Astronaut Hall of Fame Induction Ceremony

NASA Image and Video Library

2017-05-19

In a ceremony set beneath Space Shuttle Atlantis, veteran astronauts C. Michael Foale and Ellen Ochoa are inducted into the U.S. Astronaut Hall of Fame. Foale and Ochoa make up the 16th group of space shuttle astronauts to be inducted into the Hall of Fame, and their addition to the group brings the total number of inductees to 95. More than 20 legendary astronauts were on hand to welcome the inductees, including: Robert Cabana, Dan Brandenstein, Al Worden, Charlie Duke, Charles Bolden, Michael Coats, Robert Crippen, Rhea Seddon, and Fred Gregory.

KSC-04PD-1863

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In the Training Auditorium, astronaut Mike Foale speaks to the audience about his experiences aboard the International Space Station as commander of the Expedition 8 crew. Foale and Flight Engineer Alexander Kaleri spent 194 days, 18 hours and 35 minutes in space, the second longest expedition to be completed aboard the Station. In February Foale and Kaleri conducted the first spacewalk ever performed from the complex by a two-person crew. Foale has accumulated more time in space than any U.S. astronaut, amassing a total of 374 days, 11 hours and 19 minutes in space from his Expedition 8 mission, a 1997 flight to the Russian Mir Space Station, and four Space Shuttle missions.

STS-103 crew looks over Discovery after a night-time landing at the SLF

NASA Technical Reports Server (NTRS)

1999-01-01

After landing at the Shuttle Landing Facility, the STS-103 crew looks over the orbiter Discovery. In the foreground, from left, are Mission Specialist Jean-Francois Clervoy of France, Pilot Scott J. Kelly, Commander Curtis L. Brown Jr. and Mission Specialist C. Michael Foale (Ph.D.); behind them, from left, are Mission Specialists Steven L. Smith and Claude Nicollier of Switzerland. The remaining crew member (not shown) is Mission Specialist John M. Grunsfeld (Ph.D.). The crew of seven completed a successful eight-day mission to service the Hubble Space Telescope, spending the Christmas holiday in space in order to accomplish their mission before the end of 1999. During the mission, Discovery's four space-walking astronauts, Smith, Foale, Grunsfeld and Nicollier, spent 24 hours and 33 minutes upgrading and refurbishing Hubble, making it more capable than ever to renew its observations of the universe. Mission objectives included replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Hubble was released from the end of Discovery's robot arm on Christmas Day. Main gear touchdown was at 7:00:47 p.m. EST. Nose gear touchdown occurred at 7:00:58 EST and wheel stop at 7:01:34 EST. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery. The landing was the 20th consecutive Shuttle landing in Florida and the 13th night landing in Shuttle program history.

STS-103 MS Clervoy and Nicollier and Commander Brown look over Discovery after landing

NASA Technical Reports Server (NTRS)

1999-01-01

After landing at the Shuttle Landing Facility, STS-103 Mission Specialists Jean-Francois Clervoy of France and Claude Nicollier of Switzerland, who are with the European Space Agency, listen to a comment by Commander Curtis L. Brown Jr. while looking over the orbiter Discovery. Other members of the crew are Pilot Scott J. Kelly and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), and John M. Grunsfeld (Ph.D.). The crew of seven completed a successful eight-day mission to service the Hubble Space Telescope, spending the Christmas holiday in space in order to accomplish their mission before the end of 1999. During the mission, Discovery's four space-walking astronauts, Smith, Foale, Grunsfeld and Nicollier, spent 24 hours and 33 minutes upgrading and refurbishing Hubble, making it more capable than ever to renew its observations of the universe. Mission objectives included replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Hubble was released from the end of Discovery's robot arm on Christmas Day. Main gear touchdown was at 7:00:47 p.m. EST. Nose gear touchdown occurred at 7:00:58 EST and wheel stop at 7:01:34 EST. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery. The landing was the 20th consecutive Shuttle landing in Florida and the 13th night landing in Shuttle program history.

KSC-99pp1506

NASA Image and Video Library

1999-12-27

After landing at the Shuttle Landing Facility, the STS-103 crew looks over the orbiter Discovery. In the foreground, from left, are Mission Specialist Jean-Francois Clervoy of France, Pilot Scott J. Kelly, Commander Curtis L. Brown Jr. and Mission Specialist C. Michael Foale (Ph.D.); behind them, from left, are Mission Specialists Steven L. Smith and Claude Nicollier of Switzerland. The remaining crew member (not shown) is Mission Specialist John M. Grunsfeld (Ph.D.). The crew of seven completed a successful eight-day mission to service the Hubble Space Telescope, spending the Christmas holiday in space in order to accomplish their mission before the end of 1999. During the mission, Discovery's four space-walking astronauts, Smith, Foale, Grunsfeld and Nicollier, spent 24 hours and 33 minutes upgrading and refurbishing Hubble, making it more capable than ever to renew its observations of the universe. Mission objectives included replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Hubble was released from the end of Discovery's robot arm on Christmas Day. Main gear touchdown was at 7:00:47 p.m. EST. Nose gear touchdown occurred at 7:00:58 p.m. EST and wheel stop at 7:01:34 p.m. EST. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery. The landing was the 20th consecutive Shuttle landing in Florida and the 13th night landing in Shuttle program history

KSC-99pp1507

NASA Image and Video Library

1999-12-27

After landing at the Shuttle Landing Facility, STS-103 Mission Specialists Jean-Francois Clervoy of France and Claude Nicollier of Switzerland, who are with the European Space Agency, listen to a comment by Commander Curtis L. Brown Jr. while looking over the orbiter Discovery. Other members of the crew are Pilot Scott J. Kelly and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), and John M. Grunsfeld (Ph.D.). The crew of seven completed a successful eight-day mission to service the Hubble Space Telescope, spending the Christmas holiday in space in order to accomplish their mission before the end of 1999. During the mission, Discovery's four space-walking astronauts, Smith, Foale, Grunsfeld and Nicollier, spent 24 hours and 33 minutes upgrading and refurbishing Hubble, making it more capable than ever to renew its observations of the universe. Mission objectives included replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Hubble was released from the end of Discovery's robot arm on Christmas Day. Main gear touchdown was at 7:00:47 p.m. EST. Nose gear touchdown occurred at 7:00:58 p.m. EST and wheel stop at 7:01:34 p.m. EST. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery. The landing was the 20th consecutive Shuttle landing in Florida and the 13th night landing in Shuttle program history

KSC-04PD-1864

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In the Training Auditorium, James Hattaway Jr., KSC associate director, presents a framed graphic to astronaut Mike Foale representing his stay aboard the International Space Station as commander of the Expedition 8 crew. .Foale spoke to the audience of employees about his experiences aboard the Space Station. Foale and Flight Engineer Alexander Kaleri spent 194 days, 18 hours and 35 minutes in space, the second longest expedition to be completed aboard the Station. In February Foale and Kaleri conducted the first spacewalk ever performed from the complex by a two-person crew. Foale has accumulated more time in space than any U.S. astronaut, amassing a total of 374 days, 11 hours and 19 minutes in space from his Expedition 8 mission, a 1997 flight to the Russian Mir Space Station, and four Space Shuttle missions.

STS-45 MS Foale in EMU is lowered into JSC's WETF pool for underwater test

NASA Image and Video Library

1991-02-26

S91-30197 (1 March 1991) --- A wider shot of astronaut C. Michael Foale, mission specialist, standing on a platform which is part of a system that will lower him into a 25-ft. deep pool. Foale used the pool in the weightless environment training facility (WET-F) to rehearse a contingency extravehicular activity (EVA). Two SCUBA-equipped swimmers assist. Astronauts wear pressurized spacesuits configured for achieving a neutrally buoyant condition in the water to simulate both planned and contingency EVAs.

Foale on middeck with tea

NASA Image and Video Library

1997-09-30

S86-E-5346 (30 September 1997) --- This Electronic Still Camera (ESC) image shows astronaut C. Michael Foale, mission specialist, hydrating tea in the middeck of the Earth-orbiting Space Shuttle Atlantis. Foale, now a STS-86 crew member, has been onboard the Russian Mir Space Station as a cosmonaut guest researcher since mid-May 1997. He was replaced by astronaut David A. Wolf during the STS-86 Atlantis/Mir docking mission. This is the seventh Atlantis/Mir docking mission. This view was taken at 00:35:35 GMT on September 30, 1997.

STS-103 crew return at building 990, Ellington Field

NASA Image and Video Library

1999-12-29

Photographic documentation showing STS-103 crew return at bldg. 990, Ellington Field. Views include: Mission Specialist (MS) John M. Grunsfeld at podium (16048); MS Jean-Francois Clervoy at podium (16049); Grunsfeld signs autographs (16050); woman and child (16051); MS Claude Nicollier meets his Swiss-American fan club (16052); Clervoy holds child (16053); mission commander Curtis L. Brown signs autographs (16054, 16057); MS E. Michael Foale signs autographs (16055); MS and Payload Commander (PLC) Steven L. Smith kneels and holds child (16056); overall view of stage showing Brown at podium with crew seated behind him; from left to right: Nicollier, pilot Scott J. Kelly, Clervoy, Grunsfeld, Mr. George Abbey (JSC director), Foale and Smith (16058); Nicollier at podium (16059); Mr. George Abbey at the podium (16060): Foale ath the podium (16061); Kelly signs autographs (16062).

Kuipers holds the Plasma-03 experiment container as Foale looks on during Expedition 9 / Expedition 8

NASA Image and Video Library

2004-04-29

ISS008-E-22393 (29 April 2004) --- European Space Agency (ESA) astronaut Andre Kuipers of the Netherlands, holds a Complex “Plasma-03” canister in the Zvezda Service Module of the International Space Station (ISS). Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, is at right.

KSC-04PD-1862

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In the Training Auditorium, Center Director Jim Kennedy presents a framed photo to astronaut Mike Foale, who spoke to the audience about his experiences aboard the International Space Station as commander of the Expedition 8 crew. Foale and Flight Engineer Alexander Kaleri spent 194 days, 18 hours and 35 minutes in space, the second longest expedition to be completed aboard the Station. In February Foale and Kaleri conducted the first spacewalk ever performed from the complex by a two-person crew. Foale has accumulated more time in space than any U.S. astronaut, amassing a total of 374 days, 11 hours and 19 minutes in space from his Expedition 8 mission, a 1997 flight to the Russian Mir Space Station, and four Space Shuttle missions.

Astronaut Foale is reunited with his family

NASA Technical Reports Server (NTRS)

1997-01-01

Astronaut C. Michael Foale is reunited with his family after an approximate four-and-a-half-month stay aboard the Russian Space Station Mir. Wife Rhonda, 5-year-old Jenna and 3-year-old Ian stayed up for the late-night homecoming after the Oct. 6 landing of the Space Shuttle orbiter Atlantis on the STS-86 mission. Foale, a member of the Mir 24 crew, was dropped off on the Russian space station during the STS-84 mission in mid-May. He joined the STS-86 crew aboard Atlantis for the return trip to Earth. STS-86 was the seventh docking of the Space Shuttle with the Mir. STS-86 Mission Specialist David A. Wolf replaced Foale on the Russian station.

President Bill Clinton visits JSC

NASA Image and Video Library

1998-04-14

S98-05025 (14 April 1998) --- President Bill Clinton tours a laboratory mockup used for training purposes by astronauts assigned to fly aboard the International Space Station (ISS). Astronaut William Shepherd (right), mission commander for the first ISS expedition crew, briefs the Chief Executive. Looking on are astronauts C. Michael Foale and Tamara C. Jernigan. Foale spent four months last year aboard Russia's Mir space station. President Clinton toured several mockups and other training components before speaking to a crowd of JSC employees. Photo Credit: Joe McNally, National Geographic, for NASA

STS-103: Flight Day 6 Highlights and Crew Activities Report

NASA Technical Reports Server (NTRS)

1999-01-01

Discovery's astronauts (Mission Commander, Curtis L. Brown; Pilot, Scott J. Kelly; Mission Specialists, Steven L. Smith, C. Michael Foale, and John M. Grunsfeld; and (ESA) Mission Specialists, Claude Nicollier and Jean-Francois Clervoy) deliver a Christmas present to the world, putting the Hubble Space Telescope back into service after 24 hours and 33 minutes of repairs and upgrades that make the orbital observatory more capable than ever. European Space Agency Astronaut Jean-Francois Clervoy uses the shuttle's robot arm to release the telescope at 5:03 p.m. CST, then places the arm into an upright salute as Commander Curt Brown fires Discovery's steering jets to begin separating from the telescope. The telescope's re-deployment takes place at an altitude of 370 statute miles as the two spacecraft fly over the South Pacific's coral sea northeast of Australia. At 5:39 CST, Brown executes a second steering jet burn, lowering Discovery's orbit slightly, so that it will begin orbiting faster than the telescope and move away at just under 6 statute miles per orbit. Afterward, each of the seven astronauts on board calls down holiday wishes from space in several languages.

Foale and Kuipers work at the MSG during EXP 8 / EXP 9

NASA Image and Video Library

2004-04-22

ISS008-E-21999 (22 April 2004) --- Astronaut C. Michael Foale (foreground), Expedition 8 commander and NASA ISS science officer, and European Space Agency (ESA) astronaut Andre Kuipers of the Netherlands work with the HEAT experiment in the Microgravity Science Glovebox (MSG) in the Destiny laboratory of the International Space Station (ISS). The main aim of the HEAT technology demonstration is the characterization of the heat transfer performance of a grooved heat pipe in weightlessness.

MS Foale performs maintenance on middeck

NASA Image and Video Library

1999-12-21

S103-E-5184 (21 December 1999) --- Astronaut C. Michael Foale, mission specialist, performs a minor maintenance task on the mid deck of the Earth-orbiting Space Shuttle Discovery. The long rectangular structure near Foale's head is the escape pole, which has been standard equipment on the shuttle fleet since 1988. The photo was recorded with an electronic still camera (ESC) at 10:39:31 GMT, Dec. 21, 1999.

Foale in Base Block with camera

NASA Image and Video Library

1997-11-03

STS086-405-008 (25 Sept-6 Oct 1997) --- Astronaut C. Michael Foale, sporting attire representing the STS-86 crew after four months aboard Russia?s Mir Space Station in Russian wear, operates a video camera in Mir?s Base Block Module. Photo credit: NASA

Foale performs IFM at the science window in the U.S. Lab during Expedition 8

NASA Image and Video Library

2004-04-23

ISS008-E-22271 (23 April 2004) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, performs in-flight maintenance (IFM) on the nadir window in the Destiny laboratory of the International Space Station (ISS).

Foale and Kuipers conduct ARGES experiment OPS at the MSG during EXP 8 / EXP 9

NASA Image and Video Library

2004-04-24

ISS008-E-22127 (24 April 2004) --- Astronaut C. Michael Foale (left), Expedition 8 commander and NASA ISS science officer, and European Space Agency (ESA) astronaut Andre Kuipers of the Netherlands work with the ARGES experiment for the Microgravity Science Glovebox (MSG) in the Destiny laboratory of the International Space Station (ISS). The main objectives of ARGES are to determine which factors are critical in the onset of instabilities in High-Intensity Discharge (HID) lamps and to characterize the separation of individual gaseous elements inside.

Foale holds the top endcap for the TVIS Gyroscope in SM during Expedition 8

NASA Image and Video Library

2003-12-09

ISS008-E-07384 (9 Dec. 2003) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, holds the top end-cap for the Treadmill Vibration Isolation System (TVIS) gyroscope in the Zvezda Service Module on the International Space Station (ISS).

Foale works at the MSG / ESEM in the U.S. Lab during Expedition 8

NASA Image and Video Library

2004-04-05

ISS008-E-20622 (5 April 2004) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, conducts an inspection of the Microgravity Science Glovebox (MSG) / Exchangeable Standard Electronic Module (ESEM) in the Destiny laboratory of the International Space Station (ISS).

Foale works at the MSG / ESEM in the U.S. Lab during Expedition 8

NASA Image and Video Library

2004-04-05

ISS008-E-20632 (5 April 2004) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, conducts an inspection of the Microgravity Science Glovebox (MSG) / Exchangeable Standard Electronic Module (ESEM) in the Destiny laboratory of the International Space Station (ISS).

Foale performs FOOT experiment OPS in the U.S. Lab during Expedition 8

NASA Image and Video Library

2003-12-03

ISS008-E-06862 (3 December 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, attired in instrumented biking tights, participates in the Foot/Ground Reaction Forces During Spaceflight (FOOT) experiment in the Destiny laboratory on the International Space Station (ISS). The Lower Extremity Monitoring Suit (LEMS), the cycling tights outfitted with 20 sensors, measured forces on Foale’s feet and joints and muscle activity while he went about his scheduled activities.

Foale performs FOOT experiment OPS in the U.S. Lab during Expedition 8

NASA Image and Video Library

2004-04-07

ISS008-E-20901 (7 April 2004) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, balances on the footplate of a special track attached to the Human Research Facility (HRF) rack in the Destiny laboratory on the International Space Station (ISS) to perform Foot/Ground Reaction Forces During Spaceflight (FOOT) / Electromyography (EMG) calibration operations. Foale is wearing the Lower Extremity Monitoring Suit (LEMS), the cycling tights outfitted with 20 sensors, which measures forces on joints and muscle activity.

2nd EVA - MS Foale and Nicollier during FGS changeout

NASA Image and Video Library

1999-12-24

STS103-501-026 (19 - 27 December 1999) --- Astronauts C. Michael Foale, left, and Claude Nicollier (on Discovery's robotic arm) install a Fine Guidance Sensor (FGS) into a protective enclosure in the Shuttle’s payload bay. Foale and Nicollier performed the second of three space walks to service the Hubble Space Telescope (HST) on the STS-103 mission. A large format camera inside Discovery's cabin was used to record this high-resolution image, while the Shuttle was orbiting above ocean and clouds.

KSC-97PC1506

NASA Image and Video Library

1997-10-06

Astronaut C. Michael Foale gets extra-special care back on Earth from his family and his flight physician after an approximate four-and-a-half-month stay aboard the Russian Space Station Mir. Dr. Terry Tadeo, a NASA physician who has been monitoring the astronaut’s health during his stay on the Mir, pushes the wheelchair holding Foale and the space flyer’s two children, 3-year-old Ian and 5-year-old Jenna, through the astronaut crew quarters of the Operations and Checkout Building. Foale’s wife, Rhonda, is in background at left. Foale’s family was at KSC for the late-night reunion after the Oct. 6 landing of the Space Shuttle orbiter Atlantis on the STS-86 mission. Foale, a member of the Mir 24 crew, was dropped off on the Russian space station during the STS-84 mission in mid-May. He joined the STS-86 crew aboard Atlantis for the return trip to Earth. STS-86 was the seventh docking of the Space Shuttle with the Mir. STS-86 Mission Specialist David A. Wolf replaced Foale on the Russian station

Crewmember activity in the shuttle middeck and flight deck

NASA Image and Video Library

1997-06-20

STS084-356-017 (15-24 May 1997) --- Prior to the Space Shuttle Atlantis' docking with Russia's Mir Space Station, astronaut C. Michael Foale was photographed on the middeck going over checklists. Before the mission was complete, Foale had traded in his current attire for that of his scheduled environs for the next several months onboard Mir.

Foale poses beside the LADA-4 greenhouse in the U.S. Lab during Expedition 8

NASA Image and Video Library

2004-04-12

ISS008-E-21908 (12 April 2004)--- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, poses beside the pea plants growing in the Lada-4 greenhouse as part of the BIO-5 Rasteniya-2 (Plants-2) experiment located in the Zvezda Service Module of the International Space Station.

2017 Astronaut Hall of Fame Induction Ceremony

NASA Image and Video Library

2017-05-19

In the Space Shuttle Atlantis facility at the Kennedy Space Center Visitor Complex in Florida, Astronaut Scholarship Foundation Chairman Dan Brandenstein, left, also a Hall of Fame astronaut, presents inductee Ellen Ochoa with her hall of fame medal. Former Johnson Space Center Director Mike Coats, right, a Hall of Fame member, presented Ochoa for induction. During this year's ceremonies, space shuttle astronaut Michael Foale also was enshrined.

KSC-97PC791

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist C. Michael Foale laughs during a rare moment of relaxation just a few hours before the scheduled launch. Foale is donning his launch and entry suit in the Operations and Checkout Building. This will be Foale’s fourth space flight. Foale and six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff on a mission to dock with the Russian Space Station Mir. Foale will transfer to Mir for an approximate fourmonth stay, replacing U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger will return to Earth on Atlantis

STS-45 MS Foale in EMU prepares for underwater exercises in JSC's WETF pool

NASA Image and Video Library

1991-02-26

S91-30196 (1 March 1991) --- Astronaut C. Michael Foale, mission specialist, and Kathryn D. Sullivan, payload commander (barely visible in background), stand on a platform (out of frame) which is part of a system that will lower them into a 25-ft. deep pool. The payload commander and mission specialist used the pool in the weightless environment training facility (WET-F) to rehearse a contingency extravehicular activity (EVA). Astronauts wear pressurized spacesuits configured for achieving a neutrally buoyant condition in the water to simulate both planned and contingency EVAs. Two SCUBA-equipped swimmers assisting the training are seen in the background.

Expedition 8 Returns Home

NASA Image and Video Library

2004-04-30

JSC2004-E-21242 (30 April 2004) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, gives thumbs up after he and his crewmates, cosmonaut Alexander Y. Kaleri, Soyuz flight engineer representing Russia?s Federal Space Agency, and European Space Agency (ESA) astronaut Andre Kuipers of the Netherlands, successfully landed in north central Kazakhstan on April 30, 2004, in their Soyuz TMA-3 capsule. Foale and Kaleri completed 195 days in space aboard the International Space Station (ISS), while Kuipers returned after an 11-day research mission as part of a commercial agreement between ESA and Russia?s Federal Space Agency. Photo credit: NASA/Bill Ingalls

KSC-97pc720

NASA Image and Video Library

1997-04-28

STS-84 Mission Specialist C. Michael Foale, who will become the fifth U.S. astronaut to live and work on the Russian Space Station Mir, arrives at KSC’s Shuttle Landing Facility for the STS-84 Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. Foale will be dropped off on Mir when the Space Shuttle Atlantis docks with Mir next month. He will become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth on Atlantis after about four months on the orbiting station. STS-84 will be the sixth Shuttle-Mir docking. Liftoff is targeted for May 15

Expedition 8 Launch Briefing

NASA Image and Video Library

2003-10-12

Expedition 8 Commander and NASA Science Officer Michael Foale talks to a colleague on his cell phone from his crew quarters at the Cosmonaut Hotel in Baikonur, Kazakhstan, Wednesday, Oct. 15, 2003. Foale along with Expedition 8 Soyuz Commander Alexander Kaleri and European Space Agency astronaut Pedro Duuque of Spain, launched on a Soyuz TMA-3 vehicle to the International Space Station. Photo Credit (NASA/Bill Ingalls)

Foale performs potable water analysis OPS in the SM during Expedition 8

NASA Image and Video Library

2003-11-07

ISS008-E-05553 (7 November 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, floats in front of the galley in the Zvezda Service Module on the International Space Station (ISS) as he fills a Crew Healthcare System (CheCSS) Water Microbiology (WMK) in-flight analysis bag from the potable warter dispenser.

STS-56 MS1 Foale, in LES/LEH, floats during bailout exercises in JSC WETF

NASA Technical Reports Server (NTRS)

1993-01-01

STS-56 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist 1 (MS1) Michael Foale, wearing launch and entry suit (LES) and launch and entry helmet (LEH), floats in a single person life raft during launch emergency egress (bailout) exercises in JSC's Weightless Environment Training Facility (WETF) Bldg 29 pool. Foale's body is covered with the life raft tarp. His head and the space shuttle search and rescue satellite aided tracking (SARSAT) antenna protrude above the tarp. This simulation prepares the astronauts for the event of an emergency egress and subsequent water landing during launch.

03pd2805

NASA Image and Video Library

2003-10-13

October 13, 2003. Baikonur Cosmodrome, Kazakhstan. Expedition 8 Soyuz Commander Alexander Kaleri (left) and Expedition 8 Commander and NASA Science Officer Mike Foale visit the launch pad at the Baikonur Cosmodrome in Kazakhstan Oct. 13, 2003. Foale, Kaleri and European Space Agency Astronaut Pedro Duque of Spain will be launched from the Central Asian launch pad to the International Space Station on Oct. 18. Photo Credit"NASA/Bill Ingalls"

Foale during telecon in the U.S. Lab during Expedition 8

NASA Image and Video Library

2003-12-28

ISS008-E-10745 (28 December 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, conducts a teleconference with the Moscow Support Group for the Russian New Year celebration, via Ku- and S-band, with audio and video relayed to the Mission Control Center (MCC) at Johnson Space Center (JSC). Holiday decorations are visible in the background.

Foale uses takes photographs of a BCAT SGSM in the U.S. Lab during Expedition 8

NASA Image and Video Library

2004-04-05

ISS008-E-20613 (5 April 2004) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, works with a Slow Growth Sample Module (SGSM) for the Binary Colloidal Alloy Test-3 (BCAT) experiment. The SGSM is on a mounting bracket attached to the Maintenance Work Area (MWA) table set up in the Destiny laboratory of the International Space Station (ISS).

Kaleri and Foale during telecon in the U.S. Lab during Expedition 8

NASA Image and Video Library

2003-12-28

ISS008-E-10698 (28 December 2003) --- Cosmonaut Alexander Y. Kaleri (foreground), Expedition 8 flight engineer, and astronaut C. Michael Foale, mission commander and NASA ISS science officer, conduct a teleconference with the Moscow Support Group for the Russian New Year celebration, via Ku- and S-band, with audio and video relayed to the Mission Control Center (MCC) at Johnson Space Center (JSC). Kaleri represents Rosaviakosmos.

Kaleri and Foale during telecon in the U.S. Lab during Expedition 8

NASA Image and Video Library

2003-12-28

ISS008-E-10737 (28 Dec. 2003) --- Astronaut C. Michael Foale (right), Expedition 8 mission commander and NASA ISS science officer, and cosmonaut Alexander Y. Kaleri, flight engineer, conduct a teleconference with the Moscow Support Group for the Russian New Year celebration, via Ku- and S-band, with audio and video relayed to the Mission Control Center (MCC) at Johnson Space Center (JSC). Kaleri represents Rosaviakosmos.

Kaleri and Foale during telecon in the U.S. Lab during Expedition 8

NASA Image and Video Library

2003-12-28

ISS008-E-10711 (28 December 2003) --- Cosmonaut Alexander Y. Kaleri (foreground), Expedition 8 flight engineer, and astronaut C. Michael Foale, mission commander and NASA ISS science officer, conduct a teleconference with the Moscow Support Group for the Russian New Year celebration, via Ku- and S-band, with audio and video relayed to the Mission Control Center (MCC) at Johnson Space Center (JSC). Kaleri represents Rosaviakosmos.

Foale and Kaleri pose beside the LADA-4 greenhouse in the U.S. Lab during Expedition 8

NASA Image and Video Library

2004-04-12

ISS008-E-21916 (12 April 2004)--- Astronaut C. Michael Foale (left), Expedition 8 commander and NASA ISS science officer; and Alexander Kaleri, Russia's Federal Space Agency flight engineer, pose beside the pea plants growing in the Lada-4 greenhouse as part of the BIO-5 Rasteniya-2 (Plants-2) experiment located in the Zvezda Service Module of the International Space Station.

Expedition 8 Returns Home

NASA Image and Video Library

2004-04-30

JSC2004-E-21252 (30 April 2004) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, is carried in a chair from the Soyuz landing site to an inflatable medical tent after he and his crewmates, cosmonaut Alexander Y. Kaleri (out of frame), Soyuz flight engineer representing Russia’s Federal Space Agency, and European Space Agency (ESA) astronaut Andre Kuipers (out of frame) of the Netherlands, successfully landed in north central Kazakhstan on April 30, 2004, in their Soyuz TMA-3 capsule. Foale and Kaleri completed 195 days in space aboard the International Space Station (ISS), while Kuipers returned after an 11-day research mission as part of a commercial agreement between ESA and Russia’s Federal Space Agency. Photo Credit: NASA/Bill Ingalls

Astronaut Bernard Harris monitors Spacehab experiments

NASA Image and Video Library

1995-02-03

STS063-68-013 (3-11 Feb 1995) --- Astronaut Bernard A. Harris, Jr., a physician and payload commander, monitors several Spacehab-3 experiments which occupy locker space on the Space Shuttle Discovery's mid-deck. The Spacehab 3 Module is located in the cargo bay. Others onboard the Discovery were astronauts James D. Wetherbee, commander; Eileen M. Collins, pilot; mission specialists C. Michael Foale, Janice E. Voss, and Russian cosmonaut Vladimir G. Titov.

Foale works with the Pilot experiment during Expedition 8

NASA Image and Video Library

2003-10-31

ISS008-E-05181 (31 October 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, works with the Russian biomedical “Pilot” experiment (MBI-15) in the Zvezda Service Module on the International Space Station (ISS). The experiment, which looks at psychological and physiological changes in crew performance during long-duration spaceflight, requires a worktable, ankle restraint system and two control handles for testing piloting skill.

Foale conducts MSG setup for PFMI experiment in U.S. Lab during Expedition 8

NASA Image and Video Library

2003-11-28

ISS008-E-06301 (28 November 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, installs equipment in the Microgravity Science Glovebox (MSG) for the Pore Formation and Mobility Investigation (PFMI) experiment in the Destiny laboratory on the International Space Station (ISS). This experiment studies how bubbles form in metal and crystal samples, thus deteriorating the samples’ strength and usefulness in experiments.

Foale conducts MSG setup for PFMI experiment in U.S. Lab during Expedition 8

NASA Image and Video Library

2003-11-28

ISS008-E-06309 (28 November 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, installs equipment in the Microgravity Science Glovebox (MSG) for the Pore Formation and Mobility Investigation (PFMI) experiment in the Destiny laboratory on the International Space Station (ISS). This experiment studies how bubbles form in metal and crystal samples, thus deteriorating the samples’ strength and usefulness in experiments.

Foale conducts MSG setup for PFMI experiment in U.S. Lab during Expedition 8

NASA Image and Video Library

2003-11-28

ISS008-E-06300 (28 November 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, installs equipment in the Microgravity Science Glovebox (MSG) for the Pore Formation and Mobility Investigation (PFMI) experiment in the Destiny laboratory on the International Space Station (ISS). This experiment studies how bubbles form in metal and crystal samples, thus deteriorating the samples’ strength and usefulness in experiments.

STS-103 Crew Training

NASA Technical Reports Server (NTRS)

1999-01-01

The Hubble Space Telescope (HST) team is preparing for NASA's third scheduled service call to Hubble. This mission, STS-103, will launch from Kennedy Space Center aboard the Space Shuttle Discovery. The seven flight crew members are Commander Curtis L. Brown, Pilot Scott J. Kelly, European Space Agency (ESA) astronaut Jean-Francois Clervoy who will join space walkers Steven L. Smith, C. Michael Foale, John M. Grunsfeld, and ESA astronaut Claude Nicollier. The objectives of the HST Third Servicing Mission (SM3A) are to replace the telescope's six gyroscopes, a Fine-Guidance Sensor, an S-Band Single Access Transmitter, a spare solid-state recorder and a high-voltage/temperature kit for protecting the batteries from overheating. In addition, the crew plans to install an advanced computer that is 20 times faster and has six times the memory of the current Hubble Space Telescope computer. To prepare for these extravehicular activities (EVAs), the SM3A astronauts participated in Crew Familiarization sessions with the actual SM3A flight hardware. During these sessions the crew spent long hours rehearsing their space walks in the Guidance Navigation Simulator and NBL (Neutral Buoyancy Laboratory). Using space gloves, flight Space Support Equipment (SSE), and Crew Aids and Tools (CATs), the astronauts trained with and verified flight orbital replacement unit (ORU) hardware. The crew worked with a number of trainers and simulators, such as the High Fidelity Mechanical Simulator, Guidance Navigation Simulator, System Engineering Simulator, the Aft Shroud Door Trainer, the Forward Shell/Light Shield Simulator, and the Support Systems Module Bay Doors Simulator. They also trained and verified the flight Orbital Replacement Unit Carrier (ORUC) and its ancillary hardware. Discovery's planned 10-day flight is scheduled to end with a night landing at Kennedy.

Foale uses takes photographs of a BCAT SGSM in the U.S. Lab during Expedition 8

NASA Image and Video Library

2004-04-05

ISS008-E-20610 (5 April 2004) --- Astronaut C. Michael Foale, Expedition 8 commander and NASA ISS science officer, uses a digital still camera to photograph a Slow Growth Sample Module (SGSM) for the Binary Colloidal Alloy Test-3 (BCAT) experiment. The SGSM is on a mounting bracket attached to the Maintenance Work Area (MWA) table set up in the Destiny laboratory of the International Space Station (ISS).

03pd2813

NASA Image and Video Library

2003-10-15

October 15, 2003. Cosmonaut Hotel, Baikonur, Kazakhstan. Expedition 8 Commander and NASA Science Officer Mike Foale talks to a colleague on his cell phone from his Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan Oct. 15, 2003 as he continues prelaunch preparations for his launch on Oct. 18 on a Soyuz TMA-3 vehicle to the International Space Station. Foale will ride into orbit with Expedition 8 Soyuz Commander Alexander Kaleri and European Space Agency Astronaut Pedro Duuque of Spain. Photo Credit: "NASA/Bill Ingalls"

KSC-97PC1510

NASA Image and Video Library

1997-10-07

Still celebrating his recent homecoming and reunion with his family, astronaut C. Michael Foale picks up his 3-year-son Ian, while his 5-year-old daughter, Jenna, stands by at the Skid Strip on Cape Canaveral Air Station. They are scheduled to depart shortly for the astronauts’ home base at Johnson Space Center in Houston, Texas. Foale spent approximately four-and-a-half months on the Russian Space Station Mir. He returned to Earth on Oct. 6 aboard the Space Shuttle orbiter Atlantis at the conclusion of the STS-86 mission. STS-86 was the seventh docking of the Space Shuttle with the Mir. Foale was replaced on the Mir by STS-86 Mission Specialist David A. Wolf

KSC-97PC1507

NASA Image and Video Library

1997-10-06

Astronaut C. Michael Foale is reunited with his family after an approximate four-and-a-half-month stay aboard the Russian Space Station Mir. Wife Rhonda, 5-year-old Jenna and 3-year-old Ian stayed up for the late-night homecoming after the Oct. 6 landing of the Space Shuttle orbiter Atlantis on the STS-86 mission. Foale, a member of the Mir 24 crew, was dropped off on the Russian space station during the STS-84 mission in mid-May. He joined the STS-86 crew aboard Atlantis for the return trip to Earth. STS-86 was the seventh docking of the Space Shuttle with the Mir. STS-86 Mission Specialist David A. Wolf replaced Foale on the Russian station

STS-103 crewmembers during NBL EVA training

NASA Image and Video Library

1999-06-21

S99-06194 (21 June 1999) --- Astronaut C. Michael Foale, mission specialist, rehearses Extravehicular Activity (EVA) with the Hubble Space Telescope (HST) mockup in the Neutral Buoyancy Laboratory (NBL).

EVA 1 activity on Flight Day 4 to service the Hubble Space Telescope

NASA Image and Video Library

1997-02-14

STS082-730-090 (11-21 Feb. 1997) --- Astronaut Steven L. Smith handles one of the Goddard High Resolution Spectrograph (GHRS) boxes, changed out on the Hubble Space Telescope (HST) on Flight Day 4. Astronauts Smith and Mark C. Lee were participating in the first of five eventual days of Extravehicular Activity (EVA) to service the giant orbital observatory. Smith is standing on the end of the Remote Manipulator System (RMS) arm, which was controlled by astronaut Steven A. Hawley inside the Space Shuttle Discovery's crew cabin.

STS-56 MS1 Foale uses SAREX on forward flight deck of Discovery, OV-103

NASA Image and Video Library

1993-04-17

STS056-30-001 (8-17 April 1993) --- Aboard Discovery, astronaut C. Michael Foale, (call letters KB5UAC), talks to amateur radio operators on Earth via the Shuttle Amateur Radio Experiment (SAREX). SAREX was established by NASA, the American Radio League/Amateur Radio Satellite Corporation and the Johnson Space Center Amateur Radio Club to encourage public participation in the space program through an endeavor to demonstrate the effectiveness of conducting short-wave radio transmissions. These transmissions occur between the Shuttle and ground-based radio operators at low cost ground stations with amateur and digital techniques. As on several previous missions, SAREX was used on this flight as an educational opportunity for students around the world to learn about space firsthand by speaking directly to astronauts aboard the Shuttle.

Astronaut Harris checks response of muscles to microgravity

NASA Image and Video Library

1995-02-03

STS063-86-016 (3-11 Feb 1995) --- With astronaut Janice E. Voss, mission specialist, as his test subject, astronaut Bernard A. Harris, Jr., payload commander and a physician, uses a special biomedical harness experiment to check the response of muscles to microgravity. They are on the mid-deck, where many of the SpaceHab 3 experiments are located. The SpaceHab 3 Module is in the cargo bay. Others onboard the Space Shuttle Discovery were astronauts James D. Wetherbee, commander; Eileen M. Collins, pilot; mission specialists C. Michael Foale and Russian cosmonaut Vladimir G. Titov.

NASA Space Day in Mississippi - House of Representatives

NASA Technical Reports Server (NTRS)

2008-01-01

Astronaut Michael Foale (center) and Stennis Space Center officials met with Mississippi House of Representatives Gulf Coast delegation, including Speaker William 'Billy' McCoy (far right), during NASA Space Day in Mississippi on January 30.

KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush at NASA Headquarters in Washington, D.C., stating his goals for NASA’s new mission: Completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

NASA Image and Video Library

2004-01-14

KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush at NASA Headquarters in Washington, D.C., stating his goals for NASA’s new mission: Completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

NASA Space Day in Mississippi - Senate

NASA Image and Video Library

2008-01-30

Astronaut Michael Foale (center) and Stennis Space Center officials met with Mississippi Lt. Gov. Phil Bryant (at rear podium) and Gulf Coast delegation members in Mississippi Senate chambers during NASA Space Day in Mississippi activities at the Capitol on January 30.

NASA Space Day in Mississippi - Senate

NASA Technical Reports Server (NTRS)

2008-01-01

Astronaut Michael Foale (center) and Stennis Space Center officials met with Mississippi Lt. Gov. Phil Bryant (at rear podium) and Gulf Coast delegation members in Mississippi Senate chambers during NASA Space Day in Mississippi activities at the Capitol on January 30.

Astronaut Pedro Duque Watches A Water Bubble

NASA Technical Reports Server (NTRS)

2003-01-01

Aboard the International Space Station (ISS), European Space Agency astronaut Pedro Duque of Spain watches a water bubble float between a camera and himself. The bubble shows his reflection (reversed). Duque was launched aboard a Russian Soyuz TMA-3 spacecraft from the Baikonur Cosmodrome, Kazakhstan on October 18th, along with expedition-8 crew members Michael C. Foale, Mission Commander and NASA ISS Science Officer, and Cosmonaut Alexander Y. Kaleri, Soyuz Commander and flight engineer.

STS-103 Mission Highlights Resource Tape (1 of 2)

NASA Technical Reports Server (NTRS)

2000-01-01

The STS-103 flight crew, Commander Curtis L. Brown, Pilot Scott J. Kelly, Mission Specialists Steven L. Smith, C. Michael Foale, John M. Grunsfeld, Claude Nicollier, and Jean-Francois Clervoy, are seen performing pre-launch activities such as crew suit-up, and ride out to the launch pad for a night launch. Also, included are various panoramic views of the shuttle on the pad. The crew is readied in the White Room for their mission. After the closing of the hatch and arm retraction, launch activities are shown including countdown, engine ignition, launch, and the separation of the Solid Rocket Boosters. Once on-orbit the primary objective is to capture and service the Hubble Space Telescope. Included are various live shots of the payload bay showing the flight support system, the orbiter replacement unit carrier and the forward fixture that house the new Fine Guidance System (FGS). Smith and Grunsfeld replaces and changes the sensor units during the first space walk of this mission. The second space walk by Nicollier and Foale includes the changing of the computer and installation of the FGS. This is tape 1 of 2, tape 2 has a report number of NONP-NASA-VT-2000036031.

Two ESA astronauts named to early Hubble Space Telescope servicing mission

NASA Astrophysics Data System (ADS)

1999-03-01

Nicollier and three NASA astronauts, who had already been training for a Hubble servicing mission planned for June 2000, have been reassigned to this earlier mission (STS-103). Jean-Francois Clervoy and two other NASA astronauts will complete the STS-103 crew. The repairs and maintenance of the telescope will require many hours spent working outside the Shuttle and will make extensive use of the Shuttle's robotic arm Nicollier, of Swiss nationality and making his fourth flight, will be part of the team that will perform the "spacewalks". An astronomer by education, he took part in the first Hubble servicing mission (STS-61) in 1993, controlling the Shuttle's robotic arm while astronauts on the other end of the arm performed the delicate repairs to the telescope. He also served on STS-46 in 1992 using the robotic arm to deploy ESA's Eureca retrievable spacecraft from the Shuttle, and on STS-75 with the Italian Tethered Satellite System in 1996. Nicollier is currently the chief of the robotics branch in NASA's astronaut office and ESA's lead astronaut in Houston. Jean-Francois Clervoy, of French nationality and making his third flight, will have the lead role in the operation of the robotic arm for this mission. He previously served on STS-66 in 1994 using the robotic arm to deploy and later retrieve the German CRISTA-SPAS atmospheric research satellite, and on STS-84 in 1997, a Shuttle mission to the Russian Mir space station. The other STS-103 crewmembers are: Commander Curtis Brown, pilot Scott Kelly, and mission specialists Steven Smith, Michael Foale and John Grunsfeld. During the flight, the astronauts will replace Hubble's failing pointing system, which allows the telescope to aim at stars, planets and other targets, and install other equipment that will be ready for launch at that time. A second mission to complete the previously-scheduled Hubble refurbishment work is foreseen at a later date. The crew for that mission has not yet been assigned. The Hubble Space Telescope, launched in 1990, is one of the most powerful optical telescopes available to astronomers today, producing images and spectral observations at the forefront of astronomy. ESA contributed a 15 share to the development of Hubble and European astronomers receive in return a guaranteed 15 share of observing time (and 20 on average in practice).

STS-84 Crew speaking at TCDT Press Briefing

NASA Technical Reports Server (NTRS)

1997-01-01

STS-84 crew members listen intently to Commander Charles J. Precourt, at far right, as he talks to news media representatives and other onlookers at Launch Pad 39A during the Terminal Countdown Demonstration Test (TCDT). Other crew members, from left, are Mission Specialist Edward Tsang Lu, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Jean-Francois Clervoy of the European Space Agency, C. Michael Foale, and Elena V. Kondakova of the Russian Space Agency. STS-84 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. After docking, Foale will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. STS-84 is targeted for a May 15 liftoff.

Returning Mir 23 crewmember, U.S. astronaut Jerry Linenger, with family following landing of STS-84

NASA Technical Reports Server (NTRS)

1997-01-01

Astronaut and recent Mir 23 crew member Jerry M. Linenger, standing, reunites with his wife, Kathryn, and their 18-month-old son, John, in the astronaut suit-up room in the Operations and Checkout Building. Kathryn Linenger is expecting their second child next month. Linenger just returned to Earth after a four- month stay on the Russian Space Station Mir. He flew back on Atlantis with six other members of the STS-84 crew, who conducted the sixth Space Shuttle docking with the Mir. STS-84 Mission Specialist C. Michael Foale replaced Linenger on the Mir.

STS-103 Mission Specialist Smith suits up before launch

NASA Technical Reports Server (NTRS)

1999-01-01

After donning his launch and entry suit, sts-103 Mission Specialist Steven L. Smith shows a positive attitude over the second launch attempt for Space Shuttle Discovery. The previous launch attempt on Dec. 17 was scrubbed about 8:52 p.m. due to numerous violations of weather launch commit criteria at KSC. Smith and other crew members Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-Francois Clervoy of France are scheduled to lift off at 7:50 p.m. EST Dec. 19 on mission STS-103, servicing the Hubble Space Telescope. Objectives for the nearly eight-day mission include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Discovery is expected to land at KSC Monday, Dec. 27, at about 5:24 p.m. EST.

Space Shuttle Projects

NASA Image and Video Library

1999-07-01

The STS-103 crew portrait includes (from left) C. Michael Foale, mission specialist; Claude Nicollier, mission specialist representing the European Space Agency (ESA) ; Scott J. Kelly, pilot; Curtis L. Brown, commander; and mission specialists Jean-Francois Clervoy (ESA), John M. Grunsfeld, and Steven L. Smith. Launched aboard the Space Shuttle Discovery on December 19, 1999 at 6:50 p.m. (CST), the STS-103 mission served as the third Hubble Space Telescope (HST) servicing mission.

KSC-97pc783

NASA Image and Video Library

1997-05-11

STS-84 crew members greet press representatives and other onlookers after their arrival at KSC’s Shuttle Landing Facility Sunday evening (May 12, 1997), about an hour before the countdown clock will begin ticking toward the scheduled May 15 launch of the Space Shuttle Atlantis on Mission STS-84. From left, are Mission Specialist Carlos I. Noriega, Pilot Eileen Marie Collins, Mission Specialist C. Michael Foale, Mission Specialist Elena V. Kondakova of the Russian Space Agency, Commander Charles J. Precourt, Mission Specialist Jean-Francois Clervoy of the European Space Agency, and Mission Specialist Edward Tsang Lu. STS-84 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Foale will transfer to the Russian space station to become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth on Atlantis. Foale is scheduled to remain on Mir about four months until his replacement arrives on STS-86 in September

KSC-97PC856

NASA Image and Video Library

1997-05-24

Astronaut and recent Mir 23 crew member Jerry M. Linenger, standing, reunites with his wife, Kathryn, and their 18-month-old son, John, in the astronaut suit-up room in the Operations and Checkout Building. Kathryn Linenger is expecting their second child next month. Linenger just returned to Earth after a four-month stay on the Russian Space Station Mir. He flew back on Atlantis with six other members of the STS-84 crew, who conducted the sixth Space Shuttle docking with the Mir. STS-84 Mission Specialist C. Michael Foale replaced Linenger on the Mir

STS-84 Commander Charlie Precourt at TCDT Press Meeting

NASA Technical Reports Server (NTRS)

1997-01-01

STS-84 Commander Charles J. Precourt talks to news media representatives and other onlookers during Terminal Countdown Demonstration Test (TCDT) activities at Launch Pad 39A. Two-time space flyer Precourt will lead the other six STS-84 crew members on the sixth docking of the Space Shuttle with the Russian Space Station Mir. One of the crew members, C. Michael Foale, will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. STS-84 is targeted for a May 15 liftoff.

Malenchenko and Lu in Pirs Docking Compartment (DC-1) module

NASA Image and Video Library

2003-10-20

ISS007-E-17761 (20 October 2003) --- The Expedition 7 crewmembers, cosmonaut Yuri I. Malenchenko, mission commander representing Rosaviakosmos; and astronaut Edward T. Lu, NASA ISS science officer and flight engineer, pose for a photo by a camera triggered for a change by something other than auto-set or remote means. The photographer in this case was one of the newly arrived Expedition 8 crewmembers, astronaut C. Michael Foale, American commander and NASA ISS science officer and cosmonaut Alexander Kaleri, Russian flight engineer and Soyuz commander; or possibly European Space Agency astronaut Pedro Duque, who joined the Expedition 8 crew for the trip "up" and who will return to Earth on Oct. 28 with the Expedition 7 crew.

Soyuz TMA-3 and booster rocket transport and raise on launch pad at Baikonur Cosmodrome

NASA Image and Video Library

2003-10-15

JSC2003-E-59146 (16 October 2003) --- The Soyuz TMA-3 spacecraft and its booster rocket were transported on a rail car to its launch pad and raised to its vertical launch position at the Baikonur Cosmodrome, Kazakhstan on October 16, 2003, in preparation for liftoff October 18 to carry astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer; cosmonaut Alexander Kaleri, Soyuz commander and flight engineer, representing Rosaviakosmos; and European Space Agency (ESA) astronaut Pedro Duque of Spain to the International Space Station (ISS). Photo Credit: "NASA/Bill Ingalls"

Soyuz TMA-3 and booster rocket transport and raise on launch pad at Baikonur Cosmodrome

NASA Image and Video Library

2003-10-15

JSC2003-E-59150 (16 October 2003) --- The Soyuz TMA-3 spacecraft and its booster rocket were transported on a rail car to its launch pad and raised to its vertical launch position at the Baikonur Cosmodrome, Kazakhstan on October 16, 2003, in preparation for liftoff October 18 to carry astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer; cosmonaut Alexander Kaleri, Soyuz commander and flight engineer, representing Rosaviakosmos; and European Space Agency (ESA) astronaut Pedro Duque of Spain to the International Space Station (ISS). Photo Credit: "NASA/Bill Ingalls"

Soyuz TMA-3 and booster rocket transport and raise on launch pad at Baikonur Cosmodrome

NASA Image and Video Library

2003-10-15

JSC2003-E-59158 (16 October 2003) --- The Soyuz TMA-3 spacecraft and its booster rocket were transported on a rail car to its launch pad and raised to its vertical launch position at the Baikonur Cosmodrome, Kazakhstan on October 16, 2003, in preparation for liftoff October 18 to carry astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer; cosmonaut Alexander Kaleri, Soyuz commander and flight engineer, representing Rosaviakosmos; and European Space Agency (ESA) astronaut Pedro Duque of Spain to the International Space Station (ISS). Photo Credit: "NASA/Bill Ingalls"

STS-86 Mission Specialist Wolf arrives at SLF before launch

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf, the next U.S. astronaut slated to live and work on the Russian Space Station Mir, is all smiles after his arrival at KSCs Shuttle Landing Facility on Monday. Wolf is making his second spaceflight on STS-86, scheduled to be the seventh docking of the Shuttle with the Mir. After the docking, Wolf will transfer to the Mir for an approximate four-month stay. He replaces U.S. astronaut C. Michael Foale, who arrived at Mir in May and will return to Earth with the remainder of the STS-86 crew.

KSC-97pc755

NASA Image and Video Library

1997-04-29

STS-84 crew members ride in and learn how to operate an M-113 armored personnel carrier as part of the Terminal Countdown Demonstration Test (TCDT) activities. In the front seat is Pilot Eileen Marie Collins. George Hoggard, a training officer with KSC Fire Services, sits beside her on top of the personnel carrier. Directly behind Hoggard, from left, are Commander Charles J. Precourt and Mission Specialist Elena V. Kondakova (sitting) of the Russian Space Agency. At the rear, from left, are Mission Specialist C. Michael Foale and Mission Specialist Jean-Francois Clervoy of the European Space Agency. STS-84 aboard the Space Shuttle Atlantis will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. After docking, Foale will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. STS-84 is targeted for a May 15 liftoff

STS-84 crew participates in TCDT activities

NASA Technical Reports Server (NTRS)

1997-01-01

STS-84 crew members ride in and learn how to operate an M-113 armored personnel carrier as part of the Terminal Countdown Demonstration Test (TCDT) activities. In the front seat is Pilot Eileen Marie Collins. George Hoggard, a training officer with KSC Fire Services, sits beside her on top of the personnel carrier. Directly behind Hoggard, from left, are Commander Charles J. Precourt and Mission Specialist Elena V. Kondakova (sitting) of the Russian Space Agency. At the rear, from left, are Mission Specialist C. Michael Foale and Mission Specialist Jean-Francois Clervoy of the European Space Agency. STS-84 aboard the Space Shuttle Atlantis will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. After docking, Foale will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. STS-84 is targeted for a May 15 liftoff.

STS-84 Day 08 Highlights

NASA Technical Reports Server (NTRS)

1995-01-01

On this eighth day of the STS-84 mission, the flight crew, Cmdr. Charles J. Precourt, Pilot Eileen M. Collins, Payload Cmdr, Jean-Francois Clervoy (ESA), Mission Specialists Edward T. Lu, Carlos I. Noriega, Elena V. Kondakova, Jerry M. Linenger (download), and C. Michael Foale (upload) sing 'The Cosmonauts' Song' to Mir-23 crew members Vasily Tsibliev, Alexander Lazutkin and astronaut Mike Foale, who is beginning his four-month research mission on Mir. Foale and his new crewmates played music as Atlantis departed following the joint phase of the flight. Atlantis' undocking from Mir was modified from previous joint missions in that a flyaround of the station for photographic purposes was not conducted. Instead, Pilot Eileen Collins guided Atlantis below the Mir after the two spacecraft completed their physical separation, stopping three times at distances of 90, 300 and 1,500 feet to collect data from a European sensor device designed to assist future rendezvous of a proposed European Space Agency resupply vehicle with the International Space Station. Once the data collection was completed, the shuttle took advantage of natural orbital mechanics to drift beneath and out in front of Mir.

STS-84 Mission Specialist C. Michael Foale in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist C. Michael Foale prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

jsc2017e049161

NASA Image and Video Library

2017-04-24

jsc2017e049161 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

jsc2017e049163

NASA Image and Video Library

2017-04-24

jsc2017e049163 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

jsc2017e049160

NASA Image and Video Library

2017-04-24

jsc2017e049160 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

jsc2017e049155

NASA Image and Video Library

2017-04-24

jsc2017e049155 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

jsc2017e049158

NASA Image and Video Library

2017-04-24

jsc2017e049158 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

jsc2017e049157

NASA Image and Video Library

2017-04-24

jsc2017e049157 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

jsc2017e049162

NASA Image and Video Library

2017-04-24

jsc2017e049162 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

jsc2017e049156

NASA Image and Video Library

2017-04-24

jsc2017e049156 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

jsc2017e049159

NASA Image and Video Library

2017-04-24

jsc2017e049159 (April 24, 2017) --- Flight Director Brian Smith, Capcom Astronaut Jessica Meir along with Astronaut Jeff Williams monitor activities in Mission Control as President Donald Trump, First Daughter Ivanka Trump and NASA astronaut Kate Rubins make a special Earth-to-space call from the Oval Office to personally congratulate NASA astronaut Peggy Whitson for her record-breaking stay aboard the International Space Station. (Photo Credit: NASA/Robert Markowitz)

KSC-03PD-2793

NASA Technical Reports Server (NTRS)

2003-01-01

Baikonur, Kazakhstan (Left to right) Expedition 8 Soyuz Commander and Flight Engineer Alexander Kaleri, Expedition 8 Commander Michael Foale, European Space Agency Astronaut Pedro Duque of Spain and Valery Korzun, chief of Cosmonauts, arrive in Baikonur. Expedition 8 is scheduled to launch from the Baikonur Cosmodrome in Kazakhstan on Oct. 18 on board a Soyuz rocket to the International Space Station. Photo Credit: 'NASA/Bill Ingalls'

STS-84 Day 07 Highlights

NASA Technical Reports Server (NTRS)

1995-01-01

On this seventh day of the STS-84 mission, the flight crew, Cmdr. Charles J. Precourt, Pilot Eileen M. Collions, Payload Cmdr, Jean-Francois Clervoy (ESA), Mission Specialists Edward T. Lu; Carlos I. Noriega; Elena V. Kondakova; Jerry M. Linenger (download) and C. Michael Foale (upload) are seen saying their final farewells and closing the hatches on their two spacecraft. This wrap up five days of joint operations in which about 7,000 pounds of supplies, experiments and water were transferred between the two vehicles, as well as astronaut Mike Foale, who swapped places with Jerry Linenger for the start of a four-month research mission on the Russian outpost. The final handshakes by Commanders Charlie Precourt and Vasily Tsibliev came moments before the hatches between Atlantis and Mir swung shut.

Mission Specialist Smith is suited and ready for launch

NASA Technical Reports Server (NTRS)

1999-01-01

In the Operations and Checkout Building, STS-103 Mission Specialist Steven L. Smith signals he is suited up and ready for launch. Other crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists C. Michel Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Jean-Frangois Clervoy of France and Claude Nicollier of Switzerland. Clervoy and Nicollier are with the European Space Agency. The STS-103 mission, to service the Hubble Space Telescope, is scheduled for launch Dec. 17 at 8:47 p.m. EST from Launch Pad 39B. Mission objectives include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. After the 8-day, 21-hour mission, Discovery is expected to land at KSC Sunday, Dec. 26, at about 6:30 p.m. EST.

STS-103 Mission Highlights Resource Tape (2 of 2)

NASA Technical Reports Server (NTRS)

2000-01-01

The STS-103 flight crew, Commander Curtis L. Brown, Pilot Scott J. Kelly, Mission Specialists Steven L. Smith, C. Michael Foale, John M. Grunsfeld, Claude Nicollier, and Jean-Francois Clervoy, are seen passing over the Yucatan and Florida Peninsulas. Smith and Grunsfeld replace and change the S-band single transmission cables during the third and final space walk of this mission. Crewmembers are also seen taking video documentation of the solar arrays. Footage presented includes the release of the Hubble Space Telescope, thruster firing and orbit adjust burn over the Central Indian Ocean and Australia. Also shown is the night landing of Discovery at Kennedy Space Center, crew departure from the vehicle, and short statements made by the crew. This is tape 2 of 2; tape 1 has a report number of NONP-NASA-VT-2000036030.

STS-82 training in WETF facility with Steve Smith and Mark Lee

NASA Image and Video Library

1996-06-10

S96-11807 (10 June 1996) --- Astronaut Steven L. Smith (right), STS-82 mission specialist assigned to extravehicular activity (EVA) involved with the servicing of the Hubble Space Telescope (HST), gets help with the final touches of suit donning from crewmate Joseph R. Tanner. Minutes later, Smith was underwater in a nearby tank and neutrally buoyant, rehearsing some of the HST servicing chores with a crewmate.

Living in Space

NASA Technical Reports Server (NTRS)

Brown, Ray (Editor)

1993-01-01

In this educational video from the 'Liftoff to Learning' series, astronauts from the STS-56 Mission (Ken Cockrell, Mike Foale, Ellen Ochoa, Steve Oswald, and Ken Cameron) explain and show through demonstrations how microgravity affects the way astronauts live onboard the Space Shuttle, and how these same daily habits or processes differ on Earth. A tour of the Space Shuttle is given, including the sleeping compartments, the kitchen area, the storage compartments, and the Waste Collection System (or WCS, as they call it). Daily habits (brushing teeth, shampooing hair and bathing, eating,...) are explained and actively illustrated, along with reasons of how these applications differ from their employment on Earth.

KSC-03PD-2795

NASA Technical Reports Server (NTRS)

2003-01-01

Baikonur, Kazakhstan (Left to right) European Space Agency Astronaut Pedro Duque of Spain, Expedition 8 Commander Michael Foale, and Expedition 8 Soyuz Commander and Flight Engineer Alexander Kaleri gather on the bus after the flight down from Moscow to Baikonur, Kazakhstan. Expedition 8 is scheduled to launch from the Baikonur Cosmodrome in Kazakhstan on Oct. 18 on board a Soyuz rocket to the International Space Station. Photo Credit: 'NASA/Bill Ingalls'

KSC-03PD-2794

NASA Technical Reports Server (NTRS)

2003-01-01

Baikonur, Kazakhstan Victor Grin (left), a member of the Russian State Commission, greets (left to right) Expedition 8 Commander Michael Foale, Expedition 8 Soyuz Commander and Flight Engineer Alexander Kaleri and European Space Agency Astronaut Pedro Duque of Spain. Expedition 8 is scheduled to launch from the Baikonur Cosmodrome in Kazakhstan on Oct.18 on board a Soyuz rocket to the International Space Station. Photo Credit: 'NASA/Bill Ingalls'

1st EVA - MS Smith and Grunsfeld during RSU changeout

NASA Image and Video Library

2000-01-26

STS103-331-013 (19-27 December 1999) --- Astronauts John M. Grunsfeld (right) and Steven L. Smith share space on the end of the remote manipulator system (RMS) as they change out gyroscopes, contained in rate sensor units (RSU) inside the Hubble Space Telescope (HST).

STS-86 Mission Specialist Wolf and friend visit LC 39A on L-1

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf waves to family members, friends and other well-wishers during a brief visit to Launch Pad 39A the day before the scheduled Sept. 25 launch aboard the Space Shuttle Atlantis. STS-86 is slated to be the seventh docking of the Space Shuttle with the Russian Space Station Mir. Wolf will be making his second spaceflight. After the docking, Wolf is scheduled to become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale. Wolf would remain on the Mir for about four months. Foale, who has been on the Mir since the STS- 84 mission in mid-May, will return to Earth with the remaining six members of the STS-86 crew at the end of the planned 10-day flight.

STS-86 Mission Specialist Wolf visits LC 39A on L-1

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf waves to family members, friends and other well-wishers during a brief visit to Launch Pad 39A the day before the scheduled Sept. 25 launch aboard the Space Shuttle Atlantis. STS-86 is slated to be the seventh docking of the Space Shuttle with the Russian Space Station Mir. Wolf will be making his second spaceflight. After the docking, Wolf is scheduled to become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale. Wolf would remain on the Mir for about four months. Foale, who has been on the Mir since the STS- 84 mission in mid-May, will return to Earth with the remaining six members of the STS-86 crew at the end of the planned 10-day flight.

