Flexible Work Arrangements in ARL Libraries. SPEC Kit #180.

ERIC Educational Resources Information Center

Zabel, Diane, Comp.; And Others

This report presents the results of a survey of Association of Research Libraries (ARL) members about the current climate and practices regarding flexible work arrangements. Data are reported on the availability of schedule flexibility, job exchange, part-time arrangements, and leaves, as well as information about faculty status, tenure,…

Preparation and Presentation of the Library Budget. SPEC Kit 32.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit on the preparation and presentation of the library budget in Association of Research Libraries (ARL) institutions contains a concise summary of the results of a 1977 member survey on budget preparation and eight related primary source documents. The summary of the Systems and Procedures Exchange Center (SPEC) survey focuses on types of…

Electronic Reference Service. SPEC Kit 251.

ERIC Educational Resources Information Center

Goetsch, Lori, Comp.

1999-01-01

The goals of this SPEC Kit were to report on the extent to which ARL (Association of Research Libraries) libraries provide electronic reference services and to offer a snapshot of the types of users reached, questions received, policies established, data-gathering techniques utilized, and innovations implemented. The first section of the kit…

Managing Corporate Annual Reports. SPEC Kit 258.

ERIC Educational Resources Information Center

O'Connor, Lisa, Comp.

2000-01-01

The purpose of the survey for this SPEC (Systems and Procedures Exchange Center) Kit was to assess the current print corporate annual report collection practices of ARL (Association of Research Libraries) libraries, describe the effects of these collections, and recommend best practices for preserving these significant historical documents. The…

Scholarly Information Centers in ARL Libraries. SPEC Kit 175.

ERIC Educational Resources Information Center

Allen, Nancy, Comp.; Godden, Irene, Comp.

Noting that the rapid evolution of telecommunications technology, the relentless advancement of computing capabilities, and the seemingly endless proliferation of electronic data have had a profound impact on research libraries, this Systems and Procedures Exchange Center (SPEC) kit explores the extent to which these technologies have come…

Networked Information Resources. SPEC Kit 253.

ERIC Educational Resources Information Center

Bleiler, Richard, Comp.; Plum, Terry, Comp.

1999-01-01

This SPEC Kit, published six times per year, examines how Association of Research Libraries (ARL) libraries have structured themselves to identify networked information resources in the market, to evaluate them for purchase, to make purchasing decisions, to publicize them, and to assess their continued utility. In the summer of 1999, the survey…

Access Services: Organization and Management. SPEC Kit #179.

ERIC Educational Resources Information Center

Steel, Virginia, Comp.

This Systems and Exchange Center (SPEC) kit begins with a summary by Virginia Steel of the findings of a survey of Association of Research Libraries (ARL) member libraries that was conducted in 1991 to determine the prevalence of the organizational model of access services--i.e., a department or division responsible for the services and operations…

Telecommunications in ARL Libraries. SPEC Kit 98.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This 11-document kit introduces the current and planned uses of telecommunications facilities in the computerized information systems of several research libraries, public libraries, and library groups contacted in 1983. The first two documents are excerpts from reports on networks: "Telecommunications: An Overview for OCLC," and…

Collection Assessment. SPEC Kit 41.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This Association of Research Libraries (ARL) kit on collection assessment contains the following documents: (1) "Guidelines for the Evaluation of Library Collections--Draft Copy" (Collection Development Committee, Resource Section, Resources and Technical Services Division, American Library Association); (2) "Guidelines for Collection Assessment"…

Determining Indirect Cost Rates in Research Libraries. SPEC Kit 34.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit prepared by the Association of Research Libraries (ARL) contains 15 primary source documents on determining indirect cost rates in research libraries. The kit comprises: (1) six library cost studies and surveys, "Allocation of Library Expenditures to Research and Instruction" (University of Pennsylvania), "Sampling of Current Monograph…

The Integration of Nonprint Media. SPEC Kit 33.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit on the integration of nonprint media into Association of Research Libraries (ARL) institutions contains a concise summary of a 1977 phone survey with ARL members, eight descriptions of programs and services, and five acquisition and processing policies. To collect data on practices regarding the acquisition, processing, and use of…

Goals & Objectives Statements. SPEC Kit 15.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This collection of statements of goals and objectives from member libraries of the Association of Research Libraries (ARL) contains: (1) sections from management review and analysis program reports from the University of Washington Libraries and the University of Rochester Library; (2) a detailed organization description from the Columbia…

Preservation of Library Materials. SPEC Kit 35.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This Association of Research Libraries (ARL) kit on preservation of library materials contains: (1) descriptions of preservation programs and objectives from Boston University, the University of Michigan, University of Wisconsin, and University of California at Los Angeles; (2) a description of the Library of Congress' National Preservation…

Grievance Procedures. SPEC Kit 23.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This collection of grievance procedures from member libraries of the Association of Research Libraries (ARL) contains: (1) documents on committee approaches to grievances from University of British Columbia, Center for Research Libraries, University of Connecticut, Harvard University, Michigan State University, and University of Nebraska; (2)…

Planning Systems. SPEC Kit 13.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit on planning systems updates a 1974 Management Studies Office Systems and Procedures Exchange Center (SPEC) kit in which developments in planning activities among Association of Research Libraries (ARL) were reviewed. At the time of the original study, in 1972, planning techniques and systems were a subject of much interest because rising…

User Statistics and Studies. SPEC Kit 25.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

A result of the Association of Research Libraries' (ARL) November 1975 Services Survey, this kit presents statistical studies developed from management information sources such as circulation records or generated expressly for a particular study. While academic and research libraries maintain statistical records measuring library efficiency or…

Acquisition Policies. SPEC Kit 12.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This collection of acquisition materials from member libraries of the Association of Research Libraries (ARL) contains: (1) acquisition policies from Brigham Young University, Iowa State University, and the University of Cincinnati; (2) book selection policies from the University of Nebraska Undergraduate Library and Georgetown University; (3) an…

Computerized Online Bibliographic Searching. SPEC Kit #154.

ERIC Educational Resources Information Center

Hocker, Susan

For this kit, 106 Association of Research Libraries (ARL) academic libraries were surveyed concerning: (1) current administration/organization; (2) evaluation; (3) patron relations; (4) services; and (5) the impact of online searching on collections. Responses were received from 83 libraries, many of which contributed sample materials. Analyses of…

Evolution & Status of Approval Plans. SPEC Kit 221.

ERIC Educational Resources Information Center

Flood, Susan, Comp.

This report documents the results of a survey on the current use and management of approval plans, and compares them with similar studies published in SPEC kits in 1982 and 1988. Overall, Association of Research Libraries (ARL) institutions still consider approval plans to be efficient and cost effective. Survey results include: (1) the percentage…

Marketing and Public Relations in ARL Libraries. SPEC Kit 240.

ERIC Educational Resources Information Center

Smykla, Evelyn Ortiz, Comp.

1999-01-01

This survey was conducted to delineate the growing relationship between marketing and public relations and library funding by identifying: (1) the extent to which North American research libraries have developed organized programs in the areas of marketing and public relations; (2) who holds positions in these areas; and (3) the impact these…

Collection Development Policies. SPEC Kit 38.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

Responses from 54 libraries to a 1977 survey of Association of Research Libraries (ARL) member institutions and interviews by Office of Management Studies staff members who visited another 15 indicated that 20 of the 69 libraries had and made use of a written collection development policy. Eight others reported that such a policy was being…

Technical Services Workstations. SPEC Kit 213.

ERIC Educational Resources Information Center

Brugger, Judith M., Comp.; And Others

Technical services workstations (TSWs) are personal computers that have been customized for use in technical services departments. To gather information on their use and prevalence in research libraries, the Program for Cooperative Cataloging Standing Committee on Automation surveyed the 119 members of the Association of Research Libraries (ARL)…

Provision of Computer Printing Capabilities to Library Patrons. SPEC Kit 183.

ERIC Educational Resources Information Center

Taylor, Suzanne; Welch, C. Brigid, Ed.

1992-01-01

This publication reports on the results of a 1992 survey of 80 Association of Research Libraries (ARL) member libraries on their use of printers for recording references found in online public access catalog (OPAC) and CD-ROM searches. As was found in a 1990 survey on the same topic, only a small proportion of libraries reported that they charged…

Building Security and Personal Safety. SPEC Kit 150.

ERIC Educational Resources Information Center

Bingham, Karen Havill

This report on a survey of Association of Research Libraries (ARL) member libraries on building security and personal safety policies examines three areas in detail: (1) general building security (access to the building, key distribution, patrols or monitors, intrusion prevention, lighting, work environment after dark); (2) problem behavior…

The Changing Role of Book Repair in ARL Libraries. SPEC Kit #190.

ERIC Educational Resources Information Center

Silverman, Randy, Comp.; Grandinette, Maria, Comp.

This kit provides 24 essays on book repair: (1) "Conservation at the American Philosophical Society: An Institutional Profile in 1992" (H. Kyle); (2) "The Book Repair Program at Brigham Young University: An Institutional Profile" (R. Silverman); (3) "Book Repair and Conservation: Conservation Center for Art and Historic…

ARL: A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC. Number 257

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2008-01-01

ARL is the bimonthly report on research library issues and actions from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). ARL reports on current issues of interest to academic and research library administrators, staff, and users; higher education…

ARL: A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC. Number 241

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2005-01-01

ARL is the bimonthly report on research library issues and actions from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). ARL reports on current issues of interest to academic and research library administrators, staff, and users; higher education…

ARL: A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC. Number 244

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2006-01-01

ARL is the bimonthly report on research library issues and actions from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). ARL reports on current issues of interest to academic and research library administrators, staff, and users; higher education…

ARL: A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC. Number 233

ERIC Educational Resources Information Center

Barrett, Jaia, Ed.

2004-01-01

ARL is the bimonthly report on research library issues and actions from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). ARL reports on current issues of interest to academic and research library administrators, staff, and users; higher education…

ARL: A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC. Number 251

ERIC Educational Resources Information Center

Association of Research Libraries, 2007

2007-01-01

ARL is the bimonthly report on research library issues and actions from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). ARL reports on current issues of interest to academic and research library administrators, staff, and users; higher education…

Electronic Journals in Academic Libraries: A Comparison of ARL and Non-ARL Libraries.

ERIC Educational Resources Information Center

Shemberg, Marian; Grossman, Cheryl

1999-01-01

Describes a survey dealing with academic library provision of electronic journals and other electronic resources that compared ARL (Association of Research Libraries) members to non-ARL members. Highlights include full-text electronic journals; computers in libraries; online public access catalogs; interlibrary loan and electronic reserves; access…

ARL: A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC. Special Double Issue on New Measures. Number 230-231, October-December 2003

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2003-01-01

ARL is the bimonthly report on research library issues and actions from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). ARL reports on current issues of interest to academic and research library administrators, staff, and users; higher education…

ARL Supplementary Statistics, 2007-2008

ERIC Educational Resources Information Center

Bland, Les, Comp.; Kyrillidou, Martha, Comp.

2009-01-01

This report presents statistics on how Association of Research Libraries (ARL) member libraries spend money on electronic resources. This report indicates that 109 ARL libraries purchased 32,329,187 electronic books. In 2007-2008, there was a median of 28,319 acquisitions of electronic books by ARL libraries (this includes one institution that…

ARL Academic Health Sciences Library Statistics, 2000-01.

ERIC Educational Resources Information Center

Young, Mark, Comp.; Kyrillidou, Martha, Comp.

This document presents results of the 2000-01 Association of Research Libraries (ARL) Medical Library Statistics Questionnaire. Of 113 ARL university libraries, 63 responded to the survey. Results for each library are presented in the following data tables: (1) collections, including volumes in library, volumes added, monographs purchased, current…

ARL Academic Law Library Statistics, 2007-2008

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Bland, Les, Comp.

2009-01-01

This document presents results of the 2007-2008 Association of Research Libraries (ARL) Law Library Statistics Questionnaire. Of 113 ARL university libraries, 74 responded to the survey. Results for each library are presented in the following data tables: (1) collections (2-parts), including volumes in library, volumes added, monographs purchased,…

ARL Academic Law Library Statistics 2006-2007

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Bland, Les, Comp.

2008-01-01

This document presents results of the 2006-2007 Association of Research Libraries (ARL) Law Library Statistics Questionnaire. Of 113 ARL university libraries, 74 responded to the survey. Results for each library are presented in the following data tables: (1) collections (2-parts), including volumes in library, volumes added, monographs purchased,…

ARL Annual Salary Survey, 2009-2010

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Bland, Les, Comp.

2010-01-01

The "ARL Annual Salary Survey 2009-2010" reports salary data for all professional staff working in ARL libraries. The Association of Research Libraries (ARL) represents the interests of libraries that serve major North American research institutions. Data for 10,207 professional staff members were reported this year for the 114 ARL…

ARL Annual Salary Survey, 2008-2009

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Bland, Les, Comp.

2009-01-01

The "ARL Annual Salary Survey, 2008-2009" reports salary data for all professional staff working in ARL libraries. The Association of Research Libraries (ARL) represents the interests of libraries that serve major North American research institutions. Data for 10,148 professional staff members were reported this year for the 113 ARL…

ARL Supplementary Statistics, 2006-2007

ERIC Educational Resources Information Center

Bland, Les, Comp.; Kyrillidou, Martha, Comp.

2009-01-01

This report presents statistics on how Association of Research Libraries (ARL) member libraries spend money on electronic resources. This report indicates that 108 ARL libraries purchased 25,006,758 electronic books. In 2006-2007, there was an ARL median of 243,725 acquisitions of electronic books (this includes one institution that purchased…

ARL Annual Salary Survey, 2000-2001.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Wetzel, Karen, Comp.

This document reports the 2000-2001 salary data for all professional staff working in ARL (Association of Research Libraries) libraries. Data for 8,882 professional staff members were reported for the 112 ARL university libraries, including their law and medical libraries (811 staff members reported by 68 medical libraries and 708 staff members…

ARL Annual Salary Survey, 1999-2000.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; O'Connor, Michael, Comp.

This document reports 1999-2000 salary data for all professional staff working in ARL (Association of Research Libraries) libraries. Data for 8,595 professional staff members were reported for the 111 ARL university libraries, including their law and medical libraries (814 staff members reported by 69 medical libraries and 660 staff members…

ARL Annual Salary Survey, 2002-2003.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

This document reports the 2001-2002 salary data for all professional staff working in ARL (Association of Research Libraries) libraries. Data for 9,469 professional staff members were reported for the 124 ARL university libraries, including their law and medical libraries (909 staff members reported by 69 medical libraries and 726 staff members…

ARL Annual Salary Survey, 2001-02.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

This document reports the 2001-2002 salary data for all professional staff working in ARL (Association of Research Libraries) libraries. Data for 9,198 professional staff members were reported for the 1,130 ARL university libraries, including their law and medical libraries (859 staff members reported by 69 medical libraries and 724 staff members…

Graphic Novel Collections in Academic ARL Libraries

ERIC Educational Resources Information Center

Wagner, Cassie

2010-01-01

This study examines the extent to which ARL academic libraries collect graphic novels. Using a core list of 176 titles developed from winners of major comics industry awards and a library-focused "best of" list, the holdings of 111 ARL academic libraries were searched using the libraries' online catalogs. Results suggest that most of the…

ARL Annual Salary Survey 2003-04

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

2004-01-01

The Association of Research Libraries (ARL) Annual Salary Survey 2003-04 reports salary data for all professional staff working in Association of Research Libraries (ARL) libraries. It is the most comprehensive and thorough guide to current salaries in large U.S. and Canadian academic and research libraries, and is a valuable management and…

ARL Statistics, 1999-2000: A Compilation of Statistics from the One Hundred and Twenty-Two Members of the Association of Research Libraries.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

This is the latest in a series of annual publications that describe collections, staffing, expenditures, and service activities for the 122 member libraries of the Association of Research Libraries (ARL). Of these, 112 are universities libraries; the remaining 10 are public, governmental, and private research libraries. ARL member libraries are…

Fund Raising in ARL Libraries. Kit 94.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

In January 1983 the Association of Research Libraries (ARL) surveyed its members regarding their fund raising programs. A response rate of 85% (95 out of 113 libraries surveyed) was obtained. It was found that 85% of ARL member libraries had been involved in university-wide fund campaigns; that over 75% of the respondents had also conducted…

ARL Profiles: Research Libraries 2010

ERIC Educational Resources Information Center

Potter, William Gray; Cook, Colleen; Kyrillidou, Martha

2011-01-01

The current ARL report summarizes a multi-year effort that captures evidence in the form of narrative profiles as it delivers the message of the value and contributions of research libraries during transformative times. When ARL library directors were interviewed in 2005 and asked to describe a research library in the 21st century, there was…

ARL Statistics, 2000-01: A Compilation of Statistics from the One Hundred and Twenty-Four Members of the Association of Research Libraries.

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

This document is the latest in a series of annual publications that describe collections, staffing, expenditures, and service activities for the 123 members of the Association of Research Libraries (ARL). Of these, 113 are university libraries; the remaining 10 are public, governmental, and private research libraries. ARL member libraries are the…

Paraprofessional of the Year 2007: Jackie Cornette

ERIC Educational Resources Information Center

Berry, John N., III

2007-01-01

Jackie Cornette is manager of the Western Branch of the Watauga County Library (WCL) in North Carolina. WCL is one of three county library systems that comprise the Appalachian Regional Library (ARL), headquartered in North Wilkesboro, North Carolina. According to Louise Humphrey, ARL director, Cornette has been a shining star in ARL since 1988.…

Research Library Issues: A Bimonthly Report from ARL, CNI, and SPARC. RLI 270

ERIC Educational Resources Information Center

Baughman, M. Sue, Ed.

2010-01-01

"Research Library Issues" ("RLI") is a bimonthly report from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). This issue includes the following articles: (1) Celebrating 10 Years of ARL's Initiative to Recruit a Diverse Workforce (Mark A. Puente);…

ARL Annual Salary Survey, 2006-07. Revised

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

2007-01-01

The "ARL Annual Salary Survey 2006-07" reports salary data for all professional staff working in Association of Research Libraries (ARL) libraries. It is the most comprehensive and thorough guide to current salaries in large U.S. and Canadian academic and research libraries, and is a valuable management and research tool. Data for 9,824…

ARL Annual Salary Survey 2005-06

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Young, Mark, Comp.

2006-01-01

The "ARL Annual Salary Survey 2005-06" reports salary data for all professional staff working in Association of Research Libraries (ARL) libraries. It is the most comprehensive and thorough guide to current salaries in large U.S. and Canadian academic and research libraries, and is a valuable management and research tool. Data for 9,655…

ARL Annual Salary Survey 2007-2008

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp; Young, Mar, Comp.; Barber, Jason, Comp.

2008-01-01

The "ARL Annual Salary Survey 2007-2008" reports salary data for all professional staff working in Association of Research Libraries (ARL) libraries. It is the most comprehensive and thorough guide to current salaries in large U.S. and Canadian academic and research libraries, and is a valuable management and research tool. Data for 9,983…

Research Library Issues: A Bimonthly Report from ARL, CNI, and SPARC. RLI 268

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2010-01-01

"Research Library Issues" ("RLI") is a bimonthly report from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). This special issue includes the following articles: (1) Themes within the ARL Strategic Plan 2010-2012 (Charles B. Lowry); (2) ARL…

ARL: A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC. Special Issue on the Role of the Library in a Digital Landscape, Number 243

ERIC Educational Resources Information Center

Bowen, William G.; Barrett, G. Jaia, Ed.

2005-01-01

This special issue of "ARL: A Bimonthly Report" contains the remarks that William G. Bowen delivered to the research library community in October 2005 at the 147th Membership Meeting of ARL. For the past 17 years Dr. Bowen has served as President of The Andrew W. Mellon Foundation. In these remarks, entitled "New Times Always; Old Time We Cannot…

A New Culture of Assessment: Preliminary Report on the ARL SERVQUAL Survey.

ERIC Educational Resources Information Center

Cook, Colleen; Heath, Fred; Thompson, Bruce

Texas A&M University and the Association of Research Libraries (ARL) under the New Measures initiative are engaged in a project to evaluate service quality in research libraries using an augmented SERVQUAL instrument. In spring 2000, 13 ARL libraries in North America invited a random sample of students and faculty to take the survey through…

Management Preparation and Training of Department Heads in ARL Libraries.

ERIC Educational Resources Information Center

Wittenbach, Stefanie A.; And Others

1992-01-01

A survey of cataloging and reference department heads in ARL (Association for Research Libraries) member libraries showed that both professional experience and management coursework play a part in a librarian's promotion to department head. It is suggested that library management will improve if libraries require formal management preparation and…

Accessing Digital Libraries: A Study of ARL Members' Digital Projects

ERIC Educational Resources Information Center

Kahl, Chad M.; Williams, Sarah C.

2006-01-01

To ensure efficient access to and integrated searching capabilities for their institution's new digital library projects, the authors studied Web sites of the Association of Research Libraries' (ARL) 111 academic, English-language libraries. Data were gathered on 1117 digital projects, noting library Web site and project access, metadata, and…

The Automation Inventory of Research Libraries, 1986.

ERIC Educational Resources Information Center

Sitts, Maxine K., Ed.

Based on information and data from 113 Association of Research Libraries (ARL) members that were gathered and updated between March and August 1986, this publication was generated from a database developed by ARL to provide timely, comparable information about the extent and nature of automation within the ARL community. Trends in automation are…

Relationships between Association of Research Libraries (ARL) Statistics and Bibliometric Indicators: A Principal Components Analysis

ERIC Educational Resources Information Center

Hendrix, Dean

2010-01-01

This study analyzed 2005-2006 Web of Science bibliometric data from institutions belonging to the Association of Research Libraries (ARL) and corresponding ARL statistics to find any associations between indicators from the two data sets. Principal components analysis on 36 variables from 103 universities revealed obvious associations between…

It Didn't Have to Be This Way: Entrepreneurship at ARL during Duane Webster's Tenure

ERIC Educational Resources Information Center

Guthrie, Kevin M.

2009-01-01

The Association of Research Libraries (ARL) has a long history of leadership as an important membership organization serving the research library community. A reading of its history highlights a substantial shift in its methods of community leadership in recent decades. Historically, like most membership organizations, ARL was largely focused on…

Research Library Issues: A Bimonthly Report from ARL, CNI, and SPARC. RLI 262

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2009-01-01

This issue of "Research Library Issues" includes the following articles: (1) The University's Role in the Dissemination of Research and Scholarship--A Call to Action; (2) ARL Statement to Scholarly Publishers on the Global Economic Crisis (Karla Hahn); (3) Reinventing Science Librarianship: Themes from the ARL-CNI Forum (Elisabeth Jones); and (4)…

The ARL 2030 Scenarios: A User's Guide for Research Libraries

ERIC Educational Resources Information Center

Association of Research Libraries, 2010

2010-01-01

This user's guide was developed to advance local planning at ARL member libraries. It is written for library leaders writ large and for anyone leading or contributing to research library planning processes. Users do not need advanced facilitation skills to benefit from this guide, but facilitators charged with supporting scenario planning will…

ARL Academic Health Sciences Library Statistics 2006-2007

ERIC Educational Resources Information Center

Kyrillidou, Martha, Comp.; Bland, Les, Comp.

2008-01-01

This document presents data that describe collections, expenditures, personnel, and services in 65 medical libraries at Association of Research Libraries (ARL) member institutions throughout North America. In 2006-2007, the reporting health sciences libraries held a median of 244,188 volumes, spent a total of $244,188,020, and employed 2,395 FTE…

National Libraries' Leadership Roles and Responsibilities. Minutes of the Semiannual Meeting of the Association of Research Libraries (115th, Bethesda, Maryland, October 18-20, 1989).

ERIC Educational Resources Information Center

Harvey, Diane, Ed.

This membership meeting of the Association of Research Libraries (ARL) opened with an overview of the challenges facing research libraries and the relationships between the three U.S. national libraries and the members of ARL by Sidney Verba of Harvard University. The directors of the national libraries then spoke on their current programs and…

Safeguarding Collections at the Dawn of the 21st Century: Describing Roles & Measuring Contemporary Preservation Activities in ARL Libraries

ERIC Educational Resources Information Center

Meyer, Lars

2009-01-01

Preservation has long been considered a fundamental responsibility of research libraries. Data on preservation activities by its members has been collected by the Association of Research Libraries (ARL) since 1987, but changing digital technologies and the research, teaching, and learning environments in which research libraries are engaged…

Research Library Issues: A Quarterly Report from ARL, CNI, and SPARC. RLI 278

ERIC Educational Resources Information Center

Baughman, M. Sue, Ed.

2012-01-01

"Research Library Issues" ("RLI") is a quarterly report from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). This issue includes the following articles: (1) Leading a Full Life: Reflections on Several Decades of Work, Family,…

Research Library Issues: A Quarterly Report from ARL, CNI, and SPARC. RLI 277

ERIC Educational Resources Information Center

Baughman, M. Sue, Ed.

2011-01-01

"Research Library Issues" ("RLI") is a quarterly report from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). This issue includes the following articles: (1) Rebalancing the Investment in Collections (H. Thomas Hickerson); (2)…

Resource Notebook on Staff Development.

ERIC Educational Resources Information Center

Sitts, Maxine K., Ed.

Based on the comprehensive library self-study method developed by the Association of Research Libraries' (ARL) Office of Management Studies (OMS) and first used as the Management Review and Analysis Project (MRAP), this resource notebook presents surveys and diagnostic aids, OMS self-study reports, and ARL member library documents related to…

Research Library Issues: A Bimonthly Report from ARL, CNI, and SPARC. RLI 269

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2010-01-01

"Research Library Issues" ("RLI") is a bimonthly report from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). This issue includes the following articles: (1) Strategies for Opening Up Content: Laying the Groundwork for an Open…

Research Library Issues: A Quarterly Report from ARL, CNI, and SPARC. RLI 279

ERIC Educational Resources Information Center

Baughman, M. Sue, Ed.

2012-01-01

"Research Library Issues" ("RLI") is a quarterly report from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). This issue includes the following articles: (1) Digitization of Special Collections and Archives: Legal and Contractual Issues (Peter B.…

A Preservation Program for the Colorado State University Libraries. The Final Report of the ARL/OMS Preservation Planning Program.

ERIC Educational Resources Information Center

Green, Stephen; And Others

This final report is a product of a Preservation Planning Program (PPP) self-study conducted by the Colorado State University Library (CSUL) working with the Association of Research Libraries' (ARL) Office of Management Studies (OMS). Designed to put self-help tools into the hands of library staff responsible for developing plans and procedures…

Research Library Issues: A Bimonthly Report from ARL, CNI, and SPARC--A Special Issue on Strategies for Opening up Content. RLI 269

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2010-01-01

"Research Library Issues" ("RLI") is a bimonthly report from ARL (Association of Research Libraries), CNI (Coalition of Networked Information), and SPARC (Scholarly Publishing and Academic Resources Coalition). This issue includes the following articles: (1) Strategies for Opening Up Content: Laying the Groundwork for an Open…

The Imperative for Diversity: ARL's Progress and Role

ERIC Educational Resources Information Center

Dewey, Barbara I.

2009-01-01

The Association of Research Libraries' diversity initiatives, under the leadership of Duane Webster and member libraries, have had a visible and long-lasting influence on the makeup of academic librarianship. ARL's accomplishments and progress in advancing diversity comprise important milestones for librarianship and did not come without…

Redefining Higher Education. Proceedings of the Meeting of the Association of Research Libraries (129th, Washington, DC, October 16-18, 1996).

ERIC Educational Resources Information Center

Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

The 129th meeting of the Association of Research Libraries (ARL) focused on anticipating the future of higher education in North America and identifying responses from research libraries that will contribute to emerging agendas for change. An opening session (convened by Nancy Cline, ARL Presiding President) began the meeting. The first session,…

Renewing the ARL Agenda. Proceedings of the Annual Meeting of the Association of Research Libraries (125th, Washington, DC, October 19-21, 1994).

ERIC Educational Resources Information Center

Page, Jennifer, Ed.; Brennan, Patricia, Ed.

The 125th meeting of the Association of Research Libraries (ARL) reviewed the mission statement, goals, and objectives of the Association. Major themes from the review process included the effect of technology on access and preservation; the critical need to develop measures of library effectiveness and performance; and the importance of…

Library Systems Office Organization. SPEC Kit and SPEC Flyer 211.

ERIC Educational Resources Information Center

Muir, Scott P., Comp.

The roles and responsibilities of the library systems officer continues to change as libraries move beyond the automation of library functions to offering resources in electronic formats and electronic access to information about collections beyond the walls of the home institution. This survey was designed to collect data and document some of the…

Cheerleader, Opportunity Seeker, and Master Strategist: ARL Directors as Entrepreneurial Leaders

ERIC Educational Resources Information Center

Carpenter, Maria Taesil Hudson

2012-01-01

This study explores how directors of libraries with membership in the Association of Research Libraries (ARL), who are engaged in entrepreneurial leadership, define and view it. Through structured interviews and analysis of supporting documents, it examines how entrepreneurial leadership can be used as a means for creating new organizational…

ARL: A Bimonthly Newsletter of Research Library Issues and Actions, 2001.

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2001-01-01

This document consists of six issues of the ARL (Association of Research Libraries) Newsletter, covering the year 2001. Each issue of the newsletter includes some or all of the following sections: "Current Issues," reports from the Office of Scholarly Communication, Office for Management Services, and Coalition for Networked Information,…

A Bimonthly Report on Research Library Issues and Actions from ARL, CNI, and SPARC, 2000.

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

2000-01-01

This document consists of the five issues of the bimonthly ARL (Association of Research Libraries) newsletter which cover the year 2000. Each issue includes some or all of the following sections: "Current Issues"; reports from SPARC (Scholarly Publishing and Academic Resources Coalition), Coalition for Networked Information, Office of…

Copyright Policy and Practice in Electronic Reserves among ARL Libraries

ERIC Educational Resources Information Center

Hansen, David R.; Cross, William M.; Edwards, Phillip M.

2013-01-01

This paper presents the results of a survey of 110 ARL institutions regarding their copyright policies for providing electronic reserves. It compiles descriptive statistics on library practice as well as coding responses to reveal trends and shared practices. Finally, it presents conclusions about policy making, decision making and risk aversion…

Library Reorganization & Restructuring. SPEC Kit 215.

ERIC Educational Resources Information Center

Eustis, Joanne D., Comp.; Kenney, Donald J. Comp.

As the entity traditionally responsible for serving the information needs of the university, research libraries have little choice but to change dramatically in the next 25 years. This SPEC Survey on library reorganization seeks to understand how librarians have sought to meet this challenge through the redesigning of their organization.…

Duane Webster, Assessment Pioneer

ERIC Educational Resources Information Center

Franklin, Brinley

2009-01-01

Duane Webster oversaw the Association of Research Libraries' (ARL) Statistics and Measurement Program as it evolved into the Statistics and Assessment Program. During his 20-year tenure as ARL's executive director, Duane was instrumental in the creation of ARL's Web-based Interactive Statistics and played a leadership role in the development of a…

Perspectives on...Special Collections at ARL Libraries and K-12 Outreach: Current Trends

ERIC Educational Resources Information Center

Visser, Michelle

2006-01-01

This article examines the results of a survey sent to Association of Research Libraries (ARL) Special Collections requesting information on outreach to K-12 students. Over half of the respondents work with K-12 and many of those who currently do not are planning to. New pressures and changing philosophies contribute to this trend.

ARL: A Bimonthly Newsletter of Research Library Issues and Actions, 1996.

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

1996-01-01

This document contains 6 issues (one year) of a newsletter devoted to information and reports on issues and actions of interest to research libraries. Each issue contains articles on current issues, federal relations, ARL activities, and a calendar of events, as well as columns by the Coalition for Networked Information and the Office of…

ARL: A Bimonthly Newsletter of Research Library Issues and Actions, Nos. 190-195. February-December 1997.

ERIC Educational Resources Information Center

Barrett, G. Jaia, Ed.

This document consists of six issues of the ARL (Association of Research Libraries) Newsletter, covering the year 1997. Each issue of the newsletter includes some or all of the following sections: "Current Issues," reports from the Office of Scholarly Communication, Office for Management Services, and Coalition for Networked Information,…

Interlibrary Loan Trends: Staffing and Organization. SPEC Kit #187.

ERIC Educational Resources Information Center

Dearie, Tammie Nickelson, Comp.; Steel, Virginia, Comp.

Topics related to research library interlibrary loan staffing and organizational structures were explored through a survey conducted by the Systems and Procedures Exchange Center (SPEC) of the Association of Research Libraries. Data gathered from 82 libraries show a very small increase in the number of full-time equivalents in loan units between…

AAU and ARL: The Role of Partnerships and Collective Advocacy in Policy Development

ERIC Educational Resources Information Center

Vaughn, John C.

2009-01-01

This paper briefly describes the structure of the national higher education association community, discusses the role of coalitions in collective advocacy, and reviews collaborations between the Association of American Universities (AAU) and the Association of Research Libraries (ARL) carried out during the tenure of ARL Executive Director Duane…

Special Collections in ARL Libraries: A Discussion Report from the ARL Working Group on Special Collections

ERIC Educational Resources Information Center

Association of Research Libraries, 2009

2009-01-01

This discussion report identifies key issues in the management of special collections material in the 21st century. The report uses a broad definition of "special collections," which encompasses distinctive material in all media and attendant library services. The group's main focus was on 19th- and 20th-century materials, including…

ARL: Setting the Agenda for the 1990s. Minutes of the [Membership] Meeting (112th, Oakland, California, May 5-6, 1988).

ERIC Educational Resources Information Center

Daval, Nicola, Ed.

The first of two program sessions at this semiannual meeting addressed the agenda of the Association of Research Libraries (ARL) for the 1990s, and the report provides summaries of remarks by Elaine Sloan on the background; D. Kaye Gapen on a report from the Task Force on Review of the ARL Five-Year Plan; and Duane E. Webster on the ARL framework…

Preservation of Digital Information. Proceedings of the Membership Meeting of the Association of Research Libraries (131st, Washington, DC, October 15-17, 1997).

ERIC Educational Resources Information Center

Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

The 131st meeting of the Association of Research Libraries (ARL) focused on preservation of digital information. The ARL Preservation Committee convened three panels of experts to highlight major issues raised by the archiving of digital resources, and to encourage discussion about options for operating models and criteria for digital archives.…

Teaching Outside the Box: ARL Librarians' Integration of the "One- Box" into Student Instruction

ERIC Educational Resources Information Center

Kulp, Christina; McCain, Cheryl; Scrivener, Laurie

2014-01-01

This article reports the results of a survey that targeted reference and instruction librarians who work at libraries that are members of the Asso- ciation of Research Libraries (ARL). Respondents were asked to indicate whether or not they teach students to use the one-box tool, and why or why not. Based on the responses of the 352 librarians who…

Consortial Leadership: Cooperation in a Competitive Environment. Proceedings of the Meeting of the Association of Research Libraries (130th, Albuquerque, NM, May 14-16, 1997).

ERIC Educational Resources Information Center

Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

The program of the 130th meeting of the Association of Research Libraries (ARL) explored the leadership challenges posed by the juxtapositions of cooperation and competing priorities in a consortial environment. Following an opening and welcome (Gloria Werner, ARL Presiding President), and a Keynote Address, "Defining Successful…

Qualitative Collection Analysis: The Conspectus Methodology. SPEC Kit 151.

ERIC Educational Resources Information Center

Jakubs, Deborah

The introduction to this Systems and Procedures Exchange Center (SPEC) kit explains the Conspectus method, which was developed in 1980 by the Research Libraries Group (RLG) as a means of systematically and qualitatively evaluating large library collections. The discussion considers advantages and disadvantages of this tool, which evaluates past…

Serials Control and Deselection Projects. SPEC Kit 147.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This Systems and Procedures Exchange Center (SPEC) Kit on serials control and deselection projects provides a timely review of the efforts of research libraries to control the increasing costs of serial subscriptions. This kit contains documents from 13 libraries: University of California at Los Angeles and Riverside; Universities of Florida,…

The Emerging Information Infrastructure: Players, Issues, Technology, and Strategies. Proceedings of Part I of the Meeting of the Association of Research Libraries (123rd, Arlington, Virginia, October 20-22, 1993).

ERIC Educational Resources Information Center

Mogge, Dru, Ed.; And Others

The topic of the 123rd meeting of the Association of Research Libraries (ARL) is the information infrastructure. The ARL is seeking to influence the policies that will form the backbone of the emerging information infrastructure. The first session concentrated on government roles and initiatives and included the following papers: "Opening…

Transforming Libraries: Issues and Innovations in Preserving Digital Information. SPEC Kit 228 and SPEC Flyer 228. Issue Number 5.

ERIC Educational Resources Information Center

Soete, George J.

The problem of preserving digital information and the strategies that are and might be employed to address it are the focus of this fifth issue of "Transforming Libraries." Twenty-one individuals involved at the technical or policy level in developing strategies for preserving digital information were interviewed. There is consensus on a…

A Salute to a Leader: ARL's Assessment Protocol Initiatives

ERIC Educational Resources Information Center

Heath, Fred

2009-01-01

This brief salute to Duane Webster and his defining role over the past several decades at the Association of Research Libraries (ARL) focuses on his formative role in defining and evolving the assessment protocols employed by both the association and the profession. (Contains 8 notes.)

The Automation Inventory of Research Libraries, 1989.

ERIC Educational Resources Information Center

Fayen, Emily Gallup

This inventory provides profiles, tables, and listings describing automated library activities at 103 Association of Research Libraries (ARL) institutions. The inventory includes analyses of aggregate information from individual library profiles which are then divided into three categories that reflect primarily bibliographic functions: (1)…

The Political Climate for Higher Education during Duane Webster's ARL Tenure

ERIC Educational Resources Information Center

Shulenburger, David

2009-01-01

During the period in which Duane Webster led the Association for Research Libraries (ARL), powerful commercial interests sought for their own financial purposes the information resources essential for providing education and performing research. Juxtaposed was the Internet with its inherent capacity to democratizing these resources. Commercial…

Defining Usability: How Library Practice Differs from Published Research

ERIC Educational Resources Information Center

Chen, Yu-Hui; Germain, Carol Anne; Rorissa, Abebe

2011-01-01

Library/information science professionals need a clearly articulated definition of usability/Web usability to implement intuitive websites. In this study, the authors analyzed usability definitions provided by the ARL library professionals and those found in the library/information science and computer science-information systems literature.…

Scholarly Communication: ARL as a Catalyst for Change

ERIC Educational Resources Information Center

Case, Mary M.

2009-01-01

With the creation of the Office of Scholarly Communication (OSC) in 1990, the Association of Research Libraries (ARL) launched an initiative to focus widespread attention on the dysfunctions in the scholarly publishing system. Through the collection and dissemination of data documenting the serials crisis, a bias for action that led to the…

The Coalition for Networked Information and the Rewards of Risk Taking

ERIC Educational Resources Information Center

West, Richard P.

2009-01-01

The Coalition for Networked Information (CNI) enabled the Association of Research Libraries (ARL) to develop increased visibility among leaders shaping the development of the Internet. It also provided a mechanism for ARL member institutions and others to engage in partnership strategies to develop projects that would bring digital content and…

ARL Physics Web Pages: An Evaluation by Established, Transitional and Emerging Benchmarks.

ERIC Educational Resources Information Center

Duffy, Jane C.

2002-01-01

Provides an overview of characteristics among Association of Research Libraries (ARL) physics Web pages. Examines current academic Web literature and from that develops six benchmarks to measure physics Web pages: ease of navigation; logic of presentation; representation of all forms of information; engagement of the discipline; interactivity of…

Salary Compression: A Time-Series Ratio Analysis of ARL Position Classifications

ERIC Educational Resources Information Center

Seaman, Scott

2007-01-01

Although salary compression has previously been identified in such professional schools as engineering, business, and computer science, there is now evidence of salary compression among Association of Research Libraries members. Using salary data from the "ARL Annual Salary Survey", this study analyzes average annual salaries from 1994-1995…

The ARL Scholars Portal Initiative.

ERIC Educational Resources Information Center

Jackson, Mary E.

2002-01-01

Describes an initiative of the Association of Research Libraries (ARL), the Scholars Portal Initiative, a three-year collaborative effort which seeks to provide tools for an academic community to have a single point of access on the Web to find high-quality information resources and to deliver the information and related services directly to the…

Adoption of Web 2.0 in US Academic Libraries: A Survey of ARL Library Websites

ERIC Educational Resources Information Center

Mahmood, Khalid; Richardson, John V., Jr.

2011-01-01

Purpose: This paper aims to survey the web sites of the academic libraries of the Association of Research Libraries (USA) regarding the adoption of Web 2.0 technologies. Design/methodology/approach: The websites of 100 member academic libraries of the Association of Research Libraries (USA) were surveyed. Findings: All libraries were found to be…

Book Storage in Academic Libraries. A Report Submitted to the Council on Library Resources.

ERIC Educational Resources Information Center

Piternick, George

A study was made to determine the present state of book storage in large North American academic libraries. A letter was sent to every academic library in the Association of Research Libraries (ARL) to inquire if they engaged in book storage. From the 35 which answered affirmatively, 15 were selected for visitation: the libraries of the…

A Data Acquisition Parallel Bus for Wind Tunnels at ARL (Aeronautical Research Laboratory).

DTIC Science & Technology

1989-08-01

I’TV F.E AROPY62 ARL-FLIGHT-MECH-TM-412 AR-005-629 NN 0 ( N1 DEPARTMENT OF DEFENCE I DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION AERONAUTICAL RESEARCH...Library SPARES (10 copies) TOTAL (73 copies) AL~ 140 DEPRTENT OF DEEC P-AGE CLASSIFICATION DOCUMENT CONTROL DATA UNCLASSIFIED PRIVACY MARING 1.. AR

Academic Library Web Sites: Current Practice and Future Directions

ERIC Educational Resources Information Center

Detlor, Brian; Lewis, Vivian

2006-01-01

To address competitive threats, academic libraries are encouraged to build robust Web sites personalized to learning and research tasks. Through an evaluation of Association of Research Libraries (ARL)-member Web sites, we suggest how library Web sites should evolve and reflect upon the impacts such recommendations may have on academic libraries…

Library Performance Measurement in the UK and Ireland

ERIC Educational Resources Information Center

Stanley, Tracey; Killick, Selena

2009-01-01

This survey was a joint initiative between Society of College, National, and University Libraries (SCONUL) and the Association of Research Libraries (ARL), that since 2004 has sponsored a program to assist libraries with the assessment of services that they offer their users and the processes that support those services. It was based on an ARL…

Recommendations for Benchmarking Web Site Usage among Academic Libraries.

ERIC Educational Resources Information Center

Hightower, Christy; Sih, Julie; Tilghman, Adam

1998-01-01

To help library directors and Web developers create a benchmarking program to compare statistics of academic Web sites, the authors analyzed the Web server log files of 14 university science and engineering libraries. Recommends a centralized voluntary reporting structure coordinated by the Association of Research Libraries (ARL) and a method for…

Off-Site Storage and Special Collections: A Study in Use and Impact in ARL Libraries in the United States

ERIC Educational Resources Information Center

Priddle, Charlotte; McCann, Laura

2015-01-01

Special collections libraries collect and preserve materials of intellectual and cultural heritage, providing access to unique research resources. As their holdings continue to expand, special collections in research libraries confront increased space pressures. Off-site storage facilities, used frequently by research libraries for general…

Visibility of Diversity within Association of Research Libraries Websites

ERIC Educational Resources Information Center

Mestre, Lori S.

2011-01-01

Libraries in the United States have worked towards developing more inclusive environments and programs. This inclusiveness should also extend to the online library presence. This article provides results of a web page scan of all Association of Research Libraries (ARL) in the United States to document the visibility of diversity on their pages. A…

Research Library Issues: A Report from ARL, CNI, and SPARC. RLI 283

ERIC Educational Resources Information Center

Baughman, M. Sue, Ed.

2013-01-01

"Research Library Issues" ("RLI") focuses on current and emerging topics that are strategically important to research libraries. The articles explore issues, share information, pose critical questions, and provide examples. This issue includes the following articles: (1) Special at the Core: Aligning, Integrating, and…

Usability Definitions in a Dynamically Changing Information Environment

ERIC Educational Resources Information Center

Chen, Yu-Hui; Rorissa, Abebe; Germain, Carol Anne

2015-01-01

The authors compared Web usability definitions, collected from library professionals at academic institutions of the Association of Research Libraries (ARL) through online surveys in 2007 and 2012, to determine whether library practitioners' perspectives had altered as information technologies evolved during this time. The authors applied three…

Comparing Service Priorities between Staff and Users in Association of Research Libraries (ARL) Member Libraries

ERIC Educational Resources Information Center

Jaggars, Damon E.; Jaggars, Shanna Smith; Duffy, Jocelyn S.

2009-01-01

Using the results for participating Association of Research Libraries from the 2006 LibQUAL+[R] library service quality survey, we examine the service priorities of library staff (for example, whether desired scores for each survey item are above or below average) and the extent to which they are aligned with the priorities of undergraduates,…

VizieR Online Data Catalog: A library of high-S/N optical spectra of FGKM stars (Yee+, 2017)

NASA Astrophysics Data System (ADS)

Yee, S. W.; Petigura, E. A.; von Braun, K.

2017-09-01

Classification of stars, by comparing their optical spectra to a few dozen spectral standards, has been a workhorse of observational astronomy for more than a century. Here, we extend this technique by compiling a library of optical spectra of 404 touchstone stars observed with Keck/HIRES by the California Planet Search. The spectra have high resolution (R~60000), high signal-to-noise ratio (S/N~150/pixel), and are registered onto a common wavelength scale. The library stars have properties derived from interferometry, asteroseismology, LTE spectral synthesis, and spectrophotometry. To address a lack of well-characterized late-K dwarfs in the literature, we measure stellar radii and temperatures for 23 nearby K dwarfs, using modeling of the spectral energy distribution and Gaia parallaxes. This library represents a uniform data set spanning the spectral types ~M5-F1 (Teff~3000-7000K, R*~0.1-16R{Sun}). We also present "Empirical SpecMatch" (SpecMatch-Emp), a tool for parameterizing unknown spectra by comparing them against our spectral library. For FGKM stars, SpecMatch-Emp achieves accuracies of 100K in effective temperature (Teff), 15% in stellar radius (R*), and 0.09dex in metallicity ([Fe/H]). Because the code relies on empirical spectra it performs particularly well for stars ~K4 and later, which are challenging to model with existing spectral synthesizers, reaching accuracies of 70K in Teff, 10% in R*, and 0.12dex in [Fe/H]. We also validate the performance of SpecMatch-Emp, finding it to be robust at lower spectral resolution and S/N, enabling the characterization of faint late-type stars. Both the library and stellar characterization code are publicly available. (2 data files).

