Women in the convenience sample were better educated and lived in smaller households. Modeling the likelihood of disability in this population resulted in contradictory parameter estimates by sampling approach. The degree of variation observed both between sampling approaches and between different parameters suggests that the total population of sexual minority women is still unmeasured. Thoroughly constructed convenience samples will continue to be a useful sampling strategy to further research on this population.

  9. Indigenous Storytelling and Participatory Action Research

    PubMed Central

    2015-01-01

    Storytelling, in its various forms, has often been described as a practice with great emancipatory potential. In turn, Indigenous knowledge shows great promise in guiding a participatory action research (PAR) methodology. Yet these two approaches are rarely discussed in relation to one another, nor, has much been written in terms of how these two approaches may work synergistically toward a decolonizing research approach. In this article, I report on a community-driven knowledge translation activity, the Peoples’ International Health Tribunal, as an exemplar of how narrative and PAR approaches, guided by local Indigenous knowledge, have great potential to build methodologically and ethically robust research processes. Implications for building globally relevant research alliances and scholarship are further discussed, particularly in relation to working with Indigenous communities. PMID:28462305

  10. SCOS 2: ESA's new generation of mission control system

    NASA Technical Reports Server (NTRS)

    Jones, M.; Head, N. C.; Keyte, K.; Howard, P.; Lynenskjold, S.

    1994-01-01

    New mission-control infrastructure is currently being developed by ESOC, which will constitute the second generation of the Spacecraft Control Operations system (SCOS 2). The financial, functional and strategic requirements lying behind the new development are explained. The SCOS 2 approach is described. The technological implications of these approaches is described: in particular it is explained how this leads to the use of object oriented techniques to provide the required 'building block' approach. The paper summarizes the way in which the financial, functional and strategic requirements have been met through this combination of solutions. Finally, the paper outlines the development process to date, noting how risk reduction was achieved in the approach to new technologies and summarizes the current status future plans.

  11. Human factors systems approach to healthcare quality and patient safety

    PubMed Central

    Carayon, Pascale; Wetterneck, Tosha B.; Rivera-Rodriguez, A. Joy; Hundt, Ann Schoofs; Hoonakker, Peter; Holden, Richard; Gurses, Ayse P.

    2013-01-01

    Human factors systems approaches are critical for improving healthcare quality and patient safety. The SEIPS (Systems Engineering Initiative for Patient Safety) model of work system and patient safety is a human factors systems approach that has been successfully applied in healthcare research and practice. Several research and practical applications of the SEIPS model are described. Important implications of the SEIPS model for healthcare system and process redesign are highlighted. Principles for redesigning healthcare systems using the SEIPS model are described. Balancing the work system and encouraging the active and adaptive role of workers are key principles for improving healthcare quality and patient safety. PMID:23845724

  12. Strategies for safe injections.

    PubMed Central

    Battersby, A.; Feilden, R.; Stoeckel, P.; Da Silva, A.; Nelson, C.; Bass, A.

    1999-01-01

    In 1998, faced with growing international concern, WHO set out an approach for achieving injection safety that encompassed all elements from patients' expectations and doctors' prescribing habits to waste disposal. This article follows that lead and describes the implications of the approach for two injection technologies: sterilizable and disposable. It argues that focusing on any single technology diverts attention from the more fundamental need for health services to develop their own comprehensive strategies for safe injections. National health authorities will only be able to ensure that injections are administered safely if they take an approach that encompasses the whole system, and choose injection technologies that fit their circumstances. PMID:10680247

  13. Space Station automated systems testing/verification and the Galileo Orbiter fault protection design/verification

    NASA Technical Reports Server (NTRS)

    Landano, M. R.; Easter, R. W.

    1984-01-01

    Aspects of Space Station automated systems testing and verification are discussed, taking into account several program requirements. It is found that these requirements lead to a number of issues of uncertainties which require study and resolution during the Space Station definition phase. Most, if not all, of the considered uncertainties have implications for the overall testing and verification strategy adopted by the Space Station Program. A description is given of the Galileo Orbiter fault protection design/verification approach. Attention is given to a mission description, an Orbiter description, the design approach and process, the fault protection design verification approach/process, and problems of 'stress' testing.

