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Sample records for astatine 218

  1. Atomic Mass and Nuclear Binding Energy for At-218 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-218 (Astatine, atomic number Z = 85, mass number A = 218).

  2. Radiochemistry of astatine

    SciTech Connect

    Ruth, T J; Dombsky, M; D'Auria, J M; Ward, T E

    1988-01-01

    This monograph is a review of the literature through 1987 and covers the methods of producing the radioisotopes of astatine and the inorganic, nuclear, and organic chemistry of astatine. The discussion is limited to chemical and physical chemical properties of astatine. The monograph, after the introduction, is divided into chapters titled: production methods, nuclear spectroscopy, chemistry of astatine, separation and isolation (dry and wet), and selected procedures. 209 refs., 15 figs., 7 tabs. (DLC)

  3. Radiochemistry of astatine

    SciTech Connect

    Ruth, T.J.; Dombsky, M.; D'Auria, J.M.; Ward, T.E.

    1988-01-01

    This monograph is a review of the literature through 1987 and covers the methods of producing the radioisotopes of astatine and the inorganic, nuclear, and organic chemistry of astatine. The discussion is limited to chemical and physical chemical properties of astatine. The monograph, after the introduction, is divided into chapters titled: production methods, nuclear spectroscopy, chemistry of astatine, separation and isolation (dry and wet), and selected procedures. 209 refs., 15 figs., 7 tabs. (DLC)

  4. Electrophilic addition of astatine

    SciTech Connect

    Norseev, Yu.V.; Vasaros, L.; Nhan, D.D.; Huan, N.K.

    1988-03-01

    It has been shown for the first time that astatine is capable of undergoing addition reactions to unsaturated hydrocarbons. A new compound of astatine, viz., ethylene astatohydrin, has been obtained, and its retention numbers of squalane, Apiezon, and tricresyl phosphate have been found. The influence of various factors on the formation of ethylene astatohydrin has been studied. It has been concluded on the basis of the results obtained that the univalent cations of astatine in an acidic medium is protonated hypoastatous acid.

  5. Preparation of astatine-labeled monoclonal antibodies

    SciTech Connect

    Milesz, S.; Norseev, Yu.V.; Szucs, Z. |

    1995-07-01

    In the cationic state astatine forms a stable complex with diethylenetriaminepentaacetic acid. Thanks to this complex, astatine can be bound to monoclonal antibodies of the RYa{sub 1} type. The most favorable conditions for preparing astatine-labeled antibodies are established. The chromatographic analysis and electromigration experiments showed that astatine is firmly linked to a biomolecule in vitro and it did not escape from labeled monoclonal antibodies even under treatment with such highly effective astatine-complexing agent as thiourea. The immune activity of astatine-labeled antibodies did not change even after 20 h.

  6. Radioiodinated and astatinated NHC rhodium complexes: synthesis.

    PubMed

    Rajerison, Holisoa; Guérard, François; Mougin-Degraef, Marie; Bourgeois, Mickael; Da Silva, Isidro; Chérel, Michel; Barbet, Jacques; Faivre-Chauvet, Alain; Gestin, Jean-François

    2014-05-01

    The clinical development of radioimmunotherapy with astatine-211 is limited by the lack of a stable radiolabeling method for antibody fragments. An astatinated N-heterocyclic carbene (NHC) Rhodium complex was assessed for the improvement of radiolabeling methodologies with astatine. Wet harvested astatine-211 in diisopropyl ether was used. Astatine was first reduced with cysteine then was reacted with a chlorinated Rh-NHC precursor to allow the formation of the astatinated analogue. Reaction conditions have been optimized. Astatine and iodine reactivity were also compared. Serum stability of the astatinated complex has been evaluated. Quantitative formation of astatide was observed when cysteine amounts higher than 46.2 nmol/μl of astatine solution were added. Nucleophilic substitution kinetics showed that high radiolabeling yields were obtained within 15 min at 60°C (88%) or within 5 min at 100°C (95%). Chromatographic characteristics of this new astatinated compound have been correlated with the cold iodinated analog ones. The radioiodinated complex was also synthesized from the same precursor (5 min. at 100°C, up to 85%) using [(125)I]NaI as a radiotracer. In vitro stability of the astatinated complex was controlled after 15 h incubation in human serum at 4°C and 37°C. No degradation was observed, indicating the good chemical and enzymatic stability. The astatinated complex was obtained in good yield and exhibited good chemical and enzymatic stability. These preliminary results demonstrate the interest of this new radiolabeling methodology, and further functionalizations should open new possibilities in astatine chemistry. Although there are many steps and pitfalls before clinical use for a new prosthetic group from the family of NHC complexes, this work may open a new path for astatine-211 targeting. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Condensed astatine: monatomic and metallic.

    PubMed

    Hermann, Andreas; Hoffmann, Roald; Ashcroft, N W

    2013-09-13

    The condensed matter properties of the nominal terminating element of the halogen group with atomic number 85, astatine, are as yet unknown. In the intervening more than 70 years since its discovery significant advances have been made in substrate cooling and the other techniques necessary for the production of the element to the point where we might now enquire about the key properties astatine might have if it attained a condensed phase. This subject is addressed here using density functional theory and structural selection methods, with an accounting for relativistic physics that is essential. Condensed astatine is predicted to be quite different in fascinating ways from iodine, being already at 1 atm a metal, and monatomic at that, and possibly a superconductor (as is dense iodine).

  8. Condensed Astatine: Monatomic and Metallic

    NASA Astrophysics Data System (ADS)

    Hermann, Andreas; Hoffmann, Roald; Ashcroft, N. W.

    2013-09-01

    The condensed matter properties of the nominal terminating element of the halogen group with atomic number 85, astatine, are as yet unknown. In the intervening more than 70 years since its discovery significant advances have been made in substrate cooling and the other techniques necessary for the production of the element to the point where we might now enquire about the key properties astatine might have if it attained a condensed phase. This subject is addressed here using density functional theory and structural selection methods, with an accounting for relativistic physics that is essential. Condensed astatine is predicted to be quite different in fascinating ways from iodine, being already at 1 atm a metal, and monatomic at that, and possibly a superconductor (as is dense iodine).

  9. Astatine Radiopharmaceuticals: Prospects and Problems.

    PubMed

    Vaidyanathan, Ganesan; Zalutsky, Michael R

    2008-09-01

    For the treatment of minimum residual diseases such micrometastases and residual tumor margins that remain after debulking of the primary tumor, targeted radiotherapy using radiopharmaceuticals tagged with alpha-particle-emitting radionuclides is very attractive. In addition to the their short range in tissue, which helps minimize harmful effects on adjacent normal tissues, alpha-particles, being high LET radiation, have several radiobiological advantages. The heavy halogen, astatine-211 is one of the prominent alpha-particle-emitting radionuclides in practice. Being a halogen, it can often be incorporated into biomolecules of interest by adapting radioiodination chemistry. A wide spectrum of compounds from the simple [(211)At]astatide ion to small organic molecules, peptides, and large proteins labeled with (211)At have been investigated with at least two reaching the stage of clinical evaluation. The chemistry, cytotoxic advantages, biodistribution studies, and microdosimetry/pharmacokinetic modeling of some of these agents will be reviewed. In addition, potential problems such as the harmful effect of radiolysis on the synthesis, lack of sufficient in vivo stability of astatinated compounds, and possible adverse effects when they are systemically administered will be discussed.

  10. Astatine Radiopharmaceuticals: Prospects and Problems

    PubMed Central

    Vaidyanathan, Ganesan; Zalutsky, Michael R.

    2010-01-01

    For the treatment of minimum residual diseases such micrometastases and residual tumor margins that remain after debulking of the primary tumor, targeted radiotherapy using radiopharmaceuticals tagged with α-particle-emitting radionuclides is very attractive. In addition to the their short range in tissue, which helps minimize harmful effects on adjacent normal tissues, α-particles, being high LET radiation, have several radiobiological advantages. The heavy halogen, astatine-211 is one of the prominent α-particle-emitting radionuclides in practice. Being a halogen, it can often be incorporated into biomolecules of interest by adapting radioiodination chemistry. A wide spectrum of compounds from the simple [211At]astatide ion to small organic molecules, peptides, and large proteins labeled with 211At have been investigated with at least two reaching the stage of clinical evaluation. The chemistry, cytotoxic advantages, biodistribution studies, and microdosimetry/pharmacokinetic modeling of some of these agents will be reviewed. In addition, potential problems such as the harmful effect of radiolysis on the synthesis, lack of sufficient in vivo stability of astatinated compounds, and possible adverse effects when they are systemically administered will be discussed. PMID:20150978

  11. Astatine and Yttrium Resonant Ionization Laser Spectroscopy

    NASA Astrophysics Data System (ADS)

    Teigelhoefer, Andrea

    Providing intense, contamination-free beams of rare isotopes to experiments is a challenging task. At isotope separator on-line facilities such as ISAC at TRIUMF, the choice of production target and ion source are key to the successful beam delivery. Due to their element-selectivity, high efficiency and versatility, resonant ionization laser ion sources (RILIS) gain increasingly in importance. The spectroscopic data available are typically incomplete in the region of excited- and autoionizing atomic states. In order to find the most efficient ionization scheme for a particular element, further spectroscopy is often required. The development of efficient laser resonant ionization schemes for yttrium and astatine is presented in this thesis. For yttrium, two ionization schemes with comparable relative intensities were found. Since for astatine, only two transitions were known, the focus was to provide data on atomic energy levels using resonance ionization spectroscopy. Altogether 41 previously unknown astatine energy levels were found.

  12. Astatine-211: Production and Availability

    PubMed Central

    Zalutsky, Michael R.; Pruszynski, Marek

    2012-01-01

    The 7.2-h half life radiohalogen 211At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the 209Bi( α,2n)211At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of 210At, which is problematic because of its 138.4-day half life α-particle emitting daughter, 210Po. The intrinsic cost for producing 211At is reasonably modest and comparable to that of commercially available 123I. The major impediment to 211At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for 211At production. PMID:22201707

  13. Astatine-211: production and availability.

    PubMed

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production.

  14. Establishment of an European Astatine Collaboration

    SciTech Connect

    Weinreich, R. |

    1994-12-31

    {sup 211}At is an extremely radiotoxic nuclide. It decays with a half-life of 7.2 hrs by emission of (on average) one {alpha}-particle and a number of Auger and Coster-Kronig electrons per decay. The maximum range of the a-particles is 80 {mu}m, consequently a few cell diameters. In the last years, the general interest in astatine labelled compounds for radionuclide therapy has been reinforced: studies of the radiobiological behaviour of {sup 211}At in cell culture-experiments confirmed clearly its usefulness for radiotherapeutic applications. Astatine compounds have been found which are relatively stable and useful as linkers between the nuclide and carrier proteins. A clinical study using {sup 211}At-Methylene blue as radiotoxic substance as well as tumour-seeking ligand is now under consideration. On the other hand, the low availability of the nuclide is still the most important limitation for a broader clinical application: for production of this nuclide, {alpha}-particles of 28 MeV are needed. These particles are mostly generated in medium-energy multi-particle accelerators of variable energy. Such accelerators, however, are generally used by different research groups with different research aims and consequently different beamtime modes.

  15. Production and separation of Astatine Radionuclides: some new addition to Astatine Chemistry.

    PubMed

    Roy, Kamalika; Lahiri, Susanta

    2008-05-01

    For the first time no-carrier-added (nca) (209,210)At radionuclides were produced by heavy ion ((7)Li) activation from 4 mg/cm(2) lead nitrate target. Astatine was separated from the bulk target by three different approaches. Nca astatine radionuclide was selectively partitioned in the (i) polymer rich phase of an aqueous biphasic system consisting of polyethylene glycol (PEG) 4000 (50% w/w) and 2M Na(2)SO(4) solution (ii) aqueous phase of a liquid liquid extraction system being comprised of a liquid cation exchanger, HDEHP (di-2-ethylhexyl phosphoric acid) (0.5%) and liquor ammonia (iii) liquid phase of a solid liquid extraction system of cation exchange resin Dowex-50 and 10(-6)M HCl. Very high separation factors have been achieved in all the three methods.

  16. Discovery of the astatine, radon, francium, and radium isotopes

    NASA Astrophysics Data System (ADS)

    Fry, C.; Thoennessen, M.

    2013-09-01

    Thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is described. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  17. Discovery of the astatine, radon, francium, and radium isotopes

    SciTech Connect

    Fry, C.; Thoennessen, M.

    2013-09-15

    Thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is described. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  18. Process for producing astatine-211 for radiopharmaceutical use

    DOEpatents

    Mirzadeh, S.; Lambrecht, R.M.

    1984-04-10

    A process is described for reliably and consistently producing astatine-211 in small controlled volumes of a solution, which is selected from a choice of solvents that are useful in selected radiopharmaceutical procedures in which the At-211 activities are to be applied. 4 figures, 1 table.

  19. Process for producing astatine-211 for radiopharmaceutical use

    DOEpatents

    Mirzadeh, Saed; Lambrecht, Richard M.

    1987-01-01

    A process for reliably and consistently producing astatine-211 in small controlled volumes of a solution, which is selected from a choice of solvents that are useful in selected radiopharmaceutical procedures in which the At-211 activities are to be applied.

  20. Incorporation of thiosemicarbazide in Amberlite IRC-50 for separation of astatine from alpha-irradiated bismuth oxide.

    PubMed

    Roy, Kamalika; Basu, S; Ramaswami, A; Nayak, Dalia; Lahiri, Susanta

    2004-06-01

    A chelating resin was synthesized by incorporating thiosemicarbazide into Amberlite IRC-50, a weakly acidic polymer. Astatine radionuclides produced by alpha-irradiating bismuth oxide were separated using the newly synthesized chelating resin. The resin showed high selectivity for astatine. The adsorbed astatine was recovered using 0.1M EDTA at pH approximately 10.

  1. Delayed and In-beam Spectroscopy on Francium and Astatine Nuclei at the Proton Drip Line

    NASA Astrophysics Data System (ADS)

    Uusitalo, J.; Jakobsson, U.

    2011-11-01

    Delayed and in-beam spectroscopy on francium and astatine nuclei at and beyond the proton drip line has been performed. In neutron deficient astatine nuclei a shift to deformed shapes as a function of decreasing neutron has been obtained. In neutron deficient francium isotope the same shift is evident.

  2. Delayed and In-beam Spectroscopy on Francium and Astatine Nuclei at the Proton Drip Line

    SciTech Connect

    Uusitalo, J.; Jakobsson, U.; Collaboration: RITU-Gamma Gollaboration

    2011-11-30

    Delayed and in-beam spectroscopy on francium and astatine nuclei at and beyond the proton drip line has been performed. In neutron deficient astatine nuclei a shift to deformed shapes as a function of decreasing neutron has been obtained. In neutron deficient francium isotope the same shift is evident.

  3. Graphs for Isotopes of 85-At(Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 85-At (Astatine, atomic number Z = 85).

  4. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    PubMed Central

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Köster, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjödin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.31751(8) eV. New ab initio calculations are performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of superheavy element 117, the heaviest homologue of astatine. PMID:23673620

  5. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NASA Astrophysics Data System (ADS)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; de Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Köster, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjödin, A. M.; van den Bergh, P.; van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    2013-05-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.31751(8) eV. New ab initio calculations are performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of superheavy element 117, the heaviest homologue of astatine.

  6. Measurement of the first ionization potential of astatine by laser ionization spectroscopy.

    PubMed

    Rothe, S; Andreyev, A N; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yuri; Köster, U; Lane, J F W; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt, K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.31751(8) eV. New ab initio calculations are performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of superheavy element 117, the heaviest homologue of astatine.

  7. Scrutinizing "Invisible" astatine: A challenge for modern density functionals.

    PubMed

    Sergentu, Dumitru-Claudiu; David, Grégoire; Montavon, Gilles; Maurice, Rémi; Galland, Nicolas

    2016-06-05

    The main-group 6p elements did not receive much attention in the development of recent density functionals. In many cases it is still difficult to choose among the modern ones a relevant functional for various applications. Here, we illustrate the case of astatine species (At, Z = 85) and we report the first, and quite complete, benchmark study on several properties concerning such species. Insights on geometries, transition energies and thermodynamic properties of a set of 19 astatine species, for which reference experimental or theoretical data has been reported, are obtained with relativistic (two-component) density functional theory calculations. An extensive set of widely used functionals is employed. The hybrid meta-generalized gradient approximation (meta-GGA) PW6B95 functional is overall the best choice. It is worth noting that the range-separated HSE06 functional as well as the old and very popular B3LYP and PBE0 hybrid-GGAs appear to perform quite well too. Moreover, we found that astatine chemistry in solution can accurately be predicted using implicit solvent models, provided that specific parameters are used to build At cavities. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  8. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    PubMed

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies.

  9. Atomic Mass and Nuclear Binding Energy for At-283 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-283 (Astatine, atomic number Z = 85, mass number A = 283).

  10. Atomic Mass and Nuclear Binding Energy for At-280 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-280 (Astatine, atomic number Z = 85, mass number A = 280).

  11. Atomic Mass and Nuclear Binding Energy for At-284 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-284 (Astatine, atomic number Z = 85, mass number A = 284).

  12. Atomic Mass and Nuclear Binding Energy for At-245 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-245 (Astatine, atomic number Z = 85, mass number A = 245).

  13. Atomic Mass and Nuclear Binding Energy for At-217 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-217 (Astatine, atomic number Z = 85, mass number A = 217).

  14. Atomic Mass and Nuclear Binding Energy for At-221 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-221 (Astatine, atomic number Z = 85, mass number A = 221).

  15. Atomic Mass and Nuclear Binding Energy for At-266 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-266 (Astatine, atomic number Z = 85, mass number A = 266).

  16. Atomic Mass and Nuclear Binding Energy for At-237 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-237 (Astatine, atomic number Z = 85, mass number A = 237).

  17. Atomic Mass and Nuclear Binding Energy for At-248 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-248 (Astatine, atomic number Z = 85, mass number A = 248).

  18. Atomic Mass and Nuclear Binding Energy for At-225 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-225 (Astatine, atomic number Z = 85, mass number A = 225).

  19. Atomic Mass and Nuclear Binding Energy for At-270 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-270 (Astatine, atomic number Z = 85, mass number A = 270).

  20. Atomic Mass and Nuclear Binding Energy for At-228 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-228 (Astatine, atomic number Z = 85, mass number A = 228).

  1. Atomic Mass and Nuclear Binding Energy for At-226 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-226 (Astatine, atomic number Z = 85, mass number A = 226).

  2. Atomic Mass and Nuclear Binding Energy for At-252 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-252 (Astatine, atomic number Z = 85, mass number A = 252).

  3. Atomic Mass and Nuclear Binding Energy for At-267 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-267 (Astatine, atomic number Z = 85, mass number A = 267).

  4. Atomic Mass and Nuclear Binding Energy for At-259 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-259 (Astatine, atomic number Z = 85, mass number A = 259).

  5. Atomic Mass and Nuclear Binding Energy for At-238 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-238 (Astatine, atomic number Z = 85, mass number A = 238).

  6. Atomic Mass and Nuclear Binding Energy for At-235 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-235 (Astatine, atomic number Z = 85, mass number A = 235).

  7. Atomic Mass and Nuclear Binding Energy for At-265 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-265 (Astatine, atomic number Z = 85, mass number A = 265).

  8. Atomic Mass and Nuclear Binding Energy for At-239 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-239 (Astatine, atomic number Z = 85, mass number A = 239).

  9. Atomic Mass and Nuclear Binding Energy for At-243 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-243 (Astatine, atomic number Z = 85, mass number A = 243).

  10. Atomic Mass and Nuclear Binding Energy for At-242 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-242 (Astatine, atomic number Z = 85, mass number A = 242).