Precision Stellar Characterization of FGKM Stars using an Empirical Spectral Library

NASA Astrophysics Data System (ADS)

Yee, Samuel W.; Petigura, Erik A.; von Braun, Kaspar

2017-02-01

Classification of stars, by comparing their optical spectra to a few dozen spectral standards, has been a workhorse of observational astronomy for more than a century. Here, we extend this technique by compiling a library of optical spectra of 404 touchstone stars observed with Keck/HIRES by the California Planet Search. The spectra have high resolution (R ≈ 60,000), high signal-to-noise ratio (S/N ≈ 150/pixel), and are registered onto a common wavelength scale. The library stars have properties derived from interferometry, asteroseismology, LTE spectral synthesis, and spectrophotometry. To address a lack of well-characterized late-K dwarfs in the literature, we measure stellar radii and temperatures for 23 nearby K dwarfs, using modeling of the spectral energy distribution and Gaia parallaxes. This library represents a uniform data set spanning the spectral types ˜M5-F1 (T eff ≈ 3000-7000 K, R ⋆ ≈ 0.1-16 R ⊙). We also present “Empirical SpecMatch” (SpecMatch-Emp), a tool for parameterizing unknown spectra by comparing them against our spectral library. For FGKM stars, SpecMatch-Emp achieves accuracies of 100 K in effective temperature (T eff), 15% in stellar radius (R ⋆), and 0.09 dex in metallicity ([Fe/H]). Because the code relies on empirical spectra it performs particularly well for stars ˜K4 and later, which are challenging to model with existing spectral synthesizers, reaching accuracies of 70 K in T eff, 10% in R ⋆, and 0.12 dex in [Fe/H]. We also validate the performance of SpecMatch-Emp, finding it to be robust at lower spectral resolution and S/N, enabling the characterization of faint late-type stars. Both the library and stellar characterization code are publicly available.

An Analysis of Academic Research Libraries Assessment Data: A Look at Professional Models and Benchmarking Data

ERIC Educational Resources Information Center

Lewin, Heather S.; Passonneau, Sarah M.

2012-01-01

This research provides the first review of publicly available assessment information found on Association of Research Libraries (ARL) members' websites. After providing an overarching review of benchmarking assessment data, and of professionally recommended assessment models, this paper examines if libraries contextualized their assessment…

ARL Statement on Unlimited Use and Exchange of Bibliographic Records.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC.

The Association of Research Libraries is fully committed to the principle of unrestricted access to and dissemination of ideas, i.e., member libraries must have unlimited access to the machine-readable bibliographic records which are created by member libraries and maintained in bibliographic utilities. Coordinated collection development programs…

Multicultural E-Resources: An Exploratory Study of Resources Held by ARL Libraries

ERIC Educational Resources Information Center

Maxey-Harris, Charlene

2010-01-01

The purpose of this study was to discover what libraries belonging to the Association of Research Libraries are subscribing to in support of multicultural and diversity research. A list of bibliographic and digital collections was created and searched for in the online public access catalogs of academic and research libraries in 2005 and 2008. A…

Panel Discussion on Libraries and Best Practices in Fair Use

ERIC Educational Resources Information Center

Rathemacher, Andree J.

2012-01-01

This report covers a panel discussion on the Code of Best Practices in Fair Use for Academic and Research Libraries, published in January 2012 by the Association of Research Libraries (ARL). The panel was held at the Massachusetts Institute of Technology (MIT) on March 23, 2012, and was hosted by the MIT Libraries. Panelists were Patricia…

Organizational Futures: Staffing Research Libraries in the 1990s. Minutes of the [Semiannual] Meeting of the Association of Research Libraries (105th, Washington, D.C., October 24-25, 1984).

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC.

Program presentations on issues related to staffing considerations in research libraries and business meeting minutes are combined in this report from the Association of Research Libraries (ARL). Under the program title, "Organizational Futures: Staffing Research Libraries in the 1990's," a report by the Task Force on Research Library Staffing…

Preservation: A Research Library Priority for the 1990s. Minutes of the Meeting of the Association of Research Libraries (111th, Washington, D.C., October 21-22, 1987).

ERIC Educational Resources Information Center

Daval, Nicola, Ed.; Merrill-Oldham, Jan, Ed.

These minutes of the October 1987 ARL (Association of Research Libraries) membership meeting include the following papers on preservation in the research library: (1) "A Challenge for Research Libraries" (David C. Weber); (2) "The Moral Imperative of Conservation" (James H. Billington); (3) "The Role of the Library…

Relationship of Technology and Characteristics of Library Functional Units.

ERIC Educational Resources Information Center

Lynch, Beverly P.; Verdin, Jo Ann

The project summarized in this report collected data from 3 of the 25 largest Association of Research Library (ARL) member libraries in order to: (1) examine the durability of the measure of technology set forth in "An Empirical Assessment of Perrow's Technology Construct" (Administrative Science Quarterly, 1974, pp. 338-356); (2) study…

Subject Liaisons in Academic Libraries: An Open Access Data Set from 2015

ERIC Educational Resources Information Center

Nero, Neil; Langley, Anne

2017-01-01

The work of subject liaison librarians in academic libraries has morphed to include a variety of roles that reach beyond the traditional. This study captures responses of 1,808 participants from land-grant, Oberlin Group, and Association of Research Libraries (ARL) institutions to a questionnaire about subject liaison librarians. The questionnaire…

Preservation Planning Project Study Team. Final Report.

ERIC Educational Resources Information Center

Pittsburgh Univ., PA. Libraries.

This final report is a product of a comprehensive 14-month Preservation Planning Program (PPP) self-study conducted by the University of Pittsburgh Libraries, working with the Association of Research Libraries' (ARL) Office of Management Studies. The PPP is designed to put self-help tools into the hands of library staff responsible for developing…

Measures for Electronic Resources (E-Metrics). Complete Set.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC.

The Association of Research Libraries (ARL) E-Metrics study was designed as an 18-month project in three phases: an inventory of what libraries were already doing about data collection for electronic resources and an identification of any libraries that could provide best practice; identifying and testing data elements that could be collected and…

Duane Webster's Contribution to Organization Development in Academic and Research Libraries

ERIC Educational Resources Information Center

Sullivan, Maureen

2009-01-01

Duane Webster is a visionary leader who, throughout his career, has had a significant impact on the improvement of libraries and librarianship. His work to establish the Association of Research Library's (ARL) Office of Management Studies (OMS) and its several organizational improvement programs laid the foundation for organization development in…

Unwrapping the Bundle: An Examination of Research Libraries and the "Big Deal"

ERIC Educational Resources Information Center

Strieb, Karla L.; Blixrud, Julia C.

2014-01-01

This study presents and analyzes the findings of a 2012 survey of member libraries belonging to the Association of Research Libraries (ARL) about publishers' large journal bundles and compares the results to earlier surveys. The data illuminate five research questions: market penetration, journal bundle construction, collection format shifts,…

Psychometric Properties of Scores from the Web-based LibQUAL+ Study of Perceptions of Library Service Quality.

ERIC Educational Resources Information Center

Cook, Colleen; Thompson, Bruce

2001-01-01

Investigated the psychometric integrity of scores from the LibQUAL+ evaluation of perceived library service quality conducted by ARL (Association of Research Libraries). Examines score structure, score reliability, score correlation and concurrent validity coefficients, scale means, and scale standardized norms, and considers the potential of the…

Research Library Issues: A Report from ARL, CNI, and SPARC. Special Issue on Copyright. RLI 285

ERIC Educational Resources Information Center

Baughman, M. Sue, Ed.

2015-01-01

"Research Library Issues" ("RLI") focuses on current and emerging topics that are strategically important to research libraries. The articles explore issues, share information, pose critical questions, and provide examples. This issue includes the following articles: (1) Special Issue on Copyright (Prudence S. Adler); (2) Fair…

The Advent of Portals.

ERIC Educational Resources Information Center

Jackson, Mary E.

2002-01-01

Explains portals as tools that gather a variety of electronic information resources, including local library resources, into a single Web page. Highlights include cross-database searching; integration with university portals and course management software; the ARL (Association of Research Libraries) Scholars Portal Initiative; and selected vendors…

Racial and Ethnic Diversity in Academic Library Collections: Ownership and Access of African American and U.S. Latino Periodical Literature.

ERIC Educational Resources Information Center

Vega Garcia, Susan A.

2000-01-01

Measures ownership of and access to African American and Latino periodical literature, illustrating the successes and failures in promoting racial and ethnic diversity in research libraries belonging to the ARL (Association of Research Libraries). Discusses desirability of multicultural collections; bibliographic control and access issues; and…

Preservation Planning Program. Study Report. Iowa State University Library. Final Report.

ERIC Educational Resources Information Center

Galejs, John; And Others

This final report is a product of a Preservation Planning Program (PPP) self-study conducted by the Iowa State University, working with the Association of Research Libraries' (ARL) Office of Management Studies. The PPP is designed to put self-help tools into the hands of library staff responsible for developing plans and procedures for preserving…

Changing Patterns in Internal Communication in Large Academic Libraries. Occasional Paper Number 6.

ERIC Educational Resources Information Center

Euster, Joanne R.

Based on data from a 1979 survey of ARL member libraries, this study by the Office of Management Studies analyzes the responses of selected libraries which had provided internal studies or planning documents on the subject of internal communication and notes the extent of resulting changes in procedures. The studies yielded information on staff…

Three Years and Counting--The Economic Crisis Is Still with Us

ERIC Educational Resources Information Center

Lowry, Charles B.

2011-01-01

Where library budgets are concerned, there is every evidence now, after three years, that research libraries have arrived at "the new normal." That is, they do not expect a return to systematic and regular additions to Association of Research Libraries' (ARL) budgets in order to support ever-increasing prices that are out of proportion to…

Precision Stellar Characterization of FGKM Stars using an Empirical Spectral Library

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yee, Samuel W.; Petigura, Erik A.; Von Braun, Kaspar, E-mail: syee@caltech.edu

Classification of stars, by comparing their optical spectra to a few dozen spectral standards, has been a workhorse of observational astronomy for more than a century. Here, we extend this technique by compiling a library of optical spectra of 404 touchstone stars observed with Keck/HIRES by the California Planet Search. The spectra have high resolution ( R ≈ 60,000), high signal-to-noise ratio (S/N ≈ 150/pixel), and are registered onto a common wavelength scale. The library stars have properties derived from interferometry, asteroseismology, LTE spectral synthesis, and spectrophotometry. To address a lack of well-characterized late-K dwarfs in the literature, we measuremore » stellar radii and temperatures for 23 nearby K dwarfs, using modeling of the spectral energy distribution and Gaia parallaxes. This library represents a uniform data set spanning the spectral types ∼M5–F1 ( T {sub eff} ≈ 3000–7000 K, R {sub ⋆} ≈ 0.1–16 R {sub ⊙}). We also present “Empirical SpecMatch” (SpecMatch-Emp), a tool for parameterizing unknown spectra by comparing them against our spectral library. For FGKM stars, SpecMatch-Emp achieves accuracies of 100 K in effective temperature ( T {sub eff}), 15% in stellar radius ( R {sub ⋆}), and 0.09 dex in metallicity ([Fe/H]). Because the code relies on empirical spectra it performs particularly well for stars ∼K4 and later, which are challenging to model with existing spectral synthesizers, reaching accuracies of 70 K in T {sub eff}, 10% in R {sub ⋆}, and 0.12 dex in [Fe/H]. We also validate the performance of SpecMatch-Emp, finding it to be robust at lower spectral resolution and S/N, enabling the characterization of faint late-type stars. Both the library and stellar characterization code are publicly available.« less

Research Libraries: Measurement, Management, Marketing. Minutes of the Meeting of the Association of Research Libraries (108th, Minneapolis, Minnesota, May 1-2, 1986).

ERIC Educational Resources Information Center

Daval, Nicola, Ed.

Program presentations on issues related to the use of statistics by research libraries and business meeting minutes are combined in this report from the Association of Research Libraries (ARL). The full text is provided for the three papers on the program theme that were presented at the meeting: (1) "Information to Manage--The Economics of…

Service Quality: A Concept not Fully Explored.

ERIC Educational Resources Information Center

Hernon, Peter; Nitecki, Danuta A.

2001-01-01

Examines the concept of service quality in libraries. Highlights include assessment; service quality versus user satisfaction; measuring service quality, including SERVQUAL; planning; experiences at Texas A& M University in cooperation with ARL (Association of Research Libraries) that resulted in LibQUAL+; and conceptual issues. (Contains 54…

Performance Appraisal in Research Libraries. SPEC Kit 140.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit and flyer produced by the Systems and Procedures Exchange Center of the Association of Research Libraries provides documents submitted by 14 universities that are used in the performance evaluation of professional library staff. Commentary based on a thorough review of documents submitted by 60 libraries includes an overview of the…

Open WorldCat and Its Impact on Academic Libraries

ERIC Educational Resources Information Center

El-Sherbini, Magda

2007-01-01

This paper analyzes librarians' reactions to the Open OCLC WorldCat. A detailed survey was sent to ARL libraries to explore what, if anything, the libraries are currently doing to prepare for these changes and how they plan to cope with the probability of having all their records open to the whole world. Survey findings indicate that most of the…

The Research Library's Role in Digital Repository Services: Final Report of the ARL Digital Repository Issues Task Force

ERIC Educational Resources Information Center

Association of Research Libraries, 2009

2009-01-01

Libraries are making diverse contributions to the development of many types of digital repositories, particularly those housing locally created digital content, including new digital objects or digitized versions of locally held works. In some instances, libraries are managing a repository and its related services entirely on their own, but often…

Canada, Copyright, and the Common Good

ERIC Educational Resources Information Center

Haslett, K. Mark

2009-01-01

Advocacy on public policy issues such as copyright is a common concern of the Association of Research Libraries (ARL) and the Canadian Association of Research Libraries (CARL). Duane Webster has been instrumental in facilitating a collaborative approach to such advocacy. Part of this involves concerted efforts to ensure that fair use (United…

Copyright, Public Policy, and the Scholarly Community.

ERIC Educational Resources Information Center

Matthews, Michael, Ed.; Brennan, Patricia, Ed.

At the May 1995 Membership Meeting of the Association of Research Libraries (ARL), a panel of experts offered four perspectives on strategies and public policy choices involved in defining the rights and responsibilities of copyright owners, users, and the libraries in the networked environment. These perspectives, and an additional paper…

GPU-accelerated simulations of isolated black holes

NASA Astrophysics Data System (ADS)

Lewis, Adam G. M.; Pfeiffer, Harald P.

2018-05-01

We present a port of the numerical relativity code SpEC which is capable of running on NVIDIA GPUs. Since this code must be maintained in parallel with SpEC itself, a primary design consideration is to perform as few explicit code changes as possible. We therefore rely on a hierarchy of automated porting strategies. At the highest level we use TLoops, a C++ library of our design, to automatically emit CUDA code equivalent to tensorial expressions written into C++ source using a syntax similar to analytic calculation. Next, we trace out and cache explicit matrix representations of the numerous linear transformations in the SpEC code, which allows these to be performed on the GPU using pre-existing matrix-multiplication libraries. We port the few remaining important modules by hand. In this paper we detail the specifics of our port, and present benchmarks of it simulating isolated black hole spacetimes on several generations of NVIDIA GPU.

Collections: Their Development, Management, Preservation, and Sharing. Papers from the Joint Meeting of the Association of Research Libraries and the Standing Conference of National and University Libraries (York, England, September 19-22, 1988).

ERIC Educational Resources Information Center

Daval, Nicola, Ed.

Papers from the joint meeting are assembled in this document. Each of the meeting's five program sessions featured presentations by a Standing Conference of National and Universal Libraries (SCONUL) director and an Association of Research Libraries (ARL) director. The presentations highlight perspectives from both sides of the Atlantic and are…

LibQUAL+[TM]: A Methodological Suite; Reliability and Structure of LibQUAL+[TM] Scores: Measuring Perceived Library Service Quality; Score Norms for Improving Library Service Quality: A LibQUAL+[TM] Study; ARL Index and Other Validity Correlates of LibQUAL+[TM] Scores.

ERIC Educational Resources Information Center

Heath, Fred M.; Thompson, Bruce; Cook, Colleen; Thompson, Russel L.; Kyrillidou, Martha

2002-01-01

Includes four articles that discuss LibQUAL+[TM], a collaborative effort of the Association of Research Libraries and Texas A&M University responding to the need for greater accountability in measuring the delivery of library services to research library users. Discusses the reliability of LibQUAL+[TM] scores in measuring perceived library…

Library Publications Programs. SPEC Kit 145.

ERIC Educational Resources Information Center

Knudsen, Monica L.

Based on a two-phase survey of 118 Association of Research Libraries member libraries which was conducted between November 1987 and January 1988, this report begins with an overview of the responses from 16 respondents who indicated that they had a centralized approach to publishing. Areas studied include the nature of centralized programs,…

Digitizing Technologies for Preservation. SPEC Kit 214.

ERIC Educational Resources Information Center

Kellerman, L. Suzanne, Comp.; Wilson, Rebecca, Comp.

The Association of Research Libraries distributed a survey to its 119 member libraries to assess the use of state-of-the-art digital technologies as a preservation method. Libraries were asked to report detailed data on all projects designed specifically to: (1) enhance images of faded or brittle originals, (2) provide access to digital images…

Factors in Science Journal Cancellation Projects: The Roles of Faculty Consultations and Data

ERIC Educational Resources Information Center

Williamson, Jeanine; Fernandez, Peter; Dixon, Lana

2014-01-01

The economic downturn of 2007-08 forced many academic libraries in the United States to cancel journals. We surveyed life sciences librarians from ARL libraries to find out about their experiences with journal cancellations during 2008-12. Overall, we discovered that two factors were essential in decision-making: faculty consultations and data.…

Preservation at Stony Brook. Preservation Planning Program. Study Report.

ERIC Educational Resources Information Center

Cook, Donald C.; And Others

This final report is a product of a Preservation Planning Program (PPP) self-study conducted by the State University of New York (SUNY), Stony Brook, working with the Association of Research Libraries' (ARL) Office of Management Studies (OMS). The PPP is designed to put self-help tools into the hands of library staff responsible for developing…

The Impact of Faculty Status and Gender on Employee Well-Being in Academic Libraries

ERIC Educational Resources Information Center

Galbraith, Quinn; Fry, Leanna; Garrison, Melissa

2016-01-01

This study measures job satisfaction, personal fulfillment, work/life balance, and stress levels of male and female librarians. Researchers surveyed 719 librarians at ARL institutions that either offer faculty status and tenure or offer neither. Females at libraries offering faculty status indicated poor work/life balance and high levels of stress…

Transforming Libraries: Issues and Innovations in Electronic Scholarly Publishing. Transforming Libraries Series. SPEC Kit 223.

ERIC Educational Resources Information Center

Soete, George J.

This issue covers the broad topic of electronic scholarly publication. Some 25 professionals in 20 libraries, consortia, and publishing enterprises were interviewed for this issue. A section on issues and trends for managers discusses the proliferation of roles and models; assembling the critical mass; licensing, copyright and interlibrary loan;…

E-Science and Astronomy Faculty: Past, Present, and Future

NASA Astrophysics Data System (ADS)

Pedersen, L. A.

2010-10-01

In 2003, the Association of Research Libraries (ARL) began to recognize the implications of large-scale science and distributed networks on 21st century libraries and librarianship. Its members became very aware of e-science. The National Science Foundation (NSF) had already studied developing a major focus on cyberinfrastructure. This was stimulated by the awareness of the oncoming data deluge that started with astronomical research. This paper gives an overview of the history in the United States behind the NSF and ARL push among their constituents regarding each organization's e-science concepts and goals. In the present, it describes a brief case study involving the expectations of the astronomy/astrophysics faculty at Brown University. The future role of the astronomy librarian for his/her faculty at an academic institution greatly depends on mandates, policies, and the librarian's skills of archiving and providing access.

Smoke Emission Tests on Series II and Series III Allison T56 Turboprop Engines

DTIC Science & Technology

1986-12-01

Buioary ■ (13) available to ARL of aromatic content of AVTUR from Australian sources. The US data was obtained from information contained in Sheldon...Library Flight Standards Division Statutory and State Authorities and Industry Australian Atomic Energy Commiasion, Director Australian Airlines...Ampol Petroleum (Vic) Pty Md, Lubricant Sales & Service Mgr Ansett Airlines of Australia, Library Australian Coal Industry Research Labs

Confronting the Challenges of the Digital Era. Proceedings of the Membership Meeting of the Association of Research Libraries (133rd, Washington, DC, October 14-16, 1998).

ERIC Educational Resources Information Center

Bhalla, Nicole, Ed.; Barrett, Jaia, Ed.; Wetzel, Karen A., Ed.

The 133rd meeting of the Association of Research Libraries (ARL) focused on strategies for confronting critical challenges associated with the digital era and for fostering understanding from university leaders and supporters regarding the resources needed to perform successfully in this print plus digital environment. Program Session I,…

Epsilon-Q: An Automated Analyzer Interface for Mass Spectral Library Search and Label-Free Protein Quantification.

PubMed

Cho, Jin-Young; Lee, Hyoung-Joo; Jeong, Seul-Ki; Paik, Young-Ki

2017-12-01

Mass spectrometry (MS) is a widely used proteome analysis tool for biomedical science. In an MS-based bottom-up proteomic approach to protein identification, sequence database (DB) searching has been routinely used because of its simplicity and convenience. However, searching a sequence DB with multiple variable modification options can increase processing time, false-positive errors in large and complicated MS data sets. Spectral library searching is an alternative solution, avoiding the limitations of sequence DB searching and allowing the detection of more peptides with high sensitivity. Unfortunately, this technique has less proteome coverage, resulting in limitations in the detection of novel and whole peptide sequences in biological samples. To solve these problems, we previously developed the "Combo-Spec Search" method, which uses manually multiple references and simulated spectral library searching to analyze whole proteomes in a biological sample. In this study, we have developed a new analytical interface tool called "Epsilon-Q" to enhance the functions of both the Combo-Spec Search method and label-free protein quantification. Epsilon-Q performs automatically multiple spectral library searching, class-specific false-discovery rate control, and result integration. It has a user-friendly graphical interface and demonstrates good performance in identifying and quantifying proteins by supporting standard MS data formats and spectrum-to-spectrum matching powered by SpectraST. Furthermore, when the Epsilon-Q interface is combined with the Combo-Spec search method, called the Epsilon-Q system, it shows a synergistic function by outperforming other sequence DB search engines for identifying and quantifying low-abundance proteins in biological samples. The Epsilon-Q system can be a versatile tool for comparative proteome analysis based on multiple spectral libraries and label-free quantification.

The Trending Academic Library Job Market: An Analysis of Library Position Announcements from 2011 with Comparisons to 1996 and 1988

ERIC Educational Resources Information Center

Triumph, Therese F.; Beile, Penny M.

2015-01-01

The primary objective of the study was to describe the number, types and titles, requested qualifications and skills, salary information, and locations of positions advertised in 2011 on the ALA JobLIST and ARL Job Announcements websites and in the print version of the Chronicle of Higher Education for purposes of determining the current state of…

Technology and the Future of Scholarly Exchange. Minutes of the Annual Meeting of the Association of Research Libraries (114th, Providence, Rhode Island, May 10-12, 1989).

ERIC Educational Resources Information Center

Harvey, Diane, Ed.

This membership meeting of the Association of Research Libraries (ARL) focused on the impact of the new information technologies on scholarly exchange. The program was organized into two sessions comprising 11 papers in all. In the first session, three influential leaders presented papers exploring different aspects of the conference topic. In the…

Component, Context and Manufacturing Model Library (C2M2L)

DTIC Science & Technology

2013-03-01

Penn State team were stored in a relational database for easy access, storage and maintainability. The relational database consisted of a PostGres ...file into a format that can be imported into the PostGres database. This same custom application was used to generate Microsoft Excel templates...Press Break Forming Equipment 4.14 Manufacturing Model Library Database Structure The data storage mechanism for the ARL PSU MML was a PostGres database

Faculty Publications and Citations: A Longitudinal Examination

ERIC Educational Resources Information Center

Budd, John M.

2017-01-01

This investigation seeks to study the publication and citation activity of faculty at research universities, as defined by membership in the Association of Research Libraries (ARL). It constitutes the fourth iteration in a study of publishing behaviors, conducted over more than twenty years. The present data indicate a substantial rise in…

Collection-Level Surveys for Special Collections: Coalescing Descriptors across Standards

ERIC Educational Resources Information Center

Ascher, James P.; Ferris, Anna M.

2012-01-01

Developing collection-level surveys to expose hidden collections in special collections and archives departments within ARL libraries has received a great deal of scholarly attention in the recent years. Numerous standards have been explored, and each has its strengths and weaknesses. This paper summarizes some of the major initiatives in…

Salary Compression in the Association of Research Libraries

ERIC Educational Resources Information Center

Seaman, Scott

2005-01-01

Using salary data from the "ARL Annual Salary Survey," this paper analyzes 2003-2004 salary data for evidence of salary compression. It reviews the concept of salary compression to explain its relationship to market salary rates and salary dispersion within an organization. The analysis utilizes comparison ratios between salaries and years of…

Why We Do What We Do: Exploring Priorities within Public Services Librarianship

ERIC Educational Resources Information Center

Johnson, Corey M.; Lindsay, Elizabeth Blakesley

2006-01-01

Public services librarians perform an increasingly diverse set of duties, and this study explores which job components are most important to librarians. The researchers surveyed public services librarians at ARL libraries to gather data on both intrinsic and extrinsic factors that influence how public services librarians spend their time. The…

Searching for the Formula: How Librarians Teach Chemistry Graduate Students Research Skills

ERIC Educational Resources Information Center

Fong, Bonnie L.

2014-01-01

An exploratory study was conducted in Summer 2012 in an effort to determine what librarians in the United States are doing to teach chemistry graduate students research skills. Chemistry librarians at ARL (Association of Research Libraries) institutions were surveyed about the content they teach; when, where, and how they present it; and what…

Preserving Knowledge: The Case for Alkaline Paper. ARL Briefing Package Number 3.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC.

This briefing package consists of a compilation of over 15 papers, fact sheets, and other materials focusing on the use of acid-free papers in books and other publications. The document contains the following: Executive Summary and List of Contents; Some Frequently Asked Questions; "Paper Preservation in Library Collections: Basic Information.…

Tenure Policies. SPEC Kit 9.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This collection of tenure policies in academic and research libraries contains: "Statement of Principles on Academic Freedom and Tenure Adopted by the American Association of University Professors", including the "Model Statement of Criteria and Procedures for Appointment, Promotion in Academic Rank, and Tenure for College and University…

Building phytochemical mass spec identification protocols and database libraries

USDA-ARS?s Scientific Manuscript database

An optimized single LC-MS evaluation that would accurately determine the elemental composition of as many compounds present in an extract would greatly aid in the evaluation of plant tissues. For phytochemicals, we have used accurate mass analysis to quickly characterize the potential chemical formu...

Information Technology Policies. SPEC Kit 218.

ERIC Educational Resources Information Center

Leung, Shirley; Bisom, Diane

The objectives of this survey were: to gather information on the development of institutional information technology policies and guidelines for responsible computing and use of electronic information; to identify the scope of such policies and guidelines; and to determine the role of the library in the development and/or use of the policies and…

SPECabq v. 2.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chambers, Robert S.; Neidigk, Matthew A.

Sandia SPECabq is FORTRAN code that defines the user supplied subroutines needed to perform nonlinear viscoelastic analyses in the ABAQUS commercial finite element code based on the Simplified Potential Energy Clock (SPEC) Model. The SPEC model was published in the open literature in 2009. It must be compiled and linked with the ABAQUS libraries under the user supplied subroutine option of the ABAQUS executable script. The subroutine is used to analyze the thermomechanical behavior of isotropic polymers predicting things like how a polymer may undergo stress or volume relaxation under different temperature and loading environments. This subroutine enables the ABAQUSmore » finite element code to be used for analyzing the thermo-mechanical behavior of samples and parts that are made from glassy polymers.« less

Cell Libraries

NASA Technical Reports Server (NTRS)

1994-01-01

A NASA contract led to the development of faster and more energy efficient semiconductor materials for digital integrated circuits. Gallium arsenide (GaAs) conducts electrons 4-6 times faster than silicon and uses less power at frequencies above 100-150 megahertz. However, the material is expensive, brittle, fragile and has lacked computer automated engineering tools to solve this problem. Systems & Processes Engineering Corporation (SPEC) developed a series of GaAs cell libraries for cell layout, design rule checking, logic synthesis, placement and routing, simulation and chip assembly. The system is marketed by Compare Design Automation.

PIXiE: an algorithm for automated ion mobility arrival time extraction and collision cross section calculation using global data association

PubMed Central

Ma, Jian; Casey, Cameron P.; Zheng, Xueyun; Ibrahim, Yehia M.; Wilkins, Christopher S.; Renslow, Ryan S.; Thomas, Dennis G.; Payne, Samuel H.; Monroe, Matthew E.; Smith, Richard D.; Teeguarden, Justin G.; Baker, Erin S.; Metz, Thomas O.

2017-01-01

Abstract Motivation: Drift tube ion mobility spectrometry coupled with mass spectrometry (DTIMS-MS) is increasingly implemented in high throughput omics workflows, and new informatics approaches are necessary for processing the associated data. To automatically extract arrival times for molecules measured by DTIMS at multiple electric fields and compute their associated collisional cross sections (CCS), we created the PNNL Ion Mobility Cross Section Extractor (PIXiE). The primary application presented for this algorithm is the extraction of data that can then be used to create a reference library of experimental CCS values for use in high throughput omics analyses. Results: We demonstrate the utility of this approach by automatically extracting arrival times and calculating the associated CCSs for a set of endogenous metabolites and xenobiotics. The PIXiE-generated CCS values were within error of those calculated using commercially available instrument vendor software. Availability and implementation: PIXiE is an open-source tool, freely available on Github. The documentation, source code of the software, and a GUI can be found at https://github.com/PNNL-Comp-Mass-Spec/PIXiE and the source code of the backend workflow library used by PIXiE can be found at https://github.com/PNNL-Comp-Mass-Spec/IMS-Informed-Library. Contact: erin.baker@pnnl.gov or thomas.metz@pnnl.gov Supplementary information: Supplementary data are available at Bioinformatics online. PMID:28505286

PIXiE: an algorithm for automated ion mobility arrival time extraction and collision cross section calculation using global data association.

PubMed

Ma, Jian; Casey, Cameron P; Zheng, Xueyun; Ibrahim, Yehia M; Wilkins, Christopher S; Renslow, Ryan S; Thomas, Dennis G; Payne, Samuel H; Monroe, Matthew E; Smith, Richard D; Teeguarden, Justin G; Baker, Erin S; Metz, Thomas O

2017-09-01

Drift tube ion mobility spectrometry coupled with mass spectrometry (DTIMS-MS) is increasingly implemented in high throughput omics workflows, and new informatics approaches are necessary for processing the associated data. To automatically extract arrival times for molecules measured by DTIMS at multiple electric fields and compute their associated collisional cross sections (CCS), we created the PNNL Ion Mobility Cross Section Extractor (PIXiE). The primary application presented for this algorithm is the extraction of data that can then be used to create a reference library of experimental CCS values for use in high throughput omics analyses. We demonstrate the utility of this approach by automatically extracting arrival times and calculating the associated CCSs for a set of endogenous metabolites and xenobiotics. The PIXiE-generated CCS values were within error of those calculated using commercially available instrument vendor software. PIXiE is an open-source tool, freely available on Github. The documentation, source code of the software, and a GUI can be found at https://github.com/PNNL-Comp-Mass-Spec/PIXiE and the source code of the backend workflow library used by PIXiE can be found at https://github.com/PNNL-Comp-Mass-Spec/IMS-Informed-Library . erin.baker@pnnl.gov or thomas.metz@pnnl.gov. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

Mission Critical Computer Resources Management Guide

DTIC Science & Technology

1988-09-01

Support Analyzers, Management, Generators Environments Word Workbench Processors Showroom System Structure HO Compilers IMath 1OperatingI Functions I...Simulated Automated, On-Line Generators Support Exercises Catalog, Function Environments Formal Spec Libraries Showroom System Structure I ADA Trackers I...shown in Figure 13-2. In this model, showrooms of larger more capable piecesare developed off-line for later integration and use in multiple systems

Characteristics of AVIRIS Band Measurements in Desert Agroecosystems in the Area of Blythe, California. 1; Studies of Cotton Spectra

NASA Technical Reports Server (NTRS)

Hanna, Safwat H. Shakir

2001-01-01

Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) data from Blythe, California, were acquired in June 1997 to study agricultural spectra from different crops and to identify crops in other areas with similar environmental factors and similar spectral properties. The main objectives of this study are: (1) to compare the spectral and radiometric characteristics of AVIRIS data from agriculture crops with ground spectra measured by a FieldSpec ASD spectrometer; (2) to explore the use of AVIRIS spectral images for identifying agricultural crops; (3) to study the spectral expression of environmental factors on selected crops; and (4) to build a spectral library for the crops that were studied. A long-term goal is to extend the spectral library for different vegetation or crops in different stages of growth. To support our study, on July 18 and 19, 2000, we collected spectra using the FieldSpec spectrometer from selected fields with different crops in the Blythe area of California (longitude 114 deg 33.28 W and latitude 33 deg 25.42 N to longitude 1140 44.53 W and latitude 33 deg 39.77 N). These crops were cotton in different stages of growth, varieties of grass pure or mixed, Sudan grass, Bermuda grass, Teff grass, and alfalfa. Some of the fields were treated with different types of irrigation (i.e., wet to dry conditions). Additional parameters were studied such as the soil water content (WC), pH, and organic matter (OM). The results of this study showed that for crops known to be similar, there is a significant correlation between the spectra that were collected by AVIRIS in 1997 and spectra measured by the FieldSpec (registered) spectrometer in 2000. This correlation allowed development of a spectral library to be used in ENVI-IDL analysis software. This library was used successfully to identify different crops. Furthermore, using IDL algorithms of Spectral Angle Mapper classification (SAM), spectral feature fitting (SFF) and spectral binary encoding (SPE) showed that there is excellent agreement between the predicted and the actual crop type (i.e., the correlation is between 85-90% match). Further use of the AVIRIS images can be of a value to crop identification or crop yield for commercial use.

Electrical and Thermal Effects of Rail Cladding in a Full-Scale Launcher

DTIC Science & Technology

1998-04-01

A. E. Zielinski , "Current and Heat Transport in the Cannon-Caliber Electromagnetic Gun Armature," Army Research Laboratory, ARL-MR-258, August...Laboratory AMSRL-CI-LP Technical Library 305 Aberdeen Prvg Grd, MD 21005-5066 Mr. Dave Bauer lAP Research, Incorporated 2763 Culver Avenue Dayton...TX 78759 Mr. Robert J. Taylor Lockheed Martin Vought Systems M/S: WT-21 P.O. Box 650003 Dallas, TX 75265-0003 Mr. Alex Zielinski U.S. Army

Mutations in ARL2BP, Encoding ADP-Ribosylation-Factor-Like 2 Binding Protein, Cause Autosomal-Recessive Retinitis Pigmentosa

PubMed Central

Davidson, Alice E.; Schwarz, Nele; Zelinger, Lina; Stern-Schneider, Gabriele; Shoemark, Amelia; Spitzbarth, Benjamin; Gross, Menachem; Laxer, Uri; Sosna, Jacob; Sergouniotis, Panagiotis I.; Waseem, Naushin H.; Wilson, Robert; Kahn, Richard A.; Plagnol, Vincent; Wolfrum, Uwe; Banin, Eyal; Hardcastle, Alison J.; Cheetham, Michael E.; Sharon, Dror; Webster, Andrew R.

2013-01-01

Retinitis pigmentosa (RP) is a genetically heterogeneous retinal degeneration characterized by photoreceptor death, which results in visual failure. Here, we used a combination of homozygosity mapping and exome sequencing to identify mutations in ARL2BP, which encodes an effector protein of the small GTPases ARL2 and ARL3, as causative for autosomal-recessive RP (RP66). In a family affected by RP and situs inversus, a homozygous, splice-acceptor mutation, c.101−1G>C, which alters pre-mRNA splicing of ARLBP2 in blood RNA, was identified. In another family, a homozygous c.134T>G (p.Met45Arg) mutation was identified. In the mouse retina, ARL2BP localized to the basal body and cilium-associated centriole of photoreceptors and the periciliary extension of the inner segment. Depletion of ARL2BP caused cilia shortening. Moreover, depletion of ARL2, but not ARL3, caused displacement of ARL2BP from the basal body, suggesting that ARL2 is vital for recruiting or anchoring ARL2BP at the base of the cilium. This hypothesis is supported by the finding that the p.Met45Arg amino acid substitution reduced binding to ARL2 and caused the loss of ARL2BP localization at the basal body in ciliated nasal epithelial cells. These data demonstrate a role for ARL2BP and ARL2 in primary cilia function and that this role is essential for normal photoreceptor maintenance and function. PMID:23849777

Design and Calibration of the US Army Research Laboratory (ARL) Closed Loop Laboratory Radio Frequency (RF) Propagation Section

DTIC Science & Technology

2016-10-01

ARL-TR-7860 ● OCT 2016 US Army Research Laboratory Design and Calibration of the US Army Research Laboratory (ARL) Closed Loop ...ARL-TR-7860 ● OCT 2016 US Army Research Laboratory Design and Calibration of the US Army Research Laboratory (ARL) Closed Loop Laboratory...Design and Calibration of the US Army Research Laboratory (ARL) Closed Loop Laboratory Radio Frequency (RF) Propagation Section 5a. CONTRACT NUMBER

NASA's Carbon Monitoring System (CMS) Applications and Application Readiness Levels (ARLs)-An assessment of how all CMS ARLs provide societal benefit.

NASA Astrophysics Data System (ADS)

Escobar, V. M.; Sepulveda Carlo, E.; Delgado Arias, S.

2016-12-01

During the past six years, the NASA Carbon Monitoring System (CMS) Applications effort has been engaging with stakeholders in an effort to make the 52 CMS project user friendly and policy relevant. Congressionally directed, the CMS initiative is a NASA endeavor providing carbon data products that help characterize and understand carbon sources and sinks at local and international scales. All data are freely available, and scaled for local, state, regional, national and international-level resource management. To facilitate user feedback during development, as well as understanding for the type of use and application the CMS data products can provide, the Applications project utilizes the NASA Applied Sciences Program nine step Application Readiness Level (ARL) indices. These are used to track and manage the progression and distribution of funded projects. ARLs are an adaptation of NASA's technology readiness levels (TRLs) used for managing technology and risk and reflects the three main tiers of a project: research, development and deployment. The ARLs are scaled from 1 to 9, research and development (ARL1) to operational and/or decision making ready products (ARL9). The ARLS can be broken up into three phases: Phase 1, discovery and feasibility (ARL 1-3); Phase 2, development testing and validation (ARL 4-6); and Phase 3, integration into Partner's systems (ARL 7-9). The ARLs are designed to inform both scientist and end user of the product maturity and application capability. The CMS initiative has products that range across all ARLs, providing societal benefit at multiple scales. Lower ARLs contribute to formal documents such as the IPCC while others at higher levels provide decision support quantifying the value of carbon data for greenhouse gas (GHG) reduction planning. Most CMS products have an ARL 5, (validation of a product in a relevant environment), meaning the CMS carbon science is actively in a state of science-user engagement. For the user community, ARLs are a litmus test for knowing the type of user feedback and advocacy that can be implemented into the product design. For the scientist, ARLS help communicate (1) the maturity of their science to users who would like to use it for decision making and (2) the intended use of the product.

A new variant of antimetabolic protein, arcelin from an Indian bean, Lablab purpureus (Linn.) and its effect on the stored product pest, Callosobruchus maculatus.

PubMed

Janarthanan, Sundaram; Sakthivelkumar, Shanmugavel; Veeramani, Velayutham; Radhika, Dixit; Muthukrishanan, Subbaratnam

2012-12-15

The anti-metabolic or insecticidal gene, arcelin (Arl) was isolated, cloned and sequenced using sequence specific degenerate primers from the seeds of Lablab purpureus collected from the Western Ghats, Tamil Nadu, India. The L. purpureus arcelin nucleotide sequence was homologous to Arl-3 and Arl-4 alleles from Phaseolus spp. The protein it encodes has 70% amino acid identity with the amino acid sequences of Arl-3I, Arl-3III, Arl-4 precursor, Arl-4 and Arl-4I. The partially purified arcelin from the seeds of L. purpureus using an artificial diet confirmed the complete retardation of development of the stored product pest Callosobruchus maculatus at 0.2% w/w arcelin-incorporated artificial seeds. Copyright © 2012 Elsevier Ltd. All rights reserved.

ARL Support and Analysis to the Army Public Health Command Kabul Air Quality Data Collection (Spring 2014)

DTIC Science & Technology

2016-05-01

ARL-TR-7692•MAY 2016 US Army Research Laboratory ARL Support and Analysis to the Army Public Health Command Kabul Air Quality Data Collection (Spring...return it to the originator. ARL-TR-7692•MAY 2016 US Army Research Laboratory ARL Support and Analysis to the Army Public Health Command Kabul Air Quality ...and Analysis to the Army Public Health Command Kabul Air Quality Data Collection (Spring 2014) Alan Wetmore and Thomas DeFelice ARL-TR-7692 Approved

Dysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast

PubMed Central

Benjamin, Jeremy J. R.; Poon, Pak P.; Drysdale, John D.; Wang, Xiangmin; Singer, Richard A.; Johnston, Gerald C.

2011-01-01

Small monomeric G proteins regulated in part by GTPase-activating proteins (GAPs) are molecular switches for several aspects of vesicular transport. The yeast Gcs1 protein is a dual-specificity GAP for ADP-ribosylation factor (Arf) and Arf-like (Arl)1 G proteins, and also has GAP-independent activities. The absence of Gcs1 imposes cold sensitivity for growth and endosomal transport; here we present evidence that dysregulated Arl1 may cause these impairments. We show that gene deletions affecting the Arl1 or Ypt6 vesicle-tethering pathways prevent Arl1 activation and membrane localization, and restore growth and trafficking in the absence of Gcs1. A mutant version of Gcs1 deficient for both ArfGAP and Arl1GAP activity in vitro still allows growth and endosomal transport, suggesting that the function of Gcs1 that is required for these processes is independent of GAP activity. We propose that, in the absence of this GAP-independent regulation by Gcs1, the resulting dysregulated Arl1 prevents growth and impairs endosomal transport at low temperatures. In cells with dysregulated Arl1, an increased abundance of the Arl1 effector Imh1 restores growth and trafficking, and does so through Arl1 binding. Protein sequestration at the trans-Golgi membrane by dysregulated, active Arl1 may therefore be the mechanism of inhibition. PMID:21562219

Expression of ADP-ribosylation factor (ARF)-like protein 6 during mouse embryonic development.

PubMed

Takada, Tatsuyuki; Iida, Keiko; Sasaki, Hiroshi; Taira, Masanori; Kimura, Hiroshi

2005-01-01

ADP-ribosylation factor (ARF)-like protein 6 (ARL6) is a member of the ARF-like protein (ARL) subfamily of small GTPases (Moss, 1995; Chavrier, 1999). ARLs are highly conserved through evolution and most of them possess the consensus sequence required for GTP binding and hydrolysis (Pasquallato, 2002). Among ARLs, ARL6 which was initially isolated from a J2E erythroleukemic cell line is divergent in its consensus sequences and its expression has been shown to be limited to the brain and kidney in adult mouse (Ingley, 1999). Recently, it was reported that mutations of the ARL6 gene cause type 3 Bardet-Biedl syndrome in humans and that ARL6 is involved in ciliary transport in C. elegans (Chiang, 2004; Fan, 2004). Here, we investigated the expression pattern of ARL6 during early mouse development by whole-mount in situ hybridization and found that interestingly, ARL6 mRNA was localized around the node at 7.0-7.5 days post coitum (dpc) embryos, while weak expression was also found in the ectoderm. At the later stage (8.5 dpc) ARL6 was expressed in the neural plate and probably in the somites. Based on these results, a possible role of ARL6 in early development is discussed in relation to the findings in human and C. elegans (Chiang, 2004; Fan, 2004).