International Space Station (ISS)

NASA Image and Video Library

2003-10-25

Aboard the International Space Station (ISS), European Space Agency astronaut Pedro Duque of Spain watches a water bubble float between a camera and himself. The bubble shows his reflection (reversed). Duque was launched aboard a Russian Soyuz TMA-3 spacecraft from the Baikonur Cosmodrome, Kazakhstan on October 18th, along with expedition-8 crew members Michael C. Foale, Mission Commander and NASA ISS Science Officer, and Cosmonaut Alexander Y. Kaleri, Soyuz Commander and flight engineer.

STS-110 crewmembers pose for photos in the Zvezda SM during Expedition Four

NASA Image and Video Library

2002-04-16

ISS004-E-10098 (16 April 2002) --- Astronaut Stephen N. Frick, STS-110 pilot, photographs crewmates in the Zvezda Service Module on the International Space Station (ISS). From the left are astronauts Michael J. Bloomfield, STS-110 mission commander, Jerry L. Ross and Lee M. E. Morin, both mission specialists. Astronaut Steven L. Smith, STS-110 mission specialist, floats above.

Astronaut Corps, STS-4 vehicle integration test team and other personnel

NASA Technical Reports Server (NTRS)

1982-01-01

Members of the JSC astronaut corps., STS-4 vehicle integration test team (VITT) and other personnel pose for a photograph at the completion of a countdown demonstration test (CDDT) at Launch pad 39A, Kennedy Space Center. Participants are, from the left: Wilbur J. Etbauer, engineer with the VITT; Mission Specialist/Astronaut James D. van Hoften; Terry Stanford, engineer from JSC's flight operations directorate; Mission Specialist/Astronaut Steven A. Hawley; Astronaut Richard N. Richards; Astronaut Michael J. Smith; Richard W. Nygren, head of the VITT; Mission Specialist/Astronaut Kathryn D. Sullivan; Astronaut Henry W. Hartsfield Jr., STS-4 pilot; Mary Haynes, a co-op student participating with the VITT; Astronaut Thomas K. Mattingly II., STS-4 commander; and Astronaut Donald E. Williams.

STS-84 M.S. Elena Kondakova at TCDT Press Briefing

NASA Technical Reports Server (NTRS)

1997-01-01

STS-84 Mission Specialist Elena V. Kondakova, a cosmonaut with the Russian Space Agency, talks to news media representatives and other onlookers during Terminal Countdown Demonstration Test (TCDT) activities at Launch Pad 39A. Kondakova will be one of seven crew members on the sixth docking of the Space Shuttle with the Russian Space Station Mir. Another of the crew members, C. Michael Foale, will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. Kondakova previously lived on the Russian space station as the flight engineer of the 17th main mission on Mir from Oct. 4, 1994, to March 9, 1995. STS-84 is targeted for a May 15 liftoff.

KSC-97pc757

NASA Image and Video Library

1997-04-29

STS-84 crew members ride in and learn how to operate an M-113 armored personnel carrier as part of the Terminal Countdown Demonstration Test (TCDT) activities. Seated inside the M-113, from left, are Mission Specialist Jean-Francois Clervoy, Pilot Eileen Marie Collins (waving) and Commander Charles J. Precourt, in front. George Hoggard, a training officer with KSC Fire Services, sits on top of the personnel carrier. STS-84 aboard the Space Shuttle Atlantis will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. After docking, STS-84 Mission Specialist C. Michael Foale will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. STS-84 is targeted for a May 15 liftoff

KSC-97pc736

NASA Image and Video Library

1997-04-28

STS-84 Mission Specialist Elena V. Kondakova, a cosmonaut with the Russian Space Agency, talks to news media representatives and other onlookers during Terminal Countdown Demonstration Test (TCDT) activities at Launch Pad 39A. Kondakova will be one of seven crew members on the sixth docking of the Space Shuttle with the Russian Space Station Mir. Another of the crew members, C. Michael Foale, will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. Kondakova previously lived on the Russian space station as the flight engineer of the 17th main mission on Mir from Oct. 4, 1994, to March 9, 1995. STS-84 is targeted for a May 15 liftoff

Expedition 8 Crew Interviews: C. Michael Foale - CDR

NASA Technical Reports Server (NTRS)

2003-01-01

C. Michael Foale, Commander of the Expedition 8 crew to the International Space Station (ISS), answers interview questions in this video. The questions cover: 1) The goals of the Expedition; 2) How his Mir experience prepared him for long-duration spaceflight; 3) The reaction the Columbia accident where he was training in Star City, Russia; 4) Why the rewards of spaceflight are worth the risks; 5) Why he wanted to become an astronaut; 6) His career path; 7) His influences; 8) His path of study; 9) His responsibilities on a mission; 10) What a Soyuz capsule is like; 11) What the oncoming and offgoing ISS crews will do together; 12) How the ISS science mission will be advanced during his stay; 13) Training and plans for extravehicular activity (EVA); 14) Return to Flight of Shuttle; 15) What is needed to make his mission a success; 16) The most valuable contribution of the ISS.

Bursch, Ross and Smith talk in Zvezda during STS-110's visit to the ISS

NASA Image and Video Library

2002-04-09

STS110-E-5122 (10 April 2002) --- Astronauts Daniel W. Bursch (left), Expedition Four flight engineer, Jerry L. Ross and Steven L. Smith, both STS-110 mission specialists, converse in the Zvezda Service Module on the International Space Station (ISS). The image was taken with a digital still camera.

KSC-97PC806

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist C. Michael Foale prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC851

NASA Image and Video Library

1997-05-24

The Space Shuttle orbiter Atlantis rolls out on Runway 33 of KSC’s Shuttle Landing Facility at the conclusion of the nine-day STS-84 mission. The Shuttle Training Aircraft piloted by astronaut Kenneth D. Cockrell, acting deputy chief of the Astronaut Office, is flying above Atlantis. The Vehicle Assembly Building is at left. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

KSC-97PC845

NASA Image and Video Library

1997-05-24

The Space Shuttle orbiter Atlantis, with its drag chute deployed, rolls out on Runway 33 of KSC’s Shuttle Landing Facility at the conclusion of the nine-day STS-84 mission. The Shuttle Training Aircraft piloted by astronaut Kenneth D. Cockrell, acting deputy chief of the Astronaut Office, is flying above Atlantis. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

Mission commander James Wetherbee on the forward flight deck

NASA Image and Video Library

1995-02-03

STS063-06-027 (3-11 Feb 1995) --- Seated at the commander's station on the Space Shuttle Discovery's flight deck, astronaut James D. Wetherbee, commander, was photographed by a crew mate during early phases of the STS-63 mission. A great deal of time was spent during the first few days of the mission to check a leaky thruster, which could have had a negative influence on rendezvous operations with Russia's Mir Space Station. As it turned out, all the related problems were solved and the two spacecraft succeded in achieving close proximity operations. Others onboard the Discovery were astronauts Eileen M. Collins, pilot; Bernard A. Harris Jr., payload commander; and mission specialists C. Michael Foale, Janice E. Voss, and Russian cosmonaut Vladimir G. Titov.

KSC-97PC847

NASA Image and Video Library

1997-05-24

NASA Administrator Daniel Goldin presents some gifts to returning astronaut Jerry M. Linenger, who spent the last four months on the Russian Space Station Mir. Goldin met with Linenger in the Crew Transport Vehicle shortly after the Space Shuttle orbiter Atlantis landed on Runway 33 of KSC’s Shuttle Landing Facility at the conclusion of the nine-day STS-84 mission. Goldin gave the astronaut flowers for Linenger’s wife, Kathryn; a stuffed bear for their 18-month-old son, John; and a rattle for their unborn child who is due next month. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Mir. Mir 23 crew member Linenger was replaced on the Russian space station by STS-84 Mission Specialist C. Michael Foale

STS-103 crew wait inside Discovery for simulated countdown exercise

NASA Technical Reports Server (NTRS)

1999-01-01

STS-103 Mission Specialists Jean-Fran'''ois Clervoy of France takes his seat inside the Space Shuttle Discovery during a practice launch countdown, part of Terminal Countdown Demonstration Test (TCDT) activities, while astronaut David 'Doc' Brown checks him out. The TCDT also provides the crew with emergency egress training and opportunities to inspect their mission payload in the orbiter's payload bay. Other crew members taking part in the TCDT are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland. Clervoy and Nicollier are with the European Space Agency. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

KSC-02pp0020

NASA Image and Video Library

2001-12-01

JOHNSON SPACE CENTER, HOUSTON, TEXAS. -- STS-110 CREW PORTRAIT -- (JSC STS110-5-002) -- These seven astronauts are in training for the STS-110 mission, scheduled to visit the International Space Station early next year. In front, from the left, are astronauts Stephen N. Frick, pilot; Ellen Ochoa, flight engineer; and Michael J. Bloomfield, mission commander; in the back, from left, are astronauts Steven L. Smith, Rex J. Walheim, Jerry L. Ross and Lee M.E. Morin, all mission specialists

STS-63 crew portrait

NASA Technical Reports Server (NTRS)

1994-01-01

With the United States and Russian flags in the background, five NASA astronauts and a Russian cosmonaut named to fly aboard the Space Shuttle Discovery for the the STS-63 mission pose for the flight crew portrait at JSC. Left to right (front row) are Janice E. Voss, mission specialist, Eileen M. Collins, pilot; James D. Wetherbee, mission commander; and Vladimir Titov of the Russian Space Agency, mission specialist. In the rear are Bernard A. Harris Jr., payload commander; and C. Michael Foale, mission specialist.

Landing of STS-63 Discovery at KSC

NASA Image and Video Library

1995-02-11

STS063-S-015 (11 Feb. 1995) --- The Space Shuttle Discovery deploys its drag chute on Runway 15 at the Kennedy Space Center's (KSC) Shuttle Landing Facility as it wraps up an eight-day mission. Touchdown occurred at 6:50:19 a.m. (EST), February 11, 1995. Onboard the Space Shuttle Discovery were astronauts James D. Wetherbee, mission commander; Eileen M. Collins, pilot; Bernard A. Harris Jr., payload commander; mission specialists C. Michael Foale, Janice E. Voss, and cosmonaut Vladimir G. Titov.

Expedition-8 Flight Members Pose Inside the Soyuz TMA-3 Vehicle

NASA Technical Reports Server (NTRS)

2003-01-01

Posed inside the Soyuz TMA-3 Vehicle in a processing facility at the Baikonur Cosmodrome in Kazakhstan during a pre-launch inspection are (left to right): Expedition-8 Crew members, Michael C. Foale, Mission Commander and NASA ISS Science Officer; Cosmonaut Alexander Y. Kaleri, Soyuz Commander and flight engineer; and European Space Agency (ESA) astronaut Pedro Duque of Spain. The three launched from the Cosmodrome on October 18, 2003 onboard a Soyuz rocket destined for the International Space Station (ISS).

STS-103 Crew Interviews: Steven Smith

NASA Technical Reports Server (NTRS)

1999-01-01

Live footage of a preflight interview with Mission Specialist Steven L. Smith is seen. The interview addresses many different questions including why Brown became an astronaut, the events that led to his interest, any role models that he had, and his inspiration. Other interesting information that this one-on-one interview discusses is an explanation of the why this required mission to service the Hubble Space Telescope must take place at such an early date, replacement of the gyroscopes, transistors, and computers. Also discussed is Smith's responsibility during any of the planned space walks scheduled for this mission.

KSC-97pc782

NASA Image and Video Library

1997-05-11

STS-84 Mission Specialist Elena V. Kondakova, a cosmonaut with the Russian Space Agency, and her husband, Valery Ryumin, greet press represenatives and other well wishers after her arrival at KSC’s Shuttle Landing Facility. Ryumin is director of the Mir-Shuttle program for RSC Energia in Russia. This will be Kondakova’s first flight on a U.S. Space Shuttle, but her second trip into space. She spent 169 days in space as flight engineer of the 17th main mission on Mir from October 1994 to March 1995. STS-84 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. During the docking, STS-84 Mission Specialist C. Michael Foale will transfer to the Russian space station to become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth on Atlantis. Foale is scheduled to remain on Mir about four months until his replacement arrives on STS-86 in September

STS-84 crew members in M-113 armored carrier for TCDT

NASA Technical Reports Server (NTRS)

1997-01-01

STS-84 crew members ride in and learn how to operate an M-113 armored personnel carrier as part of the Terminal Countdown Demonstration Test (TCDT) activities. Seated inside the M-113, from left, are Mission Specialist Jean-Francois Clervoy, Pilot Eileen Marie Collins (waving) and Commander Charles J. Precourt, in front. George Hoggard, a training officer with KSC Fire Services, sits on top of the personnel carrier. STS-84 aboard the Space Shuttle Atlantis will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. After docking, STS-84 Mission Specialist C. Michael Foale will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. STS-84 is targeted for a May 15 liftoff.

STS-84 M.S. Kondakova with husband Ryumin at SLF

NASA Technical Reports Server (NTRS)

1997-01-01

STS-84 Mission Specialist Elena V. Kondakova, a cosmonaut with the Russian Space Agency, and her husband, Valery Ryumin, greet press represenatives and other well wishers after her arrival at KSCs Shuttle Landing Facility. Ryumin is director of the Mir- Shuttle program for RSC Energia in Russia. This will be Kondakovas first flight on a U.S. Space Shuttle, but her second trip into space. She spent 169 days in space as flight engineer of the 17th main mission on Mir from October 1994 to March 1995. STS-84 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. During the docking, STS-84 Mission Specialist C. Michael Foale will transfer to the Russian space station to become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth on Atlantis. Foale is scheduled to remain on Mir about four months until his replacement arrives on STS-86 in September.

STS-84 / Mir 23 Crew Member Jerry Linenger post landing

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FL - Astronaut and recent Mir 23 crew member Jerry M. Linenger holds a stuffed bear he was given by NASA Administrator Daniel Goldin at the conclusion of the STS-84 Space Shuttle mission. STS-84 was the sixth docking of the Shuttle with the Russian Space Station Mir, where Linenger has lived and worked the past four months. Goldin presented several gifts to Linenger in the Crew Transport Vehicle shortly after landing of the Space Shuttle orbiter Atlantis on KSC's Runway 33. Besides the bear for Linenger's 18-month-old son, John, Goldin gave the astronaut flowers for Linenger's wife, Kathryn; and a rattle for the Linengers' unborn child who is due next month. Linenger was replaced on the Russian space station by STS-84 Mission Specialist C. Michael Foale.

KSC-97PC848

NASA Image and Video Library

1997-05-24

Astronaut and recent Mir 23 crew member Jerry M. Linenger holds a stuffed bear he was given by NASA Administrator Daniel Goldin at the conclusion of the STS-84 Space Shuttle mission. STS-84 was the sixth docking of the Shuttle with the Russian Space Station Mir, where Linenger has lived and worked the past four months. Goldin presented several gifts to Linenger in the Crew Transport Vehicle shortly after landing of the Space Shuttle orbiter Atlantis on KSC’s Runway 33. Besides the bear for Linenger’s 18-month-old son, John, Goldin gave the astronaut flowers for Linenger’s wife, Kathryn; and a rattle for the Linengers’ unborn child who is due next month. Linenger was replaced on the Russian space station by STS-84 Mission Specialist C. Michael Foale

STS-84 post landing - Dan Goldin presents gifts to Linenger

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FL - NASA Administrator Daniel Goldin presents some gifts to returning astronaut Jerry M. Linenger, who spent the last four months on the Russian Space Station Mir. Goldin met with Linenger in the Crew Transport Vehicle shortly after the Space Shuttle orbiter Atlantis landed on Runway 33 of KSC's Shuttle Landing Facility at the conclusion of the nine-day STS-84 mission. Goldin gave the astronaut flowers for Linenger's wife, Kathryn; a stuffed bear for their 18-month-old son, John; and a rattle for their unborn child who is due next month. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Mir. Mir 23 crew member Linenger was replaced on the Russian space station by STS-84 Mission Specialist C. Michael Foale.

STS-82 Suit-up for Post Insertion Training in Crew Compartment Trainer 2

NASA Image and Video Library

1996-10-30

S96-18563 (30 Oct. 1996) --- Astronaut Steven L. Smith, mission specialist, participates in a training session in JSC's systems integration facility. Wearing training versions of the partial pressure launch and entry escape suit, Smith and his crewmates simulated an emergency ejection, using the escape pole (left center in hatchway) on the mid deck, as well as other phases of their scheduled February mission.

STS-110 Crew Interviews: Steve Smith

NASA Technical Reports Server (NTRS)

2002-01-01

STS-110 Mission Specialist Steve Smith is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. Smith outlines his role in the mission in general, and specifically during the docking and extravehicular activities (EVAs). He describes the payload (S0 Truss and Mobile Transporter) and the dry run installation of the S0 truss that will take place the day before the EVA for the actual installation. Smith discusses the planned EVAs in detail and outlines what supplies will be left for the resident crew of the International Space Station (ISS). He ends with his thoughts on the most valuable aspect of the ISS.

KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush from NASA Headquarters stating his goals for NASA’s new mission. Seated in the front row, left to right, are Ken Aguilar, chief, Equal Opportunity office; Lisa Malone, director of External Affairs; Bruce Buckingham, assistant to Dr. Woodrow Whitlow, KSC deputy director; Dr. Whitlow; Shannon Roberts, with External Affairs; Howard DeCastro, vice president and Space Shuttle program manager, United Space Alliance; and Bill Pickavance vice president and associate program manager of Florida Operations, USA. The President’s goals are completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

NASA Image and Video Library

2004-01-14

KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush from NASA Headquarters stating his goals for NASA’s new mission. Seated in the front row, left to right, are Ken Aguilar, chief, Equal Opportunity office; Lisa Malone, director of External Affairs; Bruce Buckingham, assistant to Dr. Woodrow Whitlow, KSC deputy director; Dr. Whitlow; Shannon Roberts, with External Affairs; Howard DeCastro, vice president and Space Shuttle program manager, United Space Alliance; and Bill Pickavance vice president and associate program manager of Florida Operations, USA. The President’s goals are completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

Dr. David Brown poses with students at Ronald McNair Middle School

NASA Technical Reports Server (NTRS)

1999-01-01

Dr. David Brown (right), a NASA astronaut, poses with students in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. From left, the students are Kristin Rexford, Danitra Anderson, Dominique Smith, Fallon Davis, and Qiana Taylor. Brown was at the school to attend a tribute to NASA astronaut Ronald McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven, who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

International Space Station (ISS)

NASA Image and Video Library

2003-10-16

The Soyuz TMA-3 spacecraft and its booster rocket (rear view) is shown on a rail car for transport to the launch pad where it was raised to a vertical launch position at the Baikonur Cosmodrome, Kazakhstan on October 16, 2003. Liftoff occurred on October 18th, transporting a three man crew to the International Space Station (ISS). Aboard were Michael Foale, Expedition-8 Commander and NASA science officer; Alexander Kaleri, Soyuz Commander and flight engineer, both members of the Expedition-8 crew; and European Space agency (ESA) Astronaut Pedro Duque of Spain. Photo Credit: "NASA/Bill Ingalls"

International Space Station (ISS)

NASA Image and Video Library

2003-10-16

The Soyuz TMA-3 spacecraft and its booster rocket (front view) is shown on a rail car for transport to the launch pad where it was raised to a vertical launch position at the Baikonur Cosmodrome, Kazakhstan on October 16, 2003. Liftoff occurred on October 18th, transporting a three man crew to the International Space Station (ISS). Aboard were Michael Foale, Expedition-8 Commander and NASA science officer; Alexander Kaleri, Soyuz Commander and flight engineer, both members of the Expedition-8 crew; and European Space agency (ESA) Astronaut Pedro Duque of Spain. Photo Credit: "NASA/Bill Ingalls"

KSC-97PC857

NASA Image and Video Library

1997-05-24

Astronaut and recent Mir 23 crew member Jerry M. Linenger poses for a photograph with his wife, Kathryn, and their 18-month-old son, John, during a family reunion in the Operations and Checkout Building. Kathryn Linenger is expecting their second child next month. Linenger just returned to Earth after a four-month stay on the Russian Space Station Mir. He flew back on Atlantis with six other members of the STS-84 crew, who conducted the sixth Space Shuttle docking with the Mir. STS-84 Mission Specialist C. Michael Foale replaced Linenger on the Mir

Various views of the STS-86 orbiter Atlantis landing at KSC

NASA Image and Video Library

1998-06-12

STS086-S-014 (6 Oct 1997) --- The main landing gear of the Space Shuttle Atlantis is about to touch down on the Kennedy Space Center's (KSC) Shuttle Landing Facility to complete the STS-86 mission. Touchdown occurred at 5:55:09 p.m. (EDT), October 6, 1997. Onboard were astronauts James D. Wetherbee, Michael J. Bloomfield, Wendy B. Lawrence, Scott F. Parazynski, Vladimir G. Titov, C. Michael Foale and Jean-Loup J. M. Chretien. Chretien and Titov represent the French Space Agency (CNES) and the Russian Space Agency (RSA), respectively.

Expedition-8 Crew Members Portrait

NASA Technical Reports Server (NTRS)

2003-01-01

This is a portrait of the Expedition-8 two man crew. Pictured left is Cosmonaut Alexander Y, Kaleri, Soyuz Commander and flight engineer; and Michael C. Foale (right), Expedition-8 Mission Commander and NASA ISS Science Officer. The crew posed for this portrait while training at the Gagarin Cosmonaut Training Center in Star City, Russia. The two were launched for the International Space Station (ISS) aboard a Soyuz TMA-3 spacecraft from the Baikonur Cosmodrome, Kazakhstan, along with European Space Agency (ESA) Astronaut Pedro Duque of Spain, on October 18, 2003.

Various views of the STS-86 orbiter Atlantis landing at KSC

NASA Image and Video Library

1998-06-12

STS086-S-013 (6 Oct 1997) --- The main landing gear of the Space Shuttle Atlantis is about to touch down on the Kennedy Space Center?s (KSC) Shuttle Landing Facility to complete the STS-86 mission. Touchdown occurred at 5:55:09 p.m. (EDT), October 6, 1997. Onboard were astronauts James D. Wetherbee, Michael J. Bloomfield, Wendy B. Lawrence, Scott F. Parazynski, Vladimir G. Titov, C. Michael Foale and Jean-Loup J. M. Chretien. Chretien and Titov represent the French Space Agency (CNES) and the Russian Space Agency (RSA), respectively.

View of the STS-86 orbiter Atlantis landing at KSC

NASA Image and Video Library

1998-06-12

STS086-S-015 (6 Oct 1997) --- The main landing gear of the Space Shuttle Atlantis touches down on the Kennedy Space Center?s (KSC) Shuttle Landing Facility to complete the STS-86 mission. Touchdown occurred at 5:55:09 p.m. (EDT), October 6, 1997. Onboard were astronauts James D. Wetherbee, Michael J. Bloomfield, Wendy B. Lawrence, Scott F. Parazynski, Vladimir G. Titov, C. Michael Foale and Jean-Loup J. M. Chretien. Chretien and Titov represent the French Space Agency (CNES) and the Russian Space Agency (RSA), respectively.

KSC-97PC844

NASA Image and Video Library

1997-05-24

Framed by the Vehicle Assembly Building in the distance, at left, and the Mate-Demate Device, the Space Shuttle Atlantis with its drag chute deployed touches down on KSC’s Runway 33 at the conclusion of the STS-84 mission. The Shuttle Training Aircraft with astronaut Kenneth D. Cockrell at the controls is flying in front of Atlantis. Cockrell is acting deputy chief of the Astronaut Office. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and Jean-Francois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

STS 63: Post Flight Presentation

NASA Technical Reports Server (NTRS)

1995-01-01

At a post flight conference, Captain Jim Wetherbee, of STS Flight 63, introduces each of the other members of the STS 63 crew (Eileen Collins, Pilot; Dr. Bernard Harris, Payload Commander; Dr. Michael Foale, Mission Specialist from England; Dr. Janice Voss, Misssion Specialist; and Colonel Vladimir Titor, Misssion Specialist from Russia. A short biography of each member and a brief description of their assignment during this mission is given. A film was shown that included the preflight suit-up, a view of the launch site, the actual night launch, a tour of the Space Shuttle and several of the experiment areas, several views of earth and the MIR Space Station and cosmonauts, the MIR-Space Shuttle rendezvous, the deployment of the Spartan Ultraviolet Telescope, Foale and Harris's EVA and space walk, the retrieval of Spartan, and the night entry home, including the landing. Several spaceborne experiments were introduced: the radiation monitoring experiment, environment monitoring experiment, solid surface combustion experiment, and protein crystal growth and plant growth experiments. This conference ended with still, color pictures, taken by the astronauts during the entire STS 63 flight, being shown.

STS 63: Post flight presentation

NASA Astrophysics Data System (ADS)

1995-02-01

At a post flight conference, Captain Jim Wetherbee, of STS Flight 63, introduces each of the other members of the STS 63 crew (Eileen Collins, Pilot; Dr. Bernard Harris, Payload Commander; Dr. Michael Foale, Mission Specialist from England; Dr. Janice Voss, Mission Specialist; and Colonel Vladimir Titor, Mission Specialist from Russia), gave a short autobiography of each member and a brief description of their assignment during this mission. A film was shown that included the preflight suit-up, a view of the launch site, the actual night launch, a tour of the Space Shuttle and several of the experiment areas, several views of earth and the MIR Space Station and cosmonauts, the MlR-Space Shuttle rendezvous, the deployment of the Spartan Ultraviolet Telescope, Foale and Harris's EVA and space walk, the retrieval of Spartan, and the night entry home, including the landing. Several spaceborne experiments were introduced: the radiation monitoring experiment, environment monitoring experiment, solid surface combustion experiment, and protein crystal growth and plant growth experiments. This conference ended with still, color pictures, taken by the astronauts during the entire STS 63 flight, being shown.

STS-86 crew members Wolf and Lawrence at SLF for TCDT

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialists Wendy B. Lawrence, at left, and David A. Wolf confer -- possibly about the Russian Space Station Mir? - - after their arrival at KSCs Shuttle Landing Facility for the Terminal Countdown Demonstration Test (TCDT). Lawrence was supposed to be the next U.S. astronaut slated for a long-duration stay aboard Mir, but was replaced by Wolf in late July. Unlike Lawrence, Wolf has undergone spacewalk training and fits in the Orlan spacesuit used by Russians on spacewalks. Lawrence will remain on the STS-86 crew, but will return to Earth at the conclusion of the planned 10-day mission. Wolf will take the place on Mir of astronaut C. Michael Foale, who arrived on the Russian space station during the STS-84 mission in May. STS-86 will be the seventh docking of the Space Shuttle with the Mir. The mission is targeted for a Sept. 25 launch aboard the Space Shuttle Atlantis.

STS-103 Mission Specialist Foale and his family DEPART PAFB for Houston

NASA Technical Reports Server (NTRS)

1999-01-01

STS-103 Mission Specialist C. Michael Foale (Ph.D.) holds one of his children on the runway at Patrick Air Force Base in Cocoa Beach, Fla., as his wife, Rhonda, looks on. The STS-103 crew and their families are preparing to board an airplane that will return them to their home base at the Johnson Space Center in Houston following the successful completion of their mission. Discovery landed in darkness the previous evening, Dec. 27, on runway 33 at KSC's Shuttle Landing Facility at 7:00:47 p.m. EST. This was the first time that a Shuttle crew spent the Christmas holiday in space. The other STS-103 crew members are Commander Curtis L. Brown Jr.; Pilot Scott J. Kelly; and Mission Specialists Steven L. Smith, John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France. The STS-103 mission accomplished outfitting the Hubble Space Telescope with six new gyroscopes, six new voltage/temperature improvement kits, a new onboard computer, a new solid state recorder and new data transmitter, a new fine guidance sensor along with new insulation on parts of the orbiting telescope. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery.

Neonatal isoerythrolysis in horse foals and a mule foal: 18 cases (1988-2003).

PubMed

Boyle, Ashley G; Magdesian, K Gary; Ruby, Rebecca E

2005-10-15

To assess data regarding clinical features, clinicopathologic and blood gas variables, and outcome from horse and mule foals with confirmed neonatal isoerythrolysis (NI). Retrospective case series. 17 horse and 1 mule foals. Medical records of foals (< 14 days old) with NI were reviewed. Information collected included signalment; clinical examination findings; results of hematologic, serum and plasma biochemical, and venous blood gas analyses and urinalysis; treatments; and outcome. Data from 17 horse foals and 1 mule foal with NI (mean age, 71 hours) were evaluated. Many foals had high serum indirect and direct bilirubin concentrations and sorbitol dehydrogenase activity. Whole blood immunoglobulin concentrations were < 400 mg/dL in 4 of 15 foals. Fresh whole blood transfusions were administered to 10 of 18 foals. Among the blood factors implicated in 11 foals, one (Dg) had not previously been associated with NI. Of 10 foals that received blood transfusions, 7 had significant improvements in Hct and hemoglobin concentration and 2 had significant improvements in central venous oxygen tension. Fifteen foals survived to discharge. Data suggest that blood factor Dg may be associated with NI in foals. Liver disease may be concurrent with NI in foals, and NI can develop in foals with inadequate passive transfer of colostral antibodies. Whole blood transfusions were successful at increasing oxygen-carrying capacity and improving peripheral tissue oxygenation in NI-affected foals. With appropriate treatment, the prognosis for foals with NI is good.

Importance of milk replacer intake and composition in rearing orphan foals

PubMed Central

Cymbaluk, Nadia F.; Smart, Marion E.; Bristol, Frank M.; Pouteaux, Victor A.

1993-01-01

Effects of milk replacer composition and intake on the growth of orphan foals were evaluated. Twenty foals were assigned to four treatments: 1) mare-nursed, 2) commercial foal milk replacer at recommended intakes (standard), 3) commercial foal milk replacer at high intakes (high), and 4) acidified replacer at recommended intakes (acidified). Foals fed milk replacer diets were weaned at 12-24 hours postpartum and fed milk replacer for 50 days. Mare-nursed foals were weaned between 52 and 56 days of age. Foals fed replacer diets gained 12% to 28% less weight than mare-nursed foals up to two weeks of age. However, by four months of age, weights of replacer-fed foals were similar to those of mare-nursed foals and 32 other mare-nursed foals at the farm weaned between three and four months postparium. Foals drank 10 to 12 L/100 kg body weight (BW) in fluid replacer daily over the trial period. During the first week, high intake foals consumed 26% more replacer (p<0.05) than foals fed acidified or standard diets. This higher intake resulted in diarrhea earlier (6-11 days vs 11-22 days) and for a longer time (6.3 days vs 2.5-3.6 days) than in foals fed recommended amounts. Mare-nursed foals developed “foal heat scours” in the second week postpartum. After the first week, foals fed high replacer diet voluntarily consumed the same volume of fluid replacer as foals fed the standard intake. Foals ate less than 1 kg grain mix/100 kg BW daily to one month of age, then increased intake to 1.5-2 kg/ 100 kg BW to weaning. Water intake was 20-40% of daily fluid intake and was correlated (r = 0.85) to dry matter intake. Foals in the high intake group ate less (p<0.05) solid feed and drank less water than foals fed the standard and acidified diets. The foal's stomach capacity appears to limit meal size and thus replacer intake. If recommended feeding intervals are used, replacer intakes by foals are less than 15% BW daily. High volume intakes appeared to prolong diarrhea. Normal growth rates occur when replacer and good-quality feeds are fed concurrently. PMID:17424268

STS-84 Commander Charles Precourt arriving for TCDT

NASA Technical Reports Server (NTRS)

1997-01-01

STS-84 Commander Charles J. Precourt arrives at KSCs Shuttle Landing Facility for the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. Precourt will lead the six other crew members when they travel to Mir next month aboard the Space Shuttle Atlantis. STS-84 Mission Specialist C. Michael Foale will be dropped off on Mir to become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth on Atlantis after about four months on the orbiting station. STS-84 will be the sixth Shuttle-Mir docking. Liftoff is targeted for May 15.

STS-84 Crew inspect tires after Landing

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FL - STS-84 crew members, from left, Mission Specialist Carlos I. Noriega, Commander Charles J. Precourt and Mission Specialist Jean-Francois Clervoy examine the tires of the Space Shuttle Atlantis after landing. Atlantis traveled about 3.6 million miles during the nine-day mission, which was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. The mission also included the exchange of STS-84 Mission Specialist C. Michael Foale for astronaut and Mir 23 crew member, Jerry M. Linenger, who spent the last four months on the Russian space station.

Launch of STS-63 Discovery

NASA Image and Video Library

1995-02-03

STS063-S-007 (3 Feb 1995) --- The race to catch up with the Russia's Mir gets underway as the Space Shuttle Discovery launches from Pad 39B, Kennedy Space Center (KSC) at 12:22:04 (EST), February 3, 1995. Discovery is the first in the current fleet of four Space Shuttle vehicles to make 20 launches. Onboard for the 67th (STS-63 is out of sequence) Shuttle flight are astronauts James D. Wetherbee, mission commander; Eileen M. Collins, pilot; Bernard A. Harris Jr., payload commander; mission specialists Janice Voss and C. Michael Foale; along with Russian cosmonaut Vladimir G. Titov.

Soyuz Spacecraft Transported to Launch Pad

NASA Technical Reports Server (NTRS)

2003-01-01

The Soyuz TMA-3 spacecraft and its booster rocket (front view) is shown on a rail car for transport to the launch pad where it was raised to a vertical launch position at the Baikonur Cosmodrome, Kazakhstan on October 16, 2003. Liftoff occurred on October 18th, transporting a three man crew to the International Space Station (ISS). Aboard were Michael Foale, Expedition-8 Commander and NASA science officer; Alexander Kaleri, Soyuz Commander and flight engineer, both members of the Expedition-8 crew; and European Space agency (ESA) Astronaut Pedro Duque of Spain. Photo Credit: 'NASA/Bill Ingalls'

Soyuz Spacecraft Transported to Launch Pad

NASA Technical Reports Server (NTRS)

2003-01-01

The Soyuz TMA-3 spacecraft and its booster rocket (rear view) is shown on a rail car for transport to the launch pad where it was raised to a vertical launch position at the Baikonur Cosmodrome, Kazakhstan on October 16, 2003. Liftoff occurred on October 18th, transporting a three man crew to the International Space Station (ISS). Aboard were Michael Foale, Expedition-8 Commander and NASA science officer; Alexander Kaleri, Soyuz Commander and flight engineer, both members of the Expedition-8 crew; and European Space agency (ESA) Astronaut Pedro Duque of Spain. Photo Credit: 'NASA/Bill Ingalls'

Demonstrative Maneuvers for Aircraft Agility Predictions

DTIC Science & Technology

2008-03-01

AIAA Paper 1996-3741. 19. Raymer , Daniel P. Aircraft Design: A Conceptual Approach. American Institute of Aeronautics and Astronautics, Inc., 3rd...Shaw, Robert L. Fighter Combat: Tactics and Maneuvering. Naval Institute Press, Annapolis, MD, 1985. 25. Smith, Steven W. The Scientist and

Ultrasonographic assessment of the atlanto-occipital space in healthy Thoroughbred foals and Thoroughbred foals with neonatal maladjustment syndrome.

PubMed

Mackenzie, C J; Haggett, E F; Pinchbeck, G L; Marr, C M

2017-05-01

Ultrasonography of the atlanto-occipital (AO) space may be useful as a non-invasive diagnostic tool in neonatal foals. The aims of the study were establish a range of values for ultrasonographic measurements of the AO space in healthy Thoroughbred foals and to compare these variables in healthy foals with foals diagnosed with neonatal maladjustment syndrome (NMS). Ultrasonography of the AO space was performed on 38 healthy Thoroughbred foals and 28 Thoroughbred foals with NMS≤4days of age. Transverse image spinal cord height (P=0.001), width (P<0.001) and spinal cord cross sectional area (P<0.001), and longitudinal image dorsoventral diameter of the ventral spinal artery, were significantly smaller in foals with NMS than in healthy foals. Ratios of spinal canal to cord width and cross sectional area were significantly smaller in healthy foals than in foals with NMS (P<0.001). Spinal canal variables were not significantly different between groups. Several ultrasonographic measurements of the AO space were significantly different between healthy foals and foals with NMS. Further investigation is warranted to investigate the clinical application of this technique. Copyright © 2017 Elsevier Ltd. All rights reserved.

STS-84 Commander Charles J. Precourt in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Commander Charles J. Precourt prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

Atlantis lifts off on mission STS-84

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC803

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Pilot Eileen Marie Collins in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Pilot Eileen M. Collins prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC811

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist Jean-Francois Clervoy prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC800

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC807

NASA Image and Video Library

1997-05-15

STS-84 Commander Charles J. Precourt prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC802

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC810

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist Carlos I. Noriega prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Mission Specialist Jean-Francois Clervoy in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Jean- Francois Clervoy prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC808

NASA Image and Video Library

1997-05-15

STS-84 Pilot Eileen M. Collins prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Mission Specialist Edward Tsang Lu in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Edward T. Lu prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC804

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC809

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist Edward T. Lu prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Liftoff (across water)

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Mission Specialist Elena V. Kondakova in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Elena V. Kondakova prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC801

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Mission Specialist Carlos I. Noriega in white room

NASA Technical Reports Server (NTRS)

1997-01-01

KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist Carlos I. Noriega prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Shuttle Atlantis Liftoff

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

KSC-97PC805

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC812

NASA Image and Video Library

1997-05-15

STS-84 Mission Specialist Elena V. Kondakova prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC799

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

KSC-97PC798

NASA Image and Video Library

1997-05-15

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew

STS-84 Night Launch (left view)

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Night Launch (front view)

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-84 Night Launch (side view)

NASA Technical Reports Server (NTRS)

1997-01-01

The Space Shuttle Atlantis turns night into day for a few moments as it lifts off on May 15 at 4:07:48 a.m. EDT from Launch Pad 39A on the STS-84 mission. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

STS-103 M.S. Steven Smith during TCDT activities

NASA Technical Reports Server (NTRS)

1999-01-01

STS-103 Mission Specialist Steven L. Smith gets ready to practice driving a small armored personnel carrier that is part of emergency egress training during Terminal Countdown Demonstration Test (TCDT) activities. The tracked vehicle could be used by the crew in the event of an emergency at the pad during which the crew must make a quick exit from the area. The TCDT also provides simulated countdown exercises and opportunities to inspect the mission payloads in the orbiter's payload bay. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The other STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists John M. Grunsfeld (Ph.D.), C. Michael Foale (Ph.D.), (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, who are with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

KSC-97PC863

NASA Image and Video Library

1997-05-25

KENNEDY SPACE CENTER, FLA. - Members of the STS-84 crew pause at Patrick Air force Base just prior to their departure for Johnson Space Center in Houston, Texas. They are (from left) Mission Specialist Jean-Francois Clervoy; returning astronaut and Mir 23 crew member Jerry M. Linenger; Mission Commander Charles J. Precourt; Mission Specialist Edward Tsang Lu; and Mission Specialist Elena V. Kondakova. The seven-member crew returned aboard the Space Shuttle Orbiter Atlantis May 24 on KSC's Runway 33 after the completion of a successful nine-day mission. STS-84 was the sixth docking of the Space Shuttle with the Russian Space Station MIr. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced Linenger, who had been on the Russian space station since Jan. 15. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale's stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences.

Effects of repeated Strongylus vulgaris inoculations and concurrent ivermectin treatments on mesenteric arterial lesions in pony foals.

PubMed

Klei, T R; Turk, M A; McClure, J R; Holmes, R A; Dennis, V A; Chapman, M R

1990-04-01

Eight of 10 pony foals reared under helminth-free conditions were inoculated PO with 50 Strongylus vulgaris infective larvae/week for 4 weeks, at which time 1 foal died of acute verminous arteritis. Inoculation of 7 remaining foals continued at 2-week intervals for 20 weeks. Of the 7 foals, 3 were treated with ivermectin (0.2 mg/kg of body weight) in an oral paste formulation at experiment weeks 8, 16, 24; 4 foals were not treated. Two foals were not inoculated or treated and served as controls. After the first ivermectin treatment, ivermectin-treated foals had fewer days (12 +/- 2.9) with rectal temperatures greater than 38.6 C than did nontreated foals (23.3 +/- 3.8). Mean baseline rectal temperatures were 38 +/- 0.2 C. Adverse clinical reactions to ivermectin treatment were not observed in foals. Foals were euthanatized and necropsied 3 weeks after the last ivermectin treatment (week 24). Ivermectin was effective in reducing S vulgaris arterial larval and intestinal adult parasite numbers by 100% in 3 treated foals. Strongylus vulgaris arterial larvae and/or adults were recovered from all 4 nontreated inoculated foals. One nontreated inoculated foal lacked arterial larvae or active arterial lesions, indicating that protective resistance had developed in this individual. Marked gross and histopathologic lesions typical of chronic S vulgaris infection were observed in the 3 nontreated inoculated foals with arterial larvae. Repeated killing of intra-arterial S vulgaris fourth-stage larvae in ivermectin-treated foals did not exacerbate lesions associated with verminous arteritis or induce unique lesions associated with repeated destruction of arterial larvae.(ABSTRACT TRUNCATED AT 250 WORDS)

Persistent frenulum of the epiglottis in four foals.

PubMed

Yarbrough, T B; Voss, E; Herrgesell, E J; Shaw, M

1999-01-01

To report the clinical signs and management of 4 foals with persistent frenulum of the epiglottis. Case report. Four newborn foals. Foals were admitted with a complaint of oronasal reflux after nursing. Variable systemic signs of aspiration pneumonia were evident. Nasal endoscopy confirmed persistent dorsal displacement of the soft palate. Persistent frenulum of the epiglottis, confirmed by oral endoscopic examination, was transected. After surgery, all foals had the epiglottis positioned normally, dorsal to the soft palate. Clinical signs of oronasal reflux resolved by the second nursing attempt in 3 foals, whereas this was difficult to assess in one foal that was nursed intermittently because of the mares behavior. This foal died 2 days later. The other 3 foals have had normal epiglottic function for 2-4 years. Persistent frenulum of the epiglottis should be considered in foals with oronasal reflux from birth. With appropriate medical and surgical management the prognosis for resolution should be good.

Gross placental morphology and foal serum biochemistry as predictors of foal health.

PubMed

Pirrone, A; Antonelli, C; Mariella, J; Castagnetti, C

2014-06-01

The aim of this study was to verify if changes in blood glucose, creatinine, urea, and fibrinogen concentrations evaluated at birth reflect gross placenta abnormalities, and are useful to identify foals that suffered from placental dysfunction. A total of 92 mares were included in the present study: 68 delivered healthy foals and they were included in group 1; 24 delivered sick foals and they were included in group 2. In group 2, foals' clinical diagnoses included perinatal asphyxia syndrome (PAS; n = 20) and prematurity and/or dysmaturity (n = 4). The proportion of sick foals was greater when placental abnormalities were observed (χ(2) [1, n = 89] = 5.00; P = 0.025). Serum creatinine concentration at birth was higher in sick than in healthy foals (P = 0.003), and blood glucose concentrations at birth was smaller in sick than in healthy foals (P = 0.007). No difference was found in blood chemistry results between survivors and nonsurvivors of group 2. Serum creatinine concentration was higher in foals born from grossly abnormal than in foals born from grossly normal placenta (P = 0.029), and it was higher in foals affected by PAS (311.17 μmol/L) than in healthy foals (238.24 μmol/L) (P = 0.004). In a clinical setting, serum creatinine and blood glucose concentrations should be evaluated at birth, particularly in foals born from grossly abnormal placenta. The association of clinical and laboratory data could be particularly important to promptly identify and treat foals with a higher risk to develop PAS. Copyright © 2014 Elsevier Inc. All rights reserved.

STS-86 Mission Specialist Wolf at SLF for TCDT

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf arrives in a T-38 jet at KSCs Shuttle Landing Facility for the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the mission, Wolf will transfer to the Mir 24 crew, replacing astronaut C. Michael Foale, who will return to Earth with the rest of the STS-86 crew. Wolf is scheduled to remain on the Mir until his replacement arrives on the STS-89 mission in January. STS-86 is targeted for a Sept. 25 launch aboard the Space Shuttle Atlantis.

Cryptosporidium parvum infection in a mare and her foal with foal heat diarrhoea.

PubMed

Perrucci, Stefania; Buggiani, Claudia; Sgorbini, Micaela; Cerchiai, Isabella; Otranto, Domenico; Traversa, Donato

2011-12-15

Cryptosporidium infection was molecularly investigated in mares and in their neonatal foals for which the occurrence of foal heat diarrhoea was also assessed. Thirty-seven mare/foal pairs were included in the study. All foals were born in the same stud farm during 2006-2008 breeding seasons. Two faecal samples, one prior to and one after delivery were collected from each mare, whereas three faecal samples were taken from each foal, i.e. at 8, 10 and 12 days of age. All samples (74 from mares and 111 from foals) were divided into two aliquots, one of which was examined for the presence of Cryptosporidium by a commercially available microplate ELISA kit, while the second aliquot of all ELISA-positive samples was molecularly examined. Nine out of 37 examined foals presented foal heat diarrhoea and one of them scored positive for Cryptosporidium, together with its mare. More specifically, four samples belonging to the same mare/foal pair resulted positive for Cryptosporidium upon both ELISA and PCR. The sequence analysis of the COWP gene showed the occurrence of the zoonotic species Cryptosporidium parvum. The possibility that foal heat diarrhoea-like episodes may be due to neonatal cryptosporidiosis and their relevance for the health of horses and of humans handling diarrhoeic neonatal foals and their mares are discussed. Copyright © 2011 Elsevier B.V. All rights reserved.

STS 51-L crewmembers during training session in flight deck simulation

NASA Technical Reports Server (NTRS)

1985-01-01

S85-46207 (December 1985) --- Shuttle Mission Simulator (SMS) scene of astronauts Michael J. Smith, Ellison S. Onizuka, Judith A. Resnik, and Francis R. (Dick) Scobee in their launch and entry positions on the flight deck. The photo was taken by Bill Bowers.

Foals raised on pasture with or without daily pyrantel tartrate feed additive: comparison of parasite burdens and host responses following experimental challenge with large and small strongyle larvae.

PubMed

Monahan, C M; Chapman, M R; Taylor, H W; French, D D; Klei, T R

1997-12-31

Three groups of foals were raised under different management programs in this study: Group 1 (n = 6) and Group 2 (n = 6) were raised with their dams on pasture; Group 3 foals (n = 5) were raised under parasite-free conditions. Mares and foals of Group 1 received daily pyrantel tartrate (PT) treatment with their pelleted feed ration, whereas mares and foals of Groups 2 and 3 received only the pelleted ration. Pasture-reared foals were weaned and moved to a heavily contaminated pasture for 5 weeks. Group 1 foals continued to receive daily PT treatment whereas Group 2 foals received only the pelleted feed ration. Following this period, all foals were moved into box stalls. Half of each group was challenged with 10(3) Strongylus vulgaris infective third-stage larvae (L3), 5 x 10(3) Strongylus edentatus L3 and 10(5) mixed cyathostome L3; the remaining half served as unchallenged controls. Necropsy examinations were performed 6-week post-challenge for evaluation of parasite burdens and lesions. Daily PT treatment of Group 1 reduced the patent cyathostome infections of both mares and foals and was effective in reducing pasture burdens of infective larvae. Daily treatment of Group 1 foals during weaning continued to suppress EPG levels; however, it did not prevent large strongyle infections during the weaning period. Group 1 foals were more sensitive to challenge than Group 2 foals, which did not exhibit any post-challenge disturbances. Group 1 foals were equally susceptible to challenge as parasite-free foals.

Endoscopic evaluation of changes in gastric lesions of Thoroughbred foals.

PubMed

Murray, M J; Grodinsky, C; Cowles, R R; Hawkins, W L; Forfa, R J; Luba, N K

1990-05-15

Gastroendoscopic examinations were conducted on thirty-two 2- to 60-day-old Thoroughbred foals on 5 breeding farms. Repeat gastroendoscopic examinations were performed 35 to 135 days after the initial examination, with the age of foals ranging from 39 to 190 days. On initial endoscopic examination, lesions consisting of ulcers and/or erosions were most prevalent in the stratified squamous epithelial mucosa adjacent to the margo plicatus along the greater curvature of the stomach (15 of 32 foals), and were observed much less frequently at other sites within the stomach. In addition to ulcers and erosions, squamous epithelial desquamation at the margo plicatus was observed in 16 of 19 foals less than 30 days old and in 3 of 13 foals 30 to 60 days old, and was not seen in any foal on repeat endoscopy. At the time of repeat endoscopic examination, the frequency of ulcers and erosions at the margo plicatus was significantly (P less than 0.01) less than at initial examination (4 of 32 foals vs 15 of 32 foals). Lesions had healed in 14 of the 15 foals with lesions at the margo plicatus on the initial examination. Lesions were observed in the glandular mucosa of the fundus in 3 of 32 foals on initial examination and in 6 of 32 foals reexamined. Lesions in the glandular fundus observed on initial examination had healed in 2 of 3 foals, and of the 6 foals with glandular mucosal lesions on reexamination, 5 had developed lesions since the initial examination.(ABSTRACT TRUNCATED AT 250 WORDS)

STS-86 crew members (Parazynski, Wolf, Lawrence) in slidewire basket

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialists Scott E. Parazynski, at left, David A. Wolf, and Wendy B. Lawrence, at right, participate in emergency egress training at Launch Pad 39A as part of Terminal Countdown Demonstration Test (TCDT) activities. They are the three U.S. astronauts who will serve as mission specialists during the planned 10-day flight to the Russian Space Station Mir. Also serving as mission specialists will be Vladimir Georgievich Titov of the Russian Space Agency and Jean-Loup J.M. Chretien of the French Space Agency, CNES. STS-86 will be the seventh docking of the Space Shuttle with the Mir. During the docking, Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25.

Time of foaling in Arabian mares raised in Tiaret, Algeria

PubMed Central

Meliani, Samia; Benallou, Bouabdellah; Halbouche, Miloud; Haddouche, Zohra

2013-01-01

Objective To enhance effectiveness of reproduction management in Arabian mares, factors influencing the time of foaling were investigated in this study. Methods Data were collected at the National Haras of Tiaret in Algeria from 2003 to 2010. The foaling time of 255 Arabian pure bred mares, aged from 3 to 20 years were used for this study. Results A total of 78.07% of foaling happens between 7 pm and 6 am. Conclusions The influence of the month of foaling and the sex of the foal, on the time of foaling was statically significant. PMID:23835758

Laterality of suckling behaviour in three zebra species.

PubMed

Pluháček, Jan; Olléová, Michaela; Bartošová, Jitka; Pluháčková, Jana; Bartoš, Luděk

2013-01-01

Although side preference while suckling is an easily characterised lateralised behaviour, few studies have been conducted. We observed laterality in suckling behaviour in three captive zebra species to test two hypotheses: laterality affected by the foal (motor laterality) and laterality affected by the mother. In total we observed 35 foals of Grevy's, plains, and mountain zebra in two zoos and recorded 5128 successful suckling bouts and 9095 unsuccessful suckling attempts. At the population level the only factor affecting side preference of suckling bouts and attempts was the identity of the individual foal. Ten foals showed individual preferences: seven foals preferred suckling from the left side of the mother, three preferred suckling from the right side of the mother. The individual preferences increased with increasing age of the foal. Only one foal was refused more often from the opposite side than the preferred side used for suckling whereas three other foals were refused from the preferred side. Foals that preferred suckling either from left or right side were refused by the mare more often than foals which showed non-preference. Thus lateral preferences in suckling behaviour of zebra foals seem to be in line with the motor laterality hypotheses.

Epidural migration of new methylene blue in 0.9% sodium chloride solution or 2% mepivacaine solution following injection into the first intercoccygeal space in foal cadavers and anesthetized foals undergoing laparoscopy.

PubMed

Lansdowne, Jennifer L; Kerr, Carolyn L; Bouré, Ludovic P; Pearce, Simon G

2005-08-01

To determine the relationship between epidural cranial migration and injectate volume of an isotonic solution containing dye in laterally recumbent foal cadavers and evaluate the cranial migration and dermatome analgesia of an epidural dye solution during conditions of laparoscopy in foals. 19 foal cadavers and 8 pony foals. Foal cadavers received an epidural injection of dye solution (0.05, 0.1, 0.15, or 0.2 mL/kg) containing 1.2 mg of new methylene blue (NMB)/mL of saline (0.9% NaCl) solution. Length of the dye column and number of intervertebral spaces cranial and caudal to the injection site were measured. Anesthetized foals received an epidural injection of dye solution (0.2 mL/kg) containing saline solution or 2% mepivacaine. Foals were placed in a 100 head-down position, and pneumoperitoneum was induced. Dermatome analgesia was determined by use of a described electrical stimulus technique. Foals were euthanatized, and length of the dye column was measured. Epidural cranial migration of dye solution in foal cadavers increased with increasing volume injected. No significant difference was found in epidural cranial migration of a dye solution (0.2 mL/kg) between anesthetized foals undergoing conditions of laparoscopy and foal cadavers in lateral recumbency. Further craniad migration of the dye column occurred than indicated by dermatome analgesia. Epidural cranial migration increases with volume of injectate. On the basis of dermatome analgesia, an epidural injection of 2% mepivacaine (0.2 mL/kg) alone provides analgesia up to at least the caudal thoracic dermatome and could permit caudal laparoscopic surgical procedures in foals.

Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate.

PubMed

Slocombe, J Owen D; de Gannes, Rolph V G; Lake, Mary C

2007-04-30

The aims of studies in 2002 and 2003 on three farms with 76 foals naturally infected with Parascaris equorum were to (i) identify if the nematode was resistant to ivermectin and moxidectin, and (ii) confirm the effectiveness of fenbendazole and pyrantel pamoate for the parasite. Twelve clinical trials, each with a Fecal Egg Count Reduction Test, were conducted on two Thoroughbred and one Standardbred farms in southwestern Ontario, Canada. In each trial, Parascaris eggs/g feces were estimated for each foal pre- and post-treatment using the Cornell-Wisconsin double flotation and Cornell-McMaster dilution techniques. On each farm and for each trial, foals were randomized into treatment groups. Treatments were ivermectin, moxidectin, fenbendazole, pyrantel pamoate administered at the manufacturers' recommended dosages, and some foals were untreated. The overall efficacy for ivermectin was 33.5% (19 foals) and for moxidectin 47.2% (28 foals). Fenbendazole (16 foals) and pyrantel pamoate (21 foals) were highly effective for P. equorum each at 97.6%. For fenbendazole, 15 foals had 100% and for pyrantel pamoate 17 foals had >97% with 14 at 100%.

Immune responses of pony foals during repeated infections of Strongylus vulgaris and regular ivermectin treatments.

PubMed

Dennis, V A; Klei, T R; Miller, M A; Chapman, M R; McClure, J R

1992-04-01

Ten helminth-free pony foals divided into three groups were used in this study. Eight foals were each experimentally infected per os with 50 Strongylus vulgaris infective larvae weekly for 4 weeks, at which time one foal died of acute verminous arteritis. The remaining seven foals subsequently received 50 S. vulgaris infective larvae every 2 weeks for an additional 20 weeks. Four of the infected foals remained untreated (Group 1) and three of the infected foals were given ivermectin at 8, 16 and 24 weeks post initial infection (Group 2). Two foals served as controls (Group 3). Foals in Group 1 developed eosinophilia, which was sustained throughout the course of infection. A mild eosinophilia also developed in Group 2 foals; however, the eosinophil numbers were markedly reduced for 3 weeks after each ivermectin treatment. Only foals in Group 1 developed significant (P less than 0.05) hyperproteinemia, hyperbetaglobulinemia and a reversal of the albumin/globulin (A/G) ratio 4 weeks after initial infection. Significant (P less than 0.05) IgG anti-S. vulgaris ELISA titers developed in foals in Groups 1 and 2 3 weeks after infection and were sustained for the duration of the experiment. Western blot analysis of soluble somatic antigens of S. vulgaris adult female and male worms probed with sera from foals in Groups 1 and 2 revealed only subtle differences between these animals. The blastogenic reactivity of peripheral blood mononuclear cells (PBMC) to phytohemagglutinin and concanavalin A was not significantly different between groups. Peripheral blood mononuclear cells from foals in Groups 1 and 2 developed significant (P less than 0.05) blastogenic reactivity to S. vulgaris soluble adult somatic antigen when examined at 25 weeks after infection. Mesenteric lymph node cells from foals in Group 2, although not statistically significant, were more reactive to antigen than were the mesenteric lymph node cells from foals in Group 1 when examined at 27 weeks after infection. These results suggest that significant alterations in the immune response of ponies to S. vulgaris does not occur after intravascular killing of larvae by ivermectin treatments.

Parturition, dystocia and foal survival: a retrospective study of 1047 births.

PubMed

McCue, P M; Ferris, R A

2012-02-01

An understanding of the normal events of foaling, causes of dystocia and clinical outcomes is important for equine practitioners. The goals of the present study were to: 1) evaluate factors that influence gestation length; 2) report duration of Stage II labour; 3) determine the frequency of dystocia and premature placental separation; and 4) determine the relationship between problems at foaling and foal survival. Foaling records of 1047 mare births were evaluated. The average gestation length was 342.7 days [corrected] +/- 0.4 days, with no effect of mare age or breed observed. Mares carrying male fetuses had a longer gestation (P < or = 0.001) than mares carrying female fetuses. A majority (52.8%) of mares foaled at night between 2000 h and 0200 h when the facility was quiet. Dystocia occurred in 10.1% of all births and the incidence rate was higher in Thoroughbred mares than in Quarter Horse mares. The most common cause of dystocia was abnormalities of fetal posture. A delay in foal delivery beyond 40 min of Stage II of labour was associated with a significant increase in foal mortality. In addition, an increase in foal morbidity and mortality was noted when the interval from birth to standing or birth to nursing was prolonged. Early detection and rapid appropriate intervention are critical to foal survival in an equine dystocia. Equine veterinarians should counsel horse owners that early recognition of a foaling problem and rapid, appropriate intervention are critical to the survival of a foal.

Effect of protein source in liquid formula diets on food intake, physiologic values, and growth of equine neonates.

PubMed

Buffington, C A; Knight, D A; Kohn, C W; Madigan, J E; Scaman, P A

1992-10-01

The effects of 2 liquid formula diets differing in protein source were evaluated in orphan foals. The response of 7 foals fed a diet containing casein as the protein source, and 6 foals fed a diet containing a combination of whey and casein, was compared with the response in a reference group of 8 mare-raised foals. Orphaned foals were fed 150 kcal/kg of body weight/d, divided into 6 equal feedings of 25 kcal/kg. Formula intake was comparable among the experimental groups, and foals fed the liquid formula diet grew as well as mare-raised foals. There was no difference among groups in mean daily body weight gain, wither height, heart girth, body temperature, pulse, respiration rate, capillary refill time, or skin tenting. Insulin and blood glucose concentrations increased in both groups of foals fed formula diets, returning to prefeeding values within 4 hours. Differences among groups were found for serum alkaline phosphatase, alanine transaminase, cholesterol, creatinine, and glucose values; all other serum chemical values were comparable among groups. Plasma amino acid determinations revealed that arginine and ornithine were significantly lower in foals in both experimental groups than in reference foals, suggesting that arginine may have been the limiting amino acid in these diets. Diarrhea developed in foals in all treatment groups, but in most cases was self-limiting. These results suggest that the protein source of liquid formula diets may be less important in foals than in infants.

Botulism in foals less than 6 months of age: 30 cases (1989-2002).

PubMed

Wilkins, Pamela A; Palmer, Jonathan E

2003-01-01

Botulism has been recognized as a clinical entity in foals since the 1960s. Also known as "Shaker foal" disease, the toxicoinfectious form of botulism affects foals, with the highest incidence in the United States seen in Kentucky and the mid-Atlantic region. The disease is characterized by progressive muscular weakness caused by the action of botulism neurotoxin at cholinergic neuromuscular junctions. Increased number of episodes and duration of recumbency, muscular trembling, and dysphagia are seen in affected foals. Left untreated, the disease can be rapidly fatal, with death occuring secondary to respiratory muscle paralysis within 24 to 72 hours of the onset of clinical signs. Very mildly affected foals can survive with minimal treatment Despite advances made in treatment of these foals, including administration of botulism antitoxin early in the course of the disease, there is still an impression that the disease carries a high mortality rate. The purpose of this study was to evaluate outcome in 30 foals <6 months of age diagnosed with botulism between 1989 and 2002 at the George D. Widener Large Animal Hospital, New Bolton Center. Two foals were euthanized for economic reasons early in the disease course, and I died while being treated. Survival of treated cases was greater than 96%. Approximately 50% of the cases required oxygen therapy, whereas 30% required mechanical ventilation. All foals, excepting 1 mildly affected foal, received botulism antitoxin. Mean duration of hospitalization was 14 days. With appropriate treatment, foals with botulism have a high survival rate.

International Space Station (ISS)

NASA Image and Video Library

2001-12-01

This is the official STS-110 crew portrait. In front, from the left, are astronauts Stephen N. Frick, pilot; Ellen Ochoa, flight engineer; and Michael J. Bloomfield, mission commander; In the back, from left, are astronauts Steven L. Smith, Rex J. Walheim, Jerry L. Ross and Lee M.E. Morin, all mission specialists. Launched aboard the Space Shuttle Orbiter Atlantis on April 8, 2002, the STS-110 mission crew prepared the International Space Station (ISS) for future space walks by installing and outfitting a 43-foot-long Starboard side S0 truss and preparing the Mobile Transporter. The mission served as the 8th ISS assembly flight.