  11. Atomic Mass and Nuclear Binding Energy for At-246 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-246 (Astatine, atomic number Z = 85, mass number A = 246).

  12. Atomic Mass and Nuclear Binding Energy for At-231 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-231 (Astatine, atomic number Z = 85, mass number A = 231).

  13. Atomic Mass and Nuclear Binding Energy for At-255 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-255 (Astatine, atomic number Z = 85, mass number A = 255).

  14. Atomic Mass and Nuclear Binding Energy for At-262 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-262 (Astatine, atomic number Z = 85, mass number A = 262).

  15. Atomic Mass and Nuclear Binding Energy for At-258 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-258 (Astatine, atomic number Z = 85, mass number A = 258).

  16. Atomic Mass and Nuclear Binding Energy for At-249 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-249 (Astatine, atomic number Z = 85, mass number A = 249).

  17. Atomic Mass and Nuclear Binding Energy for At-256 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-256 (Astatine, atomic number Z = 85, mass number A = 256).

  18. Atomic Mass and Nuclear Binding Energy for At-274 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-274 (Astatine, atomic number Z = 85, mass number A = 274).

  19. Atomic Mass and Nuclear Binding Energy for At-250 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-250 (Astatine, atomic number Z = 85, mass number A = 250).

  20. Atomic Mass and Nuclear Binding Energy for At-247 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-247 (Astatine, atomic number Z = 85, mass number A = 247).

  1. Atomic Mass and Nuclear Binding Energy for At-269 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-269 (Astatine, atomic number Z = 85, mass number A = 269).

  2. Atomic Mass and Nuclear Binding Energy for At-216 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-216 (Astatine, atomic number Z = 85, mass number A = 216).

  3. Atomic Mass and Nuclear Binding Energy for At-236 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-236 (Astatine, atomic number Z = 85, mass number A = 236).

  4. Atomic Mass and Nuclear Binding Energy for At-276 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-276 (Astatine, atomic number Z = 85, mass number A = 276).

  5. Atomic Mass and Nuclear Binding Energy for At-244 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-244 (Astatine, atomic number Z = 85, mass number A = 244).

  6. Atomic Mass and Nuclear Binding Energy for At-234 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-234 (Astatine, atomic number Z = 85, mass number A = 234).

  7. Atomic Mass and Nuclear Binding Energy for At-271 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-271 (Astatine, atomic number Z = 85, mass number A = 271).

  8. Atomic Mass and Nuclear Binding Energy for At-282 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-282 (Astatine, atomic number Z = 85, mass number A = 282).

  9. Atomic Mass and Nuclear Binding Energy for At-253 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-253 (Astatine, atomic number Z = 85, mass number A = 253).

  10. Atomic Mass and Nuclear Binding Energy for At-264 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-264 (Astatine, atomic number Z = 85, mass number A = 264).

  11. Atomic Mass and Nuclear Binding Energy for At-251 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-251 (Astatine, atomic number Z = 85, mass number A = 251).

  12. Atomic Mass and Nuclear Binding Energy for At-275 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-275 (Astatine, atomic number Z = 85, mass number A = 275).

  13. Atomic Mass and Nuclear Binding Energy for At-224 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-224 (Astatine, atomic number Z = 85, mass number A = 224).

  14. Atomic Mass and Nuclear Binding Energy for At-233 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-233 (Astatine, atomic number Z = 85, mass number A = 233).

  15. Atomic Mass and Nuclear Binding Energy for At-219 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-219 (Astatine, atomic number Z = 85, mass number A = 219).

  16. Atomic Mass and Nuclear Binding Energy for At-277 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-277 (Astatine, atomic number Z = 85, mass number A = 277).

  17. Atomic Mass and Nuclear Binding Energy for At-229 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-229 (Astatine, atomic number Z = 85, mass number A = 229).

  18. Atomic Mass and Nuclear Binding Energy for At-261 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-261 (Astatine, atomic number Z = 85, mass number A = 261).

  19. Atomic Mass and Nuclear Binding Energy for At-279 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-279 (Astatine, atomic number Z = 85, mass number A = 279).

  20. Atomic Mass and Nuclear Binding Energy for At-268 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-268 (Astatine, atomic number Z = 85, mass number A = 268).

  1. Atomic Mass and Nuclear Binding Energy for At-263 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-263 (Astatine, atomic number Z = 85, mass number A = 263).

  2. Atomic Mass and Nuclear Binding Energy for At-232 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-232 (Astatine, atomic number Z = 85, mass number A = 232).

  3. Atomic Mass and Nuclear Binding Energy for At-220 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-220 (Astatine, atomic number Z = 85, mass number A = 220).

  4. Atomic Mass and Nuclear Binding Energy for At-223 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-223 (Astatine, atomic number Z = 85, mass number A = 223).

  5. Atomic Mass and Nuclear Binding Energy for At-222 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-222 (Astatine, atomic number Z = 85, mass number A = 222).

  6. Atomic Mass and Nuclear Binding Energy for At-241 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-241 (Astatine, atomic number Z = 85, mass number A = 241).

  7. Atomic Mass and Nuclear Binding Energy for At-272 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-272 (Astatine, atomic number Z = 85, mass number A = 272).

  8. Atomic Mass and Nuclear Binding Energy for At-240 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-240 (Astatine, atomic number Z = 85, mass number A = 240).

  9. Atomic Mass and Nuclear Binding Energy for At-273 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-273 (Astatine, atomic number Z = 85, mass number A = 273).

  10. Atomic Mass and Nuclear Binding Energy for At-257 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-257 (Astatine, atomic number Z = 85, mass number A = 257).

  11. Atomic Mass and Nuclear Binding Energy for At-227 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-227 (Astatine, atomic number Z = 85, mass number A = 227).

  12. Atomic Mass and Nuclear Binding Energy for At-285 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-285 (Astatine, atomic number Z = 85, mass number A = 285).

  13. Atomic Mass and Nuclear Binding Energy for At-278 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-278 (Astatine, atomic number Z = 85, mass number A = 278).

  14. Atomic Mass and Nuclear Binding Energy for At-281 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-281 (Astatine, atomic number Z = 85, mass number A = 281).

  15. Atomic Mass and Nuclear Binding Energy for At-254 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-254 (Astatine, atomic number Z = 85, mass number A = 254).

  16. Atomic Mass and Nuclear Binding Energy for At-230 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-230 (Astatine, atomic number Z = 85, mass number A = 230).

  17. Atomic Mass and Nuclear Binding Energy for At-260 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-260 (Astatine, atomic number Z = 85, mass number A = 260).

  18. Astatine-211-tellurium radiocolloid cures experimental malignant ascites

    SciTech Connect

    Bloomer, W.D.; McLaughlin, W.H.; Neirinckx, R.D.; Adelstein, S.J.; Gordon, P.R.; Ruth, T.J.; Wolf, A.P.

    1981-04-17

    An investigation of the efficacy of astatine-211-tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this ..cap alpha..-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with ..cap alpha..-emission. These results have important implications for the development and use of ..cap alpha..-emitters as radiocolloid therapy for the treatment of human tumors.

  19. Atomic Mass and Nuclear Binding Energy for At-214 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-214 (Astatine, atomic number Z = 85, mass number A = 214).

  20. Atomic Mass and Nuclear Binding Energy for At-215 (Astatine)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope At-215 (Astatine, atomic number Z = 85, mass number A = 215).

  1. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    NASA Astrophysics Data System (ADS)

    Jakobsson, U.; Uusitalo, J.; Auranen, K.; Badran, H.; Cederwall, B.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; HerzáÅ, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J.; Scholey, C.; Sorri, J.; Stolze, S.

    2015-10-01

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2+ state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2+ state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2+ state and the spherical 9/2- ground state in 203Fr and 205Fr.

  2. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    SciTech Connect

    Jakobsson, U. Cederwall, B.; Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J.; and others

    2015-10-15

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  3. Automated astatination of biomolecules--a stepping stone towards multicenter clinical trials.

    PubMed

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-07-14

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method that combines dry distillation of astatine-211 and a synthesis module for producing radiopharmaceuticals into a process platform. This platform will standardize production of astatinated radiopharmaceuticals, and hence, it will facilitate large clinical studies focused on this promising, but chemically challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies.

  4. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    NASA Astrophysics Data System (ADS)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-07-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method that combines dry distillation of astatine-211 and a synthesis module for producing radiopharmaceuticals into a process platform. This platform will standardize production of astatinated radiopharmaceuticals, and hence, it will facilitate large clinical studies focused on this promising, but chemically challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies.

  5. Automated astatination of biomolecules – a stepping stone towards multicenter clinical trials

    PubMed Central

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method that combines dry distillation of astatine-211 and a synthesis module for producing radiopharmaceuticals into a process platform. This platform will standardize production of astatinated radiopharmaceuticals, and hence, it will facilitate large clinical studies focused on this promising, but chemically challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies. PMID:26169786

  6. Astatinated trastuzumab, a putative agent for radionuclide immunotherapy of ErbB2-expressing tumours.

    PubMed

    Persson, M I; Gedda, L; Jensen, H J; Lundqvist, H; Malmström, P-U; Tolmachev, V

    2006-03-01

    The anti-ErbB2 antibody trastuzumab is used for the treatment of patients with advanced breast cancer, resulting in a response rate of 40-60%. Coupling with a cytotoxic nuclide, e.g. alpha-emitting 211At, may further increase tumour response. The tumour-targeting properties of trastuzumab, astatinated using N-succinimidyl-para-(tri-n-methylstannyl)-benzoate, were evaluated and compared with those of radioiodinated trastuzumab in this study. We found that astatinated trastuzumab retains high specificity towards ErbB2. While the immunoreactive fraction of radioiodinated trastuzumab was higher than that of astatinated trastuzumab (76+/-9% versus 54+/-28%), both radioconjugates showed high affinity (KD 0.75+/-0.16 nM versus 1.8+/-0.3 nM). A growth inhibition study indicated a dose-dependent cell deactivation, in which approximately 74 cell-associated astatine decays per cell gave a survival fraction of 4.5+/-0.8x10(-4). Results of a comparative animal study on normal mice gave no indication that astatination would have any adverse effects on the biodistribution of the antibody. In conclusion, the results of the study suggest that astatinated trastuzumab is a promising candidate for treating ErbB2-expressing tumours.

  7. Theoretical approach to explore the production routes of astatine radionuclides

    SciTech Connect

    Maiti, Moumita; Lahiri, Susanta

    2009-02-15

    To fulfill the recent thrust of astatine radionuclides in the field of nuclear medicine, various production routes have been explored in the present work. The possible production routes of {sup 209-211}At comprise both light- and heavy-ion-induced reactions at the bombarding energy range starting from threshold to a maximum of 100 MeV. Excitation functions of those radionuclides, produced through various production routes, have been calculated by using nuclear reaction model codes TALYS, ALICE91, and PACE-II and are compared with the available measured data. Contributions of various reaction mechanisms, such as direct, pre-equilibrium, and equilibrium reactions, to the total reaction cross section have been studied using the codes. Results show that the equilibrium reaction dominates in all cases over other reaction mechanisms.

  8. Theoretical approach to explore the production routes of astatine radionuclides

    NASA Astrophysics Data System (ADS)

    Maiti, Moumita; Lahiri, Susanta

    2009-02-01

    To fulfill the recent thrust of astatine radionuclides in the field of nuclear medicine, various production routes have been explored in the present work. The possible production routes of At209-211 comprise both light- and heavy-ion-induced reactions at the bombarding energy range starting from threshold to a maximum of 100 MeV. Excitation functions of those radionuclides, produced through various production routes, have been calculated by using nuclear reaction model codes TALYS, ALICE91, and PACE-II and are compared with the available measured data. Contributions of various reaction mechanisms, such as direct, pre-equilibrium, and equilibrium reactions, to the total reaction cross section have been studied using the codes. Results show that the equilibrium reaction dominates in all cases over other reaction mechanisms.

  9. Modeling astatine production in liquid lead-bismuth spallation targets

    NASA Astrophysics Data System (ADS)

    David, J. C.; Boudard, A.; Cugnon, J.; Ghali, S.; Leray, S.; Mancusi, D.; Zanini, L.

    2013-03-01

    Astatine isotopes can be produced in liquid lead-bismuth eutectic targets through proton-induced double charge exchange reactions on bismuth or in secondary helium-induced interactions. Models implemented into the most common high-energy transport codes generally have difficulties to correctly estimate their production yields as was shown recently by the ISOLDE Collaboration, which measured release rates from a lead-bismuth target irradiated by 1.4 and 1 GeV protons. In this paper, we first study the capability of the new version of the Liège intranuclear cascade model, INCL4.6, coupled to the deexcitation code ABLA07 to predict the different elementary reactions involved in the production of such isotopes through a detailed comparison of the model with the available experimental data from the literature. Although a few remaining deficiencies are identified, very satisfactory results are found, thanks in particular to improvements brought recently on the treatment of low-energy helium-induced reactions. The implementation of the models into MCNPX allows identifying the respective contributions of the different possible reaction channels in the ISOLDE case. Finally, the full simulation of the ISOLDE experiment is performed, taking into account the likely rather long diffusion time from the target, and compared with the measured diffusion rates for the different astatine isotopes, at the two studied energies, 1.4 and 1 GeV. The shape of the isotopic distribution is perfectly reproduced as well as the absolute release rates, assuming in the calculation a diffusion time between 5 and 10hours. This work finally shows that our model, thanks to the attention paid to the emission of high-energy clusters and to low-energy cluster induced reactions, can be safely used within MCNPX to predict isotopes with a charge larger than that of the target by two units in spallation targets, and, probably, more generally to isotopes created in secondary reactions induced by composite

  10. Assessment of an effective quasirelativistic methodology designed to study astatine chemistry in aqueous solution.

    PubMed

    Champion, Julie; Seydou, Mahamadou; Sabatié-Gogova, Andrea; Renault, Eric; Montavon, Gilles; Galland, Nicolas

    2011-09-07

    A cost-effective computational methodology designed to study astatine (At) chemistry in aqueous solution has been established. It is based on two-component spin-orbit density functional theory calculations and solvation calculations using the conductor-like polarizable continuum model in conjunction with specific astatine cavities. Theoretical calculations are confronted with experimental data measured for complexation reactions between metallic forms of astatine (At(+) and AtO(+)) and inorganic ligands (Cl(-), Br(-) and SCN(-)). For each reaction, both 1:1 and 1:2 complexes are evidenced. The experimental trends regarding the thermodynamic constants (K) can be reproduced qualitatively and quantitatively. The mean signed error on computed Log K values is -0.4, which corresponds to a mean signed error smaller than 1 kcal mol(-1) on free energies of reaction. Theoretical investigations show that the reactivity of cationic species of astatine is highly sensitive to spin-orbit coupling and solvent effects. At the moment, the presented computational methodology appears to be the only tool to gain an insight into astatine chemistry at a molecular level. This journal is © the Owner Societies 2011

  11. Targeting against epidermal growth factor receptors. Cellular processing of astatinated EGF after binding to cultured carcinoma cells.

    PubMed

    Orlova, Anna; Sjöstrom, Anna; Lebeda, Ondrej; Lundqvist, Hans; Carlsson, Jorgen; Tolmachev, Vladimir

    2004-01-01

    The alpha-emitting nuclide 211At is of great interest for radionuclide therapy when coupled to a tumor-targeting biomolecule, e.g. epidermal growth factor (EGF) the receptors of which are overexpressed in many malignancies. However, almost no information concerning the cellular processing of astatinated targeting agents is available. We indirectly astatinated EGF ([211At]-benzoate-EGF) and studied its cellular processing in A-431 carcinoma cells in comparison with data concerning [125I]-benzoate-EGF. The biological half-life of astatine (3.5 h) was longer than the half-life of the iodine label (1.5 h). The increase of the half-life was due to longer retention of the internalised astatine radioactivity. The maximum accumulation for the astatine label occurred later (4-6h) than that for the iodine label (2-4h), indicating a slower excretion of astatine that was confirmed in experiment with 211At/1251-benzoate-EGF. The long retention of astatine might be advantageous for radionuclide therapy.

  12. Reagents for astatination of biomolecules: comparison of the in vivo distribution and stability of some radioiodinated/astatinated benzamidyl and nido-carboranyl compounds.

    PubMed

    Wilbur, D Scott; Chyan, Ming-Kuan; Hamlin, Donald K; Kegley, Brian B; Risler, Reudi; Pathare, Pradip M; Quinn, Janna; Vessella, Robert L; Foulon, Catherine; Zalutsky, Michael; Wedge, Timothy J; Hawthorne, M Frederick

    2004-01-01

    An investigation has been conducted to assess the in vivo stability of a series of astatinated benzamides and astatinated nido-carborane compounds in mice. It was hypothesized that the higher bond strength of boron-astatine bonds in the nido-carboranes might provide increased stability toward in vivo deastatination. Four tri-n-butylstannylbenzamides were prepared for radiohalogenation and evaluation in vivo. Those compounds were N-propyl-4-(tri-n-butylstannyl)benzamide 1a, N-propyl-3-(tri-n-butylstannyl)benzamide 2a, ethyl 4-tri-n-butylstannylhippurate 3a, and 4-tri-n-butylstannyl-hippuric acid 4a. Seven mono-nido-carboranyl derivatives were prepared for radiohalogenation and in vivo evaluation. Four of the seven mono-carboranyl derivatives (5a, 6a, 7a, 13a) contained a 3-(nido-carboranyl)propionamide functionality, and the remaining compounds (8a, 8g, 10a) contained a 4-(nido-carboranyl)aniline functionality. Two additional derivatives (11a, 12a) were prepared that contained bis-(nido-carboranylmethyl)benzene moieties (also referred to as Venus flytrap complexes (VFCs). All benzamide and nido-carborane compounds underwent facile iodination and radiohalogenation, except a 4-(nido-carboranyl)aniline derivative, 8a. Iodination of 8a resulted in a mixture, of which the desired iodinated product was a minor component. Therefore, radiohalogenation was not attempted. It is believed that the mixture of products is due to the presence of a thiourea bond. Previous studies have shown that thiourea bonds can interfere with halogenation reactions. In vivo comparisons of the compounds were conducted by co-injection of dual labeled (125/131I and 211At) compounds. Tissue distribution data were obtained at 1 and 4 h postinjection of the radiolabeled compounds, as that was sufficient to determine if astatine was being released. Stability of the astatinated compound was assessed by the difference in concentration of radioiodine and astatine in lung and spleen. All of the benzamides

  13. Astatine standard redox potentials and speciation in acidic medium.

    PubMed

    Champion, J; Alliot, C; Renault, E; Mokili, B M; Chérel, M; Galland, N; Montavon, G

    2010-01-14

    A combined experimental and theoretical approach is used to define astatine (At) speciation in acidic aqueous solution and to answer the two main questions raised from literature data: does At(0) exist in aqueous solution and what is the chemical form of At(+III), if it exists. The experimental approach considers that a given species is characterized by its distribution coefficient (D) experimentally determined in a biphasic system. The change in speciation arising from a change in experimental conditions is observed by a change in D value. The theoretical approach involves quasi-relativistic quantum chemistry calculations. The results show that At at the oxidation state 0 cannot exist in aqueous solution. The three oxidation states present in the range of water stability are At(-I), At(+I), and At(+III) and exist as At(-), At(+), and AtO(+), respectively, in the 1-2 pH range. The standard redox potentials of the At(+)/At(-) and AtO(+)/At(+) couples have been determined, the respective values being 0.36 +/- 0.01 and 0.74 +/- 0.01 V vs NHE.

  14. Microdosimetric model of astatine-211 labeled antibodies for radioimmunotherapy

    SciTech Connect

    Humm, J.L.