  14. Gene therapy and its implications in Periodontics

    PubMed Central

    Mahale, Swapna; Dani, Nitin; Ansari, Shumaila S.; Kale, Triveni

    2009-01-01

    Gene therapy is a field of Biomedicine. With the advent of gene therapy in dentistry, significant progress has been made in the control of periodontal diseases and reconstruction of dento-alveolar apparatus. Implementation in periodontics include: -As a mode of tissue engineering with three approaches: cell, protein-based and gene delivery approach. -Genetic approach to Biofilm Antibiotic Resistance. Future strategies of gene therapy in preventing periodontal diseases: -Enhances host defense mechanism against infection by transfecting host cells with an antimicrobial peptide protein-encoding gene. -Periodontal vaccination. Gene therapy is one of the recent entrants and its applications in the field of periodontics are reviewed in general here. PMID:20376232

  15. Diffusion Rates of Organic Molecules in Secondary Organic Aerosol Particle

    NASA Astrophysics Data System (ADS)

    Bertram, A. K.; Chenyakin, Y.; Song, M.; Grayson, J. W.; Ullmann, D.; Evoy, E.; Renbaum-Wolff, L.; Liu, P.; Zhang, Y.; Kamal, S.; Martin, S. T.

    2016-12-01

    Information on the diffusion rates of organic molecules in secondary organic aerosol (SOA) particles are needed when predicting their size distribution, growth rates, photochemistry and heterogeneous chemistry. We have used two approaches to determine diffusion rates of organic molecules in SOA particles and proxies of SOA. In the first approach, we measured viscosities and then predicted diffusion rates using the Stokes-Einstein relation. In the second approach, we measured diffusion rates directly using a technique referred to as fluorescence recovery after photobleaching. Results from these measurements, including diffusion coefficients as a function of water activity, will be presented and the implications discussed.

  16. Adult Learning Theories: Implications for Online Instruction

    ERIC Educational Resources Information Center

    Arghode, Vishal; Brieger, Earl W.; McLean, Gary N.

    2017-01-01

    Purpose: This paper analyzes critically four selected learning theories and their role in online instruction for adults. Design/methodology/approach: A literature review was conducted to analyze the theories. Findings: The theory comparison revealed that no single theory encompasses the entirety of online instruction for adult learning; each…

  17. Implications of Cross-cultural Findings for a Theory of Family Socialisation.

    ERIC Educational Resources Information Center

    Rudy, Duane; Grusec, Joan E.; Wolfe, Janis

    1999-01-01

    Discusses the traditional approach to understanding socialization, focusing on authoritarian and authoritative parenting. Explores authoritative parenting and its promotion of autonomy and authoritarian parenting, considering its effects among cultural groups. Presents data indicating that autonomy support is valued more than power assertion as a…

  18. The Role of the School Psychologist in the Examination of Complex Language Disorders.

    ERIC Educational Resources Information Center

    Werder, Hans

    1988-01-01

    School psychologists must utilize an interdisciplinary approach to understand and analyze language disturbances, by examining the student's motor coordination, sensorium, perception, cognition, emotionality, and sociability. Implications for the practice of school psychology are offered in the areas of dyslalia, dysgrammatia, retardation of…

  19. An Holistic Approach for Counsellors: Embracing Multiple Intelligences

    ERIC Educational Resources Information Center

    Booth, Rosslyn; O'Brien, Patrick John

    2008-01-01

    This paper explores a range of therapeutic modalities used by counsellors of children and positions those modalities within Gardner's theory of multiple intelligences. Research by O'Brien ("Gardner's theory of multiple intelligence and its implications for the counselling of children." Unpublished doctoral dissertation, Queensland University of…