Structures and Statistics of Citation Networks

DTIC Science & Technology

2011-05-01

the citations among them. The papers are in the field of high- energy physics, and they were added to the online library between 1992-2003. Each paper... energy , physics:astrophysics, mathematics, computer science, statistics and many others. The value of the setSpec field can be any of these. However...the value of the categories field might contain multiple set names listed. For instance, a paper can primarily be considered as a high- energy physics

To Stand the Test of Time: Long-Term Stewardship of Digital Data Sets in Science and Engineering. A Report to the National Science Foundation from the ARL Workshop on New Collaborative Relationships--The Role of Academic Libraries in the Digital Data Universe (Arlington, Virginia, September 26-27, 2006)

ERIC Educational Resources Information Center

Friedlander, Amy; Adler, Prudence

2006-01-01

The rapid adoption of information technology and ubiquitous networking has transformed the research and education landscape. Central to this transformation are scientific and engineering digital data collections. The life cycle management challenges associated with these intellectual assets are substantial. This is a report of a two-day workshop…

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes

PubMed Central

Marwaha, Rituraj; Arya, Subhash B.; Jagga, Divya; Kaur, Harmeet

2017-01-01

Endocytic, autophagic, and phagocytic vesicles move on microtubule tracks to fuse with lysosomes. Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to mediate this transport and fusion. However, the potential cross talk between these two GTPases is unclear. Here, we show that the Rab7 effector PLEKHM1 simultaneously binds Rab7 and Arl8b, bringing about clustering and fusion of late endosomes and lysosomes. We show that the N-terminal RUN domain of PLEKHM1 is necessary and sufficient for interaction with Arl8b and its subsequent localization to lysosomes. Notably, we also demonstrate that Arl8b mediates recruitment of HOPS complex to PLEKHM1-positive vesicle contact sites. Consequently, Arl8b binding to PLEKHM1 is required for its function in delivery and, therefore, degradation of endocytic and autophagic cargo in lysosomes. Finally, we also show that PLEKHM1 competes with SKIP for Arl8b binding, which dictates lysosome positioning. These findings suggest that Arl8b, along with its effectors, orchestrates lysosomal transport and fusion. PMID:28325809

ARL11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling.

PubMed

Arya, Subhash B; Kumar, Gaurav; Kaur, Harmeet; Kaur, Amandeep; Tuli, Amit

2018-06-22

A DP- r ibosylation factor- l ike GTPase 11 ( ARL11 ) is a cancer-predisposing gene that has remained functionally uncharacterized to date. In this study, we report that ARL11 is endogenously expressed in mouse and human macrophages and regulates their activation in response to lipopolysaccharide (LPS) stimulation. Accordingly, depletion of ARL11 impaired both LPS-stimulated pro-inflammatory cytokine production by macrophages and their ability to control intracellular replication of Salmonella. LPS-stimulated activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) was substantially compromised in Arl11 -silenced macrophages. In contrast, increased expression of ARL11 led to constitutive ERK1/2 phosphorylation, resulting in macrophage exhaustion. Finally, we found that ARL11 forms a complex with phospho-ERK in macrophages within minutes of LPS stimulation. Taken together, our findings establish ARL11 as a novel regulator of ERK signaling in macrophages, required for macrophage activation and immune function. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

A Study of the Broadband Parametric Acoustic Array

DTIC Science & Technology

1982-01-04

iJ~ exp[~~) fj 2 0 . (3.8) This expression indicates a maximum when f =--n (3.9) This result was derived by Findeisen . 64 Using the definitions of n...Interactions of Progressive Finite Amplitude Waves in Nondispersive Fluids," J. Acoust. Soc. Am. 50, 1299-1312 (1971). 64. A. G. Findeisen and S. A. Means, "A...Clynch, ARL:UT 126 George P. Coble, ARL:UT 127 Bernie R. Criswell, ARL:IJT 128 Charles R. Culbertson, ARL:UT 129 Allen G. Findeisen , ARL:UT 130 Karl C

PrIMe Next Frontier: Large, Multi-Dimensional Data Sets

DTIC Science & Technology

2015-07-21

is provided below.  3.4.2 Entities  Figure  4  is  a  diagram  that  represents  the  datatypes   of  objects/instances  that  are  used  within  the...ajax({ type: ’GET’, url: 𔃻.html’, dataType : ’text’, success: function(res) { $(’body’).append(res... dataType : ’script’, success: function() { if (++counter == libraries.length) createSpecWindow(callback

US Army Research Laboratory (ARL) Robotics Collaborative Technology Alliance 2014 Capstone Experiment

DTIC Science & Technology

2016-07-01

ARL-TR-7729 ● JULY 2016 US Army Research Laboratory US Army Research Laboratory (ARL) Robotics Collaborative Technology Alliance...TR-7729 ● JULY 2016 US Army Research Laboratory US Army Research Laboratory (ARL) Robotics Collaborative Technology Alliance 2014 Capstone...National Robotics Engineering Center, Pittsburgh, PA Robert Dean, Terence Keegan, and Chip Diberardino General Dynamics Land Systems, Westminster

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.

PubMed

Marwaha, Rituraj; Arya, Subhash B; Jagga, Divya; Kaur, Harmeet; Tuli, Amit; Sharma, Mahak

2017-04-03

Endocytic, autophagic, and phagocytic vesicles move on microtubule tracks to fuse with lysosomes. Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to mediate this transport and fusion. However, the potential cross talk between these two GTPases is unclear. Here, we show that the Rab7 effector PLEKHM1 simultaneously binds Rab7 and Arl8b, bringing about clustering and fusion of late endosomes and lysosomes. We show that the N-terminal RUN domain of PLEKHM1 is necessary and sufficient for interaction with Arl8b and its subsequent localization to lysosomes. Notably, we also demonstrate that Arl8b mediates recruitment of HOPS complex to PLEKHM1-positive vesicle contact sites. Consequently, Arl8b binding to PLEKHM1 is required for its function in delivery and, therefore, degradation of endocytic and autophagic cargo in lysosomes. Finally, we also show that PLEKHM1 competes with SKIP for Arl8b binding, which dictates lysosome positioning. These findings suggest that Arl8b, along with its effectors, orchestrates lysosomal transport and fusion. © 2017 Marwaha et al.

76 FR 18194 - Notice of Patent Application Deadline for Advanced Battery Technology Related Patents for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

...,524,579 B1). 5. ARL 04-29--Safer, Less Expensive Lithium Ion Batteries (US 7,629,080). 6. ARL 05-18... Performance by Reducing Resistance in Lithium Ion Batteries. Filed with USPTO on 2/3/2010 (S/N 12/699,182). 11.... ARL 01-37--Choosing Electrolytes for Lithium/Air Batteries (US 7,585,579). 2. ARL 02-06--Solvent...

Potential Science and Technology Game Changers for the Ground Warfare of 2050: Selected Projections Made in 2017

DTIC Science & Technology

2018-02-01

ARL-TR-8283 ● FEB 2018 US Army Research Laboratory Potential Science and Technology Game Changers for the Ground Warfare of 2050...report when it is no longer needed. Do not return it to the originator. ARL-TR-8283 ● FEB 2018 US Army Research Laboratory Potential...ARL Kwong Choi and Joseph Mait Sensors and Electron Devices Directorate, ARL Brad Forch and Shashi Karna Weapons and Materials Research

The ARG1-LIKE2 gene of Arabidopsis functions in a gravity signal transduction pathway that is genetically distinct from the PGM pathway

NASA Technical Reports Server (NTRS)

Guan, Changhui; Rosen, Elizabeth S.; Boonsirichai, Kanokporn; Poff, Kenneth L.; Masson, Patrick H.

2003-01-01

The arl2 mutants of Arabidopsis display altered root and hypocotyl gravitropism, whereas their inflorescence stems are fully gravitropic. Interestingly, mutant roots respond like the wild type to phytohormones and an inhibitor of polar auxin transport. Also, their cap columella cells accumulate starch similarly to wild-type cells, and mutant hypocotyls display strong phototropic responses to lateral light stimulation. The ARL2 gene encodes a DnaJ-like protein similar to ARG1, another protein previously implicated in gravity signal transduction in Arabidopsis seedlings. ARL2 is expressed at low levels in all organs of seedlings and plants. arl2-1 arg1-2 double mutant roots display kinetics of gravitropism similar to those of single mutants. However, double mutants carrying both arl2-1 and pgm-1 (a mutation in the starch-biosynthetic gene PHOSPHOGLUCOMUTASE) at the homozygous state display a more pronounced root gravitropic defect than the single mutants. On the other hand, seedlings with a null mutation in ARL1, a paralog of ARG1 and ARL2, behave similarly to the wild type in gravitropism and other related assays. Taken together, the results suggest that ARG1 and ARL2 function in the same gravity signal transduction pathway in the hypocotyl and root of Arabidopsis seedlings, distinct from the pathway involving PGM.

A Systematic Evaluation of the Two-Component Systems Network Reveals That ArlRS Is a Key Regulator of Catheter Colonization by Staphylococcus aureus

PubMed Central

Burgui, Saioa; Gil, Carmen; Solano, Cristina; Lasa, Iñigo; Valle, Jaione

2018-01-01

Two-component systems (TCS) are modular signal transduction pathways that allow cells to adapt to prevailing environmental conditions by modifying cellular physiology. Staphylococcus aureus has 16 TCSs to adapt to the diverse microenvironments encountered during its life cycle, including host tissues and implanted medical devices. S. aureus is particularly prone to cause infections associated to medical devices, whose surfaces coated by serum proteins constitute a particular environment. Identification of the TCSs involved in the adaptation of S. aureus to colonize and survive on the surface of implanted devices remains largely unexplored. Here, using an in vivo catheter infection model and a collection of mutants in each non-essential TCS of S. aureus, we investigated the requirement of each TCS for colonizing the implanted catheter. Among the 15 mutants in non-essential TCSs, the arl mutant exhibited the strongest deficiency in the capacity to colonize implanted catheters. Moreover, the arl mutant was the only one presenting a major deficit in PNAG production, the main exopolysaccharide of the S. aureus biofilm matrix whose synthesis is mediated by the icaADBC locus. Regulation of PNAG synthesis by ArlRS occurred through repression of IcaR, a transcriptional repressor of icaADBC operon expression. Deficiency in catheter colonization was restored when the arl mutant was complemented with the icaADBC operon. MgrA, a global transcriptional regulator downstream ArlRS that accounts for a large part of the arlRS regulon, was unable to restore PNAG expression and catheter colonization deficiency of the arlRS mutant. These findings indicate that ArlRS is the key TCS to biofilm formation on the surface of implanted catheters and that activation of PNAG exopolysaccharide production is, among the many traits controlled by the ArlRS system, a major contributor to catheter colonization. PMID:29563900

Acteonidae, Bullinidae and Ringiculidae (Gastropoda: Heterobranchia) from the Plio-Pleistocene of the Philippines.

PubMed

Helwerda, Renate A

2015-07-24

Twenty-three species of Acteonidae, Bullinidae and Ringiculidae are documented from the so-called "Cabarruyan" fauna from the Plio-Pleistocene of Pangasinan, the Philippines. There are eleven species of Acteonidae, one species of Bullinidae and eleven species of Ringiculidae. Seven species are described here as new, these are: Bathyacteon valdesi nov. spec., Bullina virgoides nov. spec., Ringicula bella nov. spec., R. circumscripta nov. spec., R. caelestis nov. spec., R. opima nov. spec. and Microglyphis angulata nov. spec.. The presence of Acteonidae and Bullinidae indicates that polychaete worms were also present.

Recurrent perseveration correlates with abnormal repetitive locomotion in adult mink but is not reduced by environmental enrichment.

PubMed

Dallaire, Jamie A; Meagher, Rebecca K; Díez-León, María; Garner, Joseph P; Mason, Georgia J

2011-10-31

We analysed the relationship between abnormal repetitive behaviour (ARB), the presence/absence of environmental enrichment, and two types of behavioural disinhibition in farmed American mink, Neovison vison. The first type, recurrent perseveration, the inappropriate repetition of already completed responses, was assessed using three indices of excessive response repetition and patterning in a bias-corrected serial two-choice guessing task. The second type, disinhibition of prepotent responses to reward cues, a form of impulsivity, was tested in a locomotive detour task adapted from primate reaching tasks: subjects were required to walk around, rather than directly into, a transparent barrier behind which food was visible. In older adult females, recurrent perseveration positively predicted pre-feeding abnormal repetitive locomotion (ARL) in Non-enriched housing. High-ARL subjects also performed repeated (same-choice) responses more rapidly than low-ARL animals, even when statistically controlling for alternated (different-choice) response latency. Mink performed much less ARL following transfer to Enriched housing, but there was no corresponding change in recurrent perseveration. Thus, elevated recurrent perseveration is not sufficient for frequent ARL; and while captive environments do determine ARL frequency, in mink, they do not necessarily do so by modifying levels of perseveration. Disinhibition of prepotent responses to reward cues, meanwhile, did not predict ARL. In a separate sample of differentially housed young adults, neither type of behavioural disinhibition predicted ARL, and again, whether or not housing was enriched did not affect behavioural disinhibition despite affecting ARL. Thus, the relationship between recurrent perseveration and ARB may only develop with age; longitudinal studies are now required for confirmation. Copyright © 2011 Elsevier B.V. All rights reserved.

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.

PubMed

Nozaki, Shohei; Katoh, Yohei; Terada, Masaya; Michisaka, Saki; Funabashi, Teruki; Takahashi, Senye; Kontani, Kenji; Nakayama, Kazuhisa

2017-02-01

ARL13B (a small GTPase) and INPP5E (a phosphoinositide 5-phosphatase) are ciliary proteins encoded by causative genes of Joubert syndrome. We here showed, by taking advantage of a visible immunoprecipitation assay, that ARL13B interacts with the IFT46 -: IFT56 (IFT56 is also known as TTC26) dimer of the intraflagellar transport (IFT)-B complex, which mediates anterograde ciliary protein trafficking. However, the ciliary localization of ARL13B was found to be independent of its interaction with IFT-B, but dependent on the ciliary-targeting sequence RVEP in its C-terminal region. ARL13B-knockout cells had shorter cilia than control cells and exhibited aberrant localization of ciliary proteins, including INPP5E. In particular, in ARL13B-knockout cells, the IFT-A and IFT-B complexes accumulated at ciliary tips, and GPR161 (a negative regulator of Hedgehog signaling) could not exit cilia in response to stimulation with Smoothened agonist. This abnormal phenotype was rescued by the exogenous expression of wild-type ARL13B, as well as by its mutant defective in the interaction with IFT-B, but not by its mutants defective in INPP5E binding or in ciliary localization. Thus, ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E. © 2017. Published by The Company of Biologists Ltd.

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes

PubMed Central

Khatter, Divya; Raina, Vivek B.; Dwivedi, Devashish; Sindhwani, Aastha; Bahl, Surbhi; Sharma, Mahak

2015-01-01

The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase Arl8b, but not Rab7 (also known as RAB7A), is essential for membrane localization of the human (h)Vps41 subunit of the HOPS complex. Assembly of the core HOPS subunits to Arl8b- and hVps41-positive lysosomes is guided by their subunit–subunit interactions. RNA interference (RNAi)-mediated depletion of hVps41 resulted in the impaired degradation of EGFR that was rescued upon expression of wild-type but not an Arl8b-binding-defective mutant of hVps41, suggesting that Arl8b-dependent lysosomal localization of hVps41 is required for its endocytic function. Furthermore, we have also identified that the Arl8b effector SKIP (also known as PLEKHM2) interacts with and recruits HOPS subunits to Arl8b and kinesin-positive peripheral lysosomes. Accordingly, RNAi-mediated depletion of SKIP impaired lysosomal trafficking and degradation of EGFR. These findings reveal that Arl8b regulates the association of the human HOPS complex with lysosomal membranes, which is crucial for the function of this tethering complex in endocytic degradation. PMID:25908847

Stanford Aerospace Research Laboratory research overview

NASA Technical Reports Server (NTRS)

Ballhaus, W. L.; Alder, L. J.; Chen, V. W.; Dickson, W. C.; Ullman, M. A.

1993-01-01

Over the last ten years, the Stanford Aerospace Robotics Laboratory (ARL) has developed a hardware facility in which a number of space robotics issues have been, and continue to be, addressed. This paper reviews two of the current ARL research areas: navigation and control of free flying space robots, and modelling and control of extremely flexible space structures. The ARL has designed and built several semi-autonomous free-flying robots that perform numerous tasks in a zero-gravity, drag-free, two-dimensional environment. It is envisioned that future generations of these robots will be part of a human-robot team, in which the robots will operate under the task-level commands of astronauts. To make this possible, the ARL has developed a graphical user interface (GUI) with an intuitive object-level motion-direction capability. Using this interface, the ARL has demonstrated autonomous navigation, intercept and capture of moving and spinning objects, object transport, multiple-robot cooperative manipulation, and simple assemblies from both free-flying and fixed bases. The ARL has also built a number of experimental test beds on which the modelling and control of flexible manipulators has been studied. Early ARL experiments in this arena demonstrated for the first time the capability to control the end-point position of both single-link and multi-link flexible manipulators using end-point sensing. Building on these accomplishments, the ARL has been able to control payloads with unknown dynamics at the end of a flexible manipulator, and to achieve high-performance control of a multi-link flexible manipulator.

Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.

PubMed

Yamamoto, Yasunori; Yoshida, Asuka; Miyazaki, Naoyuki; Iwasaki, Kenji; Sakisaka, Toshiaki

2014-02-15

The ER (endoplasmic reticulum) consists of the nuclear envelope and a peripheral network of membrane sheets and tubules. Two classes of the evolutionarily conserved ER membrane proteins, reticulons and REEPs (receptor expression-enhancing proteins)/DP1 (deleted in polyposis locus 1)/Yop1 (YIP 1 partner), shape high-curvature ER tubules. In mammals, four members of the reticulon family and six members of the REEP family have been identified so far. In the present paper we report that Arl6IP1(ADP-ribosylation factor-like 6 interacting protein 1), an anti-apoptotic protein specific to multicellular organisms, is a potential player in shaping the ER tubules in mammalian cells. Arl6IP1, which does not share an overall primary sequence homology with reticulons, harbours reticulon-like short hairpin transmembrane domains and binds to atlastin, a GTPase that mediates the formation of the tubular ER network. Overexpression of Arl6IP1 induced extensive tubular structures of the ER and excluded a luminal protein. Furthermore, overexpression of Arl6IP1 stabilized the ER tubules, allowing the cells to maintain the ER tubules even in the absence of microtubules. Arl6IP1 constricted liposomes into tubules. The short hairpin structures of the transmembrane domains were required for the membrane-shaping activity of Arl6IP1. The results of the present study indicate that Arl6IP1 has the ability to shape high-curvature ER tubules in a reticulon-like fashion.

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

PubMed

Tuli, Amit; Thiery, Jerome; James, Ashley M; Michelet, Xavier; Sharma, Mahak; Garg, Salil; Sanborn, Keri B; Orange, Jordan S; Lieberman, Judy; Brenner, Michael B

2013-12-01

Natural killer (NK) lymphocytes contain lysosome-related organelles (LROs), known as lytic granules, which upon formation of immune synapse with the target cell, polarize toward the immune synapse to deliver their contents to the target cell membrane. Here, we identify a small GTP-binding protein, ADP-ribosylation factor-like 8b (Arl8b), as a critical factor required for NK cell-mediated cytotoxicity. Our findings indicate that Arl8b drives the polarization of lytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Using a glutathione S-transferase pull-down approach, we identify kinesin family member 5B (KIF5B; the heavy chain of kinesin-1) as an interaction partner of Arl8b from NK cell lysates. Previous studies showed that interaction between kinesin-1 and Arl8b is mediated by SifA and kinesin-interacting protein (SKIP) and the tripartite complex drives the anterograde movement of lysosomes. Silencing of both KIF5B and SKIP in NK cells, similar to Arl8b, led to failure of MTOC-lytic granule polarization to the immune synapse, suggesting that Arl8b and kinesin-1 together control this critical step in NK cell cytotoxicity.

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell–mediated cytotoxicity

PubMed Central

Tuli, Amit; Thiery, Jerome; James, Ashley M.; Michelet, Xavier; Sharma, Mahak; Garg, Salil; Sanborn, Keri B.; Orange, Jordan S.; Lieberman, Judy; Brenner, Michael B.

2013-01-01

Natural killer (NK) lymphocytes contain lysosome-related organelles (LROs), known as lytic granules, which upon formation of immune synapse with the target cell, polarize toward the immune synapse to deliver their contents to the target cell membrane. Here, we identify a small GTP-binding protein, ADP-ribosylation factor-like 8b (Arl8b), as a critical factor required for NK cell–mediated cytotoxicity. Our findings indicate that Arl8b drives the polarization of lytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Using a glutathione S-transferase pull-down approach, we identify kinesin family member 5B (KIF5B; the heavy chain of kinesin-1) as an interaction partner of Arl8b from NK cell lysates. Previous studies showed that interaction between kinesin-1 and Arl8b is mediated by SifA and kinesin-interacting protein (SKIP) and the tripartite complex drives the anterograde movement of lysosomes. Silencing of both KIF5B and SKIP in NK cells, similar to Arl8b, led to failure of MTOC-lytic granule polarization to the immune synapse, suggesting that Arl8b and kinesin-1 together control this critical step in NK cell cytotoxicity. PMID:24088571

Six new species of the spider family Ochyroceratidae Fage 1912 (Arachnida: Araneae) from Southeast Asia.

PubMed

Li, Fengyuan; Li, Shuqiang; Jäger, Peter

2014-02-25

Five new Althepus species and one new Psiloderces species of the family Ochyroceratidae are described from Southeast Asia: Althepus erectus spec. nov. (male) and A. nophaseudi spec. nov. (male, female) from Laos, A. flabellaris spec. nov. (male, female) from Thailand, A. reduncus spec. nov. (male) from Myanmar, A. spiralis spec. nov. (male) from Malaysia, and Psiloderces dicellocerus spec. nov. (male) from Indonesia. Primary types are deposited in the Senckenberg Research Institute in Frankfurt, Germany (SMF).

MsSpec-1.0: A multiple scattering package for electron spectroscopies in material science

NASA Astrophysics Data System (ADS)

Sébilleau, Didier; Natoli, Calogero; Gavaza, George M.; Zhao, Haifeng; Da Pieve, Fabiana; Hatada, Keisuke

2011-12-01

We present a multiple scattering package to calculate the cross-section of various spectroscopies namely photoelectron diffraction (PED), Auger electron diffraction (AED), X-ray absorption (XAS), low-energy electron diffraction (LEED) and Auger photoelectron coincidence spectroscopy (APECS). This package is composed of three main codes, computing respectively the cluster, the potential and the cross-section. In the latter case, in order to cover a range of energies as wide as possible, three different algorithms are provided to perform the multiple scattering calculation: full matrix inversion, series expansion or correlation expansion of the multiple scattering matrix. Numerous other small Fortran codes or bash/csh shell scripts are also provided to perform specific tasks. The cross-section code is built by the user from a library of subroutines using a makefile. Program summaryProgram title: MsSpec-1.0 Catalogue identifier: AEJT_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEJT_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 504 438 No. of bytes in distributed program, including test data, etc.: 14 448 180 Distribution format: tar.gz Programming language: Fortran 77 Computer: Any Operating system: Linux, MacOs RAM: Bytes Classification: 7.2 External routines: Lapack ( http://www.netlib.org/lapack/) Nature of problem: Calculation of the cross-section of various spectroscopies. Solution method: Multiple scattering. Running time: The test runs provided only take a few seconds to run.

The Staphylococcus aureus ArlRS Two-Component System Is a Novel Regulator of Agglutination and Pathogenesis

PubMed Central

Walker, Jennifer N.; Crosby, Heidi A.; Spaulding, Adam R.; Salgado-Pabón, Wilmara; Malone, Cheryl L.; Rosenthal, Carolyn B.; Schlievert, Patrick M.; Boyd, Jeffrey M.; Horswill, Alexander R.

2013-01-01

Staphylococcus aureus is a prominent bacterial pathogen that is known to agglutinate in the presence of human plasma to form stable clumps. There is increasing evidence that agglutination aids S. aureus pathogenesis, but the mechanisms of this process remain to be fully elucidated. To better define this process, we developed both tube based and flow cytometry methods to monitor clumping in the presence of extracellular matrix proteins. We discovered that the ArlRS two-component system regulates the agglutination mechanism during exposure to human plasma or fibrinogen. Using divergent S. aureus strains, we demonstrated that arlRS mutants are unable to agglutinate, and this phenotype can be complemented. We found that the ebh gene, encoding the Giant Staphylococcal Surface Protein (GSSP), was up-regulated in an arlRS mutant. By introducing an ebh complete deletion into an arlRS mutant, agglutination was restored. To assess whether GSSP is the primary effector, a constitutive promoter was inserted upstream of the ebh gene on the chromosome in a wildtype strain, which prevented clump formation and demonstrated that GSSP has a negative impact on the agglutination mechanism. Due to the parallels of agglutination with infective endocarditis development, we assessed the phenotype of an arlRS mutant in a rabbit combined model of sepsis and endocarditis. In this model the arlRS mutant displayed a large defect in vegetation formation and pathogenesis, and this phenotype was partially restored by removing GSSP. Altogether, we have discovered that the ArlRS system controls a novel mechanism through which S. aureus regulates agglutination and pathogenesis. PMID:24367264

Heterogeneous Systems for Information-Variable Environments (HIVE)

DTIC Science & Technology

2017-05-01

ARL-TR-8027 ● May 2017 US Army Research Laboratory Heterogeneous Systems for Information - Variable Environments (HIVE) by Amar...not return it to the originator. ARL-TR-8027 ● May 2017 US Army Research Laboratory Heterogeneous Systems for Information ...Computational and Information Sciences Directorate, ARL Approved for public release; distribution is unlimited. ii REPORT

miR-214 down-regulates ARL2 and suppresses growth and invasion of cervical cancer cells.

PubMed

Peng, Ruiqing; Men, Jianlong; Ma, Rui; Wang, Qian; Wang, Yang; Sun, Ying; Ren, Jing

2017-03-11

Increasing evidence has shown that miRNAs are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. In this study, we confirmed that miR-214 is frequently down-regulated in cervical cancer compared with normal cervical tissues. Ectopic expression of miR-214 suppressed proliferation, migration and invasion of HeLa and C33A cervical cancer cells. Bioinformatics analysis revealed that ADP ribosylation factor like 2 (ARL2) was a potential target of miR-214 and was remarkably up-regulated in cervical cancer. Knockdown of ARL2 markedly inhibited cervical cancer cell proliferation, migration and invasion, similarly to over-expression of miR-214, indicating that ARL2 may function as an oncogene in cervical cancer. In conclusion, our study revealed that miR-214 acts as a tumor suppressor via inhibiting proliferation, migration and invasion of cervical cancer cells through targeting ARL2, and that both miR-214 and ARL2 may serve as prognostic or therapeutic targets for cervical cancer. Copyright © 2017 Elsevier Inc. All rights reserved.

Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 1

NASA Astrophysics Data System (ADS)

1984-08-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 4 contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the first of five books of volume four. It contains structural design criteria, generator step-up transformer specs, specs for design, fabrication and testing of the system, specs for the ground control enclosure, systems specs, slip ring specs, and control system specs.

Mod-5A Wind Turbine Generator Program Design Report. Volume 4: Drawings and Specifications, Book 1

NASA Technical Reports Server (NTRS)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 4 contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the first of five books of volume four. It contains structural design criteria, generator step-up transformer specs, specs for design, fabrication and testing of the system, specs for the ground control enclosure, systems specs, slip ring specs, and control system specs.

Cloud Migration Experiment Configuration and Results

DTIC Science & Technology

2017-12-01

ARL-TR-8248 ● DEC 2017 US Army Research Laboratory Cloud Migration Experiment Configuration and Results by Michael De Lucia...or reconstruction of the document. ARL-TR-8248 ● DEC 2017 US Army Research Laboratory Cloud Migration Experiment Configuration...and Results by Michael De Lucia Computational and Information Sciences Directorate, ARL Justin Wray and Steven S Collmann ICF International

-(S)-Alpha-phenyl-2-pyridine-ethanamine Dihydrochloride-, a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia.

PubMed

Cregan, E F; Peeling, J; Corbett, D; Buchan, A M; Saunders, J; Auer, R N; Gao, M; Mccarthy, D J; Eisman, M S; Campbell, T M; Murray, R J; Stagnitto, M L; Palmer, G C

1997-12-01

[(S)-Alpha-phenyl-2-pyridine-ethanamine dihydrochloride] (ARL 15896AR) is a low affinity uncompetitive N-methyl-D-aspartic acid receptor antagonist that was tested in animal models of anoxia and ischemia. Pretreatment of rodents with ARL 15896AR extended survival time during exposure to hypoxia. With the rat four-vessel occlusion model of global ischemia (20 min), oral dosing commencing at reflow, resulted in significant protection of the CA1 hippocampal neurons. ARL 15896AR was, however, ineffective in the rat two-vessel occlusion model and in the gerbil models of forebrain ischemia, the latter due to an inability to attain suitable plasma levels. In the spontaneously hypertensive rat model of middle cerebral artery occlusion (MCAO) (2 hr plus 22 hr reflow), acute dosing with ARL 15896AR (i.p.) beginning from 30 min before or up to 1 hr post-MCAO significantly reduced cortical infarct volume. The ability of ARL 15896AR to influence infarct size, as well as functional correlates was examined in SHR after 90 min of MCAO. T2 weighted magnetic resonance images taken at 2 and 6 days post-MCAO revealed significantly smaller lesion sizes in the group receiving injections with ARL 15896AR beginning 30 min after occlusion. Spontaneously hypertensive rats were subsequently tested (30-42 days post-MCAO) and found to be deficient in skilled use of the forepaws (staircase test). The contralateral forepaw was most severely impaired, however, ARL 15896AR treatment prevented motor impairment in only the ipsilateral forepaw. Histopathological examination of cortical infarct size was unremarkable between treated and control rats. The findings indicate that ARL 15896AR exhibits neuroprotection in global and focal models of ischemia

Four new species of pholcine spiders (Araneae: Pholcidae) from Southeast Asia.

PubMed

Yao, Zhiyuan; Li, Shuqiang; Jäger, Peter

2014-04-30

Four new species belonging to four genera of the subfamily Pholcinae are reported from Southeast Asia: Belisana protumida spec. nov. (male, female), Khorata bayeri spec. nov. (male), Pholcus schawalleri spec. nov. (male), and Uthina khaosokensis spec. nov. (male).

The Impact of Information Displays on Decision Making

DTIC Science & Technology

2017-09-01

ARL-TN-0846 ● SEP 2017 US Army Research Laboratory The Impact of Information Displays on Decision Making by John Shevlin... Information Displays on Decision Making by John Shevlin VTCC Delta Company ’19, AROTC Bravo Company Marc Jackson and Sue E Kase...Computational and Information Sciences Directorate, ARL Daniel Cassenti Human Research and Engineering Directorate, ARL Approved for public

SHERLOCK: Simple Human Experiments Regarding Locally Observed Collective Knowledge

DTIC Science & Technology

2015-12-01

ARL-RP-0560 ● DEC 2015 US Army Research Laboratory SHERLOCK: Simple Human Experiments Regarding Locally Observed Collective...report when it is no longer needed. Do not return it to the originator. ARL-RP-0560 ● DEC 2015 US Army Research Laboratory SHERLOCK... Research and Engineering Directorate, ARL Reprinted from the International Technology Alliance Collaboration System [accessed 2015 Dec 2]. https

Where Does My Augmented Reality Learning Experience (ARLE) Belong? A Student and Teacher Perspective to Positioning ARLEs

ERIC Educational Resources Information Center

Drljevic, Neven; Wong, Lung Hsiang; Boticki, Ivica

2017-01-01

The paper provides a high-level review of the current state of techno-pedagogical design in Augmented Reality Learning Experiences (ARLEs). The review is based on a rubric constructed from the Meaningful Learning with ICT framework and the Orchestration Load reduction framework, providing, respectively, a view of primarily student- and primarily…

MultiSpec: A Desktop and Online Geospatial Image Data Processing Tool

NASA Astrophysics Data System (ADS)

Biehl, L. L.; Hsu, W. K.; Maud, A. R. M.; Yeh, T. T.

2017-12-01

MultiSpec is an easy to learn and use, freeware image processing tool for interactively analyzing a broad spectrum of geospatial image data, with capabilities such as image display, unsupervised and supervised classification, feature extraction, feature enhancement, and several other functions. Originally developed for Macintosh and Windows desktop computers, it has a community of several thousand users worldwide, including researchers and educators, as a practical and robust solution for analyzing multispectral and hyperspectral remote sensing data in several different file formats. More recently MultiSpec was adapted to run in the HUBzero collaboration platform so that it can be used within a web browser, allowing new user communities to be engaged through science gateways. MultiSpec Online has also been extended to interoperate with other components (e.g., data management) in HUBzero through integration with the geospatial data building blocks (GABBs) project. This integration enables a user to directly launch MultiSpec Online from data that is stored and/or shared in a HUBzero gateway and to save output data from MultiSpec Online to hub storage, allowing data sharing and multi-step workflows without having to move data between different systems. MultiSpec has also been used in K-12 classes for which one example is the GLOBE program (www.globe.gov) and in outreach material such as that provided by the USGS (eros.usgs.gov/educational-activities). MultiSpec Online now provides teachers with another way to use MultiSpec without having to install the desktop tool. Recently MultiSpec Online was used in a geospatial data session with 30-35 middle school students at the Turned Onto Technology and Leadership (TOTAL) Camp in the summers of 2016 and 2017 at Purdue University. The students worked on a flood mapping exercise using Landsat 5 data to learn about land remote sensing using supervised classification techniques. Online documentation is available for MultiSpec (engineering.purdue.edu/ biehl/MultiSpec/) including a reference manual and several tutorials allowing young high-school students through research faculty to learn the basic functions in MultiSpec. Some of the tutorials have been translated to other languages by MultiSpec users.

Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 2

NASA Technical Reports Server (NTRS)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the second book of volume four. Some of the items it contains are specs for the emergency shutdown panel, specs for the simulator software, simulator hardware specs, site operator terminal requirements, control data system requirements, software project management plan, elastomeric teeter bearing requirement specs, specs for the controls electronic cabinet, and specs for bolt pretensioning.

A Quantum Network with Atoms and Photons

DTIC Science & Technology

2016-09-01

The long - term goal is to entangle distant atomic memories between ARL and JQI, and explore the possibility of entangling hybrid quantum memories . 2...ARL) environment. The long - term goal is to achieve a quantum repeater network capability for the US Army. Initially, a quantum channel between ARL and...SUBJECT  TERMS Quantum, atoms, photons, entanglement, teleportation, communications, network, memory 16. SECURITY CLASSIFICATION OF: 17. LIMITATION

A Quantum Network with Atoms and Photons

DTIC Science & Technology

2016-09-30

The long - term goal is to entangle distant atomic memories between ARL and JQI, and explore the possibility of entangling hybrid quantum memories . 2...ARL) environment. The long - term goal is to achieve a quantum repeater network capability for the US Army. Initially, a quantum channel between ARL and...SUBJECT  TERMS Quantum, atoms, photons, entanglement, teleportation, communications, network, memory 16. SECURITY CLASSIFICATION OF: 17. LIMITATION

Spec Tool; an online education and research resource

NASA Astrophysics Data System (ADS)

Maman, S.; Shenfeld, A.; Isaacson, S.; Blumberg, D. G.

2016-06-01

Education and public outreach (EPO) activities related to remote sensing, space, planetary and geo-physics sciences have been developed widely in the Earth and Planetary Image Facility (EPIF) at Ben-Gurion University of the Negev, Israel. These programs aim to motivate the learning of geo-scientific and technologic disciplines. For over the past decade, the facility hosts research and outreach activities for researchers, local community, school pupils, students and educators. As software and data are neither available nor affordable, the EPIF Spec tool was created as a web-based resource to assist in initial spectral analysis as a need for researchers and students. The tool is used both in the academic courses and in the outreach education programs and enables a better understanding of the theoretical data of spectroscopy and Imaging Spectroscopy in a 'hands-on' activity. This tool is available online and provides spectra visualization tools and basic analysis algorithms including Spectral plotting, Spectral angle mapping and Linear Unmixing. The tool enables to visualize spectral signatures from the USGS spectral library and additional spectra collected in the EPIF such as of dunes in southern Israel and from Turkmenistan. For researchers and educators, the tool allows loading collected samples locally for further analysis.

Ocean View

NASA Technical Reports Server (NTRS)

1999-01-01

Analytical Spectral Devices was able to commercialize the "engine" of SeaSpec. The Dual CCD developed for SeaSpec is used in our FieldSpecO Dual UV/VNIR/CCD. This product is very popular for coastal research. It allows for a small suitcase sized spectrometer to be placed in a boat and the attached fiber optic cable can be lowered 30 feet below the surface allowing researchers to perform the same studies as SeaSpec just not at the deep-water depths. Most of the people who inquire about SeaSpec end up purchasing a FieldSpec Dual CCD.SeaSpec was designed to withstand harsh marine environments and depths up to 200 m. While it meets these requirements it is the only instrument of its kind and we consider it a prototype. The first version was released in April 1997. It was tested, we made modification and returned the product in March 1998.

Detection and Localization of Vibrotactile Signals in Moving Vehicles

DTIC Science & Technology

2008-05-01

Detection and Localization of Vibrotactile Signals in Moving Vehicles by Andrea S . Krausman and Timothy L. White ARL-TR-4463 May 2008...Proving Ground, MD 21005-5425 ARL-TR-4463 May 2008 Detection and Localization of Vibrotactile Signals in Moving Vehicles Andrea S ...5e. TASK NUMBER 6. AUTHOR( S ) Andrea S . Krausman and Timothy L. White (both of ARL) 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION

76 FR 3118 - Notice of Availability of Advanced Battery Technology Related Patents for Exclusive, Partially...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-19

..., Less Expensive Lithium Ion Batteries (US 7,629,080). 6. ARL 05-18--High Capacity Metal/Air Battery... Resistance in Lithium Ion Batteries. Filed with USPTO on 2/3/2010 (S/N 12/699,182). 11. ARL 09-33--Pure LiBOB... Electrolytes for Lithium/Air Batteries (US 7,585,579). 2. ARL 02-06--Solvent Systems Comprising a Mixture of...

Recent advances in PC-Linux systems for electronic structure computations by optimized compilers and numerical libraries.

PubMed

Yu, Jen-Shiang K; Yu, Chin-Hui

2002-01-01

One of the most frequently used packages for electronic structure research, GAUSSIAN 98, is compiled on Linux systems with various hardware configurations, including AMD Athlon (with the "Thunderbird" core), AthlonMP, and AthlonXP (with the "Palomino" core) systems as well as the Intel Pentium 4 (with the "Willamette" core) machines. The default PGI FORTRAN compiler (pgf77) and the Intel FORTRAN compiler (ifc) are respectively employed with different architectural optimization options to compile GAUSSIAN 98 and test the performance improvement. In addition to the BLAS library included in revision A.11 of this package, the Automatically Tuned Linear Algebra Software (ATLAS) library is linked against the binary executables to improve the performance. Various Hartree-Fock, density-functional theories, and the MP2 calculations are done for benchmarking purposes. It is found that the combination of ifc with ATLAS library gives the best performance for GAUSSIAN 98 on all of these PC-Linux computers, including AMD and Intel CPUs. Even on AMD systems, the Intel FORTRAN compiler invariably produces binaries with better performance than pgf77. The enhancement provided by the ATLAS library is more significant for post-Hartree-Fock calculations. The performance on one single CPU is potentially as good as that on an Alpha 21264A workstation or an SGI supercomputer. The floating-point marks by SpecFP2000 have similar trends to the results of GAUSSIAN 98 package.

A Moderate Resolution NIR Spectral Library of Weak-Lined T Tauri Stars

NASA Astrophysics Data System (ADS)

Cooper, Rachel; Covey, K. R.

2013-01-01

We present a spectral library of high-quality moderate resolution (R ~ 3500) NIR spectra for 44 weak-lined T Tauri Stars (WTTS) in the Taurus-Auriga Molecular Cloud. These spectra, obtained with the TripleSpec spectrograph on the Astrophysical Research Consortium (ARC) 3.5 meter telescope, provide full coverage of the J, H, and K near-infrared bands in a single epoch. Analyzing these spectra, along with those of dwarf and giant spectral type standards from the SpeX Spectral Library, we have identified several elemental and molecular absorption lines that vary in strength with respect to each star's spectral type and luminosity class. Calibrating each of these features as a spectral type indicator, we provide a detailed characterization for each of the WTTSs in our sample, identifying each star's NIR spectral type and line-of-sight extinction, estimated both from the shape of the overall continuum and from the fluxes of the Paschen beta and Brackett gamma emission lines. In addition to improving our understanding of the properties of these WTTSs, this well characterized spectral library will be a valuable resource for analyses of the NIR continuum veiling and line emission present in the spectra of accreting classical T Tauri stars. This research was made possible by NSF Grant AST-1004107.

US Army Research Laboratory (ARL) Standard for Characterization of Electric-Field Sensors, 10 Hz to 10 kHz

DTIC Science & Technology

2016-11-01

Disclaimers The findings in this report are not to be construed as an official Department of the Army position unless so designated by other...unlimited. 13. SUPPLEMENTARY NOTES 14. ABSTRACT The US Army Research Laboratory (ARL) has designed and build a one-of-a-kind electric-field sensor...direction. (Right) Computer- aided design model of the ARL electric-field cage with insulated mounting

A Revised Interface for the ARL Topodef Mobility Design Tool

DTIC Science & Technology

2012-04-01

designed paths as though moving down a conveyor belt . Giving paths an existence independent of the nodes that travel along them not only makes their...A Revised Interface for the ARL Topodef Mobility Design Tool by Andrew J. Toth and Michael Christensen ARL-TR-5980 April 2012...Disclaimers The findings in this report are not to be construed as an official Department of the Army position unless so designated by other

Human-Systems Integration (HSI) and the Network Integration Evaluations (NIEs), Part 3: Mitigating Cognitive Load in Network-Enabled Mission Command

DTIC Science & Technology

2016-06-01

ARL-TR-7698 ● JUNE 2016 US Army Research Laboratory Human -Systems Integration (HSI) and the Network Integration Evaluations...ARL-TR-7698 ● JUNE 2016 US Army Research Laboratory Human -Systems Integration (HSI) and the Network Integration Evaluations (NIEs), Part 3...Mitigating Cognitive Load in Network-Enabled Mission Command by John K Hawley Human Research and Engineering Directorate, ARL Michael W

Influence of Test Section Geometry on the Blast Environment in an Explosively Driven Conical Shock Tube

DTIC Science & Technology

2018-03-30

ARL-TR-8335•MAR 2018 US Army Research Laboratory Influence of Test Section Geometry on theBlast Environment in an Explosively DrivenConical Shock...ARL-TR-8335•MAR 2018 US Army Research Laboratory Influence of Test Section Geometry on theBlast Environment in an Explosively DrivenConical Shock...Tube by Joel B Stewart Weapons and Materials Research Directorate, ARL Approved for public release; distribution is unlimited. REPORT DOCUMENTATION

Taxonomic descriptions of three marine colepid ciliates, Nolandia sinica spec. nov., Apocoleps caoi spec. nov. and Tiarina fusa (Claparede & Lachmann, 1858) Bergh, 1881 (Ciliophora, Prorodontida).

PubMed

Chen, Xiangrui; Gao, Shan; Liu, Weiwei; Song, Weibo; Al-Rasheid, Khaled A S; Warren, Alan

2012-03-01

The morphology of three marine colepid ciliates, Nolandia sinica spec. nov., Apocoleps caoi spec. nov. and Tiarina fusa (Claparède & Lachmann, 1858) Bergh, 1881, isolated from Chinese coastal waters, was investigated. N. sinica spec. nov. may be separated from its congeners by the structure of its armour plates, each of which may have up to five reniform windows. A. caoi spec. nov. is characterized by its large body with broad anterior end and by having 10-12 long, sharp posterior spines. New data and an improved diagnosis are supplied for Tiarina fusa (Claparède & Lachmann, 1858) Bergh, 1881, which has a spindle-shaped body, about 16 ciliary rows and a single adoral organelle. Sequence similarities with other available colepid species were determined.

SpecTAD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zamora, Richard; Voter, Arthur; Uberuaga, Bla

2017-10-23

The SpecTAD software represents a refactoring of the Temperature Accelerated Dynamics (TAD2) code authored by Arthur F. Voter and Blas P. Uberuaga (LA-CC-02-05). SpecTAD extends the capabilities of TAD2, by providing algorithms for both temporal and spatial parallelism. The novel algorithms for temporal parallelism include both speculation and replication based techniques. SpecTAD also offers the optional capability to dynamically link to the open-source LAMMPS package.

2nd Annual Postdoc Research Day: US Army Research Laboratory PosterSymposia and Activities

DTIC Science & Technology

2018-04-12

ARL-SR-0394•APR 2018 US Army Research Laboratory 2nd Annual Postdoc Research Day: US Army Research Laboratory Poster Symposia and Activities by...Do not return it to the originator. ARL-SR-0394•APR 2018 US Army Research Laboratory 2nd Annual Postdoc Research Day: US Army Research Laboratory...Poster Symposia and Activities by Efraín Hernández–Rivera Weapons and Materials Research Directorate, ARL Julia Cline Oak Ridge Institute for Science and

MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells

PubMed Central

Zhou, Y; Jiang, H; Gu, J; Tang, Y; Shen, N; Jin, Y

2013-01-01

Neural progenitor cells (NPCs) derived from human embryonic stem cells (hESCs) have great potential in cell therapy, drug screening and toxicity testing of neural degenerative diseases. However, the molecular regulation of their proliferation and apoptosis, which needs to be revealed before clinical application, is largely unknown. MicroRNA miR-195 is known to be expressed in the brain and is involved in a variety of proapoptosis or antiapoptosis processes in cancer cells. Here, we defined the proapoptotic role of miR-195 in NPCs derived from two independent hESC lines (human embryonic stem cell-derived neural progenitor cells, hESC-NPCs). Overexpression of miR-195 in hESC-NPCs induced extensive apoptotic cell death. Consistently, global transcriptional microarray analyses indicated that miR-195 primarily regulated genes associated with apoptosis in hESC-NPCs. Mechanistically, a small GTP-binding protein ADP-ribosylation factor-like protein 2 (ARL2) was identified as a direct target of miR-195. Silencing ARL2 in hESC-NPCs provoked an apoptotic phenotype resembling that of miR-195 overexpression, revealing for the first time an essential role of ARL2 for the survival of human NPCs. Moreover, forced expression of ALR2 could abolish the cell number reduction caused by miR-195 overexpression. Interestingly, we found that paraquat, a neurotoxin, not only induced apoptosis but also increased miR-195 and reduced ARL2 expression in hESC-NPCs, indicating the possible involvement of miR-195 and ARL2 in neurotoxin-induced NPC apoptosis. Notably, inhibition of miR-195 family members could block neurotoxin-induced NPC apoptosis. Collectively, miR-195 regulates cell apoptosis in a context-dependent manner through directly targeting ARL2. The finding of the critical role of ARL2 for the survival of human NPCs and association of miR-195 and ARL2 with neurotoxin-induced apoptosis have important implications for understanding molecular mechanisms that control NPC survival and would facilitate our manipulation of the neurological pathogenesis. PMID:23807224

Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells.