    1987-11-01

    Astatine-211 is an alpha-emitter with a short half-life (7.2 hr). This paper discusses the potential of /sup 211/At targeted by antibodies for tumor therapy and the possible advantage of /sup 211/At over beta- and gamma-emitting radionuclides such as /sup 131/I currently employed in the field of radioimmunotherapy. Since the longest range alpha-particle from /sup 211/At is only 67 microns and the rate of energy loss is high (track averaged linear energy transfer LT approximately 120 keV/micron), a disintegration of /sup 211/At produces a large and extremely localized deposition of energy. A Monte-Carlo model has been developed for studying the stochastic fluctuation of alpha-particle hits and energy deposition in cell nuclei in an attempt to determine the efficacy of /sup 211/At-labeled antibodies for tumor cell inactivation. Calculations have been performed for 2 extreme conditions: (a) the case of /sup 211/At retained in the capillary, and (b) for a homogeneous distribution of /sup 211/At-labeled antibody in the tumor. The results of these two calculations represent the boundary conditions between which any real solution must lie. Finally, developments to the model to include antibody transport across the capillary membrane and through the tumor tissue are discussed.

  15. Feasibility of the radioastatination of a monoclonal antibody with astatine-211 purified by wet extraction.

    PubMed

    Bourgeois, Mickaël; Guerard, François; Alliot, Cyrille; Mougin-Degraef, Marie; Rajérison, Holisoa; Remaud-Le Saëc, Patricia; Gestin, Jean-François; Davodeau, François; Chérel, Michel; Barbet, Jacques; Faivre-Chauvet, Alain

    2008-10-15

    Astatine-211, a most promising α-particle emitter for targeted radiotherapy, is generally obtained by high-temperature distillation. However, a liquid-liquid extraction procedure (wet extraction) has also been described. The purpose of this study was to develop and optimize the labelling of the stannylated-activated ester N-hydroxysuccinimidyl-meta-trimethylstannylbenzoate ester (MeSTB) with astatine-211 extracted in di-isopropylether (DIPE) in the presence of the oxidant N-chlorosuccinimide (NCS). The effect of final volume, incubation duration and NCS amounts on radiolabelling yield was studied. The best yields (85-90%) of N-hydroxysuccinimidyl-meta-[(211)At]astatobenzoate ester (SAB) were obtained with 20 nmol of MeSTB, 100 nmol of NCS in 120 µL of DIPE after 15 min. The astatine-211-labelled-activated ester was then used to radiolabel a monoclonal antibody (mAb). The labelling yield was 20-25% and the radiochemical purity was 97-99%. These results show that mAbs may be efficiently labelled with astatine-211 obtained by wet extraction, a fully automatable technique that may prove to be a useful alternative to dry distillation for high activity labelling of radiopharmaceuticals. Copyright © 2008 John Wiley & Sons, Ltd. Copyright © 2008 John Wiley & Sons, Ltd.

  16. Dry-distillation of astatine-211 from irradiated bismuth targets: a time-saving procedure with high recovery yields.

    PubMed

    Lindegren, S; Bäck, T; Jensen, H J

    2001-08-01

    Astatine-211 was produced via the 209Bi(alpha,2n) 211At reaction. The radionuclide was isolated with a novel procedure employing dry-distillation of the irradiated target material. The astatine was condensed as a dry residue in a PEEK-capillary cryotrap. Distillation was completed within 1-2 min with isolation yields of 92 +/- 3%. Subsequent work-up of the nuclide resulted in final recovery yields of 79 +/- 3%.

  17. Method for the simultaneous preparation of Radon-211, Xenon-125, Xenon-123, Astatine-211, Iodine-125 and Iodine-123

    DOEpatents

    Mirzadeh, Saed; Lambrecht, Richard M.

    1987-01-01

    A method for simultaneously preparing Radon-211, Astatine-211, Xenon-125, Xenon-123, Iodine-125 and Iodine-123 in a process that includes irradiating a fertile metal material then using a one-step chemical procedure to collect a first mixture of about equal amounts of Radon-211 and Xenon-125, and a separate second mixture of about equal amounts of Iodine-123 and Astatine-211.

  18. Nuclear Data Sheets for A = 218

    SciTech Connect

    Jain, Ashok K.; Singh, Balraj

    2006-04-15

    Nuclear spectroscopic information for known nuclides of mass number 218 (Bi,Po,At,Rn,Fr,Ra,Ac,Th,Pa,U) with Z = 83 to 92 and N = 135 to 126 have been evaluated and presented together with adopted energies and J{pi} of levels in these nuclei. No excited state data are yet available for {sup 218}Bi, {sup 218}At and {sup 218}Pa. Octupole structures are known in {sup 218}Rn, {sup 218}Fr, {sup 218}Ra and {sup 218}Ac nuclides. Since the previous update (1995El08) about ten years ago, many new data are available e.g. decays of {sup 218}Bi to {sup 218}Po, {sup 222}Ra to {sup 218}Rn and {sup 222}Th to {sup 218}Ra; high-spin structures in {sup 218}Rn and {sup 218}Fr; and lifetimes of excited states in {sup 218}Ra. This evaluation supersedes previous full evaluations of A = 218 published by 1987El12 and 1977To13; and an interim evaluation published in 'update' mode by 1995El08 with literature cutoff date of August 1995.

  19. In-source spectroscopy on astatine and radium for resonant laser ionization

    NASA Astrophysics Data System (ADS)

    Raeder, Sebastian; Lassen, Jens; Heggen, Henning; Teigelhöfer, Andrea

    2014-06-01

    At on-line isotope separator facilities, rare isotopes of radioactive elements such as astatine, radium or polonium are demanded for fundamental research on nuclear structure. These elements are generally suitable for a resonance ionization laser ion source, but more data on the atomic structure is necessary to develop efficient laser ionization schemes. Due to the missing stable reference isotopes spectroscopic investigation of the atomic structure can only be performed during on-line operation. At the Isotope Separator and ACcelerator (ISAC) facility at TRIUMF, the elements astatine and radium were investigated by in-source laser spectroscopy to optimize the laser ionization efficiency. For astatine, laser spectroscopy was performed to search for high lying bound states as well as for auto-ionizing resonances. This led to the identification of four new high lying bound states of odd parity, while no auto-ionizing resonances were observed in the investigated region. Furthermore, the feasibility and the impact of laser ionization on the yield of radium isotopes was investigated using an activated target after proton irradiation.

  20. 50 CFR 218.3 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Marine Mammals Incidental to U.S. Navy Training in the Virginia Capes Range Complex (VACAPES Range Complex) § 218.3 Prohibitions. Notwithstanding takings contemplated in § 218.2 and authorized by a...

  1. Environmental neutralization of polonium-218

    SciTech Connect

    Goldstein, S.D.; Hopke, P.K.

    1985-01-01

    Previous work has indicated that two mechanisms of neutralization of the singly charged polonium ion exist. Charged Polonium-218 can be neutralized by reacting with oxygen to form a polonium oxide ion with a higher ionization potential than that of the polonium metal and then accepting an electron transferred from a lower ionization potential gas. In this present work, this mechanism has been verified by determining that the polonium oxide has an ionization potential in the range 10.35-10.53 eV. It was also previously reported that /sup 218/Po can be neutralized, in the absence of oxygen, by the scavenging of electrons by a trace gas such as water or nitrogen dioxide and their diffusion to the polonium ion. To verify this second neutralization mechanism, concentrations of nitrogen dioxide in nitrogen in the range of 50 ppb-1 ppm were examined for their ability to neutralize the polonium ion. Complete neutralization of /sup 218/Po was observed at nitrogen dioxide concentrations greater than 700 ppb. For concentrations below 700 ppb, the degree of neutralization was found to increase smoothly with the nitrogen dioxide concentration.

  2. 20 CFR 498.218 - The record.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false The record. 498.218 Section 498.218 Employees... § 498.218 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ. (b) The transcript of testimony, exhibits and other evidence admitted at...

  3. 20 CFR 498.218 - The record.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false The record. 498.218 Section 498.218 Employees... § 498.218 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ. (b) The transcript of testimony, exhibits and other evidence admitted at...

  4. 20 CFR 498.218 - The record.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false The record. 498.218 Section 498.218 Employees... § 498.218 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ. (b) The transcript of testimony, exhibits and other evidence admitted at...

  5. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a review...

  6. 29 CFR 1910.218 - Forging machines.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Forging machines. 1910.218 Section 1910.218 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.218 Forging machines. (a... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording the...

  7. 22 CFR 218.33 - Mediation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Mediation. 218.33 Section 218.33 Foreign... § 218.33 Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and Conciliation Service all complaints that: (1) fall within the jurisdiction of these...

  8. 22 CFR 218.33 - Mediation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Mediation. 218.33 Section 218.33 Foreign... § 218.33 Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and Conciliation Service all complaints that: (1) fall within the jurisdiction of these...

  9. 22 CFR 218.33 - Mediation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Mediation. 218.33 Section 218.33 Foreign... § 218.33 Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and Conciliation Service all complaints that: (1) fall within the jurisdiction of these...

  10. 49 CFR 218.3 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Application. 218.3 Section 218.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.3 Application. (a) Except as provided in paragraph (b...

  11. 49 CFR 218.3 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Application. 218.3 Section 218.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.3 Application. (a) Except as provided in paragraph (b...

  12. 22 CFR 218.24 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Information requirements. 218.24 Section 218.24... OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 218.24 Information requirements. Each recipient shall: (a) Make available upon request to the agency information necessary to...

  13. 42 CFR 438.218 - Enrollee information.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Enrollee information. 438.218 Section 438.218 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... and Operation Standards § 438.218 Enrollee information. The requirements that States must meet under...

  14. 14 CFR 13.218 - Motions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Motions. 13.218 Section 13.218 Aeronautics... AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.218 Motions. (a... motion. A party shall comply with the requirements of this section when filing a motion with the...

  15. 14 CFR 13.218 - Motions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Motions. 13.218 Section 13.218 Aeronautics... AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.218 Motions. (a... motion. A party shall comply with the requirements of this section when filing a motion with the...

  16. 14 CFR 13.218 - Motions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Motions. 13.218 Section 13.218 Aeronautics... AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.218 Motions. (a... motion. A party shall comply with the requirements of this section when filing a motion with the...

  17. 14 CFR 13.218 - Motions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Motions. 13.218 Section 13.218 Aeronautics... AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.218 Motions. (a... motion. A party shall comply with the requirements of this section when filing a motion with the...

  18. 10 CFR 218.10 - Rule.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Rule. 218.10 Section 218.10 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.10 Rule. (a) Upon the determination by the President that an international energy supply emergency exists, firms engaged in...

  19. 10 CFR 218.10 - Rule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Rule. 218.10 Section 218.10 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.10 Rule. (a) Upon the determination by the President that an international energy supply emergency exists, firms engaged in...

  20. 10 CFR 218.10 - Rule.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Rule. 218.10 Section 218.10 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.10 Rule. (a) Upon the determination by the President that an international energy supply emergency exists, firms engaged in...

  1. 10 CFR 218.10 - Rule.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Rule. 218.10 Section 218.10 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.10 Rule. (a) Upon the determination by the President that an international energy supply emergency exists, firms engaged in...

  2. 49 CFR 218.9 - Civil penalty.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Civil penalty. 218.9 Section 218.9 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.9 Civil penalty. Any person (an entity of any type... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of...

  3. 49 CFR 218.9 - Civil penalty.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Civil penalty. 218.9 Section 218.9 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.9 Civil penalty. Any person (an entity of any type... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  4. 49 CFR 218.9 - Civil penalty.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Civil penalty. 218.9 Section 218.9 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.9 Civil penalty. Any person (an entity of any type... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  5. 49 CFR 218.9 - Civil penalty.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Civil penalty. 218.9 Section 218.9 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.9 Civil penalty. Any person (an entity of any type... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  6. 49 CFR 218.9 - Civil penalty.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Civil penalty. 218.9 Section 218.9 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.9 Civil penalty. Any person (an entity of any type... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  7. 20 CFR 498.218 - The record.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false The record. 498.218 Section 498.218 Employees... § 498.218 The record. (a) The hearing shall be recorded and transcribed. Transcripts may be obtained following the hearing from the ALJ. (b) The transcript of testimony, exhibits and other evidence admitted at...

  8. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a...

  9. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a...

  10. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a...

  11. 31 CFR 800.218 - Lead agency.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Lead agency. 800.218 Section 800.218... FOREIGN PERSONS Definitions § 800.218 Lead agency. The term lead agency means an agency designated by the... activity for which the Chairperson designates it as a lead agency, including all or a portion of a...

  12. 10 CFR 218.11 - Supply orders.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Supply orders. 218.11 Section 218.11 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.11 Supply orders. (a) A...) The DOE shall serve a copy of the supply order on the firm directed to act as stated therein. (c)...

  13. 10 CFR 218.11 - Supply orders.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Supply orders. 218.11 Section 218.11 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.11 Supply orders. (a) A...) The DOE shall serve a copy of the supply order on the firm directed to act as stated therein. (c)...

  14. 49 CFR 218.4 - Preemptive effect.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Preemptive effect. 218.4 Section 218.4 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.4 Preemptive effect. Normal...

  15. 49 CFR 218.4 - Preemptive effect.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Preemptive effect. 218.4 Section 218.4 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.4 Preemptive effect. Normal...

  16. 49 CFR 218.4 - Preemptive effect.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Preemptive effect. 218.4 Section 218.4 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.4 Preemptive effect. Normal...

  17. 49 CFR 218.4 - Preemptive effect.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Preemptive effect. 218.4 Section 218.4 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.4 Preemptive effect. Normal...

  18. 49 CFR 218.4 - Preemptive effect.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Preemptive effect. 218.4 Section 218.4 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.4 Preemptive effect. Normal...

  19. 28 CFR 2.218 - Revocation decisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Revocation decisions. 2.218 Section 2.218..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS District of Columbia Supervised Releasees § 2.218 Revocation... revocation), a further term of supervised release imposed by the Commission under this paragraph shall...

  20. 20 CFR 218.27 - Vacation pay.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Vacation pay. 218.27 Section 218.27 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT ANNUITY BEGINNING AND... Beginning Date § 218.27 Vacation pay. (a) From railroad employer. Vacation pay may be credited to...

  1. 36 CFR 21.8 - Employee certification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Employee certification. 21.8 Section 21.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR HOT SPRINGS NATIONAL PARK; BATHHOUSE REGULATIONS § 21.8 Employee certification. (a) Employees engaged...

  2. 10 CFR 218.32 - Review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Review. 218.32 Section 218.32 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Procedures § 218.32 Review. (a) Purpose and scope. This subpart establishes the procedures for the filing of an application for review of a supply order...

  3. 30 CFR 218.56 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Definitions. 218.56 Section 218.56 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Oil and Gas, General § 218.56...

  4. 30 CFR 218.54 - Late payments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Late payments. 218.54 Section 218.54 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Oil and Gas, General § 218.54 Late...

  5. 30 CFR 218.105 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Definitions. 218.105 Section 218.105 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Oil and Gas, Onshore § 218.105...

  6. 22 CFR 218.34 - Investigation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Investigation. 218.34 Section 218.34 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Investigation, Conciliation, and Enforcement Procedures § 218.34 Investigation. (a) Informal investigation. (1) The agency will investigate complaints that...

  7. 22 CFR 218.34 - Investigation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Investigation. 218.34 Section 218.34 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Investigation, Conciliation, and Enforcement Procedures § 218.34 Investigation. (a) Informal investigation. (1) The agency will investigate complaints that...

  8. 22 CFR 218.34 - Investigation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Investigation. 218.34 Section 218.34 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Investigation, Conciliation, and Enforcement Procedures § 218.34 Investigation. (a) Informal investigation. (1) The agency will investigate complaints that...

  9. 22 CFR 218.34 - Investigation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Investigation. 218.34 Section 218.34 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Investigation, Conciliation, and Enforcement Procedures § 218.34 Investigation. (a) Informal investigation. (1) The agency will investigate complaints that...

  10. 10 CFR 218.40 - Investigations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Investigations. 218.40 Section 218.40 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Investigations, Violations, Sanctions and Judicial Actions § 218.40 Investigations. (a) The DOE may initiate and conduct investigations relating...

  11. 10 CFR 218.40 - Investigations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Investigations. 218.40 Section 218.40 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Investigations, Violations, Sanctions and Judicial Actions § 218.40 Investigations. (a) The DOE may initiate and conduct investigations relating...

  12. 10 CFR 218.40 - Investigations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Investigations. 218.40 Section 218.40 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Investigations, Violations, Sanctions and Judicial Actions § 218.40 Investigations. (a) The DOE may initiate and conduct investigations relating...

  13. 49 CFR 218.35 - Yard limits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Yard limits. 218.35 Section 218.35 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Trains and Locomotives § 218.35 Yard limits. (a) After August 1, 1977, yard limits must be designated by— (1) Yard limit signs, and (2) Timetable, train orders...

  14. 49 CFR 218.35 - Yard limits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Yard limits. 218.35 Section 218.35 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Trains and Locomotives § 218.35 Yard limits. (a) After August 1, 1977, yard limits must be designated by— (1) Yard limit signs, and (2) Timetable, train orders...

  15. 7 CFR 58.218 - Surge tanks.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Surge tanks. 58.218 Section 58.218 Agriculture....218 Surge tanks. If surge tanks are used for hot milk, and temperatures of product including foam being held in the surge tank during processing, is not maintained at a minimum of 150 °F, then two...

  16. 29 CFR 1910.218 - Forging machines.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Forging machines. 1910.218 Section 1910.218 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.218 Forging machines. (a... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording...

  17. 29 CFR 1910.218 - Forging machines.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Forging machines. 1910.218 Section 1910.218 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.218 Forging machines. (a... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording...

  18. 29 CFR 1910.218 - Forging machines.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Forging machines. 1910.218 Section 1910.218 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.218 Forging machines. (a... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording...

  19. 29 CFR 1910.218 - Forging machines.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Forging machines. 1910.218 Section 1910.218 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.218 Forging machines. (a... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording...

  20. Astatine-211-labeled radiotherapeutics: an emerging approach to targeted alpha-particle radiotherapy.

    PubMed

    Zalutsky, M R; Vaidyanathan, G

    2000-09-01

    Targeted radiotherapy or endoradiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor while sparing normal tissues. Radionuclides that decay by the emission of alpha-particles such as the heavy halogen astatine-211 (211At) offer the exciting prospect of combining cell-specific molecular targets with radiation having a range in tissue of only a few cell diameters. Herein, the radiobiological advantages of alpha-particle targeted radiotherapy will be reviewed, and the rationale for using 211At for this purpose will be described. The chemistry of astatine is similar to that of iodine; however, there are important differences which make the synthesis and evaluation of 211At-labeled compounds more challenging. Perhaps the most successful approach that has been developed involves the astatodemetallation of tin, silicon or mercury precursors. Astatine-211 labeled agents that have been investigated for targeted radiotherapy include [211At]astatide, 211At- labeled particulates, 211At-labeled naphthoquinone derivatives, 211At-labeled methylene blue, 211At-labeled DNA precursors, meta-[211At]astatobenzylguanidine, 211At-labeled biotin conjugates, 211At-labeled bisphosphonates, and 211At-labeled antibodies and antibody fragments. The status of these 211At-labeled compounds will be discussed in terms of their labeling chemistry, cytotoxicity in cell culture, as well as their tissue distribution and therapeutic efficacy in animal models of human cancers. Finally, an update on the status of the first clinical trial with an 211At-labeled targeted therapeutic, 211At-labeled chimeric anti-tenascin antibody 81C6, will be provided.