Total plasma magnesium in healthy and critically ill foals.

PubMed

Mariella, J; Isani, G; Andreani, G; Freccero, F; Carpenè, E; Castagnetti, C

2016-01-15

Abnormalities in total Mg (tMg) concentration in plasma and/or serum are common in critically ill humans, and the association with increased mortality has been documented in several clinical studies in adults and newborns with hypoxic-ischemic encephalopathy. Abnormalities in tMg were studied in hospitalized dogs, cats, and adult horses. Newborn foals were scarcely studied with regard to Mg concentration. The aims of the present study were: (1) to compare two analytical methods for the determination of tMg in plasma: the automated colorimetric method and the atomic absorption spectrometry; (2) to measure plasma tMg in healthy foals during the first 72 hours after birth and in sick foals during the first 72 hours of hospitalization; (3) to compare total plasma Mg concentration among healthy foals, foals affected by perinatal asphyxia syndrome (PAS), prematurity and/or dismaturity, and sepsis; (4) to evaluate tMg plasma concentration in surviving and non-surviving foals. One hundred seventeen foals were included in the study: 20 healthy and 97 sick foals. The automated method used in clinical practice probably overestimates plasma tMg. Due to its higher sensitivity and specificity, the atomic absorption spectrometry should be considered the method of choice from an analytical point of view, but requires an instrumentation not easily available in any laboratory and specific technical skills and competencies. Plasma tMg in healthy foals were included in the range 0.52 to 1.01 mmol/L and did not show any time-dependent change during the first 72 hours of life. In sick foals, tMg evaluated at T0 was statistically higher than tMg measured at subsequent times. Foals affected by PAS had a tMg at T0 significantly higher (P < 0.01) than healthy, septic, and premature and/or dysmature foals. The t test found significantly higher (P < 0.01) plasma tMg measured at T0 in non-surviving than in surviving foals. Plasma tMg could be a useful parameter for the diagnosis of PAS and the formulation of the prognosis in critically ill foals. Copyright © 2016 Elsevier Inc. All rights reserved.

Thyroid hormone concentrations in foals affected by perinatal asphyxia syndrome.

PubMed

Pirrone, Alessandro; Panzani, Sara; Govoni, Nadia; Castagnetti, Carolina; Veronesi, Maria Cristina

2013-10-01

The hypothalamus-pituitary-thyroid axis has specific functions, mostly related to metabolic activities, cell differentiation, and development. To the authors' knowledge, there are no studies about thyroid hormone (TH) concentrations in foals affected by perinatal asphyxia syndrome (PAS). Hence, the aims of the study are (1) to evaluate plasma TH concentrations (T3 and T4) in healthy foals during the first 7 days of life; (2) to evaluate plasma TH concentration (T3 and T4) in critically ill foals affected by PAS during the first 7 days of hospitalization; and (3) to compare TH concentrations between surviving and nonsurviving critically ill foals. Forty-five Standardbred foals were enrolled in this prospective observational study: 21 healthy foals (group 1) and 24 foals affected by PAS (group 2). Jugular blood samples were collected within 10 minutes from birth/admission and every 24 hours for 7 days (t0-t7). TH concentrations were analyzed by RIA. In both groups, T3 concentration was significantly lower at t4, t5, t6, and t7 compared with t1 (P < 0.05), and T4 concentration was significantly higher at birth than at all other time points (P < 0.01). No differences were found in TH concentrations at admission between surviving (n = 20) and nonsurviving (n = 4) foals. Statistical comparison between healthy and PAS foals divided into age groups showed significantly lower TH concentrations at t0 in PAS foals <12 hours old at admission (P < 0.01). In conclusion, PAS may cause lower T3 and T4 concentrations in affected foals than in age-matched healthy foals, as reported for other systemic illnesses, such as sepsis and prematurity. TH concentrations showed no prognostic value, which maybe due to the small number of nonsurviving foals in this study. Further studies are needed to find out if thyroid replacement therapy could be useful in the treatment of critically ill foals affected by PAS. Copyright © 2013 Elsevier Inc. All rights reserved.

STS-103 Discovery reaches to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

Space Shuttle Discovery approaches Launch Pad 39B where the orbiter, external tank and solid rocket boosters will undergo final preparations for the STS-103 launch. The mission is a 'call-up' due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, both with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

STS-99 Endeavour rolls out to Launch Pad 39A

NASA Technical Reports Server (NTRS)

1999-01-01

Framed by branches of oak leaves in this photo, Space Shuttle Endeavour, on its mobile launcher platform, is transferred to Launch Pad 39B via the crawler-transporter. The van behind it is barely noticeable next to the gigantic stature of the moving vehicle. Launch of STS-103 is targeted for Dec. 16 at 9:18 p.m. EST. The crew, comprising Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, with the European Space Agency (ESA), and Jean-Frangois Clervoy of France, also with ESA, will be servicing the Hubble Space Telescope, replacing gyros, insulation and equipment in up to three space walks. Landing is targeted for Dec. 26 about 6:56 p.m. at KSC's Shuttle Landing Facility.

Launch of STS-63 Discovery

NASA Image and Video Library

1995-02-03

STS063-S-003 (3 Feb. 1995) --- A 35mm camera was used to expose this image of the space shuttle Discovery as it began its race to catch up with the Russia's Mir Space Station. Liftoff from Launch Pad 39B, Kennedy Space Center (KSC) occurred at 12:22:04 (EST), Feb. 3, 1995. Discovery is the first in the current fleet of four space shuttle vehicles to make 20 launches. Onboard for the 67th (STS-63 is out of sequence) shuttle flight are astronauts James D. Wetherbee, commander; Eileen M. Collins, pilot; Bernard A. Harris Jr., payload commander; and mission specialists Janice Voss and C. Michael Foale; along with Russian cosmonaut Vladimir G. Titov. Photo credit: NASA

KSC-06pd0216

NASA Image and Video Library

2006-02-07

KENNEDY SPACE CENTER, FLA. - As a rosy dawn creeps over the horizon, Deputy Associate Administrator for Exploration Operations Michael Foale (left) and astronaut Bill Readdy (center) talk to Steve Fossett about the anticipated flight of the Virgin Atlantic GlobalFlyer. Fossett will pilot the GlobalFlyer on a record-breaking attempt by flying solo, non-stop without refueling, to surpass the current record for the longest flight of any aircraft. Fossett is expected to take off from the KSC SLF. Later, takeoff of the GlobalFlyer was postponed due to a fuel leak that appeared during the last moments of loading. The next planned takeoff attempt is 7 a.m. Feb. 8 from the SLF. Photo credit: NASA/Kim Shiflett

STS-103 Payload Commander Smith and his wife DEPART PAFB for Houston

NASA Technical Reports Server (NTRS)

1999-01-01

STS-103 Payload Commander Steven L. Smith and his wife, Peggy, smile for the camera on the runway at Patrick Air Force Base in Cocoa Beach, Fla. The STS-103 crew and their families are preparing to board an airplane that will return them to their home base at the Johnson Space Center in Houston following the successful completion of their mission. Discovery landed in darkness the previous evening, Dec. 27, on runway 33 at KSC's Shuttle Landing Facility at 7:00:47 p.m. EST. This was the first time that a Shuttle crew spent the Christmas holiday in space. The other STS-103 crew members are Commander Curtis L. Brown Jr.; Pilot Scott J. Kelly; and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France. The STS-103 mission accomplished outfitting the Hubble Space Telescope with six new gyroscopes, six new voltage/temperature improvement kits, a new onboard computer, a new solid state recorder and new data transmitter, a new fine guidance sensor along with new insulation on parts of the orbiting telescope. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery.

STS-103 Pilot Kelly and MS Clervoy and Smith DEPART PAFB for Houston

NASA Technical Reports Server (NTRS)

1999-01-01

STS-103 Pilot Scott J. Kelly holds his daughter as he talks to Mission Specialists and fellow crew members Jean-Frangois Clervoy of France and Steven L. Smith on the runway at Patrick Air Force Base in Cocoa Beach, Fla. The STS-103 crew and their families are preparing to board an airplane that will return them to their home base at the Johnson Space Center in Houston following the successful completion of their mission. Discovery landed in darkness the previous evening, Dec. 27, on runway 33 at KSC's Shuttle Landing Facility at 7:00:47 p.m. EST. This was the first time that a Shuttle crew spent the Christmas holiday in space. The other STS-103 crew members are Commander Curtis L. Brown Jr. and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland. The STS-103 mission accomplished outfitting the Hubble Space Telescope with six new gyroscopes, six new voltage/temperature improvement kits, a new onboard computer, a new solid state recorder and new data transmitter, a new fine guidance sensor along with new insulation on parts of the orbiting telescope. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery.

Occurrence of bacteria and polymorphonuclear leukocytes in fetal compartments at parturition; relationships with foal and mare health in the peripartum period.

PubMed

Hemberg, E; Einarsson, S; Kútvölgyi, G; Lundeheim, N; Bagge, E; Båverud, V; Jones, B; Morrell, J M

2015-07-01

This study investigated the relationship of the health of the newborn foal and (1) number of polymorphonuclear leukocytes (PMNLs) in the amniotic fluid, (2) bacteria present in the amniotic fluid and the venous umbilical blood, and (3) bacteria present in the uterus of the newly foaled mare. A further aim was to investigate relationships between the bacteriologic findings in the amniotic fluid, umbilical blood, and uterus postpartum. Samples were taken from 50 Standardbred trotter foaling mares from a well-managed stud in Sweden. Parturition was spontaneous in all cases. Length of pregnancy, parturition and postpartum complications, health status of the foal, the time between foaling and the expulsion of the placenta, and the number of postfoaling mares becoming pregnant after insemination were recorded. Amniotic fluid was collected when the amniotic vesicle was clearly visible; it was analyzed for bacteriology and occurrence of PMNLs. Umbilical blood was analyzed for the presence of bacteria and the concentration of serum amyloid A. The uterus of the mare was swabbed for bacteriology 6 to 17 hours postpartum. A blood sample was taken from the foal before administering plasma. The foals were divided into two groups: group 1 required up to 2 hours to rise after birth (≤2 hours; 31 foals) and group 2 required more than two hours (>2 hours; 19 foals). The length of gestation varied between 332 and 356 days; there was no significant difference in gestation length between the two foal groups. Partus and postpartum complications occurred in a significantly higher proportion of mares giving birth to group 2 foals than group 1 foals (P = 0.02), although uterine culture postpartum and the subsequent pregnancy rate per season were not different between the groups. Compromised health status was significantly higher among foals belonging to group 2 than group 1 (P = 0.001). Most of the amniotic samples contained 5% or less PMNLs. Only three samples contained more than 30% PMNLs; group 2 foals had the highest percentage of PMNLs. Bacterial growth was found in both amniotic fluid (57%) and umbilical blood (35%) in mares irrespective of whether their foals were healthy or compromised. Coagulase-negative staphylococci were the most frequent bacteria. There were no differences in bacterial occurrence in amniotic fluid or in umbilical blood between the two foal groups. Copyright © 2015 Elsevier Inc. All rights reserved.

A preliminary study of the tolerance of healthy foals to a low residue enteral feeding solution.

PubMed

Kohn, C W; Knight, D A; Yvorchyk-St Jean, K E; Scaman, P A; Ruey, P R

1991-09-01

After a three day acclimatization period, six healthy, young (aged 4 to 20 days) orphan foals of mixed breeding were fed 100 per cent of their caloric needs (estimated at 523 kjoules/kg bodyweight [bwt] or 125 kcal/kg bwt/day) as a low residue isotonic feeding solution (LRF) for seven days. The solution provided 4.18 kjoules (1 kcal/ml) and was fortified with minerals and protein to meet estimated foal requirements. The solution was fed through an indwelling 12 French feeding tube. Five of the six foals completed the study; the loss of the sixth foal apparently was unrelated to the feeding protocol. The foals tolerated LRF well. Signs of intolerance were noted in two foals and were limited to flatulence, mild bloat and very mild abdominal pain associated with a decreased interval between two feedings during the first 48 h on 100 per cent LRF. Complete recovery without therapy occurred within 6 h and feedings were resumed. Growth in height and weight were comparable to published data for healthy foals raised with their dams. Feeding tubes were easily maintained with no apparent dysphagia, regurgitation or discomfort to foals. This low residue, calorically dense, isotonic feeding solution may be useful for enteral feeding of selected foals aged at least seven days.

Severe hyponatraemia in foals: clinical findings, primary diagnosis and outcome.

PubMed

Collins, N M; Axon, J E; Carrick, J B; Russell, C M; Palmer, J E

2016-06-01

To evaluate severe hyponatraemia in foals presenting as medical emergencies to an intensive care unit (ICU) in order to determine the prevalence, clinical findings, primary diagnosis and outcome. Retrospective case study of records from Thoroughbred foals aged less than 3 months presenting to an ICU as medical emergencies in 2002-12; foals with severe hyponatraemia (serum sodium <122 mmol/L) on admission laboratory data were identified. Data retrieved included signalment, clinical findings, laboratory results, primary diagnosis, treatment and outcome. Severe hyponatraemia was identified in 69/1718 Thoroughbred foals (4%) presenting to the ICU during the study period. Of the 69 foals, 11 (15.9%) presented with neurological signs attributable to hyponatraemic encephalopathy and 7 of these foals had seizures; other neurological signs included obtundation, ataxia and apparent blindness. The three most common primary diagnoses of the 69 foals with severe hyponatraemia were renal disease (18/69, 26.1%), enterocolitis (16/69, 23.2%) and uroperitoneum (15/69, 21.7%). Treatment was directed at the primary disease and correction of the hyponatraemia. A total of 50 of the 69 foals (72.5%) with severe hyponatraemia survived to hospital discharge and 38 of them (76%) survived at least 12 months following discharge. The prevalence of severe hyponatraemia in this study population was 4%. The majority of foals with severe hyponatraemia did not demonstrate direct clinical manifestations as a result of the low serum sodium concentration. The outcome of foals with severe hyponatraemia was mostly favourable. © 2016 Australian Veterinary Association.

STS-103 crew wait inside Discovery for simulated countdown exercise

NASA Technical Reports Server (NTRS)

1999-01-01

Strapped into their seats inside the orbiter Discovery for a simulated countdown exercise are (left to right) STS-103 Mission Specialists Claude Nicollier of Switzerland, Steven L. Smith, and C. Michael Foale (Ph.D.). The simulation is part of Terminal Countdown Demonstration Test (TCDT) activities. The TCDT also provides the crew with emergency egress training and opportunities to inspect their mission payload in the orbiter's payload bay. Other crew members taking part in the TCDT are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Jean-Fran'''ois Clervoy of France. Clervoy and Nicollier are with the European Space Agency. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

Resuscitation and emergency management for neonatal foals.

PubMed

Corley, Kevin T T; Axon, Jane E

2005-08-01

Early intervention can dramatically alter outcome in foals. Cardio-pulmonary cerebral resuscitation can be successful and clinically worthwhile when applied to foals that arrest as part of the birthing process. Readily available equipment and an ordered plan starting with addressing the respiratory system (airway and breathing) followed by the circulatory system (circulation and drugs) are the keys to success. Hypoglycemia is common in foals that are not nursing and in septic foals. Support of serum glucose can be an important emergency treatment. Respiratory support with oxygen therapy should be considered in all foals following resuscitation and dystocia. Other foals that are likely to benefit from oxygen are those that are dyspneic, cyanotic, meconium-stained after birth,or recumbent. Emergency therapies, applied correctly, are expected to result in decreased mortality and morbidity.

Artificial suckling in Martina Franca donkey foals: effect on in vivo performances and carcass composition.

PubMed

De Palo, Pasquale; Maggiolino, Aristide; Milella, Paola; Centoducati, Nicola; Papaleo, Alessandro; Tateo, Alessandra

2016-01-01

In recent years, there has been an increasing interest on donkey milk production, on its characteristics, and also on breeding techniques. Donkey milk is characterized by high economic value, although the productive level of jennies is poor. During the milking process, foals are usually separated from their dams, allowing the milk collection in the mammary gland of jennies before milking session. This takes 8 h per day of fastening period for lactating donkey foals. During this period, it could be possible to apply a partial artificial suckling system (artificial suckling during daytime and natural suckling during the night). The aim of the work is the evaluation of the effect of this innovative technique on in vivo performances and on meat production traits of Martina Franca donkey foals. Forty Martina Franca jennies with their foals were used for the trial. After colostrum assumption, 20 foals were partially artificially suckled (AS) during each day, and 20 foals were naturally suckled (NS). From 8.00 to 20.00, both groups were separated from their mothers in order to allow the milking procedures of the jennies. The AS group was in a stall equipped with an automatic calf-suckling machine. For each group, 10 foals were slaughtered at 12 months and 10 foals at 18 months. Artificial suckling system positively affected the growth rate of donkey foals, particularly in the first 6 months from birth, with higher weekly weight gain (P < 0.01), higher final live weight (P < 0.001), and carcass weight (P < 0.01), but no effects were observed on carcass dressing percentage (P > 0.05). Artificial suckling system permitted to extend the time of foal separation from their mothers increasing milk collection time per day, awarding fastening periods in foals.

Use of Serial Quantitative PCR of the vapA Gene of Rhodococcus equi in Feces for Early Detection of R. equi Pneumonia in Foals.

PubMed

Madrigal, R G; Shaw, S D; Witkowski, L A; Sisson, B E; Blodgett, G P; Chaffin, M K; Cohen, N D

2016-01-01

Current screening tests for Rhodococcus equi pneumonia in foals lack adequate accuracy for clinical use. Real-time, quantitative PCR (qPCR) for virulent R. equi in feces has not been systematically evaluated as a screening test. The objective of this study was to evaluate the accuracy of qPCR for vapA in serially collected fecal samples as a screening test for R. equi pneumonia in foals. One hundred and twenty-five foals born in 2011 at a ranch in Texas. Fecal samples were collected concurrently with thoracic ultrasonography (TUS) screening examinations at ages 3, 5, and 7 weeks. Affected (pneumonic) foals (n = 25) were matched by age and date-of-birth to unaffected (n = 25) and subclinical (ie, having thoracic TUS lesions but no clinical signs of pneumonia) foals (n = 75). DNA was extracted from feces using commercial kits and concentration of virulent R. equi in feces was determined by qPCR. Subsequently affected foals had significantly greater concentrations of vapA in feces than foals that did not develop pneumonia (unaffected and subclinical foals) at 5 and 7 weeks of age. Accuracy of fecal qPCR, however, was poor as a screening test to differentiate foals that would develop clinical signs of pneumonia from those that would remain free of clinical signs (including foals with subclinical pulmonary lesions attributed to R. equi) using receiver operating characteristic (ROC) methods. In the population studied, serial qPCR on feces lacked adequate accuracy as a screening test for clinical R. equi foal pneumonia. Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Serum antibodies in mares and foals to Actinobacillus equuli whole cells, outer membrane proteins, and Aqx toxin.

PubMed

Holyoak, G R; Smith, C M; Boyette, R; Montelongo, M; Wray, J H; Ayalew, S; Duggan, V E; Confer, A W

2007-08-15

Actinobacillus equuli is carried in the alimentary tract of mares and can cause severe septicemia of neonatal foals. A hemolytic subspecies, A. equuli subsp. haemolyticus, and a non-hemolytic subspecies, A. equuli subsp. equuli, have been identified. Hemolytic strains produce the RTX toxin Aqx. The purpose of this study was to demonstrate sequentially in two sets of mare-foal pairs antibodies to A. equuli whole bacterial cells, outer membrane proteins, and recombinant Aqx and to compare the transfer of antibodies to these antigens between mares and their foals. Two mare/foal sets of sera were evaluated. Cohort A consisted of 18 mare-foal pairs obtained in the spring of 2005. Cohort B consisted of 10 mare-foal pairs obtained in the spring of 2006. For both sets, mare and foal sera were obtained immediately after foaling and prior to nursing (time 0) as well as at 12 and 24h and daily thereafter for 7 days. For Cohort B, sera were also obtained 30 days after birth. At parturition all mares had detectable antibodies to A. equuli whole cells and outer membranes; however, of those mares, two in Cohort A had undetectable antibodies to Aqx and their foals likewise had undetectable anti-Aqx antibodies. Antibodies against whole cells, outer membrane proteins, and Aqx were readily transferred from mares to foals. In most cases, there were significant correlations (p<0.05) between antibodies against whole cells, outer membrane proteins, and Aqx in mares' sera at the time of parturition and foal sera 24 after birth. Antibodies against the three antigen preparations had declined insignificantly (p>0.05) by day 30.

Qualitative and quantitative interpretation of computed tomography of the lungs in healthy neonatal foals.

PubMed

Lascola, Kara M; O'Brien, Robert T; Wilkins, Pamela A; Clark-Price, Stuart C; Hartman, Susan K; Mitchell, Mark A

2013-09-01

To qualitatively describe lung CT images obtained from sedated healthy equine neonates (≤ 14 days of age), use quantitative analysis of CT images to characterize attenuation and distribution of gas and tissue volumes within the lungs, and identify differences between lung characteristics of foals ≤ 7 days of age and foals > 7 days of age. 10 Standardbred foals between 2.5 and 13 days of age. Foals were sedated with butorphanol, midazolam, and propofol and positioned in sternal recumbency for thoracic CT. Image analysis software was used to exclude lung from nonlung structures. Lung attenuation was measured in Hounsfield units (HU) for analysis of whole lung and regional changes in attenuation and lung gas and tissue components. Degree of lung attenuation was classified as follows: hyperinflated or emphysema, -1,000 to -901 HU; well aerated, -900 to -501 HU; poorly aerated, -500 to -101 HU; and nonaerated, > -100 HU. Qualitative evidence of an increase in lung attenuation and patchy alveolar patterns in the ventral lung region were more pronounced in foals ≤ 7 days of age than in older foals. Quantitative analysis revealed that mean ± SD lung attenuation was greater in foals ≤ 7 days of age (-442 ± 28 HU) than in foals > 7 days of age (-521 ± 24 HU). Lung aeration and gas volumes were lower than in other regions ventrally and in the mid lung region caudal to the heart. CONCLUSIONS AND CLINICAL RELEVANCE-Identified radiographic patterns and changes in attenuation were most consistent with atelectasis and appeared more severe in foals ≤ 7 days of age than in older neonatal foals. Recognition of these changes may have implications for accurate CT interpretation in sedated neonatal foals with pulmonary disease.

Identification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in Thoroughbred foals.

PubMed

Jenvey, C; Caraguel, C; Howarth, G B; Riley, C B

2012-12-01

Prior to the start of endogenous production of immunoglobulins (Igs), absorption of maternal Igs is important to protect against pathogens in the early neonatal period. It is possible that mare- or foal-associated factors may influence neonatal IgA concentrations. The temporal relationships among serum and milk IgA concentrations in Thoroughbred mare-foal pairs were explored to determine if periparturient mare- and foal-associated factors contribute to the prediction of foal serum IgA concentrations. Blood and milk samples as well as complete veterinary records, were collected for 84 Thoroughbred mare-foal pairs from one month before to 2 months after parturition. Samples were tested using enzyme-linked immunosorbent assay (ELISA) for concentrations of IgA. Pairwise correlation coefficients were estimated (P < 0.01) and simple linear regression used to investigate unconditional associations between mare IgA levels, mare and foal risk factors and foal serum IgA concentration at 12 h. Backwards, stepwise elimination of nonsignificant factors was used to create a final model. There were significant temporal relationships among mare serum IgA and among colostrum and milk IgA concentrations within mares (P < 0.01). Mare serum IgA concentrations up to one month before parturition were associated with foal serum IgA concentrations at all time points and with colostrum and milk IgA concentrations. Mare serum IgA at -28 days and parity were associated with foal serum IgA concentration at 12 h (P < 0.001). Mare serum IgA concentrations up to 28 days before parturition, together with mare parity, are indicative of neonatal foal serum IgA concentrations. Mare serum and colostrum IgA concentrations may be useful peripartum predictors of neonatal mucosal immune status, enabling earlier intervention to prevent the consequences of mucosal infections.

Prevalence and characteristics of foal rejection in Arabian mares.

PubMed

Juarbe-Díaz, S V; Houpt, K A; Kusunose, R

1998-09-01

Separate surveys of Thoroughbred, Paint, and Arabian mare owners revealed a higher than expected rate of foal rejection in Arabian mares. A behavioural history form was submitted by owners of foal rejecting and nonrejecting Arabian mares, and maternal behaviour and management practices compared. Four generation pedigrees of rejecting and nonrejecting Arabian mares were also examined. Foal rejecting mares were more likely to avoid, threaten, squeal at, chase, bite, and kick their foals post partum than nonrejecting mares. Nonrejecting mares were more likely to lick, nicker and defend their foals post partum than rejecting mares. No statistically significant relationship was found between foal rejection and the type of breeding method (natural vs. artificial insemination), the presence of people at birth, the presence of nearby horses at birth, or assistance of the first nursing bout. The presence at least once of 1 of 2 related sires was statistically higher in the pedigrees of rejecting vs. nonrejecting mares. Inherited and learned or environmental factors are likely to affect the expression of foal rejection behaviour.

Concentrations of amino acids in the plasma of neonatal foals with septicemia.

PubMed

Zicker, S C; Spensley, M S; Rogers, Q R; Willits, N H

1991-07-01

Concentrations of amino acids in the plasma of 13 neonatal foals with septicemia were compared with the concentrations of amino acids in the plasma of 13 age-matched neonatal foals without septicemia. Analysis of the results revealed significantly lower concentrations of arginine, citrulline, isoleucine, proline, threonine, and valine in the plasma of foals with septicemia. The ratio of the plasma concentrations of the branched chain amino acids (isoleucine, leucine, and valine) to the aromatic amino acids (phenylalanine and tyrosine), was also significantly lower in the foals with septicemia. In addition, the concentrations of alanine, glycine, and phenylalanine were significantly higher in the plasma of foals with septicemia. Therefore, neonatal foals with septicemia had significant differences in the concentrations of several amino acids in their plasma, compared with concentrations from healthy foals. These differences were compatible with protein calorie inadequacy and may be related to an alteration in the intake, production, use, or clearance of amino acids from the plasma pool in sepsis.

Oral Administration of Electron-Beam Inactivated Rhodococcus equi Failed to Protect Foals against Intrabronchial Infection with Live, Virulent R. equi

PubMed Central

Rocha, Joana N.; Cohen, Noah D.; Bordin, Angela I.; Brake, Courtney N.; Giguère, Steeve; Coleman, Michelle C.; Alaniz, Robert C.; Lawhon, Sara D.; Mwangi, Waithaka; Pillai, Suresh D.

2016-01-01

There is currently no licensed vaccine that protects foals against Rhodococcus equi–induced pneumonia. Oral administration of live, virulent R. equi to neonatal foals has been demonstrated to protect against subsequent intrabronchial challenge with virulent R. equi. Electron beam (eBeam)-inactivated R. equi are structurally intact and have been demonstrated to be immunogenic when administered orally to neonatal foals. Thus, we investigated whether eBeam inactivated R. equi could protect foals against developing pneumonia after experimental infection with live, virulent R. equi. Foals (n = 8) were vaccinated by gavaging with eBeam-inactivated R. equi at ages 2, 7, and 14 days, or gavaged with equal volume of saline solution (n = 4), and subsequently infected intrabronchially with live, virulent R. equi at age 21 days. The proportion of vaccinated foals that developed pneumonia following challenge was similar among the vaccinated (7/8; 88%) and unvaccinated foals (3/4; 75%). This vaccination regimen did not appear to be strongly immunogenic in foals. Alternative dosing regimens or routes of administration need further investigation and may prove to be immunogenic and protective. PMID:26828865

ISS Phase One Activities and Manufacturing in Russia, France and Italy

NASA Image and Video Library

1996-10-07

Photographs documenting International Space Station (ISS) Phase One activities at the Russian Space Agency's (RSA) Gagarin Cosmonaut Training Center, Korolov Mission Control Center and Zvezda; and ISS and Soyuz manufacturing at RSA's Khrunichev Design Center and RSC Energiya in Moscow, Russia, the French Space Agency's (CNES) INTESPACE facility in Toulouse, France, and the Italian Space Agency's (ASI) Alenia Spazio facility in Torino, Italy. Photographs were taken by Johnson Space Center Imagery and Publications Office contractors travelling from October 7 to November 4, 1996. Includes: VIEWS FROM RSC ENERGIYA'S SPACE MUSEUM: Room with a Buran model and photographic displays (17372-374). Salyut Space Station mock-up (17376). Russian propulsion engines on display (17377-378). Russian spacecraft on display (17375, 17387-398). Graphic displays (17399-405). VIEWS FROM RSC ENERGIYA MANUFACTURING FACILITIES: Unidentified facility (17379). Mir 24 crew member Michael C. Foale, suited in a Soyuz pressure suit, ingresses the Soyuz TM-26 flight article at RSC Energiya for a fit check (17380-381). Closeups of Foale inside the Soyuz during the fit check (17382-383, 17466-467). Overhead views of RSC Energiya's Building 444 manufacturing floor where docking modules and Soyuz TM spacecraft are built (17495-498). Technicians on the Building 444 manufacturing floor assembling probe and drogue docking modules (17499-500, 17504). Technicians assembling Soyuz spacecraft (17437-439). Views of other Soyuz spacecraft (17440-441). Androgynous Peripheral Docking System (APDS) mock-up (17501-503). Closeups of a control panel, possibly for the APDS mock-up (17519-528). VIEWS FROM ZVEZDA, RSA CONTRACTOR FOR SUIT DESIGN AND SOYUZ SEAT LINERS: Mir 24 crew member Foale dons a "penguin" flight suit for a fit check (17454-456). Zvezda personnel adjust Foale's Soyuz seat and seat liner (17442). Closeup of Foale, suited in a Soyuz pressure suit, sitting on a chair (17444). Zvezda personnel strap pressure-suited Foale into his Soyuz seat (17443, 17445, 17450). Views of Foale in his Soyuz seat during a pressurized pressure suit fit check (17451-453). Views looking into a vacuum chamber where Foale, wearing pressure suit, is strapped into his Soyuz seat (17466-467). Views of Zvezda personnel working at the vacuum chamber control station during the vacuum chamber suit test (17468-471). VIEWS FROM KHRUNICHEV DESIGN CENTER: Views of a green ISS Functional Cargo Block (FGB) test article on the manufacturing floor (17529, 17532-536, 17540-544). Views of an ISS Service Module (SM) test article on the manufacturing floor (17530-531, 17537, 17539). Closeup of the SM test article docking sphere (17538). Views of the FGB flight article on the manufacturing floor during systems tests (17545-548, 17550-567). Views of technicians conducting the FGB systems tests (17549, 17557). VIEWS FROM GAGARIN COSMONAUT TRAINING CENTER: NASA astronauts work out in the cosmonaut gym at Gagarin: Closeup of ISS 2R Expedition Commander William Shepherd on a weight machine (17384). Shepherd and an unidentified man with back to camera work out with dumbbells (17386). Shepherd does pull-ups (17447). Closeup of Foale on an exercise machine (17385). Closeups of Foale exercising arms on a cycle ergometer and a weight machine (17415, 17448-449). Foale exercises on a Nordic Track (17416). Closeup of Mir 23 crew member Jerry Linenger exercising arms (17417). Wendy Lawrence exercises with dumbbells (17418). Closeup of Lawrence in a handstand position (17419). David Wolf works out on a leg press machine (17446). Views of the Mir Space Station mock-up at Gagarin: Interior views of the Mir Base Module mock-up looking toward the transfer compartment (17421-425). Mir Base Module living area mock-up (17420). Overall views of the Base Module mock-up central control station (17426-427, 17505). Closeups of switch panels on the central control station (17428-436, 17506-518). Other views from Gagarin: Personnel work at an unidentified test/trainer control station (17472-473). Linenger sits at a table next to an RSA trainer during a Mir 23 meeting (17475-476). Out-of-focus view of two subjects in the Soyuz trainer (17474). Foale examines a Mir Complex EVA Suit (Orlan) with RSA trainers during an EVA suit training class (17492-494). VIEWS FROM KOROLOV MISSION CONTROL CENTER: Various views of personnel working in the NASA Consulting Room and/or PAO Consulting Room at Korolov Mission Control Center (17457-463). VIEWS FROM INTESPACE: Exterior views of an ISS Mini Pressurized Logistics Module (MPLM) structural test article (STA) during testing at INTESPACE (17406-409, 17477, 17482-484). Technicians install hatch on the MPLM STA (17410-414). Interior views of the MPLM STA (17478-481). VIEWS FROM ALENIA SPAZIO: Closeups of MPLM flight article #1 side panels during milling and refining at Alenia Spazio (17485-488). Workers process MPLM parts at milling machines (17489-491).

Pharmacokinetics of butorphanol and evaluation of physiologic and behavioral effects after intravenous and intramuscular administration to neonatal foals.

PubMed

Arguedas, M G; Hines, M T; Papich, M G; Farnsworth, K D; Sellon, D C

2008-01-01

Despite frequent clinical use, information about the pharmacokinetics (PK), clinical effects, and safety of butorphanol in foals is not available. The purpose of this study was to determine the PK of butorphanol in neonatal foals after IV and IM administration; to determine whether administration of butorphanol results in physiologic or behavioral changes in neonatal foals; and to describe adverse effects associated with its use in neonatal foals. Six healthy mixed breed pony foals between 3 and 12 days of age were used. In a 3-way crossover design, foals received butorphanol (IV and IM, at 0.05 mg/kg) and IV saline (control group). Butorphanol concentrations were determined by high-performance liquid chromatography and analyzed using a noncompartmental PK model. Physiologic data were obtained at specified intervals after drug administration. Pedometers were used to evaluate locomotor activity. Behavioral data were obtained using a 2-hour real-time video recording. The terminal half-life of butorphanol was 2.1 hours and C0 was 33.2 +/- 12.1 ng/mL after IV injection. For IM injection, Cmax and Tmax were 20.1 +/- 3.5 ng/mL and 5.9 +/- 2.1 minutes, respectively. Bioavailability was 66.1 +/- 11.9%. There were minimal effects on vital signs. Foals that received butorphanol spent significantly more time nursing than control foals and appeared sedated. The disposition of butorphanol in neonatal foals differs from that in adult horses. The main behavioral effects after butorphanol administration to neonatal foals were sedation and increased feeding behavior.

Abdominal surgery in neonatal foals.

PubMed

Bryant, James E; Gaughan, Earl M

2005-08-01

Abdominal surgery in foals under 30 days old has become more common with improved neonatal care. Early recognition of a foal at risk and better nursing care have increased the survival rates of foals that require neonatal care. The success of improved neonatal care also has increased the need for accurate diagnosis and treatment of gastrointestinal, umbilical, and bladder disorders in these foals. This chapter focuses on the early and accurate diagnosis of specific disorders that require abdominal exploratory surgery and the specific treatment considerations and prognosis for these disorders.

Daily feeding of diclazuril top dress pellets in foals reduces seroconversion to Sarcocystis neurona.

PubMed

Pusterla, Nicola; Packham, Andrea; Mackie, Sarah; Kass, Philip H; Hunyadi, Laszlo; Conrad, Patricia A

2015-11-01

Thirty-three foals from a farm with a high exposure rate to Sarcocystis neurona were assigned to either an untreated or a diclazuril-treated group. Treated foals received daily 0.5 mg/kg of diclazuril pellets from 1 to 12 months of age. Monthly blood was tested for IgG against S. neurona using the indirect fluorescent antibody test. Following ingestion of colostral antibodies to S. neurona, there was a steady and continuous decline in seroprevalence to S. neurona until foals from both groups reached weaning age. Thereafter, the untreated foal group showed a significant increase in monthly seroprevalence compared to the diclazuril-treated foal group. The difference in temporal seroprevalence could be explained by the successful reduction of S. neurona infection in foals receiving a daily low-dose diclazuril. Copyright © 2015 Elsevier Ltd. All rights reserved.

Prevalence of twin foaling and blood chimaerism in purebred Spanish horses.

PubMed

Anaya, G; Fernández, M E; Valera, M; Molina, A; Azcona, F; Azor, P; Solé, M; Moreno-Millán, M; Demyda-Peyrás, S

2018-04-01

Twin foaling is associated with chimaerism in several domestic species and is recognised in horses. In this study, 21,097 purebred Spanish (Pura Raza Español) horse births from the 2015 to 2016 breeding season were investigated for chimaerism. Twin foaled and chimaeric individuals were assessed on the basis of foaling records, short-tandem repeat (STR) parentage test results and a sex-linked STR-based technique. Fourteen twin pregnancies with 23 twin foals born alive were identified (0.066% twin foaling prevalence), including five blood chimaeric cases (21.7%; overall prevalence 0.011%), suggesting that this genetic condition is extremely low in horses. Furthermore, no true chimaeras were detected. This is the first large scale study analysing the occurrence of chimaerism in a horse population and the first assessment of twin foaling in purebred Spanish horses. Copyright © 2018 Elsevier Ltd. All rights reserved.

Respiratory mechanics and breathing pattern in the neonatal foal.

PubMed

Koterba, A M; Kosch, P C

1987-01-01

Breathing pattern, respiratory muscle activation pattern, lung volumes and volume-pressure characteristics of the respiratory system of normal, term, neonatal foals on Days 2 and 7 of age were determined to test the hypothesis that the foal actively maintains end-expiratory lung volume (EEV) greater than the relaxation volume of the respiratory system (Vrx) because of a highly compliant chest wall. Breathing pattern was measured in the awake, unsedated foal during quiet breathing in lateral and standing positions. The typical neonatal foal breathing pattern was characterized by a monophasic inspiratory and expiratory flow pattern. Both inspiration and expiration were active, with onset of Edi activity preceding onset of inspiratory flow, and phasic abdominal muscle activity detectable throughout most of expiration. No evidence was found to support the hypothesis that the normal, term neonatal foal actively maintains EEV greater than Vrx. In the neonatal foal, normalized lung volume and lung compliance values were similar to those reported for neonates of other species, while normalized chest wall compliance was considerably lower. We conclude that the chest wall of the term neonatal foal is sufficiently rigid to prevent a low Vrx. This characteristic probably prevents the foal from having to use a breathing strategy which maintains an EEV greater than Vrx.

Clinical, serological and virological characteristics of an outbreak of paresis and neonatal foal disease due to equine herpesvirus-1 on a stud farm.

PubMed

McCartan, C G; Russell, M M; Wood, J L; Mumford, J A

1995-01-07

An outbreak of equine herpesvirus-1 (EHV-1) occurred on a large stud farm with 133 mares, 54 foals and four stallions, and at least 85 mares, 22 foals and three stallions were infected. Clinical disease was observed in 16 mares, two stallions and 13 foals and the predominant clinical signs were scrotal oedema, ataxia and loss of libido in the stallions, ataxia and recumbency in the mares and uveitis and nasal discharge in the foals, although pneumonia and colic with intussusception were also recorded at autopsy. Neurological disease was more common in the mares nursing foals (12 of 38 infected) than in barren mares (one of 46 infected). Three mares died during the outbreak and no mares that had been recumbent bred again. Control procedures were based on virological and serological testing and stringent management practices to limit the spread of infection between groups of mares and foals and away from the stud farm. There were marked antibody responses in the adult horses, but they were generally poor in the foals; three of the nine viraemic foals did not develop significant increases in the levels of circulating antibody. Recommendations are made for the management of future outbreaks.

Equine neonates have attenuated humoral and cell-mediated immune responses to a killed adjuvanted vaccine compared to adult horses.

PubMed

Ryan, Clare; Giguère, Steeve

2010-12-01

The objectives of this study were to compare relative vaccine-specific serum immunoglobulin concentrations, vaccine-specific lymphoproliferative responses, and cytokine profiles of proliferating lymphocytes between 3-day-old foals, 3-month-old foals, and adult horses after vaccination with a killed adjuvanted vaccine. Horses were vaccinated intramuscularly twice at 3-week intervals with a vaccine containing antigens from bovine viral respiratory pathogens to avoid interference from maternal antibody. Both groups of foals and adult horses responded to the vaccine with a significant increase in vaccine-specific IgGa and IgG(T) concentrations. In contrast, only adult horses and 3-month-old foals mounted significant vaccine-specific total IgG, IgGb, and IgM responses. Vaccine-specific concentrations of IgM and IgG(T) were significantly different between all groups, with the highest concentrations occurring in adult horses, followed by 3-month-old foals and, finally, 3-day-old foals. Only the adult horses mounted significant vaccine-specific lymphoproliferative responses. Baseline gamma interferon (IFN-γ) and interleukin-4 (IL-4) concentrations were significantly lower in 3-day-old foals than in adult horses. Vaccination resulted in a significant decrease in IFN-γ concentrations in adult horses and a significant decrease in IL-4 concentrations in 3-day-old foals. After vaccination, the ratio of IFN-γ/IL-4 in both groups of foals was significantly higher than that in adult horses. The results of this study indicate that the humoral and lymphoproliferative immune responses to this killed adjuvanted vaccine are modest in newborn foals. Although immune responses improve with age, 3-month-old foals do not respond with the same magnitude as adult horses.

Impact of reproductive efficiency over time and mare financial value on economic returns among Thoroughbred mares in central Kentucky.

PubMed

Bosh, K A; Powell, D; Neibergs, J S; Shelton, B; Zent, W

2009-12-01

There have been no studies reporting the impact of reproductive efficiency and mare financial value on economic returns. To explore the economic consequences of differences in reproductive efficiency over time in the Thoroughbred mare. Complete production records for 1176 mares were obtained. Production history and drift in foaling date were calculated. Multiple logistic regression was used to identify factors influencing the probability of producing a registered foal in 2005. The 'net present value' and 'internal rate of return' were calculated for economic scenarios involving different initial mare financial values, levels of reproductive efficiency, and durations of investment. Among mares that did not produce a foal every year (63%), the mean time before failing to produce a registered foal was 3.4 years. The majority of mares drifted later in their foaling dates in subsequent foaling seasons. Increasing mare age, foaling after 1st April, needing to be mated multiple times during the season, and producing a lower number of foals in continuous sequence during previous years decreased the probability of producing a registered foal. Over a 7 year investment period, live foals must be produced in all but one year to yield a positive financial return. Profitability was highest among mares of greatest financial value. Mares are long-term investments due to the extended period before there is a return on the investment. Improving our understanding of mare, stallion and management factors that affect the likelihood of producing a live foal are critical to ensuring a positive financial return. Additional work is needed to test the robustness of the study's conclusions when the cost and revenue assumptions are varied. This information can assist in assessing mare profitability and developing management strategies to maximise profitability.

[Energy intake and body weight development of Warmblood foals that changed stud at weaning].

PubMed

Mack, J K; Remler, H P; Senckenberg, E; Kienzle, E

2014-01-01

This study investigated the energy requirements of Warmblood foals with a change of the stud at weaning. Nine colts purchased at weaning participated in the study aged approximately 6 months to 1 year. They were transported to the stud by their breeders either having been separated from their dams in their home stable or upon arrival at the stud. The foals were offered a late first cut of haylage, oats and foal starter feed. To ensure individual feeding of concentrates, the foals were tethered twice daily. The total combined haylage intake of all foals per day was recorded. Individual concentrate intake, body weight and body condition score (BCS) were documented at 4-week intervals. The total energy intake was 74 MJ digestible energy (68 MJ metabolisable energy) per animal per day. The foals had been delivered at the stud with a comparably low body weight (285 ± 30 kg) and BCS (4.2 ± 0.4 on a scale from 1 to 9). At the end of the study, aged 319 ± 22 days, they attained an average body weight of 326 ± 24 kg and a BCS of 4.2 ± 0.4. The energy intake of the foals of this study was higher and their body weight development slower than in foals of a parallel study, which were born and raised in the stud and therefore exposed to less stressful weaning conditions. Foals with a comparatively low body weight and BCS at weaning in combination with further stressors need considerably more energy than foals that undergo less stressful weaning conditions.

The FGF-23/klotho axis and its relationship with phosphorus, calcium, vitamin D, PTH, aldosterone, severity of disease, and outcome in hospitalised foals.

PubMed

Kamr, A M; Dembek, K A; Hildreth, B E; Morresey, P R; Rathgeber, R A; Burns, T A; Zaghawa, A A; Toribio, R E

2018-04-16

Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. The aims of this study were to measure serum FGF-23 and klotho concentrations and determine their association with serum phosphorus, total calcium (TCa), vitamin D metabolite [25(OH)D, 1,25(OH) 2 D], PTH, and aldosterone concentrations, disease severity, and mortality in hospitalised foals. Prospective, multicentre, cross-sectional study. A total of 91 foals ≤72 h old were classified as hospitalised (n = 81; 58 septic; 23 sick non-septic [SNS]) and healthy (n = 10). Blood samples were collected on admission. Hormone concentrations were determined by immunoassays. Serum FGF-23, PTH, phosphorus, and aldosterone concentrations were higher while klotho, 25(OH)D, 1,25(OH) 2 D, and TCa concentrations were lower in septic and SNS compared to healthy foals (P<0.05). In hospitalised and septic foals, increased FGF-23 and aldosterone concentrations were associated with high phosphorus and PTH but not with TCa and vitamin D metabolite concentrations. Hospitalised foals with the highest FGF-23 and lowest klotho concentrations were more likely to die (odds ratio (OR): 3.3; 95% confidence interval (CI): 1.1-10.3 and OR: 3.1; CI: 1.1-8.0, respectively). Blood gas, ionised calcium, blood culture information not being available for many foals, and use of the sepsis score to classify hospitalised foals. Imbalances in the FGF-23/klotho axis may contribute to mineral dyshomeostasis and disease progression in critically ill foals. Elevated FGF-23 and reduced klotho, together with high phosphorus and PTH concentrations suggests FGF-23 resistance. FGF-23 and klotho are good markers of disease severity and likelihood of mortality in hospitalised foals. Aldosterone may influence phosphorus and PTH dynamics in hospitalised foals. Routine measurement of phosphorus concentrations in sick foals is recommended. © 2018 EVJ Ltd.

The STS-103 crew address family and friends at Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

The STS-103 crew address family and friends at Launch Pad 39B. From left to right are Pilot Scott J. Kelly, Commander Curtis L. Brown Jr., and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Jean-Frangois Clervoy of France , Claude Nicollier of Switzerland and Steven L. Smith. Nicollier and Clervoy are with the European Space Agency. In the background is Space Shuttle Discovery, alongside the lighted Fixed Service Structure. The STS-103 mission, to service the Hubble Space Telescope, is scheduled for launch Dec. 17 at 8:47 p.m. EST from Launch Pad 39B. Mission objectives include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. The mission is expected to last about 8 days and 21 hours. Discovery is expected to land at KSC Sunday, Dec. 26, at about 6:25 p.m. EST.

STS-103 Discovery reaches to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

Space Shuttle Discovery arrives at Launch Pad 39B where the orbiter, external tank and solid rocket boosters will undergo final preparations for the STS-103 launch. The mission is a 'call-up' due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, both with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST aboard Space Shuttle Discovery.

STS-103 Discovery crawls to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

Space Shuttle Discovery makes the turn toward Launch Pad 39B on its 4.2-mile (6.8 kilometer) trek atop the mobile launcher platform and crawler transporter. Once at the pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the STS-103 launch targeted for Dec. 6, 1999, at 2:37 a.m. EST. The mission is a 'call-up' due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, both with the European Space Agency.

STS-103 Discovery reaches to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

At Launch Pad 39B, Space Shuttle Discovery towers against the hazy blue sky after a seven-hour trek from the Vehicle Assembly Building. The orbiter, external tank and solid rocket boosters will undergo final preparations for the STS-103 launch. The mission is a 'call-up' due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, both with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

STS-86 crew member Wolf dons a gas mask during TCDT

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf dons a gas mask as part of training exercises during the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. Wolf is wearing the patch from his first and only mission to date, STS-58 in 1993. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25.

STS-86 Mission Specialist David Wolf suits up

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf gets assistance from a suit technician while donning his orange launch and entry suit in the Operations and Checkout Building. This will be Wolfs second flight. He and the six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff on a 10-day mission slated to be the seventh docking of the Space Shuttle with the Russian Space Station Mir. Wolf will transfer to the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who will return to Earth aboard Atlantis with the rest of the STS-86 crew. Wolf is expected to live and work aboard the Russian space station for about four months.

Gemini Simulator and Neil Armstrong

NASA Image and Video Library

1963-11-06

Astronaut Neil Armstrong (left) was one of 14 astronauts, 8 NASA test pilots, and 2 McDonnell test pilots who took part in simulator studies. Armstrong was the first astronaut to participate (November 6, 1963). A.W. Vogeley described the simulator in his paper "Discussion of Existing and Planned Simulators For Space Research," "Many of the astronauts have flown this simulator in support of the Gemini studies and they, without exception, appreciated the realism of the visual scene. The simulator has also been used in the development of pilot techniques to handle certain jet malfunctions in order that aborts could be avoided. In these situations large attitude changes are sometimes necessary and the false motion cues that were generated due to earth gravity were somewhat objectionable; however, the pilots were readily able to overlook these false motion cues in favor of the visual realism." Roy F. Brissenden, noted in his paper "Initial Operations with Langley's Rendezvous Docking Facility," "The basic Gemini control studies developed the necessary techniques and demonstrated the ability of human pilots to perform final space docking with the specified Gemini-Agena systems using only visual references. ... Results... showed that trained astronauts can effect the docking with direct acceleration control and even with jet malfunctions as long as good visual conditions exist.... Probably more important than data results was the early confidence that the astronauts themselves gained in their ability to perform the maneuver in the ultimate flight mission." Francis B. Smith, noted in his paper "Simulators for Manned Space Research," "Some major areas of interest in these flights were fuel requirements, docking accuracies, the development of visual aids to assist alignment of the vehicles, and investigation of alternate control techniques with partial failure modes. However, the familiarization and confidence developed by the astronaut through flying and safely docking the simulator during these tests was one of the major contributions. For example, it was found that fuel used in docking from 200 feet typically dropped from about 20 pounds to 7 pounds after an astronaut had made a few training flights." -- Published in Barton C. Hacker and James M. Grimwood, On the Shoulders of Titans: A History of Project Gemini, NASA SP-4203; A.W. Vogeley, "Discussion of Existing and Planned Simulators For Space Research," Paper presented at the Conference on the Role of Simulation in Space Technology, August 17-21, 1964; Roy F. Brissenden, "Initial Operations with Langley's Rendezvous Docking Facility," Langley Working Paper, LWP-21, 1964; Francis B. Smith, "Simulators for Manned Space Research," Paper presented at the 1966 IEEE International convention, March 21-25, 1966.

Christa McAuliffe meets other STS 51-L crewmembers

NASA Image and Video Library

1985-09-10

S85-39943 (9 Sept. 1985) --- Sharon Christa McAuliffe, STS-51L citizen observer/payload specialist representing the Teacher in Space Program, meets the other STS-51L crew members. The crew members pictured are (l.-r.) astronauts Michael J. Smith, pilot; Ronald E. McNair, mission specialist; and Francis R. (Dick) Scobee, mission commander. Photo credit: NASA

Effect of butorphanol on thermal nociceptive threshold in healthy pony foals.

PubMed

McGowan, K T; Elfenbein, J R; Robertson, S A; Sanchez, L C

2013-07-01

Pain management is an important component of foal nursing care, and no objective data currently exist regarding the analgesic efficacy of opioids in foals. To evaluate the somatic antinociceptive effects of 2 commonly used doses of intravenous (i.v.) butorphanol in healthy foals. Our hypothesis was that thermal nociceptive threshold would increase following i.v. butorphanol in a dose-dependent manner in both neonatal and older pony foals. Seven healthy neonatal pony foals (age 1-2 weeks), and 11 healthy older pony foals (age 4-8 weeks). Five foals were used during both age periods. Treatments, which included saline (0.5 ml), butorphanol (0.05 mg/kg bwt) and butorphanol (0.1 mg/kg bwt), were administered i.v. in a randomised crossover design with at least 2 days between treatments. Response variables included thermal nociceptive threshold, skin temperature and behaviour score. Data within each age period were analysed using a 2-way repeated measures ANOVA, followed by a Holm-Sidak multiple comparison procedure if warranted. There was a significant (P<0.05) increase in thermal threshold, relative to Time 0, following butorphanol (0.1 mg/kg bwt) administration in both age groups. No significant time or treatment effects were apparent for skin temperature. Significant time, but not treatment, effects were evident for behaviour score in both age groups. Butorphanol (0.1 mg/kg bwt, but not 0.05 mg/kg bwt) significantly increased thermal nociceptive threshold in neonatal and older foals without apparent adverse behavioural effects. Butorphanol shows analgesic potential in foals for management of somatic painful conditions. © 2012 EVJ Ltd.

Concentrations of amino acids in plasma and whole blood in response to food deprivation and refeeding in healthy two-day-old foals.

PubMed

Zicker, S C; Rogers, Q R

1994-07-01

Concentrations of amino acids in plasma and whole blood in response to 10 hours of food deprivation were determined in healthy 2-day-old foals (n = 8) and were compared with control values in foals of the same age (n = 8) allowed free access to suckle. In addition, response of concentrations of amino acids in plasma to 15 minutes of free-access suckling was determined at the end of the 10-hour period in both groups. Response of 13 amino acids in plasma of food-deprived foals was significantly (P < 0.05) different, compared with that in control foals. Concentrations of 3 amino acids (alanine, glycine, and phenylalanine) in plasma increased significantly (P < 0.05), whereas concentrations of 7 amino acids (asparagine, citrulline, histidine, ornithine, proline, tryptophan, and tyrosine) in plasma decreased significantly (P < 0.05) during food deprivation. Response of concentrations of 2 amino acids (glycine and histidine) in whole blood was significantly (P < 0.05) different from that in plasma of food-deprived vs control foals. Refeeding of food-deprived foals resulted in significantly (P < 0.05) different responses for concentrations of all but 2 amino acids (cystine and taurine) in plasma, compared with responses in controls. Changes in concentrations of amino acids in plasma and whole blood of foals in response to food deprivation are similar to those in foals with septicemia and in children with grade 1 or 2 kwashiorkor. The significantly different response of food-deprived foals to refeeding may be attributable to increased protein intake or altered physiologic state.

Gastroduodenal ulceration in foals.

PubMed

Becht, J L; Byars, T D

1986-07-01

Gastroduodenal ulceration is becoming recognised as an important disease in foals during the first few months of life. Aetiopathogenesis is presumed to be similar to peptic disease in humans associated with back diffusion of hydrogen ions into the mucosa. Many factors have been incriminated as predisposing foals to ulceration but few have been proven. To date, use of non-steroidal anti-inflammatory agents has been the only documented cause of gastroduodenal ulceration in foals. The clustering of affected foals on certain farms suggests an infectious aetiology but attempts to identify a causative organism have been unsuccessful. Four clinical syndromes defined for foals with gastroduodenal ulceration include: silent ulcers, which occur most often in the non-glandular stomach along the margo plicatus and are identified as incidental findings at necropsy; active ulcers which are often manifested by abdominal pain, excessive salivation and bruxism; perforating ulcers which usually result in a severe, diffuse peritonitis; and pyloric or duodenal obstruction from a healing ulcer. General approaches to therapy of a foal with active ulceration consist of reduction of gastric acidity and enhancement of mucosal protection. Antacids and type 2 histamine receptor antagonists are used most often to neutralise or decrease acid secretion, respectively. Sucralfate, a locally active sulphated sucrose preparation, is commonly used as a cytoprotective agent. The efficacy and safety of many products used have not been evaluated adequately in foals. Perforating ulcers are usually associated with death or humane destruction of the foal because of fulminating peritonitis. Surgical intervention and bypass procedures are indicated in foals that develop pyloric or duodenal obstructions from healing ulcers.

Epidemiology of equine Cryptosporidium and Giardia infections.

PubMed

Xiao, L; Herd, R P

1994-01-01

Prevalence and infection patterns of Cryptosporidium and Giardia infections in horses were studied by a direct immunofluorescence staining method. Faecal examinations of 222 horses of different age groups revealed Cryptosporidium infection rates of 15-31% in 66 foals surveyed in central Ohio, southern Ohio and central Kentucky, USA. Only 1 of 39 weanlings, 0 of 46 yearlings, and 0 of 71 mares were positive. Giardia infection was found in all age groups, although the infection rates for foals were higher (17-35%). Chronological study of infection in 35 foals showed that foals started to excrete Cryptosporidium oocysts between 4 and 19 weeks and Giardia cysts between 2 and 22 weeks of age. The cumulative infection rates of Cryptosporidium and Giardia in foals were each 71%. Some foals were concurrently infected with both parasites and excretion of oocysts or cysts was intermittent and long-lasting. The longest duration of excretion was 14 weeks for Cryptosporidium and 16 weeks for Giardia. Excretion of Cryptosporidium oocysts stopped before weaning, while excretion of Giardia cysts continued thereafter. Infected foals were considered the major source of Cryptosporidium infection in foals, whereas infected mares were deemed the major source of Giardia infection in foals. The high infection rate of Giardia in nursing mares suggested a periparturient relaxation of immunity. The results indicated that Cryptosporidium and Giardia infections are common in horses.

Allopregnanolone infusion induced neurobehavioural alterations in a neonatal foal: is this a clue to the pathogenesis of neonatal maladjustment syndrome?

PubMed

Madigan, J E; Haggettt, E F; Pickles, K J; Conley, A; Stanley, S; Moeller, B; Toth, B; Aleman, M

2012-02-01

Increased plasma progestagen concentrations have been reported in foals with neonatal maladjustment syndrome (NMS). These steroids may cross the blood-brain barrier and have dampening effects in the central nervous system. To evaluate if the infusion of a progesterone derivative (allopregnanolone) in a healthy neonatal foal would induce clinical signs compatible with NMS. A healthy neonatal foal from a healthy mare with a normal gestation (length, no complications), birth and placenta was infused with allopregnanolone to observe its neurobehavioural effects. Heparinised blood samples were collected pre- and post infusion to determine various progestagen concentrations using liquid chromatography mass spectrometry. A second healthy neonatal foal was infused with ethanol and saline for comparison of clinical observations. Infusion of allopregnanolone resulted in obtundation, lack of affinity for the mare and decreased response to external stimuli. These effects were short-lasting and associated with measurable concentrations of progestagens. Infusion of a steroid metabolite to a healthy neonatal foal resulted in neurobehavioural alterations compatible with those observed in foals with NMS. These findings suggest that increased progestagen concentrations may be responsible for some of the behavioural changes observed in foals with NMS.

KSC-97PC853

NASA Image and Video Library

1997-05-24

STS-84 crew members give a "thumbs up" to press representatives and other onlookers on KSC’s Runway 33 after landing of the successful nine-day mission. From left, are Mission Specialist Jean-Francois Clervoy of the European Space Agency, Pilot Eileen Marie Collins, Commander Charles J. Precourt, Mission Specialist Elene V. Kondakova of the Russian Space Agency, and Mission Specialist Carlos I. Noriega. Not shown are Mission Specialist Edward Tsang Lu and returning astronaut and Mir 23 crew member Jerry M. Linenger. STS-84 was the sixth docking of the Space Shuttle with the Russian Space Station Mir. The Space Shuttle orbiter Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced Linenger, who has been on the Russian space station since Jan. 15. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

STS-103 crew take part in CEIT

NASA Technical Reports Server (NTRS)

1999-01-01

In the Payload Hazardous Servicing Facility, STS-103 Mission Specialist Steven L. Smith (right) and other members of the crew look over new Multi-Layer Insulation (MLI) intended for the Hubble Space Telescope. The seven-member crew, taking part in a Crew Equipment Interface Test, are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-Frangois Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a 'call-up' due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with the MLI. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review.

Outcome of tactile conditioning of neonates, or "imprint training" on selected handling measures in foals.

PubMed

Spier, Sharon J; Berger Pusterla, Jeannine; Villarroel, Aurora; Pusterla, Nicola

2004-11-01

Behavioural reactions to selected handling procedures were compared between conditioned, or imprint-trained, and untrained foals raised on the same farm. Nineteen randomly chosen healthy foals were imprint trained at birth and 24 h later (Group A). Twenty-one similar foals that were not imprint-trained served as age-matched controls (Group B). Training began within 10 min of birth and consisted of touch desensitization by gentle rubbing. Each tactile stimulus was repeated 30-50 times over 45-60 min, until the foal no longer resisted the procedure and appeared relaxed. The procedure was then repeated at 24 h of age. At that time a physical examination and blood analysis were performed to assess the foals' health status. Group B animals were not handled except for a brief physical examination and blood analysis at 24 h of age. Thereafter all foals were kept on pastures with their dams with no further handling until they were three months of age. Any foals handled for other reasons before that time were excluded from the study. At three months, each of the 28 foals that completed the study experienced the following handling procedures: acceptance of restraint, haltering, complete physical examination, acceptance of a plastic rebreathing bag, touching the whole body, intramuscular vaccination in the neck, intranasal vaccination, and deworming with oral paste. Response to each procedure was scored (1=not resistant, 2=low resistance, 3=strong resistance, 4=not possible without major physical restraint). Conditioned foals (Group A) were significantly less resistant to touching the front and hind legs and picking up the hind feet (P < 0.05). The administration of vaccines and paste dewormer and the collection of blood were tolerated by the majority of the foals of both groups with no or low resistance. It appeared that neonatal imprint training resulted in a learned behaviour that resulted in decreased self-defence responses towards handling the limbs at three months of age.