PubMed

Yamauchi, Junji; Miyamoto, Yuki; Torii, Tomohiro; Mizutani, Reiko; Nakamura, Kazuaki; Sanbe, Atsushi; Koide, Hiroshi; Kusakawa, Shinji; Tanoue, Akito

2009-07-15

The mood-stabilizing agent valproic acid (VPA) potently promotes neuronal differentiation. As yet, however, little is known about the underlying molecular mechanism. Here, we show that VPA upregulates cytohesin-2 and mediates neurite outgrowth in N1E-115 neuroblastoma cells. Cytohesin-2 is the guanine-nucleotide exchange factor (GEF) for small GTPases of the Arf family; it regulates many aspects of cellular functions including morphological changes. Treatment with the specific cytohesin family inhibitor SecinH3 or knockdown of cytohesin-2 with its siRNA results in blunted induction of neurite outgrowth in N1E-115 cells. The outgrowth is specifically inhibited by siRNA knockdown of Arf6, but not by that of Arf1. Furthermore, VPA upregulates Arl4D, an Arf-like small GTPase that has recently been identified as the regulator that binds to cytohesin-2. Arl4D knockdown displays an inhibitory effect on neurite outgrowth resulting from VPA, while expression of constitutively active Arl4D induces outgrowth. We also demonstrate that the addition of cell-permeable peptide, coupling the cytohesin-2-binding region of Arl4D into cells, reduces the effect of VPA. Thus, Arl4D is a previously unknown regulator of neurite formation through cytohesin-2 and Arf6, providing another example that the functional interaction of two different small GTPases controls an important cellular function.

Staphylococcus aureus Develops an Alternative, ica-Independent Biofilm in the Absence of the arlRS Two-Component System†

PubMed Central

Toledo-Arana, Alejandro; Merino, Nekane; Vergara-Irigaray, Marta; Débarbouillé, Michel; Penadés, José R.; Lasa, Iñigo

2005-01-01

The biofilm formation capacity of Staphylococcus aureus clinical isolates is considered an important virulence factor for the establishment of chronic infections. Environmental conditions affect the biofilm formation capacity of S. aureus, indicating the existence of positive and negative regulators of the process. The majority of the screening procedures for identifying genes involved in biofilm development have been focused on genes whose presence is essential for the process. In this report, we have used random transposon mutagenesis and systematic disruption of all S. aureus two-component systems to identify negative regulators of S. aureus biofilm development in a chemically defined medium (Hussain-Hastings-White modified medium [HHWm]). The results of both approaches coincided in that they identified arlRS as a repressor of biofilm development under both steady-state and flow conditions. The arlRS mutant exhibited an increased initial attachment as well as increased accumulation of poly-N-acetylglucosamine (PNAG). However, the biofilm formation of the arlRS mutant was not affected when the icaADBC operon was deleted, indicating that PNAG is not an essential compound of the biofilm matrix produced in HHWm. Disruption of the major autolysin gene, atl, did not produce any effect on the biofilm phenotype of an arlRS mutant. Epistatic experiments with global regulators involved in staphylococcal-biofilm formation indicated that sarA deletion abolished, whereas agr deletion reinforced, the biofilm development promoted by the arlRS mutation. PMID:16030226

Numerical performance and throughput benchmark for electronic structure calculations in PC-Linux systems with new architectures, updated compilers, and libraries.

PubMed

Yu, Jen-Shiang K; Hwang, Jenn-Kang; Tang, Chuan Yi; Yu, Chin-Hui

2004-01-01

A number of recently released numerical libraries including Automatically Tuned Linear Algebra Subroutines (ATLAS) library, Intel Math Kernel Library (MKL), GOTO numerical library, and AMD Core Math Library (ACML) for AMD Opteron processors, are linked against the executables of the Gaussian 98 electronic structure calculation package, which is compiled by updated versions of Fortran compilers such as Intel Fortran compiler (ifc/efc) 7.1 and PGI Fortran compiler (pgf77/pgf90) 5.0. The ifc 7.1 delivers about 3% of improvement on 32-bit machines compared to the former version 6.0. Performance improved from pgf77 3.3 to 5.0 is also around 3% when utilizing the original unmodified optimization options of the compiler enclosed in the software. Nevertheless, if extensive compiler tuning options are used, the speed can be further accelerated to about 25%. The performances of these fully optimized numerical libraries are similar. The double-precision floating-point (FP) instruction sets (SSE2) are also functional on AMD Opteron processors operated in 32-bit compilation, and Intel Fortran compiler has performed better optimization. Hardware-level tuning is able to improve memory bandwidth by adjusting the DRAM timing, and the efficiency in the CL2 mode is further accelerated by 2.6% compared to that of the CL2.5 mode. The FP throughput is measured by simultaneous execution of two identical copies of each of the test jobs. Resultant performance impact suggests that IA64 and AMD64 architectures are able to fulfill significantly higher throughput than the IA32, which is consistent with the SpecFPrate2000 benchmarks.

ARL participation in the C4ISR OTM experiment: integration and performance results

NASA Astrophysics Data System (ADS)

Zong, Lei; O'Brien, Barry J.

2007-04-01

The Command, Control, Communication, Computers, Intelligence, Surveillance and Reconnaissance (C4ISR) On-The- Move (OTM) demonstration is an annual showcase of how innovative technologies can help modern troops increase their situational awareness (SA) in battlefield environments. To evaluate the effectiveness these new technologies have on the soldiers' abilities to gather situational information, the demonstration involves United States Army National Guard troops in realistic war game scenarios at an Army Reserve training ground. The Army Research Laboratory (ARL) was invited to participate in the event, with the objective demonstrating system-level integration of disparate technologies developed for gathering SA information in small unit combat operations. ARL provided expertise in Unattended Ground Sensing (UGS) technology, Unmanned Ground Vehicle (UGV) technology, information processing and wireless mobile ad hoc communication. The ARL C4ISR system included a system of multimodal sensors (MMS), a trip wire imager, a man-portable robotic vehicle (PackBot), and low power sensor radios for communication between an ARL system and a hosting platoon vehicle. This paper will focus on the integration effort of bringing the multiple families of sensor assets together into a working system.

Modeling and Simulation of Ceramic Arrays to Improve Ballaistic Performance

DTIC Science & Technology

2013-07-01

Ref: ARL-TR- 2219 , 2000.) Al 5083 .30 Caliber AP-M2 E ^Projectile — 3.918 mm tAj = 76.2 mm H = 20.0 mm VP = 400 - 900 m/s Al ^ Al H 2013...reference - ARL-TR- 2219 , 2000. 15. SUBJECT TERMS .30cal AP M2 Projectile, 762x39 PS Projectile, SPH, Aluminum 5083, SiC, DoP Expeminets, AutoDyn...on the DoP experiments described in reference - ARL-TR- 2219 , 2000. 2013 © University of Delaware DOP OF .30cal PROJECTILE INTO MONOLITHIC ALUMINUM

ARL Arabic Dependency Treebank

DTIC Science & Technology

2016-02-10

This technical note describes the US Army Research Laboratory (ARL) Arabic Dependency Treebank (AADT) for the purpose of documenting its release. The...AADT was derived from existing Arabic treebanks distributed by the Linguistic Data Consortium using constituent-to- dependency conversion software

ARL Collaborative Research Alliance Materials in Extreme Dynamic Environments (MEDE)

DTIC Science & Technology

2010-11-19

Program Internal to the CRA Staff Rotation Lectures, Workshops, and Research Reviews Education Opportunities for Government Personnel Student ... Engagement with ARL Research Environment Industry Partnership + Collaboration Other Collaboration Opportunities High Performance Computing DoD

Autophagy in Saccharomyces cerevisiae requires the monomeric GTP-binding proteins, Arl1 and Ypt6.

PubMed

Yang, Shu; Rosenwald, Anne G

2016-10-02

Macroautophagy/autophagy is a cellular degradation process that sequesters organelles or proteins into a double-membrane structure called the phagophore; this transient compartment matures into an autophagosome, which then fuses with the lysosome or vacuole to allow hydrolysis of the cargo. Factors that control membrane traffic are also essential for each step of autophagy. Here we demonstrate that 2 monomeric GTP-binding proteins in Saccharomyces cerevisiae, Arl1 and Ypt6, which belong to the Arf/Arl/Sar protein family and the Rab family, respectively, and control endosome-trans-Golgi traffic, are also necessary for starvation-induced autophagy under high temperature stress. Using established autophagy-specific assays we found that cells lacking either ARL1 or YPT6, which exhibit synthetic lethality with one another, were unable to undergo autophagy at an elevated temperature, although autophagy proceeds normally at normal growth temperature; specifically, strains lacking one or the other of these genes are unable to construct the autophagosome because these 2 proteins are required for proper traffic of Atg9 to the phagophore assembly site (PAS) at the restrictive temperature. Using degron technology to construct an inducible arl1Δ ypt6Δ double mutant, we demonstrated that cells lacking both genes show defects in starvation-inducted autophagy at the permissive temperature. We also found Arl1 and Ypt6 participate in autophagy by targeting the Golgi-associated retrograde protein (GARP) complex to the PAS to regulate the anterograde trafficking of Atg9. Our data show that these 2 membrane traffic regulators have novel roles in autophagy.

Porting Extremely Lightweight Intrusion Detection (ELIDe) to Android

DTIC Science & Technology

2015-10-01

ARL-TN-0681 ● OCT 2015 US Army Research Laboratory Porting Extremely Lightweight Intrusion Detection (ELIDe) to Android by...Lightweight Intrusion Detection (ELIDe) to Android by Ken F Yu and Garret S Payer Computational and Information Sciences Directorate, ARL...

xiSPEC: web-based visualization, analysis and sharing of proteomics data.

PubMed

Kolbowski, Lars; Combe, Colin; Rappsilber, Juri

2018-05-08

We present xiSPEC, a standard compliant, next-generation web-based spectrum viewer for visualizing, analyzing and sharing mass spectrometry data. Peptide-spectrum matches from standard proteomics and cross-linking experiments are supported. xiSPEC is to date the only browser-based tool supporting the standardized file formats mzML and mzIdentML defined by the proteomics standards initiative. Users can either upload data directly or select files from the PRIDE data repository as input. xiSPEC allows users to save and share their datasets publicly or password protected for providing access to collaborators or readers and reviewers of manuscripts. The identification table features advanced interaction controls and spectra are presented in three interconnected views: (i) annotated mass spectrum, (ii) peptide sequence fragmentation key and (iii) quality control error plots of matched fragments. Highlighting or selecting data points in any view is represented in all other views. Views are interactive scalable vector graphic elements, which can be exported, e.g. for use in publication. xiSPEC allows for re-annotation of spectra for easy hypothesis testing by modifying input data. xiSPEC is freely accessible at http://spectrumviewer.org and the source code is openly available on https://github.com/Rappsilber-Laboratory/xiSPEC.

Impact of the differential fluence distribution of brachytherapy sources on the spectroscopic dose-rate constant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malin, Martha J.; Bartol, Laura J.; DeWerd, Larry A., E-mail: mmalin@wisc.edu, E-mail: ladewerd@wisc.edu

2015-05-15

Purpose: To investigate why dose-rate constants for {sup 125}I and {sup 103}Pd seeds computed using the spectroscopic technique, Λ{sub spec}, differ from those computed with standard Monte Carlo (MC) techniques. A potential cause of these discrepancies is the spectroscopic technique’s use of approximations of the true fluence distribution leaving the source, φ{sub full}. In particular, the fluence distribution used in the spectroscopic technique, φ{sub spec}, approximates the spatial, angular, and energy distributions of φ{sub full}. This work quantified the extent to which each of these approximations affects the accuracy of Λ{sub spec}. Additionally, this study investigated how the simplified water-onlymore » model used in the spectroscopic technique impacts the accuracy of Λ{sub spec}. Methods: Dose-rate constants as described in the AAPM TG-43U1 report, Λ{sub full}, were computed with MC simulations using the full source geometry for each of 14 different {sup 125}I and 6 different {sup 103}Pd source models. In addition, the spectrum emitted along the perpendicular bisector of each source was simulated in vacuum using the full source model and used to compute Λ{sub spec}. Λ{sub spec} was compared to Λ{sub full} to verify the discrepancy reported by Rodriguez and Rogers. Using MC simulations, a phase space of the fluence leaving the encapsulation of each full source model was created. The spatial and angular distributions of φ{sub full} were extracted from the phase spaces and were qualitatively compared to those used by φ{sub spec}. Additionally, each phase space was modified to reflect one of the approximated distributions (spatial, angular, or energy) used by φ{sub spec}. The dose-rate constant resulting from using approximated distribution i, Λ{sub approx,i}, was computed using the modified phase space and compared to Λ{sub full}. For each source, this process was repeated for each approximation in order to determine which approximations used in the spectroscopic technique affect the accuracy of Λ{sub spec}. Results: For all sources studied, the angular and spatial distributions of φ{sub full} were more complex than the distributions used in φ{sub spec}. Differences between Λ{sub spec} and Λ{sub full} ranged from −0.6% to +6.4%, confirming the discrepancies found by Rodriguez and Rogers. The largest contribution to the discrepancy was the assumption of isotropic emission in φ{sub spec}, which caused differences in Λ of up to +5.3% relative to Λ{sub full}. Use of the approximated spatial and energy distributions caused smaller average discrepancies in Λ of −0.4% and +0.1%, respectively. The water-only model introduced an average discrepancy in Λ of −0.4%. Conclusions: The approximations used in φ{sub spec} caused discrepancies between Λ{sub approx,i} and Λ{sub full} of up to 7.8%. With the exception of the energy distribution, the approximations used in φ{sub spec} contributed to this discrepancy for all source models studied. To improve the accuracy of Λ{sub spec}, the spatial and angular distributions of φ{sub full} could be measured, with the measurements replacing the approximated distributions. The methodology used in this work could be used to determine the resolution that such measurements would require by computing the dose-rate constants from phase spaces modified to reflect φ{sub full} binned at different spatial and angular resolutions.« less

Determining the perceived value of information when combining supporting and conflicting data

NASA Astrophysics Data System (ADS)

Hanratty, Timothy; Heilman, Eric; Richardson, John; Mittrick, Mark; Caylor, Justine

2017-05-01

Modern military intelligence operations involves a deluge of information from a large number of sources. A data ranking algorithm that enables the most valuable information to be reviewed first may improve timely and effective analysis. This ranking is termed the value of information (VoI) and its calculation is a current area of research within the US Army Research Laboratory (ARL). ARL has conducted an experiment to correlate the perceptions of subject matter experts with the ARL VoI model and additionally to construct a cognitive model of the ranking process and the amalgamation of supporting and conflicting information.

VizieR Online Data Catalog: FADO code (Gomes+, 2017)

NASA Astrophysics Data System (ADS)

Gomes, J. M.; Papaderos, P.

2017-03-01

FADO comes from the Latin word "fatum" that means fate or destiny. It is also a well known genre of Portuguese music, and by choosing this acronym for this spectral synthesis tool we would like to pay tribute to Portugal. The main goal of FADO is to explore the star-formation and chemical enrichment history (the "Fado") of galaxies based on two hitherto unique elements in spectral fitting models: a) self-consistency between the best-fitting star formation history (SFH) and the nebular characteristics of a galaxy (e.g., hydrogen Balmer-line luminosities and equivalent widths; shape of the nebular continuum, including the Balmer and Paschen discontinuity) and b) genetic optimization and artificial intelligence algorithms. This document is part of the FADO v.1 distribution package, which contains two different ascii files, ReadMe and Read_F, and one tarball archive FADOv1.tar.gz. FADOv1.tar.gz contains the binary (executable) compiled in both OpenSuSE 13.2 64bit LINUX (FADO) and MAC OS X (FADO_MACOSX). The former is compatible with most LINUX distributions, while the latter was only tested for Yosemite 10.10.3. It contains the configuration files for running FADO: FADO.config and PLOT.config, as well as the "Simple Stellar Population" (SSP) base library with the base file list Base.BC03.L, the FADO v.1 short manual Read_F and this file (in the ReadMe directory) and, for testing purposes, three characteristic de-redshifted spectra from SDSS-DR7 in ascii format, corresponding to a star-forming (spec1.txt), composite (spec2.txt) and LINER (spec3.txt) galaxy. Auxiliary files needed for execution of FADO (.HIfboundem.ascii, .HeIIfbound.ascii, .HeIfboundem.ascii, grfont.dat and grfont.txt) are also included in the tarball. By decompressing the tarball the following six directories are created: input, output, plots, ReadMe, SSPs and tables (see below for a brief explanation). (2 data files).

Wavelet Analysis for Molecular Dynamics

DTIC Science & Technology

2015-06-01

Research Directorate, ARL Jaydeep P Bardhan Dept. of Mechanical and Industrial Engineering, Northeastern University Boston, MA Ahmed E Ismail Dept. of...Rinderspacher, Jaydeep P Bardhan , and Ahmed E Ismail ARL-MR-0891 Approved for public release; distribution is unlimited. October 2013–September 2014 US Army

Evaluation of Thermoelectric Devices by the Slope-Efficiency Method

DTIC Science & Technology

2016-09-01

ARL-TR-7837 ● SEP 2016 US Army Research Laboratory Evaluation of Thermoelectric Devices by the Slope-Efficiency Method by...Evaluation of Thermoelectric Devices by the Slope-Efficiency Method by Patrick J Taylor Sensors and Electron Devices Directorate, ARL Jay R...

Action Learning.

ERIC Educational Resources Information Center

1996

These four papers were presented at a symposium on action learning moderated by Lex Dilworth at the 1996 conference of the Academy of Human Resource Development. "Developing an Infrastructure for Individual and Organizational Change: Transfer of Learning from an Action Reflection Learning (ARL) Program" (ARL Inquiry) reports findings…

Assessment of Energy Efficient and Model Based Control

DTIC Science & Technology

2017-06-15

ARL-TR-8042 ● JUNE 2017 US Army Research Laboratory Assessment of Energy -Efficient and Model- Based Control by Craig Lennon...originator. ARL-TR-8042 ● JUNE 2017 US Army Research Laboratory Assessment of Energy -Efficient and Model- Based Control by Craig...

SPECS: The Kilometer-baseline Far-IR Interferometer in NASA's Space Science Roadmap Presentation

NASA Technical Reports Server (NTRS)

Abel, Tom; Allen, Ron; Benford, Dominic; Blain, Andrew; Bombardelli, Claudio; Calzetti, Daniela; DiPirro, Michael J.; Ehrenfreund, Pascale; Evans, Neal; Fischer, Jackie

2004-01-01

A viewgraph presentation describing the Submillimeter Probe of the Evolution of Cosmic Structure (SPECS) mission is shown. The topics include: 1) Context: community planning and study status; 2) Science goals; 3) Mission requirements; 4) Mission concepts for SPIRIT and SPECS; and 5) Tethered formation flying, a key enabling technology.

NOAA ARL Field Research Division

Science.gov Websites

quality managers become better informed about how and where air pollution is moving and what populations may be affected. Using this science-based information, air quality controls and regulations can be Commerce | NOAA | NOAA Research | ARL | FRD Privacy | Disclaimer | Information Quality | webmaster

Semi-Automated Processing of Trajectory Simulator Output Files for Model Evaluation

DTIC Science & Technology

2018-01-01

ARL-TR-8284 ● JAN 2018 US Army Research Laboratory Semi-Automated Processing of Trajectory Simulator Output Files for Model......Do not return it to the originator. ARL-TR-8284 ● JAN 2018 US Army Research Laboratory Semi-Automated Processing of Trajectory

The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression

PubMed Central

Crosby, Heidi A.; Schlievert, Patrick M.; Merriman, Joseph A.; King, Jessica M.; Salgado-Pabón, Wilmara; Horswill, Alexander R.

2016-01-01

Staphylococcus aureus is a human commensal and opportunistic pathogen that causes devastating infections in a wide range of locations within the body. One of the defining characteristics of S. aureus is its ability to form clumps in the presence of soluble fibrinogen, which likely has a protective benefit and facilitates adhesion to host tissue. We have previously shown that the ArlRS two-component regulatory system controls clumping, in part by repressing production of the large surface protein Ebh. In this work we show that ArlRS does not directly regulate Ebh, but instead ArlRS activates expression of the global regulator MgrA. Strains lacking mgrA fail to clump in the presence of fibrinogen, and clumping can be restored to an arlRS mutant by overexpressing either arlRS or mgrA, indicating that ArlRS and MgrA constitute a regulatory pathway. We used RNA-seq to show that MgrA represses ebh, as well as seven cell wall-associated proteins (SraP, Spa, FnbB, SasG, SasC, FmtB, and SdrD). EMSA analysis showed that MgrA directly represses expression of ebh and sraP. Clumping can be restored to an mgrA mutant by deleting the genes for Ebh, SraP and SasG, suggesting that increased expression of these proteins blocks clumping by steric hindrance. We show that mgrA mutants are less virulent in a rabbit model of endocarditis, and virulence can be partially restored by deleting the genes for the surface proteins ebh, sraP, and sasG. While mgrA mutants are unable to clump, they are known to have enhanced biofilm capacity. We demonstrate that this increase in biofilm formation is partially due to up-regulation of SasG, a surface protein known to promote intercellular interactions. These results confirm that ArlRS and MgrA constitute a regulatory cascade, and that they control expression of a number of genes important for virulence, including those for eight large surface proteins. PMID:27144398

A Pilot Study of the Effectiveness of Augmented Reality to Enhance the Use of Remote Labs in Electrical Engineering Education

NASA Astrophysics Data System (ADS)

Mejías Borrero, A.; Andújar Márquez, J. M.

2012-10-01

Lab practices are an essential part of teaching in Engineering. However, traditional laboratory lessons developed in classroom labs (CL) must be adapted to teaching and learning strategies that go far beyond the common concept of e-learning, in the sense that completely virtualized distance education disconnects teachers and students from the real world, which can generate specific problems in laboratory classes. Current proposals of virtual labs (VL) and remote labs (RL) do not either cover new needs properly or contribute remarkable improvement to traditional labs—except that they favor distance training. Therefore, online teaching and learning in lab practices demand a further step beyond current VL and RL. This paper poses a new reality and new teaching/learning concepts in the field of lab practices in engineering. The developed augmented reality-based lab system (augmented remote lab, ARL) enables teachers and students to work remotely (Internet/intranet) in current CL, including virtual elements which interact with real ones. An educational experience was conducted to assess the developed ARL with the participation of a group of 10 teachers and another group of 20 students. Both groups have completed lab practices of the contents in the subjects Digital Systems and Robotics and Industrial Automation, which belong to the second year of the new degree in Electronic Engineering (adapted to the European Space for Higher Education). The labs were carried out by means of three different possibilities: CL, VL and ARL. After completion, both groups were asked to fill in some questionnaires aimed at measuring the improvement contributed by ARL relative to CL and VL. Except in some specific questions, the opinion of teachers and students was rather similar and positive regarding the use and possibilities of ARL. Although the results are still preliminary and need further study, seems to conclude that ARL remarkably improves the possibilities of current VL and RL. Furthermore, ARL can be concluded to allow further possibilities when used online than traditional laboratory lessons completed in CL.

United States Air Force Analysis Extract AFSC 2A6X4 Aircraft Fuel Systems (ANG/AFRC)

DTIC Science & Technology

2001-02-01

8217AFOMS (AETC) Randolph AFB TX’ V0226 Spec tools/equip use/oper - Rollers or Stitchers ...8217 V0226 Spec tools/equip use/oper - Rollers or Stitchers ANG ANG ANG RES RES...8217AFOMS (AETC) Randolph AFB TX’ V0226 Spec tools/equip use/oper - Rollers or Stitchers

High Sensitivity Crosslink Detection Coupled With Integrative Structure Modeling in the Mass Spec Studio *

PubMed Central

Sarpe, Vladimir; Rafiei, Atefeh; Hepburn, Morgan; Ostan, Nicholas; Schryvers, Anthony B.; Schriemer, David C.

2016-01-01

The Mass Spec Studio package was designed to support the extraction of hydrogen-deuterium exchange and covalent labeling data for a range of mass spectrometry (MS)-based workflows, to integrate with restraint-driven protein modeling activities. In this report, we present an extension of the underlying Studio framework and provide a plug-in for crosslink (XL) detection. To accommodate flexibility in XL methods and applications, while maintaining efficient data processing, the plug-in employs a peptide library reduction strategy via a presearch of the tandem-MS data. We demonstrate that prescoring linear unmodified peptide tags using a probabilistic approach substantially reduces search space by requiring both crosslinked peptides to generate sparse data attributable to their linear forms. The method demonstrates highly sensitive crosslink peptide identification with a low false positive rate. Integration with a Haddock plug-in provides a resource that can combine multiple sources of data for protein modeling activities. We generated a structural model of porcine transferrin bound to TbpB, a membrane-bound receptor essential for iron acquisition in Actinobacillus pleuropneumoniae. Using mutational data and crosslinking restraints, we confirm the mechanism by which TbpB recognizes the iron-loaded form of transferrin, and note the requirement for disparate sources of restraint data for accurate model construction. The software plugin is freely available at www.msstudio.ca. PMID:27412762

High Sensitivity Crosslink Detection Coupled With Integrative Structure Modeling in the Mass Spec Studio.

PubMed

Sarpe, Vladimir; Rafiei, Atefeh; Hepburn, Morgan; Ostan, Nicholas; Schryvers, Anthony B; Schriemer, David C

2016-09-01

The Mass Spec Studio package was designed to support the extraction of hydrogen-deuterium exchange and covalent labeling data for a range of mass spectrometry (MS)-based workflows, to integrate with restraint-driven protein modeling activities. In this report, we present an extension of the underlying Studio framework and provide a plug-in for crosslink (XL) detection. To accommodate flexibility in XL methods and applications, while maintaining efficient data processing, the plug-in employs a peptide library reduction strategy via a presearch of the tandem-MS data. We demonstrate that prescoring linear unmodified peptide tags using a probabilistic approach substantially reduces search space by requiring both crosslinked peptides to generate sparse data attributable to their linear forms. The method demonstrates highly sensitive crosslink peptide identification with a low false positive rate. Integration with a Haddock plug-in provides a resource that can combine multiple sources of data for protein modeling activities. We generated a structural model of porcine transferrin bound to TbpB, a membrane-bound receptor essential for iron acquisition in Actinobacillus pleuropneumoniae Using mutational data and crosslinking restraints, we confirm the mechanism by which TbpB recognizes the iron-loaded form of transferrin, and note the requirement for disparate sources of restraint data for accurate model construction. The software plugin is freely available at www.msstudio.ca. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Defining defect specifications to optimize photomask production and requalification

NASA Astrophysics Data System (ADS)

Fiekowsky, Peter

2006-10-01

Reducing defect repairs and accelerating defect analysis is becoming more important as the total cost of defect repairs on advanced masks increases. Photomask defect specs based on printability, as measured on AIMS microscopes has been used for years, but the fundamental defect spec is still the defect size, as measured on the photomask, requiring the repair of many unprintable defects. ADAS, the Automated Defect Analysis System from AVI is now available in most advanced mask shops. It makes the use of pure printability specs, or "Optimal Defect Specs" practical. This software uses advanced algorithms to eliminate false defects caused by approximations in the inspection algorithm, classify each defect, simulate each defect and disposition each defect based on its printability and location. This paper defines "optimal defect specs", explains why they are now practical and economic, gives a method of determining them and provides accuracy data.

Generalized Optimal-State-Constraint Extended Kalman Filter (OSC-EKF)

DTIC Science & Technology

2017-02-01

ARL-TR-7948• FEB 2017 US Army Research Laboratory GeneralizedOptimal-State-Constraint ExtendedKalman Filter (OSC-EKF) by James M Maley, Kevin...originator. ARL-TR-7948• FEB 2017 US Army Research Laboratory GeneralizedOptimal-State-Constraint ExtendedKalman Filter (OSC-EKF) by James M Maley Weapons and...

Structure, Features, and Faculty Content in ARL Member Repositories

ERIC Educational Resources Information Center

Mercer, Holly; Koenig, Jay; McGeachin, Robert B.; Tucker, Sandra L.

2011-01-01

Questions about the optimal way to present repository content to authors, submitters, and end-users, prompted this study. The authors examined, through an observation and a survey, the institutional repositories of peer institutions in the ARL for good practices related to the presentation and organization of faculty-authored institutional…

Temperature Behavior of Thin Film Varactor

DTIC Science & Technology

2012-01-01

Temperature Behavior of Thin Film Varactor By Richard X. Fu ARL-TR-5905 January 2012...Thin Film Varactor Richard X. Fu Sensors and Electron Devices Directorate, ARL...DD-MM-YYYY) January 2012 2. REPORT TYPE Final 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Temperature Behavior of Thin Film Varactor 5a

Overlap Areas of a Square Box on a Square Mesh

DTIC Science & Technology

2017-04-01

ARL-TN-0818 ● APR 2017 US Army Research Laboratory Overlap Areas of a Square Box on a Square Mesh by James U Cazamias...originator. ARL-TN-0818 ● APR 2017 US Army Research Laboratory Overlap Areas of a Square Box on a Square Mesh by James U Cazamias...

Evaluation of ColorPAC Giardia/Cryptosporidium Rapid Assay and ProSpecT Giardia/Cryptosporidium Microplate Assay for Detection of Giardia and Cryptosporidium in Fecal Specimens

PubMed Central

Katanik, M. T.; Schneider, S. K.; Rosenblatt, J. E.; Hall, G. S.; Procop, G. W.

2001-01-01

Detection of Giardia and Cryptosporidium in clinical stool specimens using the ColorPAC and ProSpecT enzyme immunoassays revealed 98.7% agreement for Giardia detection and 98.1% agreement for Cryptosporidium detection. Sensitivities were uniformly 100%. The specificities of the ColorPAC immunoassay for Giardia and Cryptosporidium detection were 100 and 99.5%, respectively, and those for the ProSpecT assay were 98.4 and 98.6%, respectively. The false-positive reactions with the ProSpecT assay occurred with specimens that were grossly bloody. PMID:11724874

Fine-grained policy control in U.S. Army Research Laboratory (ARL) multimodal signatures database

NASA Astrophysics Data System (ADS)

Bennett, Kelly; Grueneberg, Keith; Wood, David; Calo, Seraphin

2014-06-01

The U.S. Army Research Laboratory (ARL) Multimodal Signatures Database (MMSDB) consists of a number of colocated relational databases representing a collection of data from various sensors. Role-based access to this data is granted to external organizations such as DoD contractors and other government agencies through a client Web portal. In the current MMSDB system, access control is only at the database and firewall level. In order to offer finer grained security, changes to existing user profile schemas and authentication mechanisms are usually needed. In this paper, we describe a software middleware architecture and implementation that allows fine-grained access control to the MMSDB at a dataset, table, and row level. Result sets from MMSDB queries issued in the client portal are filtered with the use of a policy enforcement proxy, with minimal changes to the existing client software and database. Before resulting data is returned to the client, policies are evaluated to determine if the user or role is authorized to access the data. Policies can be authored to filter data at the row, table or column level of a result set. The system uses various technologies developed in the International Technology Alliance in Network and Information Science (ITA) for policy-controlled information sharing and dissemination1. Use of the Policy Management Library provides a mechanism for the management and evaluation of policies to support finer grained access to the data in the MMSDB system. The GaianDB is a policy-enabled, federated database that acts as a proxy between the client application and the MMSDB system.

Three new species of Rectiostoma Becker, 1982 (Lepidoptera: Gelechioidea: Depressariidae) from Area de Conservación Guanacaste, northwestern Costa Rica

USDA-ARS?s Scientific Manuscript database

We describe three new species of Rectiostoma Becker, 1982 from Costa Rica: R. annemayae Heikkilä and Metz spec. nov., R. eowilsoni Heikkilä and Metz spec. nov. and R. philipmayi Heikkilä and Metz spec. nov. We used a data set of DNA COI-barcodes accumulated for Lepidoptera collected at Area de Conse...

Quantitative computed tomography applied to interstitial lung diseases.

PubMed

Obert, Martin; Kampschulte, Marian; Limburg, Rebekka; Barańczuk, Stefan; Krombach, Gabriele A

2018-03-01

To evaluate a new image marker that retrieves information from computed tomography (CT) density histograms, with respect to classification properties between different lung parenchyma groups. Furthermore, to conduct a comparison of the new image marker with conventional markers. Density histograms from 220 different subjects (normal = 71; emphysema = 73; fibrotic = 76) were used to compare the conventionally applied emphysema index (EI), 15 th percentile value (PV), mean value (MV), variance (V), skewness (S), kurtosis (K), with a new histogram's functional shape (HFS) method. Multinomial logistic regression (MLR) analyses was performed to calculate predictions of different lung parenchyma group membership using the individual methods, as well as combinations thereof, as covariates. Overall correct assigned subjects (OCA), sensitivity (sens), specificity (spec), and Nagelkerke's pseudo R 2 (NR 2 ) effect size were estimated. NR 2 was used to set up a ranking list of the different methods. MLR indicates the highest classification power (OCA of 92%; sens 0.95; spec 0.89; NR 2 0.95) when all histogram analyses methods were applied together in the MLR. Highest classification power among individually applied methods was found using the HFS concept (OCA 86%; sens 0.93; spec 0.79; NR 2 0.80). Conventional methods achieved lower classification potential on their own: EI (OCA 69%; sens 0.95; spec 0.26; NR 2 0.52); PV (OCA 69%; sens 0.90; spec 0.37; NR 2 0.57); MV (OCA 65%; sens 0.71; spec 0.58; NR 2 0.61); V (OCA 66%; sens 0.72; spec 0.53; NR 2 0.66); S (OCA 65%; sens 0.88; spec 0.26; NR 2 0.55); and K (OCA 63%; sens 0.90; spec 0.16; NR 2 0.48). The HFS method, which was so far applied to a CT bone density curve analysis, is also a remarkable information extraction tool for lung density histograms. Presumably, being a principle mathematical approach, the HFS method can extract valuable health related information also from histograms from complete different areas. Copyright © 2018 Elsevier B.V. All rights reserved.

[Morphological variablility in the chigger mite species Neotrombicula sympatrica (Acariformes: Trombiculidae) from Kyrgyzstan].

PubMed

Kharadov, A V

2002-01-01

Aberrations (quantitative chaetotactic deviations, i.e. decreasing or increasing of setae numbers and variations in arrangement of setae) and anomalies (qualitative chaetotactic deviations, for example, partial reduction of scutum, shortening of a seta more than 1.5-2 times, merging of setae) were recorded for 13 taxonomically important morphological structures in the chigger mite species Neotrombicula sympatrica Stekolnikov, 2001. 3308 specimens were studied as a total. 17.2% of them had various morphological deviations. The most common types of aberrations were observed in the number and positions of genualae I (94 specimens), AM seta (79 spec.) and sternal setae (77 spec.). The aberrations of sternal and coxal setae were usually interrelated: the sternal seta was "transferred" from the sternal area onto the coxa, or the other way round take place. The specimens having aberrations of sternal setae were twice as numerous as the specimens with aberrations of coxal setae (77 against 35). The specimens with aberrations of dorsal setae and mastitarsala were very rare (2 spec. each). Among anomalies, the presence of nude galeal seta (91 spec.) and scutal anomalies (66 spec.) were prevalent. The most frequently one form of deviation only was observed in one specimen of N. sympatrica. Nevertheless, the specimens simultaneously having several aberrations or anomalies were also found. 17 types of such combinations were observed, that counts 20.6% of all specimens with deviations. Symmetric deviations, namely the presence of two nude galeal setae (31 spec.), presence of 2 genualae on both legs I (4 spec.), presence of 2 AM (2 spec.) and symmetric reduction of scutal angles (1 spec.), sometimes cause troubles in diagnostics. The quarter of variance in N. sympatrica and in the species N. monticola Schluger et Davydov, 1967 formerly studied by the author turned out as almost identical. The specimens with deviations counted 14.5% of all studied specimens in the latter species. However, the structures of variance in these species is different. In N. monticola, the aberrations of humeral setae were dominant (71.6%) (Kharadov, Chirov, 2001), while in N. sympatrica, the aberrations of other structures were prevalent: genualae I (24.8%), AM (20.9%) and sternal setae (20.4%).

Augmented Reality for the Improvement of Remote Laboratories: An Augmented Remote Laboratory

ERIC Educational Resources Information Center

Andujar, J. M.; Mejias, A.; Marquez, M. A.

2011-01-01

Augmented reality (AR) provides huge opportunities for online teaching in science and engineering, as these disciplines place emphasis on practical training and unsuited to completely nonclassroom training. This paper proposes a new concept in virtual and remote laboratories: the augmented remote laboratory (ARL). ARL is being tested in the first…

Air Gun Launch Simulation Modeling and Finite Element Model Sensitivity Analysis

DTIC Science & Technology

2006-01-01

Mr. Edward Szymanski, and Mr. William McIntosh of ARL in delivering the air gun test are greatly appreciated. Dr. Dave Hampton of the U.S. Military...ARMY RSCH LABORATORY ATTN AMSRD ARL WM BD P CONROY B FORCH M LEADORE R LIEB B RICE R PESCE RODRIGUEZ A ZIELINSKI BLDG 4600

Usability study of a novel, self-lighted, disposable speculum: military applications.

PubMed

Jones, Christina L; Gruber, Daniel D; Warner, William; Buller, Jerome L

2013-04-01

Data collected from a postutilization questionnaire were used to evaluate the usability of the OfficeSPEC disposable vaginal speculum, specifically the effectiveness, efficiency, and acceptability, in clinical, hospital, and austere environments. Usability data analysis showed the OfficeSPEC speculum had an effectiveness rating of 4.6/5, efficiency rating of 4.5/5, and acceptability rating of 4.6/5; overall usability in deployed environments was favorable. The overall rankings were 3.4 for plastic, 4.2 for metal (p < 0.001), and 4.5 for OfficeSPEC (p < 0.001). Cost analysis of the OfficeSPEC placed the disposable speculum as a reasonable alternative with yearly cost of $129,200, compared to traditional metal ($209,100) and plastic ($319,175). By evaluating the OfficeSPEC speculum within a usability framework, it proved to be practical, viable alternative in all environments, particularly in the forward deployed environment. Reprint & Copyright © 2013 Association of Military Surgeons of the U.S.

Evaluation of Consideration and Incorporation of Green and Sustainable Remediation (GSR) Practices in Army Environmental Remediation. Volume 1

DTIC Science & Technology

2012-08-27

materials Examples: - Cheese whey , molasses, compost, or off-spec food products for inducing anaerobic conditions - Crushed concrete for use as...place of refined chemicals or materials Examples: - Cheese whey , molasses, compost, or off-spec food products for inducing anaerobic conditions... whey , molasses, compost, or off-spec food products for inducing anaerobic conditions - Crushed concrete for use as fill - Concrete from coal

ChinaSpec: a network of SIF observations to bridge flux measurements and remote sensing data

NASA Astrophysics Data System (ADS)

Zhang, Y.; Wang, S.; Liu, L.; Ju, W.; Zhu, X.

2017-12-01

Accurately quantifying atmosphere-biosphere interactions across multiple scale still remains a challenge. Remote sensing, especially satellite data, has been widely used as a solution to resolve the broad scale estimation of carbon flux by upscaling the point measurements of eddy covariance (EC) technique. However, critical gaps remain between the EC observations and coarse satellite data due to the scale mismatch. In this regard, it is necessary to build a network of in situ optical observations to bridge the scale-mismatch between EC measurements and satellite remote sensing data. Internationally, a few networks have already been established (e.g., SpecNet and EuroSpec), but still at its early stage. ChinaSpec is a network of linking in situ spectral measurements, especially sun-induce chlorophyll fluorescence (SIF), with point EC observations for better understanding the interactions of atmosphere-biosphere. One main focus of ChinsSpec is to conduct continuous field SIF measurements at multiple EC sites across the mainland of China. This will help us better understand the mechanics of SIF and photosynthesis, and resolve the missing gaps between recent SIF retrievals from coarse satellite data and EC observations. In this presentation, we introduce the background, current stage, and the development of ChinaSpec network.

SpecViz: Interactive Spectral Data Analysis

NASA Astrophysics Data System (ADS)

Earl, Nicholas Michael; STScI

2016-06-01

The astronomical community is about to enter a new generation of scientific enterprise. With next-generation instrumentation and advanced capabilities, the need has arisen to equip astronomers with the necessary tools to deal with large, multi-faceted data. The Space Telescope Science Institute has initiated a data analysis forum for the creation, development, and maintenance of software tools for the interpretation of these new data sets. SpecViz is a spectral 1-D interactive visualization and analysis application built with Python in an open source development environment. A user-friendly GUI allows for a fast, interactive approach to spectral analysis. SpecViz supports handling of unique and instrument-specific data, incorporation of advanced spectral unit handling and conversions in a flexible, high-performance interactive plotting environment. Active spectral feature analysis is possible through interactive measurement and statistical tools. It can be used to build wide-band SEDs, with the capability of combining or overplotting data products from various instruments. SpecViz sports advanced toolsets for filtering and detrending spectral lines; identifying, isolating, and manipulating spectral features; as well as utilizing spectral templates for renormalizing data in an interactive way. SpecViz also includes a flexible model fitting toolset that allows for multi-component models, as well as custom models, to be used with various fitting and decomposition routines. SpecViz also features robust extension via custom data loaders and connection to the central communication system underneath the interface for more advanced control. Incorporation with Jupyter notebooks via connection with the active iPython kernel allows for SpecViz to be used in addition to a user’s normal workflow without demanding the user drastically alter their method of data analysis. In addition, SpecViz allows the interactive analysis of multi-object spectroscopy in the same straight-forward, consistent way. Through the development of such tools, STScI hopes to unify astronomical data analysis software for JWST and other instruments, allowing for efficient, reliable, and consistent scientific results.

Simple Computation of the Heat of Formation and Density from Theoretically Predicted Values

DTIC Science & Technology

2012-09-01

ARSENAL AL 35898-5249 2 US ARMY AVN & MIS CMND ATTN AMSRD AMR PS PT L PLEDGER ATTN AMSRD AMR PS PT M MORRISON BLDG 7120...REDSTONE ARSENAL AL 35898 2 US ARMY AVN & MIS CMND ATTN AMSRD ARL PS PT G DRAKE ATTN AMSRD ARL PS PT N MATHIS BLDG 7120

Interference Cancellation System Design Using GNU Radio

DTIC Science & Technology

2015-12-01

ARL-TR-7546 ● DEC 2015 US Army Research Laboratory Interference Cancellation System Design Using GNU Radio by Jan Paolo...Interference Cancellation System Design Using GNU Radio by Jan Paolo Acosta Sensors and Electron Devices Directorate, ARL...REPORT DATE (DD-MM-YYYY) December 2015 2. REPORT TYPE Final 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Interference Cancellation System

Android Smartphone Relevance to Military Weather Applications

DTIC Science & Technology

2011-10-01

lithium -ion battery that may be replaced by the user (unlike Apple iPod Touch devices), thus spare batteries can be carried. If there is only sporadic...Android Smartphone Relevance to Military Weather Applications by David Sauter ARL-TR-5793 October 2011...Android Smartphone Relevance to Military Weather Applications David Sauter Computational and Information Sciences Directorate, ARL

Carbon Nanotube Based Flexible Supercapacitors

DTIC Science & Technology

2011-04-01

Carbon Nanotube Based Flexible Supercapacitors by Christopher M. Anton and Matthew H. Ervin ARL-TR-5522 April 2011...Carbon Nanotube Based Flexible Supercapacitors Christopher M. Anton and Matthew H. Ervin Sensors and Electron Devices Directorate, ARL...September 2010 4. TITLE AND SUBTITLE Carbon Nanotube Based Flexible Supercapacitors 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

Three new species of Seira Lubbock (Collembola, Entomobryidae) from Caatinga Domain, northeastern Brazil.

PubMed

Godeiro, Nerivania N; Bellini, Bruno C

2014-02-10

Three new species of Seira Lubbock, Seira jiboiensis sp.nov., Seira primaria sp. nov. and Seira harena sp.nov. from Neotropical Region are described and illustrated. All species were collected from humid areas of Caatinga Biogeographic Domain, northeastern Brazil. Seira jiboiensis sp.nov. shows some similarities with S. mendoncea Bellini & Zeppelini and S. ritae Bellini & Zeppelini, while S. primaria sp.nov. resembles S. pseudoannulata Bellini & Zeppelini and S. paraibensis Bellini & Zeppelini in dorsal chaetotaxy in some aspects. Seira harena sp.nov. belongs to a subgroup of Seira originally described in the subgenus Lepidocyrtinus Börner, which has modified macrochaetae on distal manubrium and proximal dens, like S. prodiga (Arlé), S. xinguensis (Arlé) and S. nigrans (Arlé).

Application of the dynamically allocated virtual clustering management system to emulated tactical network experimentation

NASA Astrophysics Data System (ADS)

Marcus, Kelvin

2014-06-01

The U.S Army Research Laboratory (ARL) has built a "Network Science Research Lab" to support research that aims to improve their ability to analyze, predict, design, and govern complex systems that interweave the social/cognitive, information, and communication network genres. Researchers at ARL and the Network Science Collaborative Technology Alliance (NS-CTA), a collaborative research alliance funded by ARL, conducted experimentation to determine if automated network monitoring tools and task-aware agents deployed within an emulated tactical wireless network could potentially increase the retrieval of relevant data from heterogeneous distributed information nodes. ARL and NS-CTA required the capability to perform this experimentation over clusters of heterogeneous nodes with emulated wireless tactical networks where each node could contain different operating systems, application sets, and physical hardware attributes. Researchers utilized the Dynamically Allocated Virtual Clustering Management System (DAVC) to address each of the infrastructure support requirements necessary in conducting their experimentation. The DAVC is an experimentation infrastructure that provides the means to dynamically create, deploy, and manage virtual clusters of heterogeneous nodes within a cloud computing environment based upon resource utilization such as CPU load, available RAM and hard disk space. The DAVC uses 802.1Q Virtual LANs (VLANs) to prevent experimentation crosstalk and to allow for complex private networks. Clusters created by the DAVC system can be utilized for software development, experimentation, and integration with existing hardware and software. The goal of this paper is to explore how ARL and the NS-CTA leveraged the DAVC to create, deploy and manage multiple experimentation clusters to support their experimentation goals.

MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes.

PubMed

Ardin, Maude; Cahais, Vincent; Castells, Xavier; Bouaoun, Liacine; Byrnes, Graham; Herceg, Zdenko; Zavadil, Jiri; Olivier, Magali

2016-04-18

The nature of somatic mutations observed in human tumors at single gene or genome-wide levels can reveal information on past carcinogenic exposures and mutational processes contributing to tumor development. While large amounts of sequencing data are being generated, the associated analysis and interpretation of mutation patterns that may reveal clues about the natural history of cancer present complex and challenging tasks that require advanced bioinformatics skills. To make such analyses accessible to a wider community of researchers with no programming expertise, we have developed within the web-based user-friendly platform Galaxy a first-of-its-kind package called MutSpec. MutSpec includes a set of tools that perform variant annotation and use advanced statistics for the identification of mutation signatures present in cancer genomes and for comparing the obtained signatures with those published in the COSMIC database and other sources. MutSpec offers an accessible framework for building reproducible analysis pipelines, integrating existing methods and scripts developed in-house with publicly available R packages. MutSpec may be used to analyse data from whole-exome, whole-genome or targeted sequencing experiments performed on human or mouse genomes. Results are provided in various formats including rich graphical outputs. An example is presented to illustrate the package functionalities, the straightforward workflow analysis and the richness of the statistics and publication-grade graphics produced by the tool. MutSpec offers an easy-to-use graphical interface embedded in the popular Galaxy platform that can be used by researchers with limited programming or bioinformatics expertise to analyse mutation signatures present in cancer genomes. MutSpec can thus effectively assist in the discovery of complex mutational processes resulting from exogenous and endogenous carcinogenic insults.

Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings

PubMed Central

Keahey, Pelham A.; Simeral, Mathieu L.; Schroder, Kristofer J.; Bond, Meaghan M.; Mtenthaonnga, Prince J.; Miros, Robert H.; Dube, Queen

2017-01-01

Newborns are at increased risk of jaundice, a condition in which excess bilirubin accumulates in blood. Left untreated, jaundice can lead to neurological impairment and death. Jaundice resulting from unconjugated hyperbilirubinemia is easily treated with exposure to blue light, and phototherapy systems have been developed for low-resource settings; however, there are no appropriate solutions to diagnose and monitor jaundice in these settings. To address this need we present BiliSpec, a low-cost reader and disposable lateral flow card designed to measure the concentration of total bilirubin from several drops of blood at the point of care. We evaluated the performance of BiliSpec, using blood from normal volunteers spiked with varying amounts of bilirubin; results measured using BiliSpec correlated well with a reference laboratory bilirubinometer (r = 0.996). We then performed a pilot clinical study using BiliSpec to measure total bilirubin in neonates at risk for jaundice at Queen Elizabeth Central Hospital in Blantyre, Malawi. Concentrations measured using BiliSpec correlated well with those measured using a laboratory reference standard in 94 patient samples ranging from 1.1 mg/dL to 23.0 mg/dL in concentration (r = 0.973). The mean difference between bilirubin levels measured with BiliSpec and the reference standard was 0.3 mg/dL (95% CI: −1.7–2.2 mg/dL). PMID:29203650

Simultaneous Isolation of Lactoferrin and Lactoperoxidase from Bovine Colostrum by SPEC 70 SLS Cation Exchange Resin

PubMed Central

Liang, Yafei; Wang, Xuewan; Wu, Mianbin; Zhu, Wanping

2011-01-01

In this work, simultaneous isolation of lactoferrin (Lf) and lactoperoxidase (Lp) from defatted bovine colostrum by one-step cation exchange chromatography with SPEC 70 SLS ion-exchange resin was investigated. A RP-HPLC method for Lf and Lp determination was developed and optimized as the following conditions: detection wavelength of 220 nm, flow rate of 1 mL/min and acetonitrile concentration from 25% to 75% within 20 min. The adsorption process of Lf on SPEC 70 SLS resin was optimized using Lf standard as substrate. The maximum static binding capacity of SPEC 70 SLS resin was of 22.0 mg/g resin at 15 °C, pH 7.0 and adsorption time 3 h. The Lf adsorption process could be well described by the Langmuir adsorption isotherm model, with a maximum adsorption capacity of 21.73 mg/g resin at 15 °C. In batch fractionation of defatted colostrum, the binding capacities of SPEC 70 SLS resin for adsorbing Lf and Lp simultaneously under the abovementioned conditions were 7.60 and 6.89 mg/g resin, respectively, both of which were superior to those of CM Sepharose F.F. or SP Sepharose F.F. resins under the same conditions. As a result, SPEC 70 SLS resin was considered as a successful candidate for direct and economic purification of Lf and Lp from defatted colostrum. PMID:22016715

A New Improved and Extended Version of the Multicell Bacterial Simulator gro.

PubMed

Gutiérrez, Martín; Gregorio-Godoy, Paula; Pérez Del Pulgar, Guillermo; Muñoz, Luis E; Sáez, Sandra; Rodríguez-Patón, Alfonso

2017-08-18

gro is a cell programming language developed in Klavins Lab for simulating colony growth and cell-cell communication. It is used as a synthetic biology prototyping tool for simulating multicellular biocircuits and microbial consortia. In this work, we present several extensions made to gro that improve the performance of the simulator, make it easier to use, and provide new functionalities. The new version of gro is between 1 and 2 orders of magnitude faster than the original version. It is able to grow microbial colonies with up to 10 5 cells in less than 10 min. A new library, CellEngine, accelerates the resolution of spatial physical interactions between growing and dividing cells by implementing a new shoving algorithm. A genetic library, CellPro, based on Probabilistic Timed Automata, simulates gene expression dynamics using simplified and easy to compute digital proteins. We also propose a more convenient language specification layer, ProSpec, based on the idea that proteins drive cell behavior. CellNutrient, another library, implements Monod-based growth and nutrient uptake functionalities. The intercellular signaling management was improved and extended in a library called CellSignals. Finally, bacterial conjugation, another local cell-cell communication process, was added to the simulator. To show the versatility and potential outreach of this version of gro, we provide studies and novel examples ranging from synthetic biology to evolutionary microbiology. We believe that the upgrades implemented for gro have made it into a powerful and fast prototyping tool capable of simulating a large variety of systems and synthetic biology designs.

HPC Insights, Fall 2011

DTIC Science & Technology

2011-01-01

Simulating Satellite Tracking Using Parallel Computing By Andrew Lindstrom ,University of Hawaii at Hilo — Mentors: Carl Holmberg, Maui High Performance...RDECOM) and his management team, RDECOM Deputy Director Gary Martin ; ARL Director John Miller; Communications- Electronics Research, Development...Saves Resources By Mike Knowles, ARL DSRC Site Lead, Lockheed Martin mode instead of full power down. The first phase of the EAS effort is an attempt

Effect of Cleanliness on Hydrogen Tolerance in High-Strength Steel

DTIC Science & Technology

2014-04-01

in High-Strength Steel 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Scott M. Grendahl, Franklyn Kellogg ,* and...Effect of Cleanliness on Hydrogen Tolerance in High-Strength Steel by Scott M. Grendahl, Franklyn Kellogg , and Hoang Nguyen ARL-TR...Directorate, ARL Franklyn Kellogg and Hoang Nguyen Bowhead Technical Services Approved for public

Graphene-based Nanoelectronics

DTIC Science & Technology

2013-02-01

Kong, Pablo Jarillo-Herrero, Mildred Dresselhaus, Pulickel M. Ajayan, Leela Mohana Reddy Arava, and Paresh Ray ARL-TR-6351 February 2013...Jing Kong, Pablo Jarillo-Herrero, and Mildred Dresselhaus Massachusetts Institute of Technology Pulickel M. Ajayan and Leela Mohana Reddy Arava...Herrero, Mildred Dresselhaus, Pulickel M. Ajayan, Leela Mohana Reddy Arava, and Paresh Ray 5d. PROJECT NUMBER ARL DSI-FY-11 5e. TASK NUMBER

Good Practice and Recommendations for Research Team Leadership

DTIC Science & Technology

2017-05-01

ARL-SR-0372 ● MAY 2017 US Army Research Laboratory Good Practice and Recommendations for Research Team Leadership by Mark L...Do not return it to the originator. ARL-SR-0372 ● MAY 2017 US Army Research Laboratory Good Practice and Recommendations for...information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services , Directorate for Information

Bone Conduction Communication: Research Progress and Directions

DTIC Science & Technology

2017-08-16

ARL-TR-8096 ● AUG 2017 US Army Research Laboratory Bone Conduction Communication: Research Progress and Directions by Maranda...this report when it is no longer needed. Do not return it to the originator. ARL-TR-8096 ● AUG 2017 US Army Research Laboratory...Bone Conduction Communication: Research Progress and Directions by Maranda McBride North Carolina Agricultural and Technical State University

Methods for Analysis and Simulation of Ballistic Impact

DTIC Science & Technology

2017-04-01

ARL-RP-0597 ● Apr 2017 US Army Research Laboratory Methods for Analysis and Simulation of Ballistic Impact by John D Clayton...Laboratory Methods for Analysis and Simulation of Ballistic Impact by John D Clayton Weapons and Materials Research Directorate, ARL...analytical, and numerical methods of ballistics research . Similar lengthy references dealing with pertinent aspects include [8, 9]. In contrast, the

Accurate Arabic Script Language/Dialect Classification

DTIC Science & Technology

2014-01-01

Army Research Laboratory Accurate Arabic Script Language/Dialect Classification by Stephen C. Tratz ARL-TR-6761 January 2014 Approved for public...1197 ARL-TR-6761 January 2014 Accurate Arabic Script Language/Dialect Classification Stephen C. Tratz Computational and Information Sciences...Include area code) Standard Form 298 (Rev. 8/98) Prescribed by ANSI Std. Z39.18 January 2014 Final Accurate Arabic Script Language/Dialect Classification

Network Science Research Laboratory (NSRL) Discrete Event Toolkit

DTIC Science & Technology

2016-01-01

ARL-TR-7579 ● JAN 2016 US Army Research Laboratory Network Science Research Laboratory (NSRL) Discrete Event Toolkit by...Laboratory (NSRL) Discrete Event Toolkit by Theron Trout and Andrew J Toth Computational and Information Sciences Directorate, ARL...Research Laboratory (NSRL) Discrete Event Toolkit 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Theron Trout

Assessing the Minimum Number of Synchronization Triggers Necessary for Temporal Variance Compensation in Commercial Electroencephalography (EEG) Systems

DTIC Science & Technology

2012-09-01

by the ARL Translational Neuroscience Branch. It covers the Emotiv EPOC,6 Advanced Brain Monitoring (ABM) B-Alert X10,7 Quasar 8 DSI helmet-based...Systems; ARL-TR-5945; U.S. Army Research Laboratory: Aberdeen Proving Ground, MD, 2012 4 Ibid. 5 Ibid. 6 EPOC is a trademark of Emotiv . 7 B

Tactical Airspace Integration System Situation Awareness Integration Into the Cockpit: Phase 2

DTIC Science & Technology

2013-03-01

ARL-TR-6371 March 2013 prepared by U.S. Army Research Laboratory Human Research and Engineering Directorate (AMCOM Field...Situation Awareness Integration Into the Cockpit: Phase II Michael Sage Jessee and Anthony Morris Human Research and Engineering Directorate, ARL...prepared by U.S. Army Research Laboratory Human Research and Engineering Directorate (AMCOM Field Element) Bldg 5400, Room C236

Personal Academic Strategies for Success (PASS) Tool Administrator’s User Manual

DTIC Science & Technology

2013-12-01

Personal Academic Strategies for Success (PASS) Tool Administrator’s User Manual by Jim H. Hewson, Valerie J. Rice, and Petra Alfred ARL...SR-275 December 2013 Personal Academic Strategies for Success (PASS) Tool Administrator’s User Manual Jim H. Hewson Career Management...Associates ( CMA ) Valerie J. Rice and Petra Alfred Human Research and Engineering Directorate, ARL

Testing the Data Assimilation Capability of the Profiler Virtual Module

DTIC Science & Technology

2016-02-01

ARL-TR-7601 ● FEB 2016 US Army Research Laboratory Testing the Data Assimilation Capability of the Profiler Virtual Module by...originator. ARL-TR-7601 ● FEB 2016 US Army Research Laboratory Testing the Data Assimilation Capability of the Profiler Virtual...hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and

Percentiles of the run-length distribution of the Exponentially Weighted Moving Average (EWMA) median chart

NASA Astrophysics Data System (ADS)

Tan, K. L.; Chong, Z. L.; Khoo, M. B. C.; Teoh, W. L.; Teh, S. Y.

2017-09-01

Quality control is crucial in a wide variety of fields, as it can help to satisfy customers’ needs and requirements by enhancing and improving the products and services to a superior quality level. The EWMA median chart was proposed as a useful alternative to the EWMA \\bar{X} chart because the median-type chart is robust against contamination, outliers or small deviation from the normality assumption compared to the traditional \\bar{X}-type chart. To provide a complete understanding of the run-length distribution, the percentiles of the run-length distribution should be investigated rather than depending solely on the average run length (ARL) performance measure. This is because interpretation depending on the ARL alone can be misleading, as the process mean shifts change according to the skewness and shape of the run-length distribution, varying from almost symmetric when the magnitude of the mean shift is large, to highly right-skewed when the process is in-control (IC) or slightly out-of-control (OOC). Before computing the percentiles of the run-length distribution, optimal parameters of the EWMA median chart will be obtained by minimizing the OOC ARL, while retaining the IC ARL at a desired value.

Practical use of a framework for network science experimentation

NASA Astrophysics Data System (ADS)

Toth, Andrew; Bergamaschi, Flavio

2014-06-01

In 2006, the US Army Research Laboratory (ARL) and the UK Ministry of Defence (MoD) established a collaborative research alliance with academia and industry, called the International Technology Alliance (ITA)1 In Network and Information Sciences, to address fundamental issues concerning Network and Information Sciences that will enhance decision making for coalition operations and enable rapid, secure formation of ad hoc teams in coalition environments and enhance US and UK capabilities to conduct coalition warfare. Research conducted under the ITA was extended through collaboration between ARL and IBM UK to characterize and dene a software stack and tooling that has become the reference framework for network science experimentation in support for validation of theoretical research. This paper discusses the composition of the reference framework for experimentation resulting from the ARL/IBM UK collaboration and its use, by the Network Science Collaborative Technology Alliance (NS CTA)2 , in a recent network science experiment conducted at ARL. It also discusses how the experiment was modeled using the reference framework, the integration of two new components, the Apollo Fact-Finder3 tool and the Medusa Crowd Sensing4 application, the limitations identified and how they shall be addressed in future work.

Seeing the light: The SpecUP educational spectrophotometer

NASA Astrophysics Data System (ADS)

Forbes, P. B. C.

2016-09-01

Spectrophotometry is a cross-cutting analytical technique, which finds use in disciplines ranging from chemistry to pharmacy, biochemistry, food science and physics. The SpecUP (Spectrophotometer of the University of Pretoria) is an educational spectrophotometer which was developed so that students could build their own instruments from components in a kit, and then utilise it to generate analytically useful results. This initiative allows for institutions to have more spectroscopy equipment available, as the SpecUP costs less than 40 as opposed to 2 000 which is the cost of an entry-level commercial instrument. This is of particular importance in a developing country context, where student numbers are typically high and resources are scarce. In addition, the SpecUP has moving parts and an open design which allows users to understand what is inside the "black box" of commercial instruments and to discover what happens when they adjust components, allowing for active, inquiry-based learning. The SpecUP user network currently spans South Africa, Tunisia, Namibia, Lesotho, Botswana, Kenya, Swaziland, Zimbabwe, Zambia, Ivory Coast, Egypt, Turkey and Italy.

Designing Specification Languages for Process Control Systems: Lessons Learned and Steps to the Future

NASA Technical Reports Server (NTRS)

Leveson, Nancy G.; Heimdahl, Mats P. E.; Reese, Jon Damon

1999-01-01

Previously, we defined a blackbox formal system modeling language called RSML (Requirements State Machine Language). The language was developed over several years while specifying the system requirements for a collision avoidance system for commercial passenger aircraft. During the language development, we received continual feedback and evaluation by FAA employees and industry representatives, which helped us to produce a specification language that is easily learned and used by application experts. Since the completion of the PSML project, we have continued our research on specification languages. This research is part of a larger effort to investigate the more general problem of providing tools to assist in developing embedded systems. Our latest experimental toolset is called SpecTRM (Specification Tools and Requirements Methodology), and the formal specification language is SpecTRM-RL (SpecTRM Requirements Language). This paper describes what we have learned from our use of RSML and how those lessons were applied to the design of SpecTRM-RL. We discuss our goals for SpecTRM-RL and the design features that support each of these goals.

Design and Performance of A High Resolution Micro-Spec: An Integrated Sub-Millimeter Spectrometer

NASA Technical Reports Server (NTRS)

Barrentine, Emily M.; Cataldo, Giuseppe; Brown, Ari D.; Ehsan, Negar; Noroozian, Omid; Stevenson, Thomas R.; U-Yen, Kongpop; Wollack, Edward J.; Moseley, S. Harvey

2016-01-01

Micro-Spec is a compact sub-millimeter (approximately 100 GHz--1:1 THz) spectrometer which uses low loss superconducting microstrip transmission lines and a single-crystal silicon dielectric to integrate all of the components of a diffraction grating spectrometer onto a single chip. We have already successfully evaluated the performance of a prototype Micro-Spec, with spectral resolving power, R=64. Here we present our progress towards developing a higher resolution Micro-Spec, which would enable the first science returns in a balloon flight version of this instrument. We describe modifications to the design in scaling from a R=64 to a R=256 instrument, as well as the ultimate performance limits and design concerns when scaling this instrument to higher resolutions.

Catalog of candidates for quasars at 3 < z < 5.5 selected among X-Ray sources from the 3XMM-DR4 survey of the XMM-Newton observatory

NASA Astrophysics Data System (ADS)

Khorunzhev, G. A.; Burenin, R. A.; Meshcheryakov, A. V.; Sazonov, S. Yu.

2016-05-01

We have compiled a catalog of 903 candidates for type 1 quasars at redshifts 3 < z < 5.5 selected among the X-ray sources of the "serendipitous" XMM-Newton survey presented in the 3XMMDR4 catalog (the median X-ray flux is ≈5 × 10-15 erg s-1 cm-2 in the 0.5-2 keV energy band) and located at high Galactic latitudes | b| > 20° in Sloan Digital Sky Survey (SDSS) fields with a total area of about 300 deg2. Photometric SDSS data as well infrared 2MASS and WISE data were used to select the objects. We selected the point sources from the photometric SDSS catalog with a magnitude error δ mz' < 0.2 and a color i' - z' < 0.6 (to first eliminate the M-type stars). For the selected sources, we have calculated the dependences χ2( z) for various spectral templates from the library that we compiled for these purposes using the EAZY software. Based on these data, we have rejected the objects whose spectral energy distributions are better described by the templates of stars at z = 0 and obtained a sample of quasars with photometric redshift estimates 2.75 < z phot < 5.5. The selection completeness of known quasars at z spec > 3 in the investigated fields is shown to be about 80%. The normalized median absolute deviation (Δ z = | z spec - z phot|) is σ Δ z /(1+ z spec) = 0.07, while the outlier fraction is η = 9% when Δ z/(1 + z cпek.) > 0.2. The number of objects per unit area in our sample exceeds the number of quasars in the spectroscopic SDSS sample at the same redshifts approximately by a factor of 1.5. The subsequent spectroscopic testing of the redshifts of our selected candidates for quasars at 3 < z < 5.5 will allow the purity of this sample to be estimated more accurately.

Engineering and Design. Containment and Disposal of Aqueous Film-Forming Foam Solution

DTIC Science & Technology

1997-05-23

Aqueous Film-Forming Foam (AFFF) concentrate used in DoD facilities must be "MIL-SPEC" foam conforming to MIL - F - 24385 . MIL-SPEC foam is recognized...requirements, the MIL - F - 24385 provides for important chemical and physical properties not specified by other standards. "MIL-SPEC" AFFF concentrate...is the standard by which others are measured. Other commercially available AFFF concentrates are simply not comparable to those conforming to MIL - F - 24385 . 3.2

Evaluation of a Prototype Low-Cost, Modular, Wireless Electroencephalography (EEG) Headset Design for Widespread Application

DTIC Science & Technology

2016-06-01

therefore did not implement or test actual sensors or electronic components (analog-to-digital conversion, power , and the wireless transmission ...ARL-TR-7703 ● JUNE 2016 US Army Research Laboratory Evaluation of a Prototype Low-Cost, Modular, Wireless Electroencephalography...originator. ARL-TR-7703 ● JUNE 2016 US Army Research Laboratory Evaluation of a Prototype Low-Cost, Modular, Wireless

Setup Instructions for the Applied Anomaly Detection Tool (AADT) Web Server

DTIC Science & Technology

2016-09-01

ARL-TR-7798 ● SEP 2016 US Army Research Laboratory Setup Instructions for the Applied Anomaly Detection Tool (AADT) Web Server...for the Applied Anomaly Detection Tool (AADT) Web Server by Christian D Schlesiger Computational and Information Sciences Directorate, ARL...SUBTITLE Setup Instructions for the Applied Anomaly Detection Tool (AADT) Web Server 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine Applications

DTIC Science & Technology

2015-09-01

ARL-RP-0551 ● SEP 2015 US Army Research Laboratory Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine...ARL-RP-0551 ● SEP 2015 US Army Research Laboratory Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine Applications by...COVERED (From - To) 1 January 2014–30 September 2014 4. TITLE AND SUBTITLE Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine

Complex Event Processing for Content-Based Text, Image, and Video Retrieval

DTIC Science & Technology

2016-06-01

NY): Wiley- Interscience; 2000. Feldman R, Sanger J. The text mining handbook: advanced approaches in analyzing unstructured data. New York (NY...ARL-TR-7705 ● JUNE 2016 US Army Research Laboratory Complex Event Processing for Content-Based Text , Image, and Video Retrieval...ARL-TR-7705 ● JUNE 2016 US Army Research Laboratory Complex Event Processing for Content-Based Text , Image, and Video Retrieval

Warriors Edge Simulation and Gaming System: The Squad Simulation

DTIC Science & Technology

2005-08-01

Warriors Edge Simulation and Gaming System: The Squad Simulation by Mark Thomas and Gary Moss ARL-TR-3564 August 2005...Edge Simulation and Gaming System: The Squad Simulation Mark Thomas and Gary Moss Computational and Information Sciences Directorate, ARL...2004–30 September 2004 5a. CONTRACT NUMBER 5b. GRANT NUMBER 4. TITLE AND SUBTITLE Warriors Edge Simulation and Gaming System: The Squad

Aural-Nondetectability Model Predictions for Night-Vision Goggles across Ambient Lighting Conditions

DTIC Science & Technology

2015-12-01

ARL-TR-7564 ● DEC 2015 US Army Research Laboratory Aural-Nondetectability Model Predictions for Night -Vision Goggles across...ARL-TR-7564 ● DEC 2015 US Army Research Laboratory Aural-Nondetectability Model Predictions for Night -Vision Goggles across Ambient...May 2015–30 Sep 2015 4. TITLE AND SUBTITLE Aural-Nondetectability Model Predictions for Night -Vision Goggles across Ambient Lighting Conditions 5a

Characterization of Cyclohexanone Inclusions in Class 1 RDX

DTIC Science & Technology

2014-06-01

characterized with respect to solvent inclusions in support of a U.S. Army Research Laboratory (ARL) program to model Multiscale Response of Energetic...pertinent to their modeling effort under the Multiscale Response of Energetic Materials (MREM) program, and the Weapons and Materials Research...support of a U.S. Army Research Laboratory (ARL) initiative called “ Multiscale Modeling of Energetic Materials” (MREM). The MREM program aims, for

Gas Metal Arc Weld (GMAW) Qualification of 7020-T651 Aluminum

DTIC Science & Technology

2015-11-01

ARL-TR-7515 ● NOV 2015 US Army Research Laboratory Gas Metal Arc Weld (GMAW) Qualification of 7020-T651 Aluminum by John F...Metal Arc Weld (GMAW) Qualification of 7020-T651 Aluminum by John F Chinella Weapons and Materials Research Directorate, ARL Nick Kapustka and...Seth Shira Edison Welding Institute, Columbus, Ohio Approved for public release; distribution is unlimited. ii REPORT

An Automated Energy Detection Algorithm Based on Kurtosis-Histogram Excision

DTIC Science & Technology

2018-01-01

ARL-TR-8269 ● JAN 2018 US Army Research Laboratory An Automated Energy Detection Algorithm Based on Kurtosis-Histogram Excision...needed. Do not return it to the originator. ARL-TR-8269 ● JAN 2018 US Army Research Laboratory An Automated Energy Detection...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources

Numeric Computation of the Radar Cross Section of In-flight Projectiles

DTIC Science & Technology

2016-11-01

SUBJECT TERMS computational electromagnetics , radar signature, ballistic trajectory, radar cross section, RCS 16. SECURITY CLASSIFICATION OF: 17...under the generic category of rockets, artillery, and mortar (RAM). The electromagnetic (EM) modeling team at the US Army Research Laboratory (ARL) is...ARL-TR-5145. 5. Balanis C. Advanced engineering electromagnetics . New York (NY): Wiley; 1989. 6. Ruck G, Barrick DE, Stuart WD, Krichbaum CK

U.S. Army Toxic Metal Reduction Program: Demonstrating Alternatives to Hexavalent Chromium and Cadmium in Surface Finishing

DTIC Science & Technology

2014-11-18

only) Medium Cal: M242 25mm Bushmaster, M230 30mm, GAU-12 25mm, 30mm Bushmaster II, EAPS 50mm POC: Vic Champagne , ARL, victor.k.champagne.civ...Shielding for Electronic Shelters) POC: Vic Champagne , ARL, victor.k.champagne.civ@mail.mil Cold Spray – Portable System and Internal Diameter

Radar Array Processing of Experimental Data Via the Scan-MUSIC Algorithm

DTIC Science & Technology

2004-06-01

Radar Array Processing of Experimental Data Via the Scan- MUSIC Algorithm by Canh Ly ARL-TR-3135 June 2004...Processing of Experimental Data Via the Scan- MUSIC Algorithm Canh Ly Sensors and Electron Devices Directorate, ARL...NUMBER 5b. GRANT NUMBER 4. TITLE AND SUBTITLE Radar Array Processing of Experimental Data Via the Scan- MUSIC Algorithm 5c. PROGRAM ELEMENT NUMBER 5d

Research in free-flying robots and flexible manipulators at the Stanford Aerospace Robotics Laboratory

NASA Technical Reports Server (NTRS)

Ballhaus, W. L.; Alder, L. J.; Chen, V. W.; Dickson, W. C.; Ullman, M. A.; Wilson, E.

1993-01-01

Over the last ten years, the Stanford Aerospace Robotics Laboratory (ARL) has developed a hardware facility in which a number of space robotics issues have been, and continue to be addressed. This paper reviews two of the current ARL research areas: navigation and control of free flying space robots, and modeling and control of extremely flexible space structures.

Visualizing Energy on Target: Molecular Dynamics Simulations

DTIC Science & Technology

2017-12-01

ARL-TR-8234 ● DEC 2017 US Army Research Laboratory Visualizing Energy on Target: Molecular Dynamics Simulations by DeCarlos E...return it to the originator. ARL-TR-8234● DEC 2017 US Army Research Laboratory Visualizing Energy on Target: Molecular Dynamics...REPORT TYPE Technical Report 3. DATES COVERED (From - To) 1 October 2015–30 September 2016 4. TITLE AND SUBTITLE Visualizing Energy on Target

An Automated Energy Detection Algorithm Based on Morphological and Statistical Processing Techniques

DTIC Science & Technology

2018-01-09

ARL-TR-8272 ● JAN 2018 US Army Research Laboratory An Automated Energy Detection Algorithm Based on Morphological and...is no longer needed. Do not return it to the originator. ARL-TR-8272 ● JAN 2018 US Army Research Laboratory An Automated Energy ...4. TITLE AND SUBTITLE An Automated Energy Detection Algorithm Based on Morphological and Statistical Processing Techniques 5a. CONTRACT NUMBER

Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition

DTIC Science & Technology

2015-09-01

ARL-CR-0783 ● SEP 2015 US Army Research Laboratory Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid...ARL-CR-0783 ● SEP 2015 US Army Research Laboratory Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle...Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition 5a. CONTRACT NUMBER 1120-1120-99 5b. GRANT NUMBER 5c

Reference Proteome Extracts for Mass Spec Instrument Performance Validation and Method Development

PubMed Central

Rosenblatt, Mike; Urh, Marjeta; Saveliev, Sergei

2014-01-01

Biological samples of high complexity are required to test protein mass spec sample preparation procedures and validate mass spec instrument performance. Total cell protein extracts provide the needed sample complexity. However, to be compatible with mass spec applications, such extracts should meet a number of design requirements: compatibility with LC/MS (free of detergents, etc.)high protein integrity (minimal level of protein degradation and non-biological PTMs)compatibility with common sample preparation methods such as proteolysis, PTM enrichment and mass-tag labelingLot-to-lot reproducibility Here we describe total protein extracts from yeast and human cells that meet the above criteria. Two extract formats have been developed: Intact protein extracts with primary use for sample preparation method development and optimizationPre-digested extracts (peptides) with primary use for instrument validation and performance monitoring

Soil Ciliates from Saudi Arabia, Including Descriptions of Two New Genera and Six New Species.

PubMed

Foissner, Wilhelm; Quintela-Alonso, Pablo; Al-Rasheid, Khaled

2008-01-01

Six soil samples from natural and cultivated sites of Saudi Arabia were investigated for ciliate diversity, using the non-flooded Petri dish culture method, live observation, and silver impregnation. We identified 135 species, all new for the fauna of Saudi Arabia, of which seven were undescribed: Spathidium alqasabi nov. spec.; Enchelyodon alqasabi nov. spec.; Metauroleptus arabicus nov. gen., nov. spec.; Pseudohemisincirra arabica nov. gen., nov. spec.; Saudithrix terricola​ Berger, Al-Rasheid and Foissner, 2006; Oxytricha arabica nov. spec.; and Erimophrya monostyla nov. spec. Based on Spathidium alqasabi, S. seppelti foissneri​ Vd'ačný et al., 2006 and S. seppelti etoschense​ Foissner et al., 2002 are raised to species rank; for the latter, a new name is required to avoid homonymy: Spathidium fraterculum nov. nom. The new genus Metauroleptus, which possesses two long and two to three short ventral cirral rows, generates all dorsal kineties intrakinetally and produces caudal cirri exclusively in dorsal kinety 1. Metauroleptus belongs to the hypotrichs, while family classification remains doubtful. The same applies to the new hypotrich genus Pseudohemisincirra, which has frontoventral and transverse cirri, while buccal cirri and caudal cirri are absent. The number of species contained in Saudi Arabian soils, including sand dunes, is in the range reported from other regions of the earth, suggesting that ciliates are well adapted to dry habitats, possibly mainly by their ability to produce very resistant resting cysts, most surviving for a long time due to reduced metazoan predation.

SuperSpec, The On-Chip Spectrometer: Improved NEP and Antenna Performance

NASA Astrophysics Data System (ADS)

Wheeler, Jordan; Hailey-Dunsheath, S.; Shirokoff, E.; Barry, P. S.; Bradford, C. M.; Chapman, S.; Che, G.; Doyle, S.; Glenn, J.; Gordon, S.; Hollister, M.; Kovács, A.; LeDuc, H. G.; Mauskopf, P.; McGeehan, R.; McKenney, C.; Reck, T.; Redford, J.; Ross, C.; Shiu, C.; Tucker, C.; Turner, J.; Walker, S.; Zmuidzinas, J.

2018-05-01

SuperSpec is a new technology for mm and sub-mm spectroscopy. It is an on-chip spectrometer being developed for multi-object, moderate-resolution (R˜ 300 ), large bandwidth survey spectroscopy of high-redshift galaxies for the 1 mm atmospheric window. This band accesses the CO ladder in the redshift range of z = 0-4 and the [CII] 158 μm line from redshift z = 5-9. SuperSpec employs a novel architecture in which detectors are coupled to a series of resonant filters along a single microwave feedline instead of using dispersive optics. This construction allows for the creation of a full spectrometer occupying only ˜ 10 cm^2 of silicon, a reduction in size of several orders of magnitude when compared to standard grating spectrometers. This small profile enables the production of future multi-beam spectroscopic instruments envisioned for the millimeter band to measure the redshifts of dusty galaxies efficiently. The SuperSpec collaboration is currently pushing toward the deployment of a SuperSpec demonstration instrument in fall of 2018. The progress with the latest SuperSpec prototype devices is presented; reporting increased responsivity via a reduced inductor volume (2.6 μm^3 ) and the incorporation of a new broadband antenna. A detector NEP of 3-4 × 10^{-18} W/Hz^{0.5} is obtained, sufficient for background-limited observation on mountaintop sites. In addition, beam maps and efficiency measurements of a new wide-band dual bow-tie slot antenna are shown.

[Acquired immunodeficiency syndrome-related lymphoma: 1. Course during the 20 years of the epidemic. 2. The experience at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán: 1986-2003].

PubMed

Hernández-Rivera, E Gabriela; Gómez-Roel, Xóchitl; Villasís-Keever, Angelina

2004-01-01

The goal of this presentation is the description of the epidemiologic evolution and changes in natural history of the human immunodeficiency virus infection (HIV) epidemic itself and its relation with the acquired immunodeficiency syndrome-related lymphoma (ARL). We have started with the description of the world's state of the HIV epidemic, its features since the first case report in the United States of America in 1981, through the peak of new diagnoses in 1993 until the event that changed the natural history of the disease: the era of the widespread use of the highly active antiretroviral therapy (HAART), introduced in 1995 in the world and in 1997 in our country. The widespread introduction of HAART led to dramatic reductions in AIDS related mortality and morbidity throughout the developed world with a marked fall in the incidence of the major opportunistic infections in AIDS. We describe the main risk factors for the development of ARL, and the prognostic factors for survival and response to treatment. There is no clear definition in the literature of the roll that has played the use of HAART in relation to survival and response to treatment in ARL, but there is evidence that the basal count of CD4 cells has increased with HAART, leading to a better survival and response in ARL. The debate regarding this issue is surely affected by factors such as degree of antiretroviral treatment compliance, antiretroviral therapy resistance and chemotherapy heterogeneity. Finally we present the preliminary results of the analysis of our experience in ARL from 1986 to 2003.

Permeability of PEGylated immunoarsonoliposomes through in vitro blood brain barrier-medulloblastoma co-culture models for brain tumor therapy.

PubMed

Al-Shehri, Abdulghani; Favretto, Marco E; Ioannou, Panayiotis V; Romero, Ignacio A; Couraud, Pierre-Olivier; Weksler, Babette Barbash; Parker, Terry L; Kallinteri, Paraskevi

2015-03-01

Owing to restricted access of pharmacological agents into the brain due to blood brain barrier (BBB) there is a need: 1. to develop a more representative 3-D-co-culture model of tumor-BBB interaction to investigate drug and nanoparticle transport into the brain for diagnostic and therapeutic evaluation. 2. to address the lack of new alternative methods to animal testing according to replacement-reduction-refinement principles. In this work, in vitro BBB-medulloblastoma 3-D-co-culture models were established using immortalized human primary brain endothelial cells (hCMEC/D3). hCMEC/D3 cells were cultured in presence and in absence of two human medulloblastoma cell lines on Transwell membranes. In vitro models were characterized for BBB formation, zonula occludens-1 expression and permeability to dextran. Transferrin receptors (Tfr) expressed on hCMEC/D3 were exploited to facilitate arsonoliposome (ARL) permeability through the BBB to the tumor by covalently attaching an antibody specific to human Tfr. The effect of anticancer ARLs on hCMEC/D3 was assessed. In vitro BBB and BBB-tumor co-culture models were established successfully. BBB permeability was affected by the presence of tumor aggregates as suggested by increased permeability of ARLs. There was a 6-fold and 8-fold increase in anti-Tfr-ARL uptake into VC312R and BBB-DAOY co-culture models, respectively, compared to plain ARLs. The three-dimensional models might be appropriate models to study the transport of various drugs and nanocarriers (liposomes and immunoarsonoliposomes) through the healthy and diseased BBB. The immunoarsonoliposomes can be potentially used as anticancer agents due to good tolerance of the in vitro BBB model to their toxic effect.

FOCU:S--future operator control unit: soldier

NASA Astrophysics Data System (ADS)

O'Brien, Barry J.; Karan, Cem; Young, Stuart H.

2009-05-01

The U.S. Army Research Laboratory's (ARL) Computational and Information Sciences Directorate (CISD) has long been involved in autonomous asset control, specifically as it relates to small robots. Over the past year, CISD has been making strides in the implementation of three areas of small robot autonomy, namely platform autonomy, Soldier-robot interface, and tactical behaviors. It is CISD's belief that these three areas must be considered as a whole in order to provide Soldiers with useful capabilities. In addressing the Soldier-robot interface aspect, CISD has begun development on a unique dismounted controller called the Future Operator Control Unit: Soldier (FOCU:S) that is based on an Apple iPod Touch. The iPod Touch's small form factor, unique touch-screen input device, and the presence of general purpose computing applications such as a web browser combine to give this device the potential to be a disruptive technology. Setting CISD's implementation apart from other similar iPod or iPhone-based devices is the ARL software that allows multiple robotic platforms to be controlled from a single OCU. The FOCU:S uses the same Agile Computing Infrastructure (ACI) that all other assets in the ARL robotic control system use, enabling automated asset discovery on any type of network. Further, a custom ad hoc routing implementation allows the FOCU:S to communicate with the ARL ad hoc communications system and enables it to extend the range of the network. This paper will briefly describe the current robotic control architecture employed by ARL and provide short descriptions of existing capabilities. Further, the paper will discuss FOCU:S specific software developed for the iPod Touch, including unique capabilities enabled by the device's unique hardware.

Sensors, nano-electronics and photonics for the Army of 2030 and beyond

NASA Astrophysics Data System (ADS)

Perconti, Philip; Alberts, W. C. K.; Bajaj, Jagmohan; Schuster, Jonathan; Reed, Meredith

2016-02-01

The US Army's future operating concept will rely heavily on sensors, nano-electronics and photonics technologies to rapidly develop situational understanding in challenging and complex environments. Recent technology breakthroughs in integrated 3D multiscale semiconductor modeling (from atoms-to-sensors), combined with ARL's Open Campus business model for collaborative research provide a unique opportunity to accelerate the adoption of new technology for reduced size, weight, power, and cost of Army equipment. This paper presents recent research efforts on multi-scale modeling at the US Army Research Laboratory (ARL) and proposes the establishment of a modeling consortium or center for semiconductor materials modeling. ARL's proposed Center for Semiconductor Materials Modeling brings together government, academia, and industry in a collaborative fashion to continuously push semiconductor research forward for the mutual benefit of all Army partners.

Texture analysis at neutron diffractometer STRESS-SPEC

NASA Astrophysics Data System (ADS)

Brokmeier, H.-G.; Gan, W. M.; Randau, C.; Völler, M.; Rebelo-Kornmeier, J.; Hofmann, M.

2011-06-01

In response to the development of new materials and the application of materials and components in advanced technologies, non-destructive measurement methods of textures and residual stresses have gained worldwide significance in recent years. The materials science neutron diffractometer STRESS-SPEC at FRM II (Garching, Germany) is designed to be applied equally to texture and residual stress analyses by virtue of its very flexible configuration. Due to the high penetration capabilities of neutrons and the high neutron flux of STRESS-SPEC it allows a combined analysis of global texture, local texture, strain pole figure and FWHM pole figure in a wide variety of materials including metals, alloys, composites, ceramics and geological materials. Especially, the analysis of texture gradients in bulk materials using neutron diffraction has advantages over laboratory X-rays and EBSD for many scientific cases. Moreover, neutron diffraction is favourable for coarse-grained materials, where bulk information averaged over texture inhomogeneities is needed, and also stands out due to easy sample preparation. In future, the newly developed robot system for STRESS-SPEC will allow much more flexibility than an Eulerian cradle as on standard instruments. Five recent measurements are shown to demonstrate the wide range of possible texture applications at STRESS-SPEC diffractometer.

Studying Star and Planet Formation with the Submillimeter Probe of the Evolution of Cosmic Structure

NASA Technical Reports Server (NTRS)

Rinehart, Stephen A.

2005-01-01

The Submillimeter Probe of the Evolution of Cosmic Structure (SPECS) is a far- infrared/submillimeter (40-640 micrometers) spaceborne interferometry concept, studied through the NASA Vision Missions program. SPECS is envisioned as a 1-km baseline Michelson interferometer with two 4- meter collecting mirrors. To maximize science return, SPECS will have three operational modes: a photometric imaging mode, an intermediate spectral resolution mode (R approximately equal to 1000-3000), and a high spectral resolution mode (R approximately equal to 3 x 10(exp 5)). The first two of these modes will provide information on all sources within a 1 arcminute field-of-view (FOV), while the the third will include sources in a small (approximately equal to 5 arcsec) FOV. With this design, SPECS will have angular resolution comparable to the Hubble Space Telescope (50 mas) and sensitivity more than two orders of magnitude better than Spitzer (5sigma in 10ks of approximately equal to 3 x 10(exp 7) Jy Hz). We present here some of the results of the recently-completed Vision Mission Study for SPECS, and discuss the application of this mission to future studies of star and planet formation.

Second-generation Micro-Spec: a medium-resolution spectrometer-on-a-chip for submillimeter astronomy

NASA Astrophysics Data System (ADS)

Cataldo, Giuseppe; Barrentine, Emily M.; Bulcha, Berhanu T.; Ehsan, Negar; Hess, Larry A.; Noroozian, Omid; Stevenson, Thomas R.; U-Yen, Kongpop; Wollack, Edward; Moseley, Samuel Harvey

2018-01-01

This work reports on the design of a second-generation Micro-Spec (µ-Spec), a direct-detection spectrometer which integrates all the components of a diffraction-grating spectrometer onto a ~10-cm2 chip by means of superconducting microstrip transmission lines on a monocrystalline silicon substrate. The second-generation µ-Spec is designed to operate with a resolving power of 512 over the 500-1000 µm (300-600 GHz) wavelength range, a band of interest for several spectroscopic applications in astrophysics and the study of the early (z > 8) Universe. High-altitude balloon missions would provide the first testbed to demonstrate the µ-Spec technology in a space-like environment and would represent an economically viable venue for multiple observation campaigns.A brief overview of each instrument subsystem will be provided. Emphasis will be given to the design of the spectrometer’s two-dimensional diffractive region, through which the light of different wavelengths is focused on the kinetic inductance detectors along the focal plane. An optical design optimized for balloon missions through an optimization process that satisfies specific requirements on spectrometer’s size, operating spectral range and optical performance is presented in terms of geometric layout, spectral purity and efficiency.

Discrete event performance prediction of speculatively parallel temperature-accelerated dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zamora, Richard James; Voter, Arthur F.; Perez, Danny

Due to its unrivaled ability to predict the dynamical evolution of interacting atoms, molecular dynamics (MD) is a widely used computational method in theoretical chemistry, physics, biology, and engineering. Despite its success, MD is only capable of modeling time scales within several orders of magnitude of thermal vibrations, leaving out many important phenomena that occur at slower rates. The Temperature Accelerated Dynamics (TAD) method overcomes this limitation by thermally accelerating the state-to-state evolution captured by MD. Due to the algorithmically complex nature of the serial TAD procedure, implementations have yet to improve performance by parallelizing the concurrent exploration of multiplemore » states. Here we utilize a discrete event-based application simulator to introduce and explore a new Speculatively Parallel TAD (SpecTAD) method. We investigate the SpecTAD algorithm, without a full-scale implementation, by constructing an application simulator proxy (SpecTADSim). Finally, following this method, we discover that a nontrivial relationship exists between the optimal SpecTAD parameter set and the number of CPU cores available at run-time. Furthermore, we find that a majority of the available SpecTAD boost can be achieved within an existing TAD application using relatively simple algorithm modifications.« less

Discrete event performance prediction of speculatively parallel temperature-accelerated dynamics

DOE PAGES

Zamora, Richard James; Voter, Arthur F.; Perez, Danny; ...

2016-12-01

Due to its unrivaled ability to predict the dynamical evolution of interacting atoms, molecular dynamics (MD) is a widely used computational method in theoretical chemistry, physics, biology, and engineering. Despite its success, MD is only capable of modeling time scales within several orders of magnitude of thermal vibrations, leaving out many important phenomena that occur at slower rates. The Temperature Accelerated Dynamics (TAD) method overcomes this limitation by thermally accelerating the state-to-state evolution captured by MD. Due to the algorithmically complex nature of the serial TAD procedure, implementations have yet to improve performance by parallelizing the concurrent exploration of multiplemore » states. Here we utilize a discrete event-based application simulator to introduce and explore a new Speculatively Parallel TAD (SpecTAD) method. We investigate the SpecTAD algorithm, without a full-scale implementation, by constructing an application simulator proxy (SpecTADSim). Finally, following this method, we discover that a nontrivial relationship exists between the optimal SpecTAD parameter set and the number of CPU cores available at run-time. Furthermore, we find that a majority of the available SpecTAD boost can be achieved within an existing TAD application using relatively simple algorithm modifications.« less

Argonne's SpEC Module

ScienceCinema

Harper, Jason

2018-03-02

Jason Harper, an electrical engineer in Argonne National Laboratory's EV-Smart Grid Interoperability Center, discusses his SpEC Module invention that will enable fast charging of electric vehicles in under 15 minutes. The module has been licensed to BTCPower.

