The Nature of Computer Assisted Learning.

ERIC Educational Resources Information Center

Whiting, John

Computer assisted learning (CAL) is an old technology which has generated much new interest. Computers can: reduce data to a directly comprehensible form; reduce administration; communicate worldwide and exchange, store, and retrieve data; and teach. The computer's limitation is in its dependence on the user's ability and perceptive nature.…

Audio-Enhanced Computer Assisted Learning and Computer Controlled Audio-Instruction.

ERIC Educational Resources Information Center

Miller, K.; And Others

1983-01-01

Describes aspects of use of a microcomputer linked with a cassette recorder as a peripheral to enhance computer-assisted learning (CAL) and a microcomputer-controlled tape recorder linked with a microfiche reader in a commercially available teaching system. References and a listing of control programs are appended. (EJS)

Comparison of traditional and interactive teaching methods in a UK emergency department.

PubMed

Armstrong, Peter; Elliott, Tim; Ronald, Julie; Paterson, Brodie

2009-12-01

Didactic teaching remains a core component of undergraduate education, but developing computer assisted learning (CAL) packages may provide useful alternatives. We compared the effectiveness of interactive multimedia-based tutorials with traditional, lecture-based models for teaching arterial blood gas interpretation to fourth year medical students. Participants were randomized to complete a tutorial in either lecture or multimedia format containing identical content. Upon completion, students answered five multiple choice questions assessing post-tutorial knowledge, and provided feedback on their allocated learning method. Marks revealed no significant difference between either group. All lecture candidates rated their teaching as good, compared with 89% of the CAL group. All CAL users found multiple choice questions assessment useful, compared with 83% of lecture participants. Both groups highlighted the importance of interaction. CAL complements other teaching methods, but should be seen as an adjunct to, rather than a replacement for, traditional methods, thus offering students a blended learning environment.

German dental faculty attitudes towards computer-assisted learning and their correlation with personal and professional profiles.

PubMed

Welk, A; Rosin, M; Seyer, D; Splieth, C; Siemer, M; Meyer, G

2005-08-01

Compared with its potential, computer technology use is still lacking in medical/dental education. To investigate the primary advantages of computer-assisted learning (CAL) systems in German dental education, as well as the reasons for their relatively low degree of use correlated with personal and professional profiles of respondents. A questionnaire was mailed to heads in the departments of conservative dentistry and prosthetic dentistry in all dental schools in Germany. Besides investigating the advantages and barriers to the use of computer technology, the questionnaire also contained questions regarding each respondent's gender, age, academic rank, experience in academia and computer skills. The response rate to the questionnaire was 90% (112 of 125). The results indicated a distinct discrepancy between the desire for and actual occurrence of lectures, seminars, etc. to instruct students in ways to search for and acquire knowledge, especially using computer technology. The highest-ranked advantages of CAL systems in order, as seen by respondents, were the possibilities for individual learning, increased motivation, and both objective theoretical tests and practical tests. The highest-ranked reasons for the low degree of usage of CAL systems in order were the inability to finance, followed equally by a lack of studies of CAL and poor cost-advantage ratio, and too much effort required to integrate CAL into the curriculum. Moreover, the higher the computer skills of the respondents, the more they noted insufficient quality of CAL systems (r = 0.200, P = 0.035) and content differences from their own dental faculty's expert opinions (r = 0.228, P = 0.016) as reasons for low use. The correlations of the attitudes towards CAL with the personal and professional profiles showed not only statistical significant reinforcements of, but also interesting deviations from, the average responses.

Teachers' Perceptions on the Use of ICT in a CAL Environment to Enhance the Conception of Science Concepts

ERIC Educational Resources Information Center

George, Frikkie; Ogunniyi, M.

2016-01-01

Instructional methodologies increasingly require teachers' efficacy and implementation of computer-assisted learning (CAL) practices in general and particularly in the science classroom. The South African National Education Department's e-Education[1] policy also encourages the use of computers and computer software in implementing outcome-based…

The use of computer assisted technology to enhance student psychiatric nurses learning during a practice placement.

PubMed

Denny, Margaret; Higgins, Agnes

2003-06-01

Despite the available literature that identifies the value of integrating computer-assisted learning into the curriculum, psychiatric nurse education lags behind in this area of curriculum development. The purpose of this paper is to report on a pilot project involving the use of a computer assisted learning (CAL) interactive multimedia (IMM) package called 'Admissions,' as a self-directed learning tool with two-second year psychiatric nursing students. The students were on a practice placement in an Irish mental health service. The aim of using the multimedia resource was to augment the students' learning during their practice placement and enable them to re-examine the issue of psychosis from a multiplicity of perspectives. This paper provides a brief description of the interactive multimedia package, together with a discussion on the support offered to the students during its use. experiential taxonomy is used as a framework to guide the discussion on the learning and evaluation process used. Feedback from the students suggests that the CAL package is easy to use, informative and promoted independence and self-directed study.

Courseware Development with Animated Pedagogical Agents in Learning System to Improve Learning Motivation

ERIC Educational Resources Information Center

Chin, Kai-Yi; Hong, Zeng-Wei; Huang, Yueh-Min; Shen, Wei-Wei; Lin, Jim-Min

2016-01-01

The addition of animated pedagogical agents (APAs) in computer-assisted learning (CAL) systems could successfully enhance students' learning motivation and engagement in learning activities. Conventionally, the APA incorporated multimedia materials are constructed through the cooperation of teachers and software programmers. However, the thinking…

Measuring the Effectiveness of Blended Learning Environment: A Case Study in Malaysia

ERIC Educational Resources Information Center

Wai, Cho Cho; Seng, Ernest Lim Kok

2015-01-01

Learning environment has always been traditionally associated with the physical presence of classrooms, textbooks, pen-and-paper examinations and teachers. However, today's evolving technology has rapidly changed the face of education. Online learning, teleconferencing, internet, Computer Assisted Learning (CAL), Web-Based Distance Learning (WBDL)…

The Essen Learning Model--A Step towards a Representation of Learning Objectives.

ERIC Educational Resources Information Center

Bick, Markus; Pawlowski, Jan M.; Veith, Patrick

The importance of the Extensible Markup Language (XML) technology family in the field of Computer Assisted Learning (CAL) can not be denied. The Instructional Management Systems Project (IMS), for example, provides a learning resource XML binding specification. Considering this specification and other implementations using XML to represent…

Keewatin Region Educational Authority Pilot Education Project: Computer-Assisted Learning. Preliminary Final Report.

ERIC Educational Resources Information Center

Wolter, Heidi; And Others

A project was conducted to improve and expand academic upgrading, job readiness, and special skill training for adults in the Keewatin Region through the implementation of computer-assisted learning (CAL). It was intended as a response to the special needs of unemployed Inuit who were not reached in the past by traditional training programs and…

Using CAD Programs in CAL.

ERIC Educational Resources Information Center

Boardman, D.

1979-01-01

Practical experience has shown that computer aided design programs can provide an invaluable aid in the learning process when integrated into the syllabus in lecture and laboratory periods. This should be a major area of future development of computer assisted learning in engineering education. (Author/CMV)

Computer Based Learning in Europe: A Bibliography.

ERIC Educational Resources Information Center

Rushby, N. J.

This bibliography lists 172 references to papers on computer assisted learning (CAL) in European countries including the Soviet Union, Germany, Holland, Sweden, Yugoslavia, Austria, and Italy. The references which deal with such topics as teacher training, simulation, rural education, model construction, program evaluation, computer managed…

A remote sensing computer-assisted learning tool developed using the unified modeling language

NASA Astrophysics Data System (ADS)

Friedrich, J.; Karslioglu, M. O.

The goal of this work has been to create an easy-to-use and simple-to-make learning tool for remote sensing at an introductory level. Many students struggle to comprehend what seems to be a very basic knowledge of digital images, image processing and image arithmetic, for example. Because professional programs are generally too complex and overwhelming for beginners and often not tailored to the specific needs of a course regarding functionality, a computer-assisted learning (CAL) program was developed based on the unified modeling language (UML), the present standard for object-oriented (OO) system development. A major advantage of this approach is an easier transition from modeling to coding of such an application, if modern UML tools are being used. After introducing the constructed UML model, its implementation is briefly described followed by a series of learning exercises. They illustrate how the resulting CAL tool supports students taking an introductory course in remote sensing at the author's institution.

Comparison of a computer assisted learning program to standard education tools in hospitalized heart failure patients.

PubMed

Dilles, Ann; Heymans, Valerie; Martin, Sandra; Droogné, Walter; Denhaerynck, Kris; De Geest, Sabina

2011-09-01

Education, coaching and guidance of patients are important components of heart failure management. The aim of this study was to compare a computer assisted learning (CAL) program with standard education (brochures and oral information from nurses) on knowledge and self-care in hospitalized heart failure patients. Satisfaction with the CAL program was also assessed in the intervention group. A quasi-experimental design was used, with a convenience sample of in-hospital heart failure patients. Knowledge and self-care were measured using the Dutch Heart Failure Knowledge Scale and the European Heart Failure Self-care Behaviour Scale at hospital admission, at discharge and after a 3-month follow-up. Satisfaction with the CAL program was assessed at hospital discharge using a satisfaction questionnaire. Within and between groups, changes in knowledge and self-care over time were tested using a mixed regression model. Of 65 heart failure patients screened, 37 were included in the study: 21 in the CAL group and 16 in the usual care group. No significant differences in knowledge (p=0.65) or self-care (p=0.40) could be found between groups. However, both variables improved significantly over time in each study group (p<0.0001). Both educational strategies increased knowledge and improved self-care. The design did not allow isolation of the effects of standard education usual care from CAL. Economic and clinical outcomes of both methods should be evaluated in further research. Copyright © 2010. Published by Elsevier B.V.

ICCE/ICCAI 2000 Full & Short Papers (Interactive Learning Environments).

ERIC Educational Resources Information Center

2000

This document contains the full and short papers on interactive learning environments from ICCE/ICCAI 2000 (International Conference on Computers in Education/International Conference on Computer-Assisted Instruction) covering the following topics: a CAL system for appreciation of 3D shapes by surface development; a constructivist virtual physics…

From surprise to cognition: Some effects of the structure of C.A.L. simulation programs on the cognitive and scientific activities of young adults

NASA Astrophysics Data System (ADS)

Dicker, R. J.

The main objective of this thesis is to describe the effect on cognition of the structure of CAL simulation programs used, in science teaching. Four programs simulating a pond ecosystem were written so as to present a simulation model and to assist in cognition in different ways. Various clinically detailed methods of describing learning were developed and tried including concept maps which were found to be sammative rather than formative descriptions of learning, and to be ambiguous) and hierarchical structures (which were found to be difficult to produce). Fran these concept maps and hierarchical structures I developed my Interaction Model of Learning which can be used to describe the chronological events concerned with cognition. Using the Interaction Model, the nature of cognition and the effect that CAL program structure has on this process is described. Various scenarios are presented as a means of showing the possible effects of program structure on learning. Four forms of concept learning activity and their relationship to learning valid and alternative conceptions are described. The findings from the study are particularly related to the work of Driver (1983), Marton (1976) and Entwistle (1981).

A Functional Specification for a Programming Language for Computer Aided Learning Applications.

ERIC Educational Resources Information Center

National Research Council of Canada, Ottawa (Ontario).

In 1972 there were at least six different course authoring languages in use in Canada with little exchange of course materials between Computer Assisted Learning (CAL) centers. In order to improve facilities for producing "transportable" computer based course materials, a working panel undertook the definition of functional requirements of a user…

A CAL Program to Teach the Basic Principles of Genetic Engineering--A Change from the Traditional Approach.

ERIC Educational Resources Information Center

Dewhurst, D. G.; And Others

1989-01-01

An interactive computer-assisted learning program written for the BBC microcomputer to teach the basic principles of genetic engineering is described. Discussed are the hardware requirements software, use of the program, and assessment. (Author/CW)

Medical student preferences for self-directed study resources in gross anatomy.

PubMed

Choi-Lundberg, Derek L; Low, Tze Feng; Patman, Phillip; Turner, Paul; Sinha, Sankar N

2016-01-01

Gross anatomy instruction in medical curricula involve a range of resources and activities including dissection, prosected specimens, anatomical models, radiological images, surface anatomy, textbooks, atlases, and computer-assisted learning (CAL). These resources and activities are underpinned by the expectation that students will actively engage in self-directed study (SDS) to enhance their knowledge and understanding of anatomy. To gain insight into preclinical versus clinical medical students' preferences for SDS resources for learning gross anatomy, and whether these vary on demographic characteristics and attitudes toward anatomy, students were surveyed at two Australian medical schools, one undergraduate-entry and the other graduate-entry. Lecture/tutorial/practical notes were ranked first by 33% of 156 respondents (mean rank ± SD, 2.48 ± 1.38), textbooks by 26% (2.62 ± 1.35), atlases 20% (2.80 ± 1.44), videos 10% (4.34 ± 1.68), software 5% (4.78 ± 1.50), and websites 4% (4.24 ± 1.34). Among CAL resources, Wikipedia was ranked highest. The most important factor in selecting CAL resources was cost (ranked first by 46%), followed by self-assessment, ease of use, alignment with curriculum, and excellent graphics (each 6-9%). Compared with preclinical students, clinical students ranked software and Acland's Video Atlas of Human Anatomy higher and felt radiological images were more important in selecting CAL resources. Along with other studies reporting on the quality, features, and impact on learning of CAL resources, the diversity of students' preferences and opinions on usefulness and ease of use reported here can help guide faculty in selecting and recommending a range of CAL and other resources to their students to support their self-directed study. © 2015 American Association of Anatomists.

Medical Student Preferences for Self-Directed Study Resources in Gross Anatomy

ERIC Educational Resources Information Center

Choi-Lundberg, Derek L.; Low, Tze Feng; Patman, Phillip; Turner, Paul; Sinha, Sankar N.

2016-01-01

Gross anatomy instruction in medical curricula involve a range of resources and activities including dissection, prosected specimens, anatomical models, radiological images, surface anatomy, textbooks, atlases, and computer-assisted learning (CAL). These resources and activities are underpinned by the expectation that students will actively engage…

[Conception and implementation of a novel E-learning module with EbM learning contents in operative dentistry].

PubMed

Gerhardt-Szép, Susanne; Dreher, Stefanie; Rüttermann, Stefan; Weberschock, Tobias

2017-11-01

Computer-assisted learning (CAL) programs are becoming more widely used in medical and dental training. However, the combination of CAL programs and evidence-based education in dentistry has not been described previously. The aim was to determine the acceptance and user-friendliness of a CAL program combined with evidence-based training. The didactic concept of the module includes the case-oriented, problem-based embedding of a total of 32 EbM learning assignments, which can be completed interactively and self-determinedly in an interdisciplinary context using focus patients with different diseases. The present study was conducted at the Dental School of the Goethe University in Frankfurt/Main. Data on acceptance and user-friendliness were collected from three consecutive cohorts of 114 dental students attending their first clinical semester. They used the "Toothache Walk-in Clinic: FOCUS" CAL, which can be downloaded via the Internet. The instrument consisted of 64 statements. The first part addressed general information about the user. The second part contained 43 specific statements on the CAL program. These included factors A (handling and technical aspects), B (content and functional range), and C (didactics and suitability for education). Possible responses ranged from 0 to 3 (0 = strongly disagree, 3 = strongly agree). All of the 114 questionnaires distributed were returned (response rate 100%). Most users (90.1%) considered the topics of evidence-based dentistry important for their training. They rated the program by using German school grades, and the overall rating was 2.26 (SD = 0.64). Most students (88.6%) considered the program useful for their clinical training in the treatment of patients. The mean scores for the 43 specific items amounted to 1.90 (factor A, SD = 0.63), 1.55 (factor B, SD = 1.93), and 2.23 (factor C, SD = 0.79). The CAL program with dental medicine vignettes and learning elements for evidence-based medicine received a primarily positive assessment. Students welcome that EbM contents are offered as part of their dental studies curriculum. Copyright © 2017. Published by Elsevier GmbH.

Conceptual model of iCAL4LA: Proposing the components using comparative analysis

NASA Astrophysics Data System (ADS)

Ahmad, Siti Zulaiha; Mutalib, Ariffin Abdul

2016-08-01

This paper discusses an on-going study that initiates an initial process in determining the common components for a conceptual model of interactive computer-assisted learning that is specifically designed for low achieving children. This group of children needs a specific learning support that can be used as an alternative learning material in their learning environment. In order to develop the conceptual model, this study extracts the common components from 15 strongly justified computer assisted learning studies. A comparative analysis has been conducted to determine the most appropriate components by using a set of specific indication classification to prioritize the applicability. The results of the extraction process reveal 17 common components for consideration. Later, based on scientific justifications, 16 of them were selected as the proposed components for the model.

"M" to "Moonless": Lexical Databases in Development.

ERIC Educational Resources Information Center

Beam, Paul; Huntley, Frank

This paper describes the characteristics of lexicographic software programs used in a module on Alexander Pope's "The Rape of the Lock," a major component of a course on computer-assisted learning (CAL) at the University of Waterloo in Ontario, Canada. Two of the databases are specific to that school and are small, individualized, and…

Computer-assisted teaching of skin flap surgery: validation of a mobile platform software for medical students.

PubMed

de Sena, David P; Fabricio, Daniela D; Lopes, Maria Helena I; da Silva, Vinicius D

2013-01-01

The purpose of this study was to develop and validate a multimedia software application for mobile platforms to assist in the teaching and learning process of design and construction of a skin flap. Traditional training in surgery is based on learning by doing. Initially, the use of cadavers and animal models appeared to be a valid alternative for training. However, many conflicts with these training models prompted progression to synthetic and virtual reality models. Fifty volunteer fifth- and sixth-year medical students completed a pretest and were randomly allocated into two groups of 25 students each. The control group was exposed for 5 minutes to a standard text-based print article, while the test group used multimedia software describing how to fashion a rhomboid flap. Each group then performed a cutaneous flap on a training bench model while being evaluated by three blinded BSPS (Brazilian Society of Plastic Surgery) board-certified surgeons using the OSATS (Objective Structured Assessment of Technical Skill) protocol and answered a post-test. The text-based group was then tested again using the software. The computer-assisted learning (CAL) group had superior performance as confirmed by checklist scores (p<0.002), overall global assessment (p = 0.017) and post-test results (p<0.001). All participants ranked the multimedia method as the best study tool. CAL learners exhibited better subjective and objective performance when fashioning rhomboid flaps as compared to those taught with standard print material. These findings indicate that students preferred to learn using the multimedia method.

Design Considerations for the Development of Interactive Video (IV) in Nurse Education.

ERIC Educational Resources Information Center

Chandra, Peter; And Others

A computer assisted learning (CAL) program in the area of intravenous drug administration developed by the Nightingale Project is currently being used in a number of nursing schools and hospitals throughout the United Kingdom. The success of this program and the emergence of interactive video as a significant training medium persuaded the…

Searching for evidence of curricular effect on the teaching and learning of mathematics: some insights from the LieCal project

NASA Astrophysics Data System (ADS)

Cai, Jinfa

2014-12-01

Drawing on evidence from the Longitudinal Investigation of the Effect of Curriculum on Algebra Learning (LieCal) Project, issues related to mathematics curriculum reform and student learning are discussed. The LieCal Project was designed to longitudinally investigate the impact of a reform mathematics curriculum called the Connected Mathematics Project (CMP) in the USA on teachers' teaching and students' learning. Using a three-level conceptualization of curriculum (intended, implemented, and attained), a variety of evidence from the LieCal Project is presented to show the impact of mathematics curriculum reform on teachers' teaching and students' learning. This paper synthesizes findings from the two longitudinal studies spanning 7 years of the LieCal Project both to show the kind of impact curriculum has on teachers' teaching and students' learning and to suggest powerful but feasible ways researchers can investigate curriculum effect on both teaching and learning.

Teaching Neuroanatomy Using Computer-Aided Learning: What Makes for Successful Outcomes?

ERIC Educational Resources Information Center

Svirko, Elena; Mellanby, Jane

2017-01-01

Computer-aided learning (CAL) is an integral part of many medical courses. The neuroscience course at Oxford University for medical students includes CAL course of neuroanatomy. CAL is particularly suited to this since neuroanatomy requires much detailed three-dimensional visualization, which can be presented on screen. The CAL course was…

Committee-Based Active Learning for Surrogate-Assisted Particle Swarm Optimization of Expensive Problems.

PubMed

Wang, Handing; Jin, Yaochu; Doherty, John

2017-09-01

Function evaluations (FEs) of many real-world optimization problems are time or resource consuming, posing a serious challenge to the application of evolutionary algorithms (EAs) to solve these problems. To address this challenge, the research on surrogate-assisted EAs has attracted increasing attention from both academia and industry over the past decades. However, most existing surrogate-assisted EAs (SAEAs) either still require thousands of expensive FEs to obtain acceptable solutions, or are only applied to very low-dimensional problems. In this paper, a novel surrogate-assisted particle swarm optimization (PSO) inspired from committee-based active learning (CAL) is proposed. In the proposed algorithm, a global model management strategy inspired from CAL is developed, which searches for the best and most uncertain solutions according to a surrogate ensemble using a PSO algorithm and evaluates these solutions using the expensive objective function. In addition, a local surrogate model is built around the best solution obtained so far. Then, a PSO algorithm searches on the local surrogate to find its optimum and evaluates it. The evolutionary search using the global model management strategy switches to the local search once no further improvement can be observed, and vice versa. This iterative search process continues until the computational budget is exhausted. Experimental results comparing the proposed algorithm with a few state-of-the-art SAEAs on both benchmark problems up to 30 decision variables as well as an airfoil design problem demonstrate that the proposed algorithm is able to achieve better or competitive solutions with a limited budget of hundreds of exact FEs.

Teaching neuroanatomy using computer-aided learning: What makes for successful outcomes?

PubMed

Svirko, Elena; Mellanby, Jane

2017-11-01

Computer-aided learning (CAL) is an integral part of many medical courses. The neuroscience course at Oxford University for medical students includes CAL course of neuroanatomy. CAL is particularly suited to this since neuroanatomy requires much detailed three-dimensional visualization, which can be presented on screen. The CAL course was evaluated using the concept of approach to learning. The aims of university teaching are congruent with the deep approach-seeking meaning and relating new information to previous knowledge-rather than to the surface approach of concentrating on rote learning of detail. Seven cohorts of medical students (N = 869) filled in approach to learning scale and a questionnaire investigating their engagement with the CAL course. The students' scores on CAL-course-based neuroanatomy assessment and later university examinations were obtained. Although the students reported less use of the deep approach for the neuroanatomy CAL course than for the rest of their neuroanatomy course (mean = 24.99 vs. 31.49, P < 0.001), deep approach for CAL was positively correlated with neuroanatomy assessment performance (r = 0.12, P < 0.001). Time spent on the CAL course, enjoyment of it, the amount of CAL videos watched and quizzes completed were each significantly positively related to deep approach. The relationship between deep approach and enjoyment was particularly notable (25.5% shared variance). Reported relationships between deep approach and academic performance support the desirability of deep approach in university students. It is proposed that enjoyment of the course and the deep approach could be increased by incorporation of more clinical material which is what the students liked most. Anat Sci Educ 10: 560-569. © 2017 American Association of Anatomists. © 2017 American Association of Anatomists.

TAIGA: Twente Advanced Interactive Graphic Authoring System. A New Concept in Computer Assisted Learning (CAL) and Educational Research. Doc 88-18.

ERIC Educational Resources Information Center

Pilot, A.

TAIGA (Twente Advanced Interactive Graphic Authoring system) is a system which can be used to develop instructional software. It is written in MS-PASCAL, and runs on computers that support MS-DOS. Designed to support the production of structured software, TAIGA has a hierarchical structure of three layers, each with a specific function, and each…

Design and validation of a computer-aided learning program to enhance students' ability to recognize lameness in the horse.

PubMed

Barstow, Amy; Pfau, Thilo; Bolt, David M; Smith, Roger K; Weller, Renate

2014-01-01

The ability to recognize lameness in the horse is an important skill for veterinary graduates; however, opportunities to develop this skill at the undergraduate level are limited. Computer-aided learning programs (CALs) have been successful in supplementing practical skills teaching. The aim of this study was to design and validate a CAL for the teaching of equine lameness recognition (CAL1). A control CAL was designed to simulate learning by experience (CAL2). Student volunteers were randomly assigned to either CAL and tested to establish their current ability to recognize lameness. Retesting occurred both immediately following exposure and 1 week later. At each test point, the number of correct responses for forelimb and hind limb cases was determined. Student confidence was assessed before and after CAL exposure, with previous opportunities to recognize lameness taken into account. Immediately following exposure, the number of correct responses was significantly higher for CAL1 than for CAL2, both overall and for forelimb cases but not for hind limb cases. After 1 week, the CAL1 group performed significantly better overall compared to the CAL2 group, with no significant difference between forelimb and hind limb cases. Student confidence and ability to recognize lameness were significantly improved following exposure to CAL1. When considered as one category, students in years 4 and 5 performed significantly better than year 3 students. Gender did not significantly affect performance. CAL1 could be used to supplement current lameness recognition opportunities. CAL1 is, however, limited in its ability to improve lameness recognition, especially in relation to hind limb lameness where it was unable to attain a significant difference from CAL2.

Potential drawbacks in cell-assisted lipotransfer: A systematic review of existing reports (Review)

PubMed Central

HUANG, SHENG; ZHAO, WEILIANG; WANG, ZIHUA; TAO, KAI; LIU, XIAOYAN; CHANG, PENG

2016-01-01

Cell-assisted lipotransfer (CAL) has been widely used in various clinical applications, including breast augmentation following mammectomy, soft-tissue reconstruction and wound healing. However, the clinical application of CAL has been restricted due to the transplanted fat tissues being readily liquefied and absorbed. The present review examines 57 previously published studies involving CAL, including fat grafting or fat transfer with human adipose-stem cells in all known databases. Of these 57 articles, seven reported the clinical application of CAL. In the 57 studies, the majority of the fat tissues were obtained from the abdomen via liposuction of the seven clinical studies, four were performed in patients requiring breast augmentation, one in a patient requiring facial augmentation, one in a patient requiring soft tissue augmentation/reconstruction and one in a patient requiring fat in their upper arms. Despite the potential risks, there has been an increased demand for CAL in in cosmetic or aesthetic applications. Thus, criteria and guidelines are necessary for the clinical application of CAL technology. PMID:26677061

Cooperation Support in Computer-Aided Authoring and Learning.

ERIC Educational Resources Information Center

Muhlhauser, Max; Rudebusch, Tom

This paper discusses the use of Computer Supported Cooperative Work (CSCW) techniques for computer-aided learning (CAL); the work was started in the context of project Nestor, a joint effort of German universities about cooperative multimedia authoring/learning environments. There are four major categories of cooperation for CAL: author/author,…

Proceedings of the NASTRAN (Tradename) Users’ Colloquium (18th) Held in Portland, Oregon on 23-27 April 1990

DTIC Science & Technology

1990-04-01

Maxwell (Texas A&M University-) 4. ACCURACY OF THE QUAD& THICK SHELL ELEMENT ’........... .. 3.0 by William R. Case, Tiffany D. Bowles, Al ia K. Croft and...Computer Literacy: Mainframe Monsters and Pacman. Symposium on Advances and Trends in Structures and Dynamics, Washington, D.C., October 1984. 4. Woodward...No. 1, 1985. 5. Wilson, E.L., and M. Holt: CAL-80-Computer Assisted Learning of Structural Engineering. Symposium on Advances and Trends in

Enhancing a Multi-body Mechanism with Learning-Aided Cues in an Augmented Reality Environment

NASA Astrophysics Data System (ADS)

Singh Sidhu, Manjit

2013-06-01

Augmented Reality (AR) is a potential area of research for education, covering issues such as tracking and calibration, and realistic rendering of virtual objects. The ability to augment real world with virtual information has opened the possibility of using AR technology in areas such as education and training as well. In the domain of Computer Aided Learning (CAL), researchers have long been looking into enhancing the effectiveness of the teaching and learning process by providing cues that could assist learners to better comprehend the materials presented. Although a number of works were done looking into the effectiveness of learning-aided cues, but none has really addressed this issue for AR-based learning solutions. This paper discusses the design and model of an AR based software that uses visual cues to enhance the learning process and the outcome perception results of the cues.

Critical by Design: Enacting Critical Action Learning in a Small Business Context

ERIC Educational Resources Information Center

Ram, Monder; Trehan, Kiran

2009-01-01

A small but growing strand of literature is beginning to make the case for "critical action learning" (CAL). Much of this interest operates on theoretical terrain, speculating on the extent to which it might differ from more conventional notions of action learning. This paper draws on insights from (CAL) to demonstrate the importance of being…

Cell-assisted lipotransfer: Friend or foe in fat grafting? Systematic review and meta-analysis.

PubMed

Laloze, J; Varin, A; Gilhodes, J; Bertheuil, N; Grolleau, J L; Brie, J; Usseglio, J; Sensebe, L; Filleron, T; Chaput, B

2018-02-01

Autologous fat grafting is a common procedure for soft-tissue reconstruction but is associated with a graft resorption rate ranging from 20% to 80%. To improve the fat graft survival rate, a new technique, called cell-assisted lipotransfer (CAL), was developed. With CAL, fat is injected along with adipose-derived stromal cells that are assumed to improve fat survival rate. We conducted an evidence-based meta-analysis to evaluate the efficacy and safety of CAL as compared with conventional autologous fat grafting (non-CAL). The databases MEDLINE (via PubMed), Cochrane Library, EBSCO, Web of Science, and EMBASE were searched for reports of clinical trials, case series, and cohorts available from 2008 to 2016. We conducted a meta-analysis of the efficacy of CAL with data analysis concerning fat survival rate. The incidence of complications and the need for multiple procedures were evaluated to determine the safety of CAL. We identified 25 studies (696 patients) that were included in the systematic review; 16 studies were included in the meta-analysis to evaluate the efficacy of CAL. The fat survival rate was significantly higher with CAL than non-CAL (64% vs. 44%, p < .0001) independent of injection site (breast and face). This benefit of CAL was significant for only injection volumes <100 ml (p = .03). The two groups did not differ in frequency of multiple procedures after fat grafting, but the incidence of complications was greater with CAL than non-CAL (8.4% vs. 1.5%, p = .0019). The CAL method is associated with better fat survival rate than with conventional fat grafting but only for small volumes of fat grafting (<100 ml). Nonetheless, the new technique is associated with more complications and did not reduce the number of surgical procedures needed after the first fat grafting. More prospective studies are required to draw clinical conclusions and to demonstrate the real benefit of CAL as compared with common autologous fat grafting. Copyright © 2017 John Wiley & Sons, Ltd.

A Web-Based Computer-Aided Learning Module for an Anatomy Course Using Open Source Image Mapping Software

ERIC Educational Resources Information Center

Carleton, Renee E.

2012-01-01

Computer-aided learning (CAL) is used increasingly to teach anatomy in post-secondary programs. Studies show that augmentation of traditional cadaver dissection and model examination by CAL can be associated with positive student learning outcomes. In order to reduce costs associated with the purchase of skeletons and models and to encourage study…

CTN summary of DSREDS, EDCARS, EDMICS CALS readiness testing. [Computer-aided Acquisition and Logistic Support (CALS) CALS Test Network (CTN), Digital Storage Retrieval Eng. Data System (DSREDS), Eng. Data Computer Assisted Retrieval System (EDCARS), Eng. Data Management Information and Control System (EDMICS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitschkowetz, N.; Vickers, D.L.

This report provides a summary of the Computer-aided Acquisition and Logistic Support (CALS) Test Network (CTN) Laboratory Acceptance Test (LAT) and User Application Test (UAT) activities undertaken to evaluate the CALS capabilities being implemented as part of the Department of Defense (DOD) engineering repositories. Although the individual testing activities provided detailed reports for each repository, a synthesis of the results, conclusions, and recommendations is offered to provide a more concise presentation of the issues and the strategies, as viewed from the CTN perspective.

Spanish-language community-based mental health treatment programs, policy-required language-assistance programming, and mental health treatment access among Spanish-speaking clients.

PubMed

Snowden, Lonnie R; McClellan, Sean R

2013-09-01

We investigated the extent to which implementing language assistance programming through contracting with community-based organizations improved the accessibility of mental health care under Medi-Cal (California's Medicaid program) for Spanish-speaking persons with limited English proficiency, and whether it reduced language-based treatment access disparities. Using a time series nonequivalent control group design, we studied county-level penetration of language assistance programming over 10 years (1997-2006) for Spanish-speaking persons with limited English proficiency covered under Medi-Cal. We used linear regression with county fixed effects to control for ongoing trends and other influences. When county mental health plans contracted with community-based organizations, those implementing language assistance programming increased penetration rates of Spanish-language mental health services under Medi-Cal more than other plans (0.28 percentage points, a 25% increase on average; P < .05). However, the increase was insufficient to significantly reduce language-related disparities. Mental health treatment programs operated by community-based organizations may have moderately improved access after implementing required language assistance programming, but the programming did not reduce entrenched disparities in the accessibility of mental health services.

Spanish-Language Community-Based Mental Health Treatment Programs, Policy-Required Language-Assistance Programming, and Mental Health Treatment Access Among Spanish-Speaking Clients

PubMed Central

McClellan, Sean R.

2013-01-01

Objectives. We investigated the extent to which implementing language assistance programming through contracting with community-based organizations improved the accessibility of mental health care under Medi-Cal (California’s Medicaid program) for Spanish-speaking persons with limited English proficiency, and whether it reduced language-based treatment access disparities. Methods. Using a time series nonequivalent control group design, we studied county-level penetration of language assistance programming over 10 years (1997–2006) for Spanish-speaking persons with limited English proficiency covered under Medi-Cal. We used linear regression with county fixed effects to control for ongoing trends and other influences. Results. When county mental health plans contracted with community-based organizations, those implementing language assistance programming increased penetration rates of Spanish-language mental health services under Medi-Cal more than other plans (0.28 percentage points, a 25% increase on average; P < .05). However, the increase was insufficient to significantly reduce language-related disparities. Conclusions. Mental health treatment programs operated by community-based organizations may have moderately improved access after implementing required language assistance programming, but the programming did not reduce entrenched disparities in the accessibility of mental health services. PMID:23865663

Computer-based teaching module design: principles derived from learning theories.

PubMed

Lau, K H Vincent

2014-03-01

The computer-based teaching module (CBTM), which has recently gained prominence in medical education, is a teaching format in which a multimedia program serves as a single source for knowledge acquisition rather than playing an adjunctive role as it does in computer-assisted learning (CAL). Despite empirical validation in the past decade, there is limited research into the optimisation of CBTM design. This review aims to summarise research in classic and modern multimedia-specific learning theories applied to computer learning, and to collapse the findings into a set of design principles to guide the development of CBTMs. Scopus was searched for: (i) studies of classic cognitivism, constructivism and behaviourism theories (search terms: 'cognitive theory' OR 'constructivism theory' OR 'behaviourism theory' AND 'e-learning' OR 'web-based learning') and their sub-theories applied to computer learning, and (ii) recent studies of modern learning theories applied to computer learning (search terms: 'learning theory' AND 'e-learning' OR 'web-based learning') for articles published between 1990 and 2012. The first search identified 29 studies, dominated in topic by the cognitive load, elaboration and scaffolding theories. The second search identified 139 studies, with diverse topics in connectivism, discovery and technical scaffolding. Based on their relative representation in the literature, the applications of these theories were collapsed into a list of CBTM design principles. Ten principles were identified and categorised into three levels of design: the global level (managing objectives, framing, minimising technical load); the rhetoric level (optimising modality, making modality explicit, scaffolding, elaboration, spaced repeating), and the detail level (managing text, managing devices). This review examined the literature in the application of learning theories to CAL to develop a set of principles that guide CBTM design. Further research will enable educators to take advantage of this unique teaching format as it gains increasing importance in medical education. © 2014 John Wiley & Sons Ltd.

An Interaction of Screen Colour and Lesson Task in CAL

ERIC Educational Resources Information Center

Clariana, Roy B.

2004-01-01

Colour is a common feature in computer-aided learning (CAL), though the instructional effects of screen colour are not well understood. This investigation considers the effects of different CAL study tasks with feedback on posttest performance and on posttest memory of the lesson colour scheme. Graduate students (n=68) completed a computer-based…

Remote-online case-based learning: A comparison of remote-online and face-to-face, case-based learning - a randomized controlled trial.

PubMed

Nicklen, Peter; Keating, Jenny L; Paynter, Sophie; Storr, Michael; Maloney, Stephen

2016-01-01

Case-based learning (CBL) is an educational approach where students work in small, collaborative groups to solve problems. Computer assisted learning (CAL) is the implementation of computer technology in education. The purpose of this study was to compare the effects of a remote-online CBL (RO-CBL) with traditional face-to-face CBL on learning the outcomes of undergraduate physiotherapy students. Participants were randomized to either the control (face-to-face CBL) or to the CAL intervention (RO-CBL). The entire 3rd year physiotherapy cohort (n = 41) at Monash University, Victoria, Australia, were invited to participate in the randomized controlled trial. Outcomes included a postintervention multiple-choice test evaluating the knowledge gained from the CBL, a self-assessment of learning based on examinable learning objectives and student satisfaction with the CBL. In addition, a focus group was conducted investigating perceptions and responses to the online format. Thirty-eight students (control n = 19, intervention n = 19) participated in two CBL sessions and completed the outcome assessments. CBL median scores for the postintervention multiple-choice test were comparable (Wilcoxon rank sum P = 0.61) (median/10 [range] intervention group: 9 [8-10] control group: 10 [7-10]). Of the 15 examinable learning objectives, eight were significantly in favor of the control group, suggesting a greater perceived depth of learning. Eighty-four percent of students (16/19) disagreed with the statement "I enjoyed the method of CBL delivery." Key themes identified from the focus group included risks associated with the implementation of, challenges of communicating in, and flexibility offered, by web-based programs. RO-CBL appears to provide students with a comparable learning experience to traditional CBL. Procedural and infrastructure factors need to be addressed in future studies to counter student dissatisfaction and decreased perceived depth of learning.

Digital Academic Revolution Mentorship Competency: #1 The Declaration--Mentoring the Process of Learning with Screencast Assessment--Plugging into Students' Digital DNA a Decade Later

ERIC Educational Resources Information Center

Mehl, Martin; Fose, Luanne

2016-01-01

Spanning the 2015-2016 academic year, Cal Poly Communications Studies Sr. Lecturer, Martin Mehl, and Lead Instructional Designer, Luanne Fose, from the Cal Poly Center for Teaching, Learning, and Technology, conducted a formal, institute-wide research pilot on whether or not video assessment can improve faculty feedback for student assignments.…

Operator assistant to support deep space network link monitor and control

NASA Technical Reports Server (NTRS)

Cooper, Lynne P.; Desai, Rajiv; Martinez, Elmain

1992-01-01

Preparing the Deep Space Network (DSN) stations to support spacecraft missions (referred to as pre-cal, for pre-calibration) is currently an operator and time intensive activity. Operators are responsible for sending and monitoring several hundred operator directivities, messages, and warnings. Operator directives are used to configure and calibrate the various subsystems (antenna, receiver, etc.) necessary to establish a spacecraft link. Messages and warnings are issued by the subsystems upon completion of an operation, changes of status, or an anomalous condition. Some points of pre-cal are logically parallel. Significant time savings could be realized if the existing Link Monitor and Control system (LMC) could support the operator in exploiting the parallelism inherent in pre-cal activities. Currently, operators may work on the individual subsystems in parallel, however, the burden of monitoring these parallel operations resides solely with the operator. Messages, warnings, and directives are all presented as they are received; without being correlated to the event that triggered them. Pre-cal is essentially an overhead activity. During pre-cal, no mission is supported, and no other activity can be performed using the equipment in the link. Therefore, it is highly desirable to reduce pre-cal time as much as possible. One approach to do this, as well as to increase efficiency and reduce errors, is the LMC Operator Assistant (OA). The LMC OA prototype demonstrates an architecture which can be used in concert with the existing LMC to exploit parallelism in pre-cal operations while providing the operators with a true monitoring capability, situational awareness and positive control. This paper presents an overview of the LMC OA architecture and the results from initial prototyping and test activities.

Survey for rural transit assistance program.

DOT National Transportation Integrated Search

2006-02-01

Currently, the California Association for Coordinated Transportation Inc. (CalACT) is under contract to the Department of Transportation, Division of Mass Transportation (DMT) to implement all aspects of Rural Transit Assistance Program. (RTAP). RTAP...

Computer assisted learning (CAL) of oral manifestations of HIV disease.

PubMed

Porter, S R; Telford, A; Chandler, K; Furber, S; Williams, J; Price, S; Scully, C; Triantos, D; Bain, L

1996-09-07

General dental practitioners (GDPs) in the UK may wish additional education on relevant aspects of human immunodeficiency virus (HIV) disease. The aim of the present study was to develop and assess a computer assisted learning package on the oral manifestations of HIV disease of relevance to GDPs. A package was developed using a commercially-available software development tool and assessed by a group of 75 GDPs interested in education and computers. Fifty-four (72%) of the GDPs completed a self-administered questionnaire of their opinions of the package. The majority reported the package to be easy to load and run, that it provided clear instructions and displays, and that it was a more effective educational tool than videotapes, audiotapes, professional journals and textbooks, and of similar benefit as post-graduate courses. The GDPs often commented favourably on the effectiveness of the clinical images and use of questions and answers, although some had criticisms of these and other aspects of the package. As a consequence of this investigation the package has been modified and distributed to GDPs in England and Wales.

Communication in the Chinese Classroom.

ERIC Educational Resources Information Center

Ngwainmbi, Emmanuel K.

2004-01-01

This study investigates cultural (idiosyncratic, linguistic) aspects of interpersonal & cross-cultural interactions in a Chinese learning environment. It explains the relationship between the Chinese academic community (CAL) in a university in Beijing, China and American professors (AAS) and how the CAL negotiates meaning through verbal…

Energy, Sustainability, Collaboration: Learning it, Teaching it, and Living it -- At Cal Poly, in Guatemala, and at Home

NASA Astrophysics Data System (ADS)

Schwartz, Pete

2012-11-01

Three questions have become important to me: *``What is the future of our energy dilemma, and how can I participate toward a solution?'' Since 2007, I have been teaching ``Energy, Society, and the Environment'' at Cal Poly as well as developing and analyzing renewable energy technologies. In the process I have learned as much as my students. This interest was initially sparked by making ``sustainable'' changes to my home and lifestyle, and has since fueled constant domestic experimentation. *The above question extends to ``Environmental Justice'', which is essentially a question of ``who benefits and who suffers as a result of our societal choices?'' For the past three years, I've developed and directed a collaborative (Guatemalan/Cal Poly) appropriate technology field school. Students from both countries learn together during the two-month summer program in a small mountain village in Guatemala (www.guateca.com). *``What happens to learning efficacy when students become friends?'' For the past three years, I've been actively engaged with a group of Cal Poly instructors in a quest to create community in the learning environment (www.sustainslo.org). Additionally, I've begun to teach all my classes ``inside out'', consistent with the advice of Physics Nobel Prize Laureate Carl Weiman (Science, 13 May 2011, VOL 332 862 -- 864). Students learn the material at home by reading or watching videos available on the web. This opens up class time for guided discussion, experimentation, and calculations. The Guateca field school provides an extreme example of this principle, as all the students do become friends. with very interesting results.

Understanding neurophobia: Reasons behind impaired understanding and learning of neuroanatomy in cross-disciplinary healthcare students.

PubMed

Javaid, Muhammad Asim; Chakraborty, Shelly; Cryan, John F; Schellekens, Harriët; Toulouse, André

2018-01-01

Recent studies have highlighted a fear or difficulty with the study and understanding of neuroanatomy among medical and healthcare students. This has been linked with a diminished confidence of clinical practitioners and students to manage patients with neurological conditions. The underlying reasons for this difficulty have been queried among a broad cohort of medical, dental, occupational therapy, and speech and language sciences students. Direct evidence of the students' perception regarding specific difficulties associated with learning neuroanatomy has been provided and some of the measures required to address these issues have been identified. Neuroanatomy is perceived as a more difficult subject compared to other anatomy topics (e.g., reproductive/pelvic anatomy) and not all components of the neuroanatomy curriculum are viewed as equally challenging. The difficulty in understanding neuroanatomical concepts is linked to intrinsic factors such as the inherent complex nature of the topic rather than outside influences (e.g., lecture duration). Participants reporting high levels of interest in the subject reported higher levels of knowledge, suggesting that teaching tools aimed at increasing interest, such as case-based scenarios, could facilitate acquisition of knowledge. Newer pedagogies, including web-resources and computer assisted learning (CAL) are considered important tools to improve neuroanatomy learning, whereas traditional tools such as lecture slides and notes were considered less important. In conclusion, it is suggested that understanding of neuroanatomy could be enhanced and neurophobia be decreased by purposefully designed CAL resources. This data could help curricular designers to refocus attention and guide educators to develop improved neuroanatomy web-resources in future. Anat Sci Educ 11: 81-93. © 2017 American Association of Anatomists. © 2017 American Association of Anatomists.

CalTOX (registered trademark), A multimedia total exposure model spreadsheet user's guide. Version 4.0(Beta)

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKone, T.E.; Enoch, K.G.

2002-08-01

CalTOX has been developed as a set of spreadsheet models and spreadsheet data sets to assist in assessing human exposures from continuous releases to multiple environmental media, i.e. air, soil, and water. It has also been used for waste classification and for setting soil clean-up levels at uncontrolled hazardous wastes sites. The modeling components of CalTOX include a multimedia transport and transformation model, multi-pathway exposure scenario models, and add-ins to quantify and evaluate uncertainty and variability. All parameter values used as inputs to CalTOX are distributions, described in terms of mean values and a coefficient of variation, rather than asmore » point estimates or plausible upper values such as most other models employ. This probabilistic approach allows both sensitivity and uncertainty analyses to be directly incorporated into the model operation. This manual provides CalTOX users with a brief overview of the CalTOX spreadsheet model and provides instructions for using the spreadsheet to make deterministic and probabilistic calculations of source-dose-risk relationships.« less

Guide to Simulation Scheduling. Appendices B and C,

DTIC Science & Technology

1986-01-01

2v502) lEARN ,ElA7L CAL03120 YEAkN=YEAKN4I CAL03130 610 COKT14UE CALO-1140 C 502 FOkt T IX/,1XYLAR m lo g 93113 ol2 i X, MCI 1H= 19 2 o1 X 3113) CAL0315,O...1791777#END=777) NRAND MICCO650 GC 10l 778 MIC00660 * 777 WR17E(6,0) I PLEASE ENTER A NUMBER FO FANDOM NUMBER CEIEkATION’ M1C00670 REAC(59*) NRAND

NATAL-74; Towards a Common Programming Language for CAL.

ERIC Educational Resources Information Center

Brahan, J. W.; Colpitts, B. A.

NATAL-74 is a programing language designed for Canadian computer aided learning (CAL) programs. The language has two fundamental elements: the UNIT provides the interface between the student and the subject matter, and the PROCEDURE element embodies teaching strategy. Desirable features of several programing languages have been adapted to cope…

Object-oriented design and implementation of CFDLab: a computer-assisted learning tool for fluid dynamics using dual reciprocity boundary element methodology

NASA Astrophysics Data System (ADS)

Friedrich, J.

1999-08-01

As lecturers, our main concern and goal is to develop more attractive and efficient ways of communicating up-to-date scientific knowledge to our students and facilitate an in-depth understanding of physical phenomena. Computer-based instruction is very promising to help both teachers and learners in their difficult task, which involves complex cognitive psychological processes. This complexity is reflected in high demands on the design and implementation methods used to create computer-assisted learning (CAL) programs. Due to their concepts, flexibility, maintainability and extended library resources, object-oriented modeling techniques are very suitable to produce this type of pedagogical tool. Computational fluid dynamics (CFD) enjoys not only a growing importance in today's research, but is also very powerful for teaching and learning fluid dynamics. For this purpose, an educational PC program for university level called 'CFDLab 1.1' for Windows™ was developed with an interactive graphical user interface (GUI) for multitasking and point-and-click operations. It uses the dual reciprocity boundary element method as a versatile numerical scheme, allowing to handle a variety of relevant governing equations in two dimensions on personal computers due to its simple pre- and postprocessing including 2D Laplace, Poisson, diffusion, transient convection-diffusion.

Teaching Computer-Aided Design of Fluid Flow and Heat Transfer Engineering Equipment.

ERIC Educational Resources Information Center

Gosman, A. D.; And Others

1979-01-01

Describes a teaching program for fluid mechanics and heat transfer which contains both computer aided learning (CAL) and computer aided design (CAD) components and argues that the understanding of the physical and numerical modeling taught in the CAL course is essential to the proper implementation of CAD. (Author/CMV)

The Effectiveness of Computer-Aid, Self-Instructional Programs in Dental Education: A Systematic Review of the Literature.

ERIC Educational Resources Information Center

Rosenberg, Harold; Grad, Helen A.; Matear, David W.

2003-01-01

Performed a systematic review of the published literature comparing computer-aided learning (CAL) with other teaching methods in dental education. Concluded that CAL is as effective as other methods of teaching and can be used as an adjunct to traditional education or as a means of self-instruction. (EV)

Hospital Selective Contracting without Consumer Choice: What Can We Learn from Medi-Cal?

ERIC Educational Resources Information Center

Bamezai, Anil; Melnick, Glenn A.; Mann, Joyce M.; Zwanziger, Jack

2003-01-01

In the selective contracting era, consumer choice has generally been absent in most state Medicaid programs, including California's (called Medi-Cal). In a setting where beneficiary exit is not a threat, a large payer may have both the incentives and the ability to exercise undue market power, potentially exposing an already vulnerable population…

Health Promotion Interventions for Low-Income Californians Through Medi-Cal Managed Care Plans, 2012

PubMed Central

Kohatsu, Neal D.; Paciotti, Brian M.; Byrne, Jennifer V.; Kizer, Kenneth W.

2015-01-01

Introduction Prevention is the most cost-effective approach to promote population health, yet little is known about the delivery of health promotion interventions in the nation’s largest Medicaid program, Medi-Cal. The purpose of this study was to inventory health promotion interventions delivered through Medi-Cal Managed Care Plans; identify attributes of the interventions that plans judged to have the greatest impact on their members; and determine the extent to which the plans refer members to community assistance programs and sponsor health-promoting community activities. Methods The lead health educator from each managed care plan was asked to complete a 190-item online survey in January 2013; 20 of 21 managed care plans responded. Survey data on the health promotion interventions with the greatest impact were grouped according to intervention attributes and measures of effectiveness; quantitative data were analyzed using descriptive statistics. Results Health promotion interventions judged to have the greatest impact on Medi-Cal members were delivered in various ways; educational materials, one-on-one education, and group classes were delivered most frequently. Behavior change, knowledge gain, and improved disease management were cited most often as measures of effectiveness. Across all interventions, median educational hours were limited (2.4 h), and median Medi-Cal member participation was low (265 members per intervention). Most interventions with greatest impact (120 of 137 [88%]) focused on tertiary prevention. There were mixed results in referring members to community assistance programs and investing in community activities. Conclusion Managed care plans have many opportunities to more effectively deliver health promotion interventions. Establishing measurable, evidence-based, consensus standards for such programs could facilitate improved delivery of these services. PMID:26564012

Critical Action Learning: Extending Its Reach

ERIC Educational Resources Information Center

Ram, Monder

2012-01-01

The trend to imbue action learning with an explicit conception of criticality appears to be gathering momentum. The idea of critical action learning (CAL) foregrounds the connection between power, emotion and organizing. How this triumvirate of forces relate to each other fundamentally shapes the scope for learning. Theoretical and empirical…

Partners in Success for Young Adolescents: The Cal Ripken, Sr. Foundation and National Middle School Association

ERIC Educational Resources Information Center

Chan, Janice

2007-01-01

Middle school students are at a critical point in their lives. One way or another they are learning the decision-making and coping skills that they will use as adults. To be successful they need guidance from caring teachers, parents, coaches, and other significant adults who are positive role models. For Cal Ripken, Jr. and his brother Bill, it…

Finding Spirituality through Confrontation and Celebration of Asianness in the Classroom

ERIC Educational Resources Information Center

Hao, Richie Neil

2009-01-01

One September morning, the author woke as a teacher--an international teaching assistant (ITA), to be exact--at a California State University (Cal State). As a twenty-five-year-old teaching assistant, he had the opportunity to teach hybrid public speaking classes that were designed for the American Culture and Language Program (ACLP), which turned…

Differences in Learning Styles and Satisfaction between Traditional Face-to-Face and Online Web-Based Sport Management Studies Students

ERIC Educational Resources Information Center

West, Ellen Jo

2010-01-01

Each student has a unique learning style or individual way of perceiving, interacting, and responding to a learning environment. The purpose of this study was to identify and compare the prevalence of learning styles among undergraduate Sport Management Studies (SMS) students at California University of Pennsylvania (Cal U). Learning style…

Enacting Critical Learning: Power, Politics and Emotions at Work

ERIC Educational Resources Information Center

Trehan, Kiran; Rigg, Clare

2015-01-01

This article seeks to develop the understanding of critical action learning (CAL) and to make a contribution to its theory and practice. The article begins by conceptualising critical action learning and builds on the work of Revans (1982) to stimulate fresh thinking. It provides a different calibration of his coupling of action and learning. An…

Dental Assistant, AFSC 981X0

DTIC Science & Technology

1989-03-01

career ladder assist dental officers in the performance of restorative, endodontic, orthodontic , pedodontic, periodontic, prosthodontic, and dental...representative location for orthodontic , pedodontic, and medi- cal readiness functions Randolph AFB TX Typical USAF Clinic In addition to interviews at the...the 2,230 personnel surveyed and are listed below. The relative time spent by respondents in each duty is pre - sented in Table 3. Selected background

CALS Tech Bulletin #3. An Occasional Publication of the Center for Advanced Learning Systems.

ERIC Educational Resources Information Center

CSR, Inc., Washington, DC.

This paper contains brief synopses of recent technical progress/projects in the field of advanced learning systems. This issue contains the following 12 items: (1) "Guest Editorial" (Sylvia Charp) concerning the need to provide better learning experiences for all students; (2) "Steps in Developing an Expert Systems Model," as…

IDR: A Participatory Methodology for Interdisciplinary Design in Technology Enhanced Learning

ERIC Educational Resources Information Center

Winters, Niall; Mor, Yishay

2008-01-01

One of the important themes that emerged from the CAL'07 conference was the failure of technology to bring about the expected disruptive effect to learning and teaching. We identify one of the causes as an inherent weakness in prevalent development methodologies. While the problem of designing technology for learning is irreducibly…

Participating in a Collaborative Action Learning Set (CAL): Beginning the Journey

ERIC Educational Resources Information Center

McCormack, Brendan; Henderson, Elizabeth; Boomer, Christine; Collin, Ita; Robinson, David

2008-01-01

Action learning is being increasingly utilised as a strategy to underpin practitioner focused development and research projects in healthcare generally and nursing in particular. Whilst facilitators of and participants in action learning have a variety of resource materials to guide their practice and participation, there continue to be few…

Learning Styles and Formative Assessment Strategy: Enhancing Student Achievement in Web-Based Learning

ERIC Educational Resources Information Center

Wang, K. H.; Wang, T. H.; Wang, W. L.; Huang, S. C.

2006-01-01

The purpose of this research was to investigate the effects of formative assessment and learning style on student achievement in a Web-based learning environment. A quasi-experimental research design was used. Participants were 455 seventh grade students from 12 classes of six junior high schools. A Web-based course, named BioCAL, combining three…

Transferring Technology to Industry

NASA Technical Reports Server (NTRS)

Wolfenbarger, J. Ken

2006-01-01

This slide presentation reviews the technology transfer processes in which JPL has been involved to assist in transferring the technology derived from aerospace research and development to industry. California Institute of Technology (CalTech), the organization that runs JPL, is the leading institute in patents for all U.S. universities. There are several mechanisms that are available to JPL to inform industry of these technological advances: (1) a dedicated organization at JPL, National Space Technology Applications (NSTA), (2) Tech Brief Magazine, (3) Spinoff magazine, and (4) JPL publications. There have also been many start-up organizations and businesses from CalTech.

Scientific Reasoning for Pre-service Elementary Teachers

NASA Astrophysics Data System (ADS)

Sadaghiani, Homeyra R.

2010-10-01

The objectives of K-12 teacher education science courses often focus on conceptual learning and improving students overall attitude towards science. It is often assumed that with the use of research-based curriculum material and more hands on inquiry approaches, without any explicit instruction, student scientific and critical thinking skills would also be enhanced. In the last three years, we have been investigating student scientific and evidence-based reasoning abilities in a K-8 pre-service science course at Cal Poly Pomona. After recognizing student difficulties understanding the elements of scientific reasoning, we have provided explicit feedback using a rubric to assist students to become more rigorous and reflective thinkers; to use appropriate and accurate vocabulary; exercise evidence-base reasoning; and develop skepticism with respect to their own views. We will share the rubric and report on the preliminary results.

A Qualitative Study of Learning from CAL Programs in Two Tertiary Education Courses.

ERIC Educational Resources Information Center

McAlpine, Iain

The purpose of this paper is to consider a range of qualitative aspects and measures of student learning in current use, and to consider the insights into student learning that these provide. In this study, a measure of depth of processing, the Structure of Observed Learning Outcomes (SOLO) taxonomy developed by J. B. Biggs and F. K. Collis (1982)…

The impact of threshold language assistance programming on the accessibility of mental health services for persons with limited English proficiency in the Medi-Cal setting.

PubMed

McClellan, Sean R; Wu, Frances M; Snowden, Lonnie R

2012-06-01

Title VI of the 1964 Civil Rights Act prohibits federal funds recipients from providing care to limited English proficiency (LEP) persons more limited in scope or lower in quality than care provided to others. In 1999, the California Department of Mental Health implemented a "threshold language access policy" to meet its Title VI obligations. Under this policy, Medi-Cal agencies must provide language assistance programming in a non-English language where a county's Medical population contains either 3000 residents or 5% speakers of that language. We examine the impact of threshold language policy-required language assistance programming on LEP persons' access to mental health services by analyzing the county-level penetration rate of services for Russian, Spanish, and Vietnamese speakers across 34 California counties, over 10 years of quarterly data. Exploiting a time series with nonequivalent control group study design, we studied this phenomena using linear regression with random county effects to account for trends over time. Threshold language policy-required assistance programming led to an immediate and significant increase in the penetration rate of mental health services for Russian (8.2, P < 0.01) and Vietnamese (3.3, P < 0.01) language speaking persons. Threshold language assistance programming was effective in increasing mental health access for Russian and Vietnamese, but not for Spanish-speaking LEP persons.

Unlearning, Critical Action Learning and Wicked Problems

ERIC Educational Resources Information Center

Pedler, Mike; Hsu, Shih-wei

2014-01-01

This paper explores the idea of unlearning in Critical Action Learning (CAL) as applied to the wicked problems of organisations and societies. It draws on data and ideas developed during a research project conducted for "Skills for Care" by Pedler, Abbott, Brook and Burgoyne ("Skills for Care" 2014) and from experiences on…

Software Engineering Techniques for Computer-Aided Learning.

ERIC Educational Resources Information Center

Ibrahim, Bertrand

1989-01-01

Describes the process for developing tutorials for computer-aided learning (CAL) using a programing language rather than an authoring system. The workstation used is described, the use of graphics is discussed, the role of a local area network (LAN) is explained, and future plans are discussed. (five references) (LRW)

Biological Simulations in Distance Learning. CAL Research Group Technical Report No. 12.

ERIC Educational Resources Information Center

Murphy, P. J.

When two biological simulations on evolution and genetics (one originally developed for a conventional university undergraduate course) were introduced into Open University distance education classes, the difficulties encountered required a reappraisal of the concept of using computer simulation for distance learning and decisions on which…

Army Leader Transitions Handbook

DTIC Science & Technology

2008-01-01

The courseware allows users to tailor training materials to specific needs. Users access this at the CAL AKO website or Army eLearning https...Priorities PHASE III: INITIAL ASSESSMENT (D+1 to D+30) Step 1: Expedite Learning to Assess the Organization and Your Subordinates Step 2: Build...so respect that relationship/position. Learn as much as possible without inter- fering in current affairs. Establishing a good dialogue with the

"Horses for Courses": Categories of Computer-Based Learning Program and Their Uses in Pharmacology Courses.

ERIC Educational Resources Information Center

Hughes, Ian E.