  20. Overeducation and Educational-Occupational Mismatch: A Distinguishing Integration

    ERIC Educational Resources Information Center

    Moore, Sharon; Rosenbloom, Tova

    2016-01-01

    This article accounts for a renovation by enriching the existent literature regarding two major nowadays phenomena and their labor implications, which might require a rethinking regarding new career-development approaches: the overeducation phenomenon (academic graduates whose educational level exceeds the educational level required in their jobs)…

  1. Areas of Learning

    ERIC Educational Resources Information Center

    Coe, John

    2010-01-01

    This article examines the recommendations made by the Independent Review of the Primary Curriculum (the Rose Report in 2009) that the curriculum should be organised into areas of learning. The implications for teachers are considered. By drawing upon past experience some major weaknesses and strengths implicit in the approach are identified and…

  2. Romantic Understanding and Science Education

    ERIC Educational Resources Information Center

    Hadzigeorgiou, Yannis

    2004-01-01

    This essay outlines the potential role for Kieran Egan's (1990) notion of "romantic understanding" in science education. A summary of conventional approaches to science education is followed by a detailed analysis of the implications that romantic understanding may have for the science curriculum, teaching and student learning. In particular the…

  3. Integrated Technologies: An Approach to Establishing Multimedia Applications for Learning.

    ERIC Educational Resources Information Center

    Elmore, Garland C.

    1992-01-01

    Describes a plan for the development of multimedia instruction at Indiana University-Purdue University at Indianapolis (IUPUI). Cooperation between various campus departments is described, including the university libraries. Multimedia systems for permanent installations and portable units are explained, and implications for distance education,…

  4. Inequalities in School Climate in California

    ERIC Educational Resources Information Center

    Jain, Sonia; Cohen, Alison K.; Huang, Kevin; Hanson, Thomas L.; Austin, Gregory

    2015-01-01

    Purpose: School climate, or the physical and social conditions of the learning environment, has implications for academic achievement. The paper aims to discuss this issue. Design/Methodology/Approach: The authors examine how school climate varies by school-level characteristics in California using administrative data and the California School…

  5. Qualitative Audience Research: Toward an Integrative Approach to Reception.

    ERIC Educational Resources Information Center

    Jensen, Klaus Bruhn

    1987-01-01

    Analyzes research about the mass communication audience and describes a theoretical and methodological framework for further empirical studies. Discusses the (1) explanatory value of qualitative research; (2) social and cultural implications of the reception process, with special reference to television; and (3) applications and social relevance…

  6. Prior approval: the growth of Bayesian methods in psychology.

    PubMed

    Andrews, Mark; Baguley, Thom

    2013-02-01

    Within the last few years, Bayesian methods of data analysis in psychology have proliferated. In this paper, we briefly review the history or the Bayesian approach to statistics, and consider the implications that Bayesian methods have for the theory and practice of data analysis in psychology.

  7. Workforce Preparation in a Global Context. Occasional Papers 8.

    ERIC Educational Resources Information Center

    Lasonen, Johanna, Ed.

    This document contains 21 papers and an introduction on work force preparation in a global context. The following papers are included: "Introduction" (Johanna Lasonen); "Access of Girls and Women to Vocational Education: Implications for the Workplace in Swaziland" (Comfort B. S. Mndebele); "Intersectoral Approaches to…

  8. Contrasting LMS Marketing Approaches

    ERIC Educational Resources Information Center

    Carriere, Brain; Challborn, Carl; Moore, James; Nibourg, Theodorus

    2005-01-01

    The first section of this report examines the CourseCompass learning management system (LMS), made available to educators by the Pearson publishing group as a vehicle for the company's extensive content library. The product's features are discussed, and the implications of Pearson's software/textbook "bundling" policy for the integrity of course…

  9. Towards demand-side solutions for mitigating climate change

    NASA Astrophysics Data System (ADS)

    Creutzig, Felix; Roy, Joyashree; Lamb, William F.; Azevedo, Inês M. L.; Bruine de Bruin, Wändi; Dalkmann, Holger; Edelenbosch, Oreane Y.; Geels, Frank W.; Grubler, Arnulf; Hepburn, Cameron; Hertwich, Edgar G.; Khosla, Radhika; Mattauch, Linus; Minx, Jan C.; Ramakrishnan, Anjali; Rao, Narasimha D.; Steinberger, Julia K.; Tavoni, Massimo; Ürge-Vorsatz, Diana; Weber, Elke U.