Activity of closantel in the prevention of Gasterophilus and Strongylus vulgaris larval infections in equine foals and yearlings.

PubMed

Guerrero, J; Newcomb, K; Seibert, B P; Michael, B F

1985-01-01

Two controlled tests were conducted in equine foals and yearlings to determine the optimal oral dosage and the duration of activity of closantel for the prevention of Gasterophilus spp larval infections. Additional data were collected on the activity of closantel against Strongylus vulgaris larval infections. In experiment 1, 12 foals and 12 yearlings were equally allocated to 4 experimental groups, and were given oral treatments with closantel at dosages of 0 (nontreated controls), 2, 5, or 8 mg/kg of body weight every 2 months during bot season. The foals and yearlings were allowed to graze on open pasture throughout the experiment to provide a natural source for bot and helminth infections. All animals were euthanatized and necropsied 6 weeks after the final treatment. Closantel was highly effective (98.6% to 100%) at all doses in preventing Gasterophilus spp larval infections in the foals, but only the 8 mg/kg dose had significant (P less than 0.05) activity (99.7%) in the yearlings. This dose also significantly reduced the numbers of 4th-stage and immature adult S vulgaris (86.0%) in the mesenteric arteries as compared with nontreated controls. In experiment 2, 9 foals and 9 yearlings received a single oral treatment of 8 mg of closantel/kg of body weight; 3 foals and 3 yearlings were kept as nontreated controls. Groups of 6 treated (3 foals, 3 yearlings) and 2 control (1 foal, 1 yearling) animals were euthanatized and necropsied 1, 2, and 3 months after treatment. Closantel remained effective for 2 months in preventing infections of G intestinalis larvae in these foals and yearlings. Clinical signs of toxicosis were not observed in the treated animals of either study.

Dysphagia associated with presumed pharyngeal dysfunction in 16 neonatal foals.

PubMed

Holcombe, S J; Hurcombe, S D; Barr, B S; Schott, H C

2012-02-01

Dysphagia due to pharyngeal dysfunction occurs in human neonates and is associated with prematurity and hypoxic episodes. This syndrome probably occurs in neonatal foals but has not been reported. The objectives of this study were to describe 1) a series of neonatal foals with dysphagia due to pharyngeal dysfunction; 2) the progression, treatment and resolution of the dysphagia; 3) the comorbidities; and 4) the prognosis for life and athleticism for affected foals. Records from 3 referral equine hospitals were reviewed from neonatal foals with dysphagia of pharyngeal origin. Inclusion criteria were a normal to strong suckle, dysphagia evidenced by milk at the nostrils after nursing the dam, and endoscopic examination of the airway. Foals with mechanical reasons for dysphagia, botulism or hyperkalaemic periodic paralysis were not included. Sixteen neonatal foals qualified for the study. Eight (50%) were premature and/or diagnosed with hypoxic ischaemic encephalopathy. Twelve (75%) had aspiration pneumonia. Fifteen foals were discharged alive from the hospital, nursing the mare with no evidence of dysphagia (n = 14), or mild dysphagia (n = 1), a mean +/- s.d. of 7 +/- 6 days (median = 6.3 days, range 0-22 days) after hospital admission. One foal was subjectedto euthanasia in hospital. Follow-up nformation was available for 14 animals. Thirteen of 16 (81%) were alive and included one yearling and 12 horses >2 years old. Seven of the 14 (50%) were racing, training or in work, and 6 horses were pets, breeding animals or had unknown athletic status. Two had laryngeal deficits. One foal was subjected to euthanasia within weeks of discharge from the hospital due to aspiration pneumonia. Dysphagia related to pharyngeal dysfunction occurs in equine neonates and can resolve, but may require days to weeks of supportive care. Prognosis for life is favourable and for athleticism fair.

Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals.

PubMed

Hart, Kelsey A; Dirikolu, Levent; Ferguson, Duncan C; Norton, Natalie A; Barton, Michelle H

2012-01-01

To compare daily endogenous cortisol production rate and the pharmacokinetics of an i.v. bolus of hydrocortisone between neonatal foals and adult horses. 10 healthy full-term 2- to 4-day-old foals and 7 healthy adult horses. Blood samples were collected from each horse every 15 to 20 minutes for 24 hours for determination of 24-hour mean cortisol concentration. Afterward, dexamethasone (0.08 mg/kg) was administered i.v. to suppress endogenous cortisol production. Twelve hours afterward, hydrocortisone sodium succinate (1.0 mg/kg) was administered as a rapid i.v. bolus and serial blood samples were collected to determine hydrocortisone pharmacokinetics. Cortisol concentrations, daily cortisol production rate, and hydrocortisone pharmacokinetics were determined, and results were compared between adult horses and foals. The mean ± SD 24-hour cortisol concentration was significantly lower in foals (20 ± 4 ng/mL) than in horses (26 ± 6 ng/mL), but the daily cortisol production rate was significantly greater in foals (6,710 ± 320 ng/kg/d) than in horses (2,140 ± 400 ng/kg/d). For hydrocortisone, foals had a significantly greater volume of distribution at steady state (1.92 ± 1.11 L/kg) and total body clearance (1.39 ± 0.108 L/kg/h) and significantly lower peak plasma concentration (1,051 ± 343 ng/mL) than did horses (0.58 ± 0.15 L/kg, 0.349 ± 0.065 L/kg/h, and 8,934 ± 3,843 ng/mL, respectively). Important differences were detected in cortisol production and metabolism between neonatal foals and adult horses consistent with lower plasma protein binding of cortisol in foals. This decrease may contribute to cortisol insufficiency during prolonged critical illness in neonatal foals.

Intramuscular Administration of a Synthetic CpG-Oligodeoxynucleotide Modulates Functional Responses of Neutrophils of Neonatal Foals

PubMed Central

Cohen, Noah D.; Bourquin, Jessica R.; Bordin, Angela I.; Kuskie, Kyle R.; Brake, Courtney N.; Weaver, Kaytee B.; Liu, Mei; Felippe, M. Julia B.; Kogut, Michael H.

2014-01-01

Neutrophils play an important role in protecting against infection. Foals have age-dependent deficiencies in neutrophil function that may contribute to their predisposition to infection. Thus, we investigated the ability of a CpG-ODN formulated with Emulsigen to modulate functional responses of neutrophils in neonatal foals. Eighteen foals were randomly assigned to receive either a CpG-ODN with Emulsigen (N = 9) or saline intramuscularly at ages 1 and 7 days. At ages 1, 3, 9, 14, and 28, blood was collected and neutrophils were isolated from each foal. Neutrophils were assessed for basal and Rhodococcus equi-stimulated mRNA expression of the cytokines interferon-γ (IFN-γ), interleukin (IL)-4, IL-6, and IL-8 using real-time PCR, degranulation by quantifying the amount of β-D glucuronidase activity, and reactive oxygen species (ROS) generation using flow cytometry. In vivo administration of the CpG-ODN formulation on days 1 and 7 resulted in significantly (P<0.05) increased IFN-γ mRNA expression by foal neutrophils on days 3, 9, and 14. Degranulation was significantly (P<0.05) lower for foals in the CpG-ODN-treated group than the control group at days 3 and 14, but not at other days. No effect of treatment on ROS generation was detected. These results indicate that CpG-ODN administration to foals might improve innate and adaptive immune responses that could protect foals against infectious diseases and possibly improve responses to vaccination. PMID:25333660

Enteric Pathogens and Coinfections in Foals with and without Diarrhea

PubMed Central

Olivo, Giovane; Lucas, Thays Mizuki; Borges, Alexandre Secorun; Silva, Rodrigo Otávio Silveira; Lobato, Francisco Carlos Faria; Siqueira, Amanda Keller; da Silva Leite, Domingos; Brandão, Paulo Eduardo; de Oliveira-Filho, José Paes

2016-01-01

Diarrhea is a major clinical problem affecting foals up to 3 months of age. The aim of this study was to identify enteric microorganisms involved in monoinfections and coinfections and the associated virulence factors in healthy and diarrheic foals. Diarrheic (D) (n = 56) and nondiarrheic (ND) foals (n = 60) up to three months of age were studied. Fecal samples were analyzed for identification of infectious agents (microbiological culturing, molecular techniques, and microscopic analyses). Escherichia coli fimH (30% versus 25%), Salmonella spp. (25% versus 7%), Strongyloides westeri (25% versus 25%), Clostridium perfringens type A (21% versus 10%), E. coli ag43 (20% versus 35%), Strongylus (11% versus 18%), and vapA-positive Rhodococcus equi (5% versus 2%) were the most frequent enteric pathogens detected in D and ND foals, respectively. The frequency of toxin A-positive C. perfringens was significantly increased in the D (p = 0.033) compared with the ND animals. R. equi strains harboring virulent plasmids were also identified (VapA 85-kb type I and VapA 87-kb type I) in D and ND foals. Coinfections were observed in 46% of the D and 33% of the ND foals. Our results demonstrate the great diversity of enteric pathogens, virulence factors, and coinfections involved in enteric infections of foals. PMID:28116290

Immunization by intrabronchial administration to 1-week-old foals of an unmarked double gene disruption strain of Rhodococcus equi strain 103+.

PubMed

Pei, Yanlong; Nicholson, Vivian; Woods, Katharine; Prescott, John F

2007-11-15

Rhodococcus equi causes fatal granulomatous pneumonia in foals and immunocompromised animals and humans. However, there is no effective vaccine against this infection. In this study, the chromosomal genes isocitrate lyase (icl) and cholesterol oxidase (choE) were chosen as targets for mutation and assessment of the double mutant as an intrabronchial vaccine in 1-week-old foals. Using a modification of a suicide plasmid previously developed in this laboratory, we developed a choE-icl unmarked deletion mutant of R. equi strain 103+. Five 1-week-old foals were infected intrabronchially with the mutant and challenged intrabronchially with the parent, virulent, strain 2 weeks later. Three of the foals were protected against pneumonia caused by the virulent strain, but the other two foals developed pneumonia caused by the mutant strain during the post-challenge period. Since infection of 3-week-old foals by an icl mutant in an earlier study had shown complete attenuation of the strain, we conclude that a proportion of foals in the 1st week or so of life are predisposed to developing R. equi pneumonia because of an inability to mount an effective immune response. This has been suspected previously but this is the first time that this has been demonstrated experimentally.

Effects of high doses of oxytetracycline on metacarpophalangeal joint kinematics in neonatal foals.

PubMed

Kasper, C A; Clayton, H M; Wright, A K; Skuba, E V; Petrie, L

1995-07-01

Thirteen clinically normal Belgian-type foals were used to study the effects of high doses of oxytetracycline on metacarpophalangeal joint kinematics. Seven foals (treatment group) received 2 doses of oxytetracycline (3 g, IV). The first dose was given when foals were 4 days old; the second dose was given 24 hours later. Six foals (control group) received 2 doses of saline (0.9% NaCl) solution (15 ml, IV) at equivalent time periods. All foals were videotaped at a walk twice: immediately prior to the first treatment and 24 hours after the second treatment. The tapes were digitized, and metacarpophalangeal joint angle was measured along the palmar surface of the limb during 3 strides. The angular data were normalized for time, and data from the 3 strides were averaged to describe a representative stride. Repeated measures ANOVA was used to test for differences between groups and within groups over time. Values for stride duration, stance phase percentage, and minimum metacarpophalangeal joint angle obtained before treatment were not significantly different from values obtained after treatment. Maximum metacarpophalangeal joint angle, which occurred during the stance phase of the stride, and range of joint motion were significantly increased for foals in the treatment group, compared with foals in the control group.

Prevalence of netF-positive Clostridium perfringens in foals in southwestern Ontario.

PubMed

Finley, Abigail; Gohari, Iman Mehdizadeh; Parreira, Valeria R; Abrahams, Miranda; Staempfli, Henry R; Prescott, John F

2016-07-01

NetF-producing Clostridium perfringens have recently been identified as a cause of necrotizing enteritis in neonatal foals, but little is known about its prevalence in clinically normal foals. Foals (n = 88) ranging in age from < 1 wk to 2 to 4 mo (median age 2 to 4 wk) on 8 horse-breeding farms in Ontario were examined on 1 or 2 occasions for the presence of C. perfringens. Of the foals that tested positive, 5 isolates (n = 675) were examined for the netF and enterotoxin (cpe) genes. Colonization by C. perfringens was most marked in foals < 1 wk of age [4.85 ± 2.70 log10 colony-forming units (CFU)] and declined markedly over time (1.23 ± 1.06 log10 CFU at 1 to 2 mo of age). Only 2 isolates possessed the cpe gene and none possessed netF. We concluded that netF-positive C. perfringens does not colonize young foals with any detectable frequency in Ontario and this organism is not likely to be adapted to the intestine of the horse.

Prevalence of netF-positive Clostridium perfringens in foals in southwestern Ontario

PubMed Central

Finley, Abigail; Gohari, Iman Mehdizadeh; Parreira, Valeria R.; Abrahams, Miranda; Staempfli, Henry R.; Prescott, John F.

2016-01-01

NetF-producing Clostridium perfringens have recently been identified as a cause of necrotizing enteritis in neonatal foals, but little is known about its prevalence in clinically normal foals. Foals (n = 88) ranging in age from < 1 wk to 2 to 4 mo (median age 2 to 4 wk) on 8 horse-breeding farms in Ontario were examined on 1 or 2 occasions for the presence of C. perfringens. Of the foals that tested positive, 5 isolates (n = 675) were examined for the netF and enterotoxin (cpe) genes. Colonization by C. perfringens was most marked in foals < 1 wk of age [4.85 ± 2.70 log10 colony-forming units (CFU)] and declined markedly over time (1.23 ± 1.06 log10 CFU at 1 to 2 mo of age). Only 2 isolates possessed the cpe gene and none possessed netF. We concluded that netF-positive C. perfringens does not colonize young foals with any detectable frequency in Ontario and this organism is not likely to be adapted to the intestine of the horse. PMID:27408339

A comparison of the carcass and meat quality of Martina Franca donkey foals aged 8 or 12 months.

PubMed

Polidori, Paolo; Pucciarelli, Stefania; Ariani, Ambra; Polzonetti, Valeria; Vincenzetti, Silvia

2015-08-01

The effects of slaughter age (8 vs 12 months) were investigated on meat and carcass quality obtained from Martina Franca donkey foals. Sixteen male foals were used, eight were slaughtered at 8 months of age with a mean (±s.e.) final body weight of 101±18kg and the remaining 8 foals slaughtered at 12 months of age with a mean final body weight of 122±13kg. Carcass weight and dressing percentage were higher (P<0.05) in older foals. Shear force value was lower (P<0.05) in donkeys slaughtered at 8 months of age (54.03N) compared to the same muscle Longissimus Thoracis et Lumborum (LTL) collected in older animals (62.66N). Muscle glycogen content was higher (P<0.05) in foals slaughtered at 12months of age. Donkey foal meat showed an interesting content of essential amino acids and a notable percentage of unsaturated fatty acids in both groups of animals, giving a high nutritional value to this alternative red meat. Copyright © 2015 Elsevier Ltd. All rights reserved.

Specific Immune Response of Mares and their Newborn Foals to Actinobacillus spp. Present in the Oral Cavity

PubMed Central

Sternberg, S

2001-01-01

Oral swab samples, serum and colostrum was taken from 15 mares and 14 of their foals, within 24 h of birth. The presence of antibody against Actinobacillus spp. isolated from the oral cavity was investigated using agar gel immunodiffusion. Antibodies against 48 out of the 77 Actinobacillus isolates from all horses in the study were present in the respective sera of 13 mares and 9 foals. In 11 mother-foal pairs, the antibody content of the foal serum was similar to that of the mare, and in 9 cases this was reflected in the antibody content of colostrum from the mare. The results indicate that an immune response to Actinobacillus spp. colonising the oral cavity is present in many adult horses and that this immune response can be transferred from mother to foal via colostrum. PMID:11503368

Demography of the Pryor Mountain wild horses, 1993-2007

USGS Publications Warehouse

Roelle, James E.; Singer, Francis J.; Zeigenfuss, Linda C.; Ransom, Jason I.; Coates-Markle, Linda; Schoenecker, Kathryn A.

2010-01-01

Wild horses (Equus caballus) at Pryor Mountain were studied by direct observation from 1993 through 2007. All horses present were individually identifiable on the basis of coat coloration, head and leg markings, gender, and band associations. Of the 609 horses either present prior to foaling in 1993 or born since, ages were precisely known for 491 (observed as a foal). Ages for 52 horses were estimated through tooth eruption and wear patterns, and for the remaining 66 horses through body size, morphology, and anecdotal evidence concerning when they were present on the range. At varying intensities, never less than 30 days per year, all horses were inventoried and their band associations noted. Foals were paired with dams based on observations of attachment during the early days and weeks of life. Year of death was determined by identification of the carcass where possible. In the absence of finding a carcass, an animal that was not observed for 2 years was considered to have died in the year that it went missing. Animals that were removed from the herd and mares that were part of a contraception study were excluded from calculations of survival and foaling rates, respectively, as appropriate. The average prefoaling population over the 15 years of the study was 148.8 animals (range = 120-187), and the annual foal crop averaged 32.1 (range = 23-40). Large removals (19-60 animals) in four years helped maintain the herd at this level; apparent growth rate (calculated as though removals had not occurred) was 9.6 percent annually (? = 1.096, range = 0.977-1.220). This annual growth rate is relatively low compared to that for many western horse herds, at least in part because of a decline in foal survival. Sex ratio of the foal crop varied widely among years, but pooled across years did not differ from 50:50. Sex ratio in the herd changed mostly as a result of removals. The average age of both males and females in the herd increased during the course of the study. Annual survival of males did not differ from that of females, nor did gender affect annual survival of foals. Pooled across years, ages, and sexes, the annual survival rate was 0.899. Annual foal survival rate was 0.697 and declined through time, with a tendency toward recovery in 2005-2007. Foal survival was higher in larger bands, but did not differ between foals born to primiparous and multiparous mares. A few 2-year-old mares produced foals; foaling rate (excluding contracepted mares and foals they produced) increased through age 10, remained high through age 15, and declined thereafter. Overall foaling rate for mares =3 years of age was 0.576 foals per mare, with no apparent trend during the period of our study. Foaling rate in years following gathers was somewhat lower than in other years. There was a positive relation between foaling rate and band size. Primiparous mares were somewhat less likely to foal in the following year than were multiparous mares. Most stallions that acquired a harem did so at age 5 or 6, and the average age of harem stallions increased during our study. Most harems had 1-3 mares =2 years of age, but harem size varied with age of the stallion, increasing through about age 11 and declining thereafter. About 6 percent of bands had a satellite stallion (=5 years of age), but the mean number of mares did not differ between single- and multistallion bands. Most stallions left their natal band at age 2 or 3, but 17 percent remained with their natal band until age 4 or 5. Foal survival rate was positively related to precipitation, suggesting a possible link to forage production and availability mediated through mare fitness. There also was evidence for density-dependent population regulation, as both population growth rate and survival rate were negatively correlated with population size from the previous year. These and other factors were not sufficient to stabilize the population during our period of study, however, as evidenced by the necess

Effects of exercise on biomechanical properties of the superficial digital flexor tendon in foals.

PubMed

Cherdchutham, W; Meershoek, L S; van Weeren, P R; Barneveld, A

2001-12-01

To determine the effects of exercise on biomechanical properties of the superficial digital flexor tendon (SDFT) in foals. 43 Dutch Warmblood foals. From 1 week until 5 months of age, 14 foals were housed in stalls and not exercised, 14 foals were housed in stalls and exercised daily, and 15 foals were maintained at pasture. Eight foals in each group were euthanatized at 5 months, and remaining foals were housed together in a stall and paddock until euthanatized at 11 months. After euthanasia, SDFT were isolated and fit in a material testing system. Mean cross-sectional area (CSA) was measured and traction forces recorded. Normalized force at rupture (force(rup)), normalized force at 4% strain, strain at rupture, stress at 4% strain (stress(4%stain)), and stress at rupture were compared among and within groups. At 5 months, mean CSA and normalized force(rup) were significantly greater and stress(4%strain) significantly less in the pastured group, compared with the other groups. At 11 months, CSA and normalized force(rup) were not significantly different among groups, because force(rup) increased significantly from 5 to 11 months in the nonexercised group and decreased significantly in the pastured group. Exercise significantly affected the biomechanical properties of the SDFT in foals. Evenly distributed moderate- and low-intensity exercise at a young age may be more effective for development of strong, flexible tendons in horses than single episodes of high-intensity exercise superimposed on stall rest. This effect may impact later susceptibility to SDFT injury.

Foal Fractures: Osteochondral Fragmentation, Proximal Sesamoid Bone Fractures/Sesamoiditis, and Distal Phalanx Fractures.

PubMed

Reesink, Heidi L

2017-08-01

Foals are susceptible to many of the same types of fractures as adult horses, often secondary to external sources of trauma. In addition, some types of fractures are specific to foals and occur routinely in horses under 1 year of age. These foal-specific fractures may be due to the unique musculoskeletal properties of the developing animal and may present with distinct clinical signs. Treatment plans and prognoses are tailored specifically to young animals. Common fractures not affecting the long bones in foals are discussed in this article, including osteochondral fragmentation, proximal sesamoid bone fractures/sesamoiditis, and distal phalanx fractures. Copyright © 2017 Elsevier Inc. All rights reserved.

Diagnosis and Treatment Considerations for Nonphyseal Long Bone Fractures in the Foal.

PubMed

Glass, Kati; Watts, Ashlee E

2017-08-01

Many long bone fractures that are not considered repairable in the adult horse are repairable in the foal. This is largely because of reduced patient size and more rapid healing in the foal. When there is no articular communication, the long-term prognosis for athletic function can be very good. Emergency care and transport of the foal with a long bone fracture is different than the adult. Copyright © 2017 Elsevier Inc. All rights reserved.

Factors affecting pregnancy length and phases of parturition in Martina Franca jennies.

PubMed

Carluccio, Augusto; Gloria, Alessia; Veronesi, Maria Cristina; De Amicis, Ippolito; Noto, Federico; Contri, Alberto

2015-09-01

The knowledge of normal pregnancy length, duration of parturition stages, and neonatal early adaptation is mandatory for a rationale management of birth, especially in monotocous species with long gestations. This study reports data obtained from a large number of Martina Franca jennies with normal healthy pregnancies and spontaneous eutocic delivery of a mature, healthy, and viable donkey foal. Pregnancy lasts, on average, 371 days, and only the fetal gender significantly determines pregnancy length, with longer gestations observed in jennies bearing male fetuses. Other factors such as the year of foaling, month of ovulation, month of parturition, birth weight of the foal, and age of the jenny did not influence pregnancy length. The first stage of foaling lasted on average 65 minutes, the second stage 19 minutes, and the third stage 58 minutes. The umbilical cord ruptured on average within 16 minutes after birth; the foal stood up in 61 minutes and suckled the colostrum for the first time within 10 minutes after birth and again after 143 minutes of birth; meconium passage occurred, on average, 86 minutes after birth. Although times reported for the process of foaling are similar to data reported for the horse, the times for early neonatal donkey foal adaptation are longer as compared to the horse foal. Copyright © 2015 Elsevier Inc. All rights reserved.

Strongylus vulgaris in the tunica media of arteries of ponies and treatment with ivermectin.

PubMed

Slocombe, J O; McCraw, B M; Pennock, P W; Ducharme, N; Baird, J D

1987-04-01

A preliminary investigation was made into the effect of fourth-stage Strongylus vulgaris larvae sequestered in the tunica media of ileocolic arteries of pony foals treated with ivermectin. The foals had been reared parasite-free, inoculated with infective larvae and given orally a placebo or ivermectin paste. Two foals received subsequently one or two further inoculations with larvae and treatment with ivermectin. Arteriography was used to identify the lesions in the ileocolic artery following inoculation and their regression following treatment. At necropsy, foals were examined for lesions and larvae grossly and histologically. Ivermectin was highly effective against fourth-stage larvae and those present in the media appeared not to unduly affect the integrity of the ileocolic artery. Increased numbers of larvae were not found in the media of foals receiving repeat inoculations and repeat treatments. Larvae were not found in the media of foals treated with a placebo. The major pathological changes in the arterial wall of all foals were attributed to infection with S. vulgaris and there was no strong tendency for the damaged arteries to return to normal after the S. vulgaris were removed.

Strongylus vulgaris in the tunica media of arteries of ponies and treatment with ivermectin.

PubMed Central

Slocombe, J O; McCraw, B M; Pennock, P W; Ducharme, N; Baird, J D

1987-01-01

A preliminary investigation was made into the effect of fourth-stage Strongylus vulgaris larvae sequestered in the tunica media of ileocolic arteries of pony foals treated with ivermectin. The foals had been reared parasite-free, inoculated with infective larvae and given orally a placebo or ivermectin paste. Two foals received subsequently one or two further inoculations with larvae and treatment with ivermectin. Arteriography was used to identify the lesions in the ileocolic artery following inoculation and their regression following treatment. At necropsy, foals were examined for lesions and larvae grossly and histologically. Ivermectin was highly effective against fourth-stage larvae and those present in the media appeared not to unduly affect the integrity of the ileocolic artery. Increased numbers of larvae were not found in the media of foals receiving repeat inoculations and repeat treatments. Larvae were not found in the media of foals treated with a placebo. The major pathological changes in the arterial wall of all foals were attributed to infection with S. vulgaris and there was no strong tendency for the damaged arteries to return to normal after the S. vulgaris were removed. Images Fig. 1. Fig. 2. Fig. 3. Fig. 4. Fig. 5. PMID:3607653

KSC-04PD-0020

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- From the KSC television studio, KSC management and other employees applaud President George W. Bush, who addressed the public and an assembly of government officials at NASA Headquarters as he outlined a new focus and vision for the space agency. Shown from left are Mike Leinbach, Shuttle launch director; David Culp, with NASA; Steve Francois, director, Launch Services Program; Richard Cota, deputy chief financial officer, KSC; Bill Pickavance vice president and associate program manager of Florida Operations, United Space Alliance (USA) ; Howard DeCastro, vice president and Space Shuttle program manager, USA; Shannon Roberts, with External Affairs; Woodrow Whitlow, KSC deputy director; Bruce Buckingham, assistant to Dr. Whitlow; Lisa Malone, director of External Affairs; Ken Aguilar, chief, Equal Opportunity office; and Cheryl Cox, External Affairs. The President stated his goals for NASAs new mission: Completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean OKeefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan

STS-86 Crew Lunch in O&C Building

NASA Technical Reports Server (NTRS)

1997-01-01

As part of the final STS-86 prelaunch activities, the seven crew members gather for a snack and a photo opportunity in the Operations and Checkout Building. From left, are Mission Specialist Wendy B. Lawrence, Pilot Michael J. Bloomfield, Mission Specialist Scott E. Parazynski, Commander James D. Wetherbee, Mission Specialist David A. Wolf, Mission Specialist Jean-Loup J.M. Chretien of the French Space Agency, CNES, and Mission Specialist Vladimir Georgievich Titov of the Russian Space Agency. After a weather briefing, the astronauts will don their orange launch and entry suits and depart for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff at about 10:34 p.m. EDT, Sept. 25. The exact launch time may vary slightly based on calculations of the Russian Space Station Mirs precise location in space at the time of liftoff. STS-86 is slated to be the seventh of nine planned dockings of the Shuttle with the Mir. Wolf is scheduled to become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who will return to Earth aboard Atlantis after more than four months on the Russian orbiting outpost.

The occurrence and genetic characterization of Cryptosporidium and Giardia species in foals in Belgium, The Netherlands, Germany and Greece.

PubMed

Kostopoulou, D; Casaert, S; Tzanidakis, N; van Doorn, D; Demeler, J; von Samson-Himmelstjerna, G; Saratsis, A; Voutzourakis, N; Ehsan, A; Doornaert, T; Looijen, M; De Wilde, N; Sotiraki, S; Claerebout, E; Geurden, T

2015-07-30

Faecal samples were collected from foals between the age of 1 week and 6 months in Belgium, The Netherlands, Germany and Greece. A quantitative direct immunofluorescence assay based on the commercial MERIFLUOR Cryptosporidium/Giardia kit was performed to evaluate the presence of (oo) cysts. Parasite positive samples were genotyped, based on the 18S ribosomal DNA gene and the heat shock protein (HSP70) gene for Cryptosporidium and on the β-giardin gene and the triose phosphate isomerase (TPI) gene for Giardia. In total, 134 foals from Belgium, 44 foals from The Netherlands, 30 foals from Germany and 190 foals from Greece were examined. No Cryptosporidium oocysts were identified in faecal samples from foals in Germany and The Netherlands. In Belgium and Greece, 4.5% and 1.1% of the foals examined were Cryptosporidium positive, respectively, all with a low oocyst excretion ranging from 100 to 2450 oocysts per gram of faeces. For Giardia, 14.2%, 11.4%, 10.0% and 11.6% of the foals in Belgium, The Netherlands, Germany and Greece, respectively, were found to excrete cysts, with a range of 50 up to 4,000,000 cysts per gram of faeces. Younger animals secreted significantly more Giardia cysts than older horses (p<0.05), but no significant correlation between Giardia infection and diarrhoea was observed. Most Giardia positive samples belonged to assemblage AI and/or BIV, but also assemblage E was detected in two samples. Together with the identification of Cryptosporidium horse genotype, this suggests only a low risk for zoonotic transmission. Copyright © 2015 Elsevier B.V. All rights reserved.

The protective effects of sucralfate and ranitidine in foals experimentally intoxicated with phenylbutazone.

PubMed Central

Geor, R J; Petrie, L; Papich, M G; Rousseaux, C

1989-01-01

The effects of sucralfate and ranitidine on the gastrointestinal manifestations of phenylbutazone (PBZ) toxicity in horse foals were determined by complete blood count, serum chemistry profile, and gross and histological necropsy examinations. Twenty-eight, three to four month old Belgian-cross foals were randomly assigned to one of four groups. Phenylbutazone was administered at a dosage of 10 mg/kg of bodyweight (BW) per day, intravenously (IV), in equally divided doses to three of the groups. In addition to PBZ, ranitidine was administered at 2 mg/kg BW, IV, twice daily, to one group of seven foals (PBZ/ranitidine group), and sucralfate was administered at 4 g, orally, twice daily to another group of seven foals (PBZ/sucralfate group). A fourth group received normal saline IV and corn syrup orally, twice daily, as placebos (control group). Treatments were administered for ten days. Clinical signs included oral ulceration (in all PBZ-treated foals) and diarrhea (5/7 and 2/7 foals from the PBZ and PBZ/ranitidine groups, respectively). A reduction in total protein and albumin was greatest in the PBZ group and least in the PBZ/ranitidine and PBZ/sucralfate groups when compared to the control group. The PBZ group lost weight during the treatment period. At necropsy, the PBZ group had the greatest area of oral ulceration compared to the other treatment groups. All foals treated with PBZ had gastric ulcers; however, the PBZ group had the most severe gastric epithelial necrosis compared to the other three treatment groups. Duodenal villous atrophy, epithelial necrosis and mucosal inflammation, and a reduction in epithelial mitotic figures were seen in all PBZ-treated foals.(ABSTRACT TRUNCATED AT 250 WORDS) Images Fig. 1. Fig. 2. PMID:2713788

PRESIDENTIAL COMMISSION - STS-33/51L - KSC

NASA Image and Video Library

1986-03-07

S86-28889 (14 Feb. 1986) --- Kennedy Space Center Director Richard Smith points out a portion of a solid rocket booster segment to astronaut Sally Ride and to the chairman of the Presidential Commission on the Space Shuttle Challenger Accident, William P. Rogers. The commission was taken to various booster storage and handling facilities at KSC on Feb. 14, 1986 as part of the failure investigation. Photo credit: NASA

EVA 3 activity on Flight Day 6 to service the Hubble Space Telescope

NASA Image and Video Library

1997-02-16

S82-E-5572 (16 Feb. 1997) --- Pausing near the foot-restraint of the Remote Manipulator System (RMS), astronauts Steven L. Smith (left) and Mark C. Lee communicate with and look toward their in-cabin team members during the third Extravehicular Activity (EVA) to perform servicing chores on the Hubble Space Telescope (HST). This view was taken with an Electronic Still Camera (ESC).

Failure of colostral immunoglobulin transfer as an explanation for most infections and deaths of neonatal foals.

PubMed

McGuire, T C; Crawford, T B; Hallowell, A L; Macomber, L E

1977-06-01

Failure in colostral immunoglobulin G (IgG) transfer was found in 9 of 87 Thoroughbred foals. Seven (78%) of these 9 foals acquired infections requiring therapy. Twelve of the foals had partial failure in colostral IgG transfer, and 3 of these had infections requiring therapy. The remaining 66 foals had normal transfer of colostral IgG, and only 2 had detectable infections. The failure of colostral IgG transfer was attributable to nursing problems in only one case. When presuckle postpartum colostrum was collected, 2 of 4 failures of colostral IgG transfer and 4 of 6 partial failures of colostral IgG transfer were explained by low colostral IgG content. Of 11 foals from various other sources and dying of infection before 2 weeks of age, 6 had failure of colostral IgG transfer (less than 200 mg IgG/100 ml serum), and 4 had partial failure (200-400 mg IgG/100 ml serum).

Martina Franca donkey meat quality: Influence of slaughter age and suckling technique.

PubMed

De Palo, P; Tateo, A; Maggiolino, A; Marino, R; Ceci, E; Nisi, A; Lorenzo, J M

2017-12-01

This work aimed to evaluate the effect of suckling technique and slaughter age on Martina Franca donkey meat quality. Twenty Martina Franca male foals were involved in the trial. Foals naturally assumed colostrum within 4h from birth. Afterwards, 10 foals were partially artificially suckled (AS), and 10 foals were naturally suckled (NS). All the foals were weaned at 180d, then housed indoors and fed the same diet. Ten donkeys were slaughtered at 12months and the other 10 at the age of 18months. Samples of Longissimus thoracis et lumborum (LTL) were taken from each foal for chemical analysis, then rheological parameters, oxidative profile, colorimetric parameters and fatty acid profile were assessed. Older donkeys (18months) fed with natural milk presented the highest intramuscular fat (IMF) and meat protein content. From a dietary view point, IMF acid composition showed a more favourable profile in meat from artificially-reared donkeys compared to naturally-suckled ones. Copyright © 2017 Elsevier Ltd. All rights reserved.

Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans.

PubMed

Olstad, K; Hendrickson, E H S; Carlson, C S; Ekman, S; Dolvik, N I

2013-05-01

To transect blood vessels within epiphyseal cartilage canals and observe whether this resulted in ischaemic chondronecrosis, an associated focal delay in enchondral ossification [osteochondrosis (OC)] and pathological cartilage fracture [osteochondrosis dissecans (OCD)] in the distal femur of foals, with potential translational value to the pathogenesis of juvenile osteochondritis dissecans (JOCD) in children. Ten Norwegian Fjord Pony foals were operated at the age of 13-15 days. Two vessels supplying the epiphyseal growth cartilage of the lateral trochlear ridge of the left distal femur were transected in each foal. Follow-up examination was carried out from 1 to 49 days post-operatively and included plain radiography, macroscopic and histological examination. Transection of blood vessels within epiphyseal cartilage canals resulted in necrosis of vessels and chondrocytes, i.e., ischaemic chondronecrosis, in foals. Areas of ischaemic chondronecrosis were associated with a focal delay in enchondral ossification (OC) in foals examined 21 days or more after transection, and pathological cartilage fracture (OCD) in one foal examined 42 days after transection. The ischaemic hypothesis for the pathogenesis of OC has been reproduced experimentally in foals. There are several similarities between OCD in animals and JOCD in children. It should be investigated whether JOCD also occurs due to a focal failure in the cartilage canal blood supply, followed by ischaemic chondronecrosis. Copyright © 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Hospital treatment as a foal does not adversely affect future sales performance in Thoroughbred horses.

PubMed

Corley, K T T; Corley, M M B

2012-02-01

Many Thoroughbred foals are intended to be sold at public auction. The impact of disease conditions necessitating hospital treatment as a foal on future sales performance is unknown. To determine whether Thoroughbred horses that were treated in a hospital before age 125 days and presented to public auction sell for a different mean price than controls. Foals aged < 125 days, treated at a hospital in Ireland in 2007 or 2008 and presented for sale to a public auction recorded on a publicly accessible database were selected for inclusion in the study. The sales outcome of these subjects was compared to that of 6 controls for each subject, consisting of the 3 horses that were presented to the same sale immediately before and immediately after the subject. Results were controlled for the sale at which the animal presented and the sex of the subject and controls. Sixty-three subjects were presented to public auction: 19 at the foal sales, 39 at the yearling sales and 5 at the 2-year-old sales. Forty-five subjects were sold. There was no difference in the mean sales price (subjects Euros 38,207; controls Euros 35,026) or percentage of animals sold (subjects 71.4%; controls 66.4%) between subjects and controls. If Thoroughbred horses are presented for public auction following hospital treatment as a foal, there is no impact on sales outcome. This information may help commercial breeders of Thoroughbred foals make informed decisions about treatment of their foals.

Successful induction of lactation in a barren Thoroughbred mare: growth of a foal raised on induced lactation and the corresponding maternal hormone profiles.

PubMed

Korosue, Kenji; Murase, Harutaka; Sato, Fumio; Ishimaru, Mutsuki; Harada, Takehiro; Watanabe, Gen; Taya, Kazuyoshi; Nambo, Yasuo

2012-08-01

The purpose of this study was to demonstrate that a barren parous Thoroughbred mare with lactation induced by hormonal treatment can be introduced to an orphan foal at the same farm and that the mare can become pregnant after the end of the hormonal treatment. An additional purpose was to investigate the changes in the plasma concentrations of prolactin, estradiol-17β, progesterone, follicle-stimulating hormone, and luteinizing hormone before, during, and after hormonal treatment. The difference in body weight between the adopted foal and the control foals, which were at the same farm and raised by their natural mothers, was 17 kg at 24 weeks old, when the foals were weaned. However, the adopted foal and the control foals had almost the same weight at 35 weeks old and later. The first ovulation after hormonal treatment was confirmed 10 days after the end of hormonal treatment and then the normal estrous cycle resumed. Furthermore, the changes in plasma progesterone, estradiol-17β, follicle-stimulating hormone, and luteinizing hormone showed regular patterns after the first ovulation. Conception was confirmed in the fifth ovulation. Meanwhile, another study demonstrated that conception was confirmed in the first ovulation after hormonal treatment. The present study is the first to demonstrate the hormonal profiles during and after induction of lactation in a Thoroughbred mare. This approach is useful for solving the economic and epidemic problems of introducing a nurse mare to an orphan foal.

Comparative pharmacokinetics of minocycline in foals and adult horses.

PubMed

Giguère, S; Burton, A J; Berghaus, L J; Haspel, A D

2017-08-01

The objective of this study was to compare the pharmacokinetics of minocycline in foals vs. adult horses. Minocycline was administered to six healthy 6- to 9-week-old foals and six adult horses at a dose of 4 mg/kg intragastrically (IG) and 2 mg/kg intravenously (i.v.) in a cross-over design. Five additional oral doses were administered at 12-h intervals in foals. A microbiologic assay was used to measure minocycline concentration in plasma, urine, synovial fluid, and cerebrospinal fluid (CSF). Liquid chromatography-tandem mass spectrometry was used to measure minocycline concentrations in pulmonary epithelial lining fluid (PELF) and bronchoalveolar (BAL) cells. After i.v. administration to foals, minocycline had a mean (±SD) elimination half-life of 8.5 ± 2.1 h, a systemic clearance of 113.3 ± 26.1 mL/h/kg, and an apparent volume of distribution of 1.24 ± 0.19 L/kg. Pharmacokinetic variables determined after i.v. administration to adult horses were not significantly different from those determined in foals. Bioavailability was significantly higher in foals (57.8 ± 19.3%) than in adult horses (32.0 ± 18.0%). Minocycline concentrations in PELF were higher than in other body fluids. Oral minocycline dosed at 4 mg/kg every 12 h might be adequate for the treatment of susceptible bacterial infections in foals. © 2016 John Wiley & Sons Ltd.

Update on bacterial pneumonia in the foal and weanling.

PubMed

Reuss, Sarah M; Cohen, Noah D

2015-04-01

Bacterial pneumonia is a common cause of disease in both neonatal and weanling foals. The causal organism or organisms differ with the age of the foal, should be identified via microbiologic culture, and will ultimately dictate appropriate treatment. Initial treatment in neonates should be broad spectrum and bactericidal, whereas weanling age foals may receive more targeted treatment. The combination of a macrolide antibiotic and rifampin remains the gold standard for treatment of Rhodococcus equi pneumonia; however, resistance to these antimicrobials is a concern. Copyright © 2015 Elsevier Inc. All rights reserved.

Maternal and neonatal evaluation of derivated reactive oxygen metabolites (d-ROMs) and biological antioxidant potential in the horse.

PubMed

Sgorbini, M; Bonelli, F; Marmorini, P; Biagi, G; Corazza, M; Pasquini, A

2015-01-01

The aim of the present work was to evaluate derivated reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) in mares and foals to study perinatal oxidative status. A total of 60 animals were included in the present study. Maternal and foal venous blood samples were collected immediately after delivery along with a sample drawn from one of the umbilical arteries, and plasma samples were evaluated for lactatemia, d-ROMs, and BAP. The t test for unpaired data was applied between mares versus umbilical artery blood versus foals, both for d-ROMs and BAP. The Pearson test with two-tailed P value and a confidence interval of 95% was performed between d-ROMs and BAP and between d-ROMs and lactatemia, both for mares and foals. Finally, the t test for unpaired data was performed between fillies and colts. The t test showed differences between mares versus their own foals versus umbilical artery blood but not foals versus. umbilical artery blood, both for d-ROMs and BAP. A positive correlation was found both in mares and foals between BAP and d-ROMs and in mares between lactatemia and d-ROM. No differences in gender were found in BAP concentration. Our data are in line to previous studies performed in women and cattle.

Evaluation of parasiticidal activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (Parascaris equorum) in field studies on five farms in Central Kentucky in 2007.

PubMed

Lyons, E T; Tolliver, S C; Ionita, M; Collins, S S

2008-07-01

Horse foals on five farms in Central Kentucky were used in field studies in 2007 evaluating activity of paste formulations of four compounds (fenbendazole-FBZ, ivermectin-IVM, oxibendazole-OBZ, and pyrantel pamoate-PRT) against internal parasites with emphasis on ascarids (Parascaris equorum). It has been well established the last few years that there is widespread resistance of P. equorum to ivermectin. The main purpose of the present research was to obtain current data on ascaridicidal activity of FBZ, OBZ, and PRT; also, to acquire further information on ascarid resistance to ivermectin. Additionally, data were documented on drug activity on small strongyles. Detection of ascarid and strongyle eggs in feces of foals was by a qualitative method (presence or absence) or a quantitative method (eggs per gram of feces). Strongyle eggs all were assumed to be from small strongyles. This is based on fecal cultures from horses on one farm and historic records from horses in this area on excellent deworming programs. A girth tape was used to estimate the body weight of each foal so that the appropriate dose rate of each drug could be given. Many of the foals were used in more than one cycle of treatments. Efficacy of the drugs, administered intraorally, was determined by calculating the average percentage reduction (% red.) of the number of foals passing eggs after vs. before treatment: (1) FBZ at 10 mg/kg was tested on four farms; 76 foals were examined, 50 with ascarid eggs (84% red.) and 62 with strongyle eggs (0% red.); (2) IVM at 200 microg/kg was tested on three farms; 58 foals were examined, 18 with ascarid eggs (0% red.) and 48 with strongyle eggs (100% red.); (3) OBZ at 10 mg/kg was tested on three farms; 181 foals were examined, 78 with ascarid eggs (94% red.) and 79 with strongyle eggs (0% red.); (4) PRT was tested on two farms, one farm at 1x (6.6 mg base/kg); 42 were foals examined, 16 with ascarid eggs (0% red.) and 33 with strongyle eggs (12% red.) and one farm at 2x (13.2 mg base/kg); 18 foals were examined, 13 with ascarid eggs (23% red.) and 15 with strongyle eggs (27% red.).

KSC-97PC840

NASA Image and Video Library

1997-05-24

The Space Shuttle orbiter Atlantis glides in for a landing on Runway 33 at KSC’s Shuttle Landing Facility at the conclusion of the nine-day STS-84 mission. It will be the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and Jean-Francois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

No effect of moderate or high concentrate allowance on growth parameters in weanling Warmblood foals fed late-cut haylage as forage.

PubMed

Mack, J K; Remler, H P; Senckenberg, E; Kienzle, E

2014-10-01

Two groups of Warmblood foals from the Bavarian federal stud participated in the study beginning from the age of approximately 6 months. The foals were offered a late 1st cut of haylage, oats and foal starter feed. For 2 months after weaning, group 'R' (15 foals) received an amount of oats to provide a total digestible energy supply meeting the recommendations of the German Society of Nutrition Physiology (GfE), whereas the other group 'A' (16 foals) was offered a higher amount of oats (surplus of approximately 1.3 kg/animal/day). Concentrates were fed individually twice daily; total daily haylage intake of all foals together was recorded. In both groups, individual concentrate intake, body weight (BW), body condition score (BCS) and several growth parameters were documented. Both groups showed an absolutely parallel development of the measured growth parameters and of BW and BCS. BW and BCS increased above the recommendations of GfE and Hois. The amount of concentrates offered was not ingested completely in both groups. The average metabolisable energy (ME) intake from concentrates amounted to 30.3 and 32.1 MJ ME/animal/day (group 'R') and 38.7 and 38.2 MJ ME/animal/day (group 'A') for the 7th and 8th month respectively. The mean haylage intake of all foals together equalled 26.2 MJ ME/animal/day. The parallel development of all documented growth parameters in both groups leads to the assumption that higher concentrate intake must have caused lower intake of haylage and vice versa, thus resulting in an overall comparable energy intake for each foal, independently of energy source. The calculated average daily energy intake for all foals together amounted to 60.5 and 61.4 MJ ME/animal for the 7th and 8th month. The mean crude protein intake in both groups together amounted to 640 and 647 g/animal/day for the 7th and 8th month. Journal of Animal Physiology and Animal Nutrition © 2014 Blackwell Verlag GmbH.

Evaluation of foal production following intracytoplasmic sperm injection and blastocyst culture of oocytes from ovaries collected immediately before euthanasia or after death of mares under field conditions.

PubMed

Hinrichs, Katrin; Choi, Young-Ho; Norris, Jody D; Love, Linda B; Bedford-Guaus, Sylvia J; Hartman, David L; Velez, Isabel C

2012-10-15

To evaluate the efficiency of foal production following intracytoplasmic sperm injection (ICSI) and blastocyst culture of oocytes from mares that died or were euthanized under field conditions. Prospective case series. 16 mares (age, 3 to 19 years) that died or were euthanized for various causes. Ovaries were collected immediately before euthanasia (n = 10) or after death (6). Ovaries were transported to the laboratory for oocyte recovery (15 mares), or oocytes were recovered at a remote location and shipped to the laboratory (1). Oocytes underwent ICSI, and presumptive zygotes were cultured for 7 to 10 days. Blastocysts were shipped to embryo transfer facilities for transcervical transfer to recipient mares. Ovaries were processed 30 minutes to 12 hours (mean ± SD, 4.6 ± 3.3 hours) after mares' deaths. A mean of 14.1 ± 8.6 oocytes/mare were cultured, and 110 of 225 (49%) matured. Twenty-one blastocysts developed after ICSI and were transferred to recipient mares. Thirteen pregnancies were established; 10 healthy foals were produced from 6 donor mares. The number of blastocysts produced per mare and number of live foals produced per mare were significantly correlated with the number of oocytes recovered. Foals were produced from mares after death or euthanasia under field conditions. Proportions of foals born overall (10 foals/16 mares) and mares from which ≥ 1 foal was produced (6/16) were greater than those reported following recovery and oviductal transfer of oocytes to inseminated recipients after death of donor mares under field conditions.

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia.

PubMed

Alanazi, Abdullah D; Mukbel, Rami M; Alyousif, Mohamed S; AlShehri, Zafer S; Alanazi, Ibrahim O; Al-Mohammed, Hamdan I

2017-12-01

In the last decade, Parascaris spp. resistance to anthelmintics has been recorded in many countries. In Saudi Arabia, there are limited data available on Parascaris spp. resistance to anthelmintics. To determine the current status of ivermectin, abamectin and praziquantel combined, and fenbendazole resistance to Parascaris spp. in horses in Saudi Arabia. Three hundred and forty-one foals from eleven different farms were examined by faecal egg count (FEC). The foals were all Arab horses aged 17.2 ± 4.5 (SD) months. Ivermectin (n = 46 foals), abamectin and praziquantel combined (n = 46), and fenbendazole (n = 46) were administered on day 0 and faeces were collected on day 14. The study comprised 41 untreated foals as controls. Animals that have FEC of ≥100 eggs per gram (EPG) were used to measure anthelmintic efficacy. Parascaris spp. populations were considered susceptible when faecal egg count reduction (FECR) was ≥95% associated with a lower 95% confidence limit (LCL) >90%, suspected resistant when FECR ≤90% or LCL <90% and resistant when FECR <90% and LCL <90%. Prevalence of Parascaris spp. infection was 53% (179/341 horses). Anthelmintic resistance to Parascaris spp. were highest following fenbendazole (55% of farms and 65% of foals) and to a lower extent following ivermectin or the combination of abamectin and praziquantel which comprised 27% of farms (and 46% of foals) and 18% of farms (and 10% of foals), respectively. These data indicate that anthelmintics-resistant Parascaris spp. populations are present on horse farms in Saudi Arabia.

STS-103 Discovery crawls to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

Space Shuttle Discovery, atop the mobile launcher platform and crawler transporter, nears the top of Launch Pad 39B after a 4.2-mile crawl from the Vehicle Assembly Building. At left are the Rotating Service Structure and the Fixed Service Structure, which will enable final preparations of the orbiter, external tank and solid rocket boosters for the STS-103 launch targeted for Dec. 6, 1999, at 2:37 a.m. EST. The mission is a 'call-up' due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, both with the European Space Agency.

STS-103 Discovery crawls to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

Space Shuttle Discovery stands poised in the open door of the Vehicle Assembly Building before its 4.2-mile (6.8 kilometer) crawl to Launch Pad 39B atop the mobile launcher platform and crawler transporter. Once at the pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the STS-103 launch targeted for Dec. 6, 1999, at 2:37 a.m. EST. The mission is a 'call-up' due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, both with the European Space Agency.

STS-103 Discovery crawls to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

Space Shuttle Discovery clears the Vehicle Assembly Building (left) on its 4.2-mile (6.8 kilometer) crawl to Launch Pad 39B atop the mobile launcher platform and crawler transporter. Once at the pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the STS-103 launch targeted for Dec. 6, 1999, at 2:37 a.m. EST. The mission is a 'call-up' due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, both with the European Space Agency.

STS-103 Discovery crawls to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

With the American flag flapping in the morning breeze, Space Shuttle Discovery across the turn basin makes its 4.2-mile (6.8 kilometer) crawl to Launch Pad 39B (background, left) atop the mobile launcher platform and crawler transporter. Once at the pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the STS-103 launch targeted for Dec. 6, 1999, at 2:37 a.m. EST. The mission is a 'call-up' due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, both with the European Space Agency.

Effectiveness of oxfendazole against early and later 4th-stage Strongylus vulgaris in ponies.

PubMed

Slocombe, J O; McCraw, B M; Pennock, P; Ducharme, N G; Baird, J D

1986-03-01

Twenty pony foals (reared worm free), 6.5 to 10 weeks of age, were inoculated with Strongylus vulgaris and allocated to 5 groups, each with 4 foals. One week after inoculation, 1 group of 4 foals was given oxfendazole (OFZ) at a dosage rate of 10 mg/kg of body weight, another group was given 2 such treatments 48 hours apart, and a 3rd group was given a placebo. All treatments were administered by stomach tube. Three weeks later, foals were euthanatized and necropsied in a test for efficacy against early 4th-stage larvae. Oxfendazole was 80% and 94.9% effective against early 4th-stage S vulgaris with 1 and 2 doses, respectively. A 4th group of 4 foals was given 2 treatments of OFZ, 48 hours apart, about 8 weeks after inoculation, and a 5th group was given a placebo. These foals were euthanatized and necropsied 5 weeks after treatment in a test for efficacy against later 4th-stage larvae. Two doses of OFZ were 96.6% effective against later 4th-stage larvae.

Effects of dystocia on blood gas parameters, acid-base balance and serum lactate concentration in heavy draft newborn foals.

PubMed

Kimura, Yuki; Aoki, Takahiro; Chiba, Akiko; Nambo, Yasuo

2017-01-01

Dystocia is often lethal for neonatal foals; however, its clinicopathological features remain largely unknown. We investigated the effect of dystocia on the foal blood profile. Venous blood samples were collected from 35 foals (5 Percheron and 30 crossbreds between Percheron, Belgian, and Breton heavy draft horses) at 0 hr, 1 hr, 12 hr and 1 day after birth. Dystocia was defined as prolonged labor >30 min with strong fetal traction with or without fetal displacement. The dystocia group (n=13) showed lower mean values for pH (P<0.01), bicarbonate (P<0.01), total carbon dioxide (P<0.05), and base excess (P<0.01) and higher mean values for anion gap (P<0.05) and lactate (P<0.01) immediately after birth than the normal group (n=22). Remarkably high pCO 2 values (>90 mmHg) were observed in three foals in the dystocia group but in none of the foals in the normal birth group immediately after birth. These results suggest that dystocia results in lactic acidosis and may be related to respiratory distress.

Physicochemical properties of foal meat as affected by cooking methods.

PubMed

Lorenzo, José M; Cittadini, Aurora; Munekata, Paulo E; Domínguez, Rubén

2015-10-01

The present study deals with the effect of four different cooking techniques (roasting, grilling, microwave baking and frying with olive oil) on physicochemical parameters (cooking loss, WHC, texture and colour) and lipid oxidation (by TBARS measurement) of foal meat. Thermal treatments induced water loss (P<0.001), being lower in foal steaks cooked in the grill (25.8%) and higher in foal samples cooked in the microwave (39.5%). As it was expected, all the cooking methods increased TBARS index, since high temperature during cooking seems to cause an increase of the lipid oxidation in foal steaks. Statistical analysis displayed that WHC was affected (P<0.001) by thermal treatment, since the smallest WHC values were observed in samples from microwave treatment. Thermal treatment also caused a significant (P<0.001) increase in the force needed to cut the foal steaks. Regarding colour parameter, cooking led to an increase of L*-value (lightness) and b*-value (yellowness), while a*-value (redness) markedly decreased in all samples. Copyright © 2015 Elsevier Ltd. All rights reserved.

Relationship between carcass traits, prime cuts and carcass grading from foals slaughtered at the age of 13 and 26 months and supplemented with standard and linseed-rich feed.

PubMed

Ruiz, M; Sarriés, M V; Beriain, M J; Crecente, S; Domínguez, R; Lorenzo, J M

2018-05-01

In order to improve foal carcass quality, it is necessary in particular to improve the carcass dressing percentage and tissue composition. Thus, it is important to establish relationships between grading systems and these parameters. This research was conducted to study the effect of slaughter age (13 v. 26 months) and finishing feed (standard v. linseed feed) on carcass characteristics such as subcutaneous fat colour plus classification of foals for the degree of fatness and conformation. For this study, 46 foals of crossbred genotype (Galician Mountain×Burguete) were used. Finishing feed did not affect any parameter, whereas slaughter age influenced all parameters (P<0.05). The oldest foals had higher carcass measurements, 13% more of meat, 4% more of bone, 12% more of fat, and 4% and 9% bigger fore- and hindquarter, respectively. Consequently, bigger valuable prime cuts were obtained. Nevertheless, the meat : bone ratio was very similar for both 13- and 26-month-old foals (2.88). Most of 26-month-old foals were classified in 'E' (Extra) and '5' (Complete fat cover) categories of conformation and degree of fatness. Most of the carcasses showed subcutaneous fat described as yellowish-white irrespective of age or diet. A regression model found that conformation (36%) and degree of fatness (33%) in live animals was positively linked with carcass tissue composition. It is therefore suggested that producers aim for older slaughter ages than 13 months and that the foal meat industry establishes grading systems to predict carcass quality. Further studies should be necessary to find the optimal slaughter age to obtain carcasses in the best categories of degree of fatness and conformation. New studies should be recommended to improve the meat : bone ratio of foal carcasses as it estimates the aptitude for meat production.

Evaluation of behaviour in stabled draught horse foals fed diets with two protein levels.

PubMed

Sartori, C; Guzzo, N; Normando, S; Bailoni, L; Mantovani, R

2017-01-01

The present work is aimed at evaluating the behaviour of Italian Heavy Draught Horse (IHDH) foals reared in semi-covered stables and fed two isoenergetic total mixed rations with different dietary protein levels (13.2% and 10.6% of CP on dry matter). The study was prompted by the restrictions for nitrate emissions in farms of the European Nitrate Directive. One suggested solution is to reduce dietary protein while maintaining normal performance and welfare, but there is a lack of literature in studies of horses. The behaviours of 20 foals of 437±60 kg of BW, aged 379±37 days and stabled in four pens by sex (S) and diet (D) were video recorded and analysed to build a suitable ethogram including 18 behaviours in six categories: ingestion, resting, maintenance, movement, social activities, other. The percentage of the daily time spent in each behavioural category and single behaviours was analysed via a single traits GLM including S, D and their interaction. Daily activity was consistent with existing literature: foals spent about 33% of the day in ingestion activities and 41% in resting, whereas social interactions constituted 8% of the time and individual maintenance <2%. Concerning diet, foals fed high protein spent more time in movement (19.62±0.73% of day v. 10.45±0.73% in low-protein (LP) foals; P⩽0.001), whereas the LP group increased resting (43.42±1.12% v. 38.02±1.12%; P⩽0.001). No stereotypies were found, and daily activity followed the typical values for draught breeds for foals in both dietary groups, a result that suggests the maintenance of well-being after dietary protein reduction. This result, together with the findings of a companion study showing no changes in growth performances of foals, showed that a reduction of CP in foal diet is reconcilable with the maintenance of performance and welfare.

The effect of livestock production system and concentrate level on carcass traits and meat quality of foals slaughtered at 18 months of age.

PubMed

Lorenzo, J M; Crecente, S; Franco, D; Sarriés, M V; Gómez, M

2014-03-01

This trial was conducted to study the effect of livestock production system (freedom extensive system (FES) v. semi extensive system (SES)) and amount of finishing feed (1.5 v. 3.0 kg of commercial feed) in SES on carcass characteristics, meat quality and nutritional value of meat foal slaughtered at 18 months of age. For this study, a total of 49 foals (21 from FES and 28 from SES) were used. The obtained results showed that SES had a positive influence on carcass characteristic because these foals showed the best values for live weight, carcass weight, dressing percentage, perimeter of leg (PL) and carcass compactness index. On the other hand, finishing feeding also had a significant (P<0.05) effect on PL and lean thickness, as the highest values were obtained in foals finished with 3 kg of commercial fodder. The physico-chemical properties were significantly affected by the livestock production system with the exception of ashes content (P>0.05). Foals finished in SES increased in 408% the intramuscular fat content (0.23 v. 1.17%, for foals reared in FES and SES, respectively). On the other hand, L*-value and a*-value were significantly (P<0.01) affected by livestock production system, as foals from the FES group had a more intense redder color (higher CIE a*-value) and higher lightness (higher CIE L*-value) compared with those from the SES group. Finally, meat nutritional value was significantly affected by livestock production system, as foals from an extensive production system on wood pasture could be considered as healthier in relation to their fatty acid profiles (low n-6/n-3 ratio and high hypocholesterolemic/hypercholesterolemic ratio) as a result of the beneficial grass intake on meat fatty acid profile.

KSC-97pc655

NASA Image and Video Library

1997-04-16

An oxygen generator destined to replace a malfunctioning unit on the Russian Mir Space Station is the object of much curiosity during preflight preparations in the SPACEHAB Payload Processing Facility. A SPACEHAB Double Module on the Space Shuttle Atlantis will carry the oxygen generator to Mir during STS-84, the sixth Shuttle-Mir docking. The nearly 300-pound generator, manufactured by RSC Energia in Russia, will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff

STS-84 Day 03 Highlights

NASA Technical Reports Server (NTRS)

1995-01-01

On this third day of the STS-84 mission, the flight crew, Cmdr. Charles J. Precourt, Pilot Eileen M. Collins, Payload Cmdr, Jean-Francois Clervoy (ESA), Mission Specialists Edward T. Lu, Carlos I. Noriega, Elena V. Kondakova, Jerry M. Linenger (download), and C. Michael Foale (upload) guide Atlantis to its docking with the Mir to cap off a 42-hour chase. Precourt greets Mir 23 Commander Vasily Tsibliev and, after embraces and handshakes, the crew members make their way into the Mir Core Module for a brief welcoming ceremony. During the ceremony, the Shuttle crew give Tsibliev and Flight Engineer Alexander Lazutkin baseball caps emblazoned with the STS-84 crew insignia as well as the traditional Russian offering of bread, tea and salt. Then, the ten astronauts and cosmonauts get down to business, first conducting a joint safety briefing to familiarize themselves with each other's craft.