1998-01-01

Describes the pharma-CAL-ogy project, funded by Teaching and Learning Technology Programme (TLTP), which has developed various types of software for use in pharmacology courses. Topics include course organization and delivery software, drill and practice software, tutorial-type programs, simulations, and the need to integrate computer-assisted…

Initial impressions from the Northern California 2008 lightning siege: A report by a Wildland Fire Lessons Learned Center Information Collection Team

Treesearch

Jonetta T. Holt; David Christenson; Anne Black; Brett Fay; Kim Round

2009-01-01

This event in NorCal is another of the major events we have experienced in fire management. In line with our desire to learn, we ought to line up a team to help us capture lessons learned from this event." This statement, and a regional delegation, was the impetus for an information collection team from the Wildland Fire Lessons Learned Center to visit with...

Career Pathways Partnerships. K-12 & Afterschool Policy Brief

ERIC Educational Resources Information Center

Children Now, 2010

2010-01-01

On June 30, 2010, California awarded $3 million to support teacher recruitment and training through the California Gang Reduction, Intervention and Prevention (CalGRIP) initiative, which assists young adults at risk of joining gangs in finding employment or pursuing an education. California chose to fund six Career Pathways Partnership projects as…

A School Where Learning Is Personal

ERIC Educational Resources Information Center

Rickabaugh, Jim; Sprader, Christina; Murray, James

2017-01-01

To create a clear picture of a personalized learning environment, this article walks us through a day at the Waukesha STEM Academy, a Wisconsin charter school serving about 300 students in grades 6-8. The article follows Cal, a student making the transition from his former traditional school (where every week looked about the same) to a school…

Technical Feasibility of a Mobile Context-Aware (Social) Learning Schedule Framework

ERIC Educational Resources Information Center

Yau, Jane Y. K.; Joy, Mike

2013-01-01

The purpose of this paper is to show the technical feasibility of implementing their mobile context-aware learning schedule (mCALS) framework as a software application on a mobile device using current technologies, prior to its actual implementation. This process draws a set of compatible mobile and context-aware technologies at present and can be…

The Cal-Bridge Program: Increasing the Gender and Ethnic Diversity of Astrophysics Students in Southern California

NASA Astrophysics Data System (ADS)

Smecker-Hane, Tammy A.; Rudolph, Alexander L.

2016-06-01

The mission of the Cal-Bridge program is to increase the number of underrepresented minority and women students completing a bachelor’s degree and entering a PhD program in astronomy, physics, or closely-related fields. The program has created a network of faculty at diverse higher education institutions, including 5 University of California (UC) campuses, 9 California State Universities (CSUs), and 10 community colleges in southern California, dedicated to this goal. Students selected for the program are know as “Cal-Bridge Scholars” and they are given a wide variety of support: (1) scholarships in their junior/senior years at CSU and their first year of graduate school at a UC, (2) intensive mentoring by a pair of CSU and UC faculty members, (3) tutoring, when needed, (4) professional development workshops, (5) exposure to research opportunities at various universities, and (6) membership in a growing cohort of like-minded students. We report on the structure of our program, lessons learned with our current 12 Cal-Bridge scholars, and the results of our first two years of operation. Funding for this program is provided by NSF-SSTEM Grant #1356133.

How In-Service Teachers Develop Electronic Lessons

ERIC Educational Resources Information Center

Zsoldos-Marchis, Iuliana

2014-01-01

Computer assisted teaching (CAL) is considered to be a modern teaching method, but it is not widely used by teachers because lack of technology and adequate educational softwares in schools; or lack of teachers' knowledge on methodology and computer use. In order to select the most efficient educational software for their class, teachers should…

Do we need dissection in an integrated problem-based learning medical course? Perceptions of first- and second-year students.

PubMed

Azer, Samy A; Eizenberg, Norm

2007-03-01

The introduction of a problem-based learning (PBL) curriculum at the School of Medicine of the University of Melbourne has necessitated a reduction in the number of lectures and limited the use of dissection in teaching anatomy. In the new curriculum, students learn the anatomy of different body systems using PBL tutorials, practical classes, pre-dissected specimens, computer-aided learning multimedia and a few dissection classes. The aims of this study are: (1) to assess the views of first- and second-year medical students on the importance of dissection in learning about the anatomy, (2) to assess if students' views have been affected by demographic variables such as gender, academic background and being a local or an international student, and (3) to assess which educational tools helped them most in learning the anatomy and whether dissection sessions have helped them in better understanding anatomy. First- and second-year students enrolled in the medical course participated in this study. Students were asked to fill out a 5-point Likert scale questionnaire. Data was analysed using Mann-Whitney's U test, Wilcoxon's signed-ranks or the calculation of the Chi-square value. The response rates were 89% for both first- and second-year students. Compared to second-year students, first-year students perceived dissection to be important for deep understanding of anatomy (P < 0.001), making learning interesting (P < 0.001) and introducing them to emergency procedures (P < 0.001). Further, they preferred dissection over any other approach (P < 0.001). First-year students ranked dissection (44%), textbooks (23%), computer-aided learning (CAL), multimedia (10%), self-directed learning (6%) and lectures (5%) as the most valuable resources for learning anatomy, whereas second-year students found textbooks (38%), dissection (18%), pre-dissected specimens (11%), self-directed learning (9%), lectures (7%) and CAL programs (7%) as most useful. Neither of the groups showed a significant preference for pre-dissected specimens, CAL multimedia or lectures over dissection. Both first- and second-year students, regardless of their gender, academic background, or citizenship felt that the time devoted to dissection classes were not adequate. Students agreed that dissection deepened their understanding of anatomical structures, provided them with a three-dimensional perspective of structures and helped them recall what they learnt. Although their perception about the importance of dissection changed as they progressed in the course, good anatomy textbooks were perceived as an excellent resource for learning anatomy. Interestingly, innovations used in teaching anatomy, such as interactive multimedia resources, have not replaced students' perceptions about the importance of dissection.

Last glacial maximum and Holocene lake levels of Owens Lake, eastern California, USA

USGS Publications Warehouse

Bacon, S.N.; Burke, R.M.; Pezzopane, S.K.; Jayko, A.S.

2006-01-01

Stratigraphic investigations of fluvio-deltaic and lacustrine sediments exposed in stream cuts, quarry walls, and deep trenches east of the Sierra Nevada in Owens Valley near Lone Pine, California have enabled the reconstruction of pluvial Owens Lake level oscillations. Age control for these sediments is from 22 radiocarbon (14C) dates and the identification and stratigraphic correlation of a tephra, which when plotted as a function of age versus altitude, define numerous oscillations in the level of pluvial Owens Lake during the latest Pleistocene and early Holocene. We have constructed a lake-level altitude curve for the time interval ???27,000 cal yr BP to present that is based on the integration of this new stratigraphic analysis with published surface stratigraphic data and subsurface core data. Pluvial Owens Lake regressed from its latest Pleistocene highstands from ???27,000 to ???15,300 cal yr BP, as recorded by ???15 m of down cutting of the sill from the altitudes of ???1160 to 1145 m. By ???11,600 cal yr BP, the lake had dropped ???45 m from the 1145 m sill. This lowstand was followed by an early Holocene transgression that attained a highstand near 1135 m before dropping to 1120 m at 7860-7650 cal yr BP that had not been recognized in earlier studies. The lake then lowered another ???30 m to shallow and near desiccation levels between ???6850 and 4300 cal yr BP. Fluvial cut-and-fill relations north of Lone Pine and well-preserved shoreline features at ???1108 m indicate a minor lake-level rise after 4300 cal yr BP, followed by alkaline and shallow conditions during the latest Holocene. The new latest Quaternary lake-level record of pluvial Owens Lake offers insight to the hydrologic balance along the east side of the southern Sierra Nevada and will assist regional paleoclimatic models for the western Basin and Range. ?? 2005 Elsevier Ltd. All rights reserved.

Case Studies in CAL!

ERIC Educational Resources Information Center

Rogers, David F., Ed.; Smith, P. R., Ed.

1984-01-01

Ten papers focus on applications in specific curriculum areas, modelling and simulation, and computer managed learning. Projects described include voice support for the visually handicapped, distance education, and industrial training, as well as teaching applied mathematics, several facets of engineering, zoology, and, with videodisc, observation…

ICCE/ICCAI 2000 Full & Short Papers (Virtual Reality in Education).

ERIC Educational Resources Information Center

2000

This document contains the full text of the following full and short papers on virtual reality in education from ICCE/ICCAI 2000 (International Conference on Computers in Education/International Conference on Computer-Assisted Instruction): (1) "A CAL System for Appreciation of 3D Shapes by Surface Development (C3D-SD)" (Stephen C. F. Chan, Andy…

Calibration and performance of the ATLAS Tile Calorimeter during the LHC Run 2

NASA Astrophysics Data System (ADS)

Cerda Alberich, L.

2018-02-01

The Tile Calorimeter (TileCal) is the hadronic sampling calorimeter of the ATLAS experiment at the Large Hadron Collider (LHC). TileCal uses iron absorbers and scintillators as active material and it covers the central region | η| < 1.7. Jointly with the other sub-detectors it is designed for measurements of hadrons, jets, tau-particles and missing transverse energy. It also assists in muon identification. TileCal is regularly monitored and calibrated by several different calibration systems: a Cs radioactive source, a laser light system to check the PMT response, and a charge injection system (CIS) to check the front-end electronics. These calibration systems, in conjunction with data collected during proton-proton collisions, Minimum Bias (MB) events, provide extensive monitoring of the instrument and a means for equalizing the calorimeter response at each stage of the signal propagation. The performance of the calorimeter has been established with cosmic ray muons and the large sample of the proton-proton collisions and compared to Monte Carlo (MC) simulations. The response of high momentum isolated muons is also used to study the energy response at the electromagnetic scale, isolated hadrons are used as a probe of the hadronic response. The calorimeter time resolution is studied with multijet events. A description of the different TileCal calibration systems and the results on the calorimeter performance during the LHC Run 2 are presented. The results on the pile-up noise and response uniformity studies are also discussed.

[Papers of the ELF Project].

ERIC Educational Resources Information Center

Barker, Philip; And Others

The five papers in this collection discuss various aspects of the Electronic Learning-Package Factory (ELF) project at the University of Bradford in England. In the first paper, "Adoption of CAL in Higher Education: A Cooperative Approach to Research, Development and Implementation," Philip Barker considers the opportunities for…

The Comprehension Approach to Foreign Language Instruction.

ERIC Educational Resources Information Center

Winitz, Harris, Ed.

The comprehension approach to second language education emphasizes acquisition of listening comprehension prior to and as a vehicle for acquisition of other language skills. The following articles on this approach are collected here: (1) "Nonlinear Learning and Language Teaching" (Winitz); (2) "Aital cal aprene las lengas…

The Somalis: Their History and Culture. CAL Refugee Fact Sheet Series, No. 9.

ERIC Educational Resources Information Center

Putman, Diana Briton; Noor, Mohamood Cabdi

This booklet is a basic introduction to the people, history, and culture of Somalia. It is designed primarily for service providers and others assisting Somali refugees in their new communities in the United States. Somalis have a long tradition of going abroad to work or study, and today, about 1 million Somalis live scattered around the world.…

Analysis of the Interactions between Treaties

DTIC Science & Technology

1992-04-01

PROVISIONS Assist ana protect against chemical weapons UIVERSALITY Research, share/exchange chemi- cals, equipment, information rela. Not applicable ting...liability in the event of injury to a Soviet inspector. U.S. escorts maintain the right to prevent Soviet inspectors from undertaking life ...updated continually through notifications for the life of the Treaty and in total at periodic intervals. The START Treaty requires a myriad of

Evolutionary history of callose synthases in terrestrial plants with emphasis on proteins involved in male gametophyte development

PubMed Central

Honys, David

2017-01-01

Callose is a plant-specific polysaccharide (β-1,3-glucan) playing an important role in angiosperms in many developmental processes and responses to biotic and abiotic stresses. Callose is synthesised at the plasma membrane of plant cells by callose synthase (CalS) and, among others, represents the main polysaccharide in the callose wall surrounding the tetrads of developing microspores and in the growing pollen tube wall. CalS proteins involvement in spore development is a plesiomorphic feature of terrestrial plants, but very little is known about their evolutionary origin and relationships amongst the members of this protein family. We performed thorough comparative analyses of callose synthase family proteins from major plant lineages to determine their evolutionary history across the plant kingdom. A total of 1211 candidate CalS sequences were identified and compared amongst diverse taxonomic groups of plants, from bryophytes to angiosperms. Phylogenetic analyses identified six main clades of CalS proteins and suggested duplications during the evolution of specialised functions. Twelve family members had previously been identified in Arabidopsis thaliana. We focused on five CalS subfamilies directly linked to pollen function and found that proteins expressed in pollen evolved twice. CalS9/10 and CalS11/12 formed well-defined clades, whereas pollen-specific CalS5 was found within subfamilies that mostly did not express in mature pollen vegetative cell, although were found in sperm cells. Expression of five out of seven mature pollen-expressed CalS genes was affected by mutations in bzip transcription factors. Only three subfamilies, CalS5, CalS10, and CalS11, however, formed monophyletic, mostly conserved clades. The pairs CalS9/CalS10, CalS11/CalS12 and CalS3 may have diverged after angiosperms diversified from lycophytes and bryophytes. Our analysis of fully sequenced plant proteins identified new evolutionary lineages of callose synthase subfamilies and has established a basis for understanding their functional evolution in terrestrial plants. PMID:29131847

Final Report Feasibility Study for the California Wave Energy Test Center (CalWavesm)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blakeslee, Samuel Norman; Toman, William I.; Williams, Richard B.

The California Wave Energy Test Center (CalWave) Feasibility Study project was funded over multiple phases by the Department of Energy to perform an interdisciplinary feasibility assessment to analyze the engineering, permitting, and stakeholder requirements to establish an open water, fully energetic, grid connected, wave energy test center off the coast of California for the purposes of advancing U.S. wave energy research, development, and testing capabilities. Work under this grant included wave energy resource characterization, grid impact and interconnection requirements, port infrastructure and maritime industry capability/suitability to accommodate the industry at research, demonstration and commercial scale, and macro and micro sitingmore » considerations. CalWave Phase I performed a macro-siting and down-selection process focusing on two potential test sites in California: Humboldt Bay and Vandenberg Air Force Base. This work resulted in the Vandenberg Air Force Base site being chosen as the most favorable site based on a peer reviewed criteria matrix. CalWave Phase II focused on four siting location alternatives along the Vandenberg Air Force Base coastline and culminated with a final siting down-selection. Key outcomes from this work include completion of preliminary engineering and systems integration work, a robust turnkey cost estimate, shoreside and subsea hazards assessment, storm wave analysis, lessons learned reports from several maritime disciplines, test center benchmarking as compared to existing international test sites, analysis of existing applicable environmental literature, the completion of a preliminary regulatory, permitting and licensing roadmap, robust interaction and engagement with state and federal regulatory agency personnel and local stakeholders, and the population of a Draft Federal Energy Regulatory Commission (FERC) Preliminary Application Document (PAD). Analysis of existing offshore oil and gas infrastructure was also performed to assess the potential value and re-use scenarios of offshore platform infrastructure and associated subsea power cables and shoreside substations. The CalWave project team was well balanced and was comprised of experts from industry, academia, state and federal regulatory agencies. The result of the CalWave feasibility study finds that the CalWave Test Center has the potential to provide the most viable path to commercialization for wave energy in the United States.« less

Developmental evolution of flowering plant pollen tube cell walls: callose synthase (CalS) gene expression patterns

PubMed Central

2011-01-01

Background A number of innovations underlie the origin of rapid reproductive cycles in angiosperms. A critical early step involved the modification of an ancestrally short and slow-growing pollen tube for faster and longer distance transport of sperm to egg. Associated with this shift are the predominantly callose (1,3-β-glucan) walls and septae (callose plugs) of angiosperm pollen tubes. Callose synthesis is mediated by callose synthase (CalS). Of 12 CalS gene family members in Arabidopsis, only one (CalS5) has been directly linked to pollen tube callose. CalS5 orthologues are present in several monocot and eudicot genomes, but little is known about the evolutionary origin of CalS5 or what its ancestral function may have been. Results We investigated expression of CalS in pollen and pollen tubes of selected non-flowering seed plants (gymnosperms) and angiosperms within lineages that diverged below the monocot/eudicot node. First, we determined the nearly full length coding sequence of a CalS5 orthologue from Cabomba caroliniana (CcCalS5) (Nymphaeales). Semi-quantitative RT-PCR demonstrated low CcCalS5 expression within several vegetative tissues, but strong expression in mature pollen. CalS transcripts were detected in pollen tubes of several species within Nymphaeales and Austrobaileyales, and comparative analyses with a phylogenetically diverse group of sequenced genomes indicated homology to CalS5. We also report in silico evidence of a putative CalS5 orthologue from Amborella. Among gymnosperms, CalS5 transcripts were recovered from germinating pollen of Gnetum and Ginkgo, but a novel CalS paralog was instead amplified from germinating pollen of Pinus taeda. Conclusion The finding that CalS5 is the predominant callose synthase in pollen tubes of both early-diverging and model system angiosperms is an indicator of the homology of their novel callosic pollen tube walls and callose plugs. The data suggest that CalS5 had transient expression and pollen-specific functions in early seed plants and was then recruited to novel expression patterns and functions within pollen tube walls in an ancestor of extant angiosperms. PMID:21722365

Effect of compressive stress on stability of N-doped p-type ZnO

NASA Astrophysics Data System (ADS)

Chen, Xingyou; Zhang, Zhenzhong; Yao, Bin; Jiang, Mingming; Wang, Shuangpeng; Li, Binghui; Shan, Chongxin; Liu, Lei; Zhao, Dongxu; Shen, Dezhen

2011-08-01

Nitrogen-doped p-type zinc oxide (p-ZnO:N) thin films were fabricated on a-/c-plane sapphire (a-/c-Al2O3) by plasma-assisted molecular beam epitaxy. Hall-effect measurements show that the p-type ZnO:N on c-Al2O3 degenerated into n-type after a preservation time; however, the one grown on a-Al2O3 showed good stability. The conversion of conductivity in the one grown on c-Al2O3 ascribed to the faster disappearance of NO and the growing N2(O), which is demonstrated by x-ray photoelectron spectroscopy (XPS). Compressive stress, caused by lattice misfit, was revealed by Raman spectra and optical absorption spectra, and it was regarded as the root of the instability in ZnO:N.

Computer literacy among first year medical students in a developing country: a cross sectional study.

PubMed

Ranasinghe, Priyanga; Wickramasinghe, Sashimali A; Pieris, Wa Rasanga; Karunathilake, Indika; Constantine, Godwin R

2012-09-14

The use of computer assisted learning (CAL) has enhanced undergraduate medical education. CAL improves performance at examinations, develops problem solving skills and increases student satisfaction. The study evaluates computer literacy among first year medical students in Sri Lanka. The study was conducted at Faculty of Medicine, University of Colombo, Sri Lanka between August-September 2008. First year medical students (n = 190) were invited for the study. Data on computer literacy and associated factors were collected by an expert-validated pre-tested self-administered questionnaire. Computer literacy was evaluated by testing knowledge on 6 domains; common software packages, operating systems, database management and the usage of internet and E-mail. A linear regression was conducted using total score for computer literacy as the continuous dependant variable and other independent covariates. Sample size-181 (Response rate-95.3%), 49.7% were Males. Majority of the students (77.3%) owned a computer (Males-74.4%, Females-80.2%). Students have gained their present computer knowledge by; a formal training programme (64.1%), self learning (63.0%) or by peer learning (49.2%). The students used computers for predominately; word processing (95.6%), entertainment (95.0%), web browsing (80.1%) and preparing presentations (76.8%). Majority of the students (75.7%) expressed their willingness for a formal computer training programme at the faculty.Mean score for the computer literacy questionnaire was 48.4 ± 20.3, with no significant gender difference (Males-47.8 ± 21.1, Females-48.9 ± 19.6). There were 47.9% students that had a score less than 50% for the computer literacy questionnaire. Students from Colombo district, Western Province and Student owning a computer had a significantly higher mean score in comparison to other students (p < 0.001). In the linear regression analysis, formal computer training was the strongest predictor of computer literacy (β = 13.034), followed by using internet facility, being from Western province, using computers for Web browsing and computer programming, computer ownership and doing IT (Information Technology) as a subject in GCE (A/L) examination. Sri Lankan medical undergraduates had a low-intermediate level of computer literacy. There is a need to improve computer literacy, by increasing computer training in schools, or by introducing computer training in the initial stages of the undergraduate programme. These two options require improvement in infrastructure and other resources.

What Will It Take To Ensure Implementation? A Content Literacy Dilemma.

ERIC Educational Resources Information Center

Rafferty, Cathleen D.

A study attempted to determine a variety of facilitating and militating elements that influence Content Area Literacy/Learning Teaching Strategies (CAL/LTS) implementation. It investigated the impact of various contextual or ecological features embedded within the student teaching experience on student teachers' ability to implement various…

Evaluating the Effectiveness of E-Learning in Teacher Preparation

ERIC Educational Resources Information Center

Chiero, Robin; Beare, Paul; Marshall, James; Torgerson, Colleen

2015-01-01

Teacher education struggles with the challenge of preparing and retaining high-quality teachers who can work effectively with all students. While educator preparation is a strong correlate of student achievement, traditional university-based programmes are not available to all potential teachers. This manuscript describes CalStateTEACH, an online…

Hybrid Optical Inference Machines

DTIC Science & Technology

1991-09-27

with labels. Now, events. a set of facts cal be generated in the dyadic form "u, R 1,2" Eichmann and Caulfield (19] consider the same type of and can...these enceding-schemes. These architectures are-based pri- 19. G. Eichmann and H. J. Caulfield, "Optical Learning (Inference)marily on optical inner

Centre for Applied Language Studies, University of Limerick, Ireland

ERIC Educational Resources Information Center

Chambers, Angela; Atkinson, David; Farr, Fiona

2015-01-01

The Centre for Applied Language Studies (CALS), founded in 1997, brings together researchers and postgraduate students from several disciplines in language studies, and is structured in three research clusters: New learning environments; Discourse, society and identity; and Plurilingualism and language policy. There is a certain amount of…

How Can Intelligent CAL Better Adapt to Learners?

ERIC Educational Resources Information Center

Boyd, Gary McI.; Mitchell, P. David

1992-01-01

Discusses intelligent computer-aided learning (ICAL) support systems and considers learner characteristics as elements of ICAL student models. Cybernetic theory and attribute-treatment results are discussed, six components of a student model for tutoring are described, and methods for determining the student's model of the tutor are examined. (22…

Dominie: Teaching and Assessment Strategies. CAL Research Group Technical Report No. 74.

ERIC Educational Resources Information Center

Spensley, Fiona; Elsom-Cook, Mark

This document outlines the strategies that are used for teaching and assessment in Dominie, an intelligent tutoring system designed to enable the user to operate a computer interface independently. Eight interaction modes are described in detail: four teaching strategies (cognitive apprenticeship, successive refinement, discovery learning, and…

The attitudes of undergraduate students and staff to the use of electronic learning.

PubMed

Gupta, B; White, D A; Walmsley, A D

2004-04-24

Computer-aided learning (CAL) offers advantages over traditional methods of learning as it allows students to work in their own time and pace. The School of Dentistry at the University of Birmingham has created an electronic learning website, named the Ecourse. This is designed to be a web-based supplement to the dental undergraduate curriculum. The aim of this study was to determine the attitudes of third year dental students and members of staff about the Ecourse website. A questionnaire was produced and piloted before being distributed to all 65 third year dental students to obtain their opinions about the Ecourse website. The views of Ecourse were sought from four members of staff by performing qualitative, semi-structured interviews. Lecture handouts and textbooks were reported as the sources used most often, by 96% of students. Eighty-six per cent of students are accessing the Ecourse mainly at the School of Dentistry, but 53% are also accessing it at home. Students liked the multiple-choice questions, downloading extra notes and looking at pictures and animation to explain clinical procedures. The majority of the students (79%) want the Ecourse to be used as a supplement to the undergraduate programme and 7% wanted it to replace formal lectures. Staff recognised the benefits of the Ecourse but were concerned about plagiarism, the effect on lecture attendance and the lack of feedback from students on existing CAL material. Students consider the Ecourse as a positive method of supplementing traditional methods of learning in the dental undergraduate programme. However in contrast teaching staff expressed negative views on the use of e-learning.

Quantum Machine Learning over Infinite Dimensions

DOE PAGES

Lau, Hoi-Kwan; Pooser, Raphael; Siopsis, George; ...

2017-02-21

Machine learning is a fascinating and exciting eld within computer science. Recently, this ex- citement has been transferred to the quantum information realm. Currently, all proposals for the quantum version of machine learning utilize the nite-dimensional substrate of discrete variables. Here we generalize quantum machine learning to the more complex, but still remarkably practi- cal, in nite-dimensional systems. We present the critical subroutines of quantum machine learning algorithms for an all-photonic continuous-variable quantum computer that achieve an exponential speedup compared to their equivalent classical counterparts. Finally, we also map out an experi- mental implementation which can be used as amore » blueprint for future photonic demonstrations.« less

Quantum Machine Learning over Infinite Dimensions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lau, Hoi-Kwan; Pooser, Raphael; Siopsis, George

Machine learning is a fascinating and exciting eld within computer science. Recently, this ex- citement has been transferred to the quantum information realm. Currently, all proposals for the quantum version of machine learning utilize the nite-dimensional substrate of discrete variables. Here we generalize quantum machine learning to the more complex, but still remarkably practi- cal, in nite-dimensional systems. We present the critical subroutines of quantum machine learning algorithms for an all-photonic continuous-variable quantum computer that achieve an exponential speedup compared to their equivalent classical counterparts. Finally, we also map out an experi- mental implementation which can be used as amore » blueprint for future photonic demonstrations.« less

Evaluation of a distance-learning immunology and pathology module in a postgraduate biomedical science course.

PubMed

Ryan, M T; Mulholland, C W

2005-01-01

An electronic presentation of materials for a distance-learning immunology and pathology module from a postgraduate biomedical science course is evaluated. Two different electronic presentation formats for the delivery of the educational material to distance learners are assessed. Responses from users of this material highlighted a preference for a format that has a design tailored to distance learning. There was no significant difference in learning outcome between those taking the module on campus and by distance learning. This suggests that the prerequisites for entry, learning materials and direction given to the students studying by distance learning are adequate for these students to achieve the learning objectives outlined in the course. The evaluation also gave direction for areas within the (CAL) application that can be improved for future students.

CAL3JHH: a Java program to calculate the vicinal coupling constants (3J H,H) of organic molecules.

PubMed

Aguirre-Valderrama, Alonso; Dobado, José A

2008-12-01

Here, we present a free web-accessible application, developed in the JAVA programming language for the calculation of vicinal coupling constant (3J(H,H)) of organic molecules with the H-Csp3-Csp3-H fragment. This JAVA applet is oriented to assist chemists in structural and conformational analyses, allowing the user to calculate the averaged 3J(H,H) values among conformers, according to its Boltzmann populations. Thus, the CAL3JHH program uses the Haasnoot-Leeuw-Altona equation, and, by reading the molecule geometry from a protein data bank (PDB) file format or from multiple pdb files, automatically detects all the coupled hydrogens, evaluating the data needed for this equation. Moreover, a "Graphical viewer" menu allows the display of the results on the 3D molecule structure, as well as the plotting of the Newman projection for the couplings.

Differential Gains in Oral Proficiency during Study Abroad: The Role of Language Learning Aptitudes

ERIC Educational Resources Information Center

Anderson, Sheri Lynn

2012-01-01

This inquiry analyzed the relationships between individual differences and gains made in oral proficiency of adult, second language learners of Spanish during one semester studying abroad. Oral proficiency was measured using a pre/post-SA Computerized Oral Proficiency Instrument (COPI, CAL, 2009). Gain scores were correlated with two cognitive…

Characteristics of Literacy Instruction That Support Reform in Content Area Classrooms

ERIC Educational Resources Information Center

Siebert, Daniel K.; Draper, Roni Jo; Barney, Daniel; Broomhead, Paul; Grierson, Sirpa; Jensen, Amy P.; Nielson, Jennifer; Nokes, Jeffery D.; Shumway, Steven; Wimmer, Jennifer

2016-01-01

Current reforms in content area education present new challenges for literacy educators. These reforms promote engaging students in the practices of the disciplines--teaching students how to participate in an activity in which disciplinary content is produced. Content area literacy (CAL) instruction that supports only the learning of general…

Teaching Engineering Students Team Work

NASA Technical Reports Server (NTRS)

Levi, Daniel

1998-01-01

The purpose of this manual is to provide professor's in engineering classes which the background necessary to use student team projects effectively. This manual describes some of the characteristics of student teams and how to use them in class. It provides a set of class activities and films which can be used to introduce and support student teams. Finally, a set of teaching modules used in freshmen, sophomore, and senior aeronautical engineering classes are presented. This manual was developed as part of a NASA sponsored project to improve the undergraduate education of aeronautical engineers. The project has helped to purchase a set of team work films which can be checked out from Cal Poly's Learning Resources Center in the Kennedy Library. Research for this project has included literature reviews on team work and cooperative learning; interviews, observations, and surveys of Cal Poly students from Industrial and Manufacturing Engineering, Aeronautical Engineering and Psychology; participation in the Aeronautical Engineering senior design lab; and interviews with engineering faculty. In addition to this faculty manual, there is a student team work manual which has been designed to help engineering students work better in teams.

Activation of pollen tube callose synthase by detergents. Evidence for different mechanisms of action.

PubMed Central

Li, H; Bacic, A; Read, S M

1997-01-01

In pollen tubes of Nicotiana alata, a membrane-bound, Ca(2+)-independent callose synthase (CalS) is responsible for the biosynthesis of the (1,3)-beta-glucan backbone of callose, the main cell wall component. Digitonin increases CalS activity 3- to 4-fold over a wide range of concentrations, increasing the maximum initial velocity without altering the Michaelis constant for UDP-glucose. The CalS activity that requires digitonin for assay (the latent CalS activity) is not inhibited by the membrane-impermeant, active site-directed reagent UDP-pyridoxal when the reaction is conducted in the absence of digitonin. This is consistent with digitonin increasing CalS activity by the permeabilization of membrane vesicles. A second group of detergents, including 3-[(3-cholamidopropyl)dimethylammonio]-1-propane-sulfonate (CHAPS), Zwittergent 3-16, and 1-alpha-lysolecithin, activate pollen tube CalS 10- to 15-fold, but only over a narrow range of concentrations just below their respective critical micellar concentrations. This activation could not be attributed to any particular chemical feature of these detergents. CHAPS increases maximum initial velocity and decreases the Michaelis constant for UDP-glucose and activates CalS even in the presence of permeabilizing concentrations of digitonin. Inhibition studies with UDP-pyridoxal indicate that activation by CHAPS occurs by recruitment of previously inactive CalS molecules to the pool of active enzyme. The activation of pollen tube CalS by these detergents therefore resembles activation of the enzyme by trypsin. PMID:9276948

Final Report Feasibility Study for the California Wave Energy Test Center (CalWavesm) - Volume #2 - Appendices #16-17

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dooher, Brendan; Toman, William I.; Davy, Doug M.

The California Wave Energy Test Center (CalWave) Feasibility Study project was funded over multiple phases by the Department of Energy to perform an interdisciplinary feasibility assessment to analyze the engineering, permitting, and stakeholder requirements to establish an open water, fully energetic, grid connected, wave energy test center off the coast of California for the purposes of advancing U.S. wave energy research, development, and testing capabilities. Work under this grant included wave energy resource characterization, grid impact and interconnection requirements, port infrastructure and maritime industry capability/suitability to accommodate the industry at research, demonstration and commercial scale, and macro and micro sitingmore » considerations. CalWave Phase I performed a macro-siting and down-selection process focusing on two potential test sites in California: Humboldt Bay and Vandenberg Air Force Base. This work resulted in the Vandenberg Air Force Base site being chosen as the most favorable site based on a peer reviewed criteria matrix. CalWave Phase II focused on four siting location alternatives along the Vandenberg Air Force Base coastline and culminated with a final siting down-selection. Key outcomes from this work include completion of preliminary engineering and systems integration work, a robust turnkey cost estimate, shoreside and subsea hazards assessment, storm wave analysis, lessons learned reports from several maritime disciplines, test center benchmarking as compared to existing international test sites, analysis of existing applicable environmental literature, the completion of a preliminary regulatory, permitting and licensing roadmap, robust interaction and engagement with state and federal regulatory agency personnel and local stakeholders, and the population of a Draft Federal Energy Regulatory Commission (FERC) Preliminary Application Document (PAD). Analysis of existing offshore oil and gas infrastructure was also performed to assess the potential value and re-use scenarios of offshore platform infrastructure and associated subsea power cables and shoreside substations. The CalWave project team was well balanced and was comprised of experts from industry, academia, state and federal regulatory agencies. The result of the CalWave feasibility study finds that the CalWave Test Center has the potential to provide the most viable path to commercialization for wave energy in the United States.« less

E-learning in medical education in resource constrained low- and middle-income countries.

PubMed

Frehywot, Seble; Vovides, Yianna; Talib, Zohray; Mikhail, Nadia; Ross, Heather; Wohltjen, Hannah; Bedada, Selam; Korhumel, Kristine; Koumare, Abdel Karim; Scott, James

2013-02-04

In the face of severe faculty shortages in resource-constrained countries, medical schools look to e-learning for improved access to medical education. This paper summarizes the literature on e-learning in low- and middle-income countries (LMIC), and presents the spectrum of tools and strategies used. Researchers reviewed literature using terms related to e-learning and pre-service education of health professionals in LMIC. Search terms were connected using the Boolean Operators "AND" and "OR" to capture all relevant article suggestions. Using standard decision criteria, reviewers narrowed the article suggestions to a final 124 relevant articles. Of the relevant articles found, most referred to e-learning in Brazil (14 articles), India (14), Egypt (10) and South Africa (10). While e-learning has been used by a variety of health workers in LMICs, the majority (58%) reported on physician training, while 24% focused on nursing, pharmacy and dentistry training. Although reasons for investing in e-learning varied, expanded access to education was at the core of e-learning implementation which included providing supplementary tools to support faculty in their teaching, expanding the pool of faculty by connecting to partner and/or community teaching sites, and sharing of digital resources for use by students. E-learning in medical education takes many forms. Blended learning approaches were the most common methodology presented (49 articles) of which computer-assisted learning (CAL) comprised the majority (45 articles). Other approaches included simulations and the use of multimedia software (20 articles), web-based learning (14 articles), and eTutor/eMentor programs (3 articles). Of the 69 articles that evaluated the effectiveness of e-learning tools, 35 studies compared outcomes between e-learning and other approaches, while 34 studies qualitatively analyzed student and faculty attitudes toward e-learning modalities. E-learning in medical education is a means to an end, rather than the end in itself. Utilizing e-learning can result in greater educational opportunities for students while simultaneously enhancing faculty effectiveness and efficiency. However, this potential of e-learning assumes a certain level of institutional readiness in human and infrastructural resources that is not always present in LMICs. Institutional readiness for e-learning adoption ensures the alignment of new tools to the educational and economic context.

E-learning in medical education in resource constrained low- and middle-income countries

PubMed Central

2013-01-01

Background In the face of severe faculty shortages in resource-constrained countries, medical schools look to e-learning for improved access to medical education. This paper summarizes the literature on e-learning in low- and middle-income countries (LMIC), and presents the spectrum of tools and strategies used. Methods Researchers reviewed literature using terms related to e-learning and pre-service education of health professionals in LMIC. Search terms were connected using the Boolean Operators “AND” and “OR” to capture all relevant article suggestions. Using standard decision criteria, reviewers narrowed the article suggestions to a final 124 relevant articles. Results Of the relevant articles found, most referred to e-learning in Brazil (14 articles), India (14), Egypt (10) and South Africa (10). While e-learning has been used by a variety of health workers in LMICs, the majority (58%) reported on physician training, while 24% focused on nursing, pharmacy and dentistry training. Although reasons for investing in e-learning varied, expanded access to education was at the core of e-learning implementation which included providing supplementary tools to support faculty in their teaching, expanding the pool of faculty by connecting to partner and/or community teaching sites, and sharing of digital resources for use by students. E-learning in medical education takes many forms. Blended learning approaches were the most common methodology presented (49 articles) of which computer-assisted learning (CAL) comprised the majority (45 articles). Other approaches included simulations and the use of multimedia software (20 articles), web-based learning (14 articles), and eTutor/eMentor programs (3 articles). Of the 69 articles that evaluated the effectiveness of e-learning tools, 35 studies compared outcomes between e-learning and other approaches, while 34 studies qualitatively analyzed student and faculty attitudes toward e-learning modalities. Conclusions E-learning in medical education is a means to an end, rather than the end in itself. Utilizing e-learning can result in greater educational opportunities for students while simultaneously enhancing faculty effectiveness and efficiency. However, this potential of e-learning assumes a certain level of institutional readiness in human and infrastructural resources that is not always present in LMICs. Institutional readiness for e-learning adoption ensures the alignment of new tools to the educational and economic context. PMID:23379467

The 3D structure and function of digestive cathepsin L-like proteinases of Tenebrio molitor larval midgut.

PubMed

Beton, Daniela; Guzzo, Cristiane R; Ribeiro, Alberto F; Farah, Chuck S; Terra, Walter R

2012-09-01

Cathepsin L-like proteinases (CAL) are major digestive proteinases in the beetle Tenebrio molitor. Procathepsin Ls 2 (pCAL2) and 3 (pCAL3) were expressed as recombinant proteins in Escherichia coli, purified and activated under acidic conditions. Immunoblot analyses of different T. molitor larval tissues demonstrated that a polyclonal antibody to pCAL3 recognized pCAL3 and cathepsin L 3 (CAL3) only in the anterior two-thirds of midgut tissue and midgut luminal contents of T. molitor larvae. Furthermore, immunocytolocalization data indicated that pCAL3 occurs in secretory vesicles and microvilli in anterior midgut. Therefore CAL3, like cathepsin L 2 (CAL2), is a digestive enzyme secreted by T. molitor anterior midgut. CAL3 hydrolyses Z-FR-MCA and Z-RR-MCA (typical cathepsin substrates), whereas CAL2 hydrolyses only Z-FR-MCA. Active site mutants (pCAL2C25S and pCAL3C26S) were constructed by replacing the catalytic cysteine with serine to prevent autocatalytic processing. Recombinant pCAL2 and pCAL3 mutants (pCAL2C25S and pCAL3C26S) were prepared, crystallized and their 3D structures determined at 1.85 and 2.1 Å, respectively. While the overall structure of these enzymes is similar to other members of the papain superfamily, structural differences in the S2 subsite explain their substrate specificities. The data also supported models for CAL trafficking to lysosomes and to secretory vesicles to be discharged into midgut contents. Copyright © 2012 Elsevier Ltd. All rights reserved.

Development of the Animal Management and Husbandry Online Placement Tool.

PubMed

Bates, Lucy; Crowther, Emma; Bell, Catriona; Kinnison, Tierney; Baillie, Sarah

2013-01-01

The workplace provides veterinary students with opportunities to develop a range of skills, making workplace learning an important part of veterinary education in many countries. Good preparation for work placements is vital to maximize learning; to this end, our group has developed a series of three computer-aided learning (CAL) packages to support students. The third of this series is the Animal Management and Husbandry Online Placement Tool (AMH OPT). Students need a sound knowledge of animal husbandry and the ability to handle the common domestic species. However, teaching these skills at university is not always practical and requires considerable resources. In the UK, the Royal College of Veterinary Surgeons (RCVS) requires students to complete 12 weeks of pre-clinical animal management and husbandry work placements or extramural studies (EMS). The aims are for students to improve their animal handling skills and awareness of husbandry systems, develop communication skills, and understand their future clients' needs. The AMH OPT is divided into several sections: Preparation, What to Expect, Working with People, Professionalism, Tips, and Frequently Asked Questions. Three stakeholder groups (university EMS coordinators, placement providers, and students) were consulted initially to guide the content and design and later to evaluate previews. Feedback from stakeholders was used in an iterative design process, resulting in a program that aims to facilitate student preparation, optimize the learning opportunities, and improve the experience for both students and placement providers. The CAL is available online and is open-access worldwide to support students during veterinary school.

Adolescent Literacy Practices and Positive Youth Development through Fink's Taxonomy of Significant Learning

ERIC Educational Resources Information Center

Taylor-Greathouse, Paula

2013-01-01

The purpose of this study was not to disprove the effects of the current, common remedial literacy course design and the literacy practices within that help adolescent RLLs pass statewide assessment tests, but to describe the potential long-term impact of an innovative comprehensive approach to literacy (CAL) framed through an integrated course…

Virtual Worlds and Social and Educational Inclusion: Case Study at Secondary Education Institute Cal Gravat

ERIC Educational Resources Information Center

Castañeda Quintero, Linda; Román García, María del Mar; Barlam Aspasch, Ramón

2015-01-01

This article presents a case study with the goal of becoming familiar with and understanding the incorporation of one virtual learning world--Espurnik--in a curricular diversification classroom with students in a situation of educational exclusion or academic failure. This investigation was carried out from an interpretive paradigm with a…

The Effectiveness of Mentoring for Adolescent Mothers and Their Infants: A Comparative Study between Sister Friend and Cal Learn.

ERIC Educational Resources Information Center

Tebb, Kathleen P.

This study evaluated Sister Friend, a mentoring program in Yolo County, California, serving low-income adolescent mothers and their infants. The primary objective was to determine if participating in the Sister Friend program improved the adolescent mother's parenting class attendance, the home environment, parenting behavior, and child…

Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO-ABLE study.

PubMed

Paul, C; Stein Gold, L; Cambazard, F; Kalb, R E; Lowson, D; Bang, B; Griffiths, C E M

2017-01-01

Fixed combination calcipotriol 50 μg/g (Cal) plus betamethasone 0.5 mg/g (BD) foam has been developed as a new treatment option for patients with psoriasis. The randomized, parallel-group, investigator-blinded Phase III, 12-week PSO-ABLE study compared the efficacy and safety of Cal/BD foam with Cal/BD gel. Patients aged ≥18 years with mild-to-severe psoriasis were randomized 4:4:1:1 to once-daily Cal/BD foam, Cal/BD gel, foam vehicle or gel vehicle (NCT02132936). The primary efficacy endpoint was the proportion of patients who were clear/almost clear with a ≥ 2 grade improvement according to the physician's global assessment of disease severity (i.e. treatment success) at week 4 for Cal/BD foam vs. week 8 for Cal/BD gel. Secondary efficacy endpoints included: proportion of patients achieving at least a 75% reduction in modified psoriasis area and severity index (mPASI75), and time to treatment success (TTTS). Safety was monitored throughout. A total of 463 patients were randomized: Cal/BD foam (n = 185), Cal/BD gel (n = 188), foam vehicle (n = 47), gel vehicle (n = 43); overall completion rate was 90%. Cal/BD foam achieved higher treatment success rates (38% vs. 22%; P < 0.001) and mPASI75 (52% vs. 35%; P < 0.001) by week 4 than Cal/BD gel by week 8. Median TTTS with Cal/BD foam was 6 weeks; this could not be determined for Cal/BD gel as 50% treatment success was not achieved (P < 0.001). Adverse drug reactions were reported in 14 (7.6%) Cal/BD aerosol foam patients and 7 (3.7%) Cal/BD gel patients; all were single events except for itch with Cal/BD aerosol foam (n = 5; 2.7%) and worsening psoriasis with Cal/BD gel (n = 3; 1.6%). Cal/BD aerosol foam showed significantly greater efficacy after 4 weeks, than 8 weeks of treatment with Cal/BD gel, with similar tolerability. © 2016 European Academy of Dermatology and Venereology.

Great earthquakes of variable magnitude at the Cascadia subduction zone

USGS Publications Warehouse

Nelson, A.R.; Kelsey, H.M.; Witter, R.C.

2006-01-01

Comparison of histories of great earthquakes and accompanying tsunamis at eight coastal sites suggests plate-boundary ruptures of varying length, implying great earthquakes of variable magnitude at the Cascadia subduction zone. Inference of rupture length relies on degree of overlap on radiocarbon age ranges for earthquakes and tsunamis, and relative amounts of coseismic subsidence and heights of tsunamis. Written records of a tsunami in Japan provide the most conclusive evidence for rupture of much of the plate boundary during the earthquake of 26 January 1700. Cascadia stratigraphic evidence dating from about 1600??cal yr B.P., similar to that for the 1700 earthquake, implies a similarly long rupture with substantial subsidence and a high tsunami. Correlations are consistent with other long ruptures about 1350??cal yr B.P., 2500??cal yr B.P., 3400??cal yr B.P., 3800??cal yr B.P., 4400??cal yr B.P., and 4900??cal yr B.P. A rupture about 700-1100??cal yr B.P. was limited to the northern and central parts of the subduction zone, and a northern rupture about 2900??cal yr B.P. may have been similarly limited. Times of probable short ruptures in southern Cascadia include about 1100??cal yr B.P., 1700??cal yr B.P., 3200??cal yr B.P., 4200??cal yr B.P., 4600??cal yr B.P., and 4700??cal yr B.P. Rupture patterns suggest that the plate boundary in northern Cascadia usually breaks in long ruptures during the greatest earthquakes. Ruptures in southernmost Cascadia vary in length and recurrence intervals more than ruptures in northern Cascadia.

Computer literacy among first year medical students in a developing country: A cross sectional study

PubMed Central

2012-01-01

Background The use of computer assisted learning (CAL) has enhanced undergraduate medical education. CAL improves performance at examinations, develops problem solving skills and increases student satisfaction. The study evaluates computer literacy among first year medical students in Sri Lanka. Methods The study was conducted at Faculty of Medicine, University of Colombo, Sri Lanka between August-September 2008. First year medical students (n = 190) were invited for the study. Data on computer literacy and associated factors were collected by an expert-validated pre-tested self-administered questionnaire. Computer literacy was evaluated by testing knowledge on 6 domains; common software packages, operating systems, database management and the usage of internet and E-mail. A linear regression was conducted using total score for computer literacy as the continuous dependant variable and other independent covariates. Results Sample size-181 (Response rate-95.3%), 49.7% were Males. Majority of the students (77.3%) owned a computer (Males-74.4%, Females-80.2%). Students have gained their present computer knowledge by; a formal training programme (64.1%), self learning (63.0%) or by peer learning (49.2%). The students used computers for predominately; word processing (95.6%), entertainment (95.0%), web browsing (80.1%) and preparing presentations (76.8%). Majority of the students (75.7%) expressed their willingness for a formal computer training programme at the faculty. Mean score for the computer literacy questionnaire was 48.4 ± 20.3, with no significant gender difference (Males-47.8 ± 21.1, Females-48.9 ± 19.6). There were 47.9% students that had a score less than 50% for the computer literacy questionnaire. Students from Colombo district, Western Province and Student owning a computer had a significantly higher mean score in comparison to other students (p < 0.001). In the linear regression analysis, formal computer training was the strongest predictor of computer literacy (β = 13.034), followed by using internet facility, being from Western province, using computers for Web browsing and computer programming, computer ownership and doing IT (Information Technology) as a subject in GCE (A/L) examination. Conclusion Sri Lankan medical undergraduates had a low-intermediate level of computer literacy. There is a need to improve computer literacy, by increasing computer training in schools, or by introducing computer training in the initial stages of the undergraduate programme. These two options require improvement in infrastructure and other resources. PMID:22980096

Development and evaluation of a stand-alone web-based CAL program. A case study.

PubMed

Perryer, G; Walmsley, A D; Barclay, C W; Shaw, L; Smith, A J

2000-08-01

The use of web browser technology allows the construction of computer-aided learning programs which will have a familiar interface to dentists. This paper reports on the evaluation of a web-based CAL program which covered the topic of tooth wear with an emphasis on the rôle of erosion in its aetiology. Evaluation of the software was made by 50 dentists contacted by an electronic mailing list. They completed a questionnaire which evaluated aspects of the functionality of the program educational objectives. The average age of the dentists was 39 years (range 24-70) and 82% were male. The average time of use was 1 h 10 min (range 15 min to 3 h). A significant change in their knowledge of tooth wear before and after using the program was recorded. Both the use of patient cases and leaflets scored highly with other aspects such as treatment planning and patient advice receiving high marks. All dentists commented that they had gained greater knowledge with particular reference to treatment and advice of tooth wear problems. 34 dentists (68%) found the web interface easy to use. Negative comments were mainly attributed to the quality of the pictures (4/50) which were corrected in the final release version. Respondents were asked to compare the program to other educational media on the same subject. 80% rated this CAL program as better than video, and 14% claimed it was as good as video. 84% rated it better than books, and 14% said it was as good as books. 98% preferred it to audio tapes and 86% preferred it to journals. The average amount that they would pay for a CAL package such as "tooth wear" would be 42 ECU. It is concluded that web browser software is a suitable medium for the use of a CAL program and this is reflected in its ease of use by dentists.

Effective methods of teaching and learning in anatomy as a basic science: A BEME systematic review: BEME guide no. 44.

PubMed

Losco, C Dominique; Grant, William D; Armson, Anthony; Meyer, Amanda J; Walker, Bruce F

2017-03-01

Anatomy is a subject essential to medical practice, yet time committed to teaching is on the decline, and resources required to teach anatomy is costly, particularly dissection. Advances in technology are a potential solution to the problem, while maintaining the quality of teaching required for eventual clinical application. To identify methods used to teach anatomy, including those demonstrated to enhance knowledge acquisition and retention. PubMed, CINAHL, ERIC, Academic OneFile, ProQuest, SAGE journals and Scopus were search from the earliest entry of each database to 31 August 2015. All included articles were assessed for methodological quality and low quality articles were excluded from the study. Studies were evaluated by assessment scores, qualitative outcomes where included as well as a modified Kirkpatrick model. A total of 17,820 articles were initially identified, with 29 included in the review. The review found a wide variety of teaching interventions represented in the range of studies, with CAI/CAL studies predominating in terms of teaching interventions, followed by simulation. In addition to this, CAI/CAL and simulation studies demonstrated better results overall compared to traditional teaching methods and there is evidence to support CAI/CAL as a partial replacement for dissection or a valuable tool in conjunction with dissection. This review provides evidence in support of the use of alternatives to traditional teaching methods in anatomy, in particular, the use of CAI/CAL with a number of high quality, low risk of bias studies supporting this.

Developments in Computer Aided Software Maintenance

DTIC Science & Technology

1974-09-01

thinks in terms of one sub- division until one happens to move to another one. Another study ( Tulving & Pearlstone , 1966) showed that failure to...them directions. (Wortman & Greenberg, 1971; Tulving & Pearlstone , 1966) In either case, hierarchical category formation is an economi- cal...1969.) Tulving , E., and Pearlstone , Z. "Availability Versus Accessibility of Information in Memory for Words." Journal of Verbal Learning and

The Dynamics of Learning and the Emergence of Distributed Adaption

DTIC Science & Technology

2006-05-01

regular access to experts in a wide range of disciplines—such as, biology, economics, cognitive science, and sociology—that historically have...organized a successful workshop on “Collective Cognition : Mathemati- cal Foundations of Distributed Intelligence,” bringing together workers in...processing and cognition . (For a complete list of participants, talk titles and abstracts, and other information on the workshop, see http

Design Principles and First Educational Experiments of pR, a Platform to Infer Geo-Referenced Itineraries from Travel Stories

ERIC Educational Resources Information Center

Loustau, Pierre; Nodenot, Thierry; Gaio, Mauro

2009-01-01

Purpose: The purpose of this paper is to present a computational approach and a toolset to infer spatial displacements as they occur in route narrative documents and report on first experiments done to produce computer-aided learning (CAL) applications and instructional design editors that exploit the inferred georeferenced itineraries.…

Getting It Together: An Integrated Approach to Junior High Career Education: A Teachers Guide.

ERIC Educational Resources Information Center

Gorby, Carol J.

The document contains instructional materials for a course called Getting It Together (G.I.T.-7) which is designed for the seventh grade level. The course, an exemplary career education project of the Cal Young Junior High School in Eugene, Oregon focuses on two major areas: (1) self-awareness--22 lessons focusing on learning activities dealing…

Automatic staging of bladder cancer on CT urography

NASA Astrophysics Data System (ADS)

Garapati, Sankeerth S.; Hadjiiski, Lubomir M.; Cha, Kenny H.; Chan, Heang-Ping; Caoili, Elaine M.; Cohan, Richard H.; Weizer, Alon; Alva, Ajjai; Paramagul, Chintana; Wei, Jun; Zhou, Chuan

2016-03-01

Correct staging of bladder cancer is crucial for the decision of neoadjuvant chemotherapy treatment and minimizing the risk of under- or over-treatment. Subjectivity and variability of clinicians in utilizing available diagnostic information may lead to inaccuracy in staging bladder cancer. An objective decision support system that merges the information in a predictive model based on statistical outcomes of previous cases and machine learning may assist clinicians in making more accurate and consistent staging assessments. In this study, we developed a preliminary method to stage bladder cancer. With IRB approval, 42 bladder cancer cases with CTU scans were collected from patient files. The cases were classified into two classes based on pathological stage T2, which is the decision threshold for neoadjuvant chemotherapy treatment (i.e. for stage >=T2) clinically. There were 21 cancers below stage T2 and 21 cancers at stage T2 or above. All 42 lesions were automatically segmented using our auto-initialized cascaded level sets (AI-CALS) method. Morphological features were extracted, which were selected and merged by linear discriminant analysis (LDA) classifier. A leave-one-case-out resampling scheme was used to train and test the classifier using the 42 lesions. The classification accuracy was quantified using the area under the ROC curve (Az). The average training Az was 0.97 and the test Az was 0.85. The classifier consistently selected the lesion volume, a gray level feature and a contrast feature. This predictive model shows promise for assisting in assessing the bladder cancer stage.

A cost-effectiveness analysis of calcipotriol plus betamethasone dipropionate aerosol foam versus gel for the topical treatment of plaque psoriasis.

PubMed

Foley, Peter; Garrett, Sinead; Ryttig, Lasse

2018-01-24

Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. To determine the cost-effectiveness of Cal/BD foam compared with Cal/BD gel from the Australian perspective. A Markov model was developed to evaluate the cost-effectiveness of topical Cal/BD foam and gel for the treatment of people with plaque psoriasis. Treatment effectiveness, safety, and utilities were based on a randomized control trial, resource use was informed by expert opinion, and unit costs were obtained from public sources. Outcomes were reported in terms of 1-year costs, quality-adjusted life years, and incremental cost-effectiveness ratios. All costs were reported in 2017 Australian Dollars. The model showed that patients using Cal/BD foam had more QALYs and higher costs over 1 year compared with patients using Cal/BD gel, resulting in a cost of $13,609 per QALY gained at 4-weeks. When 4 weeks of Cal/BD foam was compared with 8 weeks of Cal/BD gel treatment, Cal/BD foam was $8 less expensive and resulted in 0.006 more QALYs gained. Sensitivity analyses showed that, compared with Cal/BD ointment, Cal/BD foam was associated with an incremental cost of $15,091 per QALY gained. Cal/BD foam is the most cost-effective Cal/BD formulation for the topical treatment of patients with plaque psoriasis.

Lysosomes and unfolded protein response, determinants of differential resistance of melanoma cells to vinca alkaloids.

PubMed

Vincent, Laure-Anais; Attaoua, Chaker; Bellis, Michel; Rozkydalova, Lucie; Hadj-Kaddour, Kamel; Vian, Laurence; Cuq, Pierre

2015-04-01

On account of its strong ability to become chemoresistant after a primary response to drugs, malignant melanoma (MM) remains a therapeutic challenge. This study focuses on acquired resistance to vinca alkaloids (VAs) using VA-resistant MM cell lines (CAL1R-VCR, CAL1R-VDS, and CAL1R-VRB), established by long-term continuous exposure of parental CAL1-wt cells to vincristine (VCR), vindesine (VDS), or vinorelbine (VRB), respectively. Transcriptomic profiling using rma and rdam methods led to distinguish two cell groups: CAL1R-VCR and CAL1R-VDS, CAL1R-VRB, and CAL1-wt. mgsa of the specifically altered genes in the first group evidenced the GO terms 'lysosomal lumen' and 'vacuolar lumen' linked to underexpressed genes, and 'endoplasmic reticulum (ER) stress response' associated with overexpressed genes. A specific reduction of lysosomal enzymes, independent of acidic vacuole organelle (AVO) turnover, was observed (LTG probe) in CAL1R-VCR and CAL1R-VDS cells. It was associated with the specific lowering of cathepsin B and L, known to be involved in the lysosomal pathway of apoptosis. Confirming gene profiling, the same groups (CAL1R-VCR and CAL1R-VDS, CAL1-wt and CAL1R-VRB) could be distinguished regarding the VA-mediated changes on mean size areas and on acidic compartment volumes. These two parameters were reduced in CAL1R-VCR and CAL1R-VDS cells, suggesting a smaller AVO accumulation and thus a reduced sensitivity to lysosomal membrane permeabilization-mediated apoptosis. In addition, 'ER stress response' inhibition by tauroursodeoxycholic acid induced a higher VA sensitization of the first cell group. In conclusion, lysosomes and unfolded protein response could be key determinants of the differential resistance of MM to VAs. © 2015 Société Française de Pharmacologie et de Thérapeutique.

The California-Arizona Minority Partnership for Astronomy Research and Education (CAMPARE): an Educational Experience for Undergraduates at the University of Arizona Alumni Association's Astronomy Camp.

NASA Astrophysics Data System (ADS)

Lemon, Courtney; McCarthy, D.; Rudolph, A.

2011-01-01

The California-Arizona Minority Partnership for Astronomy Research and Education (CAMPARE) is an NSF-funded partnership between the Astronomy Program at Cal Poly Pomona (CPP) and the University of Arizona Steward Observatory designed to promote participation of underrepresented minorities (including women) in astronomy research and education. As part of the education component of the program, CPP undergraduate physics majors and minors are eligible to work as a counselor at the University of Arizona's Astronomy Camp, one of the premier astronomy outreach opportunities in the world. CAMPARE students have the opportunity to work in this learn-by-doing environment with a wide range of students to gain first hand experience of teaching astronomy to students of a wide variety of ages in highly structured educational setting. Cal Poly Pomona students who are interested in education, both formal and informal, work in a variety of camps, from Girl Scout camps to camps for advanced high school students, to further their understanding of what it means to be a professional in the field of education. The CAMPARE student who participated in this program during summer 2010 had the opportunity to work under Dr. Don McCarthy, camp director of University of Arizona's Astronomy Camps for 20 years, and observe the interpersonal relations between campers and staff that is so vital to the learning the students receive. Through these observations, the CAMPARE student was able to learn to gauge students' interest in the material, and experience real life teaching and learning scenarios in the informal education realm.

A Calibration of NICMOS Camera 2 for Low Count Rates

NASA Astrophysics Data System (ADS)

Rubin, D.; Aldering, G.; Amanullah, R.; Barbary, K.; Dawson, K. S.; Deustua, S.; Faccioli, L.; Fadeyev, V.; Fakhouri, H. K.; Fruchter, A. S.; Gladders, M. D.; de Jong, R. S.; Koekemoer, A.; Krechmer, E.; Lidman, C.; Meyers, J.; Nordin, J.; Perlmutter, S.; Ripoche, P.; Schlegel, D. J.; Spadafora, A.; Suzuki, N.