    2018-04-01

    Research on climate change mitigation tends to focus on supply-side technology solutions. A better understanding of demand-side solutions is missing. We propose a transdisciplinary approach to identify demand-side climate solutions, investigate their mitigation potential, detail policy measures and assess their implications for well-being.

  10. Designing Instruction in the Face of Technology Transience

    ERIC Educational Resources Information Center

    Linder-VanBerschot, Jennifer A.; Summers, Laura L.

    2015-01-01

    As we strive to provide quality and sustainable online learning experiences, we must frame instructional design decisions around learners' current needs and interaction with technology. This article explores the implications of technology transience on instructional design. We provide numerous examples of programs assuming a purposeful approach to…

  11. Comparisons of Watershed Sulfur Budgets in Southeast Canada and Northeast US: New Approaches and Implications

    EPA Science Inventory

    Most of eastern North America receives elevated levels of atmospheric deposition of sulfur (S) that result from anthropogenic SO2 emissions from fossil fuel combustion. Atmospheric S deposition has acidified sensitive terrestrial and aquatic ecosystems in this region; ...

  12. Project on environmentally sustainable transport (EST) : the economic and social implications of sustainable transportation : proceedings from the Ottawa workshop

    DOT National Transportation Integrated Search

    1999-01-01

    It is increasingly clear that current transport systems are not environmentally, and, consequently, not socially or economically, sustainable over the long term. A new policy approach is needed that gives prominence to environmental criteria along wi...

  13. Has Higher Education Been Using the Wrong Marketing Approach?

    ERIC Educational Resources Information Center

    Brooks, Larry R.; Hammons, James O.

    1993-01-01

    It is argued that higher education should be marketing according to principles for marketing services not products. Unique features of services, implications for marketing, and application of service marketing principles to college and university recruitment are explained. Research on seven successfully marketed colleges and universities and…

  14. Ethics and Strategic Therapy: A Proposed Ethical Direction.

    ERIC Educational Resources Information Center

    Solovey, Andrew D.; Duncan, Barry L.

    1992-01-01

    Presents ethical directions in two broad areas often seen as inherent in strategic approach (conscious deception and intervention outside client awareness). Emerging from a discussion of the clinical implications of a constructivist view and a meaning system vocabulary of client change, five ethical presuppositions are exemplified. Discusses…

  15. How Should the Department of Defense Approach Environmental Security Implications of Climate Change

    DTIC Science & Technology

    2009-12-11

    Atlanta: Army Environmental Policy Institute. Kleypas, J. A. 2005. Impacts of ocean acidification on coral reefs and other marine calcifiers. Report......literature review. This chapter includes an introduction to climate change, impacts to the population from sea-level rise, ocean acidification

  16. Implications for Sexual Assault Prevention: College Students as Prosocial Bystanders

    ERIC Educational Resources Information Center

    Exner, Deinera; Cummings, Nina

    2011-01-01

    Prosocial bystander interventions are promising approaches to sexual assault prevention on college campuses. Objective: To assess bystander attitudes among undergraduate students at a northeastern university. Participants: A convenience sample of 188 students from 4 undergraduate classes was surveyed during regularly scheduled class sessions.…

  17. Culturally Responsive Integrative Learning Environments: A Critical Displacement Approach.

    PubMed

    Mahoney, Antron D

    2016-12-01

    This chapter outlines a critical framework for developing culturally responsive integrative learning environments in leadership education. The framework is grounded in the scholarship of women of color feminism and offers implications for transforming curricular and cocurricular leadership programs. © 2016 Wiley Periodicals, Inc., A Wiley Company.

  18. Effectiveness of Abstinence-Based Sex Education Curricula: A Review.

    ERIC Educational Resources Information Center

    Toups, Melanie L.; Holmes, William R.