  1. Radioimmunotherapy with astatine-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma.

    PubMed

    Cheng, Junping; Ekberg, Tomas; Engström, Mats; Nestor, Marika; Jensen, Holger J; Tolmachev, Vladimir; Anniko, Matti

    2007-06-01

    In advanced head and neck squamous cell carcinoma (HNSCC), there is a need for an adjuvant treatment. We aim to evaluate the biodistribution and therapeutic effect of radioimmunotherapy using the alpha emitting, astatine-211-labeled, chimeric monoclonal antibody U36 (U36) on the HNSCC cell line UT-SCC7 in vivo. Xenograft tumors were inoculated subcutaneously in nude mice. Astatine-211-labeled U36 was injected intravenously with or without blocking of target with nonlabeled U36. In the biodistribution experiments, radioactivity was measured in tumors and various organs at set time points. In the therapeutic experiments, two groups (with or without blocking) received therapy, and the tumor growth was compared with that of controls. In addition, one group received nonlabeled U36 only. The biodistribution experiments demonstrated that astatine-211-labeled U36 could target UT-SCC7 xenografts in nude mice. With time, uptake increased in tumors and decreased in normal organs. Nonlabeled U36 did not influence tumor growth. In the two therapy groups, 18 of 20 tumors responded to therapy by decreasing or stabilizing their volumes. Significant difference was seen between the treated groups and the controls (P < .05). The study illustrates the specific binding of astatine-211-labeled U36 to HNSCC and suggests radioimmunotherapy with the alpha emitting radionuclide to be a useful treatment modality.

  2. Biodistributions, Myelosuppression and Toxicities in Mice Treated with an Anti-CD45 Antibody Labeled with the α-Emitting Radionuclides Bismuth-213 or Astatine-211

    PubMed Central

    Nakamae, Hirohisa; Wilbur, D. Scott; Hamlin, Donald K.; Thakar, Monica S.; Santos, Erlinda B.; Fisher, Darrell R.; Kenoyer, Aimee L.; Pagel, John M.; Press, Oliver W.; Storb, Rainer; Sandmaier, Brenda M.

    2009-01-01

    We previously investigated the potential of targeted radiotherapy using a bismuth-213-labeled anti-CD45 antibody to replace total body irradiation as conditioning for hematopoietic cell transplantation in a canine model. While this approach allowed sustained marrow engraftment, limited availability, high cost and short half-life of bismuth-213 induced us to investigate an alternative α-emitting radionuclide, astatine-211, for the same application. Biodistribution and toxicity studies were conducted with conjugates of the anti-murine CD45 antibody 30F11 with either bismuth-213 or astatine-211. Mice were injected with 2−50 μCi on 10 μg or 20 μCi on 2 or 40 μg 30F11 conjugate. Biodistribution studies showed that the spleen contained the highest concentration of radioactivity, ranging from 167±23 to 417±109 % injected dose/gram (%ID/g) after injection of the astatine-211 conjugate and 45±9 to 166±11 %ID/g after injection of the bismuth-213 conjugate. The higher concentrations observed for astatine-211-labeled 30F11 were due to its longer half-life, which permitted better localization of isotope to the spleen before decay. Astatine-211 was more effective at producing myelosuppression for the same quantity of injected radioactivity. All mice injected with 20 or 50 μCi astatine-211 but none with the same quantities of bismuth-213 had lethal myeloablation. Severe reversible acute hepatic toxicity occurred with 50 μCi bismuth-213, but not with lower doses of bismuth-213 or with any dose of astatine-211. No renal toxicity occurred with either radionuclide. The data suggest that smaller quantities of astatine-211-labeled anti-CD45 antibody are sufficient to achieve myelosuppression and myeloablation with less non-hematological toxicity compared with bismuth-213-labeled antibody. PMID:19244101

  3. Astatine-211 labeling of an anti-melanoma antibody and its Fab fragment using N-succinimidyl para[{sup 211} At]astatobenzoate : comparisons In Vivo with the para-[{sup 125}1]iodobenzoyl conjugate.

    SciTech Connect

    Hadley, S. W.; Wilbur, D. S.; Gray, M. A.; Atcher, R. W.; Chemistry; NeoRx Corp.; Univ. of Washington Medical Center

    1991-01-01

    Astatine-211 labeling of an anti-melanoma antibody, NR-ML-05, and its Fab fragment using N-succinimidyl para[{sup 211} At]astatobenzoate has been described. Preparation of the astatinated intermediate 2a was accomplished by distilling astatine-211 from an irradiated bismuth target directly into a reaction mixture containing an organometallic compound, N-succinimidyl p-(tri-n-butylstannyl)benzoate (1), and an oxidant, N-chlorosuccinimide, in 5% HOAc/MeOH. Trapping of distilled astatine as 2a was found to be efficient, resulting in 70-90% yields based on the amount of astatine-211 which ranged from 20% to 75%. Conjugation of 2a to NR-ML-05 and its Fab fragment was accomplished in 40-60% yields. The [{sup 211}At]astatobenzoyl-conjugated antibodies were found to be stable in vitro when challenged by strong denaturants and nucleophilic reagents. Coinjected dual-labeled studies of the 2a astatinated antibodies and the same antibodies labeled with N-succinimidyl p-[{sup 125}I]iodobenzoate (2b) in athymic mice bearing the human tumor xenograft A375 Met/Mix demonstrated that both radiolabeled antibodies had equivalent tumor localization. Data from the dual-labeled biodistribution of the intact antibody suggests that the astatine is stably attached. Data from the dual-labeled Fab fragment suggests that a portion of the astatine label is released as astatide, either from the astatinated Fab or from a catabolite.

  4. Production of [(211)At]-astatinated radiopharmaceuticals and applications in targeted α-particle therapy.

    PubMed

    Guérard, François; Gestin, Jean-François; Brechbiel, Martin W

    2013-02-01

    (211)At is a promising radionuclide for α-particle therapy of cancers. Its physical characteristics make this radionuclide particularly interesting to consider when bound to cancer-targeting biomolecules for the treatment of microscopic tumors. (211)At is produced by cyclotron irradiation of (209)Bi with α-particles accelerated at ~28 MeV and can be obtained in high radionuclidic purity after isolation from the target. Its chemistry resembles iodine, but there is also a tendency to behave as a metalloid. However, the chemical behavior of astatine has not yet been clearly established, primarily due to the lack of any stable isotopes of this element, which precludes the use of conventional analytical techniques for its characterization. There are also only a limited number of research centers that have been able to produce this element in sufficient amounts to carry out extensive investigations. Despite these difficulties, chemical reactions typically used with iodine can be performed, and a number of biomolecules of interest have been labeled with (211)At. However, most of these compounds exhibit unacceptable instability in vivo due to the weakness of the astatine-biomolecule bond. Nonetheless, several compounds have shown high potential for the treatment of cancers in vitro and in several animal models, thus providing a promising basis that has allowed initiation of the first two clinical studies.

  5. 36 CFR 2.18 - Snowmobiles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Snowmobiles. 2.18 Section 2... PROTECTION, PUBLIC USE AND RECREATION § 2.18 Snowmobiles. (a) Notwithstanding the definition of vehicle set... register more than 86 decibels on the A-weighted scale at 50 feet. All decibel measurements shall be based...

  6. 36 CFR 2.18 - Snowmobiles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Snowmobiles. 2.18 Section 2... PROTECTION, PUBLIC USE AND RECREATION § 2.18 Snowmobiles. (a) Notwithstanding the definition of vehicle set... register more than 86 decibels on the A-weighted scale at 50 feet. All decibel measurements shall be based...

  7. 9 CFR 201.218 - Arbitration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Arbitration. 201.218 Section 201.218 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... the contract in bold conspicuous print: “Right to Decline Arbitration. A poultry grower, livestock...

  8. 42 CFR 93.218 - Person.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Person. 93.218 Section 93.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH...

  9. 7 CFR 1430.218 - Assignments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Assignments. 1430.218 Section 1430.218 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Assignments. Any producer may assign a payment to be made under this part in accordance with part 1404 of this...

  10. 10 CFR 218.43 - Injunctions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Injunctions. 218.43 Section 218.43 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Investigations, Violations, Sanctions and... appropriate district court of the United States to enjoin such acts or practices and, upon a proper showing,...

  11. 22 CFR 218.11 - Standards.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Standards. 218.11 Section 218.11 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Standards for Determining Age Discrimination §...

  12. 50 CFR 218.121 - Effective dates.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Effective dates. 218.121 Section 218.121 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Effective dates. Amended regulations in this subpart are effective February 1, 2012, through May 4, 2016. ...

  13. 50 CFR 218.121 - Effective dates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Effective dates. 218.121 Section 218.121 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Effective dates. Regulations in this subpart are effective from May 4, 2011, through May 4, 2016. ...

  14. 50 CFR 218.121 - Effective dates.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Effective dates. 218.121 Section 218.121 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Effective dates. Amended regulations in this subpart are effective February 1, 2012, through May 4, 2016. ...

  15. 50 CFR 218.121 - Effective dates.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Effective dates. 218.121 Section 218.121 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Effective dates. Amended regulations in this subpart are effective February 1, 2012, through May 4, 2016. ...

  16. 14 CFR 218.7 - Presumption.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Presumption. 218.7 Section 218.7 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC... that true operational control and safety responsibility are exercised by the lessor, and that the...

  17. 14 CFR 218.2 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Applicability. 218.2 Section 218.2 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC... operational control and safety responsibility is deemed to be the carrier, and is required to have appropriate...

  18. 27 CFR 24.218 - Other wine.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Other wine. 24.218 Section... THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.218 Other wine. (a) General. Other than standard wine not included in other sections in this subpart are considered other wine. Those...

  19. 27 CFR 24.218 - Other wine.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Other wine. 24.218 Section... THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.218 Other wine. (a) General. Other than standard wine not included in other sections in this subpart are considered other wine. Those...

  20. 27 CFR 24.218 - Other wine.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Other wine. 24.218 Section... THE TREASURY ALCOHOL WINE Production of Other Than Standard Wine § 24.218 Other wine. (a) General. Other than standard wine not included in other sections in this subpart are considered other wine. Those...

  1. 27 CFR 24.218 - Other wine.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Other wine. 24.218 Section... THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.218 Other wine. (a) General. Other than standard wine not included in other sections in this subpart are considered other wine. Those...

  2. 27 CFR 24.218 - Other wine.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Other wine. 24.218 Section... THE TREASURY ALCOHOL WINE Production of Other Than Standard Wine § 24.218 Other wine. (a) General. Other than standard wine not included in other sections in this subpart are considered other wine. Those...

  3. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Judges. 134.218 Section 134.218 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Administrative Law Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge...

  4. 48 CFR 52.218 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false 52.218 Section 52.218 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses...

  5. 42 CFR 93.218 - Person.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Person. 93.218 Section 93.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT...

  6. 30 CFR 218.10 - Information collection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Information collection. 218.10 Section 218.10 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES General Provisions §...

  7. 36 CFR 218.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PREDECISIONAL ADMINISTRATIVE REVIEW PROCESS General Provisions § 218.2 Definitions. The following definitions... of the receiving office on the last day of the filing period (§ 218.6(a)). Objection process. The... transcriptions or other notes from oral statements or presentation. For the purposes of this rule,...

  8. 36 CFR 218.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PREDECISIONAL ADMINISTRATIVE REVIEW PROCESS General Provisions § 218.2 Definitions. The following definitions... of the receiving office on the last day of the filing period (§ 218.6(a)). Objection process. The... transcriptions or other notes from oral statements or presentation. For the purposes of this rule,...

  9. 42 CFR 93.218 - Person.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Person. 93.218 Section 93.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT...

  10. 42 CFR 93.218 - Person.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Person. 93.218 Section 93.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT...

  11. 42 CFR 93.218 - Person.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Person. 93.218 Section 93.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT...

  12. 30 CFR 218.153 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false 218.153 Section 218.153 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE COLLECTION OF ROYALTIES, RENTALS, BONUSES, AND OTHER MONIES DUE THE FEDERAL GOVERNMENT Oil, Gas and Sulfur, Offshore §...

  13. 42 CFR 57.218 - Noncompliance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Noncompliance. 57.218 Section 57.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS Health Professions Student Loans §...

  14. 42 CFR 57.218 - Noncompliance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Noncompliance. 57.218 Section 57.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS Health Professions Student Loans §...

  15. 42 CFR 57.218 - Noncompliance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Noncompliance. 57.218 Section 57.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS Health Professions Student Loans §...

  16. 42 CFR 57.218 - Noncompliance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Noncompliance. 57.218 Section 57.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS Health Professions Student Loans §...

  17. 31 CFR 31.218 - Enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Enforcement. 31.218 Section 31.218 Money and Finance: Treasury Office of the Secretary of the Treasury TROUBLED ASSET RELIEF PROGRAM... is of the utmost importance. In the event a retained entity or any individual or entity providing...

  18. 9 CFR 381.218 - Criminal offenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Criminal offenses. 381.218 Section 381... CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Detention; Seizure and Condemnation; Criminal Offenses § 381.218 Criminal offenses. The Act contains criminal provisions with respect to numerous offenses...

  19. 9 CFR 381.218 - Criminal offenses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Criminal offenses. 381.218 Section 381... CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Detention; Seizure and Condemnation; Criminal Offenses § 381.218 Criminal offenses. The Act contains criminal provisions with respect to numerous offenses...

  20. Environmental properties of polonium-218

    SciTech Connect

    Goldstein, S.D.

    1983-01-01

    An investigation was undertaken of the atmospheric chemistry of the radon decay product polonium-218. Previous work has indicated that two mechanisms of neutralization of the singly charged ion exist. Charged RaA can be neutralized by reacting with oxygen to form a polonium oxide ion that has a higher ionization potential than that of the polonium metal, and then accepting an electron transferred from a lower ionization potential gas. It was been determined that the polonium dioxide has an ionization potential in the range of 10.35 to 10.53 eV. It has also been determined that RaA can be neutralized, in the absence of oxygen, from the scavenging of electrons by a trace gas such as water or nitrogen dioxide and the diffusion to the polonium ion. To verify the presence of the second neutralization mechanism, nitrogen dioxide in nitrogen concentrations in the range of 1 ppM to 50 ppB were examined. Complete neutralization of RaA was observed at nitrogen dioxide concentrations greater than 700 ppB. For concentrations less than 700 ppB, the degree of neutralization was found to decrease. 12 references, 3 figures, 8 tables.

  1. 49 CFR 218.23 - Blue signal display.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Blue signal display. 218.23 Section 218.23... signal display. (a) Blue signals displayed in accordance with § 218.25, 218.27, or 218.29 signify that workers are on, under, or between rolling equipment. When so displayed— (1) The equipment may not...

  2. 49 CFR 218.23 - Blue signal display.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Blue signal display. 218.23 Section 218.23... signal display. (a) Blue signals displayed in accordance with § 218.25, 218.27, or 218.29 signify that workers are on, under, or between rolling equipment. When so displayed— (1) The equipment may not...

  3. 49 CFR 218.23 - Blue signal display.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Blue signal display. 218.23 Section 218.23... signal display. (a) Blue signals displayed in accordance with § 218.25, 218.27, or 218.29 signify that workers are on, under, or between rolling equipment. When so displayed— (1) The equipment may not...

  4. 49 CFR 218.23 - Blue signal display.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Blue signal display. 218.23 Section 218.23... signal display. (a) Blue signals displayed in accordance with § 218.25, 218.27, or 218.29 signify that workers are on, under, or between rolling equipment. When so displayed— (1) The equipment may not...

  5. 49 CFR 218.23 - Blue signal display.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Blue signal display. 218.23 Section 218.23... signal display. (a) Blue signals displayed in accordance with § 218.25, 218.27, or 218.29 signify that workers are on, under, or between rolling equipment. When so displayed— (1) The equipment may not...

  6. Investigation of astatine(III) hydrolyzed species: experiments and relativistic calculations.

    PubMed

    Champion, Julie; Sabatié-Gogova, Andréa; Bassal, Fadel; Ayed, Tahra; Alliot, Cyrille; Galland, Nicolas; Montavon, Gilles

    2013-03-07

    This work aims to resolve some controversies about astatine(III) hydroxide species present in oxidant aqueous solution. AtO(+) is the dominant species existing under oxidizing and acidic pH conditions. This is consistent with high-performance ion-exchange chromatography data showing the existence of one species holding one positive charge. A change in speciation occurs as the pH changes from 1 to 4, while remaining under oxidizing conditions. Dynamic experiments with ion-exchange resins evidence the existence of a neutral species witnessed by its elution in the void volume. Batch-experiments using a competition method show the exchange of one proton indicating the formation of the AtO(OH) species. The hydrolysis thermodynamic constant, extrapolated to zero ionic strength, was determined to be 10(-1.9). This value is supported by two-component relativistic quantum calculations and therefore allows disclosing unambiguously the structure of the formed species.

  7. Complexation study on no-carrier-added astatine with insulin: a candidate radiopharmaceutical.

    PubMed

    Lahiri, Susanta; Roy, Kamalika; Sen, Souvik

    2008-12-01

    No-carrier-added astatine radionuclides produced in the (7)Li-irradiated lead matrix were separated from bulk lead nitrate target by complexing At with insulin, followed by dialysis. The method offers simultaneous separation of At from lead as well as its complexation with insulin. The At-insulin complex might be a potential radiopharmaceutical in the treatment of hepatocellular carcinoma. The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. It has been found that the half-life of At-insulin complex is about approximately 12h, when dialyzed against deionized water and is only 6h, when dialyzed against RL solution having the same composition as blood serum. The 6h half-life of this Insulin-At complex is perfect for killing cancer cells from external cell surfaces as the half-life of internalization of insulin molecule inside the cell is 7-12h.

  8. Poster - Thur Eve - 15: Production and assessment of astatine-211 for targeted alpha therapy.

    PubMed

    Crawford, J; Beckham, W; Jirasek, A; Ruth, T

    2012-07-01

    Biologically-targeted alpha-particle radiation is the basis of new and promising treatments for eliminating disseminated micrometastases and the residual microscopic malignancies that remain after surgery or radiation therapy. The short-range alpha-particles are highly cytotoxic and capable of inactivating single, isolated cancer cells which may otherwise cause recurrence. Astatine-211 is a promising alpha emitter for therapy; the 7.2 hour half-life of (211) At provides sufficient time for biological-targeting to take place. However, this radionuclide is in short supply and future treatment strategies still require extensive preclinical evaluation. The present work aims to develop technologies that (1) increase the world-wide availability of (211) At for clinical use, and (2) assess the risks of (211) At-based therapies by quantifying the activity distributions in animal models. At TRIUMF (Vancouver, BC), the feasibility of a novel generator system for (211) At is under investigation which would allow distribution of (211) At across Canada and internationally. Briefly, a longer-lived parent radionuclide of (211) At, radon-211, would be produced and allowed to decay in containment to yield (211) At in solution. Additionally, a supplementary study is underway in collaboration with the University of Washington to evaluate the sub-organ biodistributions of astatinated targeting biomolecules, with cell-level resolution. These measurements involve high resolution quantitative alpha-particle imaging in thin tissue samples and can be done for a selection of applications (eg. lymphoma, metastatic prostate cancer, etc) using animal models. The planned alpha-camera measurements are primarily designed to predict and assess the risk of toxicity associated with (211) At-based therapies and aid in developing the future clinical applications. © 2012 American Association of Physicists in Medicine.

  9. Nuclear data sheets update for A = 218

    SciTech Connect

    Akovali, Y. A.

    1995-11-01

    The available nuclear structure information for all nuclei with mass number A = 218 is presented. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given.

  10. 36 CFR 218.13 - Secretary's authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Authorized by the Healthy Forests Restoration Act of 2003 § 218.13 Secretary's authority. (a) Nothing in this... Environment, are not subject to the procedures set forth in this subpart. A decision by the Secretary or...

  11. 50 CFR 218.231 - Effective dates.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and Importing of Marine Mammals; Navy Operations of Surveillance Towed Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.231 Effective dates. Regulations are effective August 15,...

  12. 50 CFR 218.231 - Effective dates.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... and Importing of Marine Mammals; Navy Operations of Surveillance Towed Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.231 Effective dates. Regulations are effective August 15,...