2015-05-01

NICMOS 2 observations are crucial for constraining distances to most of the existing sample of z\\gt 1 SNe Ia. Unlike conventional calibration programs, these observations involve long exposure times and low count rates. Reciprocity failure is known to exist in HgCdTe devices and a correction for this effect has already been implemented for high and medium count rates. However, observations at faint count rates rely on extrapolations. Here instead, we provide a new zero-point calibration directly applicable to faint sources. This is obtained via inter-calibration of NIC2 F110W/F160W with the Wide Field Camera 3 (WFC3) in the low count-rate regime using z∼ 1 elliptical galaxies as tertiary calibrators. These objects have relatively simple near-IR spectral energy distributions, uniform colors, and their extended nature gives a superior signal-to-noise ratio at the same count rate than would stars. The use of extended objects also allows greater tolerances on point-spread function profiles. We find space telescope magnitude zero points (after the installation of the NICMOS cooling system, NCS) of 25.296\\+/- 0.022 for F110W and 25.803\\+/- 0.023 for F160W, both in agreement with the calibration extrapolated from count rates ≳1000 times larger (25.262 and 25.799). Before the installation of the NCS, we find 24.843\\+/- 0.025 for F110W and 25.498\\+/- 0.021 for F160W, also in agreement with the high-count-rate calibration (24.815 and 25.470). We also check the standard bandpasses of WFC3 and NICMOS 2 using a range of stars and galaxies at different colors and find mild tension for WFC3, limiting the accuracy of the zero points. To avoid human bias, our cross-calibration was “blinded” in that the fitted zero-point differences were hidden until the analysis was finalized. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS 5-26555, under programs SM2/NIC-7049, SM2/NIC-7152, CAL/NIC-7607, CAL/NIC-7691, CAL/NIC-7693, GO-7887, CAL/NIC-7902, CAL/NIC-7904, GO/DD-7941, SM3/NIC-8983, SM3/NIC-8986, GTO/ACS-9290, ENG/NIC-9324, CAL/NIC-9325, GO-9352, GO-9375, SNAP-9485, CAL/NIC-9639, GO-9717, GO-9834, GO-9856, CAL/NIC-9995, CAL/NIC-9997, GO-10189, GO-10258, CAL/NIC-10381, CAL/NIC-10454, GO-10496, CAL/NIC-10725, CAL/NIC-10726, GO-10886, CAL/NIC-11060, CAL/NIC-11061, GO-11135, GO-11143, GO-11202, CAL/NIC-11319, GO/DD-11359, SM4/WFC3-11439, SM4/WFC3-11451, GO-11557, GO-11591, GO-11600, GO/DD-11799, CAL/WFC3-11921, CAL/WFC3-11926, GO/DD-12051, GO-12061, GO-12062, GO-12177, CAL/WFC3-12333, CAL/WFC3-12334, CAL/WFC3-12341, GO-12443, GO-12444, GO-12445, CAL/WFC3-12698, CAL/WFC3-12699, GO-12874, CAL/WFC3-13088, and CAL/WFC3-13089.

The Efficiency of Delone Coverings of the Canonical Tilings T^*(A4) and T^*(D6)

NASA Astrophysics Data System (ADS)

Papadopolos, Zorka; Kasner, Gerald

This chapter is devoted to the coverings of the two quasiperiodic canonical tilings T^*(A4) and T^*(D6) T^*(2F), obtained by projection from the root lattices A4 and D6, respectively. In the first major part of this chapter, in Sect. 5.2, we shall introduce a Delone covering C^sT^*(A4) of the 2-dimensional decagonal tiling T^*(A4). In the second major part of this chapter, Sect. 5.3, we summarize the results related to the Delone covering of the icosahedral tiling T^*(D6), CT^*(D6) and determine the zero-, single-, and double- deckings and the resulting thickness of the covering. In the conclusions section, we give some suggestions as to how the definition of the Delone covering might be changed in order to reach some real (full) covering of the icosahedral tiling T^*(D6). In Section 5.2 the definition of the Delone covering is also changed in order to avoid an unnecessary large thickness of the covering.

Fixed Combination Aerosol Foam Calcipotriene 0.005% (Cal) Plus Betamethasone Dipropionate 0.064% (BD) is More Efficacious than Cal or BD Aerosol Foam Alone for Psoriasis Vulgaris

PubMed Central

Tyring, Stephen; Bukhalo, Michael; Alonso-Llamazares, Javier; Olesen, Martin; Lowson, David; Yamauchi, Paul

2016-01-01

Objective: To evaluate the efficacy of fixed combination aerosol foam calcipotriene 0.005% (Cal) plus betamethasone dipropionate 0.064% (BD). Design: Patients were randomized (100:101:101) to receive Cal/BD foam, Cal foam, or BD foam once daily for four weeks. Setting: Twenty-eight United States centers. Participants: 302 patients (≥18 years) with Psoriasis vulgaris (plaque Psoriasis; ≥mild disease severity by physicians global assessment). Measurements: Treatment success of the body (“clear”/”almost clear” from baseline moderate/severe disease; “clear” from baseline mild disease). Involved scalp treatment success was an additional endpoint. Results: Most patients (76%) had moderate Psoriasis of the body (66% for scalp). At Week 4, 45 percent of Cal/BD foam patients achieved treatment success, significantly more than Cal foam (14.9%; OR 4.34 [95%CI 2.16,8.72] P<0.001) or BD foam (30.7%; 1.81 [1.00,3.26] P=0.047). Fifty-three percent of Cal/BD foam patients achieved treatment success of the scalp, significantly greater than Cal foam (35.6%; 1.91 [1.09,3.35] P=0.021), but not BD foam (47.5%; 1.24 [0.71,2.16] P=0.45). Mean modified Psoriasis area and severity index (population baseline 7.6) improved in all groups, with statistically significant differences in Week 4 Cal/BD foam score (2.37) versus Cal foam (4.39; mean difference -2.03 [-2.63][-1.43] P<0.001) and BD foam (3.37; -1.19 [-1.80][-0.59] P<0.001). Four (Cal/BD), 10 (Cal), and 8 (BD) adverse drug reactions were reported. Conclusion: Cal/BD foam was significantly more effective than Cal foam and BD foam in providing treatment success at Week 4 and effective on involved scalp. Trial registration: NCT01536938. PMID:27313822

Applications of long-term watershed research to forest management in California: 50 Years of Learning from the Caspar Creek Watershed Study

Treesearch

Cafferata Peter; Leslie Reid

2013-01-01

For over 50 years, the Caspar Creek Experimental Watersheds, located in western Mendocino County, California, have been the site of long-term cooperative watershed research carried out by the U.S. Forest Service Pacific Southwest Research Station (PSW) and the California Department of Forestry and Fire Protection (CAL FIRE). Preliminary stream flow, suspended...

A Scientific Approach To STEM Education

DTIC Science & Technology

2011-06-16

T My Physics graduate students -- Why excellence in physics courses≠ competence in physics research ? Two years in lab transforms? approached as...learned? (100’s of courses/yr) improved methods average trad. Cal Poly instruction 2. Multiple instructors facilitating same established set of student ...Intro biology Univ. of Wash.– similar research - based instruction •All students improve •Underrepresented students improve more (+1/3 letter grade

The California-Arizona Minority Partnership for Astronomy Research and Education (CAMPARE): Partnering Students to Astronomy at the University of Arizona's Astronomy Camp

NASA Astrophysics Data System (ADS)

Saldivar, Hector; McCarthy, D.; Rudolph, A. L.

2012-01-01

The California-Arizona Minority Partnership for Astronomy Research and Education (CAMPARE) is an NSF-funded partnership between the Astronomy Program at Cal Poly Pomona and the University of Arizona Steward Observatory designed to promote participation of underrepresented minorities, including women, in astronomy research and education. By means of this program, Cal Poly Pomona undergraduates that are either Physics majors or minors are qualified to participate in the program alongside graduate students from the University of Arizona as a camp counselor at the University of Arizona's Astronomy Camp, one of the elite astronomy programs worldwide. Students that participate in the CAMPARE program are granted an opportunity to work in a hands-on environment by teaching astronomy to students from all over the world in a highly structured environment. The CAMPARE student selected for this program in Summer 2011 worked under the supervision of Dr. Don McCarthy, professor at the University of Arizona and Astronomy Camp director for over 20 years, learning to lead a group of students through daily activities and ensure that the students are learning to their maximum potential. Through this experience, the CAMPARE student learned to capture students’ interest in astronomy and was introduced to real life teaching, which has helped prepare him for future experiences to come. We acknowledge the NSF for funding under Award No. AST-0847170, a PAARE Grant for the Calfornia-Arizona Minority Partnership for Astronomy Research and Education (CAMPARE).

Genome-Wide Linkage and Association Mapping of Halo Blight Resistance in Common Bean to Race 6 of the Globally Important Bacterial Pathogen

PubMed Central

Tock, Andrew J.; Fourie, Deidré; Walley, Peter G.; Holub, Eric B.; Soler, Alvaro; Cichy, Karen A.; Pastor-Corrales, Marcial A.; Song, Qijian; Porch, Timothy G.; Hart, John P.; Vasconcellos, Renato C. C.; Vicente, Joana G.; Barker, Guy C.; Miklas, Phillip N.

2017-01-01

Pseudomonas syringae pv. phaseolicola (Psph) Race 6 is a globally prevalent and broadly virulent bacterial pathogen with devastating impact causing halo blight of common bean (Phaseolus vulgaris L.). Common bean lines PI 150414 and CAL 143 are known sources of resistance against this pathogen. We constructed high-resolution linkage maps for three recombinant inbred populations to map resistance to Psph Race 6 derived from the two common bean lines. This was complemented with a genome-wide association study (GWAS) of Race 6 resistance in an Andean Diversity Panel of common bean. Race 6 resistance from PI 150414 maps to a single major-effect quantitative trait locus (QTL; HB4.2) on chromosome Pv04 and confers broad-spectrum resistance to eight other races of the pathogen. Resistance segregating in a Rojo × CAL 143 population maps to five chromosome arms and includes HB4.2. GWAS detected one QTL (HB5.1) on chromosome Pv05 for resistance to Race 6 with significant influence on seed yield. The same HB5.1 QTL, found in both Canadian Wonder × PI 150414 and Rojo × CAL 143 populations, was effective against Race 6 but lacks broad resistance. This study provides evidence for marker-assisted breeding for more durable halo blight control in common bean by combining alleles of race-nonspecific resistance (HB4.2 from PI 150414) and race-specific resistance (HB5.1 from cv. Rojo). PMID:28736566

Impact of managed MediCal on California family practice programs.

PubMed

Zweifler, J A

2001-05-01

An important source of patients for California's family practice program is MediCal. During the past 5 years, MediCal has established a variety of capitated managed care plans. To assess the impact of California's managed MediCal program on the state's 38 family practice training programs. A cross-sectional, retrospective descriptive survey. A 3-page, 11-question survey was developed by family practice residency directors and staff from the California Academy of Family Physicians, San Francisco. The 38 family practice programs in existence in California in September 1997 were stratified by type of managed MediCal in their county and by type of sponsoring institution--university, county, community based, staff-model health maintenance organization, or managed care system. Of the 38 family practice programs, 27 responded; 19 of 27 programs participated in managed MediCal. The total number of family health center patients, and the percentage of MediCal patients (48%-60%) at family practice programs was similar when stratified by programs with and without managed MediCal and by type of sponsorship. Most programs reported that they were able to compete effectively, although most also reported increased administrative, nursing, and front office costs. Managed MediCal patients were directly assigned to residents in only 3 of 19 programs. The introduction of managed MediCal has not adversely affected the number of patients cared for in California's family practice programs. Continued vigilance regarding California family practice programs' involvement in managed MediCal, including collection of accurate data on the number of MediCal patients and the financial and educational implications for California's family practice programs, is warranted.

Fabrication of Calix[4]arene Derivative Monolayers to Control Orientation of Antibody Immobilization

PubMed Central

Chen, Hongxia; Liu, Feng; Qi, Fangjie; Koh, Kwangnak; Wang, Keming

2014-01-01

Three calix[4]arene (Cal-4) derivatives which separately contain ethylester (1), carboxylic acid (2), and crownether (3) at the lower rim with a common reactive thiol at the upper rim were synthesized and constructed to self-assembled monolayers (SAMs) on Au films. After spectroscopic characterization of the monolayers, surface coverage and orientation of antibody immobilized on the Cal-4 derivative SAMs were studied by surface plasmon resonance (SPR) technique. Experimental results revealed that the antibody could be immobilized on the Cal-4 derivatives spontaneously. The orientation of absorbed antibody on the Cal-4 derivative SAMs is related to the SAM’s dipole moment. The possible orientations of the antibody immobilized on the Cal-4 derivative 1 SAM are lying-on or side-on, while on the Cal-4 derivative 2 and Cal-4 derivative 3 head-on and end-on respectively. These experimental results demonstrate the surface dipole moment of Cal-4 derivative appears to be an important factor to antibody orientation. Cal-4 derivatives are useful in developing site direct protein chips. PMID:24690993

CAL-laborate: A Collaborative Publication on the Use of Computer Aided Learning for Tertiary Level Physical Sciences and Geosciences.

ERIC Educational Resources Information Center

Fernandez, Anne, Ed.; Sproats, Lee, Ed.; Sorensen, Stacey, Ed.

2000-01-01

The science community has been trying to use computers in teaching for many years. There has been much conformity in how this was to be achieved, and the wheel has been re-invented again and again as enthusiast after enthusiast has "done their bit" towards getting computers accepted. Computers are now used by science undergraduates (as well as…

Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure.

PubMed

Bond, Richard C; Bryant, Simon M; Watson, Judy J; Hancox, Jules C; Orchard, Clive H; James, Andrew F

2017-03-01

Constitutive regulation by PKA has recently been shown to contribute to L-type Ca 2+ current ( I CaL ) at the ventricular t-tubule in heart failure. Conversely, reduction in constitutive regulation by PKA has been proposed to underlie the downregulation of atrial I CaL in heart failure. The hypothesis that downregulation of atrial I CaL in heart failure involves reduced channel phosphorylation was examined. Anesthetized adult male Wistar rats underwent surgical coronary artery ligation (CAL, N =10) or equivalent sham-operation (Sham, N =12). Left atrial myocytes were isolated ~18 wk postsurgery and whole cell currents recorded (holding potential=-80 mV). I CaL activated by depolarizing pulses to voltages from -40 to +50 mV were normalized to cell capacitance and current density-voltage relations plotted. CAL cell capacitances were ~1.67-fold greater than Sham ( P ≤ 0.0001). Maximal I CaL conductance ( G max ) was downregulated more than 2-fold in CAL vs. Sham myocytes ( P < 0.0001). Norepinephrine (1 μmol/l) increased G max >50% more effectively in CAL than in Sham so that differences in I CaL density were abolished. Differences between CAL and Sham G max were not abolished by calyculin A (100 nmol/l), suggesting that increased protein dephosphorylation did not account for I CaL downregulation. Treatment with either H-89 (10 μmol/l) or AIP (5 μmol/l) had no effect on basal currents in Sham or CAL myocytes, indicating that, in contrast to ventricular myocytes, neither PKA nor CaMKII regulated basal I CaL Expression of the L-type α 1C -subunit, protein phosphatases 1 and 2A, and inhibitor-1 proteins was unchanged. In conclusion, reduction in PKA-dependent regulation did not contribute to downregulation of atrial I CaL in heart failure. NEW & NOTEWORTHY Whole cell recording of L-type Ca 2+ currents in atrial myocytes from rat hearts subjected to coronary artery ligation compared with those from sham-operated controls reveals marked reduction in current density in heart failure without change in channel subunit expression and associated with altered phosphorylation independent of protein kinase A. Copyright © 2017 the American Physiological Society.

The ATLAS tile calorimeter performance at the LHC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calkins, R.

The Tile Calorimeter (TileCal), the central section of the hadronic calorimeter of the ATLAS experiment, is a key detector component to detect hadrons, jets and taus and to measure the missing transverse energy. Due to the very good muon signal to noise ratio it assists the spectrometer in the identification and reconstruction of muons. TileCal is built of steel and scintillating tiles coupled to optical fibers and read out by photomultipliers. The calorimeter is equipped with systems that allow to monitor and to calibrate each stage of the read out system exploiting different signal sources: laser light, charge injection andmore » a radioactive source. The performance of the calorimeter has been measured and monitored using calibration data, random triggered data, cosmic muons and more importantly LHC collision events. The results presented here assess the absolute energy scale calibration precision, the energy and timing uniformity and the synchronization precision. The ensemble of the results demonstrates a very good understanding of the performance of the Tile Calorimeter that is proved to be well within the design expectations. (authors)« less

CalSimHydro Tool - A Web-based interactive tool for the CalSim 3.0 Hydrology Prepropessor

NASA Astrophysics Data System (ADS)

Li, P.; Stough, T.; Vu, Q.; Granger, S. L.; Jones, D. J.; Ferreira, I.; Chen, Z.

2011-12-01

CalSimHydro, the CalSim 3.0 Hydrology Preprocessor, is an application designed to automate the various steps in the computation of hydrologic inputs for CalSim 3.0, a water resources planning model developed jointly by California State Department of Water Resources and United States Bureau of Reclamation, Mid-Pacific Region. CalSimHydro consists of a five-step FORTRAN based program that runs the individual models in succession passing information from one model to the next and aggregating data as required by each model. The final product of CalSimHydro is an updated CalSim 3.0 state variable (SV) DSS input file. CalSimHydro consists of (1) a Rainfall-Runoff Model to compute monthly infiltration, (2) a Soil moisture and demand calculator (IDC) that estimates surface runoff, deep percolation, and water demands for natural vegetation cover and various crops other than rice, (3) a Rice Water Use Model to compute the water demands, deep percolation, irrigation return flow, and runoff from precipitation for the rice fields, (4) a Refuge Water Use Model that simulates the ponding operations for managed wetlands, and (5) a Data Aggregation and Transfer Module to aggregate the outputs from the above modules and transfer them to the CalSim SV input file. In this presentation, we describe a web-based user interface for CalSimHydro using Google Earth Plug-In. The CalSimHydro tool allows users to - interact with geo-referenced layers of the Water Budget Areas (WBA) and Demand Units (DU) displayed over the Sacramento Valley, - view the input parameters of the hydrology preprocessor for a selected WBA or DU in a time series plot or a tabular form, - edit the values of the input parameters in the table or by downloading a spreadsheet of the selected parameter in a selected time range, - run the CalSimHydro modules in the backend server and notify the user when the job is done, - visualize the model output and compare it with a base run result, - download the output SV file to be used to run CalSim 3.0. The CalSimHydro tool streamlines the complicated steps to configure and run the hydrology preprocessor by providing a user-friendly visual interface and back-end services to validate user inputs and manage the model execution. It is a powerful addition to the new CalSim 3.0 system.

Late Quaternary palaeoecological and palaeoclimatological reconstruction in the Gutaiului Mountains, northwest Romania

NASA Astrophysics Data System (ADS)

Feurdean, Angelica; Bennike, Ole

2004-12-01

Macrofossil, pollen, lithostratigraphy, mineral magnetic measurements (SIRM and magnetic susceptibility), loss-on-ignition, and AMS radiocarbon dating on sediments from two former crater lakes, situated at moderate altitudes in the Gutaiului Mountains of northwest Romania, allow reconstruction of Late Quaternary climate and environment. Shrubs and herbs with steppe and montane affinities along with stands of Betula and Pinus, colonised the surroundings of the sites prior to 14 700 cal. yr BP and the inferred climatic conditions were cold and dry. The gradual transition to open Pinus-Betula forests, slightly higher lake water temperatures, and higher lake productivity, indicate more stable environmental conditions between 14 700 and 14 100 cal. yr BP. This development was interrupted by cooler and drier climatic conditions between 14 100 and 13 800 cal. yr BP, as inferred from a reduction of open forests to patches, or stands, of Pinus, Betula, Larix, Salix and Populus. The expansion of a denser boreal forest, dominated by Picea, but including Pinus, Larix, Betula, Salix, and Ulmus started at 13 800 cal. yr BP, although the forest density seems to have been reduced between 13400 and 13200cal.yrBP. Air temperature and moisture availability gradually increased, but a change towards drier conditions is seen at 13400cal.yrBP. A distinct decrease in temperature and humidity between 12900 and 11500cal.yrBP led to a return of open vegetation, with patches of Betula, Larix, Salix, Pinus and Alnus and individuals of Picea. Macrofossils and pollen of aquatic plants indicate rising lake water temperatures and increased aquatic productivity already by ca. 11800cal.yrBP, 300 years earlier than documented by the terrestrial plant communities. At the onset of the Holocene, 11500cal.yrBP, forests dominated by Betula, Pinus and Larix expanded and were followed by dense Ulmus forests with Picea, Betula and Pinus at 11250cal.yrBP. Larix pollen was not found, but macrofossil evidence indicates that Larix was an important forest constituent at the onset of the Holocene. Moister conditions were followed by a dry period starting about 10600cal.yrBP, which was more pronounced between 8600 and 8200cal.yrBP, as inferred from aquatic macrofossils. The maximum expansion of Tilia, Quercus, Fraxinus and Acer between 10700 and 8600cal.yrBP may reflect a more continental climate. A drier and/or cooler climate could have been responsible for the late expansion (10300cal.yrBP) and late maximum (9300cal.yrBP) of Corylus. Increased water stress, and possibly cooler conditions around 8600cal.yrBP, may have caused a reduction of Ulmus, Tilia, Quercus and Fraxinus. After 8200cal.yrBP moisture increased and the forests included Picea, Tilia, Quercus and Fraxinus. Copyright

Peer Learning Strategies: Acknowledging Lecturers' Concerns of the Student Learning Assistant Scheme on a New Higher Education Campus

ERIC Educational Resources Information Center

Kodabux, Adeelah; Hoolash, Bheshaj Kumar Ashley

2015-01-01

The Student Learning Assistant (SLA) scheme was introduced in 2010 at Middlesex University Mauritius Branch Campus (MUMBC). The scheme is similar to traditional peer learning strategies, such as Peer Assisted Learning (PAL) and Peer Assisted Study Sessions (PASS), which are widely operated in higher education environments to motivate student…

Sediment record of environmental change at Lake Lop Nur (Xinjiang, NW China) from 13.0 to 5.6 cal ka BP

NASA Astrophysics Data System (ADS)

Wang, Jingzhong; Jia, Hongjuan

2017-09-01

Lake Lop Nur is located in the eastern part of the Tarim Basin in Xinjiang, northwestern China. A 220-cm-long sediment core was collected from the center of the ear-shaped depression forming the basin and dated with AMS14C. Grain size, total organic matter (TOC), total nitrogen (TN), and TOC/TN (C/N) analyses were used to reconstruct climatic conditions from 13.0 to 5.6 cal ka BP. The results showed five main climatic stages. Zone I (13.0-11.3 cal ka BP) was a wet-dry environment, whereas Zone II (11.3-8.9 cal ka BP) consisted of a primarily wet environment. Zone III (8.9-7.7 cal ka BP) was subdivided into Zone IIIa (8.9-8.2 cal ka BP) that indicated lake constriction and dry climate, and Zone IIIb (8.2-7.7 cal ka BP) in which the proxies indicated wet conditions. In Zone IV (7.7-6.6 cal ka BP), the climate presented a bit wet conditions. In Zone V (6.6-5.6 cal ka BP), abundant glauberite is present in the sediment and silt dominates the lithology; these results indicate the lake shrank and the overall climate was dry. Abrupt environmental events were also identified, including six dry events at 11.0, 10.5, 9.3, 8.6, 8.2, and 7.6 cal ka BP and one flood event from 7.8 to 7.7 cal ka BP in the Early-Middle Holocene.

78 FR 1264 - CalAmp Wireless Networks Corporation, Waseca, MN; Notice of Negative Determination Regarding...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-08

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-81,646] CalAmp Wireless Networks...; CalAmp Wireless Networks Corporation, Waseca, Minnesota; expires on December 2, 2013). Conclusion Due to the eligibility of workers and former workers of CalAmp Wireless Networks Corporation, Waseca...

Technology-Assisted Learning: A Longitudinal Field Study of Knowledge Category, Learning Effectiveness and Satisfaction in Language Learning

ERIC Educational Resources Information Center

Hui, W.; Hu, P. J.-H.; Clark, T. H. K.; Tam, K. Y.; Milton, J.

2008-01-01

A field experiment compares the effectiveness and satisfaction associated with technology-assisted learning with that of face-to-face learning. The empirical evidence suggests that technology-assisted learning effectiveness depends on the target knowledge category. Building on Kolb's experiential learning model, we show that technology-assisted…

Self-Control of Haptic Assistance for Motor Learning: Influences of Frequency and Opinion of Utility

PubMed Central

Williams, Camille K.; Tseung, Victrine; Carnahan, Heather

2017-01-01

Studies of self-controlled practice have shown benefits when learners controlled feedback schedule, use of assistive devices and task difficulty, with benefits attributed to information processing and motivational advantages of self-control. Although haptic assistance serves as feedback, aids task performance and modifies task difficulty, researchers have yet to explore whether self-control over haptic assistance could be beneficial for learning. We explored whether self-control of haptic assistance would be beneficial for learning a tracing task. Self-controlled participants selected practice blocks on which they would receive haptic assistance, while participants in a yoked group received haptic assistance on blocks determined by a matched self-controlled participant. We inferred learning from performance on retention tests without haptic assistance. From qualitative analysis of open-ended questions related to rationales for/experiences of the haptic assistance that was chosen/provided, themes emerged regarding participants’ views of the utility of haptic assistance for performance and learning. Results showed that learning was directly impacted by the frequency of haptic assistance for self-controlled participants only and view of haptic assistance. Furthermore, self-controlled participants’ views were significantly associated with their requested haptic assistance frequency. We discuss these findings as further support for the beneficial role of self-controlled practice for motor learning. PMID:29255438

Using computer-assisted learning to engage diverse learning styles in understanding business management principles.

PubMed

Frost, Mary E; Derby, Dustin C; Haan, Andrea G

2013-01-01

Objective : Changes in small business and insurance present challenges for newly graduated chiropractors. Technology that reaches identified, diverse learning styles may assist the chiropractic student in business classes to meet course outcomes better. Thus, the purpose of our study is to determine if the use of technology-based instructional aids enhance students' mastery of course learning outcomes. Methods : Using convenience sampling, 86 students completed a survey assessing course learning outcomes, learning style, and the helpfulness of lecture and computer-assisted learning related to content mastery. Quantitative analyses occurred. Results : Although respondents reported not finding the computer-assisted learning as helpful as the lecture, significant relationships were found between pre- and post-assisted learning measures of the learning outcomes 1 and 2 for the visual and kinesthetic groups. Surprisingly, however, all learning style groups exhibited significant pre- and post-assisted learning appraisal relationships with learning outcomes 3 and 4. Conclusion : While evidence exists within the current study of a relationship between students' learning of the course content corollary to the use of technologic instructional aids, the exact nature of the relationship remains unclear.

Using computer-assisted learning to engage diverse learning styles in understanding business management principles.

PubMed

Frost, Mary E; Derby, Dustin C; Haan, Andrea G

2013-06-27

Objective : Changes in small business and insurance present challenges for newly graduated chiropractors. Technology that reaches identified, diverse learning styles may assist the chiropractic student in business classes to meet course outcomes better. Thus, the purpose of our study is to determine if the use of technology-based instructional aids enhance students' mastery of course learning outcomes. Methods : Using convenience sampling, 86 students completed a survey assessing course learning outcomes, learning style, and the helpfulness of lecture and computer-assisted learning related to content mastery. Quantitative analyses occurred. Results : Although respondents reported not finding the computer-assisted learning as helpful as the lecture, significant relationships were found between pre- and post-assisted learning measures of the learning outcomes 1 and 2 for the visual and kinesthetic groups. Surprisingly, however, all learning style groups exhibited significant pre- and post-assisted learning appraisal relationships with learning outcomes 3 and 4. Conclusion : While evidence exists within the current study of a relationship between students' learning of the course content corollary to the use of technologic instructional aids, the exact nature of the relationship remains unclear.

Peer-Assisted Learning.

ERIC Educational Resources Information Center

Topping, Keith, Ed.; Ehly, Stewart, Ed.

Peer-Assisted Learning (PAL) involves students consciously assisting others to learn, and in so doing, learning more effectively themselves. PAL encompasses peer tutoring, peer modeling, peer education, peer counseling, peer monitoring, and peer assessment, which are differentiated from other more general "cooperative learning" methods.…

Scale-invariant properties of public-debt growth

NASA Astrophysics Data System (ADS)

Petersen, A. M.; Podobnik, B.; Horvatic, D.; Stanley, H. E.

2010-05-01

Public debt is one of the important economic variables that quantitatively describes a nation's economy. Because bankruptcy is a risk faced even by institutions as large as governments (e.g., Iceland), national debt should be strictly controlled with respect to national wealth. Also, the problem of eliminating extreme poverty in the world is closely connected to the study of extremely poor debtor nations. We analyze the time evolution of national public debt and find "convergence": initially less-indebted countries increase their debt more quickly than initially more-indebted countries. We also analyze the public debt-to-GDP ratio {\\cal R} , a proxy for default risk, and approximate the probability density function P({\\cal R}) with a Gamma distribution, which can be used to establish thresholds for sustainable debt. We also observe "convergence" in {\\cal R} : countries with initially small {\\cal R} increase their {\\cal R} more quickly than countries with initially large {\\cal R} . The scaling relationships for debt and {\\cal R} have practical applications, e.g. the Maastricht Treaty requires members of the European Monetary Union to maintain {\\cal R} < 0.6 .

Integrated approach to colorectal anastomotic leakage: Communication, infection and healing disturbances

PubMed Central

Sparreboom, Cloë L; Wu, Zhou-Qiao; Ji, Jia-Fu; Lange, Johan F

2016-01-01

Colorectal anastomotic leakage (CAL) remains a major complication after colorectal surgery. Despite all efforts during the last decades, the incidence of CAL has not decreased. In this review, we summarize the available strategies regarding prevention, prediction and intervention of CAL and categorize them into three categories: communication, infection and healing disturbances. These three major factors actively interact during the onset of CAL. We aim to provide an integrated approach to CAL based on its etiology. The intraoperative air leak test, intraoperative endoscopy, radiological examinations and stoma construction mainly aim to detect and to prevent communication between the intra- and extra-luminal content. Other strategies including postoperative drainage, antibiotics, and infectious-parameter evaluation are intended to detect and prevent anastomotic or peritoneal infection. Most currently available interventions for CAL focus on the control of communication and infection, while strategies targeting the healing disturbances such as lifestyle changes, oxygen therapy and evaluation of metabolic biomarkers still lack wide clinical application. This simplified categorization may contribute to an integrated understanding of CAL. We strongly believe that this integrated approach should be taken into consideration during clinical practice. An integrated approach to CAL could contribute to a better understanding of the etiology of CAL and eventually better patient outcome. PMID:27621570

A Peer-Assisted Learning Experience in Computer Programming Language Learning and Developing Computer Programming Skills

ERIC Educational Resources Information Center

Altintas, Tugba; Gunes, Ali; Sayan, Hamiyet

2016-01-01

Peer learning or, as commonly expressed, peer-assisted learning (PAL) involves school students who actively assist others to learn and in turn benefit from an effective learning environment. This research was designed to support students in becoming more autonomous in their learning, help them enhance their confidence level in tackling computer…

Low-visibility light-intensity laser-triggered release of entrapped calcein from 1,2-bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine liposomes is mediated through a type I photoactivation pathway

PubMed Central

Yavlovich, Amichai; Viard, Mathias; Gupta, Kshitij; Sine, Jessica; Vu, Mylinh; Blumenthal, Robert; Tata, Darrell B; Puri, Anu

2013-01-01

We recently reported on the physical characteristics of photo-triggerable liposomes containing dipalmitoylphosphatidylcholine (DPPC), and 1,2-bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC) carrying a photo agent as their payload. When exposed to a low-intensity 514 nm wavelength (continuous-wave) laser light, these liposomes were observed to release entrapped calcein green (Cal-G; Ex/Em 490/517 nm) but not calcein blue (Cal-B; Ex/Em 360/460 nm). In this study, we have investigated the mechanism for the 514 nm laser-triggered release of the Cal-G payload using several scavengers that are known specifically to inhibit either type I or type II photoreaction pathways. Liposomes containing DPPC:DC8,9PC: distearoylphosphatidylethanolamine (DSPE)-polyethylene glycol (PEG)-2000 (86:10:04 mole ratio) were loaded either with fluorescent (calcein) or nonfluorescent (3H-inulin) aqueous markers. In addition, a non-photo-triggerable formulation (1-palmitoyl-2-oleoyl phosphatidylcholine [POPC]:DC8,9PC:DSPE-PEG2000) was also studied with the same payloads. The 514 nm wavelength laser exposure on photo-triggerable liposomes resulted in the release of Cal-G but not that of Cal-B or 3H-inulin, suggesting an involvement of a photoactivated state of Cal-G due to the 514 nm laser exposure. Upon 514 nm laser exposures, substantial hydrogen peroxide (H2O2, ≈100 μM) levels were detected from only the Cal-G loaded photo-triggerable liposomes but not from Cal-B-loaded liposomes (≤10 μM H2O2). The Cal-G release from photo-triggerable liposomes was found to be significantly inhibited by ascorbic acid (AA), resulting in a 70%–80% reduction in Cal-G release. The extent of AA-mediated inhibition of Cal-G release from the liposomes also correlated with the consumption of AA. No AA consumption was detected in the 514 nm laserexposed Cal B-loaded liposomes, thus confirming a role of photoactivation of Cal-G in liposome destabilization. Inclusion of 100 mM K3Fe(CN)6 (a blocker of electron transfer) in the liposomes substantially inhibited Cal-G release, whereas inclusion of 10 mM sodium azide (a blocker of singlet oxygen of type II photoreaction) in the liposomes failed to block 514 nm laser-triggered Cal-G release. Taken together, we conclude that low-intensity 514 nm laser-triggered release of Cal-G from photo-triggerable liposomes involves the type I photoreaction pathway. PMID:23901274

Assistive technology for postsecondary students with learning disabilities.

PubMed

Day, S L; Edwards, B J

1996-09-01

An increasing number of students with learning disabilities are attending postsecondary institutions. To meet the educational demands of these students, support service providers will likely rely on assistive technology. This article lists types of assistive technology appropriate for use with persons with learning disabilities at the postsecondary level and discusses ways in which assistive technology enhances learning. Additionally, an overview of legislation that has had an impact on assistive technology at the postsecondary level is presented. Issues involving assistive technology programs at the postsecondary level are discussed. Postsecondary assistive technology program components, device selection, and training guidelines also are outlined.

Marine04 Marine radiocarbon age calibration, 26 ? 0 ka BP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughen, K; Baille, M; Bard, E

2004-11-01

New radiocarbon calibration curves, IntCal04 and Marine04, have been constructed and internationally ratified to replace the terrestrial and marine components of IntCal98. The new calibration datasets extend an additional 2000 years, from 0-26 ka cal BP (Before Present, 0 cal BP = AD 1950), and provide much higher resolution, greater precision and more detailed structure than IntCal98. For the Marine04 curve, dendrochronologically dated tree-ring samples, converted with a box-diffusion model to marine mixed-layer ages, cover the period from 0-10.5 ka cal BP. Beyond 10.5 ka cal BP, high-resolution marine data become available from foraminifera in varved sediments and U/Th-dated corals.more » The marine records are corrected with site-specific {sup 14}C reservoir age information to provide a single global marine mixed-layer calibration from 10.5-26.0 ka cal BP. A substantial enhancement relative to IntCal98 is the introduction of a random walk model, which takes into account the uncertainty in both the calendar age and the radiocarbon age to calculate the underlying calibration curve. The marine datasets and calibration curve for marine samples from the surface mixed layer (Marine04) are discussed here. The tree-ring datasets, sources of uncertainty, and regional offsets are presented in detail in a companion paper by Reimer et al.« less

Toward Mobile Assisted Language Learning Apps for Professionals That Integrate Learning into the Daily Routine

ERIC Educational Resources Information Center

Pareja-Lora, Antonio; Arús-Hita, Jorge; Read, Timothy; Rodríguez-Arancón, Pilar; Calle-Martínez, Cristina; Pomposo, Lourdes; Martín-Monje, Elena; Bárcena, Elena

2013-01-01

In this short paper, we present some initial work on Mobile Assisted Language Learning (MALL) undertaken by the ATLAS research group. ATLAS embraced this multidisciplinary field cutting across Mobile Learning and Computer Assisted Language Learning (CALL) as a natural step in their quest to find learning formulas for professional English that…

Peer-Assisted Learning in Mathematics: An Observational Study of Student Success

ERIC Educational Resources Information Center

Cheng, Dorothy; Walters, Matthew

2009-01-01

The Peer-Assisted Learning (PAL) program at the University of Minnesota has drawn from the best practices of Supplemental Instruction, Peer-Led Team Learning, Structured Learning Assistance, the Emerging Scholars Program, and other successful postsecondary peer cooperative learning models to establish guiding principles for structuring learning…

Kinetic study of Candida antarctica lipase B immobilization using poly(methyl methacrylate) nanoparticles obtained by miniemulsion polymerization as support.

PubMed

Valério, Alexsandra; Nicoletti, Gabrieli; Cipolatti, Eliane P; Ninow, Jorge L; Araújo, Pedro H H; Sayer, Cláudia; de Oliveira, Débora

2015-03-01

With the objective to obtain immobilized Candida antarctica lipase B (CalB) with good activity and improved utilization rate, this study evaluated the influence of enzyme and crodamol concentrations and initiator type on the CalB enzyme immobilization in nanoparticles consisting of poly(methyl methacrylate) (PMMA) obtained by miniemulsion polymerization. The kinetic study of immobilized CalB enzyme in PMMA nanoparticles was evaluated in terms of monomer conversion, particle size, zeta potential, and relative activity. The optimum immobilization condition for CalB was compared with free enzyme in the p-NPL hydrolysis activity measurement. Results showed a higher CalB enzyme stability after 20 hydrolysis cycles compared with free CalB enzyme; in particular, the relative immobilized enzyme activity was maintained up to 40%. In conclusion, PMMA nanoparticles proved to be a good support for the CalB enzyme immobilization and may be used as a feasible alternative catalyst in industrial processes.

The Return of Two-Class Medicine—III Effects of Medi-Cal Reform

PubMed Central

Waitzkin, Howard

1985-01-01

California's drastic Medi-Cal reforms have created great difficulties in health care for the poor. Patients' clinical problems seldom are apparent in descriptions of changes in public insurance programs. Rapidly escalating costs of Medi-Cal led to irresistible pressures for reform, especially from the business community. The new Medi-Cal regulations provide for prospective contracts with hospitals for inpatient services, the transfer of “Medically Indigent Adults” to the responsibility of county governments and various other straightforward funding cutbacks. Confusion, disruption of services and adverse health outcomes have accompanied the Medi-Cal reforms. PMID:3892917

An Analysis of the Requirements and Potential Opportunities for the Future Education of Law Enforcement Intelligence Analysts

DTIC Science & Technology

2008-03-01

thinking as a specialized course. None of these schools requires a foreign language. Only Cal State Fullerton and Sacrament State requires students to...research methods. None of the schools require a foreign language. AMU offers critical thinking as an elective from its General Program for students ...analysts should learn more about the religion. Question Six: Instruction in which of these types of philosophies (Western, Eastern, Middle Eastern, or

M1 Abrams Tank Procedure Guides

DTIC Science & Technology

1982-07-01

Vemp =. ... . Mheek mustlam- sitlee no"Ageper- 2. Cal.5 . . swetgh: (PAge LI) 3. CaLS . ... Zen (pag 13) BOUzSzMT M CAL. SO I.. Teak peatima. .. lafel...Cleee ,-. 13.~~ .eds a." . .ege ..... abeW "d us (P P U) :. -z KINK CAL. 50 3. vempe " .. ... .led (pg ) 2. o . .. .ad tio"ge mgety .. 1 4. IC omee .C.1

Computer Assisted Language Learning. Routledge Studies in Computer Assisted Language Learning

ERIC Educational Resources Information Center

Pennington, Martha

2011-01-01

Computer-assisted language learning (CALL) is an approach to language teaching and learning in which computer technology is used as an aid to the presentation, reinforcement and assessment of material to be learned, usually including a substantial interactive element. This books provides an up-to date and comprehensive overview of…

78 FR 68987 - Guides for Private Vocational and Distance Education Schools

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-18

... placement assistance and assistance overcoming language barriers or learning disabilities, it will provide... learning, the source of funding for student loans, and security policies and crime statistics. In response... misrepresentations relating to student financial assistance, assistance overcoming language barriers or learning...

CalR is required for the expression of T6SS2 and the adhesion of Vibrio parahaemolyticus to HeLa cells.

PubMed

Zhang, Lingyu; Osei-Adjei, George; Zhang, Ying; Gao, He; Yang, Wenhui; Zhou, Dongsheng; Huang, Xinxiang; Yang, Huiying; Zhang, Yiquan

2017-08-01

Vibrio parahaemolyticus expresses one major virulence determinant T6SS2, which is constituted into three putative operons, i.e., VPA1027-1024, VPA1043-1028, and VPA1044-1046. CalR, a LysR-type transcriptional regulator, was originally identified as a repressor of the swarming motility and T3SS1 gene expression. As shown in this study, CalR binds to the promoter-proximal region of each of the three operons to activate their transcription, and moreover, CalR activates the adhesion of V. parahaemolyticus to HeLa cells. In addition, competitive EMSAs demonstrated that CalR acts as an antagonist of H-NS in V. parahaemolyticus. Collectively, these studies confirmed a new physiological role for CalR in V. parahaemolyticus.

ZeroCal: Automatic MAC Protocol Calibration

NASA Astrophysics Data System (ADS)

Meier, Andreas; Woehrle, Matthias; Zimmerling, Marco; Thiele, Lothar

Sensor network MAC protocols are typically configured for an intended deployment scenario once and for all at compile time. This approach, however, leads to suboptimal performance if the network conditions deviate from the expectations. We present ZeroCal, a distributed algorithm that allows nodes to dynamically adapt to variations in traffic volume. Using ZeroCal, each node autonomously configures its MAC protocol at runtime, thereby trying to reduce the maximum energy consumption among all nodes. While the algorithm is readily usable for any asynchronous low-power listening or low-power probing protocol, we validate and demonstrate the effectiveness of ZeroCal on X-MAC. Extensive testbed experiments and simulations indicate that ZeroCal quickly adapts to traffic variations. We further show that ZeroCal extends network lifetime by 50% compared to an optimal configuration with identical and static MAC parameters at all nodes.

Variability in attachment of the coracoacromial ligament in relation with its morphology.

PubMed

Alraddadi, Abdulrahman; Alashkham, Abduelmenem; Lamb, Clare; Soames, Roger

2017-12-01

The coracoacromial ligament (CAL) presents with variable morphology and plays a significant role in the development of subacromial impingement syndrome. Sectioning the CAL has been suggested to relieve impingement of the rotator cuff. The aim of the current study was to investigate the CAL attachment in relation with ligament morphology. The CAL was investigated in 220 cadaveric shoulders from 58 males and 59 females, with a median age of 82 years (range 53-102 years). CALs were classified according to three factors: (1) number of bands present; (2) shape; and (3) attachment to the acromial and coracoid processes. 35 (16%) CALs had a single band, 84 (38%) two bands, and 101 (46%) three or more bands. CAL shape was either broadband (14: 6%), quadrangular (21: 10%), Y-shaped (84: 38%), or multiple-banded (101: 46%). More ligaments were attached to the medial aspect of the acromion (60%) and medial end of the coracoid (75%) than those restricted to the anterior edge of the acromion (40%) and posterior aspect of the coracoid (25%). Multiple-banded ligaments attached significantly more medially at the acromion and coracoid processes, while single band ligament attachments were restricted to the anterior edge of the acromion and posterior aspect of the coracoid process. The CAL has variable morphology and attachments with interconnections to different structures around the shoulder. CALs with a medial acromial attachment may narrow the subacromial space leading to further shoulder impingement.

Learning Assistance: Charting Our Course. Proceedings of the Annual Conference of the Western College Reading Association (11th, Long Beach, California, March 16-19, 1978). Volume XI.

ERIC Educational Resources Information Center

Enright, Gwyn, Ed.

The articles in this collection focus on learning assistance and other components of college reading instruction. The topics of the 35 articles include the following: (1) charting a realistic course for learning assistance, (2) modern measurement technology, (3) a national survey of learning assistance evaluation, (4) students' cognitive…

Intelligent Computer-Assisted Language Learning.

ERIC Educational Resources Information Center

Harrington, Michael

1996-01-01

Introduces the field of intelligent computer assisted language learning (ICALL) and relates them to current practice in computer assisted language learning (CALL) and second language learning. Points out that ICALL applies expertise from artificial intelligence and the computer and cognitive sciences to the development of language learning…

The Human Mind As General Problem Solver

NASA Astrophysics Data System (ADS)

Gurr, Henry

2011-10-01

Since leaving U Cal Irvine Neutrino Research, I have been a University Physics Teacher, and an Informal Researcher Of Human Functionality. My talk will share what I discovered about the best ways to learn, many of which are regularities that are to be expected from the Neuronal Network Properties announced in the publications of physicist John Joseph Hopfield. Hopfield's Model of mammalian brain-body, provides solid instructive understanding of how best Learn, Solve Problems, Live! With it we understand many otherwise puzzling features of our intellect! Examples Why 1) Analogies and metaphors powerful in class instruction, ditto poems. 2) Best learning done in physical (Hands-On) situations with tight immediate dynamical feedback such as seen in learning to ride bike, drive car, speak language, etc. 3) Some of the best learning happens in seeming random exploration, bump around, trial and error. 4) Scientific discoveries happen, with no apparent effort, at odd moments. 5) Important discoveries DEPEND on considerable frustrating effort, then Flash of Insight AHA EURIKA.

The Long Run Impacts of Merit Aid: Evidence from California's Cal Grant. CEPA Working Paper No. 16-13

ERIC Educational Resources Information Center

Bettinger, Eric; Gurantz, Oded; Kawano, Laura; Sacerdote, Bruce

2016-01-01

We examine the impacts of being awarded a Cal Grant, among the most generous state merit aid programs. We exploit variation in eligibility rules using GPA and family income cutoffs that are ex ante unknown to applicants. Cal Grant eligibility increases degree completion by 2 to 5 percentage points in our reduced form estimates. Cal Grant also…

Purification of legumin-like proteins from Coffea arabica and Coffea racemosa seeds and their insecticidal properties toward cowpea weevil ( Callosobruchus maculatus ) (Coleoptera: Bruchidae).

PubMed

Coelho, Mirela Batista; Macedo, Maria Lígia Rodrigues; Marangoni, Sérgio; Silva, Desiree Soares da; Cesarino, Igor; Mazzafera, Paulo

2010-03-10

Legumin-like proteins from seeds of Coffea arabica (CaL-1 and CaL-2) and Coffea racemosa (CrL-1 and CrL-2) were characterized and isolated by gel filtration and reverse-phase chromatography. The insecticidal properties of the purified proteins were tested against Callosobruchus maculatus using artificial diets. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analyses indicated that CaL-1 is composed of two subunits of 33 and 24 kDa, while CaL-2, CrL-1, and CrL-2 were monomeric with a single band of 14 kDa. The LD(50) values were 0.5% (w/w) for CaL-1 and 0.3% (w/w) for CaL-2, CrL-1, and CrL-2. ED(50) at 0.3% was assessed for all protein concentrations. The legumin-like proteins were not digested by midgut homogenates of C. maculatus until 8 h of incubation. CaL-1 and CaL-2 ( C. arabica ) and CrL-1 and CrL-2 ( C. racemosa ) are chitin-binding proteins, and their insecticidal properties toward C. maculatus larvae might be related to their capacity to bind chitin present in the larval gut and their associated low digestibility.

ICCE/ICCAI 2000 Full & Short Papers (Computer-Assisted Language Learning).

ERIC Educational Resources Information Center

2000

This document contains the following full and short papers on computer-assisted language learning (CALL) from ICCE/ICCAI 2000 (International Conference on Computers in Education/International Conference on Computer-Assisted Instruction): (1) "A Computer-Assisted English Abstract Words Learning Environment on the Web" (Wenli Tsou and…

Late quaternary changes in lakes, vegetation, and climate in the Bonneville Basin reconstructed from sediment cores from Great Salt Lake: Chapter 11

USGS Publications Warehouse

Thompson, Robert S.; Oviatt, Charles G.; Honke, Jeffrey S.; McGeehin, John

2016-01-01

Sediment cores from Great Salt Lake (GSL) provide the basis for reconstructing changes in lakes, vegetation, and climate for the last ~ 40 cal ka. Initially, the coring site was covered by a shallow saline lake and surrounded by Artemisia steppe or steppe-tundra under a cold and dry climate. As Lake Bonneville began to rise (from ~ 30 to 28 cal ka), Pinus and subalpine conifer pollen percentages increased and Artemisia declined, suggesting the onset of wetter conditions. Lake Bonneville oscillated near the Stansbury shoreline between ~ 26 and ~ 24 cal ka, rose to the Bonneville shoreline by ~ 18 cal ka, and then fell to the Provo shoreline, which it occupied until ~ 15 cal ka. Vegetation changed during this time span, albeit not always with the same direction or amplitude as the lake. The pollen percentages of Pinus and subalpine conifers were high from ~ 25 to 21.5 cal ka, indicating cool and moist conditions during the Stansbury oscillation and for much of the rise toward the Bonneville shoreline. Pinus percentages then decreased and Artemisia became codominant, suggesting drier and perhaps colder conditions from ~ 21 to ~ 15 cal ka, when Lake Bonneville was at or near its highest levels.Lake Bonneville declined to a low level by ~ 13 cal ka, while Pinus pollen percentages increased, indicating that conditions remained cooler and moister than today. During the Younger Dryas interval, the brief Gilbert episode rise in lake level was followed by a shallow lake with a stratified water column. This lake rise occurred as Pinus pollen percentages were declining and those of Artemisia were rising (reflecting increasingly dry conditions), after which Artemisia pollen was at very high levels (suggesting cold and dry conditions) for a brief period.Since ~ 10.6 cal ka lacustrine conditions have resembled those of present-day GSL. Pollen spectra for the period from ~ 10.6 to 7.2 cal ka have low levels of conifer pollen and high (for the Holocene) levels of desert and steppe taxa, suggesting generally dry conditions with maximum aridity occurring prior to the deposition of the Mazama tephra (~ 7.6 cal ka). After ~ 10.6 cal ka, Juniperus pollen percentages began to increase and by ~ 7.2 cal ka juniper woodlands were well established on lower mountain slopes. From ~ 7 to 4 cal ka, pollen percentages fluctuated near their mean values for the entire Holocene. The neopluvial (~ 4 to 2 cal ka) was the wettest part of the Holocene, with higher levels of Juniperus pollen and lower levels for steppe and desert taxa than in older Holocene sediments. Pollen percentages for the last ~ 2 cal ka are variable, but generally indicate a return to drier conditions.

Navy/Marine Corps Manager’s Desktop Guide for CALS Implementation. 2nd Edition

DTIC Science & Technology

1993-06-30

significant process and productivity that CALS initiatives are providing within the Navy infrastructure. CALS programs are on-line and working in today’s Navy...era of declining budgets, CALS is most important in enhancing logistic support productivity to maintain operations and improve readiness. Our...is to be accomplished through the general adoption of a set of procedures and staridards for the production , access, management, maintenance, and

Uncertainty analysis on simple mass balance model to calculate critical loads for soil acidity.

PubMed

Li, Harbin; McNulty, Steven G

2007-10-01

Simple mass balance equations (SMBE) of critical acid loads (CAL) in forest soil were developed to assess potential risks of air pollutants to ecosystems. However, to apply SMBE reliably at large scales, SMBE must be tested for adequacy and uncertainty. Our goal was to provide a detailed analysis of uncertainty in SMBE so that sound strategies for scaling up CAL estimates to the national scale could be developed. Specifically, we wanted to quantify CAL uncertainty under natural variability in 17 model parameters, and determine their relative contributions in predicting CAL. Results indicated that uncertainty in CAL came primarily from components of base cation weathering (BC(w); 49%) and acid neutralizing capacity (46%), whereas the most critical parameters were BC(w) base rate (62%), soil depth (20%), and soil temperature (11%). Thus, improvements in estimates of these factors are crucial to reducing uncertainty and successfully scaling up SMBE for national assessments of CAL.

Computational approach for designing thermostable Candida antarctica lipase B by molecular dynamics simulation.

PubMed

Park, Hyun June; Park, Kyungmoon; Kim, Yong Hwan; Yoo, Young Je

2014-12-20

Candida antarctica lipase B (CalB) is one of the most useful enzyme for various reactions and bioconversions. Enhancing thermostability of CalB is required for industrial applications. In this study, we propose a computational design strategy to improve the thermostability of CalB. Molecular dynamics simulations at various temperatures were used to investigate the common fluctuation sites in CalB, which are considered to be thermally weak points. The RosettaDesign algorithm was used to design the selected residues. The redesigned CalB was simulated to verify both the enhancement of intramolecular interactions and the lowering of the overall root-mean-square deviation (RMSD) values. The A251E mutant designed using this strategy showed a 2.5-fold higher thermostability than the wild-type CalB. This strategy could apply to other industry applicable enzymes. Copyright © 2014 Elsevier B.V. All rights reserved.

Navigation Assistance: A Trade-Off between Wayfinding Support and Configural Learning Support

ERIC Educational Resources Information Center

Munzer, Stefan; Zimmer, Hubert D.; Baus, Jorg

2012-01-01

Current GPS-based mobile navigation assistance systems support wayfinding, but they do not support learning about the spatial configuration of an environment. The present study examined effects of visual presentation modes for navigation assistance on wayfinding accuracy, route learning, and configural learning. Participants (high-school students)…

Perspectives of Introduction of the Mobile-Assisted Language Learning (MALL) Technology

ERIC Educational Resources Information Center

Wagner, Monica-Nataliia Laurensovna; Donskaya, Maryana Vladimirovna; Kupriyanova, Milana Evgenievna; Ovezova, Umeda Akparovna

2016-01-01

Present article addresses methodological and technical (instrumental) aspects of creation and implementation of mobile-assisted learning, which is oriented to the process of foreign languages learning. We provide the interpretation of the main definitions of mobile-assisted learning, as well as propose recommendations for using mobile devices in…

Fire and vegetation history on Santa Rosa Island, Channel Islands, and long-term environmental change in southern California

USGS Publications Warehouse

Starratt, Scott W.; Pinter, N.; Anderson, Robert S.; Jass, R.B.

2009-01-01

The long-term history of vegetation and fire was investigated at two locations – Soledad Pond (275 m; from ca. 12 000 cal. a BP) and Abalone Rocks Marsh (0 m; from ca. 7000 cal. a BP) – on Santa Rosa Island, situated off the coast of southern California. A coastal conifer forest covered highlands of Santa Rosa during the last glacial, but by ca. 11 800 cal. a BP Pinus stands, coastal sage scrub and grassland replaced the forest as the climate warmed. The early Holocene became increasingly drier, particularly after ca. 9150 cal. a BP, as the pond dried frequently, and coastal sage scrub covered the nearby hillslopes. By ca. 6900 cal. a BP grasslands recovered at both sites. Pollen of wetland plants became prominent at Soledad Pond after ca. 4500 cal. a BP, and at Abalone Rocks Marsh after ca. 3465 cal. a BP. Diatoms suggest freshening of the Abalone Rocks Marsh somewhat later, probably by additional runoff from the highlands. Introduction of non-native species by ranchers occurred subsequent to AD 1850. Charcoal influx is high early in the record, but declines during the early Holocene when minimal biomass suggests extended drought. A general increase occurs after ca. 7000 cal. a BP, and especially after ca. 4500 cal. a BP. The Holocene pattern closely resembles population levels constructed from the archaeological record, and suggests a potential influence by humans on the fire regime of the islands, particularly during the late Holocene.

Cabri 3D - assisted collaborative learning to enhance junior high school students’ spatial ability

NASA Astrophysics Data System (ADS)

Muntazhimah; Miatun, A.

2018-01-01

The main purpose of this quasi-experimental study was to determine the enhancement of spatial ability of junior high school students who learned through Cabri-3D assisted collaborative learning. The methodology of this study was the nonequivalent group that was conducted to students of the eighth grade in a junior high school as a population. Samples consisted one class of the experimental group who studied with Cabri-3D assisted collaborative learning and one class as a control group who got regular learning activity. The instrument used in this study was a spatial ability test. Analyzing normalized gain of students’ spatial ability based on mathemathical prior knowledge (MPK) and its interactions was tested by two-way ANOVA at a significance level of 5% then continued with using Post Hoc Scheffe test. The research results showed that there was significant difference in enhancement of the spatial ability between students who learnt with Cabri 3D assisted collaborative learning and students who got regular learning, there was significant difference in enhancement of the spatial ability between students who learnt with cabri 3D assisted collaborative learning and students who got regular learning in terms of MPK and there is no significant interaction between learning (Cabri-3D assisted collaborative learning and regular learning) with students’ MPK (high, medium, and low) toward the enhancement of students’ spatial abilities. From the above findings, it can be seen that cabri-3D assisted collaborative learning could enhance spatial ability of junior high school students.

The Development of a Peer Assisted Learning Model for the Clinical Education of Physiotherapy Students

ERIC Educational Resources Information Center

Sevenhuysen, Samantha L.; Nickson, Wendy; Farlie, Melanie K.; Raitman, Lyn; Keating, Jennifer L.; Molloy, Elizabeth; Skinner, Elizabeth; Maloney, Stephen; Haines, Terry P.

2013-01-01

Demand for clinical placements in physiotherapy education continues to outstrip supply. Peer assisted learning, in various formats, has been trialled to increase training capacity and facilitate student learning during clinical education. There are no documented examples of measurable or repeatable peer assisted learning models to aid clinicians…

Could a Mobile-Assisted Learning System Support Flipped Classrooms for Classical Chinese Learning?

ERIC Educational Resources Information Center

Wang, Y.-H.

2016-01-01

In this study, the researcher aimed to develop a mobile-assisted learning system and to investigate whether it could promote teenage learners' classical Chinese learning through the flipped classroom approach. The researcher first proposed the structure of the Cross-device Mobile-Assisted Classical Chinese (CMACC) system according to the pilot…

Assessing the Effectiveness of Learning Solid Geometry by Using an Augmented Reality-Assisted Learning System

ERIC Educational Resources Information Center

Lin, Hao-Chiang Koong; Chen, Mei-Chi; Chang, Chih-Kai

2015-01-01

This study integrates augmented reality (AR) technology into teaching activities to design a learning system that assists junior high-school students in learning solid geometry. The following issues are addressed: (1) the relationship between achievements in mathematics and performance in spatial perception; (2) whether system-assisted learning…

OSD CALS Architecture Master Plan Study. Concept Paper. Security. Volume 38

DOT National Transportation Integrated Search

1989-07-01

Developing and executing a well-thought-out security policy is critical to the success of CALS. Without appropriate security measures, the integration of technology, organizations, functions, and data envisioned as Phase II CALS can not occur. Theref...

OSD CALS Architecture Master Plan Study. Concept Paper. Configuration Management. Volume 28

DOT National Transportation Integrated Search

1989-10-01

The mission of CALS is to enhance operational readiness of DoD weapon systems through application of information technology to the management of technical information. CALS will automate the current paper-intensive processes involved in weapon system...

Supersaturation of Calcipotriene and Betamethasone Dipropionate in a Novel Aerosol Foam Formulation for Topical Treatment of Psoriasis Provides Enhanced Bioavailability of the Active Ingredients.

PubMed

Lind, Marianne; Nielsen, Kim Troensegaard; Schefe, Line Hollesen; Nørremark, Kasper; Eriksson, André Huss; Norsgaard, Hanne; Pedersen, Brian Thoning; Petersson, Karsten

2016-09-01

Previous studies have demonstrated the superior efficacy of a novel aerosol foam formulation of fixed combination calcipotriene 0.005% (Cal) and betamethasone dipropionate 0.064% (BD), compared with the ointment formulation. The aim of this study is to ascertain whether enhanced bioavailability of the active ingredients due to supersaturation and/or occlusive properties can explain the observed greater clinical efficacy. Solubility and evaporation experiments were conducted to examine the abilities of Cal/BD aerosol foam ingredients to create a supersaturated environment. Optical microscopy, Raman imaging and X-ray powder diffraction were used to examine the physical state of Cal and BD in the formulations after application, and determine whether a supersaturated state remained stable for clinically relevant time periods. In vitro skin penetration and ex vivo biomarker assays were conducted to compare the skin penetration and bioavailability of Cal and BD from the aerosol foam and ointment formulations, respectively. Occlusive properties were examined via transepidermal water loss. Solubility studies showed that Cal and BD solubility increased with increasing dimethyl ether (DME) content. Both active ingredients are completely dissolved in the final aerosol foam formulation. DME rapidly evaporates after spraying, and the amount was reduced to 0.5% of the initial amount after 2 min. This led to the formation of a supersaturated environment, where Cal and BD crystals were absent for at least 26 h after application. Cal/BD aerosol foam had significantly greater in vitro skin penetration and had increased bioavailability compared with Cal/BD ointment. Both formulations effectively occluded the skin. A stable supersaturated solution of Cal/BD in the aerosol foam leads to increased bioavailability and explains the improved clinical effect when compared to the Cal/BD ointment. The studies included in the paper are all conducted by LEO Pharma A/S or CROs on behalf of LEO Pharma A/S.

Cal-Adapt: California's Climate Data Resource and Interactive Toolkit

NASA Astrophysics Data System (ADS)

Thomas, N.; Mukhtyar, S.; Wilhelm, S.; Galey, B.; Lehmer, E.