    2002-01-01

    Many attempts have been made to address the problem of teenage premarital sexual activity in order to reduce the number of pregnancies and sexually transmitted diseases. The authors review some of those efforts and attempt to identify effective approaches. Implications for research are also presented. (Author)

  19. Knowledge Democracy and the Implications to Information Access

    ERIC Educational Resources Information Center

    Raza, Ahmad; Murad, Hasan Sohaib

    2008-01-01

    Purpose: The purpose of this paper is to examine the concept of "knowledge democracy," deploying a pluralistic, and cross disciplinary and humanistic critique. Design/methodology/approach: This is a culturally pluralistic and humanistic interpretation of globally emergent form of learning pedagogy, particularly manifested in e-learning.…

  20. Student Misconceptions of an Electric Circuit: What Do They Mean?

    ERIC Educational Resources Information Center

    Fredette, Norman H.; Clement, John J.

    1981-01-01

    Discusses a common misconception in the area of electric circuits at the level of introductory college physics. The data, collected from clinical interviews, shed light on the cognitive sources of misconception. Also discusses some implications for laboratory approaches used in science courses. (Author/SK)

  1. The Right to Literacy.

    ERIC Educational Resources Information Center

    Lunsford, Andrea A., Ed.; And Others

    This book contains 29 essays which grew out of presentations delivered at a conference on the right to literacy whose participants were invited to consider differing definitions and historical understandings of literacy and the political, pedagogical, and theoretical implications of the many approaches to literacy education that have been taken…

  2. Is there a genetic solution to bovine respiratory disease complex?

    USDA-ARS?s Scientific Manuscript database

    Bovine respiratory disease complex (BRDC) is a complex multi-factor disease, which increases costs and reduces revenue from feedlot cattle. Multiple stressors and pathogens (viral and bacterial) have been implicated in the etiology of BRDC, therefore multiple approaches will be needed to evaluate a...

  3. Understanding Sensory Integration. ERIC Digest.

    ERIC Educational Resources Information Center

    DiMatties, Marie E.; Sammons, Jennifer H.

    This brief paper summarizes what is known about sensory integration and sensory integration dysfunction (DSI). It outlines evaluation of DSI, treatment approaches, and implications for parents and teachers, including compensatory strategies for minimizing the impact of DSI on a child's life. Review of origins of sensory integration theory in the…

  4. A Multidimensional Approach to the Structure of Consumer Satisfaction with Vocational Rehabilitation Services.

    ERIC Educational Resources Information Center

    Kosciulek, John E.

    2003-01-01

    This investigation examines the dimensions underlying consumer satisfaction with vocational rehabilitation services. Findings suggest that consumers view satisfaction as a multidimensional construct. Implications for the measurement of consumer satisfaction and use of consumer satisfaction data in vocational rehabilitation program evaluations are…

  5. Brain-(Not) Based Education: Dangers of Misunderstanding and Misapplication of Neuroscience Research

    ERIC Educational Resources Information Center

    Alferink, Larry A.; Farmer-Dougan, Valeri

    2010-01-01

    Oversimplification or inappropriate interpretation of complex neuroscience research is widespread among curricula claiming that brain-based approaches are effective for improved learning and retention. We examine recent curricula claiming to be based on neuroscience research, discuss the implications of such misinterpretation for special…

  6. Two Kinds of "Elements" and the Dialectic between Synthetic-deductive and Analytic-genetic Approaches in Mathematics.

    ERIC Educational Resources Information Center

    Steiner, Hans-Georg

    1988-01-01

    Describes two kinds of elements in mathematics: Euclid's and Bourbaki's. Discusses some criticisms on the two concepts of elements from a philosophical, methodological, and didactical point of view. Suggests a complementarist view and several implications for mathematics education. (YP)

  7. Left Brain to Right Brain: Notes from the Human Laboratory.

    ERIC Educational Resources Information Center

    Baumli, Francis

    1982-01-01

    Examines the implications of the left brain-right brain theory on communications styles in male-female relationships. The author contends that women tend to use the vagueness of their emotional responses manipulatively. Men need to apply rational approaches to increase clarity in communication. (AM)