A Molecularly Imprinted Polymer (MIP)-Coated Microbeam MEMS Sensor for Chemical Detection

DTIC Science & Technology

2015-09-01

ARL-RP-0536 ● SEP 2015 US Army Research Laboratory A Molecularly Imprinted Polymer (MIP)- Coated Microbeam MEMS Sensor for...ARL-RP-0536 ● SEP 2015 US Army Research Laboratory A Molecularly Imprinted Polymer (MIP)- Coated Microbeam MEMS Sensor for Chemical...TITLE AND SUBTITLE A Molecularly Imprinted Polymer (MIP)-Coated Microbeam MEMS Sensor for Chemical Detection 5a. CONTRACT NUMBER 5b. GRANT NUMBER

Proceedings of the Second Workshop on Numerical Analysis of Human and Surrogate Response to Accelerative Loading

DTIC Science & Technology

2018-02-01

Dissection  2 primary experimental loading cases Tissue-Level Characterization Quasi -Static Bending (Hueur et al., 2006) High-Rate Combined...Yang Hybrid III Crash-Dummy Lower Ext. under High Speed Vertical Loading: A Combined Experimental and Computational Study Wayne State 14:05...25 Tusit Weerasooriya Mechanical Response of Human and Animal Bones: Overview of ARL Experimental Research ARL 11:50 Wayne Chen

Bragg Reflector-Induced Increased Nonradiative Lifetime in Gallium Arsenide (GaAs)/Aluminum Gallium Arsenide (AlGaAs) Double Heterostructures

DTIC Science & Technology

2015-09-01

ARL-TR-7473 ● SEP 2015 US Army Research Laboratory Bragg Reflector-Induced Increased Nonradiative Lifetime in Gallium Arsenide...return it to the originator. ARL-TR-7473 ● SEP 2015 US Army Research Laboratory Bragg Reflector-Induced Increased Nonradiative ...3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Bragg Reflector-Induced Increased Nonradiative Lifetime in Gallium Arsenide (GaAs)/Aluminum

Generating Variable Wind Profiles and Modeling Their Effects on Small-Arms Trajectories

DTIC Science & Technology

2016-04-01

ARL-TR-7642 ● APR 2016 US Army Research Laboratory Generating Variable Wind Profiles and Modeling Their Effects on Small-Arms... Wind Profiles and Modeling Their Effects on Small-Arms Trajectories by Timothy A Fargus Weapons and Materials Research Directorate, ARL...Generating Variable Wind Profiles and Modeling Their Effects on Small-Arms Trajectories 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM

Influence of Thermal Annealing and a Glass Coating on the Strength of Soda-Lime-Silicate Glass

DTIC Science & Technology

2017-11-01

ARL-TN-0858 ● NOV 2017 US Army Research Laboratory Influence of Thermal Annealing and a Glass Coating on the Strength of Soda...NOV 2017 US Army Research Laboratory Influence of Thermal Annealing and a Glass Coating on the Strength of Soda-Lime-Silicate Glass... Research Directorate, ARL Approved for public release; distribution is unlimited. ii REPORT DOCUMENTATION PAGE Form Approved OMB

Crystal Thermoelasticity at Extreme Loading Rates and Pressures: Analysis of Higher-Order Energy Potentials

DTIC Science & Technology

2015-07-01

ARL-RP-0526 ● JULY 2015 US Army Research Laboratory Crystal Thermoelasticity at Extreme Loading Rates and Pressures : Analysis of...ARL-RP-0526 ● JULY 2015 US Army Research Laboratory Crystal Thermoelasticity at Extreme Loading Rates and Pressures : Analysis of...2015 4. TITLE AND SUBTITLE Crystal Thermoelasticity at Extreme Loading Rates and Pressures : Analysis of Higher-Order Energy Potentials 5a. CONTRACT

100 Years of Army Artillery Meteorology: A Brief Summary

DTIC Science & Technology

2018-02-01

ARL-TN-0871 ● Feb 2018 US Army Research Laboratory 100 Years of Army Artillery Meteorology: A Brief Summary by J L Cogan...to the originator. ARL-TN-0871● Feb 2018 US Army Research Laboratory 100 Years of Army Artillery Meteorology: A Brief Summary...WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) US Army Research Laboratory ATTN: RDRL-CIE Aberdeen Proving Ground, MD

A Discrete Scatterer Technique for Evaluating Electromagnetic Scattering from Trees

DTIC Science & Technology

2016-09-01

ARL-TR-7799 ● SEP 2016 US Army Research Laboratory A Discrete Scatterer Technique for Evaluating Electromagnetic Scattering from...longer needed. Do not return it to the originator. ARL-TR-7799 ● SEP 2016 US Army Research Laboratory A Discrete Scatterer Technique...DD-MM-YYYY) September 2016 2. REPORT TYPE Technical Report 3. DATES COVERED (From - To) 2015–2016 4. TITLE AND SUBTITLE A Discrete Scatterer

Les Representations Sociales de la Ville Chez les Ecoliers de Deux Villes Europeennes, d'Arles et de Sparte: Une Approche Comparative.

ERIC Educational Resources Information Center

Zafeirakou, Aegli

1998-01-01

In an exchange program, 11- and 12-year olds from Arles (France) (n=25) and Sparta (Greece) (n=27) visited each other's cities and explored the culture and history. This study explores the ways they conceptualized the cultural patrimony of both cities through student drawings. The exchange created opportunities for dialog about European culture.…

Adding Liquid Payloads Effects to the 6-DOF Trajectory of Spinning Projectiles

DTIC Science & Technology

2010-03-01

Adding Liquid Payloads Effects to the 6-DOF Trajectory of Spinning Projectiles by Gene R. Cooper ARL-TR-5118 March 2010...Liquid Payloads Effects to the 6-DOF Trajectory of Spinning Projectiles Gene R. Cooper Weapons and Materials Research Directorate, ARL...September 2007 4. TITLE AND SUBTITLE Adding Liquid Payloads Effects to the 6-DOF Trajectory of Spinning Projectiles 5a. CONTRACT NUMBER 5b. GRANT

Stimulated Brillouin Scattering (SBS) Suppression and Long Delivery Fibers at the Multikilowatt Level with Chirped Seed Lasers

DTIC Science & Technology

2017-03-16

stimulated Brillouin scattering [SBS]) due to the large intensity times length product. Efforts to raise the power threshold include 1) reducing the...ARL-TR-7979 ● MAR 2017 US Army Research Laboratory Stimulated Brillouin Scattering (SBS) Suppression and Long Delivery Fibers at...return it to the originator. ARL-TR-7979 ● MAR 2017 US Army Research Laboratory Stimulated Brillouin Scattering (SBS

Using Cognitive Control in Software Defined Networking for Port Scan Detection

DTIC Science & Technology

2017-07-01

ARL-TR-8059 ● July 2017 US Army Research Laboratory Using Cognitive Control in Software-Defined Networking for Port Scan...Cognitive Control in Software-Defined Networking for Port Scan Detection by Vinod K Mishra Computational and Information Sciences Directorate, ARL...currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) July 2017 2. REPORT TYPE

Cobalt-Base Alloy Gun Barrel Study

DTIC Science & Technology

2014-07-01

Cobalt-Base Alloy Gun Barrel Study by William S. de Rosset and Jonathan S. Montgomery ARL-RP-0491 July 2014 A reprint...21005-5069 ARL-RP-0491 July 2014 Cobalt-Base Alloy Gun Barrel Study William S. de Rosset and Jonathan S. Montgomery Weapons and Materials... Gun Barrel Study 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) William S. de Rosset and Jonathan S. Montgomery

Continuous System-Level Scale for Comparing Laser Gain Media

DTIC Science & Technology

2008-12-01

thickness in Yb3+-doped microchip lasers . J. Opt. Soc. Am. B October 2003, 20, 2061–2067. 29. Liu, Q.; Gong, M.; Lu, F.; Gong, W.; Li, C. 520-W...Continuous “System-Level” Scale for Comparing Laser Gain Media by Jeffrey O. White ARL-TR-4682 December 2008...System-Level” Scale for Comparing Laser Gain Media Jeffrey O. White Sensors and Electron Devices Directorate, ARL

US Army Research Laboratory Visualization Framework Design Document

DTIC Science & Technology

2016-01-01

This section highlights each module in the ARL-VF and subsequent sections provide details on how each module interacts . Fig. 2 ARL-VF with the...ConfigAgent MultiTouch VizDatabase VizController TUIO VizDatabase User VizDaemon VizDaemon VizDaemon VizDaemon VizDaemon TestPoint...received by the destination. The sequence diagram in Fig. 4 shows this interaction . Approved for public release; distribution unlimited. 13 Fig. 4

Bio-Based Polyurethane Containing Isosorbide for Use in Composites and Coatings

DTIC Science & Technology

2015-04-01

ARL-TR-7259 ● APR 2015 US Army Research Laboratory Bio-Based Polyurethane Containing Isosorbide for Use in Composites and...copyright notation hereon. ARL-TR-7259 ● APR 2015 US Army Research Laboratory Bio-Based Polyurethane Containing Isosorbide for Use...4. TITLE AND SUBTITLE Bio-Based Polyurethane Containing Isosorbide for Use in Composites and Coatings 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

Education determines a nation's health, but what determines educational outcomes? A cross-national comparative analysis.

PubMed

Siddiqi, Arjumand; Kawachi, Ichiro; Berkman, Lisa; Hertzman, Clyde; Subramanian, S V

2012-02-01

This study is premised on the notion that public health policy should address not only health itself, but also primary determinants of health. We examined the effect of national policies on educational outcomes, in particular, on adolescent reading literacy (ARL). We compared the effect of traditional policy indicators--national income and educational spending--with income inequality, a measure of redistributive policies. We used Organization for Economic Cooperation and Development (OECD) data that provide a rare opportunity to test policy effects after accounting for competing individual-, school-, and country-level explanations. Our sample consisted of 119,814 students, 5126 schools, and 24 countries. Multilevel/Hierarchical regression findings were striking: GDP had a significant, but negligible effect on ARL scores (β=0.002, SE=0.0008), while educational spending had no significant effect. By contrast, income inequality exhibited a larger inverse association (β=-1.15, SE=0.57). Among the wealthy nations in OECD, additional economic prosperity and educational spending is trumped by distribution of income for its effect on ARL. Our study yielded a striking result about education, a major determinant of health. Not only is income inequality a significant determinant of ARL scores, but direct spending on education and overall national economic prosperity are not.

Anti-ship missile tracking with a chirped amplitude modulation ladar

NASA Astrophysics Data System (ADS)

Redman, Brian C.; Stann, Barry L.; Ruff, William C.; Giza, Mark M.; Aliberti, Keith; Lawler, William B.

2004-09-01

Shipboard infrared search and track (IRST) systems can detect sea-skimming anti-ship missiles at long ranges. Since IRST systems cannot measure range and velocity, they have difficulty distinguishing missiles from slowly moving false targets and clutter. ARL is developing a ladar based on its patented chirped amplitude modulation (AM) technique to provide unambiguous range and velocity measurements of targets handed over to it by the IRST. Using the ladar's range and velocity data, false alarms and clutter objects will be distinguished from valid targets. If the target is valid, it's angular location, range, and velocity, will be used to update the target track until remediation has been effected. By using an array receiver, ARL's ladar can also provide 3D imagery of potential threats in support of force protection. The ladar development program will be accomplished in two phases. In Phase I, currently in progress, ARL is designing and building a breadboard ladar test system for proof-of-principle static platform field tests. In Phase II, ARL will build a brassboard ladar test system that will meet operational goals in shipboard testing against realistic targets. The principles of operation for the chirped AM ladar for range and velocity measurements, the ladar performance model, and the top-level design for the Phase I breadboard are presented in this paper.

Temperature Sensing for Oil, Gas, and Structural Analysis

NASA Technical Reports Server (NTRS)

2006-01-01

In 1996, Systems and Processes Engineering Corporation (SPEC), of Austin, Texas, undertook a NASA Small Business Innovation Research (SBIR) contract with Langley Research Center to develop a compact and lightweight digital thermal sensing (DTS) system for monitoring the cryogenic tanks on the X-33 prototype aircraft. That technology, along with a processor developed by SPEC for Goddard Space Flight Center, was space-qualified and integrated into several NASA missions. SPEC formed an ancillary organization, SensorTran, Inc., to continue work developing the DTS technology for a variety of commercial and industrial applications.

Rapid sequential determination of Pu, 90Sr and 241Am nuclides in environmental samples using an anion exchange and Sr-Spec resins.

PubMed

Lee, M H; Ahn, H J; Park, J H; Park, Y J; Song, K

2011-02-01

This paper presents a quantitative and rapid method of sequential separation of Pu, (90)Sr and (241)Am nuclides in environmental soil samples with an anion exchange resin and Sr Spec resin. After the sample solution was passed through an anion exchange column connected to a Sr Spec column, Pu isotopes were purified from the anion exchange column. Strontium-90 was separated from other interfering elements by the Sr Spec column. Americium-241 was purified from lanthanides by the anion exchange resin after oxalate co-precipitation. Measurement of Pu and Am isotopes was carried out using an α-spectrometer. Strontium-90 was measured by a low-level liquid scintillation counter. The radiochemical procedure of Pu, (90)Sr and (241)Am nuclides investigated in this study validated by application to IAEA reference materials and environmental soil samples. Copyright © 2010 Elsevier Ltd. All rights reserved.

Remotely Controlled Mixers for Light Microscopy Module (LMM) Colloid Samples

NASA Technical Reports Server (NTRS)

Kurk, Michael A. (Andy)

2015-01-01

Developed by NASA Glenn Research Center, the LMM aboard the International Space Station (ISS) is enabling multiple biomedical science experiments. Techshot, Inc., has developed a series of colloid specialty cell systems (C-SPECS) for use in the colloid science experiment module on the LMM. These low-volume mixing devices will enable uniform particle density and remotely controlled repetition of LMM colloid experiments. By automating the experiment process, C-SPECS allow colloid samples to be processed more quickly. In addition, C-SPECS will minimize the time the crew will need to spend on colloid experiments as well as eliminate the need for multiple and costly colloid samples, which are expended after a single examination. This high-throughput capability will lead to more efficient and productive use of the LMM. As commercial launch vehicles begin routine visits to the ISS, C-SPECS could become a significant means to process larger quantities of high-value materials for commercial customers.

Validation of a commercial 1,2-o-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin) ester lipase assay for diagnosis of canine pancreatitis.

PubMed

Goodband, Emily L; Serrano, Gonçalo; Constantino-Casas, Fernando; Archer, Joy; Watson, Penny J; Williams, Tim L

2018-01-01

The objectives of this study were fourfold: technical validation of a commercial canine 1,2-o-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin) ester (DGGR) lipase assay, to calculate a reference interval for DGGR lipase by the indirect a posteriori method, to establish biological validity of the assay, and to assess agreement between DGGR lipase and specific canine pancreatic lipase (Spec cPL) assays. Dogs with histologically confirmed acute pancreatitis (n=3), chronic pancreatitis (n=8) and normal pancreatic tissue (n=7) with stored (-80°C) serum samples were identified. Relevant controls were selected. Precision, reproducibility and linearity of DGGR lipase, and the effect of sample haemolysis and freezing, were assessed. Sensitivity and specificity of DGGR lipase and Spec cPL were determined. Agreement between these two parameters was calculated using Cohen's kappa coefficient (κ). The DGGR lipase assay demonstrated excellent precision, reproducibility and linearity. Sample haemolysis and storage at -80°C for 12 months did not influence the assay. DGGR lipase (>245IU/l) and Spec cPL (>400µg/l) both showed poor sensitivity but excellent specificity for acute pancreatitis, and poor to moderate sensitivity but excellent specificity for chronic pancreatitis. Substantial agreement (κ=0.679) was found between DGGR lipase and Spec cPL. The validated DGGR lipase assay had similar sensitivity and specificity for the diagnosis of acute and chronic pancreatitis to Spec cPL. DGGR lipase is a reliable alternative to Spec cPL for the diagnosis of pancreatitis.

Eclipse Science Results from the Airborne Infrared Spectrometer (AIR-Spec)

NASA Astrophysics Data System (ADS)

Samra, J.; Cheimets, P.; DeLuca, E.; Golub, L.; Judge, P. G.; Lussier, L.; Madsen, C. A.; Marquez, V.; Tomczyk, S.; Vira, A.

2017-12-01

We present the first science results from the commissioning flight of the Airborne Infrared Spectrometer (AIR-Spec), an innovative solar spectrometer that will observe the 2017 solar eclipse from the NSF/NCAR High-Performance Instrumented Airborne Platform for Environmental Research (HIAPER). During the eclipse, AIR-Spec will image five magnetically sensitive coronal emission lines between 1.4 and 4 microns to determine whether they may be useful probes of coronal magnetism. The instrument will measure emission line intensity, FWHM, and Doppler shift from an altitude of over 14 km, above local weather and most of the absorbing water vapor. Instrumentation includes an image stabilization system, feed telescope, grating spectrometer, infrared camera, and visible slit-jaw imager. Results from the 2017 eclipse are presented in the context of the mission's science goals. AIR-Spec will identify line strengths as a function of position in the solar corona and search for the high frequency waves that are candidates for heating and acceleration of the solar wind. The instrument will also identify large scale flows in the corona, particularly in polar coronal holes. Three of the five lines are expected to be strong in coronal hole plasmas because they are excited in part by scattered photospheric light. Line profile analysis will probe the origins of the fast and slow solar wind. Finally, the AIR-Spec measurements will complement ground based eclipse observations to provide detailed plasma diagnostics throughout the corona. AIR-Spec will measure infrared emission of ions observed in the visible from the ground, giving insight into plasma heating and acceleration at radial distances inaccessible to existing or planned spectrometers.

MultiSpec—a tool for multispectral hyperspectral image data analysis

NASA Astrophysics Data System (ADS)

Biehl, Larry; Landgrebe, David

2002-12-01

MultiSpec is a multispectral image data analysis software application. It is intended to provide a fast, easy-to-use means for analysis of multispectral image data, such as that from the Landsat, SPOT, MODIS or IKONOS series of Earth observational satellites, hyperspectral data such as that from the Airborne Visible-Infrared Imaging Spectrometer (AVIRIS) and EO-1 Hyperion satellite system or the data that will be produced by the next generation of Earth observational sensors. The primary purpose for the system was to make new, otherwise complex analysis tools available to the general Earth science community. It has also found use in displaying and analyzing many other types of non-space related digital imagery, such as medical image data and in K-12 and university level educational activities. MultiSpec has been implemented for both the Apple Macintosh ® and Microsoft Windows ® operating systems (OS). The effort was first begun on the Macintosh OS in 1988. The GLOBE ( http://www.globe.gov) program supported the development of a subset of MultiSpec for the Windows OS in 1995. Since then most (but not all) of the features in the Macintosh OS version have been ported to the Windows OS version. Although copyrighted, MultiSpec with its documentation is distributed without charge. The Macintosh and Windows versions and documentation on its use are available from the World Wide Web at URL: http://dynamo.ecn.purdue.edu/˜biehl/MultiSpec/ MultiSpec is copyrighted (1991-2001) by Purdue Research Foundation, West Lafayette, Indiana 47907.

Making Optic Flow Robust to Dynamic Lighting Conditions for Real-Time Operation

DTIC Science & Technology

2016-03-17

ARL-TR-7629 ● MAR 2016 US Army Research Laboratory Making Optic Flow Robust to Dynamic Lighting Conditions for Real-Time...ARL-TR-7629 ● MAR 2016 US Army Research Laboratory Making Optic Flow Robust to Dynamic Lighting Conditions for Real-Time Operation...SUBTITLE Making Optic Flow Robust to Dynamic Lighting Conditions for Real-Time Operation 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

Usability Study and Heuristic Evaluation of the Applied Robotics for Installations and Base Operations (ARIBO) Driverless Vehicle Reservation Application ARIBO Mobile

DTIC Science & Technology

2017-03-01

ARL-TN-0814 ● MAR 2017 US Army Research Laboratory Usability Study and Heuristic Evaluation of the Applied Robotics for...ARL-TN-0814 ● MAR 2017 US Army Research Laboratory Usability Study and Heuristic Evaluation of the Applied Robotics for...Heuristic Evaluation of the Applied Robotics for Installations and Base Operations (ARIBO) Driverless Vehicle Reservation Application ARIBO Mobile 5a

Pre- and Post-Processing Tools to Create and Characterize Particle-Based Composite Model Structures

DTIC Science & Technology

2017-11-01

ARL-TR-8213 ● NOV 2017 US Army Research Laboratory Pre- and Post -Processing Tools to Create and Characterize Particle-Based...ARL-TR-8213 ● NOV 2017 US Army Research Laboratory Pre- and Post -Processing Tools to Create and Characterize Particle-Based Composite...AND SUBTITLE Pre- and Post -Processing Tools to Create and Characterize Particle-Based Composite Model Structures 5a. CONTRACT NUMBER 5b. GRANT

Using Ferromagnetic Material to Extend and Shield the Magnetic Field of a Coil

DTIC Science & Technology

2017-06-14

ARL-MR-0954 ● Jun 2017 US Army Research Laboratory Using Ferromagnetic Material to Extend and Shield the Magnetic Field of a...to Extend and Shield the Magnetic Field of a Coil by W Casey Uhlig Weapons and Materials Research Directorate, ARL...Using Ferromagnetic Material to Extend and Shield the Magnetic Field of a Coil 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER

A Rod Ricochet Model

DTIC Science & Technology

2004-08-01

PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER AH80 5e. TASK NUMBER 6. AUTHOR( S ) Steven B. Segletes 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION...NAME( S ) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN: AMSRD-ARL-WM-TD Aberdeen Proving Ground, MD 21005-5066 8. PERFORMING ORGANIZATION...REPORT NUMBER ARL-TR-3257 10. SPONSOR/MONITOR’S ACRONYM( S ) 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 11. SPONSOR/MONITOR’S

Constraints on the Grueneisen Theory

DTIC Science & Technology

2007-02-01

Constraints on the Grüneisen Theory 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER AH80 5e. TASK NUMBER 6. AUTHOR( S ) Steven B. Segletes 5f...WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN: AMSRD-ARL-WM-TD Aberdeen Proving Ground...MD 21005-5069 8. PERFORMING ORGANIZATION REPORT NUMBER ARL-TR-4041 10. SPONSOR/MONITOR’S ACRONYM( S ) 9. SPONSORING/MONITORING AGENCY NAME

High Fidelity Simulation of Atomization in Diesel Engine Sprays

DTIC Science & Technology

2015-09-01

ARL-RP-0555 ● SEP 2015 US Army Research Laboratory High Fidelity Simulation of Atomization in Diesel Engine Sprays by L Bravo...ARL-RP-0555 ● SEP 2015 US Army Research Laboratory High Fidelity Simulation of Atomization in Diesel Engine Sprays by L...Simulation of Atomization in Diesel Engine Sprays 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) L Bravo, CB Ivey, D

Urban Terrain Building Types: Second Edition Public Releasable Version

DTIC Science & Technology

2012-11-01

in this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents...longer needed. Do not return it to the originator. Army Research Laboratory Aberdeen Proving Ground, MD 21005-5067 ARL-TR-4395a November 2012...ADDRESS(ES) U.S. Army Research Laboratory ATTN: AMSRD-ARL-SL-BA Aberdeen Proving Ground, MD 21005-5067 10. SPONSOR/MONITOR’S ACRONYM(S) 11

Computational Fluid Dynamic (CFD) Study of an Articulating Turbine Blade Cascade

DTIC Science & Technology

2016-11-01

turbine blades to have fluid run through them during use1—a feature which many newer engines include. A cutaway view of a typical rotorcraft engine...ARL-TR-7871 ● NOV 2016 US Army Research Laboratory Computational Fluid Dynamic (CFD) Study of an Articulating Turbine Blade ...ARL-TR-7871 ● NOV 2016 US Army Research Laboratory Computational Fluid Dynamic (CFD) Study of an Articulating Turbine Blade Cascade by Luis

2017 ARL Summer Student Program. Volume 1: Symposium Presentations

DTIC Science & Technology

2017-12-01

The findings in this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents...and publicize exceptional achievements made by students and their mentors in support of Army science. All undergraduate and graduate interns are ...finalists are published in Volume I of the proceedings (“Symposium Presentations”; ARL-SR-0387), while abstracts are collected in Volume II (“Compendium of

Excluding Noise from Short Krylov Subspace Approximations to the Truncated Singular Value Decomposition (SVD)

DTIC Science & Technology

2017-09-27

ARL-TR-8161•SEP 2017 US Army Research Laboratory Excluding Noise from Short Krylov Subspace Approximations to the Truncated Singular Value...originator. ARL-TR-8161•SEP 2017 US Army Research Laboratory Excluding Noise from Short Krylov Subspace Approximations to the Truncated Singular Value...unlimited. October 2015–January 2016 US Army Research Laboratory ATTN: RDRL-CIH-C Aberdeen Proving Ground, MD 21005-5066 primary author’s email

Measuring and Inferring the State of the User via the Microsoft Kinect with Application to Cyber Security Research

DTIC Science & Technology

2018-01-16

ARL-TN-0864 ● JAN 2018 US Army Research Laboratory Measuring and Inferring the State of the User via the Microsoft Kinect with...Application to Cyber Security Research by Christopher J Garneau Approved for public release; distribution is unlimited...this report when it is no longer needed. Do not return it to the originator. ARL-TN-0864● JAN 2018 US Army Research Laboratory

Fabrication of High Strength Lightweight Metals for Armor and Structural Applications: Large Scale Equal Channel Angular Extrusion Processing of Aluminum 5083 Alloy

DTIC Science & Technology

2017-06-01

ARL-TR-8047 ● JUNE 2017 US Army Research Laboratory Fabrication of High -Strength Lightweight Metals for Armor and Structural...to the originator. ARL-TR-8047 ● JUNE 2017 US Army Research Laboratory Fabrication of High -Strength Lightweight Metals for...Fabrication of High -Strength Lightweight Metals for Armor and Structural Applications: Large-Scale Equal Channel Angular Extrusion Processing of

The Human Dimension of Networks

DTIC Science & Technology

2008-06-01

Networking Organizational Issues Authors: Bruce J. West Ph.D. Army Research Office Elizabeth K. Bowman Ph.D. Army Research Laboratory – Human...Contact: Elizabeth K.Bowman AMSRD-ARL-HR Bulding 459, Aberdeen Proving Ground, MD 21005 410-278-5924 EBowman@arl.army.mil 1 Report Documentation Page...L.E. Brus , Nature 383, 802 (1996); M. Kuno, D.P. Fromim, s.R. Hohmson, A. Gallagher and D.J. Nesbitt, Phys. Rev. B 67, 125304 (2003); K.R. Shimizu

US Army Research Laboratory and University of Notre Dame Distributed Sensing: Software Overview

DTIC Science & Technology

2017-09-01

ARL-TN-0847 ● Sep 2017 US Army Research Laboratory US Army Research Laboratory and University of Notre Dame Distributed Sensing...Destroy this report when it is no longer needed. Do not return it to the originator. ARL-TN-0847 ● Sep 2017 US Army Research Laboratory...US Army Research Laboratory and University of Notre Dame Distributed Sensing: Software Overview by Neal Tesny Sensors and Electron Devices

Development of an Anatomically Accurate Finite Element Human Ocular Globe Model for Blast-Related Fluid-Structure Interaction Studies

DTIC Science & Technology

2017-02-01

ARL-TR-7945 ● FEB 2017 US Army Research Laboratory Development of an Anatomically Accurate Finite Element Human Ocular Globe...ARL-TR-7945 ● FEB 2017 US Army Research Laboratory Development of an Anatomically Accurate Finite Element Human Ocular Globe Model... Finite Element Human Ocular Globe Model for Blast-Related Fluid-Structure Interaction Studies 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM

Meteorological Error Budget Using Open Source Data

DTIC Science & Technology

2016-09-01

ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using Open- Source Data by J Cogan, J Smith, P...needed. Do not return it to the originator. ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using...Error Budget Using Open-Source Data 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) J Cogan, J Smith, P Haines

Dynamic Multiaxial Response of a Hot-Pressed Aluminum Nitride

DTIC Science & Technology

2012-01-05

Hutchinson, Adv. Appl . Mech. 29 (1992). [34] H. Ming-Yuan, J.W. Hutchinson, Int. J. Solids Struct. 25 (1989) 1053. [35] J. Salem , L. Ghosn, Int. J...Dynamic Multiaxial Response of a Hot- Pressed Aluminum Nitride by Guangli Hu, C. Q. Chen, K. T. Ramesh, and J. W. McCauley ARL-RP-0487...Laboratory Aberdeen Proving Ground, MD 21005-5066 ARL-RP-0487 June 2014 Dynamic Multiaxial Response of a Hot- Pressed Aluminum Nitride

Hydrodynamic Test Facilities at ARL/PSU.

DTIC Science & Technology

1982-02-12

integral scale of 1.25 cm, by the addition of honey- comb in the settling section; and (4) the development of electro- optical measuring techniques. In...the NASA tunnel and its very high velocity, has been to study the process of cavitation damage [13]. Recent studies at ARL/PSU have confirmed the...at frequencies > 300 Hz. When used in con- junction with other sensors located in the test section, dual- channel signal processing can be used to

Quantifying Damage at Multiple Loading Rates to Kevlar KM2 Fibers Due to Weaving and Finishing

DTIC Science & Technology

2013-06-01

ARL-TR-6465 June 2013 Approved for public release; distribution is unlimited. NOTICES...ARL-TR-6465 June 2013 Quantifying Damage at Multiple Loading Rates to Kevlar KM2 Fibers Due to Weaving and Finishing Brett D. Sanborn...OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) June 2013 2. REPORT TYPE Final 3. DATES

Microstructural Effects on the Spall Properties of ECAE-Processed AZ31B Magnesium Alloy

DTIC Science & Technology

2016-10-01

ARL-RP-0580 ● OCT 2016 US Army Research Laboratory Microstructural Effects on the Spall Properties of ECAE-Processed AZ31B...not to be construed as an official Department of the Army position unless so designated by other authorized documents. Citation of manufacturer’s...return it to the originator. ARL-RP-0580 ● OCT 2016 US Army Research Laboratory Microstructural Effects on the Spall Properties

A Summary of Crew Workload and Situational Awareness Ratings for U.S. Army Aviation Aircraft

DTIC Science & Technology

2014-06-01

Engineering Directorate (ARL/HRED) assesses crewstation design for new and upgraded U.S. Army Aviation aircraft during simulations and operational...crewstation design for new and upgraded Army Aviation aircraft during simulations and operational testing. The assessments are conducted to identify...crewstation design . To date, more than 12,000 pilot workload ratings and 3000 pilot SA ratings have been collected by ARL/HRED for Army aircraft . This report

Modeling and Simulation of Ballistic Penetration of Ceramic-Polymer-Metal Layered Systems

DTIC Science & Technology

2016-01-01

ARL-RP-0562 ● JAN 2016 US Army Research Laboratory Modeling and Simulation of Ballistic Penetration of Ceramic-Polymer-Metal...manufacturer’s or trade names does not constitute an official endorsement or approval of the use thereof. Destroy this report when it is no longer needed...Do not return it to the originator. ARL-RP-0562 ● JAN 2016 US Army Research Laboratory Modeling and Simulation of Ballistic

Examining the Convergent and Discriminant Validity of Visual and Mental Workload Using Ocular Activity Variables

DTIC Science & Technology

2010-03-01

Laboratory ATTN: RDRL- HRM -DI Aberdeen Proving Ground, MD 21005-5425 8. PERFORMING ORGANIZATION REPORT NUMBER ARL-TR-5132 9. SPONSORING... Automobile drivers can successfully manage lateral movement and appropriate acceleration parameters, and listening to a radio does not appear to...JOHN J KINGMAN RD STE 0944 FT BELVOIR VA 22060-6218 1 ARL FIRES CENTER OF EXCELLENCE FIELD ELEMENT ATTN RDRL HRM AF C HERNANDEZ

Research@ARL: Materials Modeling at Multiple Scales. Volume 3, Issue 2

DTIC Science & Technology

2014-07-01

possessing high ionic conductivity , low viscosity, and good thermal and electrochemical stability and, importantly, being compatible with electrodes. As... thermal and electrical properties. ARL conducts extensive research in graphene and other 2D materials such as BN, ZnO, and hybrid graphene-polyethylene...contribution at temperatures below 393 K. Thus, below 393 K, Li2EDC essentially acts as a single ion conductor . The isotropic ionic conductivity from MD

An Automated Energy Detection Algorithm Based on Morphological Filter Processing with a Modified Watershed Transform

DTIC Science & Technology

2018-01-01

collected data. These statistical techniques are under the area of descriptive statistics, which is a methodology to condense the data in quantitative ...ARL-TR-8270 ● JAN 2018 US Army Research Laboratory An Automated Energy Detection Algorithm Based on Morphological Filter...report when it is no longer needed. Do not return it to the originator. ARL-TR-8270 ● JAN 2017 US Army Research Laboratory An

Thermoelectric Properties of Cobalt Triantimonide (CoSb3) Prepared by an Electrochemical Technique

DTIC Science & Technology

2010-04-01

of the Co0.95Pd0.05Te0.05Sb2.95 material. Y. Lan et al . (5) suggested that the 9 mean free path for electrons in doped silicon (Si)-germanium...Sakamoto ARL-TR-5141 April 2010 Approved for public release; distribution unlimited...Adelphi, MD 20783-1197 ARL-TR-5141 April 2010 Thermoelectric Properties of Cobalt Triantimonide (CoSb3) Prepared by an Electrochemical

Demonstration/Validation of Low Volatile Organic Compound (VOC) Chemical Agent Resistant Coating (CARC)

DTIC Science & Technology

2003-11-25

alkyd resin enamel was 14 Figure 1 -- Test Panels Before Application of WD CARC at MCB Figure 2 -- Test Panels with WD CARC Applied at MCB...WD) Chemical Agent Resistant Coating (CARC) patented (#5,691,410) by the Army Research Laboratory (ARL) has undergone technology Demonstration...Resistant Coating (CARC) patented (#5,691,410) by the Army Research Laboratory (ARL) has undergone technology Demonstration/Validation (Dem/Val) testing

SpecTracer: A Python-Based Interactive Solution for Echelle Spectra Reduction

NASA Astrophysics Data System (ADS)

Romero Matamala, Oscar Fernando; Petit, Véronique; Caballero-Nieves, Saida Maria

2018-01-01

SpecTracer is a newly developed interactive solution to reduce cross dispersed echelle spectra. The use of widgets saves the user the steep learning curves of currently available reduction software. SpecTracer uses well established image processing techniques based on IRAF to succesfully extract the stellar spectra. Comparisons with other reduction software, like IRAF, show comparable results, with the added advantages of ease of use, platform independence and portability. This tool can obtain meaningful scientific data and serve also as a training tool, especially for undergraduates doing research, in the procedure for spectroscopic analysis.

A huge diversity of metopids (Ciliophora, Armophorea) in soil from the Murray River floodplain, Australia. I. Description of five new species and redescription of Metopus setosus Kahl, 1927.

PubMed

Vďačný, Peter; Foissner, Wilhelm

2017-04-01

Six metopid ciliates from soil of the Murray River floodplain in Australia were studied using live observation, various silver impregnation methods, scanning electron microscopy, and multivariate statistics. One of the species is affiliated with M. setosus while the others represent new taxa. Metopus filum nov. spec. is distinguished from most congeners by the slender body, the absence of cortical granules, and the low number of ciliary rows and adoral polykinetids. Metopus palaeformides nov. spec. most resembles Heterometopus palaeformis (Kahl, 1927) Foissner, 2016b but they can be distinguished by body size, the number of adoral polykinetids, and the oral area pattern. Metopus murrayensis nov. spec. is outstanding in having a globular macronucleus surrounded by innumerable refractive granules and a conspicuously thick preoral dome. Metopus rex nov. spec. and M. magnus nov. spec. are easily distinguished from most congeners by their large body size and the shape of the macronucleus. Moreover, M. rex displays up to 30μm long endosymbiotic bacteria while the micronucleus of M. magnus is uniquely situated in a small macronuclear concavity. Multivariate statistics corroborates the distinctness of these six metopid populations. Copyright © 2016 Elsevier GmbH. All rights reserved.

Second-Generation Design of Micro-Spec: A Medium-Resolution, Submillimeter-Wavelength Spectrometer-on-a-Chip

NASA Astrophysics Data System (ADS)

Cataldo, G.; Barrentine, E. M.; Bulcha, B. T.; Ehsan, N.; Hess, L. A.; Noroozian, O.; Stevenson, T. R.; U-Yen, K.; Wollack, E. J.; Moseley, S. H.

2018-04-01

Micro-Spec (µ-Spec) is a direct-detection spectrometer which integrates all the components of a diffraction-grating spectrometer onto a ˜ 10-cm^2 chip through the use of superconducting microstrip transmission lines on a single-crystal silicon substrate. A second-generation µ-Spec is being designed to operate with a spectral resolution of 512 in the submillimeter (500-1000 µm, 300-600 GHz) wavelength range, a band of interest for several spectroscopic applications in astrophysics. High-altitude balloon missions would provide the first test bed to demonstrate the µ-Spec technology in a space-like environment and would be an economically viable venue for multiple observation campaigns. This work reports on the current status of the instrument design and will provide a brief overview of each instrument subsystem. Particular emphasis will be given to the design of the spectrometer's two-dimensional diffractive region, through which the light of different wavelengths is focused on the detectors along the focal plane. An optimization process is employed to generate geometrical configurations of the diffractive region that satisfy specific requirements on spectrometer size, operating spectral range, and performance. An optical design optimized for balloon missions will be presented in terms of geometric layout, spectral purity, and efficiency.

SPECS: the kilometer-baseline far-IR interferometer in NASA's space science roadmap

NASA Astrophysics Data System (ADS)

Leisawitz, David T.; Abel, Tom; Allen, Ronald J.; Benford, Dominic J.; Blain, Andrew; Bombardelli, Claudio; Calzetti, Daniela; DiPirro, Michael J.; Ehrenfreund, Pascale; Evans, Neal J., II; Fischer, Jacqueline; Harwit, Martin; Hyde, Tristram T.; Kuchner, Marc J.; Leitner, Jesse A.; Lorenzini, Enrico C.; Mather, John C.; Menten, Karl M.; Moseley, Samuel H., Jr.; Mundy, Lee G.; Nakagawa, Takao; Neufeld, David A.; Pearson, John C.; Rinehart, Stephen A.; Roman, Juan; Satyapal, Shobita; Silverberg, Robert F.; Stahl, H. Philip; Swain, Mark R.; Swanson, Theodore D.; Traub, Wesley A.; Wright, Edward L.; Yorke, Harold W.

2004-10-01

Ultimately, after the Single Aperture Far-IR (SAFIR) telescope, astrophysicists will need a far-IR observatory that provides angular resolution comparable to that of the Hubble Space Telescope. At such resolution galaxies at high redshift, protostars, and nascent planetary systems will be resolved, and theoretical models for galaxy, star, and planet formation and evolution can be subjected to important observational tests. This paper updates information provided in a 2000 SPIE paper on the scientific motivation and design concepts for interferometric missions SPIRIT (the Space Infrared Interferometric Telescope) and SPECS (the Submillimeter Probe of the Evolution of Cosmic Structure). SPECS is a kilometer baseline far-IR/submillimeter imaging and spectral interferometer that depends on formation flying, and SPIRIT is a highly-capable pathfinder interferometer on a boom with a maximum baseline in the 30 - 50 m range. We describe recent community planning activities, remind readers of the scientific rationale for space-based far-infrared imaging interferometry, present updated design concepts for the SPIRIT and SPECS missions, and describe the main issues currently under study. The engineering and technology requirements for SPIRIT and SPECS, additional design details, recent technology developments, and technology roadmaps are given in a companion paper in the Proceedings of the conference on New Frontiers in Stellar Interferometry.

Maintaining the Database for Information Object Analysis, Intent, Dissemination and Enhancement (IOAIDE) and the US Army Research Laboratory Campus Sensor Network (ARL CSN)

DTIC Science & Technology

2017-01-01

CII-B 2800 Powder Mill Road Adelphi, MD 20783-1138 8. PERFORMING ORGANIZATION REPORT NUMBER ARL-TR-7921 9. SPONSORING/MONITORING AGENCY NAME(S...server database, structured query language, information objects, instructions, maintenance , cursor on target events, unattended ground sensors...unlimited. iii Contents List of Figures iv 1. Introduction 1 2. Computer and Software Development Tools Requirements 1 3. Database Maintenance 2 3.1

The Gibbs Variational Method in Thermodynamics of Equilibrium Plasma: 1. General Conditions of Equilibrium and Stability for One-Component Charged Gas

DTIC Science & Technology

2018-04-01

systems containing ionized gases. 2. Gibbs Method in the Integral Form As per the Gibbs general methodology , based on the concept of heterogeneous...ARL-TR-8348 ● APR 2018 US Army Research Laboratory The Gibbs Variational Method in Thermodynamics of Equilibrium Plasma: 1...ARL-TR-8348 ● APR 2018 US Army Research Laboratory The Gibbs Variational Method in Thermodynamics of Equilibrium Plasma: 1. General

Quasi Static and Dynamic Characterization of Equal Channel Angular Extrusion (ECAE) Processed and Rolled AZ31 Magnesium Alloy Sheet

DTIC Science & Technology

2017-04-01

ARL-TR-8006 ● Apr 2017 US Army Research Laboratory Quasi -Static and Dynamic Characterization of Equal Channel Angular Extrusion...originator. ARL-TR-8006 ● Apr 2017 US Army Research Laboratory Quasi -Static and Dynamic Characterization of Equal Channel Angular...April 2017 2. REPORT TYPE Technical Report 3. DATES COVERED (From - To) April 2015–January 2016 4. TITLE AND SUBTITLE Quasi -Static and Dynamic

A Concise Physical Interpretation of Several Analytical Grueneisen Formulations

DTIC Science & Technology

2006-08-01

Formulations 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER AH80 5e. TASK NUMBER 6. AUTHOR( S ) Steven B. Segletes 5f. WORK UNIT NUMBER 7...PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN: AMSRD-ARL-WM-TD Aberdeen Proving Ground, MD 21005-5069 8...PERFORMING ORGANIZATION REPORT NUMBER ARL-TR-3881 10. SPONSOR/MONITOR’S ACRONYM( S ) 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 11

Modeling the Penetration Behavior of Rigid Into Ballistic Gelatin

DTIC Science & Technology

2008-03-01

PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER AH80 5e. TASK NUMBER 6. AUTHOR( S ) Steven B. Segletes 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION...NAME( S ) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN: AMSRD-ARL-WM-TC Aberdeen Proving Ground, MD 21005-5069 8. PERFORMING ORGANIZATION...REPORT NUMBER ARL-TR-4393 10. SPONSOR/MONITOR’S ACRONYM( S ) 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 11. SPONSOR/MONITOR’S

Analysis of Erosion Transition in Tungsten-Alloy Rods into Aluminum Targets

DTIC Science & Technology

2004-03-01

PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER AH80 5e. TASK NUMBER 6. AUTHOR( S ) Steven B. Segletes 5f. WORK UNIT NUMBER 7. PERFORMING...ORGANIZATION NAME( S ) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN: AMSRD-ARL-WM-TD Aberdeen Proving Ground, MD 21005-5066 8. PERFORMING...ORGANIZATION REPORT NUMBER ARL-TR-3153 10. SPONSOR/MONITOR’S ACRONYM( S ) 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 11. SPONSOR

Development of a Telemetry-Enabled High-G Projectile Carrier

DTIC Science & Technology

2012-09-01

of High Velocity Guns, Version 2 (IBHVG2) interior ballistics simulation • Pete Muller, ARL, helped populate the ARL sensor suite boards...differences in external characteristics between the conventional M831 and the modified M831 high-g carrier projectile can be seen in figure 3. Figure 2...of High Velocity Guns, Version 2 (IBHVG2) (6). The output values from the simulation for the selected charge weight are seen in table 2. Table 2

An Automated Energy Detection Algorithm Based on Morphological Filter Processing with a Semi-Disk Structure

DTIC Science & Technology

2018-01-01

statistical moments of order 2, 3, and 4. The probability density function (PDF) of the vibrational time series of a good bearing has a Gaussian...ARL-TR-8271 ● JAN 2018 US Army Research Laboratory An Automated Energy Detection Algorithm Based on Morphological Filter...when it is no longer needed. Do not return it to the originator. ARL-TR-8271 ● JAN 2018 US Army Research Laboratory An Automated

An Analysis of Water-to-Air Heat Pump Systems for Use in Government Facilities.

DTIC Science & Technology

1980-09-01

factories , businesses, and homes could have a significant impact on total energy con- sumption. Various methods to reduce energy consumption include...MODEL GROUND WATER HEAT PUMP 95 ECOsOioIC: EVALUATION OF 4E i Il/C 0"C". 5InULATI -’ (S 4.’V;F, TEAx3 EC3OO, tC ANALISIS -ARlE7ERS E’NNtNG Yf. OF S:h

Strategies for Characterizing the Sensory Environment: Objective and Subjective Evaluation Methods using the VisiSonic Real Space 64/5 Audio-Visual Panoramic Camera

DTIC Science & Technology

2017-11-01

ARL-TR-8205 ● NOV 2017 US Army Research Laboratory Strategies for Characterizing the Sensory Environment: Objective and...Subjective Evaluation Methods using the VisiSonic Real Space 64/5 Audio-Visual Panoramic Camera By Joseph McArdle, Ashley Foots, Chris Stachowiak, and...return it to the originator. ARL-TR-8205 ● NOV 2017 US Army Research Laboratory Strategies for Characterizing the Sensory

SMARTweave Sensors for Assessing Ballistic Damage: A Feasibility Study.