  13. 50 CFR 218.231 - Effective dates.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... and Importing of Marine Mammals; Navy Operations of Surveillance Towed Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.231 Effective dates. Regulations are effective August 15,...

  14. 36 CFR 218.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Authorized by the Healthy Forests Restoration Act of 2003 § 218.2 Definitions. Address: An individual's or... reduction project: A hazardous fuel reduction project authorized by the Healthy Forests Restoration Act of...

  15. 36 CFR 218.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Authorized by the Healthy Forests Restoration Act of 2003 § 218.2 Definitions. Address: An individual's or... reduction project: A hazardous fuel reduction project authorized by the Healthy Forests Restoration Act of...

  16. 50 CFR 218.241 - Adaptive management.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Low Frequency Active (SURTASS LFA) Sonar § 218.241 Adaptive management. NMFS may modify (including...) Results from the Navy's monitoring from the previous year's operation of SURTASS LFA sonar. (b)...

  17. 50 CFR 218.241 - Adaptive management.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Low Frequency Active (SURTASS LFA) Sonar § 218.241 Adaptive management. NMFS may modify (including...) Results from the Navy's monitoring from the previous year's operation of SURTASS LFA sonar. (b)...

  18. 36 CFR 2.18 - Snowmobiles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROTECTION, PUBLIC USE AND RECREATION § 2.18 Snowmobiles. (a) Notwithstanding the definition of vehicle set... and vehicles are not clearly visible for a distance of 500 feet. (3) Operating a snowmobile that does...

  19. Specific inactivation of sensitized lymphocytes in vitro using antigens labelled with astatine-211

    PubMed Central

    Smit, J. A.; Myburgh, J. A.; Neirinckx, R. D.

    1973-01-01

    This is a study of the use of astatine-211 as an alternative to iodine isotopes in radioactive antigen suicide experiments. The theoretical advantages of 211At are that it is a high energy (5·87 MeV), short half-life (7·2 hr)α-emitter with a short path length of 60 μm. Its destructive effect, measured in terms of degree of ionization per micron is 300 times that of 125I and 131I. Streptokinase (SK), tuberculin (PPD) and phytohaemagglutinin (PHA) were labelled electrolytically with 211At (3–9% incorporation). These antigens were not destroyed by the labelling technique or by self-irradiation during radioactive decay. Autoradiography showed that only a small fraction of lymphocytes bound 211At-labelled SK and PPD whilst most lymphocytes bound 211At-labelled PHA. Lymphocytes exposed for 40 min to 0·35–1·40 μCi of labelled antigens lost 35–83% of their ability to transform upon subsequent exposure to the unlabelled antigens. The inhibition was specific in that responsiveness to unrelated antigens was retained. These results extend our previous findings with the use of 211At in in vivo antigen suicide experiments. ImagesFig. 1(a)Fig. 1(b) PMID:4716099

  20. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    PubMed

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Production of [211At]-Astatinated Radiopharmaceuticals and Applications in Targeted α-Particle Therapy

    PubMed Central

    Guérard, François; Gestin, Jean-François

    2013-01-01

    Abstract 211At is a promising radionuclide for α-particle therapy of cancers. Its physical characteristics make this radionuclide particularly interesting to consider when bound to cancer-targeting biomolecules for the treatment of microscopic tumors. 211At is produced by cyclotron irradiation of 209Bi with α-particles accelerated at ∼28 MeV and can be obtained in high radionuclidic purity after isolation from the target. Its chemistry resembles iodine, but there is also a tendency to behave as a metalloid. However, the chemical behavior of astatine has not yet been clearly established, primarily due to the lack of any stable isotopes of this element, which precludes the use of conventional analytical techniques for its characterization. There are also only a limited number of research centers that have been able to produce this element in sufficient amounts to carry out extensive investigations. Despite these difficulties, chemical reactions typically used with iodine can be performed, and a number of biomolecules of interest have been labeled with 211At. However, most of these compounds exhibit unacceptable instability in vivo due to the weakness of the astatine–biomolecule bond. Nonetheless, several compounds have shown high potential for the treatment of cancers in vitro and in several animal models, thus providing a promising basis that has allowed initiation of the first two clinical studies. PMID:23075373

  2. Ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and ionic radii of element Uus (Z = 117) and astatine.

    PubMed

    Chang, Zhiwei; Li, Jiguang; Dong, Chenzhong

    2010-12-30

    Multiconfiguration Dirac-Fock (MCDF) method was employed to calculate the first five ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and radii for the element Uus and its homologue At. Main valence correlation effects were taken into account. The Breit interaction and QED effects were also estimated. The uncertainties of calculated IPs, EAs, and IR for Uus and At were reduced through an extrapolation procedure. The good consistency with available experimental and other theoretical values demonstrates the validity of the present results. These theoretical data therefore can be used to predict some unknown physicochemical properties of element Uus, Astatine, and their compounds.

  3. Separation of no-carrier-added astatine radionuclides from α-particle irradiated lead bismuth eutectic target: A classical method.

    PubMed

    Maiti, Moumita; Lahiri, Susanta; Kumar, Deepak; Choudhury, Dibyasree

    2017-09-01

    Possibility of separation of no-carrier-added (NCA) astatine radionuclides from the bulk lead-bismuth-eutectic (LBE) target was explored in a simple way in the laboratory scale. A LBE target was irradiated by 40MeV α-particles delivered from a cyclotron facility, India. Quantitative analysis of the irradiated target indicated the production of (210,209)At, (207)Po radionuclides in the target matrix. The (210,209)At radionuclides were separated by precipitation of bulk Pb, Bi and NCA radiotoxic Po radionuclides. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. 40 CFR 35.218 - Award limitation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ASSISTANCE Environmental Program Grants Hazardous Waste Management (section 3011(a)) § 35.218 Award limitation. The Regional Administrator will not award Hazardous Waste Management Grants to a State with interim or final hazardous waste authorization unless the applicant is the lead agency designated in the...

  5. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.218 Judges. (a) Assignment. The AA/OHA will assign... Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b) Authority. Except...

  6. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.218 Judges. (a) Assignment. The AA/OHA will assign... Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b) Authority. Except...

  7. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.218 Judges. (a) Assignment. The AA/OHA will assign... Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b) Authority. Except...

  8. 13 CFR 134.218 - Judges.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.218 Judges. (a) Assignment. The AA/OHA will assign... Judge. The AA/OHA will assign all other cases before OHA to either an Administrative Law Judge or an Administrative Judge, or, if the AA/OHA is a duly licensed attorney, to himself or herself. (b) Authority. Except...

  9. 10 CFR 218.10 - Rule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.10 Rule. (a) Upon the determination by the President that an international energy supply emergency exists, firms engaged in producing... that relate to the mandatory international allocation of oil by IEP participating countries. (b) Any...

  10. 36 CFR 218.14 - Judicial proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... process set forth in this subpart fully implements Congress' design for a predecisional administrative... Section 218.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PREDECISIONAL ADMINISTRATIVE REVIEW PROCESSES Predecisional Administrative Review Process for Hazardous Fuel Reduction Projects...

  11. 49 CFR 218.22 - Utility employee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Blue Signal Protection of Workers § 218.22 Utility... one or more locomotives coupled, with or without cars) and before commencing any duties with the crew... uncouple air hoses and other electrical or mechanical connections; prepare rail cars for coupling; set...

  12. 49 CFR 218.39 - Hump operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Trains and Locomotives § 218.39 Hump operations. After June 30, 1984, each railroad that operates a remote control hump yard facility must have...

  13. 9 CFR 201.218 - Arbitration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-Packers and Live Poultry Dealers § 201.218 Arbitration. (a) In any livestock or poultry production... provisions set forth in this agreement. A poultry grower, livestock producer or swine production contract... contract provides a meaningful opportunity for the poultry grower, livestock producer, or swine production...

  14. 50 CFR 218.173 - Mitigation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... in § 218.170(c), the mitigation measures contained in this subpart and subsequent Letters of... activity. (c) Visual surveillance shall be conducted just prior to all in-water exercises. (1) Surveillance... active sonar transmissions when passive acoustic monitoring capabilities are being operated during...

  15. 50 CFR 218.173 - Mitigation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... in § 218.170(c), the mitigation measures contained in this subpart and subsequent Letters of... activity. (c) Visual surveillance shall be conducted just prior to all in-water exercises. (1) Surveillance... active sonar transmissions when passive acoustic monitoring capabilities are being operated during...

  16. 10 CFR 218.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.3 Definitions. DOE... Act (Pub. L. 94-163), as amended. Firm means any association, company, corporation, estate, individual... International Energy Agency established to implement the IEP. IEP means the International Energy...

  17. 10 CFR 218.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.3 Definitions. DOE... Act (Pub. L. 94-163), as amended. Firm means any association, company, corporation, estate, individual... International Energy Agency established to implement the IEP. IEP means the International Energy...

  18. 10 CFR 218.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.3 Definitions. DOE... Act (Pub. L. 94-163), as amended. Firm means any association, company, corporation, estate, individual... International Energy Agency established to implement the IEP. IEP means the International Energy...

  19. 10 CFR 218.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.3 Definitions. DOE... Act (Pub. L. 94-163), as amended. Firm means any association, company, corporation, estate, individual... International Energy Agency established to implement the IEP. IEP means the International Energy...

  20. 10 CFR 218.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.3 Definitions. DOE... Act (Pub. L. 94-163), as amended. Firm means any association, company, corporation, estate, individual... International Energy Agency established to implement the IEP. IEP means the International Energy...

  1. 50 CFR 218.124 - Mitigation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and Importing Marine Mammals; Gulf of Alaska Temporary Maritime Activities Area (GoA TMAA) § 218.124... the “Stranding Response Plan for Major Navy Training Exercises in the GoA TMAA” (available at: http... exercises in the GoA TMAA), the Navy shall implement the procedures described below. (A) The Navy shall...

  2. 50 CFR 218.124 - Mitigation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... and Importing Marine Mammals; Gulf of Alaska Temporary Maritime Activities Area (GoA TMAA) § 218.124... the “Stranding Response Plan for Major Navy Training Exercises in the GoA TMAA” (available at: http... exercises in the GoA TMAA), the Navy shall implement the procedures described below. (A) The Navy shall...

  3. 50 CFR 218.124 - Mitigation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and Importing Marine Mammals; Gulf of Alaska Temporary Maritime Activities Area (GoA TMAA) § 218.124... the “Stranding Response Plan for Major Navy Training Exercises in the GoA TMAA” (available at: http... exercises in the GoA TMAA), the Navy shall implement the procedures described below. (A) The Navy shall...

  4. 50 CFR 218.124 - Mitigation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... and Importing Marine Mammals; Gulf of Alaska Temporary Maritime Activities Area (GoA TMAA) § 218.124... the “Stranding Response Plan for Major Navy Training Exercises in the GoA TMAA” (available at: http... exercises in the GoA TMAA), the Navy shall implement the procedures described below. (A) The Navy shall...

  5. 10 CFR 218.40 - Investigations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the DOE at any time that circumstances so warrant. ... Judicial Actions § 218.40 Investigations. (a) The DOE may initiate and conduct investigations relating to... the DOE or any order promulgated by the DOE under the authority of section 251 of EPCA, or any...

  6. 7 CFR 1280.218 - Exporter.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Assessments § 1280.218 Exporter. Each person exporting live lambs shall remit to the Board an assessment on such lambs at the time of export at the...

  7. 7 CFR 58.218 - Surge tanks.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) GRADING AND INSPECTION, GENERAL SPECIFICATIONS FOR APPROVED PLANTS AND STANDARDS FOR GRADES OF DAIRY PRODUCTS 1 General....218 Surge tanks. If surge tanks are used for hot milk, and temperatures of product including...

  8. 7 CFR 58.218 - Surge tanks.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) GRADING AND INSPECTION, GENERAL SPECIFICATIONS FOR APPROVED PLANTS AND STANDARDS FOR GRADES OF DAIRY PRODUCTS 1 General....218 Surge tanks. If surge tanks are used for hot milk, and temperatures of product including...

  9. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    SciTech Connect

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  10. Reagents for Astatination of Biomolecules. 3. Comparison of closo-Decaborate(2-) and closo-Dodecaborate(2-) Moieties as Reactive Groups for Labeling with Astatine-211

    PubMed Central

    Wilbur, D. Scott; Chyan, Ming-Kuan; Hamlin, Donald K.; Perry, Matthew A.

    2009-01-01

    In vivo deastatination has been a major problem in the development of reagents for therapeutic applications of the α-particle emitting radionuclide 211At. Our prior studies demonstrated that the use of a closo-decaborate(2-) ([closo-B10H9R]2−) moiety for 211At labeling of biomolecules provides conjugates that are stable to in vivo deastatination. In this investigation, the closo-decaborate(2-) moiety was compared with the structurally similar closo-dodecaborate(2-) ([closo-B12H11R]2−) to determine if one has more favorable properties than the other for use in pendant groups as 211At labeling molecules. To determine the differences, two sets of structurally identical molecules, with the exception that they contained either a closo-decaborate(2-) or a closo-dodecaborate(2-) moiety, were compared with regards to their synthesis, radiohalogenation, stability to in vivo deastatination and tissue distribution. Quite different rates of reaction were noted in the synthetic steps for the two closo-borate(2-) moieties, but ultimately the yields were similar, making these differences of little importance. Differences in radiohalogenation rates were also noted between the two closo-borate(2-) moieties, with the more electrophilic closo-decaborate(2-) reacting more rapidly. This resulted in somewhat higher yields of astatinated closo-decaborate(2-) derivatives (84% vs 53%), but both cage moieties gave good radioiodination yields (e.g. 79–96%). Importantly, both closo-borate(2-) cage moieties were shown to have high stability to in vivo deastatination. The largest differences between pairs of compounds containing the structurally similar boron cage moieties were in their in vivo tissue distributions. For example, [Et3NH]2B12H10I-CONHpropyl, [125I]2b had high concentrations in kidney (1h, 19.8 %ID/g; 4h, 26.5%ID/g), whereas [Et3NH]2B10H8I-CONHpropyl, [125I]1e had much lower concentrations in kidney (1h, 6.6%ID/g; 4h, 0.27%ID/g). Interestingly, when another salt of the

  11. Reagents for astatination of biomolecules. 3. Comparison of closo-decaborate(2-) and closo-dodecaborate(2-) moieties as reactive groups for labeling with astatine-211.

    PubMed

    Wilbur, D Scott; Chyan, Ming-Kuan; Hamlin, Donald K; Perry, Matthew A

    2009-03-18

    In vivo deastatination has been a major problem in the development of reagents for therapeutic applications of the alpha-particle emitting radionuclide (211)At. Our prior studies demonstrated that the use of a closo-decaborate(2-) ([closo-B(10)H(9)R](2-)) moiety for (211)At labeling of biomolecules provides conjugates that are stable to in vivo deastatination. In this investigation, the closo-decaborate(2-) moiety was compared with the structurally similar closo-dodecaborate(2-) ([closo-B(12)H(11)R](2-)) to determine if one has more favorable properties than the other for use in pendant groups as (211)At labeling molecules. To determine the differences, two sets of structurally identical molecules, with the exception that they contained either a closo-decaborate(2-) or a closo-dodecaborate(2-) moiety, were compared with regard to their synthesis, radiohalogenation, stability to in vivo deastatination and tissue distribution. Quite different rates of reaction were noted in the synthetic steps for the two closo-borate(2-) moieties, but ultimately the yields were similar, making these differences of little importance. Differences in radiohalogenation rates were also noted between the two closo-borate(2-) moieties, with the more electrophilic closo-decaborate(2-) reacting more rapidly. This resulted in somewhat higher yields of astatinated closo-decaborate(2-) derivatives (84% vs 53%), but both cage moieties gave good radioiodination yields (e.g., 79-96%). Importantly, both closo-borate(2-) cage moieties were shown to have high stability to in vivo deastatination. The largest differences between pairs of compounds containing the structurally similar boron cage moieties were in their in vivo tissue distributions. For example, [Et(3)NH](2)B(12)H(10)I-CONHpropyl, [(125)I]2b had high concentrations in kidney (1 h, 19.8%ID/g; 4 h, 26.5%ID/g), whereas [Et(3)NH](2)B(10)H(8)I-CONHpropyl, [(125)I]1e had much lower concentrations in kidney (1 h, 6.6%ID/g; 4 h, 0.27%ID

  12. Therapeutic efficacy of astatine-211-labeled trastuzumab on radioresistant SKOV-3 tumors in nude mice.

    PubMed

    Palm, Stig; Bäck, Tom; Claesson, Ingela; Danielsson, Anna; Elgqvist, Jörgen; Frost, Sofia; Hultborn, Ragnar; Jensen, Holger; Lindegren, Sture; Jacobsson, Lars

    2007-10-01

    To investigate the potential use of astatine-211 (211At)-labeled trastuzumab for the treatment of HER-2-positive, radioresistant ovarian carcinoma. Four-week-old nude mice were inoculated intraperitoneally with 5 . 10(6) SKOV-3 cells in 0.4 mL saline on Day 0. The endpoint was the total tumor weight in each mouse on Day 63. Three experiments were performed in which the response to single-dose and fractionated treatment with unlabeled and 211At-labeled antibody was evaluated. Experiment 1 showed, for the same total amount of trastuzumab, a dose-response relationship between 211At activity (0-400 kBq on Day 7) and therapeutic efficacy (p = 0.001). The effect of varying the amount of unlabeled trastuzumab was studied in Experiment 2. All mice, except for the controls, received 400 kBq 211At-trastuzumab, and different groups received 5, 50, or 500 microg trastuzumab on Day 7. The increase from 5 to 50 microg trastuzumab reduced the tumors by 78% in weight. No tumors were present in mice given 500 microg trastuzumab. In Experiment 3, the effect of a fractionated treatment regimen was studied. Mice that received 100 kBq 211At-trastuzumab on Days 7 and 8 had a 42% smaller tumor burden than did controls. Groups of mice injected with 200 + 100 kBq on Days 7 and 21 and mice injected with 100 kBq on Days 7, 8, and 21 both had 24% less tumor weight than the corresponding controls. The combination of 500 microg trastuzumab and 400 kBq 211At-trastuzumab had the greatest effect, with complete eradication of the tumors in this nude mouse model.

  13. Therapeutic Efficacy of Astatine-211-Labeled Trastuzumab on Radioresistant SKOV-3 Tumors in Nude Mice

    SciTech Connect

    Palm, Stig Baeck, Tom; Claesson, Ingela; Danielsson, Anna; Elgqvist, Joergen; Frost, Sofia; Hultborn, Ragnar; Jensen, Holger; Lindegren, Sture; Jacobsson, Lars

    2007-10-01

    Purpose: To investigate the potential use of astatine-211 ({sup 211}At)-labeled trastuzumab for the treatment of HER-2-positive, radioresistant ovarian carcinoma. Methods and Materials: Four-week-old nude mice were inoculated intraperitoneally with 5 . 10{sup 6} SKOV-3 cells in 0.4 mL saline on Day 0. The endpoint was the total tumor weight in each mouse on Day 63. Three experiments were performed in which the response to single-dose and fractionated treatment with unlabeled and {sup 211}At-labeled antibody was evaluated. Results: Experiment 1 showed, for the same total amount of trastuzumab, a dose-response relationship between {sup 211}At activity (0-400 kBq on Day 7) and therapeutic efficacy (p = 0.001). The effect of varying the amount of unlabeled trastuzumab was studied in Experiment 2. All mice, except for the controls, received 400 kBq {sup 211}At-trastuzumab, and different groups received 5, 50, or 500 {mu}g trastuzumab on Day 7. The increase from 5 to 50 {mu}g trastuzumab reduced the tumors by 78% in weight. No tumors were present in mice given 500 {mu}g trastuzumab. In Experiment 3, the effect of a fractionated treatment regimen was studied. Mice that received 100 kBq {sup 211}At-trastuzumab on Days 7 and 8 had a 42% smaller tumor burden than did controls. Groups of mice injected with 200 + 100 kBq on Days 7 and 21 and mice injected with 100 kBq on Days 7, 8, and 21 both had 24% less tumor weight than the corresponding controls. Conclusion: The combination of 500 {mu}g trastuzumab and 400 kBq {sup 211}At-trastuzumab had the greatest effect, with complete eradication of the tumors in this nude mouse model.