2016-12-01

Cal-Adapt is a web-based application that provides an interactive toolkit and information clearinghouse to help agencies, communities, local planners, resource managers, and the public understand climate change risks and impacts at the local level. The website offers interactive, visually compelling, and useful data visualization tools that show how climate change might affect California using downscaled continental climate data. Cal-Adapt is supporting California's Fourth Climate Change Assessment through providing access to the wealth of modeled and observed data and adaption-related information produced by California's scientific community. The site has been developed by UC Berkeley's Geospatial Innovation Facility (GIF) in collaboration with the California Energy Commission's (CEC) Research Program. The Cal-Adapt website allows decision makers, scientists and residents of California to turn research results and climate projections into effective adaptation decisions and policies. Since its release to the public in June 2011, Cal-Adapt has been visited by more than 94,000 unique visitors from over 180 countries, all 50 U.S. states, and 689 California localities. We will present several key visualizations that have been employed by Cal-Adapt's users to support their efforts to understand local impacts of climate change, indicate the breadth of data available, and delineate specific use cases. Recently, CEC and GIF have been developing and releasing Cal-Adapt 2.0, which includes updates and enhancements that are increasing its ease of use, information value, visualization tools, and data accessibility. We showcase how Cal-Adapt is evolving in response to feedback from a variety of sources to present finer-resolution downscaled data, and offer an open API that allows other organization to access Cal-Adapt climate data and build domain specific visualization and planning tools. Through a combination of locally relevant information, visualization tools, and access to primary data, Cal-Adapt allows users to investigate how the climate is projected to change in their areas of interest.

Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction.

PubMed

Sanaei, Maryam; Banasiri, Mohammad; Shafiee, Gita; Rostami, Mahsa; Alizad, Saba; Ebrahimi, Mehdi; Larijani, Bagher; Heshmat, Ramin

2015-01-01

The objective of this study was to assess side effects and satisfaction about OsteoCalVitFort (500 mg calcium and 400 I.U. of vitamin D3) usage. A total 186 people were participated with range age from 18 to 65 years old. Each participant received 1 pack that contains 60 OsteoCalVitFort tablet and used two tablet OsteoCalVitFort daily (1 tablet after breakfast and 1 after dinner). By a phone call, side effects and satisfaction about OsteoCalVitFort were assessed. The rate of constipating (8.0 %) and bloating (12.5 %) were decreased significantly after OsteoCalVitFort supplement intake (1.2 %, and 0.6 %, respectively). Similar results were observed in metallic taste in mouth, tiredness, weakness, loss of appetite, bone/muscle pain and mental/mood change after Calcium Vitamin D3 supplementation intake. Totally, 94 % of patients were satisfied about OsteoCalVitFort usage. The results of the research indicate despite the high quality of OsteoCalVitFort supplement, there are no side effects which have been seen in other supplements.

Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons.

PubMed

van Rooijen, Stefanus J; Jongen, Audrey Chm; Wu, Zhou-Qiao; Ji, Jia-Fu; Slooter, Gerrit D; Roumen, Rudi Mh; Bouvy, Nicole D

2017-09-07

To determine the level of consensus on the definition of colorectal anastomotic leakage (CAL) among Dutch and Chinese colorectal surgeons. Dutch and Chinese colorectal surgeons were asked to partake in an online questionnaire. Consensus in the online questionnaire was defined as > 80% agreement between respondents on various statements regarding a general definition of CAL, and regarding clinical and radiological diagnosis of the complication. Fifty-nine Dutch and 202 Chinese dedicated colorectal surgeons participated in the online survey. Consensus was found on only one of the proposed elements of a general definition of CAL in both countries: 'extravasation of contrast medium after rectal enema on a CT scan'. Another two were found relevant according to Dutch surgeons: 'necrosis of the anastomosis found during reoperation', and 'a radiological collection treated with percutaneous drainage'. No consensus was found for all other proposed elements that may be included in a general definition. There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report 'subclinical' leaks as CAL, which partly explains the higher reported Dutch CAL rates.

Robot assistance of motor learning: A neuro-cognitive perspective.

PubMed

Heuer, Herbert; Lüttgen, Jenna

2015-09-01

The last several years have seen a number of approaches to robot assistance of motor learning. Experimental studies have produced a range of findings from beneficial effects through null-effects to detrimental effects of robot assistance. In this review we seek an answer to the question under which conditions which outcomes should be expected. For this purpose we derive tentative predictions based on a classification of learning tasks in terms of the products of learning, the mechanisms involved, and the modulation of these mechanisms by robot assistance. Consistent with these predictions, the learning of dynamic features of trajectories is facilitated and the learning of kinematic and dynamic transformations is impeded by robotic guidance, whereas the learning of dynamic transformations can profit from robot assistance with error-amplifying forces. Deviating from the predictions, learning of spatial features of trajectories is impeded by haptic guidance, but can be facilitated by divergent force fields. The deviations point to the existence of additional effects of robot assistance beyond the modulation of learning mechanisms, e.g., the induction of a passive role of the motor system during practice with haptic guidance. Copyright © 2015 Elsevier Ltd. All rights reserved.

Factors associated with continued participation in a matched monetary incentive programme at local farmers' markets in low-income neighbourhoods in San Diego, California.

PubMed

Ratigan, Amanda R; Lindsay, Suzanne; Lemus, Hector; Chambers, Christina D; Anderson, Cheryl Am; Cronan, Terry A; Browner, Deirdre K; Wooten, Wilma J

2017-10-01

The Farmers' Market Fresh Fund Incentive Program is a policy, systems and environmental intervention to improve access to fresh produce for participants on governmental assistance in the USA. The current study examined factors associated with ongoing participation in this matched monetary incentive programme. Relationship of baseline factors with number of Fresh Fund visits was assessed using Poisson regression. Mixed-effects modelling was used to explore changes in consumption of fruits and vegetables and diet quality. San Diego, California. Recipients of Supplemental Nutrition Assistance Program (SNAP), Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and Supplemental Security Income (SSI) who attended participating farmers' markets from 2010 to 2012 (n 7298). Among those with participation for ≤6 months, factors associated with increased visits included reporting more daily servings of fruits and vegetables (F&V) at baseline, being Vietnamese or Asian/Pacific Islander, and eligibility because of SNAP/CalFresh or SSI (v. WIC). Among those who came for 6-12 months, being Asian/Pacific Islander, eligibility because of SNAP/CalFresh and enrolling in the autumn, winter or spring were associated with a greater number of Fresh Fund visits. Among those who came for >12 months, being male and eligibility because of SSI were associated with a greater number of visits. Overall, the odds of increasing number of servings of F&V consumed increased by 2 % per month, and the odds of improved perception of diet quality increased by 10 % per month. Sustaining and increasing Fresh Fund-type programme operations should be a top priority for future policy decisions concerning farmers' market use in low-income neighbourhoods.

A new bioluminescent reporter system to study the biodistribution of systematically injected tumor-derived bioluminescent extracellular vesicles in mice

PubMed Central

Gangadaran, Prakash; Li, Xiu Juan; Lee, Ho Won; Oh, Ji Min; Kalimuthu, Senthilkumar; Rajendran, Ramya Lakshmi; Son, Seung Hyun; Baek, Se Hwan; Singh, Thoudam Debraj; Zhu, Liya; Jeong, Shin Young; Lee, Sang-Woo; Lee, Jaetae; Ahn, Byeong-Cheol

2017-01-01

In vivo biodistribution and fate of extracellular vesicles (EVs) are still largely unknown and require reliable in vivo tracking techniques. In this study, in vivo bioluminescence imaging (BLI) using Renilla luciferase (Rluc) was developed and applied to monitoring of EVs derived from thyroid cancer (CAL-62 cells) and breast cancer (MDA-MB-231) in nude mice after intravenous administration and was compared with a dye-based labeling method for EV derived from CAL-62 cells. The EVs were successfully labeled with Rluc and visualized by BLI in mice. In vivo distribution of the EVs, as measured by BLI, was consistent with the results of ex vivo organ analysis. EV-CAL-62/Rluc showed strong signals at lung followed by liver, spleen & kidney (P < 0.05). EV-MDA-MB-231/Rluc showed strong signals at liver followed by lung, spleen & kidney (P < 0.05). EV-CAL-62/Rluc and EV-MDA-MB-231/Rluc stayed in animal till day 9 and 3, respectively; showed a differential distribution. Spontaneous EV-CAL-62/Rluc shown distributed mostly to lung followed by liver, spleen & kidney. The new BLI system used to show spontaneous distribution of EV-CAL-62/Rluc in subcutaneous CAL-62/Rluc bearing mice. Dye (DiR)-labeled EV-CAL-62/Rluc showed a different distribution in vivo & ex vivo compared to EV-CAL-62/Rluc. Fluorescent signals were predominately detected in the liver (P < 0.05) and spleen (P < 0.05) regions. The bioluminescent EVs developed in this study may be used for monitoring of EVs in vivo. This novel reporter-imaging approach to visualization of EVs in real time is expected to pave the way for monitoring of EVs in EV-based treatments. PMID:29299117

Transcription Factor Interplay between LEAFY and APETALA1/CAULIFLOWER during Floral Initiation1

PubMed Central

Zheng, Beibei; Kwaśniewska, Kamila; Thomson, Bennett

2017-01-01

The transcription factors LEAFY (LFY) and APETALA1 (AP1), together with the AP1 paralog CAULIFLOWER (CAL), control the onset of flower development in a partially redundant manner. This redundancy is thought to be mediated, at least in part, through the regulation of a shared set of target genes. However, whether these genes are independently or cooperatively regulated by LFY and AP1/CAL is currently unknown. To better understand the regulatory relationship between LFY and AP1/CAL and to obtain deeper insights into the control of floral initiation, we monitored the activity of LFY in the absence of AP1/CAL function. We found that the regulation of several known LFY target genes is unaffected by AP1/CAL perturbation, while others appear to require AP1/CAL activity. Furthermore, we obtained evidence that LFY and AP1/CAL control the expression of some genes in an antagonistic manner. Notably, these include key regulators of floral initiation such as TERMINAL FLOWER1 (TFL1), which had been previously reported to be directly repressed by both LFY and AP1. We show here that TFL1 expression is suppressed by AP1 but promoted by LFY. We further demonstrate that LFY has an inhibitory effect on flower formation in the absence of AP1/CAL activity. We propose that LFY and AP1/CAL act as part of an incoherent feed-forward loop, a network motif where two interconnected pathways or transcription factors act in opposite directions on a target gene, to control the establishment of a stable developmental program for the formation of flowers. PMID:28385730

Transcription Factor Interplay between LEAFY and APETALA1/CAULIFLOWER during Floral Initiation.

PubMed

Goslin, Kevin; Zheng, Beibei; Serrano-Mislata, Antonio; Rae, Liina; Ryan, Patrick T; Kwaśniewska, Kamila; Thomson, Bennett; Ó'Maoiléidigh, Diarmuid S; Madueño, Francisco; Wellmer, Frank; Graciet, Emmanuelle

2017-06-01

The transcription factors LEAFY (LFY) and APETALA1 (AP1), together with the AP1 paralog CAULIFLOWER (CAL), control the onset of flower development in a partially redundant manner. This redundancy is thought to be mediated, at least in part, through the regulation of a shared set of target genes. However, whether these genes are independently or cooperatively regulated by LFY and AP1/CAL is currently unknown. To better understand the regulatory relationship between LFY and AP1/CAL and to obtain deeper insights into the control of floral initiation, we monitored the activity of LFY in the absence of AP1/CAL function. We found that the regulation of several known LFY target genes is unaffected by AP1/CAL perturbation, while others appear to require AP1/CAL activity. Furthermore, we obtained evidence that LFY and AP1/CAL control the expression of some genes in an antagonistic manner. Notably, these include key regulators of floral initiation such as TERMINAL FLOWER1 ( TFL1 ), which had been previously reported to be directly repressed by both LFY and AP1. We show here that TFL1 expression is suppressed by AP1 but promoted by LFY. We further demonstrate that LFY has an inhibitory effect on flower formation in the absence of AP1/CAL activity. We propose that LFY and AP1/CAL act as part of an incoherent feed-forward loop, a network motif where two interconnected pathways or transcription factors act in opposite directions on a target gene, to control the establishment of a stable developmental program for the formation of flowers. © 2017 American Society of Plant Biologists. All Rights Reserved.

CubiCal: Suite for fast radio interferometric calibration

NASA Astrophysics Data System (ADS)

Kenyon, J. S.; Smirnov, O. M.; Grobler, T. L.; Perkins, S. J.

2018-05-01

CubiCal implements several accelerated gain solvers which exploit complex optimization for fast radio interferometric gain calibration. The code can be used for both direction-independent and direction-dependent self-calibration. CubiCal is implemented in Python and Cython, and multiprocessing is fully supported.

CALS Baseline Architecture Analysis of Weapons System. Technical Information: Army, Draft. Volume 8

DOT National Transportation Integrated Search

1989-09-01

This effort was performed to provide a common framework for analysis and planning of CALS initiatives across the military services, leading eventually to the development of a common DoD-wide architecture for CALS. This study addresses Army technical ...

Perspective: Maximum caliber is a general variational principle for dynamical systems

NASA Astrophysics Data System (ADS)

Dixit, Purushottam D.; Wagoner, Jason; Weistuch, Corey; Pressé, Steve; Ghosh, Kingshuk; Dill, Ken A.

2018-01-01

We review here Maximum Caliber (Max Cal), a general variational principle for inferring distributions of paths in dynamical processes and networks. Max Cal is to dynamical trajectories what the principle of maximum entropy is to equilibrium states or stationary populations. In Max Cal, you maximize a path entropy over all possible pathways, subject to dynamical constraints, in order to predict relative path weights. Many well-known relationships of non-equilibrium statistical physics—such as the Green-Kubo fluctuation-dissipation relations, Onsager's reciprocal relations, and Prigogine's minimum entropy production—are limited to near-equilibrium processes. Max Cal is more general. While it can readily derive these results under those limits, Max Cal is also applicable far from equilibrium. We give examples of Max Cal as a method of inference about trajectory distributions from limited data, finding reaction coordinates in bio-molecular simulations, and modeling the complex dynamics of non-thermal systems such as gene regulatory networks or the collective firing of neurons. We also survey its basis in principle and some limitations.

Olfactory Response and Host Plant Feeding of the Central American Locust Schistocerca piceifrons piceifrons Walker to Common Plants in a Gregarious Zone.

PubMed

Poot-Pech, M A; Ruiz-Sánchez, E; Ballina-Gómez, H S; Gamboa-Angulo, M M; Reyes-Ramírez, A

2016-08-01

The Central American locust (CAL) Schistocerca piceifrons piceifrons Walker is one of the most harmful plant pests in the Yucatan Peninsula, where an important gregarious zone is located. The olfactory response and host plant acceptance by the CAL have not been studied in detail thus far. In this work, the olfactory response of the CAL to odor of various plant species was evaluated using an olfactometer test system. In addition, the host plant acceptance was assessed by the consumption of leaf area. Results showed that the CAL was highly attracted to odor of Pisonia aculeata. Evaluation of host plant acceptance showed that the CAL fed on Leucaena glauca and Waltheria americana, but not on P. aculeata or Guazuma ulmifolia. Analysis of leaf thickness, and leaf content of nitrogen (N) and carbon (C) showed that the CAL was attracted to plant species with low leaf C content.

Callose biosynthesis regulates symplastic trafficking during root development.

PubMed

Vatén, Anne; Dettmer, Jan; Wu, Shuang; Stierhof, York-Dieter; Miyashima, Shunsuke; Yadav, Shri Ram; Roberts, Christina J; Campilho, Ana; Bulone, Vincent; Lichtenberger, Raffael; Lehesranta, Satu; Mähönen, Ari Pekka; Kim, Jae-Yean; Jokitalo, Eija; Sauer, Norbert; Scheres, Ben; Nakajima, Keiji; Carlsbecker, Annelie; Gallagher, Kimberly L; Helariutta, Ykä

2011-12-13

Plant cells are connected through plasmodesmata (PD), membrane-lined channels that allow symplastic movement of molecules between cells. However, little is known about the role of PD-mediated signaling during plant morphogenesis. Here, we describe an Arabidopsis gene, CALS3/GSL12. Gain-of-function mutations in CALS3 result in increased accumulation of callose (β-1,3-glucan) at the PD, a decrease in PD aperture, defects in root development, and reduced intercellular trafficking. Enhancement of CALS3 expression during phloem development suppressed loss-of-function mutations in the phloem abundant callose synthase, CALS7 indicating that CALS3 is a bona fide callose synthase. CALS3 alleles allowed us to spatially and temporally control the PD aperture between plant tissues. Using this tool, we are able to show that movement of the transcription factor SHORT-ROOT and microRNA165 between the stele and the endodermis is PD dependent. Taken together, we conclude that regulated callose biosynthesis at PD is essential for cell signaling. Copyright © 2011 Elsevier Inc. All rights reserved.

Heat capacity from 12 to 305°K and entropy of talc and tremolite

USGS Publications Warehouse

Robie, R.A.; Stout, J.W.

1963-01-01

The heat capacities of talc, Mg3Si4O10(OH)2, and tremolite, Ca2Mg6Si8O22(OH)2, have been measured between 12 and 305??K. Smoothed values of heat capacity, entropy, enthalpy, and free energy are tabulated. At 298.15?? K. the values of the thermodynamic functions are: talc, Cp?? = 76.89 ?? 0.23 cal. deg.-1 mole-1, S?? = 62.33 ?? 0.19 cal. deg.-1 mole-1, H?? - H6?? = 11,206 ?? 34 cal. mole-1; tremolite, Cp?? = 156.7 ?? 0.6 cal. deg.-1 mole-1, S?? = 131.2 ?? 0.5 cal. deg.-1 mole-1, H?? - H6?? = 23,335 ?? 90 cal. mole-1. From the equilibrium data of Bowen and Tuttle and the entropy of talc, the heat of formation of talc from MgO, SiO2, and H2O (liq.) is calculated to be ??H??f298 = -43.6 ?? 1 kcal.

Perspective: Maximum caliber is a general variational principle for dynamical systems.

PubMed

Dixit, Purushottam D; Wagoner, Jason; Weistuch, Corey; Pressé, Steve; Ghosh, Kingshuk; Dill, Ken A

2018-01-07

We review here Maximum Caliber (Max Cal), a general variational principle for inferring distributions of paths in dynamical processes and networks. Max Cal is to dynamical trajectories what the principle of maximum entropy is to equilibrium states or stationary populations. In Max Cal, you maximize a path entropy over all possible pathways, subject to dynamical constraints, in order to predict relative path weights. Many well-known relationships of non-equilibrium statistical physics-such as the Green-Kubo fluctuation-dissipation relations, Onsager's reciprocal relations, and Prigogine's minimum entropy production-are limited to near-equilibrium processes. Max Cal is more general. While it can readily derive these results under those limits, Max Cal is also applicable far from equilibrium. We give examples of Max Cal as a method of inference about trajectory distributions from limited data, finding reaction coordinates in bio-molecular simulations, and modeling the complex dynamics of non-thermal systems such as gene regulatory networks or the collective firing of neurons. We also survey its basis in principle and some limitations.

ATLAS Tile calorimeter calibration and monitoring systems

NASA Astrophysics Data System (ADS)

Chomont, Arthur; ATLAS Collaboration

2017-11-01

The ATLAS Tile Calorimeter (TileCal) is the central section of the hadronic calorimeter of the ATLAS experiment and provides important information for reconstruction of hadrons, jets, hadronic decays of tau leptons and missing transverse energy. This sampling calorimeter uses steel plates as absorber and scintillating tiles as active medium. The light produced by the passage of charged particles is transmitted by wavelength shifting fibres to photomultiplier tubes (PMTs), located on the outside of the calorimeter. The readout is segmented into about 5000 cells (longitudinally and transversally), each of them being read out by two PMTs in parallel. To calibrate and monitor the stability and performance of each part of the readout chain during the data taking, a set of calibration systems is used. The TileCal calibration system comprises cesium radioactive sources, Laser and charge injection elements, and allows for monitoring and equalization of the calorimeter response at each stage of the signal production, from scintillation light to digitization. Based on LHC Run 1 experience, several calibration systems were improved for Run 2. The lessons learned, the modifications, and the current LHC Run 2 performance are discussed.

The effect of age on anastomotic leakage in colorectal cancer surgery: A population-based study.

PubMed

Zaimi, Ina; Sparreboom, Cloë L; Lingsma, Hester F; Doornebosch, Pascal G; Menon, Anand G; Kleinrensink, Gert-Jan; Jeekel, Johannes; Wouters, Michel W J M; Lange, Johan F

2018-06-07

The aim of this study was to investigate the effect of age on CAL and its associated mortality. Data were derived from the Dutch ColoRectal Audit. All patients undergoing resection for colorectal cancer in the Netherlands between January 2011 and December 2016 were included. Univariable and multivariable logistic regressions were performed to test the effect of age on CAL and its associated mortality. In total, 45 488 patients were included. The incidence of CAL was 6.4% in patients <60 years old, 5.5% in patients 60-69 years old, 5.4% in patients 70-80 years old, and 4.9% in patients ≥80 years old (P < 0.001). Multivariate analysis showed that age was protective for CAL (OR 0.965 per 5 years, 95% CI 0.941-0.985, P < 0.001). Mortality after CAL was 1.3% in patients <60 years old, 4.8% in patients 60-69 years old, 12.3% in patients 70-80 years old, and 27.0% in patients >80 years old (P < 0.001). Older age was associated with mortality following CAL (OR 1.497 per 5 years 95% CI 1.364-1.647, P < 0.001). This population-based study suggests a protective effect of increased age on CAL after colorectal cancer resection. However, older age is strongly associated with mortality after CAL. © 2018 Wiley Periodicals, Inc.

Fond Memories of Cal Council

ERIC Educational Resources Information Center

Minnis, Douglas L.

2015-01-01

This article describes the author's personal involvement in the California Council for the Education of Teachers (Cal Council), beginning in 1960 and spanning four decades, which involved associations with key people in California teacher education and credentialing. The Cal Council was organized for leaders in teacher education from the…

Human likeness: cognitive and affective factors affecting adoption of robot-assisted learning systems

NASA Astrophysics Data System (ADS)

Yoo, Hosun; Kwon, Ohbyung; Lee, Namyeon

2016-07-01

With advances in robot technology, interest in robotic e-learning systems has increased. In some laboratories, experiments are being conducted with humanoid robots as artificial tutors because of their likeness to humans, the rich possibilities of using this type of media, and the multimodal interaction capabilities of these robots. The robot-assisted learning system, a special type of e-learning system, aims to increase the learner's concentration, pleasure, and learning performance dramatically. However, very few empirical studies have examined the effect on learning performance of incorporating humanoid robot technology into e-learning systems or people's willingness to accept or adopt robot-assisted learning systems. In particular, human likeness, the essential characteristic of humanoid robots as compared with conventional e-learning systems, has not been discussed in a theoretical context. Hence, the purpose of this study is to propose a theoretical model to explain the process of adoption of robot-assisted learning systems. In the proposed model, human likeness is conceptualized as a combination of media richness, multimodal interaction capabilities, and para-social relationships; these factors are considered as possible determinants of the degree to which human cognition and affection are related to the adoption of robot-assisted learning systems.

The First Year Experience of a Peer Assisted Learning Program in Two Institutes of Technology in Ireland

ERIC Educational Resources Information Center

Ginty, Carina; Harding, Nuala

2014-01-01

This paper describes a collaborative action research study in which peer assisted learning was deployed simultaneously across a range of disciplines in two institutes of technology in Ireland. The aim of the research was to determine if peer assisted learning enhances the learning experience of first year participants. An action research approach…

Key Players in Inclusion: Are We Meeting the Professional Needs of Learning Support Assistants for Pupils with Complex Needs?

ERIC Educational Resources Information Center

Abbott, Lesley; McConkey, Roy; Dobbins, Michael

2011-01-01

Under the aegis of inclusion, greater numbers of learning support assistants (LSAs) in mainstream and special schools are increasingly required to assist teachers with pupils who have complex needs across the full age range. Because of the numerous and wide-ranging learning difficulties and learning disabilities in addition to sensory impairment,…

Online training delivery in meteorological continued education and training: Eumetcal experiences & plans

NASA Astrophysics Data System (ADS)

Siili, Tero; Haga, Lisa; Neitiniemi-Upola, Leena

2013-04-01

Eumetcal is the Education and Training (E & T) project of EUMETNET - the collaboration organ­isation of European National Meteorological and Hydrological Services (NMHSs) - with emphasis on Computer Assisted Learning (CAL) from the project's inception in 2002. Finnish Meteorological Institute has been assigned to manage the Eumetcal project since the onset of the project's pilot phase. Participat­ing NMHSs cover most of Europe, their number exceeds 20 and the scales and scopes of their in-house E & T activities vary widely. Eumetcal also collaborates with a number of E & T organisations in Europe and worldwide. Eumetcal's target group includes the meteorological staff and E & T personnel of the participant NMHSs; the target group is hence geographically widely distributed. The subject matters covered include not only scientific and technical skills and competencies, but also other types of competen­cies relevant to NMHSs' staff. Eumetcal's goal and task is to supplement the E & T activities of the participants through collabora­tion and networking, both between project participants and with other E & T organisations. The project also utilises Information and Communications Technologies extensively in delivery of E & T events and materials: Eumetcal is a Virtual Training Organisation and emphasises online and blended E & T events. In the last five years the project has organised or contributed to at least 2-4 E & T events per year. This presentation a) gives an overview of the Eumetcal project and its place among meteorological E & T organisations in Europe and globally, as well as b) describes the E & T events the project has delivered or contributed to in the last years and plans to deliver in 2013. Emphasis will be on the online and blended events and lessons learned from designing and implementing these events and the benefits of using online training.

A study: Effect of Students Peer Assisted Learning on Magnetic Field Achievement

NASA Astrophysics Data System (ADS)

Mueanploy, Wannapa

2016-04-01

This study is the case study of Physic II Course for students of Pathumwan Institute of Technology. The purpose of this study is: 1) to develop cooperative learning method of peer assisted learning (PAL), 2) to compare the learning achievement before and after studied magnetic field lesson by cooperative learning method of peer assisted learning. The population was engineering students of Pathumwan Institute of Technology (PIT’s students) who registered Physic II Course during year 2014. The sample used in this study was selected from the 72 students who passed in Physic I Course. The control groups learning magnetic fields by Traditional Method (TM) and experimental groups learning magnetic field by method of peers assisted learning. The students do pretest before the lesson and do post-test after the lesson by 20 items achievement tests of magnetic field. The post-test higher than pretest achievement significantly at 0.01 level.

78 FR 62614 - CalWind Resources, Inc. v. California Independent System Operator Corporation; Notice of Complaint

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL14-4-000] CalWind Resources, Inc. v. California Independent System Operator Corporation; Notice of Complaint Take notice that... 385.206 (2013), CalWind Resources, Inc. (Complainant) filed a formal complaint against California...

Computer-aided acquisition and logistics support (CALS): Concept of Operations for Depot Maintenance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bourgeois, N.C.; Greer, D.K.

1993-04-01

This CALS Concept of Operations for Depot Maintenance provides the foundation strategy and the near term tactical plan for CALS implementation in the depot maintenance environment. The user requirements enumerated and the overarching architecture outlined serve as the primary framework for implementation planning. The seamless integration of depot maintenance business processes and supporting information systems with the emerging global CALS environment will be critical to the efficient realization of depot user's information requirements, and as, such will be a fundamental theme in depot implementations.

Simultaneously achieve soluble expression and biomimetic immobilization of Candida antarctica lipase B by introducing polyamine tags.

PubMed

Zhou, Xiaoxue; Han, Yu; Lv, Zheng; Tian, Xuemei; Li, Han; Xie, Panpan; Zheng, Liangyu

2017-05-10

Polyamine tags fused in Candida antarctica lipase B (CalB) can help achieve high soluble expression of CalB in E. coli and can directly mediate silicification, which leads to rapid formation of a CalB-silica particle complex through a one-step approach. After optimization experiments, the fused lipase CalB tagged with 6-histidine at the N terminal and 10-lysine at the C terminal (6His-CalB-10Lys) is effectively expressed with high solubility (0.1mg/mL) and specific activity (10.1U/mg), and easily cross-linked in silica particles with a high immobilization efficiency of 96.8% and activity recovery of 81.5%. The immobilized lipase 6His-CalB-10Lys exhibits excellent performance at broad temperature ranges, high thermal and storage stabilities, and superior reusability. Michaelis-Menten kinetics indicates that the affinity and enantioselectivity of the free and immobilized 6His-CalB-10Lys toward the substrate are better than that of commercial Novozym 435 in enantioselective resolution of (S)-N-(2-ethyl-6-methylphenyl) alanine ((S)-NEMPA). The strategies described in this paper are useful for the facile expression and construction of diverse enzyme systems with high efficiency and excellent recyclability. Copyright © 2017 Elsevier B.V. All rights reserved.

Postglacial vegetation history of Mitkof Island, Alexander Archipelago, southeastern Alaska

USGS Publications Warehouse

Ager, T.A.; Carrara, P.E.; Smith, Jane L.; Anne, V.; Johnson, J.

2010-01-01

An AMS radiocarbon-dated pollen record from a peat deposit on Mitkof Island, southeastern Alaska provides a vegetation history spanning ∼12,900 cal yr BP to the present. Late Wisconsin glaciers covered the entire island; deglaciation occurred > 15,400 cal yr BP. The earliest known vegetation to develop on the island (∼12,900 cal yr BP) was pine woodland (Pinus contorta) with alder (Alnus), sedges (Cyperaceae) and ferns (Polypodiaceae type). By ∼12,240 cal yr BP, Sitka spruce (Picea sitchensis) began to colonize the island while pine woodland declined. By ∼11,200 cal yr BP, mountain hemlock (Tsuga mertensiana) began to spread across the island. Sitka spruce-mountain hemlock forests dominated the lowland landscapes of the island until ∼10,180 cal yr BP, when western hemlock (Tsuga heterophylla) began to colonize, and soon became the dominant tree species. Rising percentages of pine, sedge, and sphagnum after ∼7100 cal yr BP may reflect an expansion of peat bog habitats as regional climate began to shift to cooler, wetter conditions. A decline in alders at that time suggests that coastal forests had spread into the island's uplands, replacing large areas of alder thickets. Cedars (Chamaecyparis nootkatensis, Thuja plicata) appeared on Mitkof Island during the late Holocene.

Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons

PubMed Central

van Rooijen, Stefanus J; Jongen, Audrey CHM; Wu, Zhou-Qiao; Ji, Jia-Fu; Slooter, Gerrit D; Roumen, Rudi MH; Bouvy, Nicole D

2017-01-01

AIM To determine the level of consensus on the definition of colorectal anastomotic leakage (CAL) among Dutch and Chinese colorectal surgeons. METHODS Dutch and Chinese colorectal surgeons were asked to partake in an online questionnaire. Consensus in the online questionnaire was defined as > 80% agreement between respondents on various statements regarding a general definition of CAL, and regarding clinical and radiological diagnosis of the complication. RESULTS Fifty-nine Dutch and 202 Chinese dedicated colorectal surgeons participated in the online survey. Consensus was found on only one of the proposed elements of a general definition of CAL in both countries: ‘extravasation of contrast medium after rectal enema on a CT scan’. Another two were found relevant according to Dutch surgeons: ‘necrosis of the anastomosis found during reoperation’, and ‘a radiological collection treated with percutaneous drainage’. No consensus was found for all other proposed elements that may be included in a general definition. CONCLUSION There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report ‘subclinical’ leaks as CAL, which partly explains the higher reported Dutch CAL rates. PMID:28970733

Postglacial vegetation history of Mitkof Island, Alexander Archipelago, southeastern Alaska

NASA Astrophysics Data System (ADS)

Ager, Thomas A.; Carrara, Paul E.; Smith, Jane L.; Anne, Victoria; Johnson, Joni

2010-03-01

An AMS radiocarbon-dated pollen record from a peat deposit on Mitkof Island, southeastern Alaska provides a vegetation history spanning ˜12,900 cal yr BP to the present. Late Wisconsin glaciers covered the entire island; deglaciation occurred > 15,400 cal yr BP. The earliest known vegetation to develop on the island (˜12,900 cal yr BP) was pine woodland ( Pinus contorta) with alder ( Alnus), sedges (Cyperaceae) and ferns (Polypodiaceae type). By ˜12,240 cal yr BP, Sitka spruce ( Picea sitchensis) began to colonize the island while pine woodland declined. By ˜11,200 cal yr BP, mountain hemlock ( Tsuga mertensiana) began to spread across the island. Sitka spruce-mountain hemlock forests dominated the lowland landscapes of the island until ˜10,180 cal yr BP, when western hemlock ( Tsuga heterophylla) began to colonize, and soon became the dominant tree species. Rising percentages of pine, sedge, and sphagnum after ˜7100 cal yr BP may reflect an expansion of peat bog habitats as regional climate began to shift to cooler, wetter conditions. A decline in alders at that time suggests that coastal forests had spread into the island's uplands, replacing large areas of alder thickets. Cedars ( Chamaecyparis nootkatensis, Thuja plicata) appeared on Mitkof Island during the late Holocene.

How ion properties determine the stability of a lipase enzyme in ionic liquids: a molecular dynamics study.

PubMed

Klähn, Marco; Lim, Geraldine S; Wu, Ping

2011-11-07

The influence of eight different ionic liquid (IL) solvents on the stability of the lipase Candida antarctica lipase B (CAL-B) is investigated with molecular dynamics (MD) simulations. Considered ILs contain cations that are based either on imidazolium or guanidinium as well as nitrate, tetrafluoroborate or hexafluorophosphate anions. Partial unfolding of CAL-B is observed during high-temperature MD simulations and related changes of CAL-B regarding its radius of gyration, surface area, secondary structure, amount of solvent close to the backbone and interaction strength with the ILs are evaluated. CAL-B stability is influenced primarily by anions in the order NO(3)(-)≪ BF(4)(-) < PF(6)(-) of increasing stability, which agrees with experiments. Cations influence protein stability less than anions but still substantially. Long decyl side chains, polar methoxy groups and guanidinium-based cations destabilize CAL-B more than short methyl groups, other non-polar groups and imidazolium-based cations, respectively. Two distinct causes for CAL-B destabilization are identified: a destabilization of the protein surface is facilitated mostly by strong Coulomb interactions of CAL-B with anions that exhibit a localized charge and strong polarization as well as with polar cation groups. Surface instability is characterized by an unraveling of α-helices and an increase of surface area, radius of gyration and protein-IL total interaction strength of CAL-B, all of which describe a destabilization of the folded protein state. On the other hand, a destabilization of the protein core is facilitated when direct core-IL interactions are feasible. This is the case when long alkyl chains are involved or when particularly hydrophobic ILs induce major conformational changes that enable ILs direct access to the protein core. This core instability is characterized by a disintegration of β-sheets, diffusion of ions into CAL-B and increasing protein-IL van der Waals interactions. This process describes a stabilization of the unfolded protein state. Both of these processes reduce the folding free energy and thus destabilize CAL-B. The results of this work clarify the impact of ions on CAL-B stabilization. An extrapolation of the observed trends enables proposing novel ILs in which protein stability could be enhanced further. This journal is © the Owner Societies 2011

On the Effectiveness of Robot-Assisted Language Learning

ERIC Educational Resources Information Center

Lee, Sungjin; Noh, Hyungjong; Lee, Jonghoon; Lee, Kyusong; Lee, Gary Geunbae; Sagong, Seongdae; Kim, Munsang

2011-01-01

This study introduces the educational assistant robots that we developed for foreign language learning and explores the effectiveness of robot-assisted language learning (RALL) which is in its early stages. To achieve this purpose, a course was designed in which students have meaningful interactions with intelligent robots in an immersive…

Task-Oriented Internet Assisted English Teaching and Learning in Colleges

ERIC Educational Resources Information Center

Zhang, Juwu

2014-01-01

Task-Oriented Internet Assisted English Teaching and Learning (TIAETL) is a new English teaching and learning model which integrates the Internet-assisted and task-oriented teaching. This article analyzed the worldwide tendency of English teaching and prerequisites for TIAETL in colleges. The TIAETL has the following advantages:…

Computer Assisted Learning in Numeracy.

ERIC Educational Resources Information Center

Hollin, Freda

Computer-assisted learning in numeracy for adults is far less developed than computer-assisted learning in literacy. Although a great many software programs exist, few are suitable for adults and many offer only drill and practice exercises instead of teaching genuine computer skills. One approach instructors can take is to have their students use…

On the different roles of anions and cations in the solvation of enzymes in ionic liquids.

PubMed

Klähn, Marco; Lim, Geraldine S; Seduraman, Abirami; Wu, Ping

2011-01-28

The solvation of the enzyme Candida antarctica lipase B (CAL-B) was studied in eight different ionic liquids (ILs). The influence of enzyme-ion interactions on the solvation of CAL-B and the structure of the enzyme-IL interface are analyzed. CAL-B and ILs are described with molecular dynamics (MD) simulations in combination with an atomistic empirical force field. The considered cations are based on imidazolium or guanidinium that are paired with nitrate, tetrafluoroborate or hexafluorophosphate anions. The interactions of CAL-B with ILs are dominated by Coulomb interactions with anions, while the second largest contribution stems from van der Waals interactions with cations. The enzyme-ion interaction strength is determined by the ion size and the magnitude of the ion surface charge. The solvation of CAL-B in ILs is unfavorable compared to water because of large formation energies for the CAL-B solute cages in ILs. The internal energy in the IL and of CAL-B increases linearly with the enzyme-ion interaction strength. The average electrostatic potential on the surface of CAL-B is larger in ILs than in water, due to a weaker screening of charged enzyme residues. Ion densities increased moderately in the vicinity of charged residues and decreased close to non-polar residues. An aggregation of long alkyl chains close to non-polar regions and the active site entrance of CAL-B are observed in one IL that involved long non-polar decyl groups. In ILs that contain 1-butyl-3-methylimidazolium cations, the diffusion of one or two cations into the active site of CAL-B occurs during MD simulations. This suggests a possible obstruction of the active site in these ILs. Overall, the results indicate that small ions lead to a stronger electrostatic screening within the solvent and stronger interactions with the enzyme. Also a large ion surface charge, when more hydrophilic ions are used, increases enzyme-IL interactions. An increase of these interactions destabilizes the enzyme and impedes enzyme solvation due to an increase in solute cage formation energies.

CAMPARE and Cal-Bridge: Two Institutional Networks Increasing Diversity in Astronomy

NASA Astrophysics Data System (ADS)

Rudolph, Alexander L.; Smecker-Hane, Tammy A.

2017-01-01

We describe two programs, CAMPARE and Cal-Bridge, with the common mission of increasing participation of groups traditionally underrepresented in astronomy, through summer research opportunities, in the case of CAMPARE, scholarships in the case of Cal-Bridge, and significant mentoring in both programs, creating a national impact on their numbers successfully pursuing a PhD in the field.In 7 years, the CAMPARE program has sent 80 students, >80% from underrepresented groups, to conduct summer research at one of 14 major research institutions throughout the country. The graduation rate among CAMPARE scholars is 98%, and of the CAMPARE scholars who have graduated with a Bachelor’s degree, more than 60% have completed or are pursuing graduate education in astronomy or a related field, at institutions including UCLA, UC Riverside, UC Irvine, UC Santa Barbara, USC, Stanford, Univ. of Arizona, Univ. of Washington, and the Fisk-Vanderbilt Master’s-to-PhD program.Now entering its third year, the Cal-Bridge program is a CSU-UC Bridge program comprised of over 75 physics and astronomy faculty from 5 University of California (UC), 9 California State University (CSU), and 14 California Community College (CCC) campuses in Southern California. In the first three years, 22 Cal-Bridge Scholars have been selected, including 11 Hispanic, 3 African-American and 8 female students, 5 of whom are from URM groups. Nineteen (19) of the 22 Cal-Bridge Scholars are first-generation college students. The entire first cohort of 4 Cal-Bridge scholars was accepted to one or more PhD programs in astronomy or physics, including UC Irvine, UC Santa Cruz, UC Davis, Michigan State, and Georgia State Universities. The second cohort of 8 Cal-Bridge scholars is applying to graduate schools this fall.Cal-Bridge provides much deeper mentoring and professional development experiences over the last two years of undergraduate and first year of graduate school to students from this diverse network of higher education institutions. Cal-Bridge Scholars benefit from substantial financial support, intensive, joint mentoring by CSU and UC faculty, professional development workshops, and exposure to research opportunities at the participating UC campuses.

A 6900-year history of landscape modification by humans in lowland Amazonia

NASA Astrophysics Data System (ADS)

Bush, M. B.; Correa-Metrio, A.; McMichael, C. H.; Sully, S.; Shadik, C. R.; Valencia, B. G.; Guilderson, T.; Steinitz-Kannan, M.; Overpeck, J. T.

2016-06-01

A sedimentary record from the Peruvian Amazon provided evidence of climate and vegetation change for the last 6900 years. Piston cores collected from the center of Lake Sauce, a 20 m deep lake at 600 m elevation, were 19.7 m in length. The fossil pollen record showed a continuously forested catchment within the period of the record, although substantial changes in forest composition were apparent. Fossil charcoal, found throughout the record, was probably associated with humans setting fires. Two fires, at c. 6700 cal BP and 4270 cal BP, appear to have been stand-replacing events possibly associated with megadroughts. The fire event at 4270 cal BP followed a drought that caused lowered lake levels for several centuries. The successional trajectories of forest recovery following these large fires were prolonged by smaller fire events. Fossil pollen of Zea mays (cultivated maize) provided evidence of agricultural activity at the site since c. 6320 cal BP. About 5150 years ago, the lake deepened and started to deposit laminated sediments. Maize agriculture reached a peak of intensity between c. 3380 and 700 cal BP. Fossil diatom data provided a proxy for lake nutrient status and productivity, both of which peaked during the period of maize cultivation. A marked change in land use was evident after c. 700 cal BP when maize agriculture was apparently abandoned at this site. Iriartea, a hyperdominant of riparian settings in western Amazonia, increased in abundance within the last 1100 years, but declined markedly at c. 1070 cal BP and again between c. 80 and -10 cal BP.

Pollen record of the mid- to late-Holocene centennial climate change on the East coast of South Korea and its influential factors

NASA Astrophysics Data System (ADS)

Song, Bing; Yi, Sangheon; Jia, Hongjuan; Nahm, Wook-Hyun; Kim, Jin-Cheul; Lim, Jaesoo; Lee, Jin-Young; Sha, Longbin; Mao, Limi; Yang, Zhongyong; Nakanishi, Toshimichi; Hong, Wan; Li, Zhen

2018-01-01

To understand historical climate change in western Pacific coastal areas, a sediment core (SOJ-2) from the stable sedimentary environment of the Songjiho Lagoon on the east coast of South Korea was obtained for centennial-resolution palynological analysis. The ages of the SOJ-2 core is well controlled by carbon 14 dating with high-resolution accelerator mass spectrometry (AMS), and the results indicated a general warm to cold climate trend from the mid-Holocene to the present, which can be divided into two different stages: a warmer stage between 6842 and 1297 cal yr BP and a colder stage from 1297 cal yr BP to the present, with fluctuations during these stages. The climate was wetter from 6842 to 6227 cal yr BP and 4520 to 1297 cal yr BP and was drier from 6227 to 4520 cal yr BP. The climate changed to cold and dry during the period from 1297-425 cal yr BP. The impact of human activity on the climate began at approximately 1297 cal yr BP and became pronounced starting in 425 cal yr BP. The general cooling trend may represent a response to decreasing solar insolation; however, the relative dryness or wetness of the climate may have been co-determined by westerlies and the East Asian summer monsoon (EASM). The climate had a teleconnection with the North Atlantic region, resulting from changes in solar activity. Nevertheless, EI Niño-Southern Oscillation (ENSO) activity played an important role in impacting the EASM changes in western Pacific coastal areas.

Multiple Café au Lait Spots in a Group of Fair-Skinned Children without Signs or Symptoms of Neurofibromatosis Type 1.

PubMed

St John, Jessica; Summe, Heather; Csikesz, Courtney; Wiss, Karen; Hay, Beverly; Belazarian, Leah

2016-09-01

The presence of six or more café au lait (CAL) spots is a criterion for the diagnosis of neurofibromatosis type 1 (NF-1). Children with multiple CAL spots are often referred to dermatologists for NF-1 screening. The objective of this case series is to characterize a subset of fair-complected children with red or blond hair and multiple feathery CAL spots who did not meet the criteria for NF-1 at the time of their last evaluation. We conducted a chart review of eight patients seen in our pediatric dermatology clinic who were previously identified as having multiple CAL spots and no other signs or symptoms of NF-1. We describe eight patients ages 2 to 9 years old with multiple, irregular CAL spots with feathery borders and no other signs or symptoms of NF-1. Most of these patients had red or blond hair and were fair complected. All patients were evaluated in our pediatric dermatology clinic, some with a geneticist. The number of CAL spots per patient ranged from 5 to 15 (mean 9.4, median 9). A subset of children, many with fair complexions and red or blond hair, has an increased number of feathery CAL spots and appears unlikely to develop NF-1, although genetic testing was not conducted. It is important to recognize the benign nature of CAL spots in these patients so that appropriate screening and follow-up recommendations may be made. © 2016 Wiley Periodicals, Inc.

Chronostratigraphy in karst records from the Epipaleolithic to the Mid/Early Neolithic (c. 13.0-6.0 cal ka BP) in the Catalan Coastal Ranges of NE Iberia: environmental changes, sedimentary processes and human activity

NASA Astrophysics Data System (ADS)

Bergadà, M. Mercè; Cervelló, Josep M.; Edo, Manel; Cebrià, Artur; Oms, F. Xavier; Martínez, Pablo; Antolín, Ferran; Morales, Juan Ignacio; Pedro, Mireia

2018-03-01

The stratigraphic, sedimentary and palaeoenvironmental features reflected in cavities in the Catalan Coastal Ranges of NE Iberia (Can Sadurní and Guineu caves) characterize the periods of pronounced climatic and human complexity that occurred c. 13.0-6.0 cal ka BP. This includes the stages of the Younger Dryas and Mid/Early Holocene, the latter being one of the periods of so-called Rapid Climatic Changes (RCCs). These caves, like others in Mediterranean contexts, are the result of an old duct originating in the saturated zone of the karst system and open to the outside; recording a succession of different detrital and anthropic episodes of the Epipaleolithic, Mesolithic and Neolithic communities. From this study it can be seen that paleoclimatic events do not always present clear signals in the karst records, especially c. 12.7-7.4 cal ka BP, corresponding to the Epipaleolithic and Mesolithic. It is characterized by a stratigraphic discontinuity in which there are phases with predominantly detrital sedimentation alternating with hiatus intervals. Detrital sedimentation formed by fine material colluvium with gravitational movements or solifluction processes in fresh and humid conditions. It appears in the following chronological intervals: 12.7-12.2 cal ka BP, 11.5/11.1-10.7/10.4 cal ka BP and 8.2-8.0 cal ka BP (less humid). Hiatus phases are represented in the rest of the sequence up to c. 7.4 cal ka BP. From the sedimentary point of view these stages of hiatus are indicative of phases of stability or lack of episodes with seasonal contrasts; a fact that would cause interruptions to detrital deposition in the interior of the caves. In contrast, in the period c. 7.4 to 6.0 cal ka BP, attributed to the Middle and Early Neolithic, there is a certain stratigraphic continuity. From the sedimentary point of view it is distinguished by a variability of processes that responds to accumulative episodes of short duration characteristic of morphogenesis of the slopes in an arid Mediterranean environment, identified in our records as RCCs, (c. 7.4-7.2 cal ka BP- Cardial Neolithic; c. 6.8-6.3 cal ka BP-Early Postcardial Middle Neolithic and c. 6.2-5.7 cal ka BP- Late Postcardial Middle Neolithic) alternating with episodes of stability, more humid and coinciding with a better sedimentary record of the pastoral activity in the cavities during Epicardial and Late Cardial Neolithic (c. 7.1-6.7 cal ka BP) and Postcardial Middle Neolithic (c. 6.6-5.9 cal ka BP). It is during this period that Holocene climate variability has better resolution in caves in the Catalan Coastal Ranges of NE Iberia.

Holocene multidecadal and multicentennial droughts affecting Northern California and Nevada

USGS Publications Warehouse

Benson, L.; Kashgarian, Michaele; Rye, R.; Lund, S.; Paillet, F.; Smoot, J.; Kester, C.; Mensing, S.; Meko, D.; Lindstrom, S.

2002-01-01

Continuous, high-resolution ??18O records from cored sediments of Pyramid Lake, Nevada, indicate that oscillations in the hydrologic balance occurred, on average, about every 150 years (yr) during the past 7630 calendar years (cal yr). The records are not stationary; during the past 2740 yr, drought durations ranged from 20 to 100 yr and intervals between droughts ranged from 80 to 230 yr. Comparison of tree-ring-based reconstructions of climate change for the past 1200 yr from the Sierra Nevada and the El alpais region of northwest New Mexico indicates that severe droughts associated with Anasazi withdrawal from Chaco Canyon at 820 cal yr BP (calendar years before present) and final abandonment of Chaco Canyon, Mesa Verde, and the Kayenta area at 650 cal yr BP may have impacted much of the western United States.During the middle Holocene (informally defined in this paper as extending from 8000 to 3000 cal yr BP), magnetic susceptibility values of sediments deposited in Pyramid Lake's deep basin were much larger than late-Holocene (3000-0 cal yr BP) values, indicating the presence of a shallow lake. In addition, the mean ?? 18O value of CaCO3 precipitated between 6500 and 3430 cal yr BP was 1.6??? less than the mean value of CaCO3 precipitated after 2740 cal yr BP. Numerical calculations indicate that the shift in the ??18O baseline probably resulted from a transition to a wetter (> 30%) and cooler (3-5??C) climate. The existence of a relatively dry and warm middle-Holocene climate in the Truckee River - Pyramid Lake system is generally consistent with archeological, sedimentological, chemical, physical, and biological records from various sites within the Great Basin of the western United States. Two high-resolution Holocene-climate records are now available from the Pyramid and Owens lake basins which suggest that the Holocene was characterized by five climatic intervals. TIC and ??18O records from Owens Lake indicate that the first interval in the early Holocene (11,600-10,000 cal yr BP) was characterized by a drying trend that was interrupted by a brief (200 yr) wet oscillation centered at 10,300 cal yr BP. This was followed by a second early-Holocene interval (10,000-8000 cal yr BP) during which relatively wet conditions prevailed. During the early part of the middle Holocene (8000-6500 cal yr BP), high-amplitude oscillations in TIC in Owens Lake and ??18O in Pyramid Lake indicate the presence of shallow lakes in both basins. During the latter part of the middle Holocene (6500-3800 cal yr BP), drought conditions dominated, Owens Lake desiccated, and Lake Tahoe ceased spilling to the Truckee River, causing Pyramid Lake to decline. At the beginning of the late Holocene (???3000 cal yr BP), Lake Tahoe rose to its sill level and Pyramid Lake increased in volume. ?? 2002 Elsevier Science Ltd. All rights reserved.

21,000 years of Ethiopian African monsoon variability recorded in sediments of the western Nile deep-sea fan: impact of the Nile freshwater inflow for the Mediterranean thermo-haline circulation

NASA Astrophysics Data System (ADS)

Revel, Marie; Colin, Christophe; Bernasconi, Stephano; Combourieu-Nebout, Nathalie; Ducassou, Emmanuelle; Rolland, Yann; Bosch, Delphine

2014-05-01

The Nile delta sedimentation constitutes a continuous high resolution (1.6 mm/year) record of Ethiopian African monsoon regime intensity. Multiproxy analyses performed on core MS27PT recovered in hemipelagic Nile sediment margin (<90 km outward of the Rosetta mouth of the Nile) allow the quantification of the Saharan aeolian dust and the Blue/White Nile River suspended matter frequency fluctuations during the last 21 cal. ka BP. The radiogenic Sr and Nd isotopes, clay mineralogy, bulk elemental composition and palynological analyses reveal large changes in source components, oscillating between a dominant aeolian Saharan contribution during the LGM and the Late Holocene (~4 to 2 cal. ka BP), a dominant Blue/Atbara Nile River contribution during the early Holocene (15 to 8.4 cal. ka BP) and a probable White Nile River contribution during the Middle Holocene (8.4 to 4 cal. ka BP). The following main features are highlighted: 1. The rapid shift from the LGM arid conditions to the African Humid Period (AHP) started at about 15 cal. ka BP. AHP extends until 8.4 cal. ka BP, and we suggest that the Ethiopian African Monsoon maximum between 12 and 8 cal. ka BP is responsible for a larger Blue/Atbara Nile sediment load and freshwater input into the Eastern Mediterranean Sea. 2. The transition between the AHP and the arid Late Holocene is gradual and occurs in two main phases between 8.4 and 6.5 cal. ka BP and 6.5 to 3.2 cal. ka BP. We suggest that the main rain belt shifted southward from 8.4 to ~4 cal. ka BP and was responsible for progressively reduced sediment load and freshwater input into the eastern Mediterranean Sea. 3. The aridification along the Nile catchments occurred from ~4 to 2 cal. ka BP. A dry period, which culminates at 3.2 cal. ka BP, and seems to coincide with a re-establishment of increased oceanic primary productivity in the western Mediterranean Sea. We postulate that the decrease in thermo-haline water Mediterranean circulation could be part of a response to huge volumes of fresh-water delivered principally by the Nile River from 12 to 8.4 cal. ka BP in the eastern Mediterranean. We propose that the large hydrological change in Ethiopian latitude could be a trigger for the 8.2 ka cooling event recorded in high latitude. Revel R., Colin C., Bernasconi S., Combourieu-Nebout N., Ducassou E., Grousset F.E., Rolland Y., Migeon S., Brunet P., Zhaa Y., Bosch D., Mascle J.,. "21,000 years of Ethiopian African moonsoon variability recorded in sediments of the western Nile deep sea fan", Regional Environmental Change, in press.

Holocene multidecadal and multicentennial droughts affecting Northern California and Nevada

NASA Astrophysics Data System (ADS)

Benson, Larry; Kashgarian, Michaele; Rye, Robert; Lund, Steve; Paillet, Fred; Smoot, Joseph; Kester, Cynthia; Mensing, Scott; Meko, Dave; Lindström, Susan

2002-02-01

Continuous, high-resolution δ18O records from cored sediments of Pyramid Lake, Nevada, indicate that oscillations in the hydrologic balance occurred, on average, about every 150 years (yr) during the past 7630 calendar years (cal yr). The records are not stationary; during the past 2740 yr, drought durations ranged from 20 to 100 yr and intervals between droughts ranged from 80 to 230 yr. Comparison of tree-ring-based reconstructions of climate change for the past 1200 yr from the Sierra Nevada and the El Malpais region of northwest New Mexico indicates that severe droughts associated with Anasazi withdrawal from Chaco Canyon at 820 cal yr BP (calendar years before present) and final abandonment of Chaco Canyon, Mesa Verde, and the Kayenta area at 650 cal yr BP may have impacted much of the western United States.During the middle Holocene (informally defined in this paper as extending from 8000 to 3000 cal yr BP), magnetic susceptibility values of sediments deposited in Pyramid Lake's deep basin were much larger than late-Holocene (3000-0 cal yr BP) values, indicating the presence of a shallow lake. In addition, the mean δ18O value of CaCO 3 precipitated between 6500 and 3430 cal yr BP was 1.6‰ less than the mean value of CaCO 3 precipitated after 2740 cal yr BP. Numerical calculations indicate that the shift in the δ18O baseline probably resulted from a transition to a wetter (>30%) and cooler (3-5°C) climate. The existence of a relatively dry and warm middle-Holocene climate in the Truckee River-Pyramid Lake system is generally consistent with archeological, sedimentological, chemical, physical, and biological records from various sites within the Great Basin of the western United States. Two high-resolution Holocene-climate records are now available from the Pyramid and Owens lake basins which suggest that the Holocene was characterized by five climatic intervals. TIC and δ18O records from Owens Lake indicate that the first interval in the early Holocene (11,600-10,000 cal yr BP) was characterized by a drying trend that was interrupted by a brief (200 yr) wet oscillation centered at 10,300 cal yr BP. This was followed by a second early-Holocene interval (10,000-8000 cal yr BP) during which relatively wet conditions prevailed. During the early part of the middle Holocene (8000-6500 cal yr BP), high-amplitude oscillations in TIC in Owens Lake and δ18O in Pyramid Lake indicate the presence of shallow lakes in both basins. During the latter part of the middle Holocene (6500-3800 cal yr BP), drought conditions dominated, Owens Lake desiccated, and Lake Tahoe ceased spilling to the Truckee River, causing Pyramid Lake to decline. At the beginning of the late Holocene (˜3000 cal yr BP), Lake Tahoe rose to its sill level and Pyramid Lake increased in volume.

CalNex Observational Data

EPA Pesticide Factsheets

Observations made during the 2010 CalNex measurement campaign. This dataset is associated with the following publication:Woody , M., K. Baker , P. Hayes, J. Jimenez, B. Koo, and H. Pye. Understanding sources of organic aerosol during CalNex-2010 using the CMAQ-VBS. Atmospheric Chemistry and Physics. Copernicus Publications, Katlenburg-Lindau, GERMANY, 16: 4081-4100, (2016).

30 CFR 905.773 - Requirements for permits and permit processing.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 42 U.S.C. 7401 et seq California Air Pollution Control Laws, Cal. Health & Safety Code section 39000... (11) Noise Control Act, 42 U.S.C. 4903 California Noise Control Act of 1973, Cal. Health & Safety Code... Pollution Control Laws, Cal. Health & Safety Code section 39000 et seq.; the Hazardous Waste Control Law...

78 FR 1252 - CalAmp Wireless Networks Corporation (CWNC), Satellite Products Division, Including On-Site...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-08

... Select Staffing, Oxnard, CA; CalAmp Wireless Networks Corporation (CWNC), Including On- Site Leased... Division, including on-site leased workers from Select Staffing, Oxnard, California (TA-W-80,399). The...-site leased workers from Select Staffing, Oxnard, California (TA-W-80,399) and CalAmp Wireless Networks...

Delayed deglaciation or extreme Arctic conditions 21-16 cal. kyr at southeastern Laurentide Ice Sheet margin?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peteet, D. M.; Beh, M.; Orr, C.

The conventionally accepted ages of the Last Glacial Maximum (LGM) retreat of the southeastern Laurentide Ice Sheet (LIS) are 26–21 cal. kyr (derived from bulk-sediment radiocarbon ages) and 28–23 cal. kyr (varve estimates). By utilizing accelerator mass spectrometry (AMS) 14C dating of earliest macrofossils in 13 lake/bog inorganic clays, we find that vegetation first appeared on the landscape at 16–15 cal. kyr, suggesting ice had not retreated until that time. The gap between previous age estimates and ours is significant and has large implications for our understanding of ocean-atmosphere linkages. Older ages imply extreme Arctic conditions for 9–5 cal kyr;more » a landscape with no ice, yet no deposition in lakes. Also, our new AMS chronology of LIS retreat is consistent with marine evidence of deglaciation from the N. Atlantic, showing significant freshwater input and sea level rise only after 19 cal kyr with a cold meltwater lid, perhaps delaying ice melt.« less

Delayed deglaciation or extreme Arctic conditions 21-16 cal. kyr at southeastern Laurentide Ice Sheet margin?

DOE PAGES

Peteet, D. M.; Beh, M.; Orr, C.; ...

2012-06-15

The conventionally accepted ages of the Last Glacial Maximum (LGM) retreat of the southeastern Laurentide Ice Sheet (LIS) are 26–21 cal. kyr (derived from bulk-sediment radiocarbon ages) and 28–23 cal. kyr (varve estimates). By utilizing accelerator mass spectrometry (AMS) 14C dating of earliest macrofossils in 13 lake/bog inorganic clays, we find that vegetation first appeared on the landscape at 16–15 cal. kyr, suggesting ice had not retreated until that time. The gap between previous age estimates and ours is significant and has large implications for our understanding of ocean-atmosphere linkages. Older ages imply extreme Arctic conditions for 9–5 cal kyr;more » a landscape with no ice, yet no deposition in lakes. Also, our new AMS chronology of LIS retreat is consistent with marine evidence of deglaciation from the N. Atlantic, showing significant freshwater input and sea level rise only after 19 cal kyr with a cold meltwater lid, perhaps delaying ice melt.« less

Holocene vegetation change in the northern Peten and its implications for Maya prehistory

NASA Astrophysics Data System (ADS)

Wahl, David; Byrne, Roger; Schreiner, Thomas; Hansen, Richard

2006-05-01

An ˜8400 cal yr record of vegetation change from the northern Peten, Guatemala, provides new insights into the environmental history of the archaeological area known as the Mirador Basin. Pollen, loss on ignition, and magnetic susceptibility analyses indicate warm and humid conditions in the early to mid-Holocene. Evidence for a decrease in forest cover around 4600 cal yr B.P. coincides with the first appearance of Zea mays pollen, suggesting that human activity was responsible. The period between 3450 cal yr B.P. and 1000 cal yr B.P. is characterized by a further decline in forest pollen types, includes an abrupt increase in weedy taxa, and exhibits the highest magnetic susceptibility values since the early Holocene, all of which suggest further agricultural disturbance in the watershed. A brief drop in disturbance indicators around 1800 cal yr B.P. may represent the Preclassic abandonment of the area. Changing pollen frequencies around 1000 cal yr B.P. indicate a cessation of human disturbance, which represents the Late Classic collapse of the southern Maya lowlands.