DTIC Science & Technology

1998-05-01

in transition from ARL, Watertown, MA, to the Rodman Materials Research Laboratory, Aberdeen Proving Ground (APG), MD. ii Acknowledgments The authors...BERMAN A FRYDMAN T LI W MCINTOSH E SZYMANSKI AMSRL WM MC T HYNES 4600 AMSRL WM MD W ROY 4600 AMSRL WM ME R ADLER 4600 AMSRL WM T W MORRISON 309 AMSRL...that the Materials Division was in transition from ARL, Watertown, MA, to the Rodman Materials Research Laboratory, Aberdeen Proving Ground (APG), MD

ARL Support of NRL Rocket Experiments to Investigate Ionospheric Phenomena

DTIC Science & Technology

2010-08-31

reallocate the funds to support NRL’s ongoing efforts to develop an ionospheric tomography network in South America to support the C/NOFS satellite...of NRL Rocket Experiments to Investigate Ionospheric Phenomena 5a. CONTRACT NUMBER N00173-09-1-G036 5b. GRANT NUMBER N00173-09-1-G036 5c...1-G036 ARL Support of NRL Rocket Experiments to Investigate Ionospheric Phenomena BY DR. TREVOR W. GARNER APPLIED RESEARCH LABORATORIES THE

M2 .50-cal. Multishot Capabilities at the US Army Research Laboratory

DTIC Science & Technology

2015-09-01

a platform was designed to simulate the 2-round burst of the M2 .50-caliber Browning machine gun (BMG). The 2-round-burst cyclic rate was achieved...ARL-TN-0694 ● SEP 2015 US Army Research Laboratory M2 .50-cal. Multishot Capabilities at the US Army Research Laboratory by...longer needed. Do not return it to the originator. ARL-TN-0694 ● SEP 2015 US Army Research Laboratory M2 .50-cal. Multishot

An NPSS Model of a Proposed Altitude Test Facility

DTIC Science & Technology

2011-02-01

An NPSS Model of a Proposed Altitude Test Facility by Brian C. Huffman, Thomas M. Lavelle, and Albert K. Owen ARL-RP-310 February 2011...originator. Army Research Laboratory Aberdeen Proving Ground, MD 21005-5066 ARL-RP-310 February 2011 An NPSS Model of a Proposed...January 2011 4. TITLE AND SUBTITLE An NPSS Model of a Proposed Altitude Test Facility 5a. CONTRACT NUMBER DAAB07-03-D-2389 5b. GRANT NUMBER 5c

Prediction of Wind Energy Resources (PoWER) Users Guide

DTIC Science & Technology

2016-01-01

ARL-TR-7573● JAN 2016 US Army Research Laboratory Prediction of Wind Energy Resources (PoWER) User’s Guide by David P Sauter...not return it to the originator. ARL-TR-7573 ● JAN 2016 US Army Research Laboratory Prediction of Wind Energy Resources (PoWER...2016 2. REPORT TYPE Final 3. DATES COVERED (From - To) 09/2015–11/2015 4. TITLE AND SUBTITLE Prediction of Wind Energy Resources (PoWER) User’s

An Annotated Bibliography of MANPRINT-Related Assessments and Evaluations Conducted by the U.S. Army, 2nd Edition: 1953 to 2009. Volume 2 - MANPRINT Assessment and Evaluations

DTIC Science & Technology

2010-02-01

Research Laboratory Aberdeen Proving Ground, MD 21005-5425 ARL-SR-189 February 2010 An Annotated Bibliography of MANPRINT-Related...Middlebrooks, Ph.D. Human Research and Engineering Directorate, ARL Approved for public release; distribution...7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN: RDRL-HRM-AV Fort Hood, TX 76544-5073 8. PERFORMING

Spec2Harv: Converting Spectrum output to HARVEST input

Treesearch

Eric J. Gustafson; Luke V. Rasmussen; Larry A. Leefers

2003-01-01

Spec2Harv was developed to automate the conversion of harvest schedules generated by the Spectrum model into script files that can be used by the HARVEST simulation model to simulate the implementation of the Spectrum schedules in a spatially explicit way.

Evaluation of spectrophotometric and HPLC methods for shikimic acid determination in plants: models in glyphosate-resistant and -susceptible crops.

PubMed

Zelaya, Ian A; Anderson, Jennifer A H; Owen, Micheal D K; Landes, Reid D

2011-03-23

Endogenous shikimic acid determinations are routinely used to assess the efficacy of glyphosate in plants. Numerous analytical methods exist in the public domain for the detection of shikimic acid, yet the most commonly cited comprise spectrophotometric and high-pressure liquid chromatography (HPLC) methods. This paper compares an HPLC and two spectrophotometric methods (Spec 1 and Spec 2) and assesses the effectiveness in the detection of shikimic acid in the tissues of glyphosate-treated plants. Furthermore, the study evaluates the versatility of two acid-based shikimic acid extraction methods and assesses the longevity of plant extract samples under different storage conditions. Finally, Spec 1 and Spec 2 are further characterized with respect to (1) the capacity to discern between shikimic acid and chemically related alicyclic hydroxy acids, (2) the stability of the chromophore (t1/2), (3) the detection limits, and (4) the cost and simplicity of undertaking the analytical procedure. Overall, spectrophotometric methods were more cost-effective and simpler to execute yet provided a narrower detection limit compared to HPLC. All three methods were specific to shikimic acid and detected the compound in the tissues of glyphosate-susceptible crops, increasing exponentially in concentration within 24 h of glyphosate application and plateauing at approximately 72 h. Spec 1 estimated more shikimic acid in identical plant extract samples compared to Spec 2 and, likewise, HPLC detection was more effective than spectrophotometric determinations. Given the unprecedented global adoption of glyphosate-resistant crops and concomitant use of glyphosate, an effective and accurate assessment of glyphosate efficacy is important. Endogenous shikimic acid determinations are instrumental in corroborating the efficacy of glyphosate and therefore have numerous applications in herbicide research and related areas of science as well as resolving many commercial issues as a consequence of glyphosate utilization.

Spectrophotometric Determination of Carbonate Ion Concentrations: Elimination of Instrument-Dependent Offsets and Calculation of In Situ Saturation States.

PubMed

Sharp, Jonathan D; Byrne, Robert H; Liu, Xuewu; Feely, Richard A; Cuyler, Erin E; Wanninkhof, Rik; Alin, Simone R

2017-08-15

This work describes an improved algorithm for spectrophotometric determinations of seawater carbonate ion concentrations ([CO 3 2- ] spec ) derived from observations of ultraviolet absorbance spectra in lead-enriched seawater. Quality-control assessments of [CO 3 2- ] spec data obtained on two NOAA research cruises (2012 and 2016) revealed a substantial intercruise difference in average Δ[CO 3 2- ] (the difference between a sample's [CO 3 2- ] spec value and the corresponding [CO 3 2- ] value calculated from paired measurements of pH and dissolved inorganic carbon). Follow-up investigation determined that this discordance was due to the use of two different spectrophotometers, even though both had been properly calibrated. Here we present an essential methodological refinement to correct [CO 3 2- ] spec absorbance data for small but significant instrumental differences. After applying the correction (which, notably, is not necessary for pH determinations from sulfonephthalein dye absorbances) to the shipboard absorbance data, we fit the combined-cruise data set to produce empirically updated parameters for use in processing future (and historical) [CO 3 2- ] spec absorbance measurements. With the new procedure, the average Δ[CO 3 2- ] offset between the two aforementioned cruises was reduced from 3.7 μmol kg -1 to 0.7 μmol kg -1 , which is well within the standard deviation of the measurements (1.9 μmol kg -1 ). We also introduce an empirical model to calculate in situ carbonate ion concentrations from [CO 3 2- ] spec . We demonstrate that these in situ values can be used to determine calcium carbonate saturation states that are in good agreement with those determined by more laborious and expensive conventional methods.

School Planning, Evaluation and Communication System (SPECS).

ERIC Educational Resources Information Center

Flocco, Edward C.

A comprehensive school planning tool is available from General Learning Corporation and the Center for the Advanced Study of Educational Administration at the University of Oregon. This School Planning, Evaluation and Communication System (SPECS) provides a deliverable system of training, implementation strategies and materials and technical…

New species in the family Ctenidae Keyserling, 1877 from high altitude habitats in Myanmar, with the first case of penetration of the female's cuticle by a male in the RTA-clade (Arachnida: Araneae: Ctenidae).

PubMed

Jäger, Peter; Minn, Myin Zu

2015-07-31

Specimens of the spider genera Ctenus Walckenaer, 1805 and Anahita Karsch, 1879 from Myanmar were investigated. Three species are described as new to science: Anahita popa spec. nov. (female; Mt Popa), Ctenus natmataung spec. nov. (male, female; Mt Victoria) and C. pingu spec. nov. (male, female; Mt Victoria). The female of C. cladarus Jäger, 2012 is described for the first time. Males of C. natmataung spec. nov. possess an easily breakable tip of their RTA. Two cases are reported where this part was clinging to the epigyne and a pointed appendix had penetrated the female's cuticle. This is the first such case reported within the RTA-clade. All three Ctenus spp. have very similar copulatory organs and are interpreted as a product of relatively recent speciation events. According to their elevational zonation, the driving factor for this speciation could be different climatic conditions at different elevations.

Characterization and calibration of a viscoelastic simplified potential energy clock model for inorganic glasses

DOE PAGES

Chambers, Robert S.; Tandon, Rajan; Stavig, Mark E.

2015-07-07

In this study, to analyze the stresses and strains generated during the solidification of glass-forming materials, stress and volume relaxation must be predicted accurately. Although the modeling attributes required to depict physical aging in organic glassy thermosets strongly resemble the structural relaxation in inorganic glasses, the historical modeling approaches have been distinctly different. To determine whether a common constitutive framework can be applied to both classes of materials, the nonlinear viscoelastic simplified potential energy clock (SPEC) model, developed originally for glassy thermosets, was calibrated for the Schott 8061 inorganic glass and used to analyze a number of tests. A practicalmore » methodology for material characterization and model calibration is discussed, and the structural relaxation mechanism is interpreted in the context of SPEC model constitutive equations. SPEC predictions compared to inorganic glass data collected from thermal strain measurements and creep tests demonstrate the ability to achieve engineering accuracy and make the SPEC model feasible for engineering applications involving a much broader class of glassy materials.« less

[Comparative study between the level of discomfort and the acoustic reflex in workers].

PubMed

Bezerra, Francisca Magnólia Diógenes Holanda; Iório, Maria Cecília Martinelli

2006-01-01

Comparative study between the level of discomfort and the acoustic reflex in workers. To observe the hearing behavior, through the assessment of the contraction activity of the stapedius muscle and the level of discomfort, of individuals who are and are not exposed to occupational noise, with the aim of identifying the influence of noise in the behavior of the contraction of the stapedius muscle and in the sensibility of hearing. This study was developed at the Serviço Social da Indústria - SESI - Ce. A hundred and three adults with normal hearing, male and female, with ages varying from 18 to 45 years were divided in three groups: G1 with 41 adults exposed to noise and who used AIPE; G2 with 32 adults exposed to noise and who did not use AIPE; G3 with 30 adults who were not exposed to noise. Participants were submitted to audiologic evaluation, including the analysis of the acoustic reflex level (ARL) and discomfort level (DL) at the frequencies of 500 HZ, 1000Hz, 2000Hz, 3000Hz, 4000Hz and WN. For the statistical analysis the tests of Mann Whitney, Wilcoxon and Kruskal, with significance levels of 5%, were used. No statistically significant difference was identified for the ARL between the three groups, with mean values ranging from 93 to 103dBHL; the ARL was significantly smaller than the DL, with the mean values of DL varying from 111 to 119 dBHL for G1, from 113 to 120dBHL for G2 and from 106 to 114dBHL for G3; the DL is higher in individuals of G1 followed by individuals of G2 and G3. The exposure to noise does not determine changes in the behavior of the ARL; the DL rises with the exposure to occupational noise; the DL is higher than the ARL in 10 to 25dB.

Optimization of Micro-Spec, an Ultra-Compact High-Performance Spectrometer for Far-Infrared Astronomy

NASA Astrophysics Data System (ADS)

Cataldo, Giuseppe; Moseley, S. H.; Wollack, E.; Hsieh, W.; Huang, W.; Stevenson, T.

2013-06-01

Micro-Spec (µ-Spec) is a high-sensitivity direct-detection spectrometer operating in the far-infrared and submillimeter regime. When combined with a cryogenic telescope, it provides an enabling technology for studying the epoch of reionization and initial galaxy formation. As a direct-detection spectrometer, µ-Spec can provide high sensitivity under the low background conditions provided by cryogenic telescopes such as the space infrared telescope for cosmology and astrophysics SPICA. The µ-Spec modules use low-loss superconducting microstrip transmission lines implemented on a single 4-inch-diameter wafer. Such a dramatic size reduction is enabled by the use of silicon, a material with an index of refraction about three times that of vacuum, which thus allows the microstrip lines to be one third their vacuum length. Using a large number of modules as well as reducing the negative effects of stray light also contributes positively to the enhanced sensitivity of such an instrument. µ-Spec can be compared to a grating spectrometer, in which the phase retardation generated by the reflection from the grating grooves is instead produced by propagation through transmission lines of different length. The µ-Spec optical design is based on the stigmatization and minimization of the light path function in a two-dimensional diffractive region. The power collected through a broadband antenna is progressively divided by binary microstrip power dividers. The position of the radiators is selected to provide zero phase errors at two stigmatic points, and a third stigmatic point is generated by introducing a differential phase shift in each radiator. To optimize the overall efficiency of the instrument, the emitters are directed to the center of the focal surface. A point design was developed for initial demonstration. Because of losses to other diffraction orders, the efficiency of the design presented is about 30%. Design variations on this implementation are illustrated which can lead to near-unit efficiency and will be the basis of future instruments. Measurements are being conducted to validate the designs.

User Guide: How to Use and Operate Virtual Reality Equipment in the Systems Assessment and Usability Laboratory (SAUL) for Conducting Demonstrations

DTIC Science & Technology

2017-08-01

ARL-TN-0839 ● AUG 2017 US Army Research Laboratory User Guide: How to Use and Operate Virtual Reality Equipment in the Systems...ARL-TN-0839 ● AUG 2017 US Army Research Laboratory User Guide: How to Use and Operate Virtual Reality Equipment in the Systems...September 2017 4. TITLE AND SUBTITLE User Guide: How to Use and Operate Virtual Reality Equipment in the Systems Assessment and Usability Laboratory

Research@ARL. Volume 4, Issue 1, November 2015

DTIC Science & Technology

2015-11-01

Durham, NC • Orlando, FL Visit ARL’s web site at www.arl.army.mil 3 FOREWORD Dr. Thomas P. Russell Director, U.S. Army Research Laboratory Thank you...either to sense or to communicate. This volume presents papers in all of these areas: the generation of light energy; the detection of light energy...present papers in all of these areas: the generation of light energy, the detection of light energy, the use of light to measure and sense, and the

Study of the Bistatic Radar Cross Section of a 155-mm Artillery Round

DTIC Science & Technology

2017-06-01

study . Section 3 compares the accuracy of the 2 EM modeling software packages used in this work. In Section 4, we discuss the relevant Approved for...ARL-TR-8045 ● JUNE 2017 US Army Research Laboratory Study of the Bistatic Radar Cross Section of a 155-mm Artillery Round by...when it is no longer needed. Do not return it to the originator. ARL-TR-8045 ● JUNE 2017 US Army Research Laboratory Study of the

Ectoderm gene activation in sea urchin embryos mediated by the CCAAT-binding factor.

PubMed

Li, Xiaotao; Bhattacharya, Chitralekha; Dayal, Sandeep; Maity, Sankar; Klein, William H

2002-05-01

Transcriptional enhancers are short stretches of DNA that function to achieve highly specific patterns of gene expression. To identify the mechanisms by which enhancers achieve their specificity, we made use of an enhancer from the aboral ectoderm-specific spec2a gene of the sea urchin Strongylocentrotus purpuratus. The spec2a enhancer contains five cis-regulatory elements within 78 base pairs that interact with five distinct DNA-binding proteins to confer aboral ectoderm expression. Here, we present an analysis of the sea urchin CCAAT binding factor (CBF), which binds to a CCAAT motif within the spec2a enhancer. S. purpuratus CBF and SpOtx, a ubiquitously expressed factor, act together at closely placed cis-regulatory elements to mediate spec2a transcription in the ectoderm. SpCBF was the sole factor that bound to the spec2a CCAAT element, and two of the three subunits that make up the CBF holoprotein were cloned and shown to have high sequence conservation with their vertebrate orthologs. Based on its involvement in the regulation of several other sea urchin genes, SpCBF appears to be a major transcription factor in the sea urchin embryo for positive regulation of ectoderm gene expression. In addition to its role in vertebrate cell growth and proliferation, our results indicate that CBF also functions at the early stages of germ layer formation, namely ectoderm differentiation.

Discovery of novel Pim-1 kinase inhibitors by a hierarchical multistage virtual screening approach based on SVM model, pharmacophore, and molecular docking.

PubMed

Ren, Ji-Xia; Li, Lin-Li; Zheng, Ren-Lin; Xie, Huan-Zhang; Cao, Zhi-Xing; Feng, Shan; Pan, You-Li; Chen, Xin; Wei, Yu-Quan; Yang, Sheng-Yong

2011-06-27

In this investigation, we describe the discovery of novel potent Pim-1 inhibitors by employing a proposed hierarchical multistage virtual screening (VS) approach, which is based on support vector machine-based (SVM-based VS or SB-VS), pharmacophore-based VS (PB-VS), and docking-based VS (DB-VS) methods. In this approach, the three VS methods are applied in an increasing order of complexity so that the first filter (SB-VS) is fast and simple, while successive ones (PB-VS and DB-VS) are more time-consuming but are applied only to a small subset of the entire database. Evaluation of this approach indicates that it can be used to screen a large chemical library rapidly with a high hit rate and a high enrichment factor. This approach was then applied to screen several large chemical libraries, including PubChem, Specs, and Enamine as well as an in-house database. From the final hits, 47 compounds were selected for further in vitro Pim-1 inhibitory assay, and 15 compounds show nanomolar level or low micromolar inhibition potency against Pim-1. In particular, four of them were found to have new scaffolds which have potential for the chemical development of Pim-1 inhibitors.

Spectral Classification of Heavily Reddened Stars by CO Absorption Strength

NASA Astrophysics Data System (ADS)

Garling, Christopher; Bary, Jeffrey S.; Huard, Tracy L.

2017-01-01

The nature of dust grains in dense molecular clouds can be explored by obtaining spectra of giant stars located behind the clouds and examining the wavelength-dependent attentuation of their light. This approach requires the intrinsic spectra of the background stars to be known, which can be achieved by determining their spectral types. In the K-band spectra of cool giant stars, several temperature-sensitive CO absorption bands serve as good spectral type indicators. Taking advantage of the SpeX Infrared Telescope Facility Spectral Library, near-infrared spectra collected with TripleSpec and the 3.5-meter ARC Telescope at Apache Point Observatory, and a previously constructed CO spectral index, we make precise spectral determinations of 20 giant stars located behind two dense cloud cores: CB188 and L429C. With spectral types in hand, we then utilize Markov Chain Monte Carlo techniques to constrain extinctions along these lines of sight. The spectral typing method will be described and assessed as well as its success at finding a couple of incorrectly spectral typed stars in the SpeX Library. Funding for this program was provided by a NSF REU grant to the Keck Northeast Astronomy Consortium and a grant from the NASA Astrophysics Data Analysis Program.

SPECS 2. Component Two: Program Budgeting and Cost Accounting.

ERIC Educational Resources Information Center

DuVall, Lloyd A.

The School Planning, Evaluation, and Communication System (SPECS) is an overall design for districtwide program assessment and development. It is both a way of interrelating planning and evaluation of individual programs and a way of comparing the outcomes of all district programs with the district's community-defined educational goals. Component…

A critical look at prospective surveillance using a scan statistic.

PubMed

Correa, Thais R; Assunção, Renato M; Costa, Marcelo A

2015-03-30

The scan statistic is a very popular surveillance technique for purely spatial, purely temporal, and spatial-temporal disease data. It was extended to the prospective surveillance case, and it has been applied quite extensively in this situation. When the usual signal rules, as those implemented in SaTScan(TM) (Boston, MA, USA) software, are used, we show that the scan statistic method is not appropriate for the prospective case. The reason is that it does not adjust properly for the sequential and repeated tests carried out during the surveillance. We demonstrate that the nominal significance level α is not meaningful and there is no relationship between α and the recurrence interval or the average run length (ARL). In some cases, the ARL may be equal to ∞, which makes the method ineffective. This lack of control of the type-I error probability and of the ARL leads us to strongly oppose the use of the scan statistic with the usual signal rules in the prospective context. Copyright © 2014 John Wiley & Sons, Ltd.

Joint Networking Command and Control (C2) Communications Among Distributed Operations, JCAS, and Joint Fires

DTIC Science & Technology

2007-06-01

fasteners. Enviromental Spec Storage Temperature: -26 to 160 °F, Operating Temperature: -22 to 160 °F, Operating Humidity Range: 5% to 100% Non...Accessories Double 90° tongue and groove case design, with anti-tamper fasteners. Enviromental Spec Storage Temperature: -26 to 160 °F, Operating

"FluSpec": A Simulated Experiment in Fluorescence Spectroscopy

ERIC Educational Resources Information Center

Bigger, Stephen W.; Bigger, Andrew S.; Ghiggino, Kenneth P.

2014-01-01

The "FluSpec" educational software package is a fully contained tutorial on the technique of fluorescence spectroscopy as well as a simulator on which experiments can be performed. The procedure for each of the experiments is also contained within the package along with example analyses of results that are obtained using the software.

STS-60 crew walkout from O&C

NASA Image and Video Library

1994-02-03

STS-60 pilot Ken Reightler (front left) and Mission Commander Charlie Bolden (front right) lead the way from the O&C bldg. enroute to Discovery at Pad 39A. Behidn are (from felt) Mission Specs Sega adn Krikalev: Payload Commander Chang-Diaz: and Misssion Spec Davis. (Op. No. D6022)(Item D-112C)

Collection Development Organization and Committees. SPEC Kit 11.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This kit focuses on information that is useful for starting a collection development program. It contains 7 position descriptions, 10 documents on the role of committees, 4 organization charts, 5 documents on the organization of functions, and an analysis of a Systems and Procedures Exchange Center (SPEC) collection development survey. The survey,…

DFT algorithms for bit-serial GaAs array processor architectures

NASA Technical Reports Server (NTRS)

Mcmillan, Gary B.

1988-01-01

Systems and Processes Engineering Corporation (SPEC) has developed an innovative array processor architecture for computing Fourier transforms and other commonly used signal processing algorithms. This architecture is designed to extract the highest possible array performance from state-of-the-art GaAs technology. SPEC's architectural design includes a high performance RISC processor implemented in GaAs, along with a Floating Point Coprocessor and a unique Array Communications Coprocessor, also implemented in GaAs technology. Together, these data processors represent the latest in technology, both from an architectural and implementation viewpoint. SPEC has examined numerous algorithms and parallel processing architectures to determine the optimum array processor architecture. SPEC has developed an array processor architecture with integral communications ability to provide maximum node connectivity. The Array Communications Coprocessor embeds communications operations directly in the core of the processor architecture. A Floating Point Coprocessor architecture has been defined that utilizes Bit-Serial arithmetic units, operating at very high frequency, to perform floating point operations. These Bit-Serial devices reduce the device integration level and complexity to a level compatible with state-of-the-art GaAs device technology.

Evaluating pictogram prediction in a location-aware augmentative and alternative communication system.

PubMed

Garcia, Luís Filipe; de Oliveira, Luís Caldas; de Matos, David Martins

2016-01-01

This study compared the performance of two statistical location-aware pictogram prediction mechanisms, with an all-purpose (All) pictogram prediction mechanism, having no location knowledge. The All approach had a unique language model under all locations. One of the location-aware alternatives, the location-specific (Spec) approach, made use of specific language models for pictogram prediction in each location of interest. The other location-aware approach resulted from combining the Spec and the All approaches, and was designated the mixed approach (Mix). In this approach, the language models acquired knowledge from all locations, but a higher relevance was assigned to the vocabulary from the associated location. Results from simulations showed that the Mix and Spec approaches could only outperform the baseline in a statistically significant way if pictogram users reuse more than 50% and 75% of their sentences, respectively. Under low sentence reuse conditions there were no statistically significant differences between the location-aware approaches and the All approach. Under these conditions, the Mix approach performed better than the Spec approach in a statistically significant way.

Speech-driven environmental control systems--a qualitative analysis of users' perceptions.

PubMed

Judge, Simon; Robertson, Zoë; Hawley, Mark; Enderby, Pam

2009-05-01

To explore users' experiences and perceptions of speech-driven environmental control systems (SPECS) as part of a larger project aiming to develop a new SPECS. The motivation for this part of the project was to add to the evidence base for the use of SPECS and to determine the key design specifications for a new speech-driven system from a user's perspective. Semi-structured interviews were conducted with 12 users of SPECS from around the United Kingdom. These interviews were transcribed and analysed using a qualitative method based on framework analysis. Reliability is the main influence on the use of SPECS. All the participants gave examples of occasions when their speech-driven system was unreliable; in some instances, this unreliability was reported as not being a problem (e.g., for changing television channels); however, it was perceived as a problem for more safety critical functions (e.g., opening a door). Reliability was cited by participants as the reason for using a switch-operated system as back up. Benefits of speech-driven systems focused on speech operation enabling access when other methods were not possible; quicker operation and better aesthetic considerations. Overall, there was a perception of increased independence from the use of speech-driven environmental control. In general, speech was considered a useful method of operating environmental controls by the participants interviewed; however, their perceptions regarding reliability often influenced their decision to have backup or alternative systems for certain functions.

Theoretical Prediction of the Heat of Formation, Density, and Relative Sensitivity for 3,7-dinitro-[1,2,4]triazolo[5,1-c][1,2,4] triazin-4-amine

DTIC Science & Technology

2015-06-01

the procedures used to generate this information, as well as Cheetah calculations using the predicted crystalline density and heat of formation. 15...overlay ...............6 List of Tables Table Cheetah -predicted properties of the 3,7-dinitro-[1,2,4]triazolo[5,1- c][1,2,4]triazin-4-amine molecule...script, initially written for the ARL DSRC. Dr Rice is acknowledged for running the Cheetah calculations. All computations were performed at the ARL

A Simple Data Logging System for Ballistic Applications

DTIC Science & Technology

2006-07-01

6. AUTHOR(S) Thomas Kottke 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) U.S. Army Research Laboratory ATTN...AMSRD-ARL-WM-TE Aberdeen Proving Ground, MD 21005-5066 8. PERFORMING ORGANIZATION REPORT NUMBER ARL-TR-3853 10. SPONSOR/MONITOR’S ACRONYM(S...IC2 PIC18F458-I/L-ND $185.50/25 IC SOCKET PLCC 44POS SMT for IC2 ED80010-ND $15.05/10 IC SRAM 512KX8 LP WIDE 32- SOIC IC1 and IC4 428-1075-ND $118.00

Real-time evaluation of tissue vitality by monitoring of microcirculatory blood flow, HbO2, and mitochondrial NADH redox state

NASA Astrophysics Data System (ADS)

Deutsch, Assaf; Pevzner, Eliyahu; Jaronkin, Alex; Mayevsky, Avraham

2004-06-01

Monitoring of tissue vitality (oxygen supply/demand) in real time is very rare in clinical practice although its use as an early warning alarming system, for clinical care medicine, is very practical. In our previous communication (SPIE 2003) we described the Tissue Spectroscope - TiSpec02, by which tissue microcirculatory blood flow (TBF) and mitochondrial NADH fluorescence were measured using a single light source (390nm). In order to improve the measurement capabilities as well as to decrease dramatically the size and cost of this clinical device, we have changed the TiSpec02 into a multi-wavelength illumination system in the new TiSpec03. In order to measure microcirculatory blood flow by laser Doppler flowmetry we used a 785nm laser diode. For mitochondrial NADH fluorescence measurement we adopted the 370nm LED. For the determination of the oxygenation level of hemoglobin (HbO2) we used the 2-wavelength reflectance technique. This new monitored parameter that was added to the TiSpec03 increases the accuracy of the diagnosis of tissue vitality. The bundle of optical fibers used to connect the tissue to the TiSpec03, was integrated into a special anchoring methodology depending on the monitored tissue or organ. In order to test the performance of the improved TiSpec we have used it in experimental animals brain models exposed to various pathophysiological conditions. Rats and gerbils were anesthetized and the fiber optic probe was located epidurally used dental acrylic cement. During anoxia and ischemia the lack of O2 led to a clear decrease in TBF and HbO2 while NADH shows a large elevation. When brain activation was induced by cortical spreading depression (SD), the elevated O2 consumption was recorded as a large oxidation (decrease) of mitochondrial NADH while TBF increase dramatically. Blood HbO2 was not affected significantly by the SD wave.

Morphology and small-subunit rRNA gene sequences of two novel marine ciliates, Metanophrys orientalis spec. nov. and Uronemella sinensis spec. nov. (Protista, Ciliophora, Scuticociliatia), with an improved diagnosis of the genus Uronemella.

PubMed

Pan, Xuming; Zhu, Mingzhuang; Ma, Honggang; Al-Rasheid, Khaled A S; Hu, Xiaozhong

2013-09-01

The morphology and infraciliature of two novel marine scuticociliates, Metanophrys orientalis spec. nov. and Uronemella sinensis spec. nov., collected from sandy beaches at Qingdao, China, were investigated using live observation and protargol-staining methods. Metanophrys orientalis spec. nov. is distinguished by the following characteristics: marine habitat and a slender to elongate oval body with pointed anterior end and rounded caudal end, in vivo about 25-50 µm long; buccal field about a quarter to a third of body length; nine or ten somatic kineties with dikinetids approximately in anterior half of body, monokinetids in posterior half; membranelles 1 and 2 almost equal in length and composed of two and three longitudinal rows of kinetids respectively; paroral membrane with zigzag structure extending anteriorly to middle portion of membranelle 2; contractile vacuole pore located at posterior end of somatic kinety 1. The genus Uronemella is redefined as follows: marine form with an elongate-elliptical or inverted pear-shaped body; apical plate conspicuous; buccal field about two-thirds of body length, cytostome subequatorially located; oral apparatus Uronema-like; somatic kineties comprising a mixture of dikinetids and monokinetids. Uronemella sinensis spec. nov. is recognized by having an elongate-elliptical body with truncated apical frontal plate, size in vivo about 25-35 × 15-20 µm, nine or ten somatic kineties, membranelle 1 consisting of two or three basal bodies, contractile vacuole pore at posterior end of somatic kinety 1. This study also compared the small-subunit rRNA gene sequences of these two species with other closely related species to show the sequence divergence, which ranged from 3.53 to 9.60%. Phylogenetic analyses support the contention that the genus Uronemella is monophyletic, while Metanophrys is non-monophyletic.

Response evaluation after primary systemic therapy of Her2 positive breast cancer – an observational cross-sectional study.

PubMed

Tőkés, Tímea; Szentmártoni, Gyöngyvér; Torgyík, László; Kajáry, Kornélia; Lengyel, Zsolt; Györke, Tamás; Molnár, Béla Á; Tőkés, Anna-Mária; Kulka, Janina; Dank, Magdolna

2015-04-01

To evaluate (I) trastuzumab-containing primary systemic therapy (PST) in human epidermal growth factor receptor 2 (Her2) overexpressing breast carcinomas.; (II) compare the patients who achieved and those who did not achieve pathological complete remission (pCR), and (III) analyze the accuracy of different clinical-imaging modalities in tumor response monitoring. 188 patients who received PST between 2008 and 2014 were reviewed and 43 Her2 overexpressing breast cancer patients (28 Luminal B/Her2-positive and 15 Her2-positive) were enrolled. 26 patients received mostly taxane-based PST without trastuzumab (Group 1) and 17 patients received trastuzumab-containing PST (Group 2). We compared the concordance between pCR and complete remission (CR) defined by breast-ultrasound, CR defined by standard 18F-fluoro-deoxy-glucose positron emission tomography and computerized tomography (FDG-PET/CT) criteria (Method 1) and CR defined by a novel, breast cancer specific FDG-PET/CT criteria (Method 2). Sensitivity (sens), specificity (spec), and positive (PPV) and negative predictive values (NPV) were calculated. Ten patients (38.5%) in Group 1 and eight (47%) in Group 2 achieved pCR. pCR was significantly more frequent in Her2-positive than in Luminal B/Her2-positive tumors in both Group 1: (P=0.043) and Group 2: (P=0.029). PET/CT evaluated by the breast cancer specific criteria (Method 2) differentiated pCR from non-pCR more accurately in both groups (Group 1: sens=77.8%, spec=%, PPV=100%, NPV=71.4%; Group 2: sens=87.5%, spec=62.5%, PPV=70%, NPV=83.3%) than standard PET/CT criteria (Method 1) (Group 1: sens=22.2% spec=100% PPV=100% NPV=41.7%; in Group 2: sens=37.5%, spec=87.5%, PPV=75% NPV=58.3%) or breast ultrasound (Group 1, sens=83.3% spec=25% PPV=62.5% NPV=50%; Group 2, sens=100% spec=12.5% PPV=41.6% NPV=100%). The benefit of targeted treatment with trastuzumab-containing PST in Her2 overexpressing breast cancer was defined in terms of pCR rate. Luminal B/Her2-positive subtype needs further subdivision to identify patients who would benefit from PST. Combined evaluation of tumor response by our novel, breast cancer specific FDG-PET/CT criteria accurately differentiated pCR from non-pCR patients.

Alternative methods of refraction: a comparison of three techniques.

PubMed

Smith, Kyla; Weissberg, Erik; Travison, Thomas G

2010-03-01

In the developing world, refractive error is a common untreated cause of visual impairment. Lay people may use portable tools to overcome this issue. This study compares three methods of measuring spherical refractive error (SE) performed by a lay technician to a subjective refraction (SR) in a controlled clinical setting and a field trial. Fifty subjects from Boston, MA (mean age, 24.3 y ± 1.5) and 50 from Nicaragua (mean age, 40 y ± 13.7) were recruited. Measures (performed on right eye only) included (1) AdSpecs, adjustable spectacles; (2) Focometer, focusable telescope; (3) Predetermined Lens Refraction (PLR), prescripted lens choices; (4) SR. Examiners were masked and techniques randomized. Student t-test compared mean SE determined by each method (95% confidence intervals). AdSpecs repeatability was evaluated by repeating measures of SE and visual acuity (VA). Mean (SD) SE for Boston subjects determined by SR was -2.46 D (3.2). Mean (SD) SE for AdSpecs, Focometer -2.41 D (2.69), -2.80 D (2.82). Among the 30 Boston subjects considered in analyses of PLR data (see Methods), PLR and SR obtained mean (SD) values of -0.65 D (1.36) and -0.41 D (1.67), respectively, a statistically significant difference of -0.24 D (p = 0.046, t = 2.09). Mean PLR SE had greatest deviation from SR, 0.67 D. 20/20 VA was achieved by SR, AdSpecs, Focometer, and PLR in 98, 88, 84, 96% of subjects. Mean (SD) SE for Nicaragua subjects determined by SR was +0.51 D (0.71). Mean (SD) SE for AdSpecs, Focometer, and PLR was +0.68 D (0.83), +0.42 D (1.13), +0.27 D (0.79). Mean PLR SE had the greatest deviation from the SR by 0.24 D, which was a statistically significant difference. 20/20 VA was achieved by SR, AdSpecs, Focometer, and PLR in 78, 66, 66, 88% of subjects. Repeated measures by AdSpecs were highly correlated. Although the mean value obtained by each technique may be similar to that obtained by SR, substantial and clinically meaningful differences may exist in some individuals; however, where SR is unavailable they could be a feasible alternative.

Noninvasive Tests Do Not Accurately Differentiate Nonalcoholic Steatohepatitis From Simple Steatosis: A Systematic Review and Meta-analysis.

PubMed

Verhaegh, Pauline; Bavalia, Roisin; Winkens, Bjorn; Masclee, Ad; Jonkers, Daisy; Koek, Ger

2018-06-01

Nonalcoholic fatty liver disease is a rapidly increasing health problem. Liver biopsy analysis is the most sensitive test to differentiate between nonalcoholic steatohepatitis (NASH) and simple steatosis (SS), but noninvasive methods are needed. We performed a systematic review and meta-analysis of noninvasive tests for differentiating NASH from SS, focusing on blood markers. We performed a systematic search of the PubMed, Medline and Embase (1990-2016) databases using defined keywords, limited to full-text papers in English and human adults, and identified 2608 articles. Two independent reviewers screened the articles and identified 122 eligible articles that used liver biopsy as reference standard. If at least 2 studies were available, pooled sensitivity (sens p ) and specificity (spec p ) values were determined using the Meta-Analysis Package for R (metafor). In the 122 studies analyzed, 219 different blood markers (107 single markers and 112 scoring systems) were identified to differentiate NASH from simple steatosis, and 22 other diagnostic tests were studied. Markers identified related to several pathophysiological mechanisms. The markers analyzed in the largest proportions of studies were alanine aminotransferase (sens p , 63.5% and spec p , 74.4%) within routine biochemical tests, adiponectin (sensp, 72.0% and spec p , 75.7%) within inflammatory markers, CK18-M30 (sens p , 68.4% and spec p , 74.2%) within markers of cell death or proliferation and homeostatic model assessment of insulin resistance (sens p , 69.0% and spec p , 72.7%) within the metabolic markers. Two scoring systems could also be pooled: the NASH test (differentiated NASH from borderline NASH plus simple steatosis with 22.9% sens p and 95.3% spec p ) and the GlycoNASH test (67.1% sens p and 63.8% spec p ). In the meta-analysis, we found no test to differentiate NASH from SS with a high level of pooled sensitivity and specificity (≥80%). However, some blood markers, when included in scoring systems in single studies, identified patients with NASH with ≥80% sensitivity and specificity. Replication studies and more standardized study designs are urgently needed. At present, no marker or scoring system can be recommended for use in clinical practice to differentiate NASH from simple steatosis. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

Z-Spec: A broadband spectrometer for millimeter-wave astrophysics---Instrument development and results of a molecular line survey of nearby star-forming galaxy NGC 253

NASA Astrophysics Data System (ADS)

Earle, Lieko

We have built Z-Spec, a broadband spectrometer for millimeter-wave astrophysics. The instrument's instantaneous bandwidth of 185-305 GHz covers the entire 1 millimeter atmospheric transmission window with a moderate resolving power ( R = n/Dn) of 250-350. The spectrometer employs a novel architecture called WaFIRS (Waveguide Far-Infrared Spectrometer) which confines the light propagation for a curved diffraction grating within a parallel-plate waveguide, resulting in a minimum mechanical envelope. An array of 160 silicon- nitride micromesh bolometers is cooled to 60 mK via an adiabatic demagnetization refrigerator (ADR) backed by a closed-cycle 3 He- 4 He sorption pump refrigerator. Z-Spec's compact design serves as a concept demonstration for a future far-infrared spectrometer aboard a cold telescope in space. Routine observations with Z-Spec from the Caltech Submillimeter Observatory on Mauna Kea have been conducted since April 2006, and the instrument currently achieves good sensitivities that are within a factor of two of the photon background limit set by the atmosphere and telescope. Z-Spec's primary science objectives are to determine the redshifts of faint submillimeter galaxies using the 12 CO rotational ladder, and to conduct systematic line surveys of local galaxies. The millimeter waveband hosts low- to mid- J rotational transitions for several molecular species which trace the dense interstellar gas associated with active star formation. Z-Spec's bandwidth offers a unique advantage over the traditional single-dish heterodyne approach: the spectral lines and the corresponding continua are all observed simultaneously, greatly reducing relative uncertainties in flux calibration and line-to-continuum ratios. The starburst galaxy NGC 253 was observed with Z-Spec in November 2006, for a total integration of 3.49 hours over two nights. NGC 253 is one of the brightest neighbors outside the Local Group of galaxies and its compact nuclear region is a site of prodigious star-formation. Twenty-one transitions in 13 species were detected at greater than 3s, including the well-known density tracers HCO + , HCN, HNC, and three transitions of CS. The results are compared with large-velocity-gradient (LVG) radiative-transfer simulations and the implications for the physical conditions of the gas in the starburst core are discussed.

United States Air Force Analysis Extract AFSC 2A6X4 Aircraft Fuel Systems (Active Duty)

DTIC Science & Technology

2001-02-01

8217AFOMS (AETC) Randolph AFB TX’ V0226 Spec tools/equip use/oper - Rollers or Stitchers ACTIVE...8217AFOMS (AETC) Randolph AFB TX’ V0226 Spec tools/equip use/oper - Rollers or Stitchers ...equip use/oper - Rollers or Stitchers USAFE AETC PACAF AFSOC ACC AMC AFMC

Evaluation of the Alexon-Trend ProSpecT Campylobacter Microplate Assay

PubMed Central

Tolcin, Rita; LaSalvia, Margaret M.; Kirkley, Barbara A.; Vetter, Emily A.; Cockerill, Franklin R.; Procop, Gary W.

2000-01-01

We evaluated stool specimens known to contain or be free of Campylobacter by traditional culture, using the ProSpecT Campylobacter microplate assay (Alexon-Trend, Ramsey, Minn.). This rapid enzyme immunoassay for the detection of Campylobacter-specific antigens demonstrated 96% sensitivity and 99% specificity and is an acceptable alternative method of Campylobacter detection. PMID:11015419

Improved sample manipulation at the STRESS-SPEC neutron diffractometer using an industrial 6-axis robot for texture and strain analyses

NASA Astrophysics Data System (ADS)

Randau, C.; Brokmeier, H. G.; Gan, W. M.; Hofmann, M.; Voeller, M.; Tekouo, W.; Al-hamdany, N.; Seidl, G.; Schreyer, A.

2015-09-01

The materials science neutron diffractometer STRESS-SPEC located at FRM II is a dedicated instrument for strain and pole figure measurements. Both methods make complementary demands on sample handling. On one hand pole figure measurements need a high degree of freedom to orient small samples and on the other hand in strain investigations it is often necessary to handle large and heavy components. Therefore a robot based sample positioning system was developed, which has the capability to provide both possibilities. Based on this new robot system further developments like a full automated sample changer system for texture measurements were accomplished. Moreover this system opens the door for combined strain and texture analysis at STRESS-SPEC.

[Features of Acquired Immunodeficiency Syndrome-related Lymphoma on (18)F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography].

PubMed

Niu, Na; Zhu, Zhao-hui; Ma, Yan-ru; Xing, Hai-qun; Li, Fang

2015-10-01

To analyze the imaging features of (18)F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography(PET)/computed tomography (CT) in acquired immune deficiency syndrome-related lymphoma (ARL) patients correlated with their clinical signs, symptoms, and treatments. Five ARL patients underwent ¹⁸F-FDG PET/CT at Peking Union Medical College Hospital from October 2008 to January 2013. Two patients received two additional follow-up studies 6 months later. Among these 5 patients, ¹⁸FDG-PET/CT helped in diagnosis of two patient and changed therapeutic strategy in other two patients. In two patients underwent ¹⁸F-FDG PET/CT brain scans, low-metabolism lesion was newly found in cerebral cortex. Of 4 patients receiving highly active antiretroviral therapy, PET/CT also demonstrated diffusely elevated ¹⁸F-FDG uptake in subcutaneous adipose tissue in two patients. ¹⁸F-FDG PET/CT is a highly useful tool in the diagnosis and treatment of ARL patients, in particular in the identification of associated encephalopathy and lipodystrophy.

Design and Performance of Micro-Spec, an Ultra Compact High-Sensitivity Far-Infrared Spectrometer for SPICA

NASA Technical Reports Server (NTRS)

Cataldo, Giuseppe; Moseley, S. H.; Hsieh, W.-T.; Huang, W,-C,; Stevenson, T. R.; Wollak, E. J.

2012-01-01

Micro-Spec (u-Spec) is a high-performance spectrometer working in the 250-700-micrometer wavelength range, whose modules use low-loss superconducting microstrip transmission lines on a single 4-inch-diameter silicon wafer. Creating the required phase delays in transmission lines rather than free space allows such an instrument to have, in principle, the performance of a meter-scale grating spectrometer. Such a dramatic size reduction enables classes of instruments for space that would be impossible with conventional technologies. This technology can dramatically enhance the long-wavelength capability of the space infrared telescope for cosmology and astrophysics SPICA. u-Spec is analogous to a grating spectrometer. The phase retardation generated by the reflection from the grating grooves is instead produced by propagation through a transmission line. The power received by a broadband antenna is progressively divided by binary microstrip power dividers, and the required phase delays are generated by different lengths of microstrip transmission lines. by arranging these outputs along a circular focal surface, the analog of a Rowland spectrometer can he created. The procedure to optimize the Micro-Spec design is based on the stigmatization and minimization of the light path function in a two-dimensional hounded region, which results in an optimized geometry arrangement with three stigmatic points. In addition, in order to optimize the overall efficiency of the instrument, the emitters are directed to the center of the focal surface. The electric field amplitude and phase as well as the power transmitted and absorbed throughout the region are analyzed. Measurements are planned in late summer to validate the designs.

Verifiable Task Assignment and Scheduling Controller

DTIC Science & Technology

2017-07-01

15 Figure 8. Summary of results for NASA -TLX overall workload and individual...using the NASA Task Load Index ( NASA -TLX; Hart & Staveland, 1988), which was completed using a computerized version of the questionnaire. The...filled out the NASA -TLX. Then prior to the second trial, participants were trained on how to use SPEC. SPEC training consisted of: an explanation of the

Rotational Analysis of FTIR Spectra from Cigarette Smoke: An Application of Chem Spec II Software in the Undergraduate Laboratory

ERIC Educational Resources Information Center

Ford, Alan R.; Burns, William A.; Reeve, Scott W.