  14. Half-life of /sup 218/Po

    SciTech Connect

    Potapov, V.G.; Soloshenkov, P.S.

    1986-10-01

    The decay of Po 218 is accompanied by the emission of 6.00-MeV alpha particles. The most suitable method for studying it is the alphaspectrometric method. To generate radon, the source for RaA, the authors used a preparation of Ra 226 with a high degree of purity. Targets were prepared for measuring the half-life on a radon setup. Approximately 30 sec after holding in a radon atmosphere the target was placed with the polonium deposited on it into a vacuum chamber. It was noted that the intensity of the peak at 6.70 MeV decreases at the same rate as the decay of Po 218, and the ratio of the intensities of their peaks was equal to 0.037 +/- 0.007%. The spectra (alpha was analyzed on an LP-4900 analyzer. The values of the half-life that were obtained are in good agreement with the values obtained previously.

  15. The atmospheric chemistry of Po-218

    SciTech Connect

    Hopke, P.K.

    1990-09-30

    The chemical and physical properties of {sup 218}Po immediately following its formation from {sup 222}Rn decay are important in determining its behavior in indoor atmospheres and plays a major part in determining its potential health effects. In 88% of the decays, a singly charged positive ion of {sup 218}Po is obtained at the end of its recoil path. The neutralization rates for Po-218 by the small ion recombination, electron transfer or electron scavenging mechanisms were previously reported. We have measured the small ion recombination rate in high purity gases to determine the negative small ion production rate as a function of the ionization potential of the gas. Our previous studies have also shown that radiolysis of water vapor by the recoiling Po ion produces high local concentrations of hydroxyl ({center dot}OH) radicals. These radicals can lead to oxidation of reactive trace gases and the neutral polonium molecule can become incorporated in ultrafine particles formed by the nucleation of low vapor pressure compounds produced by this radical oxidation process. The hydroxyl radical production rate and the production of particles are currently being studied. 12 refs., 1 fig.

  16. 18 CFR 2.18 - Phased electric rate increase filings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Phased electric rate increase filings. 2.18 Section 2.18 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Policy and Interpretations Under the Federal Power Act § 2.18 Phased electric rate increase filings. (a...

  17. 18 CFR 2.18 - Phased electric rate increase filings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Phased electric rate increase filings. 2.18 Section 2.18 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Policy and Interpretations Under the Federal Power Act § 2.18 Phased electric rate increase filings. (a...

  18. 18 CFR 2.18 - Phased electric rate increase filings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Phased electric rate increase filings. 2.18 Section 2.18 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Policy and Interpretations Under the Federal Power Act § 2.18 Phased electric rate increase filings. (a...

  19. 18 CFR 2.18 - Phased electric rate increase filings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Phased electric rate increase filings. 2.18 Section 2.18 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Policy and Interpretations Under the Federal Power Act § 2.18 Phased electric rate increase filings. (a...

  20. 18 CFR 2.18 - Phased electric rate increase filings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Phased electric rate increase filings. 2.18 Section 2.18 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Policy and Interpretations Under the Federal Power Act § 2.18 Phased electric rate increase filings. (a...

  1. 22 CFR 218.23 - Self-evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... written self-evaluation of its compliance under the act within 18 months of the effective date of these... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Self-evaluation. 218.23 Section 218.23 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 218.23 Self-evaluation....

  2. 50 CFR 218.35 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Applications for Letters of Authorization. 218.35 Section 218.35 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND... Range Complex § 218.35 Applications for Letters of Authorization. To incidentally take marine mammals...

  3. 49 CFR 384.218 - Second serious traffic violation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Second serious traffic violation. 384.218 Section 384.218 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... § 384.218 Second serious traffic violation. The State must disqualify from operating a CMV for a...

  4. 49 CFR 384.218 - Second serious traffic violation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Second serious traffic violation. 384.218 Section 384.218 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... § 384.218 Second serious traffic violation. The State must disqualify from operating a CMV for a...

  5. 49 CFR 384.218 - Second serious traffic violation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Second serious traffic violation. 384.218 Section 384.218 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... § 384.218 Second serious traffic violation. The State must disqualify from operating a CMV for a...

  6. 49 CFR 384.218 - Second serious traffic violation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Second serious traffic violation. 384.218 Section 384.218 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... § 384.218 Second serious traffic violation. The State must disqualify from operating a CMV for a...

  7. 49 CFR 384.218 - Second serious traffic violation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Second serious traffic violation. 384.218 Section 384.218 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... § 384.218 Second serious traffic violation. The State must disqualify from operating a CMV for a...

  8. 14 CFR 21.8 - Approval of articles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to...

  9. 14 CFR 21.8 - Approval of articles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to...

  10. 14 CFR 21.8 - Approval of articles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to...

  11. 14 CFR 21.8 - Approval of articles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to...

  12. 14 CFR 21.8 - Approval of articles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to...

  13. 49 CFR 218.30 - Remotely controlled switches.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Remotely controlled switches. 218.30 Section 218....30 Remotely controlled switches. (a) After the operator of the remotely controlled switches has received the notification required by § 218.27(c), he must line each remotely controlled switch...

  14. 49 CFR 218.30 - Remotely controlled switches.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Remotely controlled switches. 218.30 Section 218....30 Remotely controlled switches. (a) After the operator of the remotely controlled switches has received the notification required by § 218.27(c), he must line each remotely controlled switch...

  15. 20 CFR 218.15 - When a parent annuity begins.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true When a parent annuity begins. 218.15 Section 218.15 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.15 When a parent annuity begins. A...

  16. 20 CFR 218.15 - When a parent annuity begins.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false When a parent annuity begins. 218.15 Section 218.15 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.15 When a parent annuity begins. A...

  17. 20 CFR 218.42 - When a parent annuity ends.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true When a parent annuity ends. 218.42 Section 218... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.42 When a parent annuity ends. (a) Tier I. The tier I benefit of a parent annuity ends with the earliest of the last day of the month before...

  18. 20 CFR 218.15 - When a parent annuity begins.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true When a parent annuity begins. 218.15 Section 218.15 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.15 When a parent annuity begins. A...

  19. 20 CFR 218.15 - When a parent annuity begins.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false When a parent annuity begins. 218.15 Section 218.15 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.15 When a parent annuity begins. A...

  20. 20 CFR 218.42 - When a parent annuity ends.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true When a parent annuity ends. 218.42 Section 218... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.42 When a parent annuity ends. (a) Tier I. The tier I benefit of a parent annuity ends with the earliest of the last day of the month before...

  1. 20 CFR 218.15 - When a parent annuity begins.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a parent annuity begins. 218.15 Section 218.15 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.15 When a parent annuity begins. A...

  2. 41 CFR 101-29.218 - Voluntary standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Voluntary standards. 101-29.218 Section 101-29.218 Public Contracts and Property Management Federal Property Management... DESCRIPTIONS 29.2-Definitions § 101-29.218 Voluntary standards. Voluntary standards are established generally...

  3. 41 CFR 101-29.218 - Voluntary standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Voluntary standards. 101-29.218 Section 101-29.218 Public Contracts and Property Management Federal Property Management... DESCRIPTIONS 29.2-Definitions § 101-29.218 Voluntary standards. Voluntary standards are established generally...

  4. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Hand-operated fixed derails. 218.109 Section 218.109 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Derails § 218.109 Hand-operated fixed derails. (a)(1) Each railroad shall adopt and comply with...

  5. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Hand-operated fixed derails. 218.109 Section 218.109 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Derails § 218.109 Hand-operated fixed derails. (a)(1) Each railroad shall adopt and comply with...

  6. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Hand-operated fixed derails. 218.109 Section 218.109 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Derails § 218.109 Hand-operated fixed derails. (a)(1) Each railroad shall adopt and comply with...

  7. 10 CFR 218.2 - Activation/Deactivation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Activation/Deactivation. 218.2 Section 218.2 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.2 Activation/Deactivation. (a) This rule shall take effect providing: (1) The International Energy Program has been...

  8. 10 CFR 218.2 - Activation/Deactivation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Activation/Deactivation. 218.2 Section 218.2 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.2 Activation/Deactivation. (a) This rule shall take effect providing: (1) The International Energy Program has been...

  9. 10 CFR 218.2 - Activation/Deactivation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Activation/Deactivation. 218.2 Section 218.2 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.2 Activation/Deactivation. (a) This rule shall take effect providing: (1) The International Energy Program has been...

  10. 10 CFR 218.2 - Activation/Deactivation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Activation/Deactivation. 218.2 Section 218.2 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.2 Activation/Deactivation. (a) This rule shall take effect providing: (1) The International Energy Program has been...

  11. 10 CFR 218.2 - Activation/Deactivation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Activation/Deactivation. 218.2 Section 218.2 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION General Provisions § 218.2 Activation/Deactivation. (a) This rule shall take effect providing: (1) The International Energy Program has been...

  12. 22 CFR 218.22 - Notice to subrecipients.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Notice to subrecipients. 218.22 Section 218.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 218.22 Notice to...

  13. 22 CFR 218.22 - Notice to subrecipients.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Notice to subrecipients. 218.22 Section 218.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 218.22 Notice to...

  14. 22 CFR 218.22 - Notice to subrecipients.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Notice to subrecipients. 218.22 Section 218.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 218.22 Notice to...

  15. 22 CFR 218.22 - Notice to subrecipients.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Notice to subrecipients. 218.22 Section 218.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 218.22 Notice to...

  16. 22 CFR 218.22 - Notice to subrecipients.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Notice to subrecipients. 218.22 Section 218.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 218.22 Notice to...

  17. 49 CFR 218.30 - Remotely controlled switches.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Remotely controlled switches. 218.30 Section 218....30 Remotely controlled switches. (a) After the operator of the remotely controlled switches has received the notification required by § 218.27(c), he must line each remotely controlled switch...

  18. 49 CFR 218.30 - Remotely controlled switches.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Remotely controlled switches. 218.30 Section 218....30 Remotely controlled switches. (a) After the operator of the remotely controlled switches has received the notification required by § 218.27(c), he must line each remotely controlled switch...

  19. 49 CFR 218.30 - Remotely controlled switches.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Remotely controlled switches. 218.30 Section 218....30 Remotely controlled switches. (a) After the operator of the remotely controlled switches has received the notification required by § 218.27(c), he must line each remotely controlled switch...

  20. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  1. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  2. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  3. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  4. 48 CFR 218.170 - Additional acquisition flexibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Additional acquisition flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Acquisition Flexibilities 218.170 Additional acquisition flexibilities. Additional acquisition...

  5. 10 CFR 72.218 - Termination of licenses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Termination of licenses. 72.218 Section 72.218 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT... for Storage of Spent Fuel at Power Reactor Sites § 72.218 Termination of licenses. (a) The...

  6. 10 CFR 72.218 - Termination of licenses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Termination of licenses. 72.218 Section 72.218 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT... for Storage of Spent Fuel at Power Reactor Sites § 72.218 Termination of licenses. (a) The...

  7. 10 CFR 72.218 - Termination of licenses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Termination of licenses. 72.218 Section 72.218 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT... for Storage of Spent Fuel at Power Reactor Sites § 72.218 Termination of licenses. (a) The...

  8. 30 CFR 218.201 - Method of payment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Method of payment. 218.201 Section 218.201 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Solid Minerals-General § 218.201...

  9. 5 CFR 179.218 - Additional administrative collection action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Additional administrative collection action. 179.218 Section 179.218 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.218 Additional administrative collection action...

  10. 49 CFR 218.99 - Shoving or pushing movements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Shoving or pushing movements. 218.99 Section 218... Derails § 218.99 Shoving or pushing movements. (a)(1) Each railroad shall adopt and comply with an... violated the requirements of this section. (2) The following requirements for shoving or pushing movements...

  11. 49 CFR 218.73 - Warning signal display.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Warning signal display. 218.73 Section 218.73 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.73...

  12. 49 CFR 218.71 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Purpose and scope. 218.71 Section 218.71 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.71...

  13. 49 CFR 218.80 - Movement of occupied camp cars.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Movement of occupied camp cars. 218.80 Section 218... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.80 Movement of occupied camp cars. Occupied cars may not be humped or flat switched unless coupled...

  14. 49 CFR 218.80 - Movement of occupied camp cars.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Movement of occupied camp cars. 218.80 Section 218... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.80 Movement of occupied camp cars. Occupied cars may not be humped or flat switched unless coupled...

  15. 49 CFR 218.80 - Movement of occupied camp cars.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Movement of occupied camp cars. 218.80 Section 218... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.80 Movement of occupied camp cars. Occupied cars may not be humped or flat switched unless coupled...

  16. 49 CFR 218.80 - Movement of occupied camp cars.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Movement of occupied camp cars. 218.80 Section 218... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.80 Movement of occupied camp cars. Occupied cars may not be humped or flat switched unless coupled...

  17. 7 CFR 65.218 - Pre-labeled.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Pre-labeled. 65.218 Section 65.218 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.218 Pre-labeled. Pre-labeled means a...

  18. 7 CFR 65.218 - Pre-labeled.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Pre-labeled. 65.218 Section 65.218 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.218 Pre-labeled. Pre-labeled means a...

  19. 7 CFR 65.218 - Pre-labeled.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Pre-labeled. 65.218 Section 65.218 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.218 Pre-labeled. Pre-labeled means a...

  20. 7 CFR 65.218 - Pre-labeled.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Pre-labeled. 65.218 Section 65.218 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.218 Pre-labeled. Pre-labeled means a...

  1. 7 CFR 65.218 - Pre-labeled.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Pre-labeled. 65.218 Section 65.218 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.218 Pre-labeled. Pre-labeled means a...

  2. 20 CFR 218.41 - When a child annuity ends.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true When a child annuity ends. 218.41 Section 218... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.41 When a child annuity ends. A child annuity ends with the earliest of— (a) The last day of the month before the month in which the...

  3. 20 CFR 218.41 - When a child annuity ends.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true When a child annuity ends. 218.41 Section 218... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.41 When a child annuity ends. A child annuity ends with the earliest of— (a) The last day of the month before the month in which the...

  4. 20 CFR 218.41 - When a child annuity ends.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a child annuity ends. 218.41 Section 218... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.41 When a child annuity ends. A child annuity ends with the earliest of— (a) The last day of the month before the month in which the...

  5. 20 CFR 218.41 - When a child annuity ends.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false When a child annuity ends. 218.41 Section 218... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.41 When a child annuity ends. A child annuity ends with the earliest of— (a) The last day of the month before the month in which the...

  6. 36 CFR 218.9 - Objections set aside from review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Reduction Projects Authorized by the Healthy Forests Restoration Act of 2003 § 218.9 Objections set aside...)). (2) The proposed project is not subject to the objection procedures of this subpart (§§ 218.3, 218.4... illegible for any reason, including submissions in an electronic format different from that specified in the...

  7. [Hanover intensive score. Study on 218 cases ].

    PubMed

    Dorobăţ, G; Dorobăţ, C M; Luca, V

    2000-01-01

    We have performed a prospective study (1990-1996) in our intensive care unit in Hospital "C.I. Parhon" Iassy. Our study has 218 critical patients with ARDS and MSOD. For all of them we have used a new scoring system HIS (Hanover Intensive Score) for: the evaluation of patients with ARDS that have the risk to develop MSOD; determine the prognosis in different moments of evolution. In our opinion this score has the following advantages: it is easy to apply; it can determine the prognosis and the probable status of the patient at the moment of outcome; it can be used in our country with the technical that we have and we propose this score for his performances.

  8. Kinetics of neutralization of Po-218

    SciTech Connect

    Chu, K.D.

    1987-01-01

    In a well-defined experimental system the neutralization of polonium-218 ions was investigated as a function of the physical and chemical properties of the controlled composition atmosphere. The mobilities of Po/sup +/ and PoO/sub 2//sup +/ are determined by combining experimental results with a computer model of the system. Three neutralization mechanisms were individually studied. The small ion recombination rate has been found to be proportional to the square root of radon concentration. The electron scavenging mechanism is responsible for the neutralization of Po/sup +/ in NO/sub 2/ or H/sub 2/O in nitrogen. When PoO/sub 2//sup +/ is formed, the electron transfer mechanism dominates the neutralization process. The electron is transferred to PoO/sub 2//sup +/ from molecules with lower ionization potentials. The ionization potential of PoO/sub 2//sup +/ is also determined to be 10.44 +/- 0.05 eV.

  9. 50 CFR 300.218 - Reporting and recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... § 300.17(a) and (b). (vi) Canada albacore fisheries. Fishing activities subject to the reporting... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Reporting and recordkeeping requirements. 300.218 Section 300.218 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES...

  10. 50 CFR 300.218 - Reporting and recordkeeping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... § 300.17(a) and (b). (vi) Canada albacore fisheries. Fishing activities subject to the reporting... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Reporting and recordkeeping requirements. 300.218 Section 300.218 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES...

  11. 50 CFR 300.218 - Reporting and recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 300.17(a) and (b). (vi) Canada albacore fisheries. Fishing activities subject to the reporting... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Reporting and recordkeeping requirements. 300.218 Section 300.218 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES...

  12. 50 CFR 300.218 - Reporting and recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 300.17(a) and (b). (vi) Canada albacore fisheries. Fishing activities subject to the reporting... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Reporting and recordkeeping requirements. 300.218 Section 300.218 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES...

  13. 50 CFR 300.218 - Reporting and recordkeeping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... § 300.17(a) and (b). (vi) Canada albacore fisheries. Fishing activities subject to the reporting... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Reporting and recordkeeping requirements. 300.218 Section 300.218 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES...

  14. 40 CFR 86.218-94 - Dynamometer calibration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Dynamometer calibration. 86.218-94 Section 86.218-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... 1994 and Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium...

  15. 49 CFR 218.97 - Good faith challenge procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... normal business hours. (2) A copy of any written good faith challenge verification decision, made in... 49 Transportation 4 2010-10-01 2010-10-01 false Good faith challenge procedures. 218.97 Section... Derails § 218.97 Good faith challenge procedures. (a) Employee responsibility. An employee shall...

  16. 49 CFR 218.73 - Warning signal display.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Warning signal display. 218.73 Section 218.73... signal display. (a) Warning signals, i.e., a white disk with the words “Occupied Camp Car” in black lettering during daylight hours and an illuminated white signal at night, displayed in accordance with §...

  17. 49 CFR 218.73 - Warning signal display.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Warning signal display. 218.73 Section 218.73... signal display. (a) Warning signals, i.e., a white disk with the words “Occupied Camp Car” in black lettering during daylight hours and an illuminated white signal at night, displayed in accordance with §...

  18. 49 CFR 218.73 - Warning signal display.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Warning signal display. 218.73 Section 218.73... signal display. (a) Warning signals, i.e., a white disk with the words “Occupied Camp Car” in black lettering during daylight hours and an illuminated white signal at night, displayed in accordance with §...

  19. 49 CFR 218.73 - Warning signal display.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Warning signal display. 218.73 Section 218.73... signal display. (a) Warning signals, i.e., a white disk with the words “Occupied Camp Car” in black lettering during daylight hours and an illuminated white signal at night, displayed in accordance with §...

  20. 49 CFR 173.218 - Fish meal or fish scrap.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Fish meal or fish scrap. 173.218 Section 173.218... Fish meal or fish scrap. (a) Except as provided in Column (7) of the HMT in § 172.101 of this subchapter, fish meal or fish scrap, containing at least 6%, but not more than 12% water, is authorized...