Infection of internal umbilical remnant in foals by Clostridium sordellii.

PubMed

Ortega, J; Daft, B; Assis, R A; Kinde, H; Anthenill, L; Odani, J; Uzal, F A

2007-05-01

Omphalitis and the resulting septicemia contribute to perinatal mortality in several animal species. In foals, the most important causes of omphalitis are Escherichia coli and Streptococcus zooepidemicus. However to date, no information has been published about the role of Clostridium sordellii in these infections. In this paper, we describe 8 cases of perinatal mortality in foals associated with internal umbilical remnant infection by C. sordellii. The foals studied were between 12 and 21 days old at the time of death, and various breeds were represented in the group. Five of the foals were male and 3 were female. The diagnosis was established on the basis of the detection of C. sordellii by 3 methods (culture, fluorescent antibody test, and immunohistochemistry) and on gross and histopathologic findings. All foals had acute peritonitis, and the internal umbilical remnant was thickened by edema, hemorrhage, and fibrosis. A moderate amount of serosanguinous fluid with fibrin strands was present in the pericardial sac and pleural cavity. Histopathologically, the urachus and umbilical arterial walls were thickened by edema and exhibited hemorrhage, fibrin, and leukocytic infiltration. Gram-positive bacterial rods were observed in subepithelial areas of the urachus, the adventicia of umbilical arteries, and interstitium of the internal umbilical remnant. On the basis of these findings, we suggest that C. sordellii should be considered in the differential diagnosis for infections of the internal umbilical remnant in foals.

Cholangiohepatitis and pancreatitis secondary to severe gastroduodenal ulceration in a foal

PubMed Central

Buote, Melanie

2003-01-01

A 2-month-old foal was presented with clinical signs of colic. Gastroduodenal ulceration was suspected. A poor response to medical treatment and signs of gastroduodenal obstruction led to celiotomy and an attempted bypass procedure. The foal was euthanized and postmortem examination revealed gastric ulceration, segmental duodenal stenosis, and severe chronic cholangiohepatitis and pancreatitis. PMID:14524632

Role of the 85-Kilobase Plasmid and Plasmid-Encoded Virulence-Associated Protein A in Intracellular Survival and Virulence of Rhodococcus equi

PubMed Central

Giguère, Steeve; Hondalus, Mary K.; Yager, Julie A.; Darrah, Patricia; Mosser, David M.; Prescott, John F.

1999-01-01

Rhodococcus equi is a facultative intracellular pathogen of macrophages and a cause of pneumonia in young horses (foals) and immunocompromised people. Isolates of R. equi from pneumonic foals typically contain large, 85- or 90-kb plasmids encoding a highly immunogenic virulence-associated protein (VapA). The objective of this study was to determine the role of the 85-kb plasmid and VapA in the intracellular survival and virulence of R. equi. Clinical isolates containing the plasmid and expressing VapA efficiently replicated within mouse macrophages in vitro, while plasmid-cured derivatives of these organisms did not multiply intracellularly. An isolate harboring the large plasmid also replicated in the tissues of experimentally infected mice, whereas its plasmid-cured derivative was rapidly cleared. All foals experimentally infected with a plasmid-containing clinical isolate developed severe bronchopneumonia, whereas the foals infected with its plasmid-cured derivative remained asymptomatic and free of visible lung lesions. By day 14 postinfection, lung bacterial burdens had increased considerably in foals challenged with the plasmid-containing clinical isolate. In contrast, bacteria could no longer be cultured from the lungs of foals challenged with the isogenic plasmid-cured derivative. A recombinant, plasmid-cured derivative expressing wild-type levels of VapA failed to replicate in macrophages and remained avirulent for both mice and foals. These results show that the 85-kb plasmid of R. equi is essential for intracellular replication within macrophages and for development of disease in the native host, the foal. However, expression of VapA alone is not sufficient to restore the virulence phenotype. PMID:10377138

Serological investigation of transplacental infection with Neospora hughesi and Sarcocystis neurona in broodmares.

PubMed

Pusterla, Nicola; Mackie, Sarah; Packham, Andrea; Conrad, Patricia A

2014-12-01

The aim of the present study was to investigate the likelihood of transplacental transmission of Neospora hughesi and Sarcocystis neurona in foals, born from seropositive mares. Three broodmares with persistent N. hughesi infection gave birth to eight healthy foals over a period of 7 years. These foals were seropositive to N. hughesi prior to colostrum ingestion, with titers ranging between 640 and 20,480, measured by indirect fluorescence antibody test (IFAT). Of 174 foals born at another farm to mares with a high seroprevalence to S. neurona, only one (with a pre-colostrum antibody titer of 80) tested seropositive. Transplacental transmission of N. hughesi seems to occur from latently infected mares to their foals, while this route of transmission does not seem to occur commonly for S. neurona. Copyright © 2014 Elsevier Ltd. All rights reserved.

An infanticide attempt by a free-roaming feral stallion (Equus caballus)

PubMed Central

Gray, Meeghan E.

2008-01-01

Infanticide by adult males occurs in a variety of species. While infanticidal attacks have been documented in several equid species in captivity, it has never been witnessed in free-roaming feral horses. I report an infanticide attempt by a free-living feral stallion on a recently born female foal. The stallion picked up the foal by the shoulders, tossed it around twice and bit in on the neck several times. The dam of the foal charged the stallion and successfully protected her foal from additional attacks. The foal survived the attack and later weaned successfully. The stallion recently took over the band and was excluded as the sire through genetic analysis. While this type of attack is rare, this case lends support to the sexual selection hypothesis and further demonstrates that equids have evolved with the risk of infanticide. Furthermore, it shows that maternal protectiveness can be successful against attacks by infanticidal males. PMID:19019779

9 CFR 311.28 - Carcasses of young calves, pigs, kids, lambs, and foals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Carcasses of young calves, pigs, kids... PARTS § 311.28 Carcasses of young calves, pigs, kids, lambs, and foals. Carcasses of young calves, pigs, kids, lambs, and foals are unwholesome and shall be condemned if (a) the meat has the appearance of...

9 CFR 311.28 - Carcasses of young calves, pigs, kids, lambs, and foals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Carcasses of young calves, pigs, kids... PARTS § 311.28 Carcasses of young calves, pigs, kids, lambs, and foals. Carcasses of young calves, pigs, kids, lambs, and foals are unwholesome and shall be condemned if (a) the meat has the appearance of...

9 CFR 311.28 - Carcasses of young calves, pigs, kids, lambs, and foals.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Carcasses of young calves, pigs, kids... PARTS § 311.28 Carcasses of young calves, pigs, kids, lambs, and foals. Carcasses of young calves, pigs, kids, lambs, and foals are unwholesome and shall be condemned if (a) the meat has the appearance of...

9 CFR 311.28 - Carcasses of young calves, pigs, kids, lambs, and foals.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Carcasses of young calves, pigs, kids... PARTS § 311.28 Carcasses of young calves, pigs, kids, lambs, and foals. Carcasses of young calves, pigs, kids, lambs, and foals are unwholesome and shall be condemned if (a) the meat has the appearance of...

9 CFR 311.28 - Carcasses of young calves, pigs, kids, lambs, and foals.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Carcasses of young calves, pigs, kids... PARTS § 311.28 Carcasses of young calves, pigs, kids, lambs, and foals. Carcasses of young calves, pigs, kids, lambs, and foals are unwholesome and shall be condemned if (a) the meat has the appearance of...

Effects of imprint training procedure at birth on the reactions of foals at age six months.

PubMed

Williams, J L; Friend, T H; Collins, M N; Toscano, M J; Sisto-Burt, A; Nevill, C H

2003-03-01

While imprint training procedures have been promoted in popular magazines, they have received limited scientific investigation. To determine the effects of a neonatal imprint training procedure on 6-month-old foals and to determine if any one session had a greater effect than others. Foals (n = 131) were divided into the following treatments: no imprint training, imprint training at birth, 12, 24 and 48 h after birth or imprint training only at birth, 12, 24, 48, or 72 h after birth. Foals then received minimal human handling until they were tested at 6 months. During training, time to complete exposure to the stimulus was significant for only 2 of 6 stimuli. Percentage change in baseline heart rate was significant for only 2 of 10 stimuli. These 4 effects were randomly spread across treatments. Neither the number of imprint training sessions (0, 1, or 4) nor the timing of imprint training sessions (none, birth, 12, 24, 48, or 72 h after birth) influenced the foal's behaviour at 6 months of age. In this study, imprint training did not result in better behaved, less reactive foals.

Rupture of the gastrocnemius muscle in six foals.

PubMed

Jesty, Sophy A; Palmer, Jonathan E; Parente, Eric J; Schaer, Thomas P; Wilkins, Pamela A

2005-12-15

Rupture of the gastrocnemius muscle and subsequent disruption of the reciprocal mechanism of the hind limb was diagnosed in 6 foals examined at 7 hours to 3 weeks of age. In 2 foals, the musculoskeletal injury was detected as an ancillary finding to clinical signs of neurologic dysfunction ascribed to hypoxic ischemic insult during delivery, whereas in the other 4 foals, musculoskeletal injury, manifested as inability to rise or stand unsupported, was the chief complaint at admission. Five foals had a history of dystocia and assisted delivery. Common clinical signs were inability to rise, disruption of the reciprocal mechanism, swelling in the caudal aspect of the thigh, instability of the stifle joint, and stifle joint effusion. For mild gastrocnemius injury, exercise restriction via forced recumbency, with minimal or no bandaging, may be sufficient treatment. For more severe disruption of the muscle, limb stabilization via splinting and intensive nursing and monitoring are necessary. Four foals had important concurrent problems, including musculoskeletal deformations (joint contractures), hypoxic ischemic disease, and failure of passive transfer and associated problems (ie, sepsis, polyarthritis, and pneumonia). Moderate to severe gastrocnemius muscle injury is difficult to treat successfully, and the long-term prognosis for athletic function should be regarded as guarded.

Effects of dystocia on blood gas parameters, acid-base balance and serum lactate concentration in heavy draft newborn foals

PubMed Central

KIMURA, Yuki; AOKI, Takahiro; CHIBA, Akiko; NAMBO, Yasuo

2017-01-01

ABSTRACT Dystocia is often lethal for neonatal foals; however, its clinicopathological features remain largely unknown. We investigated the effect of dystocia on the foal blood profile. Venous blood samples were collected from 35 foals (5 Percheron and 30 crossbreds between Percheron, Belgian, and Breton heavy draft horses) at 0 hr, 1 hr, 12 hr and 1 day after birth. Dystocia was defined as prolonged labor >30 min with strong fetal traction with or without fetal displacement. The dystocia group (n=13) showed lower mean values for pH (P<0.01), bicarbonate (P<0.01), total carbon dioxide (P<0.05), and base excess (P<0.01) and higher mean values for anion gap (P<0.05) and lactate (P<0.01) immediately after birth than the normal group (n=22). Remarkably high pCO2 values (>90 mmHg) were observed in three foals in the dystocia group but in none of the foals in the normal birth group immediately after birth. These results suggest that dystocia results in lactic acidosis and may be related to respiratory distress. PMID:28400704

STS 51-L crewmembers during training session in flight deck simulation

NASA Technical Reports Server (NTRS)

1985-01-01

Shuttle mission simulator (SMS) scene of Astronauts Michael J. Smith, Ellison S. Onizuka, Judith A. Resnik, and Francis R. (Dick) Scobee in their launch and entry positions on the flight deck (46207); Left to right, Backup payload specialist Barbara R. Morgan, Teacher in Space Payload specialist Christa McAuliffe, Hughes Payload specialist Gregory B. Jarvis, and Mission Specialist Ronald E. McNair in the middeck portion of the Shuttle Mission Simulator at JSC (46208).

Operation-management factors associated with early-postnatal mortality of US foals.

PubMed

Losinger, W C; Traub-Dargatz, J L; Sampath, R K; Morley, P S

2000-11-16

Of 7320 equine foals reported born alive during 1997 on 1043 operations that had equids on 1 January 1997, and that participated in the United States National Animal Health Monitoring System (NAHMS) Equine 1998 Study, 120 foals were reported to have died (by either euthanasia or natural causes) within the first 2 days of a live birth. The weighted estimate was 1.7% mortality (standard error=0.5) within the first 2 days of live birth for all foals born on operations in the 28 states included in the study.A multivariable logistic-regression model revealed that foals born in the southern region were more likely to have been reported to have died within the first 2 days of live birth than in the western region. In addition, the following operation-level factors were associated with increased odds of a foal dying within the first 2 days of live birth: not routinely testing newborn foals for adequate absorption of colostral immunoglobulins during the first 2 days of life; adding new resident equids to the operation during 1997; having non-resident equids stay on the operation for 1-30 days during 1997; never requiring an official health certificate (for operations that had non-resident equids stay on the operation for 1-30 days); using something other than straw or hay as the predominant bedding type; and feeding equids a vitamin-mineral supplement/premix with forage and/or grain.

Comparative endoscopic evaluation of normal and ulcerated gastric mucosae in Thoroughbred foals

PubMed Central

OKAI, Kazuhiko; TAHARAGUCHI, Sadao; ORITA, Yasuhiro; YOKOTA, Hiroshi; TANIYAMA, Hiroyuki

2015-01-01

To contribute to early diagnosis and treatment of gastric ulcer of foals, we examined the gastric mucosa of healthy and affected foals using an endoscope. In healthy foals, the characteristic changes in the development of the squamous mucosa were seen mainly in the squamous mucosa, and maturation of the squamous mucosa in the greater curvature (GC-S) occurred more slowly than that of the squamous mucosa in the lesser curvature (LC-S). Epithelial desquamation in the LC-S and GC-S was observed between 6 and 90 days but was not observed in the LC-S at about 60 days, whereas it was observed in the GC-S until 90 days old. These findings suggest that there is a difference in the development of the gastric mucosa by region and that desquamation continues over a term longer than studies have reported in the past. In the affected foals, the minimum age at which gastric ulcer was observed was 4 days old. Gastric ulcers formed predominantly in the squamous mucosa (LC-S and GC-S) of foals with an immature mucosa before the weaning period, and the peak incidence occurred between 61 and 90 days old. The differences in the ulceration sites were considered to depend on the difference in the development (maturation) stage of the squamous mucosa. The grading score of the gastric ulcer increased with the growth of the affected foals. The gastric ulcer might be enhanced greatly by stress in the weaning period. PMID:25648790

Ep43 Diet like an Astronaut

NASA Image and Video Library

2018-05-04

Dan Huot (Host): Houston, we have a podcast. Welcome to the official podcast of the NASA Johnson Space Center. This is episode 43, diet like an astronaut. I'm Dan Huot and I'll be your host today. And on this podcast we bring in the experts. NASA scientists. Engineers. Astronauts. Anybody who can let you know about the coolest stuff going on right here at NASA. Today we're talking about nutrition in space. More specifically, what the astronauts have to eat to stay healthy and functional during long-duration space flight. There's a lot of folks working on that right here at the NASA Johnson Space Center. Including my guest Dr. Scott Smith, NASA nutritionist and the manager for nutritional biochemistry. There's some pretty significant differences in the way astronauts have to eat in space versus the way we eat here on Earth. And so we sat down to learn more about what the body needs to thrive in space. And how we're preparing to tackle some big challenges for future long-duration missions into deep space. So with no further delay, let's go light speed and jump right ahead to our talk with Dr. Scott Smith. Enjoy. [ Music ] All right, I'm here with Dr. Scott Smith. Scott, you're the, can I call you Scott? Scott Smith: You can call me Scott. Host: Scott, just for the sake of keeping things easy. So you're the manager, and this is a mouthful as so of our guests are, for nutritional biochemistry. You're a NASA nutritionist. Start me off. What does that mean? What does your job kind of encompass here? Scott Smith: Well, the nutrition biochemistry lab is responsible for, in essence, keeping crews healthy from a nutrition point of view. So we are not the food lab. I'm always very quick to point out we don't make the Tang. I don't have anything to do with the food. Our job is to understand what the body needs. And we provide data to the food lab that crew members need this many calories and this much protein. Or this much carbohydrate. Or this much vitamin A. Or vitamin E. Or vitamin D. Or iron. Copper. Sodium. Zinc. You name it. So we're really the nutrient end of things. And we do work with the crews to make sure they're eating well. And then we try to study the body during flight. In ground analogs to try to understand how we can modify nutrition to help keep crews healthier during space flight. Host: And it kind of amazes me that you go so in depth, you know. You're not, the astronauts aren't just counting calories. You're counting everything for them. And, I mean, is this something we've always been doing with space flight? Scott Smith: Well, nutrition's always been important, first of all. And, no. In many cases on most flights, we've not annoyed the crew with nutrition. Recently, about a year and a half ago, we flew an iPad app to the station that allows the crews to track their dietary intake. And they report literally everything they eat. Every single day, every single meal, they go into the app and enter what foods they ate. Which gives them a real-time look on the iPad of how many calories they're getting. Are they getting enough fluid? Are they getting too much sodium? But as you inferred, we get those data on the ground. And we work that out to 180 different nutrients of, all the way down into the grid. We were looking at iodine data this morning, to give you an idea. And really, when you talk about human health and you talk about what we're trying to do, nutrition becomes very, very important. Host: I mean, especially when they're up there for a really long time I would imagine. [ Multiple Speakers ] Scott Smith: Absolutely, absolutely. And, indeed, on shuttle missions, nutrition was important. But we always looked at nutrition as a camping trip on a shuttle flight. That, you know, you could eat pretty much anything for two weeks and get away with it. When you're up there for a month or three months, six months, it's important. And as we look to go off beyond low Earth orbit at two and three years Mar's missions. If you run out of a nutrient on one of those missions, you're going to be in trouble. Host: And so we talked a little bit before this. And, I mean, this is something people have been paying attention to as long as humans have been exploring; right? I mean, you almost don't think about it. But then there's some pretty real examples that people will remember. Scott Smith: Absolutely. And I don't think they realized it. Much like today, they didn't appreciate nutrition. Host: Yeah. Scott Smith: You know, and I would say that everybody can see we're going to fly food on space missions because you got to fly food. Host: Yeah. Scott Smith: But the idea that we need to pay attention to what's in the food gets lost on a lot of people. And I always say, you know, if you look back through the history books, nutrition in and of itself made or broke many of those exploration missions here on Earth. Host: Like what? Scott Smith: Well, the classic example is always scurvy, vitamin C deficiency. And, you know, if you look at the time span between Columbus' trip and the invention of the steam engine. It's about a 400-year block there. Scurvy killed mover than 2 million sailors. Host: Really? Scott Smith: And it's estimated that scurvy killed more sailors than all other causes of death combined. And there were ships that went out with hundreds that came back with tens. It was that big a deal. Host: And it all came back to what they were eating? Scott Smith: It all came back to what they were eating and what they weren't eating. That they weren't getting any or enough sources of vitamin C. Host: And what did they ultimately do to solve that? I mean, I think we usually heard like starting eat, start carrying oranges and lemons and stuff; right? [ Multiple Speakers ] Scott Smith: Exactly. Scott Smith: The British were called limeys because they used to bring limes on the voyages. Because they realized that it was something in the citrus fruit. It wasn't until the 1900s that they actually isolated and realized what that chemical compound was. But they knew it was in citrus fruit. Host: But, I mean, even back then there were kind of attempts to figure out, okay, you know, my ship is coming back a whole lot lighter than it left. Scott Smith: Indeed. Host: Why the heck is that happening? Scott Smith: And, again, over those 400 years there were advances and setbacks. Even after there was evidence that citrus fruit were the key, there were some captains that insisted that that was not it. That they maintained that fresh meat and clean kitchens, clean galleys was going to solve this. And then went out and found out the hard way that that was not true. And my suspicion is that fresh meat came from the fact that, you know, on those ships, when they had grain and food stored. They'd had rats stowaway on the ship. And they would catch the rats. And some of the crew would eat the rats. And the crews that ate the rats tended to do better. Because rats do not need vitamin C in their diet. Rats can make vitamin C. Host: Really? Scott Smith: So if you ate the rat, it was an analogous to eating an orange. Probably a little chewier. But those crews tended to do better. And it wasn't until they put all that together. Well, I'm not sure they ever put the rat thing together. Host: Yeah. Scott Smith: But, again, that was missing one single nutrient. Host: Yeah. Scott Smith: If we, on a three-year mission, run out of any vitamin, any mineral, it's going to be a bad trip. Host: Well, luckily, we've come a whole lot further in the field of nutritional science since then. Scott Smith: Indeed. Host: So what are, you've been doing this for a while now. What, I mean, so you're doing it with station now. But you mentioned shuttle. What were some of the kind of the early steps that you were taking in this field with space flight? Scott Smith: Well, we use any opportunity we can to try to understand how the body changes in weightlessness. We use a lot of analogs. We use things like bed-rest studies. Where we put people to bed for weeks or months on end, trying to see how the body changes in, with disuse. We've looked at vitamin D studies in the Antarctic, where people don't get sunlight. Like on spacecraft. So we study wherever and whatever we can to try to glean information about how the body changes. And how we can use nutrition to help mitigate negative effects of space flight or to optimize crew health. So we've done some studies on short-duration shuttle missions. But it wasn't until we started long-duration flights that we really started to worry about nutrient requirements and what crews needed to eat. And our first foray into that was the phase one program on the Russian space station Mir. And we did some studies there looking at things like calcium. And red blood cell metabolism. And fluid homeostasis. And then with the advent of, with the launch of Expedition One, we've been doing nutritional work in some form or other on every mission since then. So we do nutritional assessments on the space station crews. We're sort of the working for the flight surgeon. We collect data on the crews before flight. During flight. And after flight. To make sure that we send astronauts up there as healthy as can be. That we track them while they're up there to make sure they're staying healthy. And then when they land, we go off and we collect blood samples and urine samples to see if there are any decrements. That we work with the rehabilitation team to get crews back to full health as quickly as possible. Host: Well, what have you seen? So you've been doing this on station for a long time now. You did some stuff on Mir. What have you guys kind of, what did you start out looking for kind of? What is the body needing in microgravity that it's not, it wasn't necessarily getting? Or how did nutrition, let me put it this way. How did nutrition requirements change for an astronaut as opposed to, you know, me down here on planet Earth? Or do they? Scott Smith: There are a few nuanced differences. But really many of the basics still apply. When I meet with the crews before flight, the first thing I tell he them is that, if there's only one thing I can tell you, it's that you need to eat during flight. And that sounds ridiculous, but you need to maintain your body mass. You need to get enough calories in you to maintain your body mass. If you're doing that, that is 70 percent of the battle. And the reason for that is that, if you're getting enough calories, everything else follows calories. So if you're getting enough calories, you're probably getting enough of the body weight. You're probably getting enough of the minerals. You're probably getting enough fluid. And when we get caloric intake right, then we start to look at other things. Like are you getting enough protein? Are you getting enough calcium? Are you getting enough potassium? And we start to fine tune. But really maintaining body mass is goal one. We know from many flights that, if you lose weight during flight, that you'll lose more bone than you want to. You'll lose more muscle than you need to. Your cardiovascular system doesn't like it. There's more oxidative damage that occurs if you're not getting enough calories. So there's a lot of negative things that come along with weight loss in astronauts. And I always say this is not the weight loss program you want to go on. Over the years, early on in the Mir program, in the early station, we saw a lot of crews lose weight. There were a lot of people that maintained that, well, astronauts just lose weight in flight. We need to accept that that's normal. Host: Yeah. Scott Smith: And I always fault that. And it wasn't until, in 2008 was when we flew the, what we call the ARED, the advanced resistive exercise device. That device that allowed really heavy resistive exercise. And what we showed in the first crews that used that was that, if you ate well. Maintained your body mass. Had good vitamin D status. And exercised hard. You could maintain your bone mineral density. And my throw down on there was always that in 50 years of flying people in space, that was the first time we ever saw crews coming back with the same bone mineral density they left with. Host: And it was by actually paying attention to. [ Multiple Speakers ] Scott Smith: Nutrition and exercise. Host: Every factor not just accepting, hey, this is something we got to live with. Scott Smith: Exactly, exactly. And, you know, the adage always is that, you know, good nutrition won't make you an Olympic athlete. But if you're an Olympic athlete, bad nutrition will ruin you. And it's the same mantra. That, you know, we come up with an exercise that does a really good job of fixing muscle loss. Host: Yeah, yeah. Scott Smith: But if you're not providing enough fuel to support that exercise, that exercise won't work. Host: And then how are you guys actually making sure that the crew members are getting what they need? Scott Smith: We, in two ways. Again, we have an iPad app that the crews track dietary intake. That allows them to see literally at lunchtime what they need to eat for dinner to get enough calories. It's got a little bar at the bottom of the page that starts off at red. And as they eat more calories, it turns to green. So we push them daily, hour by hour to get to the top of that bar. We track their body mass. And if they're losing weight, again, that's the tell. And we've had some crew members that, you know, when we say you're not eating enough. You're not getting enough calories. They will, you know, push back and say, look, I feel fine. You know, I feel like I'm eating enough. I don't know what you're talking about. I always tell them, if you're losing weight, I'm right. That it's possible your metabolic rate is different. Host: Yeah. Scott Smith: Maybe lower than it is on Earth. Or lower than we think it is. But, again, the body weight is the tell. That, if you're body mass is going down, there's something wrong. And one of the things that we've come to, and I don't have data to back this up. But I think one of the things that happens during flight is that food doesn't settle in your stomach the same way as it does on Earth. Host: Really? Scott Smith: So as you eat here on Earth, eventually your stomach will tell your brain that you're full. Host: Yeah. Scott Smith: In space what I think what happens is because the food in your stomach is experiencing the same weightlessness, it probably is stretching that stomach more. So hitting the top of your stomach more, which is, signals your brain that you're done. Even though you haven't really eaten that much. And I tell crews, again, you've got to get food in you. And if you're losing weight, you either need to push more food in even when you think you're full. Host: Yeah. Scott Smith: Or you need to eat more meals. You need to spread it out during the day and snack more. Or whatever it takes to get more calories in you. Host: It's actually interesting. We've been asked that question before. You know, does the digestive system change at all? And it's always kind of a, no, we don't think so. So that might actually be out there still. So we're still learning stuff. Scott Smith: Exactly, exactly. Host: Are there foods that you try to make them eat more of? Eat less of? Because, I mean, everything's pretty regulated, I would imagine. Scott Smith: Well, there's a couple ways to answer that. We, the food system is somewhat limited. And it is repetitive. So every eight days or so they change out the containers and get a new set of the same thing every eight days. So there's not a lot we can tell them to do. And for a lot of reasons we don't, you know, obviously, I try not to nag them on, you know, I don't want to be the guy telling them to eat more broccoli. Especially if they hate broccoli. But trying to get a balanced meal in them. And trying, you know, one of the challenges we have is getting enough food up there. Enough variety of food that each individual crew member can find enough things that will make them happy. So for the crew, if it doesn't like broccoli, will they eat asparagus? Will they eat green beans? Will they eat something else? Because you got to get something green in you no matter what. As we look out to exploration missions and the challenges there, we want an optimal diet. We want an optimized diet. And in our view that means more fruits and vegetables. Which have phytochemicals that come along with that. It means more sources of omega three fatty acids. So things like salmon and fish and walnuts. And, again, doing what we can with that personal choice of making sure the crews are interested enough in eating that they're going to eat. You know, again, go back to their eight-day rotating menu. I would say, if you pick your eight favorite days of food and you cycle it enough, after enough times you're going to get bored. I don't care if it's steak and lobster and whatever else. Whatever it is you like. Host: I feel like I've already been doing that the last five years of my life. Scott Smith: If you eat the same thing every Tuesday. Host: Yeah, yeah, yeah. Scott Smith: Sooner or later we know you get bored of that. Host: I think every college student can attest to that. Scott Smith: Exactly. You can only do ramen so many days in a row. Host: Well, so what about, you know, the future? What are you guys already looking at that you're considering is going to have to change upwind. Because we have crew members up in the air for six months. We had Scott Kelly up there for a year. Scott Smith: Yeah. Host: What's going to change in the world of nutrition? What are you guys, you know, not necessarily worried about. But what problems are you already trying to solve? Or anticipating if someone's going to be up there for two, three years at a time? Scott Smith: We're still, there's a number of serious health concerns that we worry about. That, again, a six-month mission is worse than a three-month mission is worse than a two-week mission. And then when you add in a year or two-year mission, it just, it exacerbates that. We worry about things like bone loss. And muscle loss. And how your cardiovascular system works. We worry about the immune system function. And all four of those are intertwined with nutrition. We know, if you don't eat well, your immune system function doesn't work as well. We know from our work in the Antarctic that, if you are stressed and you're vitamin D status is low. You will reactivate more viruses, which is a function of your immune system, than you want. Your behavior. Your performance. Your morale are all based on how well you're eating. How well you're sleeping goes hand in hand with how well you're eating. So lots of different months of human adaptation rely on a good food system and good food intake. And then you take into account the fact that you're in a spacecraft. You're in microgravity. The air is closed. So any contaminants in the air can alter that. There's some things, you know, high levels of carbon dioxide can affect different nutrient metabolism. It can affect bone loss. Different chemicals and contaminants in the air can affect nutrient requirements like folate. And other vitamins can be exacerbated by that. And one of the bigger, if not the biggest issue we chase is radiation. And that's one of those things that, again, it's, radiation exposure is higher on station than it is on Earth. But when you leave the protection of low Earth orbit, it gets really bad. So radiation exposure on a moon mission or Mars mission and how we protect from that is going to be serious. Host: And that's something nutrition can help address? Scott Smith: That is something that nutrition can help address. Host: How? Scott Smith: When you look at, you know, studies on the ground. People that eat more broccoli and cauliflower, cruciferous vegetables, get less cancer. Host: Wow. Scott Smith: Do we know exactly why? No, we do not. And we, you know, people are always looking for what vitamin is it that I can take a pill of that will mitigate that? We don't have that yet. Host: Yeah. Scott Smith: And there's been a number of studies done where for a while we thought vitamin A was going to cure cancer. Vitamin E was going to cure cancer. And we did long-term prospective studies where, you know, ten-year studies where we looked at vitamin E supplementation. Or vitamin A supplementation. Beta carotene supplementation. And when they do those big studies, big controlled studies, what they find is that taking vitamins does not mitigate that risk. But, again, when you compare to people that eat more vegetables, they get less cancer. Now, there's a couple things intertwined in there that you need to be careful of. One is that there are thousands of these, what we call phytochemicals that occur in things like broccoli. And we don't understand all of them. So it may be that it's not just vitamin E or vitamin A. Host: It's some mix of. Scott Smith: It's some mix of those other things. The other thing is that the more broccoli you eat, the fewer french fries you eat. The fewer, less red meat you eat. Host: That's true. Scott Smith: And those things likely antagonize oxidative damage and cancer incidence. So it really, you know, I always hate to say it, but your mother was right. And eating your vegetables really does matter. Host: I'll make sure they does not listen to this podcast. Well, so what are some of the other major changes for when we have people in space for a really long time? One thing that I have written down here, need less iron and sodium. Now, why does that happen? What is the body going through that that becomes the case? Scott Smith: Two different things there. One, with iron, your iron stores go up during space flight because your blood volume contracts. So when you go into space flight, that, what happens is your blood volume goes down by about 10 to 15 percent. Host: Really? Scott Smith: Yeah. And, again, I don't have date to back this up exactly. But what I think happens, the way I explain this in my head is that it's easier for the body to pump blood to your toenails than it is on Earth. You don't have gravity fighting against you, so it's easier to pump the blood. You don't have blood pooling in your, you know, in your feet. Host: Yeah. Scott Smith: So your body can get away with a smaller blood volume. And what happens because of that is your blood volume contracts, again, by about 10 or 15 percent. What happens is, as you breakdown the red blood cells you don't need, you put that iron into stores, okay. So you don't need as much iron as you need on Earth, first of all. Second of all, when you have higher iron stores, and we know this from a lot of studies on Earth that have nothing to do with space flight. Higher iron stores are associated with higher oxidative damage in tissues. And we've actually shown that with high, the astronauts that have higher iron stores. Because they ate more iron. Because they had higher stores to begin with, have more oxidative damage to their DNA. And have more bone loss secondary to that oxidative stress. So we try to minimize the amount of iron they're getting in their diet. Now, that's not to say, you know, we'd be happy with the RDA. Which is about 8 or 10 milligrams of iron per day. The standard food system right now has about 25 milligrams a day. And depending on how each astronaut picks their food, if you pick foods that are, you know, either high in iron. Like sources of meat. Or fortified foods like breakfast drinks. And cereals that are fortified with iron. We've seen crews get 30, 40, 50 milligrams of iron a day. Which is a good four or five, six times the RDA. Host: What's RDA? Scott Smith: The recommended dietary allowance. Host: Okay. Scott Smith: So that's the, you know, when you look at the food package in the grocery store. Host: Yep. Scott Smith: It's based on your typical dietary intake, if you will. Host: Got you. Scott Smith: So we're not looking to reduce iron below what your average person needs. But on Earth we tend to worry about the opposite. We worry about people being iron deficient. Host: Yeah. Scott Smith: Most nutrients follow what we call a bell-shaped curve. That is, that at the bottom end of the bell-shaped curve, you don't want to be in the bottom 5 percent. [ Multiple Speakers ] But the reality is you don't want to be, you don't to have too much either. Host: Yep. Scott Smith: And we're starting to see that in terrestrial science that individuals that have higher iron stores have higher cardiovascular diseases. Have higher cerebrovascular diseases. That is, blood vessel changes and brain changes. And, again, we're seeing decrements, problems with having too much iron that are just as bad as problems of having too little iron. Sodium, on the other hand, is one of those things that we worry about crews using too much sodium for the same reason as on Earth. Because too much sodium is bad for you. Host: But it tastes so good. Scott Smith: And that is the problem. Not only that it tastes really good, but it's cheap. Host: Yeah. Scott Smith: So if you want to make something taste better and not cost much, throw some salt on it. Host: A little bit of salt, yeah. Scott Smith: You could do the same thing with spices. Spices are a lot more expensive. So if you're a food company trying to make whatever, macaroni and cheese. You know, or soup. Or whatever you want. It's much cheaper and much more palatable to add sodium to it. Host: But you're not watching out for sodium for any particular reason when [inaudible]? [ Multiple Speakers ] Scott Smith: Well, one of the key, well, there's several things we're concerned about. On Earth, with sodium, we worry about blood pressure. And we're not worried about that in astronauts. Because blood pressure actually is a little bit lower during flight. The astronauts, by virtue of the selection process, typically don't have blood pressure issues. High sodium levels are bad for bone, which is something we're concerned about. And there's the potential that high sodium intakes can exacerbate some of the fluid volume issues. And some of the eye issues that have jumped up in recent years. And that is one of the reasons why we reformulated our food system, I think about five years ago now, to be much lower in sodium than it was. So we actually reduced the sodium content of the space foods by about 40 percent compared to what they were to try to help with some of these health issues. And the big one was, the big driver was eye issues. Host: Eye issues. So we've talked about bone and muscles. And even radiation. But the vision issues. So, and for those that don't know, some of the astronauts actually experience a loss in their visual acuity. Their vision gets worse over long-duration space flight. And then it always doesn't get better; is that correct? Scott Smith: That's exactly right. That we, I'll say around eight years ago or so, nine years ago realized that we had some crew members coming back having had eye and vision issues. I say vision issues because it's easier to say than ophthalmologic issues. Host: That is easier. Scott Smith: And in some cases it's a change in what we call refraction. Which is your ability to focus. Some of them are a little more nuanced than that. Where, when the eye docs do an examine of the astronauts after flight, they see changes in the back of the eye that some astronauts have had, but didn't realize they had. So it's not necessarily perceptible by the astronaut. But there's a varied pattern of five or so different things that occur with the eye. Changes in ability to focus. Changes in the back of the eye, what they called cotton wool spots. Which are little spots that occur on the back of the eye. Changes in the shape of the eye. Number of things going on. As I said, up until about seven, eight, nine years ago, we didn't realize that was a problem. Now, when that came up, we all collectively blustered down the intracranial pressure pathway, as I call it. That is, the thinking was, the theory was that, when you go into space flight, the fluid shifts. And you get more blood and fluid up into your head. That that pressure inside your head pushes on the back of your eye. Pushes on your optic nerve. And that intracranial pressure leads to these eye changes. Now, what is important to keep in mind, and the drum I continually bang is what you said at the outset. Which is some astronauts develop this. Host: Yeah. Scott Smith: It's not all of them. Host: It's not. Scott Smith: So it can't just be as simple as, when you go into flight, the fluid goes up, pushes on your eye. Host: Because they all have that. Host: Right. They all have that. We at one point, and there's still some thinking that it might be related to carbon dioxide. Because carbon dioxide in the air is higher during space flight than it is on Earth. The cabin on, the cabin CO2 on ISS is higher than the CO2 you and I are breathing. Maybe not in this room. Host: There's good airflow in here. It's a small room. There's good airflow. Scott Smith: Okay. No worries. It may be CO2. It may be fluid shifts. It may be something else. But what we always come back to is that it is only affecting some of the astronauts. Now, when this came up, we went to the flight docs and said, look, you know, we've got a lot of data. We've done this experiment on space station. We've collected blood. We've collected urine. We've looked at a lot of nutritional markers and biochemistry markers. Maybe we have something that could help understand this. And when we dug into the data, and today's February 16th. It was February 18th of 2011 that my colleague Sarah [inaudible] came into my office and said there's something going on with one carbon metabolism. And without boring you with all the details, what she found was differences in the blood biochemistry of the astronauts that had these vision issues before flight. Host: Before flight. Scott Smith: Before flight we saw differences in the blood in astronauts that subsequently developed eye issues. Host: So with that you could potentially tell before somebody even went into space. Scott Smith: Indeed. Host: Whether or not they have that issue. Scott Smith: Indeed. So we followed up on that. We presented that to life sciences management. We ruled out as many things as we could. You know, the possibility that it was vitamin deficiencies. Or kidney function. Or all these different things. We ruled those all out. And what we then hypothesized was that it was related to genetics. That there were genetic differences, in the literature we knew there were genetic differences that affected the chemicals we were looking at. And these affect the population. That's sort of like blood types. That people have different blood types. Host: Yeah. Scott Smith: You're either blood type A or B or O. It's not a good blood type or a bad blood type, there's just different blood types. There's differences in genetics that affect these chemicals. And we hypothesized that that may be why these chemical differences are there. And there may be something related to that which is causing those individuals to be predisposed to developing these eye issues on space station. So we did a study where we proposed looking at a handful of these genetic differences. We sat down with 70 astronauts and said, you know, look, here's the story. Here's the data we've got. Here's the theory. We'd like to collect some blood from you and look at your genes. We said it was 70 astronauts, and all 70 of them agreed to give us blood. Which gives you an idea of how compelling the story was to them. And how big a deal this is to astronauts. And how much they want to understand this to figure this out. Host: I always say they're incredibly selfless because they're basically guinea pigs. Scott Smith: Yeah, absolutely. Host: While they're up there. Scott Smith: Absolutely. [ Multiple Speakers ] Host: So it's incredible that they're. Scott Smith: And the astronauts as a whole are great about doing experiments. But I always, you know, I've always said, all the astronauts will never agree to anything. That, you know, there's always 95 percent of them. There's always one or two, they're like, well, I don't like to collect blood or. Host: Yeah. Scott Smith: Cardiovascular study. Or I don't want to do that sleep study. I've never even everybody sign up for a study until now. Host: And so it's still ongoing? Scott Smith: It, we're in stage two now. But when we collected the blood, we did a small look at the genetics. And found, indeed, that there was a genetic predisposition for some astronauts to develop these eye issues. And we now need to follow up on that. We're doing some more extended work. Again, I can talk to you a long time about that. But I'd be more boring than I already am. And it gets pretty gnarly into the genetics and the biochemistry. But I am convinced that we are at the cusp of this thing. And if we can work it out to where we can study this in a little more detail, that we will solve this problem. Host: Wow. Scott Smith: To where we can get into what we call personalized medicine. And we can look and say, okay, we know these individuals are going to be, are at risk of this developing. Here's how we go try to counteract that. Host: Really? And so that's the important part. Is it's not identifying, hey, this is going to happen to you. It's, hey, this might happen to you, and this is how we stop it. [ Multiple Speakers ] Scott Smith: And here's how we fix it. Absolutely. Host: And so we've come all the way from why is half of my ship dying from some crazy thing. To now we're looking at eyes. So it seems like, obviously, it's a constantly evolving field. Are there other things or anything on the horizon that you think you're going to be diving into next? Scott Smith: Well, right now the vision thing is, as I call it, is the biggest thing we're chasing. Host: Yeah. Scott Smith: And that is one of the top concerns that NASA management has in terms of health risks. One of the interesting spinoffs of the work that we've done is that, is we wrote up the genetic data. We published that in a scientific paper. One of the realizations we came to was that the astronauts that developed these vision issues had a long list of characteristics. This chemistry. The genetics. Changes in their retinal nerves. Changes in some of their hormones. There was a list of about eight or nine things that we had that we found a clinical population that had the exact same set of characteristics. And that is women with polycystic ovary syndrome. Host: Really? Scott Smith: Really. Polycystic ovary syndrome, or PCOS as they call it, is the leading cause of infertility in women. It affects 10 to 20 percent of women. Which is a staggering incidence. Host: Yeah. Scott Smith: And what we maintain is that, you know, I talked a lot about analogs. That we look at the Antarctic as analog to study vitamin D. Or we look at bed rest as an analog for studying bone loss. Host: Yeah. Scott Smith: We maintain that women with polycystic ovary syndrome might be the analog population we need to study to figure out what's different about them. And how that relates to astronauts during space flight. Host: Go you. I was wondering, like, what, so if you find that out, what's the purpose of finding that out [inaudible]? Scott Smith: Because we can then study their cardiovascular function. We can study their eyes. We can study, you know, different elements of their physiology to understand what's different about them. Because, theoretically, if we flew women with PCOS in space, again theoretically, they would all develop these eye issues. Host: Yeah. Scott Smith: We've started a study that we're doing with the Mayo Clinic up in Minnesota. Working with an endocrinologist who specializes in PCOS and a neuroophthalmologist. Which is even harder to say. A neuroophthalmologist that specializes in intracranial hypertension. And they're off recruiting women with PCOS. Patients with intracranial hypertension. Where they're collecting blood and shipping them to us and doing eye exams. And, again, we hope to piece together the first bits of that. So we can then test our hypotheses for what we think is the relationship between your genetics and your eyes. And how those change during space flight. So that, you know, again, ultimately those studies can help us better understand how to prevent astronauts from having eye issues. The more staggering thing is that we might be able to help terrestrial medicine to understand how to better treat individuals with that syndrome. Host: Yeah. Scott Smith: And I'm always struck by one of the cases where we published the genetic data back in 2016. And when we published the paper, NASA put a story on the web about, you know, that we published the study. And what we found and what it meant. And I got an e-mail from a woman working at one of the other NASA centers who asked if we'd looked at this one eye issue called papilledema. And I said, well, in our paper we called it choroidal folds. But I'm told they're about the same thing. But, yes, we did and here's a copy of the paper. And she wrote back and said. Well, to share too much, I six, seven years ago was diagnosed with papilledema. That there was some sort of pressure pushing on the back of my eye that they couldn't figure out why. Along the way I was diagnosed with B12 deficiency. Which is one of the things intertwined with the genetics we're looking at. And, oh, yeah, by the way, she's got PCOS. Host: Wow. Scott Smith: And that could be a coincidence. I don't think so. Host: Wow. Scott Smith: And she said, when she had mentioned to her physicians that maybe these things were interrelated. And she said they scoffed at her and said, no, that can't be. So, again, we talk a lot about spinoffs from the space program. It is mind-boggling to think that by studding this in more depth. Host: Yeah. Scott Smith: We might be able to help 10 to 20 percent of the population. Host: Wow. Well, wow, I've said that like a million times already. But, wow. [ Multiple Speakers ] Host: Keep going. Host: So besides the vision, everything that we've been learning on the space station about trying to solve the vision issue. Bones. Muscle. And cardiovascular everything. How are you feeling with what we know right now about supporting the nutrition for our crews, say going to Mars? Going into space for two years? Scott Smith: Again, the human research program has a top four, if you will. And I don't mean to speak for HRP, but their top four our radiation. Behavior and performance. Vision. And food. And I say food intentionally. It's not nutrition. Because the reality is for a Mars mission, the food is probably going to go to Mars before the crew leaves Earth. So we need to have a food system that is stable for five years. Meaning you could go to the grocery store right now. Pack your pantry. And in five years still be eating that food. And make sure that it's got everything you need in it. Host: And I imagine there's a million and one challenges. [ Multiple Speakers ] Scott Smith: And it's extremely tough to do. Host: Yeah. Scott Smith: It's extremely tough to do. The food system folks are working really hard on developing foods that are more stable. Working on packaging that will help facilitate that. But, again, when you think about it, when you find something in the back of your pantry that's been in there are for a while. It's got an expiration date on it. The expiration date is because it probably doesn't taste that good. The reason it probably doesn't taste that good after that date is because the nutrients that are in there break down and make other chemicals that aren't what they were supposed to be. So it tastes funky or it looks funky. So from a pure food point of view, there's a lot of issues. From a nutrition point of view, we need to make sure we've got the basics down. One of the nice things we have on space station is that, every time a vehicle goes up, there's some fresh food in there. Host: Yeah. Scott Smith: There's, you know, oranges. And lemons. And apples. And different types of fruits and vegetables. Host: Got to stave off the scurvy. Scott Smith: Exactly. And we really don't know how much that little bit of fresh food mitigates concerns we have about the rest of the food system. We're not going to have the ability to do that with a Mars crew. So we need to be very sure of that. We need to make very sure the food, again, is good enough that the crew's going to want to eat it. We're going to make sure that the crew is motivated enough that they're going to want to eat it. That they're exercising hard enough to maintain their body to keep, again, that whole thing going. So it, you know, when you look at scientists, we all tend to focus on our little system. So there's a bone lab. And a muscle lab. And a cardiovascular lab. And a nutrition lab. We're dealing with a human. And that whole thing has to work. And that still gives me a significant amount of pause. We don't really know what extent the effects of the radiation system are going to be. Chronic, relatively low dose, but much higher than on Earth. Levels of radiation for long periods of time can affect, you know, I was at a meeting last week where the radiation folks talked about that. And talked about how, you know, you get dementia-like problems with extended radiation exposure. And, again, from a nutrition point of view, I will tell you that in the elderly with dementia and cognition problems, folate. Which is one of the vitamins, vitamin B12 are key nutrients when it comes to cognition. And one of the things that we think is going on is that radiation affects the ability to get those vitamins into the brain. So there are a lot of challenges ahead of us that we really do not understand. If we had a vehicle that was ready to go tomorrow. We had a food system that was ready to go tomorrow. Do we know enough about what it really is going to take to protect crews on a three-year trip to Mars? Those really are scary questions. Host: Yeah. Scott Smith: Really they are. Host: Well, luckily we still got an International Space Station and some time to figure all that out. I've taken up a bunch of your time. Anything else that I didn't hit on that you're dying to go tell the world about nutritional biochemistry? Scott Smith: No. I think we've hit most of the key points. We, you know, are working as hard as we can. And I always like to step back from the realization that, you know, I get to come sit here with you and tell you the great stuff we're doing. Realize I've got a lab full of folks that are back at the lab working hard. That are doing the really hard work. And they should get most of the credit. But I don't let them out of the lab so, you know, they're working. But it really is a phenomenal team effort that helps to bring all this together. Host: How's their vitamin D intake? Scott Smith: We let them out in the sun every once in a while. But it is a tremendous team effort within our group. And then we work with a number of other groups. We work with the cardiovascular lab to try to understand a lot of the cardiovascular and vision issues that we've talked about. Work with the immune lab. Work with the muscle lab. We work with a lot of other folks. There really is a tremendous team environment trying to pull this thing together. It's not, really is not just me. Host: Well, you're all doing some incredible work right now. And looking forward to the next breakthroughs in the years to come. Scott Smith: Thanks. Host: And what the future holds. Again, I was just talking with Dr. Scott Smith, the manager of nutritional biochemistry here at the Johnson Space Center. Scott, thanks so much for joining me today. Scott Smith: Thank you. [ Music ] Host: Hey, everyone. Thanks for sticking around to the end. If you liked that, go check out all of the earlier episodes of, Houston, we had a podcast. And check out some of our other NASA podcasts. Like gravity assist and NASA in Silicon Valley to learn even more about what NASA's doing right now. To learn more about the International Space Station, which is the focus on a lot of our stuff here at the Johnson Space Center. You can always go to nasa.gov/iss. Or follow us on social media. We have a Facebook page. A Twitter page @space underscore station. And on Instagram at ISS. And on any of those platforms, you can use the hashtag ask NASA to submit your idea for a potential podcast. This podcast was recorded on February 16th. Special thanks to Kathy Reeves. Kelly Humphries. Isidro Reyna. Greg Wiseman. And Gary Jordan. And, of course, to my guest Dr. Scott Smith for coming on the show. We'll be back next week.

The effect of mare obesity and endocrine function on foal birthweight in Thoroughbreds.

PubMed

Smith, S; Marr, C M; Dunnett, C; Menzies-Gow, N J

2017-07-01

Birthweight of Thoroughbred foals has increased in recent years. It is unknown whether this is associated with increased broodmare obesity or endocrine dysfunction. To determine insulin, leptin and triglyceride concentrations in Thoroughbred mares throughout gestation and investigate their association with obesity and foal birthweight. Cohort study. A total of 66 mares were included from 40 days post-breeding. Body condition score (BCS), weight and blood samples were obtained every 60 days throughout gestation. Serum/plasma insulin, leptin and triglyceride concentrations and foal birthweight were recorded. Associations between hormone/triglyceride concentration with BCS, stage of gestation and birthweight were analysed using a linear mixed effects model. Serum insulin concentrations were greater at 1-60 days (4.31 μiu/mL) compared with 241-300 days (3.13 μiu/mL) and 61-120 days (5.33 μiu/mL) compared with 181-240, 241-300 and 301-360 days (3.78, 3.13, 3.37 μiu/mL) gestation (P<0.05). There was no significant hyperinsulinaemia and no association of insulin concentration with BCS. Leptin concentration was greater at 181-240 days (2.28 μg/L, P<0.0001) compared with all other time points and correlated with BCS (P<0.0003). Triglyceride concentration was greater at 241-300 days (0.245 mmol, P<0.02) compared with earlier time points, but was not associated with BCS. Foal birthweight was weakly positively correlated with BCS (r = 0.13, P<0.001) and inversely correlated with leptin concentrations at 61-120 and 241-300 days gestation (r = -0.64, P<0.05). Reduction in sample size over the study and tight clustering of BCS. Mare BCS correlated with foal birthweight; obese mares had heavier foals. Significant hyperinsulinaemia was not identified in this population. Increased leptin concentration in early and late gestation was associated with decreased foal birthweight. Further work is required to establish whether leptin concentration in late gestation could predict foal birthweight. © 2016 EVJ Ltd.

Survey of Veterinarians Using a Novel Physical Compression Squeeze Procedure in the Management of Neonatal Maladjustment Syndrome in Foals

PubMed Central

Weich, Kalie M.; Madigan, John E.

2017-01-01

Simple Summary Neonatal foals must pass key milestones for survival such as standing and sucking from the mare shortly after birth. A condition known as neonatal maladjustment syndrome (NMS), or “dummy foal syndrome”, is characterized by failure to stand, suck, and follow their mare, putting them at risk of malnourishment, infection, and death. NMS had been presumed to be exclusively caused by low oxygen in the foal during the perinatal period. More recently, however, our group demonstrated the presence of neuroactive steroids in foals that exhibited the altered behavior and consciousness characteristic of the disorder. It has been hypothesized that signaling the transition from the in utero unconscious state to extrauterine consciousness may involve labor-induced physical compression (squeezing). During normal birth, foals experience such physical compression for approximately 20 min during stage-2 labor. Current medical treatments for NMS are symptomatic and supportive, which may require 2–7 days of veterinary care. Anecdotal evidence demonstrated that a novel physical compression (squeeze method) that applies 20 min of sustained pressure to the chest of neonatal foals exhibiting this syndrome might rapidly hasten recovery. This survey compares reported outcomes of medical therapy alone to this squeeze procedure with or without medical therapy. The results revealed some foals that received the squeeze procedure recovered faster than those that received medical therapy only. Abstract Horses are a precocious species that must accomplish several milestones that are critical to survival in the immediate post-birth period for their survival. One essential milestone is the successful transition from the intrauterine unconsciousness to an extrauterine state of consciousness or awareness. This transition involves a complex withdrawal of consciousness inhibitors and an increase in neuroactivating factors that support awareness. This process involves neuroactive hormones as well as inputs related to factors such as cold, visual, olfactory, and auditory stimuli. One factor not previously considered in this birth transition is a yet unreported direct neural reflex response to labor-induced physical compression of the fetus in the birth canal (squeezing). Neonatal maladjustment syndrome (NMS) is a disorder of the newborn foal characterized by altered behavior, low affinity for the mare, poor awareness of the environment, failure to bond to the mother, abnormal sucking, and other neurologically-based abnormalities. This syndrome has been associated with altered events during birth, and was believed to be caused exclusively by hypoxia and ischemia. However, recent findings revealed an association of the NMS syndrome with the persistence of high concentrations of in utero neuromodulating hormones (neurosteroids) in the postnatal period. Anecdotal evidence demonstrated that a novel physical compression (squeeze) method that applies 20 min of sustained pressure to the thorax of some neonatal foals with this syndrome might rapidly hasten recovery. This survey provides information about outcomes and time frames to recovery comparing neonatal foals that were given this squeeze treatment to foals treated with routine medical therapy alone. Results revealed that the squeeze procedure, when applied for 20 min, resulted in a faster full recovery of some foals diagnosed with NMS. The adjunctive use of a non-invasive squeeze method may improve animal welfare by hastening recovery and foal–mare interactions that minimize health problems. This would also avoid or reduce costs arising from hospitalization associated with veterinary and nursing care that sometimes leads owners to elect for euthanasia. PMID:28872596

KSC-97PC855

NASA Image and Video Library

1997-05-24

This unusual view of the underside of the Space Shuttle orbiter Atlantis shortly before landing was taken by a fish-eye camera lens from KSC’s Shuttle Landing Facility. The Vehicle Assembly Building is in the background at left. The Shuttle Training Aircraft can be seen in the distance, at center. Atlantis is wrapping up its nine-day STS-84 mission, which was the sixth docking of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger is returning to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and Jean-Francois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

KSC-97PC839

NASA Image and Video Library

1997-05-24

The Space Shuttle orbiter Atlantis touches down on Runway 33 of the KSC Shuttle Landing Facility, bringing to an end the nine-day STS-84 mission. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

KSC-97PC843

NASA Image and Video Library

1997-05-24

The Space Shuttle orbiter Atlantis touches down on Runway 33 of the KSC Shuttle Landing Facility, bringing to an end the nine-day STS-84 mission. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

KSC-97PC852

NASA Image and Video Library

1997-05-24

The Space Shuttle orbiter Atlantis touches down on Runway 33 of the KSC Shuttle Landing Facility, bringing to an end the nine-day STS-84 mission. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

KSC-97PC838

NASA Image and Video Library

1997-05-24

The Space Shuttle orbiter Atlantis touches down on Runway 33 of the KSC Shuttle Landing Facility, bringing to an end the nine-day STS-84 mission. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

Evaluation of ivermectin against later fourth-stage Strongylus vulgaris in ponies at two and five weeks after treatment.

PubMed

Slocombe, J O; McCraw, B M

1984-10-01

The efficacy of ivermectin against later fourth-stage Strongylus vulgaris larvae was studied in pony foals at 14 and 35 days after treatment. These foals had been reared parasite-free, inoculated with 500 infective larvae and 56 days later given either ivermectin at 200 micrograms/kg or a placebo intramuscularly. At necropsy, foals were examined for lesions and larvae grossly and histologically. Ivermectin was found to be highly effective (98.6%) against later fourth-stage larvae in five foals which were examined at 35 days after treatment, but not in five others examined at 14 days (72.5%). In some foals larvae were found in the tunica media of the ileocolic arteries. The conformation of these larvae appeared normal, but there were degenerative changes which suggested that they were dying or dead. Questions as to how the larvae attained that site and the consequences of their presence there were raised.

Evaluation of ivermectin against later fourth-stage Strongylus vulgaris in ponies at two and five weeks after treatment.

PubMed Central

Slocombe, J O; McCraw, B M

1984-01-01

The efficacy of ivermectin against later fourth-stage Strongylus vulgaris larvae was studied in pony foals at 14 and 35 days after treatment. These foals had been reared parasite-free, inoculated with 500 infective larvae and 56 days later given either ivermectin at 200 micrograms/kg or a placebo intramuscularly. At necropsy, foals were examined for lesions and larvae grossly and histologically. Ivermectin was found to be highly effective (98.6%) against later fourth-stage larvae in five foals which were examined at 35 days after treatment, but not in five others examined at 14 days (72.5%). In some foals larvae were found in the tunica media of the ileocolic arteries. The conformation of these larvae appeared normal, but there were degenerative changes which suggested that they were dying or dead. Questions as to how the larvae attained that site and the consequences of their presence there were raised. Images Fig. 1.,Fig. 2.,Fig. 3.,Fig. 4.,Fig. 5.,Fig. 6. PMID:6391639

Effect of age on the concentrations of amino acids in the plasma of healthy foals.

PubMed

Zicker, S C; Spensley, M S; Rogers, Q R; Willits, N H

1991-07-01

The concentrations of 23 amino acids in the plasma of 13 healthy foals were determined before suckling, when foals were 1 to 2 days old, 5 to 7 days old, 12 to 14 days old, and 26 to 28 days old. The ratio of the branched chain amino acids to the aromatic amino acids was also calculated at the 5 time points. Analysis of the concentrations at the 5 ages revealed a significant temporal relationship for each amino acid ranging from a polynomial order of 1 to 4 inclusively. There were significant differences between several concentrations of amino acids in plasma at specific sample times; however, no consistent patterns were revealed. The concentrations of amino acids in healthy foals were markedly different from previously determined values in adult horses. The significant differences in the concentrations of amino acids in plasma of healthy foals at the 5 ages may represent developmental aspects of amino acid metabolism or nutrition.

Comparison between surgical and standing percutaneous contact Nd:YAG laser periosteal transection for potential treatment of equine limb deformities

NASA Astrophysics Data System (ADS)

Tate, Lloyd P.; Baines, Steven J.; Meuten, Donald J.; Stefanacci, J.

1994-09-01

Medial and lateral aspects of both radiuses were subjected to periosteal transection of nine healthy equine foals. One site per foal was subjected to surgical periosteal transection and elevation under general anesthesia. The remaining three sites of each foal after injection of a local anesthetic received Nd:YAG contact percutaneous periosteal transection. All radiuses were evaluated radiographically prior to periosteal transection and immediately prior to euthanasia. Foals were euthanized at 3 days, 31 to 34 days, and 67 days post-periosteal transection and gross postmortem and histologic examination performed on each site. Radiographically, periosteal proliferation occurred at all the conventional surgery sites and a majority of the percutaneous laser sites by 30 days post-treatment and was present at 67 days. No limb angulations were noted to occur in any of the foals. The conclusion of the study was that Nd:YAG percutaneous laser periosteal transection was successful in producing periosteal obliteration but with a different histologic appearance than that produced by conventional surgery.

Effects of low-dose hydrocortisone therapy on immune function in neonatal horses

PubMed Central

Hart, Kelsey A.; Barton, Michelle H.; Vandenplas, Michel L.; Hurley, David J.

2011-01-01

Low-dose hydrocortisone therapy modulates inflammatory responses in adults and improves outcomes in some septic adults and neonates, but its immunologic effects have not been evaluated in neonates. The objective of this study was to evaluate effects of low-dose hydrocortisone (LDHC) therapy on ex vivo immune function in neonatal horses (foals). We hypothesized that LDHC treatment would dampen pro-inflammatory responses without impairing neutrophil function. Hydrocortisone (1.3 mg/kg/day i.v.) was administered to foals in a tapering 3.5 day course. Peripheral blood leukocytes were collected from foals before, during and after hydrocortisone treatment. A separate group of age-matched untreated foals served as controls. Endotoxin-induced peripheral blood mononuclear cell gene expression of inflammatory cytokines was measured by real time quantitative RT-PCR. Neutrophils were incubated with labeled, killed S. aureus or E. coli for assessment of phagocytosis, and with phorbol myristate acetate, zymosan, or endotoxin for measurement of reactive oxygen species (ROS) production. Neutrophil phagocytosis and ROS production were similar in both groups. Foals receiving hydrocortisone had significantly decreased endotoxin-induced expression of TNF-α, IL-6, IL-8, and IL-1β. These data suggest that this LDHC treatment regimen ameliorates endotoxin-induced pro-inflammatory cytokine expression in neonatal foals without impairing innate immune responses needed to combat bacterial infection. PMID:21430601

STS-86 Crew Photo outside hatch in LC-39A White Room

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 crew members pose for a group photograph outside the hatch to the crew cabin of the Space Shuttle Atlantis at Launch Pad 39A. Kneeling in front, from left, are Mission Specialists Vladimir Georgievich Titov of the Russian Space Agency, David A. Wolf and Wendy B. Lawrence. Standing, from left, are Pilot Michael J. Bloomfield, Mission Specialist Scott E. Parazynski, Commander James D. Wetherbee, and Mission Specialist Jean-Loup J.M. Chretien of the French Space Agency, CNES. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25.