Computers in medical education 1: evaluation of a problem-orientated learning package.

PubMed

Devitt, P; Palmer, E

1998-04-01

A computer-based learning package has been developed, aimed at expanding students' knowledge base, as well as improving data-handling abilities and clinical problem-solving skills. The program was evaluated by monitoring its use by students, canvassing users' opinions and measuring its effectiveness as a learning tool compared to tutorials on the same material. Evaluation was undertaken using three methods: initially, by a questionnaire on computers as a learning tool and the applicability of the content: second, through monitoring by the computer of student use, decisions and performance; finally, through pre- and post-test assessment of fifth-year students who either used a computer package or attended a tutorial on equivalent material. Most students provided positive comments on the learning material and expressed a willingness to see computer-aided learning (CAL) introduced into the curriculum. Over a 3-month period, 26 modules in the program were used on 1246 occasions. Objective measurement showed a significant gain in knowledge, data handling and problem-solving skills. Computer-aided learning is a valuable learning resource that deserves better attention in medical education. When used appropriately, the computer can be an effective learning resource, not only for the delivery of knowledge. but also to help students develop their problem-solving skills.

Learning Tools for Knowledge Nomads: Using Personal Digital Assistants (PDAs) in Web-based Learning Environments.

ERIC Educational Resources Information Center

Loh, Christian Sebastian

2001-01-01

Examines how mobile computers, or personal digital assistants (PDAs), can be used in a Web-based learning environment. Topics include wireless networks on college campuses; online learning; Web-based learning technologies; synchronous and asynchronous communication via the Web; content resources; Web connections; and collaborative learning. (LRW)

An Assistive Computerized Learning Environment for Distance Learning Students with Learning Disabilities

ERIC Educational Resources Information Center

Klemes, Joel; Epstein, Alit; Zuker, Michal; Grinberg, Nira; Ilovitch, Tamar

2006-01-01

The current study examines how a computerized learning environment assists students with learning disabilities (LD) enrolled in a distance learning course at the Open University of Israel. The technology provides computer display of the text, synchronized with auditory output and accompanied by additional computerized study skill tools which…

The Rivalry between Simulation and Problem-Based Learning: A Study of Learning Transfer in Physician Assistant Students

ERIC Educational Resources Information Center

Meyer, Kimberly E.

2010-01-01

The purpose of this dissertation was to evaluate learning transfer achieved by physician assistant students comparing two instructional methods, human patient simulation and electronic clinical case studies. This prospective, randomized, mixed-methods study utilized first and second-year physician assistant student volunteers taking a pretest and…

Improvement of The Ability of Junior High School Students Thinking Through Visual Learning Assisted Geo gbra Tutorial

NASA Astrophysics Data System (ADS)

Elvi, M.; Nurjanah

2017-02-01

This research is distributed on the issue of the lack of visual thinking ability is a must-have basic ability of students in learning geometry. The purpose of this research is to investigate and elucide: 1) the enhancement of visual thinking ability of students to acquire learning assisted with geogebra tutorial learning: 2) the increase in visual thinking ability of students who obtained a model of learning assisted with geogebra and students who obtained a regular study of KAM (high, medium, and low). This research population is grade VII in Bandung Junior High School. The instruments used to collect data in this study consisted of instruments of the test and the observation sheet. The data obtained were analyzed using the test average difference i.e. Test-t and ANOVA Test one line to two lines. The results showed that: 1) the attainment and enhancement of visual thinking ability of students to acquire learning assisted geogebra tutorial better than students who acquire learning; 2) there may be differences of visual upgrade thinking students who acquire the learning model assisted with geogebra tutorial earn regular learning of KAM (high, medium and low).

Vibrio parahaemolyticus CalR down regulates the thermostable direct hemolysin (TDH) gene transcription and thereby inhibits hemolytic activity.

PubMed

Zhang, Yiquan; Zhang, Ying; Gao, He; Zhang, Lingyu; Yin, Zhe; Huang, Xinxiang; Zhou, Dongsheng; Yang, Huiying; Yang, Wenhui; Wang, Li

2017-05-20

TDH, encoded by tdh gene, is a major virulent determinant of V. parahaemolyticus that controls various biological activities, such as hemolytic activity, cytotoxicity, and enterotoxicity. The hemolytic activity on Wagatsuma agar ascribed to TDH is called Kanagawa phenomenon (KP). All KP positive strains contain tdh1 and tdh2 genes, but tdh2 is predominantly responsible for KP. CalR is a regulatory protein that was originally identified as a repressor of swarming motility and T3SS1 gene expression in V. parahaemolyticus. In the present study, the regulation of tdh2 by CalR was investigated using a set of experiments including qRT-PCR, primer extension, LacZ fusion, hemolytic phenotype, EMSA, and DNase I footprinting assays. The results showed that His-CalR protected a single region from 224bp to 318bp upstream of tdh2 against DNase I digestion, and a transcriptional start site located at 42bp upstream of tdh2 was detected and its transcribed activity was inhibited by CalR. Moreover, the KP test results showed that the hemolytic activity of V. parahaemolyticus is also under negative control of CalR. The data demonstrated that CalR is a repressor of the tdh2 transcription and thereby inhibits the hemolytic activity of V. parahaemolyticus. Copyright © 2017. Published by Elsevier B.V.

Vegetation history along the eastern, desert escarpment of the Sierra San Pedro Mártir, Baja California, Mexico

USGS Publications Warehouse

Holmgren, Camille A.; Betancourt, Julio L.; Rylander, Kate A.

2011-01-01

Plant macrofossils from 38 packrat middens spanning the last ~ 33,000 cal yr BP record vegetation between ~ 650 and 900 m elevation along the eastern escarpment of the Sierra San Pedro Mártir, northern Baja California. The middens span most of the Holocene, with a gap between ~ 4600 and 1800 cal yr BP, but coverage in the Pleistocene is uneven with a larger hiatus between 23,100 and 14,400 cal yr BP. The midden flora is relatively stable from the Pleistocene to Holocene. Exceptions include Pinus californiarum, Juniperus californica and other chaparral elements that were most abundant > 23,100 cal yr BP and declined after 14,400 cal yr BP. Despite being near the chaparral/woodland-desertscrub ecotone during glacial times, the midden assemblages reflect none of the climatic reversals evident in the glacial or marine record, and this is corroborated by a nearby semi-continuous pollen stratigraphy from lake sediments. Regular appearance of C4 grasses and summer-flowering annuals since 13,600 cal yr BP indicates occurrence of summer rainfall equivalent to modern (JAS average of ~ 80–90 mm). This casts doubt on the claim, based on temperature proxies from marine sediments in the Guaymas Basin, that monsoonal development in the northern Gulf and Arizona was delayed until after 6200 cal yr BP.

Pre-Calculus California Content Standards: Standards Deconstruction Project. Version 1.0

ERIC Educational Resources Information Center

Arnold, Bruce; Cliffe, Karen; Cubillo, Judy; Kracht, Brenda; Leaf, Abi; Legner, Mary; McGinity, Michelle; Orr, Michael; Rocha, Mario; Ross, Judy; Teegarden, Terrie; Thomson, Sarah; Villero, Geri

2008-01-01

This project was coordinated and funded by the California Partnership for Achieving Student Success (Cal-PASS). Cal-PASS is a data sharing system linking all segments of education. Its purpose is to improve student transition and success from one educational segment to the next. Cal-PASS' standards deconstruction project was initiated by the…

The Role of Calgranulin Overexpression in Breast Cancer Progression

DTIC Science & Technology

2005-09-01

transfected cells. As shown in Figure 4, exposure of MCF-7 cells to 25ng/ml OSM for 24 hours caused a very significant increase in Cal A levels . Interestingly...Cal A expression was not observed in the parental or vector alone cells, but the transfected cells showed an elevation in Cal A levels . The

76 FR 70520 - Rovac Corp., RS Group of Companies, Inc., Rymer Foods, Inc. Stratus Services Group, Inc., Sun Cal...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-14

...., Rymer Foods, Inc. Stratus Services Group, Inc., Sun Cal Energy, Inc., Sun Motor International, Inc... current and accurate information concerning the securities of Sun Cal Energy, Inc. because it has not... Sun Motor International, Inc. because it has not filed any periodic reports since the period ended...

Monitoring Outcomes for Los Angeles County's Pre- and Post-CalWORKS Leavers: How Are They Faring?

ERIC Educational Resources Information Center

Verma, Nandita; Hendra, Richard

The characteristics, earnings, employment experiences, and material well-being of California welfare recipients after leaving welfare were examined by comparing the postwelfare experiences of groups who exited welfare before and after institution of California's welfare reform program CalWORKs. The first group (pre-CalWORKs group) exited welfare…

Blended Learning in Personalized Assistive Learning Environments

ERIC Educational Resources Information Center

Marinagi, Catherine; Skourlas, Christos

2013-01-01

In this paper, the special needs/requirements of disabled students and cost-benefits for applying blended learning in Personalized Educational Learning Environments (PELE) in Higher Education are studied. The authors describe how blended learning can form an attractive and helpful framework for assisting Deaf and Hard-of-Hearing (D-HH) students to…

Design of Intelligent Robot as A Tool for Teaching Media Based on Computer Interactive Learning and Computer Assisted Learning to Improve the Skill of University Student

NASA Astrophysics Data System (ADS)

Zuhrie, M. S.; Basuki, I.; Asto B, I. G. P.; Anifah, L.

2018-01-01

The focus of the research is the teaching module which incorporates manufacturing, planning mechanical designing, controlling system through microprocessor technology and maneuverability of the robot. Computer interactive and computer-assisted learning is strategies that emphasize the use of computers and learning aids (computer assisted learning) in teaching and learning activity. This research applied the 4-D model research and development. The model is suggested by Thiagarajan, et.al (1974). 4-D Model consists of four stages: Define Stage, Design Stage, Develop Stage, and Disseminate Stage. This research was conducted by applying the research design development with an objective to produce a tool of learning in the form of intelligent robot modules and kit based on Computer Interactive Learning and Computer Assisted Learning. From the data of the Indonesia Robot Contest during the period of 2009-2015, it can be seen that the modules that have been developed confirm the fourth stage of the research methods of development; disseminate method. The modules which have been developed for students guide students to produce Intelligent Robot Tool for Teaching Based on Computer Interactive Learning and Computer Assisted Learning. Results of students’ responses also showed a positive feedback to relate to the module of robotics and computer-based interactive learning.

High-resolution foraminiferal, isotopic, and trace element records from holocene estuarine deposits of San Francisco Bay, California

USGS Publications Warehouse

McGann, M.

2008-01-01

A 3.5-m gravity core (DJ6-93SF-6) from San Francisco Bay reveals a complex paleoclimatic history of the region over the last 3870 cal YBP. A polynomial equation based on 11 AMS 14C ages provides an excellent age model for the core, and environmental proxies for water temperature and salinity are derived from various foraminiferal abundances, stable carbon and oxygen isotopes, and Mg/Ca ratios. Two foraminiferal associations were identified by Q-mode cluster analysis: a colder-water Elphidium excavatum association and the warmer-water Ammonia beccarii-Elphidium gunteri association. The E. excavatum association dominates the core for all but about 600 years out of the last four millennia. At 3870 cal YBP, water temperatures were warm (13.9??C) and freshwater inflow was reduced compared with today. From 3590 to 2860 cal YBP, temperatures dropped 0.5??C and the climate remained dry. This was followed by a period of pronounced lower ??13C values, indicating that conditions became considerably wetter from 2860 to 2170 cal YBP. During this interval, the temperature oscillated frequently, peaking at 13.9??C at 2710 cal YBP, then dropping shortly thereafter to 12.8??C at 2420 cal YBP. Freshwater inflow gradually decreased between 2170 and 1950 cal YBP with a minimal rise in temperature, then changed quickly to colder and wetter conditions at 1900 cal YBP. Drier conditions then prevailed until 1480 cal YBP with water temperatures fluctuating between 13.1??C and 13.8??C, followed by wetter climate from 1480 to 1320 cal YBP. A significant faunal shift from the E. excavatum association to the A. beccarii-E. gunteri association occurred from 1250 to 650 cal YBP, possibly due to regional warming, decreased oxygen availability, and/or a change in the phyto-plankton community. Associated with this change in faunal composition were warm and dry conditions, representative of the Medieval Warm Period (Medieval Climatic Anomaly). A climatic shift coincident with the onset of the Little Ice Age (LIA I and LIA II) is evident from 650 to 280 cal YBP, with the return of the E. excavatum association and an extreme drop in ??18O values, all indicating increased precipitation and fresh water inflow. This was followed by generally drier conditions to the present, except for a brief wet period around 100 cal YBP, and fairly consistent water temperatures in the middle 13??C, except for a drop to 12.8??C at 200 cal YBP. Two significant faunal changes occur near the top of the core. First, there is the reappearance of the A. beccarii-E. gunteri association, suggesting that, once again, regional warming has taken place, oxygen availability has declined, and/or environmental conditions changed such that diatoms have become a scarce food source. Second, there is the first appearance of the invasive Japanese foraminifera Trochammina hadai Uchio, a species that commonly lives in highly polluted areas and is an indicator of eutrophication in its native estuaries. At the same time, freshwater inflow decreased, which may be explained by global warming during the last 100 years, or more likely due to modern water diversion for agriculture in the central valley of California. ADDITIONAL INDEX WORDS: Climate, San Francisco Bay, Holocene, foraminifers, isotopes, trace metals, Medieval Warm Period, Little Ice Age.

The Aerosol Foam Formulation of the Fixed Combination Calcipotriene Plus Betamethasone Dipropionate Improves the Health-Related Quality of Life in Patients With Psoriasis Vulgaris: Results from the Randomized PSO-FAST Study.

PubMed

Leonardi, Craig; Bagel, Jerry; Yamauchi, Paul; Pariser, David; Xu, Zhenyi; Moller, Anders; Osterdal, Marie Louise; Stein Gold, Linda

2016-08-01

Psoriasis has a major impact on patient quality of life, similar to that seen in other chronic diseases, eg, diabetes. Health-related quality of life (HRQoL) measures are commonly included in clinical trial designs, capturing the disease burden and therapeutic success of a treatment. In the randomized, double-blind, phase III PSO-FAST (Psoriasis vulgaris, a Four-week, vehicle-controlled, efficacy And Safety Trial) study (nCT01866163), fixed combination calcipotriene (Cal) 0.005% plus betamethasone dipropionate (BD) 0.064% aerosol foam was compared with vehicle. By treatment end, 53% of patients using Cal/BD foam achieved treatment success.
To compare the impact on HRQoL of Cal/BD foam vs vehicle in patients with mild-to-severe psoriasis.
HRQoL was assessed by dermatology life-quality index (DLQI; baseline, weeks 1, 2, 4) and EQ-5D-5L (EQ-5D; baseline, week 4) questionnaires. A DLQI score of 0 (range, 0-30) indicates no effect on the patient's life; an EQ-5D utility score of 1 (range, 0-1) and an EQ-5D visual analog scale (VAS) score of 100 (range, 1-100) indicate perfect health.
426 patients were randomized (Cal/BD foam, n=323; vehicle, n=103). Baseline mean DLQI scores were 9.9 (Cal/BD foam) and 10.3 (vehicle). The impact of psoriasis on HRQoL (EQ-5D utility score) at baseline was primarily driven by pain/discomfort (Cal/BD foam: 69.9%; vehicle: 65.0%) and anxiety/depression (Cal/BD foam: 45.3%; vehicle 44.7%). There was a greater improvement from baseline in DLQI score for Cal/BD foam vs vehicle at week 4 (-7.0 vs -4.4; P<.001); increased improvement was also seen in EQ-5D scores. At week 4, 48.1% of patients using Cal/BD foam reported no effect of psoriasis on their lives (DLQI = 0/1), and of patients using Cal/BD foam with baseline DLQI scores ≥5, 81.2% achieved a ≥5-point improvement.
Cal/BD aerosol foam improved HRQoL after 4 weeks, with most patients experiencing a clinically meaningful improvement and almost 50% reporting no impairment.

J Drugs Dermatol. 2016;15(8):981-987.

Holocene seasonal variability inferred from multiple proxy records from Crevice Lake, Yellowstone National Park, USA

USGS Publications Warehouse

Whitlock, Cathy; Dean, Walter E.; Fritz, Sherilyn C.; Stevens, Lora R.; Stone, Jeffery R.; Power, Mitchell J.; Rosenbaum, Joseph R.; Pierce, Kenneth L.; Bracht-Flyr, Brandi B.

2012-01-01

A 9400-yr-old record from Crevice Lake, a semi-closed alkaline lake in northern Yellowstone National Park, was analyzed for pollen, charcoal, geochemistry, mineralogy, diatoms, and stable isotopes to develop a nuanced understanding of Holocene environmental history in a region of northern Rocky Mountains that receives both summer and winter precipitation. The limited surface area, conical bathymetry, and deep water (> 31 m) of Crevice Lake create oxygen-deficient conditions in the hypolimnion and preserve annually laminated sediment (varves) for much of the record. Pollen data indicate that the watershed supported a closed Pinus-dominated forest and low fire frequency prior to 8200 cal yr BP, followed by open parkland until 2600 cal yr BP, and open mixed-conifer forest thereafter. Fire activity shifted from infrequent stand-replacing fires initially to frequent surface fires in the middle Holocene and stand-replacing events in recent centuries. Low values of δ18O suggest high winter precipitation in the early Holocene, followed by steadily drier conditions after 8500 cal yr BP. Carbonate-rich sediments before 5000 cal yr BP imply warmer summer conditions than after 5000 cal yr BP. High values of molybdenum (Mo), uranium (U), and sulfur (S) indicate anoxic bottom-waters before 8000 cal yr BP, between 4400 and 3900 cal yr BP, and after 2400 cal yr BP. The diatom record indicates extensive water-column mixing in spring and early summer through much of the Holocene, but a period between 2200 and 800 cal yr BP had strong summer stratification, phosphate limitation, and oxygen-deficient bottom waters. Together, the proxy data suggest wet winters, protracted springs, and warm effectively wet summers in the early Holocene and less snowpack, cool springs, warm dry summers in the middle Holocene. In the late Holocene, the region and lake experienced extreme changes in winter, spring, and summer conditions, with particularly short springs and dry summers and winters during the Roman Warm Period (~ 2000 cal yr BP) and Medieval Climate Anomaly (1200–800 cal yr BP). Long springs and mild summers occurred during the Little Ice Age, and these conditions persist to the present. Although the proxy data indicate effectively wet summer conditions in the early Holocene and drier conditions in the middle and late Holocene, none point specifically to changes in summer precipitation as the cause. Instead, summer conditions were governed by multi-seasonal controls on effective moisture that operated over multiple time scales.

Changes in total body bone mineral density following a common bone health plan with two versions of a unique bone health supplement: a comparative effectiveness research study.

PubMed

Michalek, Joel E; Preuss, Harry G; Croft, Harry A; Keith, Patti L; Keith, Samuel C; Dapilmoto, Monika; Perricone, Nicholas V; Leckie, Robert B; Kaats, Gilbert R

2011-04-14

The US Surgeon General's Report on Bone Health suggests America's bone-health is in jeopardy and issued a "call to action" to develop bone-health plans that: (1) improve nutrition, (2) increase health literacy and, (3) increase physical activity. This study is a response to this call to action. After signing an informed consent, 158 adults agreed to follow an open-label bone-health plan for six months after taking a DXA test of bone density, a 43-chemistry blood test panel and a quality of life inventory (AlgaeCal 1). Two weeks after the last subject completed, a second group of 58 was enrolled and followed the identical plan, but with a different bone-health supplement (AlgaeCal 2). There were no significant differences between the two groups in baseline bone mineral density (BMD) or in variables related to BMD (age, sex, weight, percent body fat, fat mass, or fat-free mass). In both groups, no significant differences in BMD or related variables were found between volunteers and non-volunteers or between those who completed per protocol and those who were lost to attrition.Both groups experienced a significant positive mean annualized percent change (MAPC) in BMD compared to expectation [AlgaeCal 1: 1.15%, p = 0.001; AlgaeCal 2: 2.79%, p = 0.001]. Both groups experienced a positive MAPC compared to baseline, but only AlgaeCal 2 experienced a significant change [AlgaeCal 1: 0.48%, p = 0.14; AlgaeCal 2: 2.18%, p < 0.001]. The MAPC in AlgaeCal 2 was significantly greater than that in AlgaeCal 1 (p = 0.005). The MAPC contrast between compliant and partially compliant subjects was significant for both plans (p = 0.001 and p = 0.003 respectively). No clinically significant changes in a 43-panel blood chemistry test were found nor were there any changes in self-reported quality of life in either group. Following The Plan for six months with either version of the bone health supplement was associated with significant increases in BMD as compared to expected and, in AlgaeCal 2, the increase from baseline was significantly greater than the increase from baseline in AlgaeCal 1. Increased compliance was associated with greater increases in BMD in both groups. No adverse effects were reported in either group. ClinicalTrials.gov NCT01114685.

PAS-cal: a Generic Recombinant Peptide Calibration Standard for Mass Spectrometry

NASA Astrophysics Data System (ADS)

Breibeck, Joscha; Serafin, Adam; Reichert, Andreas; Maier, Stefan; Küster, Bernhard; Skerra, Arne

2014-08-01

We describe the design, preparation, and mass-spectrometric characterization of a new recombinant peptide calibration standard with uniform biophysical and ionization characteristics for mass spectrometry. "PAS-cal" is an artificial polypeptide concatamer of peptide cassettes with varying lengths, each composed of the three small, chemically stable amino acids Pro, Ala, and Ser, which are interspersed by Arg residues to allow site-specific cleavage with trypsin. PAS-cal is expressed at high yields in Escherichia coli as a Small Ubiquitin-like MOdifier (SUMO) fusion protein, which is easily purified and allows isolation of the PAS-cal moiety after SUMO protease cleavage. Upon subsequent in situ treatment with trypsin, the PAS-cal polypeptide yields a set of four defined homogeneous peptides in the range from 2 to 8 kDa with equal mass spacing. ESI-MS analysis revealed a conveniently interpretable raw spectrum, which after deconvolution resulted in a very simple pattern of four peaks with similar ionization signals. MALDI-MS analysis of a PAS-cal peptide mixture comprising both the intact polypeptide and its tryptic fragments revealed not only the four standard peptides but also the singly and doubly charged states of the intact concatamer as well as di- and trimeric adduct ion species between the peptides, thus augmenting the observable m/z range. The advantageous properties of PAS-cal are most likely a result of the strongly hydrophilic and conformationally disordered PEG-like properties of the PAS sequences. Therefore, PAS-cal offers an inexpensive and versatile recombinant peptide calibration standard for mass spectrometry in protein/peptide bioanalytics and proteomics research, the composition of which may be further adapted to fit individual needs.

Hot deformation behaviors and processing maps of B{sub 4}C/Al6061 neutron absorber composites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yu-Li

In this study, the hot deformation behaviors of 30 wt.% B{sub 4}C/Al6061 neutron absorber composites (NACs) have been investigated by conducting isothermal compression tests at temperatures ranging from 653 K to 803 K and strain rates from 0.01 to 10 s{sup −1}. It was found that, during hot compression, the B{sub 4}C/Al6061 NACs exhibited a steady flow characteristic which can be expressed by the Zener-Hollomon parameter as a hyperbolic-sine function of flow stress. High average activation energy (185.62 kJ/mol) of B{sub 4}C/Al6061 NACs is noted in current study owing to the high content of B{sub 4}C particle. The optimum hotmore » working conditions for B{sub 4}C/Al6061 NACs are found to be 760–803 K/0.01–0.05 s{sup −1} based on processing map and microstructure evolution. Typical material instabilities are thought to be attributed to void formation, adiabatic shear bands (ASB), particle debonding, and matrix cracking. Finally, the effect of the plastic deformation zones (PDZs) on the microstructure evolution in this 30 wt.% B{sub 4}C/Al6061 composite is found to be very important. - Highlights: •The hot deformation behavior of the 30 wt.% B{sub 4}C/Al6061 NACs was first analyzed. •The 3D efficiency map and the instability map are developed. •The optimum hot working conditions were identified and validated by SEM and TEM. •The hot deformation schematic diagram of 30 wt.% B{sub 4}C/Al6061 NACs is developed.« less

Formation and hydrolysis of amide bonds by lipase A from Candida antarctica; exceptional features.

PubMed

Liljeblad, Arto; Kallio, Pauli; Vainio, Marita; Niemi, Jarmo; Kanerva, Liisa T

2010-02-21

Various commercial lyophilized and immobilized preparations of lipase A from Candida antarctica (CAL-A) were studied for their ability to catalyze the hydrolysis of amide bonds in N-acylated alpha-amino acids, 3-butanamidobutanoic acid (beta-amino acid) and its ethyl ester. The activity toward amide bonds is highly untypical of lipases, despite the close mechanistic analogy to amidases which normally catalyze the corresponding reactions. Most CAL-A preparations cleaved amide bonds of various substrates with high enantioselectivity, although high variations in substrate selectivity and catalytic rates were detected. The possible role of contaminant protein species on the hydrolytic activity toward these bonds was studied by fractionation and analysis of the commercial lyophilized preparation of CAL-A (Cat#ICR-112, Codexis). In addition to minor impurities, two equally abundant proteins were detected, migrating on SDS-PAGE a few kDa apart around the calculated size of CAL-A. Based on peptide fragment analysis and sequence comparison both bands shared substantial sequence coverage with CAL-A. However, peptides at the C-terminal end constituting a motile domain described as an active-site flap were not identified in the smaller fragment. Separated gel filtration fractions of the two forms of CAL-A both catalyzed the amide bond hydrolysis of ethyl 3-butanamidobutanoate as well as the N-acylation of methyl pipecolinate. Hydrolytic activity towards N-acetylmethionine was, however, solely confined to the fractions containing the truncated form of CAL-A. These fractions were also found to contain a trace enzyme impurity identified in sequence analysis as a serine carboxypeptidase. The possible role of catalytic impurities versus the function of CAL-A in amide bond hydrolysis is further discussed in the paper.

Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.

PubMed

Amacher, Jeanine F; Cushing, Patrick R; Bahl, Christopher D; Beck, Tobias; Madden, Dean R

2013-02-15

PDZ (PSD-95/Dlg/ZO-1) binding domains often serve as cellular traffic engineers, controlling the localization and activity of a wide variety of binding partners. As a result, they play important roles in both physiological and pathological processes. However, PDZ binding specificities overlap, allowing multiple PDZ proteins to mediate distinct effects on shared binding partners. For example, several PDZ domains bind the cystic fibrosis (CF) transmembrane conductance regulator (CFTR), an epithelial ion channel mutated in CF. Among these binding partners, the CFTR-associated ligand (CAL) facilitates post-maturational degradation of the channel and is thus a potential therapeutic target. Using iterative optimization, we previously developed a selective CAL inhibitor peptide (iCAL36). Here, we investigate the stereochemical basis of iCAL36 specificity. The crystal structure of iCAL36 in complex with the CAL PDZ domain reveals stereochemical interactions distributed along the peptide-binding cleft, despite the apparent degeneracy of the CAL binding motif. A critical selectivity determinant that distinguishes CAL from other CFTR-binding PDZ domains is the accommodation of an isoleucine residue at the C-terminal position (P(0)), a characteristic shared with the Tax-interacting protein-1. Comparison of the structures of these two PDZ domains in complex with ligands containing P(0) Leu or Ile residues reveals two distinct modes of accommodation for β-branched C-terminal side chains. Access to each mode is controlled by distinct residues in the carboxylate-binding loop. These studies provide new insights into the primary sequence determinants of binding motifs, which in turn control the scope and evolution of PDZ interactomes.

Assistive Technology: What Physical Educators Need to Know

ERIC Educational Resources Information Center

Laughlin, Michael K.; Murata, Nathan M.; Gonnelli, Michele; Larranaga, John

2018-01-01

Assistive technology supplements and supports the learning of students with disabilities in school and at home. Thanks to federal mandates, students with disabilities receive consideration for assistive technology devices and services--the tools and supports needed to achieve determined learning outcomes. Assistive technology devices and services…

Comparative Study of Protein Immobilization Properties on Calixarene Monolayers

PubMed Central

Chen, Hongxia; Lee, Minsu; Choi, Sungwook; Kim, Jae-Ho; Choi, Heung-Jin; Kim, Sung-Hoon; Lee, Jeabeom; Koh, Kwangnak

2007-01-01

Three calix[4]arene (Cal-4) derivatives of which contain ethylester (1), carboxylic acid (2), and crownether (3) at the lower rim with a common reactive thiol at the upper rim were synthesized and constructed to self-assembled monolayers (SAMs) on Au films. After spectroscopic characterization of monolayers, the interaction between Cal-4 and surface confined bovine serum albumin (BSA) in the SAMs was analyzed by surface plasmon resonance (SPR). The estimated surface concentration of BSA on the Cal-4 SAM with crownether group was the highest among the three Cal-4 derivatives. Anti-hIgG and hIgG pair was employed for the investigation of protein-protein interaction. Molecular interaction between anti-hIgG and hIgG can be detected in a concentration range of 10 pg/mL to 200 pg/mL on the Cal-4 derivative 3 SAM modified SPR chip.

Effects of Computer-Assisted STAD, LTM and ICI Cooperative Learning Strategies on Nigerian Secondary School Students' Achievement, Gender and Motivation in Physics

ERIC Educational Resources Information Center

Gambrari, Isiaka Amosa; Yusuf, Mudasiru Olalere; Thomas, David Akpa

2015-01-01

This study examined the effectiveness of computer-assisted instruction on Student Team Achievement Division (STAD) and Learning Together Model (LTM) cooperative learning strategies on Nigerian secondary students' achievement and motivation in physics. The efficacy of Authors developed computer assisted instructional package (CAI) for teaching…

American River College Beacon Project: Student Catalyst Program - Peer Assisted Learning. First Semester Summary Report.

ERIC Educational Resources Information Center

American River Coll., Sacramento, CA.

The Peer Assisted Learning (PAL) Project at American River College (ARC) in Sacramento, California, was developed to improve retention rates among underrepresented students in math and science classes with high dropout rates. The project involved a group of 24 paid student Learning Assistants (LA's) who successfully completed the targeted courses…

Decisions on Implementing Service-Learning: Perceptions of Physical Therapist Assistant Faculty within a State Technical College System

ERIC Educational Resources Information Center

Herlitzke, Mary Ann

2012-01-01

The Commission on Accreditation of Physical Therapy Education (CAPTE) requires that graduates of physical therapist assistant programs demonstrate a commitment to social responsibility. Service-learning, a method of instruction in which students apply knowledge and skills learned in the classroom to a community need, can assist in the development…

Development of an Interactive Computer-Based Learning Strategy to Assist in Teaching Water Quality Modelling

ERIC Educational Resources Information Center

Zigic, Sasha; Lemckert, Charles J.

2007-01-01

The following paper presents a computer-based learning strategy to assist in introducing and teaching water quality modelling to undergraduate civil engineering students. As part of the learning strategy, an interactive computer-based instructional (CBI) aid was specifically developed to assist students to set up, run and analyse the output from a…

Perceptions from Graduates of Professional Athletic Training Programs Involved in Peer-Assisted Learning

ERIC Educational Resources Information Center

Bates, Dana Karlene

2014-01-01

Context: Research has not explored how peer-assisted learning (PAL) impacts graduates once they are practicing as athletic trainers. Peer-assisted learning has been used in a variety of health education settings but there is a lack of data on its effects on the performance of graduates. Objective: To investigate professional graduates'…

Changing the Marks-Based Culture of Learning through Peer-Assisted Tutorials

ERIC Educational Resources Information Center

Alpay, E.; Cutler, P. S.; Eisenbach, S.; Field, A. J.

2010-01-01

We describe and evaluate an approach to student learning that aims to instil a culture of formative assessment based on peer-assisted learning. The idea is for suitably qualified undergraduates to assist in the running of weekly first-year tutorials. They mark submitted work, provide written and verbal feedback and lead problem-solving discussions…

Pre-Service Teachers' Uses of and Barriers from Adopting Computer-Assisted Language Learning (CALL) Programs

ERIC Educational Resources Information Center

Samani, Ebrahim; Baki, Roselan; Razali, Abu Bakar

2014-01-01

Success in implementation of computer-assisted language learning (CALL) programs depends on the teachers' understanding of the roles of CALL programs in education. Consequently, it is also important to understand the barriers teachers face in the use of computer-assisted language learning (CALL) programs. The current study was conducted on 14…

Effects of a Computer-Assisted Concept Mapping Learning Strategy on EFL College Students' English Reading Comprehension

ERIC Educational Resources Information Center

Liu, Pei-Lin; Chen, Chiu-Jung; Chang, Yu-Ju

2010-01-01

The purpose of this research was to investigate the effects of a computer-assisted concept mapping learning strategy on EFL college learners' English reading comprehension. The research questions were: (1) what was the influence of the computer-assisted concept mapping learning strategy on different learners' English reading comprehension? (2) did…

Effects of Computer-Assisted STAD, LTM and ICI Cooperative Learning Strategies on Nigerian Secondary School Students' Achievement, Gender and Motivation in Physics

ERIC Educational Resources Information Center

Gambari, Amosa Isiaka; Yusuf, Mudasiru Olalere; Thomas, David Akpa

2015-01-01

This study examined the effectiveness of computer-assisted instruction on Student Team Achievement Division (STAD) and Learning Together (LT) cooperative learning strategies on Nigerian secondary students' achievement and motivation in physics. The effectiveness of computer assisted instructional package (CAI) for teaching physics concepts in…

Errors and Intelligence in Computer-Assisted Language Learning: Parsers and Pedagogues. Routledge Studies in Computer Assisted Language Learning

ERIC Educational Resources Information Center

Heift, Trude; Schulze, Mathias

2012-01-01

This book provides the first comprehensive overview of theoretical issues, historical developments and current trends in ICALL (Intelligent Computer-Assisted Language Learning). It assumes a basic familiarity with Second Language Acquisition (SLA) theory and teaching, CALL and linguistics. It is of interest to upper undergraduate and/or graduate…

Mathematics Literacy on Problem Based Learning with Indonesian Realistic Mathematics Education Approach Assisted E-Learning Edmodo

NASA Astrophysics Data System (ADS)

Wardono; Waluya, S. B.; Mariani, Scolastika; Candra D, S.

2016-02-01

This study aims to find out that there are differences in mathematical literacy ability in content Change and Relationship class VII Junior High School 19, Semarang by Problem Based Learning (PBL) model with an Indonesian Realistic Mathematics Education (called Pendidikan Matematika Realistik Indonesia or PMRI in Indonesia) approach assisted Elearning Edmodo, PBL with a PMRI approach, and expository; to know whether the group of students with learning PBL models with PMRI approach and assisted E-learning Edmodo can improve mathematics literacy; to know that the quality of learning PBL models with a PMRI approach assisted E-learning Edmodo has a good category; to describe the difficulties of students in working the problems of mathematical literacy ability oriented PISA. This research is a mixed methods study. The population was seventh grade students of Junior High School 19, Semarang Indonesia. Sample selection is done by random sampling so that the selected experimental class 1, class 2 and the control experiment. Data collected by the methods of documentation, tests and interviews. From the results of this study showed average mathematics literacy ability of students in the group PBL models with a PMRI approach assisted E-learning Edmodo better than average mathematics literacy ability of students in the group PBL models with a PMRI approach and better than average mathematics literacy ability of students in the expository models; Mathematics literacy ability in the class using the PBL model with a PMRI approach assisted E-learning Edmodo have increased and the improvement of mathematics literacy ability is higher than the improvement of mathematics literacy ability of class that uses the model of PBL learning with PMRI approach and is higher than the improvement of mathematics literacy ability of class that uses the expository models; The quality of learning using PBL models with a PMRI approach assisted E-learning Edmodo have very good category.

Data Management Standards in Computer-aided Acquisition and Logistic Support (CALS)

NASA Technical Reports Server (NTRS)

Jefferson, David K.

1990-01-01

Viewgraphs and discussion on data management standards in computer-aided acquisition and logistic support (CALS) are presented. CALS is intended to reduce cost, increase quality, and improve timeliness of weapon system acquisition and support by greatly improving the flow of technical information. The phase 2 standards, industrial environment, are discussed. The information resource dictionary system (IRDS) is described.

Cal OES Internet Home Cal OES Home

Science.gov Websites

Sign In You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Turn on more accessible mode Turn off more accessible mode Skip Ribbon Commands Skip to main content Turn off Animations Turn on Animations image of CA.gov logo image of Cal OES

Soil Moisture Active Passive (SMAP) Calibration and Validation Plan and Current Activities

NASA Technical Reports Server (NTRS)

Jackson, T. J.; Cosh, M.; Bindlish, R.; Crow, W.; Colliander, A.; Njoku, E.; McDonald, K.; Kimball, J.; Belair, S.; Walker, J.;

Resistance of human plasmacytoid dendritic CAL-1 cells to infection with lymphocytic choriomeningitis virus (LCMV) is caused by restricted virus cell entry, which is overcome by contact of CAL-1 cells with LCMV-infected cells.

PubMed

Iwasaki, Masaharu; Sharma, Siddhartha M; Marro, Brett S; de la Torre, Juan C

2017-11-01

Plasmacytoid dendritic cells (pDCs), a main source of type I interferon in response to viral infection, are an early cell target during lymphocytic choriomeningitis virus (LCMV) infection, which has been associated with the LCMV's ability to establish chronic infections. Human blood-derived pDCs have been reported to be refractory to ex vivo LCMV infection. In the present study we show that human pDC CAL-1 cells are refractory to infection with cell-free LCMV, but highly susceptible to infection with recombinant LCMVs carrying the surface glycoprotein of VSV, indicating that LCMV infection of CAL-1 cells is restricted at the cell entry step. Co-culture of uninfected CAL-1 cells with LCMV-infected HEK293 cells enabled LCMV to infect CAL-1 cells. This cell-to-cell spread required direct cell-cell contact and did not involve exosome pathway. Our findings indicate the presence of a novel entry pathway utilized by LCMV to infect pDC. Copyright © 2017. Published by Elsevier Inc.

Clinical and radiographic comparison of indirect pulp treatment using light-cured calcium silicate and mineral trioxide aggregate in primary molars: A randomized clinical trial.

PubMed

Menon, Navya P; Varma, Balagopal R; Janardhanan, Sureshkumar; Kumaran, Parvathy; Xavier, Arun Mamachan; Govinda, Bhat Sangeetha

2016-01-01

To clinically and radiographically evaluate the reparative dentin formation in indirect pulp treatment (IPT) using mineral trioxide aggregate (MTA) and light cured calcium silicate (TheraCal) in primary molars over a period of 6 months. A clinical trial on IPT on 43 primary molars in 21 patients between the age of 4-7 years, divided into two groups: 22 teeth in MTA group and 21 in TheraCal group. Measurement of the variation in dentin thickness was done on the digitalized radiograph at baseline, 3 months and 6 months using CorelDRAW X3 software. Statistical analysis using an independent t -test for intragroup and intergroup comparison showed a significant increase in dentin thickness in both the MTA and TheraCal group (intragroup comparison [ P < 0.05]). However, intergroup comparison between MTA and TheraCal showed no statistical difference in reparative dentin formation ( P > 0.05). Clinically and radiographically, both MTA and TheraCal are good IPT materials. The better handling characteristics and comparable reparative dentin-forming ability of TheraCal make this material an alternative to MTA in pediatric restorative procedures.

Development and evaluation of an audiology app for iPhone/iPad mobile devices.

PubMed

Larrosa, Francisco; Rama-Lopez, Julio; Benitez, Jesus; Morales, Jose M; Martinez, Asuncion; Alañon, Miguel A; Arancibia-Tagle, Diego; Batuecas-Caletrio, Angel; Martinez-Lopez, Marta; Perez-Fernandez, Nicolas; Gimeno, Carlos; Ispizua, Angel; Urrutikoetxea, Alberto; Rey-Martinez, Jorge

2015-01-01

The application described in this study appears to be accurate and valid, thus allowing calculation of a hearing handicap and assessment of the pure-tone air conduction threshold with iPhone/iPad devices. To develop and evaluate a newly developed professional, computer-based hearing handicap calculator and a manual hearing sensitivity assessment test for the iPhone and iPad (AudCal). Multi-center prospective non-randomized validation study. One hundred and ten consecutive adult participants underwent two hearing evaluations, a standard audiometry and a pure-tone air conduction test using AudCal with an iOS device. The hearing handicap calculation accuracy was evaluated comparing AudCal vs a web-based calculator. Hearing loss was found in 83 and 84 out of 220 standard audiometries and AudCal hearing tests (Cohen's Kappa = 0.89). The mean difference between AudCal and standard audiogram thresholds was -0.21 ± 6.38 dB HL. Excellent reliability and concordance between standard audiometry and the application's hearing loss assessment test were obtained (Cronbach's alpha = 0.96; intra-class correlation coefficient = 0.93). AudCal vs a web-based calculator were perfectly correlated (Pearson's r = 1).

Comparing Vegetation Response in Southern, Central and Northern California during the 1997-1998 and 2015-2016 El Niño

NASA Astrophysics Data System (ADS)

Schneiderman, A. C.; Miller, D. L.; Roberts, D. A.

2016-12-01

Quantifying changes in regional impacts of the positive phase of the El Niño Southern Oscillation (ENSO) is very important in order to understand and anticipate the potential impacts of El Niños. Two specific El Niños were chosen for this study because of their similar magnitude and their anomalous differences in local precipitation across California. Using images obtained in southern (SoCal), central (CeCal) and northern California (NoCal) by the Landsat Thematic Mapper (TM) and Operational Land Imager (OLI), we evaluated the geographic patterns of precipitation enhancement during the 1997-1998 and 2015-2016 El Niños. California's vegetation response during the El Niños was measured using Constrained Reference Endmember Selection (CRES) and Spectral Mixture Analysis to select endmembers and map fractional cover for green vegetation (GV), non-photosynthetic vegetation (NPV) and soil. Our initial analysis showed a greater amount of GV in locations where the enhanced precipitation fell (e.g. SoCal in'97-'98 and NoCal in '15-'16). By comparing the '97-'98 and '15-'16 seasonal change in GV (dGV), we anticipated southern California to show a decrease in dGV between the two El Niño's and for NoCal to show an increase in dGV, with CeCal lying between these trends. Our results confirmed this pattern, and in SoCal during the '15-'16 El Niño the total seasonal dGV was +1450.6 km², which showed a negative trend compared to the +3841.2 km² dGV that occurred during the '97-'98 El Niño. We found similar trends in CeCal and NoCal because the dGV in '15-'16 was greater than dGV in '97-'98 for both locations. The lack of precipitation is speculated to be a result of sea surface temperature anomalies (SSTAs), which nearly reached the Tropic of Cancer during the '15-'16 El Niño. If the SSTAs continue to reach very high latitudes during future strong positive ENSO phases, we can speculate that similar trends in GV will be found.

Human-robot cooperative movement training: learning a novel sensory motor transformation during walking with robotic assistance-as-needed.

PubMed

Emken, Jeremy L; Benitez, Raul; Reinkensmeyer, David J

2007-03-28

A prevailing paradigm of physical rehabilitation following neurologic injury is to "assist-as-needed" in completing desired movements. Several research groups are attempting to automate this principle with robotic movement training devices and patient cooperative algorithms that encourage voluntary participation. These attempts are currently not based on computational models of motor learning. Here we assume that motor recovery from a neurologic injury can be modelled as a process of learning a novel sensory motor transformation, which allows us to study a simplified experimental protocol amenable to mathematical description. Specifically, we use a robotic force field paradigm to impose a virtual impairment on the left leg of unimpaired subjects walking on a treadmill. We then derive an "assist-as-needed" robotic training algorithm to help subjects overcome the virtual impairment and walk normally. The problem is posed as an optimization of performance error and robotic assistance. The optimal robotic movement trainer becomes an error-based controller with a forgetting factor that bounds kinematic errors while systematically reducing its assistance when those errors are small. As humans have a natural range of movement variability, we introduce an error weighting function that causes the robotic trainer to disregard this variability. We experimentally validated the controller with ten unimpaired subjects by demonstrating how it helped the subjects learn the novel sensory motor transformation necessary to counteract the virtual impairment, while also preventing them from experiencing large kinematic errors. The addition of the error weighting function allowed the robot assistance to fade to zero even though the subjects' movements were variable. We also show that in order to assist-as-needed, the robot must relax its assistance at a rate faster than that of the learning human. The assist-as-needed algorithm proposed here can limit error during the learning of a dynamic motor task. The algorithm encourages learning by decreasing its assistance as a function of the ongoing progression of movement error. This type of algorithm is well suited for helping people learn dynamic tasks for which large kinematic errors are dangerous or discouraging, and thus may prove useful for robot-assisted movement training of walking or reaching following neurologic injury.

Learning Styles and Individual Differences in Learning English Idioms via Computer Assisted Language Learning in English as a Second Language.

ERIC Educational Resources Information Center

Viteli, Jarmo

The purpose of this study was to determine the learning styles of English-as-a-Second-Language (ESL) students and individual differences in learning English idioms via computer assisted language learning (CALL). Thirty-six Hispanic students, 26 Japanese students, and 6 students with various language backgrounds from the Nova University Intensive…

Mobile-Assisted Second Language Learning: Developing a Learner-Centered Framework

ERIC Educational Resources Information Center

Leow, Choy Khim; Yahaya, Wan Ahmad Jaafar Wan; Samsudin, Zarina

2014-01-01

The Mobile Assisted Language Learning concept has offered infinite language learning opportunities since its inception 20 years ago. Second Language Acquisition however embraces a considerably different body of knowledge from first language learning. While technological advances have optimized the psycholinguistic environment for language…

Medical Assisting. A Learning Guide.

ERIC Educational Resources Information Center

Meyer, Rosemarie

This competency-based, individualized learning package, consisting of 50 learning guides, is designed for use by students who are studying to become medical assistants. Included among the topics addressed in the individual learning guides are the following: using and caring for microscopes, understanding medical ethics and law, developing…

Decadally resolved Lateglacial radiocarbon evidence from New Zealand kauri

NASA Astrophysics Data System (ADS)

Hogg, Alan; Southon, John; Turney, Chris; Palmer, Jonathan; Bronk Ramsey, Christopher; Fenwick, Pavla; Boswijk, Gretel; Büntgen, Ulf; Friedrich, Michael; Helle, Gerhard; Hughen, Konrad; Jones, Richard; Kromer, Bernd; Noronha, Alexandra; Reinig, Frederick; Reynard, Linda; Staff, Richard; Wacker, Lukas

2017-04-01

The Last Glacial-Interglacial Transition (LGIT; 15,000 - 11,000 cal BP) was characterised by complex spatiotemporal patterns of climate change, with numerous studies requiring accurate chronological control to decipher leads from lags in global palaeoclimatic, -environmental and archaeological records. However, close scrutiny of the few available tree-ring chronologies and radiocarbon-dated sequences composing the IntCal13 radiocarbon (14C) calibration curve, indicates significant weakness in 14C calibration across key periods of the LGIT. Here, we present a decadally-resolved atmospheric 14C record derived from New Zealand kauri spanning Greenland Stadial 1 (GS-1; 12,900 - 11,650 cal BP). Two floating kauri 14C time series, curve-matched to IntCal13, serve as a radiocarbon backbone through GS-1. Floating Northern Hemisphere (NH) 14C datasets are matched against the new kauri data, forming a robust NH 14C time series to 14,200 cal BP. Our results show that IntCal13 is questionable from 12,200 - 11,900 cal BP and the 10,400 BP 14C plateau is approximately five decades too short. By precisely aligning Southern and Northern Hemisphere tree-ring 14C records with marine 14C sequences, we document two relatively short periods of North Atlantic Meridional Overturning Circulation (AMOC) collapse during GS-1. Hence, sustained North Atlantic cooling across GS-1 was not driven by a prolonged AMOC reduction but was probably due to an equatorward migration of the Polar Front.

Late Quaternary deglacial history of the Mérida Andes, Venezuela

NASA Astrophysics Data System (ADS)

Stansell, Nathan D.; Abbott, Mark B.; Polissar, Pratigya J.; Wolfe, Alexander P.; Bezada, Maximiliano; Rull, Valentí

2005-10-01

Radiocarbon-dated sediment cores from seven lakes and two bogs spanning the Cordillera de Mérida in the Venezuelan Andes were used to identify and date the regional history of late Pleistocene and Holocene glacial activity. Coring sites were selected at different elevations across a pronounced rain shadow from southeast (wet) to northwest (dry). Sediment lithostratigraphy and magnetic susceptibility, in conjunction with AMS radiocarbon dates on macrofossils and charcoal, were used to constrain deglaciation. The local expression of the Last Glacial Maximum occurred between 22 750 and 19 960 cal. yr BP. On the wetter southeastern side of the Cordillera de Mérida, glaciers had significantly retreated by 15 700 cal. yr BP, followed by several minor glacial advances and retreats between 14 850 and 13 830 cal. yr BP. At least one major glacial readvance occurred between 13 830 and 10 000 cal. yrBP in the wetter southeastern sector of the region. The drier northwest side of the Cordillera de Mérida records initial glacial retreat by 14240cal.yrBP. Multiple sites on both sides of the Mérida Andes record a further phase of extensive deglaciation approximately 10000cal.yrBP. However, the north-northwest facing Mucubají catchment remained partially glaciated until ca. 6000cal.yrBP. Deglacial ages from the Venezuelan Andes are consistently younger than those reported from the Southern Hemisphere Andes, suggesting an inter-hemispheric deglacial lag in the northern tropics of the order of two thousand years.

Improve efficacy of topical ALA-PDT by calcipotriol through up-regulation of coproporphyrinogen oxidase.

PubMed

Yang, Deng-Fu; Chen, Jia-Haur; Chiang, Chun-Pin; Huang, Zheng; Lee, Jeng-Woei; Liu, Chung-Ji; Chang, Junn-Liang; Hsu, Yih-Chih

2014-09-01

Topical 5-aminolevulinic acid-mediated photodynamic therapy (topical ALA-PDT) is effective for treating oral precancerous lesions. The aim of this in vivo and in vitro study was to examine whether the efficacy of topical ALA-PDT could be further improved by calcipotriol (CAL). Precancerous lesions in the buccal pouch of hamsters were induced by dimethylbenz(a)anthracene (DMBA). Lesions were treated with multiple topical ALA-PDT with or without CAL pretreatment. ALA-induced protoporphyrine IX (PpIX) was monitored by in situ fluorescence measurement. The effect of CAL on heme-related enzymes (CPOX, PPOX, and FECH) were examined in an in vitro model using human squamous cell carcinoma (SCC) cells (SCC4, SAS) using Western blots. Fluorescence spectroscopy revealed that PpIX reached its peak level in precancerous epithelial cells of buccal pouch at 2.5 or 3.5h without or with CAL pretreatment, respectively. Both treatment regimens showed similar response rates, but the complete response was achieved after 5 times of ALA-PDT and 3 times of CAL-ALA-PDT (p<0.001). Pretreatment of SCC cells with 10(-8) or 10(-7)M CAL could result in a significant cell death (p<0.05) and an elevation of CPOX protein level. Topical CAL can improve the efficacy of ALA-PDT in treating precancerous lesions, likely through the increase in CPOX level and in PpIX production. Copyright © 2014 Elsevier B.V. All rights reserved.

Quartz grains reveal sedimentary palaeoenvironment and past storm events: A case study from eastern Baltic

NASA Astrophysics Data System (ADS)

Kalińska-Nartiša, Edyta; Stivrins, Normunds; Grudzinska, Ieva

2018-01-01

Sediment record collected from the coastal lake serves as a powerful tool for reconstructing changes in palaeoenvironment and understanding the potential signals of past storminess. In this study, we use several proxies from sediment of the Holocene Thermal Maximum at coastal Lake Lilaste, Latvia. We focus on surface texture of quartz grains from the mineral inorganic fraction as indicators of depositional environments. We then use this as a proxy for potential storm transport and combine with information on granulometry, diatom stratigraphy and chronology to answer the question whether flux of quartz grains in the lake originated from the sea or from the land. Analyses in a binocular and scanning electron microscope reveal that most of the investigated quartz grains originate from dwelling in the seawater and wave action in the nearshore zone. Grains representing very energetic subaqueous environment similar to storm events are also present. Terrestrial record is of minor significance and visible through occurrence of aeolian quartz grains. During drier and colder conditions, an influx of sand with aeolian imprint was delivered to the lake between 8500 and 7800 cal yr BP. Marine and terrestrial conditions alternated between 7800 and 6000 cal yr BP. Storm-induced grains were likely deposited three times: at 7300 cal yr BP, 6600-6400 cal yr BP, and 6200-6000 cal yr BP. Overall stable marine environmental conditions prevailed between 6000 and 4000 cal yr BP except of the last portion of terrestrial-induced sediment at 4100 cal yr BP.

Were they all giants? Perspectives on late Holocene plate-boundary earthquakes at the northern end of the Cascadia subduction zone

NASA Astrophysics Data System (ADS)

Hutchinson, Ian; Clague, John

2017-08-01

The relative magnitude of plate-boundary earthquakes at the northern end of the Cascadia subduction zone was assessed from the temporal concordance between the ages of coseismically buried late Holocene soils in southwest Washington, their counterparts in central and southern Cascadia, offshore turbidites, and paleoseismic deposits on the west coast of Vancouver Island. Only three of the seven buried soils in southwest Washington that can be reliably traced as buried soils or paleotsunami deposits in the coastal lowlands of south-central and southern Cascadia have well-dated counterparts in northern Cascadia. The three wide-ranging events date from Cascadia earthquakes Y (∼250 cal BP), U (∼1260 cal BP), and N (∼2520 cal BP). All three likely ruptured the entire plate margin, and therefore potentially qualify as ;giants; (Mw ≥ 9). Deposits that may derive from tsunamis generated by earthquakes S (∼1570 cal BP), L (∼2870 cal BP) and J (∼3360 cal BP) can also be found in northern Cascadia, but the ages of these deposits are not yet well-enough constrained to determine whether they are coeval with their southern counterparts. Earthquake W (∼850 cal BP), appears to be present in the northern Cascadia paleoseismic record, but yields considerably older ages than in central Cascadia, and may be missing from southernmost Cascadia. The onshore record of an offshore turbidite (T2) displays a similar spatio-temporal pattern to that of earthquake W.

American River College Beacon Project Student Catalyst Program: Peer Assisted Learning. Annual Report, 1992-93.

ERIC Educational Resources Information Center

Reitz, Nancy; McCuen, Sharon

American River College's (California) Peer Assisted Learning (PAL) project is a 2-year project initiated in 1992 to improve the retention and performance of minority students and others in math, biology, and chemistry through increased contact and involvement with their peers. PAL involves a cadre of 24 student Learning Assistants (LA's) who have…

The Impact of Utilising Mobile Assisted Language Learning (MALL) on Vocabulary Acquisition among Migrant Women English Learners

ERIC Educational Resources Information Center

Ahmad, Kham Sila; Armarego, Jocelyn; Sudweeks, Fay

2017-01-01

Aim/Purpose: To develop a framework for utilizing Mobile Assisted Language Learning (MALL) to assist non-native English migrant women to acquire English vocabulary in a non-formal learning setting. Background: The women in this study migrated to Australia with varied backgrounds including voluntary or forced migration, very low to high levels of…

A review of peer-assisted learning to deliver interprofessional supplementary image interpretation skills.

PubMed

Bain, P; Wareing, A; Henderson, I

2017-09-01

Peer-assisted learning provides a means through which individuals can learn from one another through a reciprocal process. Radiographic image interpretation skills are fundamental to both diagnostic radiography students and medical students due to their shared role in preliminary evaluation of conventional radiographic images. Medical students on graduation, may not be well prepared to carry out image interpretation, since evidence suggests that they perform less well than radiographers in e.g. Accident and Emergency situations. A review of literature was conducted exploring the application of peer-assisted learning within diagnostic radiography and health education more widely as well as the practice of initial image interpretation. An extensive and systematic search strategy was developed which provided a range of material related to the areas. An overview was obtained of the effectiveness of peer-assisted learning and the issues associated with development of image interpretation skills and a degree of discrepancy was identified between the two cohorts regarding their interpretative competence and confidence. This inconsistency may create an opportunity to apply peer-assisted learning, better preparing both disciplines for the practical application of image interpretation skills. The review identified the lack of a substantial evidence base relating to peer-assisted learning in radiography. Peer-assisted learning is not widely embraced in an interprofessional context. Multiple positive factors of such an intervention are identified which outweigh perceived negative issues. Student teacher and learner may benefit as should the clinical service from enhanced practitioner performance. The findings justify further research to develop the evidence base. Copyright © 2017 The College of Radiographers. Published by Elsevier Ltd. All rights reserved.

An exploration of peer-assisted learning in undergraduate nursing students in paediatric clinical settings: An ethnographic study.

PubMed

Carey, Matthew C; Chick, Anna; Kent, Bridie; Latour, Jos M

2018-06-01

Peer-assisted leaning relates to the acquisition of knowledge and skills through shared learning of matched equals. The concept has been explored within the field of nurse education across a range of learning environments, but its impact in practice is still relatively unknown. This paper reports on findings when observing paediatric undergraduate nursing students who engage in PAL within the clinical practice setting. The aim of this paper is to report the findings of a study undertaken to explore peer-assisted learning in undergraduate nursing students, studying children's health, in the clinical practice setting. A qualitative ethnographic study using non-participant observations. A range of inpatient paediatric clinical settings across two teaching hospitals. First, second and third year paediatric student nurses enrolled on a Bachelor of Nursing Programme. Non-participant observations were used to observe a range of interactions between the participants when engaging in peer-assisted learning within the same clinical area. A total of 67 h of raw data collected across all observations was analysed using framework analysis to draw together key themes. Of the 20 identified students across two hospitals, 17 agreed to take part in the study. Findings were aggregated into three key themes; 1. Peers as facilitators to develop learning when engaging in peer-assisted learning, 2. Working together to develop clinical practice and deliver care, 3. Positive support and interaction from peers to enhance networking and develop working structure. Peer-assisted learning in undergraduate children's nursing students stimulates students in becoming engaged in their learning experiences in clinical practice and enhance collaborative support within the working environment. The benefits of peer-assisted learning in current clinical practice settings can be challenging. Therefore, education and practice need to be aware of the benefits and their contribution towards future strategies and models of learning. Copyright © 2018 Elsevier Ltd. All rights reserved.

Medical Assisting Learning Guides.

ERIC Educational Resources Information Center

Meyer, Rose

Eight student learning guides are provided for a medical assisting program at the secondary, postsecondary, or adult level. Each learning guide is composed of these component parts: a title page that states the task, purpose, program and task numbers, estimated time, and prerequisites; an optional learning contract that includes terminal…

77 FR 24667 - TANF Assistance and Electronic Benefit Transfer Transactions; Request for Public Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... Family Assistance (OFA) is interested in learning about how States deliver Temporary Assistance to Needy... types of restrictions on assistance usage. OFA also is interested in learning about States' current... as ``the use of a credit or debit card service, automated teller machine, point-of-sale terminal, or...