  1. 49 CFR 218.99 - Shoving or pushing movements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Shoving or pushing movements. 218.99 Section 218.99 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  2. 49 CFR 218.95 - Instruction, training, and examination.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Instruction, training, and examination. 218.95 Section 218.95 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  3. 49 CFR 218.95 - Instruction, training, and examination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Instruction, training, and examination. 218.95 Section 218.95 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  4. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Hand-operated fixed derails. 218.109 Section 218.109 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  5. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Hand-operated fixed derails. 218.109 Section 218.109 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  6. 49 CFR 218.77 - Remotely controlled switches.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Remotely controlled switches. 218.77 Section 218....77 Remotely controlled switches. (a) After the operator of the remotely controlled switch is notified that a camp car is to be placed on a particular track, he shall line such switch against movement...

  7. 49 CFR 218.77 - Remotely controlled switches.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Remotely controlled switches. 218.77 Section 218....77 Remotely controlled switches. (a) After the operator of the remotely controlled switch is notified that a camp car is to be placed on a particular track, he shall line such switch against movement...

  8. 49 CFR 218.79 - Alternative methods of protection.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 218.79 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218... cars are on track other than main track: (1) A warning signal must be displayed at or near each...

  9. 49 CFR 218.79 - Alternative methods of protection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 218.79 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218... cars are on track other than main track: (1) A warning signal must be displayed at or near each...

  10. 20 CFR 218.42 - When a parent annuity ends.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false When a parent annuity ends. 218.42 Section... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.42 When a parent annuity ends. (a) Tier I. The tier I benefit of a parent annuity ends with the earliest of the last day of the month before...

  11. 20 CFR 218.42 - When a parent annuity ends.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a parent annuity ends. 218.42 Section... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.42 When a parent annuity ends. (a) Tier I. The tier I benefit of a parent annuity ends with the earliest of the last day of the month before...

  12. 20 CFR 218.42 - When a parent annuity ends.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false When a parent annuity ends. 218.42 Section... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.42 When a parent annuity ends. (a) Tier I. The tier I benefit of a parent annuity ends with the earliest of the last day of the month before...

  13. 14 CFR 218.4 - Condition upon authority of lessee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... § 218.4 Condition upon authority of lessee. In any case where a foreign air carrier leases from another... performing foreign air transportation, it shall be a condition upon the authority of the lessee to perform... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Condition upon authority of lessee. 218.4...

  14. 49 CFR 218.59 - Responsibilities of railroads.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Responsibilities of railroads. 218.59 Section 218.59 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Prohibition Against Tampering...

  15. 49 CFR 218.59 - Responsibilities of railroads.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Responsibilities of railroads. 218.59 Section 218.59 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Prohibition Against Tampering...

  16. 49 CFR 218.59 - Responsibilities of railroads.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Responsibilities of railroads. 218.59 Section 218.59 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Prohibition Against Tampering...

  17. 28 CFR 115.218 - Upgrades to facilities and technologies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Upgrades to facilities and technologies. 115.218 Section 115.218 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE... residents from sexual abuse. (b) When installing or updating a video monitoring system,...

  18. 28 CFR 115.218 - Upgrades to facilities and technologies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Upgrades to facilities and technologies. 115.218 Section 115.218 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE... residents from sexual abuse. (b) When installing or updating a video monitoring system,...

  19. 28 CFR 115.218 - Upgrades to facilities and technologies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Upgrades to facilities and technologies. 115.218 Section 115.218 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE... residents from sexual abuse. (b) When installing or updating a video monitoring system,...

  20. 24 CFR 972.218 - Conversion assessment components.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Conversion assessment components. 972.218 Section 972.218 Housing and Urban Development Regulations Relating to Housing and Urban... URBAN DEVELOPMENT CONVERSION OF PUBLIC HOUSING TO TENANT-BASED ASSISTANCE Voluntary Conversion of...

  1. 49 CFR 218.24 - One-person crew.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false One-person crew. 218.24 Section 218.24...-person crew. (a) An engineer working alone as a one-person crew shall not perform duties on, under, or... unattended, the one-member crew shall secure the locomotive as follows: (i) The throttle is in the IDLE...

  2. 49 CFR 218.59 - Responsibilities of railroads.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Responsibilities of railroads. 218.59 Section 218.59 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Prohibition Against Tampering...

  3. 49 CFR 218.59 - Responsibilities of railroads.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Responsibilities of railroads. 218.59 Section 218.59 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Prohibition Against Tampering...

  4. 48 CFR 53.217-53.218 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false 53.217-53.218 Section 53.217-53.218 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms...

  5. 49 CFR 218.95 - Instruction, training, and examination.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Instruction, training, and examination. 218.95 Section 218.95 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  6. 49 CFR 218.99 - Shoving or pushing movements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Shoving or pushing movements. 218.99 Section 218.99 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  7. 49 CFR 218.99 - Shoving or pushing movements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Shoving or pushing movements. 218.99 Section 218.99 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  8. 49 CFR 218.77 - Remotely controlled switches.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Remotely controlled switches. 218.77 Section 218....77 Remotely controlled switches. (a) After the operator of the remotely controlled switch is notified that a camp car is to be placed on a particular track, he shall line such switch against movement...

  9. 49 CFR 218.99 - Shoving or pushing movements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Shoving or pushing movements. 218.99 Section 218.99 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  10. 49 CFR 218.95 - Instruction, training, and examination.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Instruction, training, and examination. 218.95 Section 218.95 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  11. 49 CFR 218.95 - Instruction, training, and examination.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Instruction, training, and examination. 218.95 Section 218.95 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and...

  12. 40 CFR 761.218 - Certificate of disposal.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 761.218 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.218 Certificate of disposal. (a) For each shipment of manifested PCB waste that the owner or operator of a disposal facility accepts by signing the manifest,...

  13. 40 CFR 761.218 - Certificate of disposal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 761.218 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.218 Certificate of disposal. (a) For each shipment of manifested PCB waste that the owner or operator of a disposal facility accepts by signing the manifest,...

  14. 40 CFR 761.218 - Certificate of disposal.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 761.218 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.218 Certificate of disposal. (a) For each shipment of manifested PCB waste that the owner or operator of a disposal facility accepts by signing the manifest,...

  15. 40 CFR 761.218 - Certificate of disposal.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 761.218 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.218 Certificate of disposal. (a) For each shipment of manifested PCB waste that the owner or operator of a disposal facility accepts by signing the manifest,...

  16. 24 CFR 200.218 - Who must certify and sign.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Who must certify and sign. 200.218... Previous Participation Review and Clearance Procedure § 200.218 Who must certify and sign. All principals must certify and sign the certificate personally as to their individual record and are responsible for...

  17. 24 CFR 200.218 - Who must certify and sign.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Who must certify and sign. 200.218... Previous Participation Review and Clearance Procedure § 200.218 Who must certify and sign. All principals must certify and sign the certificate personally as to their individual record and are responsible for...

  18. 24 CFR 200.218 - Who must certify and sign.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Who must certify and sign. 200.218... Previous Participation Review and Clearance Procedure § 200.218 Who must certify and sign. All principals must certify and sign the certificate personally as to their individual record and are responsible for...

  19. 24 CFR 200.218 - Who must certify and sign.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Who must certify and sign. 200.218... Previous Participation Review and Clearance Procedure § 200.218 Who must certify and sign. All principals must certify and sign the certificate personally as to their individual record and are responsible for...

  20. 24 CFR 200.218 - Who must certify and sign.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Who must certify and sign. 200.218... Previous Participation Review and Clearance Procedure § 200.218 Who must certify and sign. All principals must certify and sign the certificate personally as to their individual record and are responsible for...

  1. 30 CFR 218.302 - Late payment or underpayment charges.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Late payment or underpayment charges. 218.302 Section 218.302 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Geothermal...

  2. 30 CFR 218.55 - Interest payments to Indians.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Interest payments to Indians. 218.55 Section 218.55 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Oil and Gas,...

  3. 30 CFR 218.301 - Method of payment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Method of payment. 218.301 Section 218.301 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Geothermal Resources §...

  4. 30 CFR 218.100 - Royalty and rental payments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Royalty and rental payments. 218.100 Section 218.100 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Oil and Gas,...

  5. 30 CFR 218.103 - Payments to States.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Payments to States. 218.103 Section 218.103 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Oil and Gas, Onshore §...

  6. 49 CFR 218.80 - Movement of occupied camp cars.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Movement of occupied camp cars. 218.80 Section 218.80 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD....80 Movement of occupied camp cars. Occupied cars may not be humped or flat switched unless coupled to...

  7. 49 CFR 218.79 - Alternative methods of protection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Alternative methods of protection. 218.79 Section 218.79 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars §...

  8. 49 CFR 218.24 - One-person crew.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false One-person crew. 218.24 Section 218.24...-person crew. (a) An engineer working alone as a one-person crew shall not perform duties on, under, or... unattended, the one-member crew shall secure the locomotive as follows: (i) The throttle is in the...

  9. 20 CFR 218.14 - When a child annuity begins.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true When a child annuity begins. 218.14 Section... ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.14 When a child annuity begins. (a) A child annuity begins on the later of either the date chosen by the applicant or the earliest...

  10. 20 CFR 218.14 - When a child annuity begins.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false When a child annuity begins. 218.14 Section... ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.14 When a child annuity begins. (a) A child annuity begins on the later of either the date chosen by the applicant or the earliest...

  11. 20 CFR 218.14 - When a child annuity begins.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true When a child annuity begins. 218.14 Section... ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.14 When a child annuity begins. (a) A child annuity begins on the later of either the date chosen by the applicant or the earliest...

  12. 20 CFR 218.14 - When a child annuity begins.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a child annuity begins. 218.14 Section... ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.14 When a child annuity begins. (a) A child annuity begins on the later of either the date chosen by the applicant or the earliest...

  13. 18 CFR 157.218 - Changes in customer name.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Changes in customer name. 157.218 Section 157.218 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL...

  14. 18 CFR 157.218 - Changes in customer name.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Changes in customer name. 157.218 Section 157.218 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL...

  15. 18 CFR 157.218 - Changes in customer name.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Changes in customer name. 157.218 Section 157.218 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL...

  16. 18 CFR 157.218 - Changes in customer name.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Changes in customer name. 157.218 Section 157.218 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL...

  17. 18 CFR 157.218 - Changes in customer name.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Changes in customer name. 157.218 Section 157.218 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL...

  18. 29 CFR 825.218 - Substantial and grievous economic injury.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Substantial and grievous economic injury. 825.218 Section... Medical Leave Act § 825.218 Substantial and grievous economic injury. (a) In order to deny restoration to... cause “substantial and grievous economic injury” to the operations of the employer, not whether the...

  19. 29 CFR 825.218 - Substantial and grievous economic injury.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Substantial and grievous economic injury. 825.218 Section... Medical Leave Act § 825.218 Substantial and grievous economic injury. (a) In order to deny restoration to... cause “substantial and grievous economic injury” to the operations of the employer, not whether the...

  20. Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia.

    PubMed Central

    Hauck, M. L.; Larsen, R. H.; Welsh, P. C.; Zalutsky, M. R.

    1998-01-01

    The high linear energy transfer, alpha-particle-emitting radionuclide astatine-211 (211At) is of interest for certain therapeutic applications; however, because of the 55- to 70-microm path length of its alpha-particles, achieving homogeneous tracer distribution is critical. Hyperthermia may enhance the therapeutic efficacy of alpha-particle endoradiotherapy if it can improve tracer distribution. In this study, we have investigated whether hyperthermia increased the cytotoxicity of an 211At-labelled monoclonal antibody (MAb) in tumour spheroids with a radius (approximately 100 microm) greater than the range of 211At alpha-particles. Hyperthermia for 1 h at 42 degrees C was used because this treatment itself resulted in no regrowth delay. Radiolabelled chimeric MAb 81C6 reactive with the extracellular matrix antigen tenascin was added to spheroids grown from the D-247 MG human glioma cell line at activity concentrations ranging from 0.125 to 250 kBq ml(-1). A significant regrowth delay was observed at 125 and 250 kBq ml(-1) in both hyperthermia-treated and untreated spheroids. For groups receiving hyperthermia, no increase in cytotoxicity was seen compared with normothermic controls at any activity concentration. These results and those from autoradiographs indicate that hyperthermia at 42 degrees C for 1 h had no significant effect on the uptake or distribution of this antitenascin MAb in D-247 MG spheroids. Images Figure 4 Figure 5 PMID:9514054

  1. (211)Astatine-Conjugated Monoclonal CD45 Antibody-Based Nonmyeloablative Conditioning for Stem Cell Gene Therapy.

    PubMed

    Burtner, Christopher R; Chandrasekaran, Devikha; Santos, Erlinda B; Beard, Brian C; Adair, Jennifer E; Hamlin, Donald K; Wilbur, D Scott; Sandmaier, Brenda M; Kiem, Hans-Peter

    2015-06-01

    Most hematopoietic stem cell gene therapy studies require host conditioning to allow for efficient engraftment of gene-modified cells. Conditioning regimens with lower treatment-related toxicities are especially relevant for the treatment of nonmalignant blood disorders, such as hemoglobinopathies and immunodeficiencies, and for patients who are otherwise ineligible for conventional high-dose conditioning. Radioimmunotherapy, which employs an α- or a β-emitting radionuclide conjugated to a targeting antibody, is effective for delivering cytotoxic doses of radiation to a cell type of interest while minimizing off-target toxicity. Here, we demonstrate the feasibility of using a nonmyeloablative dose of a monoclonal anti-CD45 antibody conjugated to the α-emitter Astatine-211 ((211)At) to promote engraftment of an autologous gene-modified stem cell graft in the canine model. The doses used provided myelosuppression with rapid autologous recovery and minimal off-target toxicity. Engraftment levels were low in all dogs and reflected the low numbers of gene-modified cells infused. Our data suggest that a cell dose exceeding 1×10(6) cells/kg be used with nonmyeloablative doses of (211)At-anti-CD45 monoclonal antibodies for sustained engraftment in the dog model.

  2. Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia.

    PubMed

    Hauck, M L; Larsen, R H; Welsh, P C; Zalutsky, M R

    1998-03-01

    The high linear energy transfer, alpha-particle-emitting radionuclide astatine-211 (211At) is of interest for certain therapeutic applications; however, because of the 55- to 70-microm path length of its alpha-particles, achieving homogeneous tracer distribution is critical. Hyperthermia may enhance the therapeutic efficacy of alpha-particle endoradiotherapy if it can improve tracer distribution. In this study, we have investigated whether hyperthermia increased the cytotoxicity of an 211At-labelled monoclonal antibody (MAb) in tumour spheroids with a radius (approximately 100 microm) greater than the range of 211At alpha-particles. Hyperthermia for 1 h at 42 degrees C was used because this treatment itself resulted in no regrowth delay. Radiolabelled chimeric MAb 81C6 reactive with the extracellular matrix antigen tenascin was added to spheroids grown from the D-247 MG human glioma cell line at activity concentrations ranging from 0.125 to 250 kBq ml(-1). A significant regrowth delay was observed at 125 and 250 kBq ml(-1) in both hyperthermia-treated and untreated spheroids. For groups receiving hyperthermia, no increase in cytotoxicity was seen compared with normothermic controls at any activity concentration. These results and those from autoradiographs indicate that hyperthermia at 42 degrees C for 1 h had no significant effect on the uptake or distribution of this antitenascin MAb in D-247 MG spheroids.

  3. Cell growth kinetics of the human cell line Colo-205 irradiated with photons and astatine-211 alpha-particles.

    PubMed

    Palm, S; Andersson, H; Bäck, T; Claesson, I; Delle, U; Hultborn, R; Jacobsson, L; Köpf, I; Lindegren, S

    2000-01-01

    Cell growth kinetics following Astatine-211 (211At, alpha-particle emitter) and photon irradiation were studied for the human colorectal cell line Colo-205. A growth assay using 96-well plates was chosen. The growth kinetics could be simulated by assuming certain fractions of cells with various proliferative capacities, i.e. from none up to 5 cell doublings, in addition to the defined survivors with remaining unlimited clonogenic capacity. No significant difference in cell growth characteristics was seen between 211At and photon irradiation. The cell doubling time, as calculated from the increment in optical density, was compared with the results from BrdU experiments in the early phases of growth (Tpot = 18.5 +/- 0.6 h for LDR (low dose rate) photon irradiated and 20.3 +/- 0.8 hours for sham-irradiated cells 40-45 hours post-irradiation) confirming the transient accelerated growth of irradiated cells. No statistically significant difference in growth was found between LDR, MDR (medium dose rate) and HDR (high dose rate) photon irradiation.

  4. 211Astatine-Conjugated Monoclonal CD45 Antibody-Based Nonmyeloablative Conditioning for Stem Cell Gene Therapy

    PubMed Central

    Burtner, Christopher R.; Chandrasekaran, Devikha; Santos, Erlinda B.; Beard, Brian C.; Adair, Jennifer E.; Hamlin, Donald K.; Wilbur, D. Scott; Sandmaier, Brenda M.

    2015-01-01

    Abstract Most hematopoietic stem cell gene therapy studies require host conditioning to allow for efficient engraftment of gene-modified cells. Conditioning regimens with lower treatment-related toxicities are especially relevant for the treatment of nonmalignant blood disorders, such as hemoglobinopathies and immunodeficiencies, and for patients who are otherwise ineligible for conventional high-dose conditioning. Radioimmunotherapy, which employs an α- or a β-emitting radionuclide conjugated to a targeting antibody, is effective for delivering cytotoxic doses of radiation to a cell type of interest while minimizing off-target toxicity. Here, we demonstrate the feasibility of using a nonmyeloablative dose of a monoclonal anti-CD45 antibody conjugated to the α-emitter Astatine-211 (211At) to promote engraftment of an autologous gene-modified stem cell graft in the canine model. The doses used provided myelosuppression with rapid autologous recovery and minimal off-target toxicity. Engraftment levels were low in all dogs and reflected the low numbers of gene-modified cells infused. Our data suggest that a cell dose exceeding 1×106 cells/kg be used with nonmyeloablative doses of 211At-anti-CD45 monoclonal antibodies for sustained engraftment in the dog model. PMID:25919226

  5. 50 CFR 218.126 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND...) conducting the activity identified in § 218.120(c) (i.e., the Navy) must apply for and obtain either...

  6. 50 CFR 218.106 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND... identified in § 218.100(c) (i.e., the Navy) must apply for and obtain either an initial Letter...

  7. 50 CFR 218.116 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND... identified in § 218.110(c) (i.e., the Navy) must apply for and obtain either an initial Letter...

  8. 50 CFR 218.188 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.188 Modifications to Letters of Authorization....

  9. 50 CFR 218.188 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.188 Modifications to Letters of Authorization....

  10. 50 CFR 218.185 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.185 Applications for Letters of Authorization....

  11. 50 CFR 218.188 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.188 Modifications to Letters of Authorization....

  12. 50 CFR 218.188 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.188 Modifications to Letters of Authorization....

  13. 50 CFR 218.185 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.185 Applications for Letters of Authorization....

  14. 50 CFR 218.185 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.185 Applications for Letters of Authorization....

  15. 50 CFR 218.185 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to U.S. Navy Mission Activities in the Naval Surface Warfare Center Panama City Division § 218.185 Applications for Letters of Authorization....

  16. 4. INTERIOR VIEW NORTHWEST, ALLEYWAY PASSAGE BETWEEN 216 AND 218 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. INTERIOR VIEW NORTHWEST, ALLEYWAY PASSAGE BETWEEN 216 AND 218 KING STREET SHOWING MASONRY ARCHED CONSTRUCTION SUPPORTING UPPER STORIES - King Street, 200 Block, 216 King Street (Commercial Building), Wilmington, New Castle County, DE

  17. 50 CFR 218.16 - Letters of Authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MAMMALS Taking Marine Mammals Incidental to U.S. Navy Training in the Jacksonville Range Complex (JAX Range Complex) § 218.16 Letters of Authorization. (a) A Letter of Authorization, unless suspended...