Final crew portrait of STS-84 and Mir 23 crew in the Spacehab

NASA Image and Video Library

1997-05-22

STS084-380-019 (15-24 May 1997) --- In the last minutes of joint activity between the STS-84 and Russian Space Agency (RSA) Mir-23 crews, ten astronauts and cosmonauts pose for an in-space portrait in the Space Shuttle Atlantis Spacehab Double Module (DM). For orientation purposes, photo should be held with clasped hands of Aleksandr I. Lazutkin (wearing Mir-23 suit) just below center. The flight engineer is flanked by similarly attired crew mates Vasili Tsibliyev, Mir-23 commander, on the left, and C. Michael Foale, cosmonaut guest researcher, on the right. The STS-84 crew members are, clockwise from the left, Jerry M. Linenger, mission specialist; Eileen M. Collins, pilot; Edward T. Lu, mission specialist; Jean-Fran?ois Clervoy, payload commander; Elena V. Kondakova and Carlos I. Noriega, both mission specialists, along with Charles J. Precourt, mission commander.

KSC-97pc672

NASA Image and Video Library

1997-04-19

McDonnell Douglas-SPACEHAB technicians oversee the move of a Russian-made oxygen generator to a SPACEHAB Double Module, at rear, in the SPACEHAB Payload Processing Facility. In foreground, from left, are Marc Tuttle, Dan Porter and Mike Vawter. The oxygen generator, manufactured in Russia by RSC Energia, will be carried aboard the Space Shuttle Atlantis on Mission STS-84 for the Shuttle’s scheduled docking with the Russian Space Station Mir next month. The nearly 300-pound generator will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff

STS-84 oxygen generator for Mir on display at SPACEHAB

NASA Technical Reports Server (NTRS)

1997-01-01

An oxygen generator destined to replace a malfunctioning unit on the Russian Mir Space Station is the object of much curiosity during preflight preparations in the SPACEHAB Payload Processing Facility. A SPACEHAB Double Module on the Space Shuttle Atlantis will carry the oxygen generator to Mir during STS-84, the sixth Shuttle-Mir docking. The nearly 300-pound generator, manufactured by RSC Energia in Russia, will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff.

STS-84 oxygen generator for Mir installation

NASA Technical Reports Server (NTRS)

1997-01-01

In the SPACEHAB Payload Processing Facility, McDonnell Douglas- SPACEHAB technicians prepare a Russian-made oxygen generator for flight in a SPACEHAB Double Module. The oxygen generator, manufactured in Russia by RSC Energia, will be carried aboard the Space Shuttle Atlantis on Mission STS-84 for the Shuttles scheduled docking with the Russian Space Station Mir next month. The nearly 300-pound generator will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking.

STS-84 oxygen generator for Mir installation

NASA Technical Reports Server (NTRS)

1997-01-01

McDonnell Douglas-SPACEHAB technicians oversee the move of a Russian-made oxygen generator to a SPACEHAB Double Module, at rear, in the SPACEHAB Payload Processing Facility. In foreground, from left, are Marc Tuttle, Dan Porter and Mike Vawter. The oxygen generator, manufactured in Russia by RSC Energia, will be carried aboard the Space Shuttle Atlantis on Mission STS-84 for the Shuttles scheduled docking with the Russian Space Station Mir next month. The nearly 300-pound generator will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff.

Use of manual alveolar recruitment maneuvers to eliminate atelectasis artifacts identified during thoracic computed tomography of healthy neonatal foals.

PubMed

Lascola, Kara M; Clark-Price, Stuart C; Joslyn, Stephen K; Mitchell, Mark A; O'Brien, Robert T; Hartman, Susan K; Kline, Kevin H

2016-11-01

OBJECTIVE To evaluate use of single manual alveolar recruitment maneuvers (ARMs) to eliminate atelectasis during CT of anesthetized foals. ANIMALS 6 neonatal Standardbred foals. PROCEDURES Thoracic CT was performed on spontaneously breathing anesthetized foals positioned in sternal (n = 3) or dorsal (3) recumbency when foals were 24 to 36 hours old (time 1), 4 days old (time 2), 7 days old (time 3), and 10 days old (time 4). The CT images were collected without ARMs (all times) and during ARMs with an internal airway pressure of 10, 20, and 30 cm H 2 O (times 2 and 3). Quantitative analysis of CT images measured whole lung and regional changes in attenuation or volume with ARMs. RESULTS Increased attenuation and an alveolar pattern were most prominent in the dependent portion of the lungs. Subjectively, ARMs did not eliminate atelectasis; however, they did incrementally reduce attenuation, particularly in the nondependent portion of the lungs. Quantitative differences in lung attenuation attributable to position of foal were not identified. Lung attenuation decreased significantly (times 2 and 3) and lung volume increased significantly (times 2 and 3) after ARMs. Changes in attenuation and volume were most pronounced in the nondependent portion of the lungs and at ARMs of 20 and 30 cm H 2 O. CONCLUSIONS AND CLINICAL RELEVANCE Manual ARMs did not eliminate atelectasis but reduced attenuation in nondependent portions of the lungs. Positioning of foals in dorsal recumbency for CT may be appropriate when pathological changes in the ventral portion of the lungs are suspected.

Effects of body condition and leptin on the reproductive performance of Lusitano mares on extensive systems.

PubMed

Fradinho, M J; Correia, M J; Grácio, V; Bliebernicht, M; Farrim, A; Mateus, L; Martin-Rosset, W; Bessa, R J B; Caldeira, R M; Ferreira-Dias, G

2014-06-01

The aim of this study was to investigate the effects of body condition (BC), BC changes, and plasma leptin concentrations on the reproductive performance of Lusitano broodmares on extensive systems. Data from 119 mares (ranging from 4 to 22 years of age) were collected over a period of four consecutive breeding seasons. Each case was considered as one foaled mare bred in 1 year. Body condition changes at conception (ΔBCScon) showed a strong effect on fertility at the first two postpartum estrous cycles and a significant interaction with body condition score at conception (BCScon) was observed (P < 0.01). The best fertility results were obtained with positive and greater ΔBCScon. The best predictive value of fertility (91%) was achieved when the BCScon was 3.0 and ΔBCScon was 0.375. Global foaling rate for the 4-year period was 74.5%. Mean foaling interval and gestation length were, respectively, 368.0 ± 2.8 and 340.3 ± 1.0 days. Gestation length was influenced by the month of foaling (P < 0.05) and decreased as mares got older (P < 0.01). The number of estimated estrous cycles per live foal was 1.78 ± 0.12, including foal heat ovulation. Leptin was correlated with BCS (0.41; P < 0.001), but in the present study, plasma leptin concentrations on late gestation and early lactation did not influence fertility results. At 90 days of age, lower growth performances were obtained in foals which dams presented negative BCS changes on the first 3 months of lactation (P < 0.05). In conclusion, BC changes at early postpartum period influence the reproductive efficiency of broodmares and the growth of their suckling foals. These findings are important to help breeders on management options concerning feeding strategies in the Lusitano production systems and others under similar conditions. Copyright © 2014 Elsevier Inc. All rights reserved.

Changes in Serum Strongylus Vulgaris-Specific Antibody Concentrations in Response to Anthelmintic Treatment of Experimentally Infected Foals.

PubMed

Nielsen, Martin Krarup; Scare, Jessica; Gravatte, Holli Sullivan; Bellaw, Jennifer Lynn; Prado, Julio C; Reinemeyer, Craig Robert

2015-01-01

Strongylus vulgaris is the most pathogenic nematode parasite of horses. Its extensive migration in the mesenteric blood vessels can lead to life-threatening intestinal infarctions. Recent work has shown that this parasite is still identified among managed horse populations. A serum enzyme-linked immunosorbent assay (ELISA) has been developed for the detection of migrating larvae of S. vulgaris. Previous work has documented an increase in ELISA values following larvicidal treatment with ivermectin and suggested that the target parasite antigen is primarily produced by the later larval stages. The aim of this study was to experimentally inoculate cohorts of foals with S. vulgaris, and then compare ELISA responses to early or later ivermectin treatments. Fifteen foals were held in confinement and infected orally with ~25 S. vulgaris third-stage larvae on Days 0, 7, 14, and 21. Foals were weaned on Day 43 and turned out to a pasture not previously grazed by horses. Foals remained at pasture continuously until the study was terminated on Day 196. On Day 55, foals were randomly allocated to three treatment groups of five each. Group 1 received ivermectin on Day 56, Group 2 received ivermectin on Day 112, and Group 3 foals served as untreated controls. Serum and fecal samples were collected at 28-day intervals throughout the study. Serum samples were analyzed with the S. vulgaris-specific ELISA and fecal samples were processed for fecal egg counting. The ELISA values of Group 1 foals were significantly lower than Groups 2 or 3 on Days 140-196. Both treated groups exhibited increased ELISA values following ivermectin treatment. Results indicate that the target diagnostic antigen is produced throughout the course of arterial infection with S. vulgaris, but that an early ivermectin treatment can reduce the cumulative antigen produced over the course of an infection.

Changes in Serum Strongylus Vulgaris-Specific Antibody Concentrations in Response to Anthelmintic Treatment of Experimentally Infected Foals

PubMed Central

Nielsen, Martin Krarup; Scare, Jessica; Gravatte, Holli Sullivan; Bellaw, Jennifer Lynn; Prado, Julio C.; Reinemeyer, Craig Robert

2015-01-01

Strongylus vulgaris is the most pathogenic nematode parasite of horses. Its extensive migration in the mesenteric blood vessels can lead to life-threatening intestinal infarctions. Recent work has shown that this parasite is still identified among managed horse populations. A serum enzyme-linked immunosorbent assay (ELISA) has been developed for the detection of migrating larvae of S. vulgaris. Previous work has documented an increase in ELISA values following larvicidal treatment with ivermectin and suggested that the target parasite antigen is primarily produced by the later larval stages. The aim of this study was to experimentally inoculate cohorts of foals with S. vulgaris, and then compare ELISA responses to early or later ivermectin treatments. Fifteen foals were held in confinement and infected orally with ~25 S. vulgaris third-stage larvae on Days 0, 7, 14, and 21. Foals were weaned on Day 43 and turned out to a pasture not previously grazed by horses. Foals remained at pasture continuously until the study was terminated on Day 196. On Day 55, foals were randomly allocated to three treatment groups of five each. Group 1 received ivermectin on Day 56, Group 2 received ivermectin on Day 112, and Group 3 foals served as untreated controls. Serum and fecal samples were collected at 28-day intervals throughout the study. Serum samples were analyzed with the S. vulgaris-specific ELISA and fecal samples were processed for fecal egg counting. The ELISA values of Group 1 foals were significantly lower than Groups 2 or 3 on Days 140–196. Both treated groups exhibited increased ELISA values following ivermectin treatment. Results indicate that the target diagnostic antigen is produced throughout the course of arterial infection with S. vulgaris, but that an early ivermectin treatment can reduce the cumulative antigen produced over the course of an infection. PMID:26664946

Dynamics of Parascaris and Strongylus spp. parasites in untreated juvenile horses.

PubMed

Fabiani, J V; Lyons, E T; Nielsen, M K

2016-10-30

Parasite control in foals is of utmost importance due to the high susceptibility to parasitic infection and disease in this age group. Foals are commonly co-infected with strongyle and ascarid parasites, which complicate parasite control strategies. The present study retrospectively investigated necropsy records of foals born into a university herd kept without anthelmintic treatment since 1979. The aims were to statistically analyze the relationship between fecal egg counts, worm burdens, foal age, sex, and season with specific focus on Parascaris and Strongylus spp. A total of 83 foals born between 1999 and 2015 were included. Foals were born between January and September within the given year and age at necropsy ranged between 27 and 563 days of age with a mean and median of 202 and 204 days, respectively. One set of multivariate mixed linear models was constructed analyzing strongyle and ascarid fecal egg counts as outcome variables, and another set of analyses investigated the following worm counts as outcome variables: Intestinal Parascaris spp. counts (immatures and adults), S. vulgaris (migrating and intestinal stages), S. edentatus (migrating and intestinal stages). Both ascarid and strongyle egg counts were influenced significantly by differences between study years (p<0.05). In addition, total ascarid egg counts were statistically influenced by age (p=0.020) exhibiting a peak at four months of age and fillies had significantly higher ascarid worm burdens (p=0.043). Foal age had significant influences on intestinal counts of immature Parascaris spp. (p=0.034) and adult S. edentatus counts (p=0.028). Larval counts of S. edentatus were significantly associated with birth month (p=0.023), whereas counts of migrating S. vulgaris larvae were not statistically associated with any of the investigated covariates. This study provides novel information on the dynamics of important parasites in naturally infected foals. Copyright © 2016 Elsevier B.V. All rights reserved.

Evidence of host adaptation in Lawsonia intracellularis infections

PubMed Central

2012-01-01

Background Lawsonia intracellularis is the causative agent of proliferative enteropathy, an endemic disease in pigs and an emerging concern in horses. Enterocyte hyperplasia is a common lesion in every case but there are differences regarding clinical and pathological presentations among affected species. We hypothesize that host susceptibility to L. intracellularis infection depends on the species of origin of the bacterial isolate. The objective of this study was to evaluate the susceptibilities of pigs and horses to L. intracellularis infection using either a porcine or an equine isolate. Materials and methods Twelve foals and eighteen pigs were equally divided into three groups and infected with either a porcine or an equine isolate (109L. Intracellularis/challenged animal), and a saline solution (negative control group). The animals were monitored regarding clinical signs, average of daily weight gain, fecal shedding of the bacteria by PCR and humoral serological response. Results Foals infected with the equine isolate developed moderate to severe clinical signs and maintained a lower average of weight gain compared to control foals. Fecal quantitative PCR in equine isolate-infected foals revealed higher amounts of bacterial DNA associated with longer duration of shedding compared with porcine isolate-infected foals. All four foals infected with the equine isolate demonstrated higher IgG titers in the serum compared with porcine isolate-infected foals. In the pig trial, diarrhea and seroconversion were only observed in animals infected with the porcine isolate. Pathological changes typical of proliferative enteropathy were observed in the necropsied foal infected with equine isolate and in the two necropsied pigs infected with the porcine isolate. Conclusions Evident clinical signs, longer periods of bacterial shedding and stronger serologic immune responses were observed in animals infected with species-specific isolates. These results show that host susceptibility is driven by the origin of the isolated L. intracellularis strain. PMID:22715937

Effects of Surface Structure and of Embedded-Atom Pair Functionals on Adatom Diffusion on FCC Metallic Surfaces

DTIC Science & Technology

1992-11-01

total-energy calculations that this complex mechanism for diffusion can be invoked for surface self-diffusion on the (100) surface ( Kellog and...Woodland Hills, CA 91364 National Science Foundation 3 SRI International ATIN: A.B. Harvey ATIN: G. Smith Washington, DC 20550 D. Crosley D. Golden...Aeronautics and Astronautics ATTN: H. Krier ATfN: J.R. Osborn 144MEB, 1206 W. Green St. Grissom Hall Urbana, IL 61801 West Lafayette, IN 47906 The Johns

Leaders break ground for INFINITY

NASA Image and Video Library

2008-11-20

Community leaders from Mississippi and Louisiana break ground for the new INFINITY at NASA Stennis Space Center facility during a Nov. 20 ceremony. Groundbreaking participants included (l to r): Gottfried Construction representative John Smith, Mississippi Highway Commissioner Wayne Brown, INFINITY board member and Apollo 13 astronaut Fred Haise, Stennis Director Gene Goldman, Studio South representative David Hardy, Leo Seal Jr. family representative Virginia Wagner, Hancock Bank President George Schloegel, Mississippi Rep. J.P. Compretta, Mississippi Band of Choctaw Indians representative Charlie Benn and Louisiana Sen. A.G. Crowe.

Suspected ivermectin toxicosis in a miniature mule foal causing blindness.

PubMed

Plummer, Caryn E; Kallberg, Maria E; Ollivier, Franck J; Brooks, Dennis E; Gelatt, Kirk N

2006-01-01

A 9-week-old miniature mule foal presented to the Veterinary Medical Teaching Hospital for acute blindness, ataxia, and depression following an overdose of an over-the-counter ivermectin-based de-worming medication. Ophthalmic examination and electrodiagnostic evaluation eliminated outer retinal abnormalities as the primary cause of the bilateral blindness, implicating instead a central neurologic effect of the drug. With symptomatic and supportive care, the foal recovered fully and regained its vision.

Interactions between Artificial Gravity, Affected Physiological Systems, and Nutrition

NASA Technical Reports Server (NTRS)

Heer, Martina; Baecker, Natalie; Zwart, Sara; Smith, Scott M.

2007-01-01

Malnutrition, either by insufficient supply of some nutrients or by overfeeding has a profound effect on the health of an organism. Therefore, optimal nutrition is mandatory on Earth (1 g), in microgravity and also when applying artificial gravity to the human system. Immobilization like in microgravity or bed rest also has a profound effect on different physiological systems, like body fluid regulation, the cardiovascular, the musculoskeletal, the immunological system and others. Up to now there is no countermeasure available which is effective to counteract cardiovascular deconditioning (rf. Chapter 5) together with maintenance of the musculoskeletal system in a rather short period of time. Gravity seems therefore to be one of the main stimuli to keep these systems and application of certain duration of artificial gravity per day by centrifugation has often been proposed as a very potential countermeasure against the weakening of the physiological systems. Up to now, neither optimal intensity nor optimal length of application of artificial gravity has been studied sufficiently to recommend a certain, effective and efficient protocol. However, as shown in chapter 5 on cardiovascular system, in chapter 6 on the neuromuscular system and chapter 7 (bone and connective system) artificial gravity has a very high potential to counteract any degradation caused by immobilization. But, nutrient supply -which ideally should match the actual needs- will interact with these changes and therefore has also to be taken into account. It is well known that astronauts beside the Skylab missions- were and are still not optimally nourished during their stay in space (Bourland et al. 2000;Heer et al. 1995;Heer et al. 2000b;Smith et al. 1997;Smith & Lane 1999;Smith et al. 2001;Smith et al. 2005). It has also been described anecdotally that astronauts have lower appetites. One possible explanation could be altered taste and smell sensations during space flight, although in some early space flights no significant changes were found (Heidelbaugh et al. 1968;Watt et al. 1985). However, data from a recent head-down bed rest study showed significant decrease in smell sensation (Enck et al. unpublished data) suggesting that fluid shifts might have an impact. If this holds true and which has to be validated in further studies, this seems to play an important role for lowered food intake causing insufficient energy intake and subsequently insufficient supply of most of the macro- and micronutrients. Other nutrients are taken in excess, for example sodium. As it is very well known from daily food consumption especially premanufactured food with high salt content seems to be more palatable than that with low salt content. Salt also functions as preservation which is very important taking into account the space food system limitations (i.e., lack of refrigerators and freezers). The preference for food with high salt intake by astronauts might therefore very likely be caused by altered smell and taste sensations in microgravity.

Effects of inbreeding and other systematic effects on fertility of Black Forest Draught horses in Germany.

PubMed

Müller-Unterberg, Maarit; Wallmann, Sandra; Distl, Ottmar

2017-10-18

The Black Forest Draught horse (BFDH) is an endangered German coldblood breed with its origin in the area of the Black Forest in South Germany. In this retrospective study, the influence of the inbreeding coefficient on foaling rates was investigated using records from ten breeding seasons. Due to the small population size of BFDH, the level of inbreeding is increasing and may have an effect on foaling rates.The data of the present study included all coverings reported for 1024 BFDH mares in the years 2001-2009. These mares were covered by 32 BFDH stallions from the State Stud Marbach. Data from 4534 estrus cycles was used to calculate per cycle foaling rate (CFR). Pedigree data contained all studbook data up to the foundation of the breed as early as 1836. The level of inbreeding of the mare, stallion and expected foal along with other systematic effects on CFR were analysed using a generalized linear mixed model approach. Stallion was employed as a random effect. Systematic fixed effects were month of mating, mating type, age of the mare and stallion, reproductive status of the mare and stallion line of the mare. Inbreeding coefficients of the stallion, mare and expected foal were modelled as linear covariates. The average CFR was 40.9%. The mean inbreeding coefficients of the mares, stallions and expected foals were 7.46, 7.70 and 9.66%. Mating type, age of the mare, reproductive status of the mare and stallion line of the mare had a significant effect. The results showed that the mating type, stallion line of the mare, sire, age and reproductive status of the mare exerted the largest influences on CFR in BFDH. Inbreeding coefficients of the stallion, mare and expected foal were not significantly related with CFR.

Effects of maternal dexamethasone treatment on pancreatic β cell function in the pregnant mare and post natal foal.

PubMed

Valenzuela, O A; Jellyman, J K; Allen, V L; Holdstock, N B; Fowden, A L

2017-01-01

Synthetic glucocorticoids are used to treat inflammatory conditions in horses. In other pregnant animals, glucocorticoids are given to stimulate fetal maturation with long-term metabolic consequences for the offspring if given preterm. However, their metabolic effects during equine pregnancy remain unknown. Thus, this study investigated the metabolic effects of dexamethasone administration on pregnant pony mares and their foals after birth. Experimental study. A total of 3 doses of dexamethasone (200 μg/kg bwt i.m.) were given to 6 pony mares at 48 h intervals beginning at ≈270 days of pregnancy. Control saline injections were given to 5 mares using the same protocol. After fasting overnight, pancreatic β cell responses to exogenous glucose were measured in the mares before, during and after treatment. After birth, pancreatic β cell responses to exogenous glucose and arginine were measured in the foals at 2 and 12 weeks. In mares during treatment, dexamethasone but not saline increased basal insulin concentrations and prolonged the insulin response to exogenous glucose. Basal insulin and glucose concentrations still differed significantly between the 2 groups 72 h post treatment. Dexamethasone treatment significantly reduced placental area but had little effect on foal biometry at birth or subsequently. Foal β cell function at 2 weeks was unaffected by maternal treatment. However, by 12 weeks, pancreatic β cell sensitivity to arginine, but not glucose, was less in foals delivered by dexamethasone- than saline-treated mares. Dexamethasone administration induced changes in maternal insulin-glucose dynamics, indicative of insulin resistance and had subtle longer term effects on post natal β cell function of the foals. The programming effects of dexamethasone in horses may be mediated partially by altered maternal metabolism and placental growth. © 2016 EVJ Ltd.

Relationship between the Placental Retention Time and the Reproductive Performance at the Foal Heat in Thoroughbred and a Comparison with Heavy Draft

PubMed Central

ISHII, Mitsuo; AOKI, Takahiro; YAMAKAWA, Kazuhiro; MAGATA, Fumie; GOJO, Chikara; ITO, Katsumi; KAYANO, Mitsunori; NAMBO, Yasuo

2013-01-01

The aim of this study was to clarify the relationship between the placental retention time (PRT) and the reproductive performance following mating at the foal heat in Thoroughbreds. For this purpose, we interviewed 292 farmers over a period of 3 years with questionnaires evaluating foaling, expulsion of placenta and reproductive performance at the foal heat in 1,432 mares. The obtained data were later compared with a previous study of heavy draft mares. The average of the PRT of the 1,432 Thoroughbred mares was 58 ± 88 min (mean ± SD). The mean PRT of Thoroughbreds was significantly shorter than that of the148 min of heavy draft mares. The incidences of retained placenta (RP) occurring in the Thoroughbred mares were 5.2 and 4.0%, for over 3 and 4 hr after foaling, respectively. The incidence of RP over 4 hr was significantly lower than that of 25% in heavy draft mares. The pregnancy rate at foal heat of the mares in which PRT was less than 3 hr was 37%, and it significantly decreased to 11% for those with PRT of more than 3 hr. In the comparison of the reproductive performance between Thoroughbred and heavy draft mares, the pregnancy rate of Thoroughbreds dropped drastically to 10% when PRT exceeded 40, and in consequence, the pregnancy rate of Thoroughbreds was significantly lower than the 30% of heavy draft mares, which had a PRT of over 4 hr. In conclusion, the Thoroughbred mares had a low incidence of RP, however, a PRT exceeding 3 hr severely affected the reproductive performance at the foal heat. PMID:24833998

Relationship between the Placental Retention Time and the Reproductive Performance at the Foal Heat in Thoroughbred and a Comparison with Heavy Draft.

PubMed

Ishii, Mitsuo; Aoki, Takahiro; Yamakawa, Kazuhiro; Magata, Fumie; Gojo, Chikara; Ito, Katsumi; Kayano, Mitsunori; Nambo, Yasuo

2013-01-01

The aim of this study was to clarify the relationship between the placental retention time (PRT) and the reproductive performance following mating at the foal heat in Thoroughbreds. For this purpose, we interviewed 292 farmers over a period of 3 years with questionnaires evaluating foaling, expulsion of placenta and reproductive performance at the foal heat in 1,432 mares. The obtained data were later compared with a previous study of heavy draft mares. The average of the PRT of the 1,432 Thoroughbred mares was 58 ± 88 min (mean ± SD). The mean PRT of Thoroughbreds was significantly shorter than that of the148 min of heavy draft mares. The incidences of retained placenta (RP) occurring in the Thoroughbred mares were 5.2 and 4.0%, for over 3 and 4 hr after foaling, respectively. The incidence of RP over 4 hr was significantly lower than that of 25% in heavy draft mares. The pregnancy rate at foal heat of the mares in which PRT was less than 3 hr was 37%, and it significantly decreased to 11% for those with PRT of more than 3 hr. In the comparison of the reproductive performance between Thoroughbred and heavy draft mares, the pregnancy rate of Thoroughbreds dropped drastically to 10% when PRT exceeded 40, and in consequence, the pregnancy rate of Thoroughbreds was significantly lower than the 30% of heavy draft mares, which had a PRT of over 4 hr. In conclusion, the Thoroughbred mares had a low incidence of RP, however, a PRT exceeding 3 hr severely affected the reproductive performance at the foal heat.

Equine goiter associated with excess dietary iodine.

PubMed

Eroksuz, H; Eroksuz, Y; Ozer, H; Ceribasi, A O; Yaman, I; Ilhan, N

2004-06-01

Naturally occurring goiter cases are described in 2 newborn Arabian foals whose mares were supplemented with excess iodine during the final 24 w of the pregnancy. Six nursing foals and 2 mares were also affected clinically with thyroid hypertrophy. At least 12 times the maximum tolerable level of iodine supplementation was given, as the daily iodine intake for each mare was 299 mg. The prevalence of goiter cases was 2 and 9% in the mares and foals, respectively.

Effectiveness of fenbendazole against later 4th-stage Strongylus vulgaris in ponies.

PubMed

Slocombe, J O; McCraw, B M; Pennock, P W; Baird, J D

1983-12-01

Twelve pony foals (reared worm-free) were inoculated with Strongylus vulgaris. Approximately 8 weeks later, 4 of the foals were given fenbendazole (10% suspension) at a dosage rate of 10 mg/kg of body weight daily for 5 days and 4 foals were given the suspension at a dosage rate of 50 mg/kg daily for 3 days; the remaining foals were given a placebo. All treatments were administered by stomach tube. Fenbendazole was 99.6 and 97.9% effective in the 2 treatment groups, respectively, in eliminating later 4th-stage S vulgaris larvae located near the origin of major intestinal arteries. On microscopic examination of the ileocolic artery from fenbendazole-treated foals, a few larval remnants were found beneath the tunica intima in small organized mural thrombi overgrown with endothelium. It would appear that larvae are rapidly destroyed after administration of fenbendazole. A pony foal reared on pasture and with arteriographic evidence of arteritis of the cranial mesenteric and ileocolic arteries was treated with fenbendazole (10% suspension) by stomach tube at a dosage rate of 50 mg/kg of body weight daily for 3 days. By arteriographic examination made 4 weeks later, there was evidence of regression of the lesion, and at necropsy done a week later, there was no arteritis or larvae in the lumen of those arteries.

Effect of linseed supplementation and slaughter age on meat quality of grazing cross-bred Galician x Burguete foals.

PubMed

Domínguez, Rubén; Pateiro, Mirian; Crecente, Santiago; Ruiz, Marta; Sarriés, María V; Lorenzo, José M

2018-01-01

The aim of this study was to assess the effect of finishing diet (control concentrate vs. linseed concentrate) and slaughter age (13 vs. 26 months) on meat and nutritional quality of foal meat. For this study, 46 foals from crossing Galicia Mountain x Burguete breeds were used. The obtained results showed that slaughter age had an influence on chemical composition and colour parameters. Foals slaughtered at the age of 13 months had lower content of intramuscular fat and higher cholesterol contents than those slaughtered at 26 months of age. Regarding colour parameters, older foals showed the highest values of redness and lowest myoglobin contents. Finishing diet had a low effect on the majority of parameters evaluated. Foals fed with linseed presented lower shear force values than those fed with control concentrate. Fatty acid and amino acid contents were hardly influenced by finishing diet, whereas slaughter age effect had a high impact on fatty acid profile. Older animals showed lowest SFA values and n-6/n-3 ratio. Older animals presented the best meat quality. Diet had low effect in meat quality and could be related to the short time during finishing diet was administered and the low amount of linseed in the experimental diet. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010).

PubMed

Lyons, Eugene T; Tolliver, Sharon C; Kuzmina, Tetiana A; Collins, Sandra S

2011-10-01

The activity of three anthelmintics (fenbendazole-FBZ; oxibendazole-OBZ; and pyrantel pamoate-PRT) was ascertained against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010) in field tests. A total of 316 foals were treated, and 168 (53.2%) were passing ascarid eggs on the day of treatment. Evaluation of drug efficacy was determined qualitatively by comparing the number of foals passing ascarid eggs in their feces before and after treatment. The main purpose was to obtain data on current activity of these compounds against ascarids. Additionally, the objective was to compare these findings with those from earlier data on the efficacy of these three compounds on nematodes in foals in this geographical area. Efficacies (average) for the foals ranged for FBZ (10 mg/kg) from 50% to 100% (80%), for OBZ (10 mg/kg) from 75% to 100% (97%), and for PRT at 1× (6.6 mg base/kg) from 0% to 71% (2%) and at 2× (13.2 mg base/kg) 0% to 0% (0%). Although the efficacy varied among the drugs, combined data for all farms indicated a significant reduction of ascarid infections for FBZ (p < 0.0001) and OBZ (p < 0.0001) but not for PRT (p = 0.0953).

Effect of slaughter age and feeding system on the neutral and polar lipid composition of horse meat.

PubMed

Belaunzaran, X; Lavín, P; Mantecón, A R; Kramer, J K G; Aldai, N

2018-02-01

This study was undertaken to provide a thorough analysis of the neutral lipid (NL) and polar lipid (PL) fractions of horse meat that included the content and distribution of acyl and alkenyl moieties in foals under different rearing conditions. Two groups of crossbred horses were studied; the first group was selected from suckling foals produced under grazing conditions and slaughtered at 4 months of age (n=8), and the second group was selected from concentrate-finished foals and slaughtered at 12 months of age (n=7). There were significant differences related to the age and feeding practices of foals which affected the intramuscular (IM) fat content and the fatty acid (FA) composition of NL and PL fractions. Samples from suckling foals were leaner and provided the highest content of methylation products from the plasmalogenic lipids, and total and n-3 polyunsaturated fatty acid (PUFA). By contrast, the meat from concentrate-finished foals had a higher IM fat level resulting in a greater accumulation of 16:0 and total monounsaturated FAs in the NL fraction, whereas the muscle PL fraction retained a similar FA composition between both groups. Linolenic acid was preferentially deposited in the NL fraction, but linoleic acid and the long-chain n-3 and n-6 PUFAs were incorporated into the PL fraction where they served as cell membrane constituents and in eicosanoid formation.

Hypercapnic respiratory acidosis: a protective or harmful strategy for critically ill newborn foals?

PubMed

Vengust, Modest

2012-10-01

This paper reviews both the beneficial and adverse effects of permissive hypercapnic respiratory acidosis in critically ill newborn foals. It has been shown that partial carbon dioxide pressure (PCO2) above the traditional safe range (hypercapnia), has beneficial effects on the physiology of the respiratory, cardiovascular, and nervous system in neonates. In human neonatal critical care medicine permissive hypercapnic acidosis is generally well-tolerated by patients and is more beneficial to their wellbeing than normal carbon dioxide (CO2) pressure or normocapnia. Even though adverse effects of hypercapnia have been reported, especially in patients with central nervous system pathology and/or chronic infection, critical care clinicians often artificially increase PCO2 to take advantage of its positive effects on compromised neonate tissues. This is referred to as therapeutic hypercapnia. Hypercapnic respiratory acidosis is common in critically ill newborn foals and has traditionally been considered as not beneficial. A search of online scientific databases was conducted to survey the literature on the effects of hypercapnia in neonates, with emphasis on newborn foals. The dynamic status of safety levels of PCO2 and data on the effectiveness of different carbon dioxide levels are not available for newborn foals and should be scientifically determined. Presently, permissive hypercapnia should be implemented or tolerated cautiously in compromised newborn foals and its use should be based on relevant data from adult horses and other species.

Cholesterol oxidase (ChoE) is not important in the virulence of Rhodococcus equi.

PubMed

Pei, Yanlong; Dupont, Chris; Sydor, Tobias; Haas, Albert; Prescott, John F

2006-12-20

To analyze further the role in virulence of the prominent cholesterol oxidase (ChoE) of Rhodococcus equi, an allelic exchange choE mutant from strain 103+ was constructed and assessed for virulence in macrophages, in mice, and in foals. There was no difference between the mutant and parent strain in cytotoxic activity for macrophages or in intra-macrophage multiplication. No evidence of attenuation was obtained in macrophages and in mice, but there was slight attenuation apparent in four intra-bronchially infected foals compared to infection of four foals with the virulent parent strain, based on a delayed rise in temperature of the choE-mutant infected foals. However, bacterial colony counts in the lung 2 weeks after infection were not significantly different, although there was a slight but non-significant (P=0.12) difference in lung:body weight ratio of the choE mutant versus virulent parent infected foals (mean 2.67+/-0.25% compared to 4.58+/-0.96%). We conclude that the cholesterol oxidase is not important for the virulence of R. equi.

Inter-birth interval in zebras is longer following the birth of male foals than after female foals

NASA Astrophysics Data System (ADS)

Barnier, Florian; Grange, Sophie; Ganswindt, Andre; Ncube, Hlengisizwe; Duncan, Patrick

2012-07-01

Mammalian reproductive rates vary among individuals for physiological and environmental reasons. This study aims to determine reproductive rates from an individually monitored population of wild Plains zebras Equus quagga, and to assess the sources of variability in inter-birth intervals. The animals were monitored, where possible, every six months from 2004 to 2011. Thirty nine intervals corresponding to 65 births in 26 mares were identified, using direct observations and faecal steroid monitoring. Mean foaling rate of the population is 0.74 foal/year, and comparable with the literature. There was no significant effect of mother's age, nor of the season of previous birth on the length of inter-birth intervals. Inter-birth interval was significantly longer when the first foal was a male. This finding indicates that additional costs of having a son may delay future reproduction and thus reduce the total number of offspring a mare can have during her lifetime. Individually-based data provide critical information on the determinants of reproductive rates, and are therefore a key to understanding the causes of variations in life-history traits.

Reduced Gravity Walking Simulator

NASA Image and Video Library

1964-06-20

A "suited" test subject on the Reduced Gravity Walking Simulator located in the hanger at Langley Research Center. The initial version of this simulator was located inside the hanger. Later a larger version would be located at the Lunar Landing Facility. The purpose of this simulator was to study the subject while walking, jumping or running. Researchers conducted studies of various factors such as fatigue limit, energy expenditure, and speed of locomotion. Francis B. Smith wrote in "Simulators For Manned Space Research:" "The cables which support the astronaut are supported by an overhead trolley about 150 feet above the center line of the walkway and the support is arranged so that the subject is free to walk, run, jump, and perform other self-locomotive tasks in a more-or-less normal manner, even though he is constrained to move in one place." "The studies thus far show that an astronaut should have no particular difficulty in walking in a pressurized space suit on a hard lunar surface. Rather, the pace was faster and the suit was found to be more comfortable and less fatiguing under lunar "g" than under earth "g." When the test subject wished to travel hurriedly any appreciable distance, a long loping gait at about 10 feet per second was found to be most comfortable." -- Published in James R. Hansen, Spaceflight Revolution: NASA Langley Research Center From Sputnik to Apollo, (Washington: NASA, 1995), p. 377; Francis B. Smith, "Simulators For Manned Space Research," Paper for 1966 IEEE International Convention, New York, NY, March 21-25, 1966.

The STS-103 crew with loved ones at Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

The STS-103 crew pose for photographers with their loved ones at Launch Pad 39B. Space Shuttle Discovery is in the background, next to the Fixed Service Structure lit up like a Christmas tree. Viewed left to right are Mission Specialist Steven L. Smith and his wife, Peggy; Pilot Scott J. Kelly and his wife, Leslie; Commander Curtis L. Brown Jr. and his fiancee, Ann Brickert; Mission Specialist C. Michael Foale; Laurence Clervoy and her husband, Mission Specialist Jean-Frangois Clervoy; Mission Specialist John M. Grunsfeld and his wife, Carol; Mission Specialist Claude Nicollier and his wife, Susana. Nicollier and Clervoy are with the European Space Agency. The mission, to service the Hubble Space Telescope, is scheduled for launch Dec. 17 at 8:47 p.m. EST from Launch Pad 39B. Mission objectives include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. The mission is expected to last about 8 days and 21 hours. Discovery is expected to land at KSC Sunday, Dec. 26, at about 6:25 p.m. EST.

Advances in Diagnostics and Treatments in Horses and Foals with Gastric and Duodenal Ulcers.

PubMed

Camacho-Luna, Pilar; Buchanan, Benjamin; Andrews, Frank M

2018-04-01

Equine gastric ulcer syndrome (EGUS) primarily describes ulceration in the terminal esophagus, nonglandular squamous mucosa, glandular mucosa of the stomach, and proximal duodenum. EGUS is common in all breeds and ages of horses and foals. This article focuses on the current terminology for EGUS, etiologies and pathogenesis for lesions in the nonglandular and glandular stomach, diagnosis, and a comprehensive approach to the treatment and prevention of EGUS in adult horses and foals. Copyright © 2017 Elsevier Inc. All rights reserved.

STS-45 MS Foale dons EMU with technicians' help in JSC's WETF Bldg 29

NASA Technical Reports Server (NTRS)

1991-01-01

STS-45 Atlantis, Orbiter Vehicle (OV) 104, Mission Specialist (MS) C. Michael Foale stands on a platform as technicians help him don his extravehicular mobility unit (EMU). The technicians are preparing to connect the EMU upper and lower torsos at the waist ring. When fully suited, Foale will be lowered into a nearby 25 ft deep pool for an underwater simulation of contingency extravehicular activity (EVA) procedures. The pool is located in JSC's Weightless Environment Training Facility (WETF) Bldg 29.

Mare and foal survival and subsequent fertility of mares treated for uterine torsion.

PubMed

Spoormakers, T J P; Graat, E A M; ter Braake, F; Stout, T A E; Bergman, H J

2016-03-01

Previous surveys have reported that mare and foal survival after correction of uterine torsion (UT) varies from 60 to 84% and from 30 to 54%, respectively. Furthermore, resolution via a standing flank laparotomy (SFL) has been associated with better foal, but not mare, survival. To compare the success of SFL with other correction methods (e.g. midline or flank laparotomy under general anaesthesia; correction per vaginam). Retrospective analysis of clinical records. Data on correction technique, stage of gestation, degree of rotation, survival and subsequent fertility for 189 mares treated for UT at 3 equine referral hospitals in The Netherlands during 1987-2007 were analysed. Mean stage of gestation at diagnosis was 283 days (range 153-369 days), with the majority of UTs (77.5%) occurring before Day 320 of gestation. After correction of UT, 90.5% of mares and 82.3% of foals survived to hospital discharge, between 3 and 39 days later, and to foaling. Multivariable logistic regression indicated that correction method and stage of gestation at UT affected survival of foals and mares. For foals, survival was 88.7% after SFL compared with 35.0% after other methods (P = 0.001). When UT occurred at <320 days, 90.6% of foals survived, compared with 56.1% at ≥320 days (P = 0.007). For mare survival, an interaction between stage of gestation and correction method was detected (P = 0.02), with higher survival after SFL (97.1%) than other methods (50.0%) at <320 days of gestation (P<0.01). When UT occurred at ≥320 days, mare survival did not differ between techniques (76.0 vs. 68.8%; P = 0.6). Of 123 mares that were bred again, 93.5% became pregnant; fertility did not differ between mares treated by SFL (93.9%) and other techniques (87.5%; P = 0.9). Standing flank laparotomy is the surgical technique of choice for resolving uncomplicated equine UT (i.e. with no coexisting gastrointestinal lesions) except when the stage of gestation exceeds 320 days. © 2015 EVJ Ltd.

HORSE SPECIES SYMPOSIUM: Nutritional programming and the impact on mare and foal performance.

PubMed

Coverdale, J A; Hammer, C J; Walter, K W

2015-07-01

Many environmental factors can alter the phenotype of offspring when applied during critical periods of early development. In most domestic species, maternal nutrition influences fetal development and the fetus is sensitive to the nutrition of the dam during pregnancy. Many experimental models have been explored including both under- and overnutrition of the dam. Both nutritional strategies have yielded potential consequences including altered glucose tolerance, pancreatic endocrine function, insulin sensitivity, body composition, and colostrum quality. Although the impact of maternal nutrition on fetal development in the equine has not been thoroughly investigated, overnutrition is a common occurrence in the industry. Work in our laboratory has focused on effects of maternal overnutrition on mare and foal performance, mare DMI, foaling parameters, colostrum quality and passive transfer of immunity, and glucose and insulin dynamics. Over several trials, mares were fed either 100 or 140% of NRC requirements for DE, and supplemental Se and arginine were added to diets in an attempt to mitigate potential intrauterine growth retardation resulting from dams overfed during the last third of pregnancy. As expected, when mares were overfed, BW, BCS, and rump fat values increased. Foal growth over 150 d was also not influenced. Maternal nutrition did not alter colostrum volume but influenced colostrum quality. Maternal overnutrition resulted in lower colostrum IgG concentrations but did not cause failure of passive transfer in foals. Supplemental Se and arginine were unable to mitigate this reduction in colostrum IgG. Additionally, mare and foal glucose and insulin dynamics were influenced by maternal nutrition. Mare glucose and insulin area under the curve (AUC) increased with increased concentrate supplementation. Foal insulin AUC and peak insulin concentrations were increased when mares were fed concentrate and, in a later trial, foal peak glucose values were reduced with arginine supplementation of the mare. This influence of maternal nutrition on glucose and insulin dynamics warrants further investigation because it may be related to athletic performance and metabolic disease in the adult. Further studies will be necessary to fully elucidate the influence of mare nutrition during pregnancy on development of the fetus as well as long-term consequences of developmental programming.

GRC-2010-C-00452

NASA Image and Video Library

2006-02-02

From Space to the Super Bowl Members of the STS-129 shuttle mission present a specially minted silver medallion to National Football League officials on Wednesday, Jan. 27, 2010, at the Pro Football Hall of Fame in Canton, Ohio. The coin, which was flown in space during the November flight of Atlantis, will be used for the official coin toss prior to the kickoff of Super Bowl XLIV on Sunday, Feb. 7, 2010. One member of Atlantis' crew, Leland Melvin, was drafted by the NFL's Detroit Lions in 1986. The crew also flew other NFL-related memorabilia, including jerseys and a football inscribed with the name of every member of the Hall of Fame. From left: Astronauts Bobby Satcher, Randy Bresnik, and Charlie Hobaugh; Joe Horrigan, Vice President of Communications/Exhibits for the Pro Football Hall of Fame, Steve Perry, President/Executive Director of the Pro Football Hall of Fame; astronauts Berry Wilmore, Michael Foreman and Leland Melvin. Photo Credit: NASA/Marv Smith

Quantitative Analysis and Development of the Fore Feet of Arabian Foals from Birth to 1 Year of Age.

PubMed

Faramarzi, Babak; Salinger, Allison; Kaneps, Andris; Nout-Lomas, Yvette; Greene, Holly; Dong, Fanglong

2017-11-01

Objectives  The goal of this study was to quantify external and internal anatomical characteristics of the foal foot throughout the first year of age. Methods  Digital radiographs and photographs were taken bimonthly of the forefeet of nine Arabian foals, beginning at about 2 weeks of age until 12 months of age. Sixty-eight linear and angular variables were measured using NIH (National Institutes of Health) Image J software. Statistical analyses were performed using piecewise random coefficient model and p -values < 0.05 were considered significant. Results  Distinct changes in hoof development were identified between 4 and 8 months of age. Distinct changes were identified in several external (conformational) measurements including hoof solar widths and lengths, palmar heel lengths, toe and heel angles and in several internal (radiographic) measurements including the widths and lengths of the phalanges and sesamoid bones as well as joint angles. Clinical Significance  Existing knowledge of distal limb development in foals, particularly the foot, is limited. These findings define the measurable changes of the foal foot as it grows during the first year of life. These data provide an insight into the transformation of the hoof from its initial oval to a circular shape and from a club-like, cylindrical conformation to a more angled, conical conformation. This paper quantifies this development, ultimately allowing a better understanding of morphological changes in the foot of the growing foal. Schattauer GmbH Stuttgart.

STS-103 crew practice emergency egress in the slidewire basket

NASA Technical Reports Server (NTRS)

1999-01-01

In the slidewire basket on Launch Pad 39B, STS-103 Mission Specialist C. Michael Foale (Ph.D.) gets ready to pull the lever, which will release the basket. With Foale are fellow crew members Mission Specialists Claude Nicollier of Switzerland and John M. Grunsfeld (Ph.D.). The baskets are part of the emergency egress system for persons in the Shuttle vehicle or on the Rotating Service Structure. Seven slidewires extend from the orbiter access arm, with a netted, flatbottom basket suspended from each wire. The STS-103 crew are taking part in Terminal Countdown Demonstration Test (TCDT) activities in preparation for launch. The other crew members taking part are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, and Jean-Frangois Clervoy of France. Clervoy and Nicollier are with the European Space Agency. The TCDT provides the crew with the emergency egress training, opportunities to inspect their mission payloads in the orbiter's payload bay, and simulated countdown exercises. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

KSC-97PC841

NASA Image and Video Library

1997-05-24

The orbiter drag chute deploys after Atlantis touches down on Runway 33 of KSC’s Shuttle Landing Facility at the conclusion of the nine-day STS-84 mission. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

KSC-97PC850

NASA Image and Video Library

1997-05-24

The orbiter drag chute deploys after Atlantis touches down on Runway 33 of KSC’s Shuttle Landing Facility at the conclusion of the nine-day STS-84 mission. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

KSC-97PC842

NASA Image and Video Library

1997-05-24

The orbiter drag chute deploys after Atlantis touches down on Runway 33 of KSC’s Shuttle Landing Facility at the conclusion of the nine-day STS-84 mission. Main gear touchdown was at 9:27:44 EDT on May 24, 1997. The first landing opportunity was waved off because of low cloud cover. It was the 37th landing at KSC since the Shuttle program began in 1981, and the eighth consecutive landing at KSC. STS-84 was the sixth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. Atlantis was docked with the Mir for five days. STS-84 Mission Specialist C. Michael Foale replaced astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger returned to Earth on Atlantis with the rest of the STS-84 crew, Mission Commander Charles J. Precourt, Pilot Eileen Marie Collins, and Mission Specialists Carlos I. Noriega, Edward Tsang Lu, Elena V. Kondakova of the Russian Space Agency and JeanFrancois Clervoy of the European Space Agency. Foale is scheduled to remain on the Mir for approximately four months, until he is replaced by STS-86 crew member Wendy B. Lawrence in September. Besides the docking and crew exchange, STS-84 included the transfer of more than 7,300 pounds of water, logistics and science experiments and hardware to and from the Mir. Scientific experiments conducted during the STS-84 mission, and scheduled for Foale’s stay on the Mir, are in the fields of advanced technology, Earth sciences, fundamental biology, human life sciences, International Space Station risk mitigation, microgravity sciences and space sciences

Stennis Space Center observes 2009 Safety and Health Day

NASA Technical Reports Server (NTRS)

2009-01-01

Sue Smith, a medical clinic employee at NASA's John C. Stennis Space Center, takes the temperature of colleague Karen Badon during 2009 Safety and Health Day activities Oct. 22. Safety Day activities included speakers, informational sessions and a number of displays on safety and health issues. Astronaut Dominic Gorie also visited the south Mississippi rocket engine testing facility during the day to address employees and present several Silver Snoopy awards for outstanding contributions to flight safety and mission success. The activities were part of an ongoing safety and health emphasis at Stennis.

KSC-97pc276

NASA Image and Video Library

1997-02-11

STS-82 Mission Commander Kenneth D. Bowersox leads the way to the astronaut van as the crew departs from the Operations and Checkout Building en route to Launch Pad 39A, where the Space Shuttle Discovery awaits liftoff on a 10-day mission to service the Hubble Space Telescope (HST). Directly behind him is Pilot Scott J. "Doc" Horowitz. The other five crew members, clockwise from left, are Mission Specialist Steven L. Smith, Payload Commander Mark C. Lee, and Mission Specialists Steven A. Hawley, Gregory J. Harbaugh and Joseph R. "Joe" Tanner

Shuttle Atlantis on approach for docking to the ISS during STS-110 and Expedition Four

NASA Image and Video Library

2002-04-10

ISS004-E-9944 (10 April 2002) --- The Space Shuttle Atlantis prepares to dock with the International Space Station (ISS) during the STS-110 mission. Aboard Atlantis are astronauts Michael J. Bloomfield, mission commander; Stephen N. Frick, pilot; Rex J. Walheim, Ellen Ochoa, Lee M. E. Morin, Jerry L. Ross, and Steven L. Smith, all mission specialists. The STS-110 crewmembers are delivering the S0 (S-zero) truss, which is visible in Atlantis’ payload bay. This image was taken by an Expedition Four crewmember.

EVA 5 activity on Flight Day 8 to service the Hubble Space Telescope

NASA Image and Video Library

1997-02-18

S82-E-5718 (18 Feb. 1997) --- Making use of the Remote Manipulator System (RMS) astronauts Mark C. Lee (left), STS-82 payload commander, and Steven L. Smith, mission specialist, perform the final phases of Extravehicular Activity (EVA) duty. Lee holds a patch piece for Bay #10, out of view, toward which the two were headed. A sample of the patch work can be seen on Bay #9 in the upper left quadrant of the picture. This view was taken with an Electronic Still Camera (ESC).

Protection of yearling ponies against Strongylus vulgaris by foalhood vaccination.

PubMed

Klei, T R; French, D D; Chapman, M R; McClure, J R; Dennis, V A; Taylor, H W; Hutchinson, G W

1989-06-01

The long-term efficacy of an irradiation attenuated larval (L3) vaccine against Strongylus vulgaris was tested in ponies which were reared on pasture. Prior to foaling, mares were divided into two groups. One group of mares and foals received regular (eight weekly) treatment with ivermectin and the second group remained untreated. Half the foals in each pasture group were vaccinated at eight to ten weeks of age. Foals were weaned at three to four months of age and maintained on separate pastures. At eight to ten months of age, ponies were placed in box stalls and half of each treatment group were challenged with S. vulgaris (5 x 1000 L3). Clinical signs and lesions typical of acute verminous arteritis were found at necropsy in the ivermectin treated non-vaccinated challenged yearlings. Ivermectin treated vaccinated challenged yearlings did not show these clinical signs, had markedly reduced to absent arterial lesions and showed an 89 per cent reduction in arterial larval burdens post mortem. Significant differences in clinical signs, arterial lesions or arterial larval burdens were not seen between vaccinated and non-vaccinated foals reared without benefit of ivermectin treatment.

Attempted reconstitution of a foal with primary severe combined immunodeficiency.

PubMed

Campbell, T M; Studdert, M J; Ellis, W M; Paton, C M

1983-07-01

A foal with primary severe combined immunodeficiency, diagnosed within the first two weeks of life, was maintained with its dam in semi-isolation. The foal received continuous prophylactic antibiotic therapy, plasma from a sibling hyperimmunised with equine adenovirus vaccine, and intensive general nursing care. A full sibling female was selected as a bone marrow donor on the basis of red blood cell cross-matching and mixed lymphocyte reactions. Cyclophosphamide was given before two bone marrow transfusions at 35 and 73 days of age. To prevent graft versus host disease graft versus host disease the foal was maintained on methotrexate therapy. Reconstitution was not achieved nor were there signs of graft versus host disease. The foal died suddenly four days after the second bone marrow transfer when 77 days old. It had remained clinically free of any life threatening infectious disease and at necropsy a remarkable degree of freedom from infectious disease was confirmed. The most notable necropsy findings were bilateral nephrosis and myocardial degeneration and fibrosis. The likely cause of death was an electrolyte imbalance, particularly hypokalaemia, which secondarily affected the myocardium. Renal toxicity caused by the cytotoxic drugs, especially cyclophosphamide, may have contributed to the electrolyte imbalance.

Ultrasonography of umbilical structures in clinically normal foals.

PubMed

Reef, V B; Collatos, C

1988-12-01

The umbilical arteries, urachus, and umbilical vein were scanned ultrasonographically in 13 clinically normal foals that ranged in age from 6 hours to 4 weeks. Sonograms were obtained using a 7.5-MHz sector scanner transducer placed across the midline of the ventral portion of the foal's abdominal wall. The umbilical vein was scanned from the umbilical stalk to its entrance into the hepatic parenchyma. The mean (+/- SD) diameter of the umbilical vein was 0.61 +/- 0.20 cm immediately cranial to the umbilical stalk, 0.52 +/- 0.19 cm midway between the umbilicus and liver, and 0.6 +/- 0.19 cm at the liver. The urachus and umbilical arteries were scanned from the umbilical stalk to the apex of the urinary bladder and had a mean total diameter of 1.75 +/- 0.37 cm at the bladder apex. The umbilical arteries also were scanned along either side of the bladder and had a mean diameter of 0.85 +/- 0.21 cm. These measurements and the ultrasonographic appearance of the internal umbilical structures from clinically normal foals can be used as references to diagnose abnormalities of the umbilical structures in neonatal foals.

Intensive care of the neonatal foal.

PubMed

Koterba, A M; Drummond, W H; Kosch, P

1985-04-01

The basic concepts of diagnosis and treatment in the abnormal neonatal foal are presented. Methods of restraint, sedation, and general nursing care are discussed, as well as more specific techniques of respiratory and circulatory system support.

Multiple Exposure of Rendezvous Docking Simulator - Gemini Program

NASA Image and Video Library

1964-02-07

Multiple exposure of Rendezvous Docking Simulator. Francis B. Smith, described the simulator as follows: The rendezvous and docking operation of the Gemini spacecraft with the Agena and of the Apollo Command Module with the Lunar Excursion Module have been the subject of simulator studies for several years. This figure illustrates the Gemini-Agena rendezvous docking simulator at Langley. The Gemini spacecraft was supported in a gimbal system by an overhead crane and gantry arrangement which provided 6 degrees of freedom - roll, pitch, yaw, and translation in any direction - all controllable by the astronaut in the spacecraft. Here again the controls fed into a computer which in turn provided an input to the servos driving the spacecraft so that it responded to control motions in a manner which accurately simulated the Gemini spacecraft. -- Published in Barton C. Hacker and James M. Grimwood, On the Shoulders of Titans: A History of Project Gemini, NASA SP-4203 Francis B. Smith, Simulators for Manned Space Research, Paper presented at the 1966 IEEE International convention, March 21-25, 1966.

Development of Strongylus vulgaris-specific serum antibodies in naturally infected foals.

PubMed

Nielsen, M K; Vidyashankar, A N; Gravatte, H S; Bellaw, J; Lyons, E T; Andersen, U V

2014-03-01

Strongylus vulgaris is regarded as the most pathogenic helminth parasite infecting horses. Migrating larvae cause pronounced endarteritis and thrombosis in the cranial mesenteric artery and adjacent branches, and thromboembolism can lead to ischemia and infarction of large intestinal segments. A recently developed serum ELISA allows detection of S. vulgaris-specific antibodies during the six-month-long prepatent period. A population of horses has been maintained at the University of Kentucky without anthelmintic intervention since 1979, and S. vulgaris has been documented to be highly prevalent. In 2012, 12 foals were born in this population, and were studied during a 12-month period (March-March). Weekly serum samples were collected to monitor S. vulgaris specific antibodies with the ELISA. Nine colts underwent necropsy at different time points between 90 and 300 days of age. At necropsy, Strongylus spp. and Parascaris equorum were identified to species and stage and enumerated. Initial statistical findings indicate a significant interaction between foal age and ELISA results (p<0.042). All foals had initial evidence of S. vulgaris-directed maternal antibodies transferred in the colostrum, but then remained ELISA negative during their first three months of life. Foals born in February and March became ELISA positive at about 12 weeks of age, while those born in April and May went positive at about 15 and 21 weeks, respectively. Foal date of birth was significantly associated with ELISA results (p<0.0001). This could be explained by birth date-dependent differences in parasite exposure. One foal remained ELISA-negative throughout the course of 30 weeks during the study. A significant association was found between ELISA values and larval S. vulgaris burdens (p<0.0001) as well as a three-way interaction between S. vulgaris, S. edentatus, and P. equorum burdens (p<0.001). A plateau with a subsequent decline in ELISA values corresponded with S. vulgaris larvae leaving the bloodstream and migrating back to the intestine. Copyright © 2013 Elsevier B.V. All rights reserved.

The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia.

PubMed

Armstrong, S K; Woodgate, R G; Gough, S; Heller, J; Sangster, N C; Hughes, K J

2014-10-15

This study was performed to estimate the prevalence of patent Parascaris equorum infections and determine the efficacy of ivermectin, pyrantel and fenbendazole against P. equorum infection in foals on farms in southern Australia. Foals aged >3 months on five farms in the south-western slopes region of New South Wales were used. Faeces were collected from each foal and foals with a P. equorum faecal egg count (FEC) of >100 eggs per gram (EPG) were used to measure anthelmintic efficacy using the FEC reduction (FECR) test, after random allocation to a control group or an ivermectin, pyrantel embonate or fenbendazole treatment group. Treatment was administered on day 0 and faeces were collected on day 14 and a FEC was performed. For determination of anthelmintic efficacy, FECRs and lower 95% confidence intervals (LCL) were calculated using previously described methods, based on individual or group FECRs. P. equorum populations were considered susceptible when FECR was >90% and LCL >90%, suspected resistant when FECR was FECR was 80-90% and LCL <90% and resistant when FECR was <80% and LCL <90%. A Poisson distribution quality control method was applied to the data to remove suspected erroneous FECR results. Prevalence of patent P. equorum infection was 58.3% (147/252 foals) and 89 foals on 5 farms were included in the FECR study. Resistance of P. equorum to ≥ 1 anthelmintic was present on all five farms prior to and on four farms after application of the quality control method. Two farms had evidence of multiple drug resistance. Ivermectin was effective and ineffective on two and three farms, respectively. Fenbendazole was effective on two farms, equivocal on one farm and ineffective on one farm. Pyrantel embonate was effective on three farms and ineffective on one farm. These data indicate that anthelmintic-resistant P. equorum populations are present on farms in Australia and multiple drug resistance may occur on individual farms. Copyright © 2014 Elsevier B.V. All rights reserved.

STS-103 crew practice emergency egress in the slidewire basket

NASA Technical Reports Server (NTRS)

1999-01-01

In the slidewire basket on Launch Pad 39B, STS-103 Mission Specialist Steven L. Smith reaches for the lever that will release the basket. With Smith is fellow crew member Mission Specialist Jean-Frangois Clervoy of France. The baskets are part of the emergency egress system for persons in the Shuttle vehicle or on the Rotating Service Structure. Seven slidewires extend from the orbiter access arm, with a netted, flatbottom basket suspended from each wire. The STS-103 crew are taking part in Terminal Countdown Demonstration Test (TCDT) activities in preparation for launch. The other crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland. Clervoy and Nicollier are with the European Space Agency. The TCDT provides the crew with the emergency egress training, opportunities to inspect their mission payloads in the orbiter's payload bay, and simulated countdown exercises. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

Effectiveness of ivermectin against later 4th-stage Strongylus vulgaris in ponies.

PubMed

Slocombe, J O; McCraw, B M; Pennock, P W; Vasey, J

1982-09-01

Twelve pony foals were reared worm-free and inoculated with Strongylus vulgaris. Approximately 8 weeks after they were inoculated, 6 foals were given ivermectin IM at a dosage rate of 200 micrograms/kg of body weight and 6 were given a placebo. All foals were necropsied 35 days after treatment. Ivermectin was 98.9% effective in eliminating later 4th-stage S vulgaris larvae located near the origin of major intestinal arteries and in reducing clinical signs and permitting resolution of lesions associated with verminous arteritis. One pony foal reared on pasture and with evidence of arteritis of the cranial mesenteric and ileocolic arteries on arteriography was treated with ivermectin at a dosage rate of 200 micrograms/kg of body weight. On arteriographs taken subsequently, there was evidence of regression of the lesion, and at necropsy 9 weeks after treatment, there was no arteritis or larvae in those arteries.