  8. Molecular neurobiology in neurology and psychiatry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kandel, E.R.

    1987-01-01

    This book contains 14 selections. Some of the titles are: An Introduction to Ion Channels; Molecular Neurobiology of the Myelinated Nerve Fiber: Ion-Channel Distributions and Their Implications for Demyelinating Diseases; A Molecular Genetic Approach to Huntington's Disease; and Molecular Features of Cell Adhesion Molecules Involved in Neural Development.

  9. Grammaire nouvelle? Questions pour des questions (New Grammar? Questions about Questions).

    ERIC Educational Resources Information Center

    Lamy, Andre

    1987-01-01

    Implications of the "new grammar" approach to teaching French are examined, including the issues of nomenclature, definition, rules and generalizations, and native language use in the second language class. Grammar itself has not changed, and the principal concern is still good usage. (MSE)

  10. Concepts of sustainability, motivations for pest management approaches, and implications for communicating change

    USDA-ARS?s Scientific Manuscript database

    Effective communication with farmers is an essential component of impacting their decision processes and encouraging changes in pest management practices, but requires a system of research and extension management that differs from that to which most biological scientists are accustomed. We present...

  11. Carl Rogers' Alternative to Traditional Rhetoric.

    ERIC Educational Resources Information Center

    Hairston, Maxine C.

    Carl Rogers' approach to communication has implications for the rhetorician and the teacher of college composition. The qualities of respect, restraint, neutrality, and understanding, when applied to written and oral discourse, can provide an effective alternative to polemical argumentation. The detatchment and empathy of the Rogerian style is…

  12. Vocabulary Acquisition: Implications for Reading Comprehension

    ERIC Educational Resources Information Center

    Wagner, Richard K., Ed.; Muse, Andrea E., Ed.; Tannenbaum, Kendra R., Ed.

    2006-01-01

    Understanding a text requires more than the ability to read individual words: it depends greatly on vocabulary knowledge. This important book brings together leading literacy scholars to synthesize cutting-edge research on vocabulary development and its connections to reading comprehension. The volume also reviews an array of approaches to…

  13. Themes of Hope and Healing: Infertile Couples' Experiences of Adoption.

    ERIC Educational Resources Information Center

    Daniluk, Judith C.; Hurtig-Mitchell, Joss

    2003-01-01

    Using qualitative approach, authors explored the experiences of becoming parents through adoption after unsuccessful infertility treatments. Analysis of data revealed three overarching themes. Findings are discussed in terms of their implications for counselors who work with infertile couples considering adoption, clients engaged in adoption…

  14. Educational "Testimonio": Critical Pedagogy as Mentorship

    ERIC Educational Resources Information Center

    Burciaga, Rebeca; Cruz Navarro, Natalia

    2015-01-01

    This chapter chronicles the use of educational "testimonio" as one approach to critical pedagogy as mentoring in a college classroom. Written from the perspectives of an instructor and a student, it explores educational "testimonio" as one tool that has implications beyond the classroom, including retention in higher education…

  15. The Psychological Rights of the Child: Spiritual and Moral Development.

    ERIC Educational Resources Information Center

    Grimley, Liam K.

    1982-01-01

    The history of American education's efforts to fulfill responsibilities for the moral and spiritual development of students is described. Views of Kohlberg and Fowler concerning stages of development are discussed. Recent research findings are presented, and implications for educational approaches are suggested. (Author/PP)

  16. The technology-science relationship: Some curriculum implications

    NASA Astrophysics Data System (ADS)

    Gardner, Paul L.