2004-01-01

A version of the classic gas phase infrared experiment was developed for students at Arkansas State University based on the shortcomings of the rotationally resolved infrared experiment. Chem Spec II is a noncommercial Windows-based software package developed to aid in the potentially complicated problem of assigning quantum numbers to observed…

30 CFR 250.806 - Safety and pollution prevention equipment quality assurance requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Gas Operations (as incorporated by reference in § 250.198); and (ii) API Spec Q1, Specification for... in § 250.198). (3) All SSV's and USV's must meet the technical specifications of API Spec 6A and 6AV1. All SSSVs must meet the technical specifications of API Specification 14A (as incorporated by...

30 CFR 250.806 - Safety and pollution prevention equipment quality assurance requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Gas Operations (as incorporated by reference in § 250.198); and (ii) API Spec Q1, Specification for... in § 250.198). (3) All SSV's and USV's must meet the technical specifications of API Spec 6A and 6AV1. All SSSVs must meet the technical specifications of API Specification 14A (as incorporated by...

30 CFR 250.806 - Safety and pollution prevention equipment quality assurance requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Gas Operations (as incorporated by reference in § 250.198); and (ii) API Spec Q1, Specification for... in § 250.198). (3) All SSV's and USV's must meet the technical specifications of API Spec 6A and 6AV1. All SSSVs must meet the technical specifications of API Specification 14A (as incorporated by...

U. S. Naval Forces, Vietnam Monthly Historical Summary for January 1970

DTIC Science & Technology

1970-03-10

T; J. *• i »• hi*?*; iu: ? . •* •-• 7"*" .1 <ZZZcZZ^X^J?^^l^-i?^7^?^ /»round, makes movc-m:nt extremely difficult. Communications vern ...USS KRISHNA (ARL 38) completed a restricted availability at Yokohama and was positioned off Square Bay to support Sea Float operations. The USS...8217.•. -.•’.•.". ’w,’?,"-. r. T -/—’-’r - ) ,. During January repair support was provided to TF-115 Market Time units by the ÜSS TUTUILA (ARG 4), USS KRISHNA (ARL

In vivo determination of root canal length: a preliminary report using the Tri Auto ZX apex-locating handpiece.

PubMed

Grimberg, F; Banegas, G; Chiacchio, L; Zmener, O

2002-07-01

The aim of this study was to assess the clinical perfomance of a cordless handpiece with a built-in apex locator - the Tri Auto ZX - designed for root canal preparation with nickel-titanium rotary files. Twenty-five human maxillary incisor and canine teeth scheduled for extraction with mature apices were selected for the study. Informed written consent was obtained from each patient before treatment. After administration of local anaesthesia, the teeth were isolated and the pulp cavities accessed. The Tri Auto ZX along with a size 15 K-file was used in its electronic apex locating function based on the manufacturer's recommendations. A periapical radiograph with the file at the electronically determined constriction was taken, the file removed and the measurement registered as the electronic length (EL). To test the auto reverse function, a size 20 ProFile.04 taper NiTi rotary instrument was mounted in the handpiece. The point for the auto apical reverse function was preset on the panel at the 0.5 mm level. After the file was introduced into the canal and reached the predetermined level, the file automatically stopped and rotated in the opposite direction. A reference point was marked and this measurement was registered as the auto reverse length (ARL). All measurements were made twice by two different investigators. Teeth were then extracted and immersed in a 20% formalin solution for 48 h. After fixation, a size 15 file was inserted into the canal to measure the actual root canal length from the same reference point obtained with the Tri Auto ZX to the apical foramen, as seen in the stereo microscope. When the file tip was visible at the anatomical end of the canal it was withdrawn 0.5 mm and this measurement was registered as the actual length (AL). All measurements were expressed in mm and the measuring accuracy was set to 0.5 mm. The significance of the mean differences between EL and ARL and between EL and AL measurements at the 5% confidence level was evaluated. EL measurements were coincident to ARL in all instances. EL and ARL were coincident to AL in 10 (40%) canals, in the remaining 15 canals (60%) the AL measurements were longer than EL and ARL (+0.5 mm) in 14 instances and shorter (-0.5 mm) in one case. Overall, the AL was longer than the EL or ARL, the mean difference being -0.23 mm +/- 0.32 (P < 0.05). It was concluded that the Tri Auto ZX was useful and reliable. The Tri Auto ZX measurements protected against overpreparation.

Building Safer Systems With SpecTRM

NASA Technical Reports Server (NTRS)

2003-01-01

System safety, an integral component in software development, often poses a challenge to engineers designing computer-based systems. While the relaxed constraints on software design allow for increased power and flexibility, this flexibility introduces more possibilities for error. As a result, system engineers must identify the design constraints necessary to maintain safety and ensure that the system and software design enforces them. Safeware Engineering Corporation, of Seattle, Washington, provides the information, tools, and techniques to accomplish this task with its Specification Tools and Requirements Methodology (SpecTRM). NASA assisted in developing this engineering toolset by awarding the company several Small Business Innovation Research (SBIR) contracts with Ames Research Center and Langley Research Center. The technology benefits NASA through its applications for Space Station rendezvous and docking. SpecTRM aids system and software engineers in developing specifications for large, complex safety critical systems. The product enables engineers to find errors early in development so that they can be fixed with the lowest cost and impact on the system design. SpecTRM traces both the requirements and design rationale (including safety constraints) throughout the system design and documentation, allowing engineers to build required system properties into the design from the beginning, rather than emphasizing assessment at the end of the development process when changes are limited and costly.System safety, an integral component in software development, often poses a challenge to engineers designing computer-based systems. While the relaxed constraints on software design allow for increased power and flexibility, this flexibility introduces more possibilities for error. As a result, system engineers must identify the design constraints necessary to maintain safety and ensure that the system and software design enforces them. Safeware Engineering Corporation, of Seattle, Washington, provides the information, tools, and techniques to accomplish this task with its Specification Tools and Requirements Methodology (SpecTRM). NASA assisted in developing this engineering toolset by awarding the company several Small Business Innovation Research (SBIR) contracts with Ames Research Center and Langley Research Center. The technology benefits NASA through its applications for Space Station rendezvous and docking. SpecTRM aids system and software engineers in developing specifications for large, complex safety critical systems. The product enables engineers to find errors early in development so that they can be fixed with the lowest cost and impact on the system design. SpecTRM traces both the requirements and design rationale (including safety constraints) throughout the system design and documentation, allowing engineers to build required system properties into the design from the beginning, rather than emphasizing assessment at the end of the development process when changes are limited and costly.

Classification of river water pollution using Hyperion data

NASA Astrophysics Data System (ADS)

Kar, Soumyashree; Rathore, V. S.; Champati ray, P. K.; Sharma, Richa; Swain, S. K.

2016-06-01

A novel attempt is made to use hyperspectral remote sensing to identify the spatial variability of metal pollutants present in river water. It was also attempted to classify the hyperspectral image - Earth Observation-1 (EO-1) Hyperion data of an 8 km stretch of the river Yamuna, near Allahabad city in India depending on its chemical composition. For validating image analysis results, a total of 10 water samples were collected and chemically analyzed using Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES). Two different spectral libraries from field and image data were generated for the 10 sample locations. Advanced per-pixel supervised classifications such as Spectral Angle Mapper (SAM), SAM target finder using BandMax and Support Vector Machine (SVM) were carried out along with the unsupervised clustering procedure - Iterative Self-Organizing Data Analysis Technique (ISODATA). The results were compared and assessed with respect to ground data. Analytical Spectral Devices (ASD), Inc. spectroradiometer, FieldSpec 4 was used to generate the spectra of the water samples which were compiled into a spectral library and used for Spectral Absorption Depth (SAD) analysis. The spectral depth pattern of image and field spectral libraries was found to be highly correlated (correlation coefficient, R2 = 0.99) which validated the image analysis results with respect to the ground data. Further, we carried out a multivariate regression analysis to assess the varying concentrations of metal ions present in water based on the spectral depth of the corresponding absorption feature. Spectral Absorption Depth (SAD) analysis along with metal analysis of field data revealed the order in which the metals affected the river pollution, which was in conformity with the findings of Central Pollution Control Board (CPCB). Therefore, it is concluded that hyperspectral imaging provides opportunity that can be used for satellite based remote monitoring of water quality from space.

A Supplement to the Component Four Implementation Booklet. Broad Goal Definition in Emerald School District. SPECS: School Planning, Evaluation, and Communication System.

ERIC Educational Resources Information Center

Nagle, John M.; Walker, Harold E.

The School Planning, Evaluation, and Communication System (SPECS) is an overall design for districtwide program assessment and development. It is both a way of interrelating planning and evaluation of individual programs and a way of comparing the outcomes of all district programs with the district's community-defined educational goals. This…

Vis- and NIR-based instruments for detection of black-tip damaged wheat kernels: A comparative study

USDA-ARS?s Scientific Manuscript database

Black-tip (BT) present in wheat kernels is a non-mycotoxic fungus that attacks the kernels wherein any of a number of molds forms a dark brown or black sooty mold at the tip of the wheat kernel. Three spectrometers covering the spectral ranges 950-1636nm (Spec1), 600-1045nm (Spec2), and 380-780nm (S...

Micro-Spec: an Integrated, Direct-Detection Spectrometer for Far-Infrared and Sub-Millimeter Astronomy

NASA Astrophysics Data System (ADS)

Cataldo, Giuseppe; Moseley, S. H.; Hsieh, W.; Huang, W.; Stevenson, T.; Wollack, E.

2014-01-01

Many space-based observatories, such as Spitzer and Herschel, have opened the far-infrared (IR) window to the universe, revealing rich line and continuum spectra from objects ranging from interplanetary dust particles to galactic mergers and young galaxies in the early universe. Micro-Spec (µ-Spec) is proposed as a novel technology concept to enable new discoveries in the far-IR spectral range. µ-Spec will be a high-sensitivity, direct-detection spectrometer operating in the 450-1000 µm regime. It will have two antenna arrays, one for transmitting and one for receiving, and superconducting microstrip transmission lines for power division and phase delay. Using superconducting materials reduces losses at a minimum, thereby providing background-limited sensitivity (noise equivalent power, NEP, less than 3x10^-21 W/√Hz) at a resolution 1200, potentially making µ-Spec four orders of magnitude more sensitive than its most capable predecessors. Materials being investigated for the development of the instrument transmission line and detectors include niobium and niobium-titanium nitride for the former, and molybdenum nitride for the latter. In addition, the instrument will be integrated on a four-inch-diameter silicon chip. Such a dramatic size reduction is made possible by the fact that silicon has a refraction index three times that of vacuum, thereby allowing the transmission lines to be shorter than in vacuum by a factor of three. For all these reasons, µ-Spec can become an important capability under the low background conditions provided by space telescopes such as the space infrared telescope for cosmology and astrophysics SPICA, possible Explorers and cryogenically-cooled balloons. The discussion will illustrate a point design developed for initial demonstration with a 30% efficiency due to losses to other diffraction orders. Design variations on this implementation will be shown that lead to near-unity efficiency and will be the basis of future instruments. Models to analyze the properties of the superconductors will also be described along with transmission data used to test and validate the models.

MKS1 regulates ciliary INPP5E levels in Joubert syndrome

PubMed Central

Slaats, Gisela G.; Isabella, Christine R.; Kroes, Hester Y.; Dempsey, Jennifer C.; Gremmels, Hendrik; Monroe, Glen R.; Phelps, Ian G.; Duran, Karen J.; Adkins, Jonathan; Kumar, Sairam A.; Knutzen, Dana M.; Knoers, Nine V.; Mendelsohn, Nancy J.; Neubauer, David; Mastroyianni, Sotiria D.; Vogt, Julie; Worgan, Lisa; Karp, Natalya; Bowdin, Sarah; Glass, Ian A.; Parisi, Melissa A.; Otto, Edgar A.; Johnson, Colin A.; Hildebrandt, Friedhelm; van Haaften, Gijs; Giles, Rachel H.; Doherty, Dan

2016-01-01

Background Joubert syndrome (JS) is a recessive ciliopathy characterized by a distinctive brain malformation “the molar tooth sign”. Mutations in >27 genes cause JS, and mutations in 12 of these genes also cause Meckel syndrome (MKS). The goals of this work are to describe the clinical features of MKS1-related JS and determine whether disease causing MKS1 mutations affect cellular phenotypes such as cilium number, length and protein content as potential mechanisms underlying JS. Methods We measured cilium number, length and protein content (ARL13B and INPP5E) by immunofluorescence in fibroblasts from individuals with MKS1-related JS and in a 3D spheroid rescue assay to test the effects of disease-related MKS1 mutations. Results We report MKS1 mutations (eight of them previously unreported) in nine individuals with JS. A minority of the individuals with MKS1-related JS have MKS features. In contrast to the truncating mutations associated with MKS, all of the individuals with MKS1-related JS carry ≥1 non-truncating mutation. Fibroblasts from individuals with MKS1-related JS make normal or fewer cilia than control fibroblasts, their cilia are more variable in length than controls, and show decreased ciliary ARL13B and INPP5E. Additionally, MKS1 mutant alleles have similar effects in 3D spheroids. Conclusions MKS1 functions in the transition zone at the base of the cilium to regulate ciliary INPP5E content, through an ARL13B-dependent mechanism. Mutations in INPP5E also cause JS, so our findings in patient fibroblasts support the notion that loss of INPP5E function, due to either mutation or mislocalization, is a key mechanism underlying JS, downstream of MKS1 and ARL13B. PMID:26490104

[Genetic polymorphisms of ARL15 and HLA-DMA are associated with rheumatoid arthritis in Han population from northwest China].

PubMed

Wang, Jiao; Qi, Xiaoming; Zhang, Xiaozhen; Yan, Wen; You, Chongge

2017-12-01

Objective To establish the methods for detecting single nucleotide polymorphisms (SNPs) of ADP-ribosylation factor-like GTPase 15 (ARL15), major histocompatibility complex class II-DM alpha (HLA-DMA ) and nuclear factor kappa B subunit 2 (NFKB2) genes using high resolution melting (HRM) technology, and to explore the association of those SNPs with the susceptibility of rheumatoid arthritis (RA) in northwestern Han Chinese population. Methods The PCR-HRM detection system for four SNPs (rs255758, rs1063478, rs397514331 and rs397514332) was established for genotyping, and gene sequencing was performed to validate the genotyping ability of the system. 588 RA cases and 200 controls were enrolled in a case-control study to analyze the associations of ARL15 and HLA-DMA gene polymorphisms with RA risk. Results The direct sequencing validated that the established PCR-HRM detection system could be used for genotyping clinical samples correctly. The mutated genotype of rs397514331 and rs397514332 from NFKB2 gene are not found in this study. The genotype frequencies of rs255758 and rs1063478 had statistical difference between the cases and controls, but no statistical difference in allelic frequencies. Under the dominant model (AA vs AC/CC), the AA genotype of rs255758 decreases the RA risk (OR=0.666, 95%CI=0.478-0.927, P=0.016). Conclusion The method of PCR-HRM we established can be applied to the routine detection of rs255758, rs1063478, rs397514331 and rs397514332. The ARL15 and HLA-DMA gene polymorphisms are associated with RA risk in Northwestern Han Chinese population.

Evaluation of a technology-enhanced integrated care model for frail older persons: protocol of the SPEC study, a stepped-wedge cluster randomized trial in nursing homes.

PubMed

Kim, Hongsoo; Park, Yeon-Hwan; Jung, Young-Il; Choi, Hyoungshim; Lee, Seyune; Kim, Gi-Soo; Yang, Dong-Wook; Paik, Myunghee Cho; Lee, Tae-Jin

2017-04-18

Limited evidence exists on the effectiveness of the chronic care model for people with multimorbidity. This study aims to evaluate the effectiveness of an information and communication technology- (ICT-)enhanced integrated care model, called Systems for Person-centered Elder Care (SPEC), for frail older adults at nursing homes. SPEC is a prospective stepped-wedge cluster randomized trial conducted at 10 nursing homes in South Korea. Residents aged 65 or older meeting the inclusion/exclusion criteria in all the homes are eligible to participate. The multifaceted SPEC intervention, a geriatric care model guided by the chronic care model, consists of five components: comprehensive geriatric assessment for need/risk profiling, individual need-based care planning, interdisciplinary case conferences, person-centered care coordination, and a cloud-based information and communications technology (ICT) tool supporting the intervention process. The primary outcome is quality of care for older residents using a composite measure of quality indicators from the interRAI LTCF assessment system. Outcome assessors and data analysts will be blinded to group assignment. Secondary outcomes include quality of life, healthcare utilization, and cost. Process evaluation will be also conducted. This study is expected to provide important new evidence on the effectiveness, cost-effectiveness, and implementation process of an ICT-supported chronic care model for older persons with multiple chronic illnesses. The SPEC intervention is also unique as the first registered trial implementing an integrated care model using technology to promote person-centered care for frail older nursing home residents in South Korea, where formal LTC was recently introduced. ISRCTN11972147.

[Prevalence of Cardiovascular Risk Factors at The Population Level: A Comparison of Ambulatory Physician-Coded Claims Data With Clinical Data From A Population-Based Study].

PubMed

Angelow, Aniela; Reber, Katrin Christiane; Schmidt, Carsten Oliver; Baumeister, Sebastian Edgar; Chenot, Jean-Francois

2018-06-04

The study assesses the validity of ICD-10 coded cardiovascular risk factors in claims data using gold-standard measurements from a population-based study for arterial hypertension, diabetes, dyslipidemia, smoking and obesity as a reference. Data of 1941 participants (46 % male, mean age 58±13 years) of the Study of Health in Pomerania (SHIP) were linked to electronic medical records from the regional association of statutory health insurance physicians from 2008 to 2012 used for billing purposes. Clinical data from SHIP was used as a gold standard to assess the agreement with claims data for ICD-10 codes I10.- (arterial hypertension), E10.- to E14.- (diabetes mellitus), E78.- (dyslipidemia), F17.- (smoking) and E65.- to E68.- (obesity). A higher agreement between ICD-coded and clinical diagnosis was found for diabetes (sensitivity (sens) 84%, specificity (spec) 95%, positive predictive value (ppv) 80%) and hypertension (sens 72%, spec 93%, ppv 97%) and a low level of agreement for smoking (sens 18%, spec 99%, ppv 89%), obesity (sens 22%, spec 99%, ppv 99%) and dyslipidemia (sens 40%, spec 60%, ppv 70%). Depending on the investigated cardiovascular risk factor, medication, documented additional cardiovascular co-morbidities, age, sex and clinical severity were associated with the ICD-coded cardiovascular risk factor. The quality of ICD-coding in ambulatory care is highly variable for different cardiovascular risk factors and outcomes. Diagnoses were generally undercoded, but those relevant for billing were coded more frequently. Our results can be used to quantify errors in population-based estimates of prevalence based on claims data for the investigated cardiovascular risk factors. © Georg Thieme Verlag KG Stuttgart · New York.

Cooling Effects of Wearer-Controlled Vaporization for Extravehicular Activity.

PubMed

Tanaka, Kunihiko; Nagao, Daiki; Okada, Kosuke; Nakamura, Koji

2017-04-01

The extravehicular activity suit currently used by the United States in space includes a liquid cooling and ventilation garment (LCVG) that controls thermal conditions. Previously, we demonstrated that self-perspiration for evaporative cooling (SPEC) garment effectively lowers skin temperature without raising humidity in the garment. However, the cooling effect is delayed until a sufficient dose of water permeates and evaporates. In the present study, we hypothesized that wearer-controlled vaporization improves the cooling effect. Six healthy subjects rode a cycle ergometer under loads of 30, 60, 90, and 120 W for durations of 3 min each. Skin temperature and humidity on the back were measured continuously. Subjects wore and tested three garments: 1) a spandex garment without any cooling device (Normal); 2) a simulated LCVG (s-LCVG) or spandex garment knitted with a vinyl tube for flowing and permeating water; and 3) a garment that allowed wearer-controlled vaporization (SPEC-W). The use of s-LCVG reduced skin temperature by 1.57 ± 0.14°C during 12 min of cooling. Wearer-controlled vaporization of the SPEC-W effectively and significantly lowered skin temperature from the start to the end of cycle exercise. This decrease was significantly larger than that achieved using s-LCVG. Humidity in the SPEC-W was significantly lower than that in s-LCVG. This preliminary study suggests that SPEC-W is effective in lowering skin temperature without raising humidity in the garment. The authors think it would be useful in improving the design of a cooling system for extravehicular activity.Tanaka K, Nagao D, Okada K, Nakamura K. Cooling effects of wearer-controlled vaporization for extravehicular activity. Aerosp Med Hum Perform. 2017; 88(4):418-422.

Prevalence of increased canine pancreas-specific lipase concentrations in young dogs with parvovirus enteritis.

PubMed

Kalli, Irida V; Adamama-Moraitou, Katerina K; Patsika, Michael N; Pardali, Dimitra; Steiner, Jörg M; Suchodolski, Jan S; Menexes, George; Brellou, Georgia D; Rallis, Timoleon S

2017-03-01

Pancreatic abnormalities during canine parvovirus (CPV) enteritis have not been studied prospectively. The objective of this study was to evaluate the diagnostic significance of canine serum pancreas-specific lipase (Spec cPL) concentration in dogs with CPV enteritis for the presence of acute pancreatitis (AP). Puppies with naturally occurring CPV enteritis were recruited and prospectively allocated into 2 groups according to normal or increased serum Spec cPL concentration. Clinical signs, laboratory findings, and pancreas-associated variables were compared between groups, and the impact of possible AP on disease course, duration of hospitalization, and outcome was assessed. Serum Spec cPL concentration in 35 puppies was above the upper limit of the RI in 17/35 (48.6%) dogs (Group A) and within the RI in 18 dogs (Group B). An increased serum lipase activity was present in 29/35 (82.9%) dogs, and Group A dogs had a higher serum lipase activity than Group B (P = .006). Serum Spec cPL in Group A dogs was positively correlated with serum lipase activity at the day of presentation (r = .667; P = .003) and day of discharge (r = .628; P = .007). No statistically significant difference was found between groups (P = .233) for the presence of systemic inflammatory response syndrome (SIRS) (6/17 or 35.3% dogs Group A, and 8/18 or 44.4% dogs Group B), the disease course, duration of hospitalization, or outcome between groups. Increased serum Spec cPL is relatively common in dogs with CPV enteritis. However, such increases do not seem to correlate with the outcome of disease. © 2017 American Society for Veterinary Clinical Pathology.

An Airborne Infrared Spectrometer for Solar Eclipse Observations

NASA Astrophysics Data System (ADS)

Samra, Jenna; DeLuca, Edward E.; Golub, Leon; Cheimets, Peter; Philip, Judge

2016-05-01

The airborne infrared spectrometer (AIR-Spec) is an innovative solar spectrometer that will observe the 2017 solar eclipse from the NSF/NCAR High-Performance Instrumented Airborne Platform for Environmental Research (HIAPER). AIR-Spec will image five infrared coronal emission lines to determine whether they may be useful probes of coronal magnetism.The solar magnetic field provides the free energy that controls coronal heating, structure, and dynamics. Energy stored in coronal magnetic fields is released in flares and coronal mass ejections and ultimately drives space weather. Therefore, direct coronal field measurements have significant potential to enhance understanding of coronal dynamics and improve solar forecasting models. Of particular interest are observations of field lines in the transitional region between closed and open flux systems, providing important information on the origin of the slow solar wind.While current instruments routinely observe only the photospheric and chromospheric magnetic fields, AIR-Spec will take a step toward the direct observation of coronal fields by measuring plasma emission in the infrared at high spatial and spectral resolution. During the total solar eclipse of 2017, AIR-Spec will observe five magnetically sensitive coronal emission lines between 1.4 and 4 µm from the HIAPER Gulfstream V at an altitude above 14.9 km. The instrument will measure emission line intensity, width, and Doppler shift, map the spatial distribution of infrared emitting plasma, and search for waves in the emission line velocities.AIR-Spec consists of an optical system (feed telescope, grating spectrometer, and infrared detector) and an image stabilization system, which uses a fast steering mirror to correct the line-of-sight for platform perturbations. To ensure that the instrument meets its research goals, both systems are undergoing extensive performance modeling and testing. These results are shown with reference to the science requirements.

Millimeter-wave Spectroscopy of NGC1068 With Z-Spec

NASA Astrophysics Data System (ADS)

Kamenetzky, Julia; Aguirre, J. E.; Bock, J. J.; Bradford, M.; Earle, L.; Glenn, J.; Maloney, P.; Matsuhara, H.; Naylor, B.; Nguyen, H. T.; Zmuidzinas, J.

2009-05-01

NGC1068 is commonly cited as the prototypical Seyfert 2 galaxy. Both the central and extended regions have been studied extensively across the electromagnetic spectrum, revealing many different astrophysical phenomena, such as a bright central region, radio jet knots, and a conical narrow-line region. Significantly, evidence has been found that the active galactic nucleus is shrouded by a dusty molecular disk, which could support the theory that viewing angle will unify Seyfert 1 and 2 galaxies. We observed NGC1068 with Z-Spec, a broadband (185-305 GHz) millimeter-wave grating spectrometer, at the Caltech Submillimeter Observatory. Its large bandwidth allows us to simultaneously observe multiple molecular rotational transitions along with the underlying continuum. The detector array is composed of 160 silicon-nitride micromesh bolometers cooled to 60 mK by an adiabatic demagnetization refrigerator (ADR) and a closed-cycle 3He refrigerator. Z-Spec's compact design is achieved via a WaFIRS (Waveguide Far IR Spectrometer) design utilizing a parallel-plate waveguide and curved diffraction grating. Z-Spec's spectral resolution is approximately 900 MHz at the band center. We obtained a high signal-to-noise ratio spectrum of NGC1068 in late January 2007. Key observable transitions in Z-Spec's bandpass include CO , 13CO, and C18O (J = 2 - 1), HCN, HNC, and HCO+ (J = 3 - 2), and multiple CS transitions. We are modeling the NGC1068 spectrum using these data and other transitions of these molecules from the literature to probe the physical characteristics of its interstellar medium, such as temperature, density, dense gas fraction, and the extent of the AGN's contribution to the molecular gas excitation. We will present preliminary results of the analysis.

ASPIRE - Airborne Spectro-Polarization InfraRed Experiment

NASA Astrophysics Data System (ADS)

DeLuca, E.; Cheimets, P.; Golub, L.; Madsen, C. A.; Marquez, V.; Bryans, P.; Judge, P. G.; Lussier, L.; McIntosh, S. W.; Tomczyk, S.

2017-12-01

Direct measurements of coronal magnetic fields are critical for taking the next step in active region and solar wind modeling and for building the next generation of physics-based space-weather models. We are proposing a new airborne instrument to make these key observations. Building on the successful Airborne InfraRed Spectrograph (AIR-Spec) experiment for the 2017 eclipse, we will design and build a spectro-polarimeter to measure coronal magnetic field during the 2019 South Pacific eclipse. The new instrument will use the AIR-Spec optical bench and the proven pointing, tracking, and stabilization optics. A new cryogenic spectro-polarimeter will be built focusing on the strongest emission lines observed during the eclipse. The AIR-Spec IR camera, slit jaw camera and data acquisition system will all be reused. The poster will outline the optical design and the science goals for ASPIRE.

Ada Compiler Validation Summary Report: Certificate Number: 890804S1. 10142 Loral/Rolm Mil-Spec Computers ADE, Revision 3.01 MV 10000 Host and HAWK/32 Target

DTIC Science & Technology

1989-08-04

Date Owners Declaration I, the undersigned, representing agree that as part of the joint Marketing Agreement between Roim Mil-Spec and Data General for...possible. Format pragma NLINE (name (, namei): Where: name Specfies the subprogram or neric unit you want inLined at each calL The subprogam or

Ada Compiler Validation Summary Report: Certificate Number: 890804S1.10141 Loral/Rolm Mil-Spec Computers ADE, Revision 3.01 MV 10000 Host and HAWK/32 Target

DTIC Science & Technology

1989-08-04

undersigned, representing /-- /Wz agree that as part of the joint Marketing Agreement between Rolm Mil-Spec and Data General for the Ada Development...the assembly (e wkhout the pragma. Source Code in the folowing emaple, prama NLINE applie to all tb calls to SQUARE in WrrH INLINF. procedure WITH

SpecOMS: A Full Open Modification Search Method Performing All-to-All Spectra Comparisons within Minutes.

PubMed

David, Matthieu; Fertin, Guillaume; Rogniaux, Hélène; Tessier, Dominique

2017-08-04

The analysis of discovery proteomics experiments relies on algorithms that identify peptides from their tandem mass spectra. The almost exhaustive interpretation of these spectra remains an unresolved issue. At present, an important number of missing interpretations is probably due to peptides displaying post-translational modifications and variants that yield spectra that are particularly difficult to interpret. However, the emergence of a new generation of mass spectrometers that provide high fragment ion accuracy has paved the way for more efficient algorithms. We present a new software, SpecOMS, that can handle the computational complexity of pairwise comparisons of spectra in the context of large volumes. SpecOMS can compare a whole set of experimental spectra generated by a discovery proteomics experiment to a whole set of theoretical spectra deduced from a protein database in a few minutes on a standard workstation. SpecOMS can ingeniously exploit those capabilities to improve the peptide identification process, allowing strong competition between all possible peptides for spectrum interpretation. Remarkably, this software resolves the drawbacks (i.e., efficiency problems and decreased sensitivity) that usually accompany open modification searches. We highlight this promising approach using results obtained from the analysis of a public human data set downloaded from the PRIDE (PRoteomics IDEntification) database.

ARL2BP, a protein linked to Retinitis Pigmentosa, is needed for normal photoreceptor cilia doublets and outer segment structure.

PubMed

Moye, Abigail R; Singh, Ratnesh; Kimler, Victoria A; Dilan, Tanya L; Munezero, Daniella; Saravanan, Thamaraiselvi; Goldberg, Andrew F X; Ramamurthy, Visvanathan

2018-05-02

The outer segment (OS) of photoreceptor cells is an elaboration of a primary cilium with organized stacks of membranous discs that contain the proteins needed for phototransduction and vision. Though cilia formation and function has been well characterized, little is known about the role of cilia in the development of photoreceptor OS. Nevertheless, progress has been made by studying mutations in ciliary proteins which often result in malformed outer segments and lead to blinding diseases. To investigate how ciliary proteins contribute to outer segment formation, we generated a knockout mouse model for ARL2BP, a ciliary protein linked to Retinitis Pigmentosa. The knockout mice display an early and progressive reduction in visual response. Prior to photoreceptor degeneration we observed disorganization of the photoreceptor OS, with vertically aligned discs and shortened axonemes. Interestingly, ciliary doublet microtubule structure was also impaired, displaying open B-tubule doublets, paired with loss of singlet microtubules. Based on results from this study, we conclude that ARL2BP is necessary for photoreceptor cilia doublet formation and axoneme elongation, which is required for outer segment morphogenesis and vision.

Genetical approach to gravitropism

NASA Astrophysics Data System (ADS)

Boonsirichai, K.; Chen, R.; Guan, C.; Rosen, E.; Young, L.; Masson, P.

Gravitropism guides the growth of plant organs at a defined angle from the gravity vector. Accordingly, most roots grow downward, undergoing positive gravitropism. Gravity perception by roots appears to involve the sedimentation of amyloplasts within the columella cells of the cap. Amyloplast sedimentation triggers a signal transduction pathway that promotes the development of an auxin gradient across the root tip. This gradient is then transmitted to the elongation zones where it promotes a differential cellular elongation, partly responsible for the development of a root-tip curvature. To better understand the mechanisms involved in gravity signal transduction, we have identified and characterized several Arabidopsis thaliana mutants that show specific defects in root gravitropism. Several of these genes were characterized. ARG1 functions in gravity signal transduction, and encodes a dnaJ-like protein whose structure suggests an interaction with the cytoskeleton. Two other genes encode similar proteins (ARL1 and ARL2) in Arabidopsis. One of them (ARL2) also appears to function in gravity signal transduction. Because loss-of-function mutations in ARG1 result in partial alterations of gravitropism, we were able to identify and characterize two genetic enhancers of arg1-2: mar1-1 and mar2-1. These enhancers increased the gravitropism defect of arg1-2 roots and hypocotyls, and changed its orientation. Hence, MAR1 and MAR2 also appear to function in gravity signal transduction. AGR1, on the other hand, encodes a transmembrane component of the auxin efflux carrier complex involved in polar auxin transport through the elongation zones of Arabidopsis root tips. It belongs to a large gene family, several members of which are expressed in the root cap. Upon gravistimulation, the AGR3 protein appears to quickly relocate within the columella cells, accumulating in membranes at the new physical bottom. Hence, the gravity signal transduction pathway that includes the ARG1, ARL2, MAR1 and MAR2 gene products, appears to control the cellular distribution of auxin efflux carriers in the columella cells of the root cap, thereby controlling the polarity of lateral auxin transport in response to gravistimulation. Work is in progress to identify new proteins that interact genetically or physically with ARG1, ARL2 or AGR1, and characterize their involvement in gravitropism.

Spec Rekindled-A Simple Torque Correction Mechanics for Transposed Teeth in Conjunction with Pre-adjusted Edgewise Appliance System.

PubMed

Singh, Harpreet; Maurya, Raj Kumar; Thakkar, Surbhi

2016-12-01

Complete transposition of teeth is a rather rare phenomenon. After correction of transposed and malaligned lateral incisor and canine, attainment of appropriate individual antagonistic tooth torque is indispensable, which many orthodontists consider to be a herculean task. Here, a novel method is proposed which demonstrates the use of Spec reverse torquing auxillary as an effective adjunctive aid in conjunction with pre-adjusted edgewise brackets.

The potential pyrophoricity of BMI-SPEC and aluminum plate spent fuels retrieved from underwater storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebner, M.A.

1996-08-01

Physical/chemical factors in U metal and hydride combustion, particularly pyrophoricity in ambient environment, were evaluated for BMI-SPEC and UAl{sub x} plate fuels. Some metal fuels may be highly reactive (spontaneously igniting in air) due to high specific surface area, high decay heat, or a high U hydride content from corrosion during underwater storage. However, for the BMI-SPEC and the aluminum plate fuels, this reactivity is too low to present a realistic threat of uncontrolled spontaneous combustion at ambient conditions. While residual U hydride is expected in these corroded fuels, the hydride levels are expected to be too low and themore » configuration too unfavorable to ignite the fuel meat when the fuels are retrieved from the basin and dried. Furthermore the composition and microstructure of the UAl{sub x} fuels further mitigate that risk.« less

Detection and differentiation of biological species using microcalorimetric spectroscopy.

PubMed

Arakawa, E T; Lavrik, N V; Rajic, S; Datskos, P G

2003-01-01

We report on the application of infrared (IR) microcalorimetric spectroscopy ( micro -CalSpec) to the identification and detection of trace amounts of biological species. Our approach combines principles of photothermal IR spectroscopy with ultrasensitive microcantilever (MC) thermal detectors. We have obtained photothermal IR spectra for DNA and RNA bases and for Bacillus Cereus (an anthrax simulant) in the wavelength range of 2.5-14.5 micro m (4000-690 cm(-1)). The measurements are accomplished by absorbing biological materials directly on a MC thermal detector. The main advantage of the developed micro -CalSpec is its unprecedented sensitivity as compared to any of the previously explored IR techniques, including FTIR and photothermal FTIR methods. Our results demonstrate that <10(-9)g of a biological sample is sufficient to obtain its characteristic micro -CalSpec spectrum that contains information-rich chemical (vibrational) signatures. This opens up a new opportunity to create inexpensive high-throughput analytical systems for biochemical detection.

Improving the accuracy of synovial fluid analysis in the diagnosis of prosthetic joint infection with simple and inexpensive biomarkers: C-reactive protein and adenosine deaminase.

PubMed

Sousa, R; Serrano, P; Gomes Dias, J; Oliveira, J C; Oliveira, A

2017-03-01

The aims of this study were to increase the diagnostic accuracy of the analysis of synovial fluid in the differentiation of prosthetic joint infection (PJI) by the addition of inexpensive biomarkers such as the levels of C-reactive protein (CRP), adenosine deaminase (ADA), alpha-2-macrogloblulin (α2M) and procalcitonin. Between January 2013 and December 2015, synovial fluid and removed implants were requested from 143 revision total joint arthroplasties. A total of 55 patients met inclusion criteria of the receipt of sufficient synovial fluid, tissue samples and removed implants for analysis. The diagnosis of PJI followed the definition from a recent International Consensus Meeting to create two groups of patients; septic and aseptic. Using receiver operating characteristic curves we determined the cutoff values and diagnostic accuracy for each marker. There were 23 PJIs and 32 patients with aseptic loosening. The levels of total leucocyte count, proportion of polymorphonuclear leucocytes (PMNs), CRP, ADA and α2M in the synovial fluid were all significantly higher in those with a PJI than in those with aseptic loosening. The levels of procalcitonin were comparable in the two groups. Cutoff values for the optimal performance in the diagnosis of infection were: total leucocyte count > 1463 cells/μL (sensitivity (Sens) 100%, specificity (Spec) 71.9%, positive predictive value (PPV) 71.9%, negative predictive value (NPV) 100%); proportion of PMNs > 81% (Sens 78.3%, Spec 75.0%, PPV 69.2%, NPV 82.8%); CRP > 6.7mg/L (Sens 78.3%, Spec 93.8%, PPV 90.0%, NPV 85.7%); ADA > 61U/L (Sens 78.3%, Spec 96.9%, PPV 94.7%, NPV 86.1%) and α2M > 958 mg/L (Sens 47.8%, Spec 96.9%, PPV 91.7%, NPV 72.1%). The addition of a raised level of CRP or ADA to the total leukocyte count increased the specificity: total leukocyte count > 1463 cells/μL and CRP > 6.7mg/L (Sens 78.3%, Spec 100%, PPV 100%, NPV 86.5%) or with ADA > 61U/L (Sens 78.3%, Spec 96.9%, PPV 94.7%, NPV 86.1%). The total leucocyte count in the synovial fluid offers great negative predictive value in the diagnosis of PJI and the addition of more specific markers such as CRP and ADA improves the positive predictive value. Thus the addition of simple and inexpensive markers to the measurement of the leucocyte count in the synovial fluid may reduce the number of equivocal results which demand more expensive investigation. Cite this article: Bone Joint J 2017;99-B:351-7. ©2017 The British Editorial Society of Bone & Joint Surgery.

Spectrophotometric calibration procedures to enable calibration-free measurements of seawater calcium carbonate saturation states.

PubMed

Cuyler, Erin E; Byrne, Robert H

2018-08-22

A simple protocol was developed to measure seawater calcium carbonate saturation states (Ω spec ) spectrophotometrically. Saturation states are typically derived from the separate measurement of two other carbon system parameters, with each requiring unique instrumentation and often complex measurement protocols. Using the new protocol, the only required equipment is a thermostatted laboratory spectrophotometer. For each seawater sample, spectrophotometric measurements of pH (visible absorbance) are made in paired optical cells, one with and one without added nitric acid. Ultraviolet absorbance is measured to determine the amount of added acid based on the direct proportionality between nitrate concentration and UV absorbance. Coupled measurements of pH and the alkalinity change that accompanies the nitric acid addition allow calculation of a seawater sample's original carbonate ion concentration and saturation state. These paired absorbance measurements yield Ω spec (and other carbonate system parameters), with each sample requiring about 12 min processing time. Initially, an instrument-specific nitrate molar absorptivity coefficient must be determined (due to small but significant discrepancies in instrumental wavelength calibrations), but thereafter no further calibration is needed. In this work, the 1σ precision of replicate measurements of aragonite saturation state was found to be 0.020, and the average difference between Ω spec and Ω calculated conventionally from measured total alkalinity and pH (Ω calc ) was -0.11% ± 0.96% (a level of accuracy comparable to that obtained from spectrophotometric measurements of carbonate ion concentration). Over the entire range of experimental conditions, 0.97 < Ω < 3.17 (n = 125), all measurements attained the Global Ocean Acidification Observing Network's "weather level" goal for accuracy and 90% attained the more stringent "climate level" goal. When Ω spec was calculated from averages of duplicate samples (n = 56), the precision improved to 0.014 and the average difference between Ω spec and Ω calc improved to -0.11% ± 0.73%. Additionally, 97% of the duplicate-based Ω spec measurements attained the "climate level" accuracy goal. These results indicate that the simple measurement protocol developed in this work should be widely applicable for monitoring fundamental seawater changes associated with ocean acidification. Copyright © 2018 Elsevier B.V. All rights reserved.

Peak broadening and peak shift pole figures investigations by STRESS-SPEC diffractometer at FRM II

NASA Astrophysics Data System (ADS)

Gan, W. M.; Randau, C.; Hofmann, M.; Brokmeier, H. G.; Mueller, M.; Schreyer, A.

2012-02-01

This paper studied for the first time peak intensity, peak position and FHWM pole figures with one time measurement at the neutron diffractometer STRESS-SPEC via in-situ tensile deformation on austenitic steel. Fibre distribution with its evolution from central tensile direction to normal direction of these three kinds of pole figures was obtained. Variation of peak position and FWHM can be correlated to the reorientation of the texture component.

Spec Rekindled-A Simple Torque Correction Mechanics for Transposed Teeth in Conjunction with Pre-adjusted Edgewise Appliance System

PubMed Central

Singh, Harpreet; Thakkar, Surbhi

2016-01-01

Complete transposition of teeth is a rather rare phenomenon. After correction of transposed and malaligned lateral incisor and canine, attainment of appropriate individual antagonistic tooth torque is indispensable, which many orthodontists consider to be a herculean task. Here, a novel method is proposed which demonstrates the use of Spec reverse torquing auxillary as an effective adjunctive aid in conjunction with pre-adjusted edgewise brackets. PMID:28209017

Revision of the genus Devadatta Kirby, 1890 in Borneo based on molecular and morphological methods, with descriptions of four new species (Odonata: Zygoptera: Devadattidae).

PubMed

Dow, Rory A; Hämäläinen, Matti; Stokvis, Frank R

2015-10-23

Species of Devadatta from Borneo are studied using both morphological and molecular methods. As well as D. podolestoides Laidlaw, four new species are recognised from the island: D. aran spec. nov. (holotype ♂, from Pulong Tau National Park, Miri division, Sarawak, Malaysia, deposited in RMNH), D. clavicauda spec. nov. (holotype ♂, from Bukit Mina, Bukit Mina Wildlife Corridor, Sarawak Planted Forest Project, Bintulu division, Sarawak, Malaysia, deposited in RMNH), D. somoh spec. nov. (holotype ♂, from the Sungai Kahei area, Ulu Balui, Kapit division, Sarawak, Malaysia, deposited in RMNH) and D. tanduk spec. nov. (holotype ♂, from Poring Hot Springs, Kinabalu National Park, West Coast division, Sabah, Malaysia, deposited in RMNH). The Philippine taxon D. basilanensis Laidlaw is considered a good species rather than a subspecies of D. podolestoides. The Bornean species plus D. basilanensis are provisionally considered to form a species group, the podolestoides-group, within Devadatta. The species of the podolestoides-group are so similar in morphology and colouration that they are close to truly cryptic species. Two species appear to exhibit character displacement where their ranges overlap with other Devadatta species. A molecular analysis using four markers (COI, 16S, ITS and 28S) is presented. This analysis includes specimens of all species from the podolestoides-group and two Devadatta species from mainland Asia.

SpecPad: device-independent NMR data visualization and processing based on the novel DART programming language and Html5 Web technology.

PubMed

Guigas, Bruno

2017-09-01

SpecPad is a new device-independent software program for the visualization and processing of one-dimensional and two-dimensional nuclear magnetic resonance (NMR) time domain (FID) and frequency domain (spectrum) data. It is the result of a project to investigate whether the novel programming language DART, in combination with Html5 Web technology, forms a suitable base to write an NMR data evaluation software which runs on modern computing devices such as Android, iOS, and Windows tablets as well as on Windows, Linux, and Mac OS X desktop PCs and notebooks. Another topic of interest is whether this technique also effectively supports the required sophisticated graphical and computational algorithms. SpecPad is device-independent because DART's compiled executable code is JavaScript and can, therefore, be run by the browsers of PCs and tablets. Because of Html5 browser cache technology, SpecPad may be operated off-line. Network access is only required during data import or export, e.g. via a Cloud service, or for software updates. A professional and easy to use graphical user interface consistent across all hardware platforms supports touch screen features on mobile devices for zooming and panning and for NMR-related interactive operations such as phasing, integration, peak picking, or atom assignment. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Separation of parallel encoded complex-valued slices (SPECS) from a single complex-valued aliased coil image.

PubMed

Rowe, Daniel B; Bruce, Iain P; Nencka, Andrew S; Hyde, James S; Kociuba, Mary C

2016-04-01

Achieving a reduction in scan time with minimal inter-slice signal leakage is one of the significant obstacles in parallel MR imaging. In fMRI, multiband-imaging techniques accelerate data acquisition by simultaneously magnetizing the spatial frequency spectrum of multiple slices. The SPECS model eliminates the consequential inter-slice signal leakage from the slice unaliasing, while maintaining an optimal reduction in scan time and activation statistics in fMRI studies. When the combined k-space array is inverse Fourier reconstructed, the resulting aliased image is separated into the un-aliased slices through a least squares estimator. Without the additional spatial information from a phased array of receiver coils, slice separation in SPECS is accomplished with acquired aliased images in shifted FOV aliasing pattern, and a bootstrapping approach of incorporating reference calibration images in an orthogonal Hadamard pattern. The aliased slices are effectively separated with minimal expense to the spatial and temporal resolution. Functional activation is observed in the motor cortex, as the number of aliased slices is increased, in a bilateral finger tapping fMRI experiment. The SPECS model incorporates calibration reference images together with coefficients of orthogonal polynomials into an un-aliasing estimator to achieve separated images, with virtually no residual artifacts and functional activation detection in separated images. Copyright © 2015 Elsevier Inc. All rights reserved.