Combined Effects of Spaceflight and Age in Astronauts as Assessed by Areal Bone Mineral Density [BMD] and Trabecular Bone Score

NASA Technical Reports Server (NTRS)

Sibonga, Jean D.; Spector, Elizabeth R.; Ploutz-Snyder, R.; Evans, H. J.; King, L.; Watts, N. B.; Hans, D.; Smith, S. A.

2013-01-01

Spaceflight is a potential risk factor for secondary osteoporosis in astronauts. Although lumbar spine (LS) BMD declines rapidly, more than expected for age, there have been no fragility fractures in astronauts that can clearly be attributed to spaceflight. Recently, astronauts have been returning from 6-month spaceflights with absolute BMD still above young adult mean BMD. In spite of these BMD measurements, we project that the rapid loss in bone mass over long-duration spaceflight affects the bone microarchitecture of the LS which might predispose astronauts to premature vertebral fractures. Thus, we evaluated TBS, a novel texture index correlated with vertebral bone microarchitecture, as a means of monitoring changes to bone microarchitecture in astronauts as they age. We previously reported that TBS detects an effect of spaceflight (6-month duration), independent of BMD, in 51 astronauts (47+/-4 y) (Smith et al, J Clin Densitometry 2014). Hence, TBS was evaluated in serial DXA scans (Hologic Discovery W) conducted triennially in all active and retired astronauts and more frequently (before spaceflight, after spaceflight and until recovery) in the subset of astronauts flying 4-6- month missions. We used non-linear models to describe trends in observations (BMD or TBS) plotted as a function of astronaut age. We fitted 1175 observations of 311 astronauts, pre-flight and then postflight starting 3 years after landing or after astronaut's BMD for LS was restored to within 2% of preflight BMD. Observations were then grouped and defined as follows: 1) LD: after exposure to at least one long-duration spaceflight > 100 days and 2) SD: before LD and after exposure to at least one short-duration spaceflight < 30 days. Data from males and females were analyzed separately. Models of SD observations revealed that TBS and BMD had similar curvilinear declines with age for both male and female astronauts. However, models of LD observations showed TBS declining with age while BMD appeared stable or trending upward. For females (n=8) LD observations were too few to discern a trend. Notably, models describing trends in TBS appeared to be more sensitive to the effects of age than the models for BMD. We conclude that TBS may provide an additional index for the lumbar spine to monitor the combined changes due to spaceflight and due to aging. This increased knowledge may enhance the ability to identify an intervention trigger for premature vertebral fractures in astronauts.

Potential role of maternal lineage in the thoroughbred breeding strategy.

PubMed

Lin, Xiang; Zhou, Shi; Wen, Li; Davie, Allan; Yao, Xinkui; Liu, Wujun; Zhang, Yong

2015-05-05

Many studies have focused on identifying the genes or single nucleotide polymorphisms associated with the athletic ability of thoroughbreds, but few have considered differences in maternal and paternal heritability of athletic ability. Herein, we report on our association study of career race performances of 675 Australian thoroughbreds with their pedigrees. Racing performance data (prize money per start) were collected from the Bloodhound database. The performance of all horses was categorised as either poor or elite athletic achievement. Then, 675 foals were divided by their parents' performance (elite or poor) into four groups: (1) elite dams and elite sires; (2) elite dams and poor sires; (3) poor dams and elite sires; and (4) poor dams and poor sires. The performance of foals was then compared between the four groups. The results show that the heritability of race performance between dams and foals (r = 0.141, P < 0.001) is much higher than that between sires and foals (r = 0.035, P = 0.366), and that this difference is statistically significant (P < 0.05). We also examined the effect of the child-bearing age of dams and sires on the ratio of elite foals. We found a strong correlation between the number of elite foals and dams' child-bearing age (r = -0.105, P < 0.001), with the ratio of elite offspring reaching a high level between a child-bearing age of 8 and 11 years (χ2 = 14.31, d.f. = 1, P < 0.001). These findings suggest that the maternal line may play an important role in the selective breeding of athletic performance in thoroughbreds.

Beta 2 toxigenic Clostridium perfringens type A colitis in a three-day-old foal.

PubMed

Hazlett, Murray J; Kircanski, Jasmina; Slavic, Durda; Prescott, John F

2011-03-01

Beta 2 (β2)-toxigenic Clostridium perfringens type A was recovered in large numbers from the intestine of a neonatal foal with colitis. The foal had been treated with gentamicin. Necropsy revealed marked distension of cecum and colon with watery, rust-colored homogeneous fluid and gastric infarction. Microscopic colonic lesions were superficial necrosis of 50% of the colonic mucosal surface and scattered 1-3-mm ulcers with subjacent neutrophilic infiltration and large Gram-positive bacilli in the necrotic mucosa. Beta-2 toxin was demonstrated in the lesions by immunohistochemical staining.

Early changes in the distal intertarsal joint of Dutch Warmblood foals and the influence of exercise on bone density in the third tarsal bone.

PubMed

Barneveld, A; van Weeren, P R

1999-11-01

It was hypothesised that imposition of different exercise levels at a young age would lead to differences in bone density in the third tarsal bone and to difference in the prevalence of pathological lesions that might contribute to the development of bone spavin later in life. Furthermore, based on earlier literature, it was hypothesised that such lesions could be classified as a manifestation of osteochondrosis. Changes in bone density in the third tarsal bone and early pathological changes in the articular cartilage of the distal intertarsal joint were studied in the offspring of sires with radiographic evidence of osteochondrosis in either stifle or hock. Twenty-four foals were studied at age 5 months after having been subjected to different exercise programmes (box-rest, box-rest with sprint training, pasture exercise) from age one week. Nineteen other foals that originally belonged to the same exercise groups were studied at age 11 months, after they had been weaned, housed together and subjected to an identical low level exercise regimen for an additional 6 months. Bone density was quantified using a microscopic technique. Histomorphological analysis was performed semiquantitatively and using high detail radiography techniques. At age 5 months, mean +/- s.d. bone density in the compact bone of the third tarsal bone was significantly lower in the box-rested foals (37 +/- 4%) than in both the trained and pastured foals (48 +/- 7% and 52 +/- 11%, respectively). After 6 months of identical exercise the previously box-rested foals showed an increase in bone density (53 +/- 12%) which became similar to the value found in the formerly pastured foals (52 +/- 8%). Major pathological lesions (chondrocyte necrosis, fragmentation and chondrone formation) of the articular cartilage of the third and central tarsal bones were already present at age 5 months, but were significantly more numerous at 11 months. There was no relation between the number of cartilage lesions and the osteochondrosis status of the foals. Only 2 lesions in 11-month-old foals had histological characteristics compatible with osteochondrosis, all other lesions were degenerative in nature. It is concluded that bone density of the compact bone of the subchondral bone plate in the third tarsal bone reacts strongly to variations in exercise at a very young age. Low bone density, caused by lack of exercise, can be compensated for when exercise is later increased. Pathological changes in the distal intertarsal joint are common at 5 months and increase to 11 months. These lesions are degenerative in nature and seem not to be related to osteochondrosis. Although the clinical relevance of these abnormalities is uncertain, they may be relevant for the development of osteoarthritic processes in this region later in life.

KSC-97PC1353

NASA Image and Video Library

1997-09-09

STS-86 crew members get a ride in, and learn to operate, an M-113 armored personnel carrier as part of training exercises during the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. George Hoggard, in back at left, a training officer with KSC Fire Services, provides this part of the training to Mission Specialists David A. Wolf, to the right of Hoggard; Jean-Loup J.M. Chretien of the French Space Agency; and Vladimir Georgievich Titov, in foreground, of the Russian Space Agency. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25 from Launch Pad 39A

KSC-97pc674

NASA Image and Video Library

1997-04-19

KENNEDY SPACE CENTER, FLA. -- McDonnell Douglas-SPACEHAB technicians look over a Russian-made oxygen generator which has just been placed on the floor of a SPACEHAB Double Module being prepared for flight on Space Shuttle Mission STS-84. The module is being processed in the SPACEHAB Payload Processing Facility just outside of Gate 1 on Cape Canaveral Air Station. The Space Shuttle Atlantis will transport the oxygen generator to the Russian Space Station Mir to replace one of two Mir units that have been malfunctioning recently. The nearly 300-pound generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet long with a diameter of 1.4 feet. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 launch. It will be the sixth Shuttle-Mir docking

KSC-97pc676

NASA Image and Video Library

1997-04-19

KENNEDY SPACE CENTER, FLA. -- McDonnell Douglas-SPACEHAB technicians prepare to place a Russian-made oxygen generator into position for transport in a SPACEHAB Double Module being processed for flight on Space Shuttle Mission STS-84. The module is undergoing preflight preparations in the SPACEHAB Payload Processing Facility just outside of Gate 1 on Cape Canaveral Air Station. The Space Shuttle Atlantis will carry the oxygen generator to the Russian Space Station Mir to replace one of two Mir units that have been malfunctioning recently. The nearly 300-pound generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet long with a diameter of 1.4 feet. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 launch. It will be the sixth Shuttle-Mir docking

KSC-97pc654

NASA Image and Video Library

1997-04-16

Representatives of RSC Energia in Russia and other onlookers in the SPACEHAB Payload Processing Facility examine an oxygen generator which the Space Shuttle Atlantis will carry to the Russian Mir Space Station on Mission STS-84. Sergei Romanov, second from right in the white shirt, is the spokesperson for generator manufacturer RSC Energia. The nearly 300-pound generator will be strapped down on the inside surface of a SPACEHAB Double Module for the trip to Mir. It will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking

KSC-97pc675

NASA Image and Video Library

1997-04-19

KENNEDY SPACE CENTER, FLA. -- McDonnell Douglas-SPACEHAB technicians strap in place a Russian-made oxygen generator on the floor of a SPACEHAB Double Module, being prepared for flight in the SPACEHAB Payload Processing Facility. From left, are Mark Halavin and Marc Tuttle. The oxygen generator, manufactured in Russia by RSC Energia, will be carried aboard the Space Shuttle Atlantis on Mission STS-84 for the Shuttle’s scheduled docking with the Russian Space Station Mir next month. The nearly 300-pound generator will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking

STS-86 crew members Lawrence, Titov and Parazynski in M-113

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 crew members get a ride in, and learn to operate, an M-113 armored personnel carrier as part of training exercises during the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. George Hoggard, in back at left, a training officer with KSC Fire Services, provides this part of the training to Mission Specialists David A. Wolf, to the right of Hoggard; Jean-Loup J.M. Chretien of the French Space Agency; and Vladimir Georgievich Titov, in foreground, of the Russian Space Agency. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25 from Launch Pad 39A.

STS-84 oxygen generator for Mir installation

NASA Technical Reports Server (NTRS)

1997-01-01

McDonnell Douglas-SPACEHAB technicians strap in place a Russian- made oxygen generator on the floor of a SPACEHAB Double Module, being prepared for flight in the SPACEHAB Payload Processing Facility. From left, are Mark Halavin and Marc Tuttle. The oxygen generator, manufactured in Russia by RSC Energia, will be carried aboard the Space Shuttle Atlantis on Mission STS-84 for the Shuttles scheduled docking with the Russian Space Station Mir next month. The nearly 300-pound generator will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking.

STS-84 oxygen generator for Mir installation

NASA Technical Reports Server (NTRS)

1997-01-01

McDonnell Douglas-SPACEHAB technicians oversee the move of a Russian-made oxygen generator to a SPACEHAB Double Module, at rear, in the SPACEHAB Payload Processing Facility. With faces visible in center foreground, from left, are Mark Halavin and Marc Tuttle; Mike Vawter is at far right. The oxygen generator, manufactured in Russia by RSC Energia, will be carried aboard the Space Shuttle Atlantis on Mission STS-84 for the Shuttles scheduled docking with the Russian Space Station Mir next month. The nearly 300-pound generator will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking.

STS-84 oxygen generator for Mir on display at SPACEHAB

NASA Technical Reports Server (NTRS)

1997-01-01

Representatives of RSC Energia in Russia and other onlookers in the SPACEHAB Payload Processing Facility examine an oxygen generator which the Space Shuttle Atlantis will carry to the Russian Mir Space Station on Mission STS-84. Sergei Romanov, second from right in the white shirt, is the spokesperson for generator manufacturer RSC Energia. The nearly 300-pound generator will be strapped down on the inside surface of a SPACEHAB Double Module for the trip to Mir. It will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking.

Recurrent convulsions in a thoroughbred foal: management and treatment.

PubMed

May, C J; Greenwood, R E

1977-07-23

A thoroughbred foal had a convulsive attack 12 hours after birth followed by further convulsions on the 10th, 11th and 12th days after birth. It was treated successfully by medication with primidone, feeding by stomach tube and careful nursing.

Plasma thromboxane B2 levels in horses experimentally infected with Strongylus vulgaris.

PubMed

Cambridge, H; Reynoldson, J A; Dunsmore, J D

1989-06-01

Plasma thromboxane B2 (TXB2) the stable inactive metabolite of thromboxane A2 (TXA2), was measured daily by specific radioimmunoassay in three groups of animals before and after experimental infection with Strongylus vulgaris. Infection of four 'parasite naive' foals produced a typical acute syndrome with intermittent but statistically insignificant rises in TXB2 levels. Interpretation of results was complicated by the presence of a non-septic peritonitis associated with implantation of the foals with electrodes for recording myoelectrical activity. In two foals of similar age, with some natural exposure to S. vulgaris, there was little or no clinical response to infection and increases in TXB2 were absent. Baseline levels were also much lower, indicating that the peritonitis may have affected the results obtained in the first group of foals. Severe mesenteric arteritis was confirmed at necropsy in all six foals. A third group of yearling horses, all with natural exposure to the parasite, were generally resistant to infection. One animal developed arteritis with clinical signs of diarrhoea and mild colic, and also showed intermittent increases in TXB2. The mean plasma TXB2 level after infection was significantly higher than in the control period, although absolute levels were lower than those recorded in the 'parasite naive' foals. Other animals in this group had low TXB2 levels and minimal arteritis was found at necropsy. These results indicate that although infection appears to have an effect on plasma TXB2, the changes are inconsistent and not reliable indicators of the presence of verminous arteritis. The results also confirm the difficulty in establishing infection and the variability of the response in animals with previous exposure.

Foaling rates in feral horses treated with the immunocontraceptive porcine zona pellucida

USGS Publications Warehouse

Ransom, J.I.; Roelle, J.E.; Cade, B.S.; Coates-Markle, L.; Kane, A.J.

2011-01-01

Locally abundant feral horses (Equus caballus) can rapidly deplete available resources. Fertility control agents present promising nonlethal tools for reducing their population growth rates. We tested the effect of 2 forms of the immunocontraceptive porcine zona pellucida (PZP) on foaling rates in 3 populations of feral horses in the western United States. A liquid form requiring annual boosters was administered at Little Book Cliffs Wild Horse Range, Mesa County (CO), and Pryor Mountain Wild Horse Range, Bighorn County (WY) and Carbon County (MT), and a time-release pellet form designed to produce 2 yr of infertility was administered at McCullough Peaks Herd Management Area, Park County (WY). Average foaling rates (foals born/mare-yr) from direct observation of untreated and treated female horses (mares), 2004-2008, were 60.1% (n = 153 mare-yr) versus 6.6% (n = 91 mare-yr) at Little Book Cliffs, and 62.8% (n = 129 mare-yr) versus 17.7% (n = 79 mare-yr) at Pryor Mountain, respectively. At McCullough Peaks, mean annual foaling rates from 2006 to 2008 were 75.0% (n = 48 mare-yr) for untreated mares and 31.7% (n = 101 mare-yr) for treated mares. Controlling for age of mares and pretreatment differences in fertility, PZP reduced foaling rates in all 3 herds. The pellets used at McCullough Peaks (produced by cold evaporation) were less effective than pellets used in a previous trial and produced by heat extrusion. Immunocontraception with PZP may be a useful tool in reducing fertility rates in some western United States feral horse herds, but population growth reduction will depend on timely access to mares for inoculation and the proportion of mares that can be successfully treated. ?? 2011 The Wildlife Society.

Influence of type of muscles on nutritional value of foal meat.

PubMed

Lorenzo, José M; Pateiro, Mirian

2013-03-01

The effect of type of muscle on nutritional characteristic (fatty acid profile, amino acid content, cholesterol and major and minor mineral) of foal meat was investigated. Six muscles: longissimus dorsi (LD), semimembranosus (SM), semitendinosus (ST), biceps femoris (BF), triceps brachii (TB) and psoas major & minor (PM) from twelve foals slaughtered at 15 months from an extensive production system in freedom regimen were extracted for this study. Horse meat is characterized by low fat, low cholesterol content, rich in iron and in vitamin B. Statistical analysis showed that the cholesterol content did not show significant differences (P>0.05) among muscle with mean value range between 0.62 and 0.57 mg/100g. Most fatty acid presented significant differences (P<0.05) with respect to the type of muscle. The obtained results showed that except for the polyunsaturated linoleic acid, the highest contents of fatty acids were found in the hindquarter muscles. Regarding amino acid profile, significant differences (P<0.05) were observed among muscles and our results indicated that, 100g of foal meat covered from 80.6 to 86.7% for the daily requirement for an adult man weighing 70 kg for essential amino acids for ST and LD muscles, respectively. Statistical analysis showed significant differences (P=0.050) for the EAA (essential amino acids) index, which was highest for TB muscle, followed by BF and SM muscles, while the lowest values were reported by ST muscle. Finally, foal meat seems to be a very good nutritional source of major and minor minerals. The higher nutritional value of foal meat will be of great importance in the promotion of this meat. Copyright © 2012 Elsevier Ltd. All rights reserved.

Accuracy of a Mouse Bioassay for the Diagnosis of Botulism in Horses.

PubMed

Johnson, A L; McAdams-Gallagher, S C; Aceto, H

2016-07-01

The laboratory diagnosis of botulism in horses traditionally has relied upon the mouse bioassay (MBA). The accuracy of this test for the diagnosis of botulism in horses is unknown. Our goal was to determine the sensitivity, specificity, positive predictive value, and negative predictive value of the MBA on laboratory-processed fecal and gastrointestinal samples for foals and adult horses. Cases included all horses with a final clinical diagnosis of botulism that were admitted between 1986 and 2011 and had MBA testing performed. Controls included horses without botulism that were admitted during the same time period and had MBA testing performed. Retrospective study. Horses suspected of having botulism had fecal or (less commonly) gastrointestinal content samples tested using MBA. For every hospitalized botulism suspect, control samples were obtained from ≥1 additional hospitalized horses not suspected to have botulism. One hundred and twenty-nine adult horses and 253 adult controls were identified. Overall sensitivity of the MBA was only 32% but specificity was 97%. Forty-three foal cases and 21 foal controls were evaluated; sensitivity of the MBA was 53% and specificity was 100%. Positive predictive value was substantially higher (100% for foals and 89% for adults) than negative predictive value (51% for foals and 67% for adults). Mouse bioassay has low sensitivity but high specificity for the diagnosis of botulism in horses. Positive results are highly suggestive of botulism but negative results do not exclude the diagnosis. Unaffected horses and foals rarely shed C. botulinum in their feces. Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

[Technique of abdominal ultrasonography in newborn foals and normal findings].

PubMed

Behn, C; Bostedt, H

2000-09-01

Under field conditions, the diagnosis of foal's diseases relies almost exclusively on the physical examination. As the signs of illness in the equine neonate are frequently vage and non-localizing, the diagnosis of diseases may be problematic. This often causes misinterpretations and leads to ineffective prophylaxis and treatment. The purpose of this study was to evaluate the usefulness of diagnostic ultrasonography of the foal's abdomen under field conditions to provide an optimized technique and to describe the normal findings. Diagnostic ultrasonography of the abdomen was performed after obtaining clinical history and passing the physical examination of 25 foals without signs of abdominal problems. The foals were scanned in a stable box, being restrained by three persons in semi-lateral recumbency. Usually, sedation was not necessary. The ventral abdominal wall was clipped, a generous amount of ultrasound coupling gel was applied and massaged on the skin surface. The ultrasonographic examination was carried out using a portable sector scanner ("Microimager 2000", Ausonics) with 5.0 and 7.5-MHz transducers or a combined 5.0 and 7.5-MHz transrectal linear-array scanner ("450 Enhanced", Pie Medical). Employing the 5.0-MHz sector scanner first, the abdomen was explored from caudal to cranial in left and right semi-lateral recumbency. The 7.5-MHz scanner was used to attain higher resolution of certain structures. The sector scanner turned out to be suitable under field conditions and adequate to examine the abdominal organs. The transrectal linear-array scanner also provided the most important informations, although it was difficult to maintain a good contact area of the scan head. By ultrasonography it was possible to identify the urinary bladder, kidneys, spleen, liver and part of the gastrointestinal tract. Thus, application of ultrasound could successfully be performed on newborn foals under field conditions.

Age-related changes in select fecal bacteria in foals

USDA-ARS?s Scientific Manuscript database

Adult horses depend on the microbial community in the hindgut to produce VFAs that are utilized for energy. Microbial colonization in the gastrointestinal tract of foals is essential to develop a healthy symbiotic relationship and prevent proliferation of pathogenic bacteria. However, colonization i...

Salter-Harris type II metacarpal and metatarsal fracture in three foals. Treatment by minimally-invasive lag screw osteosynthesis combined with external coaptation.

PubMed

Klopfenstein Bregger, Micaël D; Fürst, Anton E; Kircher, Patrick R; Kluge, Katharina; Kummer, Martin

2016-05-18

To describe minimally-invasive lag screw osteosynthesis combined with external coaptation for the treatment of Salter-Harris type II third metacarpal and third metatarsal bone fractures. Three foals aged two weeks to four months with a Salter-Harris type II third metacarpal or third metatarsal fracture. Surgery was carried out under general anaesthesia in lateral recumbency. After fracture reduction, the metaphyseal fragment was stabilized with two cortical screws placed in lag fashion under fluoroscopic control. A cast was applied for at least two weeks. All foals had a good outcome with complete fracture healing and return to complete soundness without any angular limb deformity. All foals had moderate transient digital hyperextension after cast removal. Internal fixation of Salter-Harris type II third metacarpal or third metatarsal fractures with two cortical screws in lag fashion, combined with external coaptation provided good stabilization and preserved the longitudinal growth potential of the injured physis.

Tyzzer's disease in foals: retrospective studies from 1969 to 2010.

PubMed

Swerczek, Thomas W

2013-09-01

Reports of 148 cases of Tyzzer's disease in foals in central Kentucky were analyzed to identify features of the disease and factors associated with it. The records indicate that Tyzzer's disease is a rapidly progressive, highly fatal hepatitis caused by Clostridium piliforme. Common clinical findings are lethargy, fever, anorexia, and icterus. Seizures, coma, and death may rapidly ensue. Laboratory findings are leukopenia, metabolic acidosis, hypoglycemia, and increased activity of hepatic enzymes. Diagnosis is primarily based on clinical signs and postmortem findings but a polymerase chain reaction (PCR) is now available to detect C. piliforme DNA in organs and feces. Disease occurred most frequently in foals between 9 and 30 days of age that were born in April to May and was associated with heavy rainfall in the spring and high protein and nitrogenous diets fed to nursing mares. The findings are consistent with the ingestion of C. piliforme in the feces of adult horses and overgrowth in the intestine of foals with a high level of nutrients in their intestine.

Colour Changes in Meat of Foals as Affected by Slaughtering Age and Post-thawing Time

PubMed Central

De Palo, P.; Maggiolino, A.; Centoducati, P.; Tateo, A.

2012-01-01

The aim of the present work was to investigate how colour changes of foal meat can vary after thawing out in relation to the slaughtering age of the horses and to the post-thawing time. Eighteen Italian Heavy Draught Horse (IHDH) foals were used for the trial. They were subdivided in three groups according to their slaughtering age (6, 11 and 18 months). Two different surfaces were investigated for each sample: a fresh cut surface (daily renewed cutting surface: DRCS), and not-renewed cutting surface (NRCS). The redness of both investigated surfaces increased with slaughtering age (p<0.01). Moreover, this parameter decreased during post-thawing time (p<0.01) only on the NRCS, probably due to the myoglobin oxidation processes. Colour is an important visual cue denoting perceived quality by consumers. So, by a chromatic perspective the thawed meat of IHDH foals slaughtered at 6 and 11 months proved to be that which best meets the market requirements. PMID:25049544

Environmental zinc and cadmium pollution associated with generalized osteochondrosis, osteoporosis, and nephrocalcinosis in horses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gunson, D.E.; Kowalczyk, D.F.; Shoop, C.R.

1982-02-01

Several suspect causes of chronic zinc/cadmium toxicosis in horses near a zinc smelter were investigated following observations of lameness, swollen joints, and unthriftiness, particularly in foals. Two foals born and raised near the smelter were lame and had joint swellings that were attributable to severe generalized osteochondrosis. Zinc and cadmium concentrations were markedly increased in the pancreas, liver, and kidney. The serum of 1 foal, zinc and potassium concentrations were high, whereas calcium and magnesium concentrations were low. Marked nephrocalcinosis and osteoporosis were observed in this foal. Nephrocalcinosis also was observed in his dam, who died of a punctured lungmore » following rib fractures, though there was no history of trauma. The joint cartilage lesions were similar to those induced experimentally in animals fed high-zinc diets and may have been the result of zin-induced abnormality of copper metabolism. The osteoporosis and nephrocalcinosis were consistent with chronic cadmium toxicosis.« less

Survey of Veterinarians Using a Novel Physical Compression Squeeze Procedure in the Management of Neonatal Maladjustment Syndrome in Foals.

PubMed

Aleman, Monica; Weich, Kalie M; Madigan, John E

2017-09-05

Horses are a precocious species that must accomplish several milestones that are critical to survival in the immediate post-birth period for their survival. One essential milestone is the successful transition from the intrauterine unconsciousness to an extrauterine state of consciousness or awareness. This transition involves a complex withdrawal of consciousness inhibitors and an increase in neuroactivating factors that support awareness. This process involves neuroactive hormones as well as inputs related to factors such as cold, visual, olfactory, and auditory stimuli. One factor not previously considered in this birth transition is a yet unreported direct neural reflex response to labor-induced physical compression of the fetus in the birth canal (squeezing). Neonatal maladjustment syndrome (NMS) is a disorder of the newborn foal characterized by altered behavior, low affinity for the mare, poor awareness of the environment, failure to bond to the mother, abnormal sucking, and other neurologically-based abnormalities. This syndrome has been associated with altered events during birth, and was believed to be caused exclusively by hypoxia and ischemia. However, recent findings revealed an association of the NMS syndrome with the persistence of high concentrations of in utero neuromodulating hormones (neurosteroids) in the postnatal period. Anecdotal evidence demonstrated that a novel physical compression (squeeze) method that applies 20 min of sustained pressure to the thorax of some neonatal foals with this syndrome might rapidly hasten recovery. This survey provides information about outcomes and time frames to recovery comparing neonatal foals that were given this squeeze treatment to foals treated with routine medical therapy alone. Results revealed that the squeeze procedure, when applied for 20 min, resulted in a faster full recovery of some foals diagnosed with NMS. The adjunctive use of a non-invasive squeeze method may improve animal welfare by hastening recovery and foal-mare interactions that minimize health problems. This would also avoid or reduce costs arising from hospitalization associated with veterinary and nursing care that sometimes leads owners to elect for euthanasia.

Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age

PubMed Central

Nouveau, E.; Gautier, C.; Mendoza, L.; Dubois, C.; Dahirel, M.; Lagofun, B.; Aubrière, M-C; Lejeune, J-P; Caudron, I.; Guenon, I.; Viguié, C.; Wimel, L.; Bouraima-Lelong, H.; Serteyn, D.; Couturier-Tarrade, A.; Chavatte-Palmer, P.

2018-01-01

Introduction Obesity is a growing concern in horses. The effects of maternal obesity on maternal metabolism and low-grade inflammation during pregnancy, as well as offspring growth, metabolism, low-grade inflammation, testicular maturation and osteochondrotic lesions until 18 months of age were investigated. Material and methods Twenty-four mares were used and separated into two groups at insemination according to body condition score (BCS): Normal (N, n = 10, BCS ≤4) and Obese (O, n = 14, BCS ≥4.25). BCS and plasma glucose, insulin, triglyceride, urea, non-esterified fatty acid, serum amyloid A (SAA), leptin and adiponectin concentrations were monitored throughout gestation. At 300 days of gestation, a Frequently Sampled Intravenous Glucose Tolerance Test (FSIGT) was performed. After parturition, foals’ weight and size were monitored until 18 months of age with plasma SAA, leptin, adiponectin, triiodothyronine (T3), thyroxine (T4) and cortisol concentrations measured at regular intervals. At 6, 12 and 18 months of age, FSIGT and osteoarticular examinations were performed. Males were gelded at one year and expression of genes involved in testicular maturation analysed by RT-qPCR. Results Throughout the experiment, maternal BCS was higher in O versus N mares. During gestation, plasma urea and adiponectin were decreased and SAA and leptin increased in O versus N mares. O mares were also more insulin resistant than N mares with a higher glucose effectiveness. Postnatally, there was no difference in offspring growth between groups. Nevertheless, plasma SAA concentrations were increased in O versus N foals until 6 months, with O foals being consistently more insulin resistant with a higher glucose effectiveness. At 12 months of age, O foals were significantly more affected by osteochondrosis than N foals. All other parameters were not different between groups. Conclusion In conclusion, maternal obesity altered metabolism and increased low-grade inflammation in both dams and foals. The risk of developing osteochondrosis at 12 months of age was also higher in foals born to obese dams. PMID:29373573

Effects of Moderate Amounts of Barley in Late Pregnancy on Growth, Glucose Metabolism and Osteoarticular Status of Pre-Weaning Horses

PubMed Central

Peugnet, Pauline; Robles, Morgane; Mendoza, Luis; Wimel, Laurence; Dubois, Cédric; Dahirel, Michèle; Guillaume, Daniel; Camous, Sylvaine; Berthelot, Valérie; Toquet, Marie-Pierre; Richard, Eric; Sandersen, Charlotte; Chaffaux, Stéphane; Lejeune, Jean-Philippe; Tarrade, Anne; Serteyn, Didier; Chavatte-Palmer, Pascale

2015-01-01

In stud management, broodmares are commonly fed concentrates in late pregnancy. This practice, however, was shown to correlate with an increased incidence of osteochondrosis in foals, which may be related to insulin sensitivity. We hypothesized that supplementation of the mare with barley in the last trimester of pregnancy alters the pre-weaning foal growth, glucose metabolism and osteoarticular status. Here, pregnant multiparous saddlebred mares were fed forage only (group F, n=13) or both forage and cracked barley (group B, n=12) from the 7th month of pregnancy until term, as calculated to cover nutritional needs of broodmares. Diets were given in two daily meals. All mares and foals returned to pasture after parturition. Post-natal growth, glucose metabolism and osteoarticular status were investigated in pre-weaning foals. B mares maintained an optimal body condition score (>3.5), whereas that of F mares decreased and remained low (<2.5) up to 3 months of lactation, with a significantly lower bodyweight (-7%) than B mares throughout the last 2 months of pregnancy. B mares had increased plasma glucose and insulin after the first meal and after the second meal to a lesser extent, which was not observed in F mares. B mares also had increased insulin secretion during an intravenous glucose tolerance test (IVGTT). Plasma NEFA and leptin were only temporarily affected by diet in mares during pregnancy or in early lactation. Neonatal B foals had increased serum osteocalcin and slightly increased glucose increments and clearance after glucose injection, but these effects had vanished at weaning. Body measurements, plasma IGF-1, T4, T3, NEFA and leptin concentrations, insulin secretion during IVGTT, as well as glucose metabolism rate during euglycemic hyperinsulinemic clamps after weaning, did not differ between groups. Radiographic examination of joints indicated increased osteochondrosis relative risk in B foals, but this was not significant. These data demonstrate that B or F maternal nutrition has very few effects on foal growth, endocrinology and glucose homeostasis until weaning, but may induce cartilage lesions. PMID:25875166

The Equine Neonatal Cardiovascular System in Health and Disease.

PubMed

Marr, Celia M

2015-12-01

The neonatal foal is in a transitional state from prenatal to postnatal circulation. Healthy newborn foals often have cardiac murmurs and dysrhythmias, which are usually transient and of little clinical significance. The neonatal foal is prone to infection and cardiac trauma. Echocardiography is the main tool used for valuation of the cardiovascular system. With prompt identification and appropriate action, dysrhythmias and other sequel to cardiac trauma can be corrected. With infection, the management and prognosis are driven by concurrent sepsis. Congenital disease represents an interesting diagnostic challenge for the neonatologist, but surgical correction is not appropriate for most equids. Copyright © 2015 Elsevier Inc. All rights reserved.

Bilateral Carpus Valgus with Cranial Bowing of the Distal Radius in a Foal

PubMed Central

Caron, J. P.; Fretz, P. B.; Pharr, J. W.; Bailey, J. V.

1986-01-01

Bilateral carpus valgus with concomitant outward rotation and cranial bowing of the distal radii was diagnosed in a crossbred foal. The foal was not lame on admission and showed no radiographic evidence of carpal bone abnormalities. Surgery was limited to the most severely affected leg, and consisted of a combination of growth promotion (periosteal transection and stripping) and temporary physeal retardation (transphyseal bridging) procedures. Correction of the valgus deformity was nearly complete in the operated limb and substantial improvement was observed in the cranial bowing and outward rotation in both limbs, five months postoperatively. ImagesFigure 1.Figure 2. PMID:17422668

Mesenteric lymphangitis and sepsis due to RTX toxin-producing Actinobacillus spp in 2 foals with hypothyroidism-dysmaturity syndrome.

PubMed

Löhr, C V; Polster, U; Kuhnert, P; Karger, A; Rurangirwa, F R; Teifke, J P

2012-07-01

Actinobacillus suis-like organisms (ASLOs) have been isolated from the genital, respiratory, and digestive tracts of healthy adult horses, horses with respiratory disease, and septic foals. Two foals with congenital hypothyroidism-dysmaturity syndrome from separate farms developed ASLO infection. At necropsy, both had contracted carpal flexor tendons, thyroid hyperplasia, and thrombotic and necrotizing mesenteric lymphangitis and lymphadenitis; one foal also had mandibular prognathism. Numerous ASLOs were isolated from tissues from both foals, including intestine. Biochemical testing and mass spectrometric analysis of the two Actinobacillus isolates did not allow unequivocal identification. Comparative genetic analysis was done on these and similar isolates, including phylogeny based on 16S rRNA, rpoB and recN genes, as well as RTX (repeat in toxin) toxin typing of apxIA-apxIVA and aqxA genes. One isolate was identified as Actinobacillus suis sensu stricto, based on the presence of apxIA and apxIIA but not aqxA, whereas the other isolate had aqxA but neither apxIA nor apxIIA, consistent with A equuli ssp haemolyticus. Based on genotypic analysis of the isolates included for comparison, 3 of 3 equine ASLOs and 2 of 5 A equuli isolates were reclassified as A equuli subsp haemolyticus, emphasizing the importance of toxin genotyping in accurate classification of actinobacilli.

Correlation between serum total globulins and gamma globulins and their use to diagnose failure of passive transfer in foals.

PubMed

Fouché, Nathalie; Graubner, Claudia; Howard, Judith

2014-11-01

Various assays have been used as an aid to diagnose failure of passive transfer (FPT) of immunoglobulins in neonatal foals, but often lack sensitivity as screening tests, or are time consuming to perform and impractical as confirmatory tests. The aim of the present study was to evaluate whether measurement of serum total globulins (TG; i.e. total protein minus albumin) can be used to estimate the electrophoretic gamma globulin (EGG) fraction in hospitalised neonatal foals with suspected FPT. Sample data from 56 foals were evaluated retrospectively. The coefficient of rank correlation was 0.84. The area under the curve of ROC analysis was 0.887, 0.922 and 0.930 for EGG concentrations <2 g/L, < 4 g/L and <8 g/L, respectively. Cut-offs for TG achieved ≥90% sensitivity for detecting EGG <2 g/L, < 4 g/L and <8 g/L, with negative predictive values of >97% and >94%, using prevalence of 15% and 30%, respectively. These results suggest that measurement of TG can be used as a guide to predicting EGG, provided that appropriate cut-off values are selected, and this technique could be a useful initial screening test for FPT in foals. Copyright © 2014 Elsevier Ltd. All rights reserved.

Mass envenomation of a mare and foal by bees.

PubMed

Lewis, N; Racklyeft, D J

2014-05-01

The clinical course of toxic envenomation of a mare and her foal after an attack by a swarm of bees in the Upper Hunter Valley of New South Wales is described. Early agitation and urticaria were followed by more severe systemic clinical signs within 18 h. There was severe, generalised angioedema, rhabdomyolysis, hypovolaemia, gastrointestinal stasis and renal injury. A particular feature in the mare was almost maniacal behaviour during the first 48 h. Clinical pathological examination showed evidence of haemoconcentration, intravascular haemolysis, thrombocytopenia, azotaemia, rhabdomyolysis and hypoproteinaemia. Symptomatic treatment was initiated using intravenous fluids, anti-inflammatory drugs, histamine antagonists, analgesia and antibiotics. The foal responded within 12 h, but management of the mare was complicated by severe pain, generalised oedema, intrauterine haemorrhage, renal injury and later, recurrent fever. The most severe, acute effects of mass envenomation lasted for 3-4 days. Neither mare nor foal suffered any known lasting systemic effects of envenomation, although localised dermal necrosis resulted in white hairs at some sting sites and deformed ear tips in the foal. Early recognition of clinical signs and treatment of toxic envenomation with an understanding of the physiological effects of hymenoptera venom can lead to a favourable outcome in horses receiving a non-lethal dose. Further case reports of the treatment of affected horses are needed to expand knowledge of how best to approach this rare, but serious intoxication. © 2014 Australian Veterinary Association.

KSC-99pp1473

NASA Image and Video Library

1999-12-19

Space Shuttle Discovery hurtles through clouds of smoke and steam in its successful launch on mission STS-103. Liftoff occurred at 7:50 p.m. EST from Launch Pad 39B. On board are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. STS-103 is a Hubble Servicing Mission, with three planned space walks designed to install new equipment and replace old. The primary objective is to replace the gyroscopes that make up the three Rate Sensor Units. Extravehicular activities include installing a new computer, changing out one of the Fine Guidance Sensors, replacing a tape recorder with a new solid state recorder, and installing a voltage/temperature improvement kit, and begin repairing the insulation on the telescope's outer surface. After the 7-day, 21-hour mission, Discovery is targeted to land at KSC Monday, Dec. 27, at about 5:24 p.m. EST. This is the 27th flight of Discovery and the 96th mission in the Space Shuttle Program. It is the third launch at Kennedy Space Center in 1999

21 CFR 522.2063 - Pyrilamine.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS...) Horses, 40 to 60 mg per 100 pounds (lbs) body weight; foals, 20 mg/100 lbs body weight. Administer by... necessary. (ii) Horses, 40 to 60 mg/100 lbs body weight; foals, 20 mg/100 lbs body weight. Administer by...

Successful foaling by a Standardbred mare with a ruptured prepubic tendon.

PubMed

Schutten, Kerry J V

2016-12-01

A 12-year-old Standardbred mare was diagnosed with a ruptured prepubic tendon 1 month prepartum. The mare was treated with analgesia, stall rest, and an abdominal support wrap that was tightened daily. Both a live foal born 1 month later and the mare are doing well.

STS-51L CREW INSIGNIA

NASA Image and Video Library

1985-12-18

S85-46260 (20 Dec. 1985) --- Members of the STS-51L crew designed this patch which will represent their participation on NASA's late January 1986 mission aboard the space shuttle Challenger, depicted launching from Florida and soaring into space to carry out a variety of goals. Among the prescribed duties of the five astronauts and two payload specialists will be observation and photography of Halley's Comet, backdropped against the United States flag in the insignia. Surnames of the crew members encircle the scene, with the payload specialists being recognized below. Surname of the first teacher in space, Sharon Christa McAuliffe, is followed by a symbolic apple. Gregory Jarvis, representing Hughes, is the industrial payload specialist for the flight. NASA's crew members are astronauts Francis R. (Dick) Scobee, commander; Michael J. Smith, pilot; and Ronald E. McNair, Ellison S. Onizuka and Judith A. Resnik - all mission specialists. The NASA insignia design for space shuttle flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the forms of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, the change will be publicly announced. Photo credit: NASA

Gemini Rendezvous Docking Simulator

NASA Image and Video Library

1964-05-11

Gemini Rendezvous Docking Simulator suspended from the roof of the Langley Research Center s aircraft hangar. Francis B. Smith wrote: The rendezvous and docking operation of the Gemini spacecraft with the Agena and of the Apollo Command Module with the Lunar Excursion Module have been the subject of simulator studies for several years. This figure illustrates the Gemini-Agena rendezvous docking simulator at Langley. The Gemini spacecraft was supported in a gimbal system by an overhead crane and gantry arrangement which provided 6 degrees of freedom - roll, pitch, yaw, and translation in any direction - all controllable by the astronaut in the spacecraft. Here again the controls fed into a computer which in turn provided an input to the servos driving the spacecraft so that it responded to control motions in a manner which accurately simulated the Gemini spacecraft. -- Published in Barton C. Hacker and James M. Grimwood, On the Shoulders of Titans: A History of Project Gemini, NASA SP-4203 Francis B. Smith, Simulators for Manned Space Research, Paper presented at the 1966 IEEE International convention, March 21-25, 1966.

Gastric ulceration in an equine neonate

PubMed Central

Lewis, Susan

2003-01-01

A 24-hour-old colt presented with clinical signs consistent with gastric ulceration. Treatment was initiated with a histamine type-2 receptor antagonist and clinical signs resolved. Gastroscopy at 16 d confirmed the presence of a gastric ulcer. Although gastric ulceration is common in foals, it is rarely reported in foals this young. PMID:12757136

Respiratory problems in foals.

PubMed

Beech, J

1985-04-01

Despite major advances in our knowledge and ability to treat respiratory diseases in neonatal foals, neonatal respiratory medicine is still in its infancy. It is hoped that this article may serve as a guideline for diagnosis and treatment. Specific antibiotic regimens and emergency procedures are covered in other articles in this symposium. Because management factors play a critical role in the pathogenesis of respiratory disease, education of clients as to their importance would help both prophylactically and therapeutically. The necessity of very careful monitoring of neonates, which is critical to early detection of disease, should be stressed. As respiratory diseases can be fulminant and rapidly fatal, it is imperative not to delay diagnosis and therapy. Thorough examination and implementation of appropriate diagnostic techniques, as well as prompt early referral to a more sophisticated facility when indicated, would prevent many deaths. Although sophisticated support systems are vital for survival of some of these foals, good basic intensive nursing care combined with selection of appropriate drug therapy very early in the course of the disease is all that many foals require and can significantly improve survival rates.

Cloned foal derived from in vivo matured horse oocytes aspirated by the short disposable needle system.

PubMed

Lee, Wonyou; Song, Kilyoung; Lee, Inhyung; Shin, Hyungdo; Lee, Byeong Chun; Yeon, Seongchan; Jang, Goo

2015-01-01

Transvaginal ultrasound-guided follicle aspiration is one method of obtaining recipient oocytes for equine somatic cell nuclear transfer (SCNT). This study was conducted: (1) to evaluate the possibility of oocyte aspiration from pre-ovulatory follicles using a short disposable needle system (14-G) by comparing the oocyte recovery rate with that of a long double lumen needle (12-G); (2) to investigate the developmental competence of recovered oocytes after SCNT and embryo transfer. The recovery rates with the short disposable needle vs. the long needle were not significantly different (47.5% and 35.0%, respectively). Twenty-six SCNT embryos were transferred to 13 mares, and one mare delivered a live offspring at Day 342. There was a perfect identity match between the cloned foal and the cell donor after analysis of microsatellite DNA, and the mitochondrial DNA of the cloned foal was identical with that of the oocyte donor. These results demonstrated that the short disposable needle system can be used to recover oocytes to use as cytoplasts for SCNT, in the production of cloned foals and for other applications in equine embryology.

Antimicrobial-induced endotoxin and cytokine activity in an in vitro model of septicemia in foals.

PubMed

Bentley, Adrienne P; Barton, Michelle H; Lee, Margie D; Norton, Natalie A; Moore, James N

2002-05-01

To determine which antimicrobials that are used to treat neonatal foals with septicemia attributable to Escherichia coli will minimize endotoxin release from bacteria and subsequent activity of inflammatory mediators while maintaining bactericidal efficacy. Blood samples from 10 healthy foals. Escherichia coli isolates A and B were isolated from 2 septicemic foals, and minimal inhibitory concentrations (MIC) were determined for 9 antimicrobials. Five of these antimicrobials were tested in vitro at 2 and 20 times their respective MIC. Whole blood or mononuclear cells grown in tissue-culture media were incubated with 105 colony-forming units of E. coli and each antimicrobial or saline (0.9% NaCl) solution. After 6 hours, number of viable bacteria remaining was determined, and supernatant was tested for endotoxin and tumor necrosis activity. Testing in whole blood was compromised by bactericidal effects of the blood itself. In mononuclear cell suspensions, each antimicrobial significantly reduced the number of viable bacteria to low or undetectable amounts. Antimicrobials did not differ significantly in efficacy of bacterial killing. Amikacin used alone or in combination with ampicillin resulted in significantly less endotoxin activity than did ampicillin, imipenem, or ceftiofur alone. There was a correlation between TNF-alpha and endotoxin activity. Aminoglycosides appear less likely to induce endotoxemia and TNF-alpha synthesis during bactericidal treatment of E. coli septicemia, compared with beta-lactam antimicrobials. Use of ampicillin, imipenem, or ceftiofur in the treatment of septicemic neonatal foals should be accompanied by appropriate treatment for endotoxemia.

Effects of age and season on haematological parameters of donkeys during the rainy and cold-dry seasons

NASA Astrophysics Data System (ADS)

Zakari, Friday Ocheja; Ayo, Joseph Olusegun; Rekwot, Peter Ibrahim; Kawu, Mohammed Umar

2015-12-01

The aim of the study was to investigate the effects of age and season on haematological parameters of donkeys at rest during the rainy and cold-dry seasons. Thirty healthy donkeys divided into three groups based on their age served as the subjects. During each season, blood sample was collected from each donkey thrice, 2 weeks apart, for haematological analysis, and the dry-bulb temperature (DBT), relative humidity (RH) and temperature-humidity index (THI) were obtained thrice each day during the experimental period using standard procedures. During the rainy season, the mean DBT (33.05 ± 0.49 °C), RH (73.63 ± 1.09 %) and THI (84.39 ± 0.71) were higher ( P < 0.0001) than the corresponding values of 24.00 ± 0.44 °C, 36.80 ± 0.92 % and 64.80 ± 0.62, during the cold-dry season. Packed cell volume (PCV), erythrocyte count [red blood cell (RBC)], haemoglobin concentration (Hb), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), platelet count (PLT), leucocyte count [white blood cell (WBC)], lymphocyte count (LYM) and neutrophil/lymphocyte ratio (N/L) were higher ( P < 0.05) in adults than foals during the rainy season. The MCV, MCH, WBC, NEU, LYM and PLT of adult and yearling donkeys were higher ( P < 0.05) during the rainy than the cold-dry season. The PCV, RBC, Hb, MCV, MCH, and NEU of foals were higher in the rainy than the cold-dry season. The N/L of adult and foal donkeys were higher ( P < 0.05) in the rainy than in the cold-dry season. In conclusion, PCV, RBC, Hb and LYM were considerably higher in foals than yearlings or adults during the rainy season, while erythrocytic indices and platelet counts were higher in adults or yearlings than in foals in both seasons. Erythrocytic indices, PLT and N/L were higher in the rainy than the cold-dry season in adults, yearlings and foals.

Immunocontraception in Wild Horses (Equus caballus) Extends Reproductive Cycling Beyond the Normal Breeding Season

PubMed Central

Nuñez, Cassandra M. V.; Adelman, James S.; Rubenstein, Daniel I.

2010-01-01

Background Although the physiological effects of immunocontraceptive treatment with porcine zona pellucida (PZP) have been well studied, little is known about PZP's effects on the scheduling of reproductive cycling. Recent behavioral research has suggested that recipients of PZP extend the receptive breeding period into what is normally the non-breeding season. Methodology/Principal Findings To determine if this is the case, we compiled foaling data from wild horses (Equus caballus) living on Shackleford Banks, North Carolina for 4 years pre- and 8 years post-contraception management with PZP (pre-contraception, n = 65 births from 45 mares; post-contraception, n = 97 births from 46 mares). Gestation lasts approximately 11–12 months in wild horses, placing conception at approximately 11.5 months prior to birth. Since the contraception program began in January 2000, foaling has occurred over a significantly broader range than it had before the contraception program. Foaling in PZP recipients (n = 45 births from 27 mares) has consistently occurred over a broader range than has foaling in non-recipients (n = 52 births from 19 mares). In addition, current recipients of PZP foaled later in the year than did prior recipient and non-recipient mares. Females receiving more consecutive PZP applications gave birth later in the season than did females receiving fewer applications. Finally, the efficacy of PZP declined with increasing consecutive applications before reaching 100% after five consecutive applications. Conclusions/Significance For a gregarious species such as the horse, the extension of reproductive cycling into the fall months has important social consequences, including decreased group stability and the extension of male reproductive behavior. In addition, reproductive cycling into the fall months could have long-term effects on foal survivorship. Managers should consider these factors before enacting immunocontraceptive programs in new populations. We suggest minor alterations to management strategies to help alleviate such unintended effects in new populations. PMID:21049017

Bacterial carbohydrate-degrading capacity in foal faeces: changes from birth to pre-weaning and the impact of maternal supplementation with fermented feed products.

PubMed

Faubladier, Céline; Julliand, Véronique; Danel, Justine; Philippeau, Christelle

2013-09-28

The present study aimed at (1) describing age-related changes in faecal bacterial functional groups involved in carbohydrate degradation and in their activities in foals (n 10) from birth (day (d) 0) to 6 months (d180) and (2) investigating the effect of maternal supplementation (five mares per treatment) from d - 45 to d60 with fermented feed products on response trends over time of the foal bacterial carbohydratedegrading capacity. Maternal supplementation with fermented feed products stimulated foal growth from d0 to d60 and had an impact on the establishment of some digestive bacterial groups and their activities in foals from d0 to d5 but not in the longer term. Irrespective of the maternal treatment, total bacteria, total anaerobic, lactate-utilising and amylolytic bacteria were established immediately after birth (P<0·05) and were active as shown by the significant increase in total volatile fatty acids. In the foals of supplemented mares, total anaerobes and lactate utilisers were established rapidly between d0 and d2 (P=0·021 and 0·066, respectively) and the increase in the percentage of propionate occurred earlier (P=0·013). Maternal supplementation had no effect on the establishment of fibrolytic bacteria and their activity. Cellulolytic bacteria and Fibrobacter succinogenes first appeared at d2 and d5, and increased progressively, reaching stable values at d30 and d60, respectively. From the second week of life, the increase in the molar percentage of acetate and the ratio (acetate + butyrate):propionate (P<0·05) suggested that fibrolytic activity had begun. From d60, only minor changes in bacterial composition and activities occurred, showing that the bacterial carbohydrate-degrading capacity was established at 2 months of age.

Hematology, blood typing, and immunology of the neonatal foal.

PubMed

Becht, J L; Semrad, S D

1985-04-01

Hematologic parameters change during the first 10 days of life. Erythrocytes increase in number but decrease in size and hemoglobin concentration. The PCV, hemoglobin, and platelet count also decrease. Total blood and plasma volume and, to lesser extent, erythrocyte volume decrease. Normal neonatal foals may have immature neutrophils (up to 5 per cent bands), and their early rapid rise in neutrophil numbers may be accompanied by a lymphopenia. Monocytes, eosinophils, and basophils are all absent or low initially. Infectious processes can cause rapid and variable changes in the leukogram. However, elevation of fibrinogen levels may lag behind the development of an inflammatory process, and this parameter should not be relied on for early evidence of infection. After 12 hours of life, there is generally a decrease in serum concentrations of Na, Cl, iron, creatinine, BUN, plasma protein, and possibly calcium. LDH, SAP, P, bilirubin, and glucose concentrations are all higher in foals than in mature horses. Creatinine may actually be elevated during the first 12 hours of life and then decreases. If azotemia, hypochloremia, hyponatremia, and hyperkalemia are found, ruptured bladder with uroperitoneum should be suspected. The creatinine concentration is preferable to BUN determination for diagnosis of this condition. Blood typing is useful for diagnosis of NI, determination of blood compatability between donor and transfusion recipient, and for verification of parentage for breed registries. Several techniques are available. Several tests are available for evaluation of the foal's immunoglobulin levels and confirmation of passive antibody transfer. Because foals suffering from FPT are more predisposed to infections, their immunoglobulin status should be determined as early as possible so that additional colostrum or plasma can be administered as needed. Neonatal isoerythrolysis is uncommon but is an important immunologic syndrome that often results in a fatal hemolytic crisis. If one suspects the condition may be likely, the optimal time for testing the mare is during the last 2 weeks of gestation. If the foal's dam is shown to have alloantibodies against a panel of known erythrocyte alloantigens, prevention is possible by feeding colostrum from another mare. If a foal develops NI, further colostrum ingestion from the dam must be prevented. Good nursing care, minimizing stress, and adequate frequent feedings are essential; prophylactic antibiotics should be used, and transfusion may be necessary.

Verminous arteritis in a 3-month-old thoroughbred foal.

PubMed

DeLay, J; Peregrine, A S; Parsons, D A

2001-04-01

Strongylus vulgaris migration and cranial mesenteric arterial thrombus formation resulted in fatal colic in a 3-month-old Thoroughbred foal. Vascular damage associated with S. vulgaris occurs early in the course of infection and, despite widespread use of broad-spectrum anthelmintics, appropriate management is still essential to minimize exposure of young animals to this parasite.

Verminous arteritis in a 3-month-old thoroughbred foal.

PubMed Central

DeLay, J; Peregrine, A S; Parsons, D A

2001-01-01

Strongylus vulgaris migration and cranial mesenteric arterial thrombus formation resulted in fatal colic in a 3-month-old Thoroughbred foal. Vascular damage associated with S. vulgaris occurs early in the course of infection and, despite widespread use of broad-spectrum anthelmintics, appropriate management is still essential to minimize exposure of young animals to this parasite. PMID:11326632

"Growing Beyond Earth" Challenge Germinates in South Florida

NASA Image and Video Library

2017-09-30

Kennedy scientists Trent Smith, left, and Dr. Gioia Massa speak to middle and high school teachers at Fairchild Tropical Botanic Garden in Miami during the kickoff of the 2017-2018 Fairchild Challenge-Growing Beyond Earth. More than 130 teachers gathered for the opening workshop, where they learned about food production in space and the Veggie hardware currently on the International Space Station. NASA has partnered with Fairchild to create this STEM-based challenge in which students will follow specific research protocols and analyze plant growth factors, flavor and nutrition, in order to help NASA choose the next crops for astronauts to grow aboard the station.

Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes

PubMed Central

Zwart, Sara R.; Gregory, Jesse F.; Zeisel, Steven H.; Gibson, Charles R.; Mader, Thomas H.; Kinchen, Jason M.; Ueland, Per M.; Ploutz-Snyder, Robert; Heer, Martina A.; Smith, Scott M.

2016-01-01

Ophthalmic changes have occurred in a subset of astronauts on International Space Station missions. Visual deterioration is considered the greatest human health risk of spaceflight. Affected astronauts exhibit higher concentrations of 1-carbon metabolites (e.g., homocysteine) before flight. We hypothesized that genetic variations in 1-carbon metabolism genes contribute to susceptibility to ophthalmic changes in astronauts. We investigated 5 polymorphisms in the methionine synthase reductase (MTRR), methylenetetrahydrofolate reductase (MTHFR), serine hydroxymethyltransferase (SHMT), and cystathionine β-synthase (CBS) genes and their association with ophthalmic changes after flight in 49 astronauts. The number of G alleles of MTRR 66 and C alleles of SHMT1 1420 both contributed to the odds of visual disturbances. Preflight dehydroepiandrosterone was positively associated with cotton wool spots, and serum testosterone response during flight was associated with refractive change. Block regression showed that B-vitamin status and genetics were significant predictors of many of the ophthalmic outcomes that we observed. In one example, genetics trended toward improving (P = 0.10) and B-vitamin status significantly improved (P < 0.001) the predictive model for refractive change after flight. We document an association between MTRR 66 and SHMT1 1420 polymorphisms and spaceflight-induced vision changes. This line of research could lead to therapeutic options for both space travelers and terrestrial patients.—Zwart, S. R., Gregory, J. F., Zeisel, S. H., Gibson, C. R., Mader, T. H., Kinchen, J. M., Ueland, P. M., Ploutz-Snyder, R., Heer, M. A., Smith, S. M. Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. PMID:26316272

Temporal changes in concentrations of amino acids in plasma and whole blood of healthy neonatal foals from birth to two days of age.

PubMed

Zicker, S C; Rogers, Q R

1994-07-01

Temporal changes, as well as differences in distribution, in concentrations of 24 amino acids in plasma and whole blood of neonatal foals were determined from birth to 2 days of age. In addition, differences in concentrations of amino acids in plasma between mare and foal pairs were determined at birth. Significant (P < 0.05) hypoaminoacidemia existed for 15 amino acids in plasma of foals at birth, compared with mares (paired t-test). Concentrations of 7 amino acids (aspartate, glutamate, glutamine, glycine, hydroxyproline, phenylalanine, proline) in plasma of foals were higher (P < 0.05) at birth than in mares, and concentrations of 2 (taurine, tryptophan) were not different (P > 0.05). Significant (P < 0.05) temporal changes for concentrations of 19 of 24 amino acids in plasma were observed during the 48-hour period. Concentrations of 13 of the 19 amino acids in plasma that had significant changes were higher (P < 0.05) at 48 hours. Significant (P > 0.05) effect of time on concentration of 5 amino acids (alanine, methionine, phenylalanine, taurine, threonine) in plasma was not found after birth. Temporal changes in concentrations of 7 amino acids (alanine, asparagine, glutamine, histidine, hydroxyproline, methionine, and threonine) in whole blood were not significantly (P > 0.05) different from those in plasma. Temporal changes for concentrations of the remaining 17 amino acids in whole blood were significantly (P < 0.05) different, compared with plasma. Distribution of the concentrations of 18 amino acids between whole blood and plasma was significantly (P < 0.05) different.(ABSTRACT TRUNCATED AT 250 WORDS)

Meat quality of "Galician Mountain" foals breed. Effect of sex, slaughter age and livestock production system.

PubMed

Franco, Daniel; Rodríguez, Eva; Purriños, Laura; Crecente, Santiago; Bermúdez, Roberto; Lorenzo, José M

2011-06-01

The effects of sex, slaughter age (9 vs. 12 months) and livestock production system (freedom extensive system (FES) vs. semi extensive system (SES)) of "Galician Mountain" foals breed on meat quality from the Longissimus dorsi (LD) muscle were investigated. Forty-two foals had been used for this study, 19 (11 females and 8 males) were reared in a semi extensive system and weaned three months prior to slaughtering (8 and 11 were slaughtered at 9 and 12 months, respectively) while the other 23 (11 females and 12 males) were reared together with its mothers in a system in freedom and were slaughtered at the age of 9 months. The obtained results showed that there were no significant differences between the sexes and the slaughter age whereas the livestock production system was a significant variation source on intramuscular fat content and meat tenderness because SES foals showed 51.6% more of IMF and the improved meat tenderness achieved a shear force of <3 kg. In general, the meat from foals of the study at hand showed very lean meat (<0.3% in IMF) with a high protein content (>20.5%) and heme-iron (1.62 mg/100g meat) comparable to veal meat. Furthermore, the meat samples showed a higher luminosity (L*>40), a very good water holding capacity, measured by cooking losses (<18.3%), and a tenderness less than 4 kg. Thus, it can be classified as "very tender" meat. Copyright © 2011 Elsevier Ltd. All rights reserved.