    1990-01-01

    Technology encompasses the goods and services which people make and provide to meet human needs, and the processes and systems used for their development and delivery. Although technology and science are related, a distinction can be made between their purposes and outcomes. This paper considers four possible approaches to teaching students about the relationship between technology and science. A technology-as-illustration approach treats technology as if it were applied science; artefacts are presented to illustrate scientific principles. A cognitive-motivational approach also treats technology as applied science, but presents technology early in the instructional sequence in order to promote student interest and understanding. In an artefact approach, learners study artefacts as systems in order to understand the scientific principles which explain their workings. Finally, a technology-as-process approach emphasises the role of technological capability; in this approach, scientific concepts do not have privileged status as a basis for selecting curriculum content.

  17. Trait approach motivation moderates the aftereffects of self-control

    PubMed Central

    Crowell, Adrienne; Kelley, Nicholas J.; Schmeichel, Brandon J.

    2014-01-01

    Numerous experiments have found that exercising self-control reduces success on subsequent, seemingly unrelated self-control tasks. Such evidence lends support to a strength model that posits a limited and depletable resource underlying all manner of self-control. Recent theory and evidence suggest that exercising self-control may also increase approach-motivated impulse strength. The two studies reported here tested two implications of this increased approach motivation hypothesis. First, aftereffects of self-control should be evident even in responses that require little or no self-control. Second, participants higher in trait approach motivation should be particularly susceptible to such aftereffects. In support, exercising self-control led to increased optimism (Study 1) and broadened attention (Study 2), but only among individuals higher in trait approach motivation. These findings suggest that approach motivation is an important key to understanding the aftereffects of exercising self-control. PMID:25324814

  18. The early benefits of a problem-based approach to teaching social inclusion using an online virtual town.

    PubMed

    Beadle, Mary; Santy, Julie

    2008-05-01

    This article describes the delivery of a core pre-registration nursing and midwifery module centred on social inclusion. The module was previously delivered using a classroom-based problem-based learning approach. Difficulties with this approach led to changes to the module and its delivery. Logistic issues encouraged the module team to implement a blended learning approach using a virtual town to facilitate online learning and discussion activities. The paper describes and discusses the use of online learning technology to support student nurses and midwives. It highlights the benefits of this approach and outlines some of the experiences of the students including their evaluation of the virtual town. There is also an examination of some of the practical and theoretical issues related to both problem-based learning, online working and using a virtual town to support learning. This article outlines the approach taken and its implications.

  19. A probiotic approach to caries management.

    PubMed

    Anderson, M H; Shi, W

    2006-01-01

    The surgical approach has been the predominate mode of caries management for the past 150 years. Dentistry has, however, in recent years moved toward an antibiotic/antimicrobial model of disease management. This approach, however, raises serious questions: (1) do the antibiotic/antimicrobial agents (chlorhexidine, povidone iodine, fluoride, etc) kill all offending organisms?; (2) if so, do the agents preclude the re-entry of the same organisms from external sources?; and (3) if the agents do kill all the offending organisms, do any remaining pathogenic organisms have selective advantage in repopulating the tooth surfaces? To overcome the problems inherent in an antibiotic/antimicrobial approach, probiotic methods are currently under study as means of caries management. This paper discusses probiotic approaches, such as genetically modified Streptococcus mutans and targeted antimicrobials in the management of dental caries. Implications for this approach in the management of other diseases are also presented.

  20. Is moral elevation an approach-oriented emotion?

    PubMed Central

    Van de Vyver, Julie; Abrams, Dominic

    2017-01-01

    Abstract Two studies were designed to test whether moral elevation should be conceptualized as an approach-oriented emotion. The studies examined the relationship between moral elevation and the behavioral activation and inhibition systems. Study 1 (N = 80) showed that individual differences in moral elevation were associated with individual differences in behavioral activation but not inhibition. Study 2 (N = 78) showed that an elevation-inducing video promoted equally high levels of approach orientation as an anger-inducing video and significantly higher levels of approach orientation than a control video. Furthermore, the elevation-inducing stimulus (vs. the control condition) significantly promoted prosocial motivation and this effect was sequentially mediated by feelings of moral elevation followed by an approach-oriented state. Overall the results show unambiguous support for the proposal that moral elevation is an approach-oriented emotion. Applied and theoretical implications are discussed. PMID:28191027

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