Enhancing Student Learning of Research Methods through the Use of Undergraduate Teaching Assistants

ERIC Educational Resources Information Center

Crowe, Jessica; Ceresola, Ryan; Silva, Tony

2014-01-01

By using a quasi-experimental design, in this study, we test the effect of undergraduate teaching assistants on student learning. Data were collected from 170 students enrolled in four sections of a quantitative research methods course, two sections without undergraduate teaching assistants and two sections with undergraduate teaching assistants,…

Comparative Proteomics of Tandem Mass Spectrometry Analyses for Bacterial Strains Identification and Differentiation

DTIC Science & Technology

2012-02-01

risk, bio -terrorism utility, Homeland Security, agricultural monitoring, quality of foodstuffs, environmental monitoring, and biological warfare agents...CAL19717 Putative surface antigen CAL21872 Putative sigma 54 modulation protein NP_395233 Plasminogen activator protease precursor CAL19882 OMP...S. (2005). Chemical and biological weapons : current concepts for future defenses. Johns Hopkins APL Tech. Digest, 26, 321-333. Dworzanski, J.P

Late Holocene vegetation and fire dynamics from a savanna-forest ecotone in Roraima state, northern Brazilian Amazon

NASA Astrophysics Data System (ADS)

da Silva Meneses, Maria Ecilene Nunes; da Costa, Marcondes Lima; Behling, Hermann

2013-03-01

Two sediment cores from Mauritia flexuosa palm swamps have been studied by pollen and charcoal analysis. The cores Fazenda Cigana (FC) and Terra Indígena Aningal (TIA) were taken from a savanna-forest ecotone area in the Roraima State, northern Brazilian Amazon. Based on 5 radiocarbon dates, these records allow the reconstruction of the vegetation fire and climate dynamics during the past 1550 years. At the FC site was recorded a higher proportion of forest cover, suggesting local wetter climatic conditions favorable for forest expansion, especially by gallery forests, between 1550 and 1400 cal yr BP. Stands of M. flexuosa started to establish on the site indicating sufficient soil moisture. From 1400 to 1050 cal yr BP, forest cover retreated while savanna, and the Mauritia palm swamp expanded considerably. The FC site was marked by savanna and Mauritia cover with a slight increase of forest between ca. 1050 and 900 cal yr BP. From 900 to 300 cal yr BP the savanna and palm swamp taxa became dominant and the forest area decreased. At the TIA site the savanna cover was dominant between 1200 and 1000 cal yr BP. From 1000 to 700 forest expanded while savanna and Mauritia palm swamp reduced. Between 700 and 300 cal yr BP savanna and Mauritia palm swamp increased and forest area decreased. The high amount of charred particles found in the sediments, indicate fires with a marked increase between 1400 to 1000 cal yr BP (FC site) and 700 to 300 cal yr BP (TIA site), and probably caused the retreat of forest cover during these two time intervals. The relatively lower fire activity after 300 cal yr BP until present-day favored the increase of forested area at both TIA and FC sites. The arrival of the European settler and the subsequent introduction of cattle, is suggested as the main reason for the decrease of fire in the study region. The results point the fire caused by indigenous people as the principal controlling factor for forest and savanna dynamics during the past 1550 years.

Cal-Bridge and CAMPARE: Engaging Underrepresented Students in Physics and Astronomy

NASA Astrophysics Data System (ADS)

Rudolph, Alexander L.; Cal-Bridge and CAMPARE Teams

2018-01-01

We describe two programs, Cal-Bridge and CAMPARE, with the common mission of increasing participation of groups traditionally underrepresented in astronomy, through summer research opportunities, in the case of CAMPARE, scholarships in the case of Cal-Bridge, and significant mentoring in both programs, creating a national impact on their numbers successfully pursuing a PhD in the field.In 8 years, the CAMPARE program has sent 112 students, >80% from underrepresented groups, to conduct summer research at one of 14 major research institutions throughout the country. Of the CAMPARE scholars who have graduated with a Bachelor’s degree, almost two-thirds (65%) have completed or are pursuing graduate education in physics, astronomy, or a related field, at institutions including UCLA, UC Riverside, UC Irvine, UC Santa Barbara, USC, Stanford, Univ. of Arizona, Univ. of Washington, Univ. of Rochester, Michigan State Univ., Georgia Tech, Georgia State Univ., Kent State, Indiana Univ., Univ. of Oregon, Syracuse Univ., Montana State Univ., and the Fisk-Vanderbilt Master’s-to-PhD program.Now entering its fourth year, the Cal-Bridge program is a CSU-UC Bridge program comprised of >140 physics and astronomy faculty from 9 University of California (UC), 15 California State University (CSU), and 30 California Community College (CCC) campuses throughout California. In the first four years, 34 Cal-Bridge Scholars have been selected, including 22 Hispanic, 3 African-American and 13 women students, 10 of whom are from URM groups. Thirty (30) of the 34 Cal-Bridge Scholars are first generation college students. In the last two years, 11 of 13 Cal-Bridge Scholars have begun PhD programs in physics or astronomy at top PhD programs nationally. Three (3) of these 11 scholars have won NSF Graduate Research Fellowships; one more received an Honorable Mention. The next cohort applies this fall.Cal-Bridge provides much deeper mentoring and professional development experiences over the last two years of undergraduate and first year of graduate school to students from this diverse network of higher education institutions. Cal-Bridge Scholars benefit from substantial financial support, intensive, joint mentoring by CSU and UC faculty, professional development workshops, and exposure to research opportunities at the participating UC campuses.

Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam is Effective, Independent of Body Mass Index and the Extent and Severity of Psoriasis.

PubMed

Stein Gold, Linda; Villumsen, John; Rosen, Monika

2016-12-01

Good treatment adherence is important in the effective management of psoriasis and is related to both the frequency of applications and the amount of product used versus the recommended dose. The efficacy and safety of fixed combination calcipotriol 50 µg/g (Cal) and betamethasone 0.5 mg/g as dipropionate (BD) in the treatment of psoriasis is well established; an aerosol foam formulation has been developed to enhance adherence. This subanalysis from the Phase III PSO-FAST study evaluates the amount of Cal/BD foam used during treatment and the association between the extent and severity of baseline disease. Patients (≥18 years) with mild-to-severe body psoriasis were randomized 3:1 to once-daily Cal/BD foam or vehicle. The amount of Cal/BD foam and vehicle used over the 4-week study period was evaluated according to three baseline disease assessments: extent of body surface area (BSA) affected by psoriasis, physician's global assessment of disease severity (PGA) and modified psoriasis area and severity index (mPASI). Treatment success and mPASI75 rates were assessed according to body mass index (BMI) and body weight. 323 patients were randomized to Cal/BD foam and 103 to vehicle. At week 4, the mean total amount of Cal/BD foam used was 120.8 g (n = 293), which was similar to the amount of vehicle used (128.9 g; n = 98). The total amount of Cal/BD foam used at week 4 was greater with increasing BSA and increasing severity of baseline PGA and mPASI. Throughout the study, 93.1% of patients in the Cal/BD foam group and 99.0% of patients in the vehicle group missed ≤10% of treatment applications. Treatment success and mPASI75 rates were generally similar when stratified according to BMI and body weight. This subanalysis demonstrates that Cal/BD aerosol foam is used appropriately and is effective for the treatment of psoriasis, independent of BMI and the extent or severity of disease. NCT01866163. LEO Pharma A/S.

Holocene environmental and climatic changes at Gorgo Basso, a coastal lake in southern Sicily, Italy

NASA Astrophysics Data System (ADS)

Tinner, Willy; van Leeuwen, Jacqueline F. N.; Colombaroli, Daniele; Vescovi, Elisa; van der Knaap, W. O.; Henne, Paul D.; Pasta, Salvatore; D'Angelo, Stefania; La Mantia, Tommaso

2009-07-01

We used a new sedimentary record to reconstruct the Holocene vegetation and fire history of Gorgo Basso, a coastal lake in south-western Sicily (Italy). Pollen and charcoal data suggest a fire-prone open grassland near the site until ca 10,000 cal yr BP (8050 cal BC), when Pistacia shrubland expanded and fire activity declined, probably in response to increased moisture availability. Evergreen Olea europaea woods expanded ca 8400 to decline abruptly at 8200 cal yr BP, when climatic conditions became drier at other sites in the Mediterranean region. Around 7000 cal yr BP evergreen broadleaved forests ( Quercus ilex, Quercus suber and O. europaea) expanded at the cost of open communities. The expansion of evergreen broadleaved forests was associated with a decline of fire and of local Neolithic ( Ficus carica-Cerealia based) agriculture that had initiated ca 500 years earlier. Vegetational, fire and land-use changes ca 7000 cal yr BP were probably caused by increased precipitation that resulted from (insolation-forced) weakening of the monsoon and Hadley circulation ca 8000-6000 cal yr BP. Low fire activity and dense coastal evergreen forests persisted until renewed human activity (probably Greek, respectively Roman colonists) disrupted the forest ca 2700 cal yr BP (750 BC) and 2100 cal yr BP (150 BC) to gain open land for agriculture. The intense use of fire for this purpose induced the expansion of open maquis, garrigue, and grassland-prairie environments (with an increasing abundance of the native palm Chamaerops humilis). Prehistoric land-use phases after the Bronze Age seem synchronous with those at other sites in southern and central Europe, possibly as a result of climatic forcing. Considering the response of vegetation to Holocene climatic variability as well as human impact we conclude that under (semi-)natural conditions evergreen broadleaved Q. ilex- O. europaea (s.l.) forests would still dominate near Gorgo Basso. However, forecasted climate change and aridification may lead to a situation similar to that before 7000 cal yr BP and thus trigger a rapid collapse of the few relict evergreen broadleaved woodlands in coastal Sicily and elsewhere in the southern Mediterranean region.

Older adults challenged financially when adult children move home.

PubMed

Wallace, Steven P; Padilla-Frausto, D Imelda

2014-02-01

This policy brief looks at the financial burdens imposed on older Californians when adult children return home, often due to a crisis not of their own making, to live with their parents. The findings show that on average in California, the amount of money that older adults need in order to maintain a minimally decent standard of living while supporting one adult child in their home increases their expenses by a minimum of 50 percent. Low-income older adults are usually on fixed incomes, so helping an adult child can provide the child with a critical safety net but at the cost of the parents' own financial well-being. Policy approaches to assisting this vulnerable population of older adults include implementing reforms to increase Supplemental Security Income (SSI), improving the availability of affordable housing, assuring that all eligible nonelderly adults obtain health insurance through health care reform's expansion of Medi-Cal and subsidies, and increasing food assistance through SNAP and senior meal programs.

Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil.

PubMed

Tian, Yuting; Xu, Zhenbo; Zheng, Baodong; Martin Lo, Y

2013-01-01

The effectiveness of ultrasonic-assisted extraction (UAE) of pomegranate seed oil (PSO) was evaluated using a variety of solvents. Petroleum ether was the most effective for oil extraction, followed by n-hexane, ethyl acetate, diethyl ether, acetone, and isopropanol. Several variables, such as ultrasonic power, extraction temperature, extraction time, and the ratio of solvent volume and seed weight (S/S ratio) were studied for optimization using response surface methodology (RSM). The highest oil yield, 25.11% (w/w), was obtained using petroleum ether under optimal conditions for ultrasonic power, extraction temperature, extraction time, and S/S ratio at 140 W, 40 °C, 36 min, and 10 ml/g, respectively. The PSO yield extracted by UAE was significantly higher than by using Soxhlet extraction (SE; 20.50%) and supercriti cal fluid extraction (SFE; 15.72%). The fatty acid compositions were significantly different among the PSO extracted by Soxhlet extraction, SFE, and UAE, with punicic acid (>65%) being the most dominant using UAE. Copyright © 2012 Elsevier B.V. All rights reserved.

Educating the Educators: Developing Those Who Support Learning for Students with Additional Learning Needs

ERIC Educational Resources Information Center

McLachlan, Benita; Davis, Geraldine

2013-01-01

This article reports findings from a research project which developed and introduced the Enhanced Learning Support Assistant Programme (ELSAP) as a source of professional development for learning support assistants who were supporting students with additional learning needs in a college of further education in England. The purpose of this article…

Mobile-Assisted Language Learning: Student Attitudes to Using Smartphones to Learn English Vocabulary

ERIC Educational Resources Information Center

Davie, Neil; Hilber, Tobias

2015-01-01

This project examines mobile-assisted language learning (MALL) and in particular the attitudes of undergraduate engineering students at the South Westphalia University of Applied Sciences towards the use of the smartphone app Quizlet to learn English vocabulary. Initial data on attitudes to learning languages and to the use of mobile devices to do…

Effectiveness of a Service Learning Model with Allied Health Assistant Students in Aged Care

ERIC Educational Resources Information Center

Zulch, Debbie; Saunders, Rosemary; Peters, Judith; Quinlivan, Julie

2016-01-01

This paper explores the impact of a student learning activity involving service learning. As part of a vocational course in the Academy of Health Sciences at a Western Australian TAFE (Technical and Further Education) institute, Allied Health Assistant (AHA) students participated in a service learning program focused on work-based learning in…

The Temporal and Dynamic Nature of Self-Regulatory Processes during Independent and Externally Assisted Hypermedia Learning

ERIC Educational Resources Information Center

Johnson, Amy M.; Azevedo, Roger; D'Mello, Sidney K.

2011-01-01

This study examined the temporal and dynamic nature of students' self-regulatory processes while learning about the circulatory system with hypermedia. A total of 74 undergraduate students were randomly assigned to 1 of 2 conditions: independent learning or externally assisted learning. Participants in the independent learning condition used a…

Development of a Peer-Assisted Learning Strategy in Computer-Supported Collaborative Learning Environments for Elementary School Students

ERIC Educational Resources Information Center

Tsuei, Mengping

2011-01-01

This study explores the effects of Electronic Peer-Assisted Learning for Kids (EPK), on the quality and development of reading skills, peer interaction and self-concept in elementary students. The EPK methodology uses a well-developed, synchronous computer-supported, collaborative learning system to facilitate students' learning in Chinese. We…

Holocene environmental changes in southern Kamchatka, Far Eastern Russia, inferred from a pollen and testate amoebae peat succession record

NASA Astrophysics Data System (ADS)

Klimaschewski, A.; Barnekow, L.; Bennett, K. D.; Andreev, A. A.; Andrén, E.; Bobrov, A. A.; Hammarlund, D.

2015-11-01

High resolution palaeoenvironmental records in Far-Eastern Russia are rare, and the Kamchatka Peninsula is among the least studied areas of the region. This paper describes a record spanning the last ca. 11,000 yr, obtained from a bog in the southern part of Kamchatka. The radiocarbon dated core was analysed for pollen, testate amoebae, charcoal and loss-on-ignition (LOI). The vegetation during the early Holocene was dominated by grasses (Poaceae), birch (Betula) and heath (Ericaceae p. p.). Around 10,300 cal yr BP there was a substantial change in the vegetation cover to shrub alder (Alnus viridis s.l.) stands with sedges and ferns (Polypodiophyta) as well as herbs such as meadow rue (Thalictrum) in the understory. In the surroundings of Utka peatlands started to form. The variations in the vegetation cover were most probably caused by climatic changes. At the beginning of sediment accumulation, before 10,300 cal yr BP, the composition of the vegetation points to cooler summers and/or decreased annual precipitation. Around 10,300 cal yr BP, changes in vegetation occurred due to rising temperatures and/or changed water regimes. Increased abundancies of dry indicating testate amoebae after 9100 cal yr BP point to intermediate to dry soil conditions. Between 8600 and 7700 cal yr BP tree alder (Alnus incana) was widely spread at the site which probably indicates optimal environmental conditions. The tephra layer at 381-384.5 cm (ca. 8500 cal yr BP) produces a strong impact on the testate amoebae assemblages. At 7700 cal yr BP there was a sudden drop of A. incana in the local vegetation. From this time on, A. incana and also A. viridis decrease continuously whereas Betula gradually increases. The upper part of the sequence (after 6300 cal yr BP) shows higher abundancies of meadowsweet (Filipendula) and sweet gale (Myrica) pollen. After 6300 cal yr BP, changes in testate amoebae demonstrate variable soil moisture conditions at the site. Between 3700 and 1800 cal yr BP, wet conditions dominate as dry indicating testate amoebae decrease. After 1800 cal yr BP soil conditions become more variable again but this time with dry dominating testate amoebae. In contrast to surrounding regions, there is no evidence of trees such as spruce or larch growing in the surroundings of the site even though those trees are characteristic of many eastern Siberian sites. This difference might be because of the maritime influence of the Okhotsk Sea. Even dwarf pine (Pinus pumila), which is currently widely dispersed in northern Kamchatka, became part of the local vegetation only during the last 700 yr.

AB 9: California bill would end county mandate for last-resort care, including communicable diseases.

PubMed

1996-02-16

The California Assembly passed a bill to end the current requirement that counties provide general assistance and medical care as last resort care to persons who do not have access to Medi-Cal or private insurance. There is concern that all counties will close the facilities and reduce or eliminate last resort care, leaving people with no access to treatment when they become ill. The bill is now in the California State Senate. AIDS organizations are urging Californians to call their state senator and urge them to oppose the bill. More information is available by contacting AIDS Project Los Angeles, Life AIDS Lobby (916)444-0424, or ACT UP/Golden Gate.

Pedagogy and Related Criteria: The Selection of Software for Computer Assisted Language Learning

ERIC Educational Resources Information Center

Samuels, Jeffrey D.

2013-01-01

Computer-Assisted Language Learning (CALL) is an established field of academic inquiry with distinct applications for second language teaching and learning. Many CALL professionals direct language labs or language resource centers (LRCs) in which CALL software applications and generic software applications support language learning programs and…

Performance, Cognitive Load, and Behaviour of Technology-Assisted English Listening Learning: From CALL to MALL

ERIC Educational Resources Information Center

Chang, Chi-Cheng; Warden, Clyde A.; Liang, Chaoyun; Chou, Pao-Nan

2018-01-01

This study examines differences in English listening comprehension, cognitive load, and learning behaviour between outdoor ubiquitous learning and indoor computer-assisted learning. An experimental design, employing a pretest-posttest control group is employed. Randomly assigned foreign language university majors joined either the experimental…

Critical Thinking Skills of Students through Mathematics Learning with ASSURE Model Assisted by Software Autograph

NASA Astrophysics Data System (ADS)

Kristianti, Y.; Prabawanto, S.; Suhendra, S.

2017-09-01

This study aims to examine the ability of critical thinking and students who attain learning mathematics with learning model ASSURE assisted Autograph software. The design of this study was experimental group with pre-test and post-test control group. The experimental group obtained a mathematics learning with ASSURE-assisted model Autograph software and the control group acquired the mathematics learning with the conventional model. The data are obtained from the research results through critical thinking skills tests. This research was conducted at junior high school level with research population in one of junior high school student in Subang Regency of Lesson Year 2016/2017 and research sample of class VIII student in one of junior high school in Subang Regency for 2 classes. Analysis of research data is administered quantitatively. Quantitative data analysis was performed on the normalized gain level between the two sample groups using a one-way anova test. The results show that mathematics learning with ASSURE assisted model Autograph software can improve the critical thinking ability of junior high school students. Mathematical learning using ASSURE-assisted model Autograph software is significantly better in improving the critical thinking skills of junior high school students compared with conventional models.

Postglacial viability and colonization in North America’s ice-free corridor

NASA Astrophysics Data System (ADS)

Pedersen, Mikkel W.; Ruter, Anthony; Schweger, Charles; Friebe, Harvey; Staff, Richard A.; Kjeldsen, Kristian K.; Mendoza, Marie L. Z.; Beaudoin, Alwynne B.; Zutter, Cynthia; Larsen, Nicolaj K.; Potter, Ben A.; Nielsen, Rasmus; Rainville, Rebecca A.; Orlando, Ludovic; Meltzer, David J.; Kjær, Kurt H.; Willerslev, Eske

2016-09-01

During the Last Glacial Maximum, continental ice sheets isolated Beringia (northeast Siberia and northwest North America) from unglaciated North America. By around 15 to 14 thousand calibrated radiocarbon years before present (cal. kyr BP), glacial retreat opened an approximately 1,500-km-long corridor between the ice sheets. It remains unclear when plants and animals colonized this corridor and it became biologically viable for human migration. We obtained radiocarbon dates, pollen, macrofossils and metagenomic DNA from lake sediment cores in a bottleneck portion of the corridor. We find evidence of steppe vegetation, bison and mammoth by approximately 12.6 cal. kyr BP, followed by open forest, with evidence of moose and elk at about 11.5 cal. kyr BP, and boreal forest approximately 10 cal. kyr BP. Our findings reveal that the first Americans, whether Clovis or earlier groups in unglaciated North America before 12.6 cal. kyr BP, are unlikely to have travelled by this route into the Americas. However, later groups may have used this north-south passageway.

Postglacial viability and colonization in North America's ice-free corridor.

PubMed

Pedersen, Mikkel W; Ruter, Anthony; Schweger, Charles; Friebe, Harvey; Staff, Richard A; Kjeldsen, Kristian K; Mendoza, Marie L Z; Beaudoin, Alwynne B; Zutter, Cynthia; Larsen, Nicolaj K; Potter, Ben A; Nielsen, Rasmus; Rainville, Rebecca A; Orlando, Ludovic; Meltzer, David J; Kjær, Kurt H; Willerslev, Eske

2016-09-01

During the Last Glacial Maximum, continental ice sheets isolated Beringia (northeast Siberia and northwest North America) from unglaciated North America. By around 15 to 14 thousand calibrated radiocarbon years before present (cal. kyr bp), glacial retreat opened an approximately 1,500-km-long corridor between the ice sheets. It remains unclear when plants and animals colonized this corridor and it became biologically viable for human migration. We obtained radiocarbon dates, pollen, macrofossils and metagenomic DNA from lake sediment cores in a bottleneck portion of the corridor. We find evidence of steppe vegetation, bison and mammoth by approximately 12.6 cal. kyr bp, followed by open forest, with evidence of moose and elk at about 11.5 cal. kyr bp, and boreal forest approximately 10 cal. kyr bp. Our findings reveal that the first Americans, whether Clovis or earlier groups in unglaciated North America before 12.6 cal. kyr bp, are unlikely to have travelled by this route into the Americas. However, later groups may have used this north-south passageway.

AUXIN RESPONSE FACTOR17 Is Essential for Pollen Wall Pattern Formation in Arabidopsis1[C][W][OA

PubMed Central

Yang, Jun; Tian, Lei; Sun, Ming-Xi; Huang, Xue-Yong; Zhu, Jun; Guan, Yue-Feng; Jia, Qi-Shi; Yang, Zhong-Nan

2013-01-01

In angiosperms, pollen wall pattern formation is determined by primexine deposition on the microspores. Here, we show that AUXIN RESPONSE FACTOR17 (ARF17) is essential for primexine formation and pollen development in Arabidopsis (Arabidopsis thaliana). The arf17 mutant exhibited a male-sterile phenotype with normal vegetative growth. ARF17 was expressed in microsporocytes and microgametophytes from meiosis to the bicellular microspore stage. Transmission electron microscopy analysis showed that primexine was absent in the arf17 mutant, which leads to pollen wall-patterning defects and pollen degradation. Callose deposition was also significantly reduced in the arf17 mutant, and the expression of CALLOSE SYNTHASE5 (CalS5), the major gene for callose biosynthesis, was approximately 10% that of the wild type. Chromatin immunoprecipitation and electrophoretic mobility shift assays showed that ARF17 can directly bind to the CalS5 promoter. As indicated by the expression of DR5-driven green fluorescent protein, which is an synthetic auxin response reporter, auxin signaling appeared to be specifically impaired in arf17 anthers. Taken together, our results suggest that ARF17 is essential for pollen wall patterning in Arabidopsis by modulating primexine formation at least partially through direct regulation of CalS5 gene expression. PMID:23580594

Vegetation, fire, climate and human disturbance history in the southwestern Mediterranean area during the late Holocene

NASA Astrophysics Data System (ADS)

Jiménez-Moreno, Gonzalo; García-Alix, Antonio; Hernández-Corbalán, María Dolores; Anderson, R. Scott; Delgado-Huertas, Antonio

2013-03-01

Detailed pollen, charcoal, isotope and magnetic susceptibility data from an alpine lake sediment core from Sierra Nevada, southern Spain record changes in vegetation, fire history and lake sedimentation since ca. 4100 cal yr BP. The proxies studied record an arid period from ca. 3800 to 3100 cal yr BP characterized by more xerophytic vegetation and lower lake levels. A humid period is recorded between ca. 3100 and 1850 cal yr BP, which occurred in two steps: (1) an increase in evergreen Quercus between 3100 and 2500 cal yr BP, indicating milder conditions than previously and (2) an increase in deciduous Quercus and higher lake levels, between ca. 2500 and 1850 cal yr BP, indicating a further increase in humidity and reduction in seasonal contrast. Humid maxima occurred during the Roman Humid Period, previously identified in other studies in the Mediterranean region. Intensified fire activity at this time could be related to an increase in fuel load and/or in human disturbance. An arid period subsequently occurred between 1850 and 650 cal yr BP, though a decrease in Quercus and an increase in xerophytes. The alternation of persistent North Atlantic Oscillation modes probably played an important role in controlling these humid-arid cycles.

Holocene vegetation and climate change recorded in alpine bog sediments from the Borreguiles de la Virgen, Sierra Nevada, southern Spain

NASA Astrophysics Data System (ADS)

Jiménez-Moreno, Gonzalo; Anderson, R. Scott

2012-01-01

High-resolution pollen and magnetic susceptibility (MS) analyses have been carried out on a sediment core taken from a high-elevation alpine bog area located in Sierra Nevada, southern Spain. The earliest part of the record, from 8200 to about 7000 cal yr BP, is characterized by the highest abundance of arboreal pollen and Pediastrum, indicating the warmest and wettest conditions in the area at that time. The pollen record shows a progressive aridification since 7000 cal yr BP that occurred in two steps, first shown by a decrease in Pinus, replaced by Poaceae from 7000 to 4600 cal yr BP and then by Cyperaceae, Artemisia and Amaranthaceae from 4600 to 1200 cal yr BP. Pediastrum also decreased progressively and totally disappeared at ca. 3000 yr ago. The progressive aridification is punctuated by periodically enhanced drought at ca. 6500, 5200 and 4000 cal yr BP that coincide in timing and duration with well-known dry events in the Mediterranean and other areas. Since 1200 cal yr BP, several changes are observed in the vegetation that probably indicate the high-impact of humans in the Sierra Nevada, with pasturing leading to nutrient enrichment and eutrophication of the bog, Pinus reforestation and Olea cultivation at lower elevations.

Equine Assisted Psychotherapy: The Equine Assisted Growth and Learning Association's Model Overview of Equine-Based Modalities

ERIC Educational Resources Information Center

Notgrass, Clayton G.; Pettinelli, J. Douglas

2015-01-01

This article describes the Equine Assisted Growth and Learning Association's (EAGALA) experiential model called "Equine Assisted Psychotherapy" (EAP). EAGALA's model is based on the Association for Experiential Education's (AEE) tenets and is focused on the learner's experience with horses. Drawing on the historical use of equines in the…

Survey on Intelligent Assistance for Workplace Learning in Software Engineering

NASA Astrophysics Data System (ADS)

Ras, Eric; Rech, Jörg

Technology-enhanced learning (TEL) systems and intelligent assistance systems aim at supporting software engineers during learning and work. A questionnaire-based survey with 89 responses from industry was conducted to find out what kinds of services should be provided and how, as well as to determine which software engineering phases they should focus on. In this paper, we present the survey results regarding intelligent assistance for workplace learning in software engineering. We analyzed whether specific types of assistance depend on the organization's size, the respondent's role, and the experience level. The results show a demand for TEL that supports short-term problem solving and long-term competence development at the workplace.

An Investigation of the Relationship between College Chinese EFL Students' Autonomous Learning Capacity and Motivation in Using Computer-Assisted Language Learning

ERIC Educational Resources Information Center

Pu, Minran

2009-01-01

The purpose of the study was to investigate the relationship between college EFL students' autonomous learning capacity and motivation in using web-based Computer-Assisted Language Learning (CALL) in China. This study included three questionnaires: the student background questionnaire, the questionnaire on student autonomous learning capacity, and…

Holocene fire activity and vegetation response in South-Eastern Iberia

NASA Astrophysics Data System (ADS)

Gil-Romera, Graciela; Carrión, José S.; Pausas, Juli G.; Sevilla-Callejo, Miguel; Lamb, Henry F.; Fernández, Santiago; Burjachs, Francesc

2010-05-01

Since fire has been recognized as an essential disturbance in Mediterranean landscapes, the study of long-term fire ecology has developed rapidly. We have reconstructed a sequence of vegetation dynamics and fire changes across south-eastern Iberia by coupling records of climate, fire, vegetation and human activities. We calculated fire activity anomalies (FAAs) in relation to 3 ka cal BP for 10-8 ka cal BP, 6 ka cal BP, 4 ka cal BP and the present. For most of the Early to the Mid-Holocene uneven, but low fire events were the main vegetation driver at high altitudes where broadleaved and coniferous trees presented a highly dynamic post-fire response. At mid-altitudes in the mainland Segura Mountains, fire activity remained relatively stable, at similar levels to recent times. We hypothesize that coastal areas, both mountains and lowlands, were more fire-prone landscapes as biomass was more likely to have accumulated than in the inland regions, triggering regular fire events. The wet and warm phase towards the Mid-Holocene (between ca 8 and 6 ka cal BP) affected the whole region and promoted the spread of mesophytic forest co-existing with Pinus, as FAAs appear strongly negative at 6 ka cal BP, with a less important role of fire. Mid and Late Holocene landscapes were shaped by an increasing aridity trend and the rise of human occupation, especially in the coastal mountains where forest disappeared from ca 2 ka cal BP. Mediterranean-type vegetation (evergreen oaks and Pinus pinaster- halepensis types) showed the fastest post-fire vegetation dynamics over time.

CalA, a Cyanobacterial AbrB Protein, Interacts with the Upstream Region of hypC and Acts as a Repressor of Its Transcription in the Cyanobacterium Nostoc sp. Strain PCC 7120▿ †

PubMed Central

Agervald, Åsa; Zhang, Xiaohui; Stensjö, Karin; Devine, Ellenor; Lindblad, Peter

2010-01-01

The filamentous, heterocystous, nitrogen-fixing cyanobacterium Nostoc sp. strain PCC 7120 may contain, depending on growth conditions, up to two hydrogenases directly involved in hydrogen metabolism. HypC is one out of at least seven auxiliary gene products required for synthesis of a functional hydrogenase, specifically involved in the maturation of the large subunit. In this study we present a protein, CalA (Alr0946 in the genome), belonging to the transcription regulator family AbrB, which in protein-DNA assays was found to interact with the upstream region of hypC. Transcriptional investigations showed that calA is cotranscribed with the downstream gene alr0947, which encodes a putative protease from the abortive infection superfamily, Abi. CalA was shown to interact specifically not only with the upstream region of hypC but also with its own upstream region, acting as a repressor on hypC. The bidirectional hydrogenase activity was significantly downregulated when CalA was overexpressed, demonstrating a correlation with the transcription factor, either direct or indirect. In silico studies showed that homologues to both CalA and Alr0947 are highly conserved proteins within cyanobacteria with very similar physical organizations of the corresponding structural genes. Possible functions of the cotranscribed downstream protein Alr0947 are presented. In addition, we present a three-dimensional (3D) model of the DNA binding domain of CalA and putative DNA binding mechanisms are discussed. PMID:20023111

Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012.

PubMed

Chen, Jing-Jing; Ma, Xiao-Jing; Liu, Fang; Yan, Wei-Li; Huang, Mei-Rong; Huang, Min; Huang, Guo-Ying

2016-01-01

This study was to investigate the epidemiologic trends of Kawasaki disease (KD) and coronary arterial lesions (CALs) in Shanghai from 2008 through 2012. Data were collected by using the network of the KD research group established during the first survey in Shanghai to conduct the third survey, covering the period from 2008 through 2012. Clinical records of 2304 patients with acute KD were retrospectively reviewed. Epidemiologic features of KD were investigated. Univariate and multivariate analyses were performed to identify the risk factors for CAL in patients with KD. The data were compared with the previous 2 surveys covering the periods from 1998 to 2002 and 2003 to 2007, respectively. The average incidence of KD was 30.3 to 71.9 per 100,000 children aged 0-4 years from 2008 through 2012. Age at onset ranged from 32 days to 11.7 years (median: 2.3 years). The occurrence of KD was more common in summer and spring. A total of 365 (15.9%) cases developed CAL defined as ectasia or aneurysm. Male, age ≤ 1 year, intravenous immunoglobulin (IVIG) unresponsiveness, a smaller administrative dosage and the delayed administration of IVIG (>10 days) were independent risk factors for CAL. The occurrence of CAL seemed less frequent in patients who received IVIG within 5 days after onset of illness. The incidence of KD in children has increased over time, and the development of CAL decreased in the past 5 years in Shanghai. Earlier treatment with IVIG (<5 days) was associated with reduced CAL among patients with KD.

Climate change and human occupations in the Lake Daihai basin, north-central China over the last 4500 years: A geo-archeological perspective

NASA Astrophysics Data System (ADS)

Xu, Lichen; Liu, Yan; Sun, Qianli; Chen, Jing; Cheng, Peng; Chen, Zhongyuan

2017-05-01

High-resolution climate variations since the last 4500 years in the monsoonal-arid transition zone of north-central China were revealed through the integration of proxies from sediment cores in the Lake Daihai basin. Human occupations in the lake basin deduced from archeological findings and historical literatures were then incorporated into the climate sequence to demonstrate the patterns of human responses to the climate changes, and the recent anthropogenic effects. It indicated that: (1) Climate dominated human-environment adaptations prevailed prior to ∼2700 cal yr BP. An amicable climate setting before ∼4100 cal yr BP would facilitate the growth of the Laohushan Culture (LC) in the lake basin, while a pronounced deterioration of water thermal condition after that had led to human exodus and the collapse of the LC. The reduced human activity in the lake basin indicated at ∼3800-3500 cal yr BP and a subsequent cultural blank at ∼3500-2700 cal yr BP, were both in response to the climate and lake level fluctuations during ∼3800-2800 cal yr BP. (2) Transition to a positive human adaptation was seen at ∼2700-1100 cal yr BP, represented by the exploitation of arable land for cultivation and animal husbandry as the lake contracted. (3) An increasing human presence that affected environmental processes became more severe over the last ∼1100 cal yr BP. This was basically due to the ongoing lake shore reclamation for cropping, and more recently heavy metals emissions from fossil fuel combustion and local industries.

Comparative evaluation of probing depth and clinical attachment level using a manual probe and Florida probe.

PubMed

Kour, Amandeep; Kumar, Ashish; Puri, Komal; Khatri, Manish; Bansal, Mansi; Gupta, Geeti

2016-01-01

To compare and evaluate the intra- and inter-examiner efficacy and reproducibility of the first-generation manual (Williams) probe and the third-generation Florida probe in terms of measuring pocket probing depth (PD) and clinical attachment level (CAL). Forty subjects/4000 sites were included in this comparative, cross-sectional study. Group- and site-wise categorizations were done. Based on gingival index, PD, and CAL, patients were divided into four groups, i.e., periodontally healthy, gingivitis, mild to moderate periodontitis, and severe periodontitis. Further, based on these parameters, a total of 4000 sites, with 1000 sites in each category randomly selected from these 40 patients, were taken. Full mouth PD and CAL measurements were recorded with two probes, by Examiner 1 and on Ramfjord teeth by Examiner 2. Full mouth and Ramfjord teeth group- and site-wise PD obtained with the manual probe by both the examiners were statistically significantly deeper than that obtained with the Florida probe. The full mouth and Ramfjord teeth mean CAL measurement by Florida probe was higher as compared to manual probe in mild to moderate periodontitis group and sites, whereas in severe periodontitis group and sites, manual probe recorded higher CAL as compared to Florida probe. Mean PD and CAL measurements were deeper with the manual probe as compared to the Florida probe in all the groups and sites, except for the mild-moderate periodontitis group and sites where the CAL measurements with the manual probe were less than the Florida probe. Manual probe was more reproducible and showed less interexaminer variability as compared to the Florida probe.

FlowCal: A user-friendly, open source software tool for automatically converting flow cytometry data from arbitrary to calibrated units

PubMed Central

Castillo-Hair, Sebastian M.; Sexton, John T.; Landry, Brian P.; Olson, Evan J.; Igoshin, Oleg A.; Tabor, Jeffrey J.

2017-01-01

Flow cytometry is widely used to measure gene expression and other molecular biological processes with single cell resolution via fluorescent probes. Flow cytometers output data in arbitrary units (a.u.) that vary with the probe, instrument, and settings. Arbitrary units can be converted to the calibrated unit molecules of equivalent fluorophore (MEF) using commercially available calibration particles. However, there is no convenient, non-proprietary tool available to perform this calibration. Consequently, most researchers report data in a.u., limiting interpretation. Here, we report a software tool named FlowCal to overcome current limitations. FlowCal can be run using an intuitive Microsoft Excel interface, or customizable Python scripts. The software accepts Flow Cytometry Standard (FCS) files as inputs and is compatible with different calibration particles, fluorescent probes, and cell types. Additionally, FlowCal automatically gates data, calculates common statistics, and produces publication quality plots. We validate FlowCal by calibrating a.u. measurements of E. coli expressing superfolder GFP (sfGFP) collected at 10 different detector sensitivity (gain) settings to a single MEF value. Additionally, we reduce day-to-day variability in replicate E. coli sfGFP expression measurements due to instrument drift by 33%, and calibrate S. cerevisiae mVenus expression data to MEF units. Finally, we demonstrate a simple method for using FlowCal to calibrate fluorescence units across different cytometers. FlowCal should ease the quantitative analysis of flow cytometry data within and across laboratories and facilitate the adoption of standard fluorescence units in synthetic biology and beyond. PMID:27110723

L-type calcium channels refine the neural population code of sound level

PubMed Central

Grimsley, Calum Alex; Green, David Brian

2016-01-01

The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks. Voltage-gated conductances alter local output by regulating neuronal firing, but their role in modulating responses to sound level is unclear. We tested the effects of L-type calcium channels (CaL: CaV1.1–1.4) on sound-level coding in the central nucleus of the inferior colliculus (ICC) in the auditory midbrain. We characterized the contribution of CaL to the total calcium current in brain slices and then examined its effects on rate-level functions (RLFs) in vivo using single-unit recordings in awake mice. CaL is a high-threshold current and comprises ∼50% of the total calcium current in ICC neurons. In vivo, CaL activates at sound levels that evoke high firing rates. In RLFs that increase monotonically with sound level, CaL boosts spike rates at high sound levels and increases the maximum firing rate achieved. In different populations of RLFs that change nonmonotonically with sound level, CaL either suppresses or enhances firing at sound levels that evoke maximum firing. CaL multiplies the gain of monotonic RLFs with dynamic range and divides the gain of nonmonotonic RLFs with the width of the RLF. These results suggest that a single broad class of calcium channels activates enhancing and suppressing local circuits to regulate the sensitivity of neuronal populations to sound level. PMID:27605536

Reflexes in the shoulder muscles elicited from the human coracoacromial ligament.

PubMed

Diederichsen, Louise Pyndt; Nørregaard, Jesper; Krogsgaard, Michael; Fischer-Rasmussen, Torsten; Dyhre-Poulsen, Poul

2004-09-01

Morphological studies have demonstrated mechanoreceptors in the capsuloligamentous structures of the shoulder joint, however knowledge of the role these joint receptors play in the control of shoulder stability is limited. We therefore investigated the effect of electrically induced afferent activity from mechanoreceptors in the coracoacromial ligament (CAL) on the activity of voluntary activated shoulder muscles in healthy humans. In study I, wire electrodes, for electrical stimulation, were inserted into the CAL in eight normal shoulders. In study II, a needle electrode was inserted into the CAL in seven normal shoulders. Electric activity was recorded from eight shoulder muscles by surface and intramuscular electrodes. During isometric contractions, electrical stimulation was applied to the CAL at two different stimulus intensities, a weak stimulus (stim-1) and a stronger stimulus (stim-2). In both experiments, electrical stimulation of the CAL elicited a general inhibition in the voluntary activated shoulder muscles. In study I the average latencies (mean+/-SE) of the muscular inhibition were 66+/-4 ms (stim-1) and 62+/-4 ms (stim-2) during isometric flexion and 73+/-3 ms (stim-1) and 73+/-5 ms (stim-2) during isometric extension. In study II the average latency (mean+/-SE) of the response was 66+/-4 ms (stim-1) during isometric flexion. Our results demonstrated a response, probably of reflex origin, from mechanoreceptors in the CAL to the shoulder muscles. The existence of this synaptic connection between mechanoreceptors in CAL and the shoulder muscles suggest a role of these receptors in muscle coordination and in the functional joint stability.

Microshear Bond Strength of Tri-Calcium Silicate-based Cements to Different Restorative Materials.

PubMed

Cengiz, Esra; Ulusoy, Nuran

To evaluate the microshear bond strength of tri-calcium silicate-based materials to different restorative materials. Thirty-five disks of TheraCal LC and Biodentine were fabricated using teflon molds according to manufacturers' instructions. Then the specimens were randomly divided into 7 groups according to the materials applied: Fuji IX, Fuji II, Equia Fil, Vertise Flow, Filtek Bulk Fill Posterior Restorative, Filtek Z250 with Prime&Bond NT and with Clearfil SE Bond. All restorative materials were placed onto the disks using tygon tubes. Following a storage period, the specimens underwent microshear bond strength testing in a universal testing machine, and fracture modes were analyzed. Data were analyzed using one-way ANOVA and Tukey's post-hoc test. For all restorative materials, TheraCal LC showed significantly higher μSBS values compared to Biodentine. GIC based materials showed the lowest μSBS for TheraCal and Biodentine. For Biodentine, Filtek Z250 applied with Prime&Bond NT and Filtek Bulk Fill Posterior Restorative applied with Scotchbond Universal Adhesive exhibited the highest μSBS, while Filtek Z250 applied with Clearfil SE Bond revealed the highest bond strength to TheraCal LC. For all restorative materials tested in this study, TheraCal LC showed higher μSBS compared to Biodentine. For both TheraCal LC and Biodentine, the placement of GIC-based materials prior to composite resin restorations might decrease the bond strength. Composite resins applied with self-etching adhesives increased the bond strength of TheraCal LC; however, for Biodentine, application of etch-and-rinse adhesives may improve the adhesion of composite resins.

Holocene East Asian Monsoon Variability: Links to Solar and Tropical Pacific Forcing

NASA Astrophysics Data System (ADS)

Kandasamy, S.; Chen, C. A.; Lou, J.

2006-12-01

Sedimentary geochemical records from subalpine Retreat Lake, subtropical Taiwan, document the unstable East Asian Monsoon (EAM) climate for the last ~10250 calendar years before the present (cal yr B.P.). The proxy records demonstrate cool, glacial conditions with weak EAM between ~10250 and 8640 cal yr B.P., the strongest EAM during the "Holocene optimum" (8640-4500 cal yr B.P.) with an abrupt, decadal onset of postglacial EAM (8640-8600 cal yr B.P.), and relatively dry conditions since 4500 cal yr B.P. Although after 8600 cal yr B.P., EAM strength reduces gradually in response to the Northern Hemisphere summer insolation, heat and moisture transport and the development of late Holocene El-Niño-Southern Oscillation in the tropical Pacific appear to corroborate the periods of abrupt monsoon changes. Our proxy records reveal several weak monsoon intervals that correlate to low sea surface temperatures in the western tropical Pacific and cold events in the North Atlantic, suggesting a mechanistic link. Among those, four weak EAM events at 8170, 5400, 4500-2100 and 2000-1600 cal yr B.P. are in phase with the timings of low concentrations of atmospheric methane and periods of reduced North Atlantic Deep Water production as well as the `8.2 ka cold spell' and widespread event of low-latitude cultural collapse. Our EAM records exhibit strong correlations with high- and low-latitude climate and monsoon records; thus, provide robust evidences that the centennial-millennial scale monsoon variability during the Holocene are globally-mediated via sun- ocean-monsoon-North Atlantic linkages.

Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice.

PubMed

Ku, Kuo-Lung; Tsai, Chu-Tsai; Chang, Wei-Min; Shen, Mei-Lin; Wu, Chia-Tien; Liao, Hui-Fen

2008-01-01

Cirsium arisanense Kitamura (Compositae) has been used for hundreds of years in Taiwan as a folk medicine for hepatoprotection. However, no scientific research has demonstrated this effect. In the present study, we extracted the phenol-containing aqueous components of C. arisanense roots (CaR) and leaves/stem (CaL), and then assessed their hepatoprotective activities in both human hepatocellular carcinoma Hep 3B cells and C57BL/6 mice strain. High performance liquid chromatography (HPLC) analysis revealed that the components of CaR and CaL differed from those of the positive control silymarin. CaR exhibited a higher phenolic content and antioxidant capacity than CaL. Hep 3B cells treated with silymarin (0-200 microg/ml) demonstrated a concentration-dependent decrease in viability; however, both CaR and CaL did not exhibit any apparent cytotoxicity. Silymarin at 100 microg/ml, as well as CaR and CaL, not only protect Hep 3B cells from tacrine-induced hepatotoxicity but also decrease the expression of hepatitis B surface antigen (HBsAg). Moreover, an animal experiment demonstrated that CaR, CaL, and silymarin have hepatoprotective effects in C57BL/6 mice injected with tacrine, and they significantly decrease the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST). These effects of CaR and silymarin, but not of CaL, may occur via an increase in the hepatic glutathione level and the elimination of the nitric oxide production. In conclusion, the phenol-containing aqueous components from C. arisanense have potential in hepatoprotection.

Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam Compared with Betamethasone 17-Valerate-Medicated Plaster for the Treatment of Psoriasis.

PubMed

Queille-Roussel, Catherine; Rosen, Monika; Clonier, Fabrice; Nørremark, Kasper; Lacour, Jean-Philippe

2017-04-01

Fixed combination calcipotriol as hydrate (Cal) 50 µg/g plus betamethasone as dipropionate (BD) 0.5 mg/g aerosol foam is an alcohol-free treatment for psoriasis. Betamethasone 17-valerate 2.25 mg (BV)-medicated plasters are recommended for treating psoriasis plaques localized in difficult-to-treat (DTT; elbow, knee, anterior face of the tibia) areas. The aim of this study was to compare the efficacy of Cal/BD foam with BV-medicated plaster in patients with plaque psoriasis. In this phase IIa, randomized, single-center, investigator-blinded, 4-week study, both Cal/BD foam and BV-medicated plaster were applied once daily to six test sites (three for each treatment). The primary efficacy endpoint was absolute change in total clinical score (TCS; sum of erythema, scaling, and infiltration); secondary endpoints were changes from baseline in each individual clinical score, ultrasonographic changes (total skin and echo-poor band thickness), and safety; and post hoc analysis was change from baseline in TCS on DTT areas. Thirty-five patients were included. Least-squares mean change in TCS from baseline was significantly greater for Cal/BD foam (-5.8) than BV-medicated plaster (-3.7; difference -2.2; 95% confidence interval -2.6 to -1.8; p < 0.001); greater changes for Cal/BD foam were observed from day 8 for each clinical sign. Absolute total skin and echo-poor band thickness change was significantly greater for Cal/BD foam than for BV-medicated plaster (both p < 0.001). Post hoc analyses showed that Cal/BD foam was significantly more effective than BV-medicated plaster on DTT areas after 4 weeks (p < 0.001), and both treatments were well tolerated. Cal/BD foam demonstrated superior efficacy versus BV-medicated plasters, including on DTT areas, in patients with plaque psoriasis. NCT02518048.

Decrease of tight junction integrity in the ipsilateral thalamus during the acute stage after focal infarction and ablation of the cerebral cortex in rats.

PubMed

Li, Jing-Jing; Xing, Shi-Hui; Zhang, Jian; Hong, Hua; Li, Yi-Liang; Dang, Chao; Zhang, Yu-Sheng; Li, Chuo; Fan, Yu-Hua; Yu, Jian; Pei, Zhong; Zeng, Jin-Sheng

2011-11-01

1. Whether damage to the blood-brain barrier (BBB) occurs in remote areas after a focal cortical lesion remains unknown. The present study investigated tight junction-related proteins and tight junction microstructure in the ipsilateral thalamus during the acute stage after middle cerebral artery occlusion (MCAO) and cortical aspiration lesion (CAL) in rats. 2. Thirty-six hypertensive and normotensive rats were subjected to MCAO or CAL; another 18 rats in each group were submitted to sham operation. Zonula Occluden (ZO)-1, occludin and albumin were detected by western blotting 12 and 24 h after surgery. Tight junction microstructure was evaluated using electron microscopy, whereas albumin location in the ipsilateral thalamus was determined using double immunostaining for albumin and occludin or albumin and neuronal nuclei (NeuN) 24 h after surgery. 3. Twenty-four hours after MCAO or CAL, occludin expression was reduced to 78.4% and 81.3%, respectively, compared with control. A reduction in ZO-1 expression in the ipsilateral thalamus (to 79%) was seen only after CAL (P < 0.05). Membrane contact at the tight junction was discontinuous in the ipsilateral thalamus in both MCAO and CAL rats. Albumin levels were 23.2% and 82.5% higher in the ipsilateral thalamus after MCAO and CAL, respectively (P < 0.05). The percentage of the albumin-positive area that coincided with the occludin-positive area in the MCAO and CAL groups was 76.8% and 64.6%, respectively, indicating that albumin was mainly localized around the microvessels. 4. The results of the present study suggest that tight junction integrity decreases during the acute stage in the ipsilateral thalamus after MCAO and CAL in rats. © 2011 The Authors. Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.

Assistive Technologies for Reading

ERIC Educational Resources Information Center

Hasselbring, Ted S.; Bausch, Margaret E.

2006-01-01

Although approximately half of the six million students receiving specialized services for an identified disability are learning disabled, research shows that assistive technologies are far more commonly used with students who manifest physical or sensory disabilities than they are with those with learning disabilities. Assistive technology can…

Teaching to Learn: Analyzing the Experiences of First-Time Physics Learning Assistants

ERIC Educational Resources Information Center

Gray, Kara Elizabeth

2013-01-01

The Colorado Learning Assistant (LA) Model has demonstrated that it is successful in helping to meet multiple goals including enhancing student learning in LA-supported courses, increasing conceptual understanding of physics among LAs, and improving the teaching practices of former LAs in K-12 schools. The research reported here investigated the…

Mobile-Assisted Vocabulary Learning: A Review Study

ERIC Educational Resources Information Center

Afzali, Parichehr; Shabani, Somayeh; Basir, Zohreh; Ramazani, Mohammad

2017-01-01

Mobile phones are becoming more acceptable toolkits to learn languages. One aspect of English language which has been subject to investigation in mobile-assisted language learning (MALL) is vocabulary. This study reviewed some of the studies conducted in various contexts on the effect of MALL on vocabulary learning. We investigated some of the…

The Relationship between the Learning Strategies and Learning Styles in a Hypermedia Environment.

ERIC Educational Resources Information Center

Liu, Min; Reed, W. Michael

Different learning strategies that are used by field-independent (FI) and field-dependent (FD) people in a hypermedia-assisted instructional setting were studied with 63 international college students for whom English was a second language. The treatment was a semantic network-based hypermedia-assisted language-learning environment to help…

Facilitating Teachers' Reuse of Mobile Assisted Language Learning Resources Using Educational Metadata

ERIC Educational Resources Information Center

Zervas, Panagiotis; Sampson, Demetrios G.

2014-01-01

Mobile assisted language learning (MALL) and open access repositories for language learning resources are both topics that have attracted the interest of researchers and practitioners in technology enhanced learning (TeL). Yet, there is limited experimental evidence about possible factors that can influence and potentially enhance reuse of MALL…

Computer-Assisted Language Learning: Diversity in Research and Practice

ERIC Educational Resources Information Center

Stockwell, Glenn, Ed.

2012-01-01

Computer-assisted language learning (CALL) is an approach to teaching and learning languages that uses computers and other technologies to present, reinforce, and assess material to be learned, or to create environments where teachers and learners can interact with one another and the outside world. This book provides a much-needed overview of the…

Student Conceptions of Peer-Assisted Learning

ERIC Educational Resources Information Center

Hodgson, Yvonne; Benson, Robyn; Brack, Charlotte

2015-01-01

This article reports on a programme in which peer-assisted learning (PAL) was combined with case-based learning (CBL) in a second-year radiologic biology unit of study. Our aim is to explore evidence of whether PAL supported the development of qualitative conceptions of learning. The programme involved students in small PAL groups preparing and…

From Teaching Assistant (TA) Training to Workplace Learning

ERIC Educational Resources Information Center

Korpan, Cynthia

2014-01-01

In this paper, I propose a renewed look at how teaching assistants (TAs) are being prepared to fulfill their duties in higher education. I argue that the apprenticeship model of learning that is currently in use be replaced by the more holistic workplace learning approach. Workplace learning theories take into consideration the complexity of the…

Mobile-Assisted Seamless Learning Activities in Higher Distance Education

ERIC Educational Resources Information Center

Amhag, Lisbeth

2017-01-01

Among online learning factors stated in the research literature, it is argued that online activities is the strongest factor which contributes to online learning. This article illuminates mobile-assisted seamless learning activities by using laptops, tablets, or smart phones. Two conditions are compared, a) face-to-face (F2F) online webinars…

An Intelligent Computer Assisted Language Learning System for Arabic Learners

ERIC Educational Resources Information Center

Shaalan, Khaled F.

2005-01-01

This paper describes the development of an intelligent computer-assisted language learning (ICALL) system for learning Arabic. This system could be used for learning Arabic by students at primary schools or by learners of Arabic as a second or foreign language. It explores the use of Natural Language Processing (NLP) techniques for learning…

Human-robot cooperative movement training: Learning a novel sensory motor transformation during walking with robotic assistance-as-needed

PubMed Central

Emken, Jeremy L; Benitez, Raul; Reinkensmeyer, David J

2007-01-01

Background A prevailing paradigm of physical rehabilitation following neurologic injury is to "assist-as-needed" in completing desired movements. Several research groups are attempting to automate this principle with robotic movement training devices and patient cooperative algorithms that encourage voluntary participation. These attempts are currently not based on computational models of motor learning. Methods Here we assume that motor recovery from a neurologic injury can be modelled as a process of learning a novel sensory motor transformation, which allows us to study a simplified experimental protocol amenable to mathematical description. Specifically, we use a robotic force field paradigm to impose a virtual impairment on the left leg of unimpaired subjects walking on a treadmill. We then derive an "assist-as-needed" robotic training algorithm to help subjects overcome the virtual impairment and walk normally. The problem is posed as an optimization of performance error and robotic assistance. The optimal robotic movement trainer becomes an error-based controller with a forgetting factor that bounds kinematic errors while systematically reducing its assistance when those errors are small. As humans have a natural range of movement variability, we introduce an error weighting function that causes the robotic trainer to disregard this variability. Results We experimentally validated the controller with ten unimpaired subjects by demonstrating how it helped the subjects learn the novel sensory motor transformation necessary to counteract the virtual impairment, while also preventing them from experiencing large kinematic errors. The addition of the error weighting function allowed the robot assistance to fade to zero even though the subjects' movements were variable. We also show that in order to assist-as-needed, the robot must relax its assistance at a rate faster than that of the learning human. Conclusion The assist-as-needed algorithm proposed here can limit error during the learning of a dynamic motor task. The algorithm encourages learning by decreasing its assistance as a function of the ongoing progression of movement error. This type of algorithm is well suited for helping people learn dynamic tasks for which large kinematic errors are dangerous or discouraging, and thus may prove useful for robot-assisted movement training of walking or reaching following neurologic injury. PMID:17391527

7 CFR 1703.101 - Policy.

Code of Federal Regulations, 2014 CFR

2014-01-01

... RURAL DEVELOPMENT Distance Learning and Telemedicine Loan and Grant Program-General § 1703.101 Policy... rural Americans. To further this objective, RUS will provide financial assistance to distance learning... educational, learning, training, and health care services. (b) In providing financial assistance, RUS will...

Pulse Height Analyzer Interfacing and Computer Programming in the Environmental Laser Propagation Project

DTIC Science & Technology

1976-06-01

United States Naval Postgraduate School, Monterey , California, 1974. 6. Anton , H., Elementary Linear Algebra , John Wiley & Sons, 1973. 7. Parrat, L. G...CONVERTER ln(laser & bias) PULSE HEIGHT ANALYZER © LINEAR AMPLIFIER SAMPLE TRIGGER OSCILLATOR early ln(laser & bias) SCINTILLOMETERS recent BACKGROUND...DEMODULATOR LASER CALIBRATION BOX LASER OR CAL VOLTAGE LOG CONVERTER LN (LASER OR CAL VOLT) LINEAR AMPLIFIER uLN (LASER OR CAL VOLT) PULSE HEIGHTEN ANALYZER V

Computer-Assisted Programmed Instruction in Textiles.

ERIC Educational Resources Information Center

Kean, Rita C.; Laughlin, Joan

Students in an introductory textiles course at the University of Nebraska's College of Home Economics actively participate in the learning experience through a self-paced instructional technique. Specific learning packets were developed adapting programmed instructional learning materials to computer assisted instruction (CAI). A study booklet…

Peer-Assisted Learning/Literacy Strategies. What Works Clearinghouse Intervention Report

ERIC Educational Resources Information Center

What Works Clearinghouse, 2012

2012-01-01

"Peer-Assisted Learning Strategies" and a similar program known as "Peer-Assisted Literacy Strategies" are peer-tutoring programs that supplement the primary reading curriculum (Fuchs, Fuchs, Kazdan, & Allen, 1999; Mathes & Babyak, 2001). This review uses the acronym "PALS" to encompass both programs and their…

Carbon Monoxide, Hydrogen, and Formate Metabolism during Methanogenesis from Acetate by Thermophilic Cultures of Methanosarcina and Methanothrix Strains.

PubMed

Zinder, S H; Anguish, T

1992-10-01

CO and H(2) have been implicated in methanogenesis from acetate, but it is unclear whether they are directly involved in methanogenesis or electron transfer in acetotrophic methanogens. We compared metabolism of H(2), CO, and formate by cultures of the thermophilic acetotrophic methanogens Methanosarcina thermophila TM-1 and Methanothrix sp. strain CALS-1. M. thermophila accumulated H(2) to partial pressures of 40 to 70 Pa (1 Pa = 0.987 x 10 atm), as has been previously reported for this and other Methanosarcina cultures. In contrast, Methanothrix sp. strain CALS-1 accumulated H(2) to maximum partial pressures near 1 Pa. Growing cultures of Methanothrix sp. strain CALS-1 initially accumulated CO, which reached partial pressures near 0.6 Pa (some CO came from the rubber stopper) during the middle of methanogenesis; this was followed by a decrease in CO partial pressures to less than 0.01 Pa by the end of methanogenesis. Accumulation or consumption of CO by cultures of M. thermophila growing on acetate was not detected. Late-exponential-phase cultures of Methanothrix sp. strain CALS-1, in which the CO partial pressure was decreased by flushing with N(2)-CO(2), accumulated CO to 0.16 Pa, whereas cultures to which ca. 0.5 Pa of CO was added consumed CO until it reached this partial pressure. Cyanide (1 mM) blocked CO consumption but not production. High partial pressures of H(2) (40 kPa) inhibited methanogenesis from acetate by M. thermophila but not by Methanothrix sp. strain CALS-1, and 2 kPa of CO was not inhibitory to M. thermophila but was inhibitory to Methanothrix sp. strain CALS-1. Levels of CO dehydrogenase, hydrogenase, and formate dehydrogenase in Methanothrix sp. strain CALS-1 were 9.1, 0.045, and 5.8 mumol of viologen reduced min mg of protein. These results suggest that CO plays a role in Methanothrix sp. strain CALS-1 similar to that of H(2) in M. thermophila and are consistent with the conclusion that CO is an intermediate in a catabolic or anabolic pathway in Methanothrix sp. strain CALS-1; however, they could also be explained by passive equilibration of CO with a metabolic intermediate.

Carbon Monoxide, Hydrogen, and Formate Metabolism during Methanogenesis from Acetate by Thermophilic Cultures of Methanosarcina and Methanothrix Strains

PubMed Central

Zinder, S. H.; Anguish, T.