  18. 50 CFR 218.7 - Letters of Authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MAMMALS Taking Marine Mammals Incidental to U.S. Navy Training in the Virginia Capes Range Complex (VACAPES Range Complex) § 218.7 Letters of Authorization. (a) A Letter of Authorization, unless...

  19. 50 CFR 218.175 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.175 Applications for Letters of...

  20. 50 CFR 218.178 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.178 Modifications to Letters of...

  1. 50 CFR 218.175 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.175 Applications for Letters of...

  2. 50 CFR 218.176 - Letters of Authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.176 Letters of Authorization. (a) A Letter...

  3. 50 CFR 218.178 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.178 Modifications to Letters of...

  4. 50 CFR 218.178 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.178 Modifications to Letters of...

  5. 50 CFR 218.175 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.175 Applications for Letters of...

  6. 50 CFR 218.178 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.178 Modifications to Letters of...

  7. 50 CFR 218.176 - Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.176 Letters of Authorization. (a) A Letter...

  8. 50 CFR 218.175 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Evaluation Activities in the Naval Sea System Command (NAVSEA) Naval Undersea Warfare Center (NUWC) Keyport Range Complex and the Associated Proposed Extensions Study Area § 218.175 Applications for Letters of...

  9. 36 CFR 218.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Authorized by the Healthy Forests Restoration Act of 2003 § 218.1 Purpose and scope. This subpart establishes... authorized hazardous fuel reduction projects as defined in the Healthy Forests Restoration Act of 2003 (HFRA...

  10. 36 CFR 218.30 - Applicability and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Authorized Under the Healthy Forests Restoration Act § 218.30 Applicability and scope. This subpart includes... Decision or Decision Notice, and authorized under the Healthy Forests Restoration Act (HFRA). The sections...

  11. 36 CFR 218.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Authorized by the Healthy Forests Restoration Act of 2003 § 218.1 Purpose and scope. This subpart establishes... authorized hazardous fuel reduction projects as defined in the Healthy Forests Restoration Act of 2003 (HFRA...

  12. 36 CFR 218.20 - Applicability and scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Not Authorized Under Healthy Forests Restoration Act § 218.20 Applicability and scope. This subpart... the Healthy Forests Restoration Act (HFRA). The sections of this subpart must be considered in...

  13. 36 CFR 218.30 - Applicability and scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Authorized Under the Healthy Forests Restoration Act § 218.30 Applicability and scope. This subpart includes... Decision or Decision Notice, and authorized under the Healthy Forests Restoration Act (HFRA). The sections...

  14. 36 CFR 218.1 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Authorized by the Healthy Forests Restoration Act of 2003 § 218.1 Purpose and scope. This subpart establishes... authorized hazardous fuel reduction projects as defined in the Healthy Forests Restoration Act of 2003 (HFRA...

  15. 36 CFR 218.20 - Applicability and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Not Authorized Under Healthy Forests Restoration Act § 218.20 Applicability and scope. This subpart... the Healthy Forests Restoration Act (HFRA). The sections of this subpart must be considered in...

  16. 50 CFR 218.240 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.240 Modifications to Letters of... sonar system from one ship to another, is not considered a substantial modification. (b) If...

  17. 50 CFR 218.237 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.237 Applications for Letters of... scheduled to begin conducting SURTASS LFA sonar operations or the previous Letter of Authorization...

  18. 50 CFR 218.240 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.240 Modifications to Letters of... sonar system from one ship to another, is not considered a substantial modification. (b) If...

  19. 50 CFR 218.232 - Permissible methods of taking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Low Frequency Active (SURTASS LFA) Sonar § 218.232 Permissible methods of taking. (a) Under Letters of.... This annual per-stock cap of 12 percent applies regardless of the number of SURTASS LFA sonar...

  20. 50 CFR 218.232 - Permissible methods of taking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Low Frequency Active (SURTASS LFA) Sonar § 218.232 Permissible methods of taking. (a) Under Letters of.... This annual per-stock cap of 12 percent applies regardless of the number of SURTASS LFA sonar...

  1. 50 CFR 218.240 - Modifications to Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.240 Modifications to Letters of... sonar system from one ship to another, is not considered a substantial modification. (b) If...

  2. 50 CFR 218.237 - Applications for Letters of Authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.237 Applications for Letters of... scheduled to begin conducting SURTASS LFA sonar operations or the previous Letter of Authorization...

  3. 50 CFR 218.232 - Permissible methods of taking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Low Frequency Active (SURTASS LFA) Sonar § 218.232 Permissible methods of taking. (a) Under Letters of.... This annual per-stock cap of 12 percent applies regardless of the number of SURTASS LFA sonar...

  4. 50 CFR 218.239 - Renewal of Letters of Authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.239 Renewal of Letters of.... Amending the areas for upcoming SURTASS LFA sonar operations is not considered a substantial modification...

  5. 50 CFR 218.239 - Renewal of Letters of Authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.239 Renewal of Letters of.... Amending the areas for upcoming SURTASS LFA sonar operations is not considered a substantial modification...

  6. 50 CFR 218.239 - Renewal of Letters of Authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Array Sensor System Low Frequency Active (SURTASS LFA) Sonar § 218.239 Renewal of Letters of.... Amending the areas for upcoming SURTASS LFA sonar operations is not considered a substantial modification...

  7. 3. ELEVATION VIEW OF THE SOUTH FACADE OF BUILDING 218, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. ELEVATION VIEW OF THE SOUTH FACADE OF BUILDING 218, LOOKING WEST-NORTHWEST. - Mill Valley Air Force Station, Consolidated Open Mess, East Ridgecrest Boulevard, Mount Tamalpais, Mill Valley, Marin County, CA

  8. 36 CFR 218.10 - Objection time periods and process.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Hazardous Fuel Reduction Projects Authorized by the Healthy Forests Restoration Act of 2003 § 218.10... calendar day (11:59 p.m. in the time zone of the receiving office) for objections filed by electronic means...

  9. Stability and in vivo behavior of Rh[16aneS4-diol]211At complex: a potential precursor for astatine radiopharmaceuticals

    PubMed Central

    Pruszynski, Marek; Łyczko, Monika; Bilewicz, Aleksander; Zalutsky, Michael R.

    2015-01-01

    Introduction The heavy halogen 211At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other 211At labeling strategies. One relatively unexplored approach is to utilize prosthetic groups based on astatinated rhodium(III) complex stabilized with a tetrathioether macrocyclic ligand - Rh[16aneS4-diol]211At. The purpose of the current study was to evaluate the in vitro and in vivo stability of this complex in comparison to its iodine analogue - Rh[16aneS4-diol]131I. Methods Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I complexes were synthesized and purified by HPLC. The stability of both complexes was evaluated in vitro by incubation in phosphate-buffered saline (PBS) and human serum at different temperatures. The in vivo behavior of the two radiohalogenated complexes was assessed by a paired-label biodistribution study in normal Balb/c mice. Results Both complexes were synthesized in high yield and purity. Almost no degradation was observed for Rh[16aneS4-diol]131I in PBS over a 72 h incubation. The astatinated analogue exhibited good stability in PBS over 14 h. A slow decline in the percentage of intact complex was observed for both tracers in human serum. In the biodistribution study, retention of 211At in most tissues was higher than that of 131I at all time points, especially in spleen and lungs. Renal clearance of Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I predominated, with 84.1 ± 2.3% and 94.6 ± 0.9% of injected dose excreted via the urine at 4 h. Conclusions The Rh[16aneS4-diol]211At complex might be useful for constructing prosthetic groups for the astatination of biomolecules and further studies are planned to evaluate this possibility. PMID:25687450

  10. Stability and in vivo behavior of Rh[16aneS4-diol]211 at complex: a potential precursor for astatine radiopharmaceuticals.

    PubMed

    Pruszyński, Marek; Łyczko, Monika; Bilewicz, Aleksander; Zalutsky, Michael R

    2015-05-01

    The heavy halogen (211)At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other (211)At labeling strategies. One relatively unexplored approach is to utilize prosthetic groups based on astatinated rhodium (III) complex stabilized with a tetrathioether macrocyclic ligand - Rh[16aneS(4)-diol](211)At. The purpose of the current study was to evaluate the in vitro and in vivo stability of this complex in comparison to its iodine analog - Rh[16aneS(4)-diol](131)I. Rh[16aneS(4)-diol](211)At and Rh[16aneS(4)-diol](131)I complexes were synthesized and purified by HPLC. The stability of both complexes was evaluated in vitro by incubation in phosphate-buffered saline (PBS) and human serum at different temperatures. The in vivo behavior of the two radiohalogenated complexes was assessed by a paired-label biodistribution study in normal Balb/c mice. Both complexes were synthesized in high yield and purity. Almost no degradation was observed for Rh[16aneS(4)-diol](131)I in PBS over a 72 h incubation. The astatinated analog exhibited good stability in PBS over 14 h. A slow decline in the percentage of intact complex was observed for both tracers in human serum. In the biodistribution study, retention of (211)At in most tissues was higher than that of (131)I at all time points, especially in spleen and lungs. Renal clearance of Rh[16aneS(4)-diol](211)At and Rh[16aneS(4)-diol](131)I predominated, with 84.1 ± 2.3% and 94.6 ± 0.9% of injected dose excreted via the urine at 4 h. The Rh[16aneS(4)-diol](211)At complex might be useful for constructing prosthetic groups for the astatination of biomolecules and further studies are planned to evaluate this possibility. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Single-cell irradiation from [211At] astatine-labeled C215 monoclonal antibody: improved estimates of radiosensitivity from measurements on cellular uptake and retention.

    PubMed

    Palm, Stig; Bäck, Tom; Claesson, Ingela; Delle, Ulla; Hultborn, Ragnar; Lindegren, Sture; Jacobsson, Lars

    2003-01-01

    New data on the biological effect of 211At-C215 monoclonal antibody in a slowly rotating, widely dispersed single-cell suspension of the human cancer cell line Colo-205 is presented. Cell growth curves of each experiment were used to calculate an apparent cell survival after irradiation. Uptake measurements provided the data needed to calculate the average number of 211At decays per cell in the cell suspension. The results from each experiment were then fit to a mono-exponential function. From the exponential fit, an average of 35 +/- 2 (SD) astatine-211 decays per cell are required for 37% apparent cell survival (D0).

  12. Alternating parity structure in doubly odd /sup 218/Ac

    SciTech Connect

    Debray, M.E.; Davidson, M.; Kreiner, A.J.; Davidson, J.; Falcone, G.; Hojman, D.; Santos, D.

    1989-03-01

    States in doubly odd /sup 218/Ac have been studied using in-beam ..cap alpha..-, ..gamma..-, and e/sup -/-spectroscopy techniques mainly through the /sup 209/Bi(/sup 12/C,3n)= fusion-evaporation reaction. /sup 218/Ac shows a band structure, with interleaved states of alternating parities connected by enhanced B(E1) transitions, which is strikingly similar to the one in its isotone /sup 217/Ra.

  13. 49 CFR 173.218 - Fish meal or fish scrap.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Fish meal or fish scrap. 173.218 Section 173.218... Fish meal or fish scrap. (a) Except as provided in Column (7) of the HMT in § 172.101 of this subchapter, fish meal or fish scrap, containing at least 6%, but not more than 12% water, is authorized for...

  14. Advances on the Determination of the Astatine Pourbaix Diagram: Predomination of AtO(OH)2 (-) over At(-) in Basic Conditions.

    PubMed

    Sergentu, Dumitru-Claudiu; Teze, David; Sabatié-Gogova, Andréa; Alliot, Cyrille; Guo, Ning; Bassal, Fadel; Silva, Isidro Da; Deniaud, David; Maurice, Rémi; Champion, Julie; Galland, Nicolas; Montavon, Gilles

    2016-02-24

    It is generally assumed that astatide (At(-) ) is the predominant astatine species in basic aqueous media. This assumption is questioned in non-complexing and non-reductive aqueous solutions by means of high-pressure anion-exchange chromatography. Contrary to what is usually believed, astatide is found to be a minor species at pH=11. A different species, which also bears a single negative charge, becomes predominant when the pH is increased beyond 7. Using competition experiments, an equilibrium constant value of 10(-6.9) has been determined for the formation of this species from AtO(OH) with the exchange of one proton. The identification of this species, AtO(OH)2 (-) , is achieved through relativistic quantum mechanical calculations, which rule out the significant formation of the AtO2 (-) species, while leading to a hydrolysis constant of AtO(OH) in excellent agreement with experiment when the AtO(OH)2 (-) species is considered. Beyond the completion of the Pourbaix diagram of astatine, this new information is of interest for the development of (211) At radiolabeling protocols. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    SciTech Connect

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  16. 20 CFR 218.30 - Separation, displacement or dismissal allowance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Separation, displacement or dismissal..., Spouse, or Divorced Spouse Annuity Beginning Date § 218.30 Separation, displacement or dismissal allowance. (a) General. When an employee receives a separation, displacement or dismissal allowance from...

  17. 20 CFR 218.30 - Separation, displacement or dismissal allowance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Separation, displacement or dismissal..., Spouse, or Divorced Spouse Annuity Beginning Date § 218.30 Separation, displacement or dismissal allowance. (a) General. When an employee receives a separation, displacement or dismissal allowance from...

  18. 20 CFR 218.30 - Separation, displacement or dismissal allowance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Separation, displacement or dismissal..., Spouse, or Divorced Spouse Annuity Beginning Date § 218.30 Separation, displacement or dismissal allowance. (a) General. When an employee receives a separation, displacement or dismissal allowance from...

  19. 20 CFR 218.30 - Separation, displacement or dismissal allowance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Separation, displacement or dismissal..., Spouse, or Divorced Spouse Annuity Beginning Date § 218.30 Separation, displacement or dismissal allowance. (a) General. When an employee receives a separation, displacement or dismissal allowance from...

  20. 10 CFR 72.218 - Termination of licenses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General License for Storage of Spent Fuel at Power Reactor Sites § 72.218 Termination of licenses. (a) The notification regarding the program for the management of spent fuel at the reactor required by § 50.54(bb)...

  1. 10 CFR 72.218 - Termination of licenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General License for Storage of Spent Fuel at Power Reactor Sites § 72.218 Termination of licenses. (a) The notification regarding the program for the management of spent fuel at the reactor required by § 50.54(bb)...

  2. 33 CFR 157.218 - Dedicated clean ballast tanks: Alterations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Dedicated clean ballast tanks... CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.218 Dedicated clean ballast tanks: Alterations. The dedicated clean ballast tanks or equipment on a tank vessel that has...

  3. 33 CFR 157.218 - Dedicated clean ballast tanks: Alterations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Dedicated clean ballast tanks... CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.218 Dedicated clean ballast tanks: Alterations. The dedicated clean ballast tanks or equipment on a tank vessel that has...

  4. 33 CFR 157.218 - Dedicated clean ballast tanks: Alterations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Dedicated clean ballast tanks... CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.218 Dedicated clean ballast tanks: Alterations. The dedicated clean ballast tanks or equipment on a tank vessel that has...

  5. 33 CFR 157.218 - Dedicated clean ballast tanks: Alterations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Dedicated clean ballast tanks... CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.218 Dedicated clean ballast tanks: Alterations. The dedicated clean ballast tanks or equipment on a tank vessel that has...

  6. 49 CFR 218.29 - Alternate methods of protection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... between rolling equipment in a car shop repair track area: (1) A blue signal must be displayed at or near... more cars coupled to a locomotive, and blue signals are not available, the engineman or operator at the... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Blue Signal Protection of Workers § 218...

  7. 48 CFR 218.271 - Head of contracting activity determinations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Head of contracting... Emergency Acquisition Flexibilities 218.271 Head of contracting activity determinations. For contract..., biological, chemical, or radiological attack, the term “head of the agency” is replaced with “head of...

  8. 48 CFR 218.270 - Head of contracting activity determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Head of contracting... Emergency Acquisition Flexibilities 218.270 Head of contracting activity determinations. For contract..., biological, chemical, or radiological attack, the term “head of the agency” is replaced with “head of...

  9. 48 CFR 218.271 - Head of contracting activity determinations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Head of contracting... Emergency Acquisition Flexibilities 218.271 Head of contracting activity determinations. For contract..., biological, chemical, or radiological attack, the term “head of the agency” is replaced with “head of...

  10. 48 CFR 218.271 - Head of contracting activity determinations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Head of contracting... Emergency Acquisition Flexibilities 218.271 Head of contracting activity determinations. For contract..., biological, chemical, or radiological attack, the term “head of the agency” is replaced with “head of...

  11. 48 CFR 218.271 - Head of contracting activity determinations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Head of contracting... Emergency Acquisition Flexibilities 218.271 Head of contracting activity determinations. For contract..., biological, chemical, or radiological attack, the term “head of the agency” is replaced with “head of...

  12. 37 CFR 2.18 - Correspondence, with whom held.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Correspondence, with whom... Persons § 2.18 Correspondence, with whom held. (a) Establishing the correspondence address. (1) If a... correspondence to the practitioner designated in the power. (2) If a practitioner qualified under § 11.14 of...

  13. 37 CFR 2.18 - Correspondence, with whom held.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Correspondence, with whom... Persons § 2.18 Correspondence, with whom held. (a) Establishing the correspondence address. (1) If a... correspondence to the practitioner designated in the power. (2) If a practitioner qualified under § 11.14 of...

  14. 37 CFR 2.18 - Correspondence, with whom held.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Correspondence, with whom... Persons § 2.18 Correspondence, with whom held. (a) Establishing the correspondence address. (1) If a... correspondence to the practitioner designated in the power. (2) If a practitioner qualified under § 11.14 of...

  15. 37 CFR 2.18 - Correspondence, with whom held.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Correspondence, with whom... Persons § 2.18 Correspondence, with whom held. (a) Establishing the correspondence address. (1) If a... correspondence to the practitioner designated in the power. (2) If a practitioner qualified under § 11.14 of...

  16. 37 CFR 2.18 - Correspondence, with whom held.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Correspondence, with whom... Persons § 2.18 Correspondence, with whom held. (a) Establishing the correspondence address. (1) If a... correspondence to the practitioner designated in the power. (2) If a practitioner qualified under § 11.14 of...

  17. 20 CFR 218.30 - Separation, displacement or dismissal allowance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Separation, displacement or dismissal..., Spouse, or Divorced Spouse Annuity Beginning Date § 218.30 Separation, displacement or dismissal allowance. (a) General. When an employee receives a separation, displacement or dismissal allowance from a...

  18. 33 CFR 157.218 - Dedicated clean ballast tanks: Alterations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Dedicated clean ballast tanks... CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.218 Dedicated clean ballast tanks: Alterations. The dedicated clean ballast tanks or equipment on a tank vessel that has...

  19. 50 CFR 218.125 - Requirements for monitoring and reporting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Activities Area (GoA TMAA) § 218.125 Requirements for monitoring and reporting. (a) General Notification of... under the Letter of Authorization including abiding by the GoA TMAA Monitoring Plan. (http://www.nmfs...; (2) Beginning and end dates of the exercise; and (3) Type of exercise. (f) Annual GoA TMAA Report—The...

  20. 50 CFR 218.125 - Requirements for monitoring and reporting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Activities Area (GoA TMAA) § 218.125 Requirements for monitoring and reporting. (a) General Notification of... under the Letter of Authorization including abiding by the GoA TMAA Monitoring Plan. (http://www.nmfs...; (2) Beginning and end dates of the exercise; and (3) Type of exercise. (f) Annual GoA TMAA Report—The...