Cloned foal derived from in vivo matured horse oocytes aspirated by the short disposable needle system

PubMed Central

Lee, Wonyou; Song, Kilyoung; Lee, Inhyung; Shin, Hyungdo; Lee, Byeong Chun

2015-01-01

Transvaginal ultrasound-guided follicle aspiration is one method of obtaining recipient oocytes for equine somatic cell nuclear transfer (SCNT). This study was conducted: (1) to evaluate the possibility of oocyte aspiration from pre-ovulatory follicles using a short disposable needle system (14-G) by comparing the oocyte recovery rate with that of a long double lumen needle (12-G); (2) to investigate the developmental competence of recovered oocytes after SCNT and embryo transfer. The recovery rates with the short disposable needle vs. the long needle were not significantly different (47.5% and 35.0%, respectively). Twenty-six SCNT embryos were transferred to 13 mares, and one mare delivered a live offspring at Day 342. There was a perfect identity match between the cloned foal and the cell donor after analysis of microsatellite DNA, and the mitochondrial DNA of the cloned foal was identical with that of the oocyte donor. These results demonstrated that the short disposable needle system can be used to recover oocytes to use as cytoplasts for SCNT, in the production of cloned foals and for other applications in equine embryology PMID:26119166

Effect of nutritive level on carcass traits and meat quality of IHDH foals

PubMed Central

De Palo, Pasquale; Tateo, Alessandra; Maggiolino, Aristide; Centoducati, Pasquale

2014-01-01

The present work describes the effect of nutritive level on horse carcass traits and on meat quality. Eighteen male Italian Heavy Draught Horse (IHDH) breed foals were employed in the study. Soon after foaling they were randomly subdivided into three groups according to three nutritive level classes: 150%, 180% and 200% of maintenance requirements. Live weight, hot carcass weight and dressing percentage of each animal were recorded. After slaughtering, meat samples were collected from Longissimus dorsi muscle. The right half carcass of each animal was then divided into cuts. Each one was subdivided into lean, fat and bones. Live weight, carcass weight and dressing percentage were not affected by nutritive level (P > 0.05). Horses fed with the lower nutritive level showed a higher incidence of lean and a lower incidence of fat (P < 0.01). Moreover, fatty acid profile was not affected by nutritive level (P > 0.05). Probably the tendency of IHDH foals to concentrate adipogenesis in the subcutaneous district could explain the lack of influence of nutritive level on meat quality parameters and its influence on carcass and cut composition, which tend to be richer in fat. PMID:24961285

KSC-97PC1352

NASA Image and Video Library

1997-09-09

STS-86 crew members get a ride in, and learn to operate, an M-113 armored personnel carrier as part of training exercises during the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. George Hoggard, in back at left, a training officer with KSC Fire Services, provides this part of the training to Mission Specialists Wendy B. Lawrence, to the right of Hoggard; Vladimir Georgievich Titov of the Russian Space Agency; and Scott E. Parazynski. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Titov and Parazynski are scheduled to conduct a spacewalk primarily to retrieve four suitcase-sized environmental payloads from the exterior of the Mir docking module. Also during the mission, STS-86 Mission Specialist David A. Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25 from Launch Pad 39A

KSC-97pc673

NASA Image and Video Library

1997-04-19

KENNEDY SPACE CENTER, FLA. -- McDonnell Douglas-SPACEHAB technicians oversee the move of a Russian-made oxygen generator to a SPACEHAB Double Module, at rear, in the SPACEHAB Payload Processing Facility. With faces visible in center foreground, from left, are Mark Halavin and Marc Tuttle; Mike Vawter is at far right. The oxygen generator, manufactured in Russia by RSC Energia, will be carried aboard the Space Shuttle Atlantis on Mission STS-84 for the Shuttle’s scheduled docking with the Russian Space Station Mir next month. The nearly 300-pound generator will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking

Immunoturbidimetric quantification of serum immunoglobulin G concentration in foals.

PubMed

Bauer, J E; Brooks, T P

1990-08-01

Immunoturbidimetric determination of serum IgG concentration in foals was compared with the reference methods of single radial immunodiffusion and serum protein electrophoresis. High positive correlations were discovered when the technique was compared with either of these reference methods. The zinc sulfate turbidity test for serum IgG estimation was also evaluated. Although a positive correlation was discovered when the latter method was compared with reference methods, it was not as strong as the correlation between reference methods and the immunoturbidimetric method. The immunoturbidimetric method used in this study is specific and precise for equine serum IgG determination. It is rapid and, thus, is advantageous when timely evaluation of critically ill foals is necessary. The technique should be adaptable to various spectrophotometers and microcomputers for widespread application in veterinary medicine.

Retrospective and statistical analysis of breeding management on the Italian Heavy Draught Horse breed.

PubMed

Mantovani, R; Sartori, C; Pigozzi, G

2013-07-01

This study investigated some aspects of breeding management in the Italian Heavy Draught Horse breed, aiming at improving its efficiency at stud farm level. A first aim was to evaluate the risk of unsuccessful reproduction in mares after an early (3 years) or normal (4 years) age at first foaling, in interaction with different stud rearing systems. A second objective was the examination of the mean time length in which young 2-year-old stallions maintain a genetic superiority on older proven stallions, identifying a 'genetic lifespan' in which young stallions can be safely used for reducing the cost of services. Reproductive performance at first and second foaling of 1513 mares were used. Mares had a normal first foal at 3 (n = 745) or 4 years of age (n = 768) in stud farms on the basis of stable (n = 488), feral (n = 345) or semi-feral (n = 680) rearing systems. Logistic regression analysis was performed by modeling the risk of unsuccessful reproduction in the subsequent season (i.e., results at second foaling), as affected by the interaction of age at first foaling × rearing system (six classes). Genetic lifespan of young stallions was estimated by regressing the least square means from a mixed model analysis for repeated measures of individual differences in 'total merit' estimated breeding values (EBVs) between young stallions (mean no. of 45/year) and the mean EBV of all proven stallions in a given year of genetic evaluation (mean no. of 483/year). Young stallions born between 1999 and 2005 were used, following each generation (i.e., birth year) from 2 to 7 subsequent yearly genetic evaluations. In comparison with the best reproductive success of second foaling at 4 years in stable systems, the greatest risk of unsuccessful reproduction was at 3 years in feral (+167%) and 3 years in semi-feral conditions (+91%). Young stallions showed a 0.50 s.d. greater EBV at the first evaluation than proven stallions, with a mean annual decrease in EBV of 0.07 s.d./year on proven stallions. Optimal breeding management could be obtained in stud farms by limiting foaling at 3 years, particularly in feral and semi-feral rearing systems, and using young stallions for 3 to 4 years to maintain a perceptible selection differential with older proven stallions and to reduce cost of services. Later, the selection differential with proven stallions become less consistent and genetic improvement could be slowed down.

Increased serum nonesterified fatty acid and low ionised calcium concentrations are associated with post partum colic in mares.

PubMed

Holcombe, S J; Embertson, R M; Kurtz, K A; Roessner, H A; Wismer, S E; Geor, R J; Kaneene, J B

2016-01-01

Increased serum nonesterified fatty acids (NEFA) and decreased serum electrolytes are linked to abdomasal displacements in post partum dairy cattle. Post partum colic in mares may be associated with metabolic changes specific to pregnancy and the periparturient period. To determine if fluctuations in serum NEFA, ionised calcium (iCa) and magnesium (iMg) occurred in periparturient mares and if these alterations were associated with post partum colic. Longitudinal observational study. Mares from 3 farms in central Kentucky were enrolled. Blood samples were collected 14 days prior to the estimated foaling date, within 4 days post parturition, and 14 and 28 days after foaling for batch analysis of serum NEFA, iCa and iMg. Health information was provided by farm managers and veterinarians. Data were analysed using Kruskal-Wallis χ(2) statistic for nonparametric data and a matched case/control approach. Repeated measures logistic regression models were developed. Serum NEFAs were higher at 14-1 day before foaling (mean ± s.d., mmol/l), 0.28 ± 0.12, P = 0.04 and from foaling to 4 days after foaling, 0.29 ± 0.20 (P = 0.05) in mares that developed colic compared with those that did not colic, 0.19 ± 0.05 and 0.21 ± 0.14, respectively. Ionised calcium was lower at 15-28 days post foaling in mares that showed colic, 1.50 ± 0.17 compared to mares that did not colic, 1.60 ± 0.12, P = 0.02. Risk of colic in post partum mares increased 38% for each 0.1 mmol/l increase in serum NEFA (odds ratio = 1.38, 95% confidence interval 1.06-1.81, P = 0.02). Mares with post partum colic had significantly higher serum NEFA and lower iCa prior to the colic episode compared with mares that did not develop colic. Monitoring these metabolic alterations may lead to predictive and preventive colic strategies for post partum mares. © 2015 EVJ Ltd.

Effects of age and season on haematological parameters of donkeys during the rainy and cold-dry seasons.

PubMed

Zakari, Friday Ocheja; Ayo, Joseph Olusegun; Rekwot, Peter Ibrahim; Kawu, Mohammed Umar

2015-12-01

The aim of the study was to investigate the effects of age and season on haematological parameters of donkeys at rest during the rainy and cold-dry seasons. Thirty healthy donkeys divided into three groups based on their age served as the subjects. During each season, blood sample was collected from each donkey thrice, 2 weeks apart, for haematological analysis, and the dry-bulb temperature (DBT), relative humidity (RH) and temperature-humidity index (THI) were obtained thrice each day during the experimental period using standard procedures. During the rainy season, the mean DBT (33.05 ± 0.49 °C), RH (73.63 ± 1.09 %) and THI (84.39 ± 0.71) were higher (P < 0.0001) than the corresponding values of 24.00 ± 0.44 °C, 36.80 ± 0.92 % and 64.80 ± 0.62, during the cold-dry season. Packed cell volume (PCV), erythrocyte count [red blood cell (RBC)], haemoglobin concentration (Hb), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), platelet count (PLT), leucocyte count [white blood cell (WBC)], lymphocyte count (LYM) and neutrophil/lymphocyte ratio (N/L) were higher (P < 0.05) in adults than foals during the rainy season. The MCV, MCH, WBC, NEU, LYM and PLT of adult and yearling donkeys were higher (P < 0.05) during the rainy than the cold-dry season. The PCV, RBC, Hb, MCV, MCH, and NEU of foals were higher in the rainy than the cold-dry season. The N/L of adult and foal donkeys were higher (P < 0.05) in the rainy than in the cold-dry season. In conclusion, PCV, RBC, Hb and LYM were considerably higher in foals than yearlings or adults during the rainy season, while erythrocytic indices and platelet counts were higher in adults or yearlings than in foals in both seasons. Erythrocytic indices, PLT and N/L were higher in the rainy than the cold-dry season in adults, yearlings and foals.

KSC-99pp1474

NASA Image and Video Library

1999-12-19

Turning night into day for a few moments while belching clouds of smoke and steam, Space Shuttle Discovery hurtles into the black sky on mission STS-103. The successful liftoff occurred at 7:50 p.m. EST from Launch Pad 39B. On board are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. STS-103 is a Hubble Servicing Mission, with three planned space walks designed to install new equipment and replace old. The primary objective is to replace the gyroscopes that make up the three Rate Sensor Units. Extravehicular activities include installing a new computer, changing out one of the Fine Guidance Sensors, replacing a tape recorder with a new solid state recorder, and installing a voltage/temperature improvement kit, and begin repairing the insulation on the telescope's outer surface. After the 7-day, 21-hour mission, Discovery is targeted to land at KSC Monday, Dec. 27, at about 5:24 p.m. EST. This is the 27th flight of Discovery and the 96th mission in the Space Shuttle Program. It is the third launch at Kennedy Space Center in 1999

STS-103 Mission Specialist Grunsfeld and his family DEPART PAFB for Houston

NASA Technical Reports Server (NTRS)

1999-01-01

STS-103 Mission Specialist John M. Grunsfeld (Ph.D.), with his wife, Carol, and their children, smiles for the camera on the runway at Patrick Air Force Base in Cocoa Beach, Fla. The STS-103 crew and their families are preparing to board an airplane that will return them to their home base at the Johnson Space Center in Houston following the successful completion of their mission. Discovery landed in darkness the previous evening, Dec. 27, on runway 33 at KSC's Shuttle Landing Facility at 7:00:47 p.m. EST. This was the first time that a Shuttle crew spent the Christmas holiday in space. The other STS-103 crew members are Commander Curtis L. Brown Jr.; Pilot Scott J. Kelly; and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France. The STS-103 mission accomplished outfitting the Hubble Space Telescope with six new gyroscopes, six new voltage/temperature improvement kits, a new onboard computer, a new solid state recorder and new data transmitter, a new fine guidance sensor along with new insulation on parts of the orbiting telescope. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery.

STS-103 crew members and their families pose for a portrait before DEPARTing

NASA Technical Reports Server (NTRS)

1999-01-01

The STS-103 crew pose for a group portrait with their families and loved ones on the runway at Patrick Air Force Base in Cocoa Beach, Fla. They are preparing to board an airplane that will return them to their home base at the Johnson Space Center in Houston following the successful completion of their mission. From left to right, the crew members are Mission Specialists John M. Grunsfeld (Ph.D.), C. Michael Foale (Ph.D.), Claude Nicollier of Switzerland, Jean-Frangois Clervoy of France, and Steven L. Smith; Pilot Scott J. Kelly; and Commander Curtis L. Brown Jr. Discovery landed in darkness the previous evening, Dec. 27, on runway 33 at KSC's Shuttle Landing Facility at 7:00:47 p.m. EST. This was the first time that a Shuttle crew spent the Christmas holiday in space. The STS-103 mission accomplished outfitting the Hubble Space Telescope with six new gyroscopes, six new voltage/temperature improvement kits, a new onboard computer, a new solid state recorder and new data transmitter, a new fine guidance sensor along with new insulation on parts of the orbiting telescope. This was the 96th flight in the Space Shuttle program and the 27th for the orbiter Discovery.

STS-103 crew take part in CEIT

NASA Technical Reports Server (NTRS)

1999-01-01

In the Payload Hazardous Servicing Facility, some of the STS-103 crew look over lubrication devices to be used during their mission. The seven-member crew are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-Frangois Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a 'call-up' due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review.

KSC-99pp1087

NASA Image and Video Library

1999-09-02

In the Payload Hazardous Servicing Facility, some of the STS-103 crew look over lubrication devices to be used during their mission. The seven-member crew are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a "call-up" due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review

Evaluation of five commercially available assays and measurement of serum total protein concentration via refractometry for the diagnosis of failure of passive transfer of immunity in foals.

PubMed

Davis, Rachel; Giguère, Steeve

2005-11-15

To determine and compare sensitivity, specificity, accuracy, and predictive values of measurement of serum total protein concentration by refractometry as well as 5 commercially available kits for the diagnosis of failure of passive transfer (FPT) of immunity in foals. Prospective study. 65 foals with various medical problems and 35 clinically normal foals. IgG concentration in serum was assessed by use of zinc sulfate turbidity (assay C), glutaraldehyde coagulation (assay D), 2 semiquantitative immunoassays (assays F and G), and a quantitative immunoassay (assay H). Serum total protein concentration was assessed by refractometry. Radial immunodiffusion (assays A and B) was used as the reference method. For detection of IgG < 400 mg/dL, sensitivity of assay H (100%) was not significantly different from that of assays C, E, and G (88.9%). Specificity of assays H (96.0%) and G (95.8%) was significantly higher than that of assays C (79.4%) and E (78.1 %). For detection of IgG < 800 mg/dL, sensitivities of assays H (976%), D (92.9%), C (81.0%), and G (81.0%) were significantly higher than that of assay F (52.4%). Specificity of assays F (100%), G (94.7%), and H (82.8%) was significantly higher than that of assays C (56.9%) and D (58.6%). Serum total protein concentration < or = 4.5 g/dL was suggestive of FPT, whereas values > or = 6.0 g/dL indicated adequate IgG concentrations. Most assays were adequate as initial screening tests. However, their use as a definitive test would result in unnecessary treatment of foals with adequate IgG concentrations.

Correlation of serum IgG concentration in foals and refractometry index of the dam's pre- and post-parturient colostrums: an assessment for failure of passive transfer in foals.

PubMed

Korosue, Kenji; Murase, Harutaka; Sato, Fumio; Ishimaru, Mutsuki; Kotoyori, Yasumitsu; Nambo, Yasuo

2012-11-01

The object of this study was to evaluate the usefulness of measuring the differences in the values of the serum total protein (DVSTP) concentration of foals and the refractometry index (DVRI) of the milk of dams before and after nursing of the colostrum for assessing failure of passive transfer (FPT) in foals. Serum samples from 31 foals were collected before the first nursing and other 1 to 6 times between 4 and 24 hr after birth. Paired colostrum and milk samples were collected from 14 of their dams at the same time. Serum samples were analyzed for IgG concentration using a single radial immunodiffusion (SRID) test (98 samples) and total protein concentration using a temperature-compensating refractometer (98 samples). Colostrum and milk samples were analyzed for refractometry index (RI) using a Brix refractometer (71 samples). DVSTP concentration and DVRI were significantly correlated with serum IgG concentration. The negative predictive values (NPVs) of DVSTP concentration for detecting serum IgG concentrations<400 mg/dl and<800 mg/dl were 98.2% and 91.3% when the cutoff value is set to 0.4 mg/dl and 0.8 mg/dl, respectively. Furthermore, the NPVs of DVRI for detecting serum IgG concentrations<400 mg/dl and<800 mg/dl were 97.3% and 96.3% when the cutoff value is set to 6% and 10%, respectively. The results suggest that measurement of DVRI is useful in assessing FPT as an initial "stall-side" screening test, because it is easy, inexpensive to perform and allows for rapid interpretation.

Agreement between arterial partial pressure of carbon dioxide and saturation of hemoglobin with oxygen values obtained by direct arterial blood measurements versus noninvasive methods in conscious healthy and ill foals.

PubMed

Wong, David M; Alcott, Cody J; Wang, Chong; Bornkamp, Jennifer L; Young, Jessica L; Sponseller, Brett A

2011-11-15

To determine agreement between indirect measurements of end-tidal partial pressure of carbon dioxide (PetCO(2)) and saturation of hemoglobin with oxygen as measured by pulse oximetry (SpO(2)) with direct measurements of PaCO(2) and calculated saturation of hemoglobin with oxygen in arterial blood (SaO(2)) in conscious healthy and ill foals. Validation study. 10 healthy and 21 ill neonatal foals. Arterial blood gas analysis was performed on healthy and ill foals examined at a veterinary teaching hospital to determine direct measurements of PaCO(2) and PaO(2) along with SaO(2). Concurrently, PetCO(2) was measured with a capnograph inserted into a naris, and SpO(2) was measured with a reflectance probe placed at the base of the tail. Paired values were compared by use of Pearson correlation coefficients, and level of agreement was assessed with the Bland-Altman method. Mean ± SD difference between PaCO(2) and PetCO(2) was 0.1 ± 5.0 mm Hg. There was significant strong correlation (r = 0.779) and good agreement between PaCO(2) and PetCO(2). Mean ± SD difference between SaO(2) and SpO(2) was 2.5 ± 3.5%. There was significant moderate correlation (r = 0.499) and acceptable agreement between SaO(2) and SpO(2). Both PetCO(2) obtained by use of nasal capnography and SpO(2) obtained with a reflectance probe are clinically applicable and accurate indirect methods of estimating and monitoring PaCO(2) and SaO(2) in neonatal foals. Indirect methods should not replace periodic direct measurement of corresponding parameters.

A free-ranging, feral mare equus caballus affords similar maternal care to her genetic and adopted offspring.

PubMed

Nuñez, Cassandra M V; Adelman, James S; Rubenstein, Daniel I

2013-11-01

Adoption of nongenetic offspring occurs in a variety of species but is rare in equids. We report a case of adoption by a free-ranging, feral mare Equus caballus and compare the maternal care received by her genetic offspring (born 1995) to that of her adopted offspring (born 1996) for the first 30 weeks of development. We compare five measures of care: (1) total time spent suckling, (2) mare aggression during suckling, (3) number of mare-terminated suckling bouts, (4) contact maintenance, and (5) mare-foal distance. For most behaviors, we detected no difference in the mare's treatment of the two foals; however, mare-foal distance was greater for the genetic offspring. We compare hypotheses regarding the reasons for adoption, offering postpartum physiological state as a potential driver.

Risk of transplacental transmission of Sarcocystis neurona and Neospora hughesi in California horses.

PubMed

Duarte, Paulo C; Conrad, Patricia A; Barr, Bradd C; Wilson, W David; Ferraro, Gregory L; Packham, Andrea E; Carpenter, Tim E; Gardner, Ian A

2004-12-01

The study objective was to assess the risk of transplacental transmission of Sarcocystis neurona and Neospora hughesi in foals from 4 California farms during 3 foaling seasons. Serum of presuckle foals and serum and colostrum of periparturient mares were tested using indirect fluorescent antibody tests for S. neurona and N. hughesi. Serum antibody titers were < or =10 in 366 presuckle foals tested. There was no serologic or histologic evidence of either parasite in aborted fetuses or placentas examined. Positivity for S. neurona and N. hughesi in mares increased with age. Mares < or =9 yr that originated from Kentucky were 3.8 and 1.4 times more likely to be positive for S. neurona and N. hughesi, respectively, than mares from California. The strength of association between positivity to either parasite and state of birth decreased as age increased. Mares positive for S. neurona and N. hughesi were 2.2 and 1.7 times more likely, respectively, to have a previous abortion than negative mares, adjusted for age and state of birth. The annual mortality rate for mares was 4%. The annual incidence rate of equine protozoal myeloencephalitis was 0.2%. In conclusion, there was no detectable risk of transplacental transmission of S. neurona and N. hughesi. Prevalence of antibodies against both parasites in mares increased with age.

Effect of nutritive level on carcass traits and meat quality of IHDH foals.

PubMed

De Palo, Pasquale; Tateo, Alessandra; Maggiolino, Aristide; Centoducati, Pasquale

2014-07-01

The present work describes the effect of nutritive level on horse carcass traits and on meat quality. Eighteen male Italian Heavy Draught Horse (IHDH) breed foals were employed in the study. Soon after foaling they were randomly subdivided into three groups according to three nutritive level classes: 150%, 180% and 200% of maintenance requirements. Live weight, hot carcass weight and dressing percentage of each animal were recorded. After slaughtering, meat samples were collected from Longissimus dorsi muscle. The right half carcass of each animal was then divided into cuts. Each one was subdivided into lean, fat and bones. Live weight, carcass weight and dressing percentage were not affected by nutritive level (P>0.05). Horses fed with the lower nutritive level showed a higher incidence of lean and a lower incidence of fat (P<0.01). Moreover, fatty acid profile was not affected by nutritive level (P>0.05). Probably the tendency of IHDH foals to concentrate adipogenesis in the subcutaneous district could explain the lack of influence of nutritive level on meat quality parameters and its influence on carcass and cut composition, which tend to be richer in fat. © 2014 The Authors. Animal Science Journal published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Society of Animal Science.

Effect of different cooking methods on lipid oxidation and formation of volatile compounds in foal meat.

PubMed

Domínguez, Rubén; Gómez, María; Fonseca, Sonia; Lorenzo, José M

2014-06-01

The influence of four different cooking methods (roasting, grilling, microwaving and frying) on cooking loss, lipid oxidation and volatile profile of foal meat was studied. Cooking loss were significantly (P<0.001) affected by thermal treatment, being higher (32.5%) after microwaving and lower after grilling (22.5%) and frying (23.8%). As expected, all the cooking methods increased TBARs content, since high temperature during cooking causes increased oxidation in foal steaks, this increase was significantly (P<0.001) higher when foal steaks were microwaved or roasted. The four different cooking methods led to increased total volatile compounds (between 366.7 and 633.1AU×10(6)/g dry matter) compared to raw steaks (216.4AU×10(6)/g dry matter). The roasted steaks showed the highest volatile content, indicating that increased cooking temperature increases the formation of volatile compounds. Aldehydes were the most abundant compounds in cooked samples, with amounts of 217.2, 364.5, 283.5 and 409.1AU×10(6)/g dry matter in grilled, microwaved, fried and roasted samples, respectively, whereas esters were the most abundant compounds in raw samples, with mean amounts of 98.8AU×10(6)/g dry matter. Copyright © 2014 Elsevier Ltd. All rights reserved.

Transmission of endoparasites in horse foals born on the same pasture on a farm in central Kentucky (1996-1999).

PubMed

Lyons, E T; Tolliver, S C; Collins, S S; Drudge, J H

2001-05-22

Research carried out during the last 4 years (1996-1999) of an 11-year study of the prevalence of internal parasites naturally transmitted to horse foals born on the same pasture on a farm in central Kentucky is presented here. Horses in this herd were not treated with any antiparasitic compound for over 20 years except for a replacement stallion in 1994. A total of 22 species, including 12 species of small strongyles, were recovered in the 4-year period. Transmission patterns of all species (n=35) of endoparasites recovered are compared for the 11-year study. Some of the changes were an increase in number of Thelazia lacrymalis and Anoplocephala perfoliata and a decrease in Gasterophilus intestinalis, Parascaris equorum, and Strongylus vulgaris. Clinical problems associated with parasitism were not observed in any of the 92 foals in the long-term investigation.

Bilateral renal dysplasia with nephron hypoplasia in a foal.

PubMed

Zicker, S C; Marty, G D; Carlson, G P; Madigan, J E; Smith, J M; Goetzman, B W

1990-06-15

Bilateral renal dysplasia and nephron hypoplasia was diagnosed in a Quarter Horse foal with clinical signs of lethargy, convulsions, and diarrhea. Laboratory evaluation revealed anemia, hypoproteinemia, leukopenia, hyponatremia, hypochloremia, and hyposmolality. The foal also had high concentrations of serum creatinine, BUN, and phosphorus. Evaluation of urinary indices revealed a high ratio of urinary gamma-glutamyl-transferase activity to concentration of creatinine, as well as a high fractional clearance ratio of sodium and potassium. Intravenous treatment with saline solution (0.9% NaCl) and antimicrobials provided only temporary resolution of some of the abnormalities. Diagnosis was partly established by histologic evaluation of renal tissue obtained via an ultrasonographically guided biopsy and was confirmed at necropsy. Pathologic changes in the kidney were unique in that the size of the kidneys, along with the appearance and number of glomeruli, were essentially normal despite marked hypoplasia of nephron tubules in the medulla.

Artificially extended photoperiod administered to pre-partum mares via blue light to a single eye: Observations on gestation length, foal birth weight and foal hair coat at birth.

PubMed

Nolan, Margaret B; Walsh, Caroline M; Duff, Noelle; McCrarren, Conor; Prendergast, Ralph L; Murphy, Barbara A

2017-09-15

In seasonally breeding animals, photoperiod perception is crucial for timing of important physiological events. In the horse, long day photoperiod influences the onset of ovulation and cyclicity, shedding of the heavier winter coat and the timing of parturition. In this compilation of studies, conducted across three breeding seasons and two countries, the impact of artificially extended day length was investigated on gestation length, foal birth weight and foal hair coat at birth. The light therapy was administered to pre-partum mares via mobile head worn masks which provided short wavelength blue light to a single eye. In Study 1, reductions in gestation lengths were observed following administration of artificially extended day length (124.8 ± 15.11 days) in the final months of pregnancy to a group of Thoroughbred mares compared to controls (P < 0.05; 339.7 ± 9.56 days vs 350.6 ± 9.13). Study 2 revealed that pre-partum exposure to artificially extended day length (104.6 ± 9.89 days) increased foal birth weight compared to controls (47.13 ± 2.93 kg vs 43.51 ± 6.14 kg; P < 0.05) in mares bred early in the year. In Study 3, artificially extended day length (87.53 ± 19.6 days) administered to pre-partum mares affected the coat condition of foals at birth with respect to hair weight (P < 0.0001) and hair length (P < 0.0001) compared to controls (0.34 ± 0.20 μg vs 0.59 ± 0.12 μg and 1.93 ± 0.56 cm vs 2.56 ± 0.32 cm, respectively). Collectively, these studies serve to highlight the influential role of the circa-annual changes in photoperiod length on the pre-partum mare for normal foetal development during the natural breeding season. It also emphasizes the potential that exists to improve breeding efficiency parameters by artificially simulating this important environmental cue in the latter stages of gestation against the backdrop of an economically driven early breeding season. Copyright © 2017 Elsevier Inc. All rights reserved.

[Influence of the amount of concentrate feeding on concentrate intake and development of body weight and growth parameters of suckling foals from birth until the 6th month of life].

PubMed

Mack, J K; Remler, H P; Senckenberg, E; Kienzle, E

2012-01-01

The objective of this study was to investigate the effects of a different energy supply on the development of Warmblood foals with a focus on examining the recommended allowances of the German Society for Nutrition Physiology. Two groups of foals received different amounts of concentrates from the 1st until the 6th month of life. With regards to the total energy content, the rations were composed to either comply with the recommendations (6) (group "Norm", n=15) or to exceed those by approximately 20% (group "Zulage", n=16). The supply with concentrates of the group "Norm" aimed for a total energy intake of 73 MJ DE/animal/day, the intake of the group "Zulage" of 87 MJ DE/animal/day. Both groups were provided with the same amount of foal starter feed, but different amounts of oats. Both groups were supplied with 1.0, 1.2, 2.0, 2.0 and 2.35 kg foal starter feed per animal and day from the 2nd until the 6th month of life. Additionally, 0.6, 0.7, 0.5, 0.8 and 0.45 kg oats per animal and day (group "Norm") and 1.8, 2.0, 1.75, 2.0 and 1.75 kg (group "Zulage") were offered during months 2 to 6. The animals were fed twice daily. The roughage consisted of a late first cut of haylage. The animals were out to pasture for several hours/day. Individual concentrate intake, body mass and body condition score (BCS) as well as several other growth parameters were recorded. The total amount of haylage consumed by all animals was documented. The daily average intake of concentrates lay between 0.4 ("Norm") and 0.5 kg ("Zulage") in the 2nd month and between 2.8 ("Norm") and 3.7 kg ("Zulage") in the 6th month. The groups did not differ in any recorded parameter. The amount of concentrates offered was entirely eaten for the first time at an age of approximately 180 days. The results suggest that the energy requirements of foals are approximately 10-20% lower than the recommendations.

European astronaut selected for the third Hubble Space Telescope

NASA Astrophysics Data System (ADS)

1998-08-01

The STS-104 crew will rendezvous with the orbiting Hubble Space Telescope, which is the size of a city bus, capture it using the Shuttle's Canadian robot arm and secure it in Columbia's payload bay. Then, working in teams of two, the four astronauts will leave the Shuttle's pressurised cabin and venture into the payload bay, performing a variety of tasks that will improve the productivity and reliability of the telescope. The four astronauts will perform a series of six "extravehicular" activities in the open space environment. Such activities are commonly called spacewalks, but this term does little justice to the considerable physical and mental efforts that astronauts need to make in doing the very demanding work involved. The Shuttle commander and pilot for this flight have not yet been appointed, but the four designated mission specialists begin training for the STS-104 mission immediately. "The ambitious nature of this mission, with its six spacewalks, made it important for the payload crew to begin training as early as possible," said David C. Leestma, NASA Director of Flight Crew Operations at the Johnson Space Center in Houston, to which Claude Nicollier is on resident assignment from ESA's European Astronaut Centre in Cologne, Germany, the home base of the European astronaut corps. The Hubble Space Telescope was launched into orbit in April 1990. It is one of the most capable optical telescopes available to astronomers today, producing images and spectral observations at the forefront of astronomy. The European Space Agency contributed a 15 share to the development of Hubble. One of the five scientific instruments on board, the Faint Object Camera, was built by a European industrial consortium made up of British Aerospace, Dornier and Matra under a contract with the European Space Agency. The solar arrays which provide Hubble with electrical power were manufactured by British Aerospace and Dornier. In its eight years of operation, the telescope has not only observed relatively near celestial objects, like the planets in our solar system, but also looked thousands of millions of light years into space, taking images of the most distant galaxies ever seen. "The observations and spectral measurements taken with Hubble have improved our understanding of the origin and age of the universe. In some cases, the Hubble Space Telescope has already changed our thinking about the evolution of planetary systems, stars and galaxies," points out Roger Bonnet, ESA's Director of Science. Astronomers throughout the world are using the telescope. European astronomers have a significant share in the scientific utilisation of Hubble. The Space Telescope Science Institute in Baltimore, USA, coordinates and schedules the various observations. Europe's centre for coordinating observations from Hubble, the Space Telescope European Coordination Facility, is located at the Headquarters of the European Southern Observatory (ESO) at Garching, near Munich, Germany. The Hubble Space Telescope is the first spacecraft ever built that has been designed for extensive in-orbit maintenance and refurbishment by astronauts. Unlike other satellites launched on unmanned rockets, Hubble is accessible by astronauts in orbit. It has numerous grapple fixtures and handholds for ease of access and the safety of astronauts. Hence the telescope's planned 15-year continuous operating time, despite the harsh environmental conditions, and the ability to upgrade it with more powerful instruments as technology progresses. At regular intervals of 3 to 4 years, the US Space Shuttle visits the telescope in orbit to replace components which have failed or reached the nominal end of their operational lifetime and to replace and upgrade instruments with newer, better ones. STS-104 will be the third Hubble servicing mission, after STS-61 in December 1993 and STS-82 in February 1997. To increase Hubble's scientific capability, Nicollier and his fellow crew members from NASA will remove the European-built Faint Object Camera, which has been working without any problem since the launch in 1990, and replace it with a new-generation instrument, called the Advanced Camera for Survey. With its three electronic cameras and complement of filters, this camera is expected to improve the telescope's sensitivity tenfold. Other primary tasks to be accomplished during STS-104 mission include replacement of the existing solar arrays with rigid, high-efficiency arrays for which ESA will deliver the mechanisms, manufactured by Daimler-Benz Aerospace/Dornier. In common with optical instruments, solar arrays gradually decline in performance when exposed to the space environment. Further tasks are the replacement of a mechanical tape recorder with a new-generation solid-state recorder and the replacement of Fine Guidance Sensor no. 2, one of three such devices that help to point the telescope at a celestial target with an accuracy of 0.007 arc seconds. This is equivalent to keeping the telescope pointed at a candle in Amsterdam from Vevey, Switzerland, about 700 km away, where Nicollier was born. The crew will also install a cooling system to improve the thermal protection of some of the telescope's systems, a new-technology cryogenic cooler for the Near Infrared Camera and Mutli-Object Spectrometer instrument and six improvement kits which will enhance Hubble's battery charge capability. In addition, they will repair and replace much of the multi-layer exterior thermal insulation on the sun-facing side of the telescope. On the second Hubble servicing mission, STS-82 in February 1997, the crew noticed peeling on several areas of the insulation and applied four patches to the worst affected areas. Both Smith and Nicollier have previous in-flight experience with Hubble: Smith performed three extravehicular sorties during the STS-82 mission to Hubble and Nicollier operated the Shuttle's Canadian robot arm during the first servicing mission on the STS-61 mission in 1993. Foale has conducted extravehicular activities from both the Space Shuttle and the Russian Mir space station. Grunsfeld has two previous spaceflights to his credit. For Nicollier, who was selected by ESA in 1978 in the first group of European astronauts, it will be the fourth flight into space, more than any other European astronaut to date. Prior to taking part in the first Hubble servicing mission in December 1993, he was a mission specialist on the August 1992 STS-46 mission during which Eureca - the European retrievable experiment platform - was deployed and the first Tethered Satellite System test flight conducted. In February 1996 he participated in STS-75, which carried the US Microgravity Payload experiments and the second flight test of the Tethered Satellite System. Nicollier, who is delighted and honoured to be reassigned to a Hubble servicing mission, points out: "obviously, it makes sense to take advantage of our previous training and mission-specific experience to increase the likelihood of success, but it will nevertheless be a complex and demanding flight. 'Routine' is a word that has no place in astronaut's vocabulary." With three previous space missions, Nicollier is thoroughly experienced in the operation of the Shuttle's robotic arm and the procedures associated with meeting, capturing and redeploying free-flying platforms from the US Space Shuttle. Regular contacts with European development engineers ensure that Nicollier's experience from the Shuttle missions will also flow into the development of European elements for the International Space Station, most notably the Automated Transfer Vehicle and the European Robotic Arm. "Together with the selection of Pedro Duque for the STS-95 mission in October this year, and others we confidently expect in the future, the selection of Claude Nicollier, who is one of ESA's most experienced astronauts, is a clear signal of the high esteem in which NASA holds high professional skills and human qualities of Claude and the other European astronauts. This is a sound basis for fruitful cooperation of mutual benefit on the International Space Station, where astronauts from the USA, Russia, Europe, Japan and Canada will work together closely as a single integrated crew. It is also very useful to the development work on the European-built Station elements," comments Jörg Feustel-Büechl, who, as ESA Director of Manned Spaceflight and Microgravity, is responsible not only for the European astronaut corps but for the European participation in the International Space Station as well. Feustel-Büechl also points out that "the Hubble servicingmission shows that men and women can significantly augment the efficiency and lifetime of complex systems in space. Humans have two essential 'built-in tools' which make them superior to any robot: their brain and their hands. No robot offers a comparable combination of high intelligence, adaptability to unexpected situations, mobility, dexterity and tactility. Robotic systems can perform pre-defined routine tasks and even support astronauts in their work, as the Shuttle's robotic arm shows, but they soon reach their inherent limitations when it comes to evaluating results and deciding what to do next. That is one of the key reasons why we are building and operating a manned space station." Additional information on Claude Nicollier, his NASA crewmates, the Hubble Space Telescope, the International Space Station and Europe's participation in the ISS programme can be found at the following Internet addresses: ESA astronauts: http://www.estec.esa.int/spaceflight/astronaut/ NASA astronauts: http://www.jsc.nasa.gov/Bios/ Hubble Space Telescope: http://sci.esa.int/hubble/ http://oposite.stsci.edu http://www.stsci.edu http://ecf.hq.eso.org International Space Station: http://station.nasa.gov European participation in the International Space Station: http://www.estec.esa.int/spaceflight More information on ESA can be found at: http://www.esa.int

Glycogen branching enzyme (GBE1) mutation causing equine glycogen storage disease IV.

PubMed

Ward, Tara L; Valberg, Stephanie J; Adelson, David L; Abbey, Colette A; Binns, Matthew M; Mickelson, James R

2004-07-01

Comparative biochemical and histopathological evidence suggests that a deficiency in the glycogen branching enzyme, encoded by the GBE1 gene, is responsible for a recently identified recessive fatal fetal and neonatal glycogen storage disease (GSD) in American Quarter Horses termed GSD IV. We have now derived the complete GBE1 cDNA sequences for control horses and affected foals, and identified a C to A substitution at base 102 that results in a tyrosine (Y) to stop (X) mutation in codon 34 of exon 1. All 11 affected foals were homozygous for the X34 allele, their 11 available dams and sires were heterozygous, and all 16 control horses were homozygous for the Y34 allele. The previous findings of poorly branched glycogen, abnormal polysaccharide accumulation, lack of measurable GBE1 enzyme activity and immunodetectable GBE1 protein, coupled with the present observation of abundant GBE1 mRNA in affected foals, are all consistent with the nonsense mutation in the 699 amino acid GBE1 protein. The affected foal pedigrees have a common ancestor and contain prolific stallions that are likely carriers of the recessive X34 allele. Defining the molecular basis of equine GSD IV will allow for accurate DNA testing and the ability to prevent occurrence of this devastating disease affecting American Quarter Horses and related breeds.

The effect of free and carrier-bound cortisol on equine neutrophil function.

PubMed

Fratto, Melanie A; Hart, Kelsey A; Norton, Natalie A; Barton, Michelle H; Giguère, Steeve; Hurley, David J

2017-01-01

Cortisol is a key anti-inflammatory hormone that increases in bacterial sepsis and circulates predominantly bound to cortisol binding globulin (CBG). Only unbound cortisol was believed to be biologically active, but recent evidence suggests that CBG-bound cortisol also regulates inflammation. The objective of this study was to evaluate the effects of free and CBG-bound cortisol on equine neutrophil function ex vivo. We hypothesized that CBG would enhance cortisol-mediated suppression of neutrophil pro-inflammatory responses. Neutrophils isolated from 8 foals and 6 adult horses were exposed to Staphylococcus aureus antigen (SAA) alone and with hydrocortisone (HC), CBG, or both (CBG+HC). Inflammatory cytokine (TNF-α, IL-8) and reactive oxygen species (ROS) production were measured and compared among stimulants and between ages with linear mixed-effects models. CBG and CBG+HC inhibited ROS production induced by SAA in both foal and horse neutrophils, maintaining it at levels comparable to baseline production (P≤0.060-0.907). TNF-α production was not significantly different among stimulants (P=0.284). CBG+HC significantly (P≤0.016) increased IL-8 production by neutrophils in response to SAA in both foals and adults, although the response of foals was significantly greater than that of adults (P<0.001). These findings suggest that CBG directly modulates equine neutrophil responses, but the effects are cytokine- and age-specific. Copyright © 2016 Elsevier B.V. All rights reserved.

Routine castration in 568 draught colts: incidence of evisceration and omental herniation.

PubMed

Shoemaker, R; Bailey, J; Janzen, E; Wilson, D G

2004-05-01

Castration is one of the most common routine surgical procedures performed in the horse, from which a number of potential complications can arise. We undertook a prospective evaluation of short-term complications associated with castration of draught colts over a 3-year period (1998-2000). To compare castration complications in a large number of draught foals with previously published literature. Five hundred and sixty-eight draught colts, age 4 or 5 months, were castrated in field conditions. Foals were observed for complications for 24 h post operatively. There was no significant difference in complication rates between open and closed surgical techniques. Inguinal/scrotal hernia rate was 4.6% (26/568) prior to surgery, and evisceration of the small intestine occurred in 4.8% (27/568). Foals observed to eviscerate underwent immediate surgical correction with an overall survival rate of 72.2% (13/18). Omental herniation was seen in 2.8% (16/568) of colts. This study showed no difference between the closed and open techniques of castration and the rate of omental herniation or evisceration. The evisceration rate in combination with the omental and presurgical herniation rates approached 12.2%, which is high enough to warrant further examination. Future investigation should help to assess predisposing factors for evisceration. Regardless of the technique employed, herniation appears to pose a significant risk to draught foals undergoing castration.

Cortisol and progestin release, heart rate and heart rate variability in the pregnant and postpartum mare, fetus and newborn foal.

PubMed

Nagel, C; Erber, R; Bergmaier, C; Wulf, M; Aurich, J; Möstl, E; Aurich, C

2012-09-01

The mechanisms leading to parturition in the horse in many aspects differ from those in other species. Pregnancy is maintained not by progesterone but by 5α-pregnanes and the progestin precursor pregnenolone originates from the fetus. As parturition approaches, the fetal adrenal switches from pregnenolone to cortisol synthesis but it is not known whether cortisol crosses the placenta. We hypothesized that in parallel to fetal cortisol release, cortisol in the maternal circulation increases before foaling and this increase can be determined in both saliva and plasma. In addition, maternal, fetal and neonatal heart rate and heart rate variability were measured. In 25 pregnant mares, saliva for cortisol analysis was collected 4 times daily from 15 days before to 5 days after foaling. In 13 mares, in addition, fetomaternal electrocardiogram (ECG) recordings were made and blood samples for progestin and cortisol analysis were collected once daily. Heart rate (HR) was recorded until 5 days after foaling. The heart rate variability (HRV) variables standard deviation of the beat-to-beat (RR) interval (SDRR) and root mean square of successive RR differences (RMSSD) were calculated. From Days 15 to 4 before parturition, progestin concentration increased (peak 267 ± 42 ng/mL) and decreased thereafter (P < 0.05, day of foaling 113 ± 18 ng/mL). A prepartum increase in maternal cortisol concentrations was evident in blood (P < 0.05) and saliva (P < 0.05) and paralleled the decrease in progestin concentrations. In mares, HR remained constant during the last days of pregnancy but decreased within one day after parturition (P < 0.05) while maternal HRV did not change. In the fetus and neonate, HR increased from before to after birth (P < 0.05) indicating increasing demands on the cardiovascular system with adaptation to extrauterine life. Copyright © 2012 Elsevier Inc. All rights reserved.

Validation of the ultrasonographic assessment of the femoral trochlea epiphyseal cartilage in foals at osteochondrosis predilected sites with magnetic resonance imaging and histology.

PubMed

Martel, G; Forget, C; Gilbert, G; Richard, H; Moser, T; Olive, J; Laverty, S

2017-11-01

Noninvasive imaging tools are needed to screen foal femoropatellar joints to detect subclinical osteochondrosis lesions due to focal failure of endochondral ossification to enhance early management to optimise intrinsic healing events. Recently investigations employing 3T susceptibility-weighted magnetic resonance imaging (3T SWI MRI) and CT have demonstrated their capacity for early osteochondrosis diagnosis, but these technologies are not practical for field screening. We postulate that ultrasonography is a valuable field tool for the detection of subclinical osteochondrosis lesions. The goals were to 1) describe the ultrasonographic features of the femoral trochlea of healthy and osteochondrosis-predisposed neonatal foals, 2) validate the capacity of ultrasound to assess cartilage canal vascular archictecture and the ossification front and 3) evaluate field feasibility in a pilot study. Experimental study. Ultrasonographic evaluation of osteochondrosis predisposed (n = 10) and control (n = 6) femoral trochleas was performed ex vivo and compared with site-matched histological sections and 3T SWI MRI. The articular and epiphyseal cartilage thickness, ossification front indentation and cartilage canal vascular archictecture were assessed at each ROI. Femoral trochleae of foals (n = 3) aged ≈ 1, 3 and 6 months were also evaluated with ultrasonography in field. Ultrasonographic measurements strongly correlated with the histological measurements. There was no difference in the cartilage thickness or ossification front indentation between control and osteochondrosis-predisposed specimens. The cartilage canal vascular archictecture on ultrasonograms corresponded with the vessel pattern observed on site matched histology and 3T SWI MRI. The number of specimens for study was limited and no early osteochondrosis lesions were present within the predilected group, but a field study is now underway. Ultrasonographic examination of the femoral trochlea permitted accurate evaluation of cartilage thickness, cartilage canal vascular archictecture and ossification front indentation in young foals and is a promising, practical tool for screening subclinical osteochondrosis and monitoring and managing lesions at important clinical sites. © 2017 EVJ Ltd.

Effect of muscle and intensity of finishing diet on meat quality of foals slaughtered at 15 months.

PubMed

Franco, Daniel; Lorenzo, José M

2014-01-01

The effect of muscle and intensity of finishing diet on meat quality of foals slaughtered at 15 months was study. For this work, a total of twenty one foals and six muscles: longissimus dorsi (LD), semimembranosus (SM), semitendinosus (ST), biceps femoris (BF), triceps brachii (TB) and Psoas major & minor (PM) from two different intensities of finishing diet (1.5 vs. 3 kg/day) were analysed. Meat quality (chemical composition, colour characteristics, and textural traits), fatty and amino acid profile and mineral composition were studied. In general the factor muscle had more effect on all traits measured in this study than finishing effect, especially in the fatty acids and mineral composition. SM muscle showed the highest percentage of protein in both finishing groups (22.34 and 21.74% for 3 and 1.5 kg of commercial feeding, respectively). The intramuscular fat content in the analysed muscles ranged between 0.15% (LD in 1.5 group) and 1.83% (PM in 3.0 group). The highest values of iron heme that were obtained in TB muscle (2.46 mg/100 g meat) are a considerable source of bioavailable iron content. The three most abundant fatty acids in both groups and for all muscles studied were oleic acid, palmitoleic acid and linoleic acid. From a healthy point of view, muscles from foals finishing with a minor amount of commercial fodder were the best. The best nutritional value was reached for PM and ST with 14.73% of total omega 3 and the highest polyunsaturated/saturated ratio (1.10), respectively. Concerning amino acid profile, values of essential/non-essential ratio were significantly higher (P<0.001) in muscles of 1.5 diet group foals (0.856) than the other group (0.833). Finally, potassium (243 mg/100 g) and phosphorous (202 mg/100 g) were the two main minerals, followed by sodium (54 mg/100 g) and magnesium (26 mg/100 g). © 2013.

Physicochemical Approach to Determine the Mechanism for Acid-Base Disorders in 793 Hospitalized Foals.

PubMed

Gomez, D E; Biermann, N M; Sanchez, L C

2015-01-01

The quantitative effect of strong electrolytes, unmeasured strong anions (UAs), pCO2, and plasma protein concentrations in determining plasma pH can be demonstrated using the physicochemical approach. Plasma anion gap (AG) and strong ion gap (SIG) are used to assess UAs in different species. Strong ions are a major factor influencing changes in plasma pH of hospitalized foals. AG and SIG accurately predict severe hyper-L-lactatemia ([L-lac(-)] > 7 mmol/L). Seven hundred and ninety three hospitalized foals < 7 days old. Retrospective study. The relationship between measured pH and physicochemical variables, and the relationship between plasma [L-lac(-)] and AG and SIG, were determined using regression analyses. Optimal AG and SIG cut points to predict hyper-L-lactatemia were identified using an ROC curve analysis. Combined, the measured strong ion difference and SIG accounted for 54-69% of the changes in the measured arterial pH of hospitalized foals. AG and SIG were significantly associated with plasma [L-lac(-)] (P < .0001). The receiver operator characteristics (ROC) AUC of AG and SIG for prediction of severe hyper-L-lactatemia were 0.89 (95%CI, 0.8-0.95; P < .0001) and 0.90 (95%CI, 0.81-0.96; P < .0001), respectively. Severe hyper-L-lactatemia was best predicted by AG > 27 mmol/L (sensitivity 80%, 95%CI, 56-94, specificity 85%, 95%CI, 73-93; P < .0001) and SIG <-15 mmol/L (sensitivity 90%, 95%CI, 68-98; specificity 80%; 95%CI, 68-90; P < .0001). Altered concentrations of strong ions (Na(+), K(+), Cl(-)) and UAs were the primary cause of acidemia of hospitalized foals. AG and SIG were good predictors of hyper-L-lactatemia and could be used as surrogate tests. Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Maternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years

PubMed Central

Mendoza, Luis; Peugnet, Pauline; Dubois, Cédric; Dahirel, Michèle; Lejeune, Jean-Philippe; Caudron, Isabelle; Guenon, Isabelle; Camous, Sylvaine; Tarrade, Anne; Wimel, Laurence; Serteyn, Didier; Bouraima-Lelong, Hélène; Chavatte-Palmer, Pascale

2017-01-01

Introduction Pregnant mares and post-weaning foals are often fed concentrates rich in soluble carbohydrates, together with forage. Recent studies suggest that the use of concentrates is linked to alterations of metabolism and the development of osteochondrosis in foals. The aim of this study was to determine if broodmare diet during gestation affects metabolism, osteoarticular status and growth of yearlings overfed from 20 to 24 months of age and/or sexual maturity in prepubertal colts. Material and methods Twenty-four saddlebred mares were fed forage only (n = 12, group F) or cracked barley and forage (n = 12, group B) from mid-gestation until foaling. Colts were gelded at 12 months of age. Between 20 and 24 months of age, all yearlings were overfed (+140% of requirements) using an automatic concentrate feeder. Offspring were monitored for growth between 6 and 24 months of age, glucose homeostasis was evaluated via modified frequently sampled intra veinous glucose tolerance test (FSIGT) at 19 and 24 months of age and osteoarticular status was investigated using radiographic examinations at 24 months of age. The structure and function of testicles from prepubertal colts were analyzed using stereology and RT-qPCR. Results Post-weaning weight growth was not different between groups. Testicular maturation was delayed in F colts compared to B colts at 12 months of age. From 19 months of age, the cannon bone was wider in B vs F yearlings. F yearlings were more insulin resistant at 19 months compared to B yearlings but B yearlings were affected more severely by overnutrition with reduced insulin sensitivity. The osteoarticular status at 24 months of age was not different between groups. Conclusion In conclusion, nutritional management of the pregnant broodmare and the growing foal may affect sexual maturity of colts and the metabolism of foals until 24 months of age. These effects may be deleterious for reproductive and sportive performances in older horses. PMID:28081146

STS-86 crew members Wolf, Chretien and Titov in M-113

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 crew members get a ride in, and learn to operate, an M-113 armored personnel carrier as part of training exercises during the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. George Hoggard, in back at left, a training officer with KSC Fire Services, provides this part of the training to Mission Specialists Wendy B. Lawrence, to the right of Hoggard; Vladimir Georgievich Titov of the Russian Space Agency; and Scott E. Parazynski. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Titov and Parazynski are scheduled to conduct a spacewalk primarily to retrieve four suitcase-sized environmental payloads from the exterior of the Mir docking module. Also during the mission, STS-86 Mission Specialist David A. Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25 from Launch Pad 39A.

Toxicoinfectious botulism in foals and adult horses.

PubMed

Swerczek, T W

1980-02-01

Toxicoinfectious botulism was proved to be the cause of a neuromuscular paralytic syndrome in foals and adult horses. In eight successive cases, Clostridium botulinum type B was isolated at necropsy. Foals were either found dead without premonitory signs of illness or, most often, they had signs of progressive and symmetric motor paralysis. Stilted gait, muscular tremors, and the inability to stand longer than 4 to 5 minutes were the salient clinical signs. Other clinical manifestations included dysphagia, constipation, mydriasis, and frequent urination. As the disease progressed, dyspnea with extension of the head and neck, tachycardia, and respiratory arrest occurred. Death occurred most often 24 to 72 hours after the onset of clinical signs. The most consistent postmortem findings were congestion and edema of the lungs and excessive pericardial fluid, which contained free-floating strands of fibrin. Gastric ulcers, foci of necrosis in the liver, abscesses in the navel and lungs, and wounds of the skin and muscle were predisposing sites for development of toxicoinfectious botulism.

STS-103 crew take part in CEIT

NASA Technical Reports Server (NTRS)

1999-01-01

During a Crew Equipment Interface Test, STS-103 Commander Curtis L. Brown Jr. (left) and Pilot Scott J. Kelly look at a replacement computer for the Hubble Space Telescope. The payload hardware is in the Payload Hazardous Servicing Facility. Other members of the crew are Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-Frangois Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a 'call-up' due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with the new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review.

KSC-99pp1477

NASA Image and Video Library

1999-12-19

KENNEDY SPACE CENTER, FLA. -- As if spawned by the clouds of smoke and steam below, the Space Shuttle Discovery shoots into the night sky on mission STS-103. The brilliant light creates a reflection of the launch in the water nearby. Liftoff occurred at 7:50 p.m. EST from Launch Pad 39B. On board are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. STS-103 is a Hubble Servicing Mission, with three planned space walks designed to install new equipment and replace old. The primary objective is to replace the gyroscopes that make up the three Rate Sensor Units. Extravehicular activities include installing a new computer, changing out one of the Fine Guidance Sensors, replacing a tape recorder with a new solid state recorder, and installing a voltage/temperature improvement kit, and begin repairing the insulation on the telescope's outer surface. After the 7-day, 21-hour mission, Discovery is expected to land at KSC Monday, Dec. 27, at about 5:24 p.m. EST. This is the 27th flight of Discovery and the 96th mission in the Space Shuttle Program. It is the third launch at Kennedy Space Center in 1999

KSC-99pp1331

NASA Image and Video Library

1999-11-16

In the bunker at Launch Pad 39B, STS-103 Mission Specialist Jean-François Clervoy of France, who is with the European Space Agency (ESA), tries on an oxygen mask during Terminal Countdown Demonstration Test (TCDT) activities. The TCDT provides the crew with emergency egress training, opportunities to inspect their mission payloads in the orbiter's payload bay, and simulated countdown exercises. Other crew members taking part are Commander Curtis L. Brown Jr. and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), plus Claude Nicollier of Switzerland, who is also with ESA. STS-103 is a "call-up" mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST

KSC-99pp1092

NASA Image and Video Library

1999-09-02

During a Crew Equipment Interface Test, STS-103 Commander Curtis L. Brown Jr. (left) and Pilot Scott J. Kelly look at a replacement computer for the Hubble Space Telescope. The payload hardware is in the Payload Hazardous Servicing Facility. Other members of the crew are Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a "call-up" due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with the new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review

STS-103 crew take part in CEIT

NASA Technical Reports Server (NTRS)

1999-01-01

In the Payload Hazardous Servicing Facility, the STS-103 crew look over equipment to be used during their mission. The seven-member crew, taking part in a Crew Equipment Interface Test, are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-Frangois Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a 'call-up' due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review.

STS-103 crew take part in CEIT in PHSF

NASA Technical Reports Server (NTRS)

1999-01-01

During a Crew Equipment Interface Test (CEIT), members of the STS-103 crew check out a portable foot restraint on the Flight Support System that will be used on the mission, repairing the Hubble Space Telescope. The seven-member crew comprises Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D), Claude Nicollier of Switzerland, and Jean-Frangois Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a 'call-up' due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review.

STS-103 MS Clervoy tries on oxygen mask

NASA Technical Reports Server (NTRS)

1999-01-01

In the bunker at Launch Pad 39B, STS-103 Mission Specialist Jean-Frangois Clervoy of France, who is with the European Space Agency (ESA), tries on an oxygen mask during Terminal Countdown Demonstration Test (TCDT) activities. The TCDT provides the crew with emergency egress training, opportunities to inspect their mission payloads in the orbiter's payload bay, and simulated countdown exercises. Other crew members taking part are Commander Curtis L. Brown Jr. and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), plus Claude Nicollier of Switzerland, who is also with ESA. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

STS-103 crew take part in CEIT

NASA Technical Reports Server (NTRS)

1999-01-01

In the Payload Hazardous Servicing Facility, members of the STS-103 crew get instructions on use of rib clamps for the Shield Shell Replacement Fabric (SSRF) task on repair of the Hubble Space Telescope. The seven-member crew are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-Frangois Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a 'call-up' due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review.

STS-103 crew take part in CEIT

NASA Technical Reports Server (NTRS)

1999-01-01

In the Payload Hazardous Servicing Facility, members of the STS-103 crew look at some of the equipment to be used during their mission. The seven-member crew are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-Frangois Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a 'call-up' due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review.

KSC-99pp1098

NASA Image and Video Library

1999-09-02

During a Crew Equipment Interface Test (CEIT), members of the STS-103 crew check out a portable foot restraint on the Flight Support System that will be used on the mission, repairing the Hubble Space Telescope. The seven-member crew comprises Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D), Claude Nicollier of Switzerland, and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a "call-up" due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review

KSC-99pp1332

NASA Image and Video Library

1999-11-16

In the bunker at Launch Pad 39B, STS-103 Pilot Scott J. Kelly (left) and Mission Specialist John M. Grunsfeld (Ph.D.) (right) try on oxygen masks during Terminal Countdown Demonstration Test (TCDT) activities. The TCDT provides the crew with emergency egress training, opportunities to inspect their mission payloads in the orbiter's payload bay, and simulated countdown exercises. Other crew members taking part are Commander Curtis L. Brown Jr. and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), and Jean-François Clervoy of France and Claude Nicollier of Switzerland, who are with the European Space Agency. STS-103 is a "call-up" mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST

KSC-99pp1089

NASA Image and Video Library

1999-09-02

In the Payload Hazardous Servicing Facility, members of the STS-103 crew look at some of the equipment to be used during their mission. The seven-member crew are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a "call-up" due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review

KSC-99pp1342

NASA Image and Video Library

1999-11-17

Taking a break during emergency egress training at Launch Pad 39B are (left to right) STS-103 Mission Specialists Jean-François Clervoy of France, Claude Nicollier of Switzerland, Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists John M. Grunsfeld (Ph.D.), C. Michael Foale (Ph.D.) and Steven L. Smith. Clervoy and Nicollier are with the European Space Agency. The training is part of Terminal Countdown Demonstration Test (TCDT) activities that also include opportunities to inspect the mission payloads in the orbiter's payload bay and simulated countdown exercises. STS-103 is a "call-up" mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST

KSC-99pp1086

NASA Image and Video Library

1999-09-02

In the Payload Hazardous Servicing Facility, the STS-103 crew look over equipment to be used during their mission. The seven-member crew, taking part in a Crew Equipment Interface Test, are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a "call-up" due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor and an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review

KSC-99pp1347

NASA Image and Video Library

1999-11-17

STS-103 Mission Commander Curtis L. Brown Jr. sits inside orbiter Discovery waiting for the start of a simulated countdown exercise. The simulation is part of Terminal Countdown Demonstration Test (TCDT) activities. The TCDT also provides the crew with emergency egress training and opportunities to inspect their mission payload in the orbiter's payload bay. Other crew members taking part in the TCDT are Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Jean-François Clervoy of France, and Claude Nicollier of Switzerland. Clervoy and Nicollier are with the European Space Agency. STS-103 is a "call-up" mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST

KSC-99pp1088

NASA Image and Video Library

1999-09-02

In the Payload Hazardous Servicing Facility, members of the STS-103 crew get instructions on use of rib clamps for the Shield Shell Replacement Fabric (SSRF) task on repair of the Hubble Space Telescope. The seven-member crew are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith, C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland, and Jean-François Clervoy of France. Nicollier and Clervoy are with the European Space Agency. Mission STS-103 is a "call-up" due to the need to replace portions of the pointing system, the gyros, which have begun to fail on the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. The gyroscopes allow the telescope to point at stars, galaxies and planets. The STS-103 crew will not only replace gyroscopes, it will also replace a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. The scheduled launch date in October is under review

Assessment of intraocular measurements in neonatal foals and association with gender, laterality, and body weight: a clinical study.

PubMed

Valentini, Simona; Castagnetti, Carolina; Musella, Vincenzo; Spinella, Giuseppe

2014-01-01

Objective of this study was to describe intraocular measurements in newly born foals (1-7 days of age) and assess the association between globe measurements and gender, laterality, and body weight. B-scan ultrasonographic biometry was performed on both eyes of 22 healthy foals (44 eyes) ages 1-7 days using a 10-MHz transducer. Intraocular measurements (anterior chamber depth, central lens thickness, vitreous chamber depth, axial globe length, longitudinal globe length, lens poles distance) were carried out using the ultrasound internal calipers. The influence of gender (male or female), laterality (right or left eye), and body weight ("light" <48 kg; "heavy" ≥48 kg) on ocular measurements was analysed by the Student t test. Values of P<0.05 were accepted as significant for all analyses. Mean anterior chamber depth was 2.2±0.5 mm (Standard Deviation); central lens thickness was 9.9±0.8 mm; vitreous chamber depth was 15.5±1.1 mm; axial globe length was 27.6±1.6 mm; longitudinal globe length was 35.8±1.2 mm, and lens poles distance was 16.4±1.0 mm. Intraocular measurements were not influenced by gender, laterality nor body weight. This study provides reference values for intraocular measurements in neonatal foals and may be useful in the diagnosis and treatment of congenital and acquired pathologies involving the globe.