1992-01-01

CO and H2 have been implicated in methanogenesis from acetate, but it is unclear whether they are directly involved in methanogenesis or electron transfer in acetotrophic methanogens. We compared metabolism of H2, CO, and formate by cultures of the thermophilic acetotrophic methanogens Methanosarcina thermophila TM-1 and Methanothrix sp. strain CALS-1. M. thermophila accumulated H2 to partial pressures of 40 to 70 Pa (1 Pa = 0.987 × 10-5 atm), as has been previously reported for this and other Methanosarcina cultures. In contrast, Methanothrix sp. strain CALS-1 accumulated H2 to maximum partial pressures near 1 Pa. Growing cultures of Methanothrix sp. strain CALS-1 initially accumulated CO, which reached partial pressures near 0.6 Pa (some CO came from the rubber stopper) during the middle of methanogenesis; this was followed by a decrease in CO partial pressures to less than 0.01 Pa by the end of methanogenesis. Accumulation or consumption of CO by cultures of M. thermophila growing on acetate was not detected. Late-exponential-phase cultures of Methanothrix sp. strain CALS-1, in which the CO partial pressure was decreased by flushing with N2-CO2, accumulated CO to 0.16 Pa, whereas cultures to which ca. 0.5 Pa of CO was added consumed CO until it reached this partial pressure. Cyanide (1 mM) blocked CO consumption but not production. High partial pressures of H2 (40 kPa) inhibited methanogenesis from acetate by M. thermophila but not by Methanothrix sp. strain CALS-1, and 2 kPa of CO was not inhibitory to M. thermophila but was inhibitory to Methanothrix sp. strain CALS-1. Levels of CO dehydrogenase, hydrogenase, and formate dehydrogenase in Methanothrix sp. strain CALS-1 were 9.1, 0.045, and 5.8 μmol of viologen reduced min-1 mg of protein-1. These results suggest that CO plays a role in Methanothrix sp. strain CALS-1 similar to that of H2 in M. thermophila and are consistent with the conclusion that CO is an intermediate in a catabolic or anabolic pathway in Methanothrix sp. strain CALS-1; however, they could also be explained by passive equilibration of CO with a metabolic intermediate. PMID:16348788

The Edinburgh Electronic Veterinary Curriculum: an online program-wide learning and support environment for veterinary education.

PubMed

Ellaway, Rachel; Pettigrew, Graham; Rhind, Susan; Dewhurst, David

2005-01-01

The Edinburgh Electronic Veterinary Curriculum (EEVeC) is a purpose-built virtual learning support environment for the veterinary medicine program at the University of Edinburgh. It is Web based and adapted from a system developed for the human medical curriculum. It is built around a set of databases and learning objects and incorporates features such as course materials, personalized timetables, staff and student contact pages, a notice board, and discussion forums. The EEVeC also contains global or generic resources such as information on quality enhancement and research options. Many of these features contribute to the aim of building a learning community, but a challenge has been to introduce specific features that enhance student learning. One of these is a searchable lecture database in which learning activities such as quizzes and computer-aided learning exercises (CALs) can be embedded to supplement a synopsis of the lecture and address the key needs of integration and reinforcement of learning. Statistics of use indicate extensive student activity during evenings and weekends, with a pattern of increased usage over the years as more features become available and staff and students progressively engage with the system. An essential feature of EEVeC is its flexibility and the way in which it is evolving to meet the changing needs of the teaching program.

A Seamless Learning Design for Mobile Assisted Language Learning: An Iranian Context

ERIC Educational Resources Information Center

Foomani, Elham Mohammadi; Hedayati, Mohsen

2016-01-01

Recent developments in information communication technology (ICT) have resulted in a paradigm shift in e-Learning and there is a growing interest in developing design-based research (DBR) focusing on learners and their involvement in knowledge sharing in a contextualized mode. The present study reports a mobile-assisted language learning (MALL)…

How Artefacts Mediate Small-Group Co-Creation Activities in a Mobile-Assisted Seamless Language Learning Environment?

ERIC Educational Resources Information Center

Wong, L. -H.; Chen, W.; Jan, M.

2012-01-01

The rich learning resources and contexts learners experience in their everyday life could play important roles in complementing formal learning, but are often neglected by learners and teachers. In this paper, we present an intervention study in "Move, Idioms!", a mobile-assisted Chinese language learning approach that emphasizes contextualized…

On Using Intelligent Computer-Assisted Language Learning in Real-Life Foreign Language Teaching and Learning

ERIC Educational Resources Information Center

Amaral, Luiz A.; Meurers, Detmar

2011-01-01

This paper explores the motivation and prerequisites for successful integration of Intelligent Computer-Assisted Language Learning (ICALL) tools into current foreign language teaching and learning (FLTL) practice. We focus on two aspects, which we argue to be important for effective ICALL system development and use: (i) the relationship between…

Computer-Assisted Language Learning (CALL) in Support of (Re)-Learning Native Languages: The Case of Runyakitara

ERIC Educational Resources Information Center

Katushemererwe, Fridah; Nerbonne, John

2015-01-01

This study presents the results from a computer-assisted language learning (CALL) system of Runyakitara (RU_CALL). The major objective was to provide an electronic language learning environment that can enable learners with mother tongue deficiencies to enhance their knowledge of grammar and acquire writing skills in Runyakitara. The system…

Analysis of Students' After-School Mobile-Assisted Artifact Creation Processes in a Seamless Language Learning Environment

ERIC Educational Resources Information Center

Wong, Lung-Hsiang

2013-01-01

As part of a learner's learning ecology, the informal, out-of-school settings offer virtually boundless opportunities to advance one's learning. This paper reports on "Move, Idioms!", a design for Mobile-Assisted Language Learning experience that accentuates learners' habit of mind and skills in making meaning with their daily…

Your Verbal Zone: An Intelligent Computer-Assisted Language Learning Program in Support of Turkish Learners' Vocabulary Learning

ERIC Educational Resources Information Center

Esit, Omer

2011-01-01

This study investigated the effectiveness of an intelligent computer-assisted language learning (ICALL) program on Turkish learners' vocabulary learning. Within the scope of this research, an ICALL application with a morphological analyser (Your Verbal Zone, YVZ) was developed and used in an English language preparatory class to measure its…

Re-Exploring Game-Assisted Learning Research: The Perspective of Learning Theoretical Bases

ERIC Educational Resources Information Center

Wu, Wen-Hsiung; Chiou, Wen-Bin; Kao, Hao-Yun; Hu, Chung-Hsing Alex; Huang, Sih-Han

2012-01-01

Previous literature reviews or meta-analysis based studies on game-assisted learning have provided important results, but few studies have considered the importance of learning theory, and coverage of papers after 2007 is scant. This study presents a systematic review of the literature using a meta-analysis approach to provide a more comprehensive…

Can Apple's iPhone Help to Improve English Pronunciation Autonomously? State of the App

ERIC Educational Resources Information Center

González, Jonás Fouz

2012-01-01

This paper is part of a larger project that examines some of the best-selling iPhone apps designed to learn English pronunciation. Informed by the literature on pronunciation teaching/acquisition, Computer Assisted Pronunciation Teaching (CAPT), Computer Assisted Language Learning (CALL) and Mobile-learning (M-learning), it provides a critical…

Learning Styles of Physical Therapy and Physical Therapy Assistant Students in Accredited Physical Therapy Programs

ERIC Educational Resources Information Center

Lowdermilk, Margaret; Lampley, Jim; Tweed, Stephanie

2017-01-01

The purpose of this study was to determine the learning styles of Doctor of Physical Therapy (DPT) students and associate degree Physical Therapist Assistant (PTA) students and identify any association between their learning styles and examine the association between gender and age by learning style. Participants included 337 DPT and PTA students…

Authoring Robot-Assisted Instructional Materials for Improving Learning Performance and Motivation in EFL Classrooms

ERIC Educational Resources Information Center

Hong, Zeng-Wei; Huang, Yueh-Min; Hsu, Marie; Shen, Wei-Wei

2016-01-01

Anthropomorphized robots are regarded as beneficial tools in education due to their capabilities of improving teaching effectiveness and learning motivation. Therefore, one major trend of research, known as Robot- Assisted Language Learning (RALL), is trying to develop robots to support teaching and learning English as a foreign language (EFL). As…

Effects of ICT Assisted Real and Virtual Learning on the Performance of Secondary School Students

ERIC Educational Resources Information Center

Deka, Monisha; Jena, Ananta Kumar

2017-01-01

The study aimed to assess the effect of ICT assisted real and virtual learning performance over the traditional approach of secondary school students. Non-Equivalent Pretest-Posttest Quasi Experimental Design used to assess and relate the effects of independent variables virtual learning on dependent variables (i.e. learning performance).…

Providing Hearing-Impaired Students with Learning Care after Classes through Smart Phones and the GPRS Network

ERIC Educational Resources Information Center

Liu, Chen-Chung; Hong, Yi-Ching

2007-01-01

Although computers and network technology have been widely utilised to assist students learn, few technical supports have been developed to help hearing-impaired students learn in Taiwan. A significant challenge for teachers is to provide after-class learning care and assistance to hearing-impaired students that sustain their motivation to…

My Pocket Technology: Introducing a Mobile Assisted Inquiry Learning Environment (MAILE) to Promote Inquiries among Secondary Students

ERIC Educational Resources Information Center

Leelamma, Sreelekha; Indira, Uma Devi

2017-01-01

This paper introduces the Mobile Assisted Inquiry Learning Environment (MAILE), an Experimental Instructional Strategy (EIS) which employs an inquiry-based learning approach to guide secondary school students to learn environmental science in an engaging way supported by mobile phones. The students are situated in both the real world and the…

Implementation of a Learning Assistant Program Improves Student Performance on Higher-Order Assessments

ERIC Educational Resources Information Center

Sellami, Nadia; Shaked, Shanna; Laski, Frank A.; Eagan, Kevin M.; Sanders, Erin R.

2017-01-01

Learning assistant (LA) programs have been implemented at a range of institutions, usually as part of a comprehensive curricular transformation accompanied by a pedagogical switch to active learning. While this shift in pedagogy has led to increased student learning gains, the positive effect of LAs has not yet been distinguished from that of…

Doing Dissections Differently: A Structured, Peer-Assisted Learning Approach to Maximizing Learning in Dissections

ERIC Educational Resources Information Center

Hall, Emma R.; Davis, Rachel C.; Weller, Renate; Powney, Sonya; Williams, Sarah B.

2013-01-01

Areas of difficulty faced by our veterinary medicine students, with respect to their learning in dissection classes, were identified. These challenges were both general adult-learning related and specific to the discipline of anatomy. Our aim was to design, implement, and evaluate a modified reciprocal peer-assisted/team-based learning…

Effects of different forms of physiology instruction on the development of students' conceptions of and approaches to science learning.

PubMed

Lin, Yi-Hui; Liang, Jyh-Chong; Tsai, Chin-Chung

2012-03-01

The purpose of this study was to investigate students' conceptions of and approaches to learning science in two different forms: internet-assisted instruction and traditional (face-to-face only) instruction. The participants who took part in the study were 79 college students enrolled in a physiology class in north Taiwan. In all, 46 of the participants were from one class and 33 were from another class. Using a quasi-experimental research approach, the class of 46 students was assigned to be the "internet-assisted instruction group," whereas the class of 33 students was assigned to be the "traditional instruction group." The treatment consisted of a series of online inquiry activities. To explore the effects of different forms of instruction on students' conceptions of and approaches to learning science, two questionnaires were administered before and after the instruction: the Conceptions of Learning Science Questionnaire and the Approaches to Learning Science Questionnaire. Analysis of covariance results revealed that the students in the internet-assisted instruction group showed less agreement than the traditional instruction group in the less advanced conceptions of learning science (such as learning as memorizing and testing). In addition, the internet-assisted instruction group displayed significantly more agreement than the traditional instruction group in more sophisticated conceptions (such as learning as seeing in a new way). Moreover, the internet-assisted instruction group expressed more orientation toward the approaches of deep motive and deep strategy than the traditional instruction group. However, the students in the internet-assisted instruction group also showed more surface motive than the traditional instruction group did.

USS Cal Builders, Inc. Information Sheet

EPA Pesticide Factsheets

USS Cal Builders, Inc. (the Company) is located in Stanton, California. The settlement involves renovation activities conducted at property constructed prior to 1978, located in San Francisco, California.

Automatic health record review to help prioritize gravely ill Social Security disability applicants.

PubMed

Abbott, Kenneth; Ho, Yen-Yi; Erickson, Jennifer

2017-07-01

Every year, thousands of patients die waiting for disability benefits from the Social Security Administration. Some qualify for expedited service under the Compassionate Allowance (CAL) initiative, but CAL software focuses exclusively on information from a single form field. This paper describes the development of a supplemental process for identifying some overlooked but gravely ill applicants, through automatic annotation of health records accompanying new claims. We explore improved prioritization instead of fully autonomous claims approval. We developed a sample of claims containing medical records at the moment of arrival in a single office. A series of tools annotated both patient records and public Web page descriptions of CAL medical conditions. We trained random forests to identify CAL patients and validated each model with 10-fold cross validation. Our main model, a general CAL classifier, had an area under the receiver operating characteristic curve of 0.915. Combining this classifier with existing software improved sensitivity from 0.960 to 0.994, detecting every deceased patient, but reducing positive predictive value to 0.216. True positive CAL identification is a priority, given CAL patient mortality. Mere prioritization of the false positives would not create a meaningful burden in terms of manual review. Death certificate data suggest the presence of truly ill patients among putative false positives. To a limited extent, it is possible to identify gravely ill Social Security disability applicants by analyzing annotations of unstructured electronic health records, and the level of identification is sufficient to be useful in prioritizing case reviews. Published by Oxford University Press on behalf of the American Medical Informatics Association 2017. This work is written by US Government employees and is in the public domain in the US.

The Primacy of Multidecadal to Centennial Variability Over Late Holocene Forced Change of the Asian Monsoon on the Southern Tibetan Plateau

NASA Astrophysics Data System (ADS)

Conroy, J. L.; Hudson, A. M.; Overpeck, J. T.; Liu, K. B.; Luo, W.; Cole, J. E.

2016-12-01

The nature of multidecadal to centennial variability of the Asian monsoon remains largely unknown. Here we use the sediment record from a closed-basin lake in southern Tibet, Ngamring Tso, to assess summer monsoon precipitation from 4100 cal yr BP to present. The first principal component of the Ngamring Tso grain size record correlates significantly with observed June-September precipitation. From CE 1940-2007, grain size decreased with increasing summer precipitation and increased with decreasing summer precipitation. Satellite images of Ngamring Tso suggest precipitation-induced changes in lake depth or area likely govern grain size variability. Prolonged periods of weak summer monsoon precipitation occurred from 2800-2600 cal yr BP, 2500-2300 cal yr BP, and 1600-400 cal yr BP. A trend toward increased summer precipitation began around 1000 cal yr BP, with above-average summer precipitation from 400 cal yr BP to present, peaking between 200-100 cal yr BP. Dry and wet periods are coincident with dry and wet periods in other south-central Tibetan lake sediment records and with regional proxies of the ISM and EASM, indicating south-central Tibet is influenced by both monsoon subsystems. 20th century precipitation variability in southern Tibet falls within the range of natural variability in the last 4100 years, and does not show a clear trend of increasing precipitation as projected by models. Instead, it appears that poorly understood internal modes of monsoon variability remained influential throughout the last 4100 years. Substantial multidecadal to centennial-scale variability will thus complicate our ability to project future anthropogenic changes in the region's monsoon precipitation.

Skin tumor development after UV irradiation and photodynamic therapy is unaffected by short-term pretreatment with 5-fluorouracil, imiquimod and calcipotriol. An experimental hairless mouse study.

PubMed

Bay, Christiane; Togsverd-Bo, Katrine; Lerche, Catharina M; Haedersdal, Merete

2016-01-01

Photodynamic therapy (PDT) delays ultraviolet (UV) radiation-induced squamous cell carcinomas (SCCs) in hairless mice. Efficacy may be enhanced by combining PDT with antineoplastic or pro-differentiating agents. We investigated if pretreatment with 5-fluorouracil (5FU), imiquimod (IMIQ) or calcipotriol (CAL) before PDT further delays tumor onset. Hairless mice (n=224) were exposed 3 times weekly to 3 standard erythema doses (SED) of UV radiation. Methyl-aminolevulinate (MAL)-PDT sessions were given on days 45 and 90 before SCC development. Three applications of topical 5FU, IMIQ or CAL were given before each PDT session. Fluorescence photography quantified protoporphyrin IX (PpIX) formation. PDT delayed UV-induced SCC development by 59 days (212 days UV-MAL-PDT vs. 153 days UV-control, P<0.001). Pretreatment with 5FU, IMIQ or CAL before PDT did not further delay SCC onset compared to PDT alone (207 days UV-5FU-MAL-PDT, 215 days UV-IMIQ-MAL-PDT, 206 days UV-CAL-MAL-PDT vs. 212 days UV-MAL-PDT, P=ns). PpIX fluorescence intensified by 5FU-pretreatment (median 21,392 au UV-5FU-MAL-PDT, P=0.011), decreased after IMIQ-pretreatment (12,452 au UV-IMIQ-MAL-PDT, P<0.001), and was unaffected by CAL-pretreatment (19,567 au UV-CAL-MAL-PDT, P=ns) compared to MAL alone (18,083 au UV-MAL-PDT). Short-term three-day pretreatment with 5FU, IMIQ and CAL before PDT does not further delay tumor onset in UV-exposed hairless mice. Copyright © 2015 Elsevier B.V. All rights reserved.

Search for β2 Adrenergic Receptor Ligands by Virtual Screening via Grid Computing and Investigation of Binding Modes by Docking and Molecular Dynamics Simulations

PubMed Central

Bai, Qifeng; Shao, Yonghua; Pan, Dabo; Zhang, Yang; Liu, Huanxiang; Yao, Xiaojun

2014-01-01

We designed a program called MolGridCal that can be used to screen small molecule database in grid computing on basis of JPPF grid environment. Based on MolGridCal program, we proposed an integrated strategy for virtual screening and binding mode investigation by combining molecular docking, molecular dynamics (MD) simulations and free energy calculations. To test the effectiveness of MolGridCal, we screened potential ligands for β2 adrenergic receptor (β2AR) from a database containing 50,000 small molecules. MolGridCal can not only send tasks to the grid server automatically, but also can distribute tasks using the screensaver function. As for the results of virtual screening, the known agonist BI-167107 of β2AR is ranked among the top 2% of the screened candidates, indicating MolGridCal program can give reasonable results. To further study the binding mode and refine the results of MolGridCal, more accurate docking and scoring methods are used to estimate the binding affinity for the top three molecules (agonist BI-167107, neutral antagonist alprenolol and inverse agonist ICI 118,551). The results indicate agonist BI-167107 has the best binding affinity. MD simulation and free energy calculation are employed to investigate the dynamic interaction mechanism between the ligands and β2AR. The results show that the agonist BI-167107 also has the lowest binding free energy. This study can provide a new way to perform virtual screening effectively through integrating molecular docking based on grid computing, MD simulations and free energy calculations. The source codes of MolGridCal are freely available at http://molgridcal.codeplex.com. PMID:25229694

Paricalcitol Versus Calcifediol for Treating Hyperparathyroidism in Kidney Transplant Recipients.

PubMed

Cruzado, Josep M; Lauzurica, Ricardo; Pascual, Julio; Marcen, Roberto; Moreso, Francesc; Gutierrez-Dalmau, Alex; Andrés, Amado; Hernández, Domingo; Torres, Armando; Beneyto, Maria Isabel; Melilli, Edoardo; Manonelles, Anna; Arias, Manuel; Praga, Manuel

2018-01-01

Secondary hyperparathyroidism (SHPT) and vitamin D deficiency are common at kidney transplantation and are associated with some early and late complications. This study was designed to evaluate whether paricalcitol was more effective than nutritional vitamin D for controlling SHPT in de novo kidney allograft recipients. This was a 6-month, investigator-initiated, multicenter, open-label, randomized clinical trial. Patients with pretransplantation iPTH between 250 and 600 pg/ml and calcium <10 mg/dl were randomized to paricalcitol (PAR) or calcifediol (CAL). The intention-to-treat population (PAR: n = 46; CAL: n = 47) was used for the analysis. The primary endpoint was the percentage of patients with serum iPTH >110 pg/ml at 6 months. Secondary endpoints were bone mineral metabolism, renal function, and allograft protocol biopsies. The primary outcome occurred in 19.6% of patients in the PAR group and 36.2% of patients in the CAL group ( P  = 0.07). However, there was a higher percentage of patients with iPTH <70 pg/ml in the PAR group than in the CAL group (63.4% vs. 37.2%; P  = 0.03). No differences were observed in bone turnover biomarkers and bone mineral density. The estimated glomerular filtration rate was significantly higher in the CAL group than in the PAR group without differences in albuminuria. In protocol biopsies, interstitial fibrosis and tubular atrophy tended to be higher in the PAR group than in the CAL group (48% vs. 23.8%; P  = 0.09). Both medications were well tolerated. Both PAR and CAL reduced iPTH, but PAR was associated with a higher proportion of patients with iPTH <70 pg/ml. These results do not support the use of PAR to treat posttransplantation hyperparathyroidism.

Validation of learning style measures: implications for medical education practice.

PubMed

Chapman, Dane M; Calhoun, Judith G

2006-06-01

It is unclear which learners would most benefit from the more individualised, student-structured, interactive approaches characteristic of problem-based and computer-assisted learning. The validity of learning style measures is uncertain, and there is no unifying learning style construct identified to predict such learners. This study was conducted to validate learning style constructs and to identify the learners most likely to benefit from problem-based and computer-assisted curricula. Using a cross-sectional design, 3 established learning style inventories were administered to 97 post-Year 2 medical students. Cognitive personality was measured by the Group Embedded Figures Test, information processing by the Learning Styles Inventory, and instructional preference by the Learning Preference Inventory. The 11 subscales from the 3 inventories were factor-analysed to identify common learning constructs and to verify construct validity. Concurrent validity was determined by intercorrelations of the 11 subscales. A total of 94 pre-clinical medical students completed all 3 inventories. Five meaningful learning style constructs were derived from the 11 subscales: student- versus teacher-structured learning; concrete versus abstract learning; passive versus active learning; individual versus group learning, and field-dependence versus field-independence. The concurrent validity of 10 of 11 subscales was supported by correlation analysis. Medical students most likely to thrive in a problem-based or computer-assisted learning environment would be expected to score highly on abstract, active and individual learning constructs and would be more field-independent. Learning style measures were validated in a medical student population and learning constructs were established for identifying learners who would most likely benefit from a problem-based or computer-assisted curriculum.

Assault Tank T14

DTIC Science & Technology

1944-02-28

oal. machine gun mounted in the turret co» axially with t&e 75mm gun, a ,30 cal. machine gun mounted in the bow of the vehldle, and a .50 cal...openings should be larger. (2) jJJO cal, Co- axial Machine Gun and Mounti (a^ This jnin and mount functioned satisfactorily. (3) ^22 caJU Bow...ball Joint and too little clearance between the mounting pistes causes the mount to be very sticky and difficult to operate. (d^ The travel lock

Architectural Guidelines for Multimedia and Hypermedia Data Interchange: Computer Aided Acquisition and Logistics Support/Concurrent Engineering (CALS/ CE) and Electronic Commerce/Electronic Data Interchange (EC/EDI)

DTIC Science & Technology

1991-09-01

other networks . 69 For example, E-mail can be sent to an SNA network through a Softswitch gateway, but at a very slow rate. As discussed in Chapter III...10 6. Communication Protocols ..................... 10 D. NEW INFRASTRUCTURES ....................... 11 1. CALS Test Network (CTN...11 2. Industrial Networks ......................... 12 3. FTS-2000 and ISDN ........................ 12 4. CALS Operational Resource

M2 .50-cal. Multishot Capabilities at the US Army Research Laboratory

DTIC Science & Technology

2015-09-01

a platform was designed to simulate the 2-round burst of the M2 .50-caliber Browning machine gun (BMG). The 2-round-burst cyclic rate was achieved...ARL-TN-0694 ● SEP 2015 US Army Research Laboratory M2 .50-cal. Multishot Capabilities at the US Army Research Laboratory by...longer needed. Do not return it to the originator. ARL-TN-0694 ● SEP 2015 US Army Research Laboratory M2 .50-cal. Multishot

Electromagnetic Energy Absorption and Its Distribution for Man and Animals at Different Frequencies under Various Conditions.

DTIC Science & Technology

1978-11-01

the Proceedings of the IEEE (January 1980) Special Issue on Biologi - cal and Ecoigical Effects and Medical Applications of Electromag- netic Energy...prolate spheroidal and ellipsoidal equivalents of biologi - cal bodies, theoretical calculations have recently been given in a dosimetry handbook3 for...surface layers, e.g., skin, fat, muscle, which normally occur in biologi - cal bodies. It is found that the layering resonance for three-dimensional bodies

The PlusCal Algorithm Language

NASA Astrophysics Data System (ADS)

Lamport, Leslie

Algorithms are different from programs and should not be described with programming languages. The only simple alternative to programming languages has been pseudo-code. PlusCal is an algorithm language that can be used right now to replace pseudo-code, for both sequential and concurrent algorithms. It is based on the TLA + specification language, and a PlusCal algorithm is automatically translated to a TLA + specification that can be checked with the TLC model checker and reasoned about formally.

CYCLIN-DEPENDENT KINASE G1 Is Associated with the Spliceosome to Regulate CALLOSE SYNTHASE5 Splicing and Pollen Wall Formation in Arabidopsis[C][W][OA

PubMed Central

Huang, Xue-Yong; Niu, Jin; Sun, Ming-Xi; Zhu, Jun; Gao, Ju-Fang; Yang, Jun; Zhou, Que; Yang, Zhong-Nan

2013-01-01

Arabidopsis thaliana CYCLIN-DEPEDENT KINASE G1 (CDKG1) belongs to the family of cyclin-dependent protein kinases that were originally characterized as cell cycle regulators in eukaryotes. Here, we report that CDKG1 regulates pre-mRNA splicing of CALLOSE SYNTHASE5 (CalS5) and, therefore, pollen wall formation. The knockout mutant cdkg1 exhibits reduced male fertility with impaired callose synthesis and abnormal pollen wall formation. The sixth intron in CalS5 pre-mRNA, a rare type of intron with a GC 5′ splice site, is abnormally spliced in cdkg1. RNA immunoprecipitation analysis suggests that CDKG1 is associated with this intron. CDKG1 contains N-terminal Ser/Arg (RS) motifs and interacts with splicing factor Arginine/Serine-Rich Zinc Knuckle-Containing Protein33 (RSZ33) through its RS region to regulate proper splicing. CDKG1 and RS-containing Zinc Finger Protein22 (SRZ22), a splicing factor interacting with RSZ33 and U1 small nuclear ribonucleoprotein particle (snRNP) component U1-70k, colocalize in nuclear speckles and reside in the same complex. We propose that CDKG1 is recruited to U1 snRNP through RSZ33 to facilitate the splicing of the sixth intron of CalS5. PMID:23404887

Palaeoenvironmental implications of a Holocene sequence of lacustrine-peat sediments from the desert-loess transitional zone in Northern China

NASA Astrophysics Data System (ADS)

Jia, Feifei; Lu, Ruijie; Liu, Xiaokang; Zhao, Chao; Lv, Zhiqiang; Gao, Shangyu

2018-05-01

A high-resolution lacustrine-peat record from the desert-loess transitional zone in Northern China was obtained to reconstruct Holocene environmental change in the region. AMS 14C dates are used to provide a chronology. The results indicate that the site was a desert environment before 12.2 cal kyr BP, and was then occupied by a paleolake which started to shrink, with a wetland occurring from 6.2 to 3.0 cal kyr BP. Subsequently, the site became a seasonally water-filled depression. Based on the lithology and measurements of grain size and total organic carbon content, the climate changed from arid to humid at 12.2 cal kyr BP, and became more humid after 8.3 cal kyr BP. From 6.2 to 3.0 cal kyr BP, precipitation decreased but the climate remained at an optimum. After 3.0 cal kyr BP, the climate was dry overall but with several humid intervals. A comparison of paleoclimatic records from lacustrine and aeolian deposits from the region reveals a discrepancy about the nature of the early Holocene climate, and we conclude that this is because lacustrine sediments responded more sensitively to precipitation than aeolian deposits when the temperature was low. The environmental evolution of the region was synchronous with changes in the Asian summer monsoon (ASM), but temperature also played a key role in the early Holocene.

Robust colour calibration of an imaging system using a colour space transform and advanced regression modelling.

PubMed

Jackman, Patrick; Sun, Da-Wen; Elmasry, Gamal

2012-08-01

A new algorithm for the conversion of device dependent RGB colour data into device independent L*a*b* colour data without introducing noticeable error has been developed. By combining a linear colour space transform and advanced multiple regression methodologies it was possible to predict L*a*b* colour data with less than 2.2 colour units of error (CIE 1976). By transforming the red, green and blue colour components into new variables that better reflect the structure of the L*a*b* colour space, a low colour calibration error was immediately achieved (ΔE(CAL) = 14.1). Application of a range of regression models on the data further reduced the colour calibration error substantially (multilinear regression ΔE(CAL) = 5.4; response surface ΔE(CAL) = 2.9; PLSR ΔE(CAL) = 2.6; LASSO regression ΔE(CAL) = 2.1). Only the PLSR models deteriorated substantially under cross validation. The algorithm is adaptable and can be easily recalibrated to any working computer vision system. The algorithm was tested on a typical working laboratory computer vision system and delivered only a very marginal loss of colour information ΔE(CAL) = 2.35. Colour features derived on this system were able to safely discriminate between three classes of ham with 100% correct classification whereas colour features measured on a conventional colourimeter were not. Copyright © 2012 Elsevier Ltd. All rights reserved.

Late Holocene monsoon climate as evidenced by proxy records from a lacustrine sediment sequence in western Guangdong, South China

NASA Astrophysics Data System (ADS)

Zhong, Wei; Cao, jiayuan; Xue, Jibin; Ouyang, Jun; Tang, Xiaohong; Yin, Huanling; Liao, Congyun; Long, Kun

2014-02-01

The study of a 300-cm-thick exposed lacustrine sediment section in the Hedong village in Zhaoqing area which is located in sub-tropical west Guangdong Province in South China, demonstrates that the lacustrine sedimentary sequence possibly contains evidence for exploring variation of Asian monsoon climate. Multi-proxy records, including the humification intensity, total organic carbon, and grain size fractions, reveal a general trend towards dry and cold conditions in the late Holocene that this is because of a decrease in solar insolation on an orbital scale. Three intensified Asian summer monsoon (ASM) intervals (˜3300-3000 cal yr BP, ˜2600-1600 cal yr BP, and ˜900-600 cal yr BP), and three weakened ASM intervals (˜4000-3300 cal yr BP, ˜3000-2600 cal yr BP, and ˜1600-900 cal yr BP) are identified. Our humification record (HDcal) shows a good correlation on multi-centennial scale with the tree ring Δ14C record, a proxy of solar activity. A spectral analysis of HDcal reveals four significant cycles, i.e., ˜1250 yr, 300 yr, 110 yr, and 70 yr, and most of these cycles are related to the solar activity. Our findings indicate that solar output and oceanic-atmospheric circulation probably have influenced the late Holocene climate variability in the study region.

Oestrogen directly inhibits the cardiovascular L-type Ca{sup 2+} channel Ca{sub v}1.2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ullrich, Nina D.; Koschak, Alexandra; MacLeod, Kenneth T.

2007-09-21

Oestrogen can modify the contractile function of vascular smooth muscle and cardiomyocytes. The negative inotropic actions of oestrogen on the heart and coronary vasculature appear to be mediated by L-type Ca{sup 2+} channel (Ca{sub v}1.2) inhibition, but the underlying mechanisms remain elusive. We tested the hypothesis that oestrogen directly inhibits the cardiovascular L-type Ca{sup 2+} current, I {sub CaL}. The effect of oestrogen on I {sub CaL} was measured in Ca{sub v}1.2-transfected HEK-293 cells using the whole-cell patch-clamp technique. The current revealed typical activation and inactivation profiles of nifedipine- and cadmium-sensitive I {sub CaL}. Oestrogen (50 {mu}M) rapidly reduced Imore » {sub CaL} by 50% and shifted voltage-dependent activation and availability to more negative potentials. Furthermore, oestrogen blocked the Ca{sup 2+} channel in a rate-dependent way, exhibiting higher efficiency of block at higher stimulation frequencies. Our data suggest that oestrogen inhibits I {sub CaL} through direct interaction of the steroid with the channel protein.« less

Enrolling in Medicaid through the National School Lunch Program: outcome of a pilot project in California schools.

PubMed

Cousineau, Michael R; Wada, Eriko O; Hogan, Laura

2007-01-01

California has several health insurance programs for children. However, the system for enrolling into these programs is complex and difficult to manage for many families. Express Lane Eligibility is designed to streamline the Medicaid (called Medi-Cal in California) enrollment process by linking it to the National School Lunch Program. If a child is eligible for free lunch and the parents consent, the program provides two months of presumptive eligibility for Medi-Cal and a simplified application process for continuation in Medi-Cal. For those who are ineligible, it provides a referral to other programs. An evaluation of Express Lane shows that while many children were presumptively enrolled, nearly half of the applicants were already enrolled in Medi-Cal. Many Express Enrolled children failed to complete the full Medi-Cal enrollment process. Few were referred to the State Children's Health Insurance Program or county programs. Express Lane is less useful as a broad screening strategy, but can be one of many tools that communities use to enroll children in health insurance.

Administrative Assistants' Informal Learning and Related Factors

ERIC Educational Resources Information Center

Cho, Hyun Jung; Kim, Jin-Mo

2016-01-01

Purpose: The purpose of this study is to identify the causal relationship among informal learning, leader-member exchange (LMX), empowerment, job characteristics and job self-efficacy and the impact on administrative assistants in corporations. The study aims at providing information for administrative assistants who have worked with their current…

Curriculum Development of Learning Activity Packets, Dental Assisting Program. Final Report.

ERIC Educational Resources Information Center

Hempler, Nancy A.

A dental assisting instructor was provided with 250 hours of released time to develop standardized Learning Activity Packets (LAPs) for the Dental Assisting program at the Bellingham (Washington) Vocational Technical Institute. The instructor reviewed unit objectives, gathered input from local dental professionals, reviewed reference materials,…

Tale of the Tape: International Teaching Assistant Noticing during Videotaped Classroom Observations

ERIC Educational Resources Information Center

Williams, Gwendolyn M.; Case, Rod E.

2015-01-01

International teaching assistants face challenges in learning the norms for teaching in American universities. In order to address this learning curve this article describes a qualitative study of twenty international teaching assistants that examined how these participants viewed observations as part of their professional development. The study…

On the Conditioning of Machine-Learning-Assisted Turbulence Modeling

NASA Astrophysics Data System (ADS)

Wu, Jinlong; Sun, Rui; Wang, Qiqi; Xiao, Heng

2017-11-01

Recently, several researchers have demonstrated that machine learning techniques can be used to improve the RANS modeled Reynolds stress by training on available database of high fidelity simulations. However, obtaining improved mean velocity field remains an unsolved challenge, restricting the predictive capability of current machine-learning-assisted turbulence modeling approaches. In this work we define a condition number to evaluate the model conditioning of data-driven turbulence modeling approaches, and propose a stability-oriented machine learning framework to model Reynolds stress. Two canonical flows, the flow in a square duct and the flow over periodic hills, are investigated to demonstrate the predictive capability of the proposed framework. The satisfactory prediction performance of mean velocity field for both flows demonstrates the predictive capability of the proposed framework for machine-learning-assisted turbulence modeling. With showing the capability of improving the prediction of mean flow field, the proposed stability-oriented machine learning framework bridges the gap between the existing machine-learning-assisted turbulence modeling approaches and the demand of predictive capability of turbulence models in real applications.

Bladder Cancer Segmentation in CT for Treatment Response Assessment: Application of Deep-Learning Convolution Neural Network-A Pilot Study.

PubMed

Cha, Kenny H; Hadjiiski, Lubomir M; Samala, Ravi K; Chan, Heang-Ping; Cohan, Richard H; Caoili, Elaine M; Paramagul, Chintana; Alva, Ajjai; Weizer, Alon Z

2016-12-01

Assessing the response of bladder cancer to neoadjuvant chemotherapy is crucial for reducing morbidity and increasing quality of life of patients. Changes in tumor volume during treatment is generally used to predict treatment outcome. We are developing a method for bladder cancer segmentation in CT using a pilot data set of 62 cases. 65 000 regions of interests were extracted from pre-treatment CT images to train a deep-learning convolution neural network (DL-CNN) for tumor boundary detection using leave-one-case-out cross-validation. The results were compared to our previous AI-CALS method. For all lesions in the data set, the longest diameter and its perpendicular were measured by two radiologists, and 3D manual segmentation was obtained from one radiologist. The World Health Organization (WHO) criteria and the Response Evaluation Criteria In Solid Tumors (RECIST) were calculated, and the prediction accuracy of complete response to chemotherapy was estimated by the area under the receiver operating characteristic curve (AUC). The AUCs were 0.73 ± 0.06, 0.70 ± 0.07, and 0.70 ± 0.06, respectively, for the volume change calculated using DL-CNN segmentation, the AI-CALS and the manual contours. The differences did not achieve statistical significance. The AUCs using the WHO criteria were 0.63 ± 0.07 and 0.61 ± 0.06, while the AUCs using RECIST were 0.65 ± 007 and 0.63 ± 0.06 for the two radiologists, respectively. Our results indicate that DL-CNN can produce accurate bladder cancer segmentation for calculation of tumor size change in response to treatment. The volume change performed better than the estimations from the WHO criteria and RECIST for the prediction of complete response.

Bladder Cancer Segmentation in CT for Treatment Response Assessment: Application of Deep-Learning Convolution Neural Network—A Pilot Study

PubMed Central

Cha, Kenny H.; Hadjiiski, Lubomir M.; Samala, Ravi K.; Chan, Heang-Ping; Cohan, Richard H.; Caoili, Elaine M.; Paramagul, Chintana; Alva, Ajjai; Weizer, Alon Z.

2017-01-01

Assessing the response of bladder cancer to neoadjuvant chemotherapy is crucial for reducing morbidity and increasing quality of life of patients. Changes in tumor volume during treatment is generally used to predict treatment outcome. We are developing a method for bladder cancer segmentation in CT using a pilot data set of 62 cases. 65 000 regions of interests were extracted from pre-treatment CT images to train a deep-learning convolution neural network (DL-CNN) for tumor boundary detection using leave-one-case-out cross-validation. The results were compared to our previous AI-CALS method. For all lesions in the data set, the longest diameter and its perpendicular were measured by two radiologists, and 3D manual segmentation was obtained from one radiologist. The World Health Organization (WHO) criteria and the Response Evaluation Criteria In Solid Tumors (RECIST) were calculated, and the prediction accuracy of complete response to chemotherapy was estimated by the area under the receiver operating characteristic curve (AUC). The AUCs were 0.73 ± 0.06, 0.70 ± 0.07, and 0.70 ± 0.06, respectively, for the volume change calculated using DL-CNN segmentation, the AI-CALS and the manual contours. The differences did not achieve statistical significance. The AUCs using the WHO criteria were 0.63 ± 0.07 and 0.61 ± 0.06, while the AUCs using RECIST were 0.65 ± 007 and 0.63 ± 0.06 for the two radiologists, respectively. Our results indicate that DL-CNN can produce accurate bladder cancer segmentation for calculation of tumor size change in response to treatment. The volume change performed better than the estimations from the WHO criteria and RECIST for the prediction of complete response. PMID:28105470

Navigation assistance: a trade-off between wayfinding support and configural learning support.

PubMed

Münzer, Stefan; Zimmer, Hubert D; Baus, Jörg

2012-03-01

Current GPS-based mobile navigation assistance systems support wayfinding, but they do not support learning about the spatial configuration of an environment. The present study examined effects of visual presentation modes for navigation assistance on wayfinding accuracy, route learning, and configural learning. Participants (high-school students) visited a university campus for the first time and took a predefined assisted tour. In Experiment 1 (n = 84, 42 females), a presentation mode showing wayfinding information from eye-level was contrasted with presentation modes showing wayfinding information included in views that provided comprehensive configural information. In Experiment 2 (n = 48, 24 females), wayfinding information was included in map fragments. A presentation mode which always showed north on top of the device was compared with a mode which rotated according to the orientation of the user. Wayfinding accuracy (deviations from the route), route learning, and configural learning (direction estimates, sketch maps) were assessed. Results indicated a trade-off between wayfinding and configural learning: Presentation modes providing comprehensive configural information supported the acquisition of configural knowledge at the cost of accurate wayfinding. The route presentation mode supported wayfinding at the cost of configural knowledge acquisition. Both presentation modes based on map fragments supported wayfinding. Individual differences in visual-spatial working memory capacity explained a considerable portion of the variance in wayfinding accuracy, route learning, and configural learning. It is concluded that learning about an unknown environment during assisted navigation is based on the integration of spatial information from multiple sources and can be supported by appropriate visualization. PsycINFO Database Record (c) 2012 APA, all rights reserved.

The use of a mobile assistant learning system for health education based on project-based learning.

PubMed

Wu, Ting-Ting

2014-10-01

With the development of mobile devices and wireless technology, mobile technology has gradually infiltrated nursing practice courses to facilitate instruction. Mobile devices save manpower and reduce errors while enhancing nursing students' professional knowledge and skills. To achieve teaching objectives and address the drawbacks of traditional education, this study presents a mobile assistant learning system to help nursing students prepare health education materials. The proposed system is based on a project-based learning strategy to assist nursing students with internalizing professional knowledge and developing critical thinking skills. Experimental results show that the proposed mobile system and project-based learning strategy can promote learning effectiveness and efficiency. Most nursing students and nursing educators showed positive attitudes toward this mobile learning system and looked forward to using it again in related courses in the future.

Computer-Assisted Foreign Language Teaching and Learning: Technological Advances

ERIC Educational Resources Information Center

Zou, Bin; Xing, Minjie; Wang, Yuping; Sun, Mingyu; Xiang, Catherine H.

2013-01-01

Computer-Assisted Foreign Language Teaching and Learning: Technological Advances highlights new research and an original framework that brings together foreign language teaching, experiments and testing practices that utilize the most recent and widely used e-learning resources. This comprehensive collection of research will offer linguistic…

Adaptive Web-Assisted Learning System for Students with Specific Learning Disabilities: A Needs Analysis Study

ERIC Educational Resources Information Center

Polat, Elif; Adiguzel, Tufan; Akgun, Ozcan Erkan

2012-01-01

Because there is, currently, no education system for primary school students in grades 1-3 who have specific learning disabilities in Turkey and because such students do not receive sufficient support from face-to-face counseling, a needs analysis was conducted in order to prepare an adaptive, web-assisted learning system according to variables…

Mobile Assisted Language Learning in University EFL Courses in Japan: Developing Attitudes and Skills for Self-Regulated Learning

ERIC Educational Resources Information Center

Kondo, Mutsumi; Ishikawa, Yasushige; Smith, Craig; Sakamoto, Kishio; Shimomura, Hidenori; Wada, Norihisa

2012-01-01

This paper reports a project in which researchers at universities in Japan explored the use of Mobile Assisted Language Learning (MALL) practices by developing a learning module intended to help improve students' scores on the TOEIC Listening and Reading Tests. MALL practices are currently being developed at universities in Japan because almost…

Use of Personal Digital Assistants (PDAs) in Reflection on Learning and Practice

ERIC Educational Resources Information Center

Ranson, Sonya L.; Boothby, John; Mazmanian, Paul E.; Alvanzo, Anika

2007-01-01

Introduction: As the use of personal digital assistants (PDAs) grows, the value of reflection of learning and practice draws increased attention from policymakers and evaluators. To learn more about the use of PDAs in practice and learning, the present study describes use of (1) PDAs in patient care and (2) a PDA version of the Virginia Board of…

Connecting in Rhizomic Spaces: Peer-Assisted Learning (PAL) and E-Learning in Teacher Education

ERIC Educational Resources Information Center

Bone, Jane; Edwards, Susan

2015-01-01

A PAL (Peer-Assisted Learning) project supported research that focused on e-learning and Web 2.0 technologies as part of a pedagogical approach in the context of a tertiary institution. This project responded to a call for a rejuvenation of conventional approaches to pedagogy while teaching an early childhood unit in a large Australian university.…

Is Mobile-Assisted Language Learning Really Useful? An Examination of Recall Automatization and Learner Autonomy

ERIC Educational Resources Information Center

Sato, Takeshi; Murase, Fumiko; Burden, Tyler

2015-01-01

The aim of this study is to examine the advantages of Mobile-Assisted Language Learning (MALL), especially vocabulary learning of English as a foreign or second language (L2) in terms of the two strands: automatization and learner autonomy. Previous studies articulate that technology-enhanced L2 learning could bring about some positive effects.…

Engineering Test Report Paint Waste Reduction Fluidized Bed Process Demonstration at Letterkenny Army Depot Chambersburg, Pennsylvania

DTIC Science & Technology

1991-07-01

predicted by equation using actual chart response obtained from each calibration gas response. (Concentration of cal. gas,l Calibration error, % span • ppm...Analyzer predicted by cali- Col. gas Chart divisions equation* bration Cylinder conc., error,** Drift,***INo. ppm or % Pretest Posttest Pretest Posttest...2m ~J * Correlation coef. * qgq’jq **Analyzer ca.error, % spn (Cal. gas conc. conc. predicted ) x 1003 cal spanSpan value Acceptable limit x ɚ% of

The X-ray eclipse of the LMC binary CAL 87

NASA Technical Reports Server (NTRS)

Schmidtke, P. C.; Mcgrath, T. K.; Cowley, A. P.; Frattare, L. M.

1993-01-01

ROSAT-PSPC observations of the LMC eclipsing binary CAL 87 show a short-duration, shallow X-ray eclipse which coincides in phase with the primary optical minimum. Characteristics of the eclipse suggest the X-ray emitting region is only partially occulted. Similarities with the eclipse of the accretion-disk corona in X 1822-37 are discussed. However, no temperature variation through eclipse is found for CAL 87. A revised orbital period, combining published data and recent optical photometry, is given.

Modeling and Simulation of Ceramic Arrays to Improve Ballaistic Performance

DTIC Science & Technology

2013-09-09

targets with .30cal AP M2 projectile using SPH elements. -Model validation runs were conducted based on the DoP experiments described in reference...effect of material properties on DoP 15. SUBJECT TERMS .30cal AP M2 Projectile, 762x39 PS Projectile, SPH , Aluminum 5083, SiC, DoP Expeminets...and ceramic-faced aluminum targets with „30cal AP M2 projectile using SPH elements. □ Model validation runs were conducted based on the DoP

Physical assistance devices in complex motor skill learning: benefits of a self-controlled practice schedule.

PubMed

Wulf, G; Toole, T

1999-09-01

This study examines the effects of a self-controlled use of physical assistance devices on learning a complex motor skill (i.e., producing slalom-type movements on a ski simulator). Physical assistance was provided by ski poles. One group of learners (self-control) was provided with the poles whenever they requested them, whereas another (yoked) group had no influence on the pole/no-pole schedule. While there were no group differences during the practice phase (Days 1 and 2), clear group differences emerged in the retention test without poles (Day 3). The self-control group produced significantly larger amplitudes than the yoked group. These results extend previous findings by showing learning advantages of the self-controlled use of physical assistance devices in complex motor skill learning.

EpiAssist: Service-learning in public health education.

PubMed

Horney, Jennifer A; Bamrara, Sanjana; Macik, Maria Lazo; Shehane, Melissa

2016-01-01

Although public health degree programs typically require practica and other field experiences, service-learning courses, with a focus on civic engagement and the application of classroom learning in real world settings, can go beyond these requirements and provide benefits to students and community-based practice partners. The goal of this paper is to assess potential benefits of service-learning programs for both graduate-level public health students and state and local public health agency partners. EpiAssist is a new service-learning program developed at the School of Public Health of the Texas A and M University Health Science Center, USA, in January 2015. EpiAssist was integrated into a new course, Methods in Field Epidemiology. The integration of service-learning was guided by a partnership with the Texas A and M Center for Teaching Excellence. State, regional, and local public health partners requested EpiAssist via email or telephone. A listserv was used to recruit student volunteers to meet requests. 54 of 86 registered EpiAssist students (63%) participated in at least one of ten service-learning and three training activities between January and June, 2015. Service-learning activities included questionnaire development, in-person and telephone data collection, and data analysis. Training topics for students included the Epi Info™ software, community assessment and communicable disease reporting. Students and partner organizations provided generally positive assessments of this service learning program through an online evaluation. Service-learning provides students with enhanced classroom learning through applied public health experience in state, regional and local health departments. These experiences provide both needed surge capacity to public health departments and valuable hands-on field experience to students.

High-resolution climate of the past ∼7300 years of coastal northernmost California: Results from diatoms, silicoflagellates, and pollen

USGS Publications Warehouse

Barron, John A.; Bukry, David; Heusser, Linda E.; Addison, Jason A.; Alexander, Clark R.

2018-01-01

Piston core TN062-O550, collected about 33 km offshore of Eureka, California, contains a high-resolution record of the climate and oceanography of coastal northernmost California during the past ∼7.34 kyr. Chronology established by nine AMS ages on a combination of planktic foraminifers, bivalve shell fragments, and wood yields a mean sedimentation rate of 103 cm kyr−1. Marine proxies (diatoms and silicoflagellates) and pollen transported by the nearby Eel River reveal a stepwise development of both modern offshore surface water oceanography and coastal arboreal ecosystems. Beginning at ∼5.4 cal ka the relative abundance of coastal redwood pollen, a proxy for coastal fog, displays a two fold increase suggesting enhanced coastal upwelling. A decline in the relative contribution of subtropical diatoms at ∼5.0 cal ka implies cooling of sea surface temperatures (SSTs). At ∼3.6 cal ka an increase in the relative abundance of alder and oak at the expense of coastal redwood likely signals intensified riverine transport of pollen from inland environments. Cooler offshore SSTs and increased precipitation characterize the interval between ∼3.6 and 2.8 cal ka. A rapid, stepwise change in coastal climatology and oceanography occurs between ∼2.8 and 2.6 cal ka that suggests an enhanced expression of modern Pacific Decadal Oscillation-like (PDO) cycles. A three-fold increase in the relative abundance of the subtropical diatom Fragilariopsis doliolus at 2.8 cal ka appears to mark an abrupt warming of winter SSTs. Soon afterwards at 2.6 cal ka, a two fold increase in the relative abundance of coastal redwood pollen is suggestive of an abrupt intensification of spring upwelling. After ∼2.8 cal ka a sequence of cool-warm, PDO-like cycles occurs wherein cool cycles are characterized by relative abundance increases in coastal redwood pollen and decreased contributions of subtropical diatoms, whereas opposite proxy trends distinguish warm cycles.

Late Pleistocene to Holocene lake levels of Lake Warner, Oregon (USA) and their effect on archaeological site distribution patterns

NASA Astrophysics Data System (ADS)

Wriston, T.; Smith, G. M.

2017-12-01

Few chronological controls are available for the rise and fall of small pluvial lake systems in the Northwestern Great Basin. Within Warner Basin this control was necessary for interpretation of known archaeological sites and for predicting where evidence of its earliest inhabitants might be expected. We trenched along relic beach ridges of Lake Warner, surveyed a stratified sample of the area for archaeological sites, and excavated some sites and a nearby rockshelter. These efforts produced new ages that we used to construct a lake level curve for Lake Warner. We found that the lake filled the valley floor between ca. 30,000 cal yr BP and ca. 10,300 cal yr BP. In nearby basins, several oscillations are evident before ca. 21,100 cal yr BP, but a steep rise to the LGM maximum occurred between 21,000 and 20,000 cal yr BP. Lake Warner likely mirrored these changes, dropped to the valley floor ca. 18,340 cal yr BP, and then rose to its maximum highstand when its waters briefly reached 1454 m asl. After this highstand the lake receded to moderately high levels. Following ca. 14,385 cal yr BP, the lake oscillated between moderate to moderately-high levels through the Bolling-Allerod interstadials and into the Younger Dryas stadial. The basin's first occupants arrived along its shore around this time, while the lake still filled the valley floor. These earliest people carried either Western Stemmed or Clovis projectile points, both of which are found along the lake margin. The lake receded into the valley floor ca. 10,300 cal yr BP and dune development began, ringing wetlands and small lakes that persisted in the footprint of the once large lake. By the time Mazama tephra fell 7,600 cal yr BP it blanketed pre-existing dunes and marsh peats. Our Lake Warner lake level curve facilitates interdisciplinary testing and refinement of it and similar curves throughout the region while helping us understand the history of lake and the people who lived along its shores.

Risk factors of chronic periodontitis on healing response: a multilevel modelling analysis.

PubMed

Song, J; Zhao, H; Pan, C; Li, C; Liu, J; Pan, Y

2017-09-15

Chronic periodontitis is a multifactorial polygenetic disease with an increasing number of associated factors that have been identified over recent decades. Longitudinal epidemiologic studies have demonstrated that the risk factors were related to the progression of the disease. A traditional multivariate regression model was used to find risk factors associated with chronic periodontitis. However, the approach requirement of standard statistical procedures demands individual independence. Multilevel modelling (MLM) data analysis has widely been used in recent years, regarding thorough hierarchical structuring of the data, decomposing the error terms into different levels, and providing a new analytic method and framework for solving this problem. The purpose of our study is to investigate the relationship of clinical periodontal index and the risk factors in chronic periodontitis through MLM analysis and to identify high-risk individuals in the clinical setting. Fifty-four patients with moderate to severe periodontitis were included. They were treated by means of non-surgical periodontal therapy, and then made follow-up visits regularly at 3, 6, and 12 months after therapy. Each patient answered a questionnaire survey and underwent measurement of clinical periodontal parameters. Compared with baseline, probing depth (PD) and clinical attachment loss (CAL) improved significantly after non-surgical periodontal therapy with regular follow-up visits at 3, 6, and 12 months after therapy. The null model and variance component models with no independent variables included were initially obtained to investigate the variance of the PD and CAL reductions across all three levels, and they showed a statistically significant difference (P < 0.001), thus establishing that MLM data analysis was necessary. Site-level had effects on PD and CAL reduction; those variables could explain 77-78% of PD reduction and 70-80% of CAL reduction at 3, 6, and 12 months. Other levels only explain 20-30% of PD and CAL reductions. Site-level had the greatest effect on PD and CAL reduction. Non-surgical periodontal therapy with regular follow-up visits had a remarkable curative effect. All three levels had a substantial influence on the reduction of PD and CAL. Site-level had the largest effect on PD and CAL reductions.

Holocene Summer Monsoon Variability- Evidence from Marine Sediment of western Continental Shelf of Sri Lanka

NASA Astrophysics Data System (ADS)

Ranasinghage, P. N.; Ratnayake, K. M.; Dassanayake, D. M. K. K.; Mohtadi, M.; Hewawasam, T.; Jinadasa, S. U. P.; Jayawardena, S.; Siriwardana, S.

2016-12-01

Understanding long term variability of Indian monsoon system is essential for better climate forecasting which is a prerequisite for agricultural development and disaster management. Yet, it has been a least attended scientific question in Sri Lanka Therefore, this study was carried out to understand the monsoonal variability during the Holocene using multiple proxies on a sediment core, representing unmixed summer monsoonal record. A 390 cm long piston core was obtained from the continental shelf off Negombo by National Aquatic Resources Research and Development Agency , was used for this study. This site mainly receives sediment from rivers fed by summer monsoon. Colour reflectance and chemical composition of the sediments, and δ18O and δ13C of Globigerinoides ruber foraminifera, extracted from the sediments were measured at 0.1-2.0 cm resolutions. Principal component analysis of chemical compositional data and colour reflectance data was performed to extract important components that represent climate variability. Benthic and planktonic foraminifera species that indicate upwelling were counted at 2 cm resolution. Radiocarbon dating was carried out using intact micro-shells. Results indicate that upwelling proxies (δ13C, foraminiferal proxies, and colour reflectance-Chlorophyll) and δ18O, which indicates evaporation-precipitation (E-P), increased during 8000-10000 cal yrs BP, 2000-4000 cal yrs BP and again after 1000 cal yrs BP. This increase in upwelling and E-P indicates strengthening of summer monsoon during these periods. However, terrestrial proxies, (XRF-PC1-Terrestrial, Ti, and DSR-PC3-iron oxides)indicate decrease in terrestrial influx which represents rainfall, from 6000-1000 cal yrs BP followed by an increase after 1000 cal yrs BP. Gradual decrease in precipitation has been observed locally as well as regionally after around 6000 cal yrs BP followed by an increase after 1000 cal yrs BP. The contrast behavior of strengthening monsoonal winds and decreasing precipitation during 2000-4000 cal yrs BP has also been observed in Arabian Sea close to the west coast of India. Although monsoonal wind strength is increased, change in its direction, which decreases orographic effect, or weakening of convergence in the vicinity of Sri Lanka, could be possible reasons for this phenomenon.

Holocene water mass history off NE Greenland - A first high-resolution sediment record from the western Fram Strait

NASA Astrophysics Data System (ADS)

Zehnich, Marc; Palme, Tina; Spielhagen, Robert F.; Hass, H. Christian; Bauch, Henning A.

2017-04-01

While the Holocene history of the eastern Fram Strait seems well investigated, no high-resolution paleoenvironmental records were available from the western Fram Strait so far. A new sedimentary record, obtained during expedition PS93.1 (2015) of RV Polarstern on the outermost NE Greenland shelf, allows for the first time to reconstruct Holocene changes in near-surface salinities, temperature, stratification and water masses (polar waters vs. Atlantic Water), potentially related to variations of the freshwater and sea ice export from the Arctic Ocean. The 260 cm long sedimentary record from site PS93/025 (80.5°N, 8.5°W) was investigated for sediment composition, foraminifer contents, grain size variations (sortable silt) and the isotopic composition of planktic foraminifers. Radiocarbon datings reveal an age of 10.2 cal-ka for the core base and continuous sedimentation throughout most of the Holocene. The sediments are generally very fine-grained (<2% sand). The grain size record reveals a fining-upwards trend and sediments from <6.5 cal-ka consist of <0.5% coarse fraction. A comparison of foraminifer and coarse fraction abundances shows strong similarities. Apparently the contribution of coarse terrestrial material from iceberg transport was extremely low throughout the last 10.2 cal-ka. Foraminifer abundances (both planktic and benthic) are high in Early Holocene sediments until ca. 7 cal-ka and decrease rapidly thereafter. This is interpreted to reflect a relatively strong advection of Atlantic Water to the NW Fram Strait, which correlates well with similar findings on the eastern side of the Arctic Gateway. Sortable silt grain sizes are high (27-32 µm) in the older part of the record and gradually decrease between 7 cal-ka and 4 cal-ka. After ca. 4 cal-ka, sortable silt shows values of 20-22 µm and little variation. Considering also the grain-size distribution curves, we propose a decline of bottom current velocities on the outer NE Greenland shelf after 7 cal-ka, related to a decrease of Atlantic Water advection. These preliminary results reveal a strong coupling of Holocene environments on both sides of the Fram Strait.

Cal-Bridge and CAMPARE: Engaging Underrepresented Students in Physics and Astronomy

NASA Astrophysics Data System (ADS)

Rudolph, Alexander L.; Smecker-Hane, Tammy A.; Cal-Bridge Team; CAMPARE Team

2018-06-01

We describe two programs, Cal-Bridge and CAMPARE, with the common mission of increasing participation of groups traditionally underrepresented in astronomy, through summer research opportunities, in the case of CAMPARE, scholarships in the case of Cal-Bridge, and significant mentoring in both programs, creating a national impact on their numbers successfully pursuing a PhD in the field. In 9 years, the CAMPARE program has sent 150 students, >80% from underrepresented groups, to conduct summer research at one of 14 major research institutions throughout the country. Of the CAMPARE scholars who have graduated with a Bachelor’s degree, almost two-thirds (65%) have completed or are pursuing graduate education in physics, astronomy, or a related field, at institutions including UCLA, UC Riverside, UC Irvine, UC Santa Barbara, USC, Stanford, Univ. of Arizona, Univ. of Washington, Univ. of Rochester, Michigan State Univ., Georgia Tech, Georgia State Univ., Kent State, Indiana Univ., Univ. of Oregon, Syracuse Univ., Montana State Univ., and the Fisk- Vanderbilt Master’s-to-PhD program. Now in its fourth year, the Cal-Bridge program is a CSU-UC Bridge program comprised of physics and astronomy faculty from 9 University of California (UC), 15 California State University (CSU), and more than 30 California Community College (CCC) campuses throughout California. In the first four years, 34 Cal-Bridge Scholars have been selected, including 22 Hispanic, 3 African-American and 13 women students, 10 of whom are from URM groups. Thirty (30) of the 34 Cal-Bridge Scholars are first generation college students. In the last three years, 17 of 21 Cal-Bridge Scholars have begun or been accepted PhD programs in physics or astronomy at top PhD programs nationally. Three (3) of these scholars have won NSF Graduate Research Fellowships; one more received an Honorable Mention. Once selected, Cal-Bridge Scholars benefit from substantial financial support, intensive, joint mentoring by CSU and UC faculty, professional development workshops, and exposure to research opportunities at the participating UC campuses. Funding for this program is provided by NSF-DUE SSTEM Grant #1356133.

The Late-Glacial and Holocene Marboré Lake sequence (2612 m a.s.l., Central Pyrenees, Spain): Testing high altitude sites sensitivity to millennial scale vegetation and climate variability

NASA Astrophysics Data System (ADS)

Leunda, Maria; González-Sampériz, Penélope; Gil-Romera, Graciela; Aranbarri, Josu; Moreno, Ana; Oliva-Urcia, Belén; Sevilla-Callejo, Miguel; Valero-Garcés, Blas

2017-10-01

This paper presents the environmental, climate and vegetation changes reconstructed for the last 14.6 kyr cal BP from the Marboré Lake sedimentary sequence, the highest altitude record (2612 m a.s.l.) in the Pyrenees studied up to date. We investigate the sensitivity of this high altitude site to vegetational and climate dynamics and altitudinal shifts during the Holocene by comparing palynological spectra of the fossil sequence and pollen rain content from current moss pollsters. We hypothesize that the input of sediments in lakes at such altitude is strongly controlled by ice phenology (ice-free summer months) and that during cold periods Pollen Accumulation Rate (PAR) and Pollen Concentration (PC) reflect changes in ice-cover and thus is linked to temperature changes. Low sedimentation rates and low PC and PAR occurred during colder periods as the Younger Dryas (GS-1) and the Holocene onset (12.6-10.2 kyr cal BP), suggesting that the lake-surface remained ice-covered for most of the year during these periods. Warmer conditions are not evident until 10.2 kyr cal BP, when an abrupt increase in sedimentation rate, PC and PAR occur, pointing to a delayed onset of the Holocene temperature increase at high altitude. Well-developed pinewoods and deciduous forest dominated the mid montane belt since 9.3 kyr cal BP until mid-Holocene (5.2 kyr cal BP). A downwards shift in the deciduous forest occurred after 5.2 kyr cal BP, in agreement with the aridity trend observed at a regional and Mediterranean context. The increase of herbaceous taxa during the late-Holocene (3.5 kyr cal BP-present) reflects a general trend to reduced montane forest, as anthropogenic disturbances were not evident until 1.3 kyr cal BP when Olea proportions from lowland areas and other anthropogenic indicators clearly expand. Our study demonstrates the need to perform local experimental approaches to check the effect of ice phenology on high altitude lakes sensitivity to vegetation changes to obtain more realistic reconstructions of mountain vegetation belts dynamics.

The LEONARDO-DA-VINCI pilot project "e-learning-assistant" - Situation-based learning in nursing education.

PubMed

Pfefferle, Petra Ina; Van den Stock, Etienne; Nauerth, Annette

2010-07-01

E-learning will play an important role in the training portfolio of students in higher and vocational education. Within the LEONARDO-DA-VINCI action programme transnational pilot projects were funded by the European Union, which aimed to improve the usage and quality of e-learning tools in education and professional training. The overall aim of the LEONARDO-DA-VINCI pilot project "e-learning-assistant" was to create new didactical and technical e-learning tools for Europe-wide use in nursing education. Based on a new situation-oriented learning approach, nursing teachers enrolled in the project were instructed to adapt, develop and implement e- and blended learning units. According to the training contents nursing modules were developed by teachers from partner institutions, implemented in the project centers and evaluated by students. The user-package "e-learning-assistant" as a product of the project includes two teacher training units, the authoring tool "synapse" to create situation-based e-learning units, a student's learning platform containing blended learning modules in nursing and an open sourced web-based communication centre. Copyright 2009 Elsevier Ltd. All rights reserved.

Optimizing Computer Assisted Instruction By Applying Principles of Learning Theory.

ERIC Educational Resources Information Center

Edwards, Thomas O.

The development of learning theory and its application to computer-assisted instruction (CAI) are described. Among the early theoretical constructs thought to be important are E. L. Thorndike's concept of learning connectisms, Neal Miller's theory of motivation, and B. F. Skinner's theory of operant conditioning. Early devices incorporating those…

Mathematical Modeling and Computational Thinking

ERIC Educational Resources Information Center

Sanford, John F.; Naidu, Jaideep T.

2017-01-01

The paper argues that mathematical modeling is the essence of computational thinking. Learning a computer language is a valuable assistance in learning logical thinking but of less assistance when learning problem-solving skills. The paper is third in a series and presents some examples of mathematical modeling using spreadsheets at an advanced…

Teacher Perspectives on the Integration of Mobile-Assisted Language Learning

ERIC Educational Resources Information Center

Grimshaw, Jennica; Cardoso, Walcir; Collins, Laura

2017-01-01

Mobile-Assisted Language Learning (MALL) provides second language (L2) learners and teachers with resources to enhance the learning experience, including its anytime, anywhere accessibility (Traxler, 2007). However, factors such as lack of confidence with technology (Son, 2014) and time limitations (Godwin-Jones, 2015) may prevent teachers from…

Graduate Teaching Assistants in the Learning Paradigm: Beliefs about Inclusive Teaching

ERIC Educational Resources Information Center

Embry, Priscilla B.; McGuire, Joan M.

2011-01-01

The learning paradigm emphasizes teaching in ways that facilitate learning for all students. As novice instructors of an increasingly diverse student population, graduate teaching assistants (GTAs) frequently have full responsibility for teaching undergraduate courses. This study investigated GTAs' beliefs about including diverse learners in their…

"Periscope": Looking into Learning in Best-Practices Physics Classrooms

ERIC Educational Resources Information Center

Scherr, Rachel E.; Goertzen, Renee Michelle

2018-01-01

"Periscope" is a set of lessons to support learning assistants, teaching assistants, and faculty in learning to notice and interpret classroom events the way an accomplished teacher does. "Periscope" lessons are centered on video episodes from a variety of best-practices university physics classrooms. By observing, discussing,…

Using Games to Creatively Enhance the Counselor Education Curriculum

ERIC Educational Resources Information Center

Swank, Jacqueline M.

2012-01-01

Utilizing games within the classroom may assist counselor educators with enhancing learning. Counselor educators may integrate games within the curriculum to assist students in learning and developing self-awareness and to assess knowledge and skills. This article describes the utilization of games within experiential-learning theory and presents…

Assist-as-needed robotic trainer based on reinforcement learning and its application to dart-throwing.

PubMed

Obayashi, Chihiro; Tamei, Tomoya; Shibata, Tomohiro

2014-05-01

This paper proposes a novel robotic trainer for motor skill learning. It is user-adaptive inspired by the assist-as-needed principle well known in the field of physical therapy. Most previous studies in the field of the robotic assistance of motor skill learning have used predetermined desired trajectories, and it has not been examined intensively whether these trajectories were optimal for each user. Furthermore, the guidance hypothesis states that humans tend to rely too much on external assistive feedback, resulting in interference with the internal feedback necessary for motor skill learning. A few studies have proposed a system that adjusts its assistive strength according to the user's performance in order to prevent the user from relying too much on the robotic assistance. There are, however, problems in these studies, in that a physical model of the user's motor system is required, which is inherently difficult to construct. In this paper, we propose a framework for a robotic trainer that is user-adaptive and that neither requires a specific desired trajectory nor a physical model of the user's motor system, and we achieve this using model-free reinforcement learning. We chose dart-throwing as an example motor-learning task as it is one of the simplest throwing tasks, and its performance can easily be and quantitatively measured. Training experiments with novices, aiming at maximizing the score with the darts and minimizing the physical robotic assistance, demonstrate the feasibility and plausibility of the proposed framework. Copyright © 2014 Elsevier Ltd. All rights reserved.

Effectiveness of multimedia-supported education in practical sports courses.

PubMed

Leser, Roland; Baca, Arnold; Uhlig, Johannes

2011-01-01

Multimedia-assisted teaching and learning have become standard forms of education. In sports, multimedia material has been used to teach practical aspects of courses, such as motor skills. The main goal of this study is to examine if multimedia technology impacts learning in the field of sport motor skill acquisition. This question was investigated during a practical sports education course involving 35 students who participated in a university soccer class. The whole course was split into two groups: Group A was taught traditionally with no assistance of multimedia and Group B was prepared with multimedia-assisted instructional units. To quantify selected skills of soccer technique and tactic, the test subjects performed a specific passing test and a tactical assessment. Furthermore, a ques-tionnaire was used to assess the subjective impressions of the test subjects. All testing instruments were applied before and after a six-week-long teaching period. A comparison of the gathered data between the two groups resulted in no significant differences, neither concerning the results of the technique test nor concerning the tactic test. However, the results of the ques-tionnaire showed a positive agreement among the participants in the usability and assistance of multimedia for the sports practical course. Considering the reviewed conditions, it can be concluded that the use of multimedia content doesn't affect the learning effects. Key pointsMultimedia-assisted learning showed no positive learning effects on technical skills in soccer.Multimedia-assisted learning showed no positive learning effects on tactical skills in soccer.Students participating in practical sports courses have very good attitudes towards the use of multi-media learning material. This may be considered for motivational effects.

Effectiveness of Multimedia-Supported Education in Practical Sports Courses

PubMed Central

Leser, Roland; Baca, Arnold; Uhlig, Johannes

2011-01-01

Multimedia-assisted teaching and learning have become standard forms of education. In sports, multimedia material has been used to teach practical aspects of courses, such as motor skills. The main goal of this study is to examine if multimedia technology impacts learning in the field of sport motor skill acquisition. This question was investigated during a practical sports education course involving 35 students who participated in a university soccer class. The whole course was split into two groups: Group A was taught traditionally with no assistance of multimedia and Group B was prepared with multimedia-assisted instructional units. To quantify selected skills of soccer technique and tactic, the test subjects performed a specific passing test and a tactical assessment. Furthermore, a ques-tionnaire was used to assess the subjective impressions of the test subjects. All testing instruments were applied before and after a six-week-long teaching period. A comparison of the gathered data between the two groups resulted in no significant differences, neither concerning the results of the technique test nor concerning the tactic test. However, the results of the ques-tionnaire showed a positive agreement among the participants in the usability and assistance of multimedia for the sports practical course. Considering the reviewed conditions, it can be concluded that the use of multimedia content doesn’t affect the learning effects. Key points Multimedia-assisted learning showed no positive learning effects on technical skills in soccer. Multimedia-assisted learning showed no positive learning effects on tactical skills in soccer. Students participating in practical sports courses have very good attitudes towards the use of multi-media learning material. This may be considered for motivational effects. PMID:24149313

Providing Adequate Interactions in Online Discussion Forums Using Few Teaching Assistants

ERIC Educational Resources Information Center

Chang, Chih-Kai; Chen, Gwo-Dong; Hsu, Ching-Kun

2011-01-01

In order to encourage students to participate in online learning forums, prompt responses to their questions are essential. To answer students' online questions, teaching assistants are assigned to manage discussions and answer questions in online learning forums. To minimize the response time, many teaching assistants may be needed to interact…

Peer-Assisted Tutoring in a Chemical Engineering Curriculum: Tutee and Tutor Experiences

ERIC Educational Resources Information Center

Kieran, Patricia; O'Neill, Geraldine

2009-01-01

Peer-Assisted Tutorials (PATs), a form of Peer-Assisted Learning (PAL), were introduced to a conventional 4-year honours degree programme in Chemical Engineering. PATs were designed to support students in becoming more self-directed in their learning, to develop student confidence in tackling Chemical Engineering problems and to promote effective…

Mobile Learning as Alternative to Assistive Technology Devices for Special Needs Students

ERIC Educational Resources Information Center

Ismaili, Jalal; Ibrahimi, El Houcine Ouazzani

2017-01-01

Assistive Technology (AT) revolutionized the process of learning for special needs students during the past three decades. Thanks to this technology, accessibility and educational inclusion became attainable more than any time in the history of special education. Meanwhile, assistive technology devices remain unreachable for a large number of…

Adaptable Learning Assistant for Item Bank Management

ERIC Educational Resources Information Center

Nuntiyagul, Atorn; Naruedomkul, Kanlaya; Cercone, Nick; Wongsawang, Damras

2008-01-01

We present PKIP, an adaptable learning assistant tool for managing question items in item banks. PKIP is not only able to automatically assist educational users to categorize the question items into predefined categories by their contents but also to correctly retrieve the items by specifying the category and/or the difficulty level. PKIP adapts…

Lateglacial vegetation dynamics in the eastern Baltic region between 14,500 and 11,400 cal yr BP: A complete record since the Bølling (GI-1e) to the Holocene

NASA Astrophysics Data System (ADS)

Veski, Siim; Amon, Leeli; Heinsalu, Atko; Reitalu, Triin; Saarse, Leili; Stivrins, Normunds; Vassiljev, Jüri

2012-04-01

This paper discusses a complete record of vegetation history since the Bølling (GI-1e) warming (14,500 cal yr BP) up to the Holocene in Latvia. To date, this is the only complete record of such age in the eastern Baltic area and the northernmost area for which Bølling records are present. Combining pollen evidence, pollen accumulation rates (PAR) and plant macrofossil data, we assess the local and regional vegetation development, and we attempt to separate the true Lateglacial vegetation signal by removing the obviously redeposited thermophilous pollen; however, we remove not only their signal, we discuss the possibilities of separating the redeposition signal of the so-called "local Lateglacial trees", pine and birch, by looking at their corrosion and degradation. The results show that the Bølling warming in the eastern Baltic area was a treeless tundra community consisting of the shrubs Betula nana, Dryas octopetala and Salix polaris. The Older Dryas cold spell is clearly recognised as a decline in the total concentration of plant macrofossils and PARs at between 14,200 and 13,500 cal yr BP. At 13,460 cal yr BP, the B. nana macrofossils disappear, and tree birch (Betula sect. Albae) appears, marking the start of tree birch forest. The presence of pine forest is confirmed by a variety of macrofossils, including bark, wood, needles and seeds, since 13,400 cal yr BP, at the same time at which pine stomata are found. The first identified pine stomata finds are associated with a Pinus PAR over 3000 grains cm-2 yr-1 and pine macrofossil finds with a Pinus PAR over 4000 grains cm-2 yr-1. During the warmest period of the GI-1a (Allerød) at 13,000-12,700 cal yr BP, a pine forest with deciduous trees (birch -Betula pendula and aspen -Populus tremula) developed in the study area. The Younger Dryas (GS-1) cooling strongly affected the floral composition in eastern Latvia. The PAR of the tree taxa declined abruptly from a maximum value at 12,700 to below 1000 grains cm-2 yr-1 at 12,600 cal yr BP. The response time for the pine forest to collapse was 100 years according to the PAR data. Pine macrofossils disappear simultaneously with the pollen signal at 12,600 cal yr BP, yet occasional Pinus stomata are recorded throughout the Younger Dryas (GS-1). The landscape was treeless shrub tundra again, with D. octopetala, S. polaris, B. nana and Juniperus present. Picea is introduced in the region within the cold Younger Dryas and is represented by stomata (12,400-12,200 cal yr BP), needles, seeds and wood (since 12,050 cal yr BP up to the Holocene). The Pleistocene/Holocene boundary at 11,650 cal yr BP is marked by changes both in vegetation composition and sediment type. The organic rich gyttja accumulated instead of silts and clays, and the start of the Holocene warm period permitted forest re-expansion in eastern Latvia.

Enhancing students’ mathematical representation and selfefficacy through situation-based learning assisted by geometer’s sketchpad program

NASA Astrophysics Data System (ADS)

Sowanto; Kusumah, Y. S.

2018-05-01

This research was conducted based on the problem of a lack of students’ mathematical representation ability as well as self-efficacy in accomplishing mathematical tasks. To overcome this problem, this research used situation-based learning (SBL) assisted by geometer’s sketchpad program (GSP). This research investigated students’ improvement of mathematical representation ability who were taught under situation-based learning (SBL) assisted by geometer’s sketchpad program (GSP) and regular method that viewed from the whole students’ prior knowledge (high, average, and low level). In addition, this research investigated the difference of students’ self-efficacy after learning was given. This research belongs to quasi experiment research using non-equivalent control group design with purposive sampling. The result of this research showed that students’ enhancement in their mathematical representation ability taught under SBL assisted by GSP was better than the regular method. Also, there was no interaction between learning methods and students prior knowledge in student’ enhancement of mathematical representation ability. There was significant difference of students’ enhancement of mathematical representation ability taught under SBL assisted by GSP viewed from students’ prior knowledge. Furthermore, there was no significant difference in terms of self-efficacy between those who were taught by SBL assisted by GSP with the regular method.

Developing geogebra-assisted reciprocal teaching strategy to improve junior high school students’ abstraction ability, lateral thinking and mathematical persistence

NASA Astrophysics Data System (ADS)

Priatna, N.; Martadiputra, B. A. P.; Wibisono, Y.

2018-05-01

The development of science and technology requires reform in the utilization of various resources for mathematics teaching and learning process. One of the efforts that can be made is the implementation of GeoGebra-assisted Reciprocal Teaching strategy in mathematics instruction as an effective strategy in improving students’ cognitive, affective, and psychomotor abilities. This research is intended to implement GeoGebra-assisted Reciprocal Teaching strategy in improving abstraction ability, lateral thinking, and mathematical persistence of junior high school students. It employed quasi-experimental method with non-random pre-test and post-test control design. More specifically, it used the 2x3 factorial design, namely the learning factors that included GeoGebra-assisted Reciprocal Teaching and conventional teaching learning, and levels of early mathematical ability (high, middle, and low). The subjects in this research were the eighth grade students of junior high school, taken with purposive sampling. The results of this research show: Abstraction and lateral abilities of students who were taught with GeoGebra-assisted Reciprocal Teaching strategy were significantly higher than those of students who received conventional learning. Mathematical persistence of students taught with GeoGebra-assisted Reciprocal Teaching strategy was also significantly higher than of those taught with conventional learning.

Effects of physical guidance on short-term learning of walking on a narrow beam.

PubMed

Domingo, Antoinette; Ferris, Daniel P

2009-11-01

Physical guidance is often used in rehabilitation when teaching patients to re-learn movements. However, the effects of guidance on motor learning of complex skills, such as walking balance, are not clear. We tested four groups of healthy subjects that practiced walking on a narrow (1.27 cm) or wide (2.5 cm) treadmill-mounted balance beam, with or without physical guidance. Assistance was given by springs attached to a hip belt that applied restoring forces towards beam center. Subjects were evaluated while walking unassisted before and after training by calculating the number of times subjects stepped off of the beam per minute of successful walking on the beam (Failures per Minute). Subjects in Unassisted groups had greater performance improvements in walking balance from pre to post compared to subjects in Assisted groups. During training, Unassisted groups had more Failures per Minute than Assisted groups. Performance improvements were smaller in Narrow Beam groups than in Wide Beam groups. The Unassisted-Wide and Assisted-Narrow groups had similar Failures per Minute during training, but the Unassisted-Wide group had much greater performance gains after training. These results suggest that physical assistance can hinder motor learning of walking balance, assistance appears less detrimental for more difficult tasks, and task-specific dynamics are important to learning independent of error experience.

Effectiveness Of Horizontal Peer-Assisted Learning In Physical Examination Performance.

PubMed

Shah, Inamullah; Mahboob, Usman; Shah, Sajida

2017-01-01

All students cannot be individually trained in physical examination skills due to faculty and time limitations. Peer-assisted learning (PAL) can solve this dilemma if it is used in undergraduate curriculum. Empirical effectiveness of horizontal peer-assisted learning model has not been reported previously. The objective of this study was to compare horizontal peer-assisted learning (PAL) with expert-assisted learning (EAL) in teaching of physical examination skills. This is a randomized controlled study (Solomon four group design) carried out at a medical school. A total of 120 undergraduate year 5 students were randomized into two groups to undergo training in four areas of physical examination. Stratified random sampling technique was used. Group 1 was trained by EAL while Group 2 by PAL. Half students from both groups were given a pre-test to assess the testing effect. Both groups were given a post-test in the form of an OSCE. Independent samples t-test and paired sample t-test were used as tests of significance. Group 2 scored significantly higher than Group 1. There was significant difference (p=.000) in mean post-test scores of Group-1 (69.98±5.6) and Group-2 (85.27±5.6). Difference in mean scores was not significant (p=.977) between students who had taken the pre-test and those who had not. This study has implications in curriculum development as it provides quantitative evidence indicating that horizontal PAL as a learning strategy can actually replace, rather than augment, expert-assisted learning in teaching clinical skills to undergraduate students.

The Effect of English for Specific Purposes (ESP) Learning-Language Lab versus Mobile-Assisted Learning

ERIC Educational Resources Information Center

Shih, Ru-Chu

2017-01-01

In recent years, the rapid advancement of information technology has had a great impact on our daily life and changed the world in which we operate; in particular, mobile devices have become more portable and powerful than ever. As a result, mobile-assisted language learning (MALL) and ubiquitous learning have been widely adopted in a variety of…

The Drive to Strive: An Assistant Principal Reflects on a Career Built on Constant Learning

ERIC Educational Resources Information Center

Osabutey-Aguedje, Tameka

2015-01-01

At different stages of her career, the author has experienced, supported, and facilitated professional learning efforts. As an assistant principal, she finds that she has learned something of value at each stage. In this article, as the author reflects on her career, she realizes that it is important to learn and grow rather than just try to…

The Application of Learning Styles to Computer Assisted Instruction in Nursing Education

DTIC Science & Technology

1991-01-01

nursing profession is to integrate computer technology into the learning process at all levels of nursing education . In order to successfully accomplish... learning styles. * Computer technology needs to be integrated into nursing education , research and practice. * * An evaluation tool needs to be...Computer-assisted video instruction Learning Styles and CAI 71 References Aiken, E. (1990). Continuing nursing education in computer technology : A regional

Twitmographics: Learning the Emergent Properties of the Twitter Community

NASA Astrophysics Data System (ADS)

Cheong, Marc; Lee, Vincent

This paper presents a framework for discovery of the emergent properties of users of the Twitter microblogging platform. The novelty of our methodology is the use of machine-learning methods to deduce user demographic information and online usage patterns and habits not readily apparent from the raw messages posted on Twitter. This is different from existing social network analysis performed on de facto social networks such as Face-book, in the sense that we use publicly available metadata from Twitter messages to explore the inherent characteristics about different segments of the Twitter community, in a simple yet effective manner. Our framework is coupled with the self-organizing map visualization method, and tested on a corpus of messages which deal with issues of socio politi-cal and economic impact, to gain insight into the properties of human interaction via Twitter as a medium for computer-mediated self-expression.

Evaluation of CalMHSA Student Mental Health Online Resources

PubMed Central

Sontag-Padilla, Lisa; Kase, Courtney Ann; Woodbridge, Michelle W.; Stein, Bradley D.

2016-01-01

Abstract Analysis of visitors to CalMHSA-funded student mental health websites shows that visitors at educational institutions comprised the largest audience segment and promotional campaigns likely increased traffic. PMID:28083438

CALS Infrastructure Analysis. Draft. Volume 21

DOT National Transportation Integrated Search

1990-03-01

This executive overview to the DoD CALS Infrastructure Analysis Report summarizes the Components' current effort to modernize the DoD technical data infrastructure. This infrastructure includes all existing and planned capabilities to acquire, manage...

Views of a Cal/OSHA Inspector.

PubMed

Oudiz, Jack

2009-01-01

Retiring CAL/OSHA Industrial Hygienist and Senior Safety Engineer Jack Oudiz offers his thoughts in the nature of a voluntary "exit interview" on his years working for the agency and its performance in its mission.

Measurements of Gases and Aerosols during 2010Cal-Mex

NASA Astrophysics Data System (ADS)

Zheng, J.; Zhang, R.; Molina, L.

2012-04-01

The major goal of the collaborative Cal-Mex 2010 research project is to assess the sources and processing of emissions along the California-Mexico border region and their effects on regional air quality and climate in order to provide scientific information to decision makers of both nations when addressing these two inter-related issues. During the Cal-Mex 2010 field study, the TAMU teams have collected extensive data sets from Tijuana/San Diego border, including volatile organic compounds (VOCs), gaseous sulfuric acid (H2SO4) and a suite set of physical and chemical parameters of aerosols. This comprehensive data set requires additional effort to process and analyze the measurements of gases and aerosols during Cal-Mex 2010. In this talk, preliminary data analysis of gases and aerosols will be presented, including VOCs and particle mixing states, morphology, and effective densities.

Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate

DOE PAGES

Cao, Hongnan; Tan, Kemin; Wang, Fengbin; ...

2016-04-29

CalE6 from Micromonospora echinospora is a (pyridoxal 50 phosphate) PLP-dependent methionine γ-lyase involved in the biosynthesis of calicheamicins. Here, we report the crystal structure of a CalE6 2-(N-morpholino)ethanesulfonic acid complex showing ligand-induced rotation of Tyr100, which stacks with PLP, resembling the corresponding tyrosine rotation of true catalytic intermediates of CalE6 homologs. Elastic network modeling and crystallographic ensemble refinement reveal mobility of the N-terminal loop, which involves both tetrameric assembly and PLP binding. Modeling and comparative structural analysis of PLP-dependent enzymes involved in Cys/Met metabolism shine light on the functional implications of the intrinsic dynamic properties of CalE6 in catalysis andmore » holoenzyme maturation.« less

Coronary calcium visualization using dual energy chest radiography with sliding organ registration

NASA Astrophysics Data System (ADS)

Wen, Di; Nye, Katelyn; Zhou, Bo; Gilkeson, Robert C.; Wilson, David L.

2016-03-01

Coronary artery calcification (CAC) is the lead biomarker for atherosclerotic heart disease. We are developing a new technique to image CAC using ubiquitously ordered, low cost, low radiation dual energy (DE) chest radiography (using the two-shot GE Revolution XRd system). In this paper, we proposed a novel image processing method (CorCalDx) based on sliding organ registration to create a bone-image-like, coronary calcium image (CCI) that significantly reduces motion artifacts and improves CAC conspicuity. Experiments on images of a physical dynamic cardiac phantom showed that CorCalDx reduced 73% of the motion artifact area as compared to standard DE over a range of heart rates up to 90 bpm and varying x-ray radiation exposures. Residual motion artifact in the phantom CCI is greatly suppressed in gray level and area (0.88% of the heart area). In a Functional Measurement Test (FMT) with 20 clinical exams, image quality improvement of CorCalDx against standard DE (measured from -10 to +10) was significantly suggested (p<0.0001) by three radiologists for cardiac motion artifacts (7.2+/-2.1) and cardiac anatomy visibility (6.1+/-3.5). CorCalDx was always chosen best in every image tested. In preliminary assessments of 12 patients with 18 calcifications, 90% of motion artifact regions in standard DE results were removed in CorCalDx results, with 100% sensitivity of calcification detection, showing great potential of CorCalDx to improve CAC detection and grading in DE chest radiography.

Anthocyanins from black rice (Oryza sativa L.) demonstrate antimetastatic properties by reducing MMPs and NF-κB expressions in human oral cancer CAL 27 cells.

PubMed

Fan, Ming-Jen; Wang, I-Chen; Hsiao, Yung-Ting; Lin, Hui-Yi; Tang, Nou-Ying; Hung, Tzu-Chieh; Quan, Christine; Lien, Jin-Cherng; Chung, Jing-Gung

2015-01-01

Aside from the commonly known white rice lines, colored varieties also exist. These varieties have historically been used in Chinese medicine. Anthocyanins, a large group of natural polyphenols existing in a variety of daily fruits and vegetables, have been widely recognized as cancer chemopreventive agents. The primary objective of cancer treatment strategies has traditionally focused on preventing the occurrence of metastasis. In this research the antimetastatic mechanism of anthocyanins on the invasion/migration of human oral CAL 27 cells was performed using a transwell to quantify the migratory potential of CAL 27 cells and the results show that anthocyanins can inhibit the in vitro migration and invasion of CAL 27 cancer cells. In addition, the gelatin zymography assay indicated that anthocyanins inhibited the activity of matrix metalloproteinases-2 (MMP-2). Western blotting assay also demonstrated that anthocyanins inhibited the associated protein expression of migration/invasion of CAL 27 cell. Immunofluorescence staining proved that anthocyanins inhibited nuclear factor kappa B p65 (NF-κB p65) expressions. These results demonstrated that anthocyanins from a species of black rice (selected purple glutinous indica rice cultivated at Asia University) could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-κB p65 expression through the suppression of PI3K/Akt pathway and inhibition of NF-κB levels.

Stable isotope ratios in swale sequences of Lake Superior as indicators of climate and lake level fluctuations during the Late Holocene

USGS Publications Warehouse

Sharma, Shruti; Mora, G.; Johnston, J.W.; Thompson, T.A.

2005-01-01

Beach ridges along the coastline of Lake Superior provide a long-term and detailed record of lake level fluctuations for the past 4000 cal BP. Although climate change has been invoked to explain these fluctuations, its role is still in debate. Here, we reconstruct water balance by employing peat samples collected from swale deposits present between beach ridge sequences at two locations along the coastline of Lake Superior. Carbon isotope ratios for Sphagnum remains from these peat deposits are used as a proxy for water balance because the presence or absence of water films on Sphagnum controls the overall isotope discrimination effects. Consequently, increased average water content in Sphagnum produces elevated ??13C values. Two maxima of Sphagnum ??13C values interpreted to reflect wetter conditions prevailed from 3400 to 2400 cal BP and from about 1900 to 1400 cal BP. There are two relatively short drier periods as inferred from low Sphagnum ??13C values: one is centered at about 2300 cal BP, and one begins at 1400 cal BP. A good covariance was found between Sphagnum ??13C values and reconstructed lake-levels for Lake Michigan in which elevated carbon isotope values correlate well with higher lake levels. Based on this covariance, we conclude that climate exerts a strong influence on lake levels in Lake Superior for the past 4000 cal BP. ?? 2005 Elsevier Ltd. All rights reserved.

The stability of hydrogen ion and specific conductance in filtered wet-deposition samples stored at ambient temperatures

USGS Publications Warehouse

Gordon, J.D.; Schroder, L.J.; Morden-Moore, A. L.; Bowersox, V.C.

1995-01-01

Separate experiments by the U.S. Geological Survey (USGS) and the Illinois State Water Survey Central Analytical Laboratory (CAL) independently assessed the stability of hydrogen ion and specific conductance in filtered wet-deposition samples stored at ambient temperatures. The USGS experiment represented a test of sample stability under a diverse range of conditions, whereas the CAL experiment was a controlled test of sample stability. In the experiment by the USGS, a statistically significant (?? = 0.05) relation between [H+] and time was found for the composited filtered, natural, wet-deposition solution when all reported values are included in the analysis. However, if two outlying pH values most likely representing measurement error are excluded from the analysis, the change in [H+] over time was not statistically significant. In the experiment by the CAL, randomly selected samples were reanalyzed between July 1984 and February 1991. The original analysis and reanalysis pairs revealed that [H+] differences, although very small, were statistically different from zero, whereas specific-conductance differences were not. Nevertheless, the results of the CAL reanalysis project indicate there appears to be no consistent, chemically significant degradation in sample integrity with regard to [H+] and specific conductance while samples are stored at room temperature at the CAL. Based on the results of the CAL and USGS studies, short-term (45-60 day) stability of [H+] and specific conductance in natural filtered wet-deposition samples that are shipped and stored unchilled at ambient temperatures was satisfactory.

Revealing climatic variability of the last three millennia in northwestern Iberia using pollen influx data

NASA Astrophysics Data System (ADS)

Desprat, Stéphanie; Sánchez Goñi, María. Fernanda; Loutre, Marie-France

2003-08-01

Climatic variability of the last 3 millennia in NW Iberia has been documented using high-resolution pollen analysis of Vir-18 core, retrieved from the Ría de Vigo (42°14.07‧N, 8°47.37‧W). The depth-age model is based on two accelerator mass spectrometry 14C dates and three historically dated botanical events in Galicia: the expansion of Juglans and Pinus, as well as the introduction of Eucalyptus. During the last 3000 years, the relative pollen record demonstrates the occurrence of an open deciduous oak forest, indicating a humid and temperate climate in northwestern Iberia. Two-step forest reduction since 975 cal BC suggests climate as the main cause rather than major socio-economic changes documented in historical archives. Absolute pollen influx has been compared with instrumental summer and winter temperatures and tentatively used as a proxy of short (decadal-scale) and low-amplitude (˜1°C) temperature variations. This new approach allows us to detect for the first time in NW Iberia the millennial-scale climatic cyclicity suggested by North Atlantic records, challenging the apparent climatic stability reflected by the relative pollen record. The Little Ice Age is recorded as low pollen influx values between 1400 and 1860 cal AD, with a cold maximum at 1700 cal AD (Maunder Minimum). The Roman and Medieval Warm Periods are detected through high pollen influx values at 250 cal BC-450 cal AD and 950-1400 cal AD, respectively.

Late Quaternary dynamics of forest vegetation on northern Vancouver Island, British Columbia, Canada

NASA Astrophysics Data System (ADS)

Lacourse, Terri

2005-01-01

Pollen analysis of radiocarbon-dated lake sediment from northern Vancouver Island, southwest British Columbia reveals regional changes in forest vegetation over the last 12,200 14C yr (14,900 cal yr). Between at least 12,200 and 11,700 14C yr BP (14,900-13,930 cal yr BP), open woodlands were dominated by Pinus contorta, Alnus crispa, and various ferns. As P. contorta decreased in abundance, Alnus rubra and more shade-tolerant conifers (i.e., Picea and Tsuga mertensiana) increased. Increases in T. mertensiana, P. contorta, and A. crispa pollen accumulation rates (PARs) between 10,600 and 10,400 14C yr BP (11,660-11,480 cal yr BP) reflect a cool and moist climate during the Younger Dryas chronozone. Orbitally induced warming around 10,000 14C yr BP (11,090 cal yr BP) allowed the northward extension of Pseudotsuga menziesii, although Picea, Tsuga heterophylla, and A. rubra dominated early Holocene forests. By 7500 14C yr BP (8215 cal yr BP), shade-tolerant T. heterophylla was the dominant forest tree. Cupressaceae ( Thuja plicata and Chamaecyparis nootkatensis) was present by 7500 14C yr BP but reached its maximum after 3500 14C yr BP (3600 cal yr BP), when a cooler and wetter regional climate facilitated the development of temperate rainforest. The highest rates of vegetation change are associated with Lateglacial climate change and species with rapid growth rates and short life spans.

CAMPARE and Cal-Bridge: Two Institutional Networks Increasing Diversity in Astronomy

NASA Astrophysics Data System (ADS)

Rudolph, Alexander L.; Impey, Chris David; Smecker-Hane, Tammy A.

2016-01-01

We describe two programs, CAMPARE and Cal-Bridge, with the common mission of increasing participation of groups traditionally underrepresented in astronomy, through summer research opportunities, in the case of CAMPARE, scholarships in the case of Cal-Bridge, and significant mentoring in both programs, leading to an increase in their numbers successfully pursuing a PhD in the field.In 6 years, the CAMPARE program has sent 62 students, >85% from underrepresented groups, to conduct summer research at one of twelve major research institutions in California, Arizona, and Wyoming. The graduation rate among CAMPARE scholars is 97%, and of the 37 CAMPARE scholars who have graduated with a Bachelor's degree, almost 60% (21) have completed or are pursuing graduate education in astronomy or a related field, at institutions including UCLA, USC, UC Riverside, Stanford, Univ. of Rochester, Georgia Tech, Kent State, Indiana Univ., Univ. of Oregon, Syracuse, and the Fisk-Vanderbilt Master's-to-PhD program. The Cal-Bridge program is a CSU-UC Bridge program comprised of faculty form 5 University of California (UC), 8 California State University (CSU), and 8 California Community College (CCC) campuses in Southern California. Cal-Bridge provides much deeper mentoring and professional development experiences over the last two years of undergraduate and first year of graduate school to students from this diverse network of higher education institutions. Cal-Bridge Scholars benefit from financial support, intensive, joint mentoring by CSU and UC faculty, professional development workshops, and exposure to research opportunities at the participating UC campuses.

Using assistive technology adaptations to include students with learning disabilities in cooperative learning activities.

PubMed

Bryant, D P; Bryant, B R

1998-01-01

Cooperative learning (CL) is a common instructional arrangement that is used by classroom teachers to foster academic achievement and social acceptance of students with and without learning disabilities. Cooperative learning is appealing to classroom teachers because it can provide an opportunity for more instruction and feedback by peers than can be provided by teachers to individual students who require extra assistance. Recent studies suggest that students with LD may need adaptations during cooperative learning activities. The use of assistive technology adaptations may be necessary to help some students with LD compensate for their specific learning difficulties so that they can engage more readily in cooperative learning activities. A process for integrating technology adaptations into cooperative learning activities is discussed in terms of three components: selecting adaptations, monitoring the use of the adaptations during cooperative learning activities, and evaluating the adaptations' effectiveness. The article concludes with comments regarding barriers to and support systems for technology integration, technology and effective instructional practices, and the need to consider technology adaptations for students who have learning disabilities.

Mineral magnetism and other characteristics of sediments from a sub-alpine lake (3080 m a.s.l.) in central east China and their implications on environmental changes for the last 5770 years

NASA Astrophysics Data System (ADS)

Wang, Hongya; Song, Yaqiong; Cheng, Ying; Luo, Yao; Zhang, Cai'na; Gao, Yishen; Qiu, An'an; Deng, Lei; Liu, Hongyan

2016-10-01

A sediment sequence (SQC07) was recovered from Sanqing Chi, a small sub-alpine lake (3080 m a.s.l.) on Taibai (3767 m a.s.l.), the highest mountain in east mainland China (east of 105°). The Mountain is also the highest part and central massif of the Qinling Mountain Range functioning as the boundary between the warm temperate climate zone to the north and sub-tropical climate zone to the south in east China. Soils and debris were also sampled from the catchment of Sanqing Chi. SQC07 was AMS 14C dated. Mineral magnetism was measured for the sediment sequence and catchment samples. Particle-size, TOC and TN analysis were undertaken on SQC07, while pollen analysis was made for the sediment sequence and surface-soil samples. With the mineral magnetism of the catchment materials, the magnetic and other characteristics of SQC07 indicate the environmental changes occurring on the high altitudes of Taibai Mountain during the past 5770 years. Environments were still moderately warm and wet over 5770-5100 cal. yr BP around this sub-alpine lake. Then cold and dry conditions persisted in the period of 5100-4000 cal. yr BP. Local environments began to ameliorate from 4000 cal. yr BP onwards and were thus generally warm and wet over 4000-1200 cal. yr BP. The warmth and wetness culminated in 1200-800 cal. yr BP. During the period of 800-400 cal. yr BP, cold and arid conditions again predominated. Environments have subsequently become warm and humid since ∼400 cal. yr BP. The overall trend of the changes is coincident with what have been identified at several other sites in east mainland China and Taiwan. Presumably, the deterioration over 5100-4000 cal. yr BP marks the termination of the Holocene optimum, corresponds to or encompasses Holocene event 3, while the deterioration occurring in 800-400 cal. yr BP may correspond to LIA cooling. However, they appear to have commenced earlier than the aforementioned sites at relatively low altitudes in east mainland China or even higher altitudes but far southeast in Taiwan. These differences are possibly caused partly by uncertainties and/or errors of chronologies. Nevertheless, they also could be attributed to the spatial variability of East Asian monsoon and/or earlier responses of local landscapes around Sanqing Chi to larger-scale climate-deterioration.

Lorma: A Reference Handbook of Phonetics, Grammar, Lexicon and Learning Procedures.

ERIC Educational Resources Information Center

Dwyer, David James

The grammar, phonetics, and lexicon of Lorma, one of the Mande languages of Liberia, are described for the use of Peace Corps volunteers learning the language without teacher assistance. This handbook includes an introduction to the languages of Liberia, procedures for learning a language without assistance, guidelines for tutors, a reference…

Introducing Case-Based Peer-Assisted Learning in a Professional Course

ERIC Educational Resources Information Center

Hodgson, Yvonne; Brack, Charlotte; Benson, Robyn

2014-01-01

This paper describes students' experience of participating in a case-based peer-assisted learning (PAL) program in order to examine whether the approach is pedagogically effective and likely to contribute to students' professional development. It presents the findings of a study which examined the integration of PAL and case-based learning (CBL)…

Attitudes of Jordanian Undergraduate Students towards Using Computer Assisted Language Learning (CALL)

ERIC Educational Resources Information Center

Saeed, Farah Jamal Abed Alrazeq; Al-Zayed, Norma Nawaf

2018-01-01

The study aimed at investigating the attitudes of Jordanian undergraduate students towards using computer assisted-language learning (CALL) and its effectiveness in the process of learning the English language. In order to fulfill the study's objective, the researchers used a questionnaire to collect data, followed-up with semi-structured…

Skills for Support: Personal Assistants and People with Learning Disabilities

ERIC Educational Resources Information Center

Williams, Val; Ponting, Lisa; Ford, Kerrie; Rudge, Philippa

2010-01-01

For people with learning disabilities to have control over their lives, the quality of their support staff matters. This paper reports on an inclusive research study, which used video analysis to study the communication skills of personal assistants (PAs) who worked with people with learning disabilities. The findings reveal some of the fine…

Mobile Assisted Language Learning: Review of the Recent Applications of Emerging Mobile Technologies

ERIC Educational Resources Information Center

Yang, Jaeseok

2013-01-01

As mobile computing technologies have been more powerful and inclusive in people's daily life, the issue of mobile assisted language learning (MALL) has also been widely explored in CALL research. Many researches on MALL consider the emerging mobile technologies have considerable potentials for the effective language learning. This review study…

eTeacher: Providing Personalized Assistance to E-Learning Students

ERIC Educational Resources Information Center

Schiaffino, Silvia; Garcia, Patricio; Amandi, Analia

2008-01-01

In this paper we present eTeacher, an intelligent agent that provides personalized assistance to e-learning students. eTeacher observes a student's behavior while he/she is taking online courses and automatically builds the student's profile. This profile comprises the student's learning style and information about the student's performance, such…

Peer Assisted Learning in the Clinical Setting: An Activity Systems Analysis

ERIC Educational Resources Information Center

Bennett, Deirdre; O'Flynn, Siun; Kelly, Martina

2015-01-01

Peer assisted learning (PAL) is a common feature of medical education. Understanding of PAL has been based on processes and outcomes in controlled settings, such as clinical skills labs. PAL in the clinical setting, a complex learning environment, requires fresh evaluation. Socio-cultural theory is proposed as a means to understand educational…

The Strategic Thinking and Learning Community: An Innovative Model for Providing Academic Assistance

ERIC Educational Resources Information Center

Commander, Nannette Evans; Valeri-Gold, Maria; Darnell, Kim

2004-01-01

Today, academic assistance efforts are frequently geared to all students, not just the underprepared, with study skills offered in various formats. In this article, the authors describe a learning community model with the theme, "Strategic Thinking and Learning" (STL). Results of data analysis indicate that participants of the STL…

RASCAL: A Rudimentary Adaptive System for Computer-Aided Learning.

ERIC Educational Resources Information Center

Stewart, John Christopher

Both the background of computer-assisted instruction (CAI) systems in general and the requirements of a computer-aided learning system which would be a reasonable assistant to a teacher are discussed. RASCAL (Rudimentary Adaptive System for Computer-Aided Learning) is a first attempt at defining a CAI system which would individualize the learning…

Income Tax Preparation Assistance Service Learning Program: A Multidimensional Assessment

ERIC Educational Resources Information Center

Aldridge, Richard; Callahan, Richard A.; Chen, Yining; Wade, Stacy R.

2015-01-01

The authors present a multidimensional assessment of the outcomes and benefits of an income tax preparation assistance (ITPA) service learning program. They measure the perceived proximate benefits at the delivery of the service program, the actual learning outcome benefits prior to graduation, and the perceived long-term benefits from a…

The Effect of Adaptive Confidence Strategies in Computer-Assisted Instruction on Learning and Learner Confidence

ERIC Educational Resources Information Center

Warren, Richard Daniel

2012-01-01

The purpose of this research was to investigate the effects of including adaptive confidence strategies in instructionally sound computer-assisted instruction (CAI) on learning and learner confidence. Seventy-one general educational development (GED) learners recruited from various GED learning centers at community colleges in the southeast United…

Enzyme-Catalyzed Regioselective Modification of Starch Nanoparticles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chakraborty, Soma; Sahoo, Bishwabhusan; Teraoka, Iwao

The selective esterification of starch nanoparticles was performed using as catalyst Candida antartica Lipase B (CAL-B) in its immobilized (Novozym 435) and free (SP-525) forms. The starch nanoparticles were made accessible for acylation reactions by formation of Aerosol-OT (AOT, bis(2-ethylhexyl)sodium sulfosuccinate) stabilized microemulsions. Starch nanoparticles in microemulsions were reacted with vinyl stearate, ε-caprolactone, and maleic anhydride at 40 °C for 48 h to give starch esters with degrees of substitution (DS) of 0.8, 0.6, and 0.4, respectively. Substitution occurred regioselectively at the C-6 position of the glucose repeat units. Infrared microspectroscopy (IRMS) revealed that AOT-coated starch nanoparticles diffuse into themore » outer 50 μm shell of catalyst beads. Thus, even though CAL-B is immobilized within a macroporous resin, CAL-B is sufficiently accessible to the starch nanoparticles. When free CAL-B was incorporated along with starch within AOT-coated reversed micelles, CAL-B was also active and catalyzed the acylation with vinyl stearate (24 h, 40 °C) to give DS = 0.5. After removal of surfactant from the modified starch nanoparticles, they were dispersed in DMSO or water and were shown to retain their nanodimensions.« less

Direct pulp capping in primary molars using a resin-modified Portland cement-based material (TheraCal) compared to MTA with 12-month follow-up: a randomised clinical trial.

PubMed

Erfanparast, L; Iranparvar, P; Vafaei, A

2018-05-16

This study was to compare the success of resin-modified Portland cement-based material (TheraCal) with MTA in direct pulp capping (DPC) of primary molars. Symmetrical bilateral primary molars (92) from 46 healthy subjects aged 5-7 years were included in this split-mouth randomised clinical trial. DPC for small non-contaminated pulp exposures using either TheraCal or MTA were randomly performed in symmetrical molars. Thereafter, teeth were restored with amalgam. Clinical and radiographic evaluations were performed at 6 and 12 month follow-ups. Data were analysed using Chi square test at a significance level of 0.05. At the final follow-up session 74 teeth were available. After 12 months, the overall success rates for MTA and TheraCal were 94.5 and 91.8%, respectively. The difference between outcomes of the two groups was not statistically significant (P > 0.05). Within the limitations of the current study, radiographic and clinical findings revealed that TheraCal exhibited a comparable outcome to MTA in DPC of primary molars after 12 months.

Timing of atmospheric precipitation in the Zagros Mountains inferred from a multi-proxy record from Lake Mirabad, Iran

NASA Astrophysics Data System (ADS)

Stevens, Lora R.; Ito, Emi; Schwalb, Antje; Wright, Herbert E.

2006-11-01

A sediment core 7.2 m long from Lake Mirabad, Iran, was examined for loss-on-ignition, mineralogy, oxygen-isotopic composition of authigenic calcite, and trace-element composition of ostracodes to complement earlier pollen and ostracode-assemblage studies. Pollen, ostracode-inferred lake level, and high Sr/Ca ratios indicate that the early Holocene (10000 to 6500 cal yr BP) was drier than the late Holocene. Low δ18O values during this interval are interpreted as resulting from winter-dominated precipitation, characteristic of a Mediterranean climate. Increasing δ18O values after 6500 cal yr BP signal a gradual increase in spring rains, which are present today. A severe 600-yr drought occurred at ca. 5500 cal yr BP, shortly after the transition from pistachio-almond to oak forest. During the late Holocene, two milder droughts occurred at about 1500 and 500 cal yr BP. Within the resolution of the record, no drought is evident during the collapse of the Akkadian empire (4200-3900 cal yr BP). Rather, a decrease in δ18O values to early-Holocene levels may indicate the return to a Mediterranean precipitation regime.

Determination of chemical properties in 'calçot' (Allium cepa L.) by near infrared spectroscopy and multivariate calibration.

PubMed

Sans, Silvia; Ferré, Joan; Boqué, Ricard; Sabaté, José; Casals, Joan; Simó, Joan

2018-10-01

'Calçots', the immature floral stems of second-year onion resprouts, are an economically important traditional crop in Catalonia (Spain). Classical approaches to evaluating the chemical properties of 'calçots' are time consuming and expensive; near-infrared spectroscopy (NIRS) may be faster and cheaper. We used NIRS to develop partial least square (PLS) models to predict dry matter, soluble solid content, titratable acidity, and ash content in cooked 'calçots'. To guarantee the robustness of the models, calibration samples were grown and analyzed in a first season (2014-15) and validation samples in a second season (2015-16). NIRS on puree spectra estimated dry matter and soluble solid content with excellent accuracy (R 2 pred  = 0.953, 0.985 and RPD = 4.571, 8.068, respectively). However, good estimation of titratable acidity and ash content required using ground dried puree spectra (R 2 pred  = 0.852, 0.820 and RPD = 2.590, 1.987, respectively). NIRS can be a helpful tool for 'calçots' breeding and quality control. Copyright © 2018 Elsevier Ltd. All rights reserved.

Strong Altitudinal Control on Local Glacier's Response to Holocene Climate Change in Southwest Greenland

NASA Astrophysics Data System (ADS)

Larsen, N. K.; Levy, L.; Strunk, A.; Bjork, A. A.; Olsen, J.; Jeppesen, E.; Lauridsen, T.; Davidson, T. A.

2017-12-01

The sensitivity of glaciers and ice caps (GICs) in Greenland to prolonged warm periods is poorly constrained and geological records documenting the long-term glacial history are needed to put recent observations into a broader perspective. Here we report the results from three proglacial lakes where fluctuations in local glaciers located at different altitudes in Kobbefjord, southwest Greenland have been recorded. Our results show that the lakes received meltwater from the initial deglaciation of the area 9.2 cal. ka BP until 8.7-7.9 cal. ka BP when the meltwater input ceased as the glaciers most likely disappeared. Regrowth of glaciers began again at 5.5 cal. ka BP at 1,370 m a.s.l., 3.6 cal. ka at 1,170 m a.s.l., and 1.6 cal. ka BP at 1,000 m a.s.l., clearly reflecting strong altitudinal control of the GIC response to Neoglacial cooling. Our results highlight that GICs in Kobbefjord, southwest Greenland are primarily influenced by changes in summer air temperatures and winter precipitation and that they are facing a rapid decay that most likely will result in their disappearance within the next centuries as a consequence of global warming.

Postglacial vegetation history of Orcas Island, northwestern Washington

NASA Astrophysics Data System (ADS)

Leopold, Estella B.; Dunwiddie, Peter W.; Whitlock, Cathy; Nickmann, Rudy; Watts, William A.

2016-05-01

The revegetation of islands following retreat of Pleistocene glaciers is of great biogeographical interest. The San Juan Islands, Washington, feature regionally distinctive xerophytic plant communities, yet their vegetation history, as it relates to past climate and sea level, is poorly known. We describe a 13,700-year-old pollen record from Killebrew Lake Fen and compare the vegetation reconstruction with others from the region. The data suggest that the narrow channels surrounding Orcas Island were not a barrier to early postglacial immigration of plants. Between 13,700 and 12,000 cal yr BP, Pinus, Tsuga, Picea, Alnus viridis, and possibly Juniperus maritima were present in a mosaic that supported Bison antiquus and Megalonyx. The rise of Alnus rubra-type pollen and Pteridium spores at ca. 12,000 cal yr BP suggests a warming trend and probably more fires. Temperate conifer taxa, including Cupressaceae, Pseudotsuga, Tsuga heterophylla, and Abies, increased after 11,000 cal yr BP and especially in the last 7000 cal yr BP. After 6000 cal yr BP, Pseudotsuga and Cupressaceae dominated the vegetation. The last 1500 yr were the wettest period of the record. Due to its rain shadow location, Orcas Island experienced drier conditions than on the mainland during most of the postglacial period.

Using computer assisted learning for clinical skills education in nursing: integrative review.

PubMed

Bloomfield, Jacqueline G; While, Alison E; Roberts, Julia D

2008-08-01

This paper is a report of an integrative review of research investigating computer assisted learning for clinical skills education in nursing, the ways in which it has been studied and the general findings. Clinical skills are an essential aspect of nursing practice and there is international debate about the most effective ways in which these can be taught. Computer assisted learning has been used as an alternative to conventional teaching methods, and robust research to evaluate its effectiveness is essential. The CINAHL, Medline, BNI, PsycInfo and ERIC electronic databases were searched for the period 1997-2006 for research-based papers published in English. Electronic citation tracking and hand searching of reference lists and relevant journals was also undertaken. Twelve studies met the inclusion criteria. An integrative review was conducted and each paper was explored in relation to: design, aims, sample, outcome measures and findings. Many of the study samples were small and there were weaknesses in designs. There is limited empirical evidence addressing the use of computer assisted learning for clinical skills education in nursing. Computer assisted learning has been used to teach a limited range of clinical skills in a variety of settings. The paucity of evaluative studies indicates the need for more rigorous research to investigate the effect of computer assisted learning for this purpose. Areas that need to be addressed in future studies include: sample size, range of skills, longitudinal follow-up and control of confounding variables.

A strategy for quantum algorithm design assisted by machine learning

NASA Astrophysics Data System (ADS)

Bang, Jeongho; Ryu, Junghee; Yoo, Seokwon; Pawłowski, Marcin; Lee, Jinhyoung

2014-07-01

We propose a method for quantum algorithm design assisted by machine learning. The method uses a quantum-classical hybrid simulator, where a ‘quantum student’ is being taught by a ‘classical teacher’. In other words, in our method, the learning system is supposed to evolve into a quantum algorithm for a given problem, assisted by a classical main-feedback system. Our method is applicable for designing quantum oracle-based algorithms. We chose, as a case study, an oracle decision problem, called a Deutsch-Jozsa problem. We showed by using Monte Carlo simulations that our simulator can faithfully learn a quantum algorithm for solving the problem for a given oracle. Remarkably, the learning time is proportional to the square root of the total number of parameters, rather than showing the exponential dependence found in the classical machine learning-based method.

Evaluation of the benefits of assistive reading software: perceptions of high school students with learning disabilities.

PubMed

Chiang, Hsin-Yu; Liu, Chien-Hsiou

2011-01-01

Using assistive reading software may be a cost-effective way to increase the opportunity for independent learning in students with learning disabilities. However, the effectiveness and perception of assistive reading software has seldom been explored in English-as-a-second language students with learning disabilities. This research was designed to explore the perception and effect of using assistive reading software in high school students with dyslexia (one subtype of learning disability) to improve their English reading and other school performance. The Kurzweil 3000 software was used as the intervention tool in this study. Fifteen students with learning disabilities were recruited, and instruction in the usage of the Kurzweil 3000 was given. Then after 2 weeks, when they were familiarized with the use of Kurzweil 3000, interviews were used to determine the perception and potential benefit of using the software. The results suggested that the Kurzweil 3000 had an immediate impact on students' English word recognition. The students reported that the software made reading, writing, spelling, and pronouncing easier. They also comprehended more during their English class. Further study is needed to determine under which conditions certain hardware/software might be helpful for individuals with special learning needs.

"Learning to Assess" and "Assessing to Learn": The Construction of Knowledge about Assistive Technology

ERIC Educational Resources Information Center

Folkes, Clare; Carmichael, Patrick

2006-01-01

A key role in the development and deployment of Assistive Technology solutions is that of the "assessor-consultant". Assessor-consultants for the UK-based charity Abilitynet work with clients to develop customized computer-based assistive technology systems and draw on a range of shared knowledge from the assessor-consultant community.…

From the Campus to the Cloud: The Online Peer Assisted Learning Scheme

ERIC Educational Resources Information Center

Beaumont, Tim J.; Mannion, Aaron P.; Shen, Brice O.

2012-01-01

This paper reports on an online version of Peer Assisted Study Sessions (PASS), also known as Supplemental Instruction (SI), which was trialled in two subjects in the University of Melbourne in 2011. The program, named the Online Peer Assisted Learning (OPAL) scheme, was implemented with the aims of extending the benefits of a successful peer…

The Identification, Implementation, and Evaluation of Critical User Interface Design Features of Computer-Assisted Instruction Programs in Mathematics for Students with Learning Disabilities

ERIC Educational Resources Information Center

Seo, You-Jin; Woo, Honguk

2010-01-01

Critical user interface design features of computer-assisted instruction programs in mathematics for students with learning disabilities and corresponding implementation guidelines were identified in this study. Based on the identified features and guidelines, a multimedia computer-assisted instruction program, "Math Explorer", which delivers…

Professional Learning for Teaching Assistants and Its Effect on Classroom Roles

ERIC Educational Resources Information Center

Hurst, Chris; Sparrow, Len

2012-01-01

The Swan Valley Cluster of schools for the Make It Count project identified the professional learning of teachers and teaching assistants as a key factor in improving numeracy outcomes for urban Indigenous children. Initial training for assistants began in late 2010 and took the form of workshops based on a modified First Steps in Mathematics…

Using Assistive Technology in Teaching Children with Learning Disabilities in the 21st Century

ERIC Educational Resources Information Center

Adebisi, Rufus Olanrewaju; Liman, Nalado Abubakar; Longpoe, Patricia Kwalzoom

2015-01-01

This paper was written to expose the meaning, benefits, and answer why the use of assistive technology for children with learning disabilities. The paper discussed the various types of assistive technology devices that were designed and used to solve written language, reading, listening, memory and mathematic problems of children with learning…

Training the Foot Soldiers of Inquiry: Development and Evaluation of a Graduate Teaching Assistant Learning Community

ERIC Educational Resources Information Center

Linenberger, Kimberly; Slade, Michael C.; Addis, Elizabeth A.; Elliott, Emily R.; Mynhardt, Glené; Raker, Jeffrey R.

2014-01-01

As part of a Howard Hughes Program for Innovation in Science Education grant at Iowa State University, a series of interdisciplinary graduate teaching assistant learning communities (TALC) were developed. The purpose of these communities was to create an environment to facilitate teaching assistants' pedagogical development and training to enhance…

Making a Quit Plan

MedlinePlus

... activity to calendar Google Calendar iCal Outlook × 1 week smokefree Being smokefree for a week is a ... to calendar Google Calendar iCal Outlook × First Two Weeks What to expect: Most withdrawal symptoms will fade ...

Innovation in engineering education through computer assisted learning and virtual university model

NASA Astrophysics Data System (ADS)

Raicu, A.; Raicu, G.

2015-11-01

The paper presents the most important aspects of innovation in Engineering Education using Computer Assisted Learning. The authors propose to increase the quality of Engineering Education programs of study at European standards. The use of computer assisted learning methodologies in all studies is becoming an important resource in Higher Education. We intend to improve the concept of e-Learning using virtual terminals, online support and assisting special training through live seminars and interactive labs to develop a virtual university model. We intend to encourage computer assisted learning and innovation as sources of competitive advantage, to permit vision and learning analysis, identifies new sources of technology and ideas. Our work is based on our university datasets collected during last fifteen years using several e-Learning systems. In Constanta Maritime University (CMU), using eLearning and Knowledge Management Services (KMS) is very important and we apply it effectively to achieve strategic objectives, such as collaboration, sharing and good practice. We have experience in this field since 2000 year using Moodle as KMS in our university. The term KMS can be associated to Open Source Software, Open Standards, Open Protocols and Open Knowledge licenses, initiatives and policies. In CMU Virtual Campus we have today over 12500 active users. Another experience of the authors is the implementation of MariTrainer Wiki educational platform based on Dokeos and DekiWiki under MARICOMP and MEP Leonardo da Vinci Project. We'll also present in this paper a case study under EU funded project POSDRU, where the authors implemented other educational platform in Technological High Schools from Romania used over 1000 teachers. Based on large datasets the study tries to improve the concept of e-Learning teaching using the revolutionary technologies. The new concept present in this paper is that the teaching and learning will be interactive and live. The new and modern techniques are the flexible learning courses, the production of learning demonstrators and testing. All the information from the virtual educational platform remain open space, communication between participants and continued after graduation, so we can talk about creating and maintaining a community of graduates, a partnership with them. Every European University must have a department which aims to provide computer assisted learning using knowledge creation through learning, capture and explication, sharing and collaborative communication, access, use and reuse and knowledge archiving.

Fast simulation of electromagnetic and hadronic showers in SpaCal calorimeter at the H1 experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raičević, Nataša, E-mail: raicevic@mail.desy.de; Glazov, Alexandre

2016-03-25

The fast simulation of showers induced by electrons (positrons) in the H1 lead/scintillating-fiber calorimeter, SpaCal, based on shower library technique has been presented previously. In this paper we show the results on linearity and uniformity of the reconstructed electron/positron cluster energy in electromagnetic section of Spacal for the simulations based on shower library and GFLASH shower parametrisation. The shapes of the clusters originating from photon and hadron candidates in SpaCal are analysed and experimental distributions compared with the two